Carrel name: keyword-patient-cord Creating study carrel named keyword-patient-cord Initializing database file: cache/cord-000001-ug7v899j.json key: cord-000001-ug7v899j authors: Madani, Tariq A; Al-Ghamdi, Aisha A title: Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia date: 2001-07-04 journal: BMC Infect Dis DOI: 10.1186/1471-2334-1-6 sha: doc_id: 1 cord_uid: ug7v899j file: cache/cord-001313-f72hl6du.json key: cord-001313-f72hl6du authors: Toncheva, D.; Mihailova-Hristova, M.; Vazharova, R.; Staneva, R.; Karachanak, S.; Dimitrov, P.; Simeonov, V.; Ivanov, S.; Balabanski, L.; Serbezov, D.; Malinov, M.; Stefanovic, V.; Čukuranović, R.; Polenakovic, M.; Jankovic-Velickovic, L.; Djordjevic, V.; Jevtovic-Stoimenov, T.; Plaseska-Karanfilska, D.; Galabov, A.; Djonov, V.; Dimova, I. title: NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy date: 2014-05-15 journal: Biomed Res Int DOI: 10.1155/2014/920723 sha: doc_id: 1313 cord_uid: f72hl6du file: cache/cord-000831-zwfxnd7r.json key: cord-000831-zwfxnd7r authors: Bakhshayeshkaram, Mehrdad; Saidi, Bahareh; Tabarsi, Payam; Zahirifard, Soheila; Ghofrani, Mishka title: Imaging Findings in Patients With H1N1 Influenza A Infection date: 2011-12-25 journal: Iran J Radiol DOI: 10.5812/iranjradiol.4554 sha: doc_id: 831 cord_uid: zwfxnd7r file: cache/cord-000308-cxr1ul7q.json key: cord-000308-cxr1ul7q authors: Cianchi, Giovanni; Bonizzoli, Manuela; Pasquini, Andrea; Bonacchi, Massimo; Zagli, Giovanni; Ciapetti, Marco; Sani, Guido; Batacchi, Stefano; Biondi, Simona; Bernardo, Pasquale; Lazzeri, Chiara; Giovannini, Valtere; Azzi, Alberta; Abbate, Rosanna; Gensini, Gianfranco; Peris, Adriano title: Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date: 2011-01-11 journal: BMC Pulm Med DOI: 10.1186/1471-2466-11-2 sha: doc_id: 308 cord_uid: cxr1ul7q file: cache/cord-002782-mena480g.json key: cord-002782-mena480g authors: Chen, Jiajia; Wu, Jie; Hao, Shaorui; Yang, Meifang; Lu, Xiaoqing; Chen, Xiaoxiao; Li, Lanjuan title: Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection date: 2017-12-08 journal: Sci Rep DOI: 10.1038/s41598-017-17497-6 sha: doc_id: 2782 cord_uid: mena480g file: cache/cord-000229-9fr0m92p.json key: cord-000229-9fr0m92p authors: Yun, Tae Jin; Kwon, Gu Jin; Oh, Mi Kyeong; Woo, Sung Koo; Park, Seung Hoon; Choi, Seung Hong; Lee, Hyun Ju; Goo, Jin Mo; Yim, Jae-Joon; Kim, Jong Sung; Park, Chang Min title: Radiological and Clinical Characteristics of a Military Outbreak of Pandemic H1N1 2009 Influenza Virus Infection date: 2010-06-21 journal: Korean J Radiol DOI: 10.3348/kjr.2010.11.4.417 sha: doc_id: 229 cord_uid: 9fr0m92p file: cache/cord-002977-o0dvwzxk.json key: cord-002977-o0dvwzxk authors: Gosangi, Babina; Davids, Matthew; Somarouthu, Bhanusupriya; Alessandrino, Francesco; Giardino, Angela; Ramaiya, Nikhil; Krajewski, Katherine title: Review of targeted therapy in chronic lymphocytic leukemia: what a radiologist needs to know about CT interpretation date: 2018-04-18 journal: Cancer Imaging DOI: 10.1186/s40644-018-0146-8 sha: doc_id: 2977 cord_uid: o0dvwzxk file: cache/cord-000716-fhm8abxp.json key: cord-000716-fhm8abxp authors: Wang, Hao; Duan, Qianglin; Wang, Lemin; Gong, Zhu; Liang, Aibin; Wang, Qiang; Song, Haoming; Yang, Fan; Song, Yanli title: Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics date: 2012-07-11 journal: Int J Med Sci DOI: 10.7150/ijms.4641 sha: doc_id: 716 cord_uid: fhm8abxp file: cache/cord-000284-00rk8fb5.json key: cord-000284-00rk8fb5 authors: Hajjar, L. A.; Mauad, T.; Galas, F. R. B. G.; Kumar, A.; da Silva, L. F. F.; Dolhnikoff, M.; Trielli, T.; Almeida, J. P.; Borsato, M. R. L.; Abdalla, E.; Pierrot, L.; Kalil Filho, R.; Auler, J. O. C.; Saldiva, P. H. N.; Hoff, P. M. title: Severe novel influenza A (H1N1) infection in cancer patients date: 2010-05-28 journal: Ann Oncol DOI: 10.1093/annonc/mdq254 sha: doc_id: 284 cord_uid: 00rk8fb5 file: cache/cord-003533-8m0vyxq8.json key: cord-003533-8m0vyxq8 authors: Jayathilaka, P. G. N. S.; Mendis, A. S. V.; Perera, M. H. M. T. S.; Damsiri, H. M. T.; Gunaratne, A. V. C.; Agampodi, Suneth Buddhika title: An outbreak of leptospirosis with predominant cardiac involvement: a case series date: 2019-03-18 journal: BMC Infect Dis DOI: 10.1186/s12879-019-3905-7 sha: doc_id: 3533 cord_uid: 8m0vyxq8 file: cache/cord-002240-38aabxh1.json key: cord-002240-38aabxh1 authors: Prina, Elena; Ceccato, Adrian; Torres, Antoni title: New aspects in the management of pneumonia date: 2016-10-01 journal: Crit Care DOI: 10.1186/s13054-016-1442-y sha: doc_id: 2240 cord_uid: 38aabxh1 file: cache/cord-000522-d498qj2b.json key: cord-000522-d498qj2b authors: Vincent, Jean-Louis; Abraham, Edward; Annane, Djillali; Bernard, Gordon; Rivers, Emanuel; Van den Berghe, Greet title: Reducing mortality in sepsis: new directions date: 2002-12-05 journal: Crit Care DOI: 10.1186/cc1860 sha: doc_id: 522 cord_uid: d498qj2b file: cache/cord-002514-pp06m5xk.json key: cord-002514-pp06m5xk authors: Venkatesan, Sudhir; Myles, Puja R.; Leonardi-Bee, Jo; Muthuri, Stella G.; Al Masri, Malak; Andrews, Nick; Bantar, Carlos; Dubnov-Raz, Gal; Gérardin, Patrick; Koay, Evelyn S. C.; Loh, Tze Ping; Memish, Ziad; Miller, Elizabeth; Oliva, Maria E.; Rath, Barbara A.; Schweiger, Brunhilde; Tang, Julian W.; Tran, Dat; Vidmar, Tjasa; Waight, Pauline A.; Nguyen-Van-Tam, Jonathan S. title: Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis date: 2017-05-15 journal: Clin Infect Dis DOI: 10.1093/cid/cix127 sha: doc_id: 2514 cord_uid: pp06m5xk file: cache/cord-001421-6t5puo6p.json key: cord-001421-6t5puo6p authors: Marfà, Santiago; Crespo, Gonzalo; Reichenbach, Vedrana; Forns, Xavier; Casals, Gregori; Morales-Ruiz, Manuel; Navasa, Miquel; Jiménez, Wladimiro title: Lack of a 5.9 kDa Peptide C-Terminal Fragment of Fibrinogen α Chain Precedes Fibrosis Progression in Patients with Liver Disease date: 2014-10-02 journal: PLoS One DOI: 10.1371/journal.pone.0109254 sha: doc_id: 1421 cord_uid: 6t5puo6p file: cache/cord-002294-qa8e90qv.json key: cord-002294-qa8e90qv authors: Hayakawa, Sho; Matsuzawa, Yasuo; Irie, Tamako; Rikitake, Hagino; Okada, Noriaki; Suzuki, Yasuo title: Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial date: 2016-11-07 journal: Multidiscip Respir Med DOI: 10.1186/s40248-016-0074-z sha: doc_id: 2294 cord_uid: qa8e90qv file: cache/cord-004379-91a7sgir.json key: cord-004379-91a7sgir authors: Han, Nayoung; Oh, Jung Mi; Kim, In-Wha title: Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews date: 2020-02-20 journal: Sci Rep DOI: 10.1038/s41598-020-60068-5 sha: doc_id: 4379 cord_uid: 91a7sgir file: cache/cord-000457-e50a0suk.json key: cord-000457-e50a0suk authors: Rhim, Jung-Woo; Lee, Kyung-Yil; Youn, You-Sook; Kang, Jin-Han; Kim, Ji-Chang title: Epidemiological and clinical characteristics of childhood pandemic 2009 H1N1 virus infection: an observational cohort study date: 2011-08-24 journal: BMC Infect Dis DOI: 10.1186/1471-2334-11-225 sha: doc_id: 457 cord_uid: e50a0suk file: cache/cord-001322-7xmxcm35.json key: cord-001322-7xmxcm35 authors: Walden, Andrew P; Clarke, Geraldine M; McKechnie, Stuart; Hutton, Paula; Gordon, Anthony C; Rello, Jordi; Chiche, Jean-Daniel; Stueber, Frank; Garrard, Christopher S; Hinds, Charles J title: Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort date: 2014-04-01 journal: Crit Care DOI: 10.1186/cc13812 sha: doc_id: 1322 cord_uid: 7xmxcm35 file: cache/cord-004986-en7taikk.json key: cord-004986-en7taikk authors: Nagy, Nathalie; Remmelink, Myriam; van Vooren, J. P.; Salmon, Isabelle title: Infections gastro-intestinales chez le patient immunocompromis date: 2002 journal: Acta Endoscopica DOI: 10.1007/bf03016656 sha: doc_id: 4986 cord_uid: en7taikk file: cache/cord-003828-bhfghcby.json key: cord-003828-bhfghcby authors: Zrzavy, Tobias; Kollaritsch, Herwig; Rommer, Paulus S.; Boxberger, Nina; Loebermann, Micha; Wimmer, Isabella; Winkelmann, Alexander; Zettl, Uwe K. title: Vaccination in Multiple Sclerosis: Friend or Foe? date: 2019-08-07 journal: Front Immunol DOI: 10.3389/fimmu.2019.01883 sha: doc_id: 3828 cord_uid: bhfghcby file: cache/cord-001617-ff3j7i7i.json key: cord-001617-ff3j7i7i authors: Siqueira, André M; Lacerda, Marcus VG; Magalhães, Belisa M L; Mourão, Maria PG; Melo, Gisely C; Alexandre, Márcia AA; Alecrim, Maria GC; Kochar, Dhanpat; Kochar, Sanjay; Kochar, Abhishek; Nayak, Kailash; del Portillo, Hernando; Guinovart, Caterina; Alonso, Pedro; Bassat, Quique title: Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India date: 2015-03-20 journal: BMC Med DOI: 10.1186/s12916-015-0302-y sha: doc_id: 1617 cord_uid: ff3j7i7i file: cache/cord-003404-eqgc8v7y.json key: cord-003404-eqgc8v7y authors: May, Win Lai; Kyaw, Myat Phone; Blacksell, Stuart D.; Pukrittayakamee, Sasithon; Chotivanich, Kesinee; Hanboonkunupakarn, Borimas; Thein, Khin Nyo; Lim, Chae Seung; Thaipadungpanit, Janjira; Althaus, Thomas; Jittamala, Podjanee title: Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children date: 2019-01-02 journal: PLoS One DOI: 10.1371/journal.pone.0209204 sha: doc_id: 3404 cord_uid: eqgc8v7y file: cache/cord-003520-f3jz59pt.json key: cord-003520-f3jz59pt authors: Arabi, Yaseen M.; Tamimi, Waleed; Jones, Gwynne; Jawdat, Dunia; Tamim, Hani; Al-Dorzi, Hasan M.; Sadat, Musharaf; Afesh, Lara; Sakhija, Maram; Al-Dawood, Abdulaziz title: Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date: 2019-02-13 journal: Nutrients DOI: 10.3390/nu11020384 sha: doc_id: 3520 cord_uid: f3jz59pt file: cache/cord-001661-dj9bxhwb.json key: cord-001661-dj9bxhwb authors: Kao, Kuo-Chin; Hu, Han-Chung; Chang, Chih-Hao; Hung, Chen-Yiu; Chiu, Li-Chung; Li, Shih-Hong; Lin, Shih-Wei; Chuang, Li-Pang; Wang, Chih-Wei; Li, Li-Fu; Chen, Ning-Hung; Yang, Cheng-Ta; Huang, Chung-Chi; Tsai, Ying-Huang title: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy date: 2015-05-15 journal: Crit Care DOI: 10.1186/s13054-015-0949-y sha: doc_id: 1661 cord_uid: dj9bxhwb file: cache/cord-003701-i70ztypg.json key: cord-003701-i70ztypg authors: Chow, Eric J.; Doyle, Joshua D.; Uyeki, Timothy M. title: Influenza virus-related critical illness: prevention, diagnosis, treatment date: 2019-06-12 journal: Crit Care DOI: 10.1186/s13054-019-2491-9 sha: doc_id: 3701 cord_uid: i70ztypg file: cache/cord-004310-hl7fa4af.json key: cord-004310-hl7fa4af authors: Matsuishi, Yujiro; Sakuramoto, Hideaki; Hoshino, Haruhiko; Shimojo, Nobutake; Enomoto, Yuki; Mathis, Bryan J.; Hiramatsu, Yuji; Inoue, Yoshiaki title: Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients date: 2020-02-10 journal: Sci Rep DOI: 10.1038/s41598-020-58283-1 sha: doc_id: 4310 cord_uid: hl7fa4af file: cache/cord-002956-e5ihpe4i.json key: cord-002956-e5ihpe4i authors: Chang, Ya-Chun; Huang, Kuo-Tung; Chen, Yu-Mu; Wang, Chin-Chou; Wang, Yi-Hsi; Tseng, Chia-Cheng; Lin, Meng-Chih; Fang, Wen-Feng title: Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure date: 2018-04-04 journal: Sci Rep DOI: 10.1038/s41598-018-24028-4 sha: doc_id: 2956 cord_uid: e5ihpe4i file: cache/cord-004147-9bcq3jnm.json key: cord-004147-9bcq3jnm authors: Fernando, Shannon M.; Mathew, Rebecca; Hibbert, Benjamin; Rochwerg, Bram; Munshi, Laveena; Walkey, Allan J.; Møller, Morten Hylander; Simard, Trevor; Di Santo, Pietro; Ramirez, F. Daniel; Tanuseputro, Peter; Kyeremanteng, Kwadwo title: New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study date: 2020-01-13 journal: Crit Care DOI: 10.1186/s13054-020-2730-0 sha: doc_id: 4147 cord_uid: 9bcq3jnm file: cache/cord-004342-9uok77wb.json key: cord-004342-9uok77wb authors: Lin, Chun-Yu; Lu, Cheng-Hui; Lee, Hsiu-An; See, Lai-Chu; Wu, Meng-Yu; Han, Yi; Tseng, Chi-Nan; Su, I-Li; Li, Han-Yan; Tsai, Feng-Chun title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date: 2020-02-14 journal: Sci Rep DOI: 10.1038/s41598-020-59657-1 sha: doc_id: 4342 cord_uid: 9uok77wb file: cache/cord-001879-bn7h0kcw.json key: cord-001879-bn7h0kcw authors: Papiris, Spyros A; Kagouridis, Konstantinos; Kolilekas, Likurgos; Papaioannou, Andriana I; Roussou, Aneza; Triantafillidou, Christina; Baou, Katerina; Malagari, Katerina; Argentos, Stylianos; Kotanidou, Anastasia; Karakatsani, Anna; Manali, Effrosyni D title: Survival in Idiopathic pulmonary fibrosis acute exacerbations: the non-steroid approach date: 2015-12-14 journal: BMC Pulm Med DOI: 10.1186/s12890-015-0146-4 sha: doc_id: 1879 cord_uid: bn7h0kcw file: cache/cord-004314-gtwtakpr.json key: cord-004314-gtwtakpr authors: Holmen, Heidi; Larsen, Marie Hamilton; Sallinen, Merja Helena; Thoresen, Lisbeth; Ahlsen, Birgitte; Andersen, Marit Helen; Borge, Christine Råheim; Eik, Hedda; Wahl, Astrid Klopstad; Mengshoel, Anne Marit title: Working with patients suffering from chronic diseases can be a balancing act for health care professionals - a meta-synthesis of qualitative studies date: 2020-02-10 journal: BMC Health Serv Res DOI: 10.1186/s12913-019-4826-2 sha: doc_id: 4314 cord_uid: gtwtakpr file: cache/cord-002774-tpqsjjet.json key: cord-002774-tpqsjjet authors: nan title: Section II: Poster Sessions date: 2017-12-01 journal: J Urban Health DOI: 10.1093/jurban/jti137 sha: doc_id: 2774 cord_uid: tpqsjjet file: cache/cord-004404-s6udpwxq.json key: cord-004404-s6udpwxq authors: Seifi, Najmeh; Safarian, Mohammad; Nematy, Mohsen; Rezvani, Reza; Khadem-Rezaian, Majid; Sedaghat, Alireza title: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies date: 2020-02-24 journal: Trials DOI: 10.1186/s13063-020-4136-3 sha: doc_id: 4404 cord_uid: s6udpwxq file: cache/cord-002757-upwe0cpj.json key: cord-002757-upwe0cpj authors: Sullivan, Kathleen E.; Bassiri, Hamid; Bousfiha, Ahmed A.; Costa-Carvalho, Beatriz T.; Freeman, Alexandra F.; Hagin, David; Lau, Yu L.; Lionakis, Michail S.; Moreira, Ileana; Pinto, Jorge A.; de Moraes-Pinto, M. Isabel; Rawat, Amit; Reda, Shereen M.; Reyes, Saul Oswaldo Lugo; Seppänen, Mikko; Tang, Mimi L. K. title: Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies date: 2017-08-07 journal: J Clin Immunol DOI: 10.1007/s10875-017-0426-2 sha: doc_id: 2757 cord_uid: upwe0cpj file: cache/cord-004096-obrq7q57.json key: cord-004096-obrq7q57 authors: Benghanem, Sarah; Mazeraud, Aurélien; Azabou, Eric; Chhor, Vibol; Shinotsuka, Cassia Righy; Claassen, Jan; Rohaut, Benjamin; Sharshar, Tarek title: Brainstem dysfunction in critically ill patients date: 2020-01-06 journal: Crit Care DOI: 10.1186/s13054-019-2718-9 sha: doc_id: 4096 cord_uid: obrq7q57 file: cache/cord-001154-7k59ogn0.json key: cord-001154-7k59ogn0 authors: Memoli, Matthew J.; Athota, Rani; Reed, Susan; Czajkowski, Lindsay; Bristol, Tyler; Proudfoot, Kathleen; Hagey, Rachel; Voell, Jocelyn; Fiorentino, Charles; Ademposi, Angela; Shoham, Shmuel; Taubenberger, Jeffery K. title: The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts date: 2013-11-01 journal: Clinical Infectious Diseases DOI: 10.1093/cid/cit725 sha: doc_id: 1154 cord_uid: 7k59ogn0 file: cache/cord-003291-zuqx6ksy.json key: cord-003291-zuqx6ksy authors: Tang, Pingping; Wang, Jiangshan; Song, Yingna title: Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review date: 2018-11-03 journal: BMC Pregnancy Childbirth DOI: 10.1186/s12884-018-2070-0 sha: doc_id: 3291 cord_uid: zuqx6ksy file: cache/cord-003798-nki2sasr.json key: cord-003798-nki2sasr authors: Vidaur, Loreto; Totorika, Izarne; Montes, Milagrosa; Vicente, Diego; Rello, Jordi; Cilla, Gustavo title: Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis date: 2019-07-24 journal: Ann Intensive Care DOI: 10.1186/s13613-019-0559-y sha: doc_id: 3798 cord_uid: nki2sasr file: cache/cord-000161-hxjxczyr.json key: cord-000161-hxjxczyr authors: Rello, Jordi; Pop-Vicas, Aurora title: Clinical review: Primary influenza viral pneumonia date: 2009-12-21 journal: Crit Care DOI: 10.1186/cc8183 sha: doc_id: 161 cord_uid: hxjxczyr file: cache/cord-001078-5m29nugu.json key: cord-001078-5m29nugu authors: Chen, Xiaorong; Yang, Zongguo; Lu, Yunfei; Xu, Qingnian; Wang, Qiang; Chen, Liang title: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study date: 2013-09-17 journal: PLoS One DOI: 10.1371/journal.pone.0073362 sha: doc_id: 1078 cord_uid: 5m29nugu file: cache/cord-000904-g6ffaer1.json key: cord-000904-g6ffaer1 authors: Ni, Hong; Yang, Mao; Guo, Zhi; Zhang, Ti title: Sorafenib Combined with Cryoablation to Treat Unresectable Hepatocellular Carcinoma date: 2011-09-17 journal: Chin J Cancer Res DOI: 10.1007/s11670-011-0188-y sha: doc_id: 904 cord_uid: g6ffaer1 file: cache/cord-001493-3yu2di1g.json key: cord-001493-3yu2di1g authors: Fujishima, Seitaro title: Pathophysiology and biomarkers of acute respiratory distress syndrome date: 2014-05-07 journal: J Intensive Care DOI: 10.1186/2052-0492-2-32 sha: doc_id: 1493 cord_uid: 3yu2di1g file: cache/cord-000891-5r2in1gw.json key: cord-000891-5r2in1gw authors: Giannella, Maddalena; Rodríguez-Sánchez, Belen; Roa, Paula López; Catalán, Pilar; Muñoz, Patricia; de Viedma, Darío García; Bouza, Emilio title: Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? date: 2012-06-14 journal: Crit Care DOI: 10.1186/cc11387 sha: doc_id: 891 cord_uid: 5r2in1gw file: cache/cord-003219-iryb3v0z.json key: cord-003219-iryb3v0z authors: Kao, Kuo-Chin; Chang, Ko-Wei; Chan, Ming-Cheng; Liang, Shinn-Jye; Chien, Ying-Chun; Hu, Han-Chung; Chiu, Li-Chung; Chen, Wei-Chih; Fang, Wen-Feng; Chen, Yu-Mu; Sheu, Chau-Chyun; Tsai, Ming-Ju; Perng, Wann-Cherng; Peng, Chung-Kan; Wu, Chieh-Liang; Wang, Hao-Chien; Yang, Kuang-Yao title: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning date: 2018-09-24 journal: Ann Intensive Care DOI: 10.1186/s13613-018-0440-4 sha: doc_id: 3219 cord_uid: iryb3v0z file: cache/cord-004636-t6qldq3s.json key: cord-004636-t6qldq3s authors: Saugel, Bernd; Critchley, Lester A. H.; Kaufmann, Thomas; Flick, Moritz; Kouz, Karim; Vistisen, Simon T.; Scheeren, Thomas W. L. title: Journal of Clinical Monitoring and Computing end of year summary 2019: hemodynamic monitoring and management date: 2020-03-14 journal: J Clin Monit Comput DOI: 10.1007/s10877-020-00496-w sha: doc_id: 4636 cord_uid: t6qldq3s file: cache/cord-000268-480d3yfv.json key: cord-000268-480d3yfv authors: Porfyridis, Ilias; Plachouras, Diamantis; Karagianni, Vasiliki; Kotanidou, Anastasia; Papiris, Spyridon A; Giamarellou, Helen; Giamarellos-Bourboulis, Evangelos J title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date: 2010-09-29 journal: BMC Infect Dis DOI: 10.1186/1471-2334-10-286 sha: doc_id: 268 cord_uid: 480d3yfv file: cache/cord-002145-yq7iwp42.json key: cord-002145-yq7iwp42 authors: Ibrahim, Ahmed; Ahmed, Momina M.; Kedir, Seman; Bekele, Delayehu title: Clinical profile and outcome of patients with acute kidney injury requiring dialysis—an experience from a haemodialysis unit in a developing country date: 2016-07-22 journal: BMC Nephrol DOI: 10.1186/s12882-016-0313-8 sha: doc_id: 2145 cord_uid: yq7iwp42 file: cache/cord-004450-daxz9yhp.json key: cord-004450-daxz9yhp authors: Haeberle, Helene; Prohaska, Stefanie; Martus, Peter; Straub, Andreas; Zarbock, Alexander; Marx, Gernot; Zago, Manola; Giera, Martin; Koeppen, Michael; Rosenberger, Peter title: Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study date: 2020-03-04 journal: Trials DOI: 10.1186/s13063-020-4163-0 sha: doc_id: 4450 cord_uid: daxz9yhp file: cache/cord-003686-1pfk4qve.json key: cord-003686-1pfk4qve authors: Kaneko, Naoe; Kurata, Mie; Yamamoto, Toshihiro; Morikawa, Shinnosuke; Masumoto, Junya title: The role of interleukin-1 in general pathology date: 2019-06-06 journal: Inflamm Regen DOI: 10.1186/s41232-019-0101-5 sha: doc_id: 3686 cord_uid: 1pfk4qve file: cache/cord-005482-v5iayczy.json key: cord-005482-v5iayczy authors: nan title: Publication Only date: 2016-03-21 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2016.56 sha: doc_id: 5482 cord_uid: v5iayczy file: cache/cord-001293-dfaxj3bv.json key: cord-001293-dfaxj3bv authors: Cavaillon, Jean-Marc; Eisen, Damon; Annane, Djilalli title: Is boosting the immune system in sepsis appropriate? date: 2014-03-24 journal: Crit Care DOI: 10.1186/cc13787 sha: doc_id: 1293 cord_uid: dfaxj3bv file: cache/cord-003198-1kw5v6rm.json key: cord-003198-1kw5v6rm authors: Vuillard, Constance; Pineton de Chambrun, Marc; de Prost, Nicolas; Guérin, Claude; Schmidt, Matthieu; Dargent, Auguste; Quenot, Jean-Pierre; Préau, Sébastien; Ledoux, Geoffrey; Neuville, Mathilde; Voiriot, Guillaume; Fartoukh, Muriel; Coudroy, Rémi; Dumas, Guillaume; Maury, Eric; Terzi, Nicolas; Tandjaoui-Lambiotte, Yacine; Schneider, Francis; Grall, Maximilien; Guérot, Emmanuel; Larcher, Romaric; Ricome, Sylvie; Le Mao, Raphaël; Colin, Gwenhaël; Guitton, Christophe; Zafrani, Lara; Morawiec, Elise; Dubert, Marie; Pajot, Olivier; Mentec, Hervé; Plantefève, Gaëtan; Contou, Damien title: Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study date: 2018-09-11 journal: Ann Intensive Care DOI: 10.1186/s13613-018-0433-3 sha: doc_id: 3198 cord_uid: 1kw5v6rm file: cache/cord-004532-flo9139j.json key: cord-004532-flo9139j authors: Andrews, Peter; Azoulay, Elie; Antonelli, Massimo; Brochard, Laurent; Brun-Buisson, Christian; Dobb, Geoffrey; Fagon, Jean-Yves; Gerlach, Herwig; Groeneveld, Johan; Mancebo, Jordi; Metnitz, Philipp; Nava, Stefano; Pugin, Jerome; Pinsky, Michael; Radermacher, Peter; Richard, Christian; Tasker, Robert; Vallet, Benoit title: Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis date: 2004-12-18 journal: Intensive Care Med DOI: 10.1007/s00134-004-2529-5 sha: doc_id: 4532 cord_uid: flo9139j file: cache/cord-005496-cnwg4dnn.json key: cord-005496-cnwg4dnn authors: Gutierrez, Guillermo title: Artificial Intelligence in the Intensive Care Unit date: 2020-03-24 journal: Crit Care DOI: 10.1186/s13054-020-2785-y sha: doc_id: 5496 cord_uid: cnwg4dnn file: cache/cord-004646-zhessjqh.json key: cord-004646-zhessjqh authors: Bawazeer, Mohammed; Amer, Marwa; Maghrabi, Khalid; Alshaikh, Kamel; Amin, Rashid; Rizwan, Muhammad; Shaban, Mohammad; De Vol, Edward; Hijazi, Mohammed title: Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial date: 2020-03-20 journal: Trials DOI: 10.1186/s13063-020-4216-4 sha: doc_id: 4646 cord_uid: zhessjqh file: cache/cord-005425-0hxow3sj.json key: cord-005425-0hxow3sj authors: Lekakis, L; Giralt, S; Couriel, D; Shpall, E J; Hosing, C; Khouri, I F; Anderlini, P; Korbling, M; Martin, T; Champlin, R E; de Lima, M title: Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies date: 2006-08-07 journal: Bone Marrow Transplant DOI: 10.1038/sj.bmt.1705467 sha: doc_id: 5425 cord_uid: 0hxow3sj file: cache/cord-003011-vclnb0eh.json key: cord-003011-vclnb0eh authors: de Almeida, Carlos Podalirio Borges; Ziegelmann, Patrícia Klarmann; Couban, Rachel; Wang, Li; Busse, Jason Walter; Silva, Denise Rossato title: Predictors of In-Hospital Mortality among Patients with Pulmonary Tuberculosis: A Systematic Review and Meta-analysis date: 2018-05-08 journal: Sci Rep DOI: 10.1038/s41598-018-25409-5 sha: doc_id: 3011 cord_uid: vclnb0eh file: cache/cord-003446-yp5d29fk.json key: cord-003446-yp5d29fk authors: Edwards, Michael; Ramappa, Arun Jeenahalli title: An Uncommon Cause of Spontaneous Pneumomediastinum and Subcutaneous Emphysema date: 2017-02-03 journal: Eur J Case Rep Intern Med DOI: 10.12890/2017_000549 sha: doc_id: 3446 cord_uid: yp5d29fk file: cache/cord-002853-vj8t28hn.json key: cord-002853-vj8t28hn authors: Joffe, Michael; Wagner, Simon D.; Tang, Julian W. title: Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient date: 2018-01-27 journal: BMC Infect Dis DOI: 10.1186/s12879-018-2962-7 sha: doc_id: 2853 cord_uid: vj8t28hn file: cache/cord-001536-ta1i0ata.json key: cord-001536-ta1i0ata authors: Nair, Girish B; Niederman, Michael S title: Year in review 2013: critical care - respiratory infections date: 2014-10-29 journal: Crit Care DOI: 10.1186/s13054-014-0572-3 sha: doc_id: 1536 cord_uid: ta1i0ata file: cache/cord-000843-e1bn79ui.json key: cord-000843-e1bn79ui authors: nan title: ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme date: 2011-03-01 journal: Insights Imaging DOI: 10.1007/s13244-011-0078-3 sha: doc_id: 843 cord_uid: e1bn79ui file: cache/cord-003376-2qi4aibx.json key: cord-003376-2qi4aibx authors: van de Groep, Kirsten; Nierkens, Stefan; Cremer, Olaf L.; Peelen, Linda M.; Klein Klouwenberg, Peter M. C.; Schultz, Marcus J.; Hack, C. Erik; van der Poll, Tom; Bonten, Marc J. M.; Ong, David S. Y. title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study date: 2018-12-18 journal: Crit Care DOI: 10.1186/s13054-018-2261-0 sha: doc_id: 3376 cord_uid: 2qi4aibx file: cache/cord-002626-jzwwses4.json key: cord-002626-jzwwses4 authors: Kaul, Karen L.; Sabatini, Linda M.; Tsongalis, Gregory J.; Caliendo, Angela M.; Olsen, Randall J.; Ashwood, Edward R.; Bale, Sherri; Benirschke, Robert; Carlow, Dean; Funke, Birgit H.; Grody, Wayne W.; Hayden, Randall T.; Hegde, Madhuri; Lyon, Elaine; Murata, Kazunori; Pessin, Melissa; Press, Richard D.; Thomson, Richard B. title: The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care date: 2017-07-16 journal: Acad Pathol DOI: 10.1177/2374289517708309 sha: doc_id: 2626 cord_uid: jzwwses4 file: cache/cord-003832-q1422ydi.json key: cord-003832-q1422ydi authors: Koyama, Kansuke; Katayama, Shinshu; Tonai, Ken; Shima, Jun; Koinuma, Toshitaka; Nunomiya, Shin title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors date: 2019-08-19 journal: Crit Care DOI: 10.1186/s13054-019-2559-6 sha: doc_id: 3832 cord_uid: q1422ydi file: cache/cord-004186-m817oudw.json key: cord-004186-m817oudw authors: Iwata, Shihoko; Yokokawa, Sumire; Sato, Mihoshi; Ozaki, Makoto title: Anesthetic management of a patient with a continuous-flow left ventricular assist device for video-assisted thoracoscopic surgery: a case report date: 2020-01-20 journal: BMC Anesthesiol DOI: 10.1186/s12871-020-0933-1 sha: doc_id: 4186 cord_uid: m817oudw file: cache/cord-002724-gtv9syzi.json key: cord-002724-gtv9syzi authors: Pfortmueller, Carmen Andrea; Meisel, Christian; Fux, Michaela; Schefold, Joerg C. title: Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers date: 2017-10-23 journal: Intensive Care Med Exp DOI: 10.1186/s40635-017-0163-0 sha: doc_id: 2724 cord_uid: gtv9syzi file: cache/cord-004263-m1ujhhsc.json key: cord-004263-m1ujhhsc authors: Koekkoek, W. A. C.; Menger, Y. A.; van Zanten, F. J. L.; van Dijk, D.; van Zanten, A. R. H. title: The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study date: 2020-02-03 journal: Crit Care DOI: 10.1186/s13054-020-2744-7 sha: doc_id: 4263 cord_uid: m1ujhhsc file: cache/cord-004464-nml9kqiu.json key: cord-004464-nml9kqiu authors: Lhommet, Claire; Garot, Denis; Grammatico-Guillon, Leslie; Jourdannaud, Cassandra; Asfar, Pierre; Faisy, Christophe; Muller, Grégoire; Barker, Kimberly A.; Mercier, Emmanuelle; Robert, Sylvie; Lanotte, Philippe; Goudeau, Alain; Blasco, Helene; Guillon, Antoine title: Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation? date: 2020-03-06 journal: BMC Pulm Med DOI: 10.1186/s12890-020-1089-y sha: doc_id: 4464 cord_uid: nml9kqiu file: cache/cord-003615-vpzzsdld.json key: cord-003615-vpzzsdld authors: Thompson, Kelly B.; Krispinsky, Luke T.; Stark, Ryan J. title: Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies date: 2019-04-24 journal: Mil Med Res DOI: 10.1186/s40779-019-0202-0 sha: doc_id: 3615 cord_uid: vpzzsdld file: cache/cord-004643-uu4uipfy.json key: cord-004643-uu4uipfy authors: Hasan, Mohammad Rubayet; Sundaram, Manu Somasundaram; Sundararaju, Sathyavathi; Tsui, Kin-Ming; Karim, Mohammed Yousuf; Roscoe, Diane; Imam, Omar; Janahi, Mohammad A.; Thomas, Eva; Dobson, Simon; Tan, Rusung; Tang, Patrick; Lopez, Andres Perez title: Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report date: 2020-03-20 journal: BMC Infect Dis DOI: 10.1186/s12879-020-04966-z sha: doc_id: 4643 cord_uid: uu4uipfy file: cache/cord-004339-7nwpic3d.json key: cord-004339-7nwpic3d authors: Rennie, Katherine J.; O’Hara, James; Rousseau, Nikki; Stocken, Deborah; Howel, Denise; Ternent, Laura; Drinnan, Mike; Bray, Alison; Rooshenas, Leila; Hamilton, David W.; Steel, Alison; Fouweather, Tony; Hynes, Ann-Marie; Holstein, Eva-Maria; Oluboyede, Yemi; Abouhajar, Alaa; Wilson, Janet A.; Carrie, Sean title: Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction date: 2020-02-13 journal: Trials DOI: 10.1186/s13063-020-4081-1 sha: doc_id: 4339 cord_uid: 7nwpic3d file: cache/cord-004515-x22q1f21.json key: cord-004515-x22q1f21 authors: Pottecher, Julien; Noll, Eric; Borel, Marie; Audibert, Gérard; Gette, Sébastien; Meyer, Christian; Gaertner, Elisabeth; Legros, Vincent; Carapito, Raphaël; Uring-Lambert, Béatrice; Sauleau, Erik; Land, Walter G.; Bahram, Seiamak; Meyer, Alain; Geny, Bernard; Diemunsch, Pierre title: Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients date: 2020-03-18 journal: Trials DOI: 10.1186/s13063-020-4141-6 sha: doc_id: 4515 cord_uid: x22q1f21 file: cache/cord-005420-60ie0pfd.json key: cord-005420-60ie0pfd authors: Sparrelid, E; Hägglund, H; Remberger, M; Ringdén, O; Lönnqvist, B; Ljungman, P; Andersson, J title: Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection date: 1998-10-09 journal: Bone Marrow Transplant DOI: 10.1038/sj.bmt.1701404 sha: doc_id: 5420 cord_uid: 60ie0pfd file: cache/cord-004949-icsey27p.json key: cord-004949-icsey27p authors: Fernandez-Botran, Rafael; Uriarte, Silvia M.; Arnold, Forest W.; Rodriguez-Hernandez, Lisandra; Rane, Madhavi J.; Peyrani, Paula; Wiemken, Timothy; Kelley, Robert; Uppatla, Srinivas; Cavallazzi, Rodrigo; Blasi, Francesco; Morlacchi, Letizia; Aliberti, Stefano; Jonsson, Colleen; Ramirez, Julio A.; Bordon, Jose title: Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia date: 2014-02-21 journal: Inflammation DOI: 10.1007/s10753-014-9840-2 sha: doc_id: 4949 cord_uid: icsey27p file: cache/cord-005481-00rezmqj.json key: cord-005481-00rezmqj authors: Reid, T; Galanis, E; Abbruzzese, J; Sze, D; Andrews, J; Romel, L; Hatfield, M; Rubin, J; Kirn, D title: Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial date: 2001-11-22 journal: Gene Ther DOI: 10.1038/sj.gt.3301512 sha: doc_id: 5481 cord_uid: 00rezmqj file: cache/cord-005503-hm8tvkt3.json key: cord-005503-hm8tvkt3 authors: Rasulo, Frank A.; Togni, Tommaso; Romagnoli, Stefano title: Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient date: 2020-03-24 journal: Crit Care DOI: 10.1186/s13054-020-2781-2 sha: doc_id: 5503 cord_uid: hm8tvkt3 file: cache/cord-001221-due9tloa.json key: cord-001221-due9tloa authors: nan title: ECR 2014, Part A date: 2014-02-27 journal: Insights Imaging DOI: 10.1007/s13244-014-0316-6 sha: doc_id: 1221 cord_uid: due9tloa file: cache/cord-003532-lcgeingz.json key: cord-003532-lcgeingz authors: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 journal: Crit Care DOI: 10.1186/s13054-019-2358-0 sha: doc_id: 3532 cord_uid: lcgeingz file: cache/cord-005452-ouookpd8.json key: cord-005452-ouookpd8 authors: Ghosh, K; Rafique, B; Tirkey, J; Benjamin, E; Jacob, S; Goes, J title: Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation date: 1999-04-19 journal: Bone Marrow Transplant DOI: 10.1038/sj.bmt.1701647 sha: doc_id: 5452 cord_uid: ouookpd8 file: cache/cord-005606-c8c2rfzi.json key: cord-005606-c8c2rfzi authors: Gordon, Sharon M.; Jackson, James C.; Ely, E. Wesley; Burger, Candace; Hopkins, Ramona O. title: Clinical identification of cognitive impairment in ICU survivors: insights for intensivists date: 2004-10-02 journal: Intensive Care Med DOI: 10.1007/s00134-004-2418-y sha: doc_id: 5606 cord_uid: c8c2rfzi file: cache/cord-005147-mvoq9vln.json key: cord-005147-mvoq9vln authors: nan title: Autorenregister date: 2017-02-23 journal: Med Genet DOI: 10.1007/s11825-017-0126-6 sha: doc_id: 5147 cord_uid: mvoq9vln file: cache/cord-005569-9d51l6bn.json key: cord-005569-9d51l6bn authors: Antonelli, Massimo; Azoulay, Elie; Bonten, Marc; Chastre, Jean; Citerio, Giuseppe; Conti, Giorgio; De Backer, Daniel; Lemaire, François; Gerlach, Herwig; Groeneveld, Johan; Hedenstierna, Goran; Macrae, Duncan; Mancebo, Jordi; Maggiore, Salvatore M.; Mebazaa, Alexandre; Metnitz, Philipp; Pugin, Jerôme; Wernerman, Jan; Zhang, Haibo title: Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia date: 2008-12-09 journal: Intensive Care Med DOI: 10.1007/s00134-008-1371-6 sha: doc_id: 5569 cord_uid: 9d51l6bn file: cache/cord-005587-8iwsvku9.json key: cord-005587-8iwsvku9 authors: Lindén, Viveka; Palmér, Kenneth; Reinhard, Jarl; Westman, Reino; Ehrén, Henrik; Granholm, Tina; Frenckner, Björn title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation date: 2000-10-14 journal: Intensive Care Med DOI: 10.1007/s001340000697 sha: doc_id: 5587 cord_uid: 8iwsvku9 file: cache/cord-005487-vac061r8.json key: cord-005487-vac061r8 authors: nan title: Physicians Abstracts: EBMT 2010 date: 2010-04-07 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2010.40 sha: doc_id: 5487 cord_uid: vac061r8 file: cache/cord-004894-75w35fkd.json key: cord-004894-75w35fkd authors: nan title: Abstract date: 2006-06-14 journal: Eur J Epidemiol DOI: 10.1007/s10654-006-9021-1 sha: doc_id: 4894 cord_uid: 75w35fkd file: cache/cord-005480-yg7salqt.json key: cord-005480-yg7salqt authors: nan title: Oral Sessions and Working Party date: 2008-03-26 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2008.30 sha: doc_id: 5480 cord_uid: yg7salqt file: cache/cord-004675-n8mlxe7p.json key: cord-004675-n8mlxe7p authors: nan title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2019-02-26 journal: J Clin Immunol DOI: 10.1007/s10875-019-00597-5 sha: doc_id: 4675 cord_uid: n8mlxe7p file: cache/cord-005646-xhx9pzhj.json key: cord-005646-xhx9pzhj authors: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 journal: Intensive Care Med DOI: 10.1007/bf02316512 sha: doc_id: 5646 cord_uid: xhx9pzhj file: cache/cord-005697-l1zmrq4p.json key: cord-005697-l1zmrq4p authors: Pène, Frédéric; Pickkers, Peter; Hotchkiss, Richard S. title: Is this critically ill patient immunocompromised? date: 2015-12-02 journal: Intensive Care Med DOI: 10.1007/s00134-015-4161-y sha: doc_id: 5697 cord_uid: l1zmrq4p file: cache/cord-005478-5iu38pr6.json key: cord-005478-5iu38pr6 authors: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date: 2019-07-03 journal: Bone Marrow Transplant DOI: 10.1038/s41409-019-0562-9 sha: doc_id: 5478 cord_uid: 5iu38pr6 file: cache/cord-006179-7uv4yfv2.json key: cord-006179-7uv4yfv2 authors: Cheuk, Daniel Ka Leung; Lee, Tsz Leung; Chiang, Alan Kwok Shing; Ha, Shau Yin; Chan, Godfrey Chi Fung title: Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children date: 2007-09-29 journal: J Neurooncol DOI: 10.1007/s11060-007-9478-0 sha: doc_id: 6179 cord_uid: 7uv4yfv2 file: cache/cord-005105-twsy61oq.json key: cord-005105-twsy61oq authors: nan title: SIU 2015 Abstracts date: 2015-09-21 journal: World J Urol DOI: 10.1007/s00345-015-1684-3 sha: doc_id: 5105 cord_uid: twsy61oq file: cache/cord-005819-fp5khzd5.json key: cord-005819-fp5khzd5 authors: Bonatz, K.; Weiss, A.; Hehlmann, R.; Aßmus, H. -P.; Heine, M. title: Gram-negative bacterial pneumonia with secondary aspergillosis in an AIDS patient date: 1991 journal: Klin Wochenschr DOI: 10.1007/bf01649459 sha: doc_id: 5819 cord_uid: fp5khzd5 file: cache/cord-005705-j765ruj1.json key: cord-005705-j765ruj1 authors: Dreyfuss, Didier title: Is it better to consent to an RCT or to care?: Μηδεν αγαν (“nothing in excess”) date: 2004-12-17 journal: Intensive Care Med DOI: 10.1007/s00134-004-2493-0 sha: doc_id: 5705 cord_uid: j765ruj1 file: cache/cord-006181-fkh2fzbr.json key: cord-006181-fkh2fzbr authors: Bednarczyk, Joseph M.; Kethireddy, Shravan; White, Christopher W.; Freed, Darren H.; Singal, Rohit K.; Bell, Dean; Ahmed, Syed Zaki; Kumar, Anand; Light, Bruce title: Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date: 2015-04-08 journal: Can J Anaesth DOI: 10.1007/s12630-015-0378-z sha: doc_id: 6181 cord_uid: fkh2fzbr file: cache/cord-005692-n4vxazst.json key: cord-005692-n4vxazst authors: Papazian, Laurent; Klompas, Michael; Luyt, Charles-Edouard title: Ventilator-associated pneumonia in adults: a narrative review date: 2020-03-10 journal: Intensive Care Med DOI: 10.1007/s00134-020-05980-0 sha: doc_id: 5692 cord_uid: n4vxazst file: cache/cord-005861-3k8h3euj.json key: cord-005861-3k8h3euj authors: Gravenstein, J. S. title: Safety in anesthesia date: 2014-03-17 journal: Anaesthesist DOI: 10.1007/s00101-002-0319-4 sha: doc_id: 5861 cord_uid: 3k8h3euj file: cache/cord-005992-mu917isy.json key: cord-005992-mu917isy authors: nan title: Abstracts der 49. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date: 2011-10-23 journal: Monatsschr Kinderheilkd DOI: 10.1007/s00112-011-2508-1 sha: doc_id: 5992 cord_uid: mu917isy file: cache/cord-006302-pnnkfid0.json key: cord-006302-pnnkfid0 authors: Ioakeimidou, A.; Pagalou, E.; Kontogiorgi, M.; Antoniadou, E.; Kaziani, K.; Psaroulis, K.; Giamarellos-Bourboulis, E. J.; Prekates, A.; Antonakos, N.; Lassale, P.; Gogos, C. title: Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction date: 2017-04-28 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-017-2988-6 sha: doc_id: 6302 cord_uid: pnnkfid0 file: cache/cord-006544-yr4u61qv.json key: cord-006544-yr4u61qv authors: Miesbach, W.; Scharrer, I.; Asherson, R. A. title: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation date: 2004-03-20 journal: Clin Rheumatol DOI: 10.1007/s10067-004-0864-0 sha: doc_id: 6544 cord_uid: yr4u61qv file: cache/cord-005717-x7gsqlwp.json key: cord-005717-x7gsqlwp authors: Hauser, Gabriel J.; Kaufman, Stuart S.; Matsumoto, Cal S.; Fishbein, Thomas M. title: Pediatric intestinal and multivisceral transplantation: a new challenge for the pediatric intensivist date: 2008-05-24 journal: Intensive Care Med DOI: 10.1007/s00134-008-1141-5 sha: doc_id: 5717 cord_uid: x7gsqlwp file: cache/cord-006518-al94gxjw.json key: cord-006518-al94gxjw authors: Calder, Philip C. title: n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients date: 2004 journal: Lipids DOI: 10.1007/s11745-004-1342-z sha: doc_id: 6518 cord_uid: al94gxjw file: cache/cord-006545-c12m75gq.json key: cord-006545-c12m75gq authors: Pinilla, Inmaculada; Martí de Gracia, Milagros; Quintana-Díaz, Manuel; Figueira, Juan Carlos title: Radiological prognostic factors in patients with pandemic H1N1 (pH1N1) infection requiring hospital admission date: 2011-05-27 journal: Emerg Radiol DOI: 10.1007/s10140-011-0964-5 sha: doc_id: 6545 cord_uid: c12m75gq file: cache/cord-005795-sgi54hq8.json key: cord-005795-sgi54hq8 authors: Ely, E.; Gautam, S.; Margolin, R.; Francis, J.; May, L.; Speroff, T.; Truman, B.; Dittus, R.; Bernard, G.; Inouye, S. title: The impact of delirium in the intensive care unit on hospital length of stay date: 2001-11-08 journal: Intensive Care Med DOI: 10.1007/s00134-001-1132-2 sha: doc_id: 5795 cord_uid: sgi54hq8 file: cache/cord-006841-3u56erru.json key: cord-006841-3u56erru authors: Einsele, Hermann; Bertz, Hartmut; Beyer, Jörg; Kiehl, Michael G.; Runde, Volker; Kolb, Hans-Jochen; Holler, Ernst; Beck, Robert; Schwerdfeger, Rainer; Schumacher, Ulrike; Hebart, Holger; Martin, Hans; Kienast, Joachim; Ullmann, Andrew J.; Maschmeyer, Georg; Krüger, William; Niederwieser, Dietger; Link, Hartmut; Schmidt, Christian A.; Oettle, Helmut; Klingebiel, Thomas title: Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) date: 2003-09-10 journal: Ann Hematol DOI: 10.1007/s00277-003-0772-4 sha: doc_id: 6841 cord_uid: 3u56erru file: cache/cord-006236-2gpwf4z2.json key: cord-006236-2gpwf4z2 authors: nan title: Abstracts from the First International Conference on Heart Failure in Children and Young Adults date: 2004 journal: Pediatr Cardiol DOI: 10.1007/s00246-004-2553-9 sha: doc_id: 6236 cord_uid: 2gpwf4z2 file: cache/cord-006332-ikh45wuy.json key: cord-006332-ikh45wuy authors: Bengmark, Stig; Gianotti, Luca title: Nutritional Support to Prevent and Treat Multiple Organ Failure date: 1996 journal: World J Surg DOI: 10.1007/s002689900075 sha: doc_id: 6332 cord_uid: ikh45wuy file: cache/cord-006679-nhbofufv.json key: cord-006679-nhbofufv authors: Lucarelli, G.; Angelucci, E.; Giardini, C.; Baronciani, D.; Galimberti, M.; Polchi, P.; Erer, B. title: Bone marrow transplantation for thalassemia date: 1993 journal: Indian J Pediatr DOI: 10.1007/bf02751428 sha: doc_id: 6679 cord_uid: nhbofufv file: cache/cord-005750-54hul2lw.json key: cord-005750-54hul2lw authors: Antonelli, Massimo; Azoulay, Elie; Bonten, Marc; Chastre, Jean; Citerio, Giuseppe; Conti, Giorgio; De Backer, Daniel; Lemaire, François; Gerlach, Herwig; Groeneveld, Johan; Hedenstierna, Goran; Macrae, Duncan; Mancebo, Jordi; Maggiore, Salvatore M.; Mebazaa, Alexandre; Metnitz, Philipp; Pugin, Jerôme; Wernerman, Jan; Zhang, Haibo title: Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea date: 2009-02-10 journal: Intensive Care Med DOI: 10.1007/s00134-009-1433-4 sha: doc_id: 5750 cord_uid: 54hul2lw file: cache/cord-005808-w0763esk.json key: cord-005808-w0763esk authors: Moreno, Gerard; Rodríguez, Alejandro; Reyes, Luis F.; Gomez, Josep; Sole-Violan, Jordi; Díaz, Emili; Bodí, María; Trefler, Sandra; Guardiola, Juan; Yébenes, Juan C.; Soriano, Alex; Garnacho-Montero, José; Socias, Lorenzo; del Valle Ortíz, María; Correig, Eudald; Marín-Corral, Judith; Vallverdú-Vidal, Montserrat; Restrepo, Marcos I.; Torres, Antoni; Martín-Loeches, Ignacio title: Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study date: 2018-08-03 journal: Intensive Care Med DOI: 10.1007/s00134-018-5332-4 sha: doc_id: 5808 cord_uid: w0763esk file: cache/cord-006394-ucthbqvt.json key: cord-006394-ucthbqvt authors: Pawlik, Timothy M.; Izzo, Francesco; Cohen, Deborah S.; Morris, Jeffery S.; Curley, Steven A. title: Combined Resection and Radiofrequency Ablation for Advanced Hepatic Malignancies: Results in 172 Patients date: 2003 journal: Ann Surg Oncol DOI: 10.1245/aso.2003.03.026 sha: doc_id: 6394 cord_uid: ucthbqvt file: cache/cord-006523-zxn4oqly.json key: cord-006523-zxn4oqly authors: Lodha, Rakesh; Chandra, Uma; Natchu, Mouli; Nanda, Mrinal; Kabra, S. K. title: Nosocomial infections in pediatric intensive care units date: 2001 journal: Indian J Pediatr DOI: 10.1007/bf02722358 sha: doc_id: 6523 cord_uid: zxn4oqly file: cache/cord-006621-0fxpn7qf.json key: cord-006621-0fxpn7qf authors: Cantwell, Tamara; Ferre, Andrés; Van Sint Jan, Nicolette; Blamey, Rodrigo; Dreyse, Jorge; Baeza, Cristian; Diaz, Rodrigo; Regueira, Tomás title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date: 2017-10-10 journal: J Artif Organs DOI: 10.1007/s10047-017-0998-x sha: doc_id: 6621 cord_uid: 0fxpn7qf file: cache/cord-006750-cg2i2bae.json key: cord-006750-cg2i2bae authors: Stoots, Sarah Abramson; Lief, Lindsay; Erkan, Doruk title: Clinical Insights into Diffuse Alveolar Hemorrhage in Antiphospholipid Syndrome date: 2019-09-06 journal: Curr Rheumatol Rep DOI: 10.1007/s11926-019-0852-7 sha: doc_id: 6750 cord_uid: cg2i2bae file: cache/cord-005497-w81ysjf9.json key: cord-005497-w81ysjf9 authors: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 journal: Crit Care DOI: 10.1186/s13054-020-2772-3 sha: doc_id: 5497 cord_uid: w81ysjf9 file: cache/cord-006343-c0amee70.json key: cord-006343-c0amee70 authors: Martinez Rivera, Andrea; Wales, Paul W. title: Intestinal transplantation in children: current status date: 2016-03-31 journal: Pediatr Surg Int DOI: 10.1007/s00383-016-3885-2 sha: doc_id: 6343 cord_uid: c0amee70 file: cache/cord-005953-5z89yeb6.json key: cord-005953-5z89yeb6 authors: nan title: Abstracts des 114. Internistenkongresses 2008 date: 2008 journal: Med Klin (Munich) DOI: 10.1007/s00063-008-1026-y sha: doc_id: 5953 cord_uid: 5z89yeb6 file: cache/cord-006000-ekwpkzqv.json key: cord-006000-ekwpkzqv authors: Bewig, B.; Stewart, Susan; Böttcher, Heidi; Bastian, Andreas; Tiroke, Andreas; Hirt, Stefan; Haverich, Axel title: Eosinophilic alveolitis in BAL after lung transplantation date: 1999 journal: Transpl Int DOI: 10.1007/s001470050221 sha: doc_id: 6000 cord_uid: ekwpkzqv file: cache/cord-006391-esnsa4u5.json key: cord-006391-esnsa4u5 authors: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 journal: Langenbecks Arch Chir DOI: 10.1007/bf01279099 sha: doc_id: 6391 cord_uid: esnsa4u5 file: cache/cord-006563-qmigctkp.json key: cord-006563-qmigctkp authors: nan title: The abstracts of the 26th congress of ESCTAIC, Timisoara, Romania, September 22–24 2016 date: 2017-03-07 journal: J Clin Monit Comput DOI: 10.1007/s10877-017-9991-4 sha: doc_id: 6563 cord_uid: qmigctkp file: cache/cord-006226-fn7zlutj.json key: cord-006226-fn7zlutj authors: nan title: Abstracts of the 4th annual meeting of the German Society of Clinical Pharmacology and Therapy: Hannover, 14–17 September 1994 date: 1994 journal: Eur J Clin Pharmacol DOI: 10.1007/bf00193489 sha: doc_id: 6226 cord_uid: fn7zlutj file: cache/cord-006344-de4dhv4b.json key: cord-006344-de4dhv4b authors: Seitsonen, E.; Hynninen, M.; Kolho, E.; Kallio-Kokko, H.; Pettilä, V. title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date: 2006-03-21 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-006-0117-z sha: doc_id: 6344 cord_uid: de4dhv4b file: cache/cord-006701-q8qh1kas.json key: cord-006701-q8qh1kas authors: Sadeghi, Behnam; Ersmark, Bo; Moretti, Gianluca; Mattsson, Jonas; Ringdén, Olle title: Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells date: 2019-12-18 journal: Int J Hematol DOI: 10.1007/s12185-019-02804-w sha: doc_id: 6701 cord_uid: q8qh1kas file: cache/cord-006426-baf2d47y.json key: cord-006426-baf2d47y authors: Kimura, Fumio; Shimizu, Hiroaki; Yoshidome, Hiroyuki; Ohtsuka, Masayuki; Miyazaki, Masaru title: Immunosuppression following surgical and traumatic injury date: 2010-08-26 journal: Surg Today DOI: 10.1007/s00595-010-4323-z sha: doc_id: 6426 cord_uid: baf2d47y file: cache/cord-000083-3p81yr4n.json key: cord-000083-3p81yr4n authors: nan title: Poster Exhibition date: 2009-01-31 journal: Hepatol Int DOI: 10.1007/s12072-009-9123-4 sha: doc_id: 83 cord_uid: 3p81yr4n file: cache/cord-005816-i54q5gsu.json key: cord-005816-i54q5gsu authors: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-009-8001-z sha: doc_id: 5816 cord_uid: i54q5gsu file: cache/cord-005777-6rvfsx4p.json key: cord-005777-6rvfsx4p authors: nan title: PS 0420-0716 date: 2007-08-25 journal: Intensive Care Med DOI: 10.1007/s00134-007-0823-8 sha: doc_id: 5777 cord_uid: 6rvfsx4p file: cache/cord-006363-xov4xwpa.json key: cord-006363-xov4xwpa authors: Lu, Gen; Xie, Yaping; Huang, Li; Tong, Zhijie; Xie, Zhiwei; Yu, Jialu; Wu, Peiqiong title: Study of Acute Exogenous Lipoid Pneumonia date: 2016-01-29 journal: Indian J Pediatr DOI: 10.1007/s12098-015-2028-4 sha: doc_id: 6363 cord_uid: xov4xwpa file: cache/cord-006508-rje9bnph.json key: cord-006508-rje9bnph authors: Ballas, Samir K. title: Sickle Cell Anaemia: Progress in Pathogenesis and Treatment date: 2012-10-10 journal: Drugs DOI: 10.2165/00003495-200262080-00003 sha: doc_id: 6508 cord_uid: rje9bnph file: cache/cord-006714-q7wy76e2.json key: cord-006714-q7wy76e2 authors: Delannoy, P.-Y.; Boussekey, N.; Devos, P.; Alfandari, S.; Turbelin, C.; Chiche, A.; Meybeck, A.; Georges, H.; Leroy, O. title: Impact of combination therapy with aminoglycosides on the outcome of ICU-acquired bacteraemias date: 2012-02-15 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-012-1568-z sha: doc_id: 6714 cord_uid: q7wy76e2 file: cache/cord-006856-b1w25ob5.json key: cord-006856-b1w25ob5 authors: nan title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date: 2005 journal: Eur Surg DOI: 10.1007/s10353-005-0216-6 sha: doc_id: 6856 cord_uid: b1w25ob5 file: cache/cord-006464-s8rjoyse.json key: cord-006464-s8rjoyse authors: Bauer, Michael; Kölsch, Uwe; Krüger, Renate; Unterwalder, Nadine; Hameister, Karin; Kaiser, Fabian Marc; Vignoli, Aglaia; Rossi, Rainer; Botella, Maria Pilar; Budisteanu, Magdalena; Rosello, Monica; Orellana, Carmen; Tejada, Maria Isabel; Papuc, Sorina Mihaela; Patat, Oliver; Julia, Sophie; Touraine, Renaud; Gomes, Thusari; Wenner, Kirsten; Xu, Xiu; Afenjar, Alexandra; Toutain, Annick; Philip, Nicole; Jezela-Stanek, Aleksandra; Gortner, Ludwig; Martinez, Francisco; Echenne, Bernard; Wahn, Volker; Meisel, Christian; Wieczorek, Dagmar; El-Chehadeh, Salima; Van Esch, Hilde; von Bernuth, Horst title: Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome date: 2015-02-27 journal: J Clin Immunol DOI: 10.1007/s10875-015-0129-5 sha: doc_id: 6464 cord_uid: s8rjoyse file: cache/cord-006517-845w9r6l.json key: cord-006517-845w9r6l authors: Lalueza, A.; Trujillo, H.; Laureiro, J.; Ayuso, B.; Hernández-Jiménez, P.; Castillo, C.; Torres, M.; Folgueira, D.; Madrid, O.; Díaz-Pedroche, C.; Arrieta, E.; Arévalo, C.; Lumbreras, C. title: Impact of severe hematological abnormalities in the outcome of hospitalized patients with influenza virus infection date: 2017-05-13 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-017-2998-4 sha: doc_id: 6517 cord_uid: 845w9r6l file: cache/cord-007575-5ekgabx5.json key: cord-007575-5ekgabx5 authors: Luby, James P. title: Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses date: 2016-01-14 journal: Am J Med Sci DOI: 10.1097/00000441-198707000-00007 sha: doc_id: 7575 cord_uid: 5ekgabx5 file: cache/cord-006768-r2pa9qw0.json key: cord-006768-r2pa9qw0 authors: Shobha, Vineeta; Fathima, Saba; Prakash, Ravi title: Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India date: 2018-02-28 journal: Clin Exp Med DOI: 10.1007/s10238-018-0492-7 sha: doc_id: 6768 cord_uid: r2pa9qw0 file: cache/cord-007444-c9vu8ako.json key: cord-007444-c9vu8ako authors: Sherk, Peter A.; Grossman, Ronald F. title: The Chronic Obstructive Pulmonary Disease Exacerbation date: 2000-12-01 journal: Clin Chest Med DOI: 10.1016/s0272-5231(05)70179-9 sha: doc_id: 7444 cord_uid: c9vu8ako file: cache/cord-007567-vst954ef.json key: cord-007567-vst954ef authors: Farquharson, Carolyn; Baguley, Karen title: Responding to the severe acute respiratory syndrome (SARS) outbreak: Lessons learned in a Toronto emergency department() date: 2003-06-04 journal: J Emerg Nurs DOI: 10.1067/men.2003.109 sha: doc_id: 7567 cord_uid: vst954ef file: cache/cord-006444-eq56zhtd.json key: cord-006444-eq56zhtd authors: nan title: Abstracts of oral presentations and posters date: 1993 journal: Ann Hematol DOI: 10.1007/bf01695978 sha: doc_id: 6444 cord_uid: eq56zhtd file: cache/cord-006862-5va1yyit.json key: cord-006862-5va1yyit authors: nan title: ITS ASM 2012 date: 2012-11-04 journal: Ir J Med Sci DOI: 10.1007/s11845-012-0856-z sha: doc_id: 6862 cord_uid: 5va1yyit file: cache/cord-006460-3ayc0hne.json key: cord-006460-3ayc0hne authors: Baue, Arthur E. title: Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients date: 2000-10-19 journal: Langenbecks Arch Surg DOI: 10.1007/s004230000162 sha: doc_id: 6460 cord_uid: 3ayc0hne file: cache/cord-006595-brpngt14.json key: cord-006595-brpngt14 authors: Pecchi, A.; De Santis, M.; Torricelli, P.; Romagnoli, R.; Francesco, F. di; Cautero, N.; Pinna, A. title: Radiologic imaging of the transplanted bowel date: 2005-03-04 journal: Abdom Imaging DOI: 10.1007/s00261-004-0288-y sha: doc_id: 6595 cord_uid: brpngt14 file: cache/cord-006864-t5qsjyfi.json key: cord-006864-t5qsjyfi authors: Norris, S.; Collins, C.; Hegarty, J.; O’Farrelly, C.; Carton, J.; Madrigal, L.; O’Donoghue, D. P.; O’Farrelly, C.; Holloway, H.; Fielding, J. F.; Mullins, W.; Hone, S. W.; Donnelly, M.; Powell, F.; Blayney, A. W.; Cahill, E. A.; Daly, S. F.; Turner, M. J.; Sullivan, P. A.; McLoughlin, M.; Skelly, M. M.; Mulcahy, H. E.; Connell, T.; O’Donoghue, D. P.; Duggan, C.; Duffy, M. J.; Troy, A.; Sheahan, K.; Whelan, A.; Herra, C. M.; Keane, C. T.; Johnson, H.; Lee, B.; Doherty, E.; McDonnell, T.; Mulherin, D.; FitzGerald, O.; Bresnihan, B.; Hassett, H. M.; Boyce, A.; Greig, V.; O’Herlihy, C.; Smyth, P. P. A.; Roche, E. F.; McCormack, I.; Tempany, E.; Cullen, M. J.; Smith, D. F.; Smyth, P. P. A.; McBrinn, Y.; Murray, B.; Freaney, R.; Keating, D.; McKenna, M. J.; O’Hare, J. A.; Alam, H.; Raza, Q.; Geoghegan, M.; Killalea, S.; Hall, M.; Feely, J.; Kyne, L.; O’Hara, B.; Cullen, M.; Rea, I. M.; Donnelly, J. P.; Stout, R. W.; Lacey, P.; Donnelly, M. J.; McGrath, J.; Hennessy, T. P.; Timon, C. V. I.; Hyde, D.; Xia, H. X.; Keane, C. T.; Buckley, M.; O’Morain, C.; Buckley, M.; Keating, S.; Xia, H.; Hyde, D.; O’Morain, C.; McGrath, J. P.; Stuart, R. C.; Lawlor, P.; Byrne, P. J.; Walsh, T. N.; Hennessy, T. P. J.; Skelly, M. M.; Mulcahy, H. E.; Connell, T.; O’Donoghue, D. P.; Duggan, C.; Duffy, M.; Troy, A.; Sheahan, K.; Norris, S.; Tubridy, M.; Redmond, J.; Hegarty, J.; Holloway, H.; Fielding, J. F.; Mullins, W.; Monahan, K.; Murphy, R. P.; Headon, D. R.; O’Gorman, T.; O’Reilly, F. M.; Darby, C.; Fielding, J. F.; Murphy, G. M.; Murphy, A.; Codd, M.; Powell, F.; Dervan, P.; Lawlor, D.; Loughlin, S. O.; Flanagan, N.; Watson, R.; Barnes, L.; Flanagan, N.; Watson, R.; Kilgallen, C.; Sweeney, E.; Mynes, A.; Mooney, D.; Donoghue, I.; Browne, O.; Kirrane, J. A.; Murphy, G. M.; McKenna, D.; Young, M.; McKenna, D.; Young, M.; O’Toole, E.; Young, M.; O’Briain, S.; Srinivasan, U.; Feighery, C.; Leonard, N.; Jones, E.; O’Farrelly, C.; Moloney, M. A.; O’Farrelly, C.; Weir, D. G.; Lawler, M.; O’Neill, A.; Gowing, H.; Pamphilon, D.; McCann, S. R.; O’Toole, G.; Orren, A.; Seifer, C. M.; Crowley, D. C.; Sheehan, G. J.; Deignan, T.; Kelly, J.; O’Farrelly, C.; Tormey, V. J.; Faul, J.; Leonard, C.; Burke, C. M.; Poulter, L. W.; Collins, C.; Lynch, S.; Madrigal, L.; Norris, S.; McEntee, G.; Traynor, O.; Hegarty, J.; O’Farrelly, C.; Barry, E.; Collins, C.; Costello, P.; Keavney, A.; O’Donoghue, D. P.; O’Farrelly, C.; Willoughby, R.; Feighery, C.; O’Donnell, C.; Cahill, M.; Earley, A.; Eustace, P.; Osborne, R.; Cahill, M.; Saidlear, C.; Holmes, B.; Early, A.; Eustace, P.; Moran, A. P.; Neisser, A.; Polt, R. J.; Bernheimer, H.; Kainz, M.; Schwerer, B.; Gallagher, L.; Cahill, M.; Saidlear, C.; Early, A.; Firth, R.; Eustace, P.; Kennedy, N.; McGilloway, E.; Redmond, J.; McGilloway, E.; Kennedy, N.; Tubridy, N.; Shields, K.; Cullen, W. K.; Rowan, M. J.; Moore, A. R.; Rowan, M.; Feely, J.; Coakley, D.; Lawlor, B.; Swanwick, G.; Al-Naeemi, R.; Redmond, J.; Murphy, R.; Feely, J.; Codd, N. M.; Goggins, M.; Kennedy, N. P.; Mallon, B. L.; Kennedy, N. P.; Mulherin, D.; FitzGerald, O.; Bresnihan, B.; Mulcahy, H.; Skelly, M.; Donoghue, D. O.; McCarthy, D.; Saunders, A.; Mulherin, D.; Bresnihan, B.; FitzGerald, O.; Veale, D. J.; Belch, J. J. F.; Mulherin, D.; Bresnihan, B.; FitzGerald, O.; Veale, D. J.; Belch, J. J. F.; Mulherin, D.; FitzGerald, O.; Bresnihan, B.; Costello, P.; Breathnach, D.; Murphy, E.; Mulherin, D.; FitzGerald, O.; Bresnihan, B.; Breathnach, D.; Costello, P.; Mulherin, D.; Bresnihan, B.; FitzGerald, O.; Breathnach, D.; Mulherin, D.; Costello, P.; Bresnihan, B.; FitzGerald, O.; Kernohan, G.; Gibson, K.; Wilson, A. G.; Duff, G. W.; de Vries, N.; van de Putte, L. B. A.; Donoghue, J.; O’Kelly, F.; Johnson, Z.; Maher, T.; Kyne, L.; Moran, A.; Keane, C.; O’Neill, D.; Horgan, N.; Barragry, J. M.; O’Neill, D.; O’Herlihy, C.; Campbell, D. M.; Behan, M.; O’Connell, P. R.; Donnelly, V. S.; Crowley, D.; Geary, M.; Boylan, P.; Geary, M.; Fanagan, M.; Boylan, P.; Hickey, K.; Teoh, T.; Doyle, M.; Harrison, R.; Hickey, K.; Lyons, D.; Shenouda, Y.; Coughlan, M.; McKenna, P.; Hickey, K.; Shenouda, Y.; Lyons, D.; McKenna, P.; Coughlan, M.; Lenehan, P.; Foley, M.; Kelehan, P.; Ravichandran, P.; Kelly, M.; Conroy, A.; Fitzpatrick, C.; Egan, D.; Regan, C. L.; McAdam, B. V.; McParland, P.; Boylan, P.; FitzGerald, G. A.; Fitzgerald, D. J.; Sharma, S. C.; Foran, K.; Barry-Kinsella, C.; Harrison, R. F.; Gillespie, F. J.; O’Mahony, P.; Boyle, M.; White, M. J.; Donohoe, F.; Birrane, Y.; Naughton, M.; Tempany, E.; Fitzsimons, R. B.; Piracha, M.; McConkey, S.; Griffin, E.; Hayes, E.; Clarke, T.; Parfrey, N.; Butler, K.; Fitzpatrick, C.; Malone, A. J.; Kearney, P. J.; Duggan, P. F.; Lane, A.; Keville, R.; Turner, M.; Barry, S.; Sloan, D.; Gallagher, S.; Darby, M.; Galligan, P.; Stack, J.; Walsh, N.; O’Sullivan, M.; Fitzgerald, M.; O’Sullivan, M.; Meagher, D.; Sloan, D.; Browne, S.; Meagher, D.; Larkin, C.; Lane, A.; Casey, P.; O’Callaghan, E.; Walsh, N.; Rooney, S.; Walsh, E.; Morris, M.; Lane, A.; Burke, T.; Larkin, C.; O’Callaghan, E.; Browne, S.; Roe, M.; Lane, A.; Larkin, C.; O’Callaghan, E.; Maher, C.; Wrigley, M.; Gill, M.; Burgess, M.; Corcoran, E.; Walsh, D.; Gilmer, B.; Johnson, H.; Hayes, C. B.; Thornton, L.; Fogarty, J.; Lyons, R.; O’Connor, M.; Delaney, V.; Buckley, K.; Johnson, Z.; Johnson, Z.; Lillis, D.; Delany, V.; Hayes, C.; Dack, P.; Igoe, D.; Gilmer, B.; O’Neill, H. J.; Johnson, H.; Igoe, D.; Delaney, V.; Johnson, Z.; Kelly, P.; McKeown, D.; Clancy, L.; Varghese, G.; Hennessy, S.; Codd, M.; Gilmartin, J. J.; Birthistle, K.; Carrington, D.; Maguire, H.; Atkinson, P.; Foley-Nolan, C.; Lynch, M.; Cryan, B.; Whyte, D.; Cryan, B.; Conlon, C.; Foley-Nolan, C.; Johnson, Z.; Hayes, C.; Delany, V.; Kucinskas, V.; Usinskiene, U.; Sakalyte, I.; Johnson, Z.; Hayes, C.; Delaney, V.; Dack, P.; Gill, M.; Dawson, E.; Molloy, K.; Goulden, N.; Lawler, M.; McCann, S. R.; Doyle, J.; Lawlor, E.; Lawler, M.; Harrington, M. G.; El-Nageh, N.; Nolan, M. -L.; El-Nageh, N.; Nolan, M. -L.; Harrington, M. G.; Lawlor, E.; O’Riordan, J.; McCann, S. R.; Judge, G.; Crotty, G.; Finch, T.; Borton, M.; Barnes, T.; Gilligan, O.; Lee, G.; Limmer, R.; Madden, M.; Whyte, D.; Cryan, B.; Bergin, C.; O’Leary, A.; Keating, S.; Mulcahy, F.; Wallis, F.; Glennon, M.; Cormican, M.; NiRiain, U.; Heiginbothom, M.; Gannon, F.; Smith, T.; O’Sullivan, C.; Hone, R.; Orren, A.; Caugant, D. A.; Fijen, C. A. P.; Van Schalkwyk, E. J.; Coetzee, G. J.; Lynch, M.; Cryan, B.; Riain, U. Ni; Cormican, M. G.; Park, L.; Flynn, J.; Glennon, M.; O’Connor, M.; Regazzoli, V.; O’Connor, M.; Hayes, M.; Nicholson, G.; Higgins, P.; NiRiain, U.; Flynn, N.; Corbett-Feeney, G.; Conway, D. J.; Sheahan, K.; O’Higgins, N. J.; Smyth, P. P. A.; Rajendiran, S.; Byrne, J.; Kilfeather, E.; Dingle, P.; Hunter, M.; Kelehan, P.; Al-Ghazal, S. K.; Stanley, P.; Palmer, J.; Hong, A.; Al-Ghazal, S. K.; Saxby, P.; Al-Ghazal, S. K.; Saxby, P.; McConkey, S.; Sheehan, D.; Regan, I.; O’Mullane, J.; Chaoimh, M. Ni; Leahy, M.; Heffron, J. J.; Lehane, M.; Keohane, C.; O’Leary, N.; Sheehan, M.; Renny-Walsh, E.; Whelton, M. J.; Doyle, C. T.; Webster, J.; Benjamin, N.; Lyons, D.; FitzGerald, S.; Chadha, J. S.; FitzGerald, M. G.; FitzGerald, G. R.; Hemeryck, L.; McGettigan, P.; Feely, J.; McGettigan, P.; Feely, J.; McGettigan, P.; Golden, J.; Feely, J.; Arthur, N.; Wen, S. Y.; Killalea, S.; Deegan, P.; McGettigan, P.; Feely, J.; Cooke, T.; Adebayo, G. I.; Feely, J.; Gaffney, P.; Sinnot, M.; O’Riordan, D.; Hayes, T.; O’Connor, C. M.; FitzGerald, M. X.; Costello, C.; Finlay, G.; Hayes, J.; O’Connor, C.; FitzGerald, M. X.; McMahon, K.; O’Farrelly, C.; O’Connor, C.; FitzGerald, M. X.; Donnelly, M. J.; Hone, S.; Robertson, J.; Coakley, R.; O’Neill, S.; Walsh, M.; McCarthy, J.; Lannon, D.; Wood, A. E.; Sharkey, R.; Mulloy, E.; Long, M.; Kilgallen, I.; O’Neill, S.; Faul, J.; Tormey, V.; Leonard, C.; Burke, C. M.; Poulter, L. W.; Horne, S.; Tormey, V. J.; Faul, J.; Leonard, C.; Burke, C. M.; Feeney, T.; Muiré, Ó. Ó; Gilmartin, J. J.; Griffin, M. J.; Hughes, D.; Knaggs, A.; Magee, D.; Donnelly, M.; McCrory, C.; March, B.; Hone, R.; Phelan, D.; White, M.; Fabry, J.; Lynch, M.; Buggy, D.; Cooney, C.; Hughes, D.; McCrory, C.; Aziz, E.; O’Herlihy, C.; Kelly, J.; O’Keefe, D.; McShane, A. J.; Boylan, J.; Tobin, E.; Smith, T.; Motherway, C.; Colreavy, F.; Denish, N.; Dwyer, R.; Bergin, A.; O’Brien, K.; MacSullivan, R.; Carson, K. D.; Blunnie, W. P.; Moriarty, D. C.; Carson, K. D.; Blunnie, W. P.; Moriarty, D. C.; Kinirons, B.; Lyons, B.; Cregg, N.; Casey, W.; Moore, K. P.; Colbert, S. A.; Ecoffey, C.; O’Gorman, D.; Fitzgerald, J.; Phelan, D.; Diamond, P.; Codd, M. B.; Sugrue, D. D.; Kellett, J.; Tighe, M.; McKenna, C. J.; Galvin, J.; McCann, H. A.; Sugrue, D. D.; McKenna, C. J.; Codd, M. B.; McCann, H. A.; Sugrue, D. D.; Scallon, A.; Buckley, M.; Fraser, A.; Norton, M.; Tomkin, G.; Graham, I.; Byrne, A.; Maher, M.; Moran, N.; Fitzgerald, D.; O’Callaghan, D.; Coyle, D.; Nugent, A. G.; McGurk, C.; Johnston, G. D.; McGurk, C.; Nugent, A.; Silke, B.; Nugent, A. G.; Johnston, G. D.; Murphy, N.; Jennings, L.; Pratico, D.; Doyle, C.; Fitzgerald, D.; Hennessy, T.; McCann, H.; Sugrue, D.; Hennessy, T.; Codd, M.; Donnelly, S.; Hennessy, A.; Hartigan, C.; McCann, H.; Sugrue, D.; Hennessy, T.; Codd, M.; Donnelly, S.; Hennessy, A.; Hartigan, C.; McCann, H.; Sugrue, D.; Hennessy, T.; MacDonald, D.; Blake, S.; McCann, H.; Sugrue, D.; Hennessy, T.; Sugrue, D.; McCann, H.; Hennessy, T.; McCann, H.; Sugrue, D.; Hennessy, T.; McDonald, D.; Blake, S.; Dominque, D.; Sugrue, D.; McMechan, S. R.; MacKenzie, G.; Allen, J.; Wright, G. T.; Dempsey, G. J.; Crawley, M.; Anderson, J.; Adgey, A. A. J.; Harbinson, M. T.; Campbell, N. P. S.; Wilson, C. M.; Ellis, P. K.; McIlrath, E. M.; Freaney, R.; McShane, A.; Keaveny, T. V.; McKenna, M. J.; Rabenstein, K.; Scheller, F.; Pfeiffer, D.; Urban, C.; Moser, I.; Jobst, G.; Manz, A.; Verpoorte, S.; Dempsey, F.; Diamond, D.; Smyth, M.; Rabenstein, K.; Dempsey, E.; McShane, A.; Keaveny, T. V.; McKenna, M. J.; Freaney, R.; Hamilton, V.; Dwyer, R.; Twomey, J.; Crowley, R.; Fenelon, L.; Walsh, F.; McCann, J.; McDonagh, P.; White, M.; McGovern, E.; Luke, D.; Phelan, D.; McCrory, C.; Crowley, K.; Lyons, B.; Mannion, D.; Wood, A. E.; Casey, W.; Murphy, D.; Clarkson, K.; Carton, E.; Higgins, P.; Leonard, I.; O’Toole, D.; Staunton, M.; Phelan, D.; Srinivasan, U.; Leonard, N.; Jones, E.; Moloney, M. A.; Weir, D. G.; O’Farrelly, C.; Feighery, C.; Griffin, M.; Owens, D.; Collins, P.; Johnson, A.; Tomkin, G. H.; Herity, N. A.; Allen, J. D.; Silke, B.; Adgey, A. A. J.; O’Reilly, F. M.; Darby, C.; O’Moore, R.; Fielding, J. F.; Murphy, G. M.; Crotty, G. M.; Judge, G.; McCann, S. R.; DeArce, M.; Nugent, A. G.; McGurk, C.; Johnston, G. D.; Nikookam, K.; Keenan, P.; Cregan, D.; Firth, R.; O’Meara, N.; Forman, S.; Cusack, D. A.; Farrell, B. title: National scientific medical meeting 1995 abstracts: Oral presentations date: 1995 journal: Ir J Med Sci DOI: 10.1007/bf02967283 sha: doc_id: 6864 cord_uid: t5qsjyfi file: cache/cord-006869-g2q1gpp0.json key: cord-006869-g2q1gpp0 authors: nan title: Neurocritical Care Society 7th Annual Meeting date: 2009-10-08 journal: Neurocrit Care DOI: 10.1007/s12028-009-9282-0 sha: doc_id: 6869 cord_uid: g2q1gpp0 file: cache/cord-007009-4wbvdg1r.json key: cord-007009-4wbvdg1r authors: Takahashi, Toru; Maeda, Ken; Suzuki, Tadaki; Ishido, Aki; Shigeoka, Toru; Tominaga, Takayuki; Kamei, Toshiaki; Honda, Masahiro; Ninomiya, Daisuke; Sakai, Takenori; Senba, Takanori; Kaneyuki, Shozo; Sakaguchi, Shota; Satoh, Akira; Hosokawa, Takanori; Kawabe, Yojiro; Kurihara, Shintaro; Izumikawa, Koichi; Kohno, Shigeru; Azuma, Taichi; Suemori, Koichiro; Yasukawa, Masaki; Mizutani, Tetsuya; Omatsu, Tsutomu; Katayama, Yukie; Miyahara, Masaharu; Ijuin, Masahito; Doi, Kazuko; Okuda, Masaru; Umeki, Kazunori; Saito, Tomoya; Fukushima, Kazuko; Nakajima, Kensuke; Yoshikawa, Tomoki; Tani, Hideki; Fukushi, Shuetsu; Fukuma, Aiko; Ogata, Momoko; Shimojima, Masayuki; Nakajima, Noriko; Nagata, Noriyo; Katano, Harutaka; Fukumoto, Hitomi; Sato, Yuko; Hasegawa, Hideki; Yamagishi, Takuya; Oishi, Kazunori; Kurane, Ichiro; Morikawa, Shigeru; Saijo, Masayuki title: The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan date: 2014-03-15 journal: J Infect Dis DOI: 10.1093/infdis/jit603 sha: doc_id: 7009 cord_uid: 4wbvdg1r file: cache/cord-007321-7gi6xrci.json key: cord-007321-7gi6xrci authors: Chow, Anthony W.; Hall, Caroline B.; Klein, Jerome O.; Kammer, Robert B.; Meyer, Richard D.; Remington, Jack S. title: Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections date: 1992-11-17 journal: Clin Infect Dis DOI: 10.1093/clind/15.supplement_1.s62 sha: doc_id: 7321 cord_uid: 7gi6xrci file: cache/cord-006828-i88on326.json key: cord-006828-i88on326 authors: nan title: Abstracts DGRh-Kongress 2013 date: 2013-09-15 journal: Z Rheumatol DOI: 10.1007/s00393-013-1255-1 sha: doc_id: 6828 cord_uid: i88on326 file: cache/cord-007564-ljqrxjvv.json key: cord-007564-ljqrxjvv authors: Leroy, O. title: 04 – Apport des explorations microbiologiques au diagnostic des infections des voies respiratoires basses date: 2006-11-13 journal: Med Mal Infect DOI: 10.1016/j.medmal.2006.07.008 sha: doc_id: 7564 cord_uid: ljqrxjvv file: cache/cord-006702-ekf6mja9.json key: cord-006702-ekf6mja9 authors: nan title: Abstracts for the 17th IPNA Congress, Iguaçu, Brazil, September 2016: Oral Presentations date: 2016-08-17 journal: Pediatr Nephrol DOI: 10.1007/s00467-016-3466-6 sha: doc_id: 6702 cord_uid: ekf6mja9 file: cache/cord-000718-7whai7nr.json key: cord-000718-7whai7nr authors: nan title: ESP Abstracts 2012 date: 2012-08-22 journal: Virchows Arch DOI: 10.1007/s00428-012-1284-1 sha: doc_id: 718 cord_uid: 7whai7nr file: cache/cord-005881-oswgjaxz.json key: cord-005881-oswgjaxz authors: nan title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-010-8888-z sha: doc_id: 5881 cord_uid: oswgjaxz file: cache/cord-007563-33jxxp1b.json key: cord-007563-33jxxp1b authors: nan title: Full Issue PDF date: 2018-06-25 journal: JACC Basic Transl Sci DOI: 10.1016/s2452-302x(18)30124-4 sha: doc_id: 7563 cord_uid: 33jxxp1b file: cache/cord-006882-t9w1cdr4.json key: cord-006882-t9w1cdr4 authors: nan title: Royal Academy of Medicine in Ireland date: 2012-07-22 journal: Ir J Med Sci DOI: 10.1007/s11845-012-0833-6 sha: doc_id: 6882 cord_uid: t9w1cdr4 file: cache/cord-006975-u5ecibta.json key: cord-006975-u5ecibta authors: Haviland, Kelly; Tan, Kay See; Schwenk, Nadja; Pillai, Manju V.; Stover, Diane E.; Downey, Robert J. title: Outcomes after long-term mechanical ventilation of cancer patients date: 2020-03-30 journal: BMC Palliat Care DOI: 10.1186/s12904-020-00544-x sha: doc_id: 6975 cord_uid: u5ecibta file: cache/cord-006924-1i3kf01j.json key: cord-006924-1i3kf01j authors: nan title: Abstracts from USCAP 2020: Pulmonary, Mediastinum, Pleura, and Peritoneum Pathology (1869-1980) date: 2020-03-05 journal: Lab Invest DOI: 10.1038/s41374-020-0400-0 sha: doc_id: 6924 cord_uid: 1i3kf01j file: cache/cord-007818-jfp9uumb.json key: cord-007818-jfp9uumb authors: Papali, Alfred; Adhikari, Neill K. J.; Diaz, Janet V.; Dondorp, Arjen M.; Dünser, Martin W.; Jacob, Shevin T.; Phua, Jason; Romain, Marc; Schultz, Marcus J. title: Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings date: 2019-02-09 journal: Sepsis Management in Resource-limited Settings DOI: 10.1007/978-3-030-03143-5_3 sha: doc_id: 7818 cord_uid: jfp9uumb file: cache/cord-006888-qfnukav4.json key: cord-006888-qfnukav4 authors: nan title: Irish Thoracic Society Annual Scientific Meeting, Ramada Hotel, Belfast: 7th–8th November 2008 date: 2008-10-21 journal: Ir J Med Sci DOI: 10.1007/s11845-008-0235-y sha: doc_id: 6888 cord_uid: qfnukav4 file: cache/cord-007786-cu831tl7.json key: cord-007786-cu831tl7 authors: Dondorp, Arjen M.; Hoang, Mai Nguyen Thi; Mer, Mervyn; Dünser, Martin W.; Mohanty, Sanjib; Nakibuuka, Jane; Schultz, Marcus J.; Thwaites, C. Louise; Wills, Bridget title: Management of Severe Malaria and Severe Dengue in Resource-Limited Settings date: 2019-02-09 journal: Sepsis Management in Resource-limited Settings DOI: 10.1007/978-3-030-03143-5_9 sha: doc_id: 7786 cord_uid: cu831tl7 file: cache/cord-007833-wkv808ix.json key: cord-007833-wkv808ix authors: Modi, Dipenkumar; Mamdani, Hirva; Vettese, Theresa title: Pomalidomide-Induced Pulmonary Toxicity in Multiple Myeloma date: 2015-12-16 journal: Am J Med Sci DOI: 10.1097/maj.0000000000000532 sha: doc_id: 7833 cord_uid: wkv808ix file: cache/cord-008672-luoxomif.json key: cord-008672-luoxomif authors: Mwachari, C.; Batchelor, B.I.F.; Paul, J.; Waiyaki, P.G.; Gilks, C.F. title: Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya date: 2004-10-29 journal: J Infect DOI: 10.1016/s0163-4453(98)90561-8 sha: doc_id: 8672 cord_uid: luoxomif file: cache/cord-007580-qwh8ei60.json key: cord-007580-qwh8ei60 authors: Knopf, Harry L.S.; Hierholzer, John C. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 journal: Am J Ophthalmol DOI: 10.1016/0002-9394(75)90398-0 sha: doc_id: 7580 cord_uid: qwh8ei60 file: cache/cord-000977-ka4261wc.json key: cord-000977-ka4261wc authors: nan title: ECR 2013 Book of Abstracts - B - Scientific Sessions date: 2013-03-07 journal: Insights Imaging DOI: 10.1007/s13244-013-0228-x sha: doc_id: 977 cord_uid: ka4261wc file: cache/cord-007696-83v9yfa6.json key: cord-007696-83v9yfa6 authors: Zisman, David A.; Keane, Michael P.; Belperio, John A.; Strieter, Robert M.; Lynch, Joseph P. title: Pulmonary Fibrosis date: 2005 journal: Fibrosis Research DOI: 10.1385/1-59259-940-0:003 sha: doc_id: 7696 cord_uid: 83v9yfa6 file: cache/cord-007788-09t52zix.json key: cord-007788-09t52zix authors: Wallhult, Elisabeth; Quinn, Barry title: Early and Acute Complications and the Principles of HSCT Nursing Care date: 2017-11-22 journal: The European Blood and Marrow Transplantation Textbook for Nurses DOI: 10.1007/978-3-319-50026-3_9 sha: doc_id: 7788 cord_uid: 09t52zix file: cache/cord-006876-v2m5l5wz.json key: cord-006876-v2m5l5wz authors: nan title: Neurocritical Care Society 14(th) Annual Meeting date: 2016-08-11 journal: Neurocrit Care DOI: 10.1007/s12028-016-0301-7 sha: doc_id: 6876 cord_uid: v2m5l5wz file: cache/cord-007798-9ht7cqhu.json key: cord-007798-9ht7cqhu authors: Smith, Silas W. title: Drugs and pharmaceuticals: management of intoxication and antidotes date: 2010-02-25 journal: Molecular, Clinical and Environmental Toxicology DOI: 10.1007/978-3-7643-8338-1_12 sha: doc_id: 7798 cord_uid: 9ht7cqhu file: cache/cord-007865-1oyl6clq.json key: cord-007865-1oyl6clq authors: Walsh, Paul; Cortez, Valarie; Bhakta, Himanshu title: Patients Would Prefer Ward to Emergency Department Boarding While Awaiting an Inpatient Bed date: 2008-02-21 journal: J Emerg Med DOI: 10.1016/j.jemermed.2007.05.012 sha: doc_id: 7865 cord_uid: 1oyl6clq file: cache/cord-006880-9dgmdtj8.json key: cord-006880-9dgmdtj8 authors: nan title: Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date: 2012-09-19 journal: Neurocrit Care DOI: 10.1007/s12028-012-9775-0 sha: doc_id: 6880 cord_uid: 9dgmdtj8 file: cache/cord-006182-kck5e1ry.json key: cord-006182-kck5e1ry authors: nan title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date: 2019-10-01 journal: Neurocrit Care DOI: 10.1007/s12028-019-00857-7 sha: doc_id: 6182 cord_uid: kck5e1ry file: cache/cord-005727-li8pwigg.json key: cord-005727-li8pwigg authors: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-1999-x sha: doc_id: 5727 cord_uid: li8pwigg file: cache/cord-008596-zhk82cor.json key: cord-008596-zhk82cor authors: Watts, Clark title: Erosion of physician autonomy and public respect for the profession() date: 2008-07-09 journal: Surg Neurol DOI: 10.1016/j.surneu.2008.05.005 sha: doc_id: 8596 cord_uid: zhk82cor file: cache/cord-009285-1ddfywfa.json key: cord-009285-1ddfywfa authors: Assicot, M.; Bohuon, C.; Gendrel, D.; Raymond, J.; Carsin, H.; Guilbaud, J. title: High serum procalcitonin concentrations in patients with sepsis and infection date: 1993-02-27 journal: Lancet DOI: 10.1016/0140-6736(93)90277-n sha: doc_id: 9285 cord_uid: 1ddfywfa file: cache/cord-009417-458rrhcm.json key: cord-009417-458rrhcm authors: Luce, Judith A. title: Use of Blood Components in the Intensive Care Unit date: 2009-05-15 journal: Critical Care Medicine DOI: 10.1016/b978-032304841-5.50082-0 sha: doc_id: 9417 cord_uid: 458rrhcm file: cache/cord-009278-98ebmd33.json key: cord-009278-98ebmd33 authors: Ferreira-Coimbra, João; Sarda, Cristina; Rello, Jordi title: Burden of Community-Acquired Pneumonia and Unmet Clinical Needs date: 2020-02-18 journal: Adv Ther DOI: 10.1007/s12325-020-01248-7 sha: doc_id: 9278 cord_uid: 98ebmd33 file: cache/cord-008695-y7il3hyb.json key: cord-008695-y7il3hyb authors: nan title: Pandemic Flu: Clinical management of patients with an influenza-like illness during an influenza pandemic date: 2007-01-25 journal: J Infect DOI: 10.1016/s0163-4453(07)60001-2 sha: doc_id: 8695 cord_uid: y7il3hyb file: cache/cord-009360-rgwe2pkx.json key: cord-009360-rgwe2pkx authors: Pilatz, Adrian; Kilb, Jill; Kaplan, Huelya; Fietz, Daniela; Hossain, Hamid; Schüttler, Christian G.; Diemer, Thorsten; Bergmann, Martin; Domann, Eugen; Weidner, Wolfgang; Wagenlehner, Florian; Schuppe, Hans-Christian title: High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval date: 2019-08-27 journal: Andrologia DOI: 10.1111/and.13401 sha: doc_id: 9360 cord_uid: rgwe2pkx file: cache/cord-009891-gqrhbhbn.json key: cord-009891-gqrhbhbn authors: Rassool, G. Hussein title: Current issues and forthcoming events date: 2003-09-03 journal: J Adv Nurs DOI: 10.1046/j.1365-2648.2003.02701.x-i2 sha: doc_id: 9891 cord_uid: gqrhbhbn file: cache/cord-009512-o4y9s8zf.json key: cord-009512-o4y9s8zf authors: Huang, Jiajia; Lin, Tongyu; Li, Zhi‐Ming; Xu, Ruihua; Huang, Huiqiang; Jiang, Wenqi title: Primary pulmonary non‐Hodgkin's lymphoma: A retrospective analysis of 29 cases in a Chinese population date: 2010-03-24 journal: Am J Hematol DOI: 10.1002/ajh.21720 sha: doc_id: 9512 cord_uid: o4y9s8zf file: cache/cord-010116-hfzs16jh.json key: cord-010116-hfzs16jh authors: Díaz‐Ravetllat, V.; Greer, M.; Haverich, A.; Warnecke, G.; Dierich, M.; Welte, T.; Gottlieb, J. title: Significance of new lung infiltrates in outpatients after lung and heart–lung transplantation date: 2014-04-12 journal: Transpl Infect Dis DOI: 10.1111/tid.12209 sha: doc_id: 10116 cord_uid: hfzs16jh file: cache/cord-006860-a3b8hyyr.json key: cord-006860-a3b8hyyr authors: nan title: 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date: 1996 journal: Ann Hematol DOI: 10.1007/bf00641048 sha: doc_id: 6860 cord_uid: a3b8hyyr file: cache/cord-007577-f1jzbtjj.json key: cord-007577-f1jzbtjj authors: Raphael Shulman, N. title: Hepatitis-associated antigen date: 2006-09-18 journal: Am J Med DOI: 10.1016/s0002-9343(70)80133-4 sha: doc_id: 7577 cord_uid: f1jzbtjj file: cache/cord-009322-7l7slziv.json key: cord-009322-7l7slziv authors: Kraetsch, Hans-Georg; Rascu, Astrid; Kalden, Joachim Richard; Manger, Bernhard title: Verlauf und prognostische Parameter bei Still-Syndrom des Erwachsenen: Eigene Erfahrungen und Literaturübersicht date: 1997 journal: Med Klin (Munich) DOI: 10.1007/bf03044666 sha: doc_id: 9322 cord_uid: 7l7slziv file: cache/cord-009575-bd67ph64.json key: cord-009575-bd67ph64 authors: Berr, C.; Puel, J.; Clanet, M.; Ruidavets, J. B.; Mas, J. L.; Alperovitch, A. title: Risk factors in multiple sclerosis: a population‐based case‐control study in Hautes‐Pyrénées, France date: 2009-01-29 journal: Acta Neurol Scand DOI: 10.1111/j.1600-0404.1989.tb03841.x sha: doc_id: 9575 cord_uid: bd67ph64 file: cache/cord-009507-l74c9x0n.json key: cord-009507-l74c9x0n authors: Singh, Amandeep; Moayedi, Siamak title: Clinicopathological Conference: Fever, Productive Cough, and Tachycardia in a 22‐year‐old Asian Male date: 2008-01-08 journal: Acad Emerg Med DOI: 10.1111/j.1553-2712.2004.tb01429.x sha: doc_id: 9507 cord_uid: l74c9x0n file: cache/cord-010078-8lkkez3n.json key: cord-010078-8lkkez3n authors: nan title: Invited Speakers date: 2010-11-24 journal: Respirology DOI: 10.1111/j.1440-1843.2010.01863.x sha: doc_id: 10078 cord_uid: 8lkkez3n file: cache/cord-009571-mygj2nd4.json key: cord-009571-mygj2nd4 authors: nan title: Proceedings of the 42nd annual meeting of the american rheumatism association a section of the arthritis foundation june 1 & 2, 1978 new york city abstracts of papers presented date: 2005-11-23 journal: Arthritis Rheum DOI: 10.1002/art.1780210508 sha: doc_id: 9571 cord_uid: mygj2nd4 file: cache/cord-010487-wncgecld.json key: cord-010487-wncgecld authors: Rinella, Mary E.; Noureddin, Mazen title: STELLAR 3 and STELLAR 4: Lessons From the Fall of Icarus date: 2020-04-30 journal: J Hepatol DOI: 10.1016/j.jhep.2020.04.034 sha: doc_id: 10487 cord_uid: wncgecld file: cache/cord-006854-o2e5na78.json key: cord-006854-o2e5na78 authors: nan title: Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date: 2018-04-20 journal: Surg Endosc DOI: 10.1007/s00464-018-6121-4 sha: doc_id: 6854 cord_uid: o2e5na78 file: cache/cord-009982-zgbu46fo.json key: cord-009982-zgbu46fo authors: Cies, Jeffrey J.; Moore, Wayne S.; Enache, Adela; Chopra, Arun title: Peramivir for Influenza A and B Viral Infections: A Pharmacokinetic Case Series date: 2019-10-04 journal: Pharmacotherapy DOI: 10.1002/phar.2330 sha: doc_id: 9982 cord_uid: zgbu46fo file: cache/cord-006466-e1phpqes.json key: cord-006466-e1phpqes authors: nan title: 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2018-04-23 journal: J Clin Immunol DOI: 10.1007/s10875-018-0485-z sha: doc_id: 6466 cord_uid: e1phpqes file: cache/cord-010856-3g0123lk.json key: cord-010856-3g0123lk authors: Araghi, Ariyan S.; Harris, Yasmin; Kyzas, Panayiotis title: An audit to analyse the two-week wait pathway at an oral cancer specialist district general hospital date: 2020-05-08 journal: Br Dent J DOI: 10.1038/s41415-020-1449-2 sha: doc_id: 10856 cord_uid: 3g0123lk file: cache/cord-009667-8r8j0h08.json key: cord-009667-8r8j0h08 authors: Cao, Bin; Huang, Yi; She, Dan‐Yang; Cheng, Qi‐Jian; Fan, Hong; Tian, Xin‐Lun; Xu, Jin‐Fu; Zhang, Jing; Chen, Yu; Shen, Ning; Wang, Hui; Jiang, Mei; Zhang, Xiang‐Yan; Shi, Yi; He, Bei; He, Li‐Xian; Liu, You‐Ning; Qu, Jie‐Ming title: Diagnosis and treatment of community‐acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association date: 2017-09-26 journal: Clin Respir J DOI: 10.1111/crj.12674 sha: doc_id: 9667 cord_uid: 8r8j0h08 file: cache/cord-010658-67k8pthy.json key: cord-010658-67k8pthy authors: Bernard, Andie title: PC-FACS May 2020 for July 2020 Issue date: 2020-05-07 journal: J Pain Symptom Manage DOI: 10.1016/j.jpainsymman.2020.05.001 sha: doc_id: 10658 cord_uid: 67k8pthy file: cache/cord-010261-sy7esszi.json key: cord-010261-sy7esszi authors: Tenenbein, Milton; Israels, Sara J. title: Early coagulopathy in severe iron poisoning date: 2006-08-17 journal: J Pediatr DOI: 10.1016/s0022-3476(88)80381-0 sha: doc_id: 10261 cord_uid: sy7esszi file: cache/cord-010999-u2guhh3h.json key: cord-010999-u2guhh3h authors: Blackstone, Eric; Daly, Barbara J.; Griggins, Cynthia title: Making Medical Decisions for Incapacitated Patients Without Proxies: Part II date: 2019-11-06 journal: HEC Forum DOI: 10.1007/s10730-019-09388-2 sha: doc_id: 10999 cord_uid: u2guhh3h file: cache/cord-009697-dq4y89ab.json key: cord-009697-dq4y89ab authors: Yuen, Eddie; Kam, Chak Wah; Rainer, Timothy H title: Role of absolute lymphocyte count in the screening of patients with suspected SARS date: 2003-07-25 journal: Emerg Med (Fremantle) DOI: 10.1046/j.1442-2026.2003.00486_3.x sha: doc_id: 9697 cord_uid: dq4y89ab file: cache/cord-011138-y9v5ivzg.json key: cord-011138-y9v5ivzg authors: Hatchimonji, Justin S.; Dumas, Ryan P.; Kaufman, Elinore J.; Scantling, Dane; Stoecker, Jordan B.; Holena, Daniel N. title: Questioning dogma: does a GCS of 8 require intubation? date: 2020-05-07 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-020-01383-4 sha: doc_id: 11138 cord_uid: y9v5ivzg file: cache/cord-010477-g754gjvh.json key: cord-010477-g754gjvh authors: Carney, Kevin P.; Crespin, Ann; Woerly, Gray; Brethouwer, Nicholas; Baucum, Jeff; DiStefano, Michael C. title: A Front-end Redesign With Implementation of a Novel “Intake” System to Improve Patient Flow in a Pediatric Emergency Department date: 2020-02-27 journal: Pediatr Qual Saf DOI: 10.1097/pq9.0000000000000263 sha: doc_id: 10477 cord_uid: g754gjvh file: cache/cord-010844-y26y5myb.json key: cord-010844-y26y5myb authors: Lessing, Noah L.; Lazaro, Albert; Zuckerman, Scott L.; Leidinger, Andreas; Rutabasibwa, Nicephorus; Shabani, Hamisi K.; Härtl, Roger title: Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why? date: 2020-04-29 journal: Spinal Cord DOI: 10.1038/s41393-020-0474-y sha: doc_id: 10844 cord_uid: y26y5myb file: cache/cord-011159-k2kca8zl.json key: cord-011159-k2kca8zl authors: Kamel, Toufik; Helms, Julie; Janssen-Langenstein, Ralf; Kouatchet, Achille; Guillon, Antoine; Bourenne, Jeremy; Contou, Damien; Guervilly, Christophe; Coudroy, Rémi; Hoppe, Marie Anne; Lascarrou, Jean Baptiste; Quenot, Jean Pierre; Colin, Gwenhaël; Meng, Paris; Roustan, Jérôme; Cracco, Christophe; Nay, Mai-Anh; Boulain, Thierry title: Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study date: 2020-01-07 journal: Intensive Care Med DOI: 10.1007/s00134-019-05896-4 sha: doc_id: 11159 cord_uid: k2kca8zl file: cache/cord-009713-sxd4t2tz.json key: cord-009713-sxd4t2tz authors: nan title: Poster Presentations date: 2020-01-10 journal: Dev Med Child Neurol DOI: 10.1111/dmcn.14411 sha: doc_id: 9713 cord_uid: sxd4t2tz file: cache/cord-009788-bc6sc2rc.json key: cord-009788-bc6sc2rc authors: Ferguson, J. K. title: Preventing healthcare‐associated infection: risks, healthcare systems and behaviour date: 2009-09-17 journal: Intern Med J DOI: 10.1111/j.1445-5994.2009.02004.x sha: doc_id: 9788 cord_uid: bc6sc2rc file: cache/cord-010036-6czkzek0.json key: cord-010036-6czkzek0 authors: Lorentz, I T; Subramaniam, S Shanthi; Yiannikas, C title: Treatment of idiopathic spasmodic torticollis with botulinum‐A toxin: a pilot study of 19 patients date: 1990-05-01 journal: Med J Aust DOI: 10.5694/j.1326-5377.1990.tb125354.x sha: doc_id: 10036 cord_uid: 6czkzek0 file: cache/cord-006870-f5w6fw6q.json key: cord-006870-f5w6fw6q authors: nan title: Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date: 2017-09-19 journal: Neurocrit Care DOI: 10.1007/s12028-017-0465-9 sha: doc_id: 6870 cord_uid: f5w6fw6q file: cache/cord-010929-d598h08w.json key: cord-010929-d598h08w authors: Kashiwagi, Hirokazu; Kuwana, Masataka; Hato, Takaaki; Takafuta, Toshiro; Fujimura, Kingo; Kurata, Yoshiyuki; Murata, Mitsuru; Tomiyama, Yoshiaki title: Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision date: 2020-01-02 journal: Int J Hematol DOI: 10.1007/s12185-019-02790-z sha: doc_id: 10929 cord_uid: d598h08w file: cache/cord-010141-955r29sd.json key: cord-010141-955r29sd authors: Sibila, Oriol; Rodrigo-Troyano, Ana; Torres, Antoni title: Nonantibiotic Adjunctive Therapies for Community-Acquired Pneumonia (Corticosteroids and Beyond): Where Are We with Them? date: 2016-12-17 journal: Semin Respir Crit Care Med DOI: 10.1055/s-0036-1593538 sha: doc_id: 10141 cord_uid: 955r29sd file: cache/cord-006849-vgjz74ts.json key: cord-006849-vgjz74ts authors: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 journal: Surg Endosc DOI: 10.1007/s00464-019-07109-x sha: doc_id: 6849 cord_uid: vgjz74ts file: cache/cord-010416-u0yo0lk6.json key: cord-010416-u0yo0lk6 authors: Tejada, Sofia; Campogiani, Laura; Solé-Lleonart, Candela; Rello, Jordi title: Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials date: 2020-04-28 journal: Adv Ther DOI: 10.1007/s12325-020-01347-5 sha: doc_id: 10416 cord_uid: u0yo0lk6 file: cache/cord-010461-un9pls28.json key: cord-010461-un9pls28 authors: Manohar, Sujal; McLeod, Crystal title: A Three-part Quality Improvement Initiative to Increase Patient Satisfaction and Reduce Appointment Time date: 2020-03-09 journal: Pediatr Qual Saf DOI: 10.1097/pq9.0000000000000277 sha: doc_id: 10461 cord_uid: un9pls28 file: cache/cord-009967-fyqc5bat.json key: cord-009967-fyqc5bat authors: Gleckman, Richard; Gantz, Nelson M. title: Cost‐Effective Antibiotic Prescribing date: 2012-01-24 journal: Pharmacotherapy DOI: 10.1002/j.1875-9114.1983.tb03264.x sha: doc_id: 9967 cord_uid: fyqc5bat file: cache/cord-010564-7c9h16bi.json key: cord-010564-7c9h16bi authors: Unolt, Marta; Kammoun, Molka; Nowakowska, Beata; Graham, Gail E.; Crowley, T. Blaine; Hestand, Matthew S.; Demaerel, Wolfram; Geremek, Maciej; Emanuel, Beverly S.; Zackai, Elaine H.; Vermeesch, Joris R.; McDonald-McGinn, Donna title: Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition date: 2019-09-02 journal: Genet Med DOI: 10.1038/s41436-019-0645-4 sha: doc_id: 10564 cord_uid: 7c9h16bi file: cache/cord-010786-w3kjc6so.json key: cord-010786-w3kjc6so authors: Ghaderi, Sara; Berg-Hansen, Pål; Bakken, Inger Johanne; Magnus, Per; Trogstad, Lill; Håberg, Siri Eldevik title: Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway date: 2019-12-23 journal: Eur J Epidemiol DOI: 10.1007/s10654-019-00595-2 sha: doc_id: 10786 cord_uid: w3kjc6so file: cache/cord-010398-5wot7tix.json key: cord-010398-5wot7tix authors: Clauw, Daniel J. title: Perspectives on Fatigue from the Study of Chronic Fatigue Syndrome and Related Conditions date: 2010-05-31 journal: PM R DOI: 10.1016/j.pmrj.2010.04.010 sha: doc_id: 10398 cord_uid: 5wot7tix file: cache/cord-009664-kb9fnbgy.json key: cord-009664-kb9fnbgy authors: nan title: Oral presentations date: 2014-12-24 journal: Clin Microbiol Infect DOI: 10.1111/j.1469-0691.2009.02857.x sha: doc_id: 9664 cord_uid: kb9fnbgy file: cache/cord-010075-72jodunj.json key: cord-010075-72jodunj authors: nan title: Paediatric SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_12.x sha: doc_id: 10075 cord_uid: 72jodunj file: cache/cord-010460-pczs9alv.json key: cord-010460-pczs9alv authors: Caruso, Thomas J.; O’Connell, Chloe; Qian, Jimmy J.; Kung, Tiffany; Wang, Ellen; Kinnebrew, Susan; Pearson, Molly; Kist, Madison; Menendez, Maria; Rodriguez, Samuel T. title: Retrospective Review of the Safety and Efficacy of Virtual Reality in a Pediatric Hospital date: 2020-04-10 journal: Pediatr Qual Saf DOI: 10.1097/pq9.0000000000000293 sha: doc_id: 10460 cord_uid: pczs9alv file: cache/cord-011093-d9dbvbcy.json key: cord-011093-d9dbvbcy authors: Orange, Jordan S. title: How I Manage Natural Killer Cell Deficiency date: 2019-11-22 journal: J Clin Immunol DOI: 10.1007/s10875-019-00711-7 sha: doc_id: 11093 cord_uid: d9dbvbcy file: cache/cord-010921-yzv43e8l.json key: cord-010921-yzv43e8l authors: Kaye, Alan David; Chernobylsky, David J.; Thakur, Pankaj; Siddaiah, Harish; Kaye, Rachel J.; Eng, Lauren K.; Harbell, Monica W.; Lajaunie, Jared; Cornett, Elyse M. title: Dexmedetomidine in Enhanced Recovery After Surgery (ERAS) Protocols for Postoperative Pain date: 2020-04-02 journal: Curr Pain Headache Rep DOI: 10.1007/s11916-020-00853-z sha: doc_id: 10921 cord_uid: yzv43e8l file: cache/cord-010566-tciwtxud.json key: cord-010566-tciwtxud authors: Singh, Nina; Gayowski, Timothy; Wagener, Marilyn M.; Marino, Ignazio R. title: Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality date: 1998 journal: J Gastroenterol DOI: 10.1007/s005350050047 sha: doc_id: 10566 cord_uid: tciwtxud file: cache/cord-011360-1n998win.json key: cord-011360-1n998win authors: Zloto, Keren; Tirosh-Wagner, Tal; Bolkier, Yoav; Bar-Yosef, Omer; Vardi, Amir; Mishali, David; Paret, Gidi; Nevo-Caspi, Yael title: Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery date: 2019-11-15 journal: J Cardiovasc Transl Res DOI: 10.1007/s12265-019-09921-1 sha: doc_id: 11360 cord_uid: 1n998win file: cache/cord-011533-im78xwl8.json key: cord-011533-im78xwl8 authors: Gloude, Nicholas J.; Dandoy, Christopher E.; Davies, Stella M.; Myers, Kasiani C.; Jordan, Michael B.; Marsh, Rebecca A.; Kumar, Ashish; Bleesing, Jack; Teusink-Cross, Ashley; Jodele, Sonata title: Thinking Beyond HLH: Clinical Features of Patients with Concurrent Presentation of Hemophagocytic Lymphohistiocytosis and Thrombotic Microangiopathy date: 2020-05-23 journal: J Clin Immunol DOI: 10.1007/s10875-020-00789-4 sha: doc_id: 11533 cord_uid: im78xwl8 file: cache/cord-010027-r0tl01kq.json key: cord-010027-r0tl01kq authors: nan title: Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland date: 2015-09-15 journal: J Pathol DOI: 10.1002/path.4631 sha: doc_id: 10027 cord_uid: r0tl01kq file: cache/cord-011181-9nvwk04v.json key: cord-011181-9nvwk04v authors: Jakimovska, Vesna Miloshevska; Biering-Sørensen, Fin; Lidal, Ingeborg Beate; Kostovski, Emil title: Epidemiological characteristics and early complications after spinal cord injury in Former Yugoslav Republic of Macedonia date: 2019-08-19 journal: Spinal Cord DOI: 10.1038/s41393-019-0342-9 sha: doc_id: 11181 cord_uid: 9nvwk04v file: cache/cord-011296-nutl2ovk.json key: cord-011296-nutl2ovk authors: Wu, Venus Kit Sze; Fong, Christine; Walters, Andrew M.; Lele, Abhijit V. title: Prevalence, Clinical Characteristics, and Outcomes Related to Ventilator-Associated Events in Neurocritically Ill Patients date: 2020-01-23 journal: Neurocrit Care DOI: 10.1007/s12028-019-00910-5 sha: doc_id: 11296 cord_uid: nutl2ovk file: cache/cord-011413-yv4x8viu.json key: cord-011413-yv4x8viu authors: Shekar, Kiran; Badulak, Jenelle; Peek, Giles; Boeken, Udo; Dalton, Heidi J.; Arora, Lovkesh; Zakhary, Bishoy; Ramanathan, Kollengode; Starr, Joanne; Akkanti, Bindu; Antonini, M. Velia; Ogino, Mark T.; Raman, Lakshmi; Barret, Nicholas; Brodie, Daniel; Combes, Alain; Lorusso, Roberto; MacLaren, Graeme; Müller, Thomas; Paden, Matthew; Pellegrino, Vincent title: Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date: 2020-05-12 journal: ASAIO J DOI: 10.1097/mat.0000000000001193 sha: doc_id: 11413 cord_uid: yv4x8viu file: cache/cord-011255-9q2frk71.json key: cord-011255-9q2frk71 authors: Kippnich, Maximilian; Schorscher, Nora; Kredel, Markus; Markus, Christian; Eden, Lars; Gassenmaier, Tobias; Lock, Johann; Wurmb, Thomas title: Dual-room twin-CT scanner in multiple trauma care: first results after implementation in a level one trauma centre date: 2020-04-25 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-020-01374-5 sha: doc_id: 11255 cord_uid: 9q2frk71 file: cache/cord-011284-u4qmvz3c.json key: cord-011284-u4qmvz3c authors: Livingston, Nicholas A.; Berke, Danielle; Scholl, James; Ruben, Mollie; Shipherd, Jillian C. title: Addressing Diversity in PTSD Treatment: Clinical Considerations and Guidance for the Treatment of PTSD in LGBTQ Populations date: 2020-03-16 journal: Curr Treat Options Psychiatry DOI: 10.1007/s40501-020-00204-0 sha: doc_id: 11284 cord_uid: u4qmvz3c file: cache/cord-011725-t1jl4cy1.json key: cord-011725-t1jl4cy1 authors: Varma, Niraj; Marrouche, Nassir F; Aguinaga, Luis; Albert, Christine M; Arbelo, Elena; Choi, Jong-Il; Chung, Mina K; Conte, Giulio; Dagher, Lilas; Epstein, Laurence M; Ghanbari, Hamid; Han, Janet K; Heidbuchel, Hein; Huang, He; Lakkireddy, Dhanunjaya R; Ngarmukos, Tachapong; Russo, Andrea M; Saad, Eduardo B; Saenz Morales, Luis C; Sandau, Kristin E; Sridhar, Arun Raghav M; Stecker, Eric C; Varosy, Paul D title: HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date: 2020-06-11 journal: Europace DOI: 10.1093/europace/euaa187 sha: doc_id: 11725 cord_uid: t1jl4cy1 file: cache/cord-011712-fyrbe8tw.json key: cord-011712-fyrbe8tw authors: Venkatesan, Sudhir; Myles, Puja R; Bolton, Kirsty J; Muthuri, Stella G; Al Khuwaitir, Tarig; Anovadiya, Ashish P; Azziz-Baumgartner, Eduardo; Bajjou, Tahar; Bassetti, Matteo; Beovic, Bojana; Bertisch, Barbara; Bonmarin, Isabelle; Booy, Robert; Borja-Aburto, Victor H; Burgmann, Heinz; Cao, Bin; Carratala, Jordi; Chinbayar, Tserendorj; Cilloniz, Catia; Denholm, Justin T; Dominguez, Samuel R; Duarte, Pericles A D; Dubnov-Raz, Gal; Fanella, Sergio; Gao, Zhancheng; Gérardin, Patrick; Giannella, Maddalena; Gubbels, Sophie; Herberg, Jethro; Higuera Iglesias, Anjarath Lorena; Hoeger, Peter H; Hu, Xiao Yun; Islam, Quazi T; Jiménez, Mirela F; Keijzers, Gerben; Khalili, Hossein; Kusznierz, Gabriela; Kuzman, Ilija; Langenegger, Eduard; Lankarani, Kamran B; Leo, Yee-Sin; Libster, Romina P; Linko, Rita; Madanat, Faris; Maltezos, Efstratios; Mamun, Abdullah; Manabe, Toshie; Metan, Gokhan; Mickiene, Auksė; Mikić, Dragan; Mohn, Kristin G I; Oliva, Maria E; Ozkan, Mehpare; Parekh, Dhruv; Paul, Mical; Rath, Barbara A; Refaey, Samir; Rodríguez, Alejandro H; Sertogullarindan, Bunyamin; Skręt-Magierło, Joanna; Somer, Ayper; Talarek, Ewa; Tang, Julian W; To, Kelvin; Tran, Dat; Uyeki, Timothy M; Vaudry, Wendy; Vidmar, Tjasa; Zarogoulidis, Paul; Nguyen-Van-Tam, Jonathan S title: Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection date: 2020-02-01 journal: J Infect Dis DOI: 10.1093/infdis/jiz152 sha: doc_id: 11712 cord_uid: fyrbe8tw file: cache/cord-011349-bykvn367.json key: cord-011349-bykvn367 authors: Rajasekaran, Raja Bhaskara; Palanisami, Dhanasekara Raja; Natesan, Rajkumar; Jayaramaraju, Dheenadhayalan; Rajasekaran, Shanmuganathan title: Megaprosthesis in distal femur nonunions in elderly patients—experience from twenty four cases date: 2019-08-07 journal: Int Orthop DOI: 10.1007/s00264-019-04383-1 sha: doc_id: 11349 cord_uid: bykvn367 file: cache/cord-011483-zc6ve6le.json key: cord-011483-zc6ve6le authors: Leclerc, Angela M.; Riker, Richard R.; Brown, Caitlin S.; May, Teresa; Nocella, Kristina; Cote, Jennifer; Eldridge, Ashley; Seder, David B.; Gagnon, David J. title: Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients date: 2020-05-20 journal: Neurocrit Care DOI: 10.1007/s12028-020-00986-4 sha: doc_id: 11483 cord_uid: zc6ve6le file: cache/cord-011297-4um9w2dx.json key: cord-011297-4um9w2dx authors: Brunker, Lucille; Hirst, Priscilla; Schlesinger, Joseph J. title: New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report date: 2019-11-28 journal: SN Compr Clin Med DOI: 10.1007/s42399-019-00185-z sha: doc_id: 11297 cord_uid: 4um9w2dx file: cache/cord-011975-8vl45xb7.json key: cord-011975-8vl45xb7 authors: Keser, Tobias; Kofler, Mario; Katzmayr, Mariella; Schiefecker, Alois J.; Rass, Verena; Ianosi, Bogdan A.; Lindner, Anna; Gaasch, Maxime; Beer, Ronny; Rhomberg, Paul; Schmutzhard, Erich; Pfausler, Bettina; Helbok, Raimund title: Risk Factors for Dysphagia and the Impact on Outcome After Spontaneous Subarachnoid Hemorrhage date: 2019-11-15 journal: Neurocrit Care DOI: 10.1007/s12028-019-00874-6 sha: doc_id: 11975 cord_uid: 8vl45xb7 file: cache/cord-010088-s9tfvtao.json key: cord-010088-s9tfvtao authors: nan title: Oral Abstracts date: 2013-11-01 journal: Vox Sang DOI: 10.1111/vox.12100_1 sha: doc_id: 10088 cord_uid: s9tfvtao file: cache/cord-011512-gw2sk90q.json key: cord-011512-gw2sk90q authors: Houlston, E. title: A simple pleasure date: 2020-05-22 journal: Br Dent J DOI: 10.1038/s41415-020-1683-7 sha: doc_id: 11512 cord_uid: gw2sk90q file: cache/cord-012025-faj682bp.json key: cord-012025-faj682bp authors: Savioli, Felicio; Rocha, Leonardo Lima title: Coagulation profile in severe COVID-19 patients: what do we know so far? date: 2020 journal: Rev Bras Ter Intensiva DOI: 10.5935/0103-507x.20200031 sha: doc_id: 12025 cord_uid: faj682bp file: cache/cord-011649-3dlsy8fl.json key: cord-011649-3dlsy8fl authors: Limoncelli, Janine; Marino, Tambudzia; Smetana, Roy; Sanchez-Barranco, Pablo; Brous, Mary; Cantwell, Kevin; Russ, Mark J.; Fogarty Mack, Patricia title: General Anesthesia Recommendations for Electroconvulsive Therapy During the Coronavirus Disease 2019 Pandemic date: 2020-06-12 journal: J ECT DOI: 10.1097/yct.0000000000000705 sha: doc_id: 11649 cord_uid: 3dlsy8fl file: cache/cord-011221-rhyxp4v5.json key: cord-011221-rhyxp4v5 authors: Fu, Chih-Yuan; Bajani, Francesco; Bokhari, Marissa; Tatebe, Leah C.; Starr, Frederick; Messer, Thomas; Kaminsky, Matthew; Dennis, Andrew; Schlanser, Victoria; Mis, Justin; Toor, Rubinder; Poulakidas, Stathis; Bokhari, Faran title: Obesity is Associated with Worse Outcomes Among Abdominal Trauma Patients Undergoing Laparotomy: A Propensity-Matched Nationwide Cohort Study date: 2019-11-11 journal: World J Surg DOI: 10.1007/s00268-019-05268-5 sha: doc_id: 11221 cord_uid: rhyxp4v5 file: cache/cord-012115-hpsxi9ay.json key: cord-012115-hpsxi9ay authors: Archie, Patrick; Bruera, Eduardo; Cohen, Lorenzo title: Music-based interventions in palliative cancer care: a review of quantitative studies and neurobiological literature date: 2013-05-30 journal: Support Care Cancer DOI: 10.1007/s00520-013-1841-4 sha: doc_id: 12115 cord_uid: hpsxi9ay file: cache/cord-012117-c693oefo.json key: cord-012117-c693oefo authors: Diaz-Padilla, Ivan; Hirte, Hal; Oza, Amit M.; Clarke, Blaise A.; Cohen, Brenda; Reedjik, Michael; Zhang, Tong; Kamel-Reid, Suzanne; Ivy, S. Percy; Hotte, Sebastien J.; Razak, Albiruni A. R.; Chen, Eric X.; Brana, Irene; Wizemann, Monika; Wang, Lisa; Siu, Lillian L.; Bedard, Philippe L. title: A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors date: 2013-10-01 journal: Invest New Drugs DOI: 10.1007/s10637-013-0001-5 sha: doc_id: 12117 cord_uid: c693oefo file: cache/cord-011188-59hn9wsv.json key: cord-011188-59hn9wsv authors: Bruce, Lori title: A Pot Ignored Boils On: Sustained Calls for Explicit Consent of Intimate Medical Exams date: 2020-03-09 journal: HEC Forum DOI: 10.1007/s10730-020-09399-4 sha: doc_id: 11188 cord_uid: 59hn9wsv file: cache/cord-011793-hlktpla4.json key: cord-011793-hlktpla4 authors: Rice, Todd W.; Janz, David R. title: In Defense of Evidence-based Medicine for the Treatment of COVID-19 Acute Respiratory Distress Syndrome date: 2020-07-17 journal: Ann Am Thorac Soc DOI: 10.1513/annalsats.202004-325ip sha: doc_id: 11793 cord_uid: hlktpla4 file: cache/cord-010933-xuztu95a.json key: cord-010933-xuztu95a authors: Davis, Samuel; Fard, Nasser title: Theoretical bounds and approximation of the probability mass function of future hospital bed demand date: 2018-11-06 journal: Health Care Manag Sci DOI: 10.1007/s10729-018-9461-7 sha: doc_id: 10933 cord_uid: xuztu95a file: cache/cord-011062-ukz4hnmy.json key: cord-011062-ukz4hnmy authors: nan title: Poster date: 2020-03-11 journal: J Frailty Aging DOI: 10.14283/jfa.2020.9 sha: doc_id: 11062 cord_uid: ukz4hnmy file: cache/cord-011103-sstpidvk.json key: cord-011103-sstpidvk authors: Younan, Duraid; Delozier, Sarah J.; Adamski, John; Loudon, Andrew; Violette, Aisha; Ustin, Jeffrey; Tinkoff, Glen; Moorman, Matthew L.; McQuay, Nathaniel title: Factors Predictive of Ventilator-associated Pneumonia in Critically Ill Trauma Patients date: 2019-11-26 journal: World J Surg DOI: 10.1007/s00268-019-05286-3 sha: doc_id: 11103 cord_uid: sstpidvk file: cache/cord-012037-9kmul7he.json key: cord-012037-9kmul7he authors: Veenis, J. F.; Brugts, J. J. title: Remote monitoring of chronic heart failure patients: invasive versus non-invasive tools for optimising patient management date: 2019-11-19 journal: Neth Heart J DOI: 10.1007/s12471-019-01342-8 sha: doc_id: 12037 cord_uid: 9kmul7he file: cache/cord-012459-tge08va0.json key: cord-012459-tge08va0 authors: Matthews, Laura J.; O-Connor, Michael; Chaggar, Rajinder Singh; Vaughan, David title: Airway Alert Bracelets: Enhancing Safety in the Coronavirus Disease 2019 Era date: 2020-08-18 journal: Anesth Analg DOI: 10.1213/ane.0000000000005165 sha: doc_id: 12459 cord_uid: tge08va0 file: cache/cord-011327-zsoc4wec.json key: cord-011327-zsoc4wec authors: Martin-Loeches, Ignacio; Leone, Marc; Einav, Sharon title: Antibiotic prophylaxis in the ICU: to be or not to be administered for patients undergoing procedures? date: 2019-11-28 journal: Intensive Care Med DOI: 10.1007/s00134-019-05870-0 sha: doc_id: 11327 cord_uid: zsoc4wec file: cache/cord-011302-pfepyvaw.json key: cord-011302-pfepyvaw authors: Edlmann, Ellie; Whitfield, Peter C. title: The changing face of neurosurgery for the older person date: 2020-04-25 journal: J Neurol DOI: 10.1007/s00415-020-09854-9 sha: doc_id: 11302 cord_uid: pfepyvaw file: cache/cord-012665-fflye8a3.json key: cord-012665-fflye8a3 authors: Marques-Vidal, Pedro title: Statistical issues regarding the article by Liu et al. date: 2020-09-02 journal: Eur J Clin Nutr DOI: 10.1038/s41430-020-00730-3 sha: doc_id: 12665 cord_uid: fflye8a3 file: cache/cord-012778-yr8zuvw9.json key: cord-012778-yr8zuvw9 authors: Zhang, Lei; Li, Yan-ge; He, Shen; Zhang, Yan; Yu, Yi-min; Li, Yan; Wen, Hui; Qiao, Ying; Shen, Yi-feng; Li, Hua-fang title: Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China date: 2019-08-06 journal: Acta Pharmacol Sin DOI: 10.1038/s41401-019-0285-x sha: doc_id: 12778 cord_uid: yr8zuvw9 file: cache/cord-011875-ga0dzj3v.json key: cord-011875-ga0dzj3v authors: Tsolaki, Vasiliki; Zakynthinos, George E. title: Are Patients with COVID-19 Dying of or with Cardiac Injury? date: 2020-07-15 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202004-1083le sha: doc_id: 11875 cord_uid: ga0dzj3v file: cache/cord-013035-7sfj0czv.json key: cord-013035-7sfj0czv authors: Savinelli, Stefano; McCarthy, Cormac; Mallon, Patrick W. title: Reply date: 2020-09-20 journal: Respirology DOI: 10.1111/resp.13940 sha: doc_id: 13035 cord_uid: 7sfj0czv file: cache/cord-012469-6cvu5umd.json key: cord-012469-6cvu5umd authors: Lewis, Jayne; Shapiro, Johanna title: Speaking with Frankenstein date: 2020-08-21 journal: J Med Humanit DOI: 10.1007/s10912-020-09653-3 sha: doc_id: 12469 cord_uid: 6cvu5umd file: cache/cord-013149-y0dbhtef.json key: cord-013149-y0dbhtef authors: Wohlfarth, P.; Schellongowski, P. title: Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date: 2020-10-12 journal: Med Klin Intensivmed Notfmed DOI: 10.1007/s00063-020-00737-5 sha: doc_id: 13149 cord_uid: y0dbhtef file: cache/cord-012902-efprpk72.json key: cord-012902-efprpk72 authors: nan title: Abstracts from the 2020 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS) date: 2020-09-15 journal: J Hum Hypertens DOI: 10.1038/s41371-020-00410-6 sha: doc_id: 12902 cord_uid: efprpk72 file: cache/cord-013003-gxd29jxf.json key: cord-013003-gxd29jxf authors: Vora, Darshan; Schlaff, Cody D.; Rosner, Michael K. title: Surgical management of a complex case of Charcot arthropathy of the spine: a case report date: 2019-08-22 journal: Spinal Cord Ser Cases DOI: 10.1038/s41394-019-0217-5 sha: doc_id: 13003 cord_uid: gxd29jxf file: cache/cord-011836-zib8wkm2.json key: cord-011836-zib8wkm2 authors: Urman, Jesús M.; Herranz, José M.; Uriarte, Iker; Rullán, María; Oyón, Daniel; González, Belén; Fernandez-Urién, Ignacio; Carrascosa, Juan; Bolado, Federico; Zabalza, Lucía; Arechederra, María; Alvarez-Sola, Gloria; Colyn, Leticia; Latasa, María U.; Puchades-Carrasco, Leonor; Pineda-Lucena, Antonio; Iraburu, María J.; Iruarrizaga-Lejarreta, Marta; Alonso, Cristina; Sangro, Bruno; Purroy, Ana; Gil, Isabel; Carmona, Lorena; Cubero, Francisco Javier; Martínez-Chantar, María L.; Banales, Jesús M.; Romero, Marta R.; Macias, Rocio I.R.; Monte, Maria J.; Marín, Jose J. G.; Vila, Juan J.; Corrales, Fernando J.; Berasain, Carmen; Fernández-Barrena, Maite G.; Avila, Matías A. title: Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach date: 2020-06-21 journal: Cancers (Basel) DOI: 10.3390/cancers12061644 sha: doc_id: 11836 cord_uid: zib8wkm2 file: cache/cord-013116-n7auvqh3.json key: cord-013116-n7auvqh3 authors: Srinivas, A.; Moshkun, C.; Darcey, J. title: Testing the limits of UDCs date: 2020-10-09 journal: Br Dent J DOI: 10.1038/s41415-020-2226-y sha: doc_id: 13116 cord_uid: n7auvqh3 file: cache/cord-013105-tmhce7p5.json key: cord-013105-tmhce7p5 authors: Kalil, Andre C.; Timsit, Jean-Francois title: Less is more: critically ill status is not a carte blanche for unlimited antibiotic use date: 2020-10-09 journal: Intensive Care Med DOI: 10.1007/s00134-020-06260-7 sha: doc_id: 13105 cord_uid: tmhce7p5 file: cache/cord-013139-b32xg7y7.json key: cord-013139-b32xg7y7 authors: Colak, Fatma Kurt; Guleray, Naz; Azapagasi, Ebru; Yazıcı, Mutlu Uysal; Aksoy, Erhan; Ceylan, Nesrin title: An intronic variant in BRAT1 creates a cryptic splice site, causing epileptic encephalopathy without prominent rigidity date: 2020-10-10 journal: Acta Neurol Belg DOI: 10.1007/s13760-020-01513-0 sha: doc_id: 13139 cord_uid: b32xg7y7 file: cache/cord-013370-gktnz644.json key: cord-013370-gktnz644 authors: Abreu, Maria T; Peyrin-Biroulet, Laurent title: Providing Guidance During a Global Viral Pandemic for the Care of Patients With Inflammatory Bowel Disease date: 2020-10-21 journal: J Crohns Colitis DOI: 10.1093/ecco-jcc/jjaa116 sha: doc_id: 13370 cord_uid: gktnz644 file: cache/cord-012934-c6pbr64i.json key: cord-012934-c6pbr64i authors: Hao, Weiming; Zhao, Liping; Yu, Huiqian; Li, Huawei title: Vestibular prognosis in idiopathic sudden sensorineural hearing loss with vestibular dysfunction treated with oral or intratympanic glucocorticoids: a protocol for randomized controlled trial date: 2020-07-22 journal: Trials DOI: 10.1186/s13063-020-04579-6 sha: doc_id: 12934 cord_uid: c6pbr64i file: cache/cord-013148-qbxbndsl.json key: cord-013148-qbxbndsl authors: Manzano-Nunez, Ramiro; McGreevy, David; Orlas, Claudia P.; García, Alberto F.; Hörer, Tal M.; DuBose, Joseph; Ordoñez, Carlos A. title: Outcomes and management approaches of resuscitative endovascular balloon occlusion of the aorta based on the income of countries date: 2020-10-12 journal: World J Emerg Surg DOI: 10.1186/s13017-020-00337-w sha: doc_id: 13148 cord_uid: qbxbndsl file: cache/cord-012560-p5s0p7fd.json key: cord-012560-p5s0p7fd authors: Decavèle, Maxens; Gatulle, Nicolas; Weiss, Nicolas; Rivals, Isabelle; Idbaih, Ahmed; Demeret, Sophie; Mayaux, Julien; Dres, Martin; Morawiec, Elise; Hoang-Xuan, Khe; Similowski, Thomas; Demoule, Alexandre title: One-year survival of patients with high-grade glioma discharged alive from the intensive care unit date: 2020-08-29 journal: J Neurol DOI: 10.1007/s00415-020-10191-0 sha: doc_id: 12560 cord_uid: p5s0p7fd file: cache/cord-012518-ncrdwtdg.json key: cord-012518-ncrdwtdg authors: nan title: Abstractband DOG 2020 date: 2020-08-24 journal: Ophthalmologe DOI: 10.1007/s00347-020-01197-0 sha: doc_id: 12518 cord_uid: ncrdwtdg file: cache/cord-013589-3l8kar3k.json key: cord-013589-3l8kar3k authors: Doummar, Diane; Dentel, Christel; Lyautey, Romane; Metreau, Julia; Keren, Boris; Drouot, Nathalie; Malherbe, Ludivine; Bouilleret, Viviane; Courraud, Jérémie; Valenti-Hirsch, Maria Paola; Minotti, Lorella; Dozieres-Puyravel, Blandine; Bär, Séverine; Scholly, Julia; Schaefer, Elise; Nava, Caroline; Wirth, Thomas; Nasser, Hala; de Salins, Marie; de Saint Martin, Anne; Warde, Marie Thérèse Abi; Kahane, Philippe; Hirsch, Edouard; Anheim, Mathieu; Friant, Sylvie; Chelly, Jamel; Mignot, Cyril; Rudolf, Gabrielle title: Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia date: 2020-05-28 journal: Eur J Hum Genet DOI: 10.1038/s41431-020-0641-9 sha: doc_id: 13589 cord_uid: 3l8kar3k file: cache/cord-014833-ax09x6gk.json key: cord-014833-ax09x6gk authors: Wu, Jia; Chen, Zhigang title: Data Decision and Transmission Based on Mobile Data Health Records on Sensor Devices in Wireless Networks date: 2016-06-20 journal: Wirel Pers Commun DOI: 10.1007/s11277-016-3438-y sha: doc_id: 14833 cord_uid: ax09x6gk file: cache/cord-007890-bie1veti.json key: cord-007890-bie1veti authors: nan title: ECC-4 Abstracts date: 2002-04-16 journal: Int J Antimicrob Agents DOI: 10.1016/s0924-8579(02)00033-x sha: doc_id: 7890 cord_uid: bie1veti file: cache/cord-013457-rqon1adg.json key: cord-013457-rqon1adg authors: De Cannière, Hélène; Smeets, Christophe J. P.; Schoutteten, Melanie; Varon, Carolina; Morales Tellez, John F.; Van Hoof, Chris; Van Huffel, Sabine; Groenendaal, Willemijn; Vandervoort, Pieter title: Short-Term Exercise Progression of Cardiovascular Patients throughout Cardiac Rehabilitation: An Observational Study date: 2020-09-29 journal: J Clin Med DOI: 10.3390/jcm9103160 sha: doc_id: 13457 cord_uid: rqon1adg file: cache/cord-014540-27hnlu5v.json key: cord-014540-27hnlu5v authors: Sutthiruk, Nantanit; Botti, Mari; Considine, Julie; Driscoll, Andrea; Hutchinson, Ana; Malathum, Kumthorn; Cucunawangsih, Cucunawangsih; Wiwing, Veronica; Puspitasari, Vivien; Shanmugakani, Rathina Kumar; Akeda, Yukihiro; Kodera, Takuya; Santanirand, Pitak; Tomono, Kazunori; Yamanaka, Takayuki; Moriuchi, Hiroyuki; Kitajima, Hiroyuki; Horikoshi, Yuho; Lavrinenko, Alyona; Azizov, Ilya; Tabriz, Nurlan; Kozhamuratov, Margulan; Serbo, Yekatherine; Yang, Dahae; Lee, Woonhyoung; Bae, Il Kwon; Lee, Jae Hyun; Lee, Hyukmin; Kim, Jung Ok; Jeong, Seok Hoon; Lee, Kyungwon; Peremalo, Thiba; Madhavan, Priya; Hamzah, Sharina; Than, Leslie; Wong, Eng Hwa; Desa, Mohd Nasir Mohd; Ng, Kee Peng; Geronimo, Marionne; Tayzon, Maria Fe; Maño, Maria Jesusa; Chow, Angela; Hon, Pei-Yun; Win, Mar-Kyaw; Ang, Brenda; Leo, Yee-Sin; Chow, Angela; Hon, Pei-Yun; See, Tina; Ang, Brenda; Marin, Rocio Alvarez; de Sousa, Marta Aires; Kieffer, Nicolas; Nordmann, Patrice; Poirel, Laurent; Laochareonsuk, Wison; Petyu, Sireekul; Wanasitchaiwat, Pawin; Thana, Sutasinee; Bunyaphongphan, Chollathip; Boonsomsuk, Woranan; Maneepongpermpoon, Pakpoom; Jamulitrat, Silom; Sureshkumar, Dorairajan; Supraja, Kalyanaraman; Sharmila, Soundararajan; Cucunawangsih, Cucunawangsih; Setiawan, Benny; Lumbuun, Nicolaski; Nakayama, Haruo; Ota, Toshiko; Shirane, Naoko; Matuoka, Chikako; Kodama, Kentaro; Ohtsuka, Masanobu; Bacolcol, Silverose Ann Andales; Velmonte, Melecia; Alde, Allan; Chavez, Keithleen; Esteban, Arlene Joy; Lee, Aisa Jensen; Hsieh, Tai-Chin; Shio-ShinJean; Huang, Huey-Jen; Huang, Shu-Ju; Huang, Yu-Huan; Cheng, Pei-Chen; Yu, Su-Fang; Tsao, Shih-Ming; Lee, Yuan-Ti; Li, Chien-Feng; Lu, Min-Chi; Pruetpongpun, Nattapol; Khawcharoenporn, Thana; Damronglerd, Pansachee; Suwantarat, Nuntra; Apisarnthanarak, Anucha; Rutjanawech, Sasinuch; Cushinotto, Lisa; McBride, Patty; Williams, Harding; Liu, Hans; Hang, Phan Thi; Anh, Dinh Pham Phuong; Le, Ngai; Khu, Dung; Nguyen, Lam; Castillo, Roel Beltran; Sureshkumar, Dorairajan; Gopalakrishnan, Ram; Ramasubramanian, Venkatasubramanian; Sreevidya, Subramanian; Jayapradha, Ranganathan; Umetsu, Atsushi; Noda, Tetsuhiro; Hashimoto, Kenyuu; Hayashi, Akihiro; Kabashima, Mikie; Jadczak, Ursula; Elvelund, Knut; Johnsen, Marit; Borgen, Bente; Lingaas, Egil; Mao, Chia-Hua; Chang, Fu-Chieh; Liu, Chang-Pan; Chao, Ru-Hui; Chang, Fu-chieh; Liu, Chang-pan; Pawapotako, Junpen; Prasertpan, Chadanan; Malaihuan, Wantanee; Uirungroj, Phisit; Prasertpan, Chadanan; Saenjum, Chalermpong; Ouirungrog, Teerapat; Uirungroj, Phisit; Borrell, Sue; Bass, Pauline; Worth, Leon; Xian-li, Zhao; Xiao-long, Li; Xue-hua, Yao; Wei, Ren; Zeng, Zhang Xia; Kong, Man Ying; Lai, Christopher Koon Chi; Lee, Suet Yi; Tsang, Ngai Chong; O’Donoghue, M. M.; Boost, M. V.; Suen, L. K. P.; Siu, G. K.; Mui, K. W.; Lai, C. K. C.; Tsang, D. N. C.; Sato, Yuka; Tateishi, Mariko; Mihashi, Mutsuko; Flor, Jose Paulo; Bautista, Marko; De Roxas, V. Jay; Vergara, Justine; Añonuevo, Nicolo Andrei; Kwek, Marion; Acuin, Jose; Sanchez, Anna Josea; Bathan, Avel; Jantan, Jamilah Binte; Guek, Chua Chor; Kian, Eu Chiow; Pirido, Pampe Anak; Aron, Nur Fadilah Binte Mohd; Estacio, Leah May; Palana, Francis Alvarez; Gracia, Michelle; Shamsuddin, Nur Syafiqah Binte; Castro, Kersten Timbad; Baloria, Madonna; Adam, Faezah Binte; Wei, Zhang; Fong, Poh Bee; Kalisvar, Marimuthu; Chow, Angela; Ang, Brenda; Chuang, I-Ju; Yi-ChunCho; Chiu, Yu-Fen; Chen, Lung-Chih; Lin, Yi-Chun; Dong, Shao-Xing; Lee, Yi-Chieh; Kuan, Hui-Chen; Lin, Hsin-Hua; Chi, Chia-Chun; Lu, Chin-Te; Chang, Fu-chieh; Liu, Chang-pan; Ya-Fen, Tang; Li-Hsiang, Su; Jien-Wei, Liu; Chao, Hsuehlan; ChangChien, PinRu; Chen, WeiFang; Lai, ChungHsu; Ara, Lutfe; Mowla, Syed Mohammad Niaz; Vashkar, Shaikh Mahmud Kamal; Chan, Wai Fong; ChunYau, Mabel Yin; LingChong, Karen Kam; OnLi, Tze; Kaur, Rajwinder; Yan, Ng Po; Chiu, Gloria Chor Shan; Cheung, Christina W. Y.; Ching, Patricia T. Y.; Ching, Radley H. C.; Lam, Conita H. S.; Kan, C. H.; Lee, Shirley S. Y.; Chen, C. P.; Chan, Regina F. Y.; Leung, Annie F. Y.; Wong, Isadora L. C.; Lam, S. S.; Chan, Queenie W. L.; Chan, Cecilia; Kaur, Rajwinder; Nematian, Seyed Sadeq Seyed; Palenik, Charles John; Askarian, Mehrdad; Nematian, Seyed Sadeq Seyed; Palenik, Charles John; Hatam, Nahid; Askarian, Mehrdad; Nakamura, Itaru; Fujita, Hiroaki; Tsukimori, Ayaka; Kobayashi, Takehito; Sato, Akihiro; Fukushima, Shinji; Matsumoto, Tetsuya; Flor, Jose Paulo; Añonuevo, Nicolo Andrei; Bautista, Marko; Vergara, Justine; De Roxas, V. James; Kwek, Marion; Flor, Jose Paulo; Bautista, Marko; Vergara, Justine; De Roxas, V James; AndreiAñonuevo, Nicolo; Kwek, Marion; Ho, Yeng May; Kum, Jia Qi; Poh, Bee Fong; Marimuthu, Kalisvar; Ang, Brenda; Liu, Tzu-Yin; Chu, Sin-Man; Chen, Hui-Zhu; Chen, Tun-chieh; Chen, Yichun; Tsao, Ya-Ching; Skuntaniyom, Sumawadee; Malathum, Kumthorn; Tipluy, Pirawadee; Paengta, Sangwan; wongsaen, Ratchanee; thanomphan, Sutthiphun; Tariyo, Samettanet; Thongchuea, Buachan; Khamfu, Pattama; Thanomphan, Sutthiphan; Songtaweesin, Wipaporn Natalie; Anugulruengkit, Suvaporn; Samransamruajkit, Rujipat; Sosothikul, Darintr; Tansrijitdee, Ornanong; Nakphunsung, Anry; Srimuan, Patchareeyawan; Sophonphan, Jirachaya; ThanyaweePuthanakit; Payuk, Kunyanut; Picheansathian, Wilawan; Viseskul, Nongkran; DeNardo, Elizabeth; Leslie, Rachel; Cartner, Todd; Barbosa, Luciana; Werner, Heinz-Peter; Brill, Florian H. H.; Kawagoe, Julia Yaeko; De Nardo, Elizabeth; Wilson, Sarah Edmonds-; Macinga, David; Mays-Suko, Patricia; Duley, Collette; Hang, Phan Thi; Hang, Tran Thi Thuy; Hanh, Tran Thi My; Gordon, Christopher; Sureshkumar, Dorairajan; Durairaj, Roopa; Rohit, Anusha; Saravanakumar, Saujanya; Hemalatha, Jothymani; Hirano, Ryuichi; Sakamoto, Yuichi; Yamamoto, Shoji; Tachibana, Naoki; Miura, Miho; Hieda, Fumiyo; Sakai, Yoshiro; Watanabe, Hiroshi; Velmonte, Melecia; Bacolcol, Silverose Ann; Alde, Allan; Chavez, Keitleen; Esteban, Arlene Joy; Lee, Aisa Jensen; Chow, Angela; Lim, Jia-Wei; Hon, Pei-Yun; Hein, Aung-Aung; Tin, Grace; Lim, Vanessa; Ang, Brenda; Chow, Angela; Hein, Aung-Aung; Lim, Jia-Wei; Hon, Pei-Yun; Lim, Vanessa; Tin, Grace; Ang, Brenda; Chow, Angela; Tin, Grace; Hein, Aung-Aung; Lim, Vanessa; Lim, Jia-Wei; Hon, Pei-Yun; Ang, Brenda; Chao, Huwi-chun; Yeh, Chiu-Yin; Lo, Mei-feng; Chao, Huwi-chun; Piwpong, Chonlada; Rajborirug, Songyos; Preechawetchakul, Ploypailin; Pruekrattananapa, Yada; Sangsuwan, Tharntip; Jamulitrat, Silom; Wongsaen, Ratchanee; Paengta, Sungwan; Nilchon, Napatnun; Thanompan, Sutthipun; Tariyo, Samattanet; Le, Ngai; Khu, Dung; Kolesnichenko, Svetlana; Azizov, Ilya; Lavrinenko, Alyona; Tishkambayev, Yerbol; Lavrinenko, Alyona; Azizov, Ilya; Tishkambayev, Yerbol; Alibecov, Asylkhan; Kolesnichenko, Svetlana; Serbo, Yekaterina; Nam, Youngwon; Park, Jae Hyeon; Hong, Yun Ji; Kim, Taek Soo; Park, Jeong Su; Park, Kyoung Un; Kim, Eui-Chong; Aziegbemhin, Samuel Abumhere; Enabulele, Onaiwu; Tung, Yao-Shen; Chen, An-Chi; Huang, Shen-Min; Yang, Yui-Yein; Wu, Li-Hung; Lin, Chin-cheng; Chang, Fu-chieh; Liu, Chang-pan; Lien, Tzu Hao; Chang, Jia Hao; Huang, Yu Shan; Chen, Yi Shun; Saenjum, Chalermpong; Sirilun, Sasithorn; Ouirungrog, Teerapat; Ouirungroj, Phisit; Trakulsomboon, Suwanna; Prasajak, Patcharee; Kwok, Maryanne W. N.; Ng, Lady S. H.; Wong, Lindy M. T.; Poon, Lenina S. L.; Lai, Mary K. L.; Cheng, Holly H. S.; Fong, S. K.; Leung, Cindy F. Y.; Hasegawa, Jumpei; Shirakawa, Hiroki; Wakai, Sachiko; Mieno, Makiko; Hatakeyama, Shuji; Tateishi, Mariko; Mihashi, Mutsuko; Sato, Yuka; Saenjum, Chalermpong; Deeudom, Manu; Tharavichitkul, Prasit; Ouirungrog, Teerapat; Ouirungroj, Phisit; Chinniah, Terrence; Tan, Jackson; Prabu, Kavitha; Alam, Sartaj; Wynn, Aung Kyaw; Ahmad, Rashidah; Sidek, Amalina; Samsuddin, Dg Azizah; Ajis, Noraini; Ahmad, Aliyah; Magon, Susylawathi; Chu, Boon; Kuang, Jiqiu; Gao, Yan; Wang, Shoujun; Hao, Yunxiao; Liu, Rong; Li, Dongmei; Wang, Hui; Yan, Ng Po; Nishio, Hisanori; Mori, Hitomi; Morokuma, Yoshiko; Yamada, Takaaki; Kiyosuke, Makiko; Yasunaga, Sachie; Toyoda, Kazuhiro; Shimono, Nobuyuki; Babenko, Dmitriy; Turmuhambetova, Anar; Cheşcă, Antonella; Toleman, Mark A.; Babenko, Dmitriy; Turmuhambetova, Anar; Cheşcă, Antonella; Toleman, Mark A.; Babenko, Dmitriy; Turmuhambetova, Anar; Azizov, Ilya; Cheşcă, Antonella; Toleman, Mark A.; Akhmaltdinova, Lyudmila L.; Turmuhambetova, Anar; Cheşcă, Antonella; Babenko, Dmitriy; Magsakay, Mark Albert; Macatibag, Angelo; Tayzon, Maria Fe; Lerios, Jeannica Kriselle; Azizov, Ilya; Lavrineko, Alyona; Babenko, Dmitry; Sheck, Eugene; Edelstein, Mikhail; Liu, Tzu-Yin; Li, Lih-Yue; Chan, Chiung-Wen; Pan, Hui-Chuan; Chen, Tun-chieh; Vanishakije, Wipa; Jaikampun, Warisra; Cheng, Pei-Chen; Huang, Huey-Jen; Huang, Shu-Ju; Huang, Yu-Huan; Li, Su-Yin; Yu, Su-Fang; Li, Jian-Feng; Wu, Yu-Ping; Lee, Yuan-Ti; Lin, Chiao-Hui; Chang, Ping-Chin; Tariyo, Samatanet; Paengta, Sangwan; Wongsaen, Ratchanee; Thanompan, Suttsiphan; Skuntaniyom, Sumawadee; Malathum, Kumthorn; Sukkra, Suchada; Zaman, Khalequ; Zaman, Sheikh Farzana; Zaman, Farzana; Aziz, Asma; Faisal, Sayeed-Bin; Traskine, Magali; Ruiz-Guiñazú, Javier; Borys, Dorota; Zaman, Khalequ; Zaman, Sheikh Farzana; Zaman, Farzana; Aziz, Asma; Faisal, Sayeed-Bin; Traskine, Magali; Ruiz-Guiñazú, Javier; Borys, Dorota; Lam, Wendy Wai Yee; Chow, May; Choy, Lucy; Kam, Joseph; Salleh, Sharifah Azura; Yacob, Razila; Yusof, Siti Rokiah; Jalil, Nordiah Awang; Flor, Jose Paulo; Añonuevo, Nicolo Andrei; Bautista, Marko; De Roxas, V. Jay; Vergara, Justine; Millan, Maria Lourdes; Kwek, Marion; Acuin, Jose Lito; Lee, Aisa Jensen; Velmonte, Melecia A.; Bacolcol, Silverose Ann A.; Alde, Allan; Chavez, Keitleen; Esteban, Arlene Joy; Ting, Ching-I; Dissayasriroj, Sunisa; Chinniah, Terrence Rohan; Prabu, Kavitha; Ahmad, Rashidah; Magon, Susylawathi; DiniSuhaimi, Jauharatud; Mirasin, Aizzuddin; Morni, Nurul; Chu, Boon; Samsuddin, Azizah; Ahmad, Aliyah; Sidek, Amalina; Ajis, Noraini; AbuBakar, Amalina; Shafiee, Amanie; Safar, Julaini; Yan, Ng Po; Annie, Leung; Ling, Fung Yuk; Edna, Lau; Kristine, Luk; Shinomiya, Satoshi; Yamamoto, Kumiko; Kjiwara, Kayoko; Yamaguchi, Mitsuhiro; Chow, Angela; Tin, Grace; Zhang, Wei; Hon, Pei-Yun; Poh, Bee-Fong; Marimuthu, Kalisvar; Ang, Brenda; Chan, Ming-Chin; Wang, Chih-Chien; Huang, Shu-Ju; Huang, Huey-Jen; Yu, Su-Fang; Huang, Huan-Yu; Cheng, Pei-Chen; Li, Jian-Feng; Lee, Yuan-Ti; Lai, Chiung-Ling; Lu, Min-Chi; Kosol, Sajeerat; Sakolwirat, Wantana; Paepong, Patchanee; Jansanga, Sawalee; Jaisamoot, Pattarin; Thongnuanual, Nuttha; Srithong, Chittima; Somsakul, Somporn; Malathum, Kumthorn; Plongpunth, Sutima; Punpop, Mukkapon; Malathum, Porntip; Malathum, Kumthorn; Thanomphan, Sutthiphan; Wongsaen, Ratchanee; Peautiwat, Kulada; boon kirdram, Nattawipa; Picheansathian, Wilawan; Klunklin, Pimpaporn; Samethadka, Geetha; Suzuki, Naoko; Asada, Hitomi; Katayama, Masao; Komano, Atsushi; Sato, Akihiro; Nakamura, Itaru; Watanabe, Hidehiro; Matsumoto, Tetsuya; Seo, Hye Kyung; Hwang, Joo-Hee; Shin, Myoung Jin; Kim, Su Young; Kim, Eu Suk; Song, Kyoung-Ho; Kim, Hong Bin; Un, Lai-Si; Vong, Choi-Ian; Flor, Jose Paulo; Añonuevo, Nicolo Andrei; Bautista, Marko; De Roxas, V. James; Vergara, Justine; Kwek, Marion; Koh, Jocelyn; Agustinus, Sherly; Hassan, Rozita Bte Abu; Thinn, Yin Phyu; Ng, Benjamin; Tun, Soe Pyae; Ha, Su Mon Thi; Xiaoting, Xue; Li, Lin; Chuang, Leyland; Niroshika, Attanayaka Mudiyanselage Chulani; Perera, Kaluarachchige Anoma Kaluarachchi; Fernando, Dimingo Kankanamalage Diana Grace; Hemamala, Bodhipakshage Rohini; Yeh, Chiu-yin; Chao, Huwi-chun; Yang, Hui-Chun; Chiu, Hsiang-Ju; Shih, Ya-Ling; Chien, Yu-Shan; Lin, Wan-Yi; Pan, Chia-Yun; Chang, Ying-Yun; Yea, Chiu-Yuch; Chu, Ming-Hsien; Lee, Li-Chu; Chiu, Hsiang-Ju; Shih, Ya-Ling; Yang, Hui-Chun; Yu-Hsiu, Lin; Siao-Pei, Guo; Pak-On, Leung; Mei-Fe, Sie; Jyh-Jou, Chen; Yu-Hsiu, Lin; Yong-Yuan, Chang; Kuo, Shu-Yuan; Lin, Yu-Hsiu; Zhang, Ji-Sheng; Leung, Pak-On; Sie, Mei-Fe; Chen, Jyh-Jou; Chen, Yan-Ru; Lin, Yu-Hsiu; Chen, Ying-Ling; Taou, Chi-Fen; Chen, Hsiao-Shan; Tang, Hung-Jen; Chen, Shin Yu; Chen, Yin Yin; Der Wang, Fu; Shih, Tzu-Ping; Chen, Chin-Yu; Chen, Su-Jung; Wu, Mei-chi; Yang, Wan-ju; Chou, Mei-ling; Yu, Man-Ling; Li, Li-Chu; Chu, Cheng-Wei; Tsou, Wen-Hao; Wu, Wen-Chih; Cheng, Wen-Chi; Sun, Cho-Ching; Shih, Tzu-Ping; Chen, Chin-Yu; Lu, Shu-Hua; Chen, Su-Jung; Yang, Hsin-Ling; Lu, Cheng-Yu; Yu, Man-Ling; Li, Li-Chu; Chu, Cheng-Wei; Tsou, Wen-Hao; Wu, Wen-Chih; Cheng, Wen-Chi; Sun, Cho-Ching; Hirunprapakorn, Nitchawan; Malathum, Kumthorn; Apivanich, Sirilux; Pornmee, Ttipakorn; Beowsomboon, Chonnikarnt; Rajborirug, Songyos; Pruekrattananapa, Yada; Sangsuwan, Tharntip; Jamulitrat, Silom; Kumkoom, Itthaporn; Kasatpibal, Nongyao; Chitreecheur, Jittaporn; Kasatpibal, Nongyao; Whitney, JoAnne D.; Saokaew, Surasak; Kengkla, Kirati; Heitkemper, Margaret M.; Apisarnthanarak, Anucha; Muntajit, Thanomvong; Apivanich, Siriluk; Malathum, Kumthorn; Somsakul, Somporn; Phan, Hang Thi; Dinh, Anh Pham Phuong; Nguyen, Tuyet Thi Kim title: Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC): Bangkok, Thailand. 12-15 February 2017 date: 2017-02-22 journal: Antimicrob Resist Infect Control DOI: 10.1186/s13756-017-0176-1 sha: doc_id: 14540 cord_uid: 27hnlu5v file: cache/cord-014538-6a2pviol.json key: cord-014538-6a2pviol authors: Kamilia, Chtara; Regaieg, Kais; Baccouch, Najeh; Chelly, Hedi; Bahloul, Mabrouk; Bouaziz, Mounir; Jendoubi, Ali; Abbes, Ahmed; Belhaouane, Houda; Nasri, Oussama; Jenzri, Layla; Ghedira, Salma; Houissa, Mohamed; Belkadi, Kamal; Harti, Youness; Nsiri, Afak; Khaleq, Khalid; Hamoudi, Driss; Harrar, Rachid; Thieffry, Camille; Wallet, Frédéric; Parmentier-Decrucq, Erika; Favory, Raphaël; Mathieu, Daniel; Poissy, Julien; Lafon, Thomas; Vignon, Philippe; Begot, Emmanuelle; Appert, Alexandra; Hadj, Mathilde; Claverie, Paul; Matt, Morgan; Barraud, Olivier; François, Bruno; Jamoussi, Amira; Jazia, Amira Ben; Marhbène, Takoua; Lakhdhar, Dhouha; Khelil, Jalila Ben; Besbes, Mohamed; Goutay, Julien; Blazejewski, Caroline; Joly-Durand, Isabelle; Pirlet, Isabelle; Weillaert, Marie Pierre; Beague, Sebastien; Aziz, Soufi; Hafiane, Reda; Hattabi, Khalid; Bouhouri, Mohamed Aziz; Hammoudi, Driss; Fadil, Abdelaziz; Harrar, Rachid Al; Zerouali, Khalid; Medhioub, Fatma Kaaniche; Allela, Rania; Algia, Najla Ben; Cherif, Samar; Slaoui, Mohamed Taoufik; Boubia, Souhail; Hafiani, Y.; Khaoudi, A.; Cherkab, R.; Elallam, W.; Elkettani, C.; Barrou, L.; Ridaii, M.; Mehdi, Rihi El; Schimpf, Caroline; Mizrahi, Assaf; Pilmis, Benoît; Le Monnier, Alban; Tiercelet, Kelly; Cherin, Mélanie; Bruel, Cédric; Philippart, Francois; Bailly, Sébastien; Lucet, Jc; Lepape, Alain; L’hériteau, François; Aupée, Martine; Bervas, Caroline; Boussat, Sandrine; Berger-Carbonne, Anne; Machut, Anaïs; Savey, Anne; Timsit, Jean-François; Razazi, Keyvan; Rosman, Jérémy; de Prost, Nicolas; Carteaux, Guillaume; Jansen, Chloe; Decousser, Jean Winoc; Brun-Buisson, Christian; Dessap, Armand Mekontso; M’rad, Aymen; Ouali, Zouhour; Barghouth, Manel; Kouatchet, Achille; Mahieu, Rafael; Weiss, Emmanuel; Schnell, David; Zahar, Jean-Ralph; Artiguenave, Margaux; Sophie, Paktoris-Papine; Espinasse, Florence; Sayed, Faten El; Dinh, Aurélien; Charron, Cyril; Geri, Guillaume; Vieillard-Baron, Antoine; Repessé, Xavier; Kallel, Hatem; Mayence, Claire; Houcke, Stéphanie; Guegueniat, Pascal; Hommel, Didier; Dhifaoui, Kaouther; Hajjej, Zied; Fatnassi, Amira; Sellami, Walid; Labbene, Iheb; Ferjani, Mustapha; Dachraoui, Fahmi; Nakkaa, Sabrine; M’ghirbi, Abdelwaheb; Adhieb, Ali; Braiek, Dhouha Ben; Hraiech, Kmar; Ousji, Ali; Ouanes, Islem; Zaineb, Hammouda; Abdallah, Saousen Ben; Ouanes-Besbes, Lamia; Abroug, Fekri; Klein, Simon; Miquet, Mattéo; Thouret, Jean-Marc; Peigne, Vincent; Daban, Jean-Louis; Boutonnet, Mathieu; Lenoir, Bernard; Merhbene, Takoua; Derreumaux, Celine; Seguin, Thierry; Conil, Jean-Marie; Kelway, Charlotte; Blasco, Valery; Nafati, Cyril; Harti, Karim; Reydellet, Laurent; Albanese, Jacques; Aicha, Narjess Ben; Meddeb, Khaoula; Khedher, Ahmed; Ayachi, Jihene; Fraj, Nesrine; Sma, Nesrine; Chouchene, Imed; Boussarsar, Mohamed; Yedder, Soumaya Ben; Samoud, Walid; Radhouene, Bousselmi; Mariem, Bousselmi; Ammar, Asma; Cheikh, Asma Ben; Lakhal, Hend Ben; Khelfa, Messaouda; Hamdaoui, Yamina; Bouafia, Nabiha; Trampont, Timothée; Daix, Thomas; Legarçon, Vincent; Karam, Henri Hani; Pichon, Nicolas; Essafi, Fatma; Foudhaili, Nasreddine; Thabet, Hafedh; Blel, Youssef; Brahmi, Nozha; Ezzouine, Hanane; Kerrous, Mahmoud; Haoui, Saad El; Ahdil, Soufiane; Benslama, Abdellatif; Abidi, Khalid; Dendane, Tarek; Oussama, Ssouni; Belayachi, Jihane; Madani, Naoufal; Abouqal, Redouane; Zeggwagh, Amine Ali; Ghadhoune, Hatem; Chaari, Anis; Jihene, Guissouma; Allouche, Hend; Trabelsi, Insaf; Brahmi, Habib; Samet, Mohamed; Ghord, Hatem El; Habiba, Ben Sik Ali; Hajer, Nouira; Tilouch, Najla; Yaakoubi, Sondes; Jaoued, Oussama; Gharbi, Rim; Hassen, Mohamed Fekih; Elatrous, Souheil; Arcizet, Julien; Leroy, Bertrand; Abdulmalack, Caroline; Renzullo, Catherine; Hamet, Maël; Doise, Jean-Marc; Coutet, Jérôme; Cheikh, Chaigar Mohammed; Quechar, Zakaria; Joris, Magalie; Beauport, Dimitri Titeca; Kontar, Loay; Lebon, Delphine; Gruson, Bérengère; Slama, Michel; Marolleau, Jean-Pierre; Maizel, Julien; Gorham, Julie; Ameye, Lieveke; Berghmans, Thierry; Paesmans, Marianne; Sculier, Jean-Paul; Meert, Anne-Pascale; Guillot, Max; Ledoux, Marie-Pierre; Braun, Thierry; Maestraggi, Quentin; Michard, Baptiste; Castelain, Vincent; Herbrecht, Raoul; Schneider, Francis; Couffin, Severine; Lobo, David; Mongardon, Nicolas; Dhonneur, Gilles; Mounier, Roman; Le Borgne, Pierrick; Couraud, Sophie; Herbrecht, Jean-Etienne; Boivin, Alexandra; Lefebvre, François; Bilbault, Pascal; Zelmat, Setti-Aouicha; Batouche, Djamila-Djahida; Mazour, Fatima; Chaffi, Belkacem; Benatta, Nadia; Sik, Ali Habiba; Talik, I.; Perrier, Maxime; Gouteix, Eliane; Koubi, Claude; Escavy, Annabelle; Guilbaut, Victoria; Fosse, Jean-Philippe; Jazia, Rahma Ben; Abdelghani, Ahmed; Cungi, Pierre-Julien; Bordes, Julien; Nguyen, Cédric; Pierrou, Candice; Cruc, Maximilien; Benois, Alain; Duprez, Frédéric; Bonus, Thierry; Cuvelier, Grégory; Ollieuz, Sandra; Machayekhi, Sharam; Paciorkowski, Frédéric; Reychler, Gregory; Coudroy, Remi; Thille, Arnaud W.; Drouot, Xavier; Diaz, Véronique; Meurice, Jean-Claude; Robert, René; Turki, Olfa; Ben, Hmida Chokri; Assefi, Mona; Deransy, Romain; Brisson, Hélène; Monsel, Antoine; Conti, Filomena; Scatton, Olivier; Langeron, Olivier; Ghezala, Hassen Ben; Snouda, Salah; Ben, Chiekh Imen; Kaddour, Moez; Armel, Anwar; Youness, Lafrikh; Abdelhak, Bensaid; Youssef, Miloudi; Najib, Al Harrar; Mustapha, Amouzoun; Noufel, Mtioui; Mohamed, Zamd; Salma, El Khayat; Ghizlane, Medkouri; Mohamed, Benghanam; Benyounes, Ramdani; Montini, Florent; Moschietto, Sébastien; Gregoire, Emilien; Claisse, Guillaume; Guiot, Julien; Morimont, Philippe; Krzesinski, Jean-Marie; Mariat, Christophe; Lambermont, Bernard; Cavalier, Etienne; Delanaye, Pierre; Benbernou, Soumia; Ilies, Sofiane; Azza, Abdelkader; Bouyacoub, Khalida; Louail, Meriem; Mokhtari-Djebli, Houria; Arrestier, Romain; Daviaud, Fabrice; Francois, Xavier Laborne; Brocas, Elsa; Choukroun, Gérald; Peñuelas, Oscar; Lorente, José-Angel; Cardinal-Fernandez, Pablo; Rodriguez, José-Maria; Aramburu, José-Antonio; Esteban, Andres; Frutos-Vivar, Fernando; Bitker, Laurent; Costes, Nicolas; Le Bars, Didier; Lavenne, Franck; Devouassoux, Mojgan; Richard, Jean-Christophe; Mechati, Malika; Gainnier, Marc; Papazian, Laurent; Guervilly, Christophe; Garnero, Aude; Arnal, Jean Michel; Roze, Hadrien; Richard, Jean Christophe; Repusseau, Benjamin; Dewitte, Antoine; Joannes-Boyau, Olivier; Ouattara, Alexandre; Harbouze, Nadia; Amine, A. M.; Olandzobo, A. G.; Herbland, Alexandre; Richard, Marie; Girard, Nicolas; Lambron, Lucile; Lesieur, Olivier; Wainschtein, Sarah; Hubert, Sidonie; Hugues, Albane; Tran, Marc; Bouillard, Philippe; Loteanu, Vlad; Leloup, Maxime; Laurent, Alexandra; Lheureux, Florent; Prestifilippo, Alessia; Cruz, Martin Delgado Maria; Romain, Rigal; Antonelli, Massimo; Blanch, Torra Lluis; Bonnetain, Franck; Grazzia-Bocci, Maria; Mancebo, Jordi; Samain, Emmanuel; Paul, Hebert; Capellier, Gilles; Zavgorodniaia, Taissa; Soichot, Marion; Malissin, Isabelle; Voicu, Sebastian; Garçon, Pierre; Goury, Antoine; Kerdjana, Lamia; Deye, Nicolas; Bourgogne, Emmanuel; Megarbane, Bruno; Mejri, Olfa; Hmida, Marwa Ben; Tannous, Salma; Chevillard, Lucie; Labat, Laurence; Risede, Patricia; Fredj, Hana; Léger, Maxime; Brunet, Marion; Le Roux, Gaël; Boels, David; Lerolle, Nicolas; Farah, Souaad; Amiel-Niemann, Hélène; Kubis, Nathalie; Declèves, Xavier; Peyraux, Nicoals; Baud, Frederic; Serafini, Micaela; Alvarez, Jean-Claude; Heinzelman, Annette; Jozwiak, Mathieu; Millasseau, Sandrine; Teboul, Jean-Louis; Alphonsine, Jean-Emmanuel; Depret, François; Richard, Nathalie; Attal, Pierre; Richard, Christian; Monnet, Xavier; Chemla, Denis; Jerbi, Salma; Khedhiri, Wafa; Necib, Hatem; Scarfo, Paolo; Chevalier, Charles; Piagnerelli, Michael; Lafont, Alexandre; Galy, Antoine; Mancia, Claire; Zerhouni, Amel; Tabeliouna, Kheira; Gaja, Ali; Hamrouni, Bassem; Malouch, Abir; Fourati, Sami; Messaoud, Rihab; Zarrouki, Youssef; Ziadi, Amra; Rhezali, Manal; Zouizra, Zahira; Boumzebra, Drissi; Samkaoui, Mohamed Abdennasser; Brunet, Jennifer; Canoville, Bertrand; Verrier, Pierre; Ivascau, Calin; Seguin, Amélie; Valette, Xavier; Du Cheyron, Damien; Daubin, Cedric; Bougouin, Wulfran; Aissaoui, Nadia; Lamhaut, Lionel; Jost, Daniel; Maupain, Carole; Beganton, Frankie; Bouglé, Adrien; Dumas, Florence; Marijon, Eloi; Jouven, Xavier; Cariou, Alain; Poirson, Florent; Chaput, Ulriikka; Beeken, Thomas; Maxime, Leclerc; Haikel, Oueslati; Vodovar, Dominique; Chelly, Jonathan; Marteau, Philippe; Chocron, Richard; Juvin, Philippe; Loeb, Thomas; Adnet, Frederic; Lecarpentier, Eric; Riviere, Antoine; De Cagny, Bertand; Soupison, Thierry; Privat, Elodie; Escutnaire, Joséphine; Dumont, Cyrielle; Baert, Valentine; Vilhelm, Christian; Hubert, Hervé; Leteurtre, Stéphane; Fresco, Marion; Bubenheim, Michael; Beduneau, Gaetan; Carpentier, Dorothée; Grange, Steven; Artaud-Macari, Elise; Misset, Benoit; Tamion, Fabienne; Girault, Christophe; Dumas, Guillaume; Chevret, Sylvie; Lemiale, Virginie; Mokart, Djamel; Mayaux, Julien; Pène, Frédéric; Nyunga, Martine; Perez, Pierre; Moreau, Anne-Sophie; Bruneel, Fabrice; Vincent, François; Klouche, Kada; Reignier, Jean; Rabbat, Antoine; Azoulay, Elie; Frat, Jean-Pierre; Ragot, Stéphanie; Constantin, Jean-Michel; Prat, Gwenael; Mercat, Alain; Boulain, Thierry; Demoule, Alexandre; Devaquet, Jérôme; Nseir, Saad; Charpentier, Julien; Argaud, Laurent; Beuret, Pascal; Ricard, Jean-Damien; Teiten, Christelle; Marjanovic, Nicolas; Palamin, Nicola; L’Her, Erwan; Bailly, Arthur; Boisramé-Helms, Julie; Champigneulle, Benoit; Kamel, Toufik; Mercier, Emmanuelle; Le Thuaut, Aurélie; Lascarrou, Jean-Baptiste; Rolle, Amélie; De Jong, Audrey; Chanques, Gérald; Jaber, Samir; Hariri, Geoffroy; Baudel, Jean-Luc; Dubée, Vincent; Preda, Gabriel; Bourcier, Simon; Joffre, Jeremie; Bigé, Naïke; Ait-Oufella, Hafid; Maury, Eric; Mater, Houda; Merdji, Hamid; Grimaldi, David; Rousseau, Christophe; Mira, Jean-Paul; Chiche, Jean-Daniel; Sedghiani, Ines; Benabderrahim, A.; Hamdi, Dhekra; Jendoubi, Asma; Cherif, Mohamed Ali; Hechmi, Youssef Zied El; Zouheir, Jerbi; Bagate, François; Bousselmi, Radhwen; Schortgen, Frédérique; Asfar, Pierre; Guérot, Emmanuel; Fabien, Grelon; Anguel, Nadia; Sigismond, Lasocki; Matthieu, Henry-Lagarrigue; Gonzalez, Frédéric; François, Legay; Guitton, Christophe; Schenck, Maleka; Jean-Marc, Doise; Dreyfuss, Didier; Radermacher, Peter; Frère, Antoine; Martin-Lefèvre, Laurent; Colin, Gwenhaël; Fiancette, Maud; Henry-Laguarrigue, Matthieu; Lacherade, Jean-Claude; Lebert, Christine; Vinatier, Isabelle; Yehia, Aihem; Joret, Aurélie; Menunier-Beillard, Nicolas; Benzekri-Lefevre, Dalila; Desachy, Arnaud; Bellec, Fréderic; Plantefève, Gaëtan; Quenot, Jean-Pierre; Meziani, Ferhat; Tavernier, Elsa; Ehrmann, Stephan; Chudeau, Nicolas; Raveau, Tommy; Moal, Valérie; Houillier, Pascal; Rouve, Emmanuelle; Lakhal, Karim; Gandonnière, Charlotte Salmon; Jouan, Youenn; Bodet-Contentin, Laetitia; Balmier, Adrien; Messika, Jonathan; De Montmollin, Etienne; Pouyet, Victorine; Sztrymf, Benjamin; Thiagarajah, Abirami; Roux, Damien; De Chambrun, Marc Pineton; Luyt, Charles-Edouard; Beloncle, François; Zapella, Nathalie; Ledochowsky, Stanislas; Terzi, Nicolas; Mazou, Jean-Marc; Sonneville, Romain; Paulus, Sylvie; Fedun, Yannick; Landais, Mickael; Raphalen, Jean-Herlé; Combes, Alain; Amoura, Zahir; Jacquemin, Aemilia; Guerrero, Felipe; Marcheix, Bertrand; Hernandez, Nicolas; Fourcade, Olivier; Georges, Bernard; Delmas, Clément; Makoudi, Sarah; Genton, Audrey; Bernard, Rémy; Lebreton, Guillaume; Amour, Julien; Mazet, Charlotte; Bounes, Fanny; Murat, Gurbuz; Cronier, Laure; Robin, Guillaume; Biendel, Caroline; Silva, Stein; Boubeche, Samia; Abriou, Caroline; Wurtz, Véronique; Scherrer, Vincent; Rey, Nathalie; Gastaldi, Gioia; Veber, Benoit; Doguet, Fabien; Gay, Arnaud; Dureuil, Bertrand; Besnier, Emmanuel; Rouget, Antoine; Gantois, Guillaume; Magalhaes, Eric; Wanono, Ruben; Smonig, Roland; Lermuzeaux, Mathilde; Lebut, Jordane; Olivier, Andremont; Dupuis, Claire; Radjou, Aguila; Mourvillier, Bruno; Neuville, Mathilde; D’ortho, Marie Pia; Bouadma, Lila; Rouvel-Tallec, Anny; Rudler, Marika; Weiss, Nicolas; Perlbarg, Vincent; Galanaud, Damien; Thabut, Dominique; Rachdi, Emna; Mhamdi, Ghada; Trifi, Ahlem; Abdelmalek, Rim; Abdellatif, Sami; Daly, Foued; Nasri, Rochdi; Tiouiri, Hanene; Lakhal, Salah Ben; Rousseau, Geoffroy; Asmolov, Romain; Grammatico-Guillon, Leslie; Auvet, Adrien; Laribi, Said; Garot, Denis; Dequin, Pierre François; Guillon, Antoine; Fergé, Jean-Louis; Abgrall, Gwénolé; Hinault, Ronan; Vally, Shazima; Roze, Benoit; Chaplain, Agathe; Chabartier, Cyrille; Savidan, Anne-Charlotte; Marie, Sabia; Cabie, Andre; Resiere, Dabor; Valentino, Ruddy; Mehdaoui, Hossein; Benarous, Lucas; Soda-Diop, Marième; Bouzana, Fouad; Perrin, Gilles; Bourenne, Jeremy; Eon, Béatrice; Lambert, Dominique; Trebuchon, Agnes; Poncelet, Géraldine; Le Bourgeois, Fleur; Michael, Levy; Camille, Guillot; Naudin, Jérôme; Deho, Anna; Dauger, Stéphane; Sauthier, Michaël; Bergeron-Gallant, Krystale; Emeriaud, Guillaume; Jouvet, Philippe; Tiebergien, Nicolas; Jacquet-Lagrèze, Matthias; Fellahi, Jean-Luc; Baudin, Florent; Essouri, Sandrine; Javouhey, Etienne; Guérin, Claude; Lampin, Marie; Mamouri, Ouardia; Devos, Patrick; Karaca-Altintas, Yasemin; Vinchon, Matthieu; Brossier, David; Eltaani, Redha; Teyssedre, Sonia; Sabine, Meyet; Bouchut, Jean-Christophe; Peguet, Olivier; Petitdemange, Lucie; Guilbert, Anne Sophie; Aoul, Nabil Tabet; Addou, Zakaria; Aouffen, Nabil; Anas, Benqqa; Kalouch, Samira; Yaqini, Khalid; Chlilek, Aziz; Abdou, Rchi; Gravellier, Perrine; Chantreuil, Julie; Travers, Nadine; Listrat, Antoine; Le Reun, Claire; Favrais, Geraldine; Coppere, Zoe; Blanot, Stéphane; Montmayeur, Juliette; Bronchard, Régis; Rolando, Stephane; Orliaguet, Gilles; Leger, Pierre-Louis; Rambaud, Jérôme; Thueux, Emilie; De Larrard, Alexandra; Berthelot, Véronique; Denot, Julien; Reymond, Marie; Amblard, Alain; Morin-Zorman, Sarah; Lengliné, Etienne; Pichereau, Claire; Mariotte, Eric; Emmanuel, Canet; Poujade, Julien; Trumpff, Guillaume; Janssen-Langenstein, Ralf; Harlay, Marie-Line; Zaid, Noorah; Ait-Ammar, Nawel; Bonnal, Christine; Merle, Jean-Claude; Botterel, Francoise; Levesque, Eric; Riad, Zakaria; Mezidi, Mehdi; Yonis, Hodane; Aublanc, Mylène; Perinel-Ragey, Sophie; Lissonde, Floriane; Louf-Durier, Aurore; Tapponnier, Romain; Louis, Bruno; Forel, Jean-Marie; Bisbal, Magali; Lehingue, Samuel; Rambaud, Romain; Adda, Mélanie; Hraiech, Sami; Marchi, Elisa; Roch, Antoine; Guerin, Vincent; Rozencwajg, Sacha; Schmidt, Matthieu; Hekimian, Guillaume; Bréchot, Nicolas; Trouillet, Jean Louis; Besset, Sébastien; Franchineau, Guillaume; Nieszkowska, Ania; Pascal, Leprince; Loiselle, Maud; Sarah, Chemam; Laurence, Dangers; Guillemette, Thomas; Jacquens, Alice; Kerever, Sebastien; Guidet, Bertrand; Aegerter, Philippe; Das, Vincent; Fartoukh, Muriel; Hayon, Jan; Desmard, Mathieu; Fulgencio, Jean-Pierre; Zuber, Benjamin; Soufi, A.; Khaleq, K.; Hamoudi, D.; Garret, Charlotte; Peron, Matthieu; Coron, Emmanuel; Bretonnière, Cédric; Audureau, Etienne; Audrey, Winters; Christophe, Duvoux; Christian, Jacquelinet; Daniel, Azoulay; Cyrille, Feray; Aissaoui, Wissal; Rghioui, Kawtar; Haddad, Wafae; Barrou, Houcine; Carteaux-Taeib, Anna; Lupinacci, Renato; Manceau, Gilles; Jeune, Florence; Tresallet, Christophe; Habacha, Sahar; Fathallah, Ines; Zoubli, Aymen; Aloui, Rafaa; Kouraichi, Nadia; Jouet, Emilie; Badin, Julie; Fermier, Brice; Feller, Marc; Serie, Mathieu; Pillot, Jérôme; Marie, William; Gisbert-Mora, Chloé; Vinclair, Camille; Lesbordes, Pierre; Mathieu, Pascal; De Brabant, Fabienne; Muller, Emmanuel; Robaux, Marie-Aline; Giabicani, Mikhael; Marchalot, Antoine; Gelinotte, Stéphanie; Declercq, Pierre Louis; Eraldi, Jean-Pierre; Bougerol, François; Meunier-Beillard, Nicolas; Devilliers, Hervé; Rigaud, Jean-Philippe; Verrière, Camille; Ardisson, Fanny; Kentish-Barnes, Nancy; Jacq, Gwenaëlle; Chermak, Akli; Lautrette, Alexandre; Legrand, Matthieu; Soummer, Alexis; Thiery, Guillaume; Cottereau, Alice; Canet, Emmanuel; Caujolle, Marie; Allyn, Jérôme; Valance, Dorothée; Brulliard, Caroline; Martinet, Olivier; Jabot, Julien; Gallas, Thomas; Vandroux, David; Allou, Nicolas; Durand, Arthur; Nevière, Rémi; Delguste, Florian; Boulanger, Eric; Preau, Sebastien; Martin, Ruste; Cochet, Hélène; Ponthus, Jean Pierre; Amilien, Virginie; Tchir, Martial; Barsam, Elise; Ayoub, Mohsen; Georger, Jean Francois; Guillame, Izaute; Assaraf, Julie; Tripon, Simona; Mallet, Maxime; Barbara, Guilaume; Louis, Guillaume; Gaudry, Stéphane; Barbarot, Nicolas; Jamet, Angéline; Outin, Hervé; Gibot, Sébastien; Bollaert, Pierre-Edouard; Holleville, Mathilde; Legriel, Stéphane; Chateauneuf, Anne Laure; Cavelot, Sébastien; Moyer, Jean-Denis; Bedos, Jean Pierre; Merle, Philippe; Laine, Aurelie; Natalie, De Sa; Cornuault, Mathieu; Libot, Jérome; Asehnoune, Karim; Rozec, Bertrand; Dantal, Jacques; Videcoq, Michel; Degroote, Thècle; Jaillette, Emmanuelle; Zerimech, Farid; Malika, Balduyck; Llitjos, Jean-François; Amara, Marlène; Lacave, Guillaume; Pangon, Béatrice; Mavinga, José; Makunza, Joseph Nsiala; Mafuta, M. E.; Yanga, Yves; Eric, Amisi; Ilunga, Jp; Kilembe, Ma; Alby-Laurent, Fanny; Toubiana, Julie; Mokline, Amel; Laajili, Achraf; Amri, Helmi; Rahmani, Imene; Mensi, Nidhal; Gharsallah, Lazheri; Tlaili, Sofiene; Gasri, Bahija; Hammouda, Rym; Messadi, Amen Allah; Allain, Pierre-Antoine; Gault, Nathallie; Paugam-Burtz, Catherine; Foucrier, Arnaud; Chatbri, Bassem; Bourbiaa, Yousra; Thabet, Lamia; Neuschwander, Arthur; Vincent, Looten; Beck, Jennifer; Vibol, Chhor; Amelie, Yavchitz; Resche-Rigon, Matthieu; Pirracchio, Jean MantzRomain; Bureau, Côme; Decavèle, Maxens; Campion, Sébastien; Ainsouya, Roukia; Niérat, Marie-Cécile; Prodanovic, Hélène; Raux, Mathieu; Similowski, Thomas; Dubé, Bruno-Pierre; Demiri, Suela; Dres, Martin; May, Faten; Quintard, Hervé; Kounis, Ilias; Saliba, Faouzi; André, Stephane; Boudon, Marc; Ichai, Philippe; Younes, Aline; Nakad, Lionel; Coilly, Audrey; Antonini, Teresa; Sobesky, Rodolphe; De Martin, Eleonora; Samuel, Didier; Hubert, Noemie; Nay, Mai-Anh; Auchabie, Johann; Giraudeau, Bruno; Jean, Reignier; Darmon, Michaël; Ruckly, Stephane; Garrouste-Orgeas, Maïté; Gratia, Elisabeth; Goldgran-Toledano, Dany; Jamali, Samir; Dumenil, Anne Sylvie; Schwebel, Carole; Brisard, Laurent; Bizouarn, Philippe; Lepoivre, Thierry; Nicolet, Johanna; Rigal, Jean Christophe; Roussel, Jean Christian; Cheurfa, Cherifa; Abily, Julien; Lescot, Thomas; Page, Isaline; Warnier, Stéphanie; Nys, Monique; Rousseau, Anne-Françoise; Damas, Pierre; Uhel, Fabrice; Lesouhaitier, Mathieu; Grégoire, Murielle; Gaudriot, Baptiste; Gacouin, Arnaud; Le Tulzo, Yves; Flecher, Erwan; Tarte, Karin; Tadié, Jean-Marc; Georges, Quentin; Soares, M.; Jeon, Kyeongman; Oeyen, Sandra; Rhee, Chin Kook; Gruber, Pascale; Ostermann, Marlies; Hill, Quentin; Depuydt, Peter; Ferra, Christelle; Muller, Alice; Aurelie, Bourmaud; Niles, Christopher; Herbert, Fabien; Pied, Sylviane; Loridant, Séverine; François, Nadine; Bignon, Anne; Sendid, Boualem; Lemaitre, Caroline; Dupre, Celine; Zayene, Aymen; Portier, Lucie; De Freitas Caires, Nathalie; Lassalle, Philippe; Le Neindre, Aymeric; Selot, Pascal; Ferreiro, Daniel; Bonarek, Maria; Henriot, Stépahen; Rodriguez, Julie; Taddei, Mara; Di Bari, Mauro; Hickmann, Cheryl; Castanares-Zapatero, Diego; Deldicque, Louise; Van Den Bergh, Peter; Caty, Gilles; Roeseler, Jean; Francaux, Marc; Laterre, Pierre-François; Dupuis, Bastien; Machayeckhi, Sharam; Sarfati, Celine; Moore, Alex; Mendialdua, Paula; Rodet, Emilie; Pilorge, Catherine; Stephan, Francois; Rezaiguia-Delclaux, Saida; Dugernier, Jonathan; Hesse, Michel; Jumetz, Thibaud; Bialais, Emilie; Depoortere, Virginie; Michotte, Jean Bernard; Wittebole, Xavier; Jamar, François title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 journal: Ann Intensive Care DOI: 10.1186/s13613-016-0224-7 sha: doc_id: 14538 cord_uid: 6a2pviol file: cache/cord-013380-1jwzbgwb.json key: cord-013380-1jwzbgwb authors: Parrilla, Claudio; Longobardi, Ylenia; Paludetti, Gaetano; Marenda, Maria Elisabetta; D’Alatri, Lucia; Bussu, Francesco; Scarano, Emanuele; Galli, Jacopo title: A one-year time frame for voice prosthesis management. What should the physician expect? Is it an overrated job? date: 2020-08-17 journal: Acta Otorhinolaryngol Ital DOI: 10.14639/0392-100x-n0587 sha: doc_id: 13380 cord_uid: 1jwzbgwb file: cache/cord-014712-5u4e00q6.json key: cord-014712-5u4e00q6 authors: nan title: Selected Abstracts from the 100th J Project Meeting, Antalya, Turkey, March 12-14, 2014 date: 2014-08-02 journal: J Clin Immunol DOI: 10.1007/s10875-014-0065-9 sha: doc_id: 14712 cord_uid: 5u4e00q6 file: cache/cord-013558-0sa63lp3.json key: cord-013558-0sa63lp3 authors: Farwana, Reem; Sheriff, Adam; Manzar, Haider; Farwana, Mohammad; Yusuf, Ammar; Sheriff, Ibrahim title: Watch this space: a systematic review of the use of video-based media as a patient education tool in ophthalmology date: 2020-03-09 journal: Eye (Lond) DOI: 10.1038/s41433-020-0798-z sha: doc_id: 13558 cord_uid: 0sa63lp3 file: cache/cord-015090-n6f4xupw.json key: cord-015090-n6f4xupw authors: nan title: PS 339-563 date: 2005-09-10 journal: Intensive Care Med DOI: 10.1007/s00134-005-2780-4 sha: doc_id: 15090 cord_uid: n6f4xupw file: cache/cord-014670-e31g8lns.json key: cord-014670-e31g8lns authors: nan title: Poster Sessions 313-503 date: 2004-10-05 journal: Intensive Care Med DOI: 10.1007/s00134-004-2406-2 sha: doc_id: 14670 cord_uid: e31g8lns file: cache/cord-014933-3jezc081.json key: cord-014933-3jezc081 authors: Özdemir, Seray Karagöz; Iltar, Utku; Salim, Ozan; Yücel, Orhan Kemal; Erdem, Ramazan; Turhan, Özge; Undar, Levent title: Investigation of seasonal frequency and pathogens in febrile neutropenia date: 2019-01-15 journal: Memo DOI: 10.1007/s12254-018-0468-z sha: doc_id: 14933 cord_uid: 3jezc081 file: cache/cord-015082-l629n8is.json key: cord-015082-l629n8is authors: nan title: Poster Sessions 323-461 date: 2002-08-29 journal: Intensive Care Med DOI: 10.1007/s00134-002-1455-7 sha: doc_id: 15082 cord_uid: l629n8is file: cache/cord-015335-l0kjxhd1.json key: cord-015335-l0kjxhd1 authors: nan title: Irish Society of Gastroenterology: Proceedings for summer meeting – 26th/27th May 1995 in Galway date: 1995 journal: Ir J Med Sci DOI: 10.1007/bf02967835 sha: doc_id: 15335 cord_uid: l0kjxhd1 file: cache/cord-014965-efmozngq.json key: cord-014965-efmozngq authors: nan title: Infectious diseases other than CMV (1st Section) date: 2001-06-11 journal: Bone Marrow Transplant DOI: 10.1038/sj.bmt.1702942 sha: doc_id: 14965 cord_uid: efmozngq file: cache/cord-015162-6be21d59.json key: cord-015162-6be21d59 authors: nan title: Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin date: 2016-05-04 journal: Med Klin Intensivmed Notfmed DOI: 10.1007/s00063-016-0166-8 sha: doc_id: 15162 cord_uid: 6be21d59 file: cache/cord-010980-sizuef1v.json key: cord-010980-sizuef1v authors: nan title: ECTES Abstracts 2020 date: 2020-05-11 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-020-01343-y sha: doc_id: 10980 cord_uid: sizuef1v file: cache/cord-014980-cz1gx9oj.json key: cord-014980-cz1gx9oj authors: Cheng, Qinglin; Sun, Zhou; Zhao, Gang; Xie, Li title: Nomogram for the Individualized Prediction of Survival Among Patients with H7N9 Infection date: 2020-03-20 journal: Risk Manag Healthc Policy DOI: 10.2147/rmhp.s242168 sha: doc_id: 14980 cord_uid: cz1gx9oj file: cache/cord-015389-vwgai4k9.json key: cord-015389-vwgai4k9 authors: nan title: Publication only date: 2009-03-25 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2009.50 sha: doc_id: 15389 cord_uid: vwgai4k9 file: cache/cord-014533-6qfecv5h.json key: cord-014533-6qfecv5h authors: Velasquez, T.; Mackey, G.; Lusk, J.; Kyle, U. G.; Fontenot, T.; Marshall, P.; Shekerdemian, L. S.; Coss-Bu, J. A.; Nishigaki, A.; Yatabe, T.; Tamura, T.; Yamashita, K.; Yokoyama, M.; Ruiz-Rodriguez, J. C.; Encina, B.; Belmonte, R.; Troncoso, I.; Tormos, P.; Riveiro, M.; Baena, J.; Sanchez, A.; Bañeras, J.; Cordón, J.; Duran, N.; Ruiz, A.; Caballero, J.; Nuvials, X.; Riera, J.; Serra, J.; Rutten, A. M. F.; van Ieperen, S. N. M.; Der Kinderen, E. P. H. M.; Van Logten, T.; Kovacikova, L.; Skrak, P.; Zahorec, M.; Kyle, U. G.; Akcan-Arikan, A.; Silva, J. C.; Mackey, G.; Lusk, J.; Goldsworthy, M.; Shekerdemian, L. S.; Coss-Bu, J. A.; Wood, D.; Harrison, D.; Parslow, R.; Davis, P.; Pappachan, J.; Goodwin, S.; Ramnarayan, P.; Chernyshuk, S.; Yemets, H.; Zhovnir, V.; Pulitano’, S. M.; De Rosa, S.; Mancino, A.; Villa, G.; Tosi, F.; Franchi, P.; Conti, G.; Patel, B.; Khine, H.; Shah, A.; Sung, D.; Singer, L.; Haghbin, S.; Inaloo, S.; Serati, Z.; Idei, M.; Nomura, T.; Yamamoto, N.; Sakai, Y.; Yoshida, T.; Matsuda, Y.; Yamaguchi, Y.; Takaki, S.; Yamaguchi, O.; Goto, T.; Longani, N.; Medar, S.; Abdel-Aal, I. R.; El Adawy, A. S.; Mohammed, H. M. E. H.; Mohamed, A. N.; Parry, S. M.; Knight, L. D.; Denehy, L.; De Morton, N.; Baldwin, C. E.; Sani, D.; Kayambu, G.; da Silva, V. Z. M.; Phongpagdi, P.; Puthucheary, Z. A.; Granger, C. L.; Rydingsward, J. E.; Horkan, C. M.; Christopher, K. B.; McWilliams, D.; Jones, C.; Reeves, E.; Atkins, G.; Snelson, C.; Aitken, L. M.; Rattray, J.; Kenardy, J.; Hull, A. M.; Ullman, A.; Le Brocque, R.; Mitchell, M.; Davis, C.; Macfarlane, B.; Azevedo, J. C.; Rocha, L. L.; De Freitas, F. F. M.; Cavalheiro, A. M.; Lucinio, N. M.; Lobato, M. S.; Ebeling, G.; Kraegpoeth, A.; Laerkner, E.; De Brito-Ashurst, I.; White, C.; Gregory, S.; Forni, L. G.; Flowers, E.; Curtis, A.; Wood, C. A.; Siu, K.; Venkatesan, K.; Muhammad, J. B. H.; Ng, L.; Seet, E.; Baptista, N.; Escoval, A.; Tomas, E.; Agrawal, R.; Mathew, R.; Varma, A.; Dima, E.; Charitidou, E.; Perivolioti, E.; Pratikaki, M.; Vrettou, C.; Giannopoulos, A.; Zakynthinos, S.; Routsi, C.; Atchade, E.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Genève, C.; Tanaka, S.; Lortat-Jacob, B.; Augustin, P.; Desmard, M.; Montravers, P.; de Molina, F. J. González; Barbadillo, S.; Alejandro, R.; Álvarez-Lerma, F.; Vallés, J.; Catalán, R. M.; Palencia, E.; Jareño, A.; Granada, R. M.; Ignacio, M. L.; Cui, N.; Liu, D.; Wang, H.; Su, L.; Qiu, H.; Li, R.; Jaffal, K.; Rouzé, A.; Poissy, J.; Sendid, B.; Nseir, S.; Paramythiotou, E.; Rizos, M.; Frantzeskaki, F.; Antoniadou, A.; Vourli, S.; Zerva, L.; Armaganidis, A.; Riera, J.; Gottlieb, J.; Greer, M.; Wiesner, O.; Martínez, M.; Acuña, M.; Rello, J.; Welte, T.; Atchade, E.; Mignot, T.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Lortat-Jacob, B.; Tanaka, S.; Augustin, P.; Desmard, M.; Montravers, P.; Soussi, S.; Dudoignon, E.; Ferry, A.; Chaussard, M.; Benyamina, M.; Alanio, A.; Touratier, S.; Chaouat, M.; Lafaurie, M.; Mimoun, M.; Mebazaa, A.; Legrand, M.; Sheils, M. A.; Patel, C.; Mohankumar, L.; Akhtar, N.; Noriega, S. K. Pacheco; Aldana, N. Navarrete; León, J. L. Ávila; Baquero, J. Durand; Bernal, F. Fernández; Ahmadnia, E.; Hadley, J. S.; Millar, M.; Hall, D.; Hewitt, H.; Yasuda, H.; Sanui, M.; Komuro, T.; Kawano, S.; Andoh, K.; Yamamoto, H.; Noda, E.; Hatakeyama, J.; Saitou, N.; Okamoto, H.; Kobayashi, A.; Takei, T.; Matsukubo, S.; Rotzel, H. B.; Lázaro, A. Serrano; Prada, D. Aguillón; Gimillo, M. Rodriguez; Barinas, O. Diaz; Cortes, M. L. Blasco; Franco, J. Ferreres; Roca, J. M. Segura; Carratalá, A.; Gonçalves, B.; Turon, R.; Mendes, A.; Miranda, F.; Mata, P. J.; Cavalcanti, D.; Melo, N.; Lacerda, P.; Kurtz, P.; Righy, C.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Romero, J. C. García; Herrera, A. N. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Hualde, J. Barado; Hernández, A. Ansotegui; Irazabal, J. M. Guergué; Spatenkova, V.; Bradac, O.; Suchomel, P.; Urli, T.; Lazzeri, E. Heusch; Aspide, R.; Zanello, M.; Perez-Borrero, L.; Garcia-Alvarez, J. M.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Rivera-Fernandez, R.; Mora-Ordoñez, J.; De La Fuente-Martos, C.; Castillo-Lorente, E.; Guerrero-Lopez, F.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Pertuz, E. D. Díaz; Hernández, A. Ansotegui; Romero, J. C. García; Sánchez, M. J. Gómez; Herrera, A. N. García; Ramírez, J. Roldán; Sanz, E. Regidor; Hualde, J. Barado; León, J. P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. L.; Pérez, H.; Calpe, P.; Alcala, M. A.; Robaglia, D.; Perez, C.; Lan, S. K.; Cunha, M. M.; Moreira, T.; Santos, F.; Lafuente, E.; Fernandes, M. J.; Silva, J. G.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Herrera, A. N. García; Romero, J. C. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Echeverría, J. G. Armando; Hernández, A. Ansotegui; Hualde, J. Barado; Podlepich, V.; Sokolova, E.; Alexandrova, E.; Lapteva, K.; Kurtz, P.; Shuinotsuka, C.; Rabello, L.; Vianna, G.; Reis, A.; Cairus, C.; Salluh, J.; Bozza, F.; Torres, J. C. Barrios; Araujo, N. J. Fernández; García-Olivares, P.; Keough, E.; Dalorzo, M.; Tang, L. K.; De Sousa, I.; Díaz, M.; Marcos-Zambrano, L. J.; Guerrero, J. E.; Gomez, S. E. Zamora; Lopez, G. D. Hernandez; Cuellar, A. I. Vazquez; Nieto, O. R. Perez; Gonzalez, J. A. Castanon; Bhasin, D.; Rai, S.; Singh, H.; Gupta, O.; Bhattal, M. K.; Sampley, S.; Sekhri, K.; Nandha, R.; Aliaga, F. A.; Olivares, F.; Appiani, F.; Farias, P.; Alberto, F.; Hernández, A.; Pons, S.; Sonneville, R.; Bouadma, L.; Neuville, M.; Mariotte, E.; Radjou, A.; Lebut, J.; Chemam, S.; Voiriot, G.; Dilly, M. P.; Mourvillier, B.; Dorent, R.; Nataf, P.; Wolff, M.; Timsit, J. F.; Ediboglu, O.; Ataman, S.; Ozkarakas, H.; Kirakli, C.; Vakalos, A.; Avramidis, V.; Obukhova, O.; Kurmukov, I. A.; Kashiya, S.; Golovnya, E.; Baikova, V. N.; Ageeva, T.; Haritydi, T.; Kulaga, E. V.; Rios-Toro, J. J.; Perez-Borrero, L.; Aguilar-Alonso, E.; Arias-Verdu, M. D.; Garcia-Alvarez, J. M.; Lopez-Caler, C.; De La Fuente-Martos, C.; Rodriguez-Fernandez, S.; Sanchez-Orézzoli, M. Gomez; Martin-Gallardo, F.; Nikhilesh, J.; Joshi, V.; Villarreal, E.; Ruiz, J.; Gordon, M.; Quinza, A.; Gimenez, J.; Piñol, M.; Castellanos, A.; Ramirez, P.; Jeon, Y. D.; Jeong, W. Y.; Kim, M. H.; Jeong, I. Y.; Ahn, M. Y.; Ahn, J. Y.; Han, S. H.; Choi, J. Y.; Song, Y. G.; Kim, J. M.; Ku, N. S.; Shah, H.; Kellner, F.; Rezai, F.; Mistry, N.; Yodice, P.; Ovnanian, V.; Fless, K.; Handler, E.; Alejos, R. Martínez; Romeu, J. D. Martí; Antón, D. González; Quinart, A.; Martí, A. Torres; Llaurado-Serra, M.; Lobo-Civico, A.; Ventura-Rosado, A.; Piñol-Tena, A.; Pi-Guerrero, M.; Paños-Espinosa, C.; Peralvo-Bernat, M.; Marine-Vidal, J.; Gonzalez-Engroba, R.; Montesinos-Cerro, N.; Treso-Geira, M.; Valeiras-Valero, A.; Martinez-Reyes, L.; Sandiumenge, A.; Jimenez-Herrera, M. F.; Helyar, S.; Riozzi, P.; Noon, A.; Hallows, G.; Cotton, H.; Keep, J.; Hopkins, P. A.; Taggu, A.; Renuka, S.; Sampath, S.; Rood, P. J. T.; Frenzel, T.; Verhage, R.; Bonn, M.; Pickkers, P.; van der Hoeven, J. G.; van den Boogaard, M.; Corradi, F.; Melnyk, L.; Moggia, F.; Pienovi, R.; Adriano, G.; Brusasco, C.; Mariotti, L.; Lattuada, M.; Bloomer, M. J.; Coombs, M.; Ranse, K.; Endacott, R.; Maertens, B.; Blot, K.; Blot, S.; Amerongen, M. P. van Nieuw; van der Heiden, E. S.; Twisk, J. W. R.; Girbes, A. R. J.; Spijkstra, J. J.; Riozzi, P.; Helyar, S.; Cotton, H.; Hallows, G.; Noon, A.; Bell, C.; Peters, K.; Feehan, A.; Keep, J.; Hopkins, P. A.; Churchill, K.; Hawkins, K.; Brook, R.; Paver, N.; Endacott, R.; Maistry, N.; van Wijk, A.; Rouw, N.; van Galen, T.; Evelein-Brugman, S.; Taggu, A.; Krishna, B.; Sampath, S.; Putzu, A.; Fang, M.; Berto, M. Boscolo; Belletti, A.; Cassina, T.; Cabrini, L.; Mistry, M.; Alhamdi, Y.; Welters, I.; Abrams, S. T.; Toh, C. H.; Han, H. S.; Gil, E. M.; Lee, D. S.; Park, C. M.; Winder-Rhodes, S.; Lotay, R.; Doyle, J.; Ke, M. W.; Huang, W. C.; Chiang, C. H.; Hung, W. T.; Cheng, C. C.; Lin, K. C.; Lin, S. C.; Chiou, K. R.; Wann, S. R.; Shu, C. W.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Dubó, S.; Aquevedo, A.; Jibaja, M.; Berrutti, D.; Labra, C.; Lagos, R.; García, M. F.; Ramirez, V.; Tobar, M.; Picoita, F.; Peláez, C.; Carpio, D.; Alegría, L.; Hidalgo, C.; Godoy, K.; Bakker, J.; Hernández, G.; Sadamoto, Y.; Katabami, K.; Wada, T.; Ono, Y.; Maekawa, K.; Hayakawa, M.; Sawamura, A.; Gando, S.; Marin-Mateos, H.; Perez-Vela, J. L.; Garcia-Gigorro, R.; Peiretti, M. A. Corres; Lopez-Gude, M. J.; Chacon-Alves, S.; Renes-Carreño, E.; Montejo-González, J. C.; Parlevliet, K. L.; Touw, H. R. W.; Beerepoot, M.; Boer, C.; Elbers, P. W. G.; Tuinman, P. R.; Abdelmonem, S. A.; Helmy, T. A.; El Sayed, I.; Ghazal, S.; Akhlagh, S. H.; Masjedi, M.; Hozhabri, K.; Kamali, E.; Zýková, I.; Paldusová, B.; Sedlák, P.; Morman, D.; Youn, A. M.; Ohta, Y.; Sakuma, M.; Bates, D.; Morimoto, T.; Su, P. L.; Chang, W. Y.; Lin, W. C.; Chen, C. W.; Facchin, F.; Zarantonello, F.; Panciera, G.; De Cassai, A.; Venrdramin, A.; Ballin, A.; Tonetti, T.; Persona, P.; Ori, C.; Del Sorbo, L.; Rossi, S.; Vergani, G.; Cressoni, M.; Chiumello, D.; Chiurazzi, C.; Brioni, M.; Algieri, I.; Tonetti, T.; Guanziroli, M.; Colombo, A.; Tomic, I.; Colombo, A.; Crimella, F.; Carlesso, E.; Gasparovic, V.; Gattinoni, L.; Neto, A. Serpa; Schmidt, M.; Pham, T.; Combes, A.; de Abreu, M. Gama; Pelosi, P.; Schultz, M. J.; Katira, B. H.; Engelberts, D.; Giesinger, R. E.; Ackerley, C.; Yoshida, T.; Zabini, D.; Otulakowski, G.; Post, M.; Kuebler, W. M.; McNamara, P. J.; Kavanagh, B. P.; Pirracchio, R.; Rigon, M. Resche; Carone, M.; Chevret, S.; Annane, D.; Eladawy, S.; El-Hamamsy, M.; Bazan, N.; Elgendy, M.; De Pascale, G.; Vallecoccia, M. S.; Cutuli, S. L.; Di Gravio, V.; Pennisi, M. A.; Conti, G.; Antonelli, M.; Andreis, D. T.; Khaliq, W.; Singer, M.; Hartmann, J.; Harm, S.; Carmona, S. Alcantara; Almudevar, P. Matia; Abellán, A. Naharro; Ramos, J. Veganzones; Pérez, L. Pérez; Valbuena, B. Lobo; Sanz, N. Martínez; Simón, I. Fernández; Arrigo, M.; Feliot, E.; Deye, N.; Cariou, A.; Guidet, B.; Jaber, S.; Leone, M.; Resche-Rigon, M.; Baron, A. Vieillard; Legrand, M.; Gayat, E.; Mebazaa, A.; Balik, M.; Kolnikova, I.; Maly, M.; Waldauf, P.; Tavazzi, G.; Kristof, J.; Herpain, A.; Su, F.; Post, E.; Taccone, F.; Vincent, J. L.; Creteur, J.; Lee, C.; Hatib, F.; Jian, Z.; Buddi, S.; Cannesson, M.; Fileković, S.; Turel, M.; Knafelj, R.; Gorjup, V.; Stanić, R.; Gradišek, P.; Cerović, O.; Mirković, T.; Noč, M.; Tirkkonen, J.; Hellevuo, H.; Olkkola, K. T.; Hoppu, S.; Lin, K. C.; Hung, W. T.; Chiang, C. C.; Huang, W. C.; Juan, W. C.; Lin, S. C.; Cheng, C. C.; Lin, P. H.; Fong, K. Y.; Hou, D. S.; Kang, P. L.; Wann, S. R.; Chen, Y. S.; Mar, G. Y.; Liu, C. P.; Paul, M.; Bougouin, W.; Geri, G.; Dumas, F.; Champigneulle, B.; Legriel, S.; Charpentier, J.; Mira, J. P.; Sandroni, C.; Cariou, A.; Zimmerman, J.; Sullivan, E.; Noursadeghi, M.; Fox, B.; Sampson, D.; McHugh, L.; Yager, T.; Cermelli, S.; Seldon, T.; Bhide, S.; Brandon, R. A.; Brandon, R. B.; Zwaag, J.; Beunders, R.; Pickkers, P.; Kox, M.; Gul, F.; Arslantas, M. K.; Genc, D.; Zibandah, N.; Topcu, L.; Akkoc, T.; Cinel, I.; Greco, E.; Lauretta, M. P.; Andreis, D. T.; Singer, M.; Garcia, I. Palacios; Cordero, M.; Martin, A. Diaz; Pallás, T. Aldabó; Montero, J. Garnacho; Rey, J. Revuelto; Malo, L. Roman; Montoya, A. A. Tanaka; Martinez, A. D. C. Amador; Ayala, L. Y. Delgado; Zepeda, E. Monares; Granillo, J. Franco; Sanchez, J. Aguirre; Alejo, G. Camarena; Cabrera, A. Rugerio; Montenegro, A. Pedraza; Pham, T.; Beduneau, G.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Soilemezi, E.; Koco, E.; Savvidou, S.; Nouris, C.; Matamis, D.; Di Mussi, R.; Spadaro, S.; Volta, C. A.; Mariani, M.; Colaprico, A.; Antonio, C.; Bruno, F.; Grasso, S.; Rodriguez, A.; Martín-Loeches, I.; Díaz, E.; Masclans, J. R.; Gordo, F.; Solé-Violán, J.; Bodí, M.; Avilés-Jurado, F. X.; Trefler, S.; Magret, M.; Reyes, L. F.; Marín-Corral, J.; Yebenes, J. C.; Esteban, A.; Anzueto, A.; Aliberti, S.; Restrepo, M. I.; Larsson, J. Skytte; Redfors, B.; Ricksten, S. E.; Haines, R.; Powell-Tuck, J.; Leonard, H.; Ostermann, M.; Berthelsen, R. E.; Itenov, T. S.; Perner, A.; Jensen, J. U.; Ibsen, M.; Jensen, A. E. K.; Bestle, M. H.; Bucknall, T.; Dixon, J.; Boa, F.; MacPhee, I.; Philips, B. J.; Doyle, J.; Saadat, F.; Samuels, T.; Huddart, S.; McCormick, B.; DeBrunnar, R.; Preece, J.; Swart, M.; Peden, C.; Richardson, S.; Forni, L.; Kalfon, P.; Baumstarck, K.; Estagnasie, P.; Geantot, M. A.; Berric, A.; Simon, G.; Floccard, B.; Signouret, T.; Boucekine, M.; Fromentin, M.; Nyunga, M.; Sossou, A.; Venot, M.; Robert, R.; Follin, A.; Renault, A.; Garrouste, M.; Collange, O.; Levrat, Q.; Villard, I.; Thévenin, D.; Pottecher, J.; Patrigeon, R. G.; Revel, N.; Vigne, C.; Mimoz, O.; Auquier, P.; Pawar, S.; Jacques, T.; Deshpande, K.; Pusapati, R.; Wood, B.; Pulham, R. A.; Wray, J.; Brown, K.; Pierce, C.; Nadel, S.; Ramnarayan, P.; Azevedo, J. R.; Montenegro, W. S.; Rodrigues, D. P.; Sousa, S. C.; Araujo, V. F.; Leitao, A. L.; Prazeres, P. H.; Mendonca, A. V.; Paula, M. P.; Das Neves, A.; Loudet, C. I.; Busico, M.; Vazquez, D.; Villalba, D.; Lischinsky, A.; Veronesi, M.; Emmerich, M.; Descotte, E.; Juliarena, A.; Bisso, M. Carboni; Grando, M.; Tapia, A.; Camargo, M.; Ulla, D. Villani; Corzo, L.; dos Santos, H. Placido; Ramos, A.; Doglia, J. A.; Estenssoro, E.; Carbonara, M.; Magnoni, S.; Donald, C. L. Mac; Shimony, J. S.; Conte, V.; Triulzi, F.; Stretti, F.; Macrì, M.; Snyder, A. Z.; Stocchetti, N.; Brody, D. L.; Podlepich, V.; Shimanskiy, V.; Savin, I.; Lapteva, K.; Chumaev, A.; Tjepkema-Cloostermans, M. C.; Hofmeijer, J.; Beishuizen, A.; Hom, H.; Blans, M. J.; van Putten, M. J. A. M.; Longhi, L.; Frigeni, B.; Curinga, M.; Mingone, D.; Beretta, S.; Patruno, A.; Gandini, L.; Vargiolu, A.; Ferri, F.; Ceriani, R.; Rottoli, M. R.; Lorini, L.; Citerio, G.; Pifferi, S.; Battistini, M.; Cordolcini, V.; Agarossi, A.; Di Rosso, R.; Ortolano, F.; Stocchetti, N.; Lourido, C. Mora; Cabrera, J. L. Santana; Santana, J. D. Martín; Alzola, L. Melián; del Rosario, C. García; Pérez, H. Rodríguez; Torrent, R. Lorenzo; Eslami, S.; Dalhuisen, A.; Fiks, T.; Schultz, M. J.; Hanna, A. Abu; Spronk, P. E.; Wood, M.; Maslove, D.; Muscedere, J.; Scott, S. H.; Saha, T.; Hamilton, A.; Petsikas, D.; Payne, D.; Boyd, J. G.; Puthucheary, Z. A.; McNelly, A. S.; Rawal, J.; Connolly, B.; McPhail, M. J.; Sidhu, P.; Rowlerson, A.; Moxham, J.; Harridge, S. D.; Hart, N.; Montgomery, H. E.; Jovaisa, T.; Thomas, B.; Gupta, D.; Wijayatilake, D. S.; Shum, H. P.; King, H. S.; Chan, K. C.; Tang, K. B.; Yan, W. W.; Arias, C. Castro; Latorre, J.; De La Rica, A. Suárez; Garrido, E. Maseda; Feijoo, A. Montero; Gancedo, C. Hernández; Tofiño, A. López; Rodríguez, F. Gilsanz; Gemmell, L. K.; Campbell, R.; Doherty, P.; MacKay, A.; Singh, N.; Vitaller, S.; Nagib, H.; Prieto, J.; Del Arco, A.; Zayas, B.; Gomez, C.; Tirumala, S.; Pasha, S. A.; Kumari, B. K.; Martinez-Lopez, P.; Puerto-Morlán, A.; Nuevo-Ortega, P.; Pujol, L. Martinez; Dolset, R. Algarte; González, B. Sánchez; Riera, S. Quintana; Álvarez, J. Trenado; Quintana, S.; Martínez, L.; Algarte, R.; Sánchez, B.; Trenado, J.; Tomas, E.; Brock, N.; Viegas, E.; Filipe, E.; Cottle, D.; Traynor, T.; Martínez, M. V. Trasmonte; Márquez, M. Pérez; Gómez, L. Colino; Martínez, N. Arias; Muñoz, J. M. Milicua; Bellver, B. Quesada; Varea, M. Muñoz; Llorente, M. Á. Alcalá; Calvo, C. Pérez; Hillier, S. D.; Faulds, M. C.; Hendra, H.; Lawrence, N.; Maekawa, K.; Hayakawa, M.; Ono, Y.; Kodate, A.; Sadamoto, Y.; Tominaga, N.; Mizugaki, A.; Murakami, H.; Yoshida, T.; Katabami, K.; Wada, T.; Sawamura, A.; Gando, S.; Silva, S.; Kerhuel, L.; Malagurski, B.; Citerio, G.; Chabanne, R.; Laureys, S.; Puybasset, L.; Nobile, L.; Pognuz, E. R.; Rossetti, A. O.; Verginella, F.; Gaspard, N.; Creteur, J.; Ben-Hamouda, N.; Oddo, M.; Taccone, F. S.; Ono, Y.; Hayakawa, M.; Iijima, H.; Maekawa, K.; Kodate, A.; Sadamoto, Y.; Mizugaki, A.; Murakami, H.; Katabami, K.; Wada, T.; Sawamura, A.; Gando, S.; Kodate, A.; Katabami, K.; Wada, T.; Ono, Y.; Maekawa, K.; Hayakawa, M.; Sawamura, A.; Gando, S.; Andersen, L. W.; Raymond, T.; Berg, R.; Nadkarni, V.; Grossestreuer, A.; Kurth, T.; Donnino, M.; Krüger, A.; Ostadal, P.; Janotka, M.; Vondrakova, D.; Kongpolprom, N.; Cholkraisuwat, J.; Pekkarinen, P. T.; Ristagno, G.; Masson, S.; Latini, R.; Bendel, S.; Ala-Kokko, T.; Varpula, T.; Vaahersalo, J.; Hoppu, S.; Tiainen, M.; Mion, M. M.; Plebani, M.; Pettilä, V.; Skrifvars, M.B.; Son, Y.; Kim, K. S.; Suh, G. J.; Kwon, W. Y.; Ko, J. I.; Park, M. J.; Cavicchi, F. Zama; Iesu, E.; Nobile, L.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Tanaka, H.; Otani, N.; Ode, S.; Ishimatsu, S.; Martínez, L.; Algarte, R.; Sánchez, B.; Romero, I.; Martínez, F.; Quintana, S.; Trenado, J.; Vondrakova, D.; Ostadal, P.; Kruger, A.; Janotka, M.; Malek, F.; Neuzil, P.; Yeh, Y. C.; Chen, Y. S.; Wang, C. H.; Huang, C. H.; Chao, A.; Lee, C. T.; Lai, C. H.; Chan, W. S.; Cheng, Y. J.; Sun, W. Z.; Kaese, S.; Horstmann, C.; Lebiedz, P.; Mourad, M.; Gaudard, P.; Eliet, J.; Zeroual, N.; Colson, P.; Ostadal, P.; Mlcek, M.; Hrachovina, M.; Kruger, A.; Vondrakova, D.; Janotka, M.; Mates, M.; Hala, P.; Kittnar, O.; Neuzil, P.; Jacky, A.; Rudiger, A.; Spahn, D. R.; Bettex, D. A.; Kara, A.; Akin, S.; Dos reis Miranda, D.; Struijs, A.; Caliskan, K.; van Thiel, R. J.; Dubois, E. A.; de Wilde, W.; Zijlstra, F.; Gommers, D.; Ince, C.; Marca, L.; Xini, A.; Mongkolpun, W.; Cordeiro, C. P. R.; Leite, R. T.; Lheureux, O.; Bader, A.; Rincon, L.; Santacruz, C.; Preiser, J. C.; Chao, A.; Chao, A. S.; Chen, Y. S.; Kim, W.; Ahn, C.; Cho, Y.; Lim, T. H.; Oh, J.; Choi, K. S.; Jang, B. H.; Ha, J. K.; Mecklenburg, A.; Stamm, J.; Soeffker, G.; Kubik, M.; Sydow, K.; Reichenspurner, H.; Kluge, S.; Braune, S.; Bergantino, B.; Ruberto, F.; Magnanimi, E.; Privato, E.; Zullino, V.; Bruno, K.; Pugliese, F.; Sales, G.; Girotto, V.; Vittone, F.; Brazzi, L.; Fritz, C.; Kimmoun, A.; Vanhuyse, F.; Trifan, B.; Orlowski, S.; Albuisson, E.; Tran, N.; Levy, B.; Chhor, V.; Joachim, J.; Follin, A.; Champigneulle, B.; Chatelon, J.; Fave, G.; Mantz, J.; Pirracchio, R.; Diaz, D. Díaz; Villanova, M.; Aguirregabyria, M.; Andrade, G.; López, L.; Palencia, E.; John, G.; Cowan, R.; Hart, R.; Lake, K.; Litchfield, K.; Song, J. W.; Lee, Y. J.; Cho, Y. J.; Choi, S.; Vermeir, P.; Vandijck, D.; Blot, S.; Mariman, A.; Verhaeghe, R.; Deveugele, M.; Vogelaers, D.; Chok, L.; Bachli, E. B.; Bettex, D.; Cottini, S. R.; Keller, E.; Maggiorini, M.; Schuepbach, R.; Fiks, T.; Stiphout, C.; Grevelink, M.; Vaneker, I.; Ruijter, A.; Buise, M.; Spronk, P. E.; Tena, S. Altaba; Barrachina, L. Galarza; Portillo, J. H. Rodriguez; Aznar, G. Pagés; Campos, L. Mateu; Sellés, M. D. Ferrándiz; Tomás, M. Arlandis; Muncharaz, A. Belenguer; Skinner, L.; Monsalvo, S.; Olavarria, E.; Stümpfle, R.; Na, S. J.; Park, J.; Chung, C. R.; Park, C. M.; Suh, G. Y.; Yang, J. H.; Witter, T.; Brousseau, C.; Butler, M. B.; Erdogan, M.; Dougall, P. C. Mac; Green, R. S.; Abbott, T. E. F.; Torrance, H. D. T.; Cron, N.; Vaid, N.; Emmanuel, J.; Siddiqui, S. S.; Prabu, N.; Chaudhari, H. K.; Patil, V. P.; Divatia, J. V.; Solanki, S.; Kulkarni, A. P.; Gutierrez, L. A. Rincon; Bader, A.; Brasseur, A.; Lheureux, O.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Hempel, D.; Stauffert, N.; Recker, F.; Schröder, T.; Reusch, S.; Schleifer, J.; Breitkreutz, R.; Sjövall, F.; Perner, A.; Møller, M. Hylander; Moraes, R. B.; Borges, F. K.; Guillen, J. A. V.; Zabaletta, W. J. C.; Ruiz-Ramos, J.; Ramirez, P.; Marqués-Miñana, M. R.; Villarreal, E.; Gordon, M.; Sosa, M.; Concha, P.; Castellanos, A.; Menendez, R.; Ramírez, C. Sánchez; Santana, M. Cabrera; Balcázar, L. Caipe; Escalada, S. Hípola; Viera, M. A. Hernández; Vázquez, C. F. Lübbe; Díaz, J. J. Díaz; Campelo, F. Artiles; Monroy, N. Sangil; Santana, P. Saavedra; Santana, S. Ruiz; Gutiérrez-Pizarraya, A.; Garnacho-Montero, J.; Martin, C.; Baumstarck, K.; Leone, M.; Martín-Loeches, I.; Pirracchio, R.; Legrand, M.; Mainardi, J. L.; Mantz, J.; Cholley, B.; Hubbard, A.; Frontera, P. Ruiz; Vega, L. M. Claraco; Miguelena, P. Ruiz de Gopegui; Usón, M. C. Villuendas; López, A. Rezusta; Clemente, E. Aurensanz; Ibañes, P. Gutiérrez; Aguilar, A. L. Ruiz; Palomar, M.; Olaechea, P.; Uriona, S.; Vallverdu, M.; Catalan, M.; Nuvials, X.; Aragon, C.; Lerma, F. Alvarez; Jeon, Y. D.; Jeong, W. Y.; Kim, M. H.; Jeong, I. Y.; Ahn, M. Y.; Ahn, J. Y.; Han, S. H.; Choi, J. Y.; Song, Y. G.; Kim, J. M.; Ku, N. S.; Bassi, G. Li; Xiol, E. Aguilera; Senussi, T.; Idone, F. A.; Motos, A.; Chiurazzi, C.; Travierso, C.; Fernández-Barat, L.; Amaro, R.; Hua, Y.; Ranzani, O. T.; Bobi, Q.; Rigol, M.; Torres, A.; Fernández, I. Fuentes; Soler, E. Andreu; de Vera, A. Pareja Rodríguez; Pastor, E. Escudero; Hernandis, V.; Ros Martínez, J.; Rubio, R. Jara; Torner, M. Miralbés; Brugger, S. Carvalho; Eroles, A. Aragones; Moles, S. Iglesias; Cabello, J. Trujillano; Schoenenberger, J. A.; Casals, X. Nuvials; Vidal, M. Vallverdu; Garrido, B. Balsera; Martinez, M. Palomar; Mirabella, L.; Cotoia, A.; Tullo, L.; Stella, A.; Di Bello, F.; Di Gregorio, A.; Dambrosio, M.; Cinnella, G.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Romero, J. C. García; Herrera, A. N. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Hualde, J. Barado; Hernández, A. Ansotegui; Ramirez, J. Roldán; Takahashi, H.; Kazutoshi, F.; Okada, Y.; Oobayashi, W.; Naito, T.; Baidya, D. K.; Maitra, S.; Anand, R. K.; Ray, B. R.; Arora, M. K.; Ruffini, C.; Rota, L.; Corona, A.; Sesana, G.; Ravasi, S.; Catena, E.; Naumann, D. N.; Mellis, C.; Husheer, S. L.; Bishop, J.; Midwinter, M. J.; Hutchings, S.; Corradi, F.; Brusasco, C.; Manca, T.; Ramelli, A.; Lattuada, M.; Nicolini, F.; Gherli, T.; Vezzani, A.; Young, A.; Carmona, A. Fernández; Santiago, A. Iglesias; Guillamon, L. Navarro; Delgado, M. J. García; Delgado-Amaya, M.; Curiel-Balsera, E.; Rivera-Romero, L.; Castillo-Lorente, E.; Carrero-Gómez, F.; Aguayo-DeHoyos, E.; Healey, A. J.; Cameron, C.; Jiao, L.R.; Stümpfle, R.; Pérez, A.; Martin, S.; del Moral, O. Lopez; Toval, S.; Rico, J.; Aldecoa, C.; Oguzhan, K.; Demirkiran, O.; Kirman, M.; Bozbay, S.; Kosuk, M. E.; Asyralyyeva, G.; Dilek, M.; Duzgun, M.; Telli, S.; Aydin, M.; Yilmazer, F.; Hodgson, L. E.; Dimitrov, B. D.; Stubbs, C.; Forni, L. G.; Venn, R.; Vedage, D.; Shawaf, S.; Naran, P.; Sirisena, N.; Kinnear, J.; Dimitrov, B. D.; Hodgson, L. E.; Stubbs, C.; Forni, L. G.; Venn, R.; Londoño, J. Gonzalez; Cardenas, C. Lorencio; Ginés, A. Sánchez; Gubianas, C. Murcia; Sánchez, E. Clapes; Sirvent, J. M.; Panafidina, V.; Shlyk, I.; Ilyina, V.; Judickas, S.; Kezyte, G.; Urbanaviciute, I.; Serpytis, M.; Gaizauskas, E.; Sipylaite, J.; Sprung, C. L.; Munteanu, G.; Morales, R. C.; Kasdan, H.; Volker, T.; Reiter, A.; Cohen, Y.; Himmel, Y.; Meissonnier, J.; Banderas-Bravo, M. E.; Gómez-Jiménez, C.; García-Martínez, M. V.; Martínez-Carmona, J. F.; Fernández-Ortega, J. F.; O‘Dwyer, M. J.; Starczewska, M.; Wilks, M.; Vincent, J. L.; Torsvik, M.; Gustad, L. T.; Bangstad, I. L.; Vinje, L. J.; Damås, J. K.; Solligård, E.; Mehl, A.; Tsunoda, M.; Kang, M.; Saito, M.; Saito, N.; Akizuki, N.; Namiki, M.; Takeda, M.; Yuzawa, J.; Yaguchi, A.; Frantzeskaki, F.; Tsirigotis, P.; Chondropoulos, S.; Paramythiotou, E.; Theodorakopoulou, M.; Stamouli, M.; Gkirkas, K.; Dimopoulou, I. K.; Makiko, S.; Tsunoda, M.; Kang, M.; Yuzawa, J.; Akiduki, N.; Namiki, M.; Takeda, M.; Yaguchi, A.; Preau, S.; Ambler, M.; Sigurta, A.; Saeed, S.; Singer, M.; Jochmans, S.; Chelly, J.; Vong, L. V. P.; Sy, O.; Serbource-Goguel, J.; Rolin, N.; Weyer, C. M.; Abdallah, R. I.; Adrie, C.; Vinsonneau, C.; Monchi, M.; Mayr, U.; Huber, W.; Karsten, E.; Lahmer, T.; Thies, P.; Henschel, B.; Fischer, G.; Schmid, R. M.; Ediboglu, O.; Ataman, S.; Naz, I.; Yaman, G.; Kirakli, C.; Su, P. L.; Kou, P. S.; Lin, W. C.; Chen, C. W.; Lozano, J. A. Benítez; Sánchez, P. Carmona; Francioni, J. E. Barrueco; Ferrón, F. Ruiz; Simón, J. M. Serrano; Riad, Z.; Mezidi, M.; Aublanc, M.; Perinel, S.; Lissonde, F.; Louf-Durier, A.; Yonis, H.; Tapponnier, R.; Richard, J. C.; Louis, B.; Guérin, C.; Mezidi, M.; Yonis, H.; Aublanc, M.; Lissonde, F.; Louf-Durier, A.; Perinel, S.; Tapponnier, R.; Richard, J. C.; Guérin, C.; Marmanidou, K.; Oikonomou, M.; Nouris, C.; Loizou, C.; Soilemezi, E.; Matamis, D.; Somhorst, P.; Gommers, D.; Hayashi, K.; Hirayama, T.; Yumoto, T.; Tsukahara, K.; Iida, A.; Nosaka, N.; Sato, K.; Ugawa, T.; Nakao, A.; Ujike, Y.; Hirohata, S.; Mojoli, F.; Torriglia, F.; Giannantonio, M.; Orlando, A.; Bianzina, S.; Tavazzi, G.; Mongodi, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Jansen, D.; Gadgil, S.; Doorduin, J.; Roesthuis, L.; van der Hoeven, J. G.; Heunks, L. M. A.; Chen, G. Q.; Sun, X. M.; He, X.; Yang, Y. L.; Shi, Z. H.; Xu, M.; Zhou, J. X.; Pereira, S. M.; Tucci, M. R.; Tonelotto, B. F. F.; Simoes, C. M.; Morais, C. C. A.; Pompeo, M. S.; Kay, F. U.; Amato, M. B. P.; Vieira, J. E.; Suzuki, S.; Mihara, Y.; Hikasa, Y.; Okahara, S.; Morimatsu, H.; Kwon, H. M.; Moon, Y. J.; Lee, S. H.; Jung, K. W.; Shin, W. J.; Jun, I. G.; Song, J. G.; Hwang, G. S.; Lee, S.; Moon, Y. J.; Kwon, H. M.; Jung, K.; Shin, W. J.; Jun, I. G.; Song, J. G.; Hwang, G. S.; Ramelli, A.; Manca, T.; Corradi, F.; Brusasco, C.; Nicolini, F.; Gherli, T.; Brianti, R.; Fanzaghi, P.; Vezzani, A.; Tudor, B. A.; Klaus, D. A.; Lebherz-Eichinger, D.; Lechner, C.; Schwarz, C.; Bodingbauer, M.; Seemann, R.; Kaczirek, K.; Fleischmann, E.; Roth, G. A.; Krenn, C. G.; Malyshev, A.; Sergey, S.; Yamaguchi, Y.; Nomura, T.; Yoshitake, E.; Idei, M.; Yoshida, T.; Takaki, S.; Yamaguchi, O.; Kaneko, M.; Goto, T.; Tencé, N.; Zaien, I.; Wolf, M.; Trouiller, P.; Jacobs, F. M.; Kelly, J. M.; Veigas, P.; Hollands, S.; Min, A.; Rizoli, S.; Robles, C. M. Coronado; de Oca Sandoval, M. A. Montes; Tarabrin, O.; Gavrychenko, D.; Mazurenko, G.; Tarabrin, P.; Garcia, I. Palacios; Martin, A. Diaz; Mendez, M. Casado; orden, V. Arellano; Noval, R. Leal; McCue, C.; Gemmell, L.; MacKay, A.; Luján, J.; Villa, P.; Llorente, B.; Molina, R.; Alcázar, L.; Juanas, C. Arenillas; Rogero, S.; Pascual, T.; Cambronero, J. A.; Almudévar, P. Matía; Domínguez, J. Palamidessi; Carmona, S. Alcántara; Castañeda, D. Palacios; Abellán, A. Naharro; Lucendo, A. Pérez; Pérez, L. Pérez; Rivas, R. Fernández; Sanz, N. Martínez; Ramos, J. Veganzones; Villamizar, P. Rodríguez; Javadpour, S.; Kalani, N.; Amininejad, T.; Jamali, S.; Sobhanian, S.; Laurent, A.; Bonnet, M.; Rigal, R.; Aslanian, P.; Hebert, P.; Capellier, G.; Contreras, M. R. Diaz; Mejías, C. Rodriguez; Ruiz, F. C. Santiago; Lombardo, M. Duro; Perez, J. Castaño; de Hoyos, E. Aguayo; Estella, A.; Viciana, R.; Fontaiña, L. Perez; Rico, T.; Madueño, V. Perez; Recuerda, M.; Fernández, L.; Sandiumenge, A.; Bonet, S.; Mazo, C.; Rubiera, M.; Ruiz-Rodríguez, J. C.; Gracia, R. M.; Espinel, E.; Pont, T.; Kotsopoulos, A.; Jansen, N.; Abdo, W. F.; Gopcevic, A.; Gavranovic, Z.; Vucic, M.; Glogoski, M. Zlatic; Penavic, L. Videc; Horvat, A.; Martin-Villen, L.; Egea-Guerero, J. J.; Revuelto-Rey, J.; Aldabo-Pallas, T.; Correa-Chamorro, E.; Gallego-Corpa, A. I.; Granados, P. Ruiz del Portal-Ruiz; Faivre, V.; Wildenberg, L.; Huot, B.; Lukaszewicz, A. C.; Simsir, M.; Mengelle, C.; Payen, D.; Sanz, N. Martinez; Valbuena, B. Lobo; de la Fuente, M. Valdivia; Almudena, P. Matía; Pérez, L. Pérez; Carmona, S. Alcántara; Abellán, A. Navarro; Simón, I. Fernández; Muñoz, J. J. Rubio; Ramos, J. Veganzones; Carmona, S. Alcantara; Almudevar, P. Matia; Abellan, A. Naharro; Lucendo, M. A. Perez; Perez, L. Perez; Dominguez, J. Palamidessi; Rivas, R. Fernandez; Villamizar, P. Rodriguez; Wee, S.; Ong, C.; Lau, Y. H.; Wong, Y.; Banderas-Bravo, M. E.; Olea-Jiménez, V.; Mora-Ordóñez, J. M.; Gómez-Jiménez, C.; Muñoz-Muñoz, J. L.; Vallejo-Báez, J.; Daga-Ruiz, D.; Lebrón-Gallardo, M.; Rialp, G.; Raurich, J. M.; Morán, I.; Martín, M. C.; Heras, G.; Mas, A.; Vallverdú, I.; Hraiech, S.; Bourenne, J.; Guervilly, C.; Forel, J. M.; Adda, M.; Sylla, P.; Mouaci, A.; Gainnier, M.; Papazian, L.; Bauer, P. R.; Kumbamu, A.; Wilson, M. E.; Pannu, J. K.; Egginton, J. S.; Kashyap, R.; Gajic, O.; Yoshihiro, S.; Sakuraya, M.; Hayakawa, M.; Hirata, A.; Kawamura, N.; Tsutui, T.; Yoshida, K.; Hashimoto, Y.; Chang, C. H.; Hu, H. C.; Chiu, L. C.; Hung, C. Y.; Li, S. H.; Kao, K. C.; Sibley, S.; Drover, J.; D’Arsigny, C.; Parker, C.; Howes, D.; Moffatt, S.; Erb, J.; Ilan, R.; Messenger, D.; Ball, I.; Boyd, J. G.; Harrison, M.; Ridi, S.; Muscedere, J.; Andrade, A. H.; Costa, R. C.; Souza, V. A.; Gonzalez, V.; Amorim, V.; Rolla, F.; Filho, C. A. C. Abreu; Miranda, R.; Atchasiri, S.; Buranavanich, P.; Wathanawatthu, T.; Suwanpasu, S.; Bureau, C.; Rolland-Debord, C.; Poitou, T.; Clavel, M.; Perbet, S.; Terzi, N.; Kouatchet, A.; Similowski, T.; Demoule, A.; Diaz, P.; Nunes, J.; Escórcio, S.; Silva, G.; Chaves, S.; Jardim, M.; Câmara, M.; Fernandes, N.; Duarte, R.; Jardim, J. J.; Pereira, C. A.; Nóbrega, J. J.; Chen, C. M.; Lai, C. C.; Cheng, K. C.; Chou, W.; Lee, S. J.; Cha, Y. S.; Lee, W. Y.; Onodera, M.; Nakataki, E.; Oto, J.; Imanaka, H.; Nishimura, M.; Khadjibaev, A.; Sabirov, D.; Rosstalnaya, A.; Akalaev, R.; Parpibaev, F.; Antonucci, E.; Rossini, P.; Gandolfi, S.; Montini, E.; Orlando, S.; van Nes, M.; Karachi, F.; Hanekom, S.; Andrade, A. H.; Pereira, U. V.; Filho, C. A. C. Abreu; Costa, R. C.; Parkin, M. S. W.; Moore, M.; Andrade, A. H.; Costa, R. C.; Carvalho, K. V. Silva; Filho, C. A. C. Abreu; Min, H. J.; Kim, H. J.; Lee, D. S.; Choi, Y. Y.; Lee, E. Y.; Song, I.; Kim, D. J.; E, Y. Y.; Kim, J. W.; Park, J. S.; Cho, Y. J.; Lee, J. H.; Suh, J. W.; Jo, Y. H.; Kim, K. S.; Lee, Y. J.; Ferrero-Calleja, J.; Merino-Vega, D.; González-Jiménez, A. I.; Sigcha, M. Sigcha; Hernández-Tejedor, A.; Martin-Vivas, A.; Gabán-Díez, Á.; Luna, R. Ruiz-de; De la Calle-Pedrosa, N.; Temprano-Gómez, I.; Afonso-Rivero, D.; Pellin-Ariño, J. I.; Algora-Weber, A.; Fumis, R. R. L.; Ferraz, A. B.; Junior, J. M. Vieira; Kirca, H.; Cakin, O.; Unal, M.; Mutlu, H.; Ramazanoglu, A.; Cengiz, M.; Nicolini, E. A.; Pelisson, F. G. F.; Nunes, R. S.; da Silva, S. L.; Carreira, M. M.; Bellissimo-Rodrigues, F.; Ferez, M. A.; Basile-Filho, A.; Chao, H. C.; Chen, C. M.; Chen, L.; Hravnak, M.; Clermont, G.; Pinsky, M.; Dubrawski, A.; Varas, J. Luján; Montero, R. Molina; Sánchez-Elvira, L. Alcázar; Díaz, P. Villa; Delgado, C. Pintado; Ruiz, B. Llorente; Guerrero, A. Pardo; Galache, J. A. Cambronero; Sherif, H.; Hassanin, H.; El Hossainy, R.; Samy, W.; Ly, H.; David, H.; Burtin, P.; Charpentier, C.; Barral, M.; Courant, P.; Fournel, E.; Gaide-Chevronnay, L.; Durand, M.; Albaladejo, P.; Payen, J. F.; Chavanon, O.; Ortiz, A. Blandino; Pozzebon, S.; Lheureux, O.; Brasseur, A.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Fumagalli, F.; Scala, S.; Affatato, R.; De Maglie, M.; Zani, D.; Novelli, D.; Marra, C.; Luciani, A.; De Zani, D.; Luini, M.; Letizia, T.; Pravettoni, D.; Staszewsky, L.; Masson, S.; Belloli, A.; Di Giancamillo, M.; Scanziani, E.; Latini, R.; Ristagno, G.; Kye, Y. C.; Suh, G. J.; Kwon, W. Y.; Kim, K. S.; Yu, K. M.; Babini, G.; Ristagno, G.; Grassi, L.; Fumagalli, F.; Bendel, S.; De Maglie, M.; Affatato, R.; Masson, S.; Latini, R.; Scanziani, E.; Reinikainen, M.; Skrifvars, M.; Kappler, F.; Blobner, M.; Schaller, S. J.; Roasio, A.; Costanzo, E.; Cardellino, S.; Iesu, E.; Cavicchi, F. Zama; Fontana, V.; Nobile, L.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Park, M.; You, K. M.; Suh, G. J.; Kwon, W. Y.; Ko, S. B.; Kim, K. S.; Xini, A.; Marca, L.; Lheureux, O.; Brasseur, A.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Beane, A.; Thilakasiri, M. C. K. T.; De Silva, A. P.; Stephens, T.; Sigera, C. S.; Athapattu, P.; Jayasinghe, S.; Padeniya, A.; Haniffa, R.; Santiago, A. Iglesias; Sáez, V. Chica; Ruiz-Ruano, R. de la Chica; González, A. Sánchez; Kunze-Szikszay, N.; Wand, S.; Klapsing, P.; Wetz, A.; Heyne, T.; Schwerdtfeger, K.; Troeltzsch, M.; Bauer, M.; Quintel, M.; Moerer, O.; Cook, D. J.; Rutherford, W. B.; Scales, D. C.; Adhikari, N. K.; Cuthbertson, B. H.; Suzuki, T.; Takei, T.; Fushimi, K.; Iwamoto, M.; Nakagawa, S.; Mendsaikhan, N.; Begzjav, T.; Lundeg, G.; Dünser, M. W.; Romero, D. González; Cabrera, J. L. Santana; Santana, J. D. Martín; Padilla, Y. Santana; Pérez, H. Rodríguez; Torrent, R. Lorenzo; Kleinpell, R.; Chouris, I.; Radu, V.; Stougianni, M.; Lavrentieva, A.; Lagonidis, D.; Price, R. D. T.; Day, A.; Arora, N.; Henderson, M. A.; Hickey, S.; Costa, M. I. Almeida; Carvalho, J. P.; Gomes, A. A.; Mergulhão, P. J.; Chan, K. K. C.; Shum, H. P.; Yan, W. W.; Maghsoudi, B.; Tabei, S. H.; Masjedi, M.; Sabetian, G.; Tabatabaei, H. R.; Akbarzadeh, A.; Saigal, S.; Pakhare, A.; Joshi, R.; Pattnaik, S. K.; Ray, B.; Rousseau, A. F.; Michel, L.; Bawin, M.; Cavalier, E.; Reginster, J. Y.; Damas, P.; Bruyere, O.; Zhou, J. C.; Cauwenberghs, H.; De Backer, A.; Neels, H.; Deblier, I.; Berghmans, J.; Himpe, D.; Barea-Mendoza, J. A.; Portillo, I. Prieto; Fernández, M. Valiente; Gigorro, R. Garcia; Vela, J. L. Perez; Mateos, H. Marín; Alves, S. Chacón; Varas, G. Morales; Rodriguez-Biendicho, A.; Carreño, E. Renes; González, J. C. Montejo; Yang, J. S.; Chiang, C. H.; Hung, W. T.; Huang, W. C.; Cheng, C. C.; Lin, K. C.; Lin, S. C.; Chiou, K. R.; Wann, S. R.; Lin, K. L.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Zhou, J. C.; Choi, Y. J.; Yoon, S. Z.; Gordillo-Brenes, A.; Fernandez-Zamora, M. D.; Perez-Borrero, L.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Herruzo-Aviles, A.; Garcia-Delgado, M.; Hinojosa-Perez, R.; Curiel-Balsera, E.; Rivera-Fernandez, R.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Hernández, A. Ansotegui; Herrera, A. N. García; Sanz, E. Regidor; Sánchez, M. J. Gómez; Hualde, J. Barado; Pascual, O. Agudo; León, J. P. Tirapu; Irazabal, J. M. Guergue; Pérez, A. González; Fernández, P. Alvarez; Amor, L. Lopéz; Albaiceta, G. Muñiz; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Hernández, A. Ansotegui; Sanz, E. Regidor; Sánchez, M. J. Gómez; Calvo, S. Aldunate; Herrera, A. N. García; Hualde, J. Barado; Pascual, O. Agudo; León, J. P. Tirapu; Corona, A.; Ruffini, C.; Spazzadeschi, A.; Marrazzo, F.; Gandola, A.; Sciurti, R.; Savi, C.; Catena, E.; Ke, M. W.; Cheng, C. C.; Huang, W. C.; Chiang, C. H.; Hung, W. T.; Lin, K. C.; Lin, S. C.; Wann, S. R.; Chiou, K. R.; Tseng, C. J.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Bertini, P.; De Sanctis, F.; Guarracino, F.; Bertini, P.; Baldassarri, R.; Guarracino, F.; Buitinck, S. H.; van der Voort, P. H. J.; Oto, J.; Nakataki, E.; Tsunano, Y.; Izawa, M.; Tane, N.; Onodera, M.; Nishimura, M.; Ghosh, S.; Gupta, A.; De Gasperi, A.; Mazza, E.; Limuti, R.; Prosperi, M.; Bissenova, N.; Yergaliyeva, A.; Talan, L.; Yılmaz, G.; Güven, G.; Yoruk, F.; Altıntas, N. D.; Mukherjee, D. N.; Agarwal, L. K.; Mandal, K.; Palomar, M.; Balsera, B.; Vallverdu, M.; Martinez, M.; Garcia, M.; Castellana, D.; Lopez, R.; Barcenilla, F.; Kaminsky, G. E.; Carreño, R.; Escribá, A.; Fuentes, M.; Gálvez, V.; Del Olmo, R.; Nieto, B.; Vaquerizo, C.; Alvarez, J.; De la Torre, M. A.; Torres, E.; Bogossian, E.; Nouer, S. Aranha; Salgado, D. Ribeiro; Brugger, S. Carvalho; Jiménez, G. Jiménez; Torner, M. Miralbés; Vidal, M. Vallverdú; Garrido, B. Balsera; Casals, X. Nuvials; Gaite, F. Barcenilla; Cabello, J. Trujillano; Martínez, M. Palomar; Doganci, M.; Izdes, S.; Besevli, S. Guzeldag; Alkan, A.; Kayaaslan, B.; Ramírez, C. Sánchez; Balcázar, L. Caipe; Santana, M. Cabrera; Viera, M. A. Hernández; Escalada, S. Hípola; Vázquez, C. F. Lübbe; Penichet, S. M. Marrero; Campelo, F. Artiles; López, M. A. De La Cal; Santana, P. Saavedra; Santana, S. Ruíz; Repessé, X.; Artiguenave, M.; Paktoris-Papine, S.; Espinasse, F.; Dinh, A.; El Sayed, F.; Charron, C.; Géri, G.; Vieillard-Baron, A.; Marmanidou, K.; Oikonomou, M.; Nouris, C.; Dimitroulakis, K.; Soilemezi, E.; Matamis, D.; Ferré, A.; Guillot, M.; Teboul, J. L.; Lichtenstein, D.; Mézière, G.; Richard, C.; Monnet, X.; Pham, T.; Beduneau, G.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Prīdāne, S.; Sabeļņikovs, O.; Mojoli, F.; Orlando, A.; Bianchi, I.; Torriglia, F.; Bianzina, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Beduneau, G.; Pham, T.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Kondili, E.; Psarologakis, C.; Kokkini, S.; Amargianitakis, V.; Babalis, D.; Chytas, A.; Chouvarda, I.; Vaporidi, K.; Georgopoulos, D.; Trapp, O.; Kalenka, A.; Mojoli, F.; Orlando, A.; Bianchi, I.; Torriglia, F.; Bianzina, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Lozano, J. A. Benítez; Sánchez, P. Carmona; Francioni, J. E. Barrueco; Ferrón, F. Ruiz; Simón, J. M. Serrano; Spadaro, S.; Karbing, D. S.; Gioia, A.; Moro, F.; Corte, F. Dalla; Mauri, T.; Volta, C. A.; Rees, S. E.; Petrova, M. V.; Mohan, R.; Butrov, A. V.; Beeharry, S. D.; Vatsik, M. V.; Sakieva, F. I.; Gobert, F.; Yonis, H.; Tapponnier, R.; Fernandez, R.; Labaune, M. A.; Burle, J. F.; Barbier, J.; Vincent, B.; Cleyet, M.; Richard, J. C.; Guérin, C.; Shinotsuka, C. Righy; Creteur, J.; Taccone, F. S.; Törnblom, S.; Nisula, S.; Vaara, S.; Poukkanen, M.; Andersson, S.; Pettilä, V.; Pesonen, E.; Xie, Z.; Liao, X.; Kang, Y.; Zhang, J.; Kubota, K.; Egi, M.; Mizobuchi, S.; Hegazy, S.; El-Keraie, A.; El Sayed, E.; El Hamid, M. Abd; Rodrigues, N. J.; Pereira, M.; Godinho, I.; Gameiro, J.; Neves, M.; Gouveia, J.; e Silva, Z. Costa; Lopes, J. A.; Mckinlay, J.; Kostalas, M.; Kooner, G.; Dudas, G.; Horton, A.; Kerr, C.; Karanjia, N.; Creagh-Brown, B.; Forni, L.; Yamazaki, A.; Ganuza, M. Sanz; Molina, J. A. Martinez; Martinez, F. Hidalgo; Freile, M. T. Chiquito; Fernandez, N. Garcia; Travieso, P. Medrano; Bandert, A.; Frithiof, R.; Lipcsey, M.; Smekal, D.; Schlaepfer, P.; Durovray, J. D.; Plouhinec, V.; Chiappa, C.; Bellomo, R.; Schneider, A. G.; Mitchell, S.; Durrant, J.; Street, H.; Dunthorne, E.; Shears, J.; Caballero, C. Hernandez; Hutchison, R.; Schwarze, S.; Ghabina, S.; Thompson, E.; Prowle, J. R.; Kirwan, C. J.; Gonzalez, C. A.; Pinto, J. L.; Orozco, V.; Patiño, J. A.; Garcia, P. K.; Contreras, K. M.; Rodriguez, P.; Echeverri, J. E. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 journal: Intensive Care Med Exp DOI: 10.1186/s40635-016-0100-7 sha: doc_id: 14533 cord_uid: 6qfecv5h file: cache/cord-015930-18qznqp0.json key: cord-015930-18qznqp0 authors: Denstaedt, Scott J.; Singer, Benjamin H. title: Hemophagocytic Lymphohistiocytosis and Other Culture Negative Sepsis-Like Syndromes in the ICU date: 2019-07-24 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-030-26710-0_79 sha: doc_id: 15930 cord_uid: 18qznqp0 file: cache/cord-014987-nycbjqn6.json key: cord-014987-nycbjqn6 authors: nan title: OP 0364-0412 date: 2006-08-24 journal: Intensive Care Med DOI: 10.1007/s00134-006-0318-z sha: doc_id: 14987 cord_uid: nycbjqn6 file: cache/cord-015334-8p124rwp.json key: cord-015334-8p124rwp authors: nan title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 journal: Pharm World Sci DOI: 10.1007/s11096-008-9226-3 sha: doc_id: 15334 cord_uid: 8p124rwp file: cache/cord-015348-qt0worsl.json key: cord-015348-qt0worsl authors: nan title: Abstract date: 2010-07-30 journal: Virchows Arch DOI: 10.1007/s00428-010-0947-z sha: doc_id: 15348 cord_uid: qt0worsl file: cache/cord-015365-iqdi99pd.json key: cord-015365-iqdi99pd authors: nan title: 25th Annual Meeting of the Austrian Society of Transplantation, Transfusion and Genetics Graz, October 19–21, 2011 date: 2011 journal: Eur Surg DOI: 10.1007/s10353-011-0041-z sha: doc_id: 15365 cord_uid: iqdi99pd file: cache/cord-015569-vy49r1zd.json key: cord-015569-vy49r1zd authors: nan title: Abstracts from the 45(th) Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7(th), 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University) date: 2012-05-17 journal: Chem Senses DOI: 10.1093/chemse/bjs052 sha: doc_id: 15569 cord_uid: vy49r1zd file: cache/cord-015946-biu5zxd1.json key: cord-015946-biu5zxd1 authors: Peng, Daizhi; Liu, Xiao title: Research Advances in Biomarker for Sepsis date: 2016-11-16 journal: Advanced Trauma and Surgery DOI: 10.1007/978-981-10-2425-2_15 sha: doc_id: 15946 cord_uid: biu5zxd1 file: cache/cord-016211-8j8n9enn.json key: cord-016211-8j8n9enn authors: Lu, Puxuan; Zhao, Qingxia title: Highly Pathogenic Avian Influenza date: 2015-04-30 journal: Radiology of Infectious Diseases: Volume 1 DOI: 10.1007/978-94-017-9882-2_18 sha: doc_id: 16211 cord_uid: 8j8n9enn file: cache/cord-016237-sk1wzghx.json key: cord-016237-sk1wzghx authors: Zhang, Chen; Myers, Jeffrey L. title: Infectious Diseases date: 2018-09-07 journal: Atlas of Lung Pathology DOI: 10.1007/978-1-4939-8689-7_4 sha: doc_id: 16237 cord_uid: sk1wzghx file: cache/cord-005814-ak5pq312.json key: cord-005814-ak5pq312 authors: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 journal: Intensive Care Med DOI: 10.1007/bf02426401 sha: doc_id: 5814 cord_uid: ak5pq312 file: cache/cord-016110-mlwe7fzz.json key: cord-016110-mlwe7fzz authors: Specks, Ulrich title: Pulmonary Manifestations of Vasculitis date: 2014-05-05 journal: Pulmonary Manifestations of Rheumatic Disease DOI: 10.1007/978-1-4939-0770-0_10 sha: doc_id: 16110 cord_uid: mlwe7fzz file: cache/cord-016248-dxk0i6t7.json key: cord-016248-dxk0i6t7 authors: Papa, Joey C.; Stolar, Charles J. H. title: Extracorporeal Membrane Oxygenation date: 2009 journal: Pediatric Surgery DOI: 10.1007/978-3-540-69560-8_32 sha: doc_id: 16248 cord_uid: dxk0i6t7 file: cache/cord-015922-5wwy0m2k.json key: cord-015922-5wwy0m2k authors: Marty, Francisco M.; Baden, Lindsey R. title: Infection in the Hematopoietic Stem Cell Transplant Recipient date: 2008 journal: Hematopoietic Stem Cell Transplantation DOI: 10.1007/978-1-59745-438-4_19 sha: doc_id: 15922 cord_uid: 5wwy0m2k file: cache/cord-016280-d47e3art.json key: cord-016280-d47e3art authors: Friedberg, Joseph S.; Kucharczuk, John C. title: Pleura: Anatomy, Physiology, and Disorders date: 2008 journal: Surgery DOI: 10.1007/978-0-387-68113-9_75 sha: doc_id: 16280 cord_uid: d47e3art file: cache/cord-015884-mtpbzgr9.json key: cord-015884-mtpbzgr9 authors: Haynes, Alice; Khardori, Nancy title: Current Practices for Infection Prevention in the Hospital Settings date: 2013-08-06 journal: Hospital Infection Prevention DOI: 10.1007/978-81-322-1608-7_3 sha: doc_id: 15884 cord_uid: mtpbzgr9 file: cache/cord-016301-vqmqnipq.json key: cord-016301-vqmqnipq authors: Winnick, Aaron M.; Karabicak, Ilhan; Distant, Dale A. title: Elderly Transplant Recipients date: 2011-01-25 journal: Principles and Practice of Geriatric Surgery DOI: 10.1007/978-1-4419-6999-6_98 sha: doc_id: 16301 cord_uid: vqmqnipq file: cache/cord-016208-u12ngkpc.json key: cord-016208-u12ngkpc authors: Andersen, Bjørg Marit title: Intensive Patient Treatment date: 2018-09-25 journal: Prevention and Control of Infections in Hospitals DOI: 10.1007/978-3-319-99921-0_45 sha: doc_id: 16208 cord_uid: u12ngkpc file: cache/cord-015126-cyhcbk1j.json key: cord-015126-cyhcbk1j authors: nan title: PS 0036-0344 date: 2007-08-25 journal: Intensive Care Med DOI: 10.1007/s00134-007-0820-y sha: doc_id: 15126 cord_uid: cyhcbk1j file: cache/cord-016135-44pgjah8.json key: cord-016135-44pgjah8 authors: Sen, Ayan; Al-Baghdadi, Rula; Al-Khafaji, Ali title: Postoperative Management of Composite Tissue Graft Transplantation date: 2016-06-03 journal: Anesthesia and Perioperative Care for Organ Transplantation DOI: 10.1007/978-1-4939-6377-5_47 sha: doc_id: 16135 cord_uid: 44pgjah8 file: cache/cord-014687-0am4l5ms.json key: cord-014687-0am4l5ms authors: nan title: SPR 2012 date: 2012-03-29 journal: Pediatr Radiol DOI: 10.1007/s00247-012-2356-8 sha: doc_id: 14687 cord_uid: 0am4l5ms file: cache/cord-014976-546zaoxn.json key: cord-014976-546zaoxn authors: nan title: Publication only date: 2006-03-08 journal: Bone Marrow Transplant DOI: 10.1038/sj.bmt.1705327 sha: doc_id: 14976 cord_uid: 546zaoxn file: cache/cord-015640-zdwmxaz3.json key: cord-015640-zdwmxaz3 authors: Tong, C. Y. W.; Schelenz, S. title: Clinical Virology in NICU, PICU and AICU date: 2011-08-10 journal: Infection Control in the Intensive Care Unit DOI: 10.1007/978-88-470-1601-9_20 sha: doc_id: 15640 cord_uid: zdwmxaz3 file: cache/cord-016498-j72vrvqf.json key: cord-016498-j72vrvqf authors: Fong, I. W. title: Issues in Community-Acquired Pneumonia date: 2020-03-07 journal: Current Trends and Concerns in Infectious Diseases DOI: 10.1007/978-3-030-36966-8_3 sha: doc_id: 16498 cord_uid: j72vrvqf file: cache/cord-015372-76xvzvdg.json key: cord-015372-76xvzvdg authors: nan title: National scientific medical meeting 1996 abstracts date: 1996 journal: Ir J Med Sci DOI: 10.1007/bf02945204 sha: doc_id: 15372 cord_uid: 76xvzvdg file: cache/cord-016105-jkaxemmb.json key: cord-016105-jkaxemmb authors: Nakao, Mutsuhiro; Takeuchi, Takeaki; He, Peisen; Ishikawa, Hirono; Kumano, Hiroaki title: Prevention and Psychological Intervention in Depression and Stress-Related Conditions date: 2011 journal: Asian Perspectives and Evidence on Health Promotion and Education DOI: 10.1007/978-4-431-53889-9_34 sha: doc_id: 16105 cord_uid: jkaxemmb file: cache/cord-016127-tbot0fc9.json key: cord-016127-tbot0fc9 authors: Hurtado, F. J.; Buroni, M.; Tenzi, J. title: Sepsis: Clinical Approach, Evidence-Based at the Bedside date: 2009-11-19 journal: Intensive and Critical Care Medicine DOI: 10.1007/978-88-470-1436-7_25 sha: doc_id: 16127 cord_uid: tbot0fc9 file: cache/cord-016177-fz48wydz.json key: cord-016177-fz48wydz authors: Bezek, Sarah; Jaung, Michael; Mackey, Joy title: Emergency Triage of Highly Infectious Diseases and Bioterrorism date: 2020-01-03 journal: Highly Infectious Diseases in Critical Care DOI: 10.1007/978-3-030-33803-9_3 sha: doc_id: 16177 cord_uid: fz48wydz file: cache/cord-016235-2lhrkmrv.json key: cord-016235-2lhrkmrv authors: Roden, Anja C.; Tazelaar, Henry D. title: Lung date: 2010-05-17 journal: Pathology of Solid Organ Transplantation DOI: 10.1007/978-3-540-79343-4_7 sha: doc_id: 16235 cord_uid: 2lhrkmrv file: cache/cord-015370-4jfgsic7.json key: cord-015370-4jfgsic7 authors: nan title: 55th Annual Meeting of the Austrian Society of Surgery: Graz, June 25—27, 2014 date: 2014-06-03 journal: Eur Surg DOI: 10.1007/s10353-014-0261-0 sha: doc_id: 15370 cord_uid: 4jfgsic7 file: cache/cord-016372-opojt70e.json key: cord-016372-opojt70e authors: DiMarco, Ross F. title: Postoperative Care of the Cardiac Surgical Patient date: 2010 journal: Surgical Intensive Care Medicine DOI: 10.1007/978-0-387-77893-8_47 sha: doc_id: 16372 cord_uid: opojt70e file: cache/cord-016413-lvb79oxo.json key: cord-016413-lvb79oxo authors: Efthimiou, Petros; Yadlapati, Sujani title: Adult-Onset Still’s Disease date: 2018-07-14 journal: Auto-Inflammatory Syndromes DOI: 10.1007/978-3-319-96929-9_19 sha: doc_id: 16413 cord_uid: lvb79oxo file: cache/cord-016460-39yniw0t.json key: cord-016460-39yniw0t authors: Ben-Chetrit, Eldad title: Colchicine date: 2018-07-31 journal: Textbook of Autoinflammation DOI: 10.1007/978-3-319-98605-0_40 sha: doc_id: 16460 cord_uid: 39yniw0t file: cache/cord-016601-gp259urb.json key: cord-016601-gp259urb authors: Bonadonna, Lucia; Briancesco, Rossella; Coccia, Anna Maria title: Analysis of Microorganisms in Hospital Environments and Potential Risks date: 2017-03-24 journal: Indoor Air Quality in Healthcare Facilities DOI: 10.1007/978-3-319-49160-8_5 sha: doc_id: 16601 cord_uid: gp259urb file: cache/cord-016871-1mlamf20.json key: cord-016871-1mlamf20 authors: Streiff, Agathe; Cotton, Bryan A. title: Hemorrhage and Transfusions in the Surgical Patient date: 2012-10-30 journal: Common Problems in Acute Care Surgery DOI: 10.1007/978-1-4614-6123-4_12 sha: doc_id: 16871 cord_uid: 1mlamf20 file: cache/cord-016300-vw11c2wt.json key: cord-016300-vw11c2wt authors: Jain, Kewal K. title: Biomarkers of Pulmonary Diseases date: 2017-09-18 journal: The Handbook of Biomarkers DOI: 10.1007/978-1-4939-7431-3_16 sha: doc_id: 16300 cord_uid: vw11c2wt file: cache/cord-016308-qzkcwrit.json key: cord-016308-qzkcwrit authors: Cochran, Christina L.; Soni, Parul P. title: Neonatal Emergencies date: 2015-11-06 journal: Clinical Pathways in Emergency Medicine DOI: 10.1007/978-81-322-2713-7_11 sha: doc_id: 16308 cord_uid: qzkcwrit file: cache/cord-016572-6fu5s89c.json key: cord-016572-6fu5s89c authors: Hage, Chadi A.; Knox, Kenneth S.; Sarosi, George A. title: Endemic mycosis date: 2005 journal: Tropical and Parasitic Infections in the Intensive Care Unit DOI: 10.1007/0-387-23380-6_12 sha: doc_id: 16572 cord_uid: 6fu5s89c file: cache/cord-015024-2xzc0uc5.json key: cord-015024-2xzc0uc5 authors: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-2001-7 sha: doc_id: 15024 cord_uid: 2xzc0uc5 file: cache/cord-017012-yl0vanuh.json key: cord-017012-yl0vanuh authors: Herberg, Jethro; Pahari, Amitava; Walters, Sam; Levin, Michael title: Infectious Diseases and the Kidney date: 2009 journal: Pediatric Nephrology DOI: 10.1007/978-3-540-76341-3_52 sha: doc_id: 17012 cord_uid: yl0vanuh file: cache/cord-014996-p6q0f37c.json key: cord-014996-p6q0f37c authors: nan title: Posters_Monday_12 October 2009 date: 2009-08-06 journal: Intensive Care Med DOI: 10.1007/s00134-009-1593-2 sha: doc_id: 14996 cord_uid: p6q0f37c file: cache/cord-015368-a0qz4tb9.json key: cord-015368-a0qz4tb9 authors: nan title: 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date: 2007 journal: Eur Surg DOI: 10.1007/s10353-007-0330-8 sha: doc_id: 15368 cord_uid: a0qz4tb9 file: cache/cord-016521-ouwwkxox.json key: cord-016521-ouwwkxox authors: Stevens, Jennifer P.; Howell, Michael D. title: Ventilator-Associated Pneumonia and Other Complications date: 2016-07-21 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-319-43341-7_29 sha: doc_id: 16521 cord_uid: ouwwkxox file: cache/cord-016814-tf17dpo5.json key: cord-016814-tf17dpo5 authors: Enes, Sara Rolandsson; Uriarte, Juan J.; Pouliot, Robert A.; Weiss, Daniel J. title: Clinical Application of Stem/Stromal Cells in COPD date: 2019-08-07 journal: Stem Cell-Based Therapy for Lung Disease DOI: 10.1007/978-3-030-29403-8_6 sha: doc_id: 16814 cord_uid: tf17dpo5 file: cache/cord-017105-mljywm9p.json key: cord-017105-mljywm9p authors: Jain, Amisha; Sami-Zakhari, Iman R. title: Pulmonary Complications of Obstetric and Gynecologic Conditions date: 2017-10-24 journal: Pulmonary Complications of Non-Pulmonary Pediatric Disorders DOI: 10.1007/978-3-319-69620-1_8 sha: doc_id: 17105 cord_uid: mljywm9p file: cache/cord-016559-tqd7m2i1.json key: cord-016559-tqd7m2i1 authors: Zheng, Yi; Zhang, Xuewen; Guo, Jiaoli title: Application in Medicine Systems date: 2014-10-28 journal: Dan Shen (Salvia miltiorrhiza) in Medicine DOI: 10.1007/978-94-017-9466-4_1 sha: doc_id: 16559 cord_uid: tqd7m2i1 file: cache/cord-016973-s32jp0ej.json key: cord-016973-s32jp0ej authors: Menon, Nithya; Reed, Mary Jane title: Respiratory Diseases of Pregnancy date: 2016-07-21 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-319-43341-7_89 sha: doc_id: 16973 cord_uid: s32jp0ej file: cache/cord-017252-88b3preq.json key: cord-017252-88b3preq authors: Morgan, Carrie I.; Shah, Samir S. title: Pneumonia date: 2014-02-20 journal: Pediatric Critical Care Medicine DOI: 10.1007/978-1-4471-6356-5_6 sha: doc_id: 17252 cord_uid: 88b3preq file: cache/cord-016476-78r0rsio.json key: cord-016476-78r0rsio authors: Jani, Meghna; Dixon, William G.; Matteson, Eric L. title: Management of the Rheumatoid Arthritis Patient with Interstitial Lung Disease date: 2017-11-29 journal: Lung Disease in Rheumatoid Arthritis DOI: 10.1007/978-3-319-68888-6_9 sha: doc_id: 16476 cord_uid: 78r0rsio file: cache/cord-016757-3d320c0a.json key: cord-016757-3d320c0a authors: nan title: Acute and chronic liver insufficiency date: 2008 journal: Hepatology Textbook and Atlas DOI: 10.1007/978-3-540-76839-5_20 sha: doc_id: 16757 cord_uid: 3d320c0a file: cache/cord-017227-66dx2dkv.json key: cord-017227-66dx2dkv authors: Humphreys, Hilary; Winter, Bob; Paul, Mical title: Immunocompromised Patients date: 2012-08-21 journal: Infections in the Adult Intensive Care Unit DOI: 10.1007/978-1-4471-4318-5_10 sha: doc_id: 17227 cord_uid: 66dx2dkv file: cache/cord-016478-gpl0zbvd.json key: cord-016478-gpl0zbvd authors: Barry, Maura; Chandra, Sunandana; Hymes, Kenneth B. title: Cytopenias in Transplant Patients date: 2018-12-08 journal: Principles and Practice of Transplant Infectious Diseases DOI: 10.1007/978-1-4939-9034-4_10 sha: doc_id: 16478 cord_uid: gpl0zbvd file: cache/cord-017040-4zajnrsf.json key: cord-017040-4zajnrsf authors: Rihana, Nancy; Sampson, Mindy title: Skin Infections date: 2019-08-11 journal: Infections in Neutropenic Cancer Patients DOI: 10.1007/978-3-030-21859-1_5 sha: doc_id: 17040 cord_uid: 4zajnrsf file: cache/cord-016960-xhzvp35g.json key: cord-016960-xhzvp35g authors: Berencsi, György; Szomor, Katalin N. title: Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy date: 2012-03-08 journal: Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis DOI: 10.1007/978-94-007-4216-1_9 sha: doc_id: 16960 cord_uid: xhzvp35g file: cache/cord-014464-m5n250r2.json key: cord-014464-m5n250r2 authors: Sole-Violan, J; Sologuren, I; Betancor, E; Zhang, S; Pérez, C; Herrera-Ramos, E; Martínez-Saavedra, M; López-Rodríguez, M; Pestano, J; Ruiz-Hernández, J; Ferrer, J; Rodríguez de Castro, F; Casanova, J; Rodríguez-Gallego, C title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 journal: Crit Care DOI: 10.1186/cc11953 sha: doc_id: 14464 cord_uid: m5n250r2 file: cache/cord-016982-qt25tp6t.json key: cord-016982-qt25tp6t authors: Fong, I. W. title: Litigations for Unexpected Adverse Events date: 2010-11-30 journal: Medico-Legal Issues in Infectious Diseases DOI: 10.1007/978-1-4419-8053-3_8 sha: doc_id: 16982 cord_uid: qt25tp6t file: cache/cord-017217-zjab7o2o.json key: cord-017217-zjab7o2o authors: Ali, Yousaf title: Self Assessment Questions date: 2008-01-08 journal: Self Assessment Questions in Rheumatology DOI: 10.1007/978-1-59745-497-1_1 sha: doc_id: 17217 cord_uid: zjab7o2o file: cache/cord-017142-vx3rgs4r.json key: cord-017142-vx3rgs4r authors: Nair, Ranjit; Patel, Krina title: What the Intensivists Need to Know About Critically Ill Myeloma Patients date: 2019-07-09 journal: Oncologic Critical Care DOI: 10.1007/978-3-319-74588-6_98 sha: doc_id: 17142 cord_uid: vx3rgs4r file: cache/cord-009567-osstpum6.json key: cord-009567-osstpum6 authors: nan title: Abstracts Oral date: 2008-04-23 journal: Am J Transplant DOI: 10.1111/j.1600-6143.2008.02254.x sha: doc_id: 9567 cord_uid: osstpum6 file: cache/cord-015352-2d02eq3y.json key: cord-015352-2d02eq3y authors: nan title: ESPR 2017 date: 2017-04-26 journal: Pediatr Radiol DOI: 10.1007/s00247-017-3820-2 sha: doc_id: 15352 cord_uid: 2d02eq3y file: cache/cord-015369-72cjogxz.json key: cord-015369-72cjogxz authors: nan title: 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date: 2009 journal: Eur Surg DOI: 10.1007/s10353-009-0461-1 sha: doc_id: 15369 cord_uid: 72cjogxz file: cache/cord-017016-twwa9djm.json key: cord-017016-twwa9djm authors: Tomashefski, Joseph F.; Dail, David H. title: Aspiration, Bronchial Obstruction, Bronchiectasis, and Related Disorders date: 2008 journal: Dail and Hammar’s Pulmonary Pathology DOI: 10.1007/978-0-387-68792-6_5 sha: doc_id: 17016 cord_uid: twwa9djm file: cache/cord-017302-xez0zso3.json key: cord-017302-xez0zso3 authors: Stephens, R. Scott title: ICU Complications of Hematopoietic Stem Cell Transplant, Including Graft vs Host Disease date: 2019-07-24 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-030-26710-0_80 sha: doc_id: 17302 cord_uid: xez0zso3 file: cache/cord-017309-pt27efu1.json key: cord-017309-pt27efu1 authors: Gupta, G. S. title: Selectins and Associated Adhesion Proteins in Inflammatory disorders date: 2012-03-20 journal: Animal Lectins: Form, Function and Clinical Applications DOI: 10.1007/978-3-7091-1065-2_44 sha: doc_id: 17309 cord_uid: pt27efu1 file: cache/cord-017350-rwqaw5ii.json key: cord-017350-rwqaw5ii authors: Venet, F.; Lepape, A.; Monneret, G. title: Monitoring Immune Dysfunction in Septic Patients: Toward Tailored Immunotherapy date: 2010-03-10 journal: Intensive Care Medicine DOI: 10.1007/978-0-387-92278-2_8 sha: doc_id: 17350 cord_uid: rwqaw5ii file: cache/cord-015306-us58wwmp.json key: cord-015306-us58wwmp authors: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 journal: Pediatr Nephrol DOI: 10.1007/s00467-013-2518-4 sha: doc_id: 15306 cord_uid: us58wwmp file: cache/cord-017324-l3d3t4wh.json key: cord-017324-l3d3t4wh authors: DjukanoviĆ, Ljubica; RadovanoviĆ, Zoran title: Balkan nephropathy date: 2008 journal: Clinical Nephrotoxins DOI: 10.1007/978-0-387-84843-3_38 sha: doc_id: 17324 cord_uid: l3d3t4wh file: cache/cord-017374-clctlm5l.json key: cord-017374-clctlm5l authors: Diamantaki, Eleni; Proklou, Athanasia; Pediaditis, Emmanouil; Amargianitakis, Vasilis; Kondili, Eumorfia title: Acute Respiratory Failure Before ICU Admission: A Practical Approach date: 2017-06-28 journal: Mechanical Ventilation in Critically Ill Cancer Patients DOI: 10.1007/978-3-319-49256-8_10 sha: doc_id: 17374 cord_uid: clctlm5l file: cache/cord-017184-1ewi3dka.json key: cord-017184-1ewi3dka authors: nan title: Primary Immunodeficiencies date: 2008 journal: Pediatric Allergy, Asthma and Immunology DOI: 10.1007/978-3-540-33395-1_22 sha: doc_id: 17184 cord_uid: 1ewi3dka file: cache/cord-017337-vq3edhxn.json key: cord-017337-vq3edhxn authors: Vincent, Jean-Louis title: PIRO: The Key to Success? date: 2009 journal: Management of Sepsis: The PIRO Approach DOI: 10.1007/978-3-642-00479-7_1 sha: doc_id: 17337 cord_uid: vq3edhxn file: cache/cord-017392-ja9b5vy9.json key: cord-017392-ja9b5vy9 authors: Waterer, G. W.; Wunderink, R. G. title: Adjunctive and Supportive Measures for Community-Acquired Pneumonia date: 2010-05-20 journal: Infectious Diseases in Critical Care DOI: 10.1007/978-3-540-34406-3_38 sha: doc_id: 17392 cord_uid: ja9b5vy9 file: cache/cord-017531-fm8gl5b3.json key: cord-017531-fm8gl5b3 authors: Andersen, Bjørg Marit title: Scenarios: Serious, Infectious Diseases date: 2018-09-25 journal: Prevention and Control of Infections in Hospitals DOI: 10.1007/978-3-319-99921-0_82 sha: doc_id: 17531 cord_uid: fm8gl5b3 file: cache/cord-017489-ftz9190a.json key: cord-017489-ftz9190a authors: Richards, Guy A.; Schleicher, Gunter; Mer, Mervyn title: Viruses in the Intensive Care Unit (ICU) date: 2005 journal: Tropical and Parasitic Infections in the Intensive Care Unit DOI: 10.1007/0-387-23380-6_3 sha: doc_id: 17489 cord_uid: ftz9190a file: cache/cord-017420-tjwxec77.json key: cord-017420-tjwxec77 authors: Stephens, R. Scott title: Neutropenic Fever in the Intensive Care Unit date: 2019-07-09 journal: Oncologic Critical Care DOI: 10.1007/978-3-319-74588-6_118 sha: doc_id: 17420 cord_uid: tjwxec77 file: cache/cord-017393-kx8kmdej.json key: cord-017393-kx8kmdej authors: Herbers, Alexandra; de Pauw, Ben E. title: Acute Myelogenous Leukemia and Febrile Neutropenia date: 2009-08-31 journal: Managing Infections in Patients With Hematological Malignancies DOI: 10.1007/978-1-59745-415-5_5 sha: doc_id: 17393 cord_uid: kx8kmdej file: cache/cord-017461-xw02c7u5.json key: cord-017461-xw02c7u5 authors: Kauffman, Carol A. title: Fungal Infections date: 2009-02-02 journal: Infectious Disease in the Aging DOI: 10.1007/978-1-60327-534-7_22 sha: doc_id: 17461 cord_uid: xw02c7u5 file: cache/cord-017518-u2gsa4lg.json key: cord-017518-u2gsa4lg authors: Divatia, J. V.; Pulinilkunnathil, Jacob George; Myatra, Sheila Nainan title: Nosocomial Infections and Ventilator-Associated Pneumonia in Cancer Patients date: 2019-07-09 journal: Oncologic Critical Care DOI: 10.1007/978-3-319-74588-6_125 sha: doc_id: 17518 cord_uid: u2gsa4lg file: cache/cord-017534-0ai8chbu.json key: cord-017534-0ai8chbu authors: Andersen, Bjørg Marit title: Background Information: Isolation Routines date: 2018-09-25 journal: Prevention and Control of Infections in Hospitals DOI: 10.1007/978-3-319-99921-0_21 sha: doc_id: 17534 cord_uid: 0ai8chbu file: cache/cord-017569-fv88n70v.json key: cord-017569-fv88n70v authors: Hewlett, Angela; Vasa, Angela M.; Cieslak, Theodore J.; Lowe, John J.; Schwedhelm, Shelly title: Viral Hemorrhagic Fever Preparedness date: 2017-09-10 journal: Infection Prevention DOI: 10.1007/978-3-319-60980-5_21 sha: doc_id: 17569 cord_uid: fv88n70v file: cache/cord-017516-qbksb83c.json key: cord-017516-qbksb83c authors: Si, Yain-Whar; Leong, Kan-Ion; Biuk-Aghai, Robert P.; Fong, Simon title: Hidden Cluster Detection for Infectious Disease Control and Quarantine Management date: 2009-09-30 journal: Visual Information Communication DOI: 10.1007/978-1-4419-0312-9_10 sha: doc_id: 17516 cord_uid: qbksb83c file: cache/cord-017581-6lubp7io.json key: cord-017581-6lubp7io authors: Glass, Daniel M.; Zehrer, Tara; Al-Khafaji, Ali title: Respiratory Diseases of Pregnancy date: 2019-07-24 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-030-26710-0_99 sha: doc_id: 17581 cord_uid: 6lubp7io file: cache/cord-017715-99ri6x0y.json key: cord-017715-99ri6x0y authors: Zhou, Bo-Ping; Lu, Pu-Xuan; Chen, Qiu; Xiao-Ping, Tang; Yu-Juan, Guan; Jin-Xin, Liu; Xing, Lu; Zhen-Wei, Lang; Xin-Chun, Chen title: SARS date: 2015-07-25 journal: Diagnostic Imaging of Emerging Infectious Diseases DOI: 10.1007/978-94-017-7363-8_2 sha: doc_id: 17715 cord_uid: 99ri6x0y file: cache/cord-017772-zpf1xjqi.json key: cord-017772-zpf1xjqi authors: Walter, James M. title: Thrombocytopenia in the Intensive Care Unit date: 2019-07-24 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-030-26710-0_83 sha: doc_id: 17772 cord_uid: zpf1xjqi file: cache/cord-017617-13m7pmvq.json key: cord-017617-13m7pmvq authors: Shah, Nirav; Bhaimia, Eric title: Traveler to Uganda date: 2017-08-25 journal: The Infectious Disease Diagnosis DOI: 10.1007/978-3-319-64906-1_1 sha: doc_id: 17617 cord_uid: 13m7pmvq file: cache/cord-017883-6a4fkd5v.json key: cord-017883-6a4fkd5v authors: Dutta, Ankhi; Flores, Ricardo title: Infection Prevention in Pediatric Oncology and Hematopoietic Stem Cell Transplant Recipients date: 2018-07-16 journal: Healthcare-Associated Infections in Children DOI: 10.1007/978-3-319-98122-2_16 sha: doc_id: 17883 cord_uid: 6a4fkd5v file: cache/cord-017897-mbwm0ytg.json key: cord-017897-mbwm0ytg authors: Chiumello, Davide; Marino, Antonella; Cammaroto, Antonio title: The Acute Respiratory Distress Syndrome: Diagnosis and Management date: 2018-10-01 journal: Practical Trends in Anesthesia and Intensive Care 2018 DOI: 10.1007/978-3-319-94189-9_11 sha: doc_id: 17897 cord_uid: mbwm0ytg file: cache/cord-017784-4r3fpmlb.json key: cord-017784-4r3fpmlb authors: Foccillo, Giampiero title: The Infections Causing Acute Respiratory Failure in Elderly Patients date: 2019-08-06 journal: Ventilatory Support and Oxygen Therapy in Elder, Palliative and End-of-Life Care Patients DOI: 10.1007/978-3-030-26664-6_5 sha: doc_id: 17784 cord_uid: 4r3fpmlb file: cache/cord-017815-0t7jvvz5.json key: cord-017815-0t7jvvz5 authors: Andersen, Bjørg Marit title: General Information date: 2018-09-25 journal: Prevention and Control of Infections in Hospitals DOI: 10.1007/978-3-319-99921-0_15 sha: doc_id: 17815 cord_uid: 0t7jvvz5 file: cache/cord-017862-9fkjjmvf.json key: cord-017862-9fkjjmvf authors: Smith, Roger P. title: Respiratory Disorders date: 2007 journal: Primary Care in Obstetrics and Gynecology DOI: 10.1007/978-0-387-32328-2_19 sha: doc_id: 17862 cord_uid: 9fkjjmvf file: cache/cord-017946-fa4ehlb0.json key: cord-017946-fa4ehlb0 authors: Lawless, Ryan A.; Cotton, Bryan A. title: Adjuncts to Resuscitation date: 2018-05-26 journal: Damage Control in Trauma Care DOI: 10.1007/978-3-319-72607-6_20 sha: doc_id: 17946 cord_uid: fa4ehlb0 file: cache/cord-018005-53cl75gk.json key: cord-018005-53cl75gk authors: Humphreys, Hilary; Winter, Bob; Paul, Mical title: Lower Respiratory Tract Infections date: 2012-08-21 journal: Infections in the Adult Intensive Care Unit DOI: 10.1007/978-1-4471-4318-5_6 sha: doc_id: 18005 cord_uid: 53cl75gk file: cache/cord-018182-lleti89n.json key: cord-018182-lleti89n authors: Kassutto, Stacey M.; Kayser, Joshua B. title: Care of the Surgical ICU Patient with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension date: 2016-10-09 journal: Principles of Adult Surgical Critical Care DOI: 10.1007/978-3-319-33341-0_13 sha: doc_id: 18182 cord_uid: lleti89n file: cache/cord-018209-v2crgj5w.json key: cord-018209-v2crgj5w authors: Pastores, Stephen M.; Dulu, Alina O.; DeSouza, Shilpa A. title: What Has Been Learned from Postmortem Studies? date: 2010-08-19 journal: Pulmonary Involvement in Patients with Hematological Malignancies DOI: 10.1007/978-3-642-15742-4_20 sha: doc_id: 18209 cord_uid: v2crgj5w file: cache/cord-017799-2nvrakbs.json key: cord-017799-2nvrakbs authors: Patel, Zara M.; Hwang, Peter H. title: Acute Bacterial Rhinosinusitis date: 2018-05-04 journal: Infections of the Ears, Nose, Throat, and Sinuses DOI: 10.1007/978-3-319-74835-1_11 sha: doc_id: 17799 cord_uid: 2nvrakbs file: cache/cord-018110-mcw4v13c.json key: cord-018110-mcw4v13c authors: Arnold, Andreas; Arnold, Wolfgang; Bovo, Roberto; Ganzer, Uwe; Hamann, Karl-Friedrich; Iurato, Salvatore; Kiefer, Jan; Lamm, Kerstin; Livi, Walter; Martini, Alessandro; O’Donoghue, Gerard M. title: Inner Ear date: 2010 journal: Otorhinolaryngology, Head and Neck Surgery DOI: 10.1007/978-3-540-68940-9_6 sha: doc_id: 18110 cord_uid: mcw4v13c file: cache/cord-017786-kfl6xt31.json key: cord-017786-kfl6xt31 authors: Curiel-Balsera, Emilio; García-Trujillo, Elena title: Guidelines for Health Organizations: European Perspectives and Experience in Pandemics date: 2013-05-29 journal: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events DOI: 10.1007/978-3-7091-1496-4_41 sha: doc_id: 17786 cord_uid: kfl6xt31 file: cache/cord-018106-5giapmcf.json key: cord-018106-5giapmcf authors: Levin, Jacqueline title: Mental Health Care for Survivors and Healthcare Workers in the Aftermath of an Outbreak date: 2019-05-16 journal: Psychiatry of Pandemics DOI: 10.1007/978-3-030-15346-5_11 sha: doc_id: 18106 cord_uid: 5giapmcf file: cache/cord-018363-qr1pk78u.json key: cord-018363-qr1pk78u authors: Casey, Ashley; Conrad, Kevin title: Consultative and Comanagement date: 2015-10-10 journal: Absolute Hospital Medicine Review DOI: 10.1007/978-3-319-23748-0_2 sha: doc_id: 18363 cord_uid: qr1pk78u file: cache/cord-018318-vzzrsqsn.json key: cord-018318-vzzrsqsn authors: Naidu, C. Sudeep; Sarin, Arti title: Postoperative Liver Failure date: 2017-02-08 journal: GI Surgery Annual DOI: 10.1007/978-981-10-2678-2_3 sha: doc_id: 18318 cord_uid: vzzrsqsn file: cache/cord-014794-yppi30a0.json key: cord-014794-yppi30a0 authors: nan title: 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date: 2003-07-31 journal: Virchows Arch DOI: 10.1007/s00428-003-0864-5 sha: doc_id: 14794 cord_uid: yppi30a0 file: cache/cord-018243-hyvu9nuq.json key: cord-018243-hyvu9nuq authors: Salman, Huda; Cooke, Kenneth R.; Lazarus, Hillard M. title: Fibrosing Alveolitis in Hematologic Malignancy Patients Undergoing Hematopoietic Cell Transplantation date: 2010-08-19 journal: Pulmonary Involvement in Patients with Hematological Malignancies DOI: 10.1007/978-3-642-15742-4_42 sha: doc_id: 18243 cord_uid: hyvu9nuq file: cache/cord-018303-dvuwhpyq.json key: cord-018303-dvuwhpyq authors: Garibaldi, Brian T.; Conger, Nicholas G.; Withers, Mark R.; Hatfill, Steven J.; Gutierrez-Nunez, Jose J.; Christopher, George W. title: Aeromedical Evacuation of Patients with Contagious Infections date: 2019-02-27 journal: Aeromedical Evacuation DOI: 10.1007/978-3-030-15903-0_20 sha: doc_id: 18303 cord_uid: dvuwhpyq file: cache/cord-018408-ttae193b.json key: cord-018408-ttae193b authors: Haddad, Imad Y.; Cornfield, David N. title: Pneumonia and Empyema date: 2008-11-15 journal: The Respiratory Tract in Pediatric Critical Illness and Injury DOI: 10.1007/978-1-84800-925-7_17 sha: doc_id: 18408 cord_uid: ttae193b file: cache/cord-018414-6ffhm895.json key: cord-018414-6ffhm895 authors: Kang, Yoogoo; Elia, Elia title: Anesthesia Management of Liver Transplantation date: 2016-07-22 journal: Contemporary Liver Transplantation DOI: 10.1007/978-3-319-07209-8_9 sha: doc_id: 18414 cord_uid: 6ffhm895 file: cache/cord-018545-fk17n2bx.json key: cord-018545-fk17n2bx authors: Dorofaeff, Tavey; Mohseni-Bod, Hadi; Cox, Peter N. title: Infections in the PICU date: 2012 journal: Textbook of Clinical Pediatrics DOI: 10.1007/978-3-642-02202-9_268 sha: doc_id: 18545 cord_uid: fk17n2bx file: cache/cord-018590-rkp89dqo.json key: cord-018590-rkp89dqo authors: Lee, Chu Keong; Foo, Schubert title: Narratives in Healthcare date: 2010-05-28 journal: Healthcare Knowledge Management DOI: 10.1007/978-0-387-49009-0_10 sha: doc_id: 18590 cord_uid: rkp89dqo file: cache/cord-018225-dozmy3lb.json key: cord-018225-dozmy3lb authors: Hawker, Felicity H. title: The liver in critical illness date: 2008 journal: Classic Papers in Critical Care DOI: 10.1007/978-1-84800-145-9_7 sha: doc_id: 18225 cord_uid: dozmy3lb file: cache/cord-018412-kv3vxmcw.json key: cord-018412-kv3vxmcw authors: Bambi, Stefano title: Evolution of Intensive Care Unit Nursing date: 2017-10-06 journal: Nursing in Critical Care Setting DOI: 10.1007/978-3-319-50559-6_19 sha: doc_id: 18412 cord_uid: kv3vxmcw file: cache/cord-018447-z4jyjczy.json key: cord-018447-z4jyjczy authors: D’Cruz, David P. title: Antiphospholipid (Hughes) Syndrome: An Overview date: 2006 journal: Hughes Syndrome DOI: 10.1007/1-84628-009-5_2 sha: doc_id: 18447 cord_uid: z4jyjczy file: cache/cord-018454-sy21cpff.json key: cord-018454-sy21cpff authors: Mitrovic, Stéphane; Feist, Eugen; Fautrel, Bruno title: Adult-Onset Still’s Disease date: 2019-10-30 journal: Periodic and Non-Periodic Fevers DOI: 10.1007/978-3-030-19055-2_6 sha: doc_id: 18454 cord_uid: sy21cpff file: cache/cord-018430-u3k8pds6.json key: cord-018430-u3k8pds6 authors: Mason, Jay W.; Trehan, Sanjeev; Renlund, Dale G. title: Myocarditis date: 2007 journal: Cardiovascular Medicine DOI: 10.1007/978-1-84628-715-2_62 sha: doc_id: 18430 cord_uid: u3k8pds6 file: cache/cord-018620-3kqx8arn.json key: cord-018620-3kqx8arn authors: Rueda, Mario; Lipsett, Pamela A. title: Hepatic Failure date: 2016-10-09 journal: Principles of Adult Surgical Critical Care DOI: 10.1007/978-3-319-33341-0_18 sha: doc_id: 18620 cord_uid: 3kqx8arn file: cache/cord-018623-of9vx7og.json key: cord-018623-of9vx7og authors: Saghazadeh, Amene; Rezaei, Nima title: The Physical Burden of Immunoperception date: 2019-04-27 journal: Biophysics and Neurophysiology of the Sixth Sense DOI: 10.1007/978-3-030-10620-1_10 sha: doc_id: 18623 cord_uid: of9vx7og file: cache/cord-018601-mk66097y.json key: cord-018601-mk66097y authors: Michelakis, Evangelos D.; Archer, Stephen L. title: Pulmonary Arterial Hypertension date: 2007 journal: Cardiovascular Medicine DOI: 10.1007/978-1-84628-715-2_108 sha: doc_id: 18601 cord_uid: mk66097y file: cache/cord-018595-x3tleomb.json key: cord-018595-x3tleomb authors: Dodiuk-Gad, Roni P.; Chung, Wen-Hung; Shear, Neil H. title: Adverse Medication Reactions date: 2017-04-25 journal: Clinical and Basic Immunodermatology DOI: 10.1007/978-3-319-29785-9_25 sha: doc_id: 18595 cord_uid: x3tleomb file: cache/cord-018801-amet0wx4.json key: cord-018801-amet0wx4 authors: Park, Caroline; Clark, Damon title: Care of the Patient with Liver Failure Requiring Transplantation date: 2018-05-04 journal: Surgical Critical Care Therapy DOI: 10.1007/978-3-319-71712-8_55 sha: doc_id: 18801 cord_uid: amet0wx4 file: cache/cord-018638-4pyjhpbk.json key: cord-018638-4pyjhpbk authors: Pilania, Rakesh Kumar; Singh, Surjit title: Kawasaki Disease date: 2019-10-30 journal: Periodic and Non-Periodic Fevers DOI: 10.1007/978-3-030-19055-2_4 sha: doc_id: 18638 cord_uid: 4pyjhpbk file: cache/cord-018780-zeok60hn.json key: cord-018780-zeok60hn authors: Biddinger, Paul D.; Shenoy, Erica S. title: Evaluation of the Person Under Investigation date: 2018-07-07 journal: Bioemergency Planning DOI: 10.1007/978-3-319-77032-1_12 sha: doc_id: 18780 cord_uid: zeok60hn file: cache/cord-018714-i291z2ju.json key: cord-018714-i291z2ju authors: Criado, Paulo Ricardo title: Adverse Drug Reactions date: 2016-12-31 journal: Dermatology in Public Health Environments DOI: 10.1007/978-3-319-33919-1_26 sha: doc_id: 18714 cord_uid: i291z2ju file: cache/cord-018809-3nrvm4jt.json key: cord-018809-3nrvm4jt authors: McMullin, N. R.; Holcomb, J. B.; Sondeen, J. title: Hemostatic Resuscitation date: 2006 journal: Yearbook of Intensive Care and Emergency Medicine DOI: 10.1007/3-540-33396-7_25 sha: doc_id: 18809 cord_uid: 3nrvm4jt file: cache/cord-018907-c84t1bo5.json key: cord-018907-c84t1bo5 authors: Bin-Hussain, Ibrahim title: Infections in the Immunocompromised Host date: 2012 journal: Textbook of Clinical Pediatrics DOI: 10.1007/978-3-642-02202-9_68 sha: doc_id: 18907 cord_uid: c84t1bo5 file: cache/cord-018834-4ligp4ak.json key: cord-018834-4ligp4ak authors: Farag, Ehab; Ebrahim, Zeyd Y. title: The Perioperative Use of Albumin date: 2016-06-23 journal: Perioperative Fluid Management DOI: 10.1007/978-3-319-39141-0_9 sha: doc_id: 18834 cord_uid: 4ligp4ak file: cache/cord-019046-q6uv2ayi.json key: cord-019046-q6uv2ayi authors: Hughes, Amy L.; Karter, Nicholas; Swanson, Douglas S. title: Laryngeal Infections date: 2015-07-14 journal: Infectious Diseases in Pediatric Otolaryngology DOI: 10.1007/978-3-319-21744-4_11 sha: doc_id: 19046 cord_uid: q6uv2ayi file: cache/cord-019010-9xgwjvsv.json key: cord-019010-9xgwjvsv authors: Luna, C. M.; Valentini, R.; Rizzo, O. title: Life-threatening Respiratory Failure from H1N1 Influenza: Lessons from the Southern Cone Outbreak date: 2010-06-23 journal: Yearbook of Intensive Care and Emergency Medicine 2010 DOI: 10.1007/978-3-642-10286-8_20 sha: doc_id: 19010 cord_uid: 9xgwjvsv file: cache/cord-019027-6chba2ru.json key: cord-019027-6chba2ru authors: Schmidt, Michael G.; Banks, Andrea L.; Salgado, Cassandra D. title: Role of the Microbial Burden in the Acquisition and Control of Healthcare Associated Infections: The Utility of Solid Copper Surfaces date: 2014-07-12 journal: Use of Biocidal Surfaces for Reduction of Healthcare Acquired Infections DOI: 10.1007/978-3-319-08057-4_4 sha: doc_id: 19027 cord_uid: 6chba2ru file: cache/cord-019043-cqmqwl3i.json key: cord-019043-cqmqwl3i authors: Fidalgo, Pedro; Bagshaw, Sean M. title: Chronic Kidney Disease in the Intensive Care Unit date: 2014-03-08 journal: Management of Chronic Kidney Disease DOI: 10.1007/978-3-642-54637-2_32 sha: doc_id: 19043 cord_uid: cqmqwl3i file: cache/cord-015021-pol2qm74.json key: cord-015021-pol2qm74 authors: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 journal: Intensive Care Med DOI: 10.1007/bf02258437 sha: doc_id: 15021 cord_uid: pol2qm74 file: cache/cord-019968-o5bdb37q.json key: cord-019968-o5bdb37q authors: Goldwater, Paul N. title: Gastroenteritis in Auckland: An aetiological and clinical study date: 2005-04-14 journal: J Infect DOI: 10.1016/s0163-4453(79)90677-7 sha: doc_id: 19968 cord_uid: o5bdb37q file: cache/cord-019064-e5z92vg8.json key: cord-019064-e5z92vg8 authors: Fox, Robert I. title: Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations date: 2011-04-12 journal: Sjögren’s Syndrome DOI: 10.1007/978-1-60327-957-4_17 sha: doc_id: 19064 cord_uid: e5z92vg8 file: cache/cord-018840-ts2g1ux7.json key: cord-018840-ts2g1ux7 authors: Katragkou, Aspasia; Roilides, Emmanuel; Walsh, Thomas J. title: Role of Immunoglobulin Therapy to Prevent and Treat Infections date: 2018-06-19 journal: Management of Infections in the Immunocompromised Host DOI: 10.1007/978-3-319-77674-3_17 sha: doc_id: 18840 cord_uid: ts2g1ux7 file: cache/cord-019063-mcxbl8mv.json key: cord-019063-mcxbl8mv authors: Vijayan, Vannan K. title: Diagnosis of Pulmonary Parasitic Diseases date: 2013-06-05 journal: Parasitic Diseases of the Lungs DOI: 10.1007/978-3-642-37609-2_1 sha: doc_id: 19063 cord_uid: mcxbl8mv file: cache/cord-019964-9leljj8j.json key: cord-019964-9leljj8j authors: nan title: Recent research in infectious disease date: 2005-01-22 journal: J Infect DOI: 10.1016/j.jinf.2004.11.005 sha: doc_id: 19964 cord_uid: 9leljj8j file: cache/cord-021713-e0hzcag6.json key: cord-021713-e0hzcag6 authors: nan title: Ribavirin date: 2015-10-21 journal: Meyler's Side Effects of Drugs DOI: 10.1016/b978-0-444-53717-1.01403-7 sha: doc_id: 21713 cord_uid: e0hzcag6 file: cache/cord-021721-80pp1ra4.json key: cord-021721-80pp1ra4 authors: Woolard, Robert H.; Borron, Stephen W.; Mackay, John M. title: Emergency Department Design date: 2015-10-23 journal: Ciottone's Disaster Medicine DOI: 10.1016/b978-0-323-28665-7.00021-2 sha: doc_id: 21721 cord_uid: 80pp1ra4 file: cache/cord-021075-8hba6au3.json key: cord-021075-8hba6au3 authors: Ouallet, J.-C.; Brochet, B. title: Aspects cliniques, physiopathologiques, et thérapeutiques de la sclérose en plaques date: 2004-07-29 journal: nan DOI: 10.1016/j.emcn.2004.05.002 sha: doc_id: 21075 cord_uid: 8hba6au3 file: cache/cord-020342-u8jzmloq.json key: cord-020342-u8jzmloq authors: nan title: Index to volume 42, January–June 2003() date: 2003-11-20 journal: Ann Emerg Med DOI: 10.1016/s0196-0644(03)01106-5 sha: doc_id: 20342 cord_uid: u8jzmloq file: cache/cord-021742-sdz6d1r5.json key: cord-021742-sdz6d1r5 authors: Karnik, Ankur A.; Karnik, Ashok M. title: Pneumothorax and Barotrauma date: 2009-05-15 journal: Critical Care Medicine DOI: 10.1016/b978-032304841-5.50050-9 sha: doc_id: 21742 cord_uid: sdz6d1r5 file: cache/cord-022050-h24f0fpd.json key: cord-022050-h24f0fpd authors: Naughton, Matthew T.; Tuxen, David V. title: Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Asthma date: 2009-05-15 journal: Clinical Critical Care Medicine DOI: 10.1016/b978-0-323-02844-8.50029-9 sha: doc_id: 22050 cord_uid: h24f0fpd file: cache/cord-021701-yan5q2r7.json key: cord-021701-yan5q2r7 authors: Woolard, Robert H. title: Emergency Department Design date: 2009-05-15 journal: Disaster Medicine DOI: 10.1016/b978-0-323-03253-7.50074-1 sha: doc_id: 21701 cord_uid: yan5q2r7 file: cache/cord-021917-z9wpjr0d.json key: cord-021917-z9wpjr0d authors: Stephens, R. Scott; Wiener, Charles M.; Rubinson, Lewis title: Bioterrorism and the Intensive Care Unit date: 2009-05-15 journal: Clinical Critical Care Medicine DOI: 10.1016/b978-0-323-02844-8.50069-x sha: doc_id: 21917 cord_uid: z9wpjr0d file: cache/cord-021816-gk8rwyq4.json key: cord-021816-gk8rwyq4 authors: Weinberger, Steven E.; Cockrill, Barbara A.; Mandel, Jess title: Pneumonia date: 2018-02-22 journal: Principles of Pulmonary Medicine DOI: 10.1016/b978-0-323-52371-4.00026-x sha: doc_id: 21816 cord_uid: gk8rwyq4 file: cache/cord-022292-msz4au4b.json key: cord-022292-msz4au4b authors: Gershan, William M. title: Cough date: 2009-05-15 journal: Practical Strategies in Pediatric Diagnosis and Therapy DOI: 10.1016/b978-0-7216-9131-2.50006-3 sha: doc_id: 22292 cord_uid: msz4au4b file: cache/cord-015359-gf32a6f1.json key: cord-015359-gf32a6f1 authors: nan title: B scientific sessions (SS) date: 2002 journal: Eur Radiol DOI: 10.1007/s00330-002-0002-9 sha: doc_id: 15359 cord_uid: gf32a6f1 file: cache/cord-021905-fjcks7w4.json key: cord-021905-fjcks7w4 authors: Win, Patrick H.; Hussain, Iftikhar title: Asthma Triggers: What Really Matters? date: 2009-05-22 journal: Clinical Asthma DOI: 10.1016/b978-032304289-5.10017-7 sha: doc_id: 21905 cord_uid: fjcks7w4 file: cache/cord-022119-bzd9e1q6.json key: cord-022119-bzd9e1q6 authors: Orzell, Susannah; Suryadevara, Amar title: Pharyngitis and Pharyngeal Space Infections: fever, sore throat, difficulty swallowing date: 2018-10-15 journal: Introduction to Clinical Infectious Diseases DOI: 10.1007/978-3-319-91080-2_5 sha: doc_id: 22119 cord_uid: bzd9e1q6 file: cache/cord-021571-7kbq0v9w.json key: cord-021571-7kbq0v9w authors: Heath, Joan A.; Zerr, Danielle M. title: Infections Acquired in the Nursery: Epidemiology and Control date: 2009-05-19 journal: Infectious Diseases of the Fetus and Newborn Infant DOI: 10.1016/b0-72-160537-0/50037-2 sha: doc_id: 21571 cord_uid: 7kbq0v9w file: cache/cord-022103-4zk8i6qb.json key: cord-022103-4zk8i6qb authors: Siegel, Jane D.; Guzman-Cottrill, Judith A. title: Pediatric Healthcare Epidemiology date: 2017-07-18 journal: Principles and Practice of Pediatric Infectious Diseases DOI: 10.1016/b978-0-323-40181-4.00002-5 sha: doc_id: 22103 cord_uid: 4zk8i6qb file: cache/cord-009997-oecpqf1j.json key: cord-009997-oecpqf1j authors: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 journal: Pediatr Blood Cancer DOI: 10.1002/pbc.27057 sha: doc_id: 9997 cord_uid: oecpqf1j file: cache/cord-022521-r72jtoso.json key: cord-022521-r72jtoso authors: Miller, Tracie L.; Cushman, Laura L. title: Gastrointestinal Complications of Secondary Immunodeficiency Syndromes date: 2010-12-27 journal: Pediatric Gastrointestinal and Liver Disease DOI: 10.1016/b978-1-4377-0774-8.10042-9 sha: doc_id: 22521 cord_uid: r72jtoso file: cache/cord-022646-f7qs1obg.json key: cord-022646-f7qs1obg authors: Frey, Noelle V.; Porter, David L. title: Hematopoietic stem cell transplantation: ASBMT/CIBMTR 2010 tandem meeting highlights and discussion date: 2010-04-27 journal: Am J Hematol DOI: 10.1002/ajh.21744 sha: doc_id: 22646 cord_uid: f7qs1obg file: cache/cord-022173-kb6mez61.json key: cord-022173-kb6mez61 authors: Calvillo Batllés, P.; Carreres Polo, J.; Sanz Caballer, J.; Salavert Lletí, M.; Compte Torrero, L. title: Hematologic neoplasms: Interpreting lung findings in chest computed tomography() date: 2015-11-06 journal: nan DOI: 10.1016/j.rxeng.2015.09.001 sha: doc_id: 22173 cord_uid: kb6mez61 file: cache/cord-023169-obupqcua.json key: cord-023169-obupqcua authors: Chierakul, Wirongrong title: Leptospirosis date: 2013-10-21 journal: Manson's Tropical Infectious Diseases DOI: 10.1016/b978-0-7020-5101-2.00038-8 sha: doc_id: 23169 cord_uid: obupqcua file: cache/cord-022658-mq91h15t.json key: cord-022658-mq91h15t authors: nan title: Executive summary date: 2008-12-30 journal: Allergy DOI: 10.1111/j.1398-9995.1998.tb04885.x sha: doc_id: 22658 cord_uid: mq91h15t file: cache/cord-022216-k4pi30sd.json key: cord-022216-k4pi30sd authors: Kliegman, Robert M. title: Neonatal necrotizing enterocolitis date: 2009-05-15 journal: Pediatric Gastrointestinal and Liver Disease DOI: 10.1016/b978-0-7216-3924-6.50047-0 sha: doc_id: 22216 cord_uid: k4pi30sd file: cache/cord-022594-fx044gcd.json key: cord-022594-fx044gcd authors: Pirko, Istvan; Noseworthy, John H. title: Demyelinating Disorders of the Central Nervous System date: 2009-05-18 journal: Textbook of Clinical Neurology DOI: 10.1016/b978-141603618-0.10048-7 sha: doc_id: 22594 cord_uid: fx044gcd file: cache/cord-023288-sqr33y72.json key: cord-023288-sqr33y72 authors: nan title: Paediatric SIG: Poster Session date: 2008-03-12 journal: Respirology DOI: 10.1111/j.1440-1843.2008.01252_11.x sha: doc_id: 23288 cord_uid: sqr33y72 file: cache/cord-022527-a0x6lws3.json key: cord-022527-a0x6lws3 authors: nan title: Eosinophils in Human Disease date: 2012-10-12 journal: Eosinophils in Health and Disease DOI: 10.1016/b978-0-12-394385-9.00013-4 sha: doc_id: 22527 cord_uid: a0x6lws3 file: cache/cord-022659-chwk2bs4.json key: cord-022659-chwk2bs4 authors: nan title: Abstracts: Poster session date: 2004-10-08 journal: Ann Neurol DOI: 10.1002/ana.410320224 sha: doc_id: 22659 cord_uid: chwk2bs4 file: cache/cord-019490-m1cuuehi.json key: cord-019490-m1cuuehi authors: nan title: Abstracts cont. date: 2015-12-28 journal: Clin Microbiol Infect DOI: 10.1111/j.1469-0691.2005.clm_1134_02.x sha: doc_id: 19490 cord_uid: m1cuuehi file: cache/cord-023168-cd7adns8.json key: cord-023168-cd7adns8 authors: Thachil, Jecko; Owusu-Ofori, Shirley; Bates, Imelda title: Haematological Diseases in the Tropics date: 2013-10-21 journal: Manson's Tropical Infectious Diseases DOI: 10.1016/b978-0-7020-5101-2.00066-2 sha: doc_id: 23168 cord_uid: cd7adns8 file: cache/cord-023622-tul7bonh.json key: cord-023622-tul7bonh authors: nan title: Rotaviruses of Man and Animals date: 1975-02-01 journal: Lancet DOI: 10.1016/s0140-6736(75)91148-4 sha: doc_id: 23622 cord_uid: tul7bonh file: cache/cord-023303-fxus38mp.json key: cord-023303-fxus38mp authors: nan title: Lung Cancer/Bronchology SIGs: Combined Poster Session date: 2008-03-12 journal: Respirology DOI: 10.1111/j.1440-1843.2008.01252_8.x sha: doc_id: 23303 cord_uid: fxus38mp file: cache/cord-023033-tgt69ir6.json key: cord-023033-tgt69ir6 authors: nan title: Poster Session (pp. 78A–178A) date: 2006-02-10 journal: Hepatology DOI: 10.1002/hep.1840380503 sha: doc_id: 23033 cord_uid: tgt69ir6 file: cache/cord-023302-p9pxz44a.json key: cord-023302-p9pxz44a authors: nan title: Cystic Fibrosis SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_7.x sha: doc_id: 23302 cord_uid: p9pxz44a file: cache/cord-023311-7wqdlha4.json key: cord-023311-7wqdlha4 authors: nan title: Oral Session date: 2010-11-24 journal: Respirology DOI: 10.1111/j.1440-1843.2010.01864.x sha: doc_id: 23311 cord_uid: 7wqdlha4 file: cache/cord-023483-owgs4syo.json key: cord-023483-owgs4syo authors: Marshall, John L; Yarden, Ronit I; Weinberg, Benjamin A title: Colorectal cancer care in the age of coronavirus: strategies to reduce risk and maintain benefit date: 2020-04-16 journal: nan DOI: 10.2217/crc-2020-0010 sha: doc_id: 23483 cord_uid: owgs4syo file: cache/cord-023669-3ataw6gy.json key: cord-023669-3ataw6gy authors: Masur, Henry title: Critically Ill Immunosuppressed Host date: 2009-05-15 journal: Critical Care Medicine DOI: 10.1016/b978-032304841-5.50056-x sha: doc_id: 23669 cord_uid: 3ataw6gy file: cache/cord-023186-gqltd6u0.json key: cord-023186-gqltd6u0 authors: nan title: Poster Sessions date: 2019-06-27 journal: Pediatr Pulmonol DOI: 10.1002/ppul.24373 sha: doc_id: 23186 cord_uid: gqltd6u0 file: cache/cord-023216-avn8f2w3.json key: cord-023216-avn8f2w3 authors: nan title: Symposium summaries date: 2004-10-18 journal: Pediatr Pulmonol DOI: 10.1002/ppul.20142 sha: doc_id: 23216 cord_uid: avn8f2w3 file: cache/cord-024233-hrzpxdh0.json key: cord-024233-hrzpxdh0 authors: nan title: In This Issue/Research Watch/News in Brief date: 2020-04-24 journal: J Thorac Oncol DOI: 10.1016/j.jtho.2020.03.017 sha: doc_id: 24233 cord_uid: hrzpxdh0 file: cache/cord-023017-k6edtg58.json key: cord-023017-k6edtg58 authors: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 journal: Hepatology DOI: 10.1002/hep.1840380505 sha: doc_id: 23017 cord_uid: k6edtg58 file: cache/cord-023308-af5nihyi.json key: cord-023308-af5nihyi authors: nan title: COPD SIG: Poster Session 2 date: 2008-03-12 journal: Respirology DOI: 10.1111/j.1440-1843.2008.01252_6.x sha: doc_id: 23308 cord_uid: af5nihyi file: cache/cord-023873-fidpskcs.json key: cord-023873-fidpskcs authors: Meersseman, Wouter title: Invasive Aspergillosis in the Intensive Care Unit: Beyond the Typical Haematological Patient date: 2009-05-04 journal: Aspergillosis: From Diagnosis to Prevention DOI: 10.1007/978-90-481-2408-4_29 sha: doc_id: 23873 cord_uid: fidpskcs file: cache/cord-023314-rwjxk8v4.json key: cord-023314-rwjxk8v4 authors: nan title: Asthma & Allergy SIG: Poster Session 1 date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_1.x sha: doc_id: 23314 cord_uid: rwjxk8v4 file: cache/cord-023729-dipjubn7.json key: cord-023729-dipjubn7 authors: Serlin, Michael H.; Dieterich, Douglas title: Gastrointestinal Disorders in HIV date: 2009-05-15 journal: Global HIV/AIDS Medicine DOI: 10.1016/b978-1-4160-2882-6.50027-7 sha: doc_id: 23729 cord_uid: dipjubn7 file: cache/cord-023305-5lb9kho6.json key: cord-023305-5lb9kho6 authors: nan title: Oliv SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_11.x sha: doc_id: 23305 cord_uid: 5lb9kho6 file: cache/cord-023343-y17z9w2x.json key: cord-023343-y17z9w2x authors: nan title: COPD SIG: Poster Session 1 date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_5.x sha: doc_id: 23343 cord_uid: y17z9w2x file: cache/cord-023298-ysur3sjq.json key: cord-023298-ysur3sjq authors: nan title: Respiratory Nurses SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_16.x sha: doc_id: 23298 cord_uid: ysur3sjq file: cache/cord-023306-3gdfo6vd.json key: cord-023306-3gdfo6vd authors: nan title: TSANZ Oral Abstracts date: 2010-03-01 journal: Respirology DOI: 10.1111/j.1440-1843.2010.01735.x sha: doc_id: 23306 cord_uid: 3gdfo6vd file: cache/cord-023331-jrvmgnu3.json key: cord-023331-jrvmgnu3 authors: nan title: Asthma & Allergy SIG: Poster Session 3. Physiology, Environment, Investigation and Management date: 2008-03-12 journal: Respirology DOI: 10.1111/j.1440-1843.2008.01252_3.x sha: doc_id: 23331 cord_uid: jrvmgnu3 file: cache/cord-024130-kgzegwon.json key: cord-024130-kgzegwon authors: Ankita; Kaur, Apjit; Saxena, Shailendra K. title: COVID-19: An Ophthalmological Update date: 2020-04-30 journal: Coronavirus Disease 2019 (COVID-19) DOI: 10.1007/978-981-15-4814-7_8 sha: doc_id: 24130 cord_uid: kgzegwon file: cache/cord-024614-6bu3zo01.json key: cord-024614-6bu3zo01 authors: Tang, Daxing; Tou, Jinfa; Wang, Jinhu; Chen, Qingjiang; Wang, Wei; Huang, Jinjin; Zhao, Hangyan; Wei, Jia; Xu, Zheming; Zhao, Dongyan; Fu, Junfen; Shu, Qiang title: Prevention and control strategies for emergency, limited-term, and elective operations in pediatric surgery during the epidemic period of COVID-19 date: 2020-03-26 journal: nan DOI: 10.1136/wjps-2020-000122 sha: doc_id: 24614 cord_uid: 6bu3zo01 file: cache/cord-023333-b7w9zrl6.json key: cord-023333-b7w9zrl6 authors: nan title: Oeld/Population Health SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_10.x sha: doc_id: 23333 cord_uid: b7w9zrl6 file: cache/cord-022653-qa1uph35.json key: cord-022653-qa1uph35 authors: nan title: Poster Discussion Session PDS date: 2017-08-30 journal: Allergy DOI: 10.1111/all.13251 sha: doc_id: 22653 cord_uid: qa1uph35 file: cache/cord-024120-3eemj37r.json key: cord-024120-3eemj37r authors: Schiff, Gordon D.; Graber, Mark L. title: An Interview with Gordon D. Schiff date: 2020-04-29 journal: Jt Comm J Qual Patient Saf DOI: 10.1016/j.jcjq.2020.04.008 sha: doc_id: 24120 cord_uid: 3eemj37r file: cache/cord-024956-oht0v33s.json key: cord-024956-oht0v33s authors: Yu, Minhua; Xu, Dan; Lan, Lan; Tu, Mengqi; Liao, Rufang; Cai, Shuhan; Cao, Yiyuan; Xu, Liying; Liao, Meiyan; Zhang, Xiaochun; Xiao, Shu-Yuan; Li, Yirong; Xu, Haibo title: Thin-section Chest CT Imaging of Coronavirus Disease 2019 Pneumonia: Comparison Between Patients with Mild and Severe Disease date: 2020-04-23 journal: Radiol Cardiothorac Imaging DOI: 10.1148/ryct.2020200126 sha: doc_id: 24956 cord_uid: oht0v33s file: cache/cord-024073-243addff.json key: cord-024073-243addff authors: Richards, Guy; Mer, Mervyn; Schleicher, Gunther; Stacey, Sarah title: COVID-19 and the Rationale for Pharmacotherapy: A South African Perspective date: 2020-04-17 journal: nan DOI: 10.18772/26180197.2020.v2nsia2 sha: doc_id: 24073 cord_uid: 243addff file: cache/cord-024893-pd67o7l8.json key: cord-024893-pd67o7l8 authors: Li, Lanjuan title: Translation: Expert Consensus on the Application of Artificial Liver Blood Purification System in the Treatment of Severe and Critical COVID-19: National Clinical Research Center for Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases date: 2020-04-17 journal: nan DOI: 10.1097/im9.0000000000000021 sha: doc_id: 24893 cord_uid: pd67o7l8 file: cache/cord-023509-tvqpv6fp.json key: cord-023509-tvqpv6fp authors: Corrin, Bryan; Nicholson, Andrew G. title: Occupational, environmental and iatrogenic lung disease date: 2011-03-02 journal: Pathology of the Lungs DOI: 10.1016/b978-0-7020-3369-8.00007-0 sha: doc_id: 23509 cord_uid: tvqpv6fp file: cache/cord-024795-xa7ke70d.json key: cord-024795-xa7ke70d authors: Kaviani, Aaron; Ince, Dilek; Axelrod, David A. title: Management of Antimicrobial Agents in Abdominal Organ Transplant Patients in Intensive Care Unit date: 2020-01-24 journal: Curr Transplant Rep DOI: 10.1007/s40472-020-00268-0 sha: doc_id: 24795 cord_uid: xa7ke70d file: cache/cord-023833-xpfibjh2.json key: cord-023833-xpfibjh2 authors: Kilickaya, O.; Bonneton, B.; Gajic, O. title: Structured Approach to Early Recognition and Treatment of Acute Critical Illness date: 2014 journal: Annual Update in Intensive Care and Emergency Medicine 2014 DOI: 10.1007/978-3-319-03746-2_51 sha: doc_id: 23833 cord_uid: xpfibjh2 file: cache/cord-025157-7b3v5yct.json key: cord-025157-7b3v5yct authors: Darreau, C.; Martino, F.; Saint-Martin, M.; Jacquier, S.; Hamel, J. F.; Nay, M. A.; Terzi, N.; Ledoux, G.; Roche-Campo, F.; Camous, L.; Pene, F.; Balzer, T.; Bagate, F.; Lorber, J.; Bouju, P.; Marois, C.; Robert, R.; Gaudry, S.; Commereuc, M.; Debarre, M.; Chudeau, N.; Labroca, P.; Merouani, K.; Egreteau, P. Y.; Peigne, V.; Bornstain, C.; Lebas, E.; Benezit, F.; Vally, S.; Lasocki, S.; Robert, A.; Delbove, A.; Lerolle, N. title: Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study date: 2020-05-24 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00668-6 sha: doc_id: 25157 cord_uid: 7b3v5yct file: cache/cord-023239-06a03o14.json key: cord-023239-06a03o14 authors: nan title: II. Topic Sessions date: 2016-06-10 journal: Pediatr Pulmonol DOI: 10.1002/ppul.23455 sha: doc_id: 23239 cord_uid: 06a03o14 file: cache/cord-024189-t7mbsr25.json key: cord-024189-t7mbsr25 authors: Weyand, Cornelia M.; Goronzy, Jörg J. title: Vasculitides date: 2008 journal: Primer on the Rheumatic Diseases DOI: 10.1007/978-0-387-68566-3_21 sha: doc_id: 24189 cord_uid: t7mbsr25 file: cache/cord-025749-mip9mkef.json key: cord-025749-mip9mkef authors: Jo, Sungyang; Chang, Jun Young; Jeong, Suyeon; Jeong, Soo; Jeon, Sang-Beom title: Newly developed stroke in patients admitted to non-neurological intensive care units date: 2020-06-02 journal: J Neurol DOI: 10.1007/s00415-020-09955-5 sha: doc_id: 25749 cord_uid: mip9mkef file: cache/cord-025666-u8w4sk07.json key: cord-025666-u8w4sk07 authors: Edgar, DW; Van Daele, U; Spronk, I; van Baar, M; van Loey, N; Wood, FM; Kazis, LB; Meirte, J title: Seeding the value based health care and standardised measurement of quality of life after burn debate date: 2020-05-30 journal: Burns DOI: 10.1016/j.burns.2020.05.024 sha: doc_id: 25666 cord_uid: u8w4sk07 file: cache/cord-019347-tj3ye1mx.json key: cord-019347-tj3ye1mx authors: nan title: ABSTRACT BOOK date: 2010-02-19 journal: Ann Allergy Asthma Immunol DOI: 10.1016/s1081-1206(10)61294-x sha: doc_id: 19347 cord_uid: tj3ye1mx file: cache/cord-027551-a92lv4sh.json key: cord-027551-a92lv4sh authors: Pinto, Eleonora; Nardi, Maria Teresa; Marchi, Rita; Cavallin, Francesco; Alfieri, Rita; Saadeh, Luca; Cagol, Matteo; Baldan, Ilaria; Saraceni, Elisabetta; Parotto, Matteo; Baratto, Fabio; Caberlotto, Cristina; Vianello, Andrea; Castoro, Carlo; Scarpa, Marco title: QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer date: 2020-06-22 journal: Support Care Cancer DOI: 10.1007/s00520-020-05573-z sha: doc_id: 27551 cord_uid: a92lv4sh file: cache/cord-024833-e6vcf4un.json key: cord-024833-e6vcf4un authors: nan title: Forum date: 2019-12-19 journal: Pharmaceut Med DOI: 10.1007/s40290-019-00321-z sha: doc_id: 24833 cord_uid: e6vcf4un file: cache/cord-025172-qg3jxgch.json key: cord-025172-qg3jxgch authors: Covarrubias, Jose; Grigorian, Areg; Kuza, Catherine M.; Dolich, Matthew; Dosch, Austin; Kojayan, Greg G.; Delaplain, Patrick; Lekawa, Michael; Nahmias, Jeffry title: Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis date: 2020-05-24 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-020-01402-4 sha: doc_id: 25172 cord_uid: qg3jxgch file: cache/cord-027805-p0bhju1s.json key: cord-027805-p0bhju1s authors: Wong, An-Kwok Ian; Cheung, Patricia C.; Happ, Mary Beth; Gay, Peter C.; Collop, Nancy A. title: Consequences and Solutions for the Impact of Communication Impairment on Noninvasive Ventilation Therapy for Acute Respiratory Failure: A Focused Review date: 2020-06-15 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000121 sha: doc_id: 27805 cord_uid: p0bhju1s file: cache/cord-025990-nj4ah2yz.json key: cord-025990-nj4ah2yz authors: Konca, Capan; Tekin, Mehmet; Geyik, Mehmet title: Susceptibility Patterns of Multidrug-Resistant Acinetobacter baumannii date: 2020-06-04 journal: Indian J Pediatr DOI: 10.1007/s12098-020-03346-4 sha: doc_id: 25990 cord_uid: nj4ah2yz file: cache/cord-025170-dtbm4ue1.json key: cord-025170-dtbm4ue1 authors: Malbrain, Manu L. N. G.; Langer, Thomas; Annane, Djillali; Gattinoni, Luciano; Elbers, Paul; Hahn, Robert G.; De laet, Inneke; Minini, Andrea; Wong, Adrian; Ince, Can; Muckart, David; Mythen, Monty; Caironi, Pietro; Van Regenmortel, Niels title: Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA) date: 2020-05-24 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00679-3 sha: doc_id: 25170 cord_uid: dtbm4ue1 file: cache/cord-026846-3u3x52f8.json key: cord-026846-3u3x52f8 authors: nan title: Inside This Issue date: 2020-06-22 journal: JACC Cardiovasc Interv DOI: 10.1016/s1936-8798(20)31180-8 sha: doc_id: 26846 cord_uid: 3u3x52f8 file: cache/cord-025176-f0frlpwh.json key: cord-025176-f0frlpwh authors: Coimbra, Raul; Edwards, Sara; Coimbra, Bruno Cammarota; Tabuenca, Arnold title: Resuming elective surgical services in times of COVID-19 infection date: 2020-05-19 journal: Trauma Surg Acute Care Open DOI: 10.1136/tsaco-2020-000511 sha: doc_id: 25176 cord_uid: f0frlpwh file: cache/cord-026879-gwzrdeb1.json key: cord-026879-gwzrdeb1 authors: Zarrintan, Armin; Javadrashid, Reza; Tarzamni, Mohammad Kazem; Zarrintan, Anita; Falahatian, Masih; Mirza-Aghazadeh-Attari, Mohammad title: Rapidly progressive COVID-19 viral pneumonia: a report of two patients with a focus on imaging findings date: 2020-06-16 journal: Egypt J Radiol Nucl Med DOI: 10.1186/s43055-020-00225-y sha: doc_id: 26879 cord_uid: gwzrdeb1 file: cache/cord-027266-jdti1pwa.json key: cord-027266-jdti1pwa authors: Derevitskii, Ilya V.; Savitskaya, Daria A.; Babenko, Alina Y.; Kovalchuk, Sergey V. title: The Atrial Fibrillation Risk Score for Hyperthyroidism Patients date: 2020-05-23 journal: Computational Science - ICCS 2020 DOI: 10.1007/978-3-030-50423-6_37 sha: doc_id: 27266 cord_uid: jdti1pwa file: cache/cord-023913-pnjhi8cu.json key: cord-023913-pnjhi8cu authors: Foreman, Stephen; Kilsdonk, Joseph; Boggs, Kelly; Mouradian, Wendy E.; Boulter, Suzanne; Casamassimo, Paul; Powell, Valerie J. H.; Piraino, Beth; Shoemaker, Wells; Kovarik, Jessica; Waxman, Evan(Jake); Cheriyan, Biju; Hood, Henry; Farman, Allan G.; Holder, Matthew; Torres-Urquidy, Miguel Humberto; Walji, Muhammad F.; Acharya, Amit; Mahnke, Andrea; Chyou, Po-Huang; Din, Franklin M.; Schrodi, Steven J. title: Broader Considerations of Medical and Dental Data Integration date: 2011-10-08 journal: Integration of Medical and Dental Care and Patient Data DOI: 10.1007/978-1-4471-2185-5_4 sha: doc_id: 23913 cord_uid: pnjhi8cu file: cache/cord-025164-hqj22yxe.json key: cord-025164-hqj22yxe authors: Renew, J. Ross; Ratzlaff, Robert; Hernandez-Torres, Vivian; Brull, Sorin J.; Prielipp, Richard C. title: Neuromuscular blockade management in the critically Ill patient date: 2020-05-24 journal: J Intensive Care DOI: 10.1186/s40560-020-00455-2 sha: doc_id: 25164 cord_uid: hqj22yxe file: cache/cord-026392-cvb44v5v.json key: cord-026392-cvb44v5v authors: Dahlberg, Jørgen; Eriksen, Camilla; Robertsen, Annette; Beitland, Sigrid title: Barriers and challenges in the process of including critically ill patients in clinical studies date: 2020-06-08 journal: Scand J Trauma Resusc Emerg Med DOI: 10.1186/s13049-020-00732-x sha: doc_id: 26392 cord_uid: cvb44v5v file: cache/cord-026653-094bk0t0.json key: cord-026653-094bk0t0 authors: Gülsen, Askin; Wedi, Bettina; Jappe, Uta title: Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events* date: 2020-06-24 journal: Allergo J DOI: 10.1007/s15007-020-2550-1 sha: doc_id: 26653 cord_uid: 094bk0t0 file: cache/cord-026991-75sbxnsc.json key: cord-026991-75sbxnsc authors: Sultan, Omar Muayad; Al-Tameemi, Haider; Alghazali, Dhia Mahdey; Abed, Mohammed; Ghniem, Muthana Naser Abu; Hawiji, Dhaffer Abdullah; Alwateefee, Enas Abdulhussain; Shubbar, Hayder Dhajir Abbas; Tauah, Amal Hussein; Ibraheem, Nisreen Mohammed; Abdulwahab, Ahmed D.; Abedtwfeq, Raad Hefdhi title: Pulmonary ct manifestations of COVID-19: changes within 2 weeks duration from presentation date: 2020-06-17 journal: Egypt J Radiol Nucl Med DOI: 10.1186/s43055-020-00223-0 sha: doc_id: 26991 cord_uid: 75sbxnsc file: cache/cord-026025-xqj877en.json key: cord-026025-xqj877en authors: PETRAS, ROBERT E.; FRANKEL, WENDY L. title: Large Intestine (Colon) date: 2009-10-30 journal: Modern Surgical Pathology DOI: 10.1016/b978-1-4160-3966-2.00023-0 sha: doc_id: 26025 cord_uid: xqj877en file: cache/cord-026868-z9gozm2w.json key: cord-026868-z9gozm2w authors: Mohammad, Abeer title: “She’s dead!” – Nursing simulation practices: A discourse analysis approach date: 2020-06-11 journal: J Public Health Res DOI: 10.4081/jphr.2020.1784 sha: doc_id: 26868 cord_uid: z9gozm2w file: cache/cord-028328-5lews3uw.json key: cord-028328-5lews3uw authors: Haas, Andrew R.; Marik, Paul E. title: COMMUNITY-ACQUIRED PNEUMONIA date: 2020-06-22 journal: Pharmacology and Therapeutics DOI: 10.1016/b978-1-4160-3291-5.50082-2 sha: doc_id: 28328 cord_uid: 5lews3uw file: cache/cord-028557-68jypaaw.json key: cord-028557-68jypaaw authors: Joshi, Jaiteerth R. title: COVSACK: an innovative portable isolated and safe COVID-19 sample collection kiosk with automatic disinfection date: 2020-07-05 journal: Trans Indian Natl DOI: 10.1007/s41403-020-00139-1 sha: doc_id: 28557 cord_uid: 68jypaaw file: cache/cord-027860-s97hdhh6.json key: cord-027860-s97hdhh6 authors: Zeimet, Anthony; McBride, David R.; Basilan, Richard; Roland, William E.; McCrary, David; Hoonmo, Koo title: Infectious Diseases date: 2020-06-22 journal: Textbook of Family Medicine DOI: 10.1016/b978-1-4377-1160-8.10016-8 sha: doc_id: 27860 cord_uid: s97hdhh6 file: cache/cord-027259-f4sgobcz.json key: cord-027259-f4sgobcz authors: Metsker, Oleg; Igor, Vozniuk; Kopanitsa, Georgy; Morozova, Elena; Maria, Prohorova title: Stroke ICU Patient Mortality Day Prediction date: 2020-05-23 journal: Computational Science - ICCS 2020 DOI: 10.1007/978-3-030-50423-6_29 sha: doc_id: 27259 cord_uid: f4sgobcz file: cache/cord-027678-k64whepc.json key: cord-027678-k64whepc authors: Chan, Kai Man; Gomersall, Charles D title: Pneumonia date: 2020-06-22 journal: Oh's Intensive Care Manual DOI: 10.1016/b978-0-7020-4762-6.00036-9 sha: doc_id: 27678 cord_uid: k64whepc file: cache/cord-028260-mja2jrgm.json key: cord-028260-mja2jrgm authors: Velasco Puyó, Pablo; Moreno, Lucas; Díaz de Heredia, Cristina; Rivière, Jacques G.; Soler Palacín, Pere title: Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome() date: 2020-07-01 journal: An Pediatr (Engl Ed) DOI: 10.1016/j.anpede.2020.05.002 sha: doc_id: 28260 cord_uid: mja2jrgm file: cache/cord-028709-r1inj3ra.json key: cord-028709-r1inj3ra authors: Spinazzola, Giorgia; Costa, Roberta; De Luca, Daniele; Chidini, Giovanna; Ferrone, Giuliano; Piastra, Marco; Conti, Giorgio title: Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study date: 2020-07-07 journal: BMC Pediatr DOI: 10.1186/s12887-020-02227-1 sha: doc_id: 28709 cord_uid: r1inj3ra file: cache/cord-028285-n4dommet.json key: cord-028285-n4dommet authors: Weilongorska, Natasha L.; Ekwobi, Chidi C. title: COVID-19: What are the challenges for NHS surgery? date: 2020-07-02 journal: Curr Probl Surg DOI: 10.1016/j.cpsurg.2020.100856 sha: doc_id: 28285 cord_uid: n4dommet file: cache/cord-028907-m9psxg1f.json key: cord-028907-m9psxg1f authors: Li, Yi; Jing, Quanmin; wang, Bing; Wang, Xiaozeng; Li, Jing; Qiao, Shubing; Chen, Shaoliang; Angiolillo, Dominick J.; Han, Yaling title: Extended antiplatelet therapy with clopidogrel alone versus clopidogrel plus aspirin after completion of 9- to 12-month dual antiplatelet therapy for ACS patients with both high bleeding and ischemic risk. Rationale and design of the OPT-BIRISK double blinded, placebo controlled randomized trial date: 2020-07-09 journal: Am Heart J DOI: 10.1016/j.ahj.2020.07.005 sha: doc_id: 28907 cord_uid: m9psxg1f file: cache/cord-027677-fc410vto.json key: cord-027677-fc410vto authors: GOULD, JANE M. title: Pharyngitis, Stomatitis, Peritonsillar, and Retropharyngeal Abscess date: 2020-06-22 journal: Pediatric Infectious Diseases DOI: 10.1016/b978-0-323-02041-1.50017-1 sha: doc_id: 27677 cord_uid: fc410vto file: cache/cord-028982-kkzpqbry.json key: cord-028982-kkzpqbry authors: Sahu, Dipit; Rathod, Vaibhavi title: Telerehabilitation during COVID 19: Shoulder rehabilitation date: 2020-07-10 journal: J Shoulder Elbow Surg DOI: 10.1016/j.jse.2020.07.001 sha: doc_id: 28982 cord_uid: kkzpqbry file: cache/cord-028379-ghudhac6.json key: cord-028379-ghudhac6 authors: Eichenberger, Emily M.; Dagher, Michael; Ruffin, Felicia; Park, Lawrence; Hersh, Lisa; Sivapalasingam, Sumathi; Fowler, Vance G.; Prasad, Brinda C. title: Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria date: 2020-07-04 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-020-03955-z sha: doc_id: 28379 cord_uid: ghudhac6 file: cache/cord-028590-rw0okd0p.json key: cord-028590-rw0okd0p authors: Westgarth, David title: What does the future hold for the workforce of tomorrow? date: 2020-07-06 journal: BDJ In Pract DOI: 10.1038/s41404-020-0457-x sha: doc_id: 28590 cord_uid: rw0okd0p file: cache/cord-022633-fr55uod6.json key: cord-022633-fr55uod6 authors: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 journal: Acad Emerg Med DOI: 10.1111/j.1553-2712.2012.01332.x sha: doc_id: 22633 cord_uid: fr55uod6 file: cache/cord-029183-3aotgq6m.json key: cord-029183-3aotgq6m authors: Monard, Céline; Pehlivan, Jonathan; Auger, Gabriel; Alviset, Sophie; Tran Dinh, Alexy; Duquaire, Paul; Gastli, Nabil; d’Humières, Camille; Maamar, Adel; Boibieux, André; Baldeyrou, Marion; Loubinoux, Julien; Dauwalder, Olivier; Cattoir, Vincent; Armand-Lefèvre, Laurence; Kernéis, Solen title: Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia date: 2020-07-14 journal: Crit Care DOI: 10.1186/s13054-020-03114-y sha: doc_id: 29183 cord_uid: 3aotgq6m file: cache/cord-015354-yknwveyz.json key: cord-015354-yknwveyz authors: nan title: Abstracts_Poster presentations date: 2007-09-18 journal: Eur J Nucl Med Mol Imaging DOI: 10.1007/s00259-007-0544-9 sha: doc_id: 15354 cord_uid: yknwveyz file: cache/cord-029211-6o7qn2y2.json key: cord-029211-6o7qn2y2 authors: nan title: Press review date: 2020-07-15 journal: J Visc Surg DOI: 10.1016/j.jviscsurg.2020.06.014 sha: doc_id: 29211 cord_uid: 6o7qn2y2 file: cache/cord-029466-9sy6icrm.json key: cord-029466-9sy6icrm authors: Ramadan, Ahmad Riad; Alsrouji, Owais K; Cerghet, Mirela; Chopp, Michael; Danoun, Omar; Grover, Kavita M; Ismail, Mohammed; Katramados, Angelos M; Mohamed, Ghada A; Mehta, Chandan B; Newman, Daniel S; Osman, Gamaleldin; Reuther, Jackie; Sallowm, Yamin; Zaman, Iram F; Barkley, Gregory L title: Tales of a department: how the COVID-19 pandemic transformed Detroit’s Henry Ford Hospital, Department of Neurology—part I: the surge date: 2020-07-12 journal: nan DOI: 10.1136/bmjno-2020-000070 sha: doc_id: 29466 cord_uid: 9sy6icrm file: cache/cord-029606-2z1tw4xo.json key: cord-029606-2z1tw4xo authors: John, Janice; Council, Lora; Zallman, Leah; Blau, Jessamyn title: Developing an Intensive Community Covid-19 Management Strategy: Helping Our Patients Access Patient-Centered Care across a Continuum of Covid-19 Disease Needs date: 2020-05-27 journal: NEJM Catal Innov Care Deliv DOI: 10.1056/cat.20.0181 sha: doc_id: 29606 cord_uid: 2z1tw4xo file: cache/cord-029112-u507i0t0.json key: cord-029112-u507i0t0 authors: Smith, Keisha; Pace, Amy; Ortiz, Stephan; Kazani, Shamsah; Rottinghaus, Scott title: A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date: 2020-07-13 journal: Trials DOI: 10.1186/s13063-020-04548-z sha: doc_id: 29112 cord_uid: u507i0t0 file: cache/cord-029626-j6b59y7a.json key: cord-029626-j6b59y7a authors: Cooley, Laura title: Fostering Human Connection in the Covid-19 Virtual Health Care Realm date: 2020-05-20 journal: NEJM Catal Innov Care Deliv DOI: 10.1056/cat.20.0166 sha: doc_id: 29626 cord_uid: j6b59y7a file: cache/cord-029612-cts1al9z.json key: cord-029612-cts1al9z authors: Kaplan, Alan; O'Neill, Daniel title: COVID-19 and Healthcare's Productivity Shock date: 2020-06-15 journal: NEJM Catal Innov Care Deliv DOI: 10.1056/cat.20.0199 sha: doc_id: 29612 cord_uid: cts1al9z file: cache/cord-029609-zh2ah34g.json key: cord-029609-zh2ah34g authors: Hamilton, Barbara C.S.; Kratz, Johannes R.; Sosa, Julie Ann; Wick, Elizabeth C. title: Developing Perioperative Covid-19 Testing Protocols to Restore Surgical Services date: 2020-06-19 journal: NEJM Catal Innov Care Deliv DOI: 10.1056/cat.20.0265 sha: doc_id: 29609 cord_uid: zh2ah34g file: cache/cord-029770-72ncfyc5.json key: cord-029770-72ncfyc5 authors: Farasat, Sadaf; Dorsch, Jennifer J.; Pearce, Alex K.; Moore, Alison A.; Martin, Jennifer L.; Malhotra, Atul; Kamdar, Biren B. title: Sleep and Delirium in Older Adults date: 2020-07-27 journal: Curr Sleep Med Rep DOI: 10.1007/s40675-020-00174-y sha: doc_id: 29770 cord_uid: 72ncfyc5 file: cache/cord-021206-4zyqqgs0.json key: cord-021206-4zyqqgs0 authors: nan title: Scientific and Educational Exhibits date: 2007 journal: nan DOI: 10.1007/s10406-007-0215-8 sha: doc_id: 21206 cord_uid: 4zyqqgs0 file: cache/cord-029615-x498xj3m.json key: cord-029615-x498xj3m authors: Kim, Michelle Kang; Rabinowitz, Loren Galler; Nagula, Satish; Dunn, Andrew; Chalil, Jason; Xu, Tao; Barna, Eric; Raucher, Beth; Thomas, David C.; Murphy, Barbara title: A Primer for Clinician Deployment to the Medicine Floors from an Epicenter of Covid-19 date: 2020-05-04 journal: NEJM Catal Innov Care Deliv DOI: 10.1056/cat.20.0180 sha: doc_id: 29615 cord_uid: x498xj3m file: cache/cord-029848-dj5xqlz1.json key: cord-029848-dj5xqlz1 authors: Mahajan, Vidushi; Singh, Tanvi; Azad, Chandrika title: Using Telemedicine During the COVID-19 Pandemic date: 2020-05-14 journal: Indian Pediatr DOI: 10.1007/s13312-020-1895-6 sha: doc_id: 29848 cord_uid: dj5xqlz1 file: cache/cord-029547-9ei1ram3.json key: cord-029547-9ei1ram3 authors: Li, Jingwei; Shao, Jun; Wang, Chengdi; Li, Weimin title: The epidemiology and therapeutic options for the COVID-19 date: 2020-05-28 journal: Precis Clin Med DOI: 10.1093/pcmedi/pbaa017 sha: doc_id: 29547 cord_uid: 9ei1ram3 file: cache/cord-029859-fhm0d9t9.json key: cord-029859-fhm0d9t9 authors: Yue, Ling; Wang, Jingyi; Ju, Mingliang; Zhu, Yi; Chen, Lianghu; Shi, Lin; Shi, Bohai; Chen, Jun; Shen, Yifeng title: How psychiatrists coordinate treatment for COVID-19: a retrospective study and experience from China date: 2020-07-21 journal: Gen Psychiatr DOI: 10.1136/gpsych-2020-100272 sha: doc_id: 29859 cord_uid: fhm0d9t9 file: cache/cord-022650-phsr10jp.json key: cord-022650-phsr10jp authors: nan title: Abstracts TPS date: 2018-08-14 journal: Allergy DOI: 10.1111/all.13539 sha: doc_id: 22650 cord_uid: phsr10jp file: cache/cord-023592-w96h4rir.json key: cord-023592-w96h4rir authors: nan title: Abstracts cont. date: 2015-12-28 journal: Clin Microbiol Infect DOI: 10.1111/j.1469-0691.2004.0902c.x sha: doc_id: 23592 cord_uid: w96h4rir file: cache/cord-030256-muah207b.json key: cord-030256-muah207b authors: Kapoor, Poonam Malhotra title: COVID-19 Thrombosis: An Unsolved Mystery date: 2020-07-24 journal: nan DOI: 10.1055/s-0040-1715279 sha: doc_id: 30256 cord_uid: muah207b file: cache/cord-022501-9wnmdvg5.json key: cord-022501-9wnmdvg5 authors: nan title: P1460 – P1884 date: 2015-12-28 journal: Clin Microbiol Infect DOI: 10.1111/j.1470-9465.2006.12_4_1431.x sha: doc_id: 22501 cord_uid: 9wnmdvg5 file: cache/cord-029991-0sy417j0.json key: cord-029991-0sy417j0 authors: Longhini, Federico; Bruni, Andrea; Garofalo, Eugenio; Ronco, Chiara; Gusmano, Andrea; Cammarota, Gianmaria; Pasin, Laura; Frigerio, Pamela; Chiumello, Davide; Navalesi, Paolo title: Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study date: 2020-08-03 journal: Crit Care DOI: 10.1186/s13054-020-03198-6 sha: doc_id: 29991 cord_uid: 0sy417j0 file: cache/cord-030254-eevqclsy.json key: cord-030254-eevqclsy authors: Mehta, Chitra; Kataria, Sushila; Mehta, Yatin title: Management of Coronavirus 2019 date: 2020-04-24 journal: nan DOI: 10.1055/s-0040-1710401 sha: doc_id: 30254 cord_uid: eevqclsy file: cache/cord-029332-yn603pvb.json key: cord-029332-yn603pvb authors: nan title: Full Issue PDF date: 2020-07-15 journal: JACC Case Rep DOI: 10.1016/s2666-0849(20)30838-x sha: doc_id: 29332 cord_uid: yn603pvb file: cache/cord-031130-xvkyt3l3.json key: cord-031130-xvkyt3l3 authors: Moreno-Duarte, Ingrid; Ghadimi, Kamrouz title: Heparin Induced Thrombocytopenia for the Perioperative and Critical Care Clinician date: 2020-08-29 journal: Curr Anesthesiol Rep DOI: 10.1007/s40140-020-00405-6 sha: doc_id: 31130 cord_uid: xvkyt3l3 file: cache/cord-010092-uftc8inx.json key: cord-010092-uftc8inx authors: nan title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 journal: Vox Sang DOI: 10.1111/vox.12792 sha: doc_id: 10092 cord_uid: uftc8inx file: cache/cord-026031-hnf5vayd.json key: cord-026031-hnf5vayd authors: Ford, Richard B.; Mazzaferro, Elisa M. title: Emergency Care date: 2009-05-21 journal: Kirk and Bistner's Handbook of Veterinary Procedures and Emergency Treatment DOI: 10.1016/b0-72-160138-3/50002-3 sha: doc_id: 26031 cord_uid: hnf5vayd file: cache/cord-031544-clzt6kyg.json key: cord-031544-clzt6kyg authors: Clavijo, Raul; Ramasamy, Ranjith; Halpern, Joshua; Melnick, Alexis; Stewart, Joshua; Rosenwaks, Zev; Brannigan, Robert title: “Online” and “at-home” versus traditional models of health care: enhancing access or impeding optimal therapeutics? date: 2020-09-08 journal: Fertil Steril DOI: 10.1016/j.fertnstert.2020.07.017 sha: doc_id: 31544 cord_uid: clzt6kyg file: cache/cord-028721-x6f26ahr.json key: cord-028721-x6f26ahr authors: Nistal, Manuel; Paniagua, Ricardo title: Non-neoplastic diseases of the testis date: 2020-06-22 journal: Urologic Surgical Pathology DOI: 10.1016/b978-0-323-01970-5.50014-2 sha: doc_id: 28721 cord_uid: x6f26ahr file: cache/cord-029150-e242o2ml.json key: cord-029150-e242o2ml authors: Du, Jiang; Fan, Ni; Zhao, Min; Hao, Wei; Liu, Tieqiao; Lu, Lin; Shi, Jie; Jiang, Haifeng; Zhong, Na; Lan, Xiaochang; Xu, Shichao; Chen, Hongxian; Xiang, Xiaojun; Wang, Xuyi; Sun, Hongqiang; Li, Bing; Ning, Yu-Ping; Li, Jing; Guo, Wanjun; Niu, Yajuan; Sheng, Lixia; Li, Yi; Liu, Xuebin; Zhou, Xuhui; Qian, Mincai; Zhou, Wenhua; Zhang, Ruiling; Hu, Hongxing; Xia, Yan; Su, Zhonghua; Zhang, Ruimin; Yang, Mei; Liu, Fen; Yuan, Wei title: Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic date: 2020-07-08 journal: Gen Psychiatr DOI: 10.1136/gpsych-2020-100252 sha: doc_id: 29150 cord_uid: e242o2ml file: cache/cord-029884-zl0uqmfi.json key: cord-029884-zl0uqmfi authors: Horowitz, Robert K.; Hogan, Laura A.; Carroll, Thomas title: MVP (Medical situation, Values and Plan): A memorable and useful model for all Serious Illness Conversations date: 2020-07-30 journal: J Pain Symptom Manage DOI: 10.1016/j.jpainsymman.2020.07.022 sha: doc_id: 29884 cord_uid: zl0uqmfi file: cache/cord-030370-89n13hml.json key: cord-030370-89n13hml authors: Brown, Colin S.; Garde, Diana; Headrick, Emily; Fitzgerald, Felicity; Hall, Andy; Harrison, Hooi-Ling; Walker, Naomi F. title: Ebola Virus Disease in the Obstetric Population date: 2019-04-11 journal: Ebola Virus Disease DOI: 10.1007/978-3-319-94854-6_4 sha: doc_id: 30370 cord_uid: 89n13hml file: cache/cord-030927-wo8r8zny.json key: cord-030927-wo8r8zny authors: Collins, Curtis D; West, Nina; Sudekum, David M; Hecht, Jason P title: Perspectives from the frontline: A pharmacy department’s response to the COVID-19 pandemic date: 2020-06-22 journal: Am J Health Syst Pharm DOI: 10.1093/ajhp/zxaa176 sha: doc_id: 30927 cord_uid: wo8r8zny file: cache/cord-021087-n4epxwn9.json key: cord-021087-n4epxwn9 authors: nan title: ECR – Final Programme: Scientific and Educational Exhibits date: 2004 journal: nan DOI: 10.1007/s10406-005-0142-5 sha: doc_id: 21087 cord_uid: n4epxwn9 file: cache/cord-030918-0w327dgj.json key: cord-030918-0w327dgj authors: Praena Crespo, Manuel; Cortés Rico, Olga title: Patient-centered primary care pediatrics. Is a paradigm change needed?() date: 2020-08-27 journal: An Pediatr (Engl Ed) DOI: 10.1016/j.anpede.2020.08.002 sha: doc_id: 30918 cord_uid: 0w327dgj file: cache/cord-030502-mvlib8ol.json key: cord-030502-mvlib8ol authors: Hatachi, Takeshi; Michihata, Nobuaki; Takeuchi, Muneyuki; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo title: Early steroid pulse therapy among children with influenza virus-associated encephalopathy date: 2020-08-12 journal: J Intensive Care DOI: 10.1186/s40560-020-00479-8 sha: doc_id: 30502 cord_uid: mvlib8ol file: cache/cord-030531-4uucx9ss.json key: cord-030531-4uucx9ss authors: Randremanana, Rindra Vatosoa; Raberahona, Mihaja; Randria, Mamy Jean de Dieu; Rajerison, Minoarisoa; Andrianaivoarimanana, Voahangy; Legrand, Agathe; Rasoanaivo, Tsinjo Fehizoro; Randriamparany, Ravaka; Mayouya-Gamana, Théodora; Mangahasimbola, Reziky; Bourner, Josie; Salam, Alex; Gillesen, Annelies; Edwards, Tansy; Schoenhals, Matthieu; Baril, Laurence; Horby, Peter; Olliaro, Piero title: An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial date: 2020-08-17 journal: Trials DOI: 10.1186/s13063-020-04642-2 sha: doc_id: 30531 cord_uid: 4uucx9ss file: cache/cord-031129-wqkdug42.json key: cord-031129-wqkdug42 authors: Carr, Zyad J.; Klick, John; McDowell, Brittany J.; Charchaflieh, Jean G.; Karamchandani, Kunal title: An Update on Systemic Sclerosis and its Perioperative Management date: 2020-08-29 journal: Curr Anesthesiol Rep DOI: 10.1007/s40140-020-00411-8 sha: doc_id: 31129 cord_uid: wqkdug42 file: cache/cord-030149-hkpjnqm9.json key: cord-030149-hkpjnqm9 authors: Fioratti, Iuri; Fernandes, Lívia G.; Reis, Felipe J.; Saragiotto, Bruno T. title: Strategies for a safe and assertive telerehabilitation practice date: 2020-08-07 journal: Braz J Phys Ther DOI: 10.1016/j.bjpt.2020.07.009 sha: doc_id: 30149 cord_uid: hkpjnqm9 file: cache/cord-023354-f2ciho6o.json key: cord-023354-f2ciho6o authors: nan title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 journal: Vox Sang DOI: 10.1111/j.1423-0410.2005.00654.x sha: doc_id: 23354 cord_uid: f2ciho6o file: cache/cord-030369-4dn02a35.json key: cord-030369-4dn02a35 authors: Peng, Liang; Gao, Zhi-Liang; Wang, Yu-Ming; He, Deng-Ming; Zhao, Jing-Ming; Bai, Xue-Fan; Wang, Xiao-Jing title: Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure) date: 2019-05-21 journal: Acute Exacerbation of Chronic Hepatitis B DOI: 10.1007/978-94-024-1603-9_1 sha: doc_id: 30369 cord_uid: 4dn02a35 file: cache/cord-030897-c88tjrai.json key: cord-030897-c88tjrai authors: Aljohani, Amal H.; Al-Mousa, Hamoud; Arnaout, Rand; Al-Dhekri, Hasan; Mohammed, Reem; Alsum, Zobaida; Nicolas-Jilwan, Manal; Alrogi, Fayhan; Al-Muhsen, Saleh; Alazami, Anas M.; Al-Saud, Bandar title: Clinical and Immunological Characterization of Combined Immunodeficiency Due to TFRC Mutation in Eight Patients date: 2020-08-27 journal: J Clin Immunol DOI: 10.1007/s10875-020-00851-1 sha: doc_id: 30897 cord_uid: c88tjrai file: cache/cord-032588-8bfl2qy1.json key: cord-032588-8bfl2qy1 authors: nan title: 51. Jahrestagung der Österreichischen Gesellschaft für Innere Medizin date: 2020-09-18 journal: Wien Klin Wochenschr DOI: 10.1007/s00508-020-01724-8 sha: doc_id: 32588 cord_uid: 8bfl2qy1 file: cache/cord-023346-8sqbqjm1.json key: cord-023346-8sqbqjm1 authors: nan title: MONDAY: POSTERS date: 2005-06-08 journal: Vox Sang DOI: 10.1111/j.1423-0410.2005.00652.x sha: doc_id: 23346 cord_uid: 8sqbqjm1 file: cache/cord-005460-ezrn8cva.json key: cord-005460-ezrn8cva authors: nan title: Physicians – Poster Session date: 2017-07-28 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2017.134 sha: doc_id: 5460 cord_uid: ezrn8cva file: cache/cord-024651-578c9ut5.json key: cord-024651-578c9ut5 authors: nan title: 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2020-05-11 journal: J Clin Immunol DOI: 10.1007/s10875-020-00764-z sha: doc_id: 24651 cord_uid: 578c9ut5 file: cache/cord-032335-6c9gt7t9.json key: cord-032335-6c9gt7t9 authors: Segrelles-Calvo, Gonzalo; de Granda-Orive, José Ignacio; López-Padilla, Daniel; Zamora García, Enrique title: Therapeutic limitation in elderly patients: Reflections regarding COVID19() date: 2020-09-19 journal: Arch Bronconeumol DOI: 10.1016/j.arbr.2020.05.008 sha: doc_id: 32335 cord_uid: 6c9gt7t9 file: cache/cord-033279-bcf9568a.json key: cord-033279-bcf9568a authors: Vujaklija Brajković, Ana; Košuta, Iva; Tomek, Dora; Rora, Mia; Babel, Jakša; Rogić, Dunja; Lončar Vrančić, Ana; Radonić, Radovan title: Utility of procalcitonin in a medical intensive care unit in Croatia date: 2020-10-06 journal: Wien Klin Wochenschr DOI: 10.1007/s00508-020-01747-1 sha: doc_id: 33279 cord_uid: bcf9568a file: cache/cord-031710-1xl2isee.json key: cord-031710-1xl2isee authors: Andrei, Stefan; Ghiaur, Alexandra; Brezeanu, Lavinia; Martac, Cristina; Nicolau, Andreea; Coriu, Daniel; Droc, Gabriela title: Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia – case report date: 2020-09-10 journal: BMC Infect Dis DOI: 10.1186/s12879-020-05378-9 sha: doc_id: 31710 cord_uid: 1xl2isee file: cache/cord-030216-l38i06v2.json key: cord-030216-l38i06v2 authors: Liao, Kuang-Ming; Kuo, Lu-Ting; Lu, Hsueh-Yi title: Hospital costs and prognosis in end-stage renal disease patients receiving coronary artery bypass grafting date: 2020-08-08 journal: BMC Nephrol DOI: 10.1186/s12882-020-01972-w sha: doc_id: 30216 cord_uid: l38i06v2 file: cache/cord-023049-fio7cjj5.json key: cord-023049-fio7cjj5 authors: nan title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date: 2017-06-22 journal: J Peripher Nerv Syst DOI: 10.1111/jns.12225 sha: doc_id: 23049 cord_uid: fio7cjj5 file: cache/cord-030380-okue1kso.json key: cord-030380-okue1kso authors: McWilliams, J. Michael title: Professionalism Revealed: Rethinking Quality Improvement in the Wake of a Pandemic date: 2020-07-22 journal: NEJM Catal Innov Care Deliv DOI: 10.1056/cat.20.0226 sha: doc_id: 30380 cord_uid: okue1kso file: cache/cord-031558-8wysernx.json key: cord-031558-8wysernx authors: Michas, Marta; Deuchar, Lesly; Leigh, Richard; Bhutani, Mohit; Rowe, Brian H.; Stickland, Michael K.; Ospina, Maria B. title: Factors influencing the implementation and uptake of a discharge care bundle for patients with acute exacerbation of chronic obstructive pulmonary disease: a qualitative focus group study date: 2020-08-21 journal: Implement Sci Commun DOI: 10.1186/s43058-020-00017-5 sha: doc_id: 31558 cord_uid: 8wysernx file: cache/cord-030962-2xem8inu.json key: cord-030962-2xem8inu authors: Isea de la Viña, Jesus; Mayol, Julio; Ortega, Ana Laura; Alcázar Navarrete, Bernardino title: Lung cancer patients on the waiting list in the midst of the COVID-19 crisis: what do we do now?() date: 2020-08-28 journal: Arch Bronconeumol DOI: 10.1016/j.arbr.2020.05.003 sha: doc_id: 30962 cord_uid: 2xem8inu file: cache/cord-031256-4mxt501d.json key: cord-031256-4mxt501d authors: Van Der Poorten, Marie-Line M.; Van Gasse, Athina L.; Hagendorens, Margo M.; Faber, Margaretha A.; De Puysseleyr, Leander; Elst, Jessy; Mertens, Christel M.; Romano, Antonino; Ebo, Didier G.; Sabato, Vito title: Non-irritating skin test concentrations for ceftazidime and aztreonam in patients with a documented beta-lactam allergy. date: 2020-09-01 journal: J Allergy Clin Immunol Pract DOI: 10.1016/j.jaip.2020.08.031 sha: doc_id: 31256 cord_uid: 4mxt501d file: cache/cord-034157-uif9xtvl.json key: cord-034157-uif9xtvl authors: Ortoleva, Jamel title: Anesthetic Considerations for Recovered COVID-19 Patients date: 2020-10-22 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.10.032 sha: doc_id: 34157 cord_uid: uif9xtvl file: cache/cord-023364-ut56gczm.json key: cord-023364-ut56gczm authors: nan title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 journal: Vox Sang DOI: 10.1111/j.1423-0410.2005.00651.x sha: doc_id: 23364 cord_uid: ut56gczm file: cache/cord-030361-0tepkjdl.json key: cord-030361-0tepkjdl authors: Mohammed Abdul, Mubeen Khan; Snyder, Heather S.; Chunduru, Mythili; Lee, Susan M.K.; Satapathy, Sanjaya K. title: Hepatitis C Virus in the Elderly in the Direct-Acting Antiviral Era: from Diagnosis to Cure date: 2020-08-11 journal: Curr Treat Options Infect Dis DOI: 10.1007/s40506-020-00231-8 sha: doc_id: 30361 cord_uid: 0tepkjdl file: cache/cord-032544-2yrqjw1o.json key: cord-032544-2yrqjw1o authors: Haroon, Sabrina-Wong-Peixin; Tai, Bee-Choo; Ling, Lieng-Hsi; Teo, Lynette; Davenport, Andrew; Schurgers, Leon; Teo, Boon-Wee; Khatri, Priyanka; Ong, Ching-Ching; Low, Sanmay; Yeo, Xi-Er; Tan, Jia-Neng; Subramanian, Srinivas; Chua, Horng-Ruey; Tan, Swee-Yaw; Wong, Weng-Kin; Lau, Titus-Wai-Leong title: Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial date: 2020-09-04 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000021906 sha: doc_id: 32544 cord_uid: 2yrqjw1o file: cache/cord-032928-m0awip9y.json key: cord-032928-m0awip9y authors: Sobh, Eman; Abuarrah, Einas; Abdelsalam, Khloud Gamal; Awad, Sohaila Sabry; Badawy, Mohamed Ahmed; Fathelbab, Mohamed A.; Aboulfotouh, Mohamed Ahmed; Awadallah, Mohamed Fawzi title: Novel coronavirus disease 2019 (COVID-19) non-respiratory involvement date: 2020-10-01 journal: Egypt J Bronchol DOI: 10.1186/s43168-020-00030-1 sha: doc_id: 32928 cord_uid: m0awip9y file: cache/cord-032392-ex3s8evv.json key: cord-032392-ex3s8evv authors: Matthews, Tamyra; Baken, Donald; Ross, Kirsty title: Single cases from multiple perspectives: a qualitative study comparing the experiences of patients, patients’ caregivers, surgeons, and nurses when bad news is delivered about cancer date: 2020-09-18 journal: J Psychosoc Oncol Res Pract DOI: 10.1097/or9.0000000000000032 sha: doc_id: 32392 cord_uid: ex3s8evv file: cache/cord-033247-2cbslnb7.json key: cord-033247-2cbslnb7 authors: Alsaied, Tarek; Ashfaq, Awais title: From Other Journals: A Review of Recent Articles in Pediatric Cardiology date: 2020-10-06 journal: Pediatr Cardiol DOI: 10.1007/s00246-020-02478-w sha: doc_id: 33247 cord_uid: 2cbslnb7 file: cache/cord-023157-0lqlx2rv.json key: cord-023157-0lqlx2rv authors: nan title: Poster Sessions date: 2013-04-18 journal: J Diabetes DOI: 10.1111/1753-0407.12032_1 sha: doc_id: 23157 cord_uid: 0lqlx2rv file: cache/cord-031734-5wnvuk2n.json key: cord-031734-5wnvuk2n authors: Wichlas, F.; Hofmann, V.; Strada, G.; Deininger, C. title: War surgery in Afghanistan: a model for mass causalities in terror attacks? date: 2020-09-11 journal: Int Orthop DOI: 10.1007/s00264-020-04797-2 sha: doc_id: 31734 cord_uid: 5wnvuk2n file: cache/cord-031821-rywdkqcd.json key: cord-031821-rywdkqcd authors: Borregón Rivilla, Miguel; Martínez Barroso, Katherin Aly title: Coronavirus infection in cancer patients, last update() date: 2020-09-12 journal: Med Clin (Engl Ed) DOI: 10.1016/j.medcle.2020.05.021 sha: doc_id: 31821 cord_uid: rywdkqcd file: cache/cord-033135-cxsmxk3b.json key: cord-033135-cxsmxk3b authors: Palomo Cobos, Luis; Corrales Nevado, Dolores title: Chronicity and primary care in times of pandemic() date: 2020-10-03 journal: nan DOI: 10.1016/j.sedeng.2020.05.002 sha: doc_id: 33135 cord_uid: cxsmxk3b file: cache/cord-033965-c1i7dnnt.json key: cord-033965-c1i7dnnt authors: Christian, Ashton B.; Grigorian, Areg; Nahmias, Jeffry; Duong, William Q.; Lekawa, Michael; Joe, Victor; Dolich, Matthew; Schubl, Sebastian D. title: Comparison of surgical fixation and non-operative management in patients with traumatic sternum fracture date: 2020-10-19 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-020-01527-6 sha: doc_id: 33965 cord_uid: c1i7dnnt file: cache/cord-031191-63xtga7h.json key: cord-031191-63xtga7h authors: Barrios Espinosa, Cristian; Hemels, Martin E.W.; Dobrev, Dobromir; Heijman, Jordi title: Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication date: 2020-08-06 journal: Int J Cardiol Heart Vasc DOI: 10.1016/j.ijcha.2020.100609 sha: doc_id: 31191 cord_uid: 63xtga7h file: cache/cord-033778-u2r0neyc.json key: cord-033778-u2r0neyc authors: Taban, EM; Richards, GA title: Observational study of therapeutic bronchoscopy in critical hypoxaemic ventilated patients with COVID-19 at Mediclinic Midstream Private Hospital in Pretoria, South Africa date: 2020-10-13 journal: nan DOI: 10.7196/ajtccm.2020.v26i4.119 sha: doc_id: 33778 cord_uid: u2r0neyc file: cache/cord-034257-kl2ccmz5.json key: cord-034257-kl2ccmz5 authors: de Jonge, Jeroen C.; Woodhouse, Lisa J.; Reinink, Hendrik; van der Worp, H. Bart; Bath, Philip M. title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date: 2020-10-26 journal: Trials DOI: 10.1186/s13063-020-04717-0 sha: doc_id: 34257 cord_uid: kl2ccmz5 file: cache/cord-033574-4y53ryoa.json key: cord-033574-4y53ryoa authors: Tashiro, Hiroki; Takahashi, Koichiro; Sadamatsu, Hironori; Kurihara, Yuki; Haraguchi, Tetsuro; Tajiri, Ryo; Takamori, Ayako; Kimura, Shinya; Sueoka-Aragane, Naoko title: Biomarkers for Overweight in Adult-Onset Asthma date: 2020-10-02 journal: J Asthma Allergy DOI: 10.2147/jaa.s276371 sha: doc_id: 33574 cord_uid: 4y53ryoa file: cache/cord-022888-dnsdg04n.json key: cord-022888-dnsdg04n authors: nan title: Poster Sessions date: 2009-08-19 journal: Eur J Immunol DOI: 10.1002/eji.200990224 sha: doc_id: 22888 cord_uid: dnsdg04n file: cache/cord-034036-1wigu3i3.json key: cord-034036-1wigu3i3 authors: Yu, Changhao; Zhou, Dong; Jiang, Weijia; Mu, Jie title: Current epidemiological and etiological characteristics and treatment of seizures or epilepsy in patients with HIV infection date: 2020-10-21 journal: Acta Epileptologica DOI: 10.1186/s42494-020-00028-8 sha: doc_id: 34036 cord_uid: 1wigu3i3 file: cache/cord-031497-pp0p3en6.json key: cord-031497-pp0p3en6 authors: Rodríguez-Fuster, Alberto; Espases, Rafael Aguiló; Ventura, Juan Fontané; Bartolomé, Ramón Adália; Navas, Saida Sánchez; Belda-Sanchis, José title: Tracheal trauma in the context of the current infection by COVID-19. About 2 cases() date: 2020-09-06 journal: Arch Bronconeumol DOI: 10.1016/j.arbr.2020.08.007 sha: doc_id: 31497 cord_uid: pp0p3en6 file: cache/cord-033327-yi1tvsh4.json key: cord-033327-yi1tvsh4 authors: nan title: AANP Forum date: 2020-10-08 journal: J Nurse Pract DOI: 10.1016/j.nurpra.2020.08.025 sha: doc_id: 33327 cord_uid: yi1tvsh4 file: cache/cord-015324-y44sfr0c.json key: cord-015324-y44sfr0c authors: nan title: Scientific Programme date: 2007-09-01 journal: Pediatr Nephrol DOI: 10.1007/s00467-007-0558-3 sha: doc_id: 15324 cord_uid: y44sfr0c file: cache/cord-032930-ohsh46l2.json key: cord-032930-ohsh46l2 authors: Liu, Priscila Menezes Ferri; de Carvalho, Sarah Tayná; Fradico, Pollyanna Faria; Cazumbá, Maria Luiza Barreto; Campos, Ramon Gustavo Bernardino; Simões e Silva, Ana Cristina title: Hepatorenal syndrome in children: a review date: 2020-10-01 journal: Pediatr Nephrol DOI: 10.1007/s00467-020-04762-6 sha: doc_id: 32930 cord_uid: ohsh46l2 file: cache/cord-034286-m1c98nv7.json key: cord-034286-m1c98nv7 authors: Wijdicks, Eelco F. M. title: Communicating Neurocritical Illness: The Anatomy of Misunderstanding date: 2020-10-27 journal: Neurocrit Care DOI: 10.1007/s12028-020-01131-x sha: doc_id: 34286 cord_uid: m1c98nv7 file: cache/cord-033019-4eo037jp.json key: cord-033019-4eo037jp authors: Garnier, Marc; Velly, Lionel title: Answer to the letter by Niño et al date: 2020-10-02 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.09.006 sha: doc_id: 33019 cord_uid: 4eo037jp file: cache/cord-032183-yqqqe325.json key: cord-032183-yqqqe325 authors: Ning, Qin; Wu, Ting; Su, Hai-Bin; Ma, Ke; Qi, Jun-Ying; Ni, Ming; Wu, Di title: Antiviral Therapy for AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 journal: Acute Exacerbation of Chronic Hepatitis B DOI: 10.1007/978-94-024-1603-9_5 sha: doc_id: 32183 cord_uid: yqqqe325 file: cache/cord-034185-e0am7pa6.json key: cord-034185-e0am7pa6 authors: Piccioni, Federico; Droghetti, Andrea; Bertani, Alessandro; Coccia, Cecilia; Corcione, Antonio; Corsico, Angelo Guido; Crisci, Roberto; Curcio, Carlo; Del Naja, Carlo; Feltracco, Paolo; Fontana, Diego; Gonfiotti, Alessandro; Lopez, Camillo; Massullo, Domenico; Nosotti, Mario; Ragazzi, Riccardo; Rispoli, Marco; Romagnoli, Stefano; Scala, Raffaele; Scudeller, Luigia; Taurchini, Marco; Tognella, Silvia; Umari, Marzia; Valenza, Franco; Petrini, Flavia title: Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date: 2020-10-23 journal: Perioper Med (Lond) DOI: 10.1186/s13741-020-00159-z sha: doc_id: 34185 cord_uid: e0am7pa6 file: cache/cord-034435-yp0gfl47.json key: cord-034435-yp0gfl47 authors: Medetalibeyoglu, A.; Senkal, N.; Kose, M.; Catma, Y.; Caparali, E. Bilge; Erelel, M.; Oncul, M. Oral; Bahat, Gulistan; Tukek, T. title: Older Adults Hospitalized with Covid-19: Clinical Characteristics and Early Outcomes from a Single Center in Istanbul, Turkey date: 2020-10-08 journal: J Nutr Health Aging DOI: 10.1007/s12603-020-1499-9 sha: doc_id: 34435 cord_uid: yp0gfl47 file: cache/cord-034303-kcu9guxa.json key: cord-034303-kcu9guxa authors: Laimoud, Mohamed; Alanazi, Mosleh title: The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date: 2020-10-27 journal: Egypt Heart J DOI: 10.1186/s43044-020-00108-7 sha: doc_id: 34303 cord_uid: kcu9guxa file: cache/cord-034371-j3xxmkjd.json key: cord-034371-j3xxmkjd authors: Schellack, Natalie; Coetzee, Monique; Schellack, Gustav; Gijzelaar, Michelle; Hassim, Zeenat; Milne, Marnus; Bronkhorst, Elmien; Padayachee, Neelaveni; Singh, Nirasha; Kolman, Sonya; Gray, Andrew L. title: COVID-19: Guidelines for pharmacists in South Africa date: 2020-06-10 journal: S Afr J Infect Dis DOI: 10.4102/sajid.v35i1.206 sha: doc_id: 34371 cord_uid: j3xxmkjd file: cache/cord-034690-x8lkngra.json key: cord-034690-x8lkngra authors: Ridge, Carole A; Desai, Sujal R; Jeyin, Nidhish; Mahon, Ciara; Lother, Dione L; Mirsadraee, Saeed; Semple, Tom; Price, Susanna; Bleakley, Caroline; Arachchillage, Deepa J; Shaw, Elizabeth; Patel, Brijesh V; Padley, Simon PG; Devaraj, Anand title: Dual-Energy CT Pulmonary Angiography (DECTPA) Quantifies Vasculopathy in Severe COVID-19 Pneumonia date: 2020-10-29 journal: Radiol Cardiothorac Imaging DOI: 10.1148/ryct.2020200428 sha: doc_id: 34690 cord_uid: x8lkngra file: cache/cord-032244-s7t5u9lf.json key: cord-032244-s7t5u9lf authors: Valente, Serafina; Colivicchi, Furio; Caldarola, Pasquale; Murrone, Adriano; Di Lenarda, Andrea; Roncon, Loris; Amodeo, Enzo; Aspromonte, Nadia; Cipriani, Manlio Gianni; Domenicucci, Stefano; Francese, Giuseppina Maura; Imazio, Massimo; Scotto di Uccio, Fortunato; Urbinati, Stefano; Gulizia, Michele Massimo; Gabrielli, Domenico title: ANMCO POSITION PAPER: Considerations on in-hospital cardiological consultations and cardiology outpatient clinics during the COVID-19 pandemic date: 2020-08-27 journal: Eur Heart J Suppl DOI: 10.1093/eurheartj/suaa112 sha: doc_id: 32244 cord_uid: s7t5u9lf file: cache/cord-034340-3ksfpaf7.json key: cord-034340-3ksfpaf7 authors: nan title: Proceedings of the 26th European Paediatric Rheumatology Congress: part 2: Virtual. 23 - 26 September 2020 date: 2020-10-28 journal: Pediatr Rheumatol Online J DOI: 10.1186/s12969-020-00470-5 sha: doc_id: 34340 cord_uid: 3ksfpaf7 file: cache/cord-034746-uxhpufnv.json key: cord-034746-uxhpufnv authors: Nusshag, Christian; Stütz, Alisa; Hägele, Stefan; Speer, Claudius; Kälble, Florian; Eckert, Christoph; Brenner, Thorsten; Weigand, Markus A.; Morath, Christian; Reiser, Jochen; Zeier, Martin; Krautkrämer, Ellen title: Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date: 2020-11-05 journal: Sci Rep DOI: 10.1038/s41598-020-76050-0 sha: doc_id: 34746 cord_uid: uxhpufnv file: cache/cord-103686-er8llst4.json key: cord-103686-er8llst4 authors: Carboni Bisso, I.; Prado, E.; Cantos, J.; Masso, A.; Staneloni, I.; San Roman, E.; Huespe, I.; Las Heras, M. title: Influenza season 2019: analysis of 143 hospitalized cases date: 2020-09-18 journal: nan DOI: 10.1101/2020.09.16.20195974 sha: doc_id: 103686 cord_uid: er8llst4 file: cache/cord-034898-zjfhpum2.json key: cord-034898-zjfhpum2 authors: Patangi, Sanjay Orathi; Shetty, Riyan Sukumar; Shanmugasundaram, Balasubramanian; Kasturi, Srikanth; Raheja, Shivangi title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective date: 2020-11-07 journal: Indian J Thorac Cardiovasc Surg DOI: 10.1007/s12055-020-01051-7 sha: doc_id: 34898 cord_uid: zjfhpum2 file: cache/cord-035024-kx9jfssi.json key: cord-035024-kx9jfssi authors: Elmelhat, Ahmed; Elbourai, Essam; Dewedar, Hany; Elgergawi, Taghrid; Alkhanbouli, Maryam; Ahmed, Salwa; Malik, Zoiya; Nugud, Alaa; Mohammed, Shadha; Mohammad, Hozaifah; Husain, Abdullah title: Comparison between Prophylactic versus Therapeutic Doses of Low-Molecular-Weight Heparin in Severely Ill Coronavirus Disease 2019 Patients in Relation to Disease Progression and Outcome date: 2020-10-26 journal: nan DOI: 10.1159/000511163 sha: doc_id: 35024 cord_uid: kx9jfssi file: cache/cord-035067-ic843wr9.json key: cord-035067-ic843wr9 authors: de Almeida, Joana Ferro Machado; Chehter, Ethel Zimberg title: COVID-19 and the gastrointestinal tract: what do we already know? date: 2020-11-05 journal: nan DOI: 10.31744/einstein_journal/2020rw5909 sha: doc_id: 35067 cord_uid: ic843wr9 file: cache/cord-032181-gmcugd8h.json key: cord-032181-gmcugd8h authors: Song, Jian-Xin; Zhu, Lin; Zhu, Chuan-Long; Hu, Jin-Hua; Sun, Zi-Jian; Xu, Xiang; Xin, Min-You; Zhang, Qiong-Fang; Zhang, Da-Zhi; Shang, Jia; Huang, Jia-Quan; Xu, Dong title: Main Complications of AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 journal: Acute Exacerbation of Chronic Hepatitis B DOI: 10.1007/978-94-024-1603-9_2 sha: doc_id: 32181 cord_uid: gmcugd8h file: cache/cord-035030-ig4nwtmi.json key: cord-035030-ig4nwtmi authors: nan title: 10th European Conference on Rare Diseases & Orphan Products (ECRD 2020) date: 2020-11-09 journal: Orphanet J Rare Dis DOI: 10.1186/s13023-020-01550-1 sha: doc_id: 35030 cord_uid: ig4nwtmi file: cache/cord-048489-ajafw966.json key: cord-048489-ajafw966 authors: Bozza, Fernando A; Cruz, Oswaldo G; Zagne, Sonia MO; Azeredo, Elzinandes L; Nogueira, Rita MR; Assis, Edson F; Bozza, Patricia T; Kubelka, Claire F title: Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity date: 2008-06-25 journal: BMC Infect Dis DOI: 10.1186/1471-2334-8-86 sha: doc_id: 48489 cord_uid: ajafw966 file: cache/cord-034578-i9rdubix.json key: cord-034578-i9rdubix authors: Vaschetto, Rosanna; Barone-Adesi, Francesco; Racca, Fabrizio; Pissaia, Claudio; Maestrone, Carlo; Colombo, Davide; Olivieri, Carlo; De Vita, Nello; Santangelo, Erminio; Scotti, Lorenza; Castello, Luigi; Cena, Tiziana; Taverna, Martina; Grillenzoni, Luca; Moschella, Maria Adele; Airoldi, Gianluca; Borrè, Silvio; Mojoli, Francesco; Della Corte, Francesco; Navalesi, Paolo; Cammarota, Gianmaria; Baggiani, Marta; Baino, Sara; Balbo, Piero; Bazzano, Simona; Bonato, Valeria; Carbonati, Sara; Crimaldi, Federico; Daffara, Veronica; De Col, Luca; Maestrone, Matteo; Malerba, Mario; Moroni, Federica; Perucca, Raffaella; Pirisi, Mario; Rondi, Valentina; Rosalba, Daniela; Vanni, Letizia; Vigone, Francesca title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 journal: ERJ Open Res DOI: 10.1183/23120541.00541-2020 sha: doc_id: 34578 cord_uid: i9rdubix file: cache/cord-035026-2qcsfd87.json key: cord-035026-2qcsfd87 authors: Ugwueze, Chidiebere V.; Ezeokpo, Basil Chukwuma; Nnolim, Bede I.; Agim, Emmanuel A.; Anikpo, Nnamdi C.; Onyekachi, Kenechukwu E. title: COVID-19 and Diabetes Mellitus: The Link and Clinical Implications date: 2020-10-23 journal: nan DOI: 10.1159/000511354 sha: doc_id: 35026 cord_uid: 2qcsfd87 file: cache/cord-035316-l4qbiuuu.json key: cord-035316-l4qbiuuu authors: Dacie, Ruth; Woodhouse, Laura; Mullan, Damian; Lamarca, Angela title: Spontaneous Aortic Haematoma in a Patient Receiving Adjuvant Folinic Acid, 5-Fluorouracil, Irinotecan, and Oxaliplatin Chemotherapy Following Resection of a Pancreatic Adenocarcinoma date: 2020-10-12 journal: nan DOI: 10.7759/cureus.10908 sha: doc_id: 35316 cord_uid: l4qbiuuu file: cache/cord-035070-drt6esrk.json key: cord-035070-drt6esrk authors: Cheng, Yichun; Zhang, Nanhui; Luo, Ran; Zhang, Meng; Wang, Zhixiang; Dong, Lei; Li, Junhua; Zeng, Rui; Yao, Ying; Ge, Shuwang; Xu, Gang title: Risk Factors and Outcomes of Acute Kidney Injury in Critically Ill Patients with Coronavirus Disease 2019 date: 2020-10-26 journal: Kidney Dis (Basel) DOI: 10.1159/000512270 sha: doc_id: 35070 cord_uid: drt6esrk file: cache/cord-104055-47ren7ie.json key: cord-104055-47ren7ie authors: Lutkenhoff, Evan S.; Nigri, Anna; Sebastiano, Davide Rossi; Sattin, Davide; Visani, Elisa; Rosazza, Cristina; D’Incerti, Ludovico; Bruzzone, Maria Grazia; Franceschetti, Silvana; Leonardi, Matilde; Ferraro, Stefania; Monti, Martin M. title: EEG power spectra and subcortical pathology in chronic disorders of consciousness date: 2020-09-01 journal: bioRxiv DOI: 10.1101/695288 sha: doc_id: 104055 cord_uid: 47ren7ie file: cache/cord-035090-gnfeyddv.json key: cord-035090-gnfeyddv authors: Su, Qi; Xie, Zhong-Xiang; He, Feng; Liu, Zhen-Chuan; Song, Xiao-Jie; Zhao, Fu-Chun; Li, Dibin; Che, Feng-Yuan title: Adults with severe Japanese encephalitis: a retrospective analysis of 9 cases in Linyi, China date: 2020-11-09 journal: Neurol Sci DOI: 10.1007/s10072-020-04867-8 sha: doc_id: 35090 cord_uid: gnfeyddv file: cache/cord-102199-mc6zruyx.json key: cord-102199-mc6zruyx authors: Toksvang, Linea Natalie; Schmidt, Magnus Strøh; Arup, Sofie; Larsen, Rikke Hebo; Frandsen, Thomas Leth; Schmiegelow, Kjeld; Rank, Cecilie Utke title: Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: a systematic review date: 2019-01-30 journal: bioRxiv DOI: 10.1101/535518 sha: doc_id: 102199 cord_uid: mc6zruyx file: cache/cord-103214-3lz33pj3.json key: cord-103214-3lz33pj3 authors: Kortuem, S. O.; Becker, D.; Ott, H.-J.; Schlaudt, H.-P. title: The Role of the Emergency Department in Protecting the Hospital as a Critical Infrastructure in the Corona Pandemic Strategies and Experiences of a Rural Sole Acute-Care Clinic date: 2020-09-09 journal: nan DOI: 10.1101/2020.09.07.20185819 sha: doc_id: 103214 cord_uid: 3lz33pj3 file: cache/cord-048343-nzk8m912.json key: cord-048343-nzk8m912 authors: Milbrandt, Eric B; Angus, Derek C title: Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics date: 2006-11-15 journal: Crit Care DOI: 10.1186/cc5078 sha: doc_id: 48343 cord_uid: nzk8m912 file: cache/cord-102276-0a8hup5y.json key: cord-102276-0a8hup5y authors: Savage, R. S.; Messenger, M.; Neal, R. D.; Ferguson, R.; Johnston, C.; Lloyd, K. L.; Neal, M. D.; Sansom, N.; Selby, P.; Sharma, N.; Shinkins, B.; Skinner, J. R.; Tully, G.; Duffy, S.; Hall, G. title: Development and validation of multivariable machine learning algorithms to predict risk of cancer in symptomatic patients referred urgently from primary care date: 2020-10-27 journal: nan DOI: 10.1101/2020.10.23.20218198 sha: doc_id: 102276 cord_uid: 0a8hup5y file: cache/cord-104180-f3hoz9bu.json key: cord-104180-f3hoz9bu authors: Kirk-Bayley, Justin; Venn, Richard title: Recently published papers: inflammation, elucidation, manipulation? date: 2003-07-03 journal: Crit Care DOI: nan sha: doc_id: 104180 cord_uid: f3hoz9bu file: cache/cord-035182-ax6v3ak5.json key: cord-035182-ax6v3ak5 authors: Griebenow, Reinhard; Mills, Peter; Stein, Jörg; Herrmann, Henrik; Kelm, Malte; Campbell, Craig; Schäfer, Robert title: Outcomes in CME/CPD - Special Collection: How to make the “pyramid” a perpetuum mobile date: 2020-10-27 journal: nan DOI: 10.1080/21614083.2020.1832750 sha: doc_id: 35182 cord_uid: ax6v3ak5 file: cache/cord-104507-xx7t26rl.json key: cord-104507-xx7t26rl authors: Safari, Saeid; Salimi, Alireza; Zali, Alireza; Jahangirifard, Alireza; Bastanhagh, Ehsan; Aminnejad, Reza; Dabbagh, Ali; Lotfi, Amir Hossein; Saeidi, Mohammad title: Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Severe COVID-19 patients; a Narrative Review date: 2020-08-22 journal: Arch Acad Emerg Med DOI: nan sha: doc_id: 104507 cord_uid: xx7t26rl file: cache/cord-035315-j5mknuv5.json key: cord-035315-j5mknuv5 authors: Rahim, Fawad; Amin, Said; Noor, Mohammad; Bahadur, Sher; Gul, Huma; Mahmood, Afsheen; Usman, Muhammad; Khan, Muhammad Asif; Ullah, Raza; Shahab, Khalid title: Mortality of Patients With Severe COVID-19 in the Intensive Care Unit: An Observational Study From a Major COVID-19 Receiving Hospital date: 2020-10-12 journal: nan DOI: 10.7759/cureus.10906 sha: doc_id: 35315 cord_uid: j5mknuv5 file: cache/cord-184194-zdxebonv.json key: cord-184194-zdxebonv authors: Chen, Lichin; Tsao, Yu; Sheu, Ji-Tian title: Using Deep Learning and Explainable Artificial Intelligence in Patients' Choices of Hospital Levels date: 2020-06-24 journal: nan DOI: nan sha: doc_id: 184194 cord_uid: zdxebonv file: cache/cord-103807-x4hrwhkz.json key: cord-103807-x4hrwhkz authors: Prokop, J. W. title: Viral Induced Genetics Revealed by Multi-Dimensional Precision Medicine Transcriptional Workflow date: 2020-04-06 journal: nan DOI: 10.1101/2020.04.01.20050054 sha: doc_id: 103807 cord_uid: x4hrwhkz file: cache/cord-214006-0w6bqrox.json key: cord-214006-0w6bqrox authors: Aghdam, Atae Rezaei; Watson, Jason; Miah, Shah J; Cliff, Cynthia title: Towards Empowering Diabetic Patients: A perspective on self-management in the context of a group-based education program date: 2020-10-26 journal: nan DOI: nan sha: doc_id: 214006 cord_uid: 0w6bqrox file: cache/cord-217201-lvefk7qx.json key: cord-217201-lvefk7qx authors: Wang, Yang; Zhang, Fengwei; Yu, Hong; Ye, Xianwei; He, Yongqun title: Ontology-based annotation and analysis of COVID-19 phenotypes date: 2020-08-05 journal: nan DOI: nan sha: doc_id: 217201 cord_uid: lvefk7qx file: cache/cord-035396-lg7m9xzs.json key: cord-035396-lg7m9xzs authors: Bains, Amarpreet S.; Wang, Erwin; Duran, Deserie; Lee-Riley, Lorna; Volpicelli, Frank title: Maintaining Throughput and Reducing Discharge Delays After Increasing Capacity During The Covid-19 Pandemic: A New York City Hospital’s Experience date: 2020-11-12 journal: NEJM Catal Innov Care Deliv DOI: 10.1056/cat.20.0425 sha: doc_id: 35396 cord_uid: lg7m9xzs file: cache/cord-104467-elwfz1gk.json key: cord-104467-elwfz1gk authors: Kariyanna, Pramod Theetha; Sutarjono, Bayu; Grewal, Ekjot; Singh, Kamal Preet; Aurora, Lyudmila; Smith, Leanna; Chandrakumar, Harshith Priyan; Jayarangaiah, Apoorva; Goldman, Sarah A.; Salifu, Moro O.; McFarlane, Isabel M. title: A Systematic Review of COVID-19 and Myocarditis date: 2020-06-05 journal: Am J Med Case Rep DOI: nan sha: doc_id: 104467 cord_uid: elwfz1gk file: cache/cord-148109-ql1tthyr.json key: cord-148109-ql1tthyr authors: El-Din, Doaa Mohey; Hassanein, Aboul Ella; Hassanien, Ehab E.; Hussein, Walaa M.E. title: E-Quarantine: A Smart Health System for Monitoring Coronavirus Patients for Remotely Quarantine date: 2020-05-05 journal: nan DOI: nan sha: doc_id: 148109 cord_uid: ql1tthyr file: cache/cord-244388-dxrrpxl7.json key: cord-244388-dxrrpxl7 authors: Marchiori, Chiara; Dykeman, Douglas; Girardi, Ivan; Ivankay, Adam; Thandiackal, Kevin; Zusag, Mario; Giovannini, Andrea; Karpati, Daniel; Saenz, Henri title: Artificial Intelligence Decision Support for Medical Triage date: 2020-11-09 journal: nan DOI: nan sha: doc_id: 244388 cord_uid: dxrrpxl7 file: cache/cord-158252-l43ztxsl.json key: cord-158252-l43ztxsl authors: Pawlowski, Colin; Wagner, Tyler; Puranik, Arjun; Murugadoss, Karthik; Loscalzo, Liam; Venkatakrishnan, AJ; Pruthi, Rajiv K.; Houghton, Damon E.; OHoro, John C.; Morice, William G.; Halamka, John; Badley, Andrew D.; Barnathan, Elliot S.; Makimura, Hideo; Khan, Najat; Soundararajan, Venky title: Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures date: 2020-05-21 journal: nan DOI: nan sha: doc_id: 158252 cord_uid: l43ztxsl file: cache/cord-204125-fvd6d44c.json key: cord-204125-fvd6d44c authors: Chowdhury, Muhammad E. H.; Rahman, Tawsifur; Khandakar, Amith; Al-Madeed, Somaya; Zughaier, Susu M.; Doi, Suhail A. R.; Hassen, Hanadi; Islam, Mohammad T. title: An early warning tool for predicting mortality risk of COVID-19 patients using machine learning date: 2020-07-29 journal: nan DOI: nan sha: doc_id: 204125 cord_uid: fvd6d44c file: cache/cord-216974-0al3vdh1.json key: cord-216974-0al3vdh1 authors: Ravaud, Philippe; Ouay, Franck le; Depaulis, Etienne; Huckert, Alexandre; Vegreville, Bruno; Tran, Viet-Thi title: Reconfiguring health services to reduce the workload of caregivers during the COVID-19 outbreak using an open-source scalable platform for remote digital monitoring and coordination of care in hospital Command Centres date: 2020-03-12 journal: nan DOI: nan sha: doc_id: 216974 cord_uid: 0al3vdh1 file: cache/cord-103659-wpwfqhp2.json key: cord-103659-wpwfqhp2 authors: Almqvist, J.; Granberg, T.; Tzortzakakis, A.; Klironomos, S.; Kollia, E.; Oehberg, C.; Martin, R.; Piehl, F.; Ouellette, R.; Ineichen, B. V. title: Neurological manifestations of coronavirus infections: a systematic review date: 2020-09-01 journal: nan DOI: 10.1101/2020.08.26.20182196 sha: doc_id: 103659 cord_uid: wpwfqhp2 file: cache/cord-252159-6t35bxwv.json key: cord-252159-6t35bxwv authors: Ferraù, F.; Ceccato, F.; Cannavò, S.; Scaroni, C. title: What we have to know about corticosteroids use during Sars-Cov-2 infection date: 2020-08-28 journal: J Endocrinol Invest DOI: 10.1007/s40618-020-01384-5 sha: doc_id: 252159 cord_uid: 6t35bxwv file: cache/cord-252617-rqm0p19e.json key: cord-252617-rqm0p19e authors: Baker, Paul A.; Peyton, James; von Ungern‐Sternberg, Britta S. title: What’s inside the box? Or shall we think outside the box? date: 2020-08-28 journal: Paediatr Anaesth DOI: 10.1111/pan.13932 sha: doc_id: 252617 cord_uid: rqm0p19e file: cache/cord-138439-wvynetna.json key: cord-138439-wvynetna authors: Wei, Xiyi; Xiao, Yu-Tian; Wang, Jian; Chen, Rui; Zhang, Wei; Yang, Yue; Lv, Daojun; Qin, Chao; Gu, Di; Zhang, Bo; Chen, Weidong; Hou, Jianquan; Song, Ninghong; Zeng, Guohua; Ren, Shancheng title: Sex Differences in Severity and Mortality Among Patients With COVID-19: Evidence from Pooled Literature Analysis and Insights from Integrated Bioinformatic Analysis date: 2020-03-30 journal: nan DOI: nan sha: doc_id: 138439 cord_uid: wvynetna file: cache/cord-252829-gn56tsz3.json key: cord-252829-gn56tsz3 authors: Higginson, Irene J.; Yi, Deokhee; Johnston, Bridget M.; Ryan, Karen; McQuillan, Regina; Selman, Lucy; Pantilat, Stephen Z.; Daveson, Barbara A.; Morrison, R. Sean; Normand, Charles title: Associations between informal care costs, care quality, carer rewards, burden and subsequent grief: the international, access, rights and empowerment mortality follow-back study of the last 3 months of life (IARE I study) date: 2020-11-03 journal: BMC Med DOI: 10.1186/s12916-020-01768-7 sha: doc_id: 252829 cord_uid: gn56tsz3 file: cache/cord-252473-i4pmux28.json key: cord-252473-i4pmux28 authors: Rogers, Sharon title: Why can't I visit? The ethics of visitation restrictions – lessons learned from SARS date: 2004-08-31 journal: Crit Care DOI: 10.1186/cc2930 sha: doc_id: 252473 cord_uid: i4pmux28 file: cache/cord-252374-obl6pfpf.json key: cord-252374-obl6pfpf authors: Zaninotto, Martina; Maria Mion, Monica; Padoan, Andrea; Babuin, Luciano; Plebani, Mario title: Cardiac troponin I in SARS-CoV-2-patients: the additional prognostic value of serial monitoring date: 2020-10-01 journal: Clin Chim Acta DOI: 10.1016/j.cca.2020.09.036 sha: doc_id: 252374 cord_uid: obl6pfpf file: cache/cord-251957-luw8m3eq.json key: cord-251957-luw8m3eq authors: Griffin, Claire L.; Sharma, Vikas; Sarfati, Mark R.; Smith, Brigitte K.; Kraiss, Larry W.; McKellar, Stephen H.; Koliopoulou, Antigone; Brooke, Benjamin S.; Selzman, Craig H.; Glotzbach, Jason P. title: Aortic Disease in the Time of COVID: Repercussions on Patient Care at an Academic Aortic Center date: 2020-04-30 journal: J Vasc Surg DOI: 10.1016/j.jvs.2020.04.487 sha: doc_id: 251957 cord_uid: luw8m3eq file: cache/cord-252013-ehyuflg3.json key: cord-252013-ehyuflg3 authors: Bozzani, Antonio; Arici, Vittorio; Tavazzi, Guido; Franciscone, Mila Maria; Danesino, Vittorio; Rota, Monica; Rossini, Rosa; Sterpetti, Antonio V.; Ticozzelli, Giulia; Rumi, Elisa; Mojoli, Francesco; Bruno, Raffaele; Ragni, Franco title: ACUTE ARTERIAL AND DEEP VENOUS THROMBOEMBOLISM IN COVID-19 PATIENTS date: 2020-09-22 journal: Surgery DOI: 10.1016/j.surg.2020.09.009 sha: doc_id: 252013 cord_uid: ehyuflg3 file: cache/cord-252368-njlo6g78.json key: cord-252368-njlo6g78 authors: Prasad, Aman; Brewster, Ryan; Newman, Jason G.; Rajasekaran, Karthik title: Optimizing your telemedicine visit during the COVID‐19 pandemic: Practice guidelines for patients with head and neck cancer date: 2020-04-28 journal: Head Neck DOI: 10.1002/hed.26197 sha: doc_id: 252368 cord_uid: njlo6g78 file: cache/cord-252506-8u9oiqoc.json key: cord-252506-8u9oiqoc authors: Scarfò, Lydia; Chatzikonstantinou, Thomas; Rigolin, Gian Matteo; Quaresmini, Giulia; Motta, Marina; Vitale, Candida; Garcia-Marco, Jose Antonio; Hernández-Rivas, José Ángel; Mirás, Fatima; Baile, Mónica; Marquet, Juan; Niemann, Carsten U.; Reda, Gianluigi; Munir, Talha; Gimeno, Eva; Marchetti, Monia; Quaglia, Francesca Maria; Varettoni, Marzia; Delgado, Julio; Iyengar, Sunil; Janssens, Ann; Marasca, Roberto; Ferrari, Angela; Cuéllar-García, Carolina; Itchaki, Gilad; Špaček, Martin; De Paoli, Lorenzo; Laurenti, Luca; Levin, Mark-David; Lista, Enrico; Mauro, Francesca R.; Šimkovič, Martin; Van Der Spek, Ellen; Vandenberghe, Elisabeth; Trentin, Livio; Wasik-Szczepanek, Ewa; Ruchlemer, Rosa; Bron, Dominique; De Paolis, Maria Rosaria; Del Poeta, Giovanni; Farina, Lucia; Foglietta, Myriam; Gentile, Massimo; Herishanu, Yair; Herold, Tobias; Jaksic, Ozren; Kater, Arnon P.; Kersting, Sabina; Malerba, Lara; Orsucci, Lorella; Popov, Viola Maria; Sportoletti, Paolo; Yassin, Mohamed; Pocali, Barbara; Barna, Gabor; Chiarenza, Annalisa; dos Santos, Gimena; Nikitin, Eugene; Andres, Martin; Dimou, Maria; Doubek, Michael; Enrico, Alicia; Hakobyan, Yervand; Kalashnikova, Olga; Ortiz Pareja, Macarena; Papaioannou, Maria; Rossi, Davide; Shah, Nimish; Shrestha, Amit; Stanca, Oana; Stavroyianni, Niki; Strugov, Vladimir; Tam, Constantine; Zdrenghea, Mihnea; Coscia, Marta; Stamatopoulos, Kostas; Rossi, Giuseppe; Rambaldi, Alessandro; Montserrat, Emili’; Foà, Robin; Cuneo, Antonio; Ghia, Paolo title: COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus date: 2020-07-09 journal: Leukemia DOI: 10.1038/s41375-020-0959-x sha: doc_id: 252506 cord_uid: 8u9oiqoc file: cache/cord-252279-0gozdv43.json key: cord-252279-0gozdv43 authors: Pal, Amit; Pawar, Anil; Goswami, Kalyan; Sharma, Praveen; Prasad, Rajendra title: Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update date: 2020-06-10 journal: Indian J Clin Biochem DOI: 10.1007/s12291-020-00900-x sha: doc_id: 252279 cord_uid: 0gozdv43 file: cache/cord-252539-kx8ew3ap.json key: cord-252539-kx8ew3ap authors: Riera, Jordi; Argudo, Eduard; Martínez-Martínez, María; García, Sandra; García-de-Acilu, Marina; Santafé, Manel; Díaz, Cándido; Contreras, Sofía; Cortina, Alexandra; Bonilla, Camilo; Pacheco, Andrés; Resta, Paula; Palmer, Neiser; Castro, Miguel Ángel; Ferrer, Ricard title: Extracorporeal Membrane Oxygenation Retrieval in Coronavirus Disease 2019: A Case-Series of 19 Patients Supported at a High-Volume Extracorporeal Membrane Oxygenation Center date: 2020-09-28 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000228 sha: doc_id: 252539 cord_uid: kx8ew3ap file: cache/cord-252284-cgdcsazr.json key: cord-252284-cgdcsazr authors: Zeng, Jia-Hui; Liu, Ying-Xia; Yuan, Jing; Wang, Fu-Xiang; Wu, Wei-Bo; Li, Jin-Xiu; Wang, Li-Fei; Gao, Hong; Wang, Yao; Dong, Chang-Feng; Li, Yi-Jun; Xie, Xiao-Juan; Feng, Cheng; Liu, Lei title: First case of COVID-19 complicated with fulminant myocarditis: a case report and insights date: 2020-04-10 journal: Infection DOI: 10.1007/s15010-020-01424-5 sha: doc_id: 252284 cord_uid: cgdcsazr file: cache/cord-252288-klkoerfn.json key: cord-252288-klkoerfn authors: Zhang, Bicheng; Zhou, Xiaoyang; Zhu, Chengliang; Song, Yuxiao; Feng, Fan; Qiu, Yanru; Feng, Jia; Jia, Qingzhu; Song, Qibin; Zhu, Bo; Wang, Jun title: Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19 date: 2020-07-03 journal: Front Mol Biosci DOI: 10.3389/fmolb.2020.00157 sha: doc_id: 252288 cord_uid: klkoerfn file: cache/cord-252101-77lnyjan.json key: cord-252101-77lnyjan authors: Mathanlal, Thasshwin; Israel Nazarious, Miracle; Mantas-Nakhai, Roberto; Zorzano, Maria-Paz; Martin-Torres, Javier title: ATMO-Vent: an adapted breathing atmosphere for COVID-19 patients date: 2020-09-26 journal: HardwareX DOI: 10.1016/j.ohx.2020.e00145 sha: doc_id: 252101 cord_uid: 77lnyjan file: cache/cord-252060-cotsu82v.json key: cord-252060-cotsu82v authors: Pericleous, Stephanos; Bhogal, Ricky H. title: Coronavirus Disease 2019 Pandemic: Potential Collateral Damage on Patients With Operable Pancreatic Cancer date: 2020-06-23 journal: Pancreas DOI: 10.1097/mpa.0000000000001594 sha: doc_id: 252060 cord_uid: cotsu82v file: cache/cord-252687-7084pfqm.json key: cord-252687-7084pfqm authors: Szelenberger, Rafal; Saluk-Bijak, Joanna; Bijak, Michal title: Ischemic Stroke among the Symptoms Caused by the COVID-19 Infection date: 2020-08-19 journal: J Clin Med DOI: 10.3390/jcm9092688 sha: doc_id: 252687 cord_uid: 7084pfqm file: cache/cord-225218-x32a4sp3.json key: cord-225218-x32a4sp3 authors: Filntisis, Panagiotis P.; Zlatintsi, Athanasia; Efthymiou, Niki; Kalisperakis, Emmanouil; Karantinos, Thomas; Lazaridi, Marina; Smyrnis, Nikolaos; Maragos, Petros title: Identifying differences in physical activity and autonomic function patterns between psychotic patients and controls over a long period of continuous monitoring using wearable sensors date: 2020-10-30 journal: nan DOI: nan sha: doc_id: 225218 cord_uid: x32a4sp3 file: cache/cord-104404-ytszpa4c.json key: cord-104404-ytszpa4c authors: Baig, Muhammad Akbar title: The COVID-19 Intubation and Ventilation Pathway (CiVP); a Commentary date: 2020-03-25 journal: Arch Acad Emerg Med DOI: nan sha: doc_id: 104404 cord_uid: ytszpa4c file: cache/cord-252452-wwkw1uyi.json key: cord-252452-wwkw1uyi authors: Rossi, Rosario; Talarico, Marisa; Coppi, Francesca; Boriani, Giuseppe title: Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action date: 2020-10-03 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02504-y sha: doc_id: 252452 cord_uid: wwkw1uyi file: cache/cord-252085-8dq3gdo8.json key: cord-252085-8dq3gdo8 authors: Kaisy, Dr. Maythem Abdulhassan Al title: Chest Drain Insertion following Pneumothorax due to CPR in a COVID – 19 Patient. date: 2020-08-14 journal: Visual Journal of Emergency Medicine DOI: 10.1016/j.visj.2020.100862 sha: doc_id: 252085 cord_uid: 8dq3gdo8 file: cache/cord-252531-i3b647wv.json key: cord-252531-i3b647wv authors: Song, Zaiwei; Hu, Yang; Zheng, Siqian; Yang, Li; Zhao, Rongsheng title: Hospital pharmacists’ pharmaceutical care for hospitalized patients with COVID-19: Recommendations and guidance from clinical experience date: 2020-04-03 journal: Res Social Adm Pharm DOI: 10.1016/j.sapharm.2020.03.027 sha: doc_id: 252531 cord_uid: i3b647wv file: cache/cord-253168-b095rq5i.json key: cord-253168-b095rq5i authors: Jiménez-Blanco Bravo, Marta; Cordero Pereda, David; Sánchez Vega, Diego; del Prado Díaz, Susana; Monteagudo Ruiz, Juan Manuel; Zamorano Gómez, José Luis; Alonso Salinas, Gonzalo Luis title: Heart Failure in the Time of COVID-19 date: 2020-06-26 journal: Cardiology DOI: 10.1159/000509181 sha: doc_id: 253168 cord_uid: b095rq5i file: cache/cord-252243-ua2w6xki.json key: cord-252243-ua2w6xki authors: Cooper, Emily; Jones, Leah; Joseph, Annie; Allison, Rosie; Gold, Natalie; Larcombe, James; Moore, Philippa; McNulty, Cliodna A. M. title: Diagnosis and Management of UTI in Primary Care Settings—A Qualitative Study to Inform a Diagnostic Quick Reference Tool for Women Under 65 Years date: 2020-09-07 journal: Antibiotics (Basel) DOI: 10.3390/antibiotics9090581 sha: doc_id: 252243 cord_uid: ua2w6xki file: cache/cord-253148-3t4o27xp.json key: cord-253148-3t4o27xp authors: Chow, Brian D.W.; Huang, Yung T.; Esper, Frank P. title: Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio date: 2008-09-19 journal: J Clin Virol DOI: 10.1016/j.jcv.2008.07.009 sha: doc_id: 253148 cord_uid: 3t4o27xp file: cache/cord-252699-0xw9xvox.json key: cord-252699-0xw9xvox authors: de Marcaida, Joy Antonelle; Lahrmann, Jeffrey; Machado, Duarte; Bluth, Lawrence; Dagostine, Michelle; Moro-de Casillas, Maria; Bortan, Elena; Kanchana, Sulada; Alberts, Mark title: Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) among Patients at a Movement Disorders Center date: 2020-09-18 journal: Geriatrics (Basel) DOI: 10.3390/geriatrics5030054 sha: doc_id: 252699 cord_uid: 0xw9xvox file: cache/cord-252751-prock3co.json key: cord-252751-prock3co authors: Kalligeros, Markos; Tashima, Karen T; Mylona, Evangelia K; Rybak, Natasha; Flanigan, Timothy P; Farmakiotis, Dimitrios; Beckwith, Curt G; Sanchez, Martha; Neill, Marguerite; Johnson, Jennie E; Garland, Joseph M; Aung, Su; Byrd, Katrina M; O’Brien, Thomas; Pandita, Aakriti; Aridi, Jad; Macias Gil, Raul; Larkin, Jerome; Shehadeh, Fadi; Mylonakis, Eleftherios title: Remdesivir Use Compared to Supportive Care in Hospitalized Patients with Severe COVID-19: A Single-Center Experience date: 2020-08-06 journal: Open Forum Infect Dis DOI: 10.1093/ofid/ofaa319 sha: doc_id: 252751 cord_uid: prock3co file: cache/cord-253456-u9num2o9.json key: cord-253456-u9num2o9 authors: Zhang, Che; Gu, Jiaowei; Chen, Quanjing; Deng, Na; Li, Jingfeng; Huang, Li; Zhou, Xihui title: Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series date: 2020-06-16 journal: PLoS Med DOI: 10.1371/journal.pmed.1003130 sha: doc_id: 253456 cord_uid: u9num2o9 file: cache/cord-254148-wc762p6v.json key: cord-254148-wc762p6v authors: Prell, Tino; Siebecker, Frank; Lorrain, Michael; Eggers, Carsten; Lorenzl, Stefan; Klucken, Jochen; Warnecke, Tobias; Buhmann, Carsten; Tönges, Lars; Ehret, Reinhard; Wellach, Ingmar; Wolz, Martin title: Recommendations for Standards of Network Care for Patients with Parkinson’s Disease in Germany date: 2020-05-13 journal: J Clin Med DOI: 10.3390/jcm9051455 sha: doc_id: 254148 cord_uid: wc762p6v file: cache/cord-252890-of29g89s.json key: cord-252890-of29g89s authors: Villarreal-Fernandez, Eduardo; Patel, Ravi; Golamari, Reshma; Khalid, Muhammad; DeWaters, Ami; Haouzi, Philippe title: A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure date: 2020-06-12 journal: Crit Care DOI: 10.1186/s13054-020-03063-6 sha: doc_id: 252890 cord_uid: of29g89s file: cache/cord-252981-hywvmdjb.json key: cord-252981-hywvmdjb authors: Lockey, Stephen D. title: What’s Important: What Is Our Role in the COVID-19 Pandemic? date: 2020-04-10 journal: J Bone Joint Surg Am DOI: 10.2106/jbjs.20.00444 sha: doc_id: 252981 cord_uid: hywvmdjb file: cache/cord-253886-4b3i30hi.json key: cord-253886-4b3i30hi authors: Isakov, Alexander; Miles, Wade; Gibbs, Shawn; Lowe, John; Jamison, Aaron; Swansiger, Raymond title: Transport and Management of Patients With Confirmed or Suspected Ebola Virus Disease date: 2015-05-21 journal: Ann Emerg Med DOI: 10.1016/j.annemergmed.2015.04.008 sha: doc_id: 253886 cord_uid: 4b3i30hi file: cache/cord-253256-909chgl0.json key: cord-253256-909chgl0 authors: Bajwa, Sukhminder Jit Singh; Sarna, Rashi; Bawa, Chashamjot; Mehdiratta, Lalit title: Peri-operative and critical care concerns in coronavirus pandemic date: 2020-03-28 journal: Indian J Anaesth DOI: 10.4103/ija.ija_272_20 sha: doc_id: 253256 cord_uid: 909chgl0 file: cache/cord-253638-5f9ofdsc.json key: cord-253638-5f9ofdsc authors: Alsaied, Tarek; Aboulhosn, Jamil A.; Cotts, Timothy B.; Daniels, Curt J.; Etheridge, Susan P.; Feltes, Timothy F.; Gurvitz, Michelle Z.; Lewin, Mark B.; Oster, Matthew E.; Saidi, Arwa title: Coronavirus Disease 2019 (COVID‐19) Pandemic Implications in Pediatric and Adult Congenital Heart Disease date: 2020-06-10 journal: J Am Heart Assoc DOI: 10.1161/jaha.120.017224 sha: doc_id: 253638 cord_uid: 5f9ofdsc file: cache/cord-253129-v5lck9l7.json key: cord-253129-v5lck9l7 authors: Kim, Kyeong Tae; Morton, Sophie; Howe, Sarah; Chiew, Yeong Shiong; Knopp, Jennifer L.; Docherty, Paul; Pretty, Christopher; Desaive, Thomas; Benyo, Balazs; Szlavecz, Akos; Moeller, Knut; Shaw, Geoffrey M.; Chase, J. Geoffrey title: Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial date: 2020-02-01 journal: Trials DOI: 10.1186/s13063-019-4035-7 sha: doc_id: 253129 cord_uid: v5lck9l7 file: cache/cord-254269-x8vpnhd2.json key: cord-254269-x8vpnhd2 authors: Hakim, Abraham A.; Kellish, Alec S.; Atabek, Umur; Spitz, Francis R.; Hong, Young K. title: Implications for the use of telehealth in surgical patients during the COVID-19 pandemic date: 2020-04-21 journal: Am J Surg DOI: 10.1016/j.amjsurg.2020.04.026 sha: doc_id: 254269 cord_uid: x8vpnhd2 file: cache/cord-253417-ihi67m1u.json key: cord-253417-ihi67m1u authors: Paleri, Vinidh; Hardman, John; Tikka, Theofano; Bradley, Paula; Pracy, Paul; Kerawala, Cyrus title: Rapid implementation of an evidence‐based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow‐up after treatment during the COVID‐19 pandemic: Model for international collaboration date: 2020-05-11 journal: Head Neck DOI: 10.1002/hed.26219 sha: doc_id: 253417 cord_uid: ihi67m1u file: cache/cord-253375-m3qjj7r4.json key: cord-253375-m3qjj7r4 authors: Perini, Guilherme Fleury; Fischer, Thais; Gaiolla, Rafael Dezen; Rocha, Talita Bueno; Bellesso, Marcelo; Teixeira, Larissa Lane Cardoso; Delamain, Marcia Torresan; Scheliga, Adriana Alves de Souza; Ribeiro, Glaciano Nogueira; Neto, Jorge Vaz; Baiocchi, Otávio Cesar Carvalho Guimaraes; Abdo, André Neder Ramires; Arrais-Rodrigues, Celso; Fogliatto, Laura M.; Bigni, Ricardo de Sá; Schaffel, Rony; Biasoli, Irene; Pereira, Juliana; Nablan, Samir Kanaan; Souza, Cármino Antônio de; Chiattone, Carlos Sérgio title: How to manage lymphoid malignancies during novel 2019 coronavirus (CoVid-19) outbreak: a Brazilian task force recommendation date: 2020-04-17 journal: Hematol Transfus Cell Ther DOI: 10.1016/j.htct.2020.04.002 sha: doc_id: 253375 cord_uid: m3qjj7r4 file: cache/cord-253077-61fmul8c.json key: cord-253077-61fmul8c authors: Vabret, Nicolas; Britton, Graham J.; Gruber, Conor; Hegde, Samarth; Kim, Joel; Kuksin, Maria; Levantovsky, Rachel; Malle, Louise; Moreira, Alvaro; Park, Matthew D.; Pia, Luisanna; Risson, Emma; Saffern, Miriam; Salomé, Bérengère; Selvan, Myvizhi Esai; Spindler, Matthew P.; Tan, Jessica; van der Heide, Verena; Gregory, Jill K.; Alexandropoulos, Konstantina; Bhardwaj, Nina; Brown, Brian D.; Greenbaum, Benjamin; Gümüş, Zeynep H.; Homann, Dirk; Horowitz, Amir; Kamphorst, Alice O.; Curotto de Lafaille, Maria A.; Mehandru, Saurabh; Merad, Miriam; Samstein, Robert M. title: Immunology of COVID-19: current state of the science date: 2020-05-06 journal: Immunity DOI: 10.1016/j.immuni.2020.05.002 sha: doc_id: 253077 cord_uid: 61fmul8c file: cache/cord-254072-evgw0as5.json key: cord-254072-evgw0as5 authors: Hsu, Li-Yang; Lee, Cheng-Chuan; Green, Justin A.; Ang, Brenda; Paton, Nicholas I.; Lee, Lawrence; Villacian, Jorge S.; Lim, Poh-Lian; Earnest, Arul; Leo, Yee-Sin title: Severe Acute Respiratory Syndrome (SARS) in Singapore: Clinical Features of Index Patient and Initial Contacts date: 2003-06-17 journal: Emerg Infect Dis DOI: 10.3201/eid0906.030264 sha: doc_id: 254072 cord_uid: evgw0as5 file: cache/cord-253189-uba6dy08.json key: cord-253189-uba6dy08 authors: Walker, Katie; Heaton, Heather A. title: The evidence base for scribes and the disruptions of COVID-19 date: 2020-09-21 journal: Ann Emerg Med DOI: 10.1016/j.annemergmed.2020.09.438 sha: doc_id: 253189 cord_uid: uba6dy08 file: cache/cord-253862-jl1zhg13.json key: cord-253862-jl1zhg13 authors: Khalaf, Khalil; Papp, Natalia; Chou, Jadzia Tin-Tsen; Hana, Doris; Mackiewicz, Andrzej; Kaczmarek, Mariusz title: SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment date: 2020-10-06 journal: Front Immunol DOI: 10.3389/fimmu.2020.570927 sha: doc_id: 253862 cord_uid: jl1zhg13 file: cache/cord-253962-ug7yflxh.json key: cord-253962-ug7yflxh authors: Huang, Dong; Wang, Ting; Chen, Zhu; Yang, Huan; Yao, Rong; Liang, Zongan title: A novel risk score to predict diagnosis with Coronavirus Disease 2019 (COVID‐19) in suspected patients: A retrospective, multi‐center, observational study date: 2020-06-08 journal: J Med Virol DOI: 10.1002/jmv.26143 sha: doc_id: 253962 cord_uid: ug7yflxh file: cache/cord-252775-faxiem2w.json key: cord-252775-faxiem2w authors: Tamagnini, Gabriele; Biondi, Raoul; Ricciardi, Gabriella; Rutigliano, Roberta; Trias‐Llimós, Sergi; Meuris, Bart; Lamelas, Joseph; Del Giglio, Mauro title: Cardiac surgery in the time of the novel coronavirus: Why we should think to a new normal date: 2020-07-15 journal: J Card Surg DOI: 10.1111/jocs.14741 sha: doc_id: 252775 cord_uid: faxiem2w file: cache/cord-253704-y0t30xw3.json key: cord-253704-y0t30xw3 authors: Lahiri, Durjoy; Ardila, Alfredo title: COVID-19 Pandemic: A Neurological Perspective date: 2020-04-29 journal: Cureus DOI: 10.7759/cureus.7889 sha: doc_id: 253704 cord_uid: y0t30xw3 file: cache/cord-253295-82ydczid.json key: cord-253295-82ydczid authors: Funkhouser, William K. title: Pathology: the clinical description of human disease date: 2020-07-24 journal: Essential Concepts in Molecular Pathology DOI: 10.1016/b978-0-12-813257-9.00011-5 sha: doc_id: 253295 cord_uid: 82ydczid file: cache/cord-253402-6sgeraws.json key: cord-253402-6sgeraws authors: Remuzzi, Andrea; Remuzzi, Giuseppe title: COVID-19 and Italy: what next? date: 2020-03-13 journal: Lancet DOI: 10.1016/s0140-6736(20)30627-9 sha: doc_id: 253402 cord_uid: 6sgeraws file: cache/cord-254446-yxqbe1dj.json key: cord-254446-yxqbe1dj authors: Ren, Yunzhao R.; Golding, Amit; Sorbello, Alfred; Ji, Ping; Chen, Jianmeng; Bhawana, Saluja; Witzmann, Kimberly; Arya, Vikram; Reynolds, Kellie S.; Choi, Su‐Young; Nikolov, Nikolay; Sahajwalla, Chandrahas title: A Comprehensive Updated Review on SARS‐CoV‐2 and COVID‐19 date: 2020-05-29 journal: J Clin Pharmacol DOI: 10.1002/jcph.1673 sha: doc_id: 254446 cord_uid: yxqbe1dj file: cache/cord-253746-15w4gquq.json key: cord-253746-15w4gquq authors: Goldman, Michel; Silva, Mitchell title: Reflections on the Collaborative Fight Against COVID-19 date: 2020-09-17 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00565 sha: doc_id: 253746 cord_uid: 15w4gquq file: cache/cord-253970-sbj869yy.json key: cord-253970-sbj869yy authors: Agarwal, Amit; Pinho, Marco; Raj, Karuna; Yu, Frank F.; Bathla, Girish; Achilleos, Michael; ONeill, Thomas; Still, Michael; Maldjian, Joseph title: Neurological emergencies associated with COVID-19: stroke and beyond date: 2020-08-11 journal: Emerg Radiol DOI: 10.1007/s10140-020-01837-7 sha: doc_id: 253970 cord_uid: sbj869yy file: cache/cord-254040-s3k51rkk.json key: cord-254040-s3k51rkk authors: Bombaci, Alessandro; Abbadessa, Gianmarco; Trojsi, Francesca; Leocani, Letizia; Bonavita, Simona; Lavorgna, Luigi title: Telemedicine for management of patients with amyotrophic lateral sclerosis through COVID-19 tail date: 2020-10-06 journal: Neurol Sci DOI: 10.1007/s10072-020-04783-x sha: doc_id: 254040 cord_uid: s3k51rkk file: cache/cord-254428-n0uwy77g.json key: cord-254428-n0uwy77g authors: Zhao, Wen; Yu, Shikai; Zha, Xiangyi; Wang, Ning; Pang, Qiumei; Li, Tongzeng; Li, Aixin title: Clinical characteristics and durations of hospitalized patients with COVID-19 in Beijing: a retrospective cohort study date: 2020-03-17 journal: nan DOI: 10.1101/2020.03.13.20035436 sha: doc_id: 254428 cord_uid: n0uwy77g file: cache/cord-254478-scc9wee0.json key: cord-254478-scc9wee0 authors: To, Kelvin Kai-Wang; Tsang, Owen Tak-Yin; Leung, Wai-Shing; Tam, Anthony Raymond; Wu, Tak-Chiu; Lung, David Christopher; Yip, Cyril Chik-Yan; Cai, Jian-Piao; Chan, Jacky Man-Chun; Chik, Thomas Shiu-Hong; Lau, Daphne Pui-Ling; Choi, Chris Yau-Chung; Chen, Lin-Lei; Chan, Wan-Mui; Chan, Kwok-Hung; Ip, Jonathan Daniel; Ng, Anthony Chin-Ki; Poon, Rosana Wing-Shan; Luo, Cui-Ting; Cheng, Vincent Chi-Chung; Chan, Jasper Fuk-Woo; Hung, Ivan Fan-Ngai; Chen, Zhiwei; Chen, Honglin; Yuen, Kwok-Yung title: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study date: 2020-03-23 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(20)30196-1 sha: doc_id: 254478 cord_uid: scc9wee0 file: cache/cord-253730-cdkzvfib.json key: cord-253730-cdkzvfib authors: Suzuki, Emily; Sakai, Tomoko; Hoshino, Chisato; Hirao, Masanobu; Yamaguchi, Reiko; Nakahara, Rui title: Assessment of the Need for Early Initiation of Rehabilitation Treatments in Patients with Coronavirus Disease 2019 date: 2020-08-13 journal: Prog Rehabil Med DOI: 10.2490/prm.20200018 sha: doc_id: 253730 cord_uid: cdkzvfib file: cache/cord-254990-nrzwn6oz.json key: cord-254990-nrzwn6oz authors: Mayer, Kirby P.; Sturgill, Jamie L.; Kalema, Anna G.; Soper, Melissa K.; Seif, Sherif M.; Cassity, Evan P.; Hatton Kolpek, Jimmi; Dupont-Versteegden, Esther E.; Montgomery-Yates, Ashley A.; Morris, Peter E. title: Recovery from COVID-19 and acute respiratory distress syndrome: the potential role of an intensive care unit recovery clinic: a case report date: 2020-09-10 journal: J Med Case Rep DOI: 10.1186/s13256-020-02481-y sha: doc_id: 254990 cord_uid: nrzwn6oz file: cache/cord-255233-rvgj6pvk.json key: cord-255233-rvgj6pvk authors: Munday, Molly-Rose; Rodricks, Rohan; Fitzpatrick, Michael; Flood, Victoria M.; Gunton, Jenny E. title: A Pilot Study Examining Vitamin C Levels in Periodontal Patients date: 2020-07-28 journal: Nutrients DOI: 10.3390/nu12082255 sha: doc_id: 255233 cord_uid: rvgj6pvk file: cache/cord-255197-79yfslu1.json key: cord-255197-79yfslu1 authors: Soo, Chun Ian; Chan, Yeow; Loh, Ee Chin; Pang, Yong Kek title: Telehealth: “virtual” lifeline for home-ventilated patients during the COVID-19 pandemic date: 2020-09-28 journal: ERJ Open Res DOI: 10.1183/23120541.00399-2020 sha: doc_id: 255197 cord_uid: 79yfslu1 file: cache/cord-005453-4057qib7.json key: cord-005453-4057qib7 authors: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 journal: Bone Marrow Transplant DOI: 10.1038/s41409-019-0559-4 sha: doc_id: 5453 cord_uid: 4057qib7 file: cache/cord-254025-j1l0mder.json key: cord-254025-j1l0mder authors: de Melo, Andreia C.; Thuler, Luiz C. S.; da Silva, Jesse L.; de Albuquerque, Lucas Z.; Pecego, Ana C.; Rodrigues, Luciana de O. R.; da Conceição, Magda S.; Garrido, Marianne M.; Quintella Mendes, Gelcio L.; Mendes Pereira, Ana Cristina P.; Soares, Marcelo A.; Viola, João P. B. title: Cancer inpatients with COVID-19: A report from the Brazilian National Cancer Institute date: 2020-10-26 journal: PLoS One DOI: 10.1371/journal.pone.0241261 sha: doc_id: 254025 cord_uid: j1l0mder file: cache/cord-254993-bndl93qr.json key: cord-254993-bndl93qr authors: Sonnweber, Thomas; Boehm, Anna; Sahanic, Sabina; Pizzini, Alex; Aichner, Magdalena; Sonnweber, Bettina; Kurz, Katharina; Koppelstätter, Sabine; Haschka, David; Petzer, Verena; Hilbe, Richard; Theurl, Markus; Lehner, Daniela; Nairz, Manfred; Puchner, Bernhard; Luger, Anna; Schwabl, Christoph; Bellmann-Weiler, Rosa; Wöll, Ewald; Widmann, Gerlig; Tancevski, Ivan; Judith-Löffler-Ragg; Weiss, Günter title: Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study date: 2020-10-21 journal: Respir Res DOI: 10.1186/s12931-020-01546-2 sha: doc_id: 254993 cord_uid: bndl93qr file: cache/cord-254357-5s84kimn.json key: cord-254357-5s84kimn authors: Morse, Alan R; Seiple, William H title: Decreasing Avoidable Vision Loss: Identifying Antecedents of Adherence date: 2020-11-02 journal: Clin Ophthalmol DOI: 10.2147/opth.s278627 sha: doc_id: 254357 cord_uid: 5s84kimn file: cache/cord-254852-qr5gdmbc.json key: cord-254852-qr5gdmbc authors: Grief, Samuel N.; Loza, Julie K. title: Guidelines for the Evaluation and Treatment of Pneumonia date: 2018-08-14 journal: Prim Care DOI: 10.1016/j.pop.2018.04.001 sha: doc_id: 254852 cord_uid: qr5gdmbc file: cache/cord-255256-8uckmya4.json key: cord-255256-8uckmya4 authors: nan title: Akzeptierte Abstracts für die COVID-19-bedingt abgesagte DGIIN/ÖGIAIN-Jahrestagung 2020 date: 2020-08-18 journal: Med Klin Intensivmed Notfmed DOI: 10.1007/s00063-020-00711-1 sha: doc_id: 255256 cord_uid: 8uckmya4 file: cache/cord-254419-qw83atrx.json key: cord-254419-qw83atrx authors: Bhattacharyya, Rajat; Iyer, Prasad; Phua, Ghee Chee; Lee, Jan Hau title: The Interplay Between Coagulation and Inflammation Pathways in COVID-19-Associated Respiratory Failure: A Narrative Review date: 2020-08-25 journal: Pulm Ther DOI: 10.1007/s41030-020-00126-5 sha: doc_id: 254419 cord_uid: qw83atrx file: cache/cord-255300-btyth32l.json key: cord-255300-btyth32l authors: Kang, Swan; Thomas, Peter B. M.; Sim, Dawn A.; Parker, Richard T.; Daniel, Claire; Uddin, Jimmy M. title: Oculoplastic video-based telemedicine consultations: Covid-19 and beyond date: 2020-05-12 journal: Eye (Lond) DOI: 10.1038/s41433-020-0953-6 sha: doc_id: 255300 cord_uid: btyth32l file: cache/cord-255267-o8k5ep9y.json key: cord-255267-o8k5ep9y authors: Gan, Connie Cai Ru; Tseng, Yu-Chi; Lee, Feng-You; Lee, Kuan-I title: Personal ventilation hood for protecting healthcare workers from aerosol-transmissible diseases date: 2020-07-22 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.07.036 sha: doc_id: 255267 cord_uid: o8k5ep9y file: cache/cord-255490-gyq6cpc9.json key: cord-255490-gyq6cpc9 authors: Wang, Chang‐Zheng; Hu, Shun‐Lin; Wang, Lin; Li, Min; Li, Huan‐Tian title: Early risk factors of the exacerbation of Coronavirus disease 2019 pneumonia date: 2020-05-29 journal: J Med Virol DOI: 10.1002/jmv.26071 sha: doc_id: 255490 cord_uid: gyq6cpc9 file: cache/cord-255240-ltatgq3e.json key: cord-255240-ltatgq3e authors: Kesserwani, Hassan title: Cerebral Microbleeds - To Treat or Not to Treat, That Is the Question: A Case Report With a Note on Its Radiologic Deconstruction and Therapeutic Nuances date: 2020-09-20 journal: Cureus DOI: 10.7759/cureus.10548 sha: doc_id: 255240 cord_uid: ltatgq3e file: cache/cord-254377-j8e8gb0l.json key: cord-254377-j8e8gb0l authors: Ali, Sadaf; Pappachan, Joseph M.; Mathew, Smitha title: Acute cor pulmonale from saddle pulmonary embolism in a patient with previous Covid-19 – should we prolong prophylactic anticoagulation? date: 2020-06-13 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.06.039 sha: doc_id: 254377 cord_uid: j8e8gb0l file: cache/cord-254382-xy8se56o.json key: cord-254382-xy8se56o authors: Santos, C.; Rhee, Y.; Hollinger, E.; Olaitan, O.; Schadde, E.; Peev, V.; Saltzberg, S.; Hertl, M. title: Comparative Incidence and Outcomes of COVID-19 in Kidney or Kidney-Pancreas Transplant Recipients Versus Kidney or Kidney-Pancreas Waitlisted Patients: A Pilot Study date: 2020-07-25 journal: nan DOI: 10.1101/2020.07.20.20157990 sha: doc_id: 254382 cord_uid: xy8se56o file: cache/cord-254777-h8hw4m9f.json key: cord-254777-h8hw4m9f authors: Tanner, Tamara; Wahezi, Dawn M. title: Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19 date: 2020-07-29 journal: Paediatr Respir Rev DOI: 10.1016/j.prrv.2020.07.003 sha: doc_id: 254777 cord_uid: h8hw4m9f file: cache/cord-255393-aknebauo.json key: cord-255393-aknebauo authors: Piccoli, Giorgina Barbara; Torreggiani, Massimo; Gendrot, Lurlynis; Nielsen, Louise title: Setting the clock back: new hope for dialysis patients. Sodium thiosulphate and the regression of vascular calcifications date: 2020-05-16 journal: J Nephrol DOI: 10.1007/s40620-020-00744-x sha: doc_id: 255393 cord_uid: aknebauo file: cache/cord-255746-ir73lpi8.json key: cord-255746-ir73lpi8 authors: Sirimaturos, Michael; Gotur, Deepa B.; Patel, Samir J.; Dreucean, Diane; Jakowenko, Nicholas; Cooper, Megan H.; Brahmbhatt, Nishal; Graviss, Edward A.; Nguyen, Duc T.; Pingali, Sai Ravi; Lin, Jiejian; Musick, William L. title: Clinical Outcomes Following Tocilizumab Administration in Mechanically Ventilated Coronavirus Disease 2019 Patients date: 2020-10-01 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000232 sha: doc_id: 255746 cord_uid: ir73lpi8 file: cache/cord-254595-by2j7byz.json key: cord-254595-by2j7byz authors: Rao, Sandesh S.; Loeb, Alexander E.; Amin, Raj M.; Golladay, Gregory J.; Levin, Adam S.; Thakkar, Savyasachi C. title: Establishing Telemedicine in an Academic Total Joint Arthroplasty Practice: Needs and Opportunities Highlighted by the COVID-19 Pandemic date: 2020-04-23 journal: Arthroplast Today DOI: 10.1016/j.artd.2020.04.014 sha: doc_id: 254595 cord_uid: by2j7byz file: cache/cord-023211-kt5gt26t.json key: cord-023211-kt5gt26t authors: nan title: Poster Session Abstracts date: 2007-08-29 journal: Pediatr Pulmonol DOI: 10.1002/ppul.20700 sha: doc_id: 23211 cord_uid: kt5gt26t file: cache/cord-255519-tcobane8.json key: cord-255519-tcobane8 authors: Bartels, Matthew N.; Prince, David Z. title: Acute Medical Conditions: Cardiopulmonary Disease, Medical Frailty, and Renal Failure date: 2020-10-02 journal: Braddom's Physical Medicine and Rehabilitation DOI: 10.1016/b978-0-323-62539-5.00027-8 sha: doc_id: 255519 cord_uid: tcobane8 file: cache/cord-255831-nrc35tug.json key: cord-255831-nrc35tug authors: Alviggi, Carlo; Esteves, Sandro C.; Orvieto, Raoul; Conforti, Alessandro; La Marca, Antonio; Fischer, Robert; Andersen, Claus Y.; Bühler, Klaus; Sunkara, Sesh K.; Polyzos, Nikolaos P.; Strina, Ida; Carbone, Luigi; Bento, Fabiola C.; Galliano, Daniela; Yarali, Hakan; Vuong, Lan N.; Grynberg, Michael; Drakopoulos, Panagiotis; Xavier, Pedro; Llacer, Joaquin; Neuspiller, Fernando; Horton, Marcos; Roque, Matheus; Papanikolaou, Evangelos; Banker, Manish; Dahan, Michael H.; Foong, Shu; Tournaye, Herman; Blockeel, Christophe; Vaiarelli, Alberto; Humaidan, Peter; Ubaldi, Filippo M. title: COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management date: 2020-05-13 journal: Reprod Biol Endocrinol DOI: 10.1186/s12958-020-00605-z sha: doc_id: 255831 cord_uid: nrc35tug file: cache/cord-256109-dkp0fwe3.json key: cord-256109-dkp0fwe3 authors: Mazzulli, Tony; Farcas, Gabriella A.; Poutanen, Susan M.; Willey, Barbara M.; Low, Donald E.; Butany, Jagdish; Asa, Sylvia L.; Kain, Kevin C. title: Severe Acute Respiratory Syndrome–associated Coronavirus in Lung Tissue date: 2004-01-17 journal: Emerg Infect Dis DOI: 10.3201/eid1001.030404 sha: doc_id: 256109 cord_uid: dkp0fwe3 file: cache/cord-256011-0cr4ejxu.json key: cord-256011-0cr4ejxu authors: de Castro-Hamoy, Leniza; de Castro, Leonardo D. title: Age Matters but it should not be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID-19 date: 2020-06-16 journal: Asian Bioeth Rev DOI: 10.1007/s41649-020-00130-6 sha: doc_id: 256011 cord_uid: 0cr4ejxu file: cache/cord-256262-lwc4ghj2.json key: cord-256262-lwc4ghj2 authors: Gangneux, Jean-Pierre; Bougnoux, Marie-Elisabeth; Dannaoui, Eric; Cornet, Muriel; Jean Ralph, ZAHAR title: Invasive fungal diseases during COVID-19: We should be prepared date: 2020-04-06 journal: J Mycol Med DOI: 10.1016/j.mycmed.2020.100971 sha: doc_id: 256262 cord_uid: lwc4ghj2 file: cache/cord-256051-87alqfkd.json key: cord-256051-87alqfkd authors: Revzin, Margarita V.; Raza, Sarah; Warshawsky, Robin; D’Agostino, Catherine; Srivastava, Neil C.; Bader, Anna S.; Malhotra, Ajay; Patel, Ritesh D.; Chen, Kan; Kyriakakos, Christopher; Pellerito, John S. title: Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications date: 2020-10-01 journal: Radiographics DOI: 10.1148/rg.2020200149 sha: doc_id: 256051 cord_uid: 87alqfkd file: cache/cord-254494-wbfgrez1.json key: cord-254494-wbfgrez1 authors: Shi, Chunhong; Zhu, Haili; Liu, Jun; Zhou, Jian; Tang, Weihong title: Barriers to Self-Management of Type 2 Diabetes During COVID-19 Medical Isolation: A Qualitative Study date: 2020-10-14 journal: Diabetes Metab Syndr Obes DOI: 10.2147/dmso.s268481 sha: doc_id: 254494 cord_uid: wbfgrez1 file: cache/cord-255037-i9guxtix.json key: cord-255037-i9guxtix authors: Reda, Gianluigi; Noto, Alessandro; Cassin, Ramona; Zamprogna, Giulia; Borella, Chiara; Scarfò, Lydia; Farina, Lucia; Molteni, Alfredo; Ghia, Paolo; Tedeschi, Alessandra; Montillo, Marco title: Reply to “CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report” Analysis of six hematological centers in Lombardy: On behalf of CLL commission of Lombardy Hematology Network (REL) date: 2020-08-04 journal: Leukemia DOI: 10.1038/s41375-020-0966-y sha: doc_id: 255037 cord_uid: i9guxtix file: cache/cord-255435-mr239gai.json key: cord-255435-mr239gai authors: Sher, Yelizaveta; Rabkin, Beatrice; Maldonado, Jose R.; Mohabir, Paul title: A CASE REPORT OF COVID-19 ASSOCIATED HYPERACTIVE ICU DELIRIUM WITH PROPOSED PATHOPHYSIOLOGY AND TREATMENT date: 2020-05-19 journal: Psychosomatics DOI: 10.1016/j.psym.2020.05.007 sha: doc_id: 255435 cord_uid: mr239gai file: cache/cord-256459-6h358si5.json key: cord-256459-6h358si5 authors: Sharpstone, D; Gazzard, B title: Gastrointestinal manifestations of HIV infection date: 1996-08-10 journal: Lancet DOI: 10.1016/s0140-6736(96)01034-3 sha: doc_id: 256459 cord_uid: 6h358si5 file: cache/cord-255460-r5p5helx.json key: cord-255460-r5p5helx authors: Aggarwal, Sadhna; Verma, Sumit Singh; Aggarwal, Sumit; Gupta, Subash Chandra title: Drug repurposing for breast cancer therapy: Old weapon for new battle date: 2019-09-21 journal: Semin Cancer Biol DOI: 10.1016/j.semcancer.2019.09.012 sha: doc_id: 255460 cord_uid: r5p5helx file: cache/cord-255807-7goz1agp.json key: cord-255807-7goz1agp authors: Hak, E.; Hoes, A. W.; Grobbee, D. E.; Lammers, J. W. J.; van Essen, G. A.; van Loon, A. M.; Verheij, T. J. M. title: Conventional Influenza Vaccination Is Not Associated with Complications in Working-Age Patients with Asthma or Chronic Obstructive Pulmonary Disease date: 2003-04-15 journal: Am J Epidemiol DOI: 10.1093/aje/kwg027 sha: doc_id: 255807 cord_uid: 7goz1agp file: cache/cord-256030-5xzuilc1.json key: cord-256030-5xzuilc1 authors: Michel, Pierre-Antoine; Piccoli, Giorgina Barbara; Couchoud, Cécile; Fessi, Hafedh title: Home hemodialysis during the COVID-19 epidemic: comment on the French experience from the viewpoint of a French home hemodialysis care network date: 2020-11-11 journal: J Nephrol DOI: 10.1007/s40620-020-00893-z sha: doc_id: 256030 cord_uid: 5xzuilc1 file: cache/cord-256117-t9v1hng5.json key: cord-256117-t9v1hng5 authors: Al Kasab, Sami; Almallouhi, Eyad; Spiotta, Alejandro M. title: Acute Stroke Management During the Coronavirus Disease 2019 (COVID-19) Pandemic: From Trough of Disillusionment to Slope of Enlightenment date: 2020-06-03 journal: World Neurosurg DOI: 10.1016/j.wneu.2020.04.153 sha: doc_id: 256117 cord_uid: t9v1hng5 file: cache/cord-010119-t1x9gknd.json key: cord-010119-t1x9gknd authors: nan title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 journal: Transfusion DOI: 10.1111/trf.14286 sha: doc_id: 10119 cord_uid: t1x9gknd file: cache/cord-256290-pyrmtps3.json key: cord-256290-pyrmtps3 authors: Kerr, Colm; Hughes, Gerry; Mckenna, Louise; Bergin, Colm title: Prevalence of smell and taste dysfunction in a cohort of CoVID19 outpatients managed through remote consultation from a large urban teaching hospital in Dublin, Ireland date: 2020-07-15 journal: nan DOI: 10.1016/j.infpip.2020.100076 sha: doc_id: 256290 cord_uid: pyrmtps3 file: cache/cord-256888-tdx12ccj.json key: cord-256888-tdx12ccj authors: Bradley, Benjamin T; Maioli, Heather; Johnston, Robert; Chaudhry, Irfan; Fink, Susan L; Xu, Haodong; Najafian, Behzad; Deutsch, Gail; Lacy, J Matthew; Williams, Timothy; Yarid, Nicole; Marshall, Desiree A title: Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series date: 2020-07-16 journal: Lancet DOI: 10.1016/s0140-6736(20)31305-2 sha: doc_id: 256888 cord_uid: tdx12ccj file: cache/cord-256618-tt3p0tki.json key: cord-256618-tt3p0tki authors: Liao, Yun; Ma, Chunlai; Lau, Alan H; Zhong, Mingkang title: Role of pharmacists during the COVID‐19 pandemic in China ‐ Shanghai Experiences date: 2020-06-14 journal: J Am Coll Clin Pharm DOI: 10.1002/jac5.1288 sha: doc_id: 256618 cord_uid: tt3p0tki file: cache/cord-257035-ob1xncbs.json key: cord-257035-ob1xncbs authors: Rigatelli, Gianluca; Zuin, Marco; Rigatelli, Alberto; Zuliani, Giovanni; Roncon, Loris title: Intubation and Ventilation amid COVID-19: Comment date: 2020-05-11 journal: Anesthesiology DOI: 10.1097/aln.0000000000003374 sha: doc_id: 257035 cord_uid: ob1xncbs file: cache/cord-256535-fz5p2u6p.json key: cord-256535-fz5p2u6p authors: Oki, Sogo; Kawabori, Masahito; Echizenya, Sumire; Shimoda, Yusuke; Shimbo, Daisuke; Osanai, Toshiya; Uchida, Kazuki; Houkin, Kiyohiro title: Long-Term Clinical Outcome and Prognosis After Thrombectomy in Patients With Concomitant Malignancy date: 2020-10-15 journal: Front Neurol DOI: 10.3389/fneur.2020.572589 sha: doc_id: 256535 cord_uid: fz5p2u6p file: cache/cord-256508-ce59ovan.json key: cord-256508-ce59ovan authors: Asselah, Tarik; Durantel, David; Pasmant, Eric; Lau, George; Schinazi, Raymond F. title: COVID-19: discovery, diagnostics and drug development date: 2020-10-08 journal: J Hepatol DOI: 10.1016/j.jhep.2020.09.031 sha: doc_id: 256508 cord_uid: ce59ovan file: cache/cord-255805-wlr8nod3.json key: cord-255805-wlr8nod3 authors: Liu, Yan; Wang, Meifang; Luo, Guoshi; Qian, Xin; Wu, Chenglin; Zhang, Yizhong; Chen, Biyu; Leung, Elaine Lai-Han; Tang, Yijun title: Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19: A case report date: 2020-10-16 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000022577 sha: doc_id: 255805 cord_uid: wlr8nod3 file: cache/cord-255652-3n2dxljj.json key: cord-255652-3n2dxljj authors: Challener, Douglas W.; Challener, Gregory J.; Gow-Lee, Vanessa J.; Fida, Madiha; Shah, Aditya S.; O’Horo, John C. title: Screening for COVID-19: Patient factors predicting positive PCR test date: 2020-05-19 journal: Infection control and hospital epidemiology DOI: 10.1017/ice.2020.249 sha: doc_id: 255652 cord_uid: 3n2dxljj file: cache/cord-255905-ti9b1etu.json key: cord-255905-ti9b1etu authors: Qiu, Chengfeng; Xiao, Qian; Liao, Xin; Deng, Ziwei; Liu, Huiwen; Shu, Yuanlu; Zhou, Dinghui; Deng, Ye; Wang, Hongqiang; Zhao, Xiang; Zhou, Jianliang; Wang, Jin; Shi, Zhihua; Da, Long title: Transmission and clinical characteristics of coronavirus disease 2019 in 104 outside-Wuhan patients, China date: 2020-03-06 journal: nan DOI: 10.1101/2020.03.04.20026005 sha: doc_id: 255905 cord_uid: ti9b1etu file: cache/cord-257274-fzyamd7v.json key: cord-257274-fzyamd7v authors: Peiro-Garcia, Alejandro; Corominas, Laura; Coelho, Alexandre; DeSena-DeCabo, Lidia; Torner-Rubies, Ferran; Fontecha, Cesar G. title: How the COVID-19 pandemic is affecting paediatric orthopaedics practice: a preliminary report date: 2020-06-01 journal: J Child Orthop DOI: 10.1302/1863-2548.14.200099 sha: doc_id: 257274 cord_uid: fzyamd7v file: cache/cord-256556-1zea3wa1.json key: cord-256556-1zea3wa1 authors: Lou, Yan; Liu, Lin; Yao, Hangping; Hu, Xingjiang; Su, Junwei; Xu, Kaijin; Luo, Rui; Yang, Xi; He, Lingjuan; Lu, Xiaoyang; Zhao, Qingwei; Liang, Tingbo; Qiu, Yunqing title: Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial date: 2020-10-25 journal: Eur J Pharm Sci DOI: 10.1016/j.ejps.2020.105631 sha: doc_id: 256556 cord_uid: 1zea3wa1 file: cache/cord-256849-8w2avwo2.json key: cord-256849-8w2avwo2 authors: Koenig, Kristi L.; Alassaf, Wajdan; Burns, Michael J. title: Identify-Isolate-Inform: A Tool for Initial Detection and Management of Measles Patients in the Emergency Department date: 2015-03-18 journal: West J Emerg Med DOI: 10.5811/westjem.2015.3.25678 sha: doc_id: 256849 cord_uid: 8w2avwo2 file: cache/cord-257206-av2k44ig.json key: cord-257206-av2k44ig authors: Chen, Ruey; Chou, Kuei-Ru; Huang, Yu-Jou; Wang, Tzong-Shi; Liu, Shu-Yen; Ho, Li-Yuan title: Effects of a SARS prevention programme in Taiwan on nursing staff's anxiety, depression and sleep quality: A longitudinal survey date: 2006-02-28 journal: International Journal of Nursing Studies DOI: 10.1016/j.ijnurstu.2005.03.006 sha: doc_id: 257206 cord_uid: av2k44ig file: cache/cord-256639-4e0irb6d.json key: cord-256639-4e0irb6d authors: Jean-Michel, Vanessa; Caulier, Thomas; Delannoy, Pierre-Yves; Meybeck, Agnes; Georges, Hugues title: Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation date: 2020-09-06 journal: Med Intensiva DOI: 10.1016/j.medin.2020.07.013 sha: doc_id: 256639 cord_uid: 4e0irb6d file: cache/cord-256893-3sh87h2x.json key: cord-256893-3sh87h2x authors: Yang, Li; Liu, Shasha; Liu, Jinyan; Zhang, Zhixin; Wan, Xiaochun; Huang, Bo; Chen, Youhai; Zhang, Yi title: COVID-19: immunopathogenesis and Immunotherapeutics date: 2020-07-25 journal: Signal Transduct Target Ther DOI: 10.1038/s41392-020-00243-2 sha: doc_id: 256893 cord_uid: 3sh87h2x file: cache/cord-257147-i48qljv6.json key: cord-257147-i48qljv6 authors: Karakas, Mahir; Jarczak, Dominik; Becker, Martin; Roedl, Kevin; Addo, Marylyn M.; Hein, Frauke; Bergmann, Andreas; Zimmermann, Jens; Simon, Tim-Philipp; Marx, Gernot; Lütgehetmann, Marc; Nierhaus, Axel; Kluge, Stefan title: Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) date: 2020-08-11 journal: Biomolecules DOI: 10.3390/biom10081171 sha: doc_id: 257147 cord_uid: i48qljv6 file: cache/cord-257504-tqzvdssb.json key: cord-257504-tqzvdssb authors: Dubost, Clément; Pasquier, Pierre; Kearns, Kévin; Ficko, Cécile; Rapp, Christophe; Wolff, Michel; Richard, Jean-Christophe; Diehl, Jean-Luc; Le Tulzo, Yves; Mérat, Stéphane title: Preparation of an intensive care unit in France for the reception of a confirmed case of Ebola virus infection() date: 2015-11-24 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2015.10.002 sha: doc_id: 257504 cord_uid: tqzvdssb file: cache/cord-257276-h5542vqg.json key: cord-257276-h5542vqg authors: Euchi, Jalel; Zidi, Salah; Laouamer, Lamri title: A Hybrid Approach to Solve the Vehicle Routing Problem with Time Windows and Synchronized Visits In-Home Health Care date: 2020-08-05 journal: Arab J Sci Eng DOI: 10.1007/s13369-020-04828-5 sha: doc_id: 257276 cord_uid: h5542vqg file: cache/cord-256856-jw1d6uig.json key: cord-256856-jw1d6uig authors: Sohinki, Daniel; Berman, Adam E. title: What Coronavirus Disease 2019 Has Taught Us About Modern Electrophysiology Practice date: 2020-08-15 journal: J Innov Card Rhythm Manag DOI: 10.19102/icrm.2020.110801 sha: doc_id: 256856 cord_uid: jw1d6uig file: cache/cord-257600-0plhquk9.json key: cord-257600-0plhquk9 authors: Calles, Antonio; Aparicio, María Inmaculada; Alva, Manuel; Bringas, Marianela; Gutierrez, Natalia; Soto, Javier; Arregui, Marta; Tirado, Victoria Clara; Álvarez, Enrique Luis; del Monte-Millán, María; Massarrah, Tatiana; Galera, Mar; Álvarez, Rosa; Martín, Miguel title: Outcomes of COVID-19 in Patients With Lung Cancer Treated in a Tertiary Hospital in Madrid date: 2020-09-16 journal: Front Oncol DOI: 10.3389/fonc.2020.01777 sha: doc_id: 257600 cord_uid: 0plhquk9 file: cache/cord-257717-fbfe5vt4.json key: cord-257717-fbfe5vt4 authors: Wallis, Christopher J.D.; Catto, James W.F.; Finelli, Antonio; Glaser, Adam W.; Gore, John L.; Loeb, Stacy; Morgan, Todd M.; Morgans, Alicia K.; Mottet, Nicolas; Neal, Richard; O’Brien, Tim; Odisho, Anobel Y.; Powles, Thomas; Skolarus, Ted A.; Smith, Angela B.; Szabados, Bernadett; Klaassen, Zachary; Spratt, Daniel E. title: The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future date: 2020-09-04 journal: Eur Urol DOI: 10.1016/j.eururo.2020.08.030 sha: doc_id: 257717 cord_uid: fbfe5vt4 file: cache/cord-257884-5exwwxin.json key: cord-257884-5exwwxin authors: Kumar, Rajesh; Kumar, Jathinder; Daly, Caroline; Edroos, Sadat Ali title: Acute pericarditis as a primary presentation of COVID-19 date: 2020-08-18 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-237617 sha: doc_id: 257884 cord_uid: 5exwwxin file: cache/cord-256864-v3mxcwru.json key: cord-256864-v3mxcwru authors: Tang, Yueting; Li, Yirong; Sun, Jiayu; Pan, Huaqin; Yao, Fen; Jiao, Xiaoyang title: Selection of an Optimal Combination Panel to Better Triage COVID-19 Hospitalized Patients date: 2020-10-27 journal: J Inflamm Res DOI: 10.2147/jir.s273193 sha: doc_id: 256864 cord_uid: v3mxcwru file: cache/cord-257344-d13at1y5.json key: cord-257344-d13at1y5 authors: Ghasemiyeh, Parisa; Mohammadi-Samani, Soliman title: COVID-19 Outbreak: Challenges in Pharmacotherapy Based on Pharmacokinetic and Pharmacodynamic Aspects of Drug Therapy in Patients with Moderate to Severe Infection date: 2020-09-18 journal: Heart Lung DOI: 10.1016/j.hrtlng.2020.08.025 sha: doc_id: 257344 cord_uid: d13at1y5 file: cache/cord-258027-f3rr5el1.json key: cord-258027-f3rr5el1 authors: Østby, Anne‐Cathrine; Gubbels, Sophie; Baake, Gerben; Nielsen, Lars Peter; Riedel, Casper; Arpi, Magnus title: Respiratory virology and microbiology in intensive care units: a prospective cohort study date: 2013-05-18 journal: APMIS DOI: 10.1111/apm.12089 sha: doc_id: 258027 cord_uid: f3rr5el1 file: cache/cord-256688-yy7abob9.json key: cord-256688-yy7abob9 authors: Chavez, Summer; Long, Brit; Koyfman, Alex; Liang, Stephen Y. title: Coronavirus Disease (COVID-19): A primer for emergency physicians date: 2020-03-24 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.03.036 sha: doc_id: 256688 cord_uid: yy7abob9 file: cache/cord-257051-ntnfu5ns.json key: cord-257051-ntnfu5ns authors: Tack, Christopher Topol; Grodon, Jack; Shorthouse, Faye; Spahr, Nicolas title: “Physio Anywhere”: digitally-enhanced outpatient care as a legacy of coronavirus 2020 date: 2020-07-18 journal: Physiotherapy DOI: 10.1016/j.physio.2020.07.004 sha: doc_id: 257051 cord_uid: ntnfu5ns file: cache/cord-258113-mnou31j3.json key: cord-258113-mnou31j3 authors: Wang, Yaping; Liao, Baolin; Guo, Yan; Li, Feng; Lei, Chunliang; Zhang, Fuchun; Cai, Weiping; Hong, Wenxin; Zeng, Yu; Qiu, Shuang; Wang, Jian; Li, Yueping; Deng, Xilong; Li, Jianping; Xiao, Guangming; Guo, Fengxia; Lai, Xunxi; Liang, Zhiwei; Wen, Xueliang; Li, Pinghong; Jiao, Qian; Xiang, Fangfei; Wang, Yong; Ma, Chenghui; Xie, Zhiwei; Lin, Weiyin; Wu, Yanrong; Tang, Xiaoping; Li, Linghua; Guan, Yujuan title: Clinical Characteristics of Patients Infected With the Novel 2019 Coronavirus (SARS-Cov-2) in Guangzhou, China date: 2020-05-19 journal: Open Forum Infect Dis DOI: 10.1093/ofid/ofaa187 sha: doc_id: 258113 cord_uid: mnou31j3 file: cache/cord-257408-ejhhk1iu.json key: cord-257408-ejhhk1iu authors: Goss, Matthew B.; Galván, N. Thao N.; Ruan, Wenly; Munoz, Flor M.; Brewer, Eileen D.; O’Mahony, Christine A.; Melicoff‐Portillo, Ernestina; Dreyer, William J.; Miloh, Tamir A.; Cigarroa, Francisco G.; Ranch, Daniel; Yoeli, Dor; Adams, Megan A.; Koohmaraie, Sarah; Harter, Diana M.; Rana, Abbas; Cotton, Ronald T.; Carter, Beth; Patel, Shreena; Moreno, Nicolas F.; Leung, Daniel H.; Goss, John A. title: The Pediatric Solid Organ Transplant Experience with COVID‐19: An Initial Multi‐Center, Multi‐Organ Case Series date: 2020-09-18 journal: Pediatr Transplant DOI: 10.1111/petr.13868 sha: doc_id: 257408 cord_uid: ejhhk1iu file: cache/cord-257467-b8o5ghvi.json key: cord-257467-b8o5ghvi authors: Smith, Barbara A. title: Anesthesia as a Risk for Health Care Acquired Infections date: 2010-12-31 journal: Perioperative Nursing Clinics DOI: 10.1016/j.cpen.2010.07.005 sha: doc_id: 257467 cord_uid: b8o5ghvi file: cache/cord-258067-par61wwh.json key: cord-258067-par61wwh authors: Di Martino, Marcello; García Septiem, Javier; Maqueda González, Rocío; Muñoz de Nova, Jose Luis; de la Hoz Rodríguez, Ángela; Correa Bonito, Alba; Martín-Pérez, Elena title: Elective Surgery During the SARS-CoV-2 Pandemic (COVID-19): A Morbimortality Analysis and Recommendations on Patient Prioritisation and Security Measures date: 2020-06-20 journal: nan DOI: 10.1016/j.cireng.2020.06.005 sha: doc_id: 258067 cord_uid: par61wwh file: cache/cord-258278-25rhf91v.json key: cord-258278-25rhf91v authors: Mowla, Ashkan; Sizdahkhani, Saman; Dorche, Maryam Sharifian; Selvan, Prad; Emanuel, Benjamin A.; Tenser, Matthew S.; Amar, Arun P.; Mack, William J. title: Unusual Pattern of Arterial Macrothrombosis Causing Stroke in a Young Adult Recovered from COVID-19 date: 2020-09-25 journal: J Stroke Cerebrovasc Dis DOI: 10.1016/j.jstrokecerebrovasdis.2020.105353 sha: doc_id: 258278 cord_uid: 25rhf91v file: cache/cord-258293-7q9zj8c2.json key: cord-258293-7q9zj8c2 authors: Marini, Alessandra; Iacoangeli, Maurizio; Dobran, Mauro title: Letter to the Editor Regarding 'Coronavirus Disease 2019 (COVID-19) and Neurosurgery: Literature and Neurosurgical Societies Recommendations Update' date: 2020-05-26 journal: World Neurosurg DOI: 10.1016/j.wneu.2020.05.160 sha: doc_id: 258293 cord_uid: 7q9zj8c2 file: cache/cord-256634-gg8hptfg.json key: cord-256634-gg8hptfg authors: Rhodes, N. J.; Dairem, A.; Moore, W.; Shah, A.; Postelnick, M. J.; Badowski, M. E.; Michienzi, S. M.; Borkowski, J. L.; Polisetty, R. S.; Fong, K.; Spivek, E. S.; Beardsley, J. R.; Hale, C. M.; Pallotta, A. M.; Srinivas, P.; Schulz, L. T. title: Multicenter point-prevalence evaluation of the utilization and safety of drug therapies for COVID-19 date: 2020-06-06 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.06.03.20121558 sha: doc_id: 256634 cord_uid: gg8hptfg file: cache/cord-257781-ybpliz32.json key: cord-257781-ybpliz32 authors: Jones, Eben; Gould, Allon; Pillay, Timesh D.; Khorasanee, Reza; Sykes, Richard; Bazo-Alvarez, Juan Carlos; Cox, Charlie; Shurovi, Badrun; Isted, Alexander; Simpson, Thomas; Jennings, Mick; Breeze, Richard; Khaliq, Waqas title: Subcutaneous Emphysema, Pneumomediastinum, and Pneumothorax in Critically Ill Patients With Coronavirus Disease 2019: A Retrospective Cohort Study date: 2020-09-17 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000210 sha: doc_id: 257781 cord_uid: ybpliz32 file: cache/cord-257839-kfzc4pwq.json key: cord-257839-kfzc4pwq authors: Ferguson, Katie; Quail, Nathaniel; Kewin, Peter; Blyth, Kevin G title: COVID-19 associated with extensive pulmonary arterial, intracardiac and peripheral arterial thrombosis date: 2020-08-03 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-237460 sha: doc_id: 257839 cord_uid: kfzc4pwq file: cache/cord-258416-1jrbu8ox.json key: cord-258416-1jrbu8ox authors: Drenovska, Kossara; Schmidt, Enno; Vassileva, Snejina title: Covid‐19 pandemic and the skin date: 2020-09-21 journal: Int J Dermatol DOI: 10.1111/ijd.15189 sha: doc_id: 258416 cord_uid: 1jrbu8ox file: cache/cord-258548-1u7v1nlr.json key: cord-258548-1u7v1nlr authors: Mansueto, Gelsomina; Niola, Massimo; Napoli, Claudio title: Can COVID 2019 disease induces a specific cardiovascular damage or it exacerbates pre-existing cardiovascular diseases? date: 2020-06-26 journal: Pathol Res Pract DOI: 10.1016/j.prp.2020.153086 sha: doc_id: 258548 cord_uid: 1u7v1nlr file: cache/cord-257732-3xuy6tbn.json key: cord-257732-3xuy6tbn authors: Azzi, Lorenzo; Carcano, Giulio; Gianfagna, Francesco; Grossi, Paolo; Gasperina, Daniela Dalla; Genoni, Angelo; Fasano, Mauro; Sessa, Fausto; Tettamanti, Lucia; Carinci, Francesco; Maurino, Vittorio; Rossi, Agostino; Tagliabue, Angelo; Baj, Andreina title: Saliva is a reliable tool to detect SARS-CoV-2 date: 2020-04-14 journal: J Infect DOI: 10.1016/j.jinf.2020.04.005 sha: doc_id: 257732 cord_uid: 3xuy6tbn file: cache/cord-257336-rpx71ww5.json key: cord-257336-rpx71ww5 authors: Doukas, Sotirios G.; Kavali, Leena; Menon, Rohan S.; Izotov, Boris N.; Bukhari, Amar title: E-cigarette or vaping induced lung injury: A case series and literature review date: 2020-10-03 journal: Toxicol Rep DOI: 10.1016/j.toxrep.2020.09.010 sha: doc_id: 257336 cord_uid: rpx71ww5 file: cache/cord-257433-qgkwylmk.json key: cord-257433-qgkwylmk authors: Candeloro, Elisa; Carimati, Federico; Tabaee Damavandi, Payam; Princiotta Cariddi, Lucia; Banfi, Paola; Clemenzi, Alessandro; Gallazzi, Marco; Mauri, Marco; Rebecchi, Valentina; Baruzzi, Fabio; Giorgianni, Andrea; Tozzi, Matteo; Bianchi, Massimo; Ageno, Walter; Versino, Maurizio title: An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era date: 2020-10-15 journal: Front Neurol DOI: 10.3389/fneur.2020.01029 sha: doc_id: 257433 cord_uid: qgkwylmk file: cache/cord-258093-6fn8ei9f.json key: cord-258093-6fn8ei9f authors: Hanania, Nicola A.; King, Monroe J.; Braman, Sidney S.; Saltoun, Carol; Wise, Robert A.; Enright, Paul; Falsey, Ann R.; Mathur, Sameer K.; Ramsdell, Joe W.; Rogers, Linda; Stempel, David A.; Lima, John J.; Fish, James E.; Wilson, Sandra R.; Boyd, Cynthia; Patel, Kushang V.; Irvin, Charles G.; Yawn, Barbara P.; Halm, Ethan A.; Wasserman, Stephen I.; Sands, Mark F.; Ershler, William B.; Ledford, Dennis K. title: Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop date: 2011-08-25 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2011.06.048 sha: doc_id: 258093 cord_uid: 6fn8ei9f file: cache/cord-257309-sazs5wgh.json key: cord-257309-sazs5wgh authors: Ho, Hsi-en; Mathew, Sheryl; Peluso, Michael J.; Cunningham-Rundles, Charlotte title: Clinical Outcomes and Features of Covid-19 in Patients with Primary Immunodeficiencies in New York City date: 2020-10-08 journal: J Allergy Clin Immunol Pract DOI: 10.1016/j.jaip.2020.09.052 sha: doc_id: 257309 cord_uid: sazs5wgh file: cache/cord-257729-s0vo7dlk.json key: cord-257729-s0vo7dlk authors: Bauer, Melissa; Bernstein, Kyra; Dinges, Emily; Delgado, Carlos; El-Sharawi, Nadir; Sultan, Pervez; Mhyre, Jill M.; Landau, Ruth title: Obstetric Anesthesia During the Coronavirus Disease 2019 Pandemic date: 2020-04-20 journal: Anesth Analg DOI: 10.1213/ane.0000000000004856 sha: doc_id: 257729 cord_uid: s0vo7dlk file: cache/cord-258117-5gpo8smn.json key: cord-258117-5gpo8smn authors: Le Naour, Julie; Galluzzi, Lorenzo; Zitvogel, Laurence; Kroemer, Guido; Vacchelli, Erika title: Trial watch: IDO inhibitors in cancer therapy date: 2020-06-14 journal: Oncoimmunology DOI: 10.1080/2162402x.2020.1777625 sha: doc_id: 258117 cord_uid: 5gpo8smn file: cache/cord-258727-mhg56j20.json key: cord-258727-mhg56j20 authors: Kolar, Dusan title: Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic date: 2020-08-08 journal: Eur Arch Psychiatry Clin Neurosci DOI: 10.1007/s00406-020-01182-3 sha: doc_id: 258727 cord_uid: mhg56j20 file: cache/cord-258708-da6x5rxa.json key: cord-258708-da6x5rxa authors: Hafiane, Anouar title: SARS-CoV-2 and the cardiovascular system date: 2020-07-16 journal: Clin Chim Acta DOI: 10.1016/j.cca.2020.07.019 sha: doc_id: 258708 cord_uid: da6x5rxa file: cache/cord-258583-5qdthy0j.json key: cord-258583-5qdthy0j authors: Yan, He; Lu, Shanshan; Chen, Liangpei; Wang, Yufang; Liu, Qiaomei; Li, Dongsheng; Yan, Xisheng; Yan, Jie title: Multiple organ injury on admission predicts in‐hospital mortality in patients with COVID‐19 date: 2020-09-30 journal: J Med Virol DOI: 10.1002/jmv.26534 sha: doc_id: 258583 cord_uid: 5qdthy0j file: cache/cord-258576-ywbyflas.json key: cord-258576-ywbyflas authors: Bösmüller, Hans; Traxler, Selina; Bitzer, Michael; Häberle, Helene; Raiser, Wolfgang; Nann, Dominik; Frauenfeld, Leonie; Vogelsberg, Antonio; Klingel, Karin; Fend, Falko title: The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation date: 2020-06-30 journal: Virchows Arch DOI: 10.1007/s00428-020-02881-x sha: doc_id: 258576 cord_uid: ywbyflas file: cache/cord-258692-dch1utis.json key: cord-258692-dch1utis authors: Mead, Kenneth; Johnson, David L. title: An evaluation of portable high-efficiency particulate air filtration for expedient patient isolation in epidemic and emergency response date: 2004-10-22 journal: Ann Emerg Med DOI: 10.1016/j.annemergmed.2004.07.451 sha: doc_id: 258692 cord_uid: dch1utis file: cache/cord-258888-amimzjee.json key: cord-258888-amimzjee authors: Ananth, Lakshmi; Hosamani, Pradeep title: Management of ENT Surgical Emergencies Amidst COVID-19 Lockdown: Our Experience in a Tertiary Referral Hospital date: 2020-07-23 journal: Indian J Otolaryngol Head Neck Surg DOI: 10.1007/s12070-020-01987-7 sha: doc_id: 258888 cord_uid: amimzjee file: cache/cord-257696-ybu772zw.json key: cord-257696-ybu772zw authors: Bartoletti, Michele; Marconi, Lorenzo; Scudeller, Luigia; Pancaldi, Livia; Tedeschi, Sara; Giannella, Maddalena; Rinaldi, Matteo; Bussini, Linda; Valentini, Ilaria; Ferravante, Anna Filomena; Potalivo, Antonella; Marchionni, Elisa; Fornaro, Giacomo; Pascale, Renato; Pasquini, Zeno; Puoti, Massimo; Merli, Marco; Barchiesi, Francesco; Volpato, Francesca; Rubin, Arianna; Saracino, Annalisa; Tonetti, Tommaso; Gaibani, Paolo; Ranieri, Vito Marco; Viale, Pierluigi; Cristini, Francesco title: Efficacy of corticosteroid treatment for hospitalized patients with severe COVID-19: a multicenter study date: 2020-09-22 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2020.09.014 sha: doc_id: 257696 cord_uid: ybu772zw file: cache/cord-258315-yt1ytasw.json key: cord-258315-yt1ytasw authors: Kato, Hideaki; Shimizu, Hiroyuki; Shibue, Yasushi; Hosoda, Tomohiro; Iwabuchi, Keisuke; Nagamine, Kotaro; Saito, Hiroki; Sawada, Reimin; Oishi, Takayuki; Tsukiji, Jun; Fujita, Hiroyuki; Furuya, Ryosuke; Masuda, Makoto; Akasaka, Osamu; Ikeda, Yu; Sakamoto, Mitsuo; Sakai, Kazuya; Uchiyama, Munehito; Watanabe, Hiroki; Yamaguchi, Nobuhiro; Higa, Ryoko; Sasaki, Akiko; Tanaka, Katsuaki; Toyoda, Yukitoshi; Hamanaka, Shinsuke; Miyazawa, Naoki; Shimizu, Atsuko; Fukase, Fumie; Iwai, Shunsuke; Komase, Yuko; Kawasaki, Tsutomu; Nagata, Isao; Nakayama, Yusuke; Takei, Tetsuhiro; Kimura, Katsuo; Kunisaki, Reiko; Kudo, Makoto; Takeuchi, Ichiro; Nakajima, Hideaki title: Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship date: 2020-05-13 journal: J Infect Chemother DOI: 10.1016/j.jiac.2020.05.005 sha: doc_id: 258315 cord_uid: yt1ytasw file: cache/cord-258402-9s57thvn.json key: cord-258402-9s57thvn authors: Dabas, Vineet; Bhatia, Nishant; Goel, Akash; Yadav, Vedpal; Bajaj, Vineet; Kumar, Vinod title: Management of Orthopaedic Accidental Emergencies Amidst COVID-19 Pandemic: Our Experience in Preparing to Live with Corona date: 2020-09-10 journal: Indian J Orthop DOI: 10.1007/s43465-020-00252-x sha: doc_id: 258402 cord_uid: 9s57thvn file: cache/cord-258758-sz8chn5e.json key: cord-258758-sz8chn5e authors: Resch, Tim; Vogt, Katja; Md, Nikolaj Eldrup. title: Atypical COVID -19 presentation in patient undergoing staged TAAA repair date: 2020-05-16 journal: J Vasc Surg Cases Innov Tech DOI: 10.1016/j.jvscit.2020.05.001 sha: doc_id: 258758 cord_uid: sz8chn5e file: cache/cord-259801-xuvcrvo2.json key: cord-259801-xuvcrvo2 authors: Koch, Christian A.; Vita, Roberto; Benvenga, Salvatore title: The Various Faces of Hyperthyroidism date: 2020-06-05 journal: J Clin Transl Endocrinol DOI: 10.1016/j.jcte.2020.100229 sha: doc_id: 259801 cord_uid: xuvcrvo2 file: cache/cord-259229-e8m8m4ut.json key: cord-259229-e8m8m4ut authors: Samidurai, Arun; Das, Anindita title: Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic Strategies date: 2020-09-16 journal: Int J Mol Sci DOI: 10.3390/ijms21186790 sha: doc_id: 259229 cord_uid: e8m8m4ut file: cache/cord-258133-zsweppku.json key: cord-258133-zsweppku authors: Fischer, M.; Coogan, A.N.; Faltraco, F.; Thome, J. title: COVID-19 paranoia in a patient suffering from schizophrenic psychosis – a case report date: 2020-04-17 journal: Psychiatry Res DOI: 10.1016/j.psychres.2020.113001 sha: doc_id: 258133 cord_uid: zsweppku file: cache/cord-258128-qtmjgrml.json key: cord-258128-qtmjgrml authors: Mirjalili, Mahtabalsadat; Shafiekhani, Mojtaba; Vazin, Afsaneh title: Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen date: 2020-07-03 journal: Ther Clin Risk Manag DOI: 10.2147/tcrm.s256246 sha: doc_id: 258128 cord_uid: qtmjgrml file: cache/cord-258930-60yn4hg7.json key: cord-258930-60yn4hg7 authors: D’Amico, Ferdinando; Peyrin-Biroulet, Laurent; Danese, Silvio title: Inflammatory bowel diseases and COVID-19: the invisible enemy date: 2020-04-16 journal: Gastroenterology DOI: 10.1053/j.gastro.2020.04.032 sha: doc_id: 258930 cord_uid: 60yn4hg7 file: cache/cord-259448-deya8dwn.json key: cord-259448-deya8dwn authors: Li, Caixia; Hu, Xiao; Li, Leilei; Li, Jin‐hui title: Differential microRNA expression in the peripheral blood from human patients with COVID‐19 date: 2020-09-22 journal: J Clin Lab Anal DOI: 10.1002/jcla.23590 sha: doc_id: 259448 cord_uid: deya8dwn file: cache/cord-259699-48jg7ci7.json key: cord-259699-48jg7ci7 authors: González-Calatayud, Dra Mariel; Vargas-Ábrego, Dr Benito; Gutiérrez-Uvalle, Dra Gabriela; López-Romero, Dra Sandra C.; Gabriel González-Pérez, Dr Luis; Alberto Carranco Martínez, Dr José; Raful Zacarías Ezzat, Dr Jed; Gracida Mancilla, Dr Noé I. title: Observational study of the suspected or confirmed cases of sars COV-2 infection needing emergency surgical intervention during the first months of the pandemic in a third level hospital: Case series date: 2020-10-24 journal: Ann Med Surg (Lond) DOI: 10.1016/j.amsu.2020.10.038 sha: doc_id: 259699 cord_uid: 48jg7ci7 file: cache/cord-258498-0mvxwo3w.json key: cord-258498-0mvxwo3w authors: Shah, Saleha title: COVID-19 and paediatric dentistry- traversing the challenges. A narrative review date: 2020-08-21 journal: Ann Med Surg (Lond) DOI: 10.1016/j.amsu.2020.08.007 sha: doc_id: 258498 cord_uid: 0mvxwo3w file: cache/cord-258916-jbdz1pk0.json key: cord-258916-jbdz1pk0 authors: Andreae, MH; Dudak, A; Cherian, V; Dhar, P; Dalal, PG; Po, W; Pilipovic, M; Shah, B; Hazard, W; Rodgers, DL; Sinz, EH title: Data and Debriefing Observations on Healthcare Simulation to Prepare for the COVID-19 Pandemic: Healthcare Simulation for COVID-19 date: 2020-07-15 journal: Data Brief DOI: 10.1016/j.dib.2020.106028 sha: doc_id: 258916 cord_uid: jbdz1pk0 file: cache/cord-259204-27t269pd.json key: cord-259204-27t269pd authors: Grimaldi, D.; Aissaoui, N.; Blonz, G.; Carbutti, G.; Courcelle, R.; Gaudry, S.; D'Hondt, A.; Higny, J.; Horlait, G.; Hraiech, S.; Lefebvre, L.; Lejeune, F.; Ly, A.; Piagnerelli, M.; Sauneuf, B.; Serck, N.; Soumagne, T.; Szychowiak, P.; Textoris, J.; Vandenbunder, B.; Vinsonneau, C.; Lascarrou, J. B. title: Characteristics and outcomes of Acute Respiratory Distress Syndrome related to COVID-19 in Belgian and French Intensive Care Units according to antiviral strategies. The COVADIS multicenter observational study. date: 2020-07-07 journal: nan DOI: 10.1101/2020.06.28.20141911 sha: doc_id: 259204 cord_uid: 27t269pd file: cache/cord-259767-x9s8qprc.json key: cord-259767-x9s8qprc authors: Harwayne-Gidansky, Ilana; Panesar, Rahul; Maa, Tensing title: Recent Advances in Simulation for Pediatric Critical Care Medicine date: 2020-08-28 journal: Curr Pediatr Rep DOI: 10.1007/s40124-020-00226-5 sha: doc_id: 259767 cord_uid: x9s8qprc file: cache/cord-259984-csdf1a69.json key: cord-259984-csdf1a69 authors: Raffiq, Azman; Seng, Liew Boon; San, Lim Swee; Zakaria, Zaitun; Yee, Ang Song; Fitzrol, Diana Noma; Hassan, Wan Mohd Nazaruddin Wan; Idris, Zamzuri; Ghani, Abdul Rahman Izaini; Rosman, Azmin Kass; Abdullah, Jafri Malin title: COVID-19 Pandemic and Its Impact on Neurosurgery Practice in Malaysia: Academic Insights, Clinical Experience and Protocols from March till August 2020 date: 2020-10-27 journal: Malays J Med Sci DOI: 10.21315/mjms2020.27.5.14 sha: doc_id: 259984 cord_uid: csdf1a69 file: cache/cord-260105-ckh8jp9e.json key: cord-260105-ckh8jp9e authors: Ñamendys-Silva, Silvio A title: Respiratory support for patients with COVID-19 infection date: 2020-04-30 journal: The Lancet Respiratory Medicine DOI: 10.1016/s2213-2600(20)30110-7 sha: doc_id: 260105 cord_uid: ckh8jp9e file: cache/cord-259747-sl9q63oc.json key: cord-259747-sl9q63oc authors: Remmelink, Myriam; De Mendonça, Ricardo; D’Haene, Nicky; De Clercq, Sarah; Verocq, Camille; Lebrun, Laetitia; Lavis, Philomène; Racu, Marie-Lucie; Trépant, Anne-Laure; Maris, Calliope; Rorive, Sandrine; Goffard, Jean-Christophe; De Witte, Olivier; Peluso, Lorenzo; Vincent, Jean-Louis; Decaestecker, Christine; Taccone, Fabio Silvio; Salmon, Isabelle title: Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients date: 2020-08-12 journal: Crit Care DOI: 10.1186/s13054-020-03218-5 sha: doc_id: 259747 cord_uid: sl9q63oc file: cache/cord-259073-dixskemz.json key: cord-259073-dixskemz authors: Ward, Christine F.; Figiel, Gary S.; McDonald, William M. title: Altered Mental Status as a Novel Initial Clinical Presentation for COVID-19 Infection in the Elderly date: 2020-05-15 journal: Am J Geriatr Psychiatry DOI: 10.1016/j.jagp.2020.05.013 sha: doc_id: 259073 cord_uid: dixskemz file: cache/cord-259969-q65k590s.json key: cord-259969-q65k590s authors: Kösters, Katrin; Schwarzer, Sitha; Labuhn, Achim; Rübben, Albert; Yang, Sara; Hessler, Frank; Assaf, Chalid title: Cutaneous Vasculitis in a Patient With COVID-19 date: 2020-10-05 journal: Open Forum Infect Dis DOI: 10.1093/ofid/ofaa474 sha: doc_id: 259969 cord_uid: q65k590s file: cache/cord-260456-kjmab3og.json key: cord-260456-kjmab3og authors: Hegde, Shruti; Yesodharan, Gemini; Tedrow, John; Goldman, Alena title: Massive Pulmonary Embolism Complicating Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report date: 2020-10-28 journal: Case Rep Crit Care DOI: 10.1155/2020/8875330 sha: doc_id: 260456 cord_uid: kjmab3og file: cache/cord-260503-yq4dtf8n.json key: cord-260503-yq4dtf8n authors: SAMARANAYAKE, LAKSHMAN P.; PEIRIS, MALIK title: Severe acute respiratory syndrome and dentistry A retrospective view date: 2004-09-30 journal: The Journal of the American Dental Association DOI: 10.14219/jada.archive.2004.0405 sha: doc_id: 260503 cord_uid: yq4dtf8n file: cache/cord-259907-yqmi0cqy.json key: cord-259907-yqmi0cqy authors: Maxwell, Cynthia; McGeer, Alison; Young Tai, Kin Fan; Sermer, Mathew; Farine, Dan; Basso, Melanie; Delisle, Marie-France; Hudon, Lynda; Menticoglou, Savas; Mundle, William; Ouellet, Annie; Yudin, Mark H.; Boucher, Marc; Castillo, Eliana; Cormier, Beatrice; Gruslin, Andrée; Money, Deborah M.; Murphy, Kellie; Paquet, Caroline; Steenbeek, Audrey; Van Eyk, Nancy; van Schalkwyk, Julie; Wong, Thomas title: Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) No. 225, April 2009 date: 2009-10-31 journal: International Journal of Gynecology & Obstetrics DOI: 10.1016/j.ijgo.2009.05.006 sha: doc_id: 259907 cord_uid: yqmi0cqy file: cache/cord-260525-bohv78hi.json key: cord-260525-bohv78hi authors: Mei, Yang; Weinberg, Samuel E.; Zhao, Lihui; Frink, Adam; Qi, Chao; Behdad, Amir; Ji, Peng title: Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza date: 2020-07-31 journal: EClinicalMedicine DOI: 10.1016/j.eclinm.2020.100475 sha: doc_id: 260525 cord_uid: bohv78hi file: cache/cord-259329-8pta6o6a.json key: cord-259329-8pta6o6a authors: Haimovich, Adrian; Ravindra, Neal G.; Stoytchev, Stoytcho; Young, H. Patrick; PerryWilson, Francis; van Dijk, David; Schulz, Wade L.; Taylor, R. Andrew title: Development and validation of the quick COVID-19 severity index (qCSI): a prognostic tool for early clinical decompensation date: 2020-07-21 journal: Ann Emerg Med DOI: 10.1016/j.annemergmed.2020.07.022 sha: doc_id: 259329 cord_uid: 8pta6o6a file: cache/cord-259585-mjtxiu0t.json key: cord-259585-mjtxiu0t authors: Occhipinti, Vincenzo; Pastorelli, Luca title: Challenges in the Care of IBD Patients During the CoViD-19 Pandemic: Report From a “Red Zone” Area in Northern Italy date: 2020-04-21 journal: Inflamm Bowel Dis DOI: 10.1093/ibd/izaa084 sha: doc_id: 259585 cord_uid: mjtxiu0t file: cache/cord-260215-gsnjlhjd.json key: cord-260215-gsnjlhjd authors: Dhanani, Jayesh; Fraser, John F.; Chan, Hak-Kim; Rello, Jordi; Cohen, Jeremy; Roberts, Jason A. title: Fundamentals of aerosol therapy in critical care date: 2016-10-07 journal: Crit Care DOI: 10.1186/s13054-016-1448-5 sha: doc_id: 260215 cord_uid: gsnjlhjd file: cache/cord-260037-ys62jrgw.json key: cord-260037-ys62jrgw authors: Jecker, Nancy S.; Dudzinski, Denise M.; Diekema, Douglas S.; Tonelli, Mark title: Ebola Virus Disease Ethics and Emergency Medical Response Policy date: 2015-09-30 journal: Chest DOI: 10.1378/chest.15-0135 sha: doc_id: 260037 cord_uid: ys62jrgw file: cache/cord-260083-c1r9zn43.json key: cord-260083-c1r9zn43 authors: Lucatelli, Pierleone; De Rubeis, Gianluca; Citone, Michele; Lucarelli, Nicola Maria; Pasqualini, Valerio; Sturiale, Mauro; Giuliani, Silvia; Rosati, Marzia; Ceccherini, Claudio; Corona, Mario; Mosconi, Cristina; Utili, Alice; Argirò, Renato title: Heparin-Related Major Bleeding in Covid-19-Positive Patient: Perspective from the Outbreak date: 2020-05-28 journal: Cardiovasc Intervent Radiol DOI: 10.1007/s00270-020-02532-3 sha: doc_id: 260083 cord_uid: c1r9zn43 file: cache/cord-260180-kojb8efv.json key: cord-260180-kojb8efv authors: Elsoukkary, Sarah S.; Mostyka, Maria; Dillard, Alicia; Berman, Diana R.; Ma, Lucy X.; Chadburn, Amy; Yantiss, Rhonda K.; Jessurun, Jose; Seshan, Surya V.; Borczuk, Alain C.; Salvatore, Steven P. title: Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience date: 2020-09-17 journal: Pathobiology DOI: 10.1159/000511325 sha: doc_id: 260180 cord_uid: kojb8efv file: cache/cord-259411-434acu0h.json key: cord-259411-434acu0h authors: Aljehani, Faisal A.; Funke, Katalina; Hermayer, Kathie L. title: Inpatient Diabetes and Hyperglycemia Management Protocol in the COVID-19 Era date: 2020-07-06 journal: Am J Med Sci DOI: 10.1016/j.amjms.2020.07.005 sha: doc_id: 259411 cord_uid: 434acu0h file: cache/cord-260630-vvpzp73r.json key: cord-260630-vvpzp73r authors: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 journal: Clin Infect Dis DOI: 10.1086/432019 sha: doc_id: 260630 cord_uid: vvpzp73r file: cache/cord-260232-98gtlad6.json key: cord-260232-98gtlad6 authors: Chenna, Avantika; Konala, Venu Madhav; Bose, Subhasish; Roy, Sasmit; Madhira, Bhaskar Reddy; Gayam, Vijay; Naramala, Srikanth; Adapa, Sreedhar title: Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade date: 2020-06-29 journal: Case Rep Nephrol DOI: 10.1155/2020/8811931 sha: doc_id: 260232 cord_uid: 98gtlad6 file: cache/cord-260700-u12aa739.json key: cord-260700-u12aa739 authors: Kainulainen, Leena; Vuorinen, Tytti; Rantakokko-Jalava, Kaisu; Österback, Riikka; Ruuskanen, Olli title: Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia date: 2010-06-10 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2010.04.016 sha: doc_id: 260700 cord_uid: u12aa739 file: cache/cord-260274-c3586tp6.json key: cord-260274-c3586tp6 authors: Somers, Emily C; Eschenauer, Gregory A; Troost, Jonathan P; Golob, Jonathan L; Gandhi, Tejal N; Wang, Lu; Zhou, Nina; Petty, Lindsay A; Baang, Ji Hoon; Dillman, Nicholas O; Frame, David; Gregg, Kevin S; Kaul, Dan R; Nagel, Jerod; Patel, Twisha S; Zhou, Shiwei; Lauring, Adam S; Hanauer, David A; Martin, Emily; Sharma, Pratima; Fung, Christopher M; Pogue, Jason M title: Tocilizumab for treatment of mechanically ventilated patients with COVID-19 date: 2020-07-11 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa954 sha: doc_id: 260274 cord_uid: c3586tp6 file: cache/cord-261062-9zhe3ejy.json key: cord-261062-9zhe3ejy authors: Zhu, Shu-Ting; Tao, Fang-Yi; Xu, Jing-Hong; Liao, Shu-Sheng; Shen, Chuan-Li; Shi, Bin-Bin; Liang, Zeng-Hui; Li, Qiao title: Utility of Point-of-Care Lung Ultrasound for Clinical Classification of COVID-19 date: 2020-09-21 journal: Ultrasound Med Biol DOI: 10.1016/j.ultrasmedbio.2020.09.010 sha: doc_id: 261062 cord_uid: 9zhe3ejy file: cache/cord-260679-tm1s6wvj.json key: cord-260679-tm1s6wvj authors: Lim, Wei Shen title: Pneumonia—Overview date: 2020-05-20 journal: Reference Module in Biomedical Sciences DOI: 10.1016/b978-0-12-801238-3.11636-8 sha: doc_id: 260679 cord_uid: tm1s6wvj file: cache/cord-260605-smkr7b15.json key: cord-260605-smkr7b15 authors: Vestby, Lene K.; Grønseth, Torstein; Simm, Roger; Nesse, Live L. title: Bacterial Biofilm and its Role in the Pathogenesis of Disease date: 2020-02-03 journal: Antibiotics (Basel) DOI: 10.3390/antibiotics9020059 sha: doc_id: 260605 cord_uid: smkr7b15 file: cache/cord-031907-ilhr3iu5.json key: cord-031907-ilhr3iu5 authors: nan title: ISEV2020 Abstract Book date: 2020-07-15 journal: nan DOI: 10.1080/20013078.2020.1784511 sha: doc_id: 31907 cord_uid: ilhr3iu5 file: cache/cord-260224-1aeqe7fh.json key: cord-260224-1aeqe7fh authors: Passerini, Matteo; Terzi, Roberta; Piscaglia, Marco; Passerini, Simone; Piconi, Stefania title: Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak date: 2020-05-23 journal: Cureus DOI: 10.7759/cureus.8254 sha: doc_id: 260224 cord_uid: 1aeqe7fh file: cache/cord-260762-1kuj5dzz.json key: cord-260762-1kuj5dzz authors: Elledge, Christen R.; Beriwal, Sushil; Chargari, Cyrus; Chopra, Supriya; Erickson, Beth A.; Gaffney, David K.; Jhingran, Anuja; Klopp, Ann H.; Small, William; Yashar, Catheryn M.; Viswanathan, Akila N. title: Radiation therapy for gynecologic malignancies during the COVID-19 pandemic: International expert consensus recommendations date: 2020-06-15 journal: Gynecol Oncol DOI: 10.1016/j.ygyno.2020.06.486 sha: doc_id: 260762 cord_uid: 1kuj5dzz file: cache/cord-261006-2xh3f07i.json key: cord-261006-2xh3f07i authors: Dong, Zhiyong; Zhang, Peng; Zhu, Jiangfan; Bai, Jie; Parmar, Chetan; Chen, Wenhui; Hu, Ruixiang; Wang, Jianxue; Chong, Tsz Hong; Jiang, Shuwen; Yang, Wah; Gao, Lilian; Chen, Xiaomei; Yang, Jingge; Xia, Zefeng; Tao, Kaixiong; Wang, Cunchuan title: Recommendations to Manage Patients for Bariatric Surgery in the COVID-19 Pandemic: Experience from China date: 2020-06-06 journal: Obes Surg DOI: 10.1007/s11695-020-04741-8 sha: doc_id: 261006 cord_uid: 2xh3f07i file: cache/cord-260871-dtn5t8ka.json key: cord-260871-dtn5t8ka authors: Silva, Marcus Tulius T.; Lima, Marco; Araujo, Abelardo Q.-C. title: SARS-CoV-2: Should We Be Concerned about the Nervous System? date: 2020-07-17 journal: Am J Trop Med Hyg DOI: 10.4269/ajtmh.20-0447 sha: doc_id: 260871 cord_uid: dtn5t8ka file: cache/cord-260980-tyf3fuz9.json key: cord-260980-tyf3fuz9 authors: Lorenzo Villalba, Noel; Maouche, Yasmine; Alonso Ortiz, Maria Belen; Cordoba Sosa, Zaida; Chahbazian, Jean Baptiste; Syrovatkova, Aneska; Pertoldi, Pierre; Andres, Emmanuel; Zulfiqar, Abrar-Ahmad title: Anosmia and Dysgeusia in the Absence of Other Respiratory Diseases: Should COVID-19 Infection Be Considered? date: 2020-04-03 journal: Eur J Case Rep Intern Med DOI: 10.12890/2020_001641 sha: doc_id: 260980 cord_uid: tyf3fuz9 file: cache/cord-260981-647wfa8z.json key: cord-260981-647wfa8z authors: Torti, Lorenza; Maffei, Laura; Sorrentino, Francesco; De Fabritiis, Paolo; Miceli, Rossella; Abruzzese, Elisabetta title: Impact of SARS CoV-2 in Hemoglobinopathies with Immune Disfunction and Epidemiology. A Protective Mechanism from Beta Chain Hemoglobin Defects? date: 2020-07-01 journal: Mediterr J Hematol Infect Dis DOI: 10.4084/mjhid.2020.052 sha: doc_id: 260981 cord_uid: 647wfa8z file: cache/cord-259848-0thzmh7k.json key: cord-259848-0thzmh7k authors: Sutera, Diana; Mazza, Francesca; Pajno, Giovanni Battista; Spagnolo, Alessandra; Gallizzi, Romina title: Management of Pediatric Rheumatological Diseases During the Outbreak of COVID-19: Our Experience date: 2020-07-01 journal: Mediterr J Hematol Infect Dis DOI: 10.4084/mjhid.2020.049 sha: doc_id: 259848 cord_uid: 0thzmh7k file: cache/cord-261151-27ocvgnw.json key: cord-261151-27ocvgnw authors: Becker, Jessica E.; Smith, Joshua R.; Hazen, Eric P. title: Pediatric Consultation-Liaison Psychiatry: An Update and Review date: 2020-04-25 journal: Psychosomatics DOI: 10.1016/j.psym.2020.04.015 sha: doc_id: 261151 cord_uid: 27ocvgnw file: cache/cord-261410-kb91eagd.json key: cord-261410-kb91eagd authors: Park, Ji Young; Kim, Bong-Joon; Lee, Eun Jung; Park, Kwi Sung; Park, Hee Sun; Jung, Sung Soo; Kim, Ju Ock title: Clinical Features and Courses of Adenovirus Pneumonia in Healthy Young Adults during an Outbreak among Korean Military Personnel date: 2017-01-23 journal: PLoS One DOI: 10.1371/journal.pone.0170592 sha: doc_id: 261410 cord_uid: kb91eagd file: cache/cord-261383-izd1vn6f.json key: cord-261383-izd1vn6f authors: Oleynick, Christopher title: Symptoms of Pleurisy as the Initial Presentation of COVID-19 date: 2020-07-24 journal: Am J Case Rep DOI: 10.12659/ajcr.925775 sha: doc_id: 261383 cord_uid: izd1vn6f file: cache/cord-260119-pgu2crhs.json key: cord-260119-pgu2crhs authors: Golledge, Jonathan; Fernando, Malindu; Lazzarini, Peter; Najafi, Bijan; G. Armstrong, David title: The Potential Role of Sensors, Wearables and Telehealth in the Remote Management of Diabetes-Related Foot Disease date: 2020-08-13 journal: Sensors (Basel) DOI: 10.3390/s20164527 sha: doc_id: 260119 cord_uid: pgu2crhs file: cache/cord-260854-v7wgb6mr.json key: cord-260854-v7wgb6mr authors: Colafrancesco, Serena; Alessandri, Cristiano; Conti, Fabrizio; Priori, Roberta title: COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome? date: 2020-05-05 journal: Autoimmun Rev DOI: 10.1016/j.autrev.2020.102573 sha: doc_id: 260854 cord_uid: v7wgb6mr file: cache/cord-261470-sqxdwu6j.json key: cord-261470-sqxdwu6j authors: Weichmann, Franziska; Rohdewald, Peter title: Projected supportive effects of Pycnogenol® in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection date: 2020-10-09 journal: Int J Antimicrob Agents DOI: 10.1016/j.ijantimicag.2020.106191 sha: doc_id: 261470 cord_uid: sqxdwu6j file: cache/cord-261485-0ke5nqy0.json key: cord-261485-0ke5nqy0 authors: Sabir, A. M.; Alvi, I. A.; Alharbi, M.; Basabrain, A.; Aljundi, M.; Almohammadi, G.; Almuairfi, Z.; Alharbi, R. title: Effects of Anticoagulants and Corticosteroids therapy in patients affected by severe COVID-19 Pneumonia date: 2020-06-29 journal: nan DOI: 10.1101/2020.06.22.20134957 sha: doc_id: 261485 cord_uid: 0ke5nqy0 file: cache/cord-261801-va2e029z.json key: cord-261801-va2e029z authors: Hoffman, Pamela E.; London, Yollanda R.; Weerakoon, Tasmeen S.; DeLucia, Nichole L. title: Rapidly scaling video visits during COVID-19: The ethos of virtual care at Yale Medicine date: 2020-10-01 journal: Healthc (Amst) DOI: 10.1016/j.hjdsi.2020.100482 sha: doc_id: 261801 cord_uid: va2e029z file: cache/cord-261025-y49su5uc.json key: cord-261025-y49su5uc authors: Sampathkumar, Priya; Temesgen, Zelalem; Smith, Thomas F.; Thompson, Rodney L. title: SARS: Epidemiology, Clinical Presentation, Management, and Infection Control Measures date: 2003-07-31 journal: Mayo Clinic Proceedings DOI: 10.4065/78.7.882 sha: doc_id: 261025 cord_uid: y49su5uc file: cache/cord-261311-j6bmgmhz.json key: cord-261311-j6bmgmhz authors: Parreiras Martins, Maria Auxiliadora; Fonseca de Medeiros, Amanda; Dias Carneiro de Almeida, Claudmeire; Moreira Reis, Adriano Max title: Preparedness of pharmacists to respond to the emergency of the COVID-19 pandemic in Brazil: a comprehensive overview date: 2020-07-31 journal: Drugs Ther Perspect DOI: 10.1007/s40267-020-00761-7 sha: doc_id: 261311 cord_uid: j6bmgmhz file: cache/cord-261246-m40kwgcg.json key: cord-261246-m40kwgcg authors: Chen, Nanshan; Zhou, Min; Dong, Xuan; Qu, Jieming; Gong, Fengyun; Han, Yang; Qiu, Yang; Wang, Jingli; Liu, Ying; Wei, Yuan; Xia, Jia'an; Yu, Ting; Zhang, Xinxin; Zhang, Li title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study date: 2020-01-30 journal: Lancet DOI: 10.1016/s0140-6736(20)30211-7 sha: doc_id: 261246 cord_uid: m40kwgcg file: cache/cord-261380-xms5su6w.json key: cord-261380-xms5su6w authors: Rahmani, Hamid; Davoudi-Monfared, Effat; Nourian, Anahid; Khalili, Hossein; Hajizadeh, Nooshin; zarei Jalalabadi, Narjes; Reza Fazeli, Mohammad; Ghazaeian, Monireh; Saeed Yekaninejad, Mir title: Interferon β-1b in treatment of severe COVID-19: a randomized clinical trial date: 2020-08-24 journal: Int Immunopharmacol DOI: 10.1016/j.intimp.2020.106903 sha: doc_id: 261380 cord_uid: xms5su6w file: cache/cord-260857-oxxle915.json key: cord-260857-oxxle915 authors: Samuel, Sharmeen; Friedman, Richard A.; Sharma, Chetan; Ganigara, Madhusudan; Mitchell, Elizabeth; Schleien, Charles; Blaufox, Andrew D. title: INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc). date: 2020-07-01 journal: Heart Rhythm DOI: 10.1016/j.hrthm.2020.06.033 sha: doc_id: 260857 cord_uid: oxxle915 file: cache/cord-261980-bm0benu2.json key: cord-261980-bm0benu2 authors: Cox, Mougnyan; Ramchand, Preethi; McCabe, Melissa; Hoey, Colin; Lehmann, Jessica; Collinson, Randi; Kung, David; Pukenas, Bryan; Thacker, Ike; Layton, Kennith; Hurst, Robert W.; Sedora-Roman, Neda I. title: Neuroendovascular Treatment of Acute Stroke during Covid-19: A Guide from the Frontlines date: 2020-05-29 journal: J Radiol Nurs DOI: 10.1016/j.jradnu.2020.05.007 sha: doc_id: 261980 cord_uid: bm0benu2 file: cache/cord-261921-c97ygxq2.json key: cord-261921-c97ygxq2 authors: Souders, Colby P.; Zhao, Hanson; Ackerman, A. Lenore title: Considerations for Bedside Urologic Procedures in Patients with Severe Acute Respiratory Syndrome Coronavirus-2 date: 2020-04-24 journal: Urology DOI: 10.1016/j.urology.2020.04.066 sha: doc_id: 261921 cord_uid: c97ygxq2 file: cache/cord-261240-osbk041e.json key: cord-261240-osbk041e authors: Bermejo-Martin, Jesús F; Almansa, Raquel; Menéndez, Rosario; Mendez, Raúl; Kelvin, David J; Torres, Antoni title: Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection date: 2020-03-05 journal: J Infect DOI: 10.1016/j.jinf.2020.02.029 sha: doc_id: 261240 cord_uid: osbk041e file: cache/cord-261670-rd9uq6tc.json key: cord-261670-rd9uq6tc authors: Stringer, Kathleen A.; Puskarich, Michael A.; Kenes, Michael T.; Dickson, Robert P. title: COVID‐19: The Uninvited Guest in the Intensive Care Unit — Implications for Pharmacotherapy date: 2020-05-04 journal: Pharmacotherapy DOI: 10.1002/phar.2394 sha: doc_id: 261670 cord_uid: rd9uq6tc file: cache/cord-261736-jlwctmxw.json key: cord-261736-jlwctmxw authors: Marchand, Geneviève; Duchaine, Caroline; Lavoie, Jacques; Veillette, Marc; Cloutier, Yves title: Bacteria emitted in ambient air during bronchoscopy—a risk to health care workers? date: 2016-12-01 journal: Am J Infect Control DOI: 10.1016/j.ajic.2016.04.241 sha: doc_id: 261736 cord_uid: jlwctmxw file: cache/cord-261455-uejtwgar.json key: cord-261455-uejtwgar authors: Roschewski, Mark; Lionakis, Michail S.; Sharman, Jeff P.; Roswarski, Joseph; Goy, Andre; Monticelli, M. Andrew; Roshon, Michael; Wrzesinski, Stephen H.; Desai, Jigar V.; Zarakas, Marissa A.; Collen, Jacob; Rose, Keith; Hamdy, Ahmed; Izumi, Raquel; Wright, George W.; Chung, Kevin K.; Baselga, Jose; Staudt, Louis M.; Wilson, Wyndham H. title: Inhibition of Bruton tyrosine kinase in patients with severe COVID-19 date: 2020-06-05 journal: Sci Immunol DOI: 10.1126/sciimmunol.abd0110 sha: doc_id: 261455 cord_uid: uejtwgar file: cache/cord-261856-i1e0uj0s.json key: cord-261856-i1e0uj0s authors: Heffner, John E; Highland, Kristin B title: Chronic obstructive pulmonary disease in geriatric critical care date: 2005-03-04 journal: Crit Care Clin DOI: 10.1016/s0749-0704(03)00054-x sha: doc_id: 261856 cord_uid: i1e0uj0s file: cache/cord-262412-bs7quwov.json key: cord-262412-bs7quwov authors: Kaya, Gürkan; Kaya, Aysin; Saurat, Jean-Hilaire title: Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature date: 2020-06-30 journal: Dermatopathology (Basel) DOI: 10.3390/dermatopathology7010002 sha: doc_id: 262412 cord_uid: bs7quwov file: cache/cord-262068-9ixq8hwb.json key: cord-262068-9ixq8hwb authors: Gottardi, Andrea De; Fratila, Corneliu; Bertoli, Raffaela; Cerny, Andreas; Magenta, Lorenzo; Gianella, Pietro; Majno-Hurst, Pietro; Ceschi, Alessandro; Vanini, Gianluca; Bernasconi, Enos title: Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection date: 2020-06-10 journal: Clin Res Hepatol Gastroenterol DOI: 10.1016/j.clinre.2020.05.014 sha: doc_id: 262068 cord_uid: 9ixq8hwb file: cache/cord-262236-1lilrqts.json key: cord-262236-1lilrqts authors: Capone, Stephen; Abramyan, Shogik; Ross, Brent; Rosenberg, Joshua; Zeibeq, John; Vasudevan, Viswanath; Samad, Reza; Gerolemou, Louis; Pinelis, Evgeny; Gasperino, James; Orsini, Jose title: Characterization of Critically Ill COVID-19 Patients at a Brooklyn Safety-Net Hospital date: 2020-08-17 journal: Cureus DOI: 10.7759/cureus.9809 sha: doc_id: 262236 cord_uid: 1lilrqts file: cache/cord-022940-atbjwpo5.json key: cord-022940-atbjwpo5 authors: nan title: Poster Sessions date: 2016-09-07 journal: FEBS J DOI: 10.1111/febs.13808 sha: doc_id: 22940 cord_uid: atbjwpo5 file: cache/cord-262454-bccrvapy.json key: cord-262454-bccrvapy authors: Szente Fonseca, Silvia Nunes; Queiroz de Sousa, Anastasio; Wolkoff, Alexandre Giandoni; Moreira, Marcelo Sampaio; Pinto, Bruno Castro; Valente Takeda, Christianne Fernandes; Rebouças, Eduardo; Vasconcellos Abdon, Ana Paula; Nascimento, Anderson L.A.; Risch, Harvey A. title: Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative Analysis date: 2020-10-31 journal: Travel Med Infect Dis DOI: 10.1016/j.tmaid.2020.101906 sha: doc_id: 262454 cord_uid: bccrvapy file: cache/cord-262339-e2ayh108.json key: cord-262339-e2ayh108 authors: Bohner, Lauren; Maus, Melanie; Kleinheinz, Johannes; Hanisch, Marcel title: 2019-nCoV: Measures Adopted at the Departments of Oral Surgery and Radiology during the Period of an Uncontrolled Transmission Increase date: 2020-06-08 journal: Dent J (Basel) DOI: 10.3390/dj8020057 sha: doc_id: 262339 cord_uid: e2ayh108 file: cache/cord-262150-j72jbohi.json key: cord-262150-j72jbohi authors: Cheng, Chun-Hung; Kuo, Yong-Hong title: RFID analytics for hospital ward management date: 2015-10-23 journal: Flex Serv Manuf J DOI: 10.1007/s10696-015-9230-6 sha: doc_id: 262150 cord_uid: j72jbohi file: cache/cord-262626-yk4e737w.json key: cord-262626-yk4e737w authors: Favaloro, Emmanuel J.; Lippi, Giuseppe title: Recommendations for Minimal Laboratory Testing Panels in Patients with COVID-19: Potential for Prognostic Monitoring date: 2020-04-12 journal: Semin Thromb Hemost DOI: 10.1055/s-0040-1709498 sha: doc_id: 262626 cord_uid: yk4e737w file: cache/cord-262824-xgf5v1ok.json key: cord-262824-xgf5v1ok authors: Castillo, Felipe title: On Redeployment to Palliative Care date: 2020-11-10 journal: Acad Psychiatry DOI: 10.1007/s40596-020-01355-1 sha: doc_id: 262824 cord_uid: xgf5v1ok file: cache/cord-261941-xf1k5uj1.json key: cord-261941-xf1k5uj1 authors: Stackhouse, Robin A. title: Severe acute respiratory syndrome and tuberculosis date: 2005-03-01 journal: Anesthesiol Clin North Am DOI: 10.1016/j.atc.2004.06.002 sha: doc_id: 261941 cord_uid: xf1k5uj1 file: cache/cord-262796-syu4wbpi.json key: cord-262796-syu4wbpi authors: Wei, Xiao-Shan; Wang, Xu; Niu, Yi-Ran; Ye, Lin-Lin; Peng, Wen-Bei; Wang, Zi-Hao; Yang, Wei-Bing; Yang, Bo-Han; Zhang, Jian-Chu; Ma, Wan-Li; Wang, Xiao-Rong; Zhou, Qiong title: Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19 date: 2020-04-18 journal: Clin Gastroenterol Hepatol DOI: 10.1016/j.cgh.2020.04.030 sha: doc_id: 262796 cord_uid: syu4wbpi file: cache/cord-262780-ilu5oskk.json key: cord-262780-ilu5oskk authors: Sattui, Sebastian E.; Liew, Jean W.; Graef, Elizabeth R.; Coler-Reilly, Ariella; Berenbaum, Francis; Duarte-García, Alí; Harrison, Carly; Konig, Maximilian F.; Korsten, Peter; Putman, Michael S.; Robinson, Philip C.; Sirotich, Emily; Ugarte-Gil, Manuel F.; Webb, Kate; Young, Kristen J.; Kim, Alfred H.J.; Sparks, Jeffrey A. title: Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19 date: 2020-08-11 journal: Expert review of clinical immunology DOI: 10.1080/1744666x.2020.1792778 sha: doc_id: 262780 cord_uid: ilu5oskk file: cache/cord-262708-hctuxrw9.json key: cord-262708-hctuxrw9 authors: Ramachandra, C.; Sugoor, Pavan; Karjol, Uday; Arjunan, Ravi; Altaf, Syed; Halkud, Rajshekar; Krishnappa, R.; Chavan, Purushotham; Siddappa, K. T.; Shetty, Rathan; Pallavi, V. R.; Rathod, Praveen; Shobha, K.; Sabitha, K. S. title: Outcomes of Cancer Surgery During the COVID-19 Pandemic: Preparedness to Practising Continuous Cancer Care date: 2020-10-19 journal: Indian J Surg Oncol DOI: 10.1007/s13193-020-01250-z sha: doc_id: 262708 cord_uid: hctuxrw9 file: cache/cord-262729-qcijsyo6.json key: cord-262729-qcijsyo6 authors: Eichberg, Daniel G; Shah, Ashish H; Luther, Evan M; Menendez, Ingrid; Jimenez, Andrea; Perez-Dickens, Maggy; O’Phelan, Kristine H; Ivan, Michael E; Komotar, Ricardo J; Levi, Allan D title: Letter: Academic Neurosurgery Department Response to COVID-19 Pandemic: The University of Miami/Jackson Memorial Hospital Model date: 2020-04-11 journal: Neurosurgery DOI: 10.1093/neuros/nyaa118 sha: doc_id: 262729 cord_uid: qcijsyo6 file: cache/cord-262467-epqqd8n8.json key: cord-262467-epqqd8n8 authors: Chen, Jun; Lu, Hongzhou; Melino, Gerry; Boccia, Stefania; Piacentini, Mauro; Ricciardi, Walter; Wang, Ying; Shi, Yufang; Zhu, Tongyu title: COVID-19 infection: the China and Italy perspectives date: 2020-06-08 journal: Cell Death Dis DOI: 10.1038/s41419-020-2603-0 sha: doc_id: 262467 cord_uid: epqqd8n8 file: cache/cord-262954-saqo900k.json key: cord-262954-saqo900k authors: Esme, Mert; Koca, Meltem; Dikmeer, Ayse; Balci, Cafer; Ata, Naim; Dogu, Burcu Balam; Cankurtaran, Mustafa; Yilmaz, Meltem; Celik, Osman; Unal, Gulnihal Gokce; Ulgu, Mustafa Mahir; Birinci, Suayip title: Older Adults With Coronavirus Disease 2019; A Nationwide Study in Turkey date: 2020-09-01 journal: J Gerontol A Biol Sci Med Sci DOI: 10.1093/gerona/glaa219 sha: doc_id: 262954 cord_uid: saqo900k file: cache/cord-262518-a2ql8hib.json key: cord-262518-a2ql8hib authors: Fan, Peijin Esther Monica; Aloweni, Fazila; Lim, Shu Hui; Ang, Shin Yuh; Perera, Karen; Quek, Aik Huan; Quek, Hwee Koon Susan; Ayre, Tracy Carol title: Needs and concerns of patients in isolation care units - learnings from COVID-19: A reflection date: 2020-05-26 journal: World J Clin Cases DOI: 10.12998/wjcc.v8.i10.1763 sha: doc_id: 262518 cord_uid: a2ql8hib file: cache/cord-262551-hxhlhb5m.json key: cord-262551-hxhlhb5m authors: van der Gronde, Toon; Los, Leontien; Herremans, Arnoud; Oosting, Ronald; Zorzanelli, Rafaela; Pieters, Toine title: Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress date: 2020-05-06 journal: Front Psychiatry DOI: 10.3389/fpsyt.2020.00412 sha: doc_id: 262551 cord_uid: hxhlhb5m file: cache/cord-262928-l2bqcd0l.json key: cord-262928-l2bqcd0l authors: Guarisco, Gloria; Leonetti, Frida title: Covid-19 and diabesity: when a pandemia cross another pandemia date: 2020-07-14 journal: Eat Weight Disord DOI: 10.1007/s40519-020-00958-9 sha: doc_id: 262928 cord_uid: l2bqcd0l file: cache/cord-262973-mydn7ver.json key: cord-262973-mydn7ver authors: Zhang, Dekang; Li, Tao; Wang, Pei; Wang, Weidong; Feng, Mei; Li, Lintao; Jiang, Qinghua; Lan, Mei; Clara Orlandini, Lucia; Li, Jie; Lang, Jinyi title: Experts Consensus on Epidemic Prevention and Control in Radiotherapy Centers during the COVID-19 Outbreak: Experiences from Sichuan Province date: 2020-06-30 journal: Clin Transl Radiat Oncol DOI: 10.1016/j.ctro.2020.06.010 sha: doc_id: 262973 cord_uid: mydn7ver file: cache/cord-262784-r9gq2oan.json key: cord-262784-r9gq2oan authors: Tian, Suochen; Chang, Zhenqin; Wang, Yunxia; Wu, Min; Zhang, Wenming; Zhou, Guijie; Zou, Xiuli; Tian, Hui; Xiao, Tingfang; Xing, Junmin; Chen, Juan; Han, Jian; Ning, Kang; Wu, Tiejun title: Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China date: 2020-05-12 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00210 sha: doc_id: 262784 cord_uid: r9gq2oan file: cache/cord-263061-ocplcdiv.json key: cord-263061-ocplcdiv authors: Rivetti, Luigi; Mantovan, Roberto; Sitta, Nadir; Marinigh, Ricarda; Allocca, Giuseppe; Mohammed, Moemen; Pizzino, Fausto; Nucifora, Giuseppe title: Management of Pacemaker Implantation during COVID-19 Infection date: 2020-10-24 journal: Case Rep Cardiol DOI: 10.1155/2020/8833660 sha: doc_id: 263061 cord_uid: ocplcdiv file: cache/cord-262987-7h91n9ro.json key: cord-262987-7h91n9ro authors: Bin Traiki, Thamer A.; AlShammari, Sulaiman A.; AlAli, Mohammed N.; Aljomah, Nadia A.; Alhassan, Noura S.; Alkhayal, Khayal A.; Al-Obeed, Omar A.; Zubaidi, Ahmad M. title: Impact of COVID-19 pandemic on patient satisfaction and surgical outcomes: A retrospective and cross sectional study date: 2020-08-21 journal: Ann Med Surg (Lond) DOI: 10.1016/j.amsu.2020.08.020 sha: doc_id: 262987 cord_uid: 7h91n9ro file: cache/cord-262998-cugd2t1l.json key: cord-262998-cugd2t1l authors: Singh, Vishwendra; Lehl, Gurvanit K; Talwar, Manjit; Luthra, Ankur title: The novel coronavirus and challenges for general and paediatric dentists date: 2020-05-02 journal: Occup Med (Lond) DOI: 10.1093/occmed/kqaa055 sha: doc_id: 262998 cord_uid: cugd2t1l file: cache/cord-263055-4f25h9l4.json key: cord-263055-4f25h9l4 authors: Fogarty, Helen; Townsend, Liam; Ni Cheallaigh, Cliona; Bergin, Colm; Martin‐Loeches, Ignacio; Browne, Paul; Bacon, Christopher L.; Gaule, Richard; Gillett, Alexander; Byrne, Mary; Ryan, Kevin; O'Connell, Niamh; O'Sullivan, Jamie M.; Conlon, Niall; O'Donnell, James S. title: More on COVID‐19 coagulopathy in Caucasian patients date: 2020-05-25 journal: Br J Haematol DOI: 10.1111/bjh.16791 sha: doc_id: 263055 cord_uid: 4f25h9l4 file: cache/cord-263292-qjfe2t9v.json key: cord-263292-qjfe2t9v authors: Sansone, A.; Mollaioli, D.; Ciocca, G.; Limoncin, E.; Colonnello, E.; Vena, W.; Jannini, E. A. title: Addressing male sexual and reproductive health in the wake of COVID-19 outbreak date: 2020-07-13 journal: J Endocrinol Invest DOI: 10.1007/s40618-020-01350-1 sha: doc_id: 263292 cord_uid: qjfe2t9v file: cache/cord-263285-89zqgqx1.json key: cord-263285-89zqgqx1 authors: Sethi, Sanjum S.; Zilinyi, Robert; Green, Philip; Eisenberger, Andrew; Brodie, Daniel; Agerstrand, Cara; Takeda, Koji; Kirtane, Ajay J.; Parikh, Sahil A.; Rosenzweig, Erika B. title: Right Ventricular Clot in Transit in COVID-19: Implications for the Pulmonary Embolism Response Team date: 2020-05-29 journal: JACC Case Rep DOI: 10.1016/j.jaccas.2020.05.034 sha: doc_id: 263285 cord_uid: 89zqgqx1 file: cache/cord-263214-h6lkvlj3.json key: cord-263214-h6lkvlj3 authors: Bassi, Massimiliano; Anile, Marco; Pecoraro, Ylenia; Ruberto, Franco; Martelli, Sabina; Piazzolla, Mario; Pugliese, Francesco; Venuta, Federico; De Giacomo, Tiziano title: BEDSIDE TRANSCERVICAL-TRANSTRACHEAL POST-INTUBATION INJURY REPAIR IN A COVID-19 PATIENT date: 2020-04-22 journal: Ann Thorac Surg DOI: 10.1016/j.athoracsur.2020.04.009 sha: doc_id: 263214 cord_uid: h6lkvlj3 file: cache/cord-263064-n4c0m5hn.json key: cord-263064-n4c0m5hn authors: Choudhury, Ivana; Han, Haowei; Manthani, Kaushik; Gandhi, Sandeep; Dabhi, Rameshchandra title: COVID-19 as a Possible Cause of Functional Exhaustion of CD4 and CD8 T-cells and Persistent Cause of Methicillin-Sensitive Staphylococcus aureus Bacteremia date: 2020-07-04 journal: Cureus DOI: 10.7759/cureus.9000 sha: doc_id: 263064 cord_uid: n4c0m5hn file: cache/cord-263716-ywsm11aw.json key: cord-263716-ywsm11aw authors: Zhou, Yifan; Li, Wei; Wang, David; Mao, Ling; Jin, Huijuan; Li, Yanan; Hong, Candong; Chen, Shengcai; Chang, Jiang; He, Quanwei; Wang, Mengdie; Hu, Bo title: Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management date: 2020-05-04 journal: Stroke Vasc Neurol DOI: 10.1136/svn-2020-000398 sha: doc_id: 263716 cord_uid: ywsm11aw file: cache/cord-262878-ygvbqmxd.json key: cord-262878-ygvbqmxd authors: de Carranza, María; Salazar, Danilo-Eduardo; Troya, Jesús; Alcázar, Roberto; Peña, Cristina; Aragón, Esther; Domínguez, Marta; Torres, Juan; Muñoz-Rivas, Nuria title: Aortic thrombus in patients with severe COVID-19: review of three cases date: 2020-07-09 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02219-z sha: doc_id: 262878 cord_uid: ygvbqmxd file: cache/cord-263046-3aerbonz.json key: cord-263046-3aerbonz authors: Hadfield, James N.; Gray, Andrew C. title: The Evolving COVID-19 Effect on Hip Fracture Patients date: 2020-06-15 journal: Injury DOI: 10.1016/j.injury.2020.06.006 sha: doc_id: 263046 cord_uid: 3aerbonz file: cache/cord-263031-cco2vh0f.json key: cord-263031-cco2vh0f authors: Vultaggio, Alessandra; Agache, Ioana; Akdis, Cezmi A.; Akdis, Mubeccel; Bavbek, Sevim; Bossios, Apostolos; Bousquet, Jean; Boyman, Onur; Chaker, Adam M.; Chan, Susan; Chatzipetrou, Alexia; Feleszko, Wojciech; Firinu, Davide; Jutel, Marek; Kauppi, Paula; Klimek, Ludger; Kolios, Antonios; Kothari, Akash; Kowalski, Marek L.; Matucci, Andrea; Palomares, Oscar; Pfaar, Oliver; Rogala, Barbara; Untersmayr, Eva; Eiwegger, Thomas title: Considerations on Biologicals for Patients with allergic disease in times of the COVID‐19 pandemic: an EAACI Statement date: 2020-06-05 journal: Allergy DOI: 10.1111/all.14407 sha: doc_id: 263031 cord_uid: cco2vh0f file: cache/cord-263191-osa3ylkl.json key: cord-263191-osa3ylkl authors: Pericàs, Juan M.; Cucchiari, David; Torrallardona-Murphy, Orla; Calvo, Júlia; Serralabós, Júlia; Alvés, Elisenda; Agelet, Aleix; Hidalgo, Judit; Alves, Eduarda; Castells, Eva; Seijas, Nuria; Hernández, Carme; Bodro, Marta; Cardozo, Celia; Coloma, Emmanuel; Nicolás, David title: Hospital at home for the management of COVID-19: preliminary experience with 63 patients date: 2020-09-29 journal: Infection DOI: 10.1007/s15010-020-01527-z sha: doc_id: 263191 cord_uid: osa3ylkl file: cache/cord-263599-cqol8zf2.json key: cord-263599-cqol8zf2 authors: Goodman, Larry; Segreti, John title: Infectious diarrhea date: 1999-07-31 journal: Disease-a-Month DOI: 10.1016/s0011-5029(99)90000-7 sha: doc_id: 263599 cord_uid: cqol8zf2 file: cache/cord-263691-ovsi38bx.json key: cord-263691-ovsi38bx authors: Sadler, Diego; Chaulagain, Chakra; Alvarado, Beatrice; Cubeddu, Robert; Stone, Elizabeth; Samuel, Thomas; Bastos, Bruno; Grossman, David; Fu, Chieh-Lin; Alley, Evan; Nagarajan, Arun; Nguyen, Timmy; Ahmed, Wesam; Elson, Leah; Nahleh, Zeina title: Practical and cost-effective model to build and sustain a cardio-oncology program date: 2020-07-16 journal: Cardiooncology DOI: 10.1186/s40959-020-00063-x sha: doc_id: 263691 cord_uid: ovsi38bx file: cache/cord-263530-t9ryky6f.json key: cord-263530-t9ryky6f authors: Kamal, Yasmine Mohamed; Abdelmajid, Yasmin; Al Madani, Abubaker Abdul Rahman title: Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully date: 2020-09-16 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-237378 sha: doc_id: 263530 cord_uid: t9ryky6f file: cache/cord-263883-7ba0huwy.json key: cord-263883-7ba0huwy authors: Ansarin, Khalil; Tolouian, Ramin; Ardalan, Mohammadreza; Taghizadieh, Ali; Varshochi, Mojtaba; Teimouri, Soheil; Vaezi, Tahere; Valizadeh, Hamed; Saleh, Parviz; Safiri, Saeid; Chapman, Kenneth R. title: Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial date: 2020-07-19 journal: Bioimpacts DOI: 10.34172/bi.2020.27 sha: doc_id: 263883 cord_uid: 7ba0huwy file: cache/cord-263241-qzerj9bs.json key: cord-263241-qzerj9bs authors: Liu, Liu; He, Fan; Cai, Si-Si; Hu, Kai-Li; Yu, Chong; Huang, Yi; Zeng, Rui; Xu, Gang title: Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction date: 2020-08-20 journal: Chin Med J (Engl) DOI: 10.1097/cm9.0000000000000945 sha: doc_id: 263241 cord_uid: qzerj9bs file: cache/cord-264327-uzlavmhx.json key: cord-264327-uzlavmhx authors: Singh, Rajat; Domenico, Christopher; Rao, Sriram; Urgo, Kimberly; Prenner, Stuart; Wald, Joyce; Atluri, Pavan; Birati, Edo Y. title: Novel Coronavirus Disease 2019 in a Patient on Durable Left Ventricular Assist Device Support date: 2020-04-17 journal: J Card Fail DOI: 10.1016/j.cardfail.2020.04.007 sha: doc_id: 264327 cord_uid: uzlavmhx file: cache/cord-263066-umvojci8.json key: cord-263066-umvojci8 authors: Smondack, P.; Gravier, F.-É.; Prieur, G.; Repel, A.; Muir, J.-F.; Cuvelier, A.; Combret, Y.; Medrinal, C.; Bonnevie, T. title: Kinésithérapie et COVID-19 : de la réanimation à la réhabilitation à domicile. Synthèse des recommandations internationales date: 2020-10-13 journal: Rev Mal Respir DOI: 10.1016/j.rmr.2020.09.001 sha: doc_id: 263066 cord_uid: umvojci8 file: cache/cord-263882-s5oxr6es.json key: cord-263882-s5oxr6es authors: Najar Nobar, Niloufar; Goodarzi, Azadeh title: Patients with specific skin disorders who are affected by COVID‐19: what do experiences say about management strategies? : A systematic review date: 2020-06-18 journal: Dermatol Ther DOI: 10.1111/dth.13867 sha: doc_id: 263882 cord_uid: s5oxr6es file: cache/cord-263793-bmadusm6.json key: cord-263793-bmadusm6 authors: Velissaris, Dimitrios; Dimopoulos, George; Parissis, John; Alexiou, Zoi; Antonakos, Nikolaos; Babalis, Dimitrios; Gerakari, Styliani; Kaldis, Vassileios; Koutoukas, Pantelis; Lada, Malvina; Leventogiannis, Konstantinos; Pantazopoulos, Ioannis; Papadopoulos, Antonios; Polyzogopoulou, Eftihia; Gogos, Charalambos; Armaganidis, Apostolos; Giamarellos-Bourboulis, Evangelos J. title: Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group date: 2020-05-12 journal: Infect Dis Ther DOI: 10.1007/s40121-020-00301-w sha: doc_id: 263793 cord_uid: bmadusm6 file: cache/cord-264073-yhztrscf.json key: cord-264073-yhztrscf authors: Betonico, Gustavo Navarro; Lima, Emerson Quintino; Tome, Ana Carolina Nakamura title: Challenges in COVID‐19 medical response: a nephrology perspective date: 2020-06-20 journal: Eur J Clin Invest DOI: 10.1111/eci.13328 sha: doc_id: 264073 cord_uid: yhztrscf file: cache/cord-264180-0vd3tr9j.json key: cord-264180-0vd3tr9j authors: Gupta, Anupam K; Jackson, Max; Genuit, Thomas; Roberts, John title: Is It Safe to Perform Lung Surgery During the Coronavirus Pandemic? date: 2020-08-14 journal: Cureus DOI: 10.7759/cureus.9749 sha: doc_id: 264180 cord_uid: 0vd3tr9j file: cache/cord-263908-4ti8l2ea.json key: cord-263908-4ti8l2ea authors: Gupta, Ritesh; Hussain, Akhtar; Misra, Anoop title: Diabetes and COVID-19: evidence, current status and unanswered research questions date: 2020-05-13 journal: Eur J Clin Nutr DOI: 10.1038/s41430-020-0652-1 sha: doc_id: 263908 cord_uid: 4ti8l2ea file: cache/cord-264122-n64tm6qr.json key: cord-264122-n64tm6qr authors: Gaballa, Salem; AlJaf, Avan; Patel, Kashyap; Lindsay, Jane; Hlaing, Kyaw M title: COVID-19 Fears May Be Worse Than the Virus: A Case of Cardiogenic Shock Secondary to Post-Myocardial Infarction Ventricular Septum Rupture date: 2020-06-24 journal: Cureus DOI: 10.7759/cureus.8809 sha: doc_id: 264122 cord_uid: n64tm6qr file: cache/cord-264295-7ojvhwb0.json key: cord-264295-7ojvhwb0 authors: Maddaloni, Ernesto; D’Onofrio, Luca; Alessandri, Francesco; Mignogna, Carmen; Leto, Gaetano; Pascarella, Giuseppe; Mezzaroma, Ivano; Lichtner, Miriam; Pozzilli, Paolo; Agrò, Felice Eugenio; Rocco, Monica; Pugliese, Francesco; Lenzi, Andrea; Holman, Rury R.; Mastroianni, Claudio Maria; Buzzetti, Raffaella title: Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II) date: 2020-10-01 journal: Cardiovasc Diabetol DOI: 10.1186/s12933-020-01140-2 sha: doc_id: 264295 cord_uid: 7ojvhwb0 file: cache/cord-264368-p2fwuh0i.json key: cord-264368-p2fwuh0i authors: Gozgec, Elif; Ogul, Hayri; Alay, Handan title: Left Ventricular Thrombus in a Patient Infecting by Covid-19 date: 2020-07-28 journal: Ann Thorac Surg DOI: 10.1016/j.athoracsur.2020.07.008 sha: doc_id: 264368 cord_uid: p2fwuh0i file: cache/cord-264449-p3tgjuj4.json key: cord-264449-p3tgjuj4 authors: Majumdar, PK; Gupta, RK title: Orthopaedic Surgery in Times of COVID-19 in India date: 2020-07-17 journal: Malays Orthop J DOI: 10.5704/moj.2007.005 sha: doc_id: 264449 cord_uid: p3tgjuj4 file: cache/cord-264647-9r443j3l.json key: cord-264647-9r443j3l authors: Talamonti, G.; Colistra, Davide; Crisà, Francesco; Cenzato, Marco; Giorgi, Pietro; D’Aliberti, Giuseppe title: Spinal epidural abscess in COVID-19 patients date: 2020-09-10 journal: J Neurol DOI: 10.1007/s00415-020-10211-z sha: doc_id: 264647 cord_uid: 9r443j3l file: cache/cord-264673-67zopf7s.json key: cord-264673-67zopf7s authors: Shi, Hongbo; Wang, Wenjing; Yin, Jiming; Ouyang, Yabo; Pang, Lijun; Feng, Yingmei; Qiao, Luxin; Guo, Xianghua; Shi, Honglin; Jin, Ronghua; Chen, Dexi title: The inhibition of IL-2/IL-2R gives rise to CD8(+) T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia date: 2020-06-08 journal: Cell Death Dis DOI: 10.1038/s41419-020-2636-4 sha: doc_id: 264673 cord_uid: 67zopf7s file: cache/cord-264751-2l3cqhe2.json key: cord-264751-2l3cqhe2 authors: Gawie-Rotman, Moran; Hazan, Guy; Fruchtman, Yariv; Cavari, Yuval; Ling, Eduard; Lazar, Isaac; Leibovitz, Eugene title: Purpuric rash and fever among hospitalized children aged 0–18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology date: 2019-02-22 journal: Pediatr Neonatol DOI: 10.1016/j.pedneo.2019.02.002 sha: doc_id: 264751 cord_uid: 2l3cqhe2 file: cache/cord-262766-ndn6iwre.json key: cord-262766-ndn6iwre authors: Easom, Nicholas; Moss, Peter; Barlow, Gavin; Samson, Anda; Taynton, Tom; Adams, Kate; Ivan, Monica; Burns, Phillipa; Gajee, Kavitha; Eastick, Kirstine; Lillie, Patrick title: 68 Consecutive patients assessed for COVID-19 infection; experience from a UK regional infectious disease unit date: 2020-03-06 journal: nan DOI: 10.1101/2020.02.29.20029462 sha: doc_id: 262766 cord_uid: ndn6iwre file: cache/cord-263628-ac9gld5l.json key: cord-263628-ac9gld5l authors: Sivapalan, Pradeesh; Ulrik, Charlotte Suppli; Lappere, Therese Sophie; Eklöf, Josefin Viktoria; Shaker, Saher Burhan; Bødtger, Uffe Christian Steinholtz; Browatzki, Andrea; Meyer, Christian Niels; Weinreich, Ulla Møller; Laursen, Christian B.; Biering-Sørensen, Tor; Knop, Filip Krag; Lundgren, Jens D.; Jensen, Jens-Ulrik Stæhr title: Proactive prophylaxis with azithromycin and hydroxychloroquine in hospitalized patients with COVID-19 (ProPAC-COVID): a statistical analysis plan date: 2020-10-20 journal: Trials DOI: 10.1186/s13063-020-04795-0 sha: doc_id: 263628 cord_uid: ac9gld5l file: cache/cord-264504-nnvof29x.json key: cord-264504-nnvof29x authors: Malentacchi, Maria; Gned, Dario; Angelino, Valeria; Demichelis, Sara; Perboni, Alberto; Veltri, Andrea; Bertolotto, Antonio; Capobianco, Marco title: Concomitant brain arterial and venous thrombosis in a COVID‐19 patient date: 2020-06-05 journal: Eur J Neurol DOI: 10.1111/ene.14380 sha: doc_id: 264504 cord_uid: nnvof29x file: cache/cord-264042-4hc2i25r.json key: cord-264042-4hc2i25r authors: Chim, Harvey; Kian, Hing Soo; Low, Edwin; Chan, Gregory title: Severe Acute Respiratory Syndrome in a Naval Diver date: 2006-06-17 journal: Mil Med DOI: 10.7205/milmed.171.6.491 sha: doc_id: 264042 cord_uid: 4hc2i25r file: cache/cord-264889-1vsvcza2.json key: cord-264889-1vsvcza2 authors: Jackson, Craig T.; Checchia, Paul A. title: The Ties That Bind: A Coronavirus Disease Journey date: 2020-10-16 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000250 sha: doc_id: 264889 cord_uid: 1vsvcza2 file: cache/cord-263294-9r84f19u.json key: cord-263294-9r84f19u authors: Chen, Siyu; Liao, E.; Cao, Dongmei; Gao, Ying; Sun, Guoqiang; Shao, Yong title: Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia date: 2020-04-10 journal: J Med Virol DOI: 10.1002/jmv.25789 sha: doc_id: 263294 cord_uid: 9r84f19u file: cache/cord-264829-ynel6ore.json key: cord-264829-ynel6ore authors: Momtazmanesh, Sara; Shobeiri, Parnian; Hanaei, Sara; Mahmoud-Elsayed, Hani; Dalvi, Bharat; Malakan Rad, Elaheh title: Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool date: 2020-07-13 journal: Egypt Heart J DOI: 10.1186/s43044-020-00075-z sha: doc_id: 264829 cord_uid: ynel6ore file: cache/cord-264543-b4zwinh2.json key: cord-264543-b4zwinh2 authors: Daher, Valéria Barcelos; Soares Oliveira, Daniela Silva; Daher Júnior, Mauro Freitas; Júnior de Melo Fernandes, Edson; de Castro Guimarães, Valeriana; Bomtempo de Castro, João Victor; Moya, Marcela Ibanhes title: Anosmia: A marker of infection by the new corona virus date: 2020-06-12 journal: Respir Med Case Rep DOI: 10.1016/j.rmcr.2020.101129 sha: doc_id: 264543 cord_uid: b4zwinh2 file: cache/cord-264779-71s7e18i.json key: cord-264779-71s7e18i authors: Neumann, Natalie R.; Chai, Peter R.; Wood, David M.; Greller, Howard A.; Mycyk, Mark B. title: Medical Toxicology and COVID-19: Our Role in a Pandemic date: 2020-04-30 journal: J Med Toxicol DOI: 10.1007/s13181-020-00778-4 sha: doc_id: 264779 cord_uid: 71s7e18i file: cache/cord-264843-cwtdkylo.json key: cord-264843-cwtdkylo authors: Chen, Justin A.; Chung, Wei-Jean; Young, Sarah K.; Tuttle, Margaret C.; Collins, Michelle B.; Darghouth, Sarah L.; Longley, Regina; Levy, Raymond; Razafsha, Mahdi; Kerner, Jeffrey C.; Wozniak, Janet; Huffman, Jeff C. title: COVID-19 and telepsychiatry: Early outpatient experiences and implications for the future date: 2020-07-09 journal: Gen Hosp Psychiatry DOI: 10.1016/j.genhosppsych.2020.07.002 sha: doc_id: 264843 cord_uid: cwtdkylo file: cache/cord-265052-hfuvm1oh.json key: cord-265052-hfuvm1oh authors: Turan, Çağrı; Metin, Nurcan; Utlu, Zeynep; Öner, Ümran; Kotan, Özgür Sadık title: Change of the diagnostic distribution in applicants to dermatology after COVID ‐19 pandemic: What it whispers to us? date: 2020-06-12 journal: Dermatol Ther DOI: 10.1111/dth.13804 sha: doc_id: 265052 cord_uid: hfuvm1oh file: cache/cord-265799-qda5awuc.json key: cord-265799-qda5awuc authors: Carothers, Chancey; Birrer, Kara; Vo, Mai title: Acetylcysteine for the Treatment of Suspected Remdesivir‐Associated Acute Liver Failure in COVID‐19: A Case Series date: 2020-10-02 journal: Pharmacotherapy DOI: 10.1002/phar.2464 sha: doc_id: 265799 cord_uid: qda5awuc file: cache/cord-264972-hrbo3awj.json key: cord-264972-hrbo3awj authors: Yee, Colin; Suarthana, Eva; Dendukuri, Nandini; Nicolau, Ioana; Semret, Makeda; Frenette, Charles title: Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting date: 2016-11-01 journal: Am J Infect Control DOI: 10.1016/j.ajic.2016.04.221 sha: doc_id: 264972 cord_uid: hrbo3awj file: cache/cord-265053-x70501t3.json key: cord-265053-x70501t3 authors: Pourhomayoun, Mohammad; Shakibi, Mahdi title: Predicting Mortality Risk in Patients with COVID-19 Using Artificial Intelligence to Help Medical Decision-Making date: 2020-04-01 journal: nan DOI: 10.1101/2020.03.30.20047308 sha: doc_id: 265053 cord_uid: x70501t3 file: cache/cord-265082-gjbabh4g.json key: cord-265082-gjbabh4g authors: Xuan, Tian-ming; Wang, Xing-xiang; Pu, Xiang-yuan; Han, Wei-li; Guo, Xiao-gang title: Primary percutaneous coronary intervention in a COVID-19 patient with ST-segment elevation myocardial infarction after lung transplantation: a case report date: 2020-05-09 journal: J Zhejiang Univ Sci B DOI: 10.1631/jzus.b2000182 sha: doc_id: 265082 cord_uid: gjbabh4g file: cache/cord-265721-wmz3wywi.json key: cord-265721-wmz3wywi authors: Saini, Kamal S.; Lanza, Carlo; Romano, Marco; de Azambuja, Evandro; Cortes, Javier; de las Heras, Begoña; de Castro, Javier; Lamba Saini, Monika; Loibl, Sibylle; Curigliano, Giuseppe; Twelves, Chris; Leone, Manuela; Patnaik, Mrinal M. title: Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy date: 2020-06-22 journal: Br J Cancer DOI: 10.1038/s41416-020-0948-x sha: doc_id: 265721 cord_uid: wmz3wywi file: cache/cord-264924-ds6jv5ek.json key: cord-264924-ds6jv5ek authors: Tambyah, Paul A title: Severe acute respiratory syndrome from the trenches, at a Singapore university hospital date: 2004-11-30 journal: The Lancet Infectious Diseases DOI: 10.1016/s1473-3099(04)01175-2 sha: doc_id: 264924 cord_uid: ds6jv5ek file: cache/cord-265111-d44ireu5.json key: cord-265111-d44ireu5 authors: D’Ardes, Damiano; Pontolillo, Michela; Esposito, Lucia; Masciarelli, Mara; Boccatonda, Andrea; Rossi, Ilaria; Bucci, Marco; Guagnano, Maria Teresa; Ucciferri, Claudio; Santilli, Francesca; Di Nicola, Marta; Falasca, Katia; Vecchiet, Jacopo; Schael, Thomas; Cipollone, Francesco title: Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids date: 2020-08-31 journal: Microorganisms DOI: 10.3390/microorganisms8091327 sha: doc_id: 265111 cord_uid: d44ireu5 file: cache/cord-264952-0t0t4x0y.json key: cord-264952-0t0t4x0y authors: Smith, Sean R; Jenq, Grace; Claflin, Ted; Magnant, Chris; Haig, Andrew J; Hurvitz, Edward title: Proposed Workflow for Rehabilitation in a Field Hospital Setting During the COVID‐19 Pandemic date: 2020-05-15 journal: PM R DOI: 10.1002/pmrj.12405 sha: doc_id: 264952 cord_uid: 0t0t4x0y file: cache/cord-265278-wf5pbvvt.json key: cord-265278-wf5pbvvt authors: Fishman, Jay A.; Roberts, Matthew B.; Zhang, Eric W.; Kumar, Deepali; Hirsch, Hans H.; Maggiore, Umberto title: Case 29-2020: A 66-Year-Old Man with Fever and Shortness of Breath after Liver Transplantation date: 2020-09-17 journal: N Engl J Med DOI: 10.1056/nejmcpc2004982 sha: doc_id: 265278 cord_uid: wf5pbvvt file: cache/cord-265098-u5qssib9.json key: cord-265098-u5qssib9 authors: Fu, Xin-yan; Shen, Xiang-feng; Cheng, Yong-ran; Zhou, Meng-Yun; Ye, Lan; Feng, Zhan-hui; Xu, Zhao; Chen, Juan; Wang, Ming-Wei; Zhang, Xing-wei title: Effect of COVID-19 outbreak on the treatment time of patients with acute ST-segment elevation myocardial infarction date: 2020-09-17 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.09.038 sha: doc_id: 265098 cord_uid: u5qssib9 file: cache/cord-264610-kxebc12r.json key: cord-264610-kxebc12r authors: Chen, Yu; Dong, Yuanji; Cai, Shaozhe; Ye, Cong; Dong, Lingli title: Clinical characteristics of IgG4-RD patients infected with COVID-19 in Hubei, China date: 2020-05-16 journal: Semin Arthritis Rheum DOI: 10.1016/j.semarthrit.2020.04.015 sha: doc_id: 264610 cord_uid: kxebc12r file: cache/cord-265818-wme1360n.json key: cord-265818-wme1360n authors: Cooley, Laura title: Trust and Communication: Responding to Uncertainty date: 2020-07-15 journal: J Patient Exp DOI: 10.1177/2374373520938476 sha: doc_id: 265818 cord_uid: wme1360n file: cache/cord-265022-p5cab562.json key: cord-265022-p5cab562 authors: Kotfis, Katarzyna; Williams Roberson, Shawniqua; Wilson, Jo Ellen; Dabrowski, Wojciech; Pun, Brenda T.; Ely, E. Wesley title: COVID-19: ICU delirium management during SARS-CoV-2 pandemic date: 2020-04-28 journal: Crit Care DOI: 10.1186/s13054-020-02882-x sha: doc_id: 265022 cord_uid: p5cab562 file: cache/cord-265230-ozyx8u64.json key: cord-265230-ozyx8u64 authors: Takahari, Daisuke; Shinozaki, Eiji; Wakatsuki, Takeru; Ooki, Akira; Ozaka, Masato; Suzuki, Takeshi; Nakayama, Izuma; Osumi, Hiroki; Kamiimabeppu, Daisaku; Sato, Taro; Ogura, Mariko; Suenaga, Mitsukuni; Chin, Keisho; Yamaguchi, Kensei title: Managing a gastrointestinal oncology practice in Japan during the COVID-19 pandemic: single institutional experience in The Cancer Institute Hospital of Japanese Foundation for Cancer Research date: 2020-10-21 journal: Int J Clin Oncol DOI: 10.1007/s10147-020-01806-7 sha: doc_id: 265230 cord_uid: ozyx8u64 file: cache/cord-265812-1hcp36cw.json key: cord-265812-1hcp36cw authors: De Jong, Cornelis N.; Saes, Lotte; Klerk, Clara P. W.; Van der Klift, Marjolein; Cornelissen, Jan J.; Broers, Annoek E. C. title: Etanercept for steroid-refractory acute graft-versus-host disease: A single center experience date: 2017-10-26 journal: PLoS One DOI: 10.1371/journal.pone.0187184 sha: doc_id: 265812 cord_uid: 1hcp36cw file: cache/cord-265967-y4639p9m.json key: cord-265967-y4639p9m authors: Rottenberg, Yakir; Goldzweig, Gil; Baider, Lea title: Geriatric patient-centered care during the COVID-19: Provision of interactions vs. the imposition of isolation date: 2020-06-18 journal: J Geriatr Oncol DOI: 10.1016/j.jgo.2020.06.016 sha: doc_id: 265967 cord_uid: y4639p9m file: cache/cord-266010-ectnfv5z.json key: cord-266010-ectnfv5z authors: Pediconi, Federica; Galati, Francesca; Bernardi, Daniela; Belli, Paolo; Brancato, Beniamino; Calabrese, Massimo; Camera, Lucia; Carbonaro, Luca A.; Caumo, Francesca; Clauser, Paola; Girardi, Veronica; Iacconi, Chiara; Martincich, Laura; Panizza, Pietro; Petrillo, Antonella; Schiaffino, Simone; Tagliafico, Alberto; Trimboli, Rubina M.; Zuiani, Chiara; Sardanelli, Francesco; Montemezzi, Stefania title: Breast imaging and cancer diagnosis during the COVID-19 pandemic: recommendations from the Italian College of Breast Radiologists by SIRM date: 2020-07-13 journal: Radiol Med DOI: 10.1007/s11547-020-01254-3 sha: doc_id: 266010 cord_uid: ectnfv5z file: cache/cord-265934-wjdxqj8h.json key: cord-265934-wjdxqj8h authors: Singh, Amrita K.; Kasle, David A.; Jiang, Roy; Sukys, Jordan; Savoca, Emily L.; Z. Lerner, Michael; Kohli, Nikita title: A Review of Telemedicine Applications in Otorhinolaryngology: Considerations During the Coronavirus Disease of 2019 Pandemic date: 2020-10-01 journal: Laryngoscope DOI: 10.1002/lary.29131 sha: doc_id: 265934 cord_uid: wjdxqj8h file: cache/cord-266456-10tjzqep.json key: cord-266456-10tjzqep authors: Sadeghipour, Parham; Talasaz, Azita H.; Eslami, Vahid; Geraiely, Babak; Vojdanparast, Mohammad; Sedaghat, Mojtaba; Moosavi, Abouzar Fakhr; Alipour‐Parsa, Saeed; Aminian, Bahram; Firouzi, Ata; Ghaffari, Samad; Ghasemi, Massoud; Saleh, Davood Kazemi; Khosravi, Alireza; Kojuri, Javad; Noohi, Feridoun; Pourhosseini, Hamid; Salarifar, Mojtaba; Salehi, Mohamad Reza; Sezavar, Hashem; Shabestari, Mahmoud; Soleimani, Abbas; Tabarsi, Payam; Parsa, Amir Farhang Zand; Abdi, Seifollah title: Management of ST‐segment‐elevation myocardial infarction during the coronavirus disease 2019 (COVID‐19) outbreak: Iranian“247” National Committee's position paper on primary percutaneous coronary intervention date: 2020-04-22 journal: Catheter Cardiovasc Interv DOI: 10.1002/ccd.28889 sha: doc_id: 266456 cord_uid: 10tjzqep file: cache/cord-265848-afkeuwup.json key: cord-265848-afkeuwup authors: nan title: Chapter 2 Emergency Management of Poisoning date: 2007-12-31 journal: Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose DOI: 10.1016/b978-0-7216-0693-4.50007-4 sha: doc_id: 265848 cord_uid: afkeuwup file: cache/cord-265262-r01u4jr6.json key: cord-265262-r01u4jr6 authors: Cannarella, Rossella; Calogero, Aldo E.; Condorelli, Rosita A.; Aversa, Antonio; La Vignera, Sandro title: Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients date: 2020-10-13 journal: Ther Adv Endocrinol Metab DOI: 10.1177/2042018820966438 sha: doc_id: 265262 cord_uid: r01u4jr6 file: cache/cord-265472-b1s4stvz.json key: cord-265472-b1s4stvz authors: Guimarães, Luísa Eça; Baker, Britain; Perricone, Carlo; Shoenfeld, Yehuda title: Vaccines, adjuvants and autoimmunity date: 2015-10-31 journal: Pharmacological Research DOI: 10.1016/j.phrs.2015.08.003 sha: doc_id: 265472 cord_uid: b1s4stvz file: cache/cord-266294-ua22udlc.json key: cord-266294-ua22udlc authors: Koch, Oliver; Sheehy, Susanne; Sargent, Catherine; Democratis, Jane; Abbas, Sarah; Schiefermueller, Jurgen; Angus, Brian J. title: 29 Antiviral drugs date: 2010-12-31 journal: Side Effects of Drugs Annual DOI: 10.1016/s0378-6080(10)32029-0 sha: doc_id: 266294 cord_uid: ua22udlc file: cache/cord-266079-nv28ppft.json key: cord-266079-nv28ppft authors: Dai, Jinghong; Xiong, Yali; Li, Hui; Qian, Yajun; Xu, Ying; Xu, Qingqing; Yan, Xin; Tang, Jian title: Corticosteroid treatment in severe COVID-19 pneumonia: two cases and literature review date: 2020-05-25 journal: Clin Rheumatol DOI: 10.1007/s10067-020-05172-7 sha: doc_id: 266079 cord_uid: nv28ppft file: cache/cord-266255-898h9rl1.json key: cord-266255-898h9rl1 authors: nan title: Full Issue PDF date: 2020-08-31 journal: JACC: Cardiovascular Imaging DOI: 10.1016/s1936-878x(20)30581-7 sha: doc_id: 266255 cord_uid: 898h9rl1 file: cache/cord-266469-n484zqq1.json key: cord-266469-n484zqq1 authors: King, Michael J.; Lewis, Sara; El Homsi, Maria; Hernandez Meza, Gabriela; Bernheim, Adam; Jacobi, Adam; Chung, Michael; Taouli, Bachir title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system date: 2020-07-04 journal: Eur Radiol DOI: 10.1007/s00330-020-07040-z sha: doc_id: 266469 cord_uid: n484zqq1 file: cache/cord-266214-l8pmhcd5.json key: cord-266214-l8pmhcd5 authors: Wang, Xiaogang; Zhou, Yangzhao; Zhang, Xia; Li, Jianming; Zhou, Xinmin; Zhang, ZhiWei title: Management Strategies for Patients After CABG Surgery in the Outbreak of the COVID-19 Pandemic date: 2020-09-21 journal: Risk Manag Healthc Policy DOI: 10.2147/rmhp.s271133 sha: doc_id: 266214 cord_uid: l8pmhcd5 file: cache/cord-266583-avhiqlgy.json key: cord-266583-avhiqlgy authors: Kim, Hae Jin; Park, So Young; Lee, Ho Yun; Lee, Kyung Soo; Shin, Kyung Eun; Moon, Jung Won title: Ultra-Low-Dose Chest CT in Patients with Neutropenic Fever and Hematologic Malignancy: Image Quality and Its Diagnostic Performance date: 2014-07-18 journal: Cancer Res Treat DOI: 10.4143/crt.2013.132 sha: doc_id: 266583 cord_uid: avhiqlgy file: cache/cord-266429-0xaz8kbs.json key: cord-266429-0xaz8kbs authors: Bader, Feras; Manla, Yosef; Atallah, Bassam; Starling, Randall C title: Heart failure and COVID-19 date: 2020-07-27 journal: Heart Fail Rev DOI: 10.1007/s10741-020-10008-2 sha: doc_id: 266429 cord_uid: 0xaz8kbs file: cache/cord-266463-ci0g1dno.json key: cord-266463-ci0g1dno authors: Lopes, Renato D.; Macedo, Ariane Vieira Scarlatelli; de Barros e Silva, Pedro Gabriel Melo; Moll-Bernardes, Renata Junqueira; Feldman, Andre; D'Andréa Saba Arruda, Guilherme; de Souza, Andrea Silvestre; de Albuquerque, Denilson Campos; Mazza, Lilian; Santos, Mayara Fraga; Salvador, Natalia Zerbinatti; Gibson, C. Michael; Granger, Christopher B.; Alexander, John H.; de Souza, Olga Ferreira title: Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-05-13 journal: Am Heart J DOI: 10.1016/j.ahj.2020.05.002 sha: doc_id: 266463 cord_uid: ci0g1dno file: cache/cord-266722-qfn2dc1q.json key: cord-266722-qfn2dc1q authors: Wormser, Gary P.; Nunez, Miguel; Horn, David title: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date: 1987-06-30 journal: Clinics in Dermatology DOI: 10.1016/0738-081x(87)90013-7 sha: doc_id: 266722 cord_uid: qfn2dc1q file: cache/cord-266775-4npowkkz.json key: cord-266775-4npowkkz authors: Xu, Jun; Zhong, Shuqing; Liu, Jinghua; Li, Li; Li, Yong; Wu, Xinwei; Li, Zhijie; Deng, Peng; Zhang, Jingqiang; Zhong, Nanshan; Ding, Yanqing; Jiang, Yong title: Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis date: 2005-10-15 journal: Clin Infect Dis DOI: 10.1086/444461 sha: doc_id: 266775 cord_uid: 4npowkkz file: cache/cord-266160-464v4g8o.json key: cord-266160-464v4g8o authors: Bajaj, Jasmohan S; Garcia-Tsao, Guadalupe; Biggins, Scott; Kamath, Patrick S; Wong, Florence; McGeorge, Sara; Shaw, Jawaid; Pearson, Meredith; Chew, Micheal; Fagan, Andrew; de la Rosa Rodriguez, Randolph; Worthington, Janelle; Olofson, Amy; Weir, Vanessa; Trisolini, Calvin; Dwyer, Sarah; Reddy, K Rajender title: Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort date: 2020-07-13 journal: Gut DOI: 10.1136/gutjnl-2020-322118 sha: doc_id: 266160 cord_uid: 464v4g8o file: cache/cord-266450-g9vihgbk.json key: cord-266450-g9vihgbk authors: Tran, Michael; Sheth, Chirag; Bhandari, Rohan; Cameron, Scott J.; Hornacek, Deborah title: SARS-CoV-2 and pulmonary embolism: who stole the platelets? date: 2020-09-03 journal: Thromb J DOI: 10.1186/s12959-020-00229-8 sha: doc_id: 266450 cord_uid: g9vihgbk file: cache/cord-266455-rbblg4pu.json key: cord-266455-rbblg4pu authors: Poole, Stephen; Clark, Tristan W. title: Rapid syndromic molecular testing in pneumonia: The current landscape and future potential date: 2019-12-03 journal: J Infect DOI: 10.1016/j.jinf.2019.11.021 sha: doc_id: 266455 cord_uid: rbblg4pu file: cache/cord-266478-642m488a.json key: cord-266478-642m488a authors: Gino, Bruno; Wang, Zhujiang; d'Entremont, Philip; Renouf, Tia S; Dubrowski, Adam title: Automated Inflating Resuscitator (AIR): Design and Development of a 3D-Printed Ventilator Prototype and Corresponding Simulation Scenario Based on the Management of a Critical COVID-19 Patient date: 2020-07-11 journal: Cureus DOI: 10.7759/cureus.9134 sha: doc_id: 266478 cord_uid: 642m488a file: cache/cord-266730-mio282vy.json key: cord-266730-mio282vy authors: Li, Long‐quan; Huang, Tian; Wang, Yong‐qing; Wang, Zheng‐ping; Liang, Yuan; Huang, Tao‐bi; Zhang, Hui‐yun; Sun, Weiming; Wang, Yuping title: COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis date: 2020-03-23 journal: J Med Virol DOI: 10.1002/jmv.25757 sha: doc_id: 266730 cord_uid: mio282vy file: cache/cord-266750-41gth6o0.json key: cord-266750-41gth6o0 authors: Puzzitiello, Richard N.; Pagani, Nicholas R.; Moverman, Michael A.; Moon, Andrew S.; Menendez, Mariano E.; Ryan, Scott P. title: Inflammatory and Coagulative Considerations for the Management of Orthopaedic Trauma Patients With COVID-19: A Review of the Current Evidence and Our Surgical Experience date: 2020-05-14 journal: J Orthop Trauma DOI: 10.1097/bot.0000000000001842 sha: doc_id: 266750 cord_uid: 41gth6o0 file: cache/cord-266475-t04pukea.json key: cord-266475-t04pukea authors: Balestri, R.; Termine, S.; Rech, G.; Girardelli, C.R. title: Late onset of acral necrosis after SARS‐CoV‐2 infection resolution date: 2020-05-26 journal: J Eur Acad Dermatol Venereol DOI: 10.1111/jdv.16668 sha: doc_id: 266475 cord_uid: t04pukea file: cache/cord-266905-j9ljwqv0.json key: cord-266905-j9ljwqv0 authors: Ecker, Jeffrey L.; Minkoff, Howard L. title: Laboring Alone?: Brief Thoughts on Ethics and Practical Answers During the COVID-19 Pandemic date: 2020-05-15 journal: Am J Obstet Gynecol MFM DOI: 10.1016/j.ajogmf.2020.100141 sha: doc_id: 266905 cord_uid: j9ljwqv0 file: cache/cord-266744-31p212aq.json key: cord-266744-31p212aq authors: Dick, Lachlan; Green, James; Brown, Jasmine; Kennedy, Ewan; Cassidy, Richard; Othman, Salasiah; Berlansky, Martin title: Changes in Emergency General Surgery During Covid-19 in Scotland: A Prospective Cohort Study date: 2020-08-28 journal: World J Surg DOI: 10.1007/s00268-020-05760-3 sha: doc_id: 266744 cord_uid: 31p212aq file: cache/cord-267020-4mpc246u.json key: cord-267020-4mpc246u authors: Teixeira, Cassiano; Rosa, Regis Goulart; Rodrigues Filho, Edison Moraes; Fernandes, Eduardo de Oliveira title: The medical decision-making process in the time of the coronavirus pandemic date: 2020 journal: Rev Bras Ter Intensiva DOI: 10.5935/0103-507x.20200033 sha: doc_id: 267020 cord_uid: 4mpc246u file: cache/cord-266932-567lbktm.json key: cord-266932-567lbktm authors: Escalard, Simon; Chalumeau, Vanessa; Escalard, Clément; Redjem, Hocine; Delvoye, François; Hébert, Solène; Smajda, Stanislas; Ciccio, Gabriele; Desilles, Jean-Philippe; Mazighi, Mikael; Blanc, Raphael; Maïer, Benjamin; Piotin, Michel title: Early Brain Imaging Shows Increased Severity of Acute Ischemic Strokes With Large Vessel Occlusion in COVID-19 Patients date: 2020-08-19 journal: Stroke DOI: 10.1161/strokeaha.120.031011 sha: doc_id: 266932 cord_uid: 567lbktm file: cache/cord-266512-xh6zed03.json key: cord-266512-xh6zed03 authors: Scala, Enrico; Abeni, Damiano; Tedeschi, Alberto; Manzotti, Giuseppina; Yang, Baoran; Borrelli, Paolo; Marra, Alessandro; Giani, Mauro; Sgadari, Antonio; Saltalamacchia, Francesca; Asero, Riccardo title: Atopic statusprotects from severe complications of COVID‐19 date: 2020-08-16 journal: Allergy DOI: 10.1111/all.14551 sha: doc_id: 266512 cord_uid: xh6zed03 file: cache/cord-267124-8efdzlc0.json key: cord-267124-8efdzlc0 authors: Wichmann, Dominic; Sperhake, Jan-Peter; Lütgehetmann, Marc; Steurer, Stefan; Edler, Carolin; Heinemann, Axel; Heinrich, Fabian; Mushumba, Herbert; Kniep, Inga; Schröder, Ann Sophie; Burdelski, Christoph; de Heer, Geraldine; Nierhaus, Axel; Frings, Daniel; Pfefferle, Susanne; Becker, Heinrich; Bredereke-Wiedling, Hanns; de Weerth, Andreas; Paschen, Hans-Richard; Sheikhzadeh-Eggers, Sara; Stang, Axel; Schmiedel, Stefan; Bokemeyer, Carsten; Addo, Marylyn M.; Aepfelbacher, Martin; Püschel, Klaus; Kluge, Stefan title: Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study date: 2020-05-06 journal: Ann Intern Med DOI: 10.7326/m20-2003 sha: doc_id: 267124 cord_uid: 8efdzlc0 file: cache/cord-267142-ys7z7j8j.json key: cord-267142-ys7z7j8j authors: Cheema, Marvi; Aghazadeh, Helya; Nazarali, Samir; Ting, Andrew; Hodges, Jennifer; McFarlane, Alexandra; Kanji, Jamil N.; Zelyas, Nathan; Damji, Karim F.; Solarte, Carlos title: Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19) date: 2020-04-02 journal: Can J Ophthalmol DOI: 10.1016/j.jcjo.2020.03.003 sha: doc_id: 267142 cord_uid: ys7z7j8j file: cache/cord-267287-qodj254z.json key: cord-267287-qodj254z authors: Pintado, Juan F.; Gibaja, William; Vallejos, Rodrigo A.; Rosas, William; Guerra-Farfan, Ernesto; Nuñez, Jorge H. title: How COVID-19 has affected Emergent Visits to a Latin-American Trauma Department: Experience at a Peruvian National Trauma Referral Center date: 2020-11-03 journal: Injury DOI: 10.1016/j.injury.2020.11.005 sha: doc_id: 267287 cord_uid: qodj254z file: cache/cord-267357-7aap2cte.json key: cord-267357-7aap2cte authors: Elston, Dirk M. title: The coronavirus (COVID-19) epidemic and patient safety date: 2020-02-16 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.02.031 sha: doc_id: 267357 cord_uid: 7aap2cte file: cache/cord-267525-tg4uwent.json key: cord-267525-tg4uwent authors: Rezaei, Shawheen J.; Vogel, Andre C.; Gazdag, Brittany; Alakel, Nicholas; Kumar, Aditya Ravi; Mateen, Farrah J. title: Neuromyelitis optica practice and prescribing changes in the setting of Covid19: A survey of neurologists date: 2020-07-11 journal: J Neuroimmunol DOI: 10.1016/j.jneuroim.2020.577320 sha: doc_id: 267525 cord_uid: tg4uwent file: cache/cord-267621-oc8bw7ft.json key: cord-267621-oc8bw7ft authors: Kevorkian, Jean-Philippe; Riveline, Jean-Pierre; Vandiedonck, Claire; Girard, Diane; Galland, Joris; Féron, Florine; Gautier, Jean-François; Mégarbane, Bruno title: Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study date: 2020-09-01 journal: J Infect DOI: 10.1016/j.jinf.2020.08.045 sha: doc_id: 267621 cord_uid: oc8bw7ft file: cache/cord-267041-i94lyfsh.json key: cord-267041-i94lyfsh authors: Ellner, Jerrold J. title: Management of acute and chronic respiratory tract infections date: 1988-09-16 journal: The American Journal of Medicine DOI: 10.1016/0002-9343(88)90456-1 sha: doc_id: 267041 cord_uid: i94lyfsh file: cache/cord-268155-b8lqo52f.json key: cord-268155-b8lqo52f authors: Farrugia, Albert title: Plasma from donors convalescent from SARS-CoV-2 infection – A matter of priorities date: 2020-06-12 journal: Transfus Clin Biol DOI: 10.1016/j.tracli.2020.05.002 sha: doc_id: 268155 cord_uid: b8lqo52f file: cache/cord-268049-7xqln70d.json key: cord-268049-7xqln70d authors: Montrief, Tim; Ramzy, Mark; Long, Brit; Gottlieb, Michael; Hercz, Dan title: COVID-19 respiratory support in the emergency department setting date: 2020-08-08 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.08.001 sha: doc_id: 268049 cord_uid: 7xqln70d file: cache/cord-267300-zbipv9er.json key: cord-267300-zbipv9er authors: Alalwan, Adel A; Taher, Abdulraqeeb; Alaradi, Ali H title: A Hemodialysis Patient with Severe COVID-19 Pneumonia date: 2020-05-06 journal: Cureus DOI: 10.7759/cureus.7995 sha: doc_id: 267300 cord_uid: zbipv9er file: cache/cord-268168-yzvag38x.json key: cord-268168-yzvag38x authors: Scolnick, Barbara; Zupec-Kania, Beth; Calabrese, Lori; Aoki, Chiye; Hildebrandt, Thomas title: Remission from Chronic Anorexia Nervosa With Ketogenic Diet and Ketamine: Case Report date: 2020-07-30 journal: Front Psychiatry DOI: 10.3389/fpsyt.2020.00763 sha: doc_id: 268168 cord_uid: yzvag38x file: cache/cord-268140-s5lailkp.json key: cord-268140-s5lailkp authors: Atal, Shubham; Fatima, Zeenat title: IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? date: 2020-06-13 journal: Pharmaceut Med DOI: 10.1007/s40290-020-00342-z sha: doc_id: 268140 cord_uid: s5lailkp file: cache/cord-267132-nb0j6k3h.json key: cord-267132-nb0j6k3h authors: Loveday, H.P.; Wilson, J.A.; Pratt, R.J.; Golsorkhi, M.; Tingle, A.; Bak, A.; Browne, J.; Prieto, J.; Wilcox, M. title: epic3: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England date: 2013-12-10 journal: J Hosp Infect DOI: 10.1016/s0195-6701(13)60012-2 sha: doc_id: 267132 cord_uid: nb0j6k3h file: cache/cord-268347-xz6fptol.json key: cord-268347-xz6fptol authors: Kow, Chia Siang; Hasan, Syed Shahzad title: Pharmacotherapeutic considerations for systemic rheumatic diseases amid the COVID-19 pandemic: more questions than answers date: 2020-08-16 journal: Drugs Ther Perspect DOI: 10.1007/s40267-020-00767-1 sha: doc_id: 268347 cord_uid: xz6fptol file: cache/cord-267788-ukz2wz4a.json key: cord-267788-ukz2wz4a authors: Jaffe, Allan S; Cleland, John G F; Katus, Hugo A title: Myocardial injury in severe COVID-19 infection date: 2020-06-07 journal: Eur Heart J DOI: 10.1093/eurheartj/ehaa447 sha: doc_id: 267788 cord_uid: ukz2wz4a file: cache/cord-267947-dnv2xl0h.json key: cord-267947-dnv2xl0h authors: Gornet, Jean-Marc; Linh Tran Minh, My; Leleu, Florian; Hassid, Deborah title: What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19? date: 2020-04-24 journal: J Visc Surg DOI: 10.1016/j.jviscsurg.2020.04.017 sha: doc_id: 267947 cord_uid: dnv2xl0h file: cache/cord-267402-kca05rvz.json key: cord-267402-kca05rvz authors: South, Kieron; McCulloch, Laura; McColl, Barry W; Elkind, Mitchell SV; Allan, Stuart M; Smith, Craig J title: Preceding infection and risk of stroke: An old concept revived by the COVID-19 pandemic date: 2020-07-24 journal: Int J Stroke DOI: 10.1177/1747493020943815 sha: doc_id: 267402 cord_uid: kca05rvz file: cache/cord-268252-6g0vbd08.json key: cord-268252-6g0vbd08 authors: Richards, Wayne title: Being a dentist in the pandemic date: 2020-06-26 journal: Evid Based Dent DOI: 10.1038/s41432-020-0095-5 sha: doc_id: 268252 cord_uid: 6g0vbd08 file: cache/cord-268254-1mg7a17c.json key: cord-268254-1mg7a17c authors: Liu, Li; To, Kelvin Kai-Wang; Chan, Kwok-Hung; Wong, Yik-Chun; Zhou, Runhong; Kwan, Ka-Yi; Fong, Carol Ho-Yan; Chen, Lin-Lei; Choi, Charlotte Yee-Ki; Lu, Lu; Tsang, Owen Tak-Yin; Leung, Wai-Shing; To, Wing-Kin; Hung, Ivan Fan-Ngai; Yuen, Kwok-Yung; Chen, Zhiwei title: High neutralizing antibody titer in intensive care unit patients with COVID-19 date: 2020-07-20 journal: Emerging microbes & infections DOI: 10.1080/22221751.2020.1791738 sha: doc_id: 268254 cord_uid: 1mg7a17c file: cache/cord-268455-btuzihsy.json key: cord-268455-btuzihsy authors: de Santiago, Javier; Yelo, Carmen; F Chereguini, Maria; Conde, Ana; Galipienzo, Javier; Salvatierra, David; Linero, Manuel; Alonso, Sonsoles title: COVID-19: gynecologic cancer surgery at a single center in Madrid date: 2020-07-07 journal: Int J Gynecol Cancer DOI: 10.1136/ijgc-2020-001638 sha: doc_id: 268455 cord_uid: btuzihsy file: cache/cord-268211-egy8rgtl.json key: cord-268211-egy8rgtl authors: Barrasa, Helena; Rello, Jordi; Tejada, Sofia; Martín, Alejandro; Balziskueta, Goiatz; Vinuesa, Cristina; Fernández-Miret, Borja; Villagra, Ana; Vallejo, Ana; Sebastián, Ana San; Cabañes, Sara; Iribarren, Sebastián; Fonseca, Fernando; Maynar, Javier title: SARS-Cov-2 in Spanish Intensive Care: Early Experience with 15-day Survival In Vitoria date: 2020-04-09 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.04.001 sha: doc_id: 268211 cord_uid: egy8rgtl file: cache/cord-268632-p1rsz8fk.json key: cord-268632-p1rsz8fk authors: Tartari, Federico; Spadotto, Alberto; Zengarini, Corrado; Zanoni, Rossana; Guglielmo, Alba; Adorno, Alexander; Valzania, Cinzia; Pileri, Alessandro title: Herpes zoster in COVID‐19‐positive patients date: 2020-06-12 journal: Int J Dermatol DOI: 10.1111/ijd.15001 sha: doc_id: 268632 cord_uid: p1rsz8fk file: cache/cord-268324-86a0n0dc.json key: cord-268324-86a0n0dc authors: Charitos, Ioannis A; Ballini, Andrea; Bottalico, Lucrezia; Cantore, Stefania; Passarelli, Pier Carmine; Inchingolo, Francesco; D'Addona, Antonio; Santacroce, Luigi title: Special features of SARS-CoV-2 in daily practice date: 2020-09-26 journal: World J Clin Cases DOI: 10.12998/wjcc.v8.i18.3920 sha: doc_id: 268324 cord_uid: 86a0n0dc file: cache/cord-268531-igjeai8c.json key: cord-268531-igjeai8c authors: Zerah, Lorène; Baudouin, Édouard; Pépin, Marion; Mary, Morgane; Krypciak, Sébastien; Bianco, Céline; Roux, Swasti; Gross, Ariane; Toméo, Charlotte; Lemarié, Nadège; Dureau, Antoine; Bastiani, Sophie; Ketz, Flora; Boully, Clémence; de Villelongue, Cédric; Romdhani, Mouna; Desoutter, Marie-Astrid; Duron, Emmanuelle; David, Jean-Philippe; Thomas, Caroline; Paillaud, Elena; de Malglaive, Pauline; Bouvard, Eric; Lacrampe, Mathilde; Mercadier, Elise; Monti, Alexandra; Hanon, Olivier; Fossey-Diaz, Virginie; Bourdonnec, Lauriane; Riou, Bruno; Vallet, Hélène; Boddaert, Jacques title: Clinical Characteristics and Outcomes of 821 Older Patients With SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards: A Multicenter Retrospective Cohort Study date: 2020-08-26 journal: J Gerontol A Biol Sci Med Sci DOI: 10.1093/gerona/glaa210 sha: doc_id: 268531 cord_uid: igjeai8c file: cache/cord-268540-wrjzr3ws.json key: cord-268540-wrjzr3ws authors: Park, You Jeong; Farooq, Jeffrey; Cho, Justin; Sadanandan, Nadia; Cozene, Blaise; Gonzales-Portillo, Bella; Saft, Madeline; Borlongan, Maximillian C.; Borlongan, Mia C.; Shytle, R. Douglas; Willing, Alison E.; Garbuzova-Davis, Svitlana; Sanberg, Paul R.; Borlongan, Cesar V. title: Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics date: 2020-08-13 journal: Stem Cell Rev Rep DOI: 10.1007/s12015-020-10026-5 sha: doc_id: 268540 cord_uid: wrjzr3ws file: cache/cord-268561-vq1uhj5i.json key: cord-268561-vq1uhj5i authors: da Silva, Severino Jefferson Ribeiro; Silva, Caroline Targino Alves da; Guarines, Klarissa Miranda; Mendes, Renata Pessôa Germano; Pardee, Keith; Kohl, Alain; Pena, Lindomar title: Clinical and Laboratory Diagnosis of SARS-CoV-2, the Virus Causing COVID-19 date: 2020-08-04 journal: ACS Infect Dis DOI: 10.1021/acsinfecdis.0c00274 sha: doc_id: 268561 cord_uid: vq1uhj5i file: cache/cord-268879-ajd7ofc8.json key: cord-268879-ajd7ofc8 authors: Hui, David S.; Leung, Chi‐Chiu title: Contemporary Concise Review 2018: Respiratory infections and tuberculosis date: 2019-03-30 journal: Respirology DOI: 10.1111/resp.13542 sha: doc_id: 268879 cord_uid: ajd7ofc8 file: cache/cord-268886-mpceglk1.json key: cord-268886-mpceglk1 authors: Bourne, T.; Leonardi, M.; Kyriacou, C.; Al‐Memar, M.; Landolfo, C.; Cibula, D.; Condous, G.; Metzger, U.; Fischerova, D.; Timmerman, D.; van den Bosch, T. title: ISUOG Consensus Statement on rationalization of gynecological ultrasound services in context of SARS‐CoV‐2 date: 2020-04-08 journal: Ultrasound Obstet Gynecol DOI: 10.1002/uog.22047 sha: doc_id: 268886 cord_uid: mpceglk1 file: cache/cord-268326-sbz3uk5h.json key: cord-268326-sbz3uk5h authors: Bonam, Srinivasa Reddy; Wang, Fengjuan; Muller, Sylviane title: Lysosomes as a therapeutic target date: 2019-09-02 journal: Nat Rev Drug Discov DOI: 10.1038/s41573-019-0036-1 sha: doc_id: 268326 cord_uid: sbz3uk5h file: cache/cord-268617-1t7yaoct.json key: cord-268617-1t7yaoct authors: Ismaili, Nabil; Elmajjaoui, Sanaa title: COVID-19 and Gynecological Cancers: A Summary of International Recommendations date: 2020-08-31 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00475-x sha: doc_id: 268617 cord_uid: 1t7yaoct file: cache/cord-268952-3j43p9j3.json key: cord-268952-3j43p9j3 authors: Ueda Oshima, Masumi; Sandmaier, Brenda M.; Petersdorf, Effie; Flowers, Mary E.; Hill, Geoffrey R.; Lee, Stephanie J.; Appelbaum, Frederick R.; Carpenter, Paul A.; Baker, K. Scott; Connelly-Smith, Laura; McCool, Andrea; Elgar, Suni; Pergam, Steven A.; Liu, Catherine; Stewart, F. Marc; Mielcarek, Marco title: Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach date: 2020-09-26 journal: Bone Marrow Transplant DOI: 10.1038/s41409-020-01068-x sha: doc_id: 268952 cord_uid: 3j43p9j3 file: cache/cord-269051-nl0jfqxt.json key: cord-269051-nl0jfqxt authors: Patel, Krish; Gooley, Ted A.; Bailey, Neil; Bailey, Megumi; Hegerova, Livia; Batchelder, Ami; Holdread, Heather; Dunleavy, Vanessa; Downey, Tyler; Frisvold, Jens; Megrath, Samantha; Pagarigan, Krystle; Szeto, Jennie; Rueda, Justin; Islam, Adel; Maree, Cynthia; Nyatsatsang, Sonam; Bork, Sarah E.; Lipke, Anne; O’Mahony, D. Shane; Wagner, Teresa; Pulido, Juan; Mignone, John; Youssef, Samuel; Hartman, Matthew; Goldman, Jason D.; Pagel, John M. title: Use of the IL‐6R Antagonist Tocilizumab in Hospitalized COVID‐19 Patients date: 2020-08-03 journal: J Intern Med DOI: 10.1111/joim.13163 sha: doc_id: 269051 cord_uid: nl0jfqxt file: cache/cord-268843-zml9lbve.json key: cord-268843-zml9lbve authors: Cuvelier, Geoffrey D.E.; Rubin, Tamar S.; Junker, Anne; Sinha, Roona; Rosenberg, Alan M.; Wall, Donna A.; Schroeder, Marlis L. title: Clinical presentation, immunologic features, and hematopoietic stem cell transplant outcomes for IKBKB immune deficiency date: 2018-10-31 journal: Clin Immunol DOI: 10.1016/j.clim.2018.10.019 sha: doc_id: 268843 cord_uid: zml9lbve file: cache/cord-268939-ws74xprt.json key: cord-268939-ws74xprt authors: Ozoner, Baris; Gungor, Abuzer; Hasanov, Teyyup; Toktas, Zafer Orcun; Kilic, Turker title: Neurosurgery Practice During Coronavirus Disease 2019 (COVID-19) Pandemic date: 2020-05-28 journal: World Neurosurg DOI: 10.1016/j.wneu.2020.05.195 sha: doc_id: 268939 cord_uid: ws74xprt file: cache/cord-269087-f9hyntvf.json key: cord-269087-f9hyntvf authors: Li, X.; Qian, K.; Xie, L.-l.; Li, X.-j.; Cheng, M.; Jiang, L.; Schuller, B. W. title: A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19 date: 2020-04-04 journal: nan DOI: 10.1101/2020.03.30.20044545 sha: doc_id: 269087 cord_uid: f9hyntvf file: cache/cord-269031-sz8ieltb.json key: cord-269031-sz8ieltb authors: Solé, G; Salort-Campana, E; Pereon, Y; Stojkovic, T; Wahbi, K; Cintas, P; Adams, D; Laforet, P; Tiffreau, V; Desguerre, I; Pisella, LI; Molon, A; Attarian, S title: Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network date: 2020-04-20 journal: Rev Neurol (Paris) DOI: 10.1016/j.neurol.2020.04.004 sha: doc_id: 269031 cord_uid: sz8ieltb file: cache/cord-269009-0i2bvt77.json key: cord-269009-0i2bvt77 authors: D’Souza, Rohan; Malhamé, Isabelle; Teshler, Lizabeth; Acharya, Ganesh; Hunt, Beverley J.; McLintock, Claire title: A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID‐19 date: 2020-08-05 journal: Acta Obstet Gynecol Scand DOI: 10.1111/aogs.13962 sha: doc_id: 269009 cord_uid: 0i2bvt77 file: cache/cord-269099-q5nyzlhs.json key: cord-269099-q5nyzlhs authors: Lee, Jisun; Lee, Hyunsoo; McCuskey Shepley, Mardelle title: Exploring the spatial arrangement of patient rooms for minimum nurse travel in hospital nursing units in Korea date: 2020-07-23 journal: nan DOI: 10.1016/j.foar.2020.06.003 sha: doc_id: 269099 cord_uid: q5nyzlhs file: cache/cord-269280-1zbxjmxu.json key: cord-269280-1zbxjmxu authors: Shao, Connie title: The COVID trolley dilemma date: 2020-05-14 journal: Am J Surg DOI: 10.1016/j.amjsurg.2020.05.012 sha: doc_id: 269280 cord_uid: 1zbxjmxu file: cache/cord-269190-w74bjtq1.json key: cord-269190-w74bjtq1 authors: Lennox, Angela M. title: Care of the Geriatric Rabbit date: 2010-02-11 journal: Vet Clin North Am Exot Anim Pract DOI: 10.1016/j.cvex.2009.09.002 sha: doc_id: 269190 cord_uid: w74bjtq1 file: cache/cord-269205-g6eyvnou.json key: cord-269205-g6eyvnou authors: Nilsen, Marci Lee; Clump, David A.; Kubik, Mark; Losego, Karen; Mrozek, Alyssa; Pawlowicz, Elizabeth; Pickford, Debra; Sridharan, Shaum; Traylor, Katie; Wasserman‐Wincko, Tamara; Young, Kelly; Zandberg, Dan; Johnson, Jonas T. title: Prevision of multidisciplinary head and neck cancer survivorship care during the 2019 novel coronavirus pandemic date: 2020-05-18 journal: Head Neck DOI: 10.1002/hed.26256 sha: doc_id: 269205 cord_uid: g6eyvnou file: cache/cord-269289-6uog10j4.json key: cord-269289-6uog10j4 authors: Mabillard, Holly; Sayer, John A. title: Electrolyte Disturbances in SARS-CoV-2 Infection date: 2020-07-22 journal: F1000Res DOI: 10.12688/f1000research.24441.2 sha: doc_id: 269289 cord_uid: 6uog10j4 file: cache/cord-269564-r5mmsnbx.json key: cord-269564-r5mmsnbx authors: Hans, Diana; Kelly, Erin; Wilhelmson, Krista; Katz, Eric D. title: Rapidly Fatal Infections date: 2008-05-31 journal: Emergency Medicine Clinics of North America DOI: 10.1016/j.emc.2008.01.003 sha: doc_id: 269564 cord_uid: r5mmsnbx file: cache/cord-269275-b7xxk48t.json key: cord-269275-b7xxk48t authors: Tang, Xiaojia; Luo, Yuhan; Song, Yuxia; Fan, Hongyang; Dong, Sisi; Liu, Peipei; Chen, Yingzhu title: Neurological manifestations in COVID-19 and its possible mechanism date: 2020-09-27 journal: Aging (Albany NY) DOI: 10.18632/aging.103732 sha: doc_id: 269275 cord_uid: b7xxk48t file: cache/cord-269105-yuphgyrn.json key: cord-269105-yuphgyrn authors: Dumantepe, Mert; Aydın, Selim; Yildiz, Erdem; Okur, Hacer Kuzu; Kocagöz, A. Sesin; Gundogdu, Yasemin; Okten, Murat; Isbir, Selim; Karabulut, Hasan title: Subsegmental Thrombus in COVID-19 Pneumonia: Immunothrombosis or Pulmonary Embolism? Data Analysis of Hospitalised Patients With Coronavirus Disease date: 2020-08-24 journal: Heart Lung Circ DOI: 10.1016/j.hlc.2020.08.003 sha: doc_id: 269105 cord_uid: yuphgyrn file: cache/cord-268974-7bqh1yas.json key: cord-268974-7bqh1yas authors: Capitelli-McMahon, Helen; Hurley, Anna; Pinder, Richard; Matteucci, Paolo; Totty, Joshua title: Characterising non-melanoma skin cancer undergoing surgical management during the COVID-19 pandemic date: 2020-11-02 journal: J Plast Reconstr Aesthet Surg DOI: 10.1016/j.bjps.2020.10.042 sha: doc_id: 268974 cord_uid: 7bqh1yas file: cache/cord-270019-er70ehk4.json key: cord-270019-er70ehk4 authors: Yang, Kunyu; Sheng, Yuhan; Huang, Chaolin; Jin, Yang; Xiong, Nian; Jiang, Ke; Lu, Hongda; Liu, Jing; Yang, Jiyuan; Dong, Youhong; Pan, Dongfeng; Shu, Chengrong; Li, Jun; Wei, Jielin; Huang, Yu; Peng, Ling; Wu, Mengjiao; Zhang, Ruiguang; Wu, Bian; Li, Yuhui; Cai, Liqiong; Li, Guiling; Zhang, Tao; Wu, Gang title: Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study date: 2020-05-29 journal: Lancet Oncol DOI: 10.1016/s1470-2045(20)30310-7 sha: doc_id: 270019 cord_uid: er70ehk4 file: cache/cord-269345-5tlyy8jp.json key: cord-269345-5tlyy8jp authors: Minuz, Pietro; Mansueto, Giancarlo; Mazzaferri, Fulvia; Fava, Cristiano; Dalbeni, Andrea; Ambrosetti, Maria Chiara; Sibani, Marcella; Tacconelli, Evelina title: High rate of pulmonary thromboembolism in patients with SARS-CoV-2 pneumonia date: 2020-06-18 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2020.06.011 sha: doc_id: 269345 cord_uid: 5tlyy8jp file: cache/cord-269425-e9iyso7n.json key: cord-269425-e9iyso7n authors: Bhattacharjee, Sukrita; Banerjee, Mainak title: Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review date: 2020-09-19 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00521-8 sha: doc_id: 269425 cord_uid: e9iyso7n file: cache/cord-270079-vwnzp6zj.json key: cord-270079-vwnzp6zj authors: Galanis, Nikiforos; Stavraka, Chara; Agathangelidis, Filon; Petsatodis, Evangelos; Giankoulof, Christos; Givissis, Panagiotis title: Coagulopathy in COVID-19 infection: a case of acute upper limb ischemia date: 2020-07-02 journal: J Surg Case Rep DOI: 10.1093/jscr/rjaa204 sha: doc_id: 270079 cord_uid: vwnzp6zj file: cache/cord-269469-7pmnxi9a.json key: cord-269469-7pmnxi9a authors: Bikdeli, Behnood title: Anticoagulation in COVID-19: Randomized trials should set the balance between excitement and evidence date: 2020-10-08 journal: Thromb Res DOI: 10.1016/j.thromres.2020.09.033 sha: doc_id: 269469 cord_uid: 7pmnxi9a file: cache/cord-269554-fzu6dy4e.json key: cord-269554-fzu6dy4e authors: Hussein, M. H.; Toraih, E. A.; Attia, A. S.; Youssef, M.; Omar, M.; Burley, N.; Zhang, A. D.; Roos, J.; Houghton, A.; Aniemeka, N.; Shama, M. A.; Duchesne, J.; Kandil, E. title: Asthma in COVID-19: An extra chain fitting around the neck? date: 2020-07-15 journal: nan DOI: 10.1101/2020.07.13.20153130 sha: doc_id: 269554 cord_uid: fzu6dy4e file: cache/cord-269690-6r2bfydw.json key: cord-269690-6r2bfydw authors: De Lorenzo, Rebecca; Conte, Caterina; Lanzani, Chiara; Benedetti, Francesco; Roveri, Luisa; Mazza, Mario G.; Brioni, Elena; Giacalone, Giacomo; Canti, Valentina; Sofia, Valentina; D’Amico, Marta; Di Napoli, Davide; Ambrosio, Alberto; Scarpellini, Paolo; Castagna, Antonella; Landoni, Giovanni; Zangrillo, Alberto; Bosi, Emanuele; Tresoldi, Moreno; Ciceri, Fabio; Rovere-Querini, Patrizia title: Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study date: 2020-10-14 journal: PLoS One DOI: 10.1371/journal.pone.0239570 sha: doc_id: 269690 cord_uid: 6r2bfydw file: cache/cord-269503-ij4u980v.json key: cord-269503-ij4u980v authors: Amaratunga, Eluwana A; Corwin, Douglas S; Moran, Lynn; Snyder, Richard title: Bradycardia in Patients With COVID-19: A Calm Before the Storm? date: 2020-06-13 journal: Cureus DOI: 10.7759/cureus.8599 sha: doc_id: 269503 cord_uid: ij4u980v file: cache/cord-270294-g95skuik.json key: cord-270294-g95skuik authors: Johnstone, Jennie; Majumdar, Sumit R.; Fox, Julie D.; Marrie, Thomas J. title: Viral Infection in Adults Hospitalized With Community-Acquired Pneumonia Prevalence, Pathogens, and Presentation date: 2008-12-31 journal: Chest DOI: 10.1378/chest.08-0888 sha: doc_id: 270294 cord_uid: g95skuik file: cache/cord-270509-roc93m4f.json key: cord-270509-roc93m4f authors: Radhakrishnan, Suma; Perumbally, Hafees Abdullah; Surya, Sai; Ponneth, Mohammed Shareef title: Guidelines for Surgical Tracheostomy and Tracheostomy Tube Change During the COVID-19 Pandemic: A Review Article date: 2020-06-22 journal: Indian J Otolaryngol Head Neck Surg DOI: 10.1007/s12070-020-01893-y sha: doc_id: 270509 cord_uid: roc93m4f file: cache/cord-270153-krhkqcev.json key: cord-270153-krhkqcev authors: Khosla, Seema title: Implementation of Synchronous Telemedicine into Clinical Practice date: 2020-08-04 journal: Sleep Med Clin DOI: 10.1016/j.jsmc.2020.05.002 sha: doc_id: 270153 cord_uid: krhkqcev file: cache/cord-269591-lu415jcp.json key: cord-269591-lu415jcp authors: nan title: Recommendations Regarding COVID19 Infection in Rheumatic Patients in Greece date: 2020-03-31 journal: Mediterr J Rheumatol DOI: 10.31138/mjr.31.1.6 sha: doc_id: 269591 cord_uid: lu415jcp file: cache/cord-266713-rghowch1.json key: cord-266713-rghowch1 authors: Reyes-Bueno, JA; Mena-Vázquez, N; Ojea-Ortega, T; Gonzalez-Sotomayor, MM; Cabezudo-Garcia, P; Ciano-Petersen, NL; Pons-Pons, G; Castro-Sánchez, MV; Serrano-Castro, PJ title: Case fatality of COVID-19 in patients with neurodegenerative dementia date: 2020-10-07 journal: nan DOI: 10.1016/j.nrleng.2020.07.006 sha: doc_id: 266713 cord_uid: rghowch1 file: cache/cord-269981-xm0by310.json key: cord-269981-xm0by310 authors: Shen, Cheng; Jiang, Lisha; Ma, Hongsheng; Che, Guowei title: Perioperative preparation in thoracic day surgery: Battle against COVID‐19 date: 2020-06-17 journal: Thorac Cancer DOI: 10.1111/1759-7714.13500 sha: doc_id: 269981 cord_uid: xm0by310 file: cache/cord-270348-5804ffwx.json key: cord-270348-5804ffwx authors: Angelino, Andrew F.; Lyketsos, Constantine G.; Ahmed, M. Shafeeq; Potash, James B.; Cullen, Bernadette A. title: Design and implementation of a regional inpatient psychiatry unit for asymptomatic SARS-CoV-2 positive patients. date: 2020-07-02 journal: Psychosomatics DOI: 10.1016/j.psym.2020.06.018 sha: doc_id: 270348 cord_uid: 5804ffwx file: cache/cord-270124-tqhkzd2w.json key: cord-270124-tqhkzd2w authors: Campos, Fábio Guilherme; Fillmann, Henrique Sarubbi title: General recommendations to the colorectal surgeon during the COVID-19 pandemic date: 2020-06-19 journal: nan DOI: 10.1016/j.jcol.2020.06.001 sha: doc_id: 270124 cord_uid: tqhkzd2w file: cache/cord-270210-gfy2ytg5.json key: cord-270210-gfy2ytg5 authors: Drent, Marjolein; Elfferich, Marjon; Breedveld, Ellen; Vries, Jolanda De; Strookappe, Bert title: Benefit of Wearing an Activity Tracker in Sarcoidosis date: 2020-08-22 journal: J Pers Med DOI: 10.3390/jpm10030097 sha: doc_id: 270210 cord_uid: gfy2ytg5 file: cache/cord-270327-v4td3zsa.json key: cord-270327-v4td3zsa authors: Atallah, Bassam; Mallah, Saad I; AbdelWareth, Laila; AlMahmeed, Wael; Fonarow, Gregg C title: A Marker of Systemic Inflammation or Direct Cardiac Injury: Should Cardiac Troponin Levels be Monitored in COVID-19 Patients? date: 2020-04-29 journal: Eur Heart J Qual Care Clin Outcomes DOI: 10.1093/ehjqcco/qcaa033 sha: doc_id: 270327 cord_uid: v4td3zsa file: cache/cord-270525-nmebqrb1.json key: cord-270525-nmebqrb1 authors: Núñez-Velasco, Santiago; Mercado-Pimentel, Rodrigo; Plascencia, Miguel Ochoa; Rodríguez-Arias, Regina; Lopez-Espinoza, Gerardo; González-González, Maria Elena; Estrella-Sánchez, Carlos; Ramírez-Huerta, Carlos title: Response to SARS-CoV-2 Pandemic in a Non-COVID-19 Designated Latin-American Neurosurgery Department date: 2020-05-11 journal: World Neurosurg DOI: 10.1016/j.wneu.2020.05.019 sha: doc_id: 270525 cord_uid: nmebqrb1 file: cache/cord-269835-mz7i66qp.json key: cord-269835-mz7i66qp authors: Furfaro, Federica; Vuitton, Lucine; Fiorino, Gionata; Koch, Stephane; Allocca, Mariangela; Gilardi, Daniela; Zilli, Alessandra; D’Amico, Ferdinando; Radice, Simona; Chevaux, Jean-Baptiste; Schaefer, Marion; Chaussade, Stanislas; Danese, Silvio; Peyrin-Biroulet, Laurent title: SFED recommendations for IBD endoscopy during COVID-19 pandemic: Italian and French experience date: 2020-06-11 journal: Nat Rev Gastroenterol Hepatol DOI: 10.1038/s41575-020-0319-3 sha: doc_id: 269835 cord_uid: mz7i66qp file: cache/cord-269511-bfd1dmt3.json key: cord-269511-bfd1dmt3 authors: Salacup, Grace; Lo, Kevin Bryan; Gul, Fahad; Peterson, Eric; De Joy, Robert; Bhargav, Ruchika; Pelayo, Jerald; Albano, Jeri; Azmaiparashvili, Zurab; Benzaquen, Sadia; Patarroyo‐Aponte, Gabriel; Rangaswami, Janani title: Characteristics and Clinical Outcomes of COVID‐19 Patients in an Underserved‐Inner City Population: A Single Tertiary Center Cohort date: 2020-07-03 journal: J Med Virol DOI: 10.1002/jmv.26252 sha: doc_id: 269511 cord_uid: bfd1dmt3 file: cache/cord-270388-nozh463l.json key: cord-270388-nozh463l authors: Damiani, M.; Gandini, L.; Landi, F.; Fabretti, F.; Gritti, G.; Riva, I. title: Extracorporeal Cytokine Hemadsorption in Severe COVID-19 Respiratory Failure date: 2020-06-29 journal: nan DOI: 10.1101/2020.06.28.20133561 sha: doc_id: 270388 cord_uid: nozh463l file: cache/cord-270391-703js942.json key: cord-270391-703js942 authors: Rai, Harpreet K; John, Geevarghese; Anton, Maria title: Atypical Presentation of Panhypopituitarism date: 2020-07-09 journal: Cureus DOI: 10.7759/cureus.9102 sha: doc_id: 270391 cord_uid: 703js942 file: cache/cord-269776-hj1s3ipp.json key: cord-269776-hj1s3ipp authors: Agostoni, Angelo; Aygören-Pürsün, Emel; Binkley, Karen E.; Blanch, Alvaro; Bork, Konrad; Bouillet, Laurence; Bucher, Christoph; Castaldo, Anthony J; Cicardi, Marco; Davis, Alvin E; De Carolis, Caterina; Drouet, Christian; Duponchel, Christiane; Farkas, Henriette; Fáy, Kálmán; Fekete, Béla; Fischer, Bettina; Fontana, Luigi; Füst, George; Giacomelli, Roberto; Gröner, Albrecht; Erik Hack, C.; Harmat, George; Jakenfelds, John; Juers, Mathias; Kalmár, Lajos; Kaposi, Pál N.; Karádi, István; Kitzinger, Arianna; Kollár, Tímea; Kreuz, Wolfhart; Lakatos, Peter; Longhurst, Hilary J.; Lopez-Trascasa, Margarita; Martinez-Saguer, Inmaculada; Monnier, Nicole; Nagy, István; Németh, Éva; Nielsen, Erik Waage; Nuijens, Jan H.; O'Grady, Caroline; Pappalardo, Emanuela; Penna, Vincenzo; Perricone, Carlo; Perricone, Roberto; Rauch, Ursula; Roche, Olga; Rusicke, Eva; Späth, Peter J; Szendei, George; Takács, Edit; Tordai, Attila; Truedsson, Lennart; Varga, Lilian; Visy, Beáta; Williams, Kayla; Zanichelli, Andrea; Zingale, Lorenza title: Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond date: 2004-09-11 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2004.06.047 sha: doc_id: 269776 cord_uid: hj1s3ipp file: cache/cord-270712-v6nnnzhm.json key: cord-270712-v6nnnzhm authors: Woodcock, J. A. title: Test, test, test! date: 2020-06-26 journal: Br Dent J DOI: 10.1038/s41415-020-1800-7 sha: doc_id: 270712 cord_uid: v6nnnzhm file: cache/cord-270776-oulnk1b3.json key: cord-270776-oulnk1b3 authors: Chau, Tai-nin; Lee, Po-oi; Choi, Kin-wing; Lee, Chiu-man; Ma, Ka-fai; Tsang, Tak-yin; Tso, Yuk-keung; Chiu, Ming-chee; Tong, Wing-lok; Yu, Wai-cho; Lai, Sik-to title: Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome date: 2004-08-15 journal: The American Journal of Medicine DOI: 10.1016/j.amjmed.2004.03.020 sha: doc_id: 270776 cord_uid: oulnk1b3 file: cache/cord-270654-cz2y6ta9.json key: cord-270654-cz2y6ta9 authors: Deftereos, Spyridon G.; Siasos, Gerasimos; Giannopoulos, Georgios; Vrachatis, Dimitrios A.; Angelidis, Christos; Giotaki, Sotiria G.; Gargalianos, Panagiotis; Giamarellou, Helen; Gogos, Charalampos; Daikos, Georgios; Lazanas, Marios; Lagiou, Pagona; Saroglou, Georgios; Sipsas, Nikolaos; Tsiodras, Sotirios; Chatzigeorgiou, Dimitrios; Moussas, Nikolaos; Kotanidou, Anastasia; Koulouris, Nikolaos; Oikonomou, Evangelos; Kaoukis, Andreas; Kossyvakis, Charalampos; Raisakis, Konstantinos; Fountoulaki, Katerina; Comis, Mihalis; Tsiachris, Dimitrios; Sarri, Eleni; Theodorakis, Andreas; Martinez-Dolz, Luis; Sanz-Sánchez, Jorge; Reimers, Bernhard; Stefanini, Giulio G.; Cleman, Michael; Filippou, Dimitrios; Olympios, Christoforos D.; Pyrgakis, Vlasios N.; Goudevenos, John; Hahalis, George; Kolettis, Theofilos M.; Iliodromitis, Efstathios; Tousoulis, Dimitrios; Stefanadis, Christodoulos title: The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design date: 2020-04-03 journal: Hellenic J Cardiol DOI: 10.1016/j.hjc.2020.03.002 sha: doc_id: 270654 cord_uid: cz2y6ta9 file: cache/cord-270665-z4l3lq39.json key: cord-270665-z4l3lq39 authors: Tian, Qing; Yan, Xiaodong; Shi, Rui; Wang, Guijie; Xu, Xiaomei; Wang, Hongyan; Wang, Qingqing; Yang, Long; Liu, Zirong; Wang, Lanying; Shrestha, Dhan Bahadur; Zhang, Yamin title: Endoscopic mask innovation and protective measures changes during the COVID‐19 pandemic: experience from a Chinese hepato‐biliary‐pancreatic unit date: 2020-07-23 journal: Dig Endosc DOI: 10.1111/den.13799 sha: doc_id: 270665 cord_uid: z4l3lq39 file: cache/cord-271603-zy4l9vtf.json key: cord-271603-zy4l9vtf authors: Skali, Hicham; Murthy, Venkatesh L.; Paez, Diana; Choi, Elisa M.; Keng, Felix Y. J.; Iain, McGhie A.; Al-Mallah, Mouaz; Campisi, Roxana; Bateman, Timothy M.; Carrio, Ignasi; Beanlands, Rob; Calnon, Dennis A.; Dilsizian, Vasken; Dondi, Maurizio; Gimelli, Alessia; Pagnanelli, Robert; Polk, Donna M.; Soman, Prem; Einstein, Andrew J.; Dorbala, Sharmila; Thompson, Randall C. title: Guidance and Best Practices for Reestablishment of Non-Emergent Care in Nuclear Cardiology Laboratories During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Information Statement from ASNC, IAEA, and SNMMI date: 2020-10-17 journal: J Nucl Med DOI: 10.2967/jnumed.120.251355 sha: doc_id: 271603 cord_uid: zy4l9vtf file: cache/cord-270245-zziwb2jy.json key: cord-270245-zziwb2jy authors: Russell, Beth; Moss, Charlotte; Papa, Sophie; Irshad, Sheeba; Ross, Paul; Spicer, James; Kordasti, Shahram; Crawley, Danielle; Wylie, Harriet; Cahill, Fidelma; Haire, Anna; Zaki, Kamarul; Rahman, Fareen; Sita-Lumsden, Ailsa; Josephs, Debra; Enting, Deborah; Lei, Mary; Ghosh, Sharmistha; Harrison, Claire; Swampillai, Angela; Sawyer, Elinor; D'Souza, Andrea; Gomberg, Simon; Fields, Paul; Wrench, David; Raj, Kavita; Gleeson, Mary; Bailey, Kate; Dillon, Richard; Streetly, Matthew; Rigg, Anne; Sullivan, Richard; Dolly, Saoirse; Van Hemelrijck, Mieke title: Factors Affecting COVID-19 Outcomes in Cancer Patients: A First Report From Guy's Cancer Center in London date: 2020-07-22 journal: Front Oncol DOI: 10.3389/fonc.2020.01279 sha: doc_id: 270245 cord_uid: zziwb2jy file: cache/cord-270763-idkylpb6.json key: cord-270763-idkylpb6 authors: Fontes, Cristina Asvolinsque Pantaleão; dos Santos, Alair Augusto Sarmet Moreira Damas; de Oliveira, Solange Artimos; Aidê, Miquel Abdon title: Influenza A virus H1N1 associated pneumonia - acute and late aspects evaluated with high resolution tomography in hospitalized patients date: 2020-09-30 journal: Multidiscip Respir Med DOI: 10.4081/mrm.2020.692 sha: doc_id: 270763 cord_uid: idkylpb6 file: cache/cord-270723-cjfglili.json key: cord-270723-cjfglili authors: Fteiha, Bashar; Karameh, Hani; Kurd, Ramzi; Ziff‐Werman, Batsheva; Feldman, Itamar; Bnaya, Alon; Einav, Sharon; Orlev, Amir; Ben‐Chetrit, Eli title: QTc prolongation among hydroxychloroquine sulfate‐treated COVID‐19 patients: An observational study date: 2020-10-15 journal: Int J Clin Pract DOI: 10.1111/ijcp.13767 sha: doc_id: 270723 cord_uid: cjfglili file: cache/cord-270740-3su8pc3f.json key: cord-270740-3su8pc3f authors: Sultan, Sherif; Sultan, Mohamed title: COVID-19 Cytokine Storm and Novel Truth date: 2020-05-22 journal: Med Hypotheses DOI: 10.1016/j.mehy.2020.109875 sha: doc_id: 270740 cord_uid: 3su8pc3f file: cache/cord-270876-kul6bs3w.json key: cord-270876-kul6bs3w authors: Morris, Nathaniel P. title: Virtual Visits and the Future of No-Shows date: 2020-06-08 journal: J Gen Intern Med DOI: 10.1007/s11606-020-05948-2 sha: doc_id: 270876 cord_uid: kul6bs3w file: cache/cord-270933-ecmg8kti.json key: cord-270933-ecmg8kti authors: Ali, Ashaq; Siddique, Rabeea; Shi, Hongwei; Shabana; Khan, Suliman; Hu, Junjie; Zaman, Wajid; Wang, Tiejun; Dong, Men; Han, Guang title: COVID-19: Clinical aspects and therapeutics responses date: 2020-07-03 journal: Saudi Pharm J DOI: 10.1016/j.jsps.2020.06.022 sha: doc_id: 270933 cord_uid: ecmg8kti file: cache/cord-271358-5666nsb9.json key: cord-271358-5666nsb9 authors: Roncon, Loris; Zuin, Marco; Rigatelli, Gianluca title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-06 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02358-4 sha: doc_id: 271358 cord_uid: 5666nsb9 file: cache/cord-271180-cnrs0zpg.json key: cord-271180-cnrs0zpg authors: Rizvi, Saniya; Danic, Michael; Silver, Mark; LaBond, Virginia title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date: 2020-09-18 journal: Heart Lung DOI: 10.1016/j.hrtlng.2020.09.007 sha: doc_id: 271180 cord_uid: cnrs0zpg file: cache/cord-271149-qnhlfozo.json key: cord-271149-qnhlfozo authors: Huo, Xiang; Chen, Li-Ling; Hong, Lei; Xiang, Lun-Hui; Tang, Fen-Yang; Chen, Shan-Hui; Gao, Qiang; Chen, Cong; Dai, Qi-gang; Sun, Chuan-Wu; Xu, Ke; Dai, Wen-Jun; Qi, Xian; Li, Chang-Cheng; Yu, Hui-Yan; Zhou, Yin; Huang, Hao-Di; Pan, Xing-Yang; Xu, Chang-sha; Zhou, Ming-Hao; Bao, Chang-Jun title: Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014 date: 2016-09-01 journal: Infect Dis Poverty DOI: 10.1186/s40249-016-0170-5 sha: doc_id: 271149 cord_uid: qnhlfozo file: cache/cord-270799-2pmpspuj.json key: cord-270799-2pmpspuj authors: Zayet, Souheil; Kadiane-Oussou, N’dri Juliette; Lepiller, Quentin; Zahra, Hajer; Royer, Pierre-Yves; Toko, Lynda; Gendrin, Vincent; Klopfenstein, Timothée title: Clinical features of COVID-19 and influenza: A comparative study on Nord Franche-Comte cluster date: 2020-06-16 journal: Microbes Infect DOI: 10.1016/j.micinf.2020.05.016 sha: doc_id: 270799 cord_uid: 2pmpspuj file: cache/cord-271220-sntawlnf.json key: cord-271220-sntawlnf authors: Tadic, Marijana; Cuspidi, Cesare; Sala, Carla title: COVID‐19 and diabetes: Is there enough evidence? date: 2020-05-29 journal: J Clin Hypertens (Greenwich) DOI: 10.1111/jch.13912 sha: doc_id: 271220 cord_uid: sntawlnf file: cache/cord-270628-jtj30v0r.json key: cord-270628-jtj30v0r authors: Alharthy, Abdulrahman; Faqihi, Fahad; Abuhamdah, Mohamed; Noor, Alfateh; Naseem, Nasir; Balhamar, Abdullah; Al Saud, Ahad Alhassan Al Saud Bin Abdulaziz; Brindley, Peter G.; Memish, Ziad A.; Karakitsos, Dimitrios; Blaivas, Michael title: Prospective Longitudinal Evaluation of Point‐of‐Care Lung Ultrasound in Critically Ill Patients With Severe COVID‐19 Pneumonia date: 2020-08-14 journal: J Ultrasound Med DOI: 10.1002/jum.15417 sha: doc_id: 270628 cord_uid: jtj30v0r file: cache/cord-271262-xglhx928.json key: cord-271262-xglhx928 authors: Ghia, Samit; Lazar, Michael; Epstein, Jonathan; Bhatt, Himani V. title: “ANESTHESIA STAT” TO INTUBATE A COVID-19 PATIENT: IMPLICATIONS FOR THE ANESTHESIOLOGIST date: 2020-05-15 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.05.016 sha: doc_id: 271262 cord_uid: xglhx928 file: cache/cord-271887-blwrpf38.json key: cord-271887-blwrpf38 authors: Sampa, Masuda Begum; Hoque, Md. Rakibul; Islam, Rafiqul; Nishikitani, Mariko; Nakashima, Naoki; Yokota, Fumihiko; Kikuchi, Kimiyo; Rahman, Md Moshiur; Shah, Faiz; Ahmed, Ashir title: Redesigning Portable Health Clinic Platform as a Remote Healthcare System to Tackle COVID-19 Pandemic Situation in Unreached Communities date: 2020-06-30 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17134709 sha: doc_id: 271887 cord_uid: blwrpf38 file: cache/cord-271212-y8denvju.json key: cord-271212-y8denvju authors: Xu, Xia; Yu, Mu-Qing; Shen, Qian; Wang, Lian-Zhong; Yan, Rong-Di; Zhang, Meng-Yu; Liu, Jian-Yu; Qu, Yi-Qing title: Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China date: 2020-07-25 journal: Int J Med Sci DOI: 10.7150/ijms.47935 sha: doc_id: 271212 cord_uid: y8denvju file: cache/cord-271660-5sfkhg19.json key: cord-271660-5sfkhg19 authors: Sun, Hsin-Yun; Wang, Jann-Yuan; Chen, Yee-Chun; Hsueh, Po-Ren; Chen, Yi-Hsuan; Chuang, Yu-Chung; Fang, Chi-Tai; Chang, Shan-Chwen; Wang, Jung-Der title: Impact of introducing fluorescent microscopy on hospital tuberculosis control: A before-after study at a high caseload medical center in Taiwan date: 2020-04-03 journal: PLoS One DOI: 10.1371/journal.pone.0230067 sha: doc_id: 271660 cord_uid: 5sfkhg19 file: cache/cord-271871-8grkln6o.json key: cord-271871-8grkln6o authors: Singer, J. S.; Cheng, E. M.; Murad, D.; de St. Maurice, A.; Hines, O. J.; Uslan, D. Z.; Garner, O.; Pregler, J.; Bukata, S. V.; Pfeffer, M. A.; Cherry, R. A. title: Low Prevalence (0.13%) of COVID-19 Infection in Asymptomatic Pre-operative/Pre-procedure Patients at a Large Academic Medical Center Informs Approaches to Perioperative Care date: 2020-08-14 journal: Surgery DOI: 10.1016/j.surg.2020.07.048 sha: doc_id: 271871 cord_uid: 8grkln6o file: cache/cord-271896-1ad18z11.json key: cord-271896-1ad18z11 authors: Janowitz, Tobias; Gablenz, Eva; Pattinson, David; Wang, Timothy C; Conigliaro, Joseph; Tracey, Kevin; Tuveson, David title: Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series date: 2020-06-04 journal: Gut DOI: 10.1136/gutjnl-2020-321852 sha: doc_id: 271896 cord_uid: 1ad18z11 file: cache/cord-271920-1dzkgt6w.json key: cord-271920-1dzkgt6w authors: Carpenter, Christopher R.; Mudd, Philip; West, Colin P.; Wilber, Erin; Wilber, Scott T. title: Diagnosing COVID‐19 in the Emergency Department: A Scoping Review of Clinical Exam, Labs, Imaging Accuracy and Biases date: 2020-06-16 journal: Acad Emerg Med DOI: 10.1111/acem.14048 sha: doc_id: 271920 cord_uid: 1dzkgt6w file: cache/cord-272427-jqs00ilp.json key: cord-272427-jqs00ilp authors: Li, Yu-xuan; He, Chang-zheng; Liu, Yi-chen; Zhao, Peng-yue; Xu, Xiao-lei; Wang, Yu-feng; Xia, Shao-you; Du, Xiao-hui title: The impact of COVID-19 on gastric cancer surgery: a single-center retrospective study date: 2020-10-02 journal: BMC Surg DOI: 10.1186/s12893-020-00885-7 sha: doc_id: 272427 cord_uid: jqs00ilp file: cache/cord-271944-oxtus5vb.json key: cord-271944-oxtus5vb authors: Joseph, Rudman; Narula, Naureen; Daouk, Aref; Katyal, Nakul; Acharya, Sudeep; Avula, Akshay; Maroun, Rabih title: Seizure And COVID-19: Association and Review of Potential Mechanism date: 2020-10-13 journal: Neurol Psychiatry Brain Res DOI: 10.1016/j.npbr.2020.10.001 sha: doc_id: 271944 cord_uid: oxtus5vb file: cache/cord-272071-445ivhx0.json key: cord-272071-445ivhx0 authors: Wunsch, Hannah title: Mechanical Ventilation in COVID-19: Interpreting the Current Epidemiology date: 2020-07-01 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202004-1385ed sha: doc_id: 272071 cord_uid: 445ivhx0 file: cache/cord-272143-6ej3eibd.json key: cord-272143-6ej3eibd authors: Benavides‐Nieto, Marta; Méndez‐Echevarría, Ana; del Rosal, Teresa; García‐García, María Luz; Casas, Inmaculada; Pozo, Francisco; de la Serna, Olga; Lopez‐Granados, Eduardo; Rodriguez‐Pena, Rebeca; Calvo, Cristina title: The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy date: 2018-12-21 journal: Pediatr Pulmonol DOI: 10.1002/ppul.24214 sha: doc_id: 272143 cord_uid: 6ej3eibd file: cache/cord-272318-8yfg1j0o.json key: cord-272318-8yfg1j0o authors: Reddy, Sujan T.; Garg, Tanu; Shah, Chintan; Nascimento, Fábio A.; Imran, Rajeel; Kan, Peter; Bowry, Ritvij; Gonzales, Nicole; Barreto, Andrew; Kumar, Abhay; Volpi, John; Misra, Vivek; Chiu, David; Gadhia, Rajan; Savitz, Sean I. title: Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series date: 2020-06-11 journal: Case Rep Neurol DOI: 10.1159/000508958 sha: doc_id: 272318 cord_uid: 8yfg1j0o file: cache/cord-272553-bcmta2he.json key: cord-272553-bcmta2he authors: Wang, Zhiqiang; Wang, Zhigang; Xiong, Guoping title: Clinical characteristics and laboratory results of pregnant women with COVID‐19 in Wuhan, China date: 2020-07-03 journal: Int J Gynaecol Obstet DOI: 10.1002/ijgo.13265 sha: doc_id: 272553 cord_uid: bcmta2he file: cache/cord-272727-a5ngjuyz.json key: cord-272727-a5ngjuyz authors: Bertsimas, D.; Boussioux, L.; Cory Wright, R.; Delarue, A.; Digalakis, V.; Jacquillat, A.; Lahlou Kitane, D.; Lukin, G.; Li, M. L.; Mingardi, L.; Nohadani, O.; Orfanoudaki, A.; Papalexopoulos, T.; Paskov, I.; Pauphilet, J.; Skali Lami, O.; Stellato, B.; Tazi Bouardi, H.; Villalobos Carballo, K.; Wiberg, H.; Zeng, C. title: From predictions to prescriptions: A data-drivenresponse to COVID-19 date: 2020-06-29 journal: nan DOI: 10.1101/2020.06.26.20141127 sha: doc_id: 272727 cord_uid: a5ngjuyz file: cache/cord-272585-346ef6qy.json key: cord-272585-346ef6qy authors: Lombardi, JM; Bottiglieri, T; Desai, N; Riew, KD; Boddapati, V; Weller, M; Bourgois, C; McChrystal, S; Lehman, RA title: Addressing a National Crisis: The Spine Hospital and Department's Response to the COVID-19 Pandemic in New York City date: 2020-05-31 journal: Spine J DOI: 10.1016/j.spinee.2020.05.539 sha: doc_id: 272585 cord_uid: 346ef6qy file: cache/cord-271483-33kuvpl7.json key: cord-271483-33kuvpl7 authors: Shojaei, Amirahmad; Salari, Pooneh title: COVID-19 and off label use of drugs: an ethical viewpoint date: 2020-05-08 journal: Daru DOI: 10.1007/s40199-020-00351-y sha: doc_id: 271483 cord_uid: 33kuvpl7 file: cache/cord-272135-a09bf50o.json key: cord-272135-a09bf50o authors: Brouqui, Philippe; Puro, Vincenzo; Fusco, Francesco M; Bannister, Barbara; Schilling, Stephan; Follin, Per; Gottschalk, René; Hemmer, Robert; Maltezou, Helena C; Ott, Kristi; Peleman, Renaat; Perronne, Christian; Sheehan, Gerard; Siikamäki, Heli; Skinhoj, Peter; Ippolito, Giuseppe title: Infection control in the management of highly pathogenic infectious diseases: consensus of the European Network of Infectious Disease date: 2009-04-22 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(09)70070-2 sha: doc_id: 272135 cord_uid: a09bf50o file: cache/cord-272154-nrm9ulj5.json key: cord-272154-nrm9ulj5 authors: Gupta, Ravi; Kumar, V. Mohan; Tripathi, Manjari; Datta, Karuna; Narayana, Manjunatha; Ranjan Sarmah, Kripesh; Bhatia, Manvir; Devnani, Preeti; Das, Sourav; Shrivastava, Deepak; Gourineni, Rama Devi; Singh, Tripat Deep; Jindal, Apar; Mallick, Hruda Nanda title: Guidelines of the Indian Society for Sleep Research (ISSR) for Practice of Sleep Medicine during COVID-19 date: 2020-07-04 journal: Sleep Vigil DOI: 10.1007/s41782-020-00097-2 sha: doc_id: 272154 cord_uid: nrm9ulj5 file: cache/cord-272419-y3ebt4jm.json key: cord-272419-y3ebt4jm authors: Monari, Caterina; Gentile, Valeria; Camaioni, Clarissa; Marino, Giulia; Coppola, Nicola title: A Focus on the Nowadays Potential Antiviral Strategies in Early Phase of Coronavirus Disease 2019 (Covid-19): A Narrative Review date: 2020-08-09 journal: Life (Basel) DOI: 10.3390/life10080146 sha: doc_id: 272419 cord_uid: y3ebt4jm file: cache/cord-272112-egsha2j7.json key: cord-272112-egsha2j7 authors: Tartarone, Alfredo; Lerose, Rosa title: COVID-19 and cancer care: what do international guidelines say? date: 2020-08-07 journal: Med Oncol DOI: 10.1007/s12032-020-01406-5 sha: doc_id: 272112 cord_uid: egsha2j7 file: cache/cord-272655-qeojdpez.json key: cord-272655-qeojdpez authors: Remolina, Yuly Andrea; Ulloa, María Mercedes; Vargas, Hernán; Díaz, Liliana; Gómez, Sandra Liliana; Saavedra, Alfredo; Sánchez, Edgar; Cortés, Jorge Alberto title: Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia date: 2015-11-17 journal: PLoS One DOI: 10.1371/journal.pone.0143152 sha: doc_id: 272655 cord_uid: qeojdpez file: cache/cord-272975-gzsd4ybt.json key: cord-272975-gzsd4ybt authors: Antony, Arun; Haneef, Zulfi title: Systematic review of EEG findings in 617 patients diagnosed with COVID-19 date: 2020-10-19 journal: Seizure DOI: 10.1016/j.seizure.2020.10.014 sha: doc_id: 272975 cord_uid: gzsd4ybt file: cache/cord-273090-fdzkfo1u.json key: cord-273090-fdzkfo1u authors: He, Susu; Zhou, Chao; Lu, Dongqing; Yang, Haihua; XU, Hailing; Wu, Guixian; Pan, Weijia; Zhu, Rui; Jia, HaiJian; Tang, Xinni; Chen, Xi; Wu, Xiaomai title: Relationship between Chest CT manifestations and immune response in COVID-19 patients date: 2020-06-20 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.06.059 sha: doc_id: 273090 cord_uid: fdzkfo1u file: cache/cord-272630-2na1gndu.json key: cord-272630-2na1gndu authors: Benito, Daniel A.; Pasick, Luke; Mulcahy, Collin F.; Rajasekaran, Karthik; Todd-Hesham, Hosai; Joshi, Arjun S.; Goodman, Joseph F.; Thakkar, Punam title: Local spikes in COVID-19 cases: Recommendations for maintaining otolaryngology clinic operations date: 2020-08-20 journal: Am J Otolaryngol DOI: 10.1016/j.amjoto.2020.102688 sha: doc_id: 272630 cord_uid: 2na1gndu file: cache/cord-272677-6t9kl3hq.json key: cord-272677-6t9kl3hq authors: Wu, w.; xu, z.; Jin, y.; Pan, a. title: Key Points of Clinical and CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) Imported Pneumonia Based On 21 Cases Analysis date: 2020-03-06 journal: nan DOI: 10.1101/2020.03.03.20030775 sha: doc_id: 272677 cord_uid: 6t9kl3hq file: cache/cord-272778-aixiioii.json key: cord-272778-aixiioii authors: Chen, Qingqing; Zheng, Zhencang; Zhang, Chao; Zhang, Xijiang; Wu, Huijuan; Wang, Jingdong; Wang, Shuwei; Zheng, Cheng title: Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China date: 2020-04-28 journal: Infection DOI: 10.1007/s15010-020-01432-5 sha: doc_id: 272778 cord_uid: aixiioii file: cache/cord-273045-ele1cz86.json key: cord-273045-ele1cz86 authors: Johnson, Claire D.; Green, Bart N.; Konarski-Hart, Karen K.; Hewitt, Elise G.; Napuli, Jason G.; Foshee, William K.; Brown, Jason W.; Kopansky-Giles, Deborah; Stuber, Kent J.; Lerede, Caterina; Charlton, Scott T.; Field, Jonathan R.; Botelho, Marcelo B.; Da Silva, Kendrah L.; Tønner, Gitte; Yap, Terrence BK.; Gkolfinopoulos, Vasileios S.; Quintero, Gabriel; Agaoglu, Mustafa H. title: Response of Practicing Chiropractors during the Early Phase of the COVID-19 Pandemic: A Descriptive Report date: 2020-06-13 journal: J Manipulative Physiol Ther DOI: 10.1016/j.jmpt.2020.05.001 sha: doc_id: 273045 cord_uid: ele1cz86 file: cache/cord-273426-55vu6b3u.json key: cord-273426-55vu6b3u authors: Iba, Toshiaki; Levy, Jerrold H.; Levi, Marcel; Connors, Jean Marie; Thachil, Jecko title: Coagulopathy of Coronavirus Disease 2019 date: 2020-05-26 journal: Crit Care Med DOI: 10.1097/ccm.0000000000004458 sha: doc_id: 273426 cord_uid: 55vu6b3u file: cache/cord-272976-pb2bjpop.json key: cord-272976-pb2bjpop authors: Washington, Lacey; Khan, Arfa; Mohammed, Tan-Lucien; Batra, Poonam V.; Gurney, Jud W.; Haramati, Linda B.; Jeudy, Jean; MacMahon, Heber; Rozenshtein, Anna; Vydareny, Kay H.; Kaiser, Larry; Raoof, Suhail title: ACR Appropriateness Criteria(®) on Acute Respiratory Illness date: 2009-10-01 journal: J Am Coll Radiol DOI: 10.1016/j.jacr.2009.06.022 sha: doc_id: 272976 cord_uid: pb2bjpop file: cache/cord-273641-8l57mnjt.json key: cord-273641-8l57mnjt authors: Sadr, Sara; SeyedAlinaghi, SeyedAhmad; Ghiasvand, Fereshteh; Hassan Nezhad, Malihe; Javadian, Nina; Hossienzade, Roghieh; Jafari, Fatemeh title: Isolated severe thrombocytopenia in a patient with COVID-19: A case report date: 2020-05-29 journal: IDCases DOI: 10.1016/j.idcr.2020.e00820 sha: doc_id: 273641 cord_uid: 8l57mnjt file: cache/cord-273091-40gda9n9.json key: cord-273091-40gda9n9 authors: Marrie, Thomas J. title: Empiric treatment of ambulatory community-acquired pneumonia: always include treatment for atypical agents date: 2005-03-01 journal: Infect Dis Clin North Am DOI: 10.1016/j.idc.2004.07.002 sha: doc_id: 273091 cord_uid: 40gda9n9 file: cache/cord-273602-cq276tj8.json key: cord-273602-cq276tj8 authors: Bavishi, Chirag; Bonow, Robert O.; Trivedi, Vrinda; Abbott, J. Dawn; Messerli, Franz H.; Bhatt, Deepak L. title: Acute myocardial injury in patients hospitalized with COVID-19 infection: A review date: 2020-06-06 journal: Prog Cardiovasc Dis DOI: 10.1016/j.pcad.2020.05.013 sha: doc_id: 273602 cord_uid: cq276tj8 file: cache/cord-273869-buavj9mm.json key: cord-273869-buavj9mm authors: Rosés-Gibert, Pau; Gimeno Castillo, Javier; Saenz Aguirre, Amaia; De la Torre Gomar, Francisco Javier; Carnero González, Lucía; Martinez de Lagrán Alvarez de Arcaya, Zuriñe; Gonzalez-Perez, Ricardo title: Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain date: 2020-09-08 journal: World J Pediatr DOI: 10.1007/s12519-020-00390-0 sha: doc_id: 273869 cord_uid: buavj9mm file: cache/cord-273119-jfy0iviy.json key: cord-273119-jfy0iviy authors: Julka-Anderson, Naman title: How COVID-19 is testing and evolving our communication skills date: 2020-06-25 journal: J Med Imaging Radiat Sci DOI: 10.1016/j.jmir.2020.06.008 sha: doc_id: 273119 cord_uid: jfy0iviy file: cache/cord-273283-gb0m6fue.json key: cord-273283-gb0m6fue authors: Altschul, David J.; Unda, Santiago R.; Benton, Joshua; de la Garza Ramos, Rafael; Cezayirli, Phillip; Mehler, Mark; Eskandar, Emad N. title: A novel severity score to predict inpatient mortality in COVID-19 patients date: 2020-10-07 journal: Sci Rep DOI: 10.1038/s41598-020-73962-9 sha: doc_id: 273283 cord_uid: gb0m6fue file: cache/cord-273175-bao8xxe2.json key: cord-273175-bao8xxe2 authors: Tran, Viet-Thi; Ravaud, Philippe title: COVID-19–related perceptions, context and attitudes of adults with chronic conditions: Results from a cross-sectional survey nested in the ComPaRe e-cohort date: 2020-08-06 journal: PLoS One DOI: 10.1371/journal.pone.0237296 sha: doc_id: 273175 cord_uid: bao8xxe2 file: cache/cord-273567-8fp3a9h8.json key: cord-273567-8fp3a9h8 authors: Zipprich, Hannah M.; Teschner, Ulrike; Witte, Otto W.; Schönenberg, Aline; Prell, Tino title: Knowledge, Attitudes, Practices, and Burden During the COVID-19 Pandemic in People with Parkinson’s Disease in Germany date: 2020-05-29 journal: J Clin Med DOI: 10.3390/jcm9061643 sha: doc_id: 273567 cord_uid: 8fp3a9h8 file: cache/cord-273875-vpp0l6ij.json key: cord-273875-vpp0l6ij authors: Johnson, Miguel; Cubison, Tania; Bonomi, Riccardo title: Creating a ‘safe haven’ for the most vulnerable; Early Reports of Management Strategies for Breast Cancer Patients in the UK during the COVID -19 Pandemic times date: 2020-09-20 journal: J Plast Reconstr Aesthet Surg DOI: 10.1016/j.bjps.2020.08.144 sha: doc_id: 273875 cord_uid: vpp0l6ij file: cache/cord-273929-kpcmy9x8.json key: cord-273929-kpcmy9x8 authors: Shah, Jatin P. title: The impact of COVID‐19 on Head and Neck surgery, education, and training date: 2020-04-25 journal: Head Neck DOI: 10.1002/hed.26188 sha: doc_id: 273929 cord_uid: kpcmy9x8 file: cache/cord-273695-p5p7kvpp.json key: cord-273695-p5p7kvpp authors: Fominskiy, Evgeny V.; Scandroglio, Anna Mara; Monti, Giacomo; Calabrò, Maria Grazia; Landoni, Giovanni; Dell'Acqua, Antonio; Beretta, Luigi; Moizo, Elena; Ravizza, Alfredo; Monaco, Fabrizio; Campochiaro, Corrado; Pieri, Marina; Azzolini, Maria Luisa; Borghi, Giovanni; Crivellari, Martina; Conte, Caterina; Mattioli, Cristina; Silvani, Paolo; Mucci, Milena; Turi, Stefano; Tentori, Stefano; Baiardo Redaelli, Martina; Sartorelli, Marianna; Angelillo, Piera; Belletti, Alessandro; Nardelli, Pasquale; Nisi, Francesco Giuseppe; Valsecchi, Gabriele; Barberio, Cristina; Ciceri, Fabio; Serpa Neto, Ary; Dagna, Lorenzo; Bellomo, Rinaldo; Zangrillo, Alberto title: Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy date: 2020-07-13 journal: Blood Purif DOI: 10.1159/000508657 sha: doc_id: 273695 cord_uid: p5p7kvpp file: cache/cord-273408-jtpaue0z.json key: cord-273408-jtpaue0z authors: Romeyke, Tobias; Noehammer, Elisabeth; Stummer, Harald title: COVID-19 Case Report: An 84-Year-Old Man with Exacerbation of Multiple Comorbidities Due to COVID-19 Managed by a Multidisciplinary Team Using Patient-Reported Outcomes date: 2020-08-21 journal: Am J Case Rep DOI: 10.12659/ajcr.926694 sha: doc_id: 273408 cord_uid: jtpaue0z file: cache/cord-273587-nja58vxw.json key: cord-273587-nja58vxw authors: Rendeiro, A. F.; Casano, J.; Vorkas, C. K.; Singh, H.; Morales, A.; DeSimone, R. A.; Ellsworth, G. B.; Soave, R.; Kapadia, S. N.; Saito, K.; Brown, C. D.; Hsu, J.; Kyriakides, C.; Chui, S.; Cappelli, L.; Cacciapuoti, M. T.; Tam, W.; Galluzzi, L.; Simonson, P. D.; Elemento, O.; Salvatore, M.; Inghirami, G. title: Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression date: 2020-09-09 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.09.08.20189092 sha: doc_id: 273587 cord_uid: nja58vxw file: cache/cord-274199-3stjueja.json key: cord-274199-3stjueja authors: Baldi, Enrico; Sechi, Giuseppe Maria; Mare, Claudio; Canevari, Fabrizio; Brancaglione, Antonella; Primi, Roberto; Klersy, Catherine; Palo, Alessandra; Contri, Enrico; Ronchi, Vincenza; Beretta, Giorgio; Reali, Francesca; Parogni, Pierpaolo; Facchin, Fabio; Rizzi, Ugo; Bussi, Daniele; Ruggeri, Simone; Oltrona Visconti, Luigi; Savastano, Simone title: COVID-19 kills at home: the close relationship between the epidemic and the increase of out-of-hospital cardiac arrests date: 2020-06-20 journal: Eur Heart J DOI: 10.1093/eurheartj/ehaa508 sha: doc_id: 274199 cord_uid: 3stjueja file: cache/cord-273614-qmp2tqtb.json key: cord-273614-qmp2tqtb authors: Tahir, Faryal; Bin Arif, Taha; Ahmed, Jawad; Malik, Farheen; Khalid, Muhammad title: Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): A Comprehensive Review date: 2020-05-08 journal: Cureus DOI: 10.7759/cureus.8021 sha: doc_id: 273614 cord_uid: qmp2tqtb file: cache/cord-274184-hm516x6p.json key: cord-274184-hm516x6p authors: Elli, Luca; Rimondi, Alessandro; Scaramella, Lucia; Topa, Matilde; Vecchi, Maurizio; Mangioni, Davide; Gori, Andrea; Penagini, Roberto title: Endoscopy during the Covid-19 outbreak: experience and recommendations from a single center in a high-incidence scenario date: 2020-04-27 journal: Dig Liver Dis DOI: 10.1016/j.dld.2020.04.018 sha: doc_id: 274184 cord_uid: hm516x6p file: cache/cord-273913-xem3alih.json key: cord-273913-xem3alih authors: Marraha, Farah; Al Faker, Ibtissam; Gallouj, Salim title: A Review of the Dermatological Manifestations of Coronavirus Disease 2019 (COVID-19) date: 2020-08-11 journal: Dermatol Res Pract DOI: 10.1155/2020/9360476 sha: doc_id: 273913 cord_uid: xem3alih file: cache/cord-273317-2e3vmdx4.json key: cord-273317-2e3vmdx4 authors: Shekhar, Rahul; Sheikh, Abu Baker; Suriya, Sajid S.; Upadhyay, Shubra; Zafar, Atif title: Neurological Complications Among Native Americans with COVID-19: Our Experience at a Tertiary Care Academic Hospital in the U.S. date: 2020-08-24 journal: J Stroke Cerebrovasc Dis DOI: 10.1016/j.jstrokecerebrovasdis.2020.105260 sha: doc_id: 273317 cord_uid: 2e3vmdx4 file: cache/cord-273758-hhd8xnve.json key: cord-273758-hhd8xnve authors: Ciardullo, S.; Zerbini, F.; Perra, S.; Muraca, E.; Cannistraci, R.; Lauriola, M.; Grosso, P.; Lattuada, G.; Ippoliti, G.; Mortara, A.; Manzoni, G.; Perseghin, G. title: Impact of diabetes on COVID-19-related in-hospital mortality: a retrospective study from Northern Italy date: 2020-08-10 journal: J Endocrinol Invest DOI: 10.1007/s40618-020-01382-7 sha: doc_id: 273758 cord_uid: hhd8xnve file: cache/cord-274250-95yzt1gj.json key: cord-274250-95yzt1gj authors: Mortaz, Esmaeil; Malkmohammad, Majid; Jamaati, Hamidreza; Naghan, Parisa Adimi; Hashemian, Seyed MohamadReza; Tabarsi, Payam; Varahram, Maohammad; Zaheri, Hamidreza; Chousein, Efsun Gonca Uğur; Folkerts, Gert; Adcock, Ian M. title: Silent hypoxia: higher NO in red blood cells of COVID-19 patients date: 2020-10-16 journal: BMC Pulm Med DOI: 10.1186/s12890-020-01310-8 sha: doc_id: 274250 cord_uid: 95yzt1gj file: cache/cord-274542-fpzk5k79.json key: cord-274542-fpzk5k79 authors: Patti, Giuseppe; Lio, Veronica; Cavallari, Ilaria; Gragnano, Felice; Riva, Letizia; Calabrò, Paolo; Di Pasquale, Giuseppe; Pengo, Vittorio; Rubboli, Andrea title: Questions and Answers on Practical Thrombotic Issues in SARS-CoV-2 Infection: A Guidance Document from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology date: 2020-11-03 journal: Am J Cardiovasc Drugs DOI: 10.1007/s40256-020-00446-6 sha: doc_id: 274542 cord_uid: fpzk5k79 file: cache/cord-274008-p3st70u3.json key: cord-274008-p3st70u3 authors: Mann, E. R.; Menon, M.; Knight, S. B.; Konkel, J. E.; Jagger, C.; Shaw, T. N.; Krishnan, S.; Rattray, M.; Ustianowski, A.; Bakerly, N. D.; Dark, P.; Lord, G.; Simpson, A.; Felton, T.; Ho, L.-P.; NIHR Respiratory TRC,; Feldmann, M.; CIRCO,; Grainger, J.; Hussell, T. title: Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis date: 2020-06-16 journal: nan DOI: 10.1101/2020.06.13.20127605 sha: doc_id: 274008 cord_uid: p3st70u3 file: cache/cord-274481-k1dp1ilv.json key: cord-274481-k1dp1ilv authors: Falavigna, Maicon; Colpani, Verônica; Stein, Cinara; Azevedo, Luciano Cesar Pontes; Bagattini, Angela Maria; de Brito, Gabriela Vilela; Chatkin, José Miguel; Cimerman, Sergio; Corradi, Mirian de Freitas Dal Ben; da Cunha, Clovis Arns; de Medeiros, Flávia Cordeiro; de Oliveira Junior, Haliton Alves; Fritscher, Leandro Genehr; Gazzana, Marcelo Basso; Gräf, Débora Dalmas; Marra, Lays Pires; Matuoka, Jessica Yumi; Nunes, Michelle Silva; Pachito, Daniela Vianna; Pagano, Cássia Garcia Moraes; Parreira, Patrícia do Carmo Silva; Riera, Rachel; Silva Júnior, Amilton; Tavares, Bruno de Melo; Zavascki, Alexandre Prehn; Rosa, Regis Goulart; Dal-Pizzol, Felipe title: Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology date: 2020 journal: Rev Bras Ter Intensiva DOI: 10.5935/0103-507x.20200039 sha: doc_id: 274481 cord_uid: k1dp1ilv file: cache/cord-273945-b1lekw47.json key: cord-273945-b1lekw47 authors: Bongiovanni, Alberto; Mercatali, Laura; Fausti, Valentina; Ibrahim, Toni title: Comment on ‘Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey” by Alice Indini et al. date: 2020-05-16 journal: Eur J Cancer DOI: 10.1016/j.ejca.2020.04.047 sha: doc_id: 273945 cord_uid: b1lekw47 file: cache/cord-274494-heu6rmbt.json key: cord-274494-heu6rmbt authors: Pablos, Jose L; Abasolo, Lydia; Alvaro-Gracia, Jose M; Blanco, Francisco J; Blanco, Ricardo; Castrejón, Isabel; Fernandez-Fernandez, David; Fernandez-Gutierrez, Benjamín; Galindo-Izquierdo, María; Gonzalez-Gay, Miguel A; Manrique-Arija, Sara; Mena Vázquez, Natalia; Mera Varela, Antonio; Retuerto, Miriam; Seijas-Lopez, Alvaro title: Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases date: 2020-06-12 journal: Ann Rheum Dis DOI: 10.1136/annrheumdis-2020-217763 sha: doc_id: 274494 cord_uid: heu6rmbt file: cache/cord-274666-0d8oz51l.json key: cord-274666-0d8oz51l authors: Han, Yi; Zhang, Haidong; Mu, Sucheng; Wei, Wei; Jin, Chaoyuan; Tong, Chaoyang; Song, Zhenju; Zha, Yunfei; Xue, Yuan; Gu, Guorong title: Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study date: 2020-06-24 journal: Aging (Albany NY) DOI: 10.18632/aging.103372 sha: doc_id: 274666 cord_uid: 0d8oz51l file: cache/cord-274632-d9z0m2l8.json key: cord-274632-d9z0m2l8 authors: Chenna, Avantika; Konala, Venu Madhav; Gayam, Vijay; Naramala, Srikanth; Adapa, Sreedhar title: Coronavirus Disease 2019 (COVID-19) in a Renal Transplant Patient date: 2020-05-09 journal: Cureus DOI: 10.7759/cureus.8038 sha: doc_id: 274632 cord_uid: d9z0m2l8 file: cache/cord-274245-pgfqkwqg.json key: cord-274245-pgfqkwqg authors: Rali, Aniket S; Trevino, Sergio; Yang, Edward; Herlihy, James P; Diaz-Gomez, Jose title: Cardiopulmonary Ultrasonography for Severe Coronavirus Disease 2019 Patients in Prone Position date: 2020-05-14 journal: Card Fail Rev DOI: 10.15420/cfr.2020.12 sha: doc_id: 274245 cord_uid: pgfqkwqg file: cache/cord-274557-2071770h.json key: cord-274557-2071770h authors: Späth, Peter J.; Granata, Guido; La Marra, Fabiola; Kuijpers, Taco W.; Quinti, Isabella title: On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events date: 2015-02-05 journal: Front Immunol DOI: 10.3389/fimmu.2015.00011 sha: doc_id: 274557 cord_uid: 2071770h file: cache/cord-274331-0i2opmcn.json key: cord-274331-0i2opmcn authors: Wang, Catherine J.; Truong, Allison K. title: COVID‐19 infection on IL‐23 inhibition date: 2020-07-14 journal: Dermatol Ther DOI: 10.1111/dth.13893 sha: doc_id: 274331 cord_uid: 0i2opmcn file: cache/cord-273996-z5vlw6nm.json key: cord-273996-z5vlw6nm authors: Di Dalmazi, Guido; Maltoni, Giulio; Bongiorno, Claudio; Tucci, Lorenzo; Di Natale, Valeria; Moscatiello, Simona; Laffi, Gilberto; Pession, Andrea; Zucchini, Stefano; Pagotto, Uberto title: Comparison of the effects of lockdown due to COVID-19 on glucose patterns among children, adolescents, and adults with type 1 diabetes: CGM study date: 2020-10-28 journal: BMJ Open Diabetes Res Care DOI: 10.1136/bmjdrc-2020-001664 sha: doc_id: 273996 cord_uid: z5vlw6nm file: cache/cord-274782-yymo9i6r.json key: cord-274782-yymo9i6r authors: Şahbat, Yavuz; Buyuktopcu, Omer; Topkar, Osman Mert; Erol, Bulent title: Management of orthopedic oncology patients during coronavirus pandemic date: 2020-07-02 journal: J Surg Oncol DOI: 10.1002/jso.26092 sha: doc_id: 274782 cord_uid: yymo9i6r file: cache/cord-274563-jimw6skv.json key: cord-274563-jimw6skv authors: Fiumara, Agata; Lanzafame, Giuseppina; Arena, Alessia; Sapuppo, Annamaria; Raudino, Federica; Praticò, Andrea; Pavone, Piero; Barone, Rita title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 journal: J Clin Med DOI: 10.3390/jcm9092716 sha: doc_id: 274563 cord_uid: jimw6skv file: cache/cord-274556-531jlpwr.json key: cord-274556-531jlpwr authors: Li, Wenrui; Chen, Xueming; Feng, Hai title: Impact of COVID-19 on Peripheral Arterial Disease Treatment date: 2020-06-02 journal: Ann Vasc Surg DOI: 10.1016/j.avsg.2020.05.045 sha: doc_id: 274556 cord_uid: 531jlpwr file: cache/cord-274282-hvx5m2bx.json key: cord-274282-hvx5m2bx authors: Liu, Yang; Mao, Bei; Liang, Shuo; Yang, Jia-wei; Lu, Hai-wen; Chai, Yan-hua; Wang, Lan; Zhang, Li; Li, Qiu-hong; Zhao, Lan; He, Yan; Gu, Xiao-long; Ji, Xiao-bin; Li, Li; Jie, Zhi-jun; Li, Qiang; Li, Xiang-yang; Lu, Hong-zhou; Zhang, Wen-hong; Song, Yuan-lin; Qu, Jie-ming; Xu, Jin-fu title: Association between ages and clinical characteristics and outcomes of coronavirus disease 2019 date: 2020-04-27 journal: Eur Respir J DOI: 10.1183/13993003.01112-2020 sha: doc_id: 274282 cord_uid: hvx5m2bx file: cache/cord-274121-3w6kc0c9.json key: cord-274121-3w6kc0c9 authors: Ramiro, Sofia; Mostard, Rémy L M; Magro-Checa, César; van Dongen, Christel M P; Dormans, Tom; Buijs, Jacqueline; Gronenschild, Michiel; de Kruif, Martijn D; van Haren, Eric H J; van Kraaij, Tom; Leers, Mathie P G; Peeters, Ralph; Wong, Dennis R; Landewé, Robert B M title: Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date: 2020-07-20 journal: Ann Rheum Dis DOI: 10.1136/annrheumdis-2020-218479 sha: doc_id: 274121 cord_uid: 3w6kc0c9 file: cache/cord-274779-0emfl1e5.json key: cord-274779-0emfl1e5 authors: Andrews, Jinsy A.; Berry, James D.; Baloh, Robert H.; Carberry, Nathan; Cudkowicz, Merit E.; Dedi, Brixhilda; Glass, Jonathan; Maragakis, Nicholas J.; Miller, Timothy M.; Paganoni, Sabrina; Rothstein, Jeffrey D.; Shefner, Jeremy M.; Simmons, Zachary; Weiss, Michael D.; Bedlack, Richard S. title: Amyotrophic lateral sclerosis care and research in the United States during the COVID‐19 pandemic: Challenges and opportunities date: 2020-06-05 journal: Muscle Nerve DOI: 10.1002/mus.26989 sha: doc_id: 274779 cord_uid: 0emfl1e5 file: cache/cord-275041-fcdwitxy.json key: cord-275041-fcdwitxy authors: Ayerbe, Luis; Risco-Risco, Carlos; Ayis, Salma title: The association of treatment with hydroxychloroquine and hospital mortality in COVID-19 patients date: 2020-09-30 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02505-x sha: doc_id: 275041 cord_uid: fcdwitxy file: cache/cord-274355-6hiutrct.json key: cord-274355-6hiutrct authors: Satheesan, Manoj Kumar; Mui, Kwok Wai; Wong, Ling Tim title: A numerical study of ventilation strategies for infection risk mitigation in general inpatient wards date: 2020-02-22 journal: Build Simul DOI: 10.1007/s12273-020-0623-4 sha: doc_id: 274355 cord_uid: 6hiutrct file: cache/cord-274324-obhrbxu4.json key: cord-274324-obhrbxu4 authors: Tian, Wenjie; Jiang, Wanlin; Yao, Jie; Nicholson, Christopher J.; Li, Rebecca H.; Sigurslid, Haakon H.; Wooster, Luke; Rotter, Jerome I.; Guo, Xiuqing; Malhotra, Rajeev title: Predictors of mortality in hospitalized COVID‐19 patients: A systematic review and meta‐analysis date: 2020-05-22 journal: J Med Virol DOI: 10.1002/jmv.26050 sha: doc_id: 274324 cord_uid: obhrbxu4 file: cache/cord-274934-s8xppipe.json key: cord-274934-s8xppipe authors: Gebbia, Vittorio; Piazza, Dario; Valerio, Maria Rosaria; Borsellino, Nicolò; Firenze, Alberto title: Patients With Cancer and COVID-19: A WhatsApp Messenger-Based Survey of Patients’ Queries, Needs, Fears, and Actions Taken date: 2020-05-15 journal: JCO Glob Oncol DOI: 10.1200/go.20.00118 sha: doc_id: 274934 cord_uid: s8xppipe file: cache/cord-274802-7ioiwsd8.json key: cord-274802-7ioiwsd8 authors: Varghese, Praveen Mathews; Tsolaki, Anthony G.; Yasmin, Hadida; Shastri, Abhishek; Ferluga, Janez; Vatish, Manu; Madan, Taruna; Kishore, Uday title: Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies date: 2020-08-19 journal: Immunobiology DOI: 10.1016/j.imbio.2020.152008 sha: doc_id: 274802 cord_uid: 7ioiwsd8 file: cache/cord-274860-7ec2jcoq.json key: cord-274860-7ec2jcoq authors: Salazar, Eric; Christensen, Paul A.; Graviss, Edward A.; Nguyen, Duc T.; Castillo, Brian; Chen, Jian; Lopez, Bevin Valdez; Eagar, Todd N.; Yi, Xin; Zhao, Picheng; Rogers, John; Shehabeldin, Ahmed; Joseph, David; Masud, Faisal; Leveque, Christopher; Olsen, Randall J.; Bernard, David W.; Gollihar, Jimmy; Musser, James M. title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date: 2020-11-04 journal: Am J Pathol DOI: 10.1016/j.ajpath.2020.10.008 sha: doc_id: 274860 cord_uid: 7ec2jcoq file: cache/cord-275110-safr9z37.json key: cord-275110-safr9z37 authors: Alexander, Paul Elias; Debono, Victoria Borg; Mammen, Manoj J.; Iorio, Alfonso; Aryal, Komal; Deng, Dianna; Brocard, Eva; Alhazzani, Waleed title: COVID-19 research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine date: 2020-04-21 journal: J Clin Epidemiol DOI: 10.1016/j.jclinepi.2020.04.016 sha: doc_id: 275110 cord_uid: safr9z37 file: cache/cord-274871-jlquvz51.json key: cord-274871-jlquvz51 authors: Nori, Priya; Cowman, Kelsie; Chen, Victor; Bartash, Rachel; Szymczak, Wendy; Madaline, Theresa; Punjabi Katiyar, Chitra; Jain, Ruchika; Aldrich, Margaret; Weston, Gregory; Gialanella, Philip; Corpuz, Marilou; Gendlina, Inessa; Guo, Yi title: Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge date: 2020-07-24 journal: Infection control and hospital epidemiology DOI: 10.1017/ice.2020.368 sha: doc_id: 274871 cord_uid: jlquvz51 file: cache/cord-275185-9br8lwma.json key: cord-275185-9br8lwma authors: Zeng, Hao; Wang, Dongfang; Nie, Jingmin; Liang, Haoyu; Gu, Jiang; Zhao, Anne; Xu, Lixin; Lang, Chunhui; Cui, Xiaoping; Guo, Xiaolan; Zhou, Changlong; Li, Haibo; Guo, Bin; Zhang, Jinyong; Wang, Qiang; Fang, Li; Liu, Wen; Huang, Yishan; Mao, Wei; Chen, Yaokai; Zou, Quanming title: The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series date: 2020-10-06 journal: Signal Transduct Target Ther DOI: 10.1038/s41392-020-00329-x sha: doc_id: 275185 cord_uid: 9br8lwma file: cache/cord-275257-upj8mvzn.json key: cord-275257-upj8mvzn authors: Hwang, E. Shelley; Balch, Charles M.; Balch, Glen C.; Feldman, Sheldon M.; Golshan, Mehra; Grobmyer, Stephen R.; Libutti, Steven K.; Margenthaler, Julie A.; Sasidhar, Madhu; Turaga, Kiran K.; Wong, Sandra L.; McMasters, Kelly M.; Tanabe, Kenneth K. title: Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change date: 2020-06-14 journal: Ann Surg Oncol DOI: 10.1245/s10434-020-08673-6 sha: doc_id: 275257 cord_uid: upj8mvzn file: cache/cord-275260-xuhxqkyj.json key: cord-275260-xuhxqkyj authors: Sardu, Celestino; D’Onofrio, Nunzia; Balestrieri, Maria Luisa; Barbieri, Michelangela; Rizzo, Maria Rosaria; Messina, Vincenzo; Maggi, Paolo; Coppola, Nicola; Paolisso, Giuseppe; Marfella, Raffaele title: Hyperglycaemia on admission to hospital and COVID-19 date: 2020-07-06 journal: Diabetologia DOI: 10.1007/s00125-020-05216-2 sha: doc_id: 275260 cord_uid: xuhxqkyj file: cache/cord-275518-p03sl946.json key: cord-275518-p03sl946 authors: Borsa, Stefano; Bertani, Giulio; Gay, Lorenzo; Pirola, Elena; Riva, Marco; Caroli, Manuela title: Call of duty: neuro-oncology outpatient management during the COVID-19 pandemic in Milan, ITALY date: 2020-07-10 journal: Neuro Oncol DOI: 10.1093/neuonc/noaa164 sha: doc_id: 275518 cord_uid: p03sl946 file: cache/cord-275266-e6omvo5x.json key: cord-275266-e6omvo5x authors: Kort, Nanne P; Zagra, Luigi; Barrena, Enrique Gomez; Tandogan, Reha N; Thaler, Martin; Berstock, James R; Karachalios, Theofilos title: Resuming hip and knee arthroplasty after COVID-19: ethical implications for well-being, safety and the economy date: 2020-07-07 journal: Hip Int DOI: 10.1177/1120700020941232 sha: doc_id: 275266 cord_uid: e6omvo5x file: cache/cord-275004-qzg03dvg.json key: cord-275004-qzg03dvg authors: Veras, Flavio Protasio; Pontelli, Marjorie Cornejo; Silva, Camila Meirelles; Toller-Kawahisa, Juliana E.; de Lima, Mikhael; Nascimento, Daniele Carvalho; Schneider, Ayda Henriques; Caetité, Diego; Tavares, Lucas Alves; Paiva, Isadora M.; Rosales, Roberta; Colón, David; Martins, Ronaldo; Castro, Italo Araujo; Almeida, Glaucia M.; Lopes, Maria Isabel Fernandes; Benatti, Maíra Nilson; Bonjorno, Letícia Pastorelli; Giannini, Marcela Cavichioli; Luppino-Assad, Rodrigo; Almeida, Sérgio Luna; Vilar, Fernando; Santana, Rodrigo; Bollela, Valdes R.; Auxiliadora-Martins, Maria; Borges, Marcos; Miranda, Carlos Henrique; Pazin-Filho, Antônio; da Silva, Luis Lamberti P.; Cunha, Larissa; Zamboni, Dario S.; Dal-Pizzol, Felipe; Leiria, Luiz O.; Siyuan, Li; Batah, Sabrina; Fabro, Alexandre; Mauad, Thais; Dolhnikoff, Marisa; Duarte-Neto, Amaro; Saldiva, Paulo; Cunha, Thiago Mattar; Alves-Filho, José Carlos; Arruda, Eurico; Louzada-Junior, Paulo; Oliveira, Renê Donizeti; Cunha, Fernando Queiroz title: SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology date: 2020-09-14 journal: J Exp Med DOI: 10.1084/jem.20201129 sha: doc_id: 275004 cord_uid: qzg03dvg file: cache/cord-275214-mqvw0219.json key: cord-275214-mqvw0219 authors: Burlacu, Alexandru; Artene, Bogdan; Crisan-Dabija, Radu; Popa, Iolanda Valentina; Covic, Adrian title: Is Thrombophilic Genetic Profile Responsible for an Acute Ischemic Stroke in a COVID-19 Male Patient? date: 2020-10-15 journal: Clin Appl Thromb Hemost DOI: 10.1177/1076029620967107 sha: doc_id: 275214 cord_uid: mqvw0219 file: cache/cord-275477-blu6wjhu.json key: cord-275477-blu6wjhu authors: Trimaille, Antonin; Bonnet, Guillaume title: COVID-19 et pathologie thromboembolique veineuse date: 2020-09-29 journal: Ann Cardiol Angeiol (Paris) DOI: 10.1016/j.ancard.2020.09.027 sha: doc_id: 275477 cord_uid: blu6wjhu file: cache/cord-276249-9opsg7p2.json key: cord-276249-9opsg7p2 authors: Roberto, Katrina T.; Espiritu, Adrian I.; Fernandez, Marc Laurence L.; Gutierrez, Josephine C. title: Electroencephalographic findings in COVID-19 patients: A systematic review date: 2020-09-15 journal: Seizure DOI: 10.1016/j.seizure.2020.09.007 sha: doc_id: 276249 cord_uid: 9opsg7p2 file: cache/cord-275154-vwnpred5.json key: cord-275154-vwnpred5 authors: Bermejo-Martin, Jesus F; Ortiz de Lejarazu, Raul; Pumarola, Tomas; Rello, Jordi; Almansa, Raquel; Ramírez, Paula; Martin-Loeches, Ignacio; Varillas, David; Gallegos, Maria C; Serón, Carlos; Micheloud, Dariela; Gomez, Jose Manuel; Tenorio-Abreu, Alberto; Ramos, María J; Molina, M Lourdes; Huidobro, Samantha; Sanchez, Elia; Gordón, Mónica; Fernández, Victoria; del Castillo, Alberto; Marcos, Ma Ángeles; Villanueva, Beatriz; López, Carlos Javier; Rodríguez-Domínguez, Mario; Galan, Juan-Carlos; Cantón, Rafael; Lietor, Aurora; Rojo, Silvia; Eiros, Jose M; Hinojosa, Carmen; Gonzalez, Isabel; Torner, Nuria; Banner, David; Leon, Alberto; Cuesta, Pablo; Rowe, Thomas; Kelvin, David J title: Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza date: 2009-12-11 journal: Crit Care DOI: 10.1186/cc8208 sha: doc_id: 275154 cord_uid: vwnpred5 file: cache/cord-275349-b35pt3mo.json key: cord-275349-b35pt3mo authors: Lenz, Heinz-Josef; Richardson, Peter; Stebbing, Justin title: The Emergence of Baricitinib: A Story of Tortoises Versus Hares date: 2020-07-06 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa940 sha: doc_id: 275349 cord_uid: b35pt3mo file: cache/cord-275340-q8d7rvnj.json key: cord-275340-q8d7rvnj authors: Sun, JingKang; Chen, YuTing; Fan, XiuDe; Wang, XiaoYun; Han, QunYing; Liu, ZhengWen title: Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 date: 2020-06-21 journal: Postgraduate medicine DOI: 10.1080/00325481.2020.1778982 sha: doc_id: 275340 cord_uid: q8d7rvnj file: cache/cord-276132-tv5y1eqc.json key: cord-276132-tv5y1eqc authors: Ray, Upasana; Aziz, Faisal; Shankar, Abhishek; Biswas, Aalekhya Sharma; Chakraborty, Abhijit title: COVID-19: The Impact in Oncology Care date: 2020-10-23 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00592-7 sha: doc_id: 276132 cord_uid: tv5y1eqc file: cache/cord-276241-4g6pa7kz.json key: cord-276241-4g6pa7kz authors: Yurttaş, Berna; Oztas, Mert; Tunc, Ali; Balkan, İlker İnanç; Tabak, Omer Fehmi; Hamuryudan, Vedat; Seyahi, Emire title: Characteristics and outcomes of Behçet’s syndrome patients with Coronavirus Disease 2019: a case series of 10 patients date: 2020-07-09 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02427-8 sha: doc_id: 276241 cord_uid: 4g6pa7kz file: cache/cord-275440-fl4dsu7d.json key: cord-275440-fl4dsu7d authors: Turnidge, John title: Responsible Prescribing for Upper Respiratory Tract Infections date: 2012-10-10 journal: Drugs DOI: 10.2165/00003495-200161140-00004 sha: doc_id: 275440 cord_uid: fl4dsu7d file: cache/cord-276264-wgzh3f5m.json key: cord-276264-wgzh3f5m authors: Navlakha, S.; Morjaria, S.; Perez-Johnston, R.; Zhang, A.; Taur, Y. title: Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning date: 2020-08-25 journal: nan DOI: 10.1101/2020.08.23.20179838 sha: doc_id: 276264 cord_uid: wgzh3f5m file: cache/cord-276288-upv2o8f6.json key: cord-276288-upv2o8f6 authors: Prior, Sarah Jane; Mather, Carey; Ford, Karen; Bywaters, Danielle; Campbell, Steven title: Person-centred data collection methods to embed the authentic voice of people who experience health challenges date: 2020-07-21 journal: BMJ Open Qual DOI: 10.1136/bmjoq-2020-000912 sha: doc_id: 276288 cord_uid: upv2o8f6 file: cache/cord-275272-qdg8sqpy.json key: cord-275272-qdg8sqpy authors: Soares-Júnior, José Maria; Sorpreso, Isabel C.E.; Motta, Eduardo Vieira; Utiyama, Edivaldo Massazo; Baracat, Edmund Chada title: Gynecology and women’s health care during the COVID-19 pandemic: Patient safety in surgery and prevention date: 2020-06-16 journal: Clinics (Sao Paulo) DOI: 10.6061/clinics/2020/e2063 sha: doc_id: 275272 cord_uid: qdg8sqpy file: cache/cord-276090-n8c2jpr6.json key: cord-276090-n8c2jpr6 authors: Patel, Hiren N.; Syed, Asma; Lobel, Jeffrey S.; Galler, Robert; Georges, Joseph; Carmody, Margaret; Puumala, Micheal title: Cerebellar Infarction Requiring Surgical Decompression in patient with COVID 19 Pathological Analysis, Brief Review date: 2020-07-29 journal: Interdiscip Neurosurg DOI: 10.1016/j.inat.2020.100850 sha: doc_id: 276090 cord_uid: n8c2jpr6 file: cache/cord-276267-77903fld.json key: cord-276267-77903fld authors: Al‐Ani, Aysha H.; Prentice, Ralley E.; Rentsch, Clarissa A.; Johnson, Doug; Ardalan, Zaid; Heerasing, Neel; Garg, Mayur; Campbell, Sian; Sasadeusz, Joe; Macrae, Finlay A.; Ng, Siew C.; Rubin, David T.; Christensen, Britt title: Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient date: 2020-05-26 journal: Aliment Pharmacol Ther DOI: 10.1111/apt.15779 sha: doc_id: 276267 cord_uid: 77903fld file: cache/cord-275979-cx2h5bsw.json key: cord-275979-cx2h5bsw authors: Scutelnic, Adrian; Heldner, Mirjam R. title: Vascular Events, Vascular Disease and Vascular Risk Factors—Strongly Intertwined with COVID-19 date: 2020-10-08 journal: Curr Treat Options Neurol DOI: 10.1007/s11940-020-00648-y sha: doc_id: 275979 cord_uid: cx2h5bsw file: cache/cord-276303-lgywz9ea.json key: cord-276303-lgywz9ea authors: Rello, Jordi; Waterer, Grant W.; Bourdiol, Alexandre; Roquilly, Antoine title: COVID-19, steroids and other immunomodulators: The jigsaw is not complete date: 2020-10-25 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.10.011 sha: doc_id: 276303 cord_uid: lgywz9ea file: cache/cord-276359-syr9av09.json key: cord-276359-syr9av09 authors: Piva, Simone; Filippini, Matteo; Turla, Fabio; Cattaneo, Sergio; Margola, Alessio; De Fulviis, Silvia; Nardiello, Ida; Beretta, Alessandra; Ferrari, Laura; Trotta, Raffaella; Erbici, Gloria; Focà, Emanuele; Castelli, Francesco; Rasulo, Frank; Lanspa, Michael J.; Latronico, Nicola title: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy date: 2020-04-14 journal: J Crit Care DOI: 10.1016/j.jcrc.2020.04.004 sha: doc_id: 276359 cord_uid: syr9av09 file: cache/cord-276234-2nkeq4ud.json key: cord-276234-2nkeq4ud authors: Siedlecki, Jakob; Brantl, Victor; Schworm, Benedikt; Mayer, Wolfgang Johann; Gerhardt, Maximilian; Michalakis, Stylianos; Kreutzer, Thomas; Priglinger, Siegfried title: COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic date: 2020-05-06 journal: Klin Monbl Augenheilkd DOI: 10.1055/a-1164-9381 sha: doc_id: 276234 cord_uid: 2nkeq4ud file: cache/cord-276524-th6eu11h.json key: cord-276524-th6eu11h authors: Atallah, Bassam; El Nekidy, Wasim; Mallah, Saad I.; Cherfan, Antoine; AbdelWareth, Laila; Mallat, Jihad; Hamed, Fadi title: Thrombotic events following tocilizumab therapy in critically ill COVID-19 patients: a Façade for prognostic markers date: 2020-09-09 journal: Thromb J DOI: 10.1186/s12959-020-00236-9 sha: doc_id: 276524 cord_uid: th6eu11h file: cache/cord-275506-3t5gf66c.json key: cord-275506-3t5gf66c authors: Agbuduwe, Charles; Basu, Supratik title: Hematolological Manifestations of COVID‐19: From Cytopenia to Coagulopathy date: 2020-07-14 journal: Eur J Haematol DOI: 10.1111/ejh.13491 sha: doc_id: 275506 cord_uid: 3t5gf66c file: cache/cord-275742-7jxt6diq.json key: cord-275742-7jxt6diq authors: Batarseh, Feras A.; Ghassib, Iya; Chong, Deri (Sondor); Su, Po-Hsuan title: Preventive healthcare policies in the US: solutions for disease management using Big Data Analytics date: 2020-06-23 journal: J Big Data DOI: 10.1186/s40537-020-00315-8 sha: doc_id: 275742 cord_uid: 7jxt6diq file: cache/cord-276405-yfvu83r9.json key: cord-276405-yfvu83r9 authors: Brat, Gabriel A.; Weber, Griffin M.; Gehlenborg, Nils; Avillach, Paul; Palmer, Nathan P.; Chiovato, Luca; Cimino, James; Waitman, Lemuel R.; Omenn, Gilbert S.; Malovini, Alberto; Moore, Jason H.; Beaulieu-Jones, Brett K.; Tibollo, Valentina; Murphy, Shawn N.; Yi, Sehi L’; Keller, Mark S.; Bellazzi, Riccardo; Hanauer, David A.; Serret-Larmande, Arnaud; Gutierrez-Sacristan, Alba; Holmes, John J.; Bell, Douglas S.; Mandl, Kenneth D.; Follett, Robert W.; Klann, Jeffrey G.; Murad, Douglas A.; Scudeller, Luigia; Bucalo, Mauro; Kirchoff, Katie; Craig, Jean; Obeid, Jihad; Jouhet, Vianney; Griffier, Romain; Cossin, Sebastien; Moal, Bertrand; Patel, Lav P.; Bellasi, Antonio; Prokosch, Hans U.; Kraska, Detlef; Sliz, Piotr; Tan, Amelia L. M.; Ngiam, Kee Yuan; Zambelli, Alberto; Mowery, Danielle L.; Schiver, Emily; Devkota, Batsal; Bradford, Robert L.; Daniar, Mohamad; Daniel, Christel; Benoit, Vincent; Bey, Romain; Paris, Nicolas; Serre, Patricia; Orlova, Nina; Dubiel, Julien; Hilka, Martin; Jannot, Anne Sophie; Breant, Stephane; Leblanc, Judith; Griffon, Nicolas; Burgun, Anita; Bernaux, Melodie; Sandrin, Arnaud; Salamanca, Elisa; Cormont, Sylvie; Ganslandt, Thomas; Gradinger, Tobias; Champ, Julien; Boeker, Martin; Martel, Patricia; Esteve, Loic; Gramfort, Alexandre; Grisel, Olivier; Leprovost, Damien; Moreau, Thomas; Varoquaux, Gael; Vie, Jill-Jênn; Wassermann, Demian; Mensch, Arthur; Caucheteux, Charlotte; Haverkamp, Christian; Lemaitre, Guillaume; Bosari, Silvano; Krantz, Ian D.; South, Andrew; Cai, Tianxi; Kohane, Isaac S. title: International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium date: 2020-08-19 journal: NPJ Digit Med DOI: 10.1038/s41746-020-00308-0 sha: doc_id: 276405 cord_uid: yfvu83r9 file: cache/cord-276343-sb3vd7fq.json key: cord-276343-sb3vd7fq authors: Humar, Atul; Doucette, Karen; Kumar, Deepali; Pang, Xiao-Li; Lien, Dale; Jackson, Kathy; Preiksaitis, Jutta title: Assessment of Adenovirus Infection in Adult Lung Transplant Recipients Using Molecular Surveillance date: 2006-12-31 journal: The Journal of Heart and Lung Transplantation DOI: 10.1016/j.healun.2006.09.015 sha: doc_id: 276343 cord_uid: sb3vd7fq file: cache/cord-276438-nynri6my.json key: cord-276438-nynri6my authors: Lu, Jiade J. title: Experience of a Radiation Oncology Center Operating During the COVID-19 Outbreak date: 2020-04-10 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.04.003 sha: doc_id: 276438 cord_uid: nynri6my file: cache/cord-275913-85u6v3ib.json key: cord-275913-85u6v3ib authors: Bauernschmitt, Robert; Gabriel, Philip; Gottardi, Roman; Sodian, Ralf title: Valve-in-valve transcatheter aortic valve replacement in a young patient with a suspected COVID-19 infection: a surgical dilemma in the era of the COVID-19 pandemic date: 2020-06-08 journal: Eur J Cardiothorac Surg DOI: 10.1093/ejcts/ezaa193 sha: doc_id: 275913 cord_uid: 85u6v3ib file: cache/cord-276495-q22jnkn2.json key: cord-276495-q22jnkn2 authors: Belizário, José Ernesto title: Trained innate immunity, COVID-19 therapeutic dilemma, and fake science date: 2020-07-06 journal: Clinics (Sao Paulo) DOI: 10.6061/clinics/2020/e2124 sha: doc_id: 276495 cord_uid: q22jnkn2 file: cache/cord-276635-0ciy732e.json key: cord-276635-0ciy732e authors: Nijjer, Sukhjinder Singh; Petraco, Ricardo; Sen, Sayan title: Optimal management of acute coronary syndromes in the era of COVID-19 date: 2020-09-02 journal: Heart DOI: 10.1136/heartjnl-2020-317143 sha: doc_id: 276635 cord_uid: 0ciy732e file: cache/cord-276327-wyevh4xv.json key: cord-276327-wyevh4xv authors: Sheng, Calvin C; Sahoo, Debasis; Dugar, Siddharth; Prada, Robier Aguillon; Wang, Tom Kai Ming; Abou Hassan, Ossama K; Brennan, Danielle; Culver, Daniel A; Rajendram, Prabalini; Duggal, Abhijit; Lincoff, A Michael; Nissen, Steven E; Menon, Venu; Cremer, Paul C title: Canakinumab to reduce deterioration of cardiac and respiratory function in SARS‐CoV‐2 associated myocardial injury with heightened inflammation (canakinumab in Covid‐19 cardiac injury: The three C study) date: 2020-08-24 journal: Clin Cardiol DOI: 10.1002/clc.23451 sha: doc_id: 276327 cord_uid: wyevh4xv file: cache/cord-276676-lgt0rzob.json key: cord-276676-lgt0rzob authors: Moka, Eleni; Paladini, Antonella; Rekatsina, Martina; Urits, Ivan; Viswanath, Omar; Kaye, Alan D.; Yeam, Cheng Teng; Varrassi, Giustino title: Best Practice in Cardiac Anesthesia during the COVID-19 Pandemic: Practical Recommendations date: 2020-07-03 journal: Best Pract Res Clin Anaesthesiol DOI: 10.1016/j.bpa.2020.06.008 sha: doc_id: 276676 cord_uid: lgt0rzob file: cache/cord-276856-88d3vzbs.json key: cord-276856-88d3vzbs authors: Petersen, Lonnie G.; Friend, James; Merritt, Sidney title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients date: 2020-06-18 journal: Crit Care DOI: 10.1186/s13054-020-03041-y sha: doc_id: 276856 cord_uid: 88d3vzbs file: cache/cord-276621-9exp8e7h.json key: cord-276621-9exp8e7h authors: Jacobs, Jeremy M.; Marcus, Esther-Lee; Stessman, Jochanan title: Prolonged Mechanical Ventilation: Symptomatology, Well-Being, and Attitudes to Life date: 2020-09-06 journal: J Am Med Dir Assoc DOI: 10.1016/j.jamda.2020.07.037 sha: doc_id: 276621 cord_uid: 9exp8e7h file: cache/cord-276927-rxudwp2v.json key: cord-276927-rxudwp2v authors: Barbas, Carmen Sílvia Valente; Matos, Gustavo Faissol Janot; Amato, Marcelo Britto Passos; Carvalho, Carlos Roberto Ribeiro title: Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome date: 2012-08-23 journal: Crit Care Res Pract DOI: 10.1155/2012/952168 sha: doc_id: 276927 cord_uid: rxudwp2v file: cache/cord-276782-3fpmatkb.json key: cord-276782-3fpmatkb authors: Garbey, M.; Joerger, G.; Furr, S.; Fikfak, V. title: A Model of Workflow in the Hospital During a Pandemic to Assist Management date: 2020-05-02 journal: nan DOI: 10.1101/2020.04.28.20083154 sha: doc_id: 276782 cord_uid: 3fpmatkb file: cache/cord-276784-8lmg97zc.json key: cord-276784-8lmg97zc authors: Boziki, Marina Kleopatra; Mentis, Alexios-Fotios A.; Shumilina, Maria; Makshakov, Gleb; Evdoshenko, Evgeniy; Grigoriadis, Nikolaos title: COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated Demyelination date: 2020-06-04 journal: Brain Sci DOI: 10.3390/brainsci10060345 sha: doc_id: 276784 cord_uid: 8lmg97zc file: cache/cord-276834-20lcihf4.json key: cord-276834-20lcihf4 authors: Idilman, Ilkay S.; Telli Dizman, Gulcin; Ardali Duzgun, Selin; Irmak, Ilim; Karcaaltincaba, Musturay; Inkaya, Ahmet Cagkan; Demirkazik, Figen; Durhan, Gamze; Gulsun Akpinar, Meltem; Ariyurek, Orhan Macit; Akpinar, Erhan; Rello, Jordi; Akova, Murat; Akata, Deniz title: Lung and kidney perfusion deficits diagnosed by dual-energy computed tomography in patients with COVID-19-related systemic microangiopathy date: 2020-08-29 journal: Eur Radiol DOI: 10.1007/s00330-020-07155-3 sha: doc_id: 276834 cord_uid: 20lcihf4 file: cache/cord-276592-dsilwfl1.json key: cord-276592-dsilwfl1 authors: Chou, Calvin L title: How COVID-19 Disrupts—and Enhances—My Clinical Work date: 2020-04-08 journal: J Patient Exp DOI: 10.1177/2374373520918739 sha: doc_id: 276592 cord_uid: dsilwfl1 file: cache/cord-277189-fe8ego7f.json key: cord-277189-fe8ego7f authors: Szabados, Bernadett; Abu-Ghanem, Yasmin; Grant, Michael; Choy, Julia; Bex, Axel; Powles, Thomas title: Clinical Characteristics and Outcome for Four SARS-CoV-2-infected Cancer Patients Treated with Immune Checkpoint Inhibitors date: 2020-05-26 journal: Eur Urol DOI: 10.1016/j.eururo.2020.05.024 sha: doc_id: 277189 cord_uid: fe8ego7f file: cache/cord-277096-zvb7n9wo.json key: cord-277096-zvb7n9wo authors: Bond, David A.; Dotson, Emily; Awan, Farrukh T.; Baiocchi, Robert A.; Blum, Kristie A.; Maddocks, Kami title: Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date: 2018-11-29 journal: Clin Lymphoma Myeloma Leuk DOI: 10.1016/j.clml.2018.11.020 sha: doc_id: 277096 cord_uid: zvb7n9wo file: cache/cord-277148-xzpuc22p.json key: cord-277148-xzpuc22p authors: Ammirati, Enrico; Veronese, Giacomo; Bottiroli, Maurizio; Wang, Dao Wen; Cipriani, Manlio; Garascia, Andrea; Pedrotti, Patrizia; Adler, Eric D.; Frigerio, Maria title: UPDATE ON ACUTE MYOCARDITIS date: 2020-06-01 journal: Trends Cardiovasc Med DOI: 10.1016/j.tcm.2020.05.008 sha: doc_id: 277148 cord_uid: xzpuc22p file: cache/cord-277260-7se220oz.json key: cord-277260-7se220oz authors: Gosain, Rohit; Abdou, Yara; Singh, Abhay; Rana, Navpreet; Puzanov, Igor; Ernstoff, Marc S. title: COVID-19 and Cancer: a Comprehensive Review date: 2020-05-08 journal: Curr Oncol Rep DOI: 10.1007/s11912-020-00934-7 sha: doc_id: 277260 cord_uid: 7se220oz file: cache/cord-277014-iz8jo44e.json key: cord-277014-iz8jo44e authors: Hu, Weihua; lv, Xinke; Li, Chang; Xu, Yang; Qi, Yiding; Zhang, Zhuheng; Li, Mingxuan; Cai, Feina; Liu, Dan; Yue, Jiang; Ye, Maoqing; Chen, Qijian; Shi, Kailei title: Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study date: 2020-10-16 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02515-9 sha: doc_id: 277014 cord_uid: iz8jo44e file: cache/cord-277328-9s8fwg1h.json key: cord-277328-9s8fwg1h authors: Zhuang, Yuandi; Lin, Liaoyi; Xu, Xunhua; Xia, Tianyi; Yu, Huili; Fu, Gangze; Yang, Yunjun; Wang, Meihao; Sun, Houzhang title: Dynamic changes on chest CT of COVID-19 patients with solitary pulmonary lesion in initial CT date: 2020-09-04 journal: Jpn J Radiol DOI: 10.1007/s11604-020-01037-w sha: doc_id: 277328 cord_uid: 9s8fwg1h file: cache/cord-277535-u283k70i.json key: cord-277535-u283k70i authors: Vaja, Rakesh; Rana, Meenal title: Drugs and the liver date: 2020-09-22 journal: nan DOI: 10.1016/j.mpaic.2020.07.001 sha: doc_id: 277535 cord_uid: u283k70i file: cache/cord-276641-40r4mitg.json key: cord-276641-40r4mitg authors: Elkhouly, Enas A; Salem, Radwa H; Haggag, Mahmoud title: Should cancer treatment be continued during the COVID-19 pandemic? A single Egyptian institution experience date: 2020-07-23 journal: Ecancermedicalscience DOI: 10.3332/ecancer.2020.1077 sha: doc_id: 276641 cord_uid: 40r4mitg file: cache/cord-277201-jzjxsetx.json key: cord-277201-jzjxsetx authors: Mazo, Jahinover; Singh, Sukhdev; Khan, Zohaib; Foster, Allison; Komarnitsky, Ecaterina; Nagaraj, Abhiram; Patel, Soham; Kikkeri, Vinaya title: More than Just Pneumonia: Acute Pulmonary Embolism in Two Middle-Aged Patients with COVID-19 date: 2020-07-30 journal: Case Rep Med DOI: 10.1155/2020/4812036 sha: doc_id: 277201 cord_uid: jzjxsetx file: cache/cord-277539-xt2nt11e.json key: cord-277539-xt2nt11e authors: Kochhar, Anuraj Singh; Bhasin, Ritasha; Kochhar, Gulsheen Kaur; Dadlani, Himanshu; Thakkar, Balvinder; Singh, Gurkeerat title: Dentistry during and after COVID-19 Pandemic: Pediatric Considerations date: 2020 journal: Int J Clin Pediatr Dent DOI: 10.5005/jp-journals-10005-1782 sha: doc_id: 277539 cord_uid: xt2nt11e file: cache/cord-277146-4a4vz36h.json key: cord-277146-4a4vz36h authors: Aggarwal, Mukul; Dass, Jasmita; Mahapatra, Manoranjan title: Hemostatic Abnormalities in COVID-19: An Update date: 2020-08-11 journal: Indian J Hematol Blood Transfus DOI: 10.1007/s12288-020-01328-2 sha: doc_id: 277146 cord_uid: 4a4vz36h file: cache/cord-277207-2my86ums.json key: cord-277207-2my86ums authors: Zhou, H.; Chen, W.; Li, Z.; Yang, B.; Zhou, Q.; Wang, P.; Zhu, J.; Chen, X.; Yang, P. title: Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19) date: 2020-04-15 journal: nan DOI: 10.1101/2020.04.11.20059170 sha: doc_id: 277207 cord_uid: 2my86ums file: cache/cord-277498-hdhq99k2.json key: cord-277498-hdhq99k2 authors: Chua, Melvin L.K.; Ma, Daniel J.; Anderson, Carryn M.; Karam, Sana D.; Margalit, Danielle N.; Kimple, Randall J. title: Follow-up and management of head and neck cancer patients during the 2019 novel coronavirus (SARS-CoV-2) disease pandemic date: 2020-05-15 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.04.031 sha: doc_id: 277498 cord_uid: hdhq99k2 file: cache/cord-277576-3dvt6uj7.json key: cord-277576-3dvt6uj7 authors: Demir, Erol; Uyar, Murathan; Parmaksiz, Ergun; Sinangil, Ayse; Yelken, Berna; Dirim, Ahmet Burak; Merhametsiz, Ozgur; Yadigar, Serap; Atan Ucar, Zuhal; Ucar, Ali Riza; Demir, Mehmet Emin; Mese, Meral; Akin, Emin Baris; Garayeva, Nurana; Safak, Seda; Oto, Ozgur Akin; Yazici, Halil; Turkmen, Aydin title: COVID‐19 in kidney transplant recipients: A multicenter experience in Istanbul date: 2020-07-13 journal: Transpl Infect Dis DOI: 10.1111/tid.13371 sha: doc_id: 277576 cord_uid: 3dvt6uj7 file: cache/cord-277700-nxm1jr0x.json key: cord-277700-nxm1jr0x authors: Chassagnon, Guillaume; Vakalopoulou, Maria; Battistella, Enzo; Christodoulidis, Stergios; Hoang-Thi, Trieu-Nghi; Dangeard, Severine; Deutsch, Eric; Andre, Fabrice; Guillo, Enora; Halm, Nara; El Hajj, Stefany; Bompard, Florian; Neveu, Sophie; Hani, Chahinez; Saab, Ines; Campredon, Alienor; Koulakian, Hasmik; Bennani, Souhail; Freche, Gael; Lombard, Aurelien; Fournier, Laure; Monnier, Hippolyte; Grand, Teodor; Gregory, Jules; Khalil, Antoine; Mahdjoub, Elyas; Brillet, Pierre-Yves; Tran Ba, Stephane; Bousson, Valerie; Revel, Marie-Pierre; Paragios, Nikos title: AI-Driven CT-based quantification, staging and short-term outcome prediction of COVID-19 pneumonia date: 2020-04-22 journal: nan DOI: 10.1101/2020.04.17.20069187 sha: doc_id: 277700 cord_uid: nxm1jr0x file: cache/cord-275828-c6d6nk7x.json key: cord-275828-c6d6nk7x authors: Mikasa, Keiichi; Aoki, Nobuki; Aoki, Yosuke; Abe, Shuichi; Iwata, Satoshi; Ouchi, Kazunobu; Kasahara, Kei; Kadota, Junichi; Kishida, Naoki; Kobayashi, Osamu; Sakata, Hiroshi; Seki, Masahumi; Tsukada, Hiroki; Tokue, Yutaka; Nakamura-Uchiyama, Fukumi; Higa, Futoshi; Maeda, Koichi; Yanagihara, Katsunori; Yoshida, Koichiro title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 journal: Journal of Infection and Chemotherapy DOI: 10.1016/j.jiac.2015.12.019 sha: doc_id: 275828 cord_uid: c6d6nk7x file: cache/cord-277399-0w8is9xm.json key: cord-277399-0w8is9xm authors: Esteves, Sandro C.; Lombardo, Francesco; Garrido, Nicolás; Alvarez, Juan; Zini, Armand; Colpi, Giovanni M.; Kirkman‐Brown, Jackson; Lewis, Sheena E. M.; Björndahl, Lars; Majzoub, Ahmad; Cho, Chak‐Lam; Vendeira, Pedro; Hallak, Jorge; Amar, Edouard; Cocuzza, Marcello; Bento, Fabiola C.; Figueira, Rita C.; Sciorio, Romualdo; Laursen, Rita J.; Metwalley, Ahmad M.; Jindal, Sunil K.; Parekattil, Sijo; Ramasamy, Ranjith; Alviggi, Carlo; Humaidan, Peter; Yovich, John L.; Agarwal, Ashok title: SARS‐CoV‐2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services date: 2020-05-22 journal: Andrology DOI: 10.1111/andr.12809 sha: doc_id: 277399 cord_uid: 0w8is9xm file: cache/cord-277430-x02u7oh0.json key: cord-277430-x02u7oh0 authors: Zhang, Hongyan; Wang, Linwei; Chen, Yuanyuan; Wu, Qiuji; Chen, Gaili; Shen, Xiaokun; Wang, Qun; Yan, Youqin; Yu, Yi; Zhong, Yahua; Wang, Xinghuan; Chua, Melvin L. K.; Xie, Conghua title: Outcomes of novel coronavirus disease 2019 (COVID‐19) infection in 107 patients with cancer from Wuhan, China date: 2020-06-23 journal: Cancer DOI: 10.1002/cncr.33042 sha: doc_id: 277430 cord_uid: x02u7oh0 file: cache/cord-277178-nbotxv35.json key: cord-277178-nbotxv35 authors: Vindrola-Padros, C.; Singh, K.; Sidhu, M. S.; Georghiou, T.; Sherlaw-Johnson, C.; Tomini, S. M.; Inada-Kim, M.; Kirkham, K.; Streetly, A.; Fulop, N. J. title: Remote home monitoring (virtual wards) during the COVID-19 pandemic: a living systematic review date: 2020-10-09 journal: nan DOI: 10.1101/2020.10.07.20208587 sha: doc_id: 277178 cord_uid: nbotxv35 file: cache/cord-277486-12uah5qi.json key: cord-277486-12uah5qi authors: Kopp, Kristen; Lichtenauer, Michael; Motloch, Lukas Jaroslaw; Hoppe, Uta C.; Egle, Alexander; Salzer, Helmut J. F.; Lamprecht, Bernd; Tomasits, Josef; Müller, Hannes M.; Dieplinger, Anna title: Interdisciplinary Model for Scheduling Post-discharge Cardiopulmonary Care of Patients Following Severe and Critical SARS-CoV-2 (Coronavirus) Infection date: 2020-08-14 journal: Front Cardiovasc Med DOI: 10.3389/fcvm.2020.00157 sha: doc_id: 277486 cord_uid: 12uah5qi file: cache/cord-277210-xaj2623u.json key: cord-277210-xaj2623u authors: Weinkove, Robert; McQuilten, Zoe K; Adler, Jonathan; Agar, Meera R; Blyth, Emily; Cheng, Allen C; Conyers, Rachel; Haeusler, Gabrielle M; Hardie, Claire; Jackson, Christopher; Lane, Steven W; Middlemiss, Tom; Mollee, Peter; Mulligan, Stephen P; Ritchie, David; Ruka, Myra; Solomon, Benjamin; Szer, Jeffrey; Thursky, Karin A; Wood, Erica M; Worth, Leon J; Yong, Michelle K; Slavin, Monica A; Teh, Benjamin W title: Managing haematology and oncology patients during the COVID‐19 pandemic: interim consensus guidance date: 2020-05-13 journal: Med J Aust DOI: 10.5694/mja2.50607 sha: doc_id: 277210 cord_uid: xaj2623u file: cache/cord-277323-jqr2hkv2.json key: cord-277323-jqr2hkv2 authors: Thampi, Swapna; Melvin Lee, Chang Chuan; Zhi Ng, Beatrice Hui; Anne Yap, Andrea Pek title: Considerations for resuscitation and transfer of paediatric patients with COVID-19 date: 2020-04-27 journal: Br J Anaesth DOI: 10.1016/j.bja.2020.04.063 sha: doc_id: 277323 cord_uid: jqr2hkv2 file: cache/cord-277818-8w15dz20.json key: cord-277818-8w15dz20 authors: Jaichenco, Andre L.; Lima, Luciana Cavalcanti title: Infectious Disease Considerations for the Operating Room date: 2018-02-09 journal: A Practice of Anesthesia for Infants and Children DOI: 10.1016/b978-0-323-42974-0.00050-1 sha: doc_id: 277818 cord_uid: 8w15dz20 file: cache/cord-277803-7p1qu2rf.json key: cord-277803-7p1qu2rf authors: Rubino, Francesco; Cohen, Ricardo V; Mingrone, Geltrude; le Roux, Carel W; Mechanick, Jeffrey I; Arterburn, David E; Vidal, Josep; Alberti, George; Amiel, Stephanie A; Batterham, Rachel L; Bornstein, Stefan; Chamseddine, Ghassan; Del Prato, Stefano; Dixon, John B; Eckel, Robert H; Hopkins, David; McGowan, Barbara M; Pan, An; Patel, Ameet; Pattou, François; Schauer, Philip R; Zimmet, Paul Z; Cummings, David E title: Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery date: 2020-05-07 journal: Lancet Diabetes Endocrinol DOI: 10.1016/s2213-8587(20)30157-1 sha: doc_id: 277803 cord_uid: 7p1qu2rf file: cache/cord-277811-j58qvyum.json key: cord-277811-j58qvyum authors: Mehrani, Hossein; Ghanei, Mostafa; Aslani, Jafar; Tabatabaei, Zahra title: Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis date: 2011-01-07 journal: Clin Proteomics DOI: 10.1186/1559-0275-8-2 sha: doc_id: 277811 cord_uid: j58qvyum file: cache/cord-278325-ykcd7d59.json key: cord-278325-ykcd7d59 authors: Cheung, Carmen Ka Man; Law, Man Fai; Lui, Grace Chung Yan; Wong, Sunny Hei; Wong, Raymond Siu Ming title: Coronavirus Disease 2019 (COVID-19): A Haematologist's Perspective date: 2020-07-28 journal: Acta Haematol DOI: 10.1159/000510178 sha: doc_id: 278325 cord_uid: ykcd7d59 file: cache/cord-278300-6cr9h7no.json key: cord-278300-6cr9h7no authors: Lu, X.; Wang, Y.; Chen, T.; Li, Y.; Wang, J.; Yan, F. title: Classification of COVID-19 in intensive care patients: towards rational and effective clinical triage date: 2020-04-11 journal: nan DOI: 10.1101/2020.04.09.20058909 sha: doc_id: 278300 cord_uid: 6cr9h7no file: cache/cord-278477-9a7gmzz3.json key: cord-278477-9a7gmzz3 authors: Huh, Kyungmin; Lee, Rugyeom; Ji, Wonjun; Kang, Minsun; Cheol Hwang, In; Ho Lee, Dae; Jung, Jaehun title: Impact of obesity, fasting plasma glucose level, blood pressure, and renal function on the severity of COVID-19: a matter of sexual dimorphism? date: 2020-10-21 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108515 sha: doc_id: 278477 cord_uid: 9a7gmzz3 file: cache/cord-276758-k2imddzr.json key: cord-276758-k2imddzr authors: Siegel, Jane D.; Rhinehart, Emily; Jackson, Marguerite; Chiarello, Linda title: 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings date: 2007-12-07 journal: Am J Infect Control DOI: 10.1016/j.ajic.2007.10.007 sha: doc_id: 276758 cord_uid: k2imddzr file: cache/cord-277889-8u685f45.json key: cord-277889-8u685f45 authors: Costela-Ruiz, Víctor J.; Illescas-Montes, Rebeca; Puerta-Puerta, Jose M.; Ruiz, Concepción; Melguizo-Rodríguez, Lucia title: SARS-CoV-2 infection: the role of cytokines in COVID-19 disease date: 2020-06-02 journal: Cytokine Growth Factor Rev DOI: 10.1016/j.cytogfr.2020.06.001 sha: doc_id: 277889 cord_uid: 8u685f45 file: cache/cord-278549-br9rr713.json key: cord-278549-br9rr713 authors: Madanelo, M.; Ferreira, C.; Nunes‐Carneiro, D.; Pinto, A.; Rocha, MA.; Correia, J.; Teixeira, B.; Mendes, G.; Tavares, C.; Mesquita, S.; Fraga, A. title: The impact of the COVID‐19 pandemic on the utilization of emergency urological services date: 2020-05-14 journal: BJU Int DOI: 10.1111/bju.15109 sha: doc_id: 278549 cord_uid: br9rr713 file: cache/cord-278364-58d8kfdf.json key: cord-278364-58d8kfdf authors: Mohapatra, S. title: Sterilization and Disinfection date: 2017-03-31 journal: Essentials of Neuroanesthesia DOI: 10.1016/b978-0-12-805299-0.00059-2 sha: doc_id: 278364 cord_uid: 58d8kfdf file: cache/cord-277739-eb4z3u66.json key: cord-277739-eb4z3u66 authors: Hu, Ke; Guan, Wei-jie; Bi, Ying; Zhang, Wei; Li, Lanjuan; Zhang, Boli; Liu, Qingquan; Song, Yuanlin; Li, Xingwang; Duan, Zhongping; Zheng, Qingshan; Yang, Zifeng; Liang, Jingyi; Han, Mingfeng; Ruan, Lianguo; Wu, Chaomin; Zhang, Yunting; Jia, Zhen-hua; Zhong, Nan-shan title: Efficacy and Safety of Lianhuaqingwen Capsules, a repurposed Chinese Herb, in Patients with Coronavirus disease 2019: A multicenter, prospective, randomized controlled trial date: 2020-05-16 journal: Phytomedicine DOI: 10.1016/j.phymed.2020.153242 sha: doc_id: 277739 cord_uid: eb4z3u66 file: cache/cord-278547-y0hvq0qf.json key: cord-278547-y0hvq0qf authors: Testori, Alberto; Alloisio, Marco; Errico, Valentina; Perroni, Gianluca; Gatzemeier, Wolfgang; Tinterri, Corrado title: Extraordinary emergency measures set up by a Breast Unit to prevent COVID‐19: Report of our experience date: 2020-06-25 journal: Breast J DOI: 10.1111/tbj.13920 sha: doc_id: 278547 cord_uid: y0hvq0qf file: cache/cord-277992-49mantab.json key: cord-277992-49mantab authors: Harikrishnan, S.; Mohanan, P.P.; Chopra, V.K.; Ambuj, Roy; Sanjay, G.; Manish, Bansal; Chakraborty, R.N.; Chandra, Sharad; Chattarjee, S.S.; Chopra, H.K.; Mathew, Cibu; Deb, P.K.; Goyal, A.; Goswami, K.C.; Gupta, R.; Guha, S.; Gupta, V.; Hasija, P.K.; Wardhan, Harsh; Jabir, A.; Jayagopal, P.B.; Kahali, D.; Katyal, V.K.; Kerkar, P.G.; Khanna, N.N.; Majumder, B.; Mandal, M.; Meena, C.B.; Naik, N.; Narain, V.K.; Pathak, L.A.; Ray, S.; Roy, D.; Sarma, D.; Shanmugasundaram, S.; Singh, B.P.; Tyagi, S.K.; Venugopal, K.; Wander, G.S.; Yadav, R.; Das, M.K. title: Cardiological society of India position statement on COVID-19 and heart failure date: 2020-05-13 journal: Indian Heart J DOI: 10.1016/j.ihj.2020.04.012 sha: doc_id: 277992 cord_uid: 49mantab file: cache/cord-277643-xh8z9v0m.json key: cord-277643-xh8z9v0m authors: Khatiwada, Asmita Priyadarshini; Shakya, Sujyoti; Shrestha, Sunil title: Paradigm shift of drug information centers during the COVID-19 pandemic date: 2020-07-20 journal: Drugs Ther Perspect DOI: 10.1007/s40267-020-00757-3 sha: doc_id: 277643 cord_uid: xh8z9v0m file: cache/cord-278937-lkuuftno.json key: cord-278937-lkuuftno authors: Beydon, N.; Gochicoa, L.; Jones, M.J.; Lands, L.C.; Lombardi, E.; Rosenfeld, M.; Sly, P.D.; Weiner, D.J.; Yilmaz, O. title: Lung function testing during a pandemic: an international perspective date: 2020-10-11 journal: Paediatr Respir Rev DOI: 10.1016/j.prrv.2020.10.001 sha: doc_id: 278937 cord_uid: lkuuftno file: cache/cord-278332-fbksw3om.json key: cord-278332-fbksw3om authors: Schlick, Cary Jo R.; Khorfan, Rhami; Odell, David D.; Merkow, Ryan P.; Bentrem, David J. title: Adequate Lymphadenectomy as a Quality Measure in Esophageal Cancer: Is there an Association with Treatment Approach? date: 2020-06-09 journal: Ann Surg Oncol DOI: 10.1245/s10434-020-08578-4 sha: doc_id: 278332 cord_uid: fbksw3om file: cache/cord-278672-pxzsntfg.json key: cord-278672-pxzsntfg authors: Milenkovic, Aleksandar; Jankovic, Dragan; Rajkovic, Petar title: Extensions and Adaptations of Existing Medical Information System in Order to Reduce Social Contacts During COVID-19 Pandemic date: 2020-06-16 journal: Int J Med Inform DOI: 10.1016/j.ijmedinf.2020.104224 sha: doc_id: 278672 cord_uid: pxzsntfg file: cache/cord-278943-f80ucqqp.json key: cord-278943-f80ucqqp authors: Calvillo-Argüelles, Oscar; Abdel-Qadir, Husam; Ky, Bonnie; Liu, Jennifer E.; Lopez-Mattei, Juan C.; Amir, Eitan; Thavendiranathan, Paaladinesh title: Modified Routine Cardiac Imaging Surveillance of Adult Cancer Patients and Survivors during the COVID-19 Pandemic date: 2020-04-16 journal: JACC CardioOncol DOI: 10.1016/j.jaccao.2020.04.001 sha: doc_id: 278943 cord_uid: f80ucqqp file: cache/cord-278106-ev1nx60h.json key: cord-278106-ev1nx60h authors: Cancarevic, Ivan; Tathineni, Praveena; Malik, Bilal Haider title: Coronavirus Disease 2019 (COVID-19) in Cancer Patients date: 2020-04-26 journal: Cureus DOI: 10.7759/cureus.7835 sha: doc_id: 278106 cord_uid: ev1nx60h file: cache/cord-278682-s4gfbsqy.json key: cord-278682-s4gfbsqy authors: Chan, W-M; Liu, D T L; Chan, P K S; Chong, K K L; Yuen, K S C; Chiu, T Y H; Tam, B S M; Ng, J S K; Lam, D S C title: Precautions in ophthalmic practice in a hospital with a major acute SARS outbreak: an experience from Hong Kong date: 2005-04-29 journal: Eye (Lond) DOI: 10.1038/sj.eye.6701885 sha: doc_id: 278682 cord_uid: s4gfbsqy file: cache/cord-278984-0zof6s4d.json key: cord-278984-0zof6s4d authors: El-Tallawy, Salah N.; Nalamasu, Rohit; Pergolizzi, Joseph V.; Gharibo, Christopher title: Pain Management During the COVID-19 Pandemic date: 2020-08-25 journal: Pain Ther DOI: 10.1007/s40122-020-00190-4 sha: doc_id: 278984 cord_uid: 0zof6s4d file: cache/cord-278319-44bvju3g.json key: cord-278319-44bvju3g authors: Gonzales, Ralph; Bartlett, John G.; Besser, Richard E.; Cooper, Richelle J.; Hickner, John M.; Hoffman, Jerome R.; Sande, Merle A. title: Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background date: 2001-06-30 journal: Annals of Emergency Medicine DOI: 10.1067/s0196-0644(01)70091-1 sha: doc_id: 278319 cord_uid: 44bvju3g file: cache/cord-278993-w5aa0elj.json key: cord-278993-w5aa0elj authors: Tonetti, Tommaso; Grasselli, Giacomo; Zanella, Alberto; Pizzilli, Giacinto; Fumagalli, Roberto; Piva, Simone; Lorini, Luca; Iotti, Giorgio; Foti, Giuseppe; Colombo, Sergio; Vivona, Luigi; Rossi, Sandra; Girardis, Massimo; Agnoletti, Vanni; Campagna, Anselmo; Gordini, Giovanni; Navalesi, Paolo; Boscolo, Annalisa; Graziano, Alessandro; Valeri, Ilaria; Vianello, Andrea; Cereda, Danilo; Filippini, Claudia; Cecconi, Maurizio; Locatelli, Franco; Bartoletti, Michele; Giannella, Maddalena; Viale, Pierluigi; Antonelli, Massimo; Nava, Stefano; Pesenti, Antonio; Ranieri, V. Marco title: Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy date: 2020-10-12 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00750-z sha: doc_id: 278993 cord_uid: w5aa0elj file: cache/cord-278536-b4eyegx5.json key: cord-278536-b4eyegx5 authors: Piazza, Gregory; Campia, Umberto; Hurwitz, Shelley; Snyder, Julia E.; Rizzo, Samantha M.; Pfeferman, Mariana B.; Morrison, Ruth B.; Leiva, Orly; Fanikos, John; Nauffal, Victor; Almarzooq, Zaid; Goldhaber, Samuel Z. title: Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19 date: 2020-11-03 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2020.08.070 sha: doc_id: 278536 cord_uid: b4eyegx5 file: cache/cord-278592-67y4f9av.json key: cord-278592-67y4f9av authors: Kurup, Asok; Chlebicki, M.P.; Ling, M.L.; Koh, T.H.; Tan, K.Y.; Lee, L.C.; Howe, K.B.M. title: Control of a hospital-wide vancomycin-resistant Enterococci outbreak date: 2008-03-24 journal: Am J Infect Control DOI: 10.1016/j.ajic.2007.06.005 sha: doc_id: 278592 cord_uid: 67y4f9av file: cache/cord-279052-8hxdfdls.json key: cord-279052-8hxdfdls authors: Boet, S.; Katznelson, R.; Castelluci, L. A.; Fergusson, D.; Gonevski, M.; Clarke, H.; Etherington, N.; Burns, J.; Gagne, S.; Djaiani, G.; Pollock, N. W.; Proulx, L.; Sun, L. Y.; Thavorn, K.; Wherrett, C.; Thompson, C.; Blatteau, J. E.; Louge, P.; Pignel, R.; Roth, V.; MacDonald, J. R.; Taljaard, M. title: Protocol for a multicentre randomized controlled trial of normobaric versus hyperbaric oxygen therapy for hypoxemic COVID-19 patients date: 2020-07-16 journal: nan DOI: 10.1101/2020.07.15.20154609 sha: doc_id: 279052 cord_uid: 8hxdfdls file: cache/cord-279134-s6c7m94h.json key: cord-279134-s6c7m94h authors: Chen, Haiyang; Wu, Xuan; Wang, Wei; Wang, Qiming title: When cancer encounters COVID-19 in China: what have we suffered, experienced and learned date: 2020-05-16 journal: Jpn J Clin Oncol DOI: 10.1093/jjco/hyaa077 sha: doc_id: 279134 cord_uid: s6c7m94h file: cache/cord-279158-dsnniuo6.json key: cord-279158-dsnniuo6 authors: Luo, Y.; Li, Y.; Dai, J. title: Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study date: 2020-05-22 journal: nan DOI: 10.1101/2020.05.18.20102509 sha: doc_id: 279158 cord_uid: dsnniuo6 file: cache/cord-279111-jaa45kyc.json key: cord-279111-jaa45kyc authors: Ieven, M.; Coenen, S.; Loens, K.; Lammens, C.; Coenjaerts, F.; Vanderstraeten, A.; Henriques-Normark, B.; Crook, D.; Huygen, K.; Butler, C.C.; Verheij, T.J.M.; Little, P.; Zlateva, K.; van Loon, A.; Claas, E.C.J.; Goossens, H. title: Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries date: 2018-02-12 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2018.02.004 sha: doc_id: 279111 cord_uid: jaa45kyc file: cache/cord-279435-ffgd2ets.json key: cord-279435-ffgd2ets authors: ALBalawi, Hani B title: COVID-19: Precautionary Guidelines for Ophthalmologists date: 2020-06-25 journal: Cureus DOI: 10.7759/cureus.8815 sha: doc_id: 279435 cord_uid: ffgd2ets file: cache/cord-278838-qraq5aho.json key: cord-278838-qraq5aho authors: Mirouse, Adrien; Vignon, Philippe; Piron, Prescillia; Robert, René; Papazian, Laurent; Géri, Guillaume; Blanc, Pascal; Guitton, Christophe; Guérin, Claude; Bigé, Naïke; Rabbat, Antoine; Lefebvre, Aurélie; Razazi, Keyvan; Fartoukh, Muriel; Mariotte, Eric; Bouadma, Lila; Ricard, Jean-Damien; Seguin, Amélie; Souweine, Bertrand; Moreau, Anne-Sophie; Faguer, Stanislas; Mari, Arnaud; Mayaux, Julien; Schneider, Francis; Stoclin, Annabelle; Perez, Pierre; Maizel, Julien; Lafon, Charles; Ganster, Frédérique; Argaud, Laurent; Girault, Christophe; Barbier, François; Lecuyer, Lucien; Lambert, Jérôme; Canet, Emmanuel title: Severe varicella-zoster virus pneumonia: a multicenter cohort study date: 2017-06-07 journal: Crit Care DOI: 10.1186/s13054-017-1731-0 sha: doc_id: 278838 cord_uid: qraq5aho file: cache/cord-278256-dmrtsxik.json key: cord-278256-dmrtsxik authors: Qiu, Haiyan; Wu, Junhua; Hong, Liang; Luo, Yunling; Song, Qifa; Chen, Dong title: Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study date: 2020-03-25 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(20)30198-5 sha: doc_id: 278256 cord_uid: dmrtsxik file: cache/cord-279299-5djtiomq.json key: cord-279299-5djtiomq authors: CAO, HUI-FANG; LIANG, ZHONG-HUI; FENG, YING; ZHANG, ZI-NAN; XU, JING; HE, HE title: A confirmed severe case of human infection with avian-origin influenza H7N9: A case report date: 2014-12-30 journal: Exp Ther Med DOI: 10.3892/etm.2014.2159 sha: doc_id: 279299 cord_uid: 5djtiomq file: cache/cord-279357-83hisxro.json key: cord-279357-83hisxro authors: de Leon, Jose; Ruan, Can-Jun; Verdoux, Hélène; Wang, Chuanyue title: Clozapine is strongly associated with the risk of pneumonia and inflammation date: 2020-04-16 journal: Gen Psychiatr DOI: 10.1136/gpsych-2019-100183 sha: doc_id: 279357 cord_uid: 83hisxro file: cache/cord-279456-oouylyx9.json key: cord-279456-oouylyx9 authors: Henchi, Sonia; Conti, Clara Benedetta; Vanoni, Nicolò; Repossi, Alice Claudia; Cipolla, Giuseppe; Marra, Mirko; Esposti, Elena; Fiini, Michela; Raimondi Cominesi, Irene; Crepaldi, Monica; Scozzafava, Mariano title: First COVID-19 sub-intensive respiratory unit in Europe: the Italian experience date: 2020-06-23 journal: Multidiscip Respir Med DOI: 10.4081/mrm.2020.682 sha: doc_id: 279456 cord_uid: oouylyx9 file: cache/cord-279056-mmcoqtb5.json key: cord-279056-mmcoqtb5 authors: Seirafianpour, Farnoosh; Sodagar, Sogand; Mohammad, Arash Pour; Panahi, Parsa; Mozafarpoor, Samaneh; Almasi, Simin; Goodarzi, Azadeh title: Cutaneous manifestations and considerations in COVID‐19 pandemic: A systematic review date: 2020-07-08 journal: Dermatol Ther DOI: 10.1111/dth.13986 sha: doc_id: 279056 cord_uid: mmcoqtb5 file: cache/cord-279480-nqp1pc9v.json key: cord-279480-nqp1pc9v authors: Ring, Laurence E.; Martinez, Rebecca; Bernstein, Kyra; Landau, Ruth title: What Obstetricians should know about Obstetric Anesthesia during the COVID-19 pandemic date: 2020-08-26 journal: Semin Perinatol DOI: 10.1016/j.semperi.2020.151277 sha: doc_id: 279480 cord_uid: nqp1pc9v file: cache/cord-279557-hk77e3pp.json key: cord-279557-hk77e3pp authors: Drosten, Christian; Seilmaier, Michael; Corman, Victor M; Hartmann, Wulf; Scheible, Gregor; Sack, Stefan; Guggemos, Wolfgang; Kallies, Rene; Muth, Doreen; Junglen, Sandra; Müller, Marcel A; Haas, Walter; Guberina, Hana; Röhnisch, Tim; Schmid-Wendtner, Monika; Aldabbagh, Souhaib; Dittmer, Ulf; Gold, Hermann; Graf, Petra; Bonin, Frank; Rambaut, Andrew; Wendtner, Clemens-Martin title: Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection date: 2013-06-17 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(13)70154-3 sha: doc_id: 279557 cord_uid: hk77e3pp file: cache/cord-279197-cesemos0.json key: cord-279197-cesemos0 authors: Block, Keith I. title: Integrative Cancer Therapies: Learning From COVID-19 date: 2020-06-21 journal: Integr Cancer Ther DOI: 10.1177/1534735420932652 sha: doc_id: 279197 cord_uid: cesemos0 file: cache/cord-279238-d49jvws2.json key: cord-279238-d49jvws2 authors: Folesani, Gianluca; Botta, Luca; Pacini, Davide title: Cardiac surgery model during COVID-19 pandemic: now it’s time to ramp up date: 2020-07-09 journal: Ann Thorac Surg DOI: 10.1016/j.athoracsur.2020.07.001 sha: doc_id: 279238 cord_uid: d49jvws2 file: cache/cord-279550-7u2hksxm.json key: cord-279550-7u2hksxm authors: Wang, Kai; Long, Quan-Xin; Deng, Hai-Jun; Hu, Jie; Gao, Qing-Zhu; Zhang, Gui-Ji; He, Chang-Long; Huang, Lu-Yi; Hu, Jie-Li; Chen, Juan; Tang, Ni; Huang, Ai-Long title: Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection date: 2020-08-03 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1143 sha: doc_id: 279550 cord_uid: 7u2hksxm file: cache/cord-279513-m4jdc8ua.json key: cord-279513-m4jdc8ua authors: Onesti, Concetta Elisa; Rugo, Hope S; Generali, Daniele; Peeters, Marc; Zaman, Khalil; Wildiers, Hans; Harbeck, Nadia; Martin, Miguel; Cristofanilli, Massimo; Cortes, Javier; Tjan-Heijnen, Vivianne; Hurvitz, Sara A; Berchem, Guy; Tagliamento, Marco; Campone, Mario; Bartsch, Rupert; De Placido, Sabino; Puglisi, Fabio; Rottey, Sylvie; Müller, Volkmar; Ruhstaller, Thomas; Machiels, Jean-Pascal; Conte, PierFranco; Awada, Ahmad; Jerusalem, Guy title: Oncological care organisation during COVID-19 outbreak date: 2020-08-26 journal: ESMO Open DOI: 10.1136/esmoopen-2020-000853 sha: doc_id: 279513 cord_uid: m4jdc8ua file: cache/cord-279396-qmixem8i.json key: cord-279396-qmixem8i authors: Carter, Chris; Notter, Joy title: COVID-19 Disease: a critical care perspective date: 2020-06-01 journal: nan DOI: 10.1016/j.intcar.2020.100003 sha: doc_id: 279396 cord_uid: qmixem8i file: cache/cord-279570-lgbqpfh5.json key: cord-279570-lgbqpfh5 authors: Fragkou, Paraskevi C.; Thomas, Konstantinos; Sympardi, Styliani; Liatsos, George D.; Pirounaki, Maria; Sambatakou, Helen; Marantos, Theodoros; Karofylakis, Emmanouil; Dourakis, Spyridon P.; Tsiodras, Sotirios; Kavvatha, Dimitra title: Clinical characteristics and outcomes of measles outbreak in adults: a multicenter retrospective observational study of 93 hospitalized adults in Greece date: 2020-08-26 journal: J Clin Virol DOI: 10.1016/j.jcv.2020.104608 sha: doc_id: 279570 cord_uid: lgbqpfh5 file: cache/cord-279667-ikfduu2k.json key: cord-279667-ikfduu2k authors: Ronnje, Louise; Länsberg, John-Kalle; Vikhareva, Olga; Hansson, Stefan R.; Herbst, Andreas; Zaigham, Mehreen title: Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery date: 2020-09-04 journal: BMC Pregnancy Childbirth DOI: 10.1186/s12884-020-03172-8 sha: doc_id: 279667 cord_uid: ikfduu2k file: cache/cord-279846-g0ro8pbb.json key: cord-279846-g0ro8pbb authors: Terrigno, Vittorio R; Tan, Jian Liang; Singh, Devinder; Sabir, Sajjad A title: Right Atrial Thrombus in a Patient With COVID-19 date: 2020-07-28 journal: Cureus DOI: 10.7759/cureus.9441 sha: doc_id: 279846 cord_uid: g0ro8pbb file: cache/cord-279732-cea0nt8z.json key: cord-279732-cea0nt8z authors: Bentley, Suzanne K.; Iavicoli, Laura; Cherkas, David; Lane, Rikki; Wang, Ellen; Atienza, Maria; Fairweather, Phillip; Kessler, Stuart title: Guidance and Patient Instructions for Proning and Repositioning of Awake, Non‐Intubated COVID‐19 Patients date: 2020-06-29 journal: Acad Emerg Med DOI: 10.1111/acem.14067 sha: doc_id: 279732 cord_uid: cea0nt8z file: cache/cord-279790-zzvetjrt.json key: cord-279790-zzvetjrt authors: Zeng, Liujun; Su, Tong; Huang, Long title: Strategic plan for management in oral and maxillofacial surgery during COVID-19 epidemic date: 2020-04-11 journal: Oral Oncol DOI: 10.1016/j.oraloncology.2020.104715 sha: doc_id: 279790 cord_uid: zzvetjrt file: cache/cord-279571-chiadufa.json key: cord-279571-chiadufa authors: Cui, Xiaoyang; Yu, Xin; Wu, Xiaojing; Huang, Linna; Tian, Ye; Huang, Xu; Zhang, Zeyu; Cheng, Zhenshun; Guo, Qiang; Zhang, Yi; Cai, Ying; Zhan, Qingyuan title: Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study date: 2020-07-24 journal: Kidney Blood Press Res DOI: 10.1159/000509517 sha: doc_id: 279571 cord_uid: chiadufa file: cache/cord-280070-c1bkhgaz.json key: cord-280070-c1bkhgaz authors: Azadeh, Natalya; Limper, Andrew H.; Carmona, Eva M.; Ryu, Jay H. title: The Role of Infection in Interstitial Lung Diseases A Review date: 2017-10-31 journal: Chest DOI: 10.1016/j.chest.2017.03.033 sha: doc_id: 280070 cord_uid: c1bkhgaz file: cache/cord-279719-z0wuajpx.json key: cord-279719-z0wuajpx authors: Martin-Fumadó, Carles; Gómez-Durán, Esperanza L.; Morlans-Molina, Màrius title: Medico-legal and ethical considerations on resource limitation and clinical decisions during the COVID-19 pandemic date: 2020-07-15 journal: nan DOI: 10.1016/j.remle.2020.05.004 sha: doc_id: 279719 cord_uid: z0wuajpx file: cache/cord-279483-gwikyux2.json key: cord-279483-gwikyux2 authors: Wong, Joshua Guoxian; Aung, Aung-Hein; Lian, Weixiang; Lye, David Chien; Ooi, Chee-Kheong; Chow, Angela title: Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department date: 2020-11-02 journal: Antimicrob Resist Infect Control DOI: 10.1186/s13756-020-00825-3 sha: doc_id: 279483 cord_uid: gwikyux2 file: cache/cord-280129-a97rvtzl.json key: cord-280129-a97rvtzl authors: Honore, Patrick M.; Barreto Gutierrez, Leonel; Kugener, Luc; Redant, Sebastien; Attou, Rachid; Gallerani, Andrea; De Bels, David title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation date: 2020-06-16 journal: Crit Care DOI: 10.1186/s13054-020-03088-x sha: doc_id: 280129 cord_uid: a97rvtzl file: cache/cord-280097-f7ky61ds.json key: cord-280097-f7ky61ds authors: Zarogoulidis, Paul; Constantinidis, Theodoros; Steiropoulos, Paschalis; Papanas, Nikolaos; Zarogoulidis, Kostas; Maltezos, Efstratios title: Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? date: 2011-01-07 journal: BMC Res Notes DOI: 10.1186/1756-0500-4-4 sha: doc_id: 280097 cord_uid: f7ky61ds file: cache/cord-280278-gq1hnnwh.json key: cord-280278-gq1hnnwh authors: Chi, Meng; Lou, Changming; Zhao, Xiuli; Sui, Xin; Han, Fei title: A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management date: 2020-06-08 journal: Crit Care DOI: 10.1186/s13054-020-02985-5 sha: doc_id: 280278 cord_uid: gq1hnnwh file: cache/cord-279736-udsbcqfs.json key: cord-279736-udsbcqfs authors: Abdalkader, Mohamad; Sathya, Anvitha; Malek, Adel M.; Fifi, Johanna T.; Norbash, Alexander M.; Wakhloo, Ajay K.; Nguyen, Thanh N. title: Roadmap for Resuming Elective Neuroendovascular Procedures Following the First COVID-19 Surge date: 2020-07-27 journal: J Stroke Cerebrovasc Dis DOI: 10.1016/j.jstrokecerebrovasdis.2020.105177 sha: doc_id: 279736 cord_uid: udsbcqfs file: cache/cord-280005-i9fp5rys.json key: cord-280005-i9fp5rys authors: Wang, Mengmei; Zhao, Yang; Hu, Weihua; Zhao, Dong; Zhang, Yunting; Wang, Tao; Zheng, Zhishui; Li, Xiaochen; Zeng, Shaolin; Liu, Zhenlian; Lu, Li; Wan, Zhihui; Hu, Ke title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -- a Single-Center, Randomized, Controlled Clinical Trial date: 2020-09-21 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1417 sha: doc_id: 280005 cord_uid: i9fp5rys file: cache/cord-280507-1nf2ycp3.json key: cord-280507-1nf2ycp3 authors: Álvarez‐Román, MT; García‐Barcenilla, S; Cebanu, T; González‐Zorrilla, E; Butta, NV; Bello‐Fernández, I; Martín‐Salces, M; Pollmar‐Rivas, I; Jiménez‐Yuste, V title: Clinical trials and Haemophilia during the COVID‐19’ pandemic: Madrid’s Experience date: 2020-05-16 journal: Haemophilia DOI: 10.1111/hae.14055 sha: doc_id: 280507 cord_uid: 1nf2ycp3 file: cache/cord-280060-gzby85u9.json key: cord-280060-gzby85u9 authors: Rello, Jordi; Manuel, Oriol; Eggimann, Philippe; Richards, Guy; Wejse, Christian; Petersen, Jorgen Eskild; Zacharowski, Kai; Leblebicioglu, Hakan title: Management of infections in critically ill returning travellers in the intensive care unit—II: clinical syndromes and special considerations in immunocompromised patients() date: 2016-04-28 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2016.04.020 sha: doc_id: 280060 cord_uid: gzby85u9 file: cache/cord-280111-6hiuzkvz.json key: cord-280111-6hiuzkvz authors: Maspero, Cinzia; Abate, Andrea; Cavagnetto, Davide; El Morsi, Mohamed; Fama, Andrea; Farronato, Marco title: Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic date: 2020-06-17 journal: J Clin Med DOI: 10.3390/jcm9061891 sha: doc_id: 280111 cord_uid: 6hiuzkvz file: cache/cord-280280-9jr7ekbu.json key: cord-280280-9jr7ekbu authors: Bertoncelli, Deborah; Guidarini, Marta; Della Greca, Anna; Ratti, Chiara; Falcinella, Francesca; Iovane, Brunella; Dutto, Mauro Luigi; Caffarelli, Carlo; Tchana, Bertrand title: COVID19: potential cardiovascular issues in pediatric patients date: 2020-05-11 journal: Acta Biomed DOI: 10.23750/abm.v91i2.9655 sha: doc_id: 280280 cord_uid: 9jr7ekbu file: cache/cord-280360-rh37d5wc.json key: cord-280360-rh37d5wc authors: Gibson, David S.; Blelock, Sarah; Curry, Jim; Finnegan, Sorcha; Healy, Adrienne; Scaife, Caitriona; McAllister, Catherine; Pennington, Stephen; Dunn, Michael; Rooney, Madeleine title: Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease date: 2009-05-02 journal: J Proteomics DOI: 10.1016/j.jprot.2009.01.022 sha: doc_id: 280360 cord_uid: rh37d5wc file: cache/cord-280628-ok62havd.json key: cord-280628-ok62havd authors: Groß, Sonja; Jahn, Christopher; Cushman, Sarah; Bär, Christian; Thum, Thomas title: SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications date: 2020-04-30 journal: J Mol Cell Cardiol DOI: 10.1016/j.yjmcc.2020.04.031 sha: doc_id: 280628 cord_uid: ok62havd file: cache/cord-280348-vrnxucye.json key: cord-280348-vrnxucye authors: Argano, Christiano; Scichilone, Nicola; Natoli, Giuseppe; Nobili, Alessandro; Corazza, Gino Roberto; Mannucci, Pier Mannuccio; Perticone, Francesco; Corrao, Salvatore title: Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry date: 2020-07-27 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02412-1 sha: doc_id: 280348 cord_uid: vrnxucye file: cache/cord-280848-z0sbztkw.json key: cord-280848-z0sbztkw authors: Setzen, Michael; Svider, Peter F.; Pollock, Kim title: COVID-19 and rhinology: A look at the future date: 2020-04-15 journal: Am J Otolaryngol DOI: 10.1016/j.amjoto.2020.102491 sha: doc_id: 280848 cord_uid: z0sbztkw file: cache/cord-280030-neqycg6v.json key: cord-280030-neqycg6v authors: Sewlall, Nivesh H.; Richards, Guy; Duse, Adriano; Swanepoel, Robert; Paweska, Janusz; Blumberg, Lucille; Dinh, Thu Ha; Bausch, Daniel title: Clinical Features and Patient Management of Lujo Hemorrhagic Fever date: 2014-11-13 journal: PLoS Negl Trop Dis DOI: 10.1371/journal.pntd.0003233 sha: doc_id: 280030 cord_uid: neqycg6v file: cache/cord-280233-avmisu31.json key: cord-280233-avmisu31 authors: Chase, J. Geoffrey; Chiew, Yeong Shiong; Lambermont, Bernard; Morimont, Philippe; Shaw, Geoffrey M.; Desaive, Thomas title: Safe doubling of ventilator capacity: a last resort proposal for last resorts date: 2020-05-14 journal: Crit Care DOI: 10.1186/s13054-020-02945-z sha: doc_id: 280233 cord_uid: avmisu31 file: cache/cord-280241-h16s6wwm.json key: cord-280241-h16s6wwm authors: McStay, R.; Johnstone, A.; Hare, S. S.; Rodrigues, J.C.L.; Nair, A.; Jacob, J.; Edey, A.; Robinson, G. title: COVID-19: looking beyond the peak. Challenges and tips for radiologists in follow-up of a novel patient cohort date: 2020-10-08 journal: Clin Radiol DOI: 10.1016/j.crad.2020.09.025 sha: doc_id: 280241 cord_uid: h16s6wwm file: cache/cord-280821-kc0ut4oy.json key: cord-280821-kc0ut4oy authors: Venturini, Elisabetta; Montagnani, Carlotta; Garazzino, Silvia; Donà, Daniele; Pierantoni, Luca; Lo Vecchio, Andrea; Nicolini, Giangiacomo; Bianchini, Sonia; Krzysztofiak, Andrzej; Galli, Luisa; Villani, Alberto; Castelli-Gattinara, Guido title: Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date: 2020-09-24 journal: Ital J Pediatr DOI: 10.1186/s13052-020-00900-w sha: doc_id: 280821 cord_uid: kc0ut4oy file: cache/cord-280984-2j8ckz14.json key: cord-280984-2j8ckz14 authors: Roux, CH; Brocq, O; Gerald, F; Pradier, C; Bailly, L title: Impact of home confinement during the COVID‐19 pandemic on medication use and disease activity in spondyloarthritis patients date: 2020-06-17 journal: Arthritis Rheumatol DOI: 10.1002/art.41397 sha: doc_id: 280984 cord_uid: 2j8ckz14 file: cache/cord-280996-anq680a1.json key: cord-280996-anq680a1 authors: Agarwal, Arnav; Basmaji, John; Muttalib, Fiona; Granton, David; Chaudhuri, Dipayan; Chetan, Devin; Hu, Malini; Fernando, Shannon M.; Honarmand, Kimia; Bakaa, Layla; Brar, Sonia; Rochwerg, Bram; Adhikari, Neill K.; Lamontagne, Francois; Murthy, Srinivas; Hui, David S. C.; Gomersall, Charles; Mubareka, Samira; Diaz, Janet V.; Burns, Karen E. A.; Couban, Rachel; Ibrahim, Quazi; Guyatt, Gordon H.; Vandvik, Per O. title: High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission date: 2020-06-15 journal: Can J Anaesth DOI: 10.1007/s12630-020-01740-2 sha: doc_id: 280996 cord_uid: anq680a1 file: cache/cord-280961-fka8c69p.json key: cord-280961-fka8c69p authors: Zhang, Rui; Ouyang, Huangqing; Fu, Lingli; Wang, Shijie; Han, Jianglong; Huang, Kejie; Jia, Mingfang; Song, Qibin; Fu, Zhenming title: CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city date: 2020-04-11 journal: Eur Radiol DOI: 10.1007/s00330-020-06854-1 sha: doc_id: 280961 cord_uid: fka8c69p file: cache/cord-280431-tuzdng4h.json key: cord-280431-tuzdng4h authors: Alinier, Guillaume title: 5 Basing a Nonclinician's Career upon Simulation The Personal Experience of a Physicist date: 2008-12-31 journal: Clinical Simulation DOI: 10.1016/b978-012372531-8.50013-3 sha: doc_id: 280431 cord_uid: tuzdng4h file: cache/cord-280944-uphs5gvl.json key: cord-280944-uphs5gvl authors: Stagnell, S.; Moore, R. title: COVID and consent date: 2020-07-10 journal: Br Dent J DOI: 10.1038/s41415-020-1903-1 sha: doc_id: 280944 cord_uid: uphs5gvl file: cache/cord-281060-1ud5hzlh.json key: cord-281060-1ud5hzlh authors: Méndez Maestro, Irune; Peña Merino, Lander; Udondo González del Tánago, Begoña; Aramburu González, Aida; Orbea Sopeña, Ana; Sánchez De Vicente, Javier; Ratón Nieto, Juan A.; Acebo Mariñas, Elvira; Gardeazabal García, Jesús title: Skin manifestations in patients hospitalized with confirmed COVID‐19 disease: a cross‐sectional study in a tertiary hospital date: 2020-09-24 journal: Int J Dermatol DOI: 10.1111/ijd.15180 sha: doc_id: 281060 cord_uid: 1ud5hzlh file: cache/cord-281003-7pdhxdzc.json key: cord-281003-7pdhxdzc authors: Farmakis, Dimitrios; Giakoumis, Anastasios; Cannon, Lily; Angastiniotis, Michael; Eleftheriou, Androulla title: COVID‐19 and thalassaemia: A position statement of the Thalassaemia International Federation date: 2020-07-13 journal: Eur J Haematol DOI: 10.1111/ejh.13476 sha: doc_id: 281003 cord_uid: 7pdhxdzc file: cache/cord-281130-9tawihti.json key: cord-281130-9tawihti authors: Schirinzi, Annalisa; Pesce, Francesco; Laterza, Riccardo; D'Alise, Maria Gabriella; Lovero, Roberto; Fontana, Antonietta; Contino, Renato; Serio, Francesca Di title: Pentraxin 3: Potential prognostic role in SARS-CoV-2 patients admitted to the emergency department date: 2020-11-02 journal: J Infect DOI: 10.1016/j.jinf.2020.10.027 sha: doc_id: 281130 cord_uid: 9tawihti file: cache/cord-280551-9hoxy5ok.json key: cord-280551-9hoxy5ok authors: Kim, Donghee; Adeniji, Nia; Latt, Nyann; Kumar, Sonal; Bloom, Patricia P.; Aby, Elizabeth S.; Perumalswami, Ponni; Roytman, Marina; Li, Michael; Vogel, Alexander S.; Catana, Andreea M.; Wegermann, Kara; Carr, Rotonya M.; Aloman, Costica; Chen, Vincent; Rabiee, Atoosa; Sadowski, Brett; Nguyen, Veronica; Dunn, Winston; Chavin, Kenneth; Zhou, Kali; Lizaola-Mayo, Blanca; Moghe, Akshata; Debes, José; Lee, Tzu-Hao; Branch, Andrea; Viveiros, Kathleen; Chan, Walter; Chascsa, David; Kwo, Paul; Dhanasekaran, Renumathy title: Predictors of Outcomes of COVID-19 in Patients with Chronic Liver Disease: US Multi-center Study date: 2020-09-17 journal: Clin Gastroenterol Hepatol DOI: 10.1016/j.cgh.2020.09.027 sha: doc_id: 280551 cord_uid: 9hoxy5ok file: cache/cord-280554-9jp85yzz.json key: cord-280554-9jp85yzz authors: Lamure, Sylvain; Duléry, Rémy; Di Blasi, Roberta; Chauchet, Adrien; Laureana, Cécile; Deau-Fischer, Bénédicte; Drenou, Bernard; Soussain, Carole; Rossi, Cédric; Noël, Nicolas; Choquet, Sylvain; Bologna, Serge; Joly, Bertrand; Kohn, Milena; Malak, Sandra; Fouquet, Guillemette; Daguindau, Etienne; Bernard, Sophie; Thiéblemont, Catherine; Cartron, Guillaume; Lacombe, Karine; Besson, Caroline title: Determinants of outcome in Covid-19 hospitalized patients with lymphoma: A retrospective multicentric cohort study date: 2020-10-13 journal: EClinicalMedicine DOI: 10.1016/j.eclinm.2020.100549 sha: doc_id: 280554 cord_uid: 9jp85yzz file: cache/cord-280794-k591vqji.json key: cord-280794-k591vqji authors: Bauer, Melissa E.; Chiware, Ruth; Pancaro, Carlo title: Neuraxial Procedures in COVID-19–Positive Parturients: A Review of Current Reports date: 2020-04-20 journal: Anesth Analg DOI: 10.1213/ane.0000000000004831 sha: doc_id: 280794 cord_uid: k591vqji file: cache/cord-281039-a7q5nzwn.json key: cord-281039-a7q5nzwn authors: Rodilla, Enrique; Saura, Alberto; Jiménez, Iratxe; Mendizábal, Andrea; Pineda-Cantero, Araceli; Lorenzo-Hernández, Elizabeth; Fidalgo-Montero, Maria del Pilar; López-Cuervo, Joaquín Fernandez; Gil-Sánchez, Ricardo; Rabadán-Pejenaute, Elisa; Abella-Vázquez, Lucy; Giner-Galvañ, Vicente; Solís-Marquínez, Marta Nataya; Boixeda, Ramon; de la Peña-Fernández, Andrés; Carrasco-Sánchez, Francisco Javier; González-Moraleja, Julio; Torres-Peña, José David; Guisado-Espartero, María Esther; Escobar-Sevilla, Joaquín; Guzmán-García, Marcos; Martín-Escalante, María Dolores; Martínez-González, Ángel Luis; Casas-Rojo, José Manuel; Gómez-Huelgas, Ricardo title: Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 date: 2020-09-28 journal: J Clin Med DOI: 10.3390/jcm9103136 sha: doc_id: 281039 cord_uid: a7q5nzwn file: cache/cord-280358-ru2hv6pz.json key: cord-280358-ru2hv6pz authors: Auvinen, R.; Nohynek, H.; Syrjänen, R.; Ollgren, J.; Kerttula, T.; Mäntylä, J.; Ikonen, N.; Loginov, R.; Haveri, A.; Kurkela, S.; Skogberg, K. title: Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients: a prospective observational study date: 2020-06-29 journal: nan DOI: 10.1101/2020.06.29.20140632 sha: doc_id: 280358 cord_uid: ru2hv6pz file: cache/cord-281064-b69p44uq.json key: cord-281064-b69p44uq authors: Ozder, Aclan title: A Novel Indicator Predicts 2019 Novel Coronavirus Infection in Subjects with Diabetes date: 2020-07-03 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108294 sha: doc_id: 281064 cord_uid: b69p44uq file: cache/cord-281276-rffp6qe2.json key: cord-281276-rffp6qe2 authors: Rhazi, Karima El; Adarmouch, Latifa title: Ethical issues related to the hydroxychloroquine treatment prescription for Covid-19 date: 2020-06-17 journal: Ethics Med Public Health DOI: 10.1016/j.jemep.2020.100547 sha: doc_id: 281276 cord_uid: rffp6qe2 file: cache/cord-281283-h6yai7sx.json key: cord-281283-h6yai7sx authors: Ma, Jun; Zhong, Hao; Jiang, Min; Zeng, Kuan; Zhong, Baoliang; Liu, Lianzhong; Liu, Xuebing title: Emergency response strategy for containing COVID-19 within a psychiatric specialty hospital in the epicenter of the COVID-19 epidemic in China date: 2020-08-04 journal: Transl Psychiatry DOI: 10.1038/s41398-020-00959-3 sha: doc_id: 281283 cord_uid: h6yai7sx file: cache/cord-281106-vzb5xzza.json key: cord-281106-vzb5xzza authors: Zerwes, S.; Steinbauer, M.; Gosslau, Y.; Warm, T.; Hyhlik-Dürr, A. title: COVID-19-Infektion – Risiko für thrombembolische Komplikationen date: 2020-09-01 journal: Gefasschirurgie DOI: 10.1007/s00772-020-00687-4 sha: doc_id: 281106 cord_uid: vzb5xzza file: cache/cord-281175-og3myz22.json key: cord-281175-og3myz22 authors: Tapper, Elliot B.; Asrani, Sumeet K. title: The COVID-19 pandemic will have a long-lasting impact on the quality of cirrhosis care date: 2020-04-13 journal: J Hepatol DOI: 10.1016/j.jhep.2020.04.005 sha: doc_id: 281175 cord_uid: og3myz22 file: cache/cord-281346-bjhdy8mg.json key: cord-281346-bjhdy8mg authors: Palacios Cruz, M.; Santos, E.; Velázquez Cervantes, M.A.; León Juárez, M. title: COVID-19, a worldwide public health emergency() date: 2020-04-21 journal: Rev Clin Esp (Barc) DOI: 10.1016/j.rceng.2020.03.001 sha: doc_id: 281346 cord_uid: bjhdy8mg file: cache/cord-281332-5mddyv0n.json key: cord-281332-5mddyv0n authors: Wilson, Michael R.; Suan, Dan; Duggins, Andrew; Schubert, Ryan D.; Khan, Lillian M.; Sample, Hannah A.; Zorn, Kelsey C.; Rodrigues Hoffman, Aline; Blick, Anna; Shingde, Meena; DeRisi, Joseph L. title: A novel cause of chronic viral meningoencephalitis: Cache Valley virus date: 2017-07-25 journal: Ann Neurol DOI: 10.1002/ana.24982 sha: doc_id: 281332 cord_uid: 5mddyv0n file: cache/cord-281561-r10y2sgb.json key: cord-281561-r10y2sgb authors: Tiwari, Nidhi; Upadhyay, Jyoti; Nazam Ansari, Mohd; Joshi, Rohit title: Novel β-Coronavirus (SARS-CoV-2): Current and Future Aspects of Pharmacological Treatments date: 2020-08-27 journal: Saudi Pharm J DOI: 10.1016/j.jsps.2020.08.015 sha: doc_id: 281561 cord_uid: r10y2sgb file: cache/cord-281391-0qkku2jd.json key: cord-281391-0qkku2jd authors: Miller-Handley, Hilary; Luckett, Keith; Govil, Amit title: Treatment Options for COVID-19 in Patients with Reduced or Absent Kidney Function date: 2020-09-17 journal: Adv Chronic Kidney Dis DOI: 10.1053/j.ackd.2020.09.001 sha: doc_id: 281391 cord_uid: 0qkku2jd file: cache/cord-281752-64mrflcr.json key: cord-281752-64mrflcr authors: Vespignani, Hervé; Colas, Damien; Lavin, Bruce S.; Soufflet, Christine; Maillard, Louis; Pourcher, Valérie; Paccoud, Olivier; Medjebar, Samir; Frouin, Pierre‐Yves title: Report of EEG Finding on Critically Ill Patients with COVID‐19 date: 2020-06-13 journal: Ann Neurol DOI: 10.1002/ana.25814 sha: doc_id: 281752 cord_uid: 64mrflcr file: cache/cord-281887-b511bjdy.json key: cord-281887-b511bjdy authors: Ribeiro, Reitan; Wainstein, Alberto Julius Alves; de Castro Ribeiro, Heber Salvador; Pinheiro, Rodrigo Nascimento; Oliveira, Alexandre Ferreira title: Perioperative Cancer Care in the Context of Limited Resources during the COVID-19 Pandemic: Brazilian Society of Surgical Oncology Recommendations date: 2020-09-26 journal: Ann Surg Oncol DOI: 10.1245/s10434-020-09098-x sha: doc_id: 281887 cord_uid: b511bjdy file: cache/cord-281945-jvnjzjds.json key: cord-281945-jvnjzjds authors: Radnis, Caitlin; Qiu, Sunny; Jhaveri, Miral; DaSilva, Ivan; Szewka, Aimee; Koffman, Lauren title: Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia date: 2020-09-06 journal: J Neurol Sci DOI: 10.1016/j.jns.2020.117119 sha: doc_id: 281945 cord_uid: jvnjzjds file: cache/cord-281344-iswbgqqe.json key: cord-281344-iswbgqqe authors: Jonker, Leonie T.; Lahr, Maarten M.H.; Festen, Suzanne; Oonk, Maaike H.M.; de Bock, Geertruida H.; van Leeuwen, Barbara L. title: Perioperative telemonitoring of older adults with cancer: Can we connect them all? date: 2020-09-04 journal: J Geriatr Oncol DOI: 10.1016/j.jgo.2020.08.008 sha: doc_id: 281344 cord_uid: iswbgqqe file: cache/cord-281566-6v5zfue6.json key: cord-281566-6v5zfue6 authors: Hamilos, Daniel L. title: Host-microbial interactions in patients with chronic rhinosinusitis date: 2013-11-28 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2013.06.049 sha: doc_id: 281566 cord_uid: 6v5zfue6 file: cache/cord-282183-k0pn0ie2.json key: cord-282183-k0pn0ie2 authors: Spiezia, Luca; Campello, Elena; Cola, Marco; Poletto, Francesco; Cerruti, Lorenzo; Poretto, Anna; Simion, Chiara; Cattelan, Annamaria; Vettor, Roberto; Simioni, Paolo title: More severe hypercoagulable state in acute COVID-19 pneumonia as compared to other pneumonia. date: 2020-10-01 journal: Mayo Clin Proc Innov Qual Outcomes DOI: 10.1016/j.mayocpiqo.2020.09.002 sha: doc_id: 282183 cord_uid: k0pn0ie2 file: cache/cord-281298-qheq9lc8.json key: cord-281298-qheq9lc8 authors: Merks, Piotr; Jakubowska, Marta; Drelich, Ewelina; Świeczkowski, Damian; Bogusz, Joanna; Bilmin, Krzysztof; Sola, Katarina Fehir; May, Andreas; Majchrowska, Anita; Koziol, Mark; Pawlikowski, Jakub; Jaguszewski, Miłosz; Vaillancourt, Regis title: The legal extension of the role of pharmacists in light of the COVID-19 global pandemic date: 2020-06-12 journal: Res Social Adm Pharm DOI: 10.1016/j.sapharm.2020.05.033 sha: doc_id: 281298 cord_uid: qheq9lc8 file: cache/cord-282483-0zsvhoog.json key: cord-282483-0zsvhoog authors: Ghisa, Matteo; Barberio, Brigida; Lorenzon, Greta; Zingone, Fabiana; Savarino, Edoardo title: Reorganization of the Functional Gastrointestinal Disorders Unit during the SARS-CoV-2 Outbreak - Practical Recommendations date: 2020-07-10 journal: Dig Liver Dis DOI: 10.1016/j.dld.2020.07.011 sha: doc_id: 282483 cord_uid: 0zsvhoog file: cache/cord-282097-a1pwq4fi.json key: cord-282097-a1pwq4fi authors: Hoertel, N.; Sanchez, M.; Vernet, R.; Beeker, N.; Neuraz, A.; Alvarado, J.; Daniel, C.; Paris, N.; Gramfort, A.; Lemaitre, G.; Salamanca, E.; Bernaux, M.; Bellamine, A.; Burgun, A.; Limosin, F. title: Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study date: 2020-10-27 journal: nan DOI: 10.1101/2020.10.23.20218172 sha: doc_id: 282097 cord_uid: a1pwq4fi file: cache/cord-282219-7kzbnymp.json key: cord-282219-7kzbnymp authors: Wu, Liu; Dong, Yuting; Li, Jin; Huang, Ju; Wen, Dengpeng; Peng, Tao; Luo, Jian title: The effect of massage on the quality of life in patients recovering from COVID-19: A systematic review protocol date: 2020-06-05 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000020529 sha: doc_id: 282219 cord_uid: 7kzbnymp file: cache/cord-281729-z321pebe.json key: cord-281729-z321pebe authors: Santos, Cláudia; Oliveira, Rui Caetano; Serra, Paula; Baptista, João Pedro; Sousa, Eduardo; Casanova, Paula; Pimentel, Jorge; Carvalho, Lina title: Pathophysiology of acute fibrinous and organizing pneumonia – Clinical and morphological spectra date: 2019-05-02 journal: Pathophysiology DOI: 10.1016/j.pathophys.2019.04.001 sha: doc_id: 281729 cord_uid: z321pebe file: cache/cord-281733-bsq0ewac.json key: cord-281733-bsq0ewac authors: Veyseh, Maedeh; Pophali, Prateek; Jayarangaiah, Apoorva; Kumar, Abhishek title: Left gonadal vein thrombosis in a patient with COVID-19-associated coagulopathy date: 2020-09-07 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-236786 sha: doc_id: 281733 cord_uid: bsq0ewac file: cache/cord-282043-cs1oyohu.json key: cord-282043-cs1oyohu authors: Giustino, Gennaro; Pinney, Sean P.; Lala, Anuradha; Reddy, Vivek Y.; Johnston-Cox, Hillary A.; Mechanick, Jeffrey I.; Halperin, Jonathan L.; Fuster, Valentin title: Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC Focus Seminar date: 2020-10-27 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2020.08.059 sha: doc_id: 282043 cord_uid: cs1oyohu file: cache/cord-282361-gje78nb1.json key: cord-282361-gje78nb1 authors: Gökce, Mehmet İlker; Yin, Shanfeng; Sönmez, Mehmet Giray; Eryildirim, Bilal; Kallidonis, Panagiotis; Petkova, Kremena; Guven, Selcuk; Kiremit, Murat Can; de Lorenzis, Elisa; Tefik, Tzevat; Villa, Luca; Zeng, Guohua; Sarica, Kemal title: How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE–IAU multicenter collaborative cohort study date: 2020-05-20 journal: Urolithiasis DOI: 10.1007/s00240-020-01193-8 sha: doc_id: 282361 cord_uid: gje78nb1 file: cache/cord-282589-xof56j98.json key: cord-282589-xof56j98 authors: Lopes, M. I. F.; Bonjorno, L. P.; Giannini, M. C.; Amaral, N. B.; Benatti, M. N.; Rezek, U. C.; Emrich-Filho, L. L.; Sousa, B. A.; Almeida, S. C.; Luppino-Assad, R.; Veras, F. P.; Schneider, A.; Rodrigues, T. S.; Leiria, L. O.; Cunha, L. D.; Alves-Filho, J. C.; Cunha, T. M.; Neto, E. A.; Miranda, C. H.; Pazin-Filho, A.; Martins, M. A.; Borges, M. C.; Fonseca, B. A.; Bollela, V. R.; Cunha, F. Q.; Zamboni, D. S.; Santana, R. C.; Vilar, F. C.; Louzada-Junior, P.; Oliveira, R. D. R. title: Beneficial effects of colchicine for moderate to severe COVID-19: an interim analysis of a randomized, double-blinded, placebo controlled clinical trial date: 2020-08-11 journal: nan DOI: 10.1101/2020.08.06.20169573 sha: doc_id: 282589 cord_uid: xof56j98 file: cache/cord-282660-9x937eus.json key: cord-282660-9x937eus authors: Muñoz Vives, Josep Maria; Jornet-Gibert, Montsant; Cámara-Cabrera, J.; Esteban, Pedro L.; Brunet, Laia; Delgado-Flores, Luis; Camacho-Carrasco, P.; Torner, P.; Marcano-Fernández, Francesc title: Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study date: 2020-05-06 journal: J Bone Joint Surg Am DOI: 10.2106/jbjs.20.00686 sha: doc_id: 282660 cord_uid: 9x937eus file: cache/cord-281804-lhnw8jx5.json key: cord-281804-lhnw8jx5 authors: Sonis, Jonathan D.; Kennedy, Maura; Aaronson, Emily L.; Baugh, Joshua J.; Raja, Ali S.; Yun, Bryan J.; White, Benjamin A. title: Humanism in the Age of COVID-19: Renewing Focus on Communication and Compassion date: 2020-04-24 journal: West J Emerg Med DOI: 10.5811/westjem.2020.4.47596 sha: doc_id: 281804 cord_uid: lhnw8jx5 file: cache/cord-282535-gnuhjs32.json key: cord-282535-gnuhjs32 authors: Cook, Gordon; Ashcroft, A John; Pratt, Guy; Popat, Rakesh; Ramasamy, Karthik; Kaiser, Martin; Jenner, Matthew; Henshaw, Sarah; Hall, Rachel; Sive, Jonathan; Stern, Simon; Streetly, Matthew; Bygrave, Ceri; Soutar, Richard; Rabin, Neil; Jackson, Graham H title: Real‐world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID‐19 disease) in patients with Multiple Myeloma receiving systemic anti‐cancer therapy. date: 2020-05-21 journal: Br J Haematol DOI: 10.1111/bjh.16874 sha: doc_id: 282535 cord_uid: gnuhjs32 file: cache/cord-282021-m1lh7mzd.json key: cord-282021-m1lh7mzd authors: El Shamy, Osama; Tran, Ha; Sharma, Shuchita; Ronco, Claudio; Narayanan, Mohanram; Uribarri, Jaime title: Telenephrology with Remote Peritoneal Dialysis Monitoring during Coronavirus Disease 19 date: 2020-04-28 journal: Am J Nephrol DOI: 10.1159/000508023 sha: doc_id: 282021 cord_uid: m1lh7mzd file: cache/cord-282430-u5ukqc5z.json key: cord-282430-u5ukqc5z authors: Fenton, Mark E.; Wasko, Kevin; Behl, Vern; Froh, John; Schmalenberg, Michelle title: An Expanded COVID-19 Telemedicine Intermediate Care Model Using Repurposed Hotel Rooms date: 2020-10-15 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202007-2902le sha: doc_id: 282430 cord_uid: u5ukqc5z file: cache/cord-282151-mai4eggf.json key: cord-282151-mai4eggf authors: Bai, Lu; Gu, Li; Cao, Bin; Zhai, Xiao-Li; Lu, Min; Lu, Yong; Liang, Li-Rong; Zhang, Lei; Gao, Zi-Fen; Huang, Ke-Wu; Liu, Ying-Mei; Song, Shu-Fan; Wu, Lin; Yin, Yu-Dong; Wang, Chen title: Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China date: 2015-12-16 journal: Chest DOI: 10.1378/chest.10-1036 sha: doc_id: 282151 cord_uid: mai4eggf file: cache/cord-282724-zzkqb0u2.json key: cord-282724-zzkqb0u2 authors: Moore, Jason H.; Barnett, Ian; Boland, Mary Regina; Chen, Yong; Demiris, George; Gonzalez-Hernandez, Graciela; Herman, Daniel S.; Himes, Blanca E.; Hubbard, Rebecca A.; Kim, Dokyoon; Morris, Jeffrey S.; Mowery, Danielle L.; Ritchie, Marylyn D.; Shen, Li; Urbanowicz, Ryan; Holmes, John H. title: Ideas for how informaticians can get involved with COVID-19 research date: 2020-05-12 journal: BioData Min DOI: 10.1186/s13040-020-00213-y sha: doc_id: 282724 cord_uid: zzkqb0u2 file: cache/cord-282704-qg2o0ug4.json key: cord-282704-qg2o0ug4 authors: Li, Xun; Wang, Luwen; Yan, Shaonan; Yang, Fan; Xiang, Longkui; Zhu, Jiling; Shen, Bo; Gong, Zuojiong title: Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China date: 2020-02-25 journal: nan DOI: 10.1101/2020.02.19.20025239 sha: doc_id: 282704 cord_uid: qg2o0ug4 file: cache/cord-282474-74273qgk.json key: cord-282474-74273qgk authors: Roehrig, Stefan; Ait Hssain, Ali; Shallik, Nabil Al Hamid; Elsaid, Ingi Mohamed A.; Mustafa, Salma Faisal; Smain, Osama A. M.; Molokhia, Ashraf Abdulla; Lance, Marcus D. title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-11 journal: Trials DOI: 10.1186/s13063-020-04708-1 sha: doc_id: 282474 cord_uid: 74273qgk file: cache/cord-282730-pawasfh4.json key: cord-282730-pawasfh4 authors: Contreras, Carlo M.; Metzger, Gregory A.; Beane, Joal D.; Dedhia, Priya H.; Ejaz, Aslam; Pawlik, Timothy M. title: Telemedicine: Patient-Provider Clinical Engagement During the COVID-19 Pandemic and Beyond date: 2020-05-08 journal: J Gastrointest Surg DOI: 10.1007/s11605-020-04623-5 sha: doc_id: 282730 cord_uid: pawasfh4 file: cache/cord-282610-zim7nond.json key: cord-282610-zim7nond authors: Proal, Amy; Marshall, Trevor title: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity date: 2018-12-04 journal: Front Pediatr DOI: 10.3389/fped.2018.00373 sha: doc_id: 282610 cord_uid: zim7nond file: cache/cord-282504-m3npy0om.json key: cord-282504-m3npy0om authors: Kastritis, Efstathios; Wechalekar, Ashutosh; Schönland, Stefan; Sanchorawala, Vaishali; Merlini, Giampaolo; Palladini, Giovanni; Minnema, Monique; Roussel, Murielle; Jaccard, Arnaud; Hegenbart, Ute; Kumar, Shaji; Cibeira, Maria Teresa; Blade, Joan; Dimopoulos, Meletios A. title: Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID‐19 pandemic date: 2020-06-01 journal: Br J Haematol DOI: 10.1111/bjh.16898 sha: doc_id: 282504 cord_uid: m3npy0om file: cache/cord-282963-p04c5nn7.json key: cord-282963-p04c5nn7 authors: Oliveros, Estefania; Mahmood, Kiran; Yammine, Maroun; Chau, Vinh; Fox, Arieh; Ahmed, Sanam; Anyanwu, Anelechi; Pinney, Sean; Mancini, Donna; Lala, Anuradha; Barghash, Maya title: Rapid Deterioration of Hospital-Acquired COVID-19 in a Patient on Extracorporeal Left Ventricular Assist Support date: 2020-09-21 journal: Heart Lung DOI: 10.1016/j.hrtlng.2020.08.021 sha: doc_id: 282963 cord_uid: p04c5nn7 file: cache/cord-283141-dh8j7lyl.json key: cord-283141-dh8j7lyl authors: Haskologlu, Sule; Kostel Bal, Sevgi; Islamoglu, Candan; Aytekin, Caner; Guner, Sukru; Sevinc, Selin; Keles, Sevgi; Kendirli, Tanil; Ceylaner, Serdar; Dogu, Figen; Ikinciogullari, Aydan title: Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency date: 2020-03-11 journal: Pediatr Allergy Immunol DOI: 10.1111/pai.13236 sha: doc_id: 283141 cord_uid: dh8j7lyl file: cache/cord-282780-34j7gquo.json key: cord-282780-34j7gquo authors: Lai, Kevin E.; Ko, Melissa W.; Rucker, Janet C.; Odel, Jeffrey G.; Sun, Linus D.; Winges, Kimberly M.; Ghosh, Arko; Bindiganavile, Shruthi Harish; Bhat, Nita; Wendt, Sydney P.; Scharf, Jackson M.; Dinkin, Marc J.; Rasool, Nailyn; Galetta, Steven L.; Lee, Andrew G. title: Tele-Neuro-Ophthalmology During the Age of COVID-19 date: 2020-06-26 journal: J Neuroophthalmol DOI: 10.1097/wno.0000000000001024 sha: doc_id: 282780 cord_uid: 34j7gquo file: cache/cord-282783-ps5jyjkl.json key: cord-282783-ps5jyjkl authors: nan title: Full Issue PDF date: 2020-09-30 journal: JACC: CardioOncology DOI: 10.1016/s2666-0873(20)30180-0 sha: doc_id: 282783 cord_uid: ps5jyjkl file: cache/cord-282956-f7if9e5q.json key: cord-282956-f7if9e5q authors: Yaghi, Shadi; Ishida, Koto; Torres, Jose; Mac Grory, Brian; Raz, Eytan; Humbert, Kelley; Henninger, Nils; Trivedi, Tushar; Lillemoe, Kaitlyn; Alam, Shazia; Sanger, Matthew; Kim, Sun; Scher, Erica; Dehkharghani, Seena; Wachs, Michael; Tanweer, Omar; Volpicelli, Frank; Bosworth, Brian; Lord, Aaron; Frontera, Jennifer title: SARS2-CoV-2 and Stroke in a New York Healthcare System date: 2020-05-26 journal: Stroke DOI: 10.1161/strokeaha.120.030335 sha: doc_id: 282956 cord_uid: f7if9e5q file: cache/cord-282867-kbyxdegu.json key: cord-282867-kbyxdegu authors: Shah, Sayed Zulfiqar Ali; Nasb, Mohammad; Lu, Min; Huang, Liangjiang; Wang, Yizhao; Chen, Hong title: Scaling the Need, Benefits, and Risks Associated with COVID-19 Acute and Postacute Care Rehabilitation: A Review date: 2020-08-26 journal: Rehabil Res Pract DOI: 10.1155/2020/3642143 sha: doc_id: 282867 cord_uid: kbyxdegu file: cache/cord-282912-jegpgqqi.json key: cord-282912-jegpgqqi authors: Pilato, Emanuele; Pinna, Giovanni Battista; Parisi, Valentina; Manzo, Rachele; Comentale, Giuseppe title: Mechanical complications of Myocardial Infarction during Covid-19 Pandemic: An Italian single-Centre experience: Heart ruptures in covid-19 era date: 2020-09-18 journal: Heart Lung DOI: 10.1016/j.hrtlng.2020.09.004 sha: doc_id: 282912 cord_uid: jegpgqqi file: cache/cord-283165-mdkr9qo0.json key: cord-283165-mdkr9qo0 authors: Russell, C.D.; Koch, O.; Laurenson, I.F.; O'Shea, D.T.; Sutherland, R.; Mackintosh, C.L. title: Diagnosis and features of hospital-acquired pneumonia: a retrospective cohort study date: 2015-12-15 journal: J Hosp Infect DOI: 10.1016/j.jhin.2015.11.013 sha: doc_id: 283165 cord_uid: mdkr9qo0 file: cache/cord-283738-v3h7p297.json key: cord-283738-v3h7p297 authors: Makar, Michael; John Pisano, Thomas; Minacapelli, Carlos D.; Rustgi, Vinod title: Gastrointestinal Findings in a Patient With COVID-19 date: 2020-06-11 journal: ACG Case Rep J DOI: 10.14309/crj.0000000000000392 sha: doc_id: 283738 cord_uid: v3h7p297 file: cache/cord-283215-dgysimh5.json key: cord-283215-dgysimh5 authors: Al-Jabir, Ahmed; Kerwan, Ahmed; Nicola, Maria; Alsafi, Zaid; Khan, Mehdi; Sohrabi, Catrin; O'Neill, Niamh; Iosifidis, Christos; Griffin, Michelle; Mathew, Ginimol; Agha, Riaz title: Impact of the coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation) date: 2020-05-12 journal: Int J Surg DOI: 10.1016/j.ijsu.2020.05.002 sha: doc_id: 283215 cord_uid: dgysimh5 file: cache/cord-283513-3f4rsgzm.json key: cord-283513-3f4rsgzm authors: Jaywant, Abhishek; Vanderlind, W. Michael; Boas, Samuel J.; Dickerman, Anna L. title: Behavioral interventions in acute COVID-19 recovery: A new opportunity for integrated care date: 2020-07-07 journal: Gen Hosp Psychiatry DOI: 10.1016/j.genhosppsych.2020.07.001 sha: doc_id: 283513 cord_uid: 3f4rsgzm file: cache/cord-283517-7gd0f06m.json key: cord-283517-7gd0f06m authors: Deak, Eszter; Marlowe, Elizabeth M. title: Right-Sizing Technology in the Era of Consumer-Driven Health Care date: 2017-08-01 journal: Clinical Microbiology Newsletter DOI: 10.1016/j.clinmicnews.2017.07.001 sha: doc_id: 283517 cord_uid: 7gd0f06m file: cache/cord-284163-3jmqzemf.json key: cord-284163-3jmqzemf authors: Seffer, Malin-Theres; Cottam, Daniel; Forni, Lui G.; Kielstein, Jan T. title: Heparin 2.0: A New Approach to the Infection Crisis date: 2020-07-02 journal: Blood Purif DOI: 10.1159/000508647 sha: doc_id: 284163 cord_uid: 3jmqzemf file: cache/cord-283583-pwlbrxn3.json key: cord-283583-pwlbrxn3 authors: Zhang, Xiao-Ai; Lu, Qing-Bin; Wo, Ying; Zhao, Jin; Huang, Dou-Dou; Guo, Chen-Tao; Xu, Hong-Mei; Liu, En-Mei; Liu, Wei; Cao, Wu-Chun title: Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012 date: 2015-01-09 journal: Sci Rep DOI: 10.1038/srep07704 sha: doc_id: 283583 cord_uid: pwlbrxn3 file: cache/cord-283779-mudwcypl.json key: cord-283779-mudwcypl authors: Lauretani, Fulvio; Ravazzoni, Giulia; Roberti, Maria Federica; Longobucco, Yari; Adorni, Elisa; Grossi, Margherita; De Iorio, Aurelio; La Porta, Umberto; Fazio, Chiara; Gallini, Elena; Federici, Raffaele; Salvi, Marco; Ciarrocchi, Erika; Rossi, Francesca; Bergamin, Marina; Bussolati, Giacomo; Grieco, Ilaria; Broccoli, Federica; Zucchini, Irene; Ielo, Giuseppe; Morganti, Simonetta; Artoni, Andrea; Arisi, Arianna; Tagliaferri, Sara; Maggio, Marcello title: Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications date: 2020-05-11 journal: Acta Biomed DOI: 10.23750/abm.v91i2.9629 sha: doc_id: 283779 cord_uid: mudwcypl file: cache/cord-283682-4fcyoyea.json key: cord-283682-4fcyoyea authors: Chan, Edward D.; Kalayanamit, Tul; Lynch, David A.; Tuder, Rubin; Arndt, Patrick; Winn, Robert; Schwarz, Marvin I. title: Mycoplasma pneumoniae-Associated Bronchiolitis Causing Severe Restrictive Lung Disease in Adults Report of Three Cases and Literature Review date: 1999-04-30 journal: Chest DOI: 10.1378/chest.115.4.1188 sha: doc_id: 283682 cord_uid: 4fcyoyea file: cache/cord-283267-72wrzw09.json key: cord-283267-72wrzw09 authors: Moores, Lisa K.; Tritschler, Tobias; Brosnahan, Shari; Carrier, Marc; Collen, Jacob F.; Doerschug, Kevin; Holley, Aaron B.; Jimenez, David; LeGal, Gregoire; Rali, Parth; Wells, Philip title: Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report date: 2020-06-02 journal: Chest DOI: 10.1016/j.chest.2020.05.559 sha: doc_id: 283267 cord_uid: 72wrzw09 file: cache/cord-283826-lgyc3sro.json key: cord-283826-lgyc3sro authors: Stiehm, E. Richard; Orange, Jordan S.; Ballow, Mark; Lehman, Heather title: Therapeutic Use of Immunoglobulins date: 2010-11-05 journal: Adv Pediatr DOI: 10.1016/j.yapd.2010.08.005 sha: doc_id: 283826 cord_uid: lgyc3sro file: cache/cord-284038-93s3ffoy.json key: cord-284038-93s3ffoy authors: Keyhanian, Kiandokht; Umeton, Raffaella Pizzolato; Mohit, Babak; Davoudi, Vahid; Hajighasemi, Fatemeh; Ghasemi, Mehdi title: SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation date: 2020-11-07 journal: J Neuroimmunol DOI: 10.1016/j.jneuroim.2020.577436 sha: doc_id: 284038 cord_uid: 93s3ffoy file: cache/cord-283719-zmizyx7e.json key: cord-283719-zmizyx7e authors: Cheng, Yuan-Yang; Chen, Chin-Ming; Huang, Wei-Chun; Chiang, Shang-Lin; Hsieh, Pei-Chun; Lin, Ko-Long; Chen, Yi-Jen; Fu, Tieh-Cheng; Huang, Shu-Chun; Chen, Ssu-Yuan; Chen, Chia-Hsin; Chen, Shyh-Ming; Chen, Hsin-Shui; Chou, Li-Wei; Chou, Chen-Liang; Li, Min-Hui; Tsai, Sen-Wei; Wang, Lin-Yi; Wang, Yu-Lin; Chou, Willy title: Rehabilitation Programs for Patients with COronaVIrus Disease 2019: Consensus Statements of Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation date: 2020-08-17 journal: J Formos Med Assoc DOI: 10.1016/j.jfma.2020.08.015 sha: doc_id: 283719 cord_uid: zmizyx7e file: cache/cord-284188-ujdla954.json key: cord-284188-ujdla954 authors: Smith, Silas W.; Tiu, Janelle; Caspers, Christopher G.; Lakdawala, Viraj S.; Koziatek, Christian A.; Swartz, Jordan L.; Lee, David C.; Jamin, Catherine T.; Femia, Robert J.; Haines, Elizabeth J. title: Virtual Urgent Care Quality and Safety in the Time of Coronavirus date: 2020-10-16 journal: Jt Comm J Qual Patient Saf DOI: 10.1016/j.jcjq.2020.10.001 sha: doc_id: 284188 cord_uid: ujdla954 file: cache/cord-283806-a6exd6dn.json key: cord-283806-a6exd6dn authors: Menardi, Endrj; Paolo Ballari, Gian; Racca, Emanuela; Gagliardi, Marco; Gonella, Anna; Sbarro, Francesca; Musso, Renata; Cagliero, Stella; Baralis, Giorgio title: Telemedicine during COVID‐19 pandemic date: 2020-05-30 journal: J Arrhythm DOI: 10.1002/joa3.12381 sha: doc_id: 283806 cord_uid: a6exd6dn file: cache/cord-284042-awl5bb0j.json key: cord-284042-awl5bb0j authors: Carrascosa, J.M.; Morillas, V.; Bielsa, I.; Munera-Campos, M. title: Cutaneous Manifestations in the Context of SARS-CoV-2 Infection (COVID-19)() date: 2020-10-15 journal: Actas Dermosifiliogr DOI: 10.1016/j.adengl.2020.10.001 sha: doc_id: 284042 cord_uid: awl5bb0j file: cache/cord-283231-ju71zm7w.json key: cord-283231-ju71zm7w authors: Yu, Juan; Zhang, Han-wen; Lei, Yi title: RE: Respiratory Infectious Disease in Resource Limited Setting: Radiology Management Advice date: 2020-04-15 journal: Acad Radiol DOI: 10.1016/j.acra.2020.03.020 sha: doc_id: 283231 cord_uid: ju71zm7w file: cache/cord-284387-cjziykrz.json key: cord-284387-cjziykrz authors: Garcia-Castrillo, Luis; Petrino, Roberta; Leach, Robert; Dodt, Christoph; Behringer, Wilhelm; Khoury, Abdo; Sabbe, Marc title: European Society For Emergency Medicine position paper on emergency medical systems’ response to COVID-19 date: 2020-05-04 journal: Eur J Emerg Med DOI: 10.1097/mej.0000000000000701 sha: doc_id: 284387 cord_uid: cjziykrz file: cache/cord-284365-g46myqe7.json key: cord-284365-g46myqe7 authors: Guo, Qian; Zheng, Yuchen; Shi, Jia; Wang, Jijun; Li, Guanjun; Li, Chunbo; Fromson, John A.; Xu, Yong; Liu, Xiaohua; Xu, Hua; Zhang, Tianhong; Lu, Yunfei; Chen, Xiaorong; Hu, Hao; Tang, Yingying; Yang, Shuwen; Zhou, Han; Wang, Xiaoliang; Chen, Haiying; Wang, Zhen; Yang, Zongguo title: Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study date: 2020-05-19 journal: Brain Behav Immun DOI: 10.1016/j.bbi.2020.05.038 sha: doc_id: 284365 cord_uid: g46myqe7 file: cache/cord-284298-tcied4l5.json key: cord-284298-tcied4l5 authors: Ojeahere, Margaret Isioma; de Filippis, Renato; Ransing, Ramdas; Karaliuniene, Ruta; Ullah, Irfan; Bytyçi, Drita Gashi; Abbass, Zargham; Kilic, Ozge; Nahidi, Mahsa; Hayatudeen, Nafisatu; Nagendrappa, Sachin; Shoib, Sheikh; Jatchavala, Chonnakarn; Larnaout, Amine; Maiti, Tanay; Ogunnubi, Oluseun Peter; El Hayek, Samer; Bizri, Maya; Schuh Teixeira, Andre Luiz; Pereira-Sanchez, Victor; Da Costa, Mariana Pinto title: Management of psychiatric conditions and delirium during the COVID-19 pandemic across continents: The lessons thus far date: 2020-09-19 journal: Brain Behav Immun Health DOI: 10.1016/j.bbih.2020.100147 sha: doc_id: 284298 cord_uid: tcied4l5 file: cache/cord-283969-wqrzaxsu.json key: cord-283969-wqrzaxsu authors: Antonucci, Michele; Recupero, Salvatore Marco; Marzio, Vittorio; De Dominicis, Mauro; Pinto, Francesco; Foschi, Nazario; Di Gianfrancesco, Luca; Bassi, Pierfrancesco; Ragonese, Mauro title: The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis date: 2020-10-28 journal: nan DOI: 10.1016/j.acuroe.2020.10.006 sha: doc_id: 283969 cord_uid: wqrzaxsu file: cache/cord-284454-malfatni.json key: cord-284454-malfatni authors: McCall, W. Travis title: Caring for Patients From a School Shooting: A Qualitative Case Series in Emergency Nursing date: 2020-08-19 journal: J Emerg Nurs DOI: 10.1016/j.jen.2020.06.005 sha: doc_id: 284454 cord_uid: malfatni file: cache/cord-284175-5rre1kbn.json key: cord-284175-5rre1kbn authors: Elsaid, Ossama; McCullough, Peter A.; Tecson, Kristen M.; Williams, Ryan S; Yoon, Anthony title: Ventricular Fibrillation Storm in Coronavirus 2019 date: 2020-08-29 journal: Am J Cardiol DOI: 10.1016/j.amjcard.2020.08.033 sha: doc_id: 284175 cord_uid: 5rre1kbn file: cache/cord-284545-vn60yd46.json key: cord-284545-vn60yd46 authors: Sanyaolu, Adekunle; Okorie, Chuku; Marinkovic, Aleksandra; Patidar, Risha; Younis, Kokab; Desai, Priyank; Hosein, Zaheeda; Padda, Inderbir; Mangat, Jasmine; Altaf, Mohsin title: Comorbidity and its Impact on Patients with COVID-19 date: 2020-06-25 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00363-4 sha: doc_id: 284545 cord_uid: vn60yd46 file: cache/cord-284332-p4c1fneh.json key: cord-284332-p4c1fneh authors: Bosma, Karen J.; Taneja, Ravi; Lewis, James F. title: Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date: 2012-09-19 journal: Drugs DOI: 10.2165/10898570-000000000-00000 sha: doc_id: 284332 cord_uid: p4c1fneh file: cache/cord-284526-a5kgo4ct.json key: cord-284526-a5kgo4ct authors: Gavriilaki, Eleni; Anyfanti, Panagiota; Gavriilaki, Maria; Lazaridis, Antonios; Douma, Stella; Gkaliagkousi, Eugenia title: Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses date: 2020-08-27 journal: Curr Hypertens Rep DOI: 10.1007/s11906-020-01078-6 sha: doc_id: 284526 cord_uid: a5kgo4ct file: cache/cord-284983-xvtkso79.json key: cord-284983-xvtkso79 authors: Vigiola Cruz, Mariana; Bellorin, Omar; Srivatana, Vesh; Afaneh, Cheguevara title: Safety and Efficacy of Bedside Peritoneal Dialysis Catheter Placement in the COVID-19 Era: Initial Experience at a New York City Hospital date: 2020-05-26 journal: World J Surg DOI: 10.1007/s00268-020-05600-4 sha: doc_id: 284983 cord_uid: xvtkso79 file: cache/cord-284251-brn5izwo.json key: cord-284251-brn5izwo authors: Melmed, Kara R.; Cao, Meng; Dogra, Siddhant; Zhang, Ruina; Yaghi, Shadi; Lewis, Ariane; Jain, Rajan; Bilaloglu, Seda; Chen, Ji; Czeisler, Barry M.; Raz, Eytan; Lord, Aaron; Berger, Jeffrey S.; Frontera, Jennifer A. title: Risk factors for intracerebral hemorrhage in patients with COVID-19 date: 2020-09-24 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02288-0 sha: doc_id: 284251 cord_uid: brn5izwo file: cache/cord-284979-lyt98od1.json key: cord-284979-lyt98od1 authors: Sia, Charmaine Si Min; Cheong, Samantha Hui Ling; Ngoh, Clara Lee Ying; Tan, Yi Hern; Wong, Weng Kin title: Critical Coronavirus Disease 2019 in a Hemodialysis Patient: A Proposed Clinical Management Strategy date: 2020-07-30 journal: Case Rep Nephrol Dial DOI: 10.1159/000509792 sha: doc_id: 284979 cord_uid: lyt98od1 file: cache/cord-285354-bp2dozzg.json key: cord-285354-bp2dozzg authors: Costanzi, Andrea; Mari, Giulio; Confalonieri, Marco; Maggioni, Dario; Fingerhut, Abe title: In response to: Surgery in the COVID-19 phase 2 Italian scenario: Lessons learned in Northern Italy spoke hospitals date: 2020-07-01 journal: J Trauma Acute Care Surg DOI: 10.1097/ta.0000000000002838 sha: doc_id: 285354 cord_uid: bp2dozzg file: cache/cord-285469-b61y9ezi.json key: cord-285469-b61y9ezi authors: Hernández-Fernández, Francisco; Valencia, Hernán Sandoval; Barbella-Aponte, Rosa Angélica; Collado-Jiménez, Rosa; Ayo-Martín, Óscar; Barrena, Cristina; Molina-Nuevo, Juan David; García-García, Jorge; Lozano-Setién, Elena; Alcahut-Rodriguez, Cristian; Martínez-Martín, Álvaro; Sánchez-López, Antonio; Segura, Tomás title: Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description date: 2020-07-09 journal: Brain DOI: 10.1093/brain/awaa239 sha: doc_id: 285469 cord_uid: b61y9ezi file: cache/cord-285472-cj5r3xt1.json key: cord-285472-cj5r3xt1 authors: Kaur, Parminder; Qaqa, Firas; Ramahi, Amr; Shamoon, Yezin; Singhal, Monisha; Shamoon, Fayez; Maroules, Michael; Singh, Balraj title: Acute upper limb ischemia in a patient with COVID-19 date: 2020-05-13 journal: Hematol Oncol Stem Cell Ther DOI: 10.1016/j.hemonc.2020.05.001 sha: doc_id: 285472 cord_uid: cj5r3xt1 file: cache/cord-285360-svczr721.json key: cord-285360-svczr721 authors: Ganesh, Aravind; Ospel, Johanna M.; Kromm, Julie; Goyal, Mayank title: Ignorance is not bliss: managing uncertainty in acute stroke treatment in the COVID-19 era date: 2020-10-31 journal: Neuroradiology DOI: 10.1007/s00234-020-02592-9 sha: doc_id: 285360 cord_uid: svczr721 file: cache/cord-284995-8lyr3gs4.json key: cord-284995-8lyr3gs4 authors: Fiorina, Laurent; Younsi, Salem; Horvilleur, Jérôme; Manenti, Vladimir; Lacotte, Jérôme; Raimondo, Cristina; Chemaly, Pascale; Salerno, Fiorella; Said, Mina Ait title: COVID-19 et troubles du rythme date: 2020-10-02 journal: Ann Cardiol Angeiol (Paris) DOI: 10.1016/j.ancard.2020.09.042 sha: doc_id: 284995 cord_uid: 8lyr3gs4 file: cache/cord-284576-nemh4wdo.json key: cord-284576-nemh4wdo authors: Sims, Jonathan T.; Krishnan, Venkatesh; Chang, Ching-Yun; Engle, Sarah M.; Casalini, Giacomo; Rodgers, George H.; Bivi, Nicoletta; Nickoloff, Brian J.; Konrad, Robert J.; de Bono, Stephanie; Higgs, Richard E.; Benschop, Robert J.; Ottaviani, Silvia; Cardoso, Anabela; Nirula, Ajay; Corbellino, Mario; Stebbing, Justin title: Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19 date: 2020-09-10 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.08.031 sha: doc_id: 284576 cord_uid: nemh4wdo file: cache/cord-285897-ahysay2l.json key: cord-285897-ahysay2l authors: Wu, Guangyao; Yang, Pei; Xie, Yuanliang; Woodruff, Henry C.; Rao, Xiangang; Guiot, Julien; Frix, Anne-Noelle; Louis, Renaud; Moutschen, Michel; Li, Jiawei; Li, Jing; Yan, Chenggong; Du, Dan; Zhao, Shengchao; Ding, Yi; Liu, Bin; Sun, Wenwu; Albarello, Fabrizio; D'Abramo, Alessandra; Schininà, Vincenzo; Nicastri, Emanuele; Occhipinti, Mariaelena; Barisione, Giovanni; Barisione, Emanuela; Halilaj, Iva; Lovinfosse, Pierre; Wang, Xiang; Wu, Jianlin; Lambin, Philippe title: Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study date: 2020-07-02 journal: Eur Respir J DOI: 10.1183/13993003.01104-2020 sha: doc_id: 285897 cord_uid: ahysay2l file: cache/cord-284804-6i5zbmm1.json key: cord-284804-6i5zbmm1 authors: Pan, Feng; Yang, Lian; Li, Yuncheng; Liang, Bo; Li, Lin; Ye, Tianhe; Li, Lingli; Liu, Dehan; Gui, Shan; Hu, Yu; Zheng, Chuansheng title: Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study date: 2020-05-18 journal: Int J Med Sci DOI: 10.7150/ijms.46614 sha: doc_id: 284804 cord_uid: 6i5zbmm1 file: cache/cord-284944-hcgfe9wv.json key: cord-284944-hcgfe9wv authors: Silvin, Aymeric; Chapuis, Nicolas; Dunsmore, Garett; Goubet, Anne-Gaëlle; Dubuisson, Agathe; Derosa, Lisa; Almire, Carole; Hénon, Clémence; Kosmider, Olivier; Droin, Nathalie; Rameau, Philippe; Catelain, Cyril; Alfaro, Alexia; Dussiau, Charles; Friedrich, Chloé; Sourdeau, Elise; Marin, Nathalie; Szwebel, Tali-Anne; Cantin, Delphine; Mouthon, Luc; Borderie, Didier; Deloger, Marc; Bredel, Delphine; Mouraud, Severine; Drubay, Damien; Andrieu, Muriel; Lhonneur, Anne-Sophie; Saada, Véronique; Stoclin, Annabelle; Willekens, Christophe; Pommeret, Fanny; Griscelli, Frank; Ng, Lai Guan; Zhang, Zheng; Bost, Pierre; Amit, Ido; Barlesi, Fabrice; Marabelle, Aurélien; Pène, Frédéric; Gachot, Bertrand; André, Fabrice; Zitvogel, Laurence; Ginhoux, Florent; Fontenay, Michaela; Solary, Eric title: Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19 date: 2020-08-05 journal: Cell DOI: 10.1016/j.cell.2020.08.002 sha: doc_id: 284944 cord_uid: hcgfe9wv file: cache/cord-285291-pep4opiq.json key: cord-285291-pep4opiq authors: Remy, Kenneth E.; Verhoef, Philip A.; Malone, Jay R.; Ruppe, Michael D.; Kaselitz, Timothy B.; Lodeserto, Frank; Hirshberg, Eliotte L.; Slonim, Anthony; Dezfulian, Cameron title: Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists* date: 2020-04-29 journal: Pediatr Crit Care Med DOI: 10.1097/pcc.0000000000002429 sha: doc_id: 285291 cord_uid: pep4opiq file: cache/cord-285818-eh12luma.json key: cord-285818-eh12luma authors: Louis, Shreya; Dhawan, Andrew; Newey, Christopher; Nair, Dileep; Jehi, Lara; Hantus, Stephen; Punia, Vineet title: Continuous Electroencephalography Characteristics and Acute Symptomatic Seizures in COVID-19 Patients date: 2020-08-26 journal: Clin Neurophysiol DOI: 10.1016/j.clinph.2020.08.003 sha: doc_id: 285818 cord_uid: eh12luma file: cache/cord-285414-vd2d7db2.json key: cord-285414-vd2d7db2 authors: Yu, Qian; Wang, Yuancheng; Huang, Shan; Liu, Songqiao; Zhou, Zhen; Zhang, Shijun; Zhao, Zhen; Yu, Yizhou; Yang, Yi; Ju, Shenghong title: Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients date: 2020-04-27 journal: Theranostics DOI: 10.7150/thno.46465 sha: doc_id: 285414 cord_uid: vd2d7db2 file: cache/cord-285467-uxfk6k3c.json key: cord-285467-uxfk6k3c authors: Ragni, Enrico; Mangiavini, Laura; Viganò, Marco; Brini, Anna Teresa; Peretti, Giuseppe Michele; Banfi, Giuseppe; de Girolamo, Laura title: Management of osteoarthritis during COVID‐19 pandemic date: 2020-05-21 journal: Clin Pharmacol Ther DOI: 10.1002/cpt.1910 sha: doc_id: 285467 cord_uid: uxfk6k3c file: cache/cord-284910-vjcrhwqz.json key: cord-284910-vjcrhwqz authors: Kirresh, Ali; Coghlan, Gerry; Candilio, Luciano title: COVID-19 infection and high intracoronary thrombus burden date: 2020-07-30 journal: Cardiovasc Revasc Med DOI: 10.1016/j.carrev.2020.07.032 sha: doc_id: 284910 cord_uid: vjcrhwqz file: cache/cord-285755-zblitbo0.json key: cord-285755-zblitbo0 authors: Zhang, F.; Yang, D.; Li, J.; Gao, P.; Chen, T.; Cheng, Z.; Cheng, K.; Fang, Q.; Pan, W.; Yi, C.; Fan, H.; Wu, Y.; Li, L.; Fang, Y.; Liu, J.; Tian, G.; He, L. title: Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study date: 2020-03-24 journal: nan DOI: 10.1101/2020.03.21.20040121 sha: doc_id: 285755 cord_uid: zblitbo0 file: cache/cord-285226-4ydvjmr3.json key: cord-285226-4ydvjmr3 authors: Sekhar, Laligam N.; Juric-Sekhar, Gordana; Qazi, Zeeshan; Patel, Anoop; McGrath, Lynn B.; Pridgeon, James; Kalavakonda, Niveditha; Hannaford, Blake title: The Future of Skull Base Surgery: A View Through Tinted Glasses date: 2020-06-27 journal: World Neurosurg DOI: 10.1016/j.wneu.2020.06.172 sha: doc_id: 285226 cord_uid: 4ydvjmr3 file: cache/cord-285757-fiqx4tll.json key: cord-285757-fiqx4tll authors: Mäkelä, M. J.; Halminen, M.; Ruuskanen, O.; Puhakka, T.; Pirhonen, J.; Julkunen, I.; Ilonen, J. title: Lack of Induction by Rhinoviruses of Systemic Type I Interferon Production or Enhanced MxA Protein Expression During the Common Cold date: 1999 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s100960050370 sha: doc_id: 285757 cord_uid: fiqx4tll file: cache/cord-285867-61y4aamj.json key: cord-285867-61y4aamj authors: Kichloo, Asim; Albosta, Michael Stanley; Jamal, Shakeel M.; Aljadah, Michael; Wani, Farah; Selene, Insija; Singh, Jagmeet; Taj, Asma title: Atezolizumab-Induced Bell’s Palsy in a Patient With Small Cell Lung Cancer date: 2020-10-13 journal: J Investig Med High Impact Case Rep DOI: 10.1177/2324709620965010 sha: doc_id: 285867 cord_uid: 61y4aamj file: cache/cord-285907-xoiju5ub.json key: cord-285907-xoiju5ub authors: Chang, Shang-Miao; Liu, Ching-Lung; Kuo, Hsu-Tah; Chen, Pei-Jan; Lee, Chun Ming; Lin, Fung-J.; Lin, Ching-Chi; Lee, Chao-Hsien; Lu, Yen-Ta title: Comparative study of patients with and without SARS WHO fulfilled the WHO SARS case definition date: 2005-05-31 journal: The Journal of Emergency Medicine DOI: 10.1016/j.jemermed.2004.11.022 sha: doc_id: 285907 cord_uid: xoiju5ub file: cache/cord-286227-foeb0g7u.json key: cord-286227-foeb0g7u authors: Potekaev, Nikolai N.; Zhukova, Olga V.; Protsenko, Denis N.; Demina, Olga M.; Khlystova, Elena A.; Bogin, Vlad title: Clinical characteristics of dermatologic manifestations of COVID‐19 infection: case series of 15 patients, review of literature, and proposed etiological classification date: 2020-07-03 journal: Int J Dermatol DOI: 10.1111/ijd.15030 sha: doc_id: 286227 cord_uid: foeb0g7u file: cache/cord-285588-ug7upa3r.json key: cord-285588-ug7upa3r authors: Ajibade, Ayomikun; Younas, Hiba; Pullan, Mark; Harky, Amer title: Telemedicine in cardiovascular surgery during COVID‐19 pandemic: A systematic review and our experience date: 2020-08-16 journal: J Card Surg DOI: 10.1111/jocs.14933 sha: doc_id: 285588 cord_uid: ug7upa3r file: cache/cord-285298-r7p44wpe.json key: cord-285298-r7p44wpe authors: Parsonage, William A.; Cullen, Louise; Brieger, David; Hillis, Graham S.; Nasis, Arthur; Dwyer, Nathan; Wahi, Sudhur; Lo, Sidney; Than, Martin; Kerr, Andrew; Devlin, Gerard; Chew, Derek K. title: CSANZ Position Statement on the Evaluation of Patients Presenting With Suspected Acute Coronary Syndromes During the COVID-19 Pandemic # date: 2020-05-21 journal: Heart Lung Circ DOI: 10.1016/j.hlc.2020.05.003 sha: doc_id: 285298 cord_uid: r7p44wpe file: cache/cord-286403-gdkwabcj.json key: cord-286403-gdkwabcj authors: Rosovsky, Rachel P.; Grodzin, Charles; Channick, Richard; Davis, George A.; Giri, Jay S.; Horowitz, James; Kabrhel, Christopher; Lookstein, Robert; Merli, Geno; Morris, Timothy A.; Rivera-Lebron, Belinda; Tapson, Victor; Todoran, Thomas M.; Weinberg, Aaron S.; Rosenfield, Kenneth title: Diagnosis and Treatment of Pulmonary Embolism During the COVID-19 Pandemic: A Position Paper from the National PERT Consortium date: 2020-08-27 journal: Chest DOI: 10.1016/j.chest.2020.08.2064 sha: doc_id: 286403 cord_uid: gdkwabcj file: cache/cord-286418-9ho5fg3h.json key: cord-286418-9ho5fg3h authors: Jenkins, Ian; Sebasky, Meghan; Bell, John; Horman, Sarah; Hong, Jonathan; Bouland, Dan; Seymann, FACP Greg title: Lessons from Walking the Medical Distancing Tightrope date: 2020-05-28 journal: Jt Comm J Qual Patient Saf DOI: 10.1016/j.jcjq.2020.05.006 sha: doc_id: 286418 cord_uid: 9ho5fg3h file: cache/cord-285732-xew5ar1e.json key: cord-285732-xew5ar1e authors: Eperjesiova, Bianka; Hart, Eric; Shokr, Mohamed; Sinha, Prabhat; Ferguson, Gary T title: Spontaneous Pneumomediastinum/Pneumothorax in Patients With COVID-19 date: 2020-07-03 journal: Cureus DOI: 10.7759/cureus.8996 sha: doc_id: 285732 cord_uid: xew5ar1e file: cache/cord-286096-h275nner.json key: cord-286096-h275nner authors: Huijskens, Elisabeth G. W.; van Erkel, Adriana J. M.; Palmen, Fernand M. H.; Buiting, Anton G. M.; Kluytmans, Jan A. J. W.; Rossen, John W. A. title: Viral and bacterial aetiology of community‐acquired pneumonia in adults date: 2012-08-22 journal: Influenza Other Respir Viruses DOI: 10.1111/j.1750-2659.2012.00425.x sha: doc_id: 286096 cord_uid: h275nner file: cache/cord-286638-bqxyb61p.json key: cord-286638-bqxyb61p authors: Singh, Awadhesh Kumar; Gupta, Ritesh; Ghosh, Amerta; Misra, Anoop title: Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations date: 2020-04-09 journal: Diabetes Metab Syndr DOI: 10.1016/j.dsx.2020.04.004 sha: doc_id: 286638 cord_uid: bqxyb61p file: cache/cord-286525-0354438s.json key: cord-286525-0354438s authors: Lee, Todd C.; Butler-Laporte, Guillaume; Chagla, Zain; McDonald, Emily G. title: Tocilizumab versus the covid19 tempest: all’s well that ends well or much ado about nothing? date: 2020-09-29 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2020.09.033 sha: doc_id: 286525 cord_uid: 0354438s file: cache/cord-286477-0euaaspo.json key: cord-286477-0euaaspo authors: Li, Xiaochen; Xu, Shuyun; Yu, Muqing; Wang, Ke; Tao, Yu; Zhou, Ying; Shi, Jing; Zhou, Min; Wu, Bo; Yang, Zhenyu; Zhang, Cong; Yue, Junqing; Zhang, Zhiguo; Renz, Harald; Liu, Xiansheng; Xie, Jungang; Xie, Min; Zhao, Jianping title: Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan date: 2020-04-12 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.04.006 sha: doc_id: 286477 cord_uid: 0euaaspo file: cache/cord-286237-x6dr6rsh.json key: cord-286237-x6dr6rsh authors: Maes, Bastiaan; Bosteels, Cedric; De Leeuw, Elisabeth; Declercq, Jozefien; Van Damme, Karel; Delporte, Anja; Demeyere, Bénédicte; Vermeersch, Stéfanie; Vuylsteke, Marnik; Willaert, Joren; Bollé, Laura; Vanbiervliet, Yuri; Decuypere, Jana; Libeer, Frederick; Vandecasteele, Stefaan; Peene, Isabelle; Lambrecht, Bart title: Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-03 journal: Trials DOI: 10.1186/s13063-020-04453-5 sha: doc_id: 286237 cord_uid: x6dr6rsh file: cache/cord-286574-t9z2ynt5.json key: cord-286574-t9z2ynt5 authors: nan title: Speaker presentations date: 2017-09-30 journal: International Journal of Antimicrobial Agents DOI: 10.1016/s0924-8579(17)30340-0 sha: doc_id: 286574 cord_uid: t9z2ynt5 file: cache/cord-286683-mettlmhz.json key: cord-286683-mettlmhz authors: Ortiz-Prado, Esteban; Simbaña-Rivera, Katherine; Gómez-Barreno, Lenin; Rubio-Neira, Mario; Guaman, Linda P.; Kyriakidis, Nikolaos C; Muslin, Claire; Jaramillo, Ana María Gómez; Barba-Ostria, Carlos; Cevallos-Robalino, Doménica; Sanches-SanMiguel, Hugo; Unigarro, Luis; Zalakeviciute, Rasa; Gadian, Naomi; López-Cortés, Andrés title: Clinical, molecular and epidemiological characterization of the SARS-CoV2 virus and the Coronavirus disease 2019 (COVID-19), a comprehensive literature review date: 2020-05-30 journal: Diagn Microbiol Infect Dis DOI: 10.1016/j.diagmicrobio.2020.115094 sha: doc_id: 286683 cord_uid: mettlmhz file: cache/cord-286743-z0e5arlm.json key: cord-286743-z0e5arlm authors: Langer-Gould, Annette; Smith, Jessica B.; Gonzales, Edlin G.; Castillo, Rhina D.; Garza Figueroa, Judith; Ramanathan, Anusha; Li, Bonnie H.; Gould, Michael K. title: Early Identification of COVID-19 Cytokine Storm and Treatment with Anakinra or Tocilizumab date: 2020-08-06 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.07.081 sha: doc_id: 286743 cord_uid: z0e5arlm file: cache/cord-287048-5od0ssyk.json key: cord-287048-5od0ssyk authors: Areaux, Raymond G.; de Alba Campomanes, Alejandra G.; Indaram, Maanasa; Shah, Ankoor S. title: Your eye doctor will virtually see you now: synchronous patient-to-provider virtual visits in pediatric tele-ophthalmology date: 2020-08-03 journal: J AAPOS DOI: 10.1016/j.jaapos.2020.06.004 sha: doc_id: 287048 cord_uid: 5od0ssyk file: cache/cord-287102-o19uwryp.json key: cord-287102-o19uwryp authors: Amit, Moran; Sorkin, Alex; Chen, Jacob; Cohen, Barak; Karol, Dana; Tsur, Avishai M; Lev, Shaul; Rozenblat, Tal; Dvir, Ayana; Landau, Geva; Fridrich, Lidar; Glassberg, Elon; Kesari, Shani; Sviri, Sigal; Gelman, Ram; Miller, Asaf; Epstein, Danny; Ben-Avi, Ronny; Matan, Moshe; Jakobson, Daniel J.; Bader, Tarif; Dahan, David; King, Daniel A.; Ben-Ari, Anat; Soroksky, Arie; Bar, Alon; Fink, Noam; Singer, Pierre; Benov, Avi title: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study date: 2020-07-18 journal: J Clin Med DOI: 10.3390/jcm9072282 sha: doc_id: 287102 cord_uid: o19uwryp file: cache/cord-285772-4xt4anq5.json key: cord-285772-4xt4anq5 authors: Huang, Rui; Zhu, Li; Xue, Leyang; Liu, Longgen; Yan, Xuebing; Wang, Jian; Zhang, Biao; Xu, Tianmin; Ji, Fang; Zhao, Yun; Cheng, Juan; Wang, Yinling; Shao, Huaping; Hong, Shuqin; Cao, Qi; Li, Chunyang; Zhao, Xiang-an; Zou, Lei; Sang, Dawen; Zhao, Haiyan; Guan, Xinying; Chen, Xiaobing; Shan, Chun; Xia, Juan; Chen, Yuxin; Yan, Xiaomin; Wei, Jie; Zhu, Chuanwu; Wu, Chao title: Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study date: 2020-05-08 journal: PLoS Negl Trop Dis DOI: 10.1371/journal.pntd.0008280 sha: doc_id: 285772 cord_uid: 4xt4anq5 file: cache/cord-286293-f5qg7vcz.json key: cord-286293-f5qg7vcz authors: Ullah, Waqas; Saeed, Rehan; Sarwar, Usman; Patel, Rajesh; Fischman, David L. title: COVID-19 complicated by Acute Pulmonary Embolism and Right-Sided Heart Failure date: 2020-04-17 journal: JACC Case Rep DOI: 10.1016/j.jaccas.2020.04.008 sha: doc_id: 286293 cord_uid: f5qg7vcz file: cache/cord-287117-3v9nyagt.json key: cord-287117-3v9nyagt authors: Monteagudo, Luke Adam; Boothby, Aaron; Gertner, Elie title: Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome date: 2020-04-21 journal: ACR Open Rheumatol DOI: 10.1002/acr2.11135 sha: doc_id: 287117 cord_uid: 3v9nyagt file: cache/cord-286611-e1i1wemo.json key: cord-286611-e1i1wemo authors: Benziger, Catherine P.; Huffman, Mark D.; Sweis, Ranya N.; Stone, Neil J. title: The Telehealth Ten: A Guide for a Patient-Assisted Virtual Physical Exam date: 2020-07-18 journal: Am J Med DOI: 10.1016/j.amjmed.2020.06.015 sha: doc_id: 286611 cord_uid: e1i1wemo file: cache/cord-286853-9gbel3pq.json key: cord-286853-9gbel3pq authors: Kim, Jiwon; Volodarskiy, Alexander; Sultana, Razia; Pollie, Meridith P.; Yum, Brian; Nambiar, Lakshmi; Tafreshi, Romina; Mitlak, Hannah W.; RoyChoudhury, Arindam; Horn, Evelyn M.; Hriljac, Ingrid; Narula, Nupoor; Kim, Sijun; Ndhlovu, Lishomwa; Goyal, Parag; Safford, Monika M.; Shaw, Leslee; Devereux, Richard B.; Weinsaft, Jonathan W. title: Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19 date: 2020-10-27 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2020.08.066 sha: doc_id: 286853 cord_uid: 9gbel3pq file: cache/cord-286843-8qh1pblc.json key: cord-286843-8qh1pblc authors: Quah, Jessica; Jiang, Boran; Tan, Poh Choo; Siau, Chuin; Tan, Thean Yen title: Impact of microbial Aetiology on mortality in severe community-acquired pneumonia date: 2018-09-04 journal: BMC Infect Dis DOI: 10.1186/s12879-018-3366-4 sha: doc_id: 286843 cord_uid: 8qh1pblc file: cache/cord-287515-oe7adj91.json key: cord-287515-oe7adj91 authors: Rello, Jordi; Tejada, Sofia; Userovici, Caroline; Arvaniti, Kostoula; Pugin, Jérôme; Waterer, Grant title: Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China date: 2020-03-03 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.03.001 sha: doc_id: 287515 cord_uid: oe7adj91 file: cache/cord-287468-e5h4tmy6.json key: cord-287468-e5h4tmy6 authors: Lopez, Alexandre; Duclos, Gary; Pastene, Bruno; Bezulier, Karine; Guilhaumou, Romain; Solas, Caroline; Zieleskiewicz, Laurent; Leone, Marc title: Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results date: 2020-08-08 journal: Int J Antimicrob Agents DOI: 10.1016/j.ijantimicag.2020.106136 sha: doc_id: 287468 cord_uid: e5h4tmy6 file: cache/cord-287373-7xjn05k8.json key: cord-287373-7xjn05k8 authors: Lian, Xin; Shen, Jing; Sun, Yuliang; Guan, Qiu; Pang, Tingtian; Yang, Zhiwei; He, Lei; Dong, Tingting; Shen, Jie; Zhang, Fuquan title: Under the coronavirus disease 2019(COVID-19) pandemic circumstance, how to administrate cancer patients with fever during radiotherapy date: 2020-06-05 journal: Radiother Oncol DOI: 10.1016/j.radonc.2020.05.049 sha: doc_id: 287373 cord_uid: 7xjn05k8 file: cache/cord-287222-wojyisu0.json key: cord-287222-wojyisu0 authors: Zhou, Min; Zhang, Xinxin; Qu, Jieming title: Coronavirus disease 2019 (COVID-19): a clinical update date: 2020-04-02 journal: Front Med DOI: 10.1007/s11684-020-0767-8 sha: doc_id: 287222 cord_uid: wojyisu0 file: cache/cord-287210-sars5dmi.json key: cord-287210-sars5dmi authors: Woo, Patrick C. Y.; Lau, Susanna K. P.; Tsoi, Hoi-wah; Huang, Yi; Poon, Rosana W. S.; Chu, Chung-ming; Lee, Rodney A.; Luk, Wei-kwang; Wong, Gilman K. M.; Wong, Beatrice H. L.; Cheng, Vincent C. C.; Tang, Bone S. F.; Wu, Alan K. L.; Yung, Raymond W. H.; Chen, Honglin; Guan, Yi; Chan, Kwok-hung; Yuen, Kwok-yung title: Clinical and Molecular Epidemiological Features of Coronavirus HKU1–Associated Community-Acquired Pneumonia date: 2005-12-01 journal: J Infect Dis DOI: 10.1086/497151 sha: doc_id: 287210 cord_uid: sars5dmi file: cache/cord-287367-1sdt9zz8.json key: cord-287367-1sdt9zz8 authors: Andrews, Denise; Chetty, Yumela; Cooper, Ben S.; Virk, Manjinder; Glass, Stephen K; Letters, Andrew; Kelly, Philip A.; Sudhanva, Malur; Jeyaratnam, Dakshika title: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use date: 2017-10-10 journal: BMC Infect Dis DOI: 10.1186/s12879-017-2784-z sha: doc_id: 287367 cord_uid: 1sdt9zz8 file: cache/cord-287508-133inel2.json key: cord-287508-133inel2 authors: Vasudevan, Rajiv S.; Horiuchi, Yu; Torriani, Francesca J.; Cotter, Bruno; Maisel, Sofie M.; Dadwal, Sanjeet S.; Gaynes, Robert; Maisel, Alan S. title: Persistent Value of the Stethoscope in the Age of COVID-19 date: 2020-06-19 journal: Am J Med DOI: 10.1016/j.amjmed.2020.05.018 sha: doc_id: 287508 cord_uid: 133inel2 file: cache/cord-287161-hqrql1lh.json key: cord-287161-hqrql1lh authors: McGrail, D. E.; Edwards, D. title: COVID-19 Case Series at UnityPoint Health St. Lukes Hospital in Cedar Rapids, IA date: 2020-07-19 journal: nan DOI: 10.1101/2020.07.17.20156521 sha: doc_id: 287161 cord_uid: hqrql1lh file: cache/cord-287520-51kmd2ds.json key: cord-287520-51kmd2ds authors: Carneiro, Arie; Wroclawski, Marcelo Langer; Nahar, Bruno; Soares, Andrey; Cardoso, Ana Paula; Kim, Nam Jin; Carvalho, Fabricio Torres title: Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date: 2020-05-20 journal: Int Braz J Urol DOI: 10.1590/s1677-5538.ibju.2020.04.03 sha: doc_id: 287520 cord_uid: 51kmd2ds file: cache/cord-286607-5i406twr.json key: cord-286607-5i406twr authors: Esposito, Susanna; Polinori, Ilaria; Rigante, Donato title: The Gut Microbiota-Host Partnership as a Potential Driver of Kawasaki Syndrome date: 2019-04-05 journal: Front Pediatr DOI: 10.3389/fped.2019.00124 sha: doc_id: 286607 cord_uid: 5i406twr file: cache/cord-287544-n32iscmr.json key: cord-287544-n32iscmr authors: Solaimanzadeh, Isaac title: Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19 date: 2020-05-12 journal: Cureus DOI: 10.7759/cureus.8069 sha: doc_id: 287544 cord_uid: n32iscmr file: cache/cord-287558-yc8aw2pg.json key: cord-287558-yc8aw2pg authors: Duffy, Eamon Y.; Cainzos-Achirica, Miguel; Michos, Erin D. title: Primary and Secondary Prevention of Cardiovascular Disease in the Era of the Coronavirus Pandemic date: 2020-04-20 journal: Circulation DOI: 10.1161/circulationaha.120.047194 sha: doc_id: 287558 cord_uid: yc8aw2pg file: cache/cord-287376-wxldnlih.json key: cord-287376-wxldnlih authors: Krüger, Colin M.; Kramer, Axel; Türler, Andreas; Riediger, Hartwig title: Can surgery follow the dictates of the pandemic “keep your distance”? Requirements with COVID-19 for hygiene, resources and the team date: 2020-08-03 journal: GMS Hyg Infect Control DOI: 10.3205/dgkh000354 sha: doc_id: 287376 cord_uid: wxldnlih file: cache/cord-287648-nhsn4cru.json key: cord-287648-nhsn4cru authors: Cameli, Matteo; Pastore, Maria Concetta; Soliman Aboumarie, Hatem; Mandoli, Giulia Elena; D'Ascenzi, Flavio; Cameli, Paolo; Bigio, Elisa; Franchi, Federico; Mondillo, Sergio; Valente, Serafina title: Usefulness of echocardiography to detect cardiac involvement in COVID‐19 patients date: 2020-07-12 journal: Echocardiography DOI: 10.1111/echo.14779 sha: doc_id: 287648 cord_uid: nhsn4cru file: cache/cord-287786-zfe0el8i.json key: cord-287786-zfe0el8i authors: Dudoignon, Emmanuel; Moreno, Nabila; Deniau, Benjamin; Coutrot, Maxime; Longer, Romain; Amiot, Quentin; Mebazaa, Alexandre; Pirracchio, Romain; Depret, François; Legrand, Matthieu title: Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19 date: 2020-06-18 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.06.006 sha: doc_id: 287786 cord_uid: zfe0el8i file: cache/cord-286334-d9v5xtx7.json key: cord-266105-8avkjc84 authors: Li, Qiang; Feng, Wei; Quan, Ying-Hui title: Trend and forecasting of the COVID-19 outbreak in China date: 2020-02-27 journal: J Infect DOI: 10.1016/j.jinf.2020.02.014 sha: doc_id: 266105 cord_uid: 8avkjc84 key: cord-286334-d9v5xtx7 authors: Li, Rui; Qiao, Songlin; Zhang, Gaiping title: Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date: 2020-04-30 journal: Journal of Infection DOI: 10.1016/j.jinf.2020.02.013 sha: doc_id: 286334 cord_uid: d9v5xtx7 file: cache/cord-287505-ihqzpdar.json key: cord-287505-ihqzpdar authors: Narain, Sonali; Stefanov, Dimitre G.; Chau, Alice S.; Weber, Andrew G.; Marder, Galina; Kaplan, Blanka; Malhotra, Prashant; Bloom, Ona; Liu, Audrey; Lesser, Martin L.; Hajizadeh, Negin; Cohen, Stuart L.; Cookingham, Jennifer; Hirschwerk, David A.; Maria, Naomi I.; Satapathy, Sanjaya K.; Sison, Cristina; Taylor, Matthew; Qiu, Michael title: Comparative Survival Analysis of Immunomodulatory Therapy for COVID-19 'Cytokine Storm' date: 2020-10-17 journal: Chest DOI: 10.1016/j.chest.2020.09.275 sha: doc_id: 287505 cord_uid: ihqzpdar file: cache/cord-287538-qbf5lv7d.json key: cord-287538-qbf5lv7d authors: Nucera, Eleonora; Aruanno, Arianna; Rizzi, Angela; Centrone, Michele title: Latex Allergy: Current Status and Future Perspectives date: 2020-09-28 journal: J Asthma Allergy DOI: 10.2147/jaa.s242058 sha: doc_id: 287538 cord_uid: qbf5lv7d file: cache/cord-287742-y1j9x5ne.json key: cord-287742-y1j9x5ne authors: Lee, Kai Wei; Yusof Khan, Abdul Hanif Khan; Ching, Siew Mooi; Chia, Peck Kee; Loh, Wei Chao; Abdul Rashid, Anna Misya'il; Baharin, Janudin; Inche Mat, Liyana Najwa; Wan Sulaiman, Wan Aliaa; Devaraj, Navin Kumar; Sivaratnam, Dhashani; Basri, Hamidon; Hoo, Fan Kee title: Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis date: 2020-10-06 journal: Front Neurol DOI: 10.3389/fneur.2020.579070 sha: doc_id: 287742 cord_uid: y1j9x5ne file: cache/cord-287497-93oiiqqi.json key: cord-287497-93oiiqqi authors: Tagliamento, Marco; Spagnolo, Francesco; Poggio, Francesca; Soldato, Davide; Conte, Benedetta; Ruelle, Tommaso; Barisione, Emanuela; De Maria, Andrea; Del Mastro, Lucia; Di Maio, Massimo; Lambertini, Matteo title: Italian survey on managing immune checkpoint inhibitors in oncology during COVID‐19 outbreak date: 2020-06-14 journal: Eur J Clin Invest DOI: 10.1111/eci.13315 sha: doc_id: 287497 cord_uid: 93oiiqqi file: cache/cord-287901-56goaqir.json key: cord-287901-56goaqir authors: Maudgil, D.D. title: Cost effectiveness and the role of the National Institute of Health and Care Excellence (NICE) in interventional radiology date: 2020-10-17 journal: Clin Radiol DOI: 10.1016/j.crad.2020.09.017 sha: doc_id: 287901 cord_uid: 56goaqir file: cache/cord-287765-nsdequl9.json key: cord-287765-nsdequl9 authors: Taiwo, Olutosin; Ezugwu, Absalom E. title: Smart healthcare support for remote patient monitoring during covid-19 quarantine date: 2020-09-15 journal: Inform Med Unlocked DOI: 10.1016/j.imu.2020.100428 sha: doc_id: 287765 cord_uid: nsdequl9 file: cache/cord-287957-diyz54qy.json key: cord-287957-diyz54qy authors: Deriba, Berhanu Senbeta; Geleta, Tinsae Abeya; Beyane, Rebik Shukure; Mohammed, Ahmed; Tesema, Mengistu; Jemal, Kemal title: Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities date: 2020-10-13 journal: Patient Prefer Adherence DOI: 10.2147/ppa.s276254 sha: doc_id: 287957 cord_uid: diyz54qy file: cache/cord-287874-wl0wlxh6.json key: cord-287874-wl0wlxh6 authors: Wang, Ling; Xu, Xiaopeng; Ruan, Junshan; Lin, Saijin; Jiang, Jinhua; Ye, Hong title: Quadruple therapy for asymptomatic COVID-19 infection patients date: 2020-05-03 journal: Expert Rev Anti Infect Ther DOI: 10.1080/14787210.2020.1758066 sha: doc_id: 287874 cord_uid: wl0wlxh6 file: cache/cord-288033-9xu1ujcq.json key: cord-288033-9xu1ujcq authors: Zeng, Jie; Huang, Jianxin; Pan, Lingai title: How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People’s Hospital date: 2020-03-11 journal: Intensive Care Med DOI: 10.1007/s00134-020-05993-9 sha: doc_id: 288033 cord_uid: 9xu1ujcq file: cache/cord-287732-abzpfdcu.json key: cord-287732-abzpfdcu authors: Martindale, Robert; Patel, Jayshil J.; Taylor, Beth; Arabi, Yaseen M.; Warren, Malissa; McClave, Stephen A. title: Nutrition Therapy in Critically Ill Patients with Coronavirus Disease (COVID‐19) date: 2020-05-27 journal: JPEN J Parenter Enteral Nutr DOI: 10.1002/jpen.1930 sha: doc_id: 287732 cord_uid: abzpfdcu file: cache/cord-287895-63wy5ztb.json key: cord-287895-63wy5ztb authors: Aponte Martín, Diego Mauricio; Corso, Claudia; Fuentes, Carlos; Aponte Aparicio, Maria Valentina; Sabbagh, Luis Carlos title: Use of a new face shield for patients of the endoscopy unit to avoid aerosol exchange in the COVID-19 era date: 2020-07-04 journal: VideoGIE DOI: 10.1016/j.vgie.2020.05.033 sha: doc_id: 287895 cord_uid: 63wy5ztb file: cache/cord-288158-6gicgsj8.json key: cord-288158-6gicgsj8 authors: Mahammedi, Abdelkader; Saba, Luca; Vagal, Achala; Leali, Michela; Rossi, Andrea; Gaskill, Mary; Sengupta, Soma; Zhang, Bin; Carriero, Alessandro; Bachir, Suha; Crivelli, Paola; Paschè, Alessio; Premi, Enrico; Padovani, Alessandro; Gasparotti, Roberto title: Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study date: 2020-05-21 journal: Radiology DOI: 10.1148/radiol.2020201933 sha: doc_id: 288158 cord_uid: 6gicgsj8 file: cache/cord-287953-prn8cnvo.json key: cord-287953-prn8cnvo authors: Shin, Nina; Kwag, Taewoo; Park, Sangwook; Kim, Yon Hui title: Effects of operational decisions on the diffusion of epidemic disease: A system dynamics modeling of the MERS-CoV outbreak in South Korea date: 2017-05-21 journal: Journal of Theoretical Biology DOI: 10.1016/j.jtbi.2017.03.020 sha: doc_id: 287953 cord_uid: prn8cnvo file: cache/cord-288040-uuqfvvmk.json key: cord-288040-uuqfvvmk authors: Kapoor, Saloni; Eldib, Amgad; Hiasat, Jamila; Scanga, Hannah; Tomasello, Jennifer; Alabek, Michelle; Ament, Kellie; Arner, Debbi; Benson, Ashley; Berret, Kristine; Blaha, Bianca; Brinza, Melissa; Caterino, Roxanne; Chauhan, Baresh; Churchfield, Whitney; Fulwylie, Christina; Gruszewski, Jessi; Hrinak, Denise; Johnston, Lori; Meyer, Cheryl; Nanda, Kaajal; Newton, Teresa; Pomycala, Becci; Runkel, Lauren; Sanchez, Katherine; Skellett, Sarah; Steigerwald, Jess; Mitchell, Ellen; Pihlblad, Matthew; Luchansky, Craig; Keim, Erin; Yu, Jenny; Quinn, Patrick; Mittal, Anshul; Pitetti, Raymond; Patil-Chhablani, Preeti; Liasis, Alkiviadis; Nischal, Ken K. title: Developing a pediatric ophthalmology telemedicine program in the COVID-19 crisis date: 2020-09-02 journal: J AAPOS DOI: 10.1016/j.jaapos.2020.05.008 sha: doc_id: 288040 cord_uid: uuqfvvmk file: cache/cord-288102-iom6lu7o.json key: cord-288102-iom6lu7o authors: Han, Jing; Shi, Li-xia; Xie, Yi; Zhang, Yong-jin; Huang, Shu-ping; Li, Jian-guo; Wang, He-rong; Shao, Shi-feng title: Analysis of factors affecting the prognosis of COVID-19 patients and viral shedding duration date: 2020-06-25 journal: Epidemiol Infect DOI: 10.1017/s0950268820001399 sha: doc_id: 288102 cord_uid: iom6lu7o file: cache/cord-288067-36amafub.json key: cord-288067-36amafub authors: Ashraf, Mohammad Ali; Shokouhi, Nasim; Shirali, Elham; Davari-tanha, Fateme; Memar, Omeed; Kamalipour, Alireza; Azarnoush, Ayein; Mabadi, Avin; Ossareh, Adele; Sanginabadi, Milad; Mokhtari Azad, Talat; Aghaghazvini, Leila; Ghaderkhani, Sara; Poordast, Tahereh; Pourdast, Alieh; Nazemi, Pershang title: COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes date: 2020-04-24 journal: nan DOI: 10.1101/2020.04.20.20072421 sha: doc_id: 288067 cord_uid: 36amafub file: cache/cord-287758-da11ypiy.json key: cord-287758-da11ypiy authors: Mônica Vitalino de Almeida, Sinara; Cleberson Santos Soares, José; Lima dos Santos, Keriolaine; Emanuel Ferreira Alves, Josival; Galdino Ribeiro, Amélia; Trindade Tenório Jacob, Íris; Juliane da Silva Ferreira, Cindy; Celerino dos Santos, Jéssica; Ferreira de Oliveira, Jamerson; Bezerra de Carvalho Junior, Luiz; do Carmo Alves de Lima, Maria title: COVID-19 therapy: what weapons do we bring into battle? date: 2020-09-10 journal: Bioorg Med Chem DOI: 10.1016/j.bmc.2020.115757 sha: doc_id: 287758 cord_uid: da11ypiy file: cache/cord-288222-8fqfbys2.json key: cord-288222-8fqfbys2 authors: Hardy, Michaël; Michaux, Isabelle; Lessire, Sarah; Douxfils, Jonathan; Dogné, Jean-Michel; Bareille, Marion; Horlait, Geoffrey; Bulpa, Pierre; Chapelle, Celine; Laporte, Silvy; Testa, Sophie; Jacqmin, Hugues; Lecompte, Thomas; Dive, Alain; Mullier, François title: Prothrombotic Disturbances of Hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Study date: 2020-10-24 journal: Thromb Res DOI: 10.1016/j.thromres.2020.10.025 sha: doc_id: 288222 cord_uid: 8fqfbys2 file: cache/cord-288009-8i3gsq9p.json key: cord-288009-8i3gsq9p authors: Javor, S.; Salsano, A. title: Why not consider an endothelin receptor antagonist against SARS‐CoV‐2? date: 2020-04-25 journal: Med Hypotheses DOI: 10.1016/j.mehy.2020.109792 sha: doc_id: 288009 cord_uid: 8i3gsq9p file: cache/cord-287991-10jz1dz2.json key: cord-287991-10jz1dz2 authors: Goshen-Lago, Tal; Szwarcwort-Cohen, Moran; Benguigui, Madeleine; Almog, Ronit; Turgeman, Ilit; Zaltzman, Nelly; Halberthal, Michael; Shaked, Yuval; Ben-Aharon, Irit title: The Potential Role of Immune Alteration in the Cancer–COVID19 Equation—A Prospective Longitudinal Study date: 2020-08-26 journal: Cancers (Basel) DOI: 10.3390/cancers12092421 sha: doc_id: 287991 cord_uid: 10jz1dz2 file: cache/cord-288271-p074ffpt.json key: cord-288271-p074ffpt authors: Mathies, D.; Rauschning, D.; Wagner, U.; Mueller, F.; Maibaum, M.; Binnemann, C.; Waldeck, S.; Thinnes, K.; Braun, M.; Schmidbauer, W.; Hagen, RM.; Bickel, C. title: A Case of SARS‐CoV‐2‐pneumonia with successful antiviral therapy in a 77‐year‐old male with heart transplant date: 2020-04-21 journal: Am J Transplant DOI: 10.1111/ajt.15932 sha: doc_id: 288271 cord_uid: p074ffpt file: cache/cord-288197-drto66xt.json key: cord-288197-drto66xt authors: Chen, Huijun; Guo, Juanjuan; Wang, Chen; Luo, Fan; Yu, Xuechen; Zhang, Wei; Li, Jiafu; Zhao, Dongchi; Xu, Dan; Gong, Qing; Liao, Jing; Yang, Huixia; Hou, Wei; Zhang, Yuanzhen title: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records date: 2020-02-12 journal: Lancet DOI: 10.1016/s0140-6736(20)30360-3 sha: doc_id: 288197 cord_uid: drto66xt file: cache/cord-288558-rthnj6wd.json key: cord-288558-rthnj6wd authors: Cheng, V. C. C.; Hung, I. F. N.; Tang, B. S. F.; Chu, C. M.; Wong, M. M. L.; Chan, K. H.; Wu, A. K. L.; Tse, D. M. W.; Chan, K. S.; Zheng, B. J.; Peiris, J. S. M.; Sung, J. J. Y.; Yuen, K. Y. title: Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome date: 2004-02-15 journal: Clin Infect Dis DOI: 10.1086/382681 sha: doc_id: 288558 cord_uid: rthnj6wd file: cache/cord-288580-onzzpkye.json key: cord-288580-onzzpkye authors: HALAÇLI, Burçin; KAYA, Akın; TOPELİ, Arzu title: Critically ill COVID-19 patient date: 2020-04-21 journal: Turk J Med Sci DOI: 10.3906/sag-2004-122 sha: doc_id: 288580 cord_uid: onzzpkye file: cache/cord-288181-9thl46oe.json key: cord-288181-9thl46oe authors: Fekkar, Arnaud; Poignon, Corentin; Blaize, Marion; Lampros, Alexandre title: Fungal Infection during COVID-19: Does Aspergillus Mean Secondary Invasive Aspergillosis? date: 2020-09-15 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202005-1945le sha: doc_id: 288181 cord_uid: 9thl46oe file: cache/cord-288371-uyj4iske.json key: cord-288371-uyj4iske authors: Arrieta, Oscar; Cardona, Andrés F.; Lara, Luis; Heredia, David; Barrón, Feliciano; Zatarain-Barrón, Zyanya Lucia; Lozano, Francisco; de Lima, Vladmir Cordeiro; Maldonado, Federico; Corona-Cruz, Francisco; Ramos, Maritza; Cabrera, Luis; Martin, Claudio; Corrales, Luis; Cuello, Mauricio; Arroyo-Hernández, Marisol; Aman, Enrique; Bacon, Ludwing; Baez, Renata; Benitez, Sergio; Botero, Antonio; Burotto, Mauricio; Caglevic, Christian; Ferraris, Gustavo; Freitas, Helano; Kaen, Diego Lucas; Lamot, Sebastián; Lyons, Gustavo; Mas, Luis; Mata, Andrea; Mathias, Clarissa; Muñoz, Alvaro; Patane, Ana Karina; Oblitas, George; Pino, Luis; Raez, Luis E.; Remon, Jordi; Rojas, Leonardo; Rolfo, Christian; Ruiz-Patiño, Alejandro; Samtani, Suraj; Viola, Lucia; Viteri, Santiago; Rosell, Rafael title: Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: The THOCOoP cooperative group date: 2020-06-20 journal: Crit Rev Oncol Hematol DOI: 10.1016/j.critrevonc.2020.103033 sha: doc_id: 288371 cord_uid: uyj4iske file: cache/cord-288051-wp8v2mc5.json key: cord-288051-wp8v2mc5 authors: Sánchez-González, Álvaro; López-Fando Lavalle, Luis; Esteban-Fernández, Alberto; Ruiz, Mercedes; Hevia, Vital; Comeche, Belén; Sánchez Conde, Matilde; Álvarez, Sara; Lorca Álvaro, Javier; Fraile Poblador, Agustín; Hevia Palacios, Manuel; Domínguez Gutiérrez, Ana; Artiles Medina, Alberto; Sanz Mayayo, Enrique; Duque, Gemma; Gómez Dos Santos, Victoria; Moreno-Guillén, Santiago; Burgos Revilla, Javier title: What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date: 2020-09-01 journal: Curr Urol Rep DOI: 10.1007/s11934-020-00995-y sha: doc_id: 288051 cord_uid: wp8v2mc5 file: cache/cord-288255-p8uzrsbd.json key: cord-288255-p8uzrsbd authors: Goossens, Gijs H.; Dicker, Dror; Farpour-Lambert, Nathalie J.; Frühbeck, Gema; Mullerova, Dana; Woodward, Euan; Holm, Jens-Christian title: Obesity and COVID-19: A Perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity date: 2020-08-13 journal: Obes Facts DOI: 10.1159/000510719 sha: doc_id: 288255 cord_uid: p8uzrsbd file: cache/cord-288697-9dywuhkc.json key: cord-288697-9dywuhkc authors: Noone, Rachel; Cabassa, Johanna A.; Gardner, Laura; Schwartz, Bruce; Alpert, Jonathan E.; Gabbay, Vilma title: LETTER TO THE EDITOR: NEW ONSET PSYCHOSIS AND MANIA FOLLOWING COVID-19 INFECTION date: 2020-08-08 journal: J Psychiatr Res DOI: 10.1016/j.jpsychires.2020.07.042 sha: doc_id: 288697 cord_uid: 9dywuhkc file: cache/cord-289006-7dv1zsp9.json key: cord-289006-7dv1zsp9 authors: Tan, Kimberly-Anne; Thadani, Vishaal Nanik; Chan, Daniel; Oh, Jacob Yoong-Leong; Liu, Gabriel Ka-Po title: Addressing Coronavirus Disease 2019 in Spine Surgery: A Rapid National Consensus Using the Delphi Method via Teleconference date: 2020-05-14 journal: Asian Spine J DOI: 10.31616/asj.2020.0224 sha: doc_id: 289006 cord_uid: 7dv1zsp9 file: cache/cord-288509-l6yn2er7.json key: cord-288509-l6yn2er7 authors: Kalu, Peter; Howgego, Gregory; Sharma, Ishta title: The rules for online clinical engagement in the COVID era date: 2020-08-22 journal: J Plast Reconstr Aesthet Surg DOI: 10.1016/j.bjps.2020.08.045 sha: doc_id: 288509 cord_uid: l6yn2er7 file: cache/cord-288790-5uzgenty.json key: cord-288790-5uzgenty authors: Govil, Gaurav; Tomar, Lavindra; Dhawan, Pawan title: Rehabilitation of Arthroplasty Patient During Covid-19 date: 2020-05-24 journal: Indian J Orthop DOI: 10.1007/s43465-020-00144-0 sha: doc_id: 288790 cord_uid: 5uzgenty file: cache/cord-289179-3zfur0zh.json key: cord-289179-3zfur0zh authors: Mascarin, Maurizio; Provenzi, Massimo; Coassin, Elisa; Franchin, Giovanni; Mariotto, Aldo title: How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients date: 2020-04-11 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.04.002 sha: doc_id: 289179 cord_uid: 3zfur0zh file: cache/cord-289064-435bp4rt.json key: cord-289064-435bp4rt authors: Muniangi-Muhitu, Hermine; Akalestou, Elina; Salem, Victoria; Misra, Shivani; Oliver, Nicholas S.; Rutter, Guy A. title: Covid-19 and Diabetes: A Complex Bidirectional Relationship date: 2020-10-08 journal: Front Endocrinol (Lausanne) DOI: 10.3389/fendo.2020.582936 sha: doc_id: 289064 cord_uid: 435bp4rt file: cache/cord-288575-srpc68t8.json key: cord-288575-srpc68t8 authors: Yamakage, Michiaki title: Anesthesia in the times of COVID-19 date: 2020-05-25 journal: J Anesth DOI: 10.1007/s00540-020-02798-4 sha: doc_id: 288575 cord_uid: srpc68t8 file: cache/cord-288606-h8pmqwmk.json key: cord-288606-h8pmqwmk authors: Alhmoud, Eman; Abdelsamad, Osama; Soaly, Ezeldin; Enany, Rasha El; Elewa, Hazem title: Anticoagulation clinic drive-up service during COVID-19 pandemic in Qatar date: 2020-07-03 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02206-4 sha: doc_id: 288606 cord_uid: h8pmqwmk file: cache/cord-288810-ab7k70c4.json key: cord-288810-ab7k70c4 authors: Zheng, Yingyan; Xiao, Anling; Yu, Xiangrong; Zhao, Yajing; Lu, Yiping; Li, Xuanxuan; Mei, Nan; She, Dejun; Wang, Dongdong; Geng, Daoying; Yin, Bo title: Development and Validation of a Prognostic Nomogram Based on Clinical and CT Features for Adverse Outcome Prediction in Patients with COVID-19 date: 2020-06-24 journal: Korean J Radiol DOI: 10.3348/kjr.2020.0485 sha: doc_id: 288810 cord_uid: ab7k70c4 file: cache/cord-289046-frhpt8n9.json key: cord-289046-frhpt8n9 authors: Fix, Oren K.; Serper, Marina title: Telemedicine and Telehepatology During the COVID‐19 Pandemic date: 2020-05-21 journal: Clin Liver Dis (Hoboken) DOI: 10.1002/cld.971 sha: doc_id: 289046 cord_uid: frhpt8n9 file: cache/cord-288552-7lp07v5i.json key: cord-288552-7lp07v5i authors: Vahedi, Ensieh; Ghanei, Mostafa; Ghazvini, Ali; Azadi, Hossein; Izadi, Morteza; Panahi, Yunes; Fathi, Saeid; Salesi, Mahmood; Saadat, Seyed Hassan; Ghazale, Amir Hossein; Rezapour, Mohammad; Mozafari, Abolfazl; Zand, Nahid; Parsaei, Mohammadreza Raesi; Ranjkesh, Mohammad Hossein; Jafari, Ramezan; Movaseghi, Fatemeh; Darabi, Enayat title: The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study date: 2020-06-19 journal: Daru DOI: 10.1007/s40199-020-00353-w sha: doc_id: 288552 cord_uid: 7lp07v5i file: cache/cord-289311-0wgafqdz.json key: cord-289311-0wgafqdz authors: Kim, Jee-Eun; Heo, Jae-Hyeok; Kim, Hye-ok; Song, Sook-hee; Park, Sang-Soon; Park, Tai-Hwan; Ahn, Jin-Young; Kim, Min-Ky; Choi, Jae-Phil title: Neurological Complications during Treatment of Middle East Respiratory Syndrome date: 2017-06-30 journal: J Clin Neurol DOI: 10.3988/jcn.2017.13.3.227 sha: doc_id: 289311 cord_uid: 0wgafqdz file: cache/cord-289542-u86ujtur.json key: cord-289542-u86ujtur authors: Razavian, Narges; Major, Vincent J.; Sudarshan, Mukund; Burk-Rafel, Jesse; Stella, Peter; Randhawa, Hardev; Bilaloglu, Seda; Chen, Ji; Nguy, Vuthy; Wang, Walter; Zhang, Hao; Reinstein, Ilan; Kudlowitz, David; Zenger, Cameron; Cao, Meng; Zhang, Ruina; Dogra, Siddhant; Harish, Keerthi B.; Bosworth, Brian; Francois, Fritz; Horwitz, Leora I.; Ranganath, Rajesh; Austrian, Jonathan; Aphinyanaphongs, Yindalon title: A validated, real-time prediction model for favorable outcomes in hospitalized COVID-19 patients date: 2020-10-06 journal: NPJ Digit Med DOI: 10.1038/s41746-020-00343-x sha: doc_id: 289542 cord_uid: u86ujtur file: cache/cord-289054-fh95b5n4.json key: cord-289054-fh95b5n4 authors: Au Yong, Phui S.; Chen, Xuanxuan title: Reducing droplet spread during airway manipulation: lessons from the COVID-19 pandemic in Singapore date: 2020-04-15 journal: Br J Anaesth DOI: 10.1016/j.bja.2020.04.007 sha: doc_id: 289054 cord_uid: fh95b5n4 file: cache/cord-289115-bntcn0m6.json key: cord-289115-bntcn0m6 authors: Thangaraju, Pugazhenthan; Venkatesan, Nanditha; Sudha, T. Y. Sree; Venkatesan, Sajitha; Thangaraju, Eswaran title: Role of Dupilumab in Approved Indications of COVID-19 Patient: an Efficacy-Based Nonsystematic Critical Analysis date: 2020-09-10 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00510-x sha: doc_id: 289115 cord_uid: bntcn0m6 file: cache/cord-289219-qjxdggz3.json key: cord-289219-qjxdggz3 authors: Sebio-García, Raquel title: Pulmonary Rehabilitation: Time for an Upgrade date: 2020-08-25 journal: J Clin Med DOI: 10.3390/jcm9092742 sha: doc_id: 289219 cord_uid: qjxdggz3 file: cache/cord-289457-06gwrpu0.json key: cord-289457-06gwrpu0 authors: Berth, Sarah H.; Lloyd, Thomas E. title: Secondary Causes of Myositis date: 2020-10-06 journal: Curr Treat Options Neurol DOI: 10.1007/s11940-020-00646-0 sha: doc_id: 289457 cord_uid: 06gwrpu0 file: cache/cord-289690-af6lsj1g.json key: cord-289690-af6lsj1g authors: Svobodova, Tamara; Mejstrikova, Ester; Salzer, Ulrich; Sukova, Martina; Hubacek, Petr; Matej, Radoslav; Vasakova, Martina; Hornofova, Ludmila; Dvorakova, Marcela; Fronkova, Eva; Votava, Felix; Freiberger, Tomas; Pohunek, Petr; Stary, Jan; Janda, Ales title: Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date: 2015-02-10 journal: BMC Pulm Med DOI: 10.1186/s12890-015-0006-2 sha: doc_id: 289690 cord_uid: af6lsj1g file: cache/cord-289719-64ugdvfe.json key: cord-289719-64ugdvfe authors: Tenforde, Mark W.; Billig Rose, Erica; Lindsell, Christopher J.; Shapiro, Nathan I.; Files, D. Clark; Gibbs, Kevin W.; Prekker, Matthew E.; Steingrub, Jay S.; Smithline, Howard A.; Gong, Michelle N.; Aboodi, Michael S.; Exline, Matthew C.; Henning, Daniel J.; Wilson, Jennifer G.; Khan, Akram; Qadir, Nida; Stubblefield, William B.; Patel, Manish M.; Self, Wesley H.; Feldstein, Leora R.; Kassem, Ahmed M.; Sciarratta, Courtney N.; Dzuris, Nicole; Marcet, Paula L.; Siddula, Akshita; Griggs, Eric P.; Smith, Emily R.; Ogokeh, Constance E.; Wu, Michael; Kim, Sara S. title: Characteristics of Adult Outpatients and Inpatients with COVID-19 — 11 Academic Medical Centers, United States, March–May 2020 date: 2020-07-03 journal: MMWR Morb Mortal Wkly Rep DOI: 10.15585/mmwr.mm6926e3 sha: doc_id: 289719 cord_uid: 64ugdvfe file: cache/cord-289088-7uoia564.json key: cord-289088-7uoia564 authors: Ding, Qiang; Lu, Panpan; Fan, Yuhui; Xia, Yujia; Liu, Mei title: The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China date: 2020-03-30 journal: J Med Virol DOI: 10.1002/jmv.25781 sha: doc_id: 289088 cord_uid: 7uoia564 file: cache/cord-289322-5ciaonf0.json key: cord-289322-5ciaonf0 authors: Chen, X.; Zheng, F.; Qing, Y.; Ding, S.; Yang, D.; Lei, C.; Yin, Z.; Zhou, X.; Jiang, D.; Zuo, Q.; He, J.; Lv, J.; Chen, P.; Chen, Y.; Peng, H.; Li, H.; Xie, Y.; Liu, J.; Zhou, Z.; Luo, H. title: Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study date: 2020-03-06 journal: nan DOI: 10.1101/2020.03.03.20030353 sha: doc_id: 289322 cord_uid: 5ciaonf0 file: cache/cord-289008-c4cu3vrp.json key: cord-289008-c4cu3vrp authors: Wallis, Christopher J.D.; Novara, Giacomo; Marandino, Laura; Bex, Axel; Kamat, Ashish M.; Karnes, R. Jeffrey; Morgan, Todd M.; Mottet, Nicolas; Gillessen, Silke; Bossi, Alberto; Roupret, Morgan; Powles, Thomas; Necchi, Andrea; Catto, James W.F.; Klaassen, Zachary title: Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic date: 2020-05-03 journal: Eur Urol DOI: 10.1016/j.eururo.2020.04.063 sha: doc_id: 289008 cord_uid: c4cu3vrp file: cache/cord-289574-engwi8h3.json key: cord-289574-engwi8h3 authors: An, Peng-jiao; Yi, Zhun Zhu; Yang, Li-ping title: Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications date: 2020-05-23 journal: Pharmacol Res DOI: 10.1016/j.phrs.2020.104946 sha: doc_id: 289574 cord_uid: engwi8h3 file: cache/cord-290006-63sa00ju.json key: cord-290006-63sa00ju authors: Ko, Jane P.; Girvin, Francis; Moore, William; Naidich, David P. title: Approach to Peribronchovascular Disease on CT date: 2018-12-20 journal: Semin Ultrasound CT MR DOI: 10.1053/j.sult.2018.12.002 sha: doc_id: 290006 cord_uid: 63sa00ju file: cache/cord-289581-aozg3o9o.json key: cord-289581-aozg3o9o authors: nan title: Abstracts der 54. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date: 2016-08-25 journal: Monatsschr Kinderheilkd DOI: 10.1007/s00112-016-0156-1 sha: doc_id: 289581 cord_uid: aozg3o9o file: cache/cord-289169-3u7qgxud.json key: cord-289169-3u7qgxud authors: Fang, Xiaowei; Mei, Qing; Yang, Tianjun; Li, Lei; Wang, Yinzhong; Tong, Fei; Geng, Shike; Pan, Aijun title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 date: 2020-04-11 journal: J Infect DOI: 10.1016/j.jinf.2020.03.039 sha: doc_id: 289169 cord_uid: 3u7qgxud file: cache/cord-289816-rlwoy8ms.json key: cord-289816-rlwoy8ms authors: Tedeschi, Delio; Rizzi, Andrea; Biscaglia, Simone; Tumscitz, Carlo title: Acute myocardial infarction and large coronary thrombosis in a patient with COVID‐19 date: 2020-08-07 journal: Catheter Cardiovasc Interv DOI: 10.1002/ccd.29179 sha: doc_id: 289816 cord_uid: rlwoy8ms file: cache/cord-289553-gygvhzcc.json key: cord-289553-gygvhzcc authors: Alvarez, Roger A.; Berra, Lorenzo; Gladwin, Mark T. title: Home Nitric Oxide Therapy for COVID-19 date: 2020-07-01 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202005-1906ed sha: doc_id: 289553 cord_uid: gygvhzcc file: cache/cord-289859-b1k9uyp6.json key: cord-289859-b1k9uyp6 authors: Hodges, Kevin; Mubashir, Mujtaba; Insler, Joshua; Estep, Jerry; Hsich, Eileen; Tong, Michael; Insler, Steven; Soltesz, Edward title: Successful management of COVID‐19 and associated coagulopathy in a patient with durable left ventricular assist device date: 2020-08-13 journal: J Card Surg DOI: 10.1111/jocs.14937 sha: doc_id: 289859 cord_uid: b1k9uyp6 file: cache/cord-289930-7xm6q68s.json key: cord-289930-7xm6q68s authors: Li, Yang; Zhou, Xian; Li, Tao; Chan, Shiji; Yu, Yiqi; Ai, Jing-Wen; Zhang, Haocheng; Sun, Feng; Zhang, Qiran; Zhu, Lei; Shao, Lingyun; Xu, Bin; Zhang, Wenhong title: Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational study date: 2020-08-21 journal: Emerging microbes & infections DOI: 10.1080/22221751.2020.1807885 sha: doc_id: 289930 cord_uid: 7xm6q68s file: cache/cord-289114-ifnk41oq.json key: cord-289114-ifnk41oq authors: Singh, Angaraj; Kumar, Manoj; Dubey, Ashutosh Kumar title: Effect of pre‐existing diseases on COVID‐19 infection and role of new sensors and biomaterials for its detection and treatment date: 2020-10-28 journal: Med Devices Sens DOI: 10.1002/mds3.10140 sha: doc_id: 289114 cord_uid: ifnk41oq file: cache/cord-289533-hip9qtu5.json key: cord-289533-hip9qtu5 authors: Smulever, Anabella; Abelleira, Erika; Bueno, Fernanda; Pitoia, Fabián title: Thyroid cancer in the Era of COVID-19 date: 2020-08-04 journal: Endocrine DOI: 10.1007/s12020-020-02439-6 sha: doc_id: 289533 cord_uid: hip9qtu5 file: cache/cord-289806-6ihptx6n.json key: cord-289806-6ihptx6n authors: Martinez, Rebecca; Bernstein, Kyra; Ring, Laurence; Ona, Samsiya; Baptiste, Caitlin; Syeda, Sbaa; Aziz, Aleha; Robinson, Kenya; Valderrama, Natali; Sheen, Jean-Ju; D’Alton, Mary; Goffman, Dena; Gyamfi-Bannerman, Cynthia; Moroz, Leslie; Landau, Ruth title: Critical Obstetric Patients During the Coronavirus Disease 2019 Pandemic: Operationalizing an Obstetric Intensive Care Unit date: 2020-10-07 journal: Anesth Analg DOI: 10.1213/ane.0000000000005253 sha: doc_id: 289806 cord_uid: 6ihptx6n file: cache/cord-289854-p8okfa4b.json key: cord-289854-p8okfa4b authors: Flores, Gabriel; Kumar, Jay I; Pressman, Elliot; Sack, Jayson; Alikhani, Puya title: Spontaneous Brainstem Hemorrhagic Stroke in the Setting of Novel Coronavirus Disease 2019 – A Case Report date: 2020-10-05 journal: Cureus DOI: 10.7759/cureus.10809 sha: doc_id: 289854 cord_uid: p8okfa4b file: cache/cord-290041-zxlq63n5.json key: cord-290041-zxlq63n5 authors: Srivastava, Arnav; Patel, Hiren V.; Kim, Sinae; Shinder, Brian; Sterling, Joshua; Tabakin, Alexandra L.; Polotti, Charles F.; Saraiya, Biren; Mayer, Tina; Kim, Isaac Y.; Ghodoussipour, Saum; Patel, Hiten D.; Jang, Thomas L.; Singer, Eric A. title: Delaying Surgery for Clinical T1b-T2bN0M0 Renal Cell Carcinoma: Oncologic Implications in the COVID-19 Era and Beyond date: 2020-10-20 journal: Urol Oncol DOI: 10.1016/j.urolonc.2020.10.012 sha: doc_id: 290041 cord_uid: zxlq63n5 file: cache/cord-289775-40bi87iz.json key: cord-289775-40bi87iz authors: Haines, David E.; Beheiry, Salwa; Akar, Joseph G.; Baker, Janice L.; Beinborn, Doug; Beshai, John F.; Brysiewicz, Neil; Chiu-Man, Christine; Collins, Kathryn K.; Dare, Matthew; Fetterly, Kenneth; Fisher, John D.; Hongo, Richard; Irefin, Samuel; Lopez, John; Miller, John M.; Perry, James C.; Slotwiner, David J.; Tomassoni, Gery F.; Weiss, Esther title: Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety date: 2014-05-07 journal: Heart Rhythm DOI: 10.1016/j.hrthm.2014.03.042 sha: doc_id: 289775 cord_uid: 40bi87iz file: cache/cord-289828-3k088z9n.json key: cord-289828-3k088z9n authors: De Salvo, Andrea; Amicucci, Matteo; Ciaralli, Italo; Secco, Domitilla; Miele, Evelina; Bevilacqua, Francesca; Milano, Giuseppe Maria title: How to be together and carry on our project activities during COVID‐19 pandemic in Rome date: 2020-08-03 journal: Pediatr Blood Cancer DOI: 10.1002/pbc.28431 sha: doc_id: 289828 cord_uid: 3k088z9n file: cache/cord-290028-oyd7vzj6.json key: cord-290028-oyd7vzj6 authors: Unruh, Mark; Cukor, Daniel; Rue, Tessa; Abad, Kashif; Roumelioti, Maria-Eleni; McCurry, Susan M.; Heagerty, Patrick; Mehrotra, Rajnish title: Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis date: 2020-10-20 journal: BMC Nephrol DOI: 10.1186/s12882-020-02107-x sha: doc_id: 290028 cord_uid: oyd7vzj6 file: cache/cord-289612-4x5t4c5u.json key: cord-289612-4x5t4c5u authors: Alsuliman, Tamim; Sulaiman, Rand; Ismail, Sawsan; Srour, Micha; Alrstom, Ali title: COVID-19 paraclinical diagnostic tools: Updates and future trends date: 2020-06-20 journal: Curr Res Transl Med DOI: 10.1016/j.retram.2020.06.001 sha: doc_id: 289612 cord_uid: 4x5t4c5u file: cache/cord-289973-1mczuxsy.json key: cord-289973-1mczuxsy authors: Biran, Noa; Ip, Andrew; Ahn, Jaeil; Go, Ronaldo C; Wang, Shuqi; Mathura, Shivam; Sinclaire, Brittany A; Bednarz, Urszula; Marafelias, Michael; Hansen, Eric; Siegel, David S; Goy, Andre H; Pecora, Andrew L; Sawczuk, Ihor S; Koniaris, Lauren S; Simwenyi, Micky; Varga, Daniel W; Tank, Lisa K; Stein, Aaron A; Allusson, Valerie; Lin, George S; Oser, William F; Tuma, Roman A; Reichman, Joseph; Brusco, Louis; Carpenter, Kim L; Costanzo, Eric J; Vivona, Vincent; Goldberg, Stuart L title: Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study date: 2020-08-14 journal: The Lancet Rheumatology DOI: 10.1016/s2665-9913(20)30277-0 sha: doc_id: 289973 cord_uid: 1mczuxsy file: cache/cord-290081-pjg00t7g.json key: cord-290081-pjg00t7g authors: Dunkerley, Sarah; Thelwall, Claire; Omiawele, Joshua; Smith, Adam; Deo, Sunny; Lowdon, Ian title: Patient care modifications and hospital regulations during the COVID-19 crisis created inequality and functional hazard for patients with orthopaedic trauma date: 2020-08-07 journal: Int Orthop DOI: 10.1007/s00264-020-04764-x sha: doc_id: 290081 cord_uid: pjg00t7g file: cache/cord-290200-csmisulw.json key: cord-290200-csmisulw authors: Friedlaender, Alex; Kim, Chul; Addeo, Alfredo title: Rethinking the Optimal Duration of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer Throughout the COVID-19 Pandemic date: 2020-05-12 journal: Front Oncol DOI: 10.3389/fonc.2020.00862 sha: doc_id: 290200 cord_uid: csmisulw file: cache/cord-290551-a02tueuu.json key: cord-290551-a02tueuu authors: Singh, Shailendra; Bilal, Mohammad; Pakhchanian, Haig; Raiker, Rahul; Kochhar, Gursimran S.; Thompson, Christopher C. title: Impact of Obesity on Outcomes of Patients with COVID-19 in United States: A Multicenter Electronic Health Records Network Study. date: 2020-08-21 journal: Gastroenterology DOI: 10.1053/j.gastro.2020.08.028 sha: doc_id: 290551 cord_uid: a02tueuu file: cache/cord-290065-ouua7wnq.json key: cord-290065-ouua7wnq authors: Kashi, Mahine; Jacquin, Aurélien; Dakhil, Bassel; Zaimi, Rym; Mahé, Emmanuel; Tella, Emilie; Bagan, Patrick title: Severe arterial thrombosis associated with Covid-19 infection date: 2020-05-16 journal: Thromb Res DOI: 10.1016/j.thromres.2020.05.025 sha: doc_id: 290065 cord_uid: ouua7wnq file: cache/cord-290267-ke696q8j.json key: cord-290267-ke696q8j authors: Fang, Huilin; Liu, Qiaomei; Xi, Maomao; Xiong, Di; He, Jing; Luo, Pengcheng; Li, Zhanghua title: Impact of comorbidities on clinical prognosis in 1280 patients with different types of COVID-19 date: 2020-10-13 journal: J Investig Med DOI: 10.1136/jim-2020-001555 sha: doc_id: 290267 cord_uid: ke696q8j file: cache/cord-290401-t87i3exo.json key: cord-290401-t87i3exo authors: Bassetti, Matteo; Kollef, Marin H.; Poulakou, Garyphallia title: Principles of antimicrobial stewardship for bacterial and fungal infections in ICU date: 2017-09-12 journal: Intensive Care Med DOI: 10.1007/s00134-017-4922-x sha: doc_id: 290401 cord_uid: t87i3exo file: cache/cord-290295-gl144dh9.json key: cord-290295-gl144dh9 authors: Martínez-López, Joaquín; Mateos, María-Victoria; Encinas, Cristina; Sureda, Anna; Hernández-Rivas, José Ángel; Lopez de la Guía, Ana; Conde, Diego; Krsnik, Isabel; Prieto, Elena; Riaza Grau, Rosalía; Gironella, Mercedes; Blanchard, María Jesús; Caminos, Nerea; Fernández de Larrea, Carlos; Senin, María Alicia; Escalante, Fernando; de la Puerta, José Enrique; Giménez, Eugenio; Martínez-Barranco, Pilar; Mateos, Juan José; Casado, Luis Felipe; Bladé, Joan; Lahuerta, Juan José; de la Cruz, Javier; San-Miguel, Jesús title: Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality date: 2020-10-19 journal: Blood Cancer J DOI: 10.1038/s41408-020-00372-5 sha: doc_id: 290295 cord_uid: gl144dh9 file: cache/cord-290051-22gwwrpw.json key: cord-290051-22gwwrpw authors: Masaki, Shigenori; Yamada, Chizuko; Kawamoto, Takashi title: Endotracheal intubation in patients with COVID-19 using an ultrathin flexible gastrointestinal endoscope date: 2020-10-16 journal: World J Gastrointest Endosc DOI: 10.4253/wjge.v12.i10.404 sha: doc_id: 290051 cord_uid: 22gwwrpw file: cache/cord-290341-ei768v4s.json key: cord-290341-ei768v4s authors: Anstey, D. Edmund; Givens, Raymond; Clerkin, Kevin; Fried, Justin; Kalcheva, Nellie; Kumaraiah, Deepa; Masoumi, Amirali; O'Connor, Daniel; Rosner, Gregg F.; Wasson, Lauren; Hammond, Jeffrey; Kirtane, Ajay; Uriel, Nir; Schwartz, Allan; Rabbani, LeRoy; Abdalla, Marwah title: The cardiac intensive care unit and the cardiac Intensivist during the COVID-19 surge in New York City() date: 2020-07-03 journal: Am Heart J DOI: 10.1016/j.ahj.2020.06.018 sha: doc_id: 290341 cord_uid: ei768v4s file: cache/cord-290658-r2bqqovo.json key: cord-290658-r2bqqovo authors: Qian, Hao; Gao, Peng; Tian, Ran; Yang, Xufei; Guo, Fan; Li, Taisheng; Liu, Zhengyin; Wang, Jinglan; Zhou, Xiang; Qin, Yan; Chang, Long; Song, Yanjun; Yan, Xiaowei; Wu, Wei; Zhang, Shuyang title: Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: a Retrospective in-ICU Study date: 2020-10-16 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.10.019 sha: doc_id: 290658 cord_uid: r2bqqovo file: cache/cord-290712-flj352ql.json key: cord-290712-flj352ql authors: Bi, Jianping; Ma, Hong; Zhang, Dongsheng; Huang, Jing; Yang, Dongqin; Wang, Yajie; Verma, Vivek; Zhang, Tao; Hu, Desheng; Mei, Qi; Han, Guang; Li, Jian title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? date: 2020-09-04 journal: Eur Respir J DOI: 10.1183/13993003.02672-2020 sha: doc_id: 290712 cord_uid: flj352ql file: cache/cord-289852-4uxb70rh.json key: cord-289852-4uxb70rh authors: Kassem, Dina H.; Kamal, Mohamed M. title: Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis date: 2020-09-30 journal: Front Cell Dev Biol DOI: 10.3389/fcell.2020.587866 sha: doc_id: 289852 cord_uid: 4uxb70rh file: cache/cord-290195-8uaai9nv.json key: cord-290195-8uaai9nv authors: Stebbing, Justin; Krishnan, Venkatesh; de Bono, Stephanie; Ottaviani, Silvia; Casalini, Giacomo; Richardson, Peter J.; Monteil, Vanessa; Lauschke, Volker M.; Mirazimi, Ali; Youhanna, Sonia; Tan, Yee‐Joo; Baldanti, Fausto; Sarasini, Antonella; Terres, Jorge A. Ross; Nickoloff, Brian J.; Higgs, Richard E.; Rocha, Guilherme; Byers, Nicole L.; Schlichting, Douglas E.; Nirula, Ajay; Cardoso, Anabela; Corbellino, Mario title: Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients date: 2020-05-30 journal: EMBO Mol Med DOI: 10.15252/emmm.202012697 sha: doc_id: 290195 cord_uid: 8uaai9nv file: cache/cord-290750-85731og8.json key: cord-290750-85731og8 authors: Danese, Silvio; Cecconi, Maurizio; Spinelli, Antonino title: Management of IBD during the COVID-19 outbreak: resetting clinical priorities date: 2020-03-25 journal: Nat Rev Gastroenterol Hepatol DOI: 10.1038/s41575-020-0294-8 sha: doc_id: 290750 cord_uid: 85731og8 file: cache/cord-290975-2kmvyovm.json key: cord-290975-2kmvyovm authors: Martinotti, Giovanni; Alessi, Maria Chiara; Di Natale, Chiara; Sociali, Antonella; Ceci, Franca; Lucidi, Lorenza; Picutti, Elena; Di Carlo, Francesco; Corbo, Mariangela; Vellante, Federica; Fiori, Federica; Tourjansky, Gaia; Catalano, Gabriella; Carenti, Maria Luisa; Incerti, Chiara Concetta; Bartoletti, Luigi; Barlati, Stefano; Romeo, Vincenzo Maria; Verrastro, Valeria; De Giorgio, Fabio; Valchera, Alessandro; Sepede, Gianna; Casella, Pietro; Pettorruso, Mauro; di Giannantonio, Massimo title: Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy date: 2020-09-03 journal: Front Psychiatry DOI: 10.3389/fpsyt.2020.572245 sha: doc_id: 290975 cord_uid: 2kmvyovm file: cache/cord-290326-umv0q4d7.json key: cord-290326-umv0q4d7 authors: Stachowska, Ewa; Folwarski, Marcin; Jamioł-Milc, Dominika; Maciejewska, Dominika; Skonieczna-Żydecka, Karolina title: Nutritional Support in Coronavirus 2019 Disease date: 2020-06-12 journal: Medicina (Kaunas) DOI: 10.3390/medicina56060289 sha: doc_id: 290326 cord_uid: umv0q4d7 file: cache/cord-291016-c83fs5ih.json key: cord-291016-c83fs5ih authors: Gori, Tommaso; Lelieveld, Jos; Münzel, Thomas title: Perspective: cardiovascular disease and the Covid-19 pandemic date: 2020-04-10 journal: Basic Res Cardiol DOI: 10.1007/s00395-020-0792-4 sha: doc_id: 291016 cord_uid: c83fs5ih file: cache/cord-291265-qmylxndp.json key: cord-291265-qmylxndp authors: Moravvej, Zahra; Soltani-Moghadam, Reza; Ahmadian Yazdi, Azam; Shahraki, Kianoush title: COVID-19 pandemic: Ophthalmic practice and precautions in a tertiary eye hospital in Iran date: 2020-04-23 journal: Infection control and hospital epidemiology DOI: 10.1017/ice.2020.164 sha: doc_id: 291265 cord_uid: qmylxndp file: cache/cord-290611-fhaguv3f.json key: cord-290611-fhaguv3f authors: Ghio, Stefano; Baldi, Enrico; Vicentini, Alessandro; Lenti, Marco Vincenzo; Di Sabatino, Antonio; Di Matteo, Angela; Zuccaro, Valentina; Piloni, Davide; Corsico, Angelo; Gnecchi, Massimiliano; Speciale, Francesco; Sabena, Anna; Oltrona Visconti, Luigi; Perlini, Stefano title: Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hospital in Northern Italy date: 2020-09-22 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02493-y sha: doc_id: 290611 cord_uid: fhaguv3f file: cache/cord-290832-zmj59rc3.json key: cord-290832-zmj59rc3 authors: Recinella, Guerino; Marasco, Giovanni; Serafini, Giovanni; Maestri, Lorenzo; Bianchi, Giampaolo; Forti, Paola; Zoli, Marco title: Prognostic role of nutritional status in elderly patients hospitalized for COVID-19: a monocentric study date: 2020-10-08 journal: Aging Clin Exp Res DOI: 10.1007/s40520-020-01727-5 sha: doc_id: 290832 cord_uid: zmj59rc3 file: cache/cord-290856-6de0mwg0.json key: cord-290856-6de0mwg0 authors: Abbo, Aharon (Ronnie); Miller, Asaf; Gazit, Talya; Savir, Yonatan; Caspi, Oren title: Technological Developments and Strategic Management for Overcoming the COVID-19 Challenge within the Hospital Setting in Israel date: 2020-07-31 journal: Rambam Maimonides Med J DOI: 10.5041/rmmj.10417 sha: doc_id: 290856 cord_uid: 6de0mwg0 file: cache/cord-290947-5ewpvo4j.json key: cord-290947-5ewpvo4j authors: Carda, Stefano; Invernizzi, Marco; Bavikatte, Ganesh; Bensmaïl, Djamel; Bianchi, Francesca; Deltombe, Thierry; Draulans, Nathalie; Esquenazi, Alberto; Francisco, Gerard E.; Gross, Raphaël; Jacinto, Luis Jorge; Pérez, Susana Moraleda; O’Dell, Michael W.; Reebye, Rajiv; Verduzco-Gutierrez, Monica; Wissel, Jörg; Molteni, Franco title: The role of physical and rehabilitation medicine in the COVID-19 pandemic: the clinician's view date: 2020-04-18 journal: Ann Phys Rehabil Med DOI: 10.1016/j.rehab.2020.04.001 sha: doc_id: 290947 cord_uid: 5ewpvo4j file: cache/cord-291052-nstfe15a.json key: cord-291052-nstfe15a authors: Cag, Yasemin; Icten, Sacit; Isik-Goren, Burcu; Baysal, Naciye Betul; Bektas, Begum; Selvi, Ece; Ergen, Pinar; Aydin, Ozlem; Ucisik, Ayse Canan; Yilmaz-Karadag, Fatma; Caskurlu, Hulya; Akarsu-Ayazoglu, Tulin; Kocoglu, Hasan; Uzman, Sinan; Nural-Pamukcu, Muge; Arslan, Ferhat; Bas, Gurhan; Kalcioglu, Mahmut Tayyar; Vahaboglu, Haluk title: A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort date: 2020-08-27 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-020-04016-1 sha: doc_id: 291052 cord_uid: nstfe15a file: cache/cord-291024-9g4om4sf.json key: cord-291024-9g4om4sf authors: Isakbaeva, Elmira T.; Khetsuriani, Nino; Beard, R. Suzanne; Peck, Angela; Erdman, Dean; Monroe, Stephan S.; Tong, Suxiang; Ksiazek, Thomas G.; Lowther, Sara; Smith, Indra Pandya; Anderson, Larry J.; Lingappa, Jairam; Widdowson, Marc-Alain title: SARS-associated Coronavirus Transmission, United States date: 2004-02-17 journal: Emerg Infect Dis DOI: 10.3201/eid1002.030734 sha: doc_id: 291024 cord_uid: 9g4om4sf file: cache/cord-291340-8gj0ofmp.json key: cord-291340-8gj0ofmp authors: Misra, Anoop title: Balanced Nutrition is Needed in Times of COVID19 Epidemic in India: A Call for Action for all Nutritionists and Physicians date: 2020-08-27 journal: Diabetes Metab Syndr DOI: 10.1016/j.dsx.2020.08.030 sha: doc_id: 291340 cord_uid: 8gj0ofmp file: cache/cord-290771-18dj37dj.json key: cord-290771-18dj37dj authors: Tzeng, Ching-Wei D.; Teshome, Mediget; Katz, Matthew H. G.; Weinberg, Jeffrey S.; Lai, Stephen Y.; Antonoff, Mara B.; Bird, Justin E.; Shafer, Aaron; Davis, John W.; Adelman, David M.; Moon, Bryan; Reece, Gregory; Prabhu, Sujit S.; DeSnyder, Sarah M.; Skibber, John M.; Mehran, Reza; Schmeler, Kathleen; Roland, Christina L.; Tran Cao, Hop S.; Aloia, Thomas A.; Caudle, Abigail S.; Swisher, Stephen G.; Vauthey, Jean-Nicolas title: Cancer Surgery Scheduling During and After the COVID-19 First Wave: The MD Anderson Cancer Center Experience date: 2020-05-18 journal: Ann Surg DOI: 10.1097/sla.0000000000004092 sha: doc_id: 290771 cord_uid: 18dj37dj file: cache/cord-290836-jldfrec9.json key: cord-290836-jldfrec9 authors: Laosa, Olga; Pedraza, Laura; Álvarez-Bustos, Alejandro; Carnicero, Jose A.; Rodriguez-Artalejo, Fernando; Rodriguez-Mañas, Leocadio title: Rapid assessment at hospital admission of mortality risk from COVID-19: the role of functional status date: 2020-10-08 journal: J Am Med Dir Assoc DOI: 10.1016/j.jamda.2020.10.002 sha: doc_id: 290836 cord_uid: jldfrec9 file: cache/cord-291168-4u4cssky.json key: cord-291168-4u4cssky authors: Martin-Villares, Cristina; Perez Molina-Ramirez, Carmen; Bartolome-Benito, Margarita; Bernal-Sprekelsen, Manuel title: Outcome of 1890 tracheostomies for critical COVID-19 patients: a national cohort study in Spain date: 2020-08-04 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06220-3 sha: doc_id: 291168 cord_uid: 4u4cssky file: cache/cord-291397-look6ddt.json key: cord-291397-look6ddt authors: Roberto, Palumbo; Francesco, Londrino; Emanuela, Cordova; Giorgia, Gambardella; Pasquale, Niscola; Sara, Dominijanni title: Current treatment of COVID-19 in renal patients: hope or hype? date: 2020-09-28 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02510-0 sha: doc_id: 291397 cord_uid: look6ddt file: cache/cord-291025-u5z8zji3.json key: cord-291025-u5z8zji3 authors: Karami, Parisa; Naghavi, Maliheh; Feyzi, Abdolamir; Aghamohammadi, Mehdi; Novin, Mohammad Sadegh; Mobaien, Ahmadreza; Qorbanisani, Mohamad; Karami, Aida; Norooznezhad, Amir Hossein title: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings date: 2020-04-11 journal: Travel Med Infect Dis DOI: 10.1016/j.tmaid.2020.101665 sha: doc_id: 291025 cord_uid: u5z8zji3 file: cache/cord-291176-evb6yt0r.json key: cord-291176-evb6yt0r authors: Giorgi Rossi, Paolo; Marino, Massimiliano; Formisano, Debora; Venturelli, Francesco; Vicentini, Massimo; Grilli, Roberto title: Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy date: 2020-08-27 journal: PLoS One DOI: 10.1371/journal.pone.0238281 sha: doc_id: 291176 cord_uid: evb6yt0r file: cache/cord-291244-o4isx15k.json key: cord-291244-o4isx15k authors: Ikuyama, Yuichi; Wada, Yosuke; Tateishi, Kazunari; Kitaguchi, Yoshiaki; Yasuo, Masanori; Ushiki, Atsuhito; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Kamijo, Hiroshi; Mita, Atsuyoshi; Imamura, Hiroshi; Hanaoka, Masayuki title: Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date: 2020-05-31 journal: Respir Med Case Rep DOI: 10.1016/j.rmcr.2020.101113 sha: doc_id: 291244 cord_uid: o4isx15k file: cache/cord-291388-tt9eq7e0.json key: cord-291388-tt9eq7e0 authors: Wang, Jann-Tay; Sheng, Wang-Huei; Fang, Chi-Tai; Chen, Yee-Chun; Wang, Jiun-Ling; Yu, Chong-Jen; Chang, Shan-Chwen; Yang, Pan-Chyr title: Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients date: 2004-05-17 journal: Emerg Infect Dis DOI: 10.3201/eid1005.030640 sha: doc_id: 291388 cord_uid: tt9eq7e0 file: cache/cord-291469-cohrewj5.json key: cord-291469-cohrewj5 authors: Cortese, Bernardo title: How is the cardiovascular patient managed during Covid‐19 pandemic? A report from the frontline date: 2020-05-20 journal: Catheter Cardiovasc Interv DOI: 10.1002/ccd.28966 sha: doc_id: 291469 cord_uid: cohrewj5 file: cache/cord-291413-cgec7150.json key: cord-291413-cgec7150 authors: Al-Jehani, Hosam; John, Seby; Hussain, Syed Irteza; Al Hashmi, Amal; Alhamid, May Adel; Amr, Dareen; Ozdemir, Atilla Ozcan; Shuaib, Ashfaq; Alhazzani, Adel; Ghorbani, Mohammad; Mansour, Ossama; Saqqur, Maher title: MENA-SINO Consensus Statement on Implementing Care Pathways for Acute Neurovascular Emergencies During the COVID-19 Pandemic date: 2020-08-25 journal: Front Neurol DOI: 10.3389/fneur.2020.00928 sha: doc_id: 291413 cord_uid: cgec7150 file: cache/cord-291624-fod0eyuj.json key: cord-291624-fod0eyuj authors: Malone, Robert W.; Tisdall, Philip; Fremont-Smith, Philip; Liu, Yongfeng; Huang, Xi-Ping; White, Kris M.; Miorin, Lisa; Olmo, Elena Moreno Del; Alon, Assaf; Delaforge, Elise; Hennecker, Christopher D.; Wang, Guanyu; Pottel, Joshua; Bona, Robert; Smith, Nora; Hall, Julie M.; Shapiro, Gideon; Clark, Howard; Mittermaier, Anthony; Kruse, Andrew C.; García-Sastre, Adolfo; Roth, Bryan L.; Glasspool-Malone, Jill; Francone, Victor; Hertzog, Norbert; Fremont-Smith, Maurice; Ricke, Darrell O. title: COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms date: 2020-06-22 journal: Res Sq DOI: 10.21203/rs.3.rs-30934/v2 sha: doc_id: 291624 cord_uid: fod0eyuj file: cache/cord-291686-kgewmqg5.json key: cord-291686-kgewmqg5 authors: Patel, Surendra; Kaushik, Atul; Sharma, Alok Kumar title: Prioritizing cardiovascular surgical care in COVID‐19 pandemic: Shall we operate or defer? date: 2020-07-15 journal: J Card Surg DOI: 10.1111/jocs.14864 sha: doc_id: 291686 cord_uid: kgewmqg5 file: cache/cord-291588-tp89j1kk.json key: cord-291588-tp89j1kk authors: Dorche, Maryam Sharifian; Huot, Philippe; Osherov, Micheal; Wen, Dingke; Saveriano, Alexander; Giacomini, Paul; Antel, Jack P.; Mowla, Ashkan title: Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic date: 2020-08-07 journal: J Neurol Sci DOI: 10.1016/j.jns.2020.117085 sha: doc_id: 291588 cord_uid: tp89j1kk file: cache/cord-291417-p49ukyhx.json key: cord-291417-p49ukyhx authors: Mikulska, Malgorzata; Nicolini, Laura Ambra; Signori, Alessio; Di Biagio, Antonio; Sepulcri, Chiara; Russo, Chiara; Dettori, Silvia; Berruti, Marco; Sormani, Maria Pia; Giacobbe, Daniele Roberto; Vena, Antonio; De Maria, Andrea; Dentone, Chiara; Taramasso, Lucia; Mirabella, Michele; Magnasco, Laura; Mora, Sara; Delfino, Emanuele; Toscanini, Federica; Balletto, Elisa; Alessandrini, Anna Ida; Baldi, Federico; Briano, Federica; Camera, Marco; Dodi, Ferdinando; Ferrazin, Antonio; Labate, Laura; Mazzarello, Giovanni; Pincino, Rachele; Portunato, Federica; Tutino, Stefania; Barisione, Emanuela; Bruzzone, Bianca; Orsi, Andrea; Schenone, Eva; Rosseti, Nirmala; Sasso, Elisabetta; Da Rin, Giorgio; Pelosi, Paolo; Beltramini, Sabrina; Giacomini, Mauro; Icardi, Giancarlo; Gratarola, Angelo; Bassetti, Matteo title: Tocilizumab and steroid treatment in patients with COVID-19 pneumonia date: 2020-08-20 journal: PLoS One DOI: 10.1371/journal.pone.0237831 sha: doc_id: 291417 cord_uid: p49ukyhx file: cache/cord-291430-rsu6xviv.json key: cord-291430-rsu6xviv authors: Zhang, Qian; Shan, Khine S; Gopisetti, Neethu; Yoon, Thomas; Iqbal, Iqra title: A Mysterious Paratracheal Mass: Parathyroid Carcinoma date: 2020-07-11 journal: Cureus DOI: 10.7759/cureus.9126 sha: doc_id: 291430 cord_uid: rsu6xviv file: cache/cord-291670-mqj071gp.json key: cord-291670-mqj071gp authors: Raredon, M. S. B.; Fisher, C.; Heerdt, P.; Deshpande, R.; Nivison, S.; Fajardo, E.; Akhtar, S.; Raredon, T.; Niklason, L. E. title: Pressure-Regulated Ventilator Splitting (PReVentS): A COVID-19 Response Paradigm from Yale University date: 2020-04-06 journal: nan DOI: 10.1101/2020.04.03.20052217 sha: doc_id: 291670 cord_uid: mqj071gp file: cache/cord-292056-dtdyxhq4.json key: cord-292056-dtdyxhq4 authors: Ghogawala, Zoher; Kurpad, Shekar; Falavigna, Asdrubal; Groff, Michael W.; Sciubba, Daniel M.; Wu, Jau-Ching; Park, Paul; Berven, Sigurd; Hoh, Daniel J.; Bisson, Erica F.; Steinmetz, Michael P.; Wang, Marjorie C.; Chou, Dean; Sansur, Charles A.; Smith, Justin S.; Tumialán, Luis M. title: Editorial. COVID-19 and spinal surgery date: 2020-04-17 journal: J Neurosurg Spine DOI: 10.3171/2020.4.spine20468 sha: doc_id: 292056 cord_uid: dtdyxhq4 file: cache/cord-292345-zc209dfx.json key: cord-292345-zc209dfx authors: Carroll, Elizabeth; Lewis, Ariane title: Catastrophic Intracranial Hemorrhage in Two Critically Ill Patients with COVID-19 date: 2020-05-26 journal: Neurocrit Care DOI: 10.1007/s12028-020-00993-5 sha: doc_id: 292345 cord_uid: zc209dfx file: cache/cord-291566-jwlvustd.json key: cord-291566-jwlvustd authors: Wells Mulherin, Diana; Walker, Renee; Holcombe, Beverly; Guenter, Peggi title: ASPEN Report on Nutrition Support Practice Processes With COVID‐19: The First Response date: 2020-07-16 journal: Nutr Clin Pract DOI: 10.1002/ncp.10553 sha: doc_id: 291566 cord_uid: jwlvustd file: cache/cord-291697-wpnq9wc0.json key: cord-291697-wpnq9wc0 authors: Riechelmann, Rachel P; Peixoto, Renata D’Alpino; Fernandes, Gustavo Dos Santos; Weschenfelder, Rui F; Prolla, Gabriel; Filho, Duílio Rocha; Andrade, Aline Chaves; Crosara, Marcela; Rego, Juliana Florinda M; Gansl, Rene C; Coimbra, Felipe; Aguiar, Samuel; Carvalho, Elisângela; Hoff, Paulo M; Coutinho, Anelisa K title: Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group date: 2020-05-22 journal: Ecancermedicalscience DOI: 10.3332/ecancer.2020.1048 sha: doc_id: 291697 cord_uid: wpnq9wc0 file: cache/cord-292315-7vwybku8.json key: cord-292315-7vwybku8 authors: Jung, Gyuwon; Lee, Hyunsoo; Kim, Auk; Lee, Uichin title: Too Much Information: Assessing Privacy Risks of Contact Trace Data Disclosure on People With COVID-19 in South Korea date: 2020-06-18 journal: Front Public Health DOI: 10.3389/fpubh.2020.00305 sha: doc_id: 292315 cord_uid: 7vwybku8 file: cache/cord-292474-dmgd99d6.json key: cord-292474-dmgd99d6 authors: Berardi, Giammauro; Colasanti, Marco; Levi Sandri, Giovanni Battista; Del Basso, Celeste; Ferretti, Stefano; Laurenzi, Andrea; Guglielmo, Nicola; Meniconi, Roberto Luca; Antonini, Mario; D’Offizi, Gianpiero; Ettorre, Giuseppe Maria title: Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center date: 2020-06-04 journal: Updates Surg DOI: 10.1007/s13304-020-00825-3 sha: doc_id: 292474 cord_uid: dmgd99d6 file: cache/cord-292054-x0saq938.json key: cord-292054-x0saq938 authors: Hashizume, Misato title: Outlook of IL-6 signaling blockade for COVID-19 pneumonia date: 2020-10-05 journal: Inflamm Regen DOI: 10.1186/s41232-020-00134-7 sha: doc_id: 292054 cord_uid: x0saq938 file: cache/cord-291687-kwu0otpi.json key: cord-291687-kwu0otpi authors: Judson, Gregory L.; Kelemen, Benjamin W.; Njoroge, Joyce N.; Mahadevan, Vaikom S. title: Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection date: 2020-06-13 journal: Cardiol Ther DOI: 10.1007/s40119-020-00184-5 sha: doc_id: 291687 cord_uid: kwu0otpi file: cache/cord-292561-iy06b9h9.json key: cord-292561-iy06b9h9 authors: Miesbach, Wolfgang; Makris, Michael title: COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation date: 2020-07-17 journal: Clin Appl Thromb Hemost DOI: 10.1177/1076029620938149 sha: doc_id: 292561 cord_uid: iy06b9h9 file: cache/cord-291855-wtwz94sy.json key: cord-291855-wtwz94sy authors: Tambone, Vittoradolfo; Boudreau, Donald; Ciccozzi, Massimo; Sanders, Karen; Campanozzi, Laura Leondina; Wathuta, Jane; Violante, Luciano; Cauda, Roberto; Petrini, Carlo; Abbate, Antonio; Alloni, Rossana; Argemi, Josepmaria; Argemí Renom, Josep; De Benedictis, Anna; Galerneau, France; García-Sánchez, Emilio; Ghilardi, Giampaolo; Hafler, Janet Palmer; Linden, Magdalena; Marcos, Alfredo; Onetti Muda, Andrea; Pandolfi, Marco; Pelaccia, Thierry; Picozzi, Mario; Revello, Ruben Oscar; Ricci, Giovanna; Rohrbaugh, Robert; Rossi, Patrizio; Sirignano, Ascanio; Spagnolo, Antonio Gioacchino; Stammers, Trevor; Velázquez, Lourdes; Agazzi, Evandro; Mercurio, Mark title: Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic date: 2020-06-16 journal: Front Public Health DOI: 10.3389/fpubh.2020.00284 sha: doc_id: 291855 cord_uid: wtwz94sy file: cache/cord-291873-inzzywps.json key: cord-291873-inzzywps authors: Tognetto, Daniele; Pastore, Marco Rocco; De Giacinto, Chiara; Cecchini, Paolo; Agolini, Rossella; Giglio, Rosa; Vinciguerra, Alex Lucia title: Managing ophthalmic practices in a referral emergency COVID‐19 hospital in north‐east Italy date: 2020-06-01 journal: Acta Ophthalmol DOI: 10.1111/aos.14488 sha: doc_id: 291873 cord_uid: inzzywps file: cache/cord-292620-t8ocqm6g.json key: cord-292620-t8ocqm6g authors: Somani, S.; Richter, F.; Fuster, V.; De Freitas, J.; Naik, N.; Sigel, K.; Mount Sinai Covid Informatics Center,; Boettinger, E. P.; Levin, M. A.; Fayad, Z.; Just, A. C.; Charney, A.; Zhao, S.; Glicksberg, B. S.; Lala, A.; Nadkarni, G. title: Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19 date: 2020-05-22 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.05.17.20104604 sha: doc_id: 292620 cord_uid: t8ocqm6g file: cache/cord-292394-91b3mm6c.json key: cord-292394-91b3mm6c authors: Ashish, A.; Unsworth, A.; Martindale, J.; Sundar, R.; Sedda, L.; Farrier, M. title: Early CPAP reduced mortality in covid-19 patients. Audit results from Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust. date: 2020-06-02 journal: nan DOI: 10.1101/2020.05.28.20116152 sha: doc_id: 292394 cord_uid: 91b3mm6c file: cache/cord-292493-lx7zfgoi.json key: cord-292493-lx7zfgoi authors: Firstenberg, Michael S.; Libby, Matthew; Ochs, Michael; Hanna, Jennifer; Mangino, Julie E.; Forrester, Joseph title: Isolation protocol for a COVID-2019 patient requiring emergent surgical intervention: case presentation date: 2020-04-19 journal: Patient Saf Surg DOI: 10.1186/s13037-020-00243-9 sha: doc_id: 292493 cord_uid: lx7zfgoi file: cache/cord-292335-al6v3b9x.json key: cord-292335-al6v3b9x authors: Crotty, Matthew P.; Meyers, Shelby; Hampton, Nicholas; Bledsoe, Stephanie; Ritchie, David J.; Buller, Richard S.; Storch, Gregory A.; Kollef, Marin H.; Micek, Scott T. title: Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship date: 2015-11-18 journal: Crit Care DOI: 10.1186/s13054-015-1120-5 sha: doc_id: 292335 cord_uid: al6v3b9x file: cache/cord-292485-vk5xy3zn.json key: cord-292485-vk5xy3zn authors: Prasad, Narayan; hatt, Mansi; Agarwal, Sanjay K.; Kohli, H.S.; Gopalakrishnan, N.; Fernando, Edwin; Sahay, Manisha; Rajapurkar, Mohan; Chowdhary, Arpita Roy; Rathi, Manish; Jeloka, Tarun; Lobo, Valentine; Singh, Shivendra; Bhalla, A.K.; Khanna, Umesh; Bansal, S.B.; Rai, P.K.; Bhawane, Amol; Anandh, Urmila; Singh, Ajit Kumar; Shah, Bharat; Gupta, Amit; Jha, Vivekanand title: The adverse effect of COVID pandemic on the care of patients with kidney diseases in India date: 2020-07-06 journal: Kidney Int Rep DOI: 10.1016/j.ekir.2020.06.034 sha: doc_id: 292485 cord_uid: vk5xy3zn file: cache/cord-292350-cmrtg91a.json key: cord-292350-cmrtg91a authors: Mondal, Samhati; Quintili, Ashley L.; Karamchandani, Kunal; Bose, Somnath title: Thromboembolic disease in COVID-19 patients: A brief narrative review date: 2020-09-14 journal: J Intensive Care DOI: 10.1186/s40560-020-00483-y sha: doc_id: 292350 cord_uid: cmrtg91a file: cache/cord-292387-2xv3wgaq.json key: cord-292387-2xv3wgaq authors: D′Agostino, Armando; D’Angelo, Simone; Giordano, Barbara; Cigognini, Anna Chiara; Chirico, Margherita Lorenza; Redaelli, Cristiana; Gambini, Orsola title: Brief Psychotic Disorder During the National Lockdown in Italy: An Emerging Clinical Phenomenon of the COVID-19 Pandemic date: 2020-08-06 journal: Schizophr Bull DOI: 10.1093/schbul/sbaa112 sha: doc_id: 292387 cord_uid: 2xv3wgaq file: cache/cord-292826-lus0tqmi.json key: cord-292826-lus0tqmi authors: Joseph, Tony; Civil, Ian title: Trauma care in a low-COVID pandemic environment: A new normal date: 2020-06-12 journal: Injury DOI: 10.1016/j.injury.2020.05.041 sha: doc_id: 292826 cord_uid: lus0tqmi file: cache/cord-292094-vmsdhccp.json key: cord-292094-vmsdhccp authors: Mandell, Lionel A.; Wunderink, Richard G.; Anzueto, Antonio; Bartlett, John G.; Campbell, G. Douglas; Dean, Nathan C.; Dowell, Scott F.; File, Thomas M.; Musher, Daniel M.; Niederman, Michael S.; Torres, Antonio; Whitney, Cynthia G. title: Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults date: 2007-03-01 journal: Clin Infect Dis DOI: 10.1086/511159 sha: doc_id: 292094 cord_uid: vmsdhccp file: cache/cord-293167-3bd3adip.json key: cord-293167-3bd3adip authors: Nepal, Gaurav; Rehrig, Jessica Holly; Shrestha, Gentle Sunder; Shing, Yow Ka; Yadav, Jayant Kumar; Ojha, Rajeev; Pokhrel, Gaurab; Tu, Zhi Lan; Huang, Dong Ya title: Neurological manifestations of COVID-19: a systematic review date: 2020-07-13 journal: Crit Care DOI: 10.1186/s13054-020-03121-z sha: doc_id: 293167 cord_uid: 3bd3adip file: cache/cord-293285-w8c3ma8l.json key: cord-293285-w8c3ma8l authors: Lanza, F; Seghatchian, J title: Reflection on passive immunotherapy in those who need most: some novel strategic arguments for obtaining safer therapeutic plasma or autologous antibodies from recovered COVID ‐19 infected patients date: 2020-05-14 journal: Br J Haematol DOI: 10.1111/bjh.16814 sha: doc_id: 293285 cord_uid: w8c3ma8l file: cache/cord-293143-1k170shh.json key: cord-293143-1k170shh authors: Dieninghoff, Doris; Karagiannidis, Christian; Straßmann, Stephan; Pieper, Monika; Dammaschek, Sarah; Zabner, Joseph; Klingelhutz, Aloysius; Windisch, Wolfram; Brockmann, Michael; Schildgen, Oliver; Schildgen, Verena title: Fatal HBoV-1 infection in adult female cystic fibrosis patient date: 2016-07-18 journal: Hum Pathol (N Y) DOI: 10.1016/j.ehpc.2016.07.001 sha: doc_id: 293143 cord_uid: 1k170shh file: cache/cord-293180-f1ulk9ce.json key: cord-293180-f1ulk9ce authors: Li, R W K; Leung, K W C; Sun, F C S; Samaranayake, L P title: Severe Acute Respiratory Syndrome (SARS) and the GDP. Part II: Implications for GDPs date: 2004-08-14 journal: Br Dent J DOI: 10.1038/sj.bdj.4811522 sha: doc_id: 293180 cord_uid: f1ulk9ce file: cache/cord-293333-mqoml9o5.json key: cord-293333-mqoml9o5 authors: Scharbarg, Emeric; Moog, Claude H.; Mauduit, Nicolas; Califano, Claudia title: From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves date: 2020-10-03 journal: Annu Rev Control DOI: 10.1016/j.arcontrol.2020.09.007 sha: doc_id: 293333 cord_uid: mqoml9o5 file: cache/cord-293575-h3wc7j4v.json key: cord-293575-h3wc7j4v authors: Adrish, Muhammad; Chilimuri, Sridhar; Mantri, Nikhitha; Sun, Haozhe; Zahid, Maleeha; Gongati, Sudharsan; Fortuzi, Ked; Jog, Abhishrut Pramod; Purmessur, Pravish; Singhal, Ravish title: Association of smoking status with outcomes in hospitalised patients with COVID-19 date: 2020-10-05 journal: BMJ Open Respir Res DOI: 10.1136/bmjresp-2020-000716 sha: doc_id: 293575 cord_uid: h3wc7j4v file: cache/cord-292952-z7ajsf2r.json key: cord-292952-z7ajsf2r authors: Wong, Anselm title: COVID‐19 and toxicity from potential treatments: Panacea or poison date: 2020-05-12 journal: Emerg Med Australas DOI: 10.1111/1742-6723.13537 sha: doc_id: 292952 cord_uid: z7ajsf2r file: cache/cord-293570-gh6ykmea.json key: cord-293570-gh6ykmea authors: Gupta, Rajib K.; Bhargava, Ramya; Shaukat, Al-Aman; Albert, Emily; Leggat, John title: Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease: a report of 2 cases date: 2020-08-04 journal: BMC Nephrol DOI: 10.1186/s12882-020-01970-y sha: doc_id: 293570 cord_uid: gh6ykmea file: cache/cord-293522-gg706q8s.json key: cord-293522-gg706q8s authors: Toumi, Mondher; Aballea, Samuel title: Commentary on “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial” by Gautret et al date: 2020-05-13 journal: J Mark Access Health Policy DOI: 10.1080/20016689.2020.1758390 sha: doc_id: 293522 cord_uid: gg706q8s file: cache/cord-293730-dlqo6fep.json key: cord-293730-dlqo6fep authors: Caratozzolo, Salvatore; Zucchelli, Alberto; Turla, Marinella; Cotelli, Maria Sofia; Fascendini, Sara; Zanni, Mara; Bianchetti, Angelo; Psy, Matteo Peli; Rozzini, Renzo; Boffelli, Stefano; Cappuccio, Melania; Psy, Federica Gottardi; Psy, Chiara Vecchi; Bellandi, Daniele; Caminati, Claudia; Gentile, Simona; Psy, Elena Lucchi; Di Fazio, Ignazio; Psy, Marina Zanetti; Vezzadini, Giuliana; Psy, Chiara Forlani; Psy, Maura Cosseddu; Psy, Rosanna Turrone; Psy, Silvia Pelizzari; Scalvini, Andrea; Di Cesare, Marco; Psy, Marta Grigolo; Falanga, Lina; Medici, Nives; Palamini, Nives; Psy, Elisa Zanacchi; Psy, Eleonora Grossi; Bellelli, Giuseppe; Marengoni, Alessandra; Trabucchi, Marco; Padovani, Alessandro title: The impact of COVID-19 on health status of home-dwelling elderly patients with dementia in East Lombardy, Italy: results from COVIDEM network date: 2020-09-12 journal: Aging Clin Exp Res DOI: 10.1007/s40520-020-01676-z sha: doc_id: 293730 cord_uid: dlqo6fep file: cache/cord-293086-6282sb6b.json key: cord-293086-6282sb6b authors: Liddell, Kathleen; Skopek, Jeffrey M; Palmer, Stephanie; Martin, Stevie; Anderson, Jennifer; Sagar, Andrew title: Who gets the ventilator? Important legal rights in a pandemic date: 2020-05-11 journal: J Med Ethics DOI: 10.1136/medethics-2020-106332 sha: doc_id: 293086 cord_uid: 6282sb6b file: cache/cord-294057-fbox3a5q.json key: cord-294057-fbox3a5q authors: Schlegl, Sandra; Meule, Adrian; Favreau, Matthias; Voderholzer, Ulrich title: Bulimia nervosa in times of the COVID‐19 pandemic—Results from an online survey of former inpatients date: 2020-08-07 journal: Eur Eat Disord Rev DOI: 10.1002/erv.2773 sha: doc_id: 294057 cord_uid: fbox3a5q file: cache/cord-293964-hz5uow2b.json key: cord-293964-hz5uow2b authors: Hermann, Matthias; Pekacka-Egli, Anna-Maria; Witassek, Fabienne; Baumgaertner, Reiner; Schoendorf, Sabine; Spielmanns, Marc title: Feasibility and Efficacy of Cardiopulmonary Rehabilitation following COVID-19 date: 2020-07-22 journal: Am J Phys Med Rehabil DOI: 10.1097/phm.0000000000001549 sha: doc_id: 293964 cord_uid: hz5uow2b file: cache/cord-294487-hcuzxhb3.json key: cord-294487-hcuzxhb3 authors: Shenoi, Susan; Hayward, Kristen; Curran, Megan L.; Kessler, Elizabeth; Mehta, Jay J.; Riebschleger, Meredith P.; Foster, Helen E. title: Telemedicine in pediatric rheumatology: this is the time for the community to embrace a new way of clinical practice date: 2020-10-31 journal: Pediatr Rheumatol Online J DOI: 10.1186/s12969-020-00476-z sha: doc_id: 294487 cord_uid: hcuzxhb3 file: cache/cord-292856-7hjzzxtm.json key: cord-292856-7hjzzxtm authors: Viasus, Diego; Oteo Revuelta, José A.; Martínez-Montauti, Joaquín; Carratalà, Jordi title: Influenza A(H1N1)pdm09-related pneumonia and other complications date: 2012-10-31 journal: Enfermedades Infecciosas y Microbiología Clínica DOI: 10.1016/s0213-005x(12)70104-0 sha: doc_id: 292856 cord_uid: 7hjzzxtm file: cache/cord-294073-65h2mkdy.json key: cord-294073-65h2mkdy authors: Ke, Jia; Lan, Nan; Wang, Ting; Wu, Jin-Jie; He, Zhen; He, Xiao-Sheng; Tao, Kai-Xiong; Qian, Qun; Zhou, Ping-Hong; Li, Guo-Xin; Zheng, Min-Hua; Zhang, Zhong-Tao; Ji, Jia-Fu; Lan, Ping title: Strategies and recommendations for the management of gastrointestinal surgery during the COVID-19 pandemic: experience shared by Chinese surgeons date: 2020-07-03 journal: Gastroenterol Rep (Oxf) DOI: 10.1093/gastro/goaa030 sha: doc_id: 294073 cord_uid: 65h2mkdy file: cache/cord-293547-29i3u83s.json key: cord-293547-29i3u83s authors: Pfaar, O; Klimek, L; Jutel, M; Akdis, CA; Bousquet, J; Breiteneder, H; Chinthrajah, S; Diamant, Z; Eiwegger, T; Fokkens, WJ; Fritsch, HW; Nadeau, KC; O’Hehir, RE; O’Mahony, L; Rief, W; Sampath, V; Schedlowski, M; Torres, M; Traidl‐Hoffmann, C; Wang, DY; Zhang, L; Bonini, M; Brehler, R; Brough, HA; Chivato, T; Del Giacco, S; Dramburg, S; Gawlik, R; Gelincik, A; Hoffmann‐Sommergruber, K; Hox, V; Knol, E; Lauerma, A; Matricardi, PM; Mortz, CG; Ollert, M; Palomares, O; Riggioni, C; Schwarze, J; Skypala, I; Untersmayr, S; Walusiak‐Skorupa, J; Ansotegui, I; Bachert, C; Bedbrook, A; Bosnic‐Anticevich, S; Brussino, L; Canonica, GW; Cardona, V; Carreiro‐Martins, P; Cruz, AA; Czarlewski, W; Fonseca, JA; Gotua, M; Haatela, T; Ivancevich, JC; Kuna, P; Kvedariene, V; Larenas‐Linnemann, D; Latiff, A; Morais‐Almeida, M; Mullol, J; Naclerio, R; Ohta, K; Okamoto, Y; Onorato, GL; Papadopoulos, NG; Patella, V; Regateiro, FS; Samolinski, B; Suppli Ulrik, C; Toppila‐Salmi, S; Valiulis, A; Ventura, MT; Yorgancioglu, A; Zuberbier, T; Agache, I title: COVID‐19 pandemic: Practical considerations on the organization of an allergy clinic – an EAACI/ARIA Position Paper date: 2020-06-12 journal: Allergy DOI: 10.1111/all.14453 sha: doc_id: 293547 cord_uid: 29i3u83s file: cache/cord-294108-uvnh0s9r.json key: cord-294108-uvnh0s9r authors: Dube, Taru; Ghosh, Amrito; Mishra, Jibanananda; Kompella, Uday B.; Panda, Jiban Jyoti title: Repurposed Drugs, Molecular Vaccines, Immune‐Modulators, and Nanotherapeutics to Treat and Prevent COVID‐19 Associated with SARS‐CoV‐2, a Deadly Nanovector date: 2020-10-25 journal: Adv Ther (Weinh) DOI: 10.1002/adtp.202000172 sha: doc_id: 294108 cord_uid: uvnh0s9r file: cache/cord-294336-fqobpo47.json key: cord-294336-fqobpo47 authors: Soy, Mehmet; Atagündüz, Pamir; Atagündüz, Işık; Sucak, Gülsan Türköz title: Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic date: 2020-06-25 journal: Rheumatol Int DOI: 10.1007/s00296-020-04636-y sha: doc_id: 294336 cord_uid: fqobpo47 file: cache/cord-293852-r72c6584.json key: cord-293852-r72c6584 authors: Greco, S.; Madè, A.; Gaetano, C.; Devaux, Y.; Emanueli, C.; Martelli, F. title: Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era date: 2020-10-31 journal: J Transl Med DOI: 10.1186/s12967-020-02582-8 sha: doc_id: 293852 cord_uid: r72c6584 file: cache/cord-293472-d3iwlpsr.json key: cord-293472-d3iwlpsr authors: Afilalo, Marc; Stern, Errol; Oughton, Matthew title: Evaluation and Management of Seasonal Influenza in the Emergency Department date: 2012-04-06 journal: Emerg Med Clin North Am DOI: 10.1016/j.emc.2011.10.011 sha: doc_id: 293472 cord_uid: d3iwlpsr file: cache/cord-294184-jte9xx5e.json key: cord-294184-jte9xx5e authors: Macleod, Jack; Mezher, Sermed; Hasan, Ragheb title: Surgery during COVID-19 crisis conditions: can we protect our ethical integrity against the odds? date: 2020-06-12 journal: J Med Ethics DOI: 10.1136/medethics-2020-106446 sha: doc_id: 294184 cord_uid: jte9xx5e file: cache/cord-294270-do6i6ymq.json key: cord-294270-do6i6ymq authors: Banu, Buyukaydin title: Pneumonia date: 2019-11-29 journal: Encyclopedia of Biomedical Gerontology DOI: 10.1016/b978-0-12-801238-3.62174-8 sha: doc_id: 294270 cord_uid: do6i6ymq file: cache/cord-293634-4rryqbnu.json key: cord-293634-4rryqbnu authors: Rosen, Kelsey; Patel, Monika; Lawrence, Cecelia; Mooney, Brianne title: Delivering Telerehabilitation to COVID-19 Inpatients:A Retrospective Chart Review Suggests It Is a Viable Option date: 2020-07-16 journal: HSS J DOI: 10.1007/s11420-020-09774-4 sha: doc_id: 293634 cord_uid: 4rryqbnu file: cache/cord-293922-knzv4jvj.json key: cord-293922-knzv4jvj authors: Zuo, Y.; Warnock, M.; Harbaugh, A.; Yalavarthi, S.; Gockman, K.; Zuo, M.; Madison, J. A.; Knight, J. S.; Kanthi, Y.; Lawrence, D. A. title: Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients date: 2020-09-02 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.08.29.20184358 sha: doc_id: 293922 cord_uid: knzv4jvj file: cache/cord-294139-78c5h7la.json key: cord-294139-78c5h7la authors: Yamakawa, Mai; Kuno, Toshiki; Mikami, Takahisa; Takagi, Hisato; Gronseth, Gary title: Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis date: 2020-08-29 journal: J Stroke Cerebrovasc Dis DOI: 10.1016/j.jstrokecerebrovasdis.2020.105288 sha: doc_id: 294139 cord_uid: 78c5h7la file: cache/cord-294349-ps3qlho2.json key: cord-294349-ps3qlho2 authors: Al-Sharif, Eman; Strianese, Diego; AlMadhi, Nada H.; D’Aponte, Antonella; dell’Omo, Roberto; Di Benedetto, Rita; Costagliola, Ciro title: Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye date: 2020-09-03 journal: Int Ophthalmol DOI: 10.1007/s10792-020-01575-2 sha: doc_id: 294349 cord_uid: ps3qlho2 file: cache/cord-294443-w6p3f5qc.json key: cord-294443-w6p3f5qc authors: Nadar, Sunil K.; Tayebjee, Muzahir H.; Stowasser, Michael; Byrd, James Brian title: Managing hypertension during the COVID-19 pandemic date: 2020-05-14 journal: J Hum Hypertens DOI: 10.1038/s41371-020-0356-y sha: doc_id: 294443 cord_uid: w6p3f5qc file: cache/cord-294617-i8j36bol.json key: cord-294617-i8j36bol authors: Dhar, Shabir A; Wani, Zaid A title: My fear, my morals: a surgeon’s perspective of the COVID crisis date: 2020-10-14 journal: Philos Ethics Humanit Med DOI: 10.1186/s13010-020-00094-3 sha: doc_id: 294617 cord_uid: i8j36bol file: cache/cord-293704-tnik6sd3.json key: cord-293704-tnik6sd3 authors: Tey, Jeremy; Ho, Shaun; Choo, Bok Ai; Ho, Francis; Yap, Swee Peng; Tuan, Jeffrey K.L.; Leong, Cheng Nang; Cheo, Timothy; Sommat, Kiattisa; Wang, Michael L.C. title: Navigating the challenges of the COVID-19 outbreak: perspectives from the radiation oncology service in singapore date: 2020-03-31 journal: Radiother Oncol DOI: 10.1016/j.radonc.2020.03.030 sha: doc_id: 293704 cord_uid: tnik6sd3 file: cache/cord-295123-x2gxgave.json key: cord-295123-x2gxgave authors: Zhou, Wei; Liu, Yisi; Tian, Dongdong; Wang, Cheng; Wang, Sa; Cheng, Jing; Hu, Ming; Fang, Minghao; Gao, Yue title: Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia date: 2020-02-21 journal: Signal Transduct Target Ther DOI: 10.1038/s41392-020-0127-9 sha: doc_id: 295123 cord_uid: x2gxgave file: cache/cord-294636-xes8g0x4.json key: cord-294636-xes8g0x4 authors: Brindle, Mary E.; Doherty, Gerard; Lillemoe, Keith; Gawande, Atul title: Approaching Surgical Triage During the COVID-19 Pandemic date: 2020-05-07 journal: Ann Surg DOI: 10.1097/sla.0000000000003992 sha: doc_id: 294636 cord_uid: xes8g0x4 file: cache/cord-294294-66udu5y4.json key: cord-294294-66udu5y4 authors: Bullock, Travis S.; Gutierrez-Naranjo, Jose M.; DelBello, Robert G.; Karia, Ravi A.; Zelle, Boris A. title: Outpatient surgery in patients with ankle fractures minimises hospital admissions and utilisation of healthcare resources date: 2020-08-08 journal: Int Orthop DOI: 10.1007/s00264-020-04768-7 sha: doc_id: 294294 cord_uid: 66udu5y4 file: cache/cord-294079-px9c20il.json key: cord-294079-px9c20il authors: Chua, Horng-Ruey; Laren, Graeme Mac; Choong, Lina Hui-Lin; Chionh, Chang-Yin; Khoo, Benjamin Zhi En; Yeo, See-Cheng; Sewa, Duu-Wen; Ng, Shin-Yi; Choo, Jason Chon-Jun; Teo, Boon-Wee; Tan, Han-Khim; Siow, Wen-Ting; Agrawal, Rohit; Tan, Chieh-Suai; Vathsala, Anantharaman; Tagore, Rajat; Seow, Terina Ying-Ying; Khatri, Priyanka; Hong, Wei-Zhen; Kaushik, Manish title: Ensuring Sustainability of Continuous Kidney Replacement Therapy in the Face of Extraordinary Demand: Lessons From the COVID-19 Pandemic date: 2020-06-04 journal: Am J Kidney Dis DOI: 10.1053/j.ajkd.2020.05.008 sha: doc_id: 294079 cord_uid: px9c20il file: cache/cord-294527-fct2y5vn.json key: cord-294527-fct2y5vn authors: Guadarrama-Ortiz, Parménides; Choreño-Parra, José Alberto; Sánchez-Martínez, Claudia Marisol; Pacheco-Sánchez, Francisco Javier; Rodríguez-Nava, Alberto Iván; García-Quintero, Gabriela title: Neurological Aspects of SARS-CoV-2 Infection: Mechanisms and Manifestations date: 2020-09-04 journal: Front Neurol DOI: 10.3389/fneur.2020.01039 sha: doc_id: 294527 cord_uid: fct2y5vn file: cache/cord-293740-4c3yemi3.json key: cord-293740-4c3yemi3 authors: Ferrando, Carlos; Suarez-Sipmann, Fernando; Mellado-Artigas, Ricard; Hernández, María; Gea, Alfredo; Arruti, Egoitz; Aldecoa, César; Martínez-Pallí, Graciela; Martínez-González, Miguel A.; Slutsky, Arthur S.; Villar, Jesús title: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS date: 2020-07-29 journal: Intensive Care Med DOI: 10.1007/s00134-020-06192-2 sha: doc_id: 293740 cord_uid: 4c3yemi3 file: cache/cord-294371-xot2oj2t.json key: cord-294371-xot2oj2t authors: Citgez, Bulent; Yigit, Banu; Capkinoglu, Emir; Yetkin, Sitki Gurkan title: Management of Breast Cancer during the COVID-19 Pandemic date: 2020-06-10 journal: Sisli Etfal Hastan Tip Bul DOI: 10.14744/semb.2020.23326 sha: doc_id: 294371 cord_uid: xot2oj2t file: cache/cord-294907-i836d6im.json key: cord-294907-i836d6im authors: Alabdali, Abdullah; Almakhalas, Kharsan; Alhusain, Faisal; Albaiz, Saad; Almutairi, Khalid; Aljerian, Nawfal title: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak at King Abdul-Aziz Medical City-Riyadh from Emergency Medical Services Perspective date: 2020-05-20 journal: Prehospital and disaster medicine DOI: 10.1017/s1049023x20000709 sha: doc_id: 294907 cord_uid: i836d6im file: cache/cord-294064-vdpak3fm.json key: cord-294064-vdpak3fm authors: Iqbal, Muhammad Rafaih; Dhahri, Adeel Abbas; Mustafa Darwish, Nourelhuda Mohammed; Vijay, Vardhini title: Single centre concept of ‘cold site’ elective surgery during the peak of COVID-19 pandemic: A cohort study date: 2020-10-06 journal: Ann Med Surg (Lond) DOI: 10.1016/j.amsu.2020.09.047 sha: doc_id: 294064 cord_uid: vdpak3fm file: cache/cord-294628-ecg13s7a.json key: cord-294628-ecg13s7a authors: Chia, Ming Li; Him Chau, Dickson Hong; Lim, Kheng Sit; Yang Liu, Christopher Wei; Tan, Hiang Khoon; Tan, Yan Ru title: Managing COVID-19 in a Novel, Rapidly Deployable Community Isolation Quarantine Facility date: 2020-09-17 journal: Ann Intern Med DOI: 10.7326/m20-4746 sha: doc_id: 294628 cord_uid: ecg13s7a file: cache/cord-294933-oc2glu4a.json key: cord-294933-oc2glu4a authors: Cinesi Gómez, César; Peñuelas Rodríguez, Óscar; Luján Torné, Manel; Egea Santaolalla, Carlos; Masa Jiménez, Juan Fernando; García Fernández, Javier; Carratalá Perales, José Manuel; Heili-Frades, Sarah Béatrice; Ferrer Monreal, Miquel; de Andrés Nilsson, José M.; Lista Arias, Eva; Sánchez Rocamora, Juan Luis; Garrote, José Ignacio; Zamorano Serrano, Miguel J.; González Martínez, Mónica; Farrero Muñoz, Eva; Mediano San Andrés, Olga; Rialp Cervera, Gemma; Mas Serra, Arantxa; Hernández Martínez, Gonzalo; de Haro López, Candelaria; Roca Gas, Oriol; Ferrer Roca, Ricard; Romero Berrocal, Antonio; Ferrando Ortola, Carlos title: Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection date: 2020-06-19 journal: nan DOI: 10.1016/j.medine.2020.03.002 sha: doc_id: 294933 cord_uid: oc2glu4a file: cache/cord-294959-xy8976jz.json key: cord-294959-xy8976jz authors: Hsu, Elisabeth; Zhu, Buxian; Ding, Zewan title: Allium fistulosum congee as a home remedy to ward off the corona virus at an early stage date: 2020-06-30 journal: Integr Med Res DOI: 10.1016/j.imr.2020.100463 sha: doc_id: 294959 cord_uid: xy8976jz file: cache/cord-294768-bs6thjw2.json key: cord-294768-bs6thjw2 authors: Alonso-Fernández, Alberto; Toledo-Pons, Nuria; Cosío, Borja G.; Millán, Aina; Calvo, Néstor; Ramón, Luisa; de Mendoza, Sara Hermoso; Morell-García, Daniel; Bauça-Rossello, Josep Miquel; Núñez, Belén; Pons, Jaume; Palmer, Juan A.; Martín, Luisa; Peñaranda, María; Pou, Joan A.; Sauleda, Jaume; Sala-Llinas, Ernest title: Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study date: 2020-08-25 journal: PLoS One DOI: 10.1371/journal.pone.0238216 sha: doc_id: 294768 cord_uid: bs6thjw2 file: cache/cord-294969-57xgqf2g.json key: cord-294969-57xgqf2g authors: Green, Bart N.; Pence, Ti V.; Kwan, Lawrence; Rokicki-Parashar, Jesse title: Rapid Deployment of Chiropractic Telehealth at 2 Worksite Health Centers in Response to the COVID-19 Pandemic: Observations from the Field date: 2020-06-11 journal: J Manipulative Physiol Ther DOI: 10.1016/j.jmpt.2020.05.008 sha: doc_id: 294969 cord_uid: 57xgqf2g file: cache/cord-295216-eff02z0i.json key: cord-295216-eff02z0i authors: Ahluwalia, Ranbir; Rocque, Brandon G.; Shannon, Chevis N.; Blount, Jeffrey P. title: The impact of imposed delay in elective pediatric neurosurgery: an informed hierarchy of need in the time of mass casualty crisis date: 2020-05-20 journal: Childs Nerv Syst DOI: 10.1007/s00381-020-04671-x sha: doc_id: 295216 cord_uid: eff02z0i file: cache/cord-295514-vhymj0rw.json key: cord-295514-vhymj0rw authors: Lim, Peter A; Ng, Yee Sien; Tay, Boon Keng title: Impact of a viral respiratory epidemic on the practice of medicine and rehabilitation: Severe acute respiratory syndrome date: 2004-08-01 journal: Arch Phys Med Rehabil DOI: 10.1016/j.apmr.2004.01.022 sha: doc_id: 295514 cord_uid: vhymj0rw file: cache/cord-294557-4h0sybiy.json key: cord-294557-4h0sybiy authors: Stogiannos, N.; Fotopoulos, D.; Woznitza, N.; Malamateniou, C. title: Coronavirus disease 2019 (COVID-19) in the radiology department: What radiographers need to know date: 2020-06-04 journal: Radiography (Lond) DOI: 10.1016/j.radi.2020.05.012 sha: doc_id: 294557 cord_uid: 4h0sybiy file: cache/cord-295086-tc3re52f.json key: cord-295086-tc3re52f authors: Lu, Guoguang; Wang, Jing title: Dynamic changes in routine blood parameters of a severe COVID-19 case date: 2020-05-13 journal: Clin Chim Acta DOI: 10.1016/j.cca.2020.04.034 sha: doc_id: 295086 cord_uid: tc3re52f file: cache/cord-295332-wlnss6bg.json key: cord-295332-wlnss6bg authors: AL Shareef, Khaled; Bakouri, Mohsen title: Cytokine Blood Filtration Responses in COVID-19 date: 2020-05-28 journal: Blood Purif DOI: 10.1159/000508278 sha: doc_id: 295332 cord_uid: wlnss6bg file: cache/cord-294700-pb5k21da.json key: cord-294700-pb5k21da authors: Dulek, Daniel E; Fuhlbrigge, Robert C; Tribble, Alison C; Connelly, James A; Loi, Michele M; El Chebib, Hassan; Chandrakasan, Shanmuganathan; Otto, William R; Diorio, Caroline; Keim, Garrett; Walkovich, Kelly; Jaggi, Preeti; Girotto, Jennifer E; Yarbrough, April; Behrens, Edward M; Cron, Randy Q; Bassiri, Hamid title: Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute COVID-19 in Pediatric Patients date: 2020-08-18 journal: J Pediatric Infect Dis Soc DOI: 10.1093/jpids/piaa098 sha: doc_id: 294700 cord_uid: pb5k21da file: cache/cord-295323-snrt9odv.json key: cord-295323-snrt9odv authors: Yadav, Sandeep Kumar; Kar, Bikram Keshri; Banta, Aditya; Kumar, Awkash title: Creating Backup Management Resources for Spine Care during the Coronavirus Disease 2019 Pandemic date: 2020-05-14 journal: Asian Spine J DOI: 10.31616/asj.2020.0193 sha: doc_id: 295323 cord_uid: snrt9odv file: cache/cord-294593-mh1uh1b3.json key: cord-294593-mh1uh1b3 authors: Boloori, Alireza; Arnetz, Bengt B.; Viens, Frederi; Maiti, Taps; Arnetz, Judith E. title: Misalignment of Stakeholder Incentives in the Opioid Crisis date: 2020-10-16 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17207535 sha: doc_id: 294593 cord_uid: mh1uh1b3 file: cache/cord-294810-mq9vjnro.json key: cord-294810-mq9vjnro authors: Huang, Qiong; Deng, Xuanyu; Li, Yongzhong; Sun, Xuexiong; Chen, Qiong; Xie, Mingxuan; Liu, Shao; Qu, Hui; Liu, Shouxian; Wang, Ling; He, Gefei; Gong, Zhicheng title: Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China date: 2020-05-14 journal: Int J Clin Pharm DOI: 10.1007/s11096-020-01031-2 sha: doc_id: 294810 cord_uid: mq9vjnro file: cache/cord-295414-v10454ns.json key: cord-295414-v10454ns authors: Baktash, Vadir; Hosack, Tom; Patel, Nishil; Shah, Shital; Kandiah, Pirabakaran; Van Den Abbeele, Koenraad; Mandal, Amit K J; Missouris, Constantinos G title: Vitamin D status and outcomes for hospitalised older patients with COVID-19 date: 2020-08-26 journal: Postgrad Med J DOI: 10.1136/postgradmedj-2020-138712 sha: doc_id: 295414 cord_uid: v10454ns file: cache/cord-295371-ccqne6nu.json key: cord-295371-ccqne6nu authors: Stoj, Victoria J.; Grant-Kels, Jane M. title: Dermatology residents and the care of patients with coronavirus disease 2019 (COVID-19) date: 2020-04-04 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.03.086 sha: doc_id: 295371 cord_uid: ccqne6nu file: cache/cord-295144-tyyc81uc.json key: cord-295144-tyyc81uc authors: Stradner, Martin H.; Dejaco, Christian; Zwerina, Jochen; Fritsch-Stork, Ruth D. title: Rheumatic Musculoskeletal Diseases and COVID-19 A Review of the First 6 Months of the Pandemic date: 2020-10-09 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.562142 sha: doc_id: 295144 cord_uid: tyyc81uc file: cache/cord-295700-lzaxzuwe.json key: cord-295700-lzaxzuwe authors: Shi, Shaobo; Qin, Mu; Cai, Yuli; Liu, Tao; Shen, Bo; Yang, Fan; Cao, Sheng; Liu, Xu; Xiang, Yaozu; Zhao, Qinyan; Huang, He; Yang, Bo; Huang, Congxin title: Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 date: 2020-05-11 journal: Eur Heart J DOI: 10.1093/eurheartj/ehaa408 sha: doc_id: 295700 cord_uid: lzaxzuwe file: cache/cord-296018-lgx5k2kp.json key: cord-296018-lgx5k2kp authors: Lee, Jong-Bin; Shin, Hye-Jung; Kim, Dae-Yeob; Pang, Eun-Kyoung title: Evaluation of prognosis related to compliance with supportive periodontal treatment in patients with chronic periodontitis: a clinical retrospective study date: 2019-04-17 journal: J Periodontal Implant Sci DOI: 10.5051/jpis.2019.49.2.76 sha: doc_id: 296018 cord_uid: lgx5k2kp file: cache/cord-295800-w0dup04b.json key: cord-295800-w0dup04b authors: So, Loletta K-Y; Lau, Arthur CW; Yam, Loretta YC; Cheung, Thomas MT; Poon, Edwin; Yung, Raymond WH; Yuen, KY title: Development of a standard treatment protocol for severe acute respiratory syndrome date: 2003-05-10 journal: Lancet DOI: 10.1016/s0140-6736(03)13265-5 sha: doc_id: 295800 cord_uid: w0dup04b file: cache/cord-294788-9usyb1nn.json key: cord-294788-9usyb1nn authors: Baek, Woong Kee; Sohn, Soo-Yeon; Mahgoub, Ahmed; Hage, Robert title: A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 date: 2020-05-03 journal: Cureus DOI: 10.7759/cureus.7943 sha: doc_id: 294788 cord_uid: 9usyb1nn file: cache/cord-295971-jtv1jj2z.json key: cord-295971-jtv1jj2z authors: Cho, Sun Young; Kang, Ji-Man; Ha, Young Eun; Park, Ga Eun; Lee, Ji Yeon; Ko, Jae-Hoon; Lee, Ji Yong; Kim, Jong Min; Kang, Cheol-In; Jo, Ik Joon; Ryu, Jae Geum; Choi, Jong Rim; Kim, Seonwoo; Huh, Hee Jae; Ki, Chang-Seok; Kang, Eun-Suk; Peck, Kyong Ran; Dhong, Hun-Jong; Song, Jae-Hoon; Chung, Doo Ryeon; Kim, Yae-Jean title: MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study date: 2016-07-09 journal: Lancet DOI: 10.1016/s0140-6736(16)30623-7 sha: doc_id: 295971 cord_uid: jtv1jj2z file: cache/cord-296113-syi2fwuo.json key: cord-296113-syi2fwuo authors: Peng, Mian; Ren, Di; Liu, Yong-Feng; Meng, Xi; Wu, Ming; Chen, Rong-Lin; Yu, Bao-Jun; Tao, Long-Cheng; Chen, Li; Lai, Zeng-Qiao title: Two mechanically ventilated cases of COVID-19 successfully managed with a sequential ventilation weaning protocol: Two case reports date: 2020-08-06 journal: World J Clin Cases DOI: 10.12998/wjcc.v8.i15.3305 sha: doc_id: 296113 cord_uid: syi2fwuo file: cache/cord-296182-hhswage4.json key: cord-296182-hhswage4 authors: Meng, Lingzhong; Qiu, Haibo; Wan, Li; Ai, Yuhang; Xue, Zhanggang; Guo, Qulian; Deshpande, Ranjit; Zhang, Lina; Meng, Jie; Tong, Chuanyao; Liu, Hong; Xiong, Lize title: Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience date: 2020-04-08 journal: Anesthesiology DOI: 10.1097/aln.0000000000003296 sha: doc_id: 296182 cord_uid: hhswage4 file: cache/cord-295523-5pv7kw6i.json key: cord-295523-5pv7kw6i authors: Picchianti Diamanti, Andrea; Rosado, Maria Manuela; Pioli, Claudio; Sesti, Giorgio; Laganà, Bruno title: Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity date: 2020-05-08 journal: Int J Mol Sci DOI: 10.3390/ijms21093330 sha: doc_id: 295523 cord_uid: 5pv7kw6i file: cache/cord-295798-x7or932x.json key: cord-295798-x7or932x authors: Ferrey, Antoney J.; Choi, Grace; Hanna, Ramy M.; Chang, Yongen; Tantisattamo, Ekamol; Ivaturi, Kaushik; Park, Elisa; Nguyen, Lawrence; Wang, Brian; Tonthat, Sam; Rhee, Connie M.; Reddy, Uttam; Lau, Wei Ling; Huang, Susan S.; Gohil, Shruti; Amin, Alpesh N.; Hsieh, Lanny; Cheng, Timmy T.; Lee, Richard A.; Kalantar-Zadeh, Kamyar title: A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease date: 2020-03-28 journal: Am J Nephrol DOI: 10.1159/000507417 sha: doc_id: 295798 cord_uid: x7or932x file: cache/cord-295794-glcg36si.json key: cord-295794-glcg36si authors: Seghers, Victor J.; Desai, Nilesh K.; Masand, Prakash M.; Nasir, Sadia; Foster, Traci L.; Indiero, Dennis A.; Johnson, Trent D.; Huisman, Thierry A. G. M. title: After the initial COVID-19 surge: a phased radiology departmental re-opening plan date: 2020-08-22 journal: Pediatr Radiol DOI: 10.1007/s00247-020-04792-0 sha: doc_id: 295794 cord_uid: glcg36si file: cache/cord-296588-q2716lda.json key: cord-296588-q2716lda authors: Hanson, Kimberly E; Caliendo, Angela M; Arias, Cesar A; Englund, Janet A; Lee, Mark J; Loeb, Mark; Patel, Robin; El Alayli, Abdallah; Kalot, Mohamad A; Falck-Ytter, Yngve; Lavergne, Valery; Morgan, Rebecca L; Murad, M Hassan; Sultan, Shahnaz; Bhimraj, Adarsh; Mustafa, Reem A title: Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19 date: 2020-06-16 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa760 sha: doc_id: 296588 cord_uid: q2716lda file: cache/cord-296494-6kn4mr04.json key: cord-296494-6kn4mr04 authors: Saban-Ruiz, J.; Ly-Pen, D. title: COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs. The Role of Aging Beyond Topics date: 2020-05-12 journal: J Nutr Health Aging DOI: 10.1007/s12603-020-1385-5 sha: doc_id: 296494 cord_uid: 6kn4mr04 file: cache/cord-296562-3h2oqb9k.json key: cord-296562-3h2oqb9k authors: Guillén, Lucía; Padilla, Sergio; Fernández, Marta; Agulló, Vanesa; García, José Alberto; Telenti, Guillermo; García-Abellán, Javier; Botella, Ángela; Gutiérrez, Félix; Masiá, Mar title: Preemptive interleukin-6 blockade in patients with COVID-19 date: 2020-10-08 journal: Sci Rep DOI: 10.1038/s41598-020-74001-3 sha: doc_id: 296562 cord_uid: 3h2oqb9k file: cache/cord-296013-6ej3pd0u.json key: cord-296013-6ej3pd0u authors: Trinidad, John; Kroshinksy, Daniela; Kaffenberger, Benjamin H.; Rojek, Nathan title: Telemedicine for Inpatient Dermatology Consultations in Response to the COVID-19 Pandemic date: 2020-04-24 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.04.096 sha: doc_id: 296013 cord_uid: 6ej3pd0u file: cache/cord-296219-zzg9hds0.json key: cord-296219-zzg9hds0 authors: Battaglini, Denise; Brunetti, Iole; Anania, Pasquale; Fiaschi, Pietro; Zona, Gianluigi; Ball, Lorenzo; Giacobbe, Daniele Roberto; Vena, Antonio; Bassetti, Matteo; Patroniti, Nicolò; Schenone, Angelo; Pelosi, Paolo; Rocco, Patricia R. M.; Robba, Chiara title: Neurological Manifestations of Severe SARS-CoV-2 Infection: Potential Mechanisms and Implications of Individualized Mechanical Ventilation Settings date: 2020-08-12 journal: Front Neurol DOI: 10.3389/fneur.2020.00845 sha: doc_id: 296219 cord_uid: zzg9hds0 file: cache/cord-296605-p67twx7a.json key: cord-296605-p67twx7a authors: LAU, Arthur Chun-Wing; YAM, Loretta Yin-Chun; SO, Loletta Kit-Ying title: Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) date: 2004-03-10 journal: Int J Med Sci DOI: nan sha: doc_id: 296605 cord_uid: p67twx7a file: cache/cord-295703-no45mgyd.json key: cord-295703-no45mgyd authors: ALTAY, O.; YANG, H.; AYDIN, M.; Alkurt, G.; ALTUNAL, N.; KIM, W.; AKYOL, D.; ARIF, M.; Zhang, C.; Dinler-Doganay, G.; TURKEZ, H.; SHOAIE, S.; NIELSEN, J.; BOREN, J.; DOGANAY, L.; UHLEN, M.; Mardinoglu, A. title: Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date: 2020-10-05 journal: nan DOI: 10.1101/2020.10.02.20202614 sha: doc_id: 295703 cord_uid: no45mgyd file: cache/cord-296676-2anl2agl.json key: cord-296676-2anl2agl authors: Goldberg, Michael F.; Goldberg, Morton F. title: Neuroradiologic manifestations of COVID-19: what the emergency radiologist needs to know date: 2020-08-21 journal: Emerg Radiol DOI: 10.1007/s10140-020-01840-y sha: doc_id: 296676 cord_uid: 2anl2agl file: cache/cord-296331-i4hyzqcv.json key: cord-296331-i4hyzqcv authors: Adapa, Sreedhar; Chenna, Avantika; Balla, Mamtha; Merugu, Ganesh Prasad; Koduri, Narayana Murty; Daggubati, Subba Rao; Gayam, Vijay; Naramala, Srikanth; Konala, Venu Madhav title: COVID-19 Pandemic Causing Acute Kidney Injury and Impact on Patients With Chronic Kidney Disease and Renal Transplantation date: 2020-06-04 journal: J Clin Med Res DOI: 10.14740/jocmr4200 sha: doc_id: 296331 cord_uid: i4hyzqcv file: cache/cord-296694-2js639bk.json key: cord-296694-2js639bk authors: Price, Laura C; McCabe, Colm; Garfield, Ben; Wort, Stephen J title: Thrombosis and COVID-19 pneumonia: the clot thickens! date: 2020-06-18 journal: Eur Respir J DOI: 10.1183/13993003.01608-2020 sha: doc_id: 296694 cord_uid: 2js639bk file: cache/cord-296440-18vpg419.json key: cord-296440-18vpg419 authors: Beurnier, Antoine; Jutant, Etienne-Marie; Jevnikar, Mitja; Boucly, Athénaïs; Pichon, Jérémie; Preda, Mariana; Frank, Marie; Laurent, Jérémy; Richard, Christian; Monnet, Xavier; Duranteau, Jacques; Harrois, Anatole; Chaumais, Marie-Camille; Bellin, Marie-France; Noël, Nicolas; Bulifon, Sophie; Jaïs, Xavier; Parent, Florence; Seferian, Andrei; Savale, Laurent; Sitbon, Olivier; Montani, David; Humbert, Marc title: Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation date: 2020-07-30 journal: Eur Respir J DOI: 10.1183/13993003.01875-2020 sha: doc_id: 296440 cord_uid: 18vpg419 file: cache/cord-296607-h2zwlyz7.json key: cord-296607-h2zwlyz7 authors: Watson, Ryan A.; Johnson, Drew M.; Dharia, Robin N.; Merli, Geno J.; Doherty, John U. title: Anti-coagulant and anti-platelet therapy in the COVID-19 patient: a best practices quality initiative across a large health system date: 2020-06-09 journal: Hospital practice DOI: 10.1080/21548331.2020.1772639 sha: doc_id: 296607 cord_uid: h2zwlyz7 file: cache/cord-297127-nhgm09db.json key: cord-297127-nhgm09db authors: Hasseli, Rebecca; Mueller-Ladner, Ulf; Schmeiser, Tim; Hoyer, Bimba F; Krause, Andreas; Lorenz, Hanns-Martin; Regierer, Anne Constanze; Richter, Jutta G; Strangfeld, Anja; Voll, Reinhard E; Pfeil, Alexander; Schulze-Koops, Hendrik; Specker, Christof title: National registry for patients with inflammatory rheumatic diseases (IRD) infected with SARS-CoV-2 in Germany (ReCoVery): a valuable mean to gain rapid and reliable knowledge of the clinical course of SARS-CoV-2 infections in patients with IRD date: 2020-09-02 journal: RMD Open DOI: 10.1136/rmdopen-2020-001332 sha: doc_id: 297127 cord_uid: nhgm09db file: cache/cord-296881-2g81sjnl.json key: cord-296881-2g81sjnl authors: Nabil, Ahmed; Uto, Koichiro; Elshemy, Mohamed M.; Soliman, Reham; Hassan, Ayman A.; Ebara, Mitsuhiro; Shiha, Gamal title: Current coronavirus (SARS-CoV-2) epidemiological, diagnostic and therapeutic approaches: An updated review until June 2020 date: 2020-07-20 journal: EXCLI J DOI: 10.17179/excli2020-2554 sha: doc_id: 296881 cord_uid: 2g81sjnl file: cache/cord-297132-lhfa9fl5.json key: cord-297132-lhfa9fl5 authors: Aghagoli, Ghazal; Gallo Marin, Benjamin; Katchur, Nicole J.; Chaves-Sell, Franz; Asaad, Wael F.; Murphy, Sarah A. title: Neurological Involvement in COVID-19 and Potential Mechanisms: A Review date: 2020-07-13 journal: Neurocrit Care DOI: 10.1007/s12028-020-01049-4 sha: doc_id: 297132 cord_uid: lhfa9fl5 file: cache/cord-297208-f4ob3ox6.json key: cord-297208-f4ob3ox6 authors: Pisano, Antonio; Landoni, Giovanni; Verniero, Luigi; Zangrillo, Alberto title: Cardiothoracic surgery at the time of COVID-19 pandemic: lessons from the East (and from a previous epidemic) for western battlefields date: 2020-05-06 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.04.051 sha: doc_id: 297208 cord_uid: f4ob3ox6 file: cache/cord-297138-t8b3914h.json key: cord-297138-t8b3914h authors: Duijker, G.; Bertsias, A.; Symvoulakis, E. K.; Moschandreas, J.; Malliaraki, N.; Derdas, S. P.; Tsikalas, G. K.; Katerinopoulos, H. E.; Pirintsos, S. A.; Sourvinos, G.; Castanas, E.; Lionis, C. title: Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection: Results from a double-blind randomized controlled trial date: 2015-04-02 journal: Journal of Ethnopharmacology DOI: 10.1016/j.jep.2015.01.030 sha: doc_id: 297138 cord_uid: t8b3914h file: cache/cord-297093-ld89vmct.json key: cord-297093-ld89vmct authors: Clark, Kristina E N; Collas, Oliver; Lachmann, Helen; Singh, Animesh; Buckley, Jim; Bhagani, Sanjay title: Safety of intravenous Anakinra in COVID-19 with evidence of hyperinflammation, a case series date: 2020-08-04 journal: Rheumatol Adv Pract DOI: 10.1093/rap/rkaa040 sha: doc_id: 297093 cord_uid: ld89vmct file: cache/cord-297327-19dfgfz6.json key: cord-297327-19dfgfz6 authors: Drożdżal, Sylwester; Rosik, Jakub; Lechowicz, Kacper; Machaj, Filip; Szostak, Bartosz; Majewski, Paweł; Rotter, Iwona; Kotfis, Katarzyna title: COVID-19: Pain Management in Patients with SARS-CoV-2 Infection—Molecular Mechanisms, Challenges, and Perspectives date: 2020-07-20 journal: Brain Sci DOI: 10.3390/brainsci10070465 sha: doc_id: 297327 cord_uid: 19dfgfz6 file: cache/cord-297532-ktiwfcop.json key: cord-297532-ktiwfcop authors: De Fata Salvatores, Gaia; Villani, Alessia; Fabbrocini, Gabriella; Di Guida, Adriana title: Patients with bullous disorders during COVID‐19 period: management and adherence to treatment date: 2020-05-26 journal: Dermatol Ther DOI: 10.1111/dth.13697 sha: doc_id: 297532 cord_uid: ktiwfcop file: cache/cord-297638-ab70s980.json key: cord-297638-ab70s980 authors: Stephens, Angela J.; Barton, John R.; Bentum, Nana-Ama Ankumah; Blackwell, Sean C.; Sibai, Baha M. title: General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic date: 2020-04-28 journal: Am J Perinatol DOI: 10.1055/s-0040-1710308 sha: doc_id: 297638 cord_uid: ab70s980 file: cache/cord-297832-picpuzvo.json key: cord-297832-picpuzvo authors: Salazar, Rafael; Hallo, Alejandro; Vasquez, Sebastian; Reinthaller, Steffy; Echeverria, Juan title: Decreased Mortality in Patients With Severe Bronchospasm Associated With SARS-CoV-2: An Alternative to Invasive Mechanical Ventilation date: 2020-10-06 journal: Cureus DOI: 10.7759/cureus.10822 sha: doc_id: 297832 cord_uid: picpuzvo file: cache/cord-296773-5o4hr6ir.json key: cord-296773-5o4hr6ir authors: Zeneli, A.; Altini, M.; Bragagni, M.; Gentili, N.; Prati, S.; Golinucci, M.; Rustignoli, M.; Montalti, S. title: Mitigating strategies and nursing response for cancer care management during the COVID‐19 pandemic: an Italian experience date: 2020-10-02 journal: Int Nurs Rev DOI: 10.1111/inr.12625 sha: doc_id: 296773 cord_uid: 5o4hr6ir file: cache/cord-297759-arg71du6.json key: cord-297759-arg71du6 authors: Triantafyllou, Tania; Olson, Michael T.; Theodorou, Dimitrios; Zografos, Georgios; Singhal, Saurabh title: Esophageal cancer: challenges, concerns, and recommendations for management amidst the COVID-19 pandemic date: 2020-06-22 journal: Ann Gastroenterol DOI: 10.20524/aog.2020.0519 sha: doc_id: 297759 cord_uid: arg71du6 file: cache/cord-296936-5gkx4jxa.json key: cord-296936-5gkx4jxa authors: An, M. H.; Kim, M. S.; park, Y.; Kim, B.-O.; Kang, S. H.; Kimn, W. J.; Park, S. K.; Park, H.-W.; Yang, W.; Jang, J.; Jang, S.; Hwang, T.-H. title: Treatment Response to Hydroxychloroquine and Antibiotics for mild to moderate COVID-19: a retrospective cohort study from South Korea date: 2020-07-07 journal: nan DOI: 10.1101/2020.07.04.20146548 sha: doc_id: 296936 cord_uid: 5gkx4jxa file: cache/cord-297414-zq16s9ud.json key: cord-297414-zq16s9ud authors: Koh, Adrian H. C.; Koh, Luke R. S.; Sheu, Shwu-Jiuan; Sakamoto, Taiji title: What COVID-19 has taught us: lessons from around the globe date: 2020-06-13 journal: Graefes Arch Clin Exp Ophthalmol DOI: 10.1007/s00417-020-04791-9 sha: doc_id: 297414 cord_uid: zq16s9ud file: cache/cord-297494-6yxmaihl.json key: cord-297494-6yxmaihl authors: Katsurada, Naoko; Suzuki, Motoi; Aoshima, Masahiro; Yaegashi, Makito; Ishifuji, Tomoko; Asoh, Norichika; Hamashige, Naohisa; Abe, Masahiko; Ariyoshi, Koya; Morimoto, Konosuke title: The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study date: 2017-12-06 journal: BMC Infect Dis DOI: 10.1186/s12879-017-2858-y sha: doc_id: 297494 cord_uid: 6yxmaihl file: cache/cord-297836-y9vt6wvu.json key: cord-297836-y9vt6wvu authors: Tan, Yi Quan; Lu, Jirong; Chiong, Edmund title: Re: Kristian D. Stensland, Todd M. Morgan, Alireza Moinzadeh, et al. Considerations in the Triage of Urologic Surgeries During the COVID-19 Pandemic. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.027: The Forgotten Urological Patient During the COVID-19 Pandemic: Patient Safety Safeguards date: 2020-05-08 journal: Eur Urol DOI: 10.1016/j.eururo.2020.04.072 sha: doc_id: 297836 cord_uid: y9vt6wvu file: cache/cord-298067-awo3smgp.json key: cord-298067-awo3smgp authors: Li, Huanjie; Wang, Yangyang; Ji, Mingyu; Pei, Fengyan; Zhao, Qianqian; Zhou, Yunying; Hong, Yatian; Han, Shuyi; Wang, Jun; Wang, Qingxi; Li, Qiang; Wang, Yunshan title: Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report date: 2020-07-10 journal: Front Cell Dev Biol DOI: 10.3389/fcell.2020.00618 sha: doc_id: 298067 cord_uid: awo3smgp file: cache/cord-297001-4g3wb8qi.json key: cord-297001-4g3wb8qi authors: Tal, Shir; Spectre, Galia; Kornowski, Ran; Perl, Leor title: Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? date: 2020-05-12 journal: Acta Haematol DOI: 10.1159/000508233 sha: doc_id: 297001 cord_uid: 4g3wb8qi file: cache/cord-298325-2gm4fnqi.json key: cord-298325-2gm4fnqi authors: Shah, Sonia; Majmudar, Kaushal; Stein, Amy; Gupta, Nita; Suppes, Spencer; Karamanis, Marina; Capannari, Joseph; Sethi, Sanjay; Patte, Christine title: Novel use of home pulse oximetry monitoring in COVID‐19 patients discharged from the emergency department identifies need for hospitalization date: 2020-06-17 journal: Acad Emerg Med DOI: 10.1111/acem.14053 sha: doc_id: 298325 cord_uid: 2gm4fnqi file: cache/cord-298034-0ntxm28a.json key: cord-298034-0ntxm28a authors: Tepper, Joel E. title: Ethical Issues in Radiation Oncology During a Pandemic date: 2020-05-22 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.04.037 sha: doc_id: 298034 cord_uid: 0ntxm28a file: cache/cord-298516-0eda4mzs.json key: cord-298516-0eda4mzs authors: Fadlallah, Ali; Khattar, Georges; Habre, Charbel; Khanafer, Dana title: LASIK procedures during COVID-19 date: 2020-08-05 journal: J Cataract Refract Surg DOI: 10.1097/j.jcrs.0000000000000338 sha: doc_id: 298516 cord_uid: 0eda4mzs file: cache/cord-297506-1xjgsz4y.json key: cord-297506-1xjgsz4y authors: Jansen, Jaclyn H.; Day, Rachel L. title: A novel presentation of COVID-19 via community acquired infection date: 2020-03-31 journal: Vis J Emerg Med DOI: 10.1016/j.visj.2020.100760 sha: doc_id: 297506 cord_uid: 1xjgsz4y file: cache/cord-297518-6y2uzcde.json key: cord-297518-6y2uzcde authors: Leulseged, T. W.; Alemahu, D. G.; Hassen, I. S.; Maru, E. H.; Zewde, W. C.; Chamesew, N. W.; Yegile, K. T.; Abebe, D. S.; Abdi, F. M.; Menyelshewa, E. Y.; Gerbi, T. G.; Hagos, H. T. title: Determinants of Developing Symptomatic Disease in Ethiopian COVID-19 Patients date: 2020-10-13 journal: nan DOI: 10.1101/2020.10.09.20209734 sha: doc_id: 297518 cord_uid: 6y2uzcde file: cache/cord-298679-w0yp4u19.json key: cord-298679-w0yp4u19 authors: Iftimie, Simona; López-Azcona, Ana F.; Vicente-Miralles, Manuel; Descarrega-Reina, Ramon; Hernández-Aguilera, Anna; Riu, Francesc; Simó, Josep M.; Garrido, Pedro; Joven, Jorge; Camps, Jordi; Castro, Antoni title: Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain date: 2020-09-03 journal: PLoS One DOI: 10.1371/journal.pone.0234452 sha: doc_id: 298679 cord_uid: w0yp4u19 file: cache/cord-297425-vcqqssm8.json key: cord-297425-vcqqssm8 authors: Aries, James A.; Davies, Jeffrey K.; Auer, Rebecca L.; Hallam, Simon L.; Montoto, Silvia; Smith, Matthew; Sevillano, Belen; Foggo, Vanessa; Wrench, Bela; Zegocki, Krzysztof; Agrawal, Samir; Le Dieu, Rifca; Truelove, Edward; Erblich, Thomas; Araf, Shamzah; Okosun, Jessica; Oakervee, Heather; Cavenagh, Jamie D.; Gribben, John G.; Riches, John C. title: Clinical Outcome of Coronavirus Disease 2019 in Haemato‐oncology Patients date: 2020-05-18 journal: Br J Haematol DOI: 10.1111/bjh.16852 sha: doc_id: 297425 cord_uid: vcqqssm8 file: cache/cord-297840-z5l6vdsr.json key: cord-297840-z5l6vdsr authors: Río, Francisco García; Clau, Luis Borderías; Macario, Ciro Casanova; Celli, Bartolomé R.; Sanglás, Joan Escarrabill; Mangado, Nicolás González; Torrent, Josep Roca; Romero, Fernando Uresandi title: Air Travel and Respiratory Disease date: 2007-02-28 journal: Archivos de Bronconeumología ((English Edition)) DOI: 10.1016/s1579-2129(07)60031-7 sha: doc_id: 297840 cord_uid: z5l6vdsr file: cache/cord-298094-ctikhqvr.json key: cord-298094-ctikhqvr authors: Elias, Pierre; Poterucha, Timothy J.; Jain, Sneha S.; Sayer, Gabriel; Raikhelkar, Jayant; Fried, Justin; Clerkin, Kevin; Griffin, Jan; DeFilippis, Ersilia M.; Gupta, Aakriti; Lawlor, Matthew; Madhavan, Mahesh; Rosenblum, Hannah; Roth, Zachary B.; Natarajan, Karthik; Hripcsak, George; Perotte, Adler; Wan, Elaine Y.; Saluja, Deepak; Dizon, Jose; Ehlert, Frederick; Morrow, John P.; Yarmohammadi, Hirad; Kumaraiah, Deepa; Redfors, Bjorn; Gavin, Nicholas; Kirtane, Ajay; Rabbani, Leroy; Burkhoff, Dan; Moses, Jeffrey; Schwartz, Allan; Leon, Martin; Uriel, Nir title: The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19 date: 2020-08-15 journal: Mayo Clin Proc DOI: 10.1016/j.mayocp.2020.07.028 sha: doc_id: 298094 cord_uid: ctikhqvr file: cache/cord-298403-ilpzj2sv.json key: cord-298403-ilpzj2sv authors: Mintz, Yoav; Arezzo, Alberto; Boni, Luigi; Baldari, Ludovica; Cassinotti, Elisa; Brodie, Ronit; Uranues, Selman; Zheng, MinHua; Fingerhut, Abe title: Minimally Invasive Surgery is the Key to Patient and Operating room team Safety During the COVID19 Pandemic as well as in the “new normal” or chronic Pandemic State to come date: 2020-08-18 journal: Br J Surg DOI: 10.1002/bjs.11916 sha: doc_id: 298403 cord_uid: ilpzj2sv file: cache/cord-298056-svwtfshi.json key: cord-298056-svwtfshi authors: Fabio, Ciceri; Antonella, Castagna; Patrizia, Rovere-Querini; Francesco, De Cobelli; Annalisa, Ruggeri; Laura, Galli; Caterina, Conte; Rebecca, De Lorenzo; Andrea, Poli; Alberto, Ambrosio; Carlo, Signorelli; Eleonora, Bossi; Maria, Fazio; Cristina, Tresoldi; Sergio, Colombo; Giacomo, Monti; Efgeny, Fominskiy; Stefano, Franchini; Marzia, Spessot; Carlo, Martinenghi; Michele, Carlucci; Luigi, Beretta; Maria, Scandroglio Anna; Massimo, Clementi; Massimo, Locatelli; Moreno, Tresoldi; Paolo, Scarpellini; Gianvito, Martino; Emanuele, Bosi; Lorenzo, Dagna; Adriano, Lazzarin; Giovanni, Landoni; Alberto, Zangrillo title: Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy date: 2020-06-12 journal: Clin Immunol DOI: 10.1016/j.clim.2020.108509 sha: doc_id: 298056 cord_uid: svwtfshi file: cache/cord-298787-4vo9gpiu.json key: cord-298787-4vo9gpiu authors: Frost, Holly M.; Robinson, Christine C.; Dominguez, Samuel R. title: Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1–3 date: 2013-10-16 journal: The Journal of Infectious Diseases DOI: 10.1093/infdis/jit552 sha: doc_id: 298787 cord_uid: 4vo9gpiu file: cache/cord-298894-t5hyfum3.json key: cord-298894-t5hyfum3 authors: Rifino, Nicola; Censori, Bruno; Agazzi, Emanuela; Alimonti, Dario; Bonito, Virginio; Camera, Giorgia; Conti, Marta Zaffira; Foresti, Camillo; Frigeni, Barbara; Gerevini, Simonetta; Grimoldi, Maria; La Gioia, Sara; Partziguian, Tania; Quadri, Stefano; Riva, Riccardo; Servalli, Maria Cristina; Sgarzi, Manlio; Storti, Benedetta; Vedovello, Marcella; Venturelli, Elisabetta; Viganò, Martina; Callegaro, Annapaola; Arosio, Marco; Sessa, Maria title: Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy date: 2020-10-07 journal: J Neurol DOI: 10.1007/s00415-020-10251-5 sha: doc_id: 298894 cord_uid: t5hyfum3 file: cache/cord-299024-jkqdzt87.json key: cord-299024-jkqdzt87 authors: Mangner, Norman; Sveric, Krunoslav; Gerber, Johannes C.; Svitil, Jan; Linke, Axel; Jellinghaus, Stefanie title: Paraneoplastic syndrome and SARS-CoV-2 – incremental effect of two thrombogenic conditions? date: 2020-10-21 journal: CJC Open DOI: 10.1016/j.cjco.2020.10.010 sha: doc_id: 299024 cord_uid: jkqdzt87 file: cache/cord-298967-vjyh1xvh.json key: cord-298967-vjyh1xvh authors: Bertossi, Dario; Mohsahebi, Ash; Philippe Dormstrom,; Heidenrich, Izolda; Pirayesh, Ali; D’Souza, Alwyn; Saleh, Hesham; Yavuzer, Rezha; Fakih, Nabil; Vent, Julia; Rahman, Eqram; Kapoor, Krishan Mohan title: Safety guidelines for non‐surgical facial procedures during covid‐19 outbreak date: 2020-06-07 journal: J Cosmet Dermatol DOI: 10.1111/jocd.13530 sha: doc_id: 298967 cord_uid: vjyh1xvh file: cache/cord-297870-m7n43k4p.json key: cord-297870-m7n43k4p authors: Azevedo, Rafael Bellotti; Botelho, Bruna Gopp; Hollanda, João Victor Gonçalves de; Ferreira, Leonardo Villa Leão; Junqueira de Andrade, Letícia Zarur; Oei, Stephanie Si Min Lilienwald; Mello, Tomás de Souza; Muxfeldt, Elizabeth Silaid title: Covid-19 and the cardiovascular system: a comprehensive review date: 2020-07-27 journal: J Hum Hypertens DOI: 10.1038/s41371-020-0387-4 sha: doc_id: 297870 cord_uid: m7n43k4p file: cache/cord-298974-69xjc5yq.json key: cord-298974-69xjc5yq authors: Adegboye, Oyelola A.; Elfaki, Faiz title: Network Analysis of MERS Coronavirus within Households, Communities, and Hospitals to Identify Most Centralized and Super-Spreading in the Arabian Peninsula, 2012 to 2016 date: 2018-05-07 journal: Can J Infect Dis Med Microbiol DOI: 10.1155/2018/6725284 sha: doc_id: 298974 cord_uid: 69xjc5yq file: cache/cord-299082-s8bm40vy.json key: cord-299082-s8bm40vy authors: Wang, Yueying; Wang, Zhaojia; Tse, Gary; Zhang, Lin; Wan, Elaine Y.; Guo, Yutao; Lip, Gregory Y. H.; Li, Guangping; Lu, Zhibing; Liu, Tong title: Cardiac arrhythmias in patients with COVID‐19 date: 2020-07-26 journal: J Arrhythm DOI: 10.1002/joa3.12405 sha: doc_id: 299082 cord_uid: s8bm40vy file: cache/cord-299681-smhto9em.json key: cord-299681-smhto9em authors: Elsaie, Mohamed L.; Youssef, Eman A.; Nada, Hesham A. title: Herpes zoster might be an indicator for Latent COVID 19 infection date: 2020-05-23 journal: Dermatol Ther DOI: 10.1111/dth.13666 sha: doc_id: 299681 cord_uid: smhto9em file: cache/cord-299489-6v225vte.json key: cord-299489-6v225vte authors: Gómez-Hernández, María Teresa; Novoa, Nuria M.; Antúnez, Patricia; Jiménez, Marcelo F. title: TWICE LUCKY: ELDERLY PATIENT SURVIVING BOTH COVID-19 AND SERENDIPITOUS LUNG CARCINOMA date: 2020-07-25 journal: Arch Bronconeumol DOI: 10.1016/j.arbres.2020.07.009 sha: doc_id: 299489 cord_uid: 6v225vte file: cache/cord-299222-vmofcrim.json key: cord-299222-vmofcrim authors: Rivas‐Pollmar, María Isabel; Álvarez‐Román, María Teresa; Butta‐Coll, Nora V.; Martín Salces, Mónica; García‐Barcenilla, Sara; Jiménez‐Yuste, Victor title: Thromboprophylaxis in a patient with COVID‐19 and severe hemophilia A on emicizumab prophylaxis date: 2020-06-11 journal: J Thromb Haemost DOI: 10.1111/jth.14954 sha: doc_id: 299222 cord_uid: vmofcrim file: cache/cord-299570-1xz5r95f.json key: cord-299570-1xz5r95f authors: Martínez-García, M; Bal-Alvarado, M; Santos Guerra, F; Ares-Rico, R; Suárez-Gil, R; Rodríguez-Álvarez, A; Pérez-López, A; Casariego-Vales, E title: Telemedicina con telemonitorización en el seguimiento de pacientes con COVID-19 date: 2020-06-05 journal: Rev Clin Esp DOI: 10.1016/j.rce.2020.05.013 sha: doc_id: 299570 cord_uid: 1xz5r95f file: cache/cord-299124-g70v4crs.json key: cord-299124-g70v4crs authors: Lancaster, Elizabeth M.; Wu, Bian; Iannuzzi, James; Oskowitz, Adam; Gasper, Warren; Vartanian, Shant; Wick, Elizabeth; Hiramoto, Jade; Eichler, Charles; Lobo, Errol; Reyzelman, Alexander; Reilly, Linda; Sosa, Julie A.; Conte, Michael S. title: Impact of the COVID-19 pandemic on an academic vascular practice and a multi-disciplinary limb preservation program date: 2020-09-12 journal: J Vasc Surg DOI: 10.1016/j.jvs.2020.08.132 sha: doc_id: 299124 cord_uid: g70v4crs file: cache/cord-299333-qu0bmov5.json key: cord-299333-qu0bmov5 authors: Reddy, Gireesh B.; Greif, Dylan N.; Rodriguez, Jose; Best, Thomas M.; Greditzer, Harry G.; Jose, Jean title: Clinical Characteristics and Multisystem Imaging Findings of COVID-19: An Overview for Orthopedic Surgeons date: 2020-08-17 journal: HSS J DOI: 10.1007/s11420-020-09775-3 sha: doc_id: 299333 cord_uid: qu0bmov5 file: cache/cord-299156-1dwsm3ie.json key: cord-299156-1dwsm3ie authors: Shemer, Asaf; Einan-Lifshitz, Adi; Itah, Amir; Dubinsky-Pertzov, Biana; Pras, Eran; Hecht, Idan title: Ocular involvement in coronavirus disease 2019 (COVID-19): a clinical and molecular analysis date: 2020-09-14 journal: Int Ophthalmol DOI: 10.1007/s10792-020-01592-1 sha: doc_id: 299156 cord_uid: 1dwsm3ie file: cache/cord-299449-226dd23u.json key: cord-299449-226dd23u authors: Bernhardt, Denise; Wick, Wolfgang; Weiss, Stephanie E; Sahgal, Arjun; Lo, Simon S; Suh, John H; Chang, Eric L; Foote, Matthew; Perry, James; Meyer, Bernhard; Vajkoczy, Peter; Wen, Patrick Y; Straube, Christoph; Pigorsch, Steffi; Wilkens, Jan J; Combs, Stephanie E title: Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas date: 2020-05-05 journal: Neuro Oncol DOI: 10.1093/neuonc/noaa113 sha: doc_id: 299449 cord_uid: 226dd23u file: cache/cord-299835-92karhpl.json key: cord-299835-92karhpl authors: Ho, Khek Y.; Singh, Kamaljit S.; Habib, Abdulrazaq G.; Ong, Benjamin K.; Lim, Tow K.; Ooi, Eng E.; Sil, Bijon K.; Ling, Ai-Ee; Bai, Xin L.; Tambyah, Paul A. title: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore date: 2004-02-17 journal: J Infect Dis DOI: 10.1086/381558 sha: doc_id: 299835 cord_uid: 92karhpl file: cache/cord-300038-1fjb6b8e.json key: cord-300038-1fjb6b8e authors: Cantini, Fabrizio; Niccoli, Laura; Matarrese, Daniela; Nicastri, Emanuele; Stobbione, Paolo; Goletti, Delia title: Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact date: 2020-04-23 journal: J Infect DOI: 10.1016/j.jinf.2020.04.017 sha: doc_id: 300038 cord_uid: 1fjb6b8e file: cache/cord-299881-weptfpa2.json key: cord-299881-weptfpa2 authors: Halvachizadeh, Sascha; Teuben, Michel; Berk, Till; Neuhaus, Valentin; Pape, Hans-Christoph; Pfeifer, Roman title: The impact of SARS-CoV-2 (COVID-19) pandemic on trauma bay management and guideline adherence in a European level-one-trauma centre date: 2020-07-28 journal: Int Orthop DOI: 10.1007/s00264-020-04740-5 sha: doc_id: 299881 cord_uid: weptfpa2 file: cache/cord-299621-m4kdkmey.json key: cord-299621-m4kdkmey authors: Kumar, A.; Chaterjee, Souranshu title: Outbreak of Middle East respiratory syndrome coronavirus, Saudi Arabian experience date: 2017-08-31 journal: Current Medicine Research and Practice DOI: 10.1016/j.cmrp.2017.07.006 sha: doc_id: 299621 cord_uid: m4kdkmey file: cache/cord-300356-oorac5he.json key: cord-300356-oorac5he authors: Nair, Girish B.; Niederman, Michael S. title: Community-Acquired Pneumonia: An Unfinished Battle date: 2011-10-05 journal: Med Clin North Am DOI: 10.1016/j.mcna.2011.08.007 sha: doc_id: 300356 cord_uid: oorac5he file: cache/cord-299750-zkrlm3ds.json key: cord-299750-zkrlm3ds authors: Cui, Wei; Zhao, Hongwen; Lu, Xu; Wen, Ying; Zhou, Ying; Deng, Baocheng; Wang, Yu; Wang, Wen; Kang, Jian; Liu, Pei title: Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China date: 2010-05-31 journal: BMC Infect Dis DOI: 10.1186/1471-2334-10-145 sha: doc_id: 299750 cord_uid: zkrlm3ds file: cache/cord-299254-kqpnwkg5.json key: cord-299254-kqpnwkg5 authors: Sun, Yingcheng; Guo, Fei; Kaffashi, Farhad; Jacono, Frank J.; DeGeorgia, Michael; Loparo, Kenneth A. title: INSMA: An integrated system for multimodal data acquisition and analysis in the intensive care unit date: 2020-04-28 journal: J Biomed Inform DOI: 10.1016/j.jbi.2020.103434 sha: doc_id: 299254 cord_uid: kqpnwkg5 file: cache/cord-300344-57vxlctl.json key: cord-300344-57vxlctl authors: Roof, Kevin S.; Butler, Jerome M.; Thakkar, Vipul V.; Doline, Robert M.; Kuremsky, Jeffrey G.; Konefal, John B.; McCammon, Robert J. title: Virtual On Treatment Visits: Implementation, Patient Perspectives, Barriers, Limitations, Benefits and Opportunities. date: 2020-10-16 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.09.019 sha: doc_id: 300344 cord_uid: 57vxlctl file: cache/cord-299679-6z9e5gi6.json key: cord-299679-6z9e5gi6 authors: Rello, Jordi; Storti, Enrico; Belliato, Mirko; Serrano, Ricardo title: Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers date: 2020-05-21 journal: Eur Respir J DOI: 10.1183/13993003.01028-2020 sha: doc_id: 299679 cord_uid: 6z9e5gi6 file: cache/cord-299784-xxxdjfbc.json key: cord-299784-xxxdjfbc authors: Bettari, Luca; Pero, Gaetano; Maiandi, Cristian; Messina, Antonio; Saccocci, Matteo; Cirillo, Marco; Troise, Giovanni; Conti, Elena; Cuccia, Claudio; Maffeo, Diego title: Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting date: 2020-04-10 journal: JACC Case Rep DOI: 10.1016/j.jaccas.2020.03.006 sha: doc_id: 299784 cord_uid: xxxdjfbc file: cache/cord-300044-vn4c6wh7.json key: cord-300044-vn4c6wh7 authors: Kim, Ji Won title: From White Count to White Out() date: 2015-08-05 journal: Clin Pediatr Emerg Med DOI: 10.1016/j.cpem.2015.08.002 sha: doc_id: 300044 cord_uid: vn4c6wh7 file: cache/cord-300995-tqz2bkdo.json key: cord-300995-tqz2bkdo authors: Tagliaferri, Luca; Di Stefani, Alessandro; Schinzari, Giovanni; Fionda, Bruno; Rossi, Ernesto; Del Regno, Laura; Gentileschi, Stefano; Federico, Francesco; Valentini, Vincenzo; Tortora, Giampaolo; Peris, Ketty title: Skin cancer triage and management during COVID‐19 pandemic date: 2020-04-25 journal: J Eur Acad Dermatol Venereol DOI: 10.1111/jdv.16529 sha: doc_id: 300995 cord_uid: tqz2bkdo file: cache/cord-300608-eju7wnb9.json key: cord-300608-eju7wnb9 authors: Sheervalilou, Roghayeh; Shirvaliloo, Milad; Dadashzadeh, Nahid; Shirvalilou, Sakine; Shahraki, Omolbanin; Pilehvar‐Soltanahmadi, Younes; Ghaznavi, Habib; Khoei, Samideh; Nazarlou, Ziba title: COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease date: 2020-05-26 journal: J Cell Physiol DOI: 10.1002/jcp.29735 sha: doc_id: 300608 cord_uid: eju7wnb9 file: cache/cord-300774-5mrkmctl.json key: cord-300774-5mrkmctl authors: Hernández-Mora, Miguel Górgolas; Cabello Úbeda, Alfonso; Pérez, Laura Prieto; Álvarez, Felipe Villar; Álvarez, Beatriz Álvarez; Rodríguez Nieto, María Jesús; Acosta, Irene Carrillo; Ormaechea, Itziar Fernández; Al-Hayani, Aws Waleed Mohammed; Carballosa, Pilar; Martínez, Silvia Calpena; Ezzine, Farah; González, Marina Castellanos; Naya, Alba; de las Heras, Marta López; Rodríguez Guzmán, Marcel José; Guijarro, Ana Cordero; Lavado, Antonio Broncano; Valcayo, Alicia Macías; García, Marta Martín; Martínez, Javier Bécares; Roblas, Ricardo Fernández; Piris Pinilla, Miguel Ángel; Alen, José Fortes; Pernaute, Olga Sánchez; Bueno, Fredeswinda Romero; Frades, Sarah Heili; Romero, Germán Peces Barba title: Compassionate Use of Tocilizumab in Severe SARS-CoV2 Pneumonia date: 2020-10-25 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.10.045 sha: doc_id: 300774 cord_uid: 5mrkmctl file: cache/cord-300559-vuuxthx2.json key: cord-300559-vuuxthx2 authors: Deng, Ming; Qi, Yongjian; Deng, Liping; Wang, Huawei; Xu, Yancheng; Li, Zhen; Meng, Zhe; Tang, Jun; Dai, Zhe title: Obesity as a Potential Predictor of Disease Severity in Young COVID‐19 Patients: A Retrospective Study date: 2020-06-29 journal: Obesity (Silver Spring) DOI: 10.1002/oby.22943 sha: doc_id: 300559 cord_uid: vuuxthx2 file: cache/cord-300866-cso6l6ze.json key: cord-300866-cso6l6ze authors: Bao, Yi; Lin, Shu Yu; Cheng, Zhao Hui; Xia, Jun; Sun, Yan Peng; Zhao, Qi; Liu, Guang Jian title: Clinical Features of COVID-19 in a Young Man with Massive Cerebral Hemorrhage—Case Report date: 2020-05-23 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00315-y sha: doc_id: 300866 cord_uid: cso6l6ze file: cache/cord-301011-xbuqd0j5.json key: cord-301011-xbuqd0j5 authors: Felten-Barentsz, Karin M; van Oorsouw, Roel; Klooster, Emily; Koenders, Niek; Driehuis, Femke; Hulzebos, Erik H J; van der Schaaf, Marike; Hoogeboom, Thomas J; van der Wees, Philip J title: Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19 date: 2020-06-18 journal: Phys Ther DOI: 10.1093/ptj/pzaa114 sha: doc_id: 301011 cord_uid: xbuqd0j5 file: cache/cord-299346-f13xly6q.json key: cord-299346-f13xly6q authors: Awad, Mohamed E.; Rumley, Jacob C.L.; Vazquez, Jose A.; Devine, John G. title: Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed Coronavirus Disease 2019 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current Coronavirus Disease 2019 Pandemic date: 2020-04-10 journal: J Am Acad Orthop Surg DOI: 10.5435/jaaos-d-20-00227 sha: doc_id: 299346 cord_uid: f13xly6q file: cache/cord-300183-z3fwtwqb.json key: cord-300183-z3fwtwqb authors: Ahmed, Taha; Lodhi, Samra Haroon; Kapadia, Samir; Shah, Gautam V title: Community and healthcare system-related factors feeding the phenomenon of evading medical attention for time-dependent emergencies during COVID-19 crisis date: 2020-08-25 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-237817 sha: doc_id: 300183 cord_uid: z3fwtwqb file: cache/cord-300510-fhpkdqr0.json key: cord-300510-fhpkdqr0 authors: Mojoli, Francesco; Mongodi, Silvia; Orlando, Anita; Arisi, Eric; Pozzi, Marco; Civardi, Luca; Tavazzi, Guido; Baldanti, Fausto; Bruno, Raffaele; Iotti, Giorgio Antonio title: Our recommendations for acute management of COVID-19 date: 2020-05-08 journal: Crit Care DOI: 10.1186/s13054-020-02930-6 sha: doc_id: 300510 cord_uid: fhpkdqr0 file: cache/cord-300697-p96i25uc.json key: cord-300697-p96i25uc authors: Chen, Taojiang; Yang, Qin; Duan, Hongyu title: A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report date: 2020-09-29 journal: BMC Gastroenterol DOI: 10.1186/s12876-020-01458-x sha: doc_id: 300697 cord_uid: p96i25uc file: cache/cord-300458-jeuwaj50.json key: cord-300458-jeuwaj50 authors: Maisch, Bernhard; Dörr, Rolf title: COVID-19—What we know and what we need to know: There are more questions than answers date: 2020-04-23 journal: Herz DOI: 10.1007/s00059-020-04929-9 sha: doc_id: 300458 cord_uid: jeuwaj50 file: cache/cord-300080-l0fyxtva.json key: cord-300080-l0fyxtva authors: Venkat, Arvind; Wolf, Lisa; Geiderman, Joel M.; Asher, Shellie L.; Marco, Catherine A.; McGreevy, Jolion; Derse, Arthur R.; Otten, Edward J.; Jesus, John E.; Kreitzer, Natalie P.; Escalante, Monica; Levine, Adam C. title: Ethical Issues in the Response to Ebola Virus Disease in US Emergency Departments: A Position Paper of the American College of Emergency Physicians, the Emergency Nurses Association and the Society for Academic Emergency Medicine date: 2015-03-10 journal: J Emerg Nurs DOI: 10.1016/j.jen.2015.01.012 sha: doc_id: 300080 cord_uid: l0fyxtva file: cache/cord-300303-d4qmtysd.json key: cord-300303-d4qmtysd authors: de Azambuja, Evandro; Trapani, Dario; Loibl, Sibylle; Delaloge, Suzette; Senkus, Elzbieta; Criscitiello, Carmen; Poortman, Philip; Gnant, Michael; Di Cosimo, Serena; Cortes, Javier; Cardoso, Fatima; Paluch-Shimon, Shani; Curigliano, Giuseppe title: ESMO Management and treatment adapted recommendations in the COVID-19 era: Breast Cancer date: 2020-05-20 journal: ESMO Open DOI: 10.1136/esmoopen-2020-000793 sha: doc_id: 300303 cord_uid: d4qmtysd file: cache/cord-300445-qzu4gz2d.json key: cord-300445-qzu4gz2d authors: Zhang, Xiao-lei; Li, Zhuo-ming; Ye, Jian-tao; Lu, Jing; Ye, Lingyu Linda; Zhang, Chun-xiang; Liu, Pei-qing; Duan, Dayue D title: Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives date: 2020-09-23 journal: Acta Pharmacol Sin DOI: 10.1038/s41401-020-00519-x sha: doc_id: 300445 cord_uid: qzu4gz2d file: cache/cord-301079-n1nytr6k.json key: cord-301079-n1nytr6k authors: Tan, Li; Ma, Boyi; Lai, Xiaoquan; Han, Lefei; Cao, Peihua; Zhang, Junji; Fu, Jianguo; Zhou, Qian; Wei, Shiqing; Wang, Zhenling; Peng, Weijun; Yang, Lin; Zhang, Xinping title: Air and surface contamination by SARS-CoV-2 virus in a tertiary hospital in Wuhan, China date: 2020-07-27 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.07.027 sha: doc_id: 301079 cord_uid: n1nytr6k file: cache/cord-301281-yur5hs2h.json key: cord-301281-yur5hs2h authors: Zelek, Wioleta M.; Cole, Jade; Ponsford, Mark J.; Harrison, Richard A.; Schroeder, Ben E.; Webb, Nicholas; Jolles, Stephen; Fegan, Christopher; Morgan, Matt; Wise, Matt P.; Morgan, B. Paul title: Complement Inhibition with the C5 Blocker LFG316 in Severe COVID-19 date: 2020-11-01 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202007-2778le sha: doc_id: 301281 cord_uid: yur5hs2h file: cache/cord-301391-5dvf1mi0.json key: cord-301391-5dvf1mi0 authors: Islam, Md. Milon; Ullah, Shah Muhammad Azmat; Mahmud, Saifuddin; Raju, S. M. Taslim Uddin title: Breathing Aid Devices to Support Novel Coronavirus (COVID-19)Infected Patients date: 2020-08-19 journal: SN COMPUT DOI: 10.1007/s42979-020-00300-1 sha: doc_id: 301391 cord_uid: 5dvf1mi0 file: cache/cord-301342-ikvpkhfp.json key: cord-301342-ikvpkhfp authors: Xue, Katherine S; Stevens-Ayers, Terry; Campbell, Angela P; Englund, Janet A; Pergam, Steven A; Boeckh, Michael; Bloom, Jesse D title: Parallel evolution of influenza across multiple spatiotemporal scales date: 2017-06-27 journal: eLife DOI: 10.7554/elife.26875 sha: doc_id: 301342 cord_uid: ikvpkhfp file: cache/cord-300811-l4y7df2f.json key: cord-300811-l4y7df2f authors: Aggarwal, Gaurav; Cheruiyot, Isaac; Aggarwal, Saurabh; Wong, Johnny; Lippi, Giuseppe; Lavie, Carl J.; Henry, Brandon M.; Sanchis-Gomar, Fabian title: Association of Cardiovascular Disease with Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis date: 2020-04-28 journal: Curr Probl Cardiol DOI: 10.1016/j.cpcardiol.2020.100617 sha: doc_id: 300811 cord_uid: l4y7df2f file: cache/cord-301087-9vl5pqi7.json key: cord-301087-9vl5pqi7 authors: Teh, Benjamin W.; Worth, Leon J.; Harrison, Simon J.; Thursky, Karin A.; Slavin, Monica A. title: Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital date: 2014-12-10 journal: Support Care Cancer DOI: 10.1007/s00520-014-2550-3 sha: doc_id: 301087 cord_uid: 9vl5pqi7 file: cache/cord-301592-n5ns3m34.json key: cord-301592-n5ns3m34 authors: Ivaska, Lauri; Niemelä, Jussi; Lempainen, Johanna; Österback, Riikka; Waris, Matti; Vuorinen, Tytti; Hytönen, Jukka; Rantakokko-Jalava, Kaisu; Peltola, Ville title: Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection date: 2017-01-07 journal: J Infect DOI: 10.1016/j.jinf.2017.01.002 sha: doc_id: 301592 cord_uid: n5ns3m34 file: cache/cord-301146-no9pw4gn.json key: cord-301146-no9pw4gn authors: Lattenist, R.; Yildiz, H.; De Greef, J.; Bailly, S.; Yombi, J.C. title: COVID-19 in Adult Patients with Hematological Disease: Analysis of Clinical Characteristics and Outcomes date: 2020-07-07 journal: Indian J Hematol Blood Transfus DOI: 10.1007/s12288-020-01318-4 sha: doc_id: 301146 cord_uid: no9pw4gn file: cache/cord-300963-1n1f8mf2.json key: cord-300963-1n1f8mf2 authors: Gajendran, Mahesh; Perisetti, Abhilash; Aziz, Muhammad; Raghavapuram, Saikiran; Bansal, Pardeep; Tharian, Benjamin; Goyal, Hemant title: Inflammatory bowel disease amid the COVID-19 pandemic: impact, management strategies, and lessons learned date: 2020-10-12 journal: Ann Gastroenterol DOI: 10.20524/aog.2020.0547 sha: doc_id: 300963 cord_uid: 1n1f8mf2 file: cache/cord-301832-6czrdmzb.json key: cord-301832-6czrdmzb authors: Leber, Danielle title: PC-FACS September 1, 2020 date: 2020-09-06 journal: J Pain Symptom Manage DOI: 10.1016/j.jpainsymman.2020.09.003 sha: doc_id: 301832 cord_uid: 6czrdmzb file: cache/cord-301805-sb0ij8k7.json key: cord-301805-sb0ij8k7 authors: Fuentes, Blanca; Pastor-Yborra, Silvia; Gutiérrez-Zúñiga, Raquel; González-Pérez de Villar, Noemí; de Celis, Elena; Rodríguez-Pardo, Jorge; Gómez-de Frutos, Mari Carmen; Laso-García, Fernando; Gutiérrez-Fernández, María; Ortega-Casarrubios, MÁngeles; Soto, Alfonso; López-Fernández, María; Santamaría, María; Díez-González, Noemí; Freijo, Mar M.; Zandio, Beatriz; Delgado-Mederos, Raquel; Calleja, Ana; Portilla-Cuenca, Juan Carlos; Lisbona, Arturo; Otero-Ortega, Laura; Díez-Tejedor, Exuperio title: Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study date: 2020-11-04 journal: J Transl Med DOI: 10.1186/s12967-020-02586-4 sha: doc_id: 301805 cord_uid: sb0ij8k7 file: cache/cord-301811-ykpiorgo.json key: cord-301811-ykpiorgo authors: Tanaka, Takuma; Yamaguchi, Takayuki; Sakamoto, Yohei title: Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing date: 2020-10-28 journal: PLoS One DOI: 10.1371/journal.pone.0241170 sha: doc_id: 301811 cord_uid: ykpiorgo file: cache/cord-301579-q23nhmgs.json key: cord-301579-q23nhmgs authors: Tabaza, Luai; Virk, Hafeez ul Hassan; Janzer, Sean; George, Jon C. title: Robotic‐assisted percutaneous coronary intervention in a COVID‐19 patient date: 2020-05-20 journal: Catheter Cardiovasc Interv DOI: 10.1002/ccd.28982 sha: doc_id: 301579 cord_uid: q23nhmgs file: cache/cord-301340-lhh04pum.json key: cord-301340-lhh04pum authors: Jamieson, Frances B.; Wang, Elaine E. L.; Bain, Cindy; Good, Jennifer; Duckmanton, Lynn; Petric, Martin title: Human Torovirus: A New Nosocomial Gastrointestinal Pathogen date: 1998-11-17 journal: J Infect Dis DOI: 10.1086/314434 sha: doc_id: 301340 cord_uid: lhh04pum file: cache/cord-301590-70qmpccs.json key: cord-301590-70qmpccs authors: Campos, António; Oliveira, Nuno; Martins, Joana; Arruda, Henrique; Sousa, João title: The Paradigm Shift of Ophthalmology in the COVID-19 Era date: 2020-09-14 journal: Clin Ophthalmol DOI: 10.2147/opth.s267427 sha: doc_id: 301590 cord_uid: 70qmpccs file: cache/cord-301521-mpm43aga.json key: cord-301521-mpm43aga authors: Teixeira, Andre Luiz Schuh; Spadini, Alex Vicente; Pereira-Sanchez, Victor; Ojeahere, Margaret Isioma; Morimoto, Kana; Chang, Alice; de Filippis, Renato; Soler-Vidal, Joan title: La urgencia de implementar y ampliar la telepsiquiatría durante la crisis de COVID-19: perspectiva de los psiquiatras que inician su carrera date: 2020-06-12 journal: Rev Psiquiatr Salud Ment DOI: 10.1016/j.rpsm.2020.06.001 sha: doc_id: 301521 cord_uid: mpm43aga file: cache/cord-301402-andxwyi3.json key: cord-301402-andxwyi3 authors: Ding, Benjamin Tze Keong; Soh, Tamara; Tan, Bryan Yijia; Oh, Jacob Yoong-Leong; Mohd Fadhil, Muhammad Farhan Bin; Rasappan, Kumaran; Lee, Keng Thiam title: Operating in a Pandemic: Lessons and Strategies from an Orthopaedic Unit at the Epicenter of COVID-19 in Singapore date: 2020-05-06 journal: J Bone Joint Surg Am DOI: 10.2106/jbjs.20.00568 sha: doc_id: 301402 cord_uid: andxwyi3 file: cache/cord-301148-duttw9xn.json key: cord-301148-duttw9xn authors: Golestanieraghi, Majid; Mahmoodpoor, Ata title: Early application of prone position for management of Covid-19 patients date: 2020-05-26 journal: J Clin Anesth DOI: 10.1016/j.jclinane.2020.109917 sha: doc_id: 301148 cord_uid: duttw9xn file: cache/cord-301947-b6nwaost.json key: cord-301947-b6nwaost authors: Millán-Oñate, José; Millan, William; Mendoza, Luis Alfonso; Sánchez, Carlos Guillermo; Fernandez-Suarez, Hugo; Bonilla-Aldana, D. Katterine; Rodríguez-Morales, Alfonso J. title: Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date: 2020-04-24 journal: Ann Clin Microbiol Antimicrob DOI: 10.1186/s12941-020-00358-y sha: doc_id: 301947 cord_uid: b6nwaost file: cache/cord-302062-wqmynngg.json key: cord-302062-wqmynngg authors: Sierra-Hidalgo, Fernando; Muñoz-Rivas, Nuria; Torres Rubio, Pedro; Chao, Kateri; Villanova Martínez, Mercedes; Arranz García, Paz; Martínez-Acebes, Eva title: Large artery ischemic stroke in severe COVID-19 date: 2020-06-27 journal: J Neurol DOI: 10.1007/s00415-020-09967-1 sha: doc_id: 302062 cord_uid: wqmynngg file: cache/cord-302115-r39ser2c.json key: cord-302115-r39ser2c authors: Matricardi, Paolo Maria; Dal Negro, Roberto Walter; Nisini, Roberto title: The first, holistic immunological model of COVID‐19: implications for prevention, diagnosis, and public health measures date: 2020-05-02 journal: Pediatr Allergy Immunol DOI: 10.1111/pai.13271 sha: doc_id: 302115 cord_uid: r39ser2c file: cache/cord-301992-oin1m0uq.json key: cord-301992-oin1m0uq authors: Ferreira, Cristine Homsi Jorge; Driusso, Patricia; Haddad, Jorge Milhem; Pereira, Simone Botelho; Fernandes, Ana Carolina Nociti Lopes; Porto, Debora; Reis, Bianca Manzan; Mascarenhas, Lilian Rose; Brito, Luiz Gustavo Oliveira; Ferreira, Elizabeth Alves Gonçalves title: A guide to physiotherapy in urogynecology for patient care during the COVID-19 pandemic date: 2020-09-28 journal: Int Urogynecol J DOI: 10.1007/s00192-020-04542-8 sha: doc_id: 301992 cord_uid: oin1m0uq file: cache/cord-301779-y07xjnpe.json key: cord-301779-y07xjnpe authors: Fox, Sharon E; Akmatbekov, Aibek; Harbert, Jack L; Li, Guang; Quincy Brown, J; Vander Heide, Richard S title: Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans date: 2020-05-27 journal: Lancet Respir Med DOI: 10.1016/s2213-2600(20)30243-5 sha: doc_id: 301779 cord_uid: y07xjnpe file: cache/cord-301800-ssdzd43t.json key: cord-301800-ssdzd43t authors: Atal, Shubham; Fatima, Zeenat; Balakrishnan, Sadasivam title: Approval of Itolizumab for COVID-19: A Premature Decision or Need of The Hour? date: 2020-10-13 journal: BioDrugs DOI: 10.1007/s40259-020-00448-5 sha: doc_id: 301800 cord_uid: ssdzd43t file: cache/cord-302244-uwicyuhk.json key: cord-302244-uwicyuhk authors: Hoilat, Gilles J; Durer, Ceren; Durer, Seren; Gupta, Pratishtha title: Percutaneous Mechanical Pulmonary Thrombectomy in a Patient With Pulmonary Embolism as a First Presentation of COVID-19 date: 2020-08-01 journal: Cureus DOI: 10.7759/cureus.9506 sha: doc_id: 302244 cord_uid: uwicyuhk file: cache/cord-302389-h7jm1etb.json key: cord-302389-h7jm1etb authors: Moazenzadeh, Mansoor; Jafari, Fatemeh; Farrokhnia, Mehrdad; Aliramezany, Maryam title: First reported case of unrepaired tetralogy of Fallot complicated with coronavirus disease-19 (COVID-19) date: 2020-06-11 journal: Cardiology in the young DOI: 10.1017/s1047951120001821 sha: doc_id: 302389 cord_uid: h7jm1etb file: cache/cord-302316-raf5rlkq.json key: cord-302316-raf5rlkq authors: Brüssow, Harald title: COVID‐19: From pathogenesis models to the first drug trials date: 2020-06-23 journal: Microb Biotechnol DOI: 10.1111/1751-7915.13611 sha: doc_id: 302316 cord_uid: raf5rlkq file: cache/cord-302215-sqrbj5r4.json key: cord-302215-sqrbj5r4 authors: Vanden Eynde, Jean Jacques title: COVID-19: An Update about the Discovery Clinical Trial date: 2020-05-14 journal: Pharmaceuticals (Basel) DOI: 10.3390/ph13050098 sha: doc_id: 302215 cord_uid: sqrbj5r4 file: cache/cord-302448-2r4rtixg.json key: cord-302448-2r4rtixg authors: Kharma, Nadir; Roehrig, Stefan; Shible, Ahmed Atef; Elshafei, Moustafa Sayed; Osman, Dema; Elsaid, Ingi Mohamed; Mustafa, Salma Faisal; Aldabi, Asjad; Smain, Osamah A.M.; Lance, Marcus D. title: Anticoagulation in critically ill patients on mechanical ventilation suffering from COVID-19 disease, The ANTI-CO trial: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-07 journal: Trials DOI: 10.1186/s13063-020-04689-1 sha: doc_id: 302448 cord_uid: 2r4rtixg file: cache/cord-302177-8w3ojgd4.json key: cord-302177-8w3ojgd4 authors: Cavayas, Yiorgos Alexandros; Noël, Alexandre; Brunette, Veronique; Williamson, David; Frenette, Anne Julie; Arsenault, Christine; Bellemare, Patrick; Lagrenade-Verdant, Colin; LeGuillan, Soazig; Levesque, Emilie; Lamarche, Yoan; Giasson, Marc; Rico, Philippe; Beaulieu, Yanick; Marsolais, Pierre; Serri, Karim; Bernard, Francis; Albert, Martin title: Early experience with critically ill patients with COVID-19 in Montreal date: 2020-09-15 journal: Can J Anaesth DOI: 10.1007/s12630-020-01816-z sha: doc_id: 302177 cord_uid: 8w3ojgd4 file: cache/cord-302413-7a80jff2.json key: cord-302413-7a80jff2 authors: Brown, Timothy S.; Bedard, Nicholas A.; Rojas, Edward O.; Anthony, Christopher A.; Schwarzkopf, Ran; Lowry Barnes, C.; Stambough, Jeffrey B.; Mears, Simon C.; Edwards, Paul K.; Nandi, Sumon; Prieto, Herman; Parvizi, Javad title: The Effect of The COVID-19 Pandemic On Electively Scheduled HIP and KNEE Arthroplasty Patients in THE United States date: 2020-04-22 journal: J Arthroplasty DOI: 10.1016/j.arth.2020.04.052 sha: doc_id: 302413 cord_uid: 7a80jff2 file: cache/cord-302459-grs2x26l.json key: cord-302459-grs2x26l authors: Matin, Farhana; Jeet, Varinder; Moya, Leire; Selth, Luke A.; Chambers, Suzanne; Clements, Judith A.; Batra, Jyotsna title: A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer date: 2018-04-27 journal: Sci Rep DOI: 10.1038/s41598-018-24424-w sha: doc_id: 302459 cord_uid: grs2x26l file: cache/cord-302667-ei151qpd.json key: cord-302667-ei151qpd authors: Sekar, Raghul; Alexander, Arun; Ganesan, Sivaraman title: Challenges Faced by an Otolaryngology Resident During Covid-19 Pandemic: An Indian Perspective date: 2020-09-01 journal: Indian J Otolaryngol Head Neck Surg DOI: 10.1007/s12070-020-02096-1 sha: doc_id: 302667 cord_uid: ei151qpd file: cache/cord-302684-r4ger87o.json key: cord-302684-r4ger87o authors: Whisenant, Jennifer G.; Trama, Annalisa; Torri, Valter; De Toma, Alessandro; Viscardi, Giuseppe; Cortellini, Alessio; Micheilin, Olivier; Barlesi, Fabrice; Dingemans, Anne-Marie C.; Van Meerbeeck, Jan; Pancaldi, Vera; Soo, Ross A.; Leighl, Natasha B.; Peters, Solange; Wakelee, Heather; Garassino, Marina Chiara; Horn, Leora title: TERAVOLT: Thoracic Cancers International COVID-19 Collaboration date: 2020-05-16 journal: Cancer Cell DOI: 10.1016/j.ccell.2020.05.008 sha: doc_id: 302684 cord_uid: r4ger87o file: cache/cord-302403-kahi8cbc.json key: cord-302403-kahi8cbc authors: Miller, Robert F.; Lipman, Marc C.I. title: Pulmonary Infections date: 2009-05-15 journal: Clinical Respiratory Medicine DOI: 10.1016/b978-032304825-5.10034-0 sha: doc_id: 302403 cord_uid: kahi8cbc file: cache/cord-302788-kg8zwysg.json key: cord-302788-kg8zwysg authors: Conrad, Rachel C.; Baum, Matthew L.; Shah, Sejal B.; Levy‐Carrick, Nomi C.; Biswas, Jhilam; Schmelzer, Naomi A.; Silbersweig, David title: Duties toward Patients with Psychiatric Illness date: 2020-06-29 journal: Hastings Cent Rep DOI: 10.1002/hast.1139 sha: doc_id: 302788 cord_uid: kg8zwysg file: cache/cord-302226-0rhgmtbo.json key: cord-302226-0rhgmtbo authors: Bajpai, Vijeta; Gupta, Ekta; Mitra, Lalita Gauri; Kumar, Hemant; Maiwall, Rakhi; Soni, Kapil Dev; Gupta, Amit title: Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit date: 2019 journal: J Lab Physicians DOI: 10.4103/jlp.jlp_6_19 sha: doc_id: 302226 cord_uid: 0rhgmtbo file: cache/cord-302695-vyo3w2a4.json key: cord-302695-vyo3w2a4 authors: Albertini, Laetitia; Soletchnik, Mickael; Razurel, Anais; Cohen, Johana; Bidegain, Frédéric; Fauvelle, Francis; Safrano, Geoffroy; Piquet, Jacques; Maurer, Cyril; Goldgran-Toledano, Dany title: Observational study on off-label use of tocilizumab in patients with severe COVID-19 date: 2020-09-10 journal: Eur J Hosp Pharm DOI: 10.1136/ejhpharm-2020-002414 sha: doc_id: 302695 cord_uid: vyo3w2a4 file: cache/cord-302382-eifh95zm.json key: cord-302382-eifh95zm authors: Owji, Hajar; Negahdaripour, Manica; Hajighahramani, Nasim title: Immunotherapeutic approaches to curtail COVID-19 date: 2020-08-21 journal: Int Immunopharmacol DOI: 10.1016/j.intimp.2020.106924 sha: doc_id: 302382 cord_uid: eifh95zm file: cache/cord-302862-znnlyz3y.json key: cord-302862-znnlyz3y authors: Lim, Peter A.C. title: Transverse Myelitis date: 2019-04-17 journal: Essentials of Physical Medicine and Rehabilitation DOI: 10.1016/b978-0-323-54947-9.00162-0 sha: doc_id: 302862 cord_uid: znnlyz3y file: cache/cord-302806-1e99cygs.json key: cord-302806-1e99cygs authors: Bozkurt, Banu; Eğrilmez, Sait; Şengör, Tomris; Yıldırım, Özlem; İrkeç, Murat title: The COVID-19 Pandemic: Clinical Information for Ophthalmologists date: 2020-04-29 journal: Turk J Ophthalmol DOI: 10.4274/tjo.galenos.2020.29805 sha: doc_id: 302806 cord_uid: 1e99cygs file: cache/cord-302864-2xnq1oq7.json key: cord-302864-2xnq1oq7 authors: Quartuccio, Luca; Sonaglia, Arianna; McGonagle, Dennis; Fabris, Martina; Peghin, Maddalena; Pecori, Davide; Monte, Amato De; Bove, Tiziana; Curcio, Francesco; Bassi, Flavio; Vita, Salvatore De; Tascini, Carlo title: Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care date: 2020-05-15 journal: J Clin Virol DOI: 10.1016/j.jcv.2020.104444 sha: doc_id: 302864 cord_uid: 2xnq1oq7 file: cache/cord-302576-fv2ib5vc.json key: cord-302576-fv2ib5vc authors: Barisione, Emanuela; Grillo, Federica; Ball, Lorenzo; Bianchi, Rita; Grosso, Marco; Morbini, Patrizia; Pelosi, Paolo; Patroniti, Nicolò Antonino; De Lucia, Arduino; Orengo, Giovanni; Gratarola, Angelo; Verda, Marta; Cittadini, Giuseppe; Mastracci, Luca; Fiocca, Roberto title: Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems date: 2020-09-28 journal: Virchows Arch DOI: 10.1007/s00428-020-02934-1 sha: doc_id: 302576 cord_uid: fv2ib5vc file: cache/cord-302756-343y63e5.json key: cord-302756-343y63e5 authors: Thachil, J; Agarwal, S. title: Understanding the COVID‐19 coagulopathy spectrum date: 2020-05-21 journal: Anaesthesia DOI: 10.1111/anae.15141 sha: doc_id: 302756 cord_uid: 343y63e5 file: cache/cord-303145-rc5luali.json key: cord-303145-rc5luali authors: Banach, Maciej; Penson, Peter E.; Fras, Zlatko; Vrablik, Michal; Pella, Daniel; Reiner, Željko; Nabavi, Seyed Mohammad; Sahebkar, Amirhossein; Kayikcioglu, Meral; Daccord, Magdalena title: Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic date: 2020-05-07 journal: Pharmacol Res DOI: 10.1016/j.phrs.2020.104891 sha: doc_id: 303145 cord_uid: rc5luali file: cache/cord-303600-96vtj89w.json key: cord-303600-96vtj89w authors: Kapoor, Deeksha; Perwaiz, Azhar; Singh, Amanjeet; Chaudhary, Adarsh title: Elective Gastrointestinal Surgery in COVID Times date: 2020-10-22 journal: Indian J Surg DOI: 10.1007/s12262-020-02642-9 sha: doc_id: 303600 cord_uid: 96vtj89w file: cache/cord-302821-b9ikg0xy.json key: cord-302821-b9ikg0xy authors: Gawałko, Monika; Kapłon-Cieślicka, Agnieszka; Hohl, Mathias; Dobrev, Dobromir; Linz, Dominik title: COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications date: 2020-09-01 journal: Int J Cardiol Heart Vasc DOI: 10.1016/j.ijcha.2020.100631 sha: doc_id: 302821 cord_uid: b9ikg0xy file: cache/cord-302997-39o08tt1.json key: cord-302997-39o08tt1 authors: Ceruti, S.; Roncador, M.; Gie, O.; Bona, G.; Iattoni, M.; Biggiogero, M.; Maida, P. A.; COVID-19 Clinical Management Team,; Garzoni, C.; Mauri, R. title: Reduced mortality and shorten ICU stay in SARS-COV-2 pneumonia: a low PEEP strategy date: 2020-05-08 journal: nan DOI: 10.1101/2020.05.03.20089318 sha: doc_id: 302997 cord_uid: 39o08tt1 file: cache/cord-303017-4zx94rm6.json key: cord-303017-4zx94rm6 authors: Barbieri, Antonio; Robinson, Nirmal; Palma, Giuseppe; Maurea, Nicola; Desiderio, Vincenzo; Botti, Gerardo title: Can Beta-2-Adrenergic Pathway Be a New Target to Combat SARS-CoV-2 Hyperinflammatory Syndrome?—Lessons Learned From Cancer date: 2020-09-30 journal: Front Immunol DOI: 10.3389/fimmu.2020.588724 sha: doc_id: 303017 cord_uid: 4zx94rm6 file: cache/cord-303192-il3s8lgp.json key: cord-303192-il3s8lgp authors: Tam, Lai‐Shan; Tanaka, Yoshiya; Handa, Rohini; Chang, Chi‐Chen; Cheng, Yew Kuang; Isalm, Nazrul; Li, Mengtao; Lorenzo, Jose Paulo; Song, Yeong‐Wook; Yamamoto, Kazuhiko; Zeng, Xiaofeng; Haq, Syed Atiqul title: Care for patients with rheumatic diseases during COVID‐19 pandemic: A position statement from APLAR date: 2020-05-27 journal: Int J Rheum Dis DOI: 10.1111/1756-185x.13863 sha: doc_id: 303192 cord_uid: il3s8lgp file: cache/cord-303244-5tfrmsm7.json key: cord-303244-5tfrmsm7 authors: Kugasia, Irfanali R.; Ijaz, Mohsin; Khan, Ahsan; Jasti, Yashwanth title: Amiodarone Toxicity Presenting with Acute Onset of Systemic Inflammatory Response Syndrome and Multiorgan Failure Mimicking Sepsis date: 2020-10-23 journal: Am J Case Rep DOI: 10.12659/ajcr.926929 sha: doc_id: 303244 cord_uid: 5tfrmsm7 file: cache/cord-303065-dyg2baog.json key: cord-303065-dyg2baog authors: Williams, Michael title: Patient-Centered Surgical Care Meets the Social Determinants of Health date: 2020-09-25 journal: World J Surg DOI: 10.1007/s00268-020-05785-8 sha: doc_id: 303065 cord_uid: dyg2baog file: cache/cord-303460-abutfxtf.json key: cord-303460-abutfxtf authors: Searle, Tamara; Ali, Faisal R.; Al‐Niaimi, Firas title: Screen rhytides: the cosmetic legacy of COVID‐19 date: 2020-08-21 journal: Dermatol Ther DOI: 10.1111/dth.14211 sha: doc_id: 303460 cord_uid: abutfxtf file: cache/cord-303054-s1clwunc.json key: cord-303054-s1clwunc authors: Velly, Lionel; Gayat, Etienne; Jong, Audrey De; Quintard, Hervé; Weiss, Emmanuel; Cuvillon, Philippe; Audibert, Gerard; Amour, Julien; Beaussier, Marc; Biais, Matthieu; Bloc, Sébastien; Bonnet, Marie Pierre; Bouzat, Pierre; Brezac, Gilles; Dahyot-Fizelier, Claire; Dahmani, Souhayl; de Queiroz, Mathilde; Maria, Sophie Di; Ecoffey, Claude; Futier, Emmanuel; Geeraerts, Thomas; Jaber, Haithem; Heyer, Laurent; Hoteit, Rim; Joannes-Boyau, Olivier; Kern, Delphine; Langeron, Olivier; Lasocki, Sigismond; Launey, Yoan; Saché, Frederic le; Lukaszewicz, Anne Claire; Maurice-Szamburski, Axel; Mayeur, Nicolas; Michel, Fabrice; Minville, Vincent; Mirek, Sébastien; Montravers, Philippe; Morau, Estelle; Muller, Laurent; Muret, Jane; Nouette-Gaulain, Karine; Orban, Jean Christophe; Orliaguet, Gilles; Perrigault, Pierre François; Plantet, Florence; Pottecher, Julien; Quesnel, Christophe; Reubrecht, Vanessa; Rozec, Bertrand; Tavernier, Benoit; Veber, Benoit; Veyckmans, Francis; Charbonneau, Hélène; Constant, Isabelle; Frasca, Denis; Fischer, Marc-Olivier; Huraux, Catherine; Blet, Alice; Garnier, Marc title: Guidelines: Anaesthesia in the context of COVID-19 pandemic date: 2020-06-05 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.05.012 sha: doc_id: 303054 cord_uid: s1clwunc file: cache/cord-303363-uu9hb1c9.json key: cord-303363-uu9hb1c9 authors: Karimi, Mehran; De Sanctis, Vincenzo title: Implications of SARSr-CoV 2 infection in thalassemias: Do patients fall into the “high clinical risk” category? date: 2020-05-11 journal: Acta Biomed DOI: 10.23750/abm.v91i2.9592 sha: doc_id: 303363 cord_uid: uu9hb1c9 file: cache/cord-302800-852w35od.json key: cord-302800-852w35od authors: Liu, Xuebing; Lin, Hong; Jiang, Haifeng; Li, Ruihua; Zhong, Na; Su, Hang; Li, Yi; Zhao, Min title: Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China date: 2020-04-19 journal: Gen Psychiatr DOI: 10.1136/gpsych-2020-100222 sha: doc_id: 302800 cord_uid: 852w35od file: cache/cord-303661-etb19d6y.json key: cord-303661-etb19d6y authors: Shin, Hyoung-Shik title: Empirical Treatment and Prevention of COVID-19 date: 2020-06-22 journal: Infect Chemother DOI: 10.3947/ic.2020.52.2.142 sha: doc_id: 303661 cord_uid: etb19d6y file: cache/cord-303880-zv4nbz9p.json key: cord-303880-zv4nbz9p authors: Tsikala Vafea, Maria; Atalla, Eleftheria; Georgakas, Joanna; Shehadeh, Fadi; Mylona, Evangelia K.; Kalligeros, Markos; Mylonakis, Eleftherios title: Emerging Technologies for Use in the Study, Diagnosis, and Treatment of Patients with COVID-19 date: 2020-06-24 journal: Cell Mol Bioeng DOI: 10.1007/s12195-020-00629-w sha: doc_id: 303880 cord_uid: zv4nbz9p file: cache/cord-303349-0kn7apl3.json key: cord-303349-0kn7apl3 authors: Lippi, Giuseppe; Mattiuzzi, Camilla title: Hemoglobin value may be decreased in patients with severe coronavirus disease 2019 date: 2020-04-02 journal: Hematol Transfus Cell Ther DOI: 10.1016/j.htct.2020.03.001 sha: doc_id: 303349 cord_uid: 0kn7apl3 file: cache/cord-304010-n4gxxl5i.json key: cord-304010-n4gxxl5i authors: Sung, Ho Kyung; Kim, Jin Yong; Heo, Jeonghun; Seo, Haesook; Jang, Young soo; Kim, Hyewon; Koh, Bo Ram; Jo, Neungsun; Oh, Hong Sang; Baek, Young Mi; Park, Kyung-Hwa; Shon, Jeung A; Kim, Min-Chul; Kim, Joon Ho; Chang, Hyun-Ha; Park, Yukyung; Kang, Yu Min; Lee, Dong Hyun; Oh, Dong Hyun; Park, Hyun Jung; Song, Kyoung-Ho; Lee, Eun Kyoung; Jeong, Hyeongseok; Lee, Ji Yeon; Ko, Ja-Young; Choi, Jihee; Ryu, Eun Hwa; Chung, Ki-hyun; Oh, Myoung-don title: Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January–May 2020 date: 2020-07-28 journal: J Korean Med Sci DOI: 10.3346/jkms.2020.35.e280 sha: doc_id: 304010 cord_uid: n4gxxl5i file: cache/cord-303483-wendrxee.json key: cord-303483-wendrxee authors: Rubin, Geoffrey D.; Ryerson, Christopher J.; Haramati, Linda B.; Sverzellati, Nicola; Kanne, Jeffrey P.; Raoof, Suhail; Schluger, Neil W.; Volpi, Annalisa; Yim, Jae-Joon; Martin, Ian B. K.; Anderson, Deverick J.; Kong, Christina; Altes, Talissa; Bush, Andrew; Desai, Sujal R.; Goldin, Jonathan; Goo, Jin Mo; Humbert, Marc; Inoue, Yoshikazu; Kauczor, Hans-Ulrich; Luo, Fengming; Mazzone, Peter J.; Prokop, Mathias; Remy-Jardin, Martine; Richeldi, Luca; Schaefer-Prokop, Cornelia M.; Tomiyama, Noriyuki; Wells, Athol U.; Leung, Ann N. title: The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society date: 2020-04-07 journal: Radiology DOI: 10.1148/radiol.2020201365 sha: doc_id: 303483 cord_uid: wendrxee file: cache/cord-303517-8971aq02.json key: cord-303517-8971aq02 authors: Cajamarca-Baron, Jairo; Guavita-Navarro, Diana; Buitrago-Bohorquez, Jhon; Gallego-Cardona, Laura; Navas, Angela; Cubides, Hector; Arredondo, Ana María; Escobar, Alejandro; Rojas-Villarraga, Adriana title: SARS-CoV-2 (COVID-19) in Patients with some Degree of Immunosuppression date: 2020-10-16 journal: nan DOI: 10.1016/j.reumae.2020.08.001 sha: doc_id: 303517 cord_uid: 8971aq02 file: cache/cord-303718-7bpap31f.json key: cord-303718-7bpap31f authors: Binder, Adam F.; Handley, Nathan R.; Wilde, Lindsay; Palmisiano, Neil; Lopez, Ana Maria title: Treating Hematologic Malignancies During a Pandemic: Utilizing Telehealth and Digital Technology to Optimize Care date: 2020-06-26 journal: Front Oncol DOI: 10.3389/fonc.2020.01183 sha: doc_id: 303718 cord_uid: 7bpap31f file: cache/cord-303816-c4z9ys3q.json key: cord-303816-c4z9ys3q authors: Xu, YuShuang; Xiong, LiNa; Li, YaNan; Jiang, Xin; Xiong, ZhiFan title: Diagnostic methods and drug therapies in patients with ischemic colitis date: 2020-09-16 journal: Int J Colorectal Dis DOI: 10.1007/s00384-020-03739-z sha: doc_id: 303816 cord_uid: c4z9ys3q file: cache/cord-304090-l5rocsk5.json key: cord-304090-l5rocsk5 authors: Akbar, Aelia; Iqbal, Aqsa; Gaziano, Dominic; Gasior, Filip; Zaidi, Ayesha J; Iqbal, Anum; Silva, Abigail title: A Cross-Sectional Survey on Telemedicine Use for Doctor-Patient Communication date: 2020-09-12 journal: Cureus DOI: 10.7759/cureus.10402 sha: doc_id: 304090 cord_uid: l5rocsk5 file: cache/cord-303787-dx1n8jap.json key: cord-303787-dx1n8jap authors: Vonck, Kristl; Garrez, Ieme; De Herdt, Veerle; Hemelsoet, Dimitri; Laureys, Guy; Raedt, Robrecht; Boon, Paul title: Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 date: 2020-05-16 journal: Eur J Neurol DOI: 10.1111/ene.14329 sha: doc_id: 303787 cord_uid: dx1n8jap file: cache/cord-304271-vyayyk50.json key: cord-304271-vyayyk50 authors: Qin, Yuan-Yuan; Zhou, Yi-Hong; Lu, Yan-Qiu; Sun, Feng; Yang, Sen; Harypursat, Vijay; Chen, Yao-Kai title: Effectiveness of glucocorticoid therapy in patients with severe coronavirus disease 2019: protocol of a randomized controlled trial date: 2020-03-05 journal: Chin Med J (Engl) DOI: 10.1097/cm9.0000000000000791 sha: doc_id: 304271 cord_uid: vyayyk50 file: cache/cord-303819-w1785lap.json key: cord-303819-w1785lap authors: Cortegiani, Andrea; Ippolito, Mariachiara; Ingoglia, Giulia; Iozzo, Pasquale; Giarratano, Antonino; Einav, Sharon title: Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19 date: 2020-07-11 journal: J Crit Care DOI: 10.1016/j.jcrc.2020.06.019 sha: doc_id: 303819 cord_uid: w1785lap file: cache/cord-304573-3nhglbw4.json key: cord-304573-3nhglbw4 authors: Bola, Sumrit; Jaikaransingh, Dominic; Winter, Stuart C title: COVID-19 and the return to head and neck outpatient activity in the United Kingdom: what is the new normal? date: 2020-11-06 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06458-x sha: doc_id: 304573 cord_uid: 3nhglbw4 file: cache/cord-304602-jpxjiaru.json key: cord-304602-jpxjiaru authors: Anneser, Johanna title: Dying patients with COVID-19: What should Hospital Palliative Care Teams (HPCTs) be prepared for? date: 2020-06-23 journal: Palliative & supportive care DOI: 10.1017/s1478951520000450 sha: doc_id: 304602 cord_uid: jpxjiaru file: cache/cord-303703-ekhwb5xb.json key: cord-303703-ekhwb5xb authors: Mash, Bob title: Primary care management of the coronavirus (COVID-19) date: 2020-03-31 journal: S Afr Fam Pract (2004) DOI: 10.4102/safp.v62i1.5115 sha: doc_id: 303703 cord_uid: ekhwb5xb file: cache/cord-303860-jpy373ph.json key: cord-303860-jpy373ph authors: Huang, Zhifeng; Zhuang, Donglin; Xiong, Bing; Deng, David Xingfei; Li, Hanhua; Lai, Wen title: Occupational Exposure to SARS-CoV-2 in Burns Treatment During the COVID-19 Epidemic: Specific Diagnosis and Treatment Protocol date: 2020-04-23 journal: Biomed Pharmacother DOI: 10.1016/j.biopha.2020.110176 sha: doc_id: 303860 cord_uid: jpy373ph file: cache/cord-304280-2a84u4tm.json key: cord-304280-2a84u4tm authors: Masic, Izet; Naser, Nabil; Zildzic, Muharem title: Public Health Aspects of COVID-19 Infection with Focus on Cardiovascular Diseases date: 2020-03-17 journal: Mater Sociomed DOI: 10.5455/msm.2020.32.71-76 sha: doc_id: 304280 cord_uid: 2a84u4tm file: cache/cord-304601-e6qlx1r6.json key: cord-304601-e6qlx1r6 authors: Garcez, Flavia Barreto; Aliberti, Marlon Juliano Romero; Poco, Paula Cristina Eiras; Hiratsuka, Marcel; de Fatima Takahashi, Silvia; Coelho, Venceslau Antonio; Salotto, Danute Bareisys; Moreira, Marlos Luiz Villela; Jacob Filho, Wilson; Avelino Silva, Thiago J. title: Delirium and adverse outcomes in hospitalized patients with COVID‐19. date: 2020-08-24 journal: J Am Geriatr Soc DOI: 10.1111/jgs.16803 sha: doc_id: 304601 cord_uid: e6qlx1r6 file: cache/cord-303791-yw80ndg6.json key: cord-303791-yw80ndg6 authors: Ashique, Karalikkattil T.; Kaliyadan, Feroze title: Teledermatology in the Wake of COVID -19 Scenario: An Indian Perspective date: 2020-05-10 journal: Indian Dermatol Online J DOI: 10.4103/idoj.idoj_260_20 sha: doc_id: 303791 cord_uid: yw80ndg6 file: cache/cord-304248-sxbyxnxn.json key: cord-304248-sxbyxnxn authors: Aiolfi, Alberto; Biraghi, Tullio; Montisci, Andrea; Bonitta, Gianluca; Micheletto, Giancarlo; Donatelli, Francesco; Cirri, Silvia; Bona, Davide title: MANAGEMENT OF PERSISTENT PNEUMOTHORAX WITH THORACOSCOPY AND BLEBS RESECTION IN COVID-19 PATIENTS date: 2020-04-27 journal: Ann Thorac Surg DOI: 10.1016/j.athoracsur.2020.04.011 sha: doc_id: 304248 cord_uid: sxbyxnxn file: cache/cord-304593-cugypxp0.json key: cord-304593-cugypxp0 authors: Dhillon, M. S.; Kumar, Deepak; Saini, Uttam Chand; Bhayana, Himanshu; Gopinathan, Nirmal Raj; Aggarwal, Sameer title: Changing Pattern of Orthopaedic Trauma Admissions During COVID-19 Pandemic: Experience at a Tertiary Trauma Centre in India date: 2020-08-28 journal: Indian J Orthop DOI: 10.1007/s43465-020-00241-0 sha: doc_id: 304593 cord_uid: cugypxp0 file: cache/cord-304949-mf3utolt.json key: cord-304949-mf3utolt authors: Porzio, Giampiero; Cortellini, Alessio; Bruera, Eduardo; Verna, Lucilla; Ravoni, Giulio; Peris, Flaminia; Spinelli, Giuseppe title: Home Care for Cancer Patients During COVID-19 Pandemic: The Double Triage Protocol date: 2020-03-31 journal: J Pain Symptom Manage DOI: 10.1016/j.jpainsymman.2020.03.021 sha: doc_id: 304949 cord_uid: mf3utolt file: cache/cord-304474-hfv43e9m.json key: cord-304474-hfv43e9m authors: Marchese, Valentina; Crosato, Verena; Gulletta, Maurizio; Castelnuovo, Filippo; Cristini, Graziella; Matteelli, Alberto; Castelli, Francesco title: Strongyloides infection manifested during immunosuppressive therapy for SARS-CoV-2 pneumonia date: 2020-09-10 journal: Infection DOI: 10.1007/s15010-020-01522-4 sha: doc_id: 304474 cord_uid: hfv43e9m file: cache/cord-304255-7xs9cit7.json key: cord-304255-7xs9cit7 authors: Parrish, Richard K.; Higginbotham, Eve J. title: What Does Telemedicine Mean for the Care of Patients With Glaucoma in the Age of COVID-19? date: 2020-08-13 journal: Am J Ophthalmol DOI: 10.1016/j.ajo.2020.07.038 sha: doc_id: 304255 cord_uid: 7xs9cit7 file: cache/cord-304457-8g36h1bz.json key: cord-304457-8g36h1bz authors: Idelsis, E.-M.; Jesus, P.-E.; Yaquelin, D.-R.; Dania, V.-B.; Monica, B.-R.; Lisandra, B.-R.; Jesus, C.-R.; Lisbeth, C. C.; Ernesto, P.-C.; Saily, T.-P.; Claudia, M.-S.; Ivan, C.-L.; Julio Raul, F.-M.; Hamlet, C.-R.; Marisol, D.-G.; Adriana, S.-M.; Maura, G.-S.; Sara Maria, M.-M.; Marel, A.-V.; Francisco, H.-B.; Hugo, N.-C.; Dianela, B.-G.; Abrahan, B.-C.; Mary Tania, V.-C.; Gerardo, G.-N.; Verena, M.-G.; Iraldo, B.-R. title: Effect and safety of combination of interferon alpha-2b and gamma or interferon alpha-2b for negativization of SARS-CoV-2 viral RNA. Preliminary results of a randomized controlled clinical trial. date: 2020-08-01 journal: nan DOI: 10.1101/2020.07.29.20164251 sha: doc_id: 304457 cord_uid: 8g36h1bz file: cache/cord-304418-k9owyolj.json key: cord-304418-k9owyolj authors: Le Maréchal, M.; Morand, P.; Epaulard, O.; Némoz, B. title: COVID-19 in clinical practice: a narrative synthesis date: 2020-09-29 journal: Med Mal Infect DOI: 10.1016/j.medmal.2020.09.012 sha: doc_id: 304418 cord_uid: k9owyolj file: cache/cord-305134-s7h6bpof.json key: cord-305134-s7h6bpof authors: Mackman, Nigel; Antoniak, Silvio; Wolberg, Alisa S.; Kasthuri, Raj; Key, Nigel S. title: Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses date: 2020-07-13 journal: Arterioscler Thromb Vasc Biol DOI: 10.1161/atvbaha.120.314514 sha: doc_id: 305134 cord_uid: s7h6bpof file: cache/cord-304798-j2tyjo1j.json key: cord-304798-j2tyjo1j authors: Rapkiewicz, Amy V.; Mai, Xingchen; Carsons, Steven E.; Pittaluga, Stefania; Kleiner, David E.; Berger, Jeffrey S.; Thomas, Sarun; Adler, Nicole M.; Charytan, David M.; Gasmi, Billel; Hochman, Judith S.; Reynolds, Harmony R. title: Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series date: 2020-06-25 journal: EClinicalMedicine DOI: 10.1016/j.eclinm.2020.100434 sha: doc_id: 304798 cord_uid: j2tyjo1j file: cache/cord-305076-v56y5nyt.json key: cord-305076-v56y5nyt authors: Singh, Parmvir; Schwartz, Robert A. title: Disseminated Intravascular Coagulation: A Devastating Systemic Disorder of Special Concern with COVID‐19 date: 2020-07-23 journal: Dermatol Ther DOI: 10.1111/dth.14053 sha: doc_id: 305076 cord_uid: v56y5nyt file: cache/cord-304321-y177sqee.json key: cord-304321-y177sqee authors: Cho, Ryan H. W.; Yeung, Zenon W. C.; Ho, Osan Y. M.; Lo, Jacky F. W.; Siu, Alice K. Y.; Kwan, Wendy M. Y.; To, Zion W. H.; Chan, Anthony W. H.; Chan, Becky Y. T.; Fung, Kitty S. C.; Abdullah, Victor; Tong, Michael C. F.; Ku, Peter K. M. title: Pearls of experience for safe and efficient hospital practices in otorhinolaryngology—head and neck surgery in Hong Kong during the 2019 novel coronavirus disease (COVID-19) pandemic date: 2020-05-15 journal: J Otolaryngol Head Neck Surg DOI: 10.1186/s40463-020-00427-4 sha: doc_id: 304321 cord_uid: y177sqee file: cache/cord-305397-4dx3q6o6.json key: cord-305397-4dx3q6o6 authors: Ashraf, Muddasir; Sajed, Sulaiman title: Seizures Related to Coronavirus Disease (COVID-19): Case Series and Literature Review date: 2020-07-24 journal: Cureus DOI: 10.7759/cureus.9378 sha: doc_id: 305397 cord_uid: 4dx3q6o6 file: cache/cord-305139-851v2qr3.json key: cord-305139-851v2qr3 authors: Peys, Elise; Stevens, Dieter; Weygaerde, Yannick Vande; Malfait, Thomas; Hermie, Laurens; Rogiers, Philippe; Depuydt, Pieter; Van Braeckel, Eva title: Haemoptysis as the first presentation of COVID-19: a case report date: 2020-10-22 journal: BMC Pulm Med DOI: 10.1186/s12890-020-01312-6 sha: doc_id: 305139 cord_uid: 851v2qr3 file: cache/cord-304399-7t2mu13s.json key: cord-304399-7t2mu13s authors: Wynne, Keona Jeane; Petrova, Mila; Coghlan, Rachel title: Dying individuals and suffering populations: applying a population-level bioethics lens to palliative care in humanitarian contexts: before, during and after the COVID-19 pandemic date: 2020-06-19 journal: J Med Ethics DOI: 10.1136/medethics-2019-105943 sha: doc_id: 304399 cord_uid: 7t2mu13s file: cache/cord-305520-7gxmdo56.json key: cord-305520-7gxmdo56 authors: Lim, Wei Sing; Grimaldi, Gabriela; Nicholson, Luke; Basheer, Khadijah; Rajendram, Ranjan title: Widefield imaging with Clarus fundus camera vs slit lamp fundus examination in assessing patients referred from the National Health Service diabetic retinopathy screening programme date: 2020-10-20 journal: Eye (Lond) DOI: 10.1038/s41433-020-01218-x sha: doc_id: 305520 cord_uid: 7gxmdo56 file: cache/cord-304791-wv4qu9xm.json key: cord-304791-wv4qu9xm authors: Carfora, Vincenzo; Spiniello, Giorgio; Ricciolino, Riccardo; Di Mauro, Marco; Migliaccio, Marco Giuseppe; Mottola, Filiberto Fausto; Verde, Nicoletta; Coppola, Nicola title: Anticoagulant treatment in COVID-19: a narrative review date: 2020-08-18 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02242-0 sha: doc_id: 304791 cord_uid: wv4qu9xm file: cache/cord-305283-1bg1ykui.json key: cord-305283-1bg1ykui authors: ElSeirafi, Mohamed MA.; Hasan, Hasan MSN.; Sridharan, Kannan; Zamoori, Alaa; Alkhawaja, Sana; Pasha, Sheikh Abdulla A. title: Efficacy and safety of tocilizumab in critically ill adults with COVID-19 infection in Bahrain: A report of 5 cases date: 2020-06-23 journal: Respir Med Case Rep DOI: 10.1016/j.rmcr.2020.101139 sha: doc_id: 305283 cord_uid: 1bg1ykui file: cache/cord-306092-5bi2q3jj.json key: cord-306092-5bi2q3jj authors: Choi, Hee Joung; Kim, Yeo Hyang title: Relationship between the Clinical Characteristics and Intervention Scores of Infants with Apparent Life-threatening Events date: 2015-05-13 journal: J Korean Med Sci DOI: 10.3346/jkms.2015.30.6.763 sha: doc_id: 306092 cord_uid: 5bi2q3jj file: cache/cord-304972-aktfbriw.json key: cord-304972-aktfbriw authors: Cots, Josep M.; Alós, Juan-Ignacio; Bárcena, Mario; Boleda, Xavier; Cañada, José L.; Gómez, Niceto; Mendoza, Ana; Vilaseca, Isabel; Llor, Carles title: Recommendations for Management of Acute Pharyngitis in Adults date: 2015-06-30 journal: Acta Otorrinolaringologica (English Edition) DOI: 10.1016/j.otoeng.2015.05.003 sha: doc_id: 304972 cord_uid: aktfbriw file: cache/cord-305205-ilxxkm0f.json key: cord-305205-ilxxkm0f authors: Cochennec, Frédéric; Kobeiter, Hicham; Gohel, Manj S.; Majewski, Marek; Marzelle, Jean; Desgranges, Pascal; Allaire, Eric; Becquemin, Jean Pierre title: Impact of intraoperative adverse events during branched and fenestrated aortic stent grafting on postoperative outcome date: 2014-09-30 journal: Journal of Vascular Surgery DOI: 10.1016/j.jvs.2014.02.065 sha: doc_id: 305205 cord_uid: ilxxkm0f file: cache/cord-305498-8tmtvw1r.json key: cord-305498-8tmtvw1r authors: Singh Saraj, K.; Mishra Vishal, A.; Jha Vikas, C. title: Modification of Neurosurgical Practice during Corona Pandemic: Our Experience at AIIMS Patna And Long Term Guidelines date: 2020-09-10 journal: Interdiscip Neurosurg DOI: 10.1016/j.inat.2020.100895 sha: doc_id: 305498 cord_uid: 8tmtvw1r file: cache/cord-305650-su6furzi.json key: cord-305650-su6furzi authors: Sud, Karan; Vogel, Birgit; Bohra, Chandrashekar; Garg, Vaani; Talebi, Soheila; Lerakis, Stamatios; Narula, Jagat; Argulian, Edgar title: Echocardiographic Findings in COVID-19 Patients with Significant Myocardial Injury date: 2020-06-05 journal: J Am Soc Echocardiogr DOI: 10.1016/j.echo.2020.05.030 sha: doc_id: 305650 cord_uid: su6furzi file: cache/cord-305838-i0ck2oo0.json key: cord-305838-i0ck2oo0 authors: Kouri, Andrew; Gupta, Samir; Yadollahi, Azadeh; Ryan, Clodagh M.; Gershon, Andrea S.; To, Teresa; Tarlo, Susan M.; Goldstein, Roger S.; Chapman, Kenneth R.; Chow, Chung-Wai title: CHEST Reviews: Addressing reduced laboratory-based pulmonary function testing during a pandemic date: 2020-07-08 journal: Chest DOI: 10.1016/j.chest.2020.06.065 sha: doc_id: 305838 cord_uid: i0ck2oo0 file: cache/cord-306062-g9hk1iq5.json key: cord-306062-g9hk1iq5 authors: Silverman, Dustin A.; Lin, Chen; Tamaki, Akina; Puram, Sidharth V.; Carrau, Ricardo L.; Seim, Nolan B.; Eskander, Antoine; Rocco, James W.; Old, Matthew O.; Kang, Stephen Y. title: Respiratory and pulmonary complications in head and neck cancer patients: Evidence‐based review for the COVID‐19 era date: 2020-04-30 journal: Head Neck DOI: 10.1002/hed.26217 sha: doc_id: 306062 cord_uid: g9hk1iq5 file: cache/cord-305304-d3x734nu.json key: cord-305304-d3x734nu authors: Birnbaum, Yochai; Levine, Glenn N.; French, John; Kaski, Juan Carlos; Atar, Dan; Alam, Mahboob; Hasdai, David; Jneid, Hani; Uretsky, Barry F. title: Inferior ST-Elevation Myocardial Infarction Presenting When Urgent Primary Percutaneous Coronary Intervention Is Unavailable: Should We Adhere to Current Guidelines? date: 2020-07-15 journal: Cardiovasc Drugs Ther DOI: 10.1007/s10557-020-07039-0 sha: doc_id: 305304 cord_uid: d3x734nu file: cache/cord-306149-sd0s0jup.json key: cord-306149-sd0s0jup authors: Ratanarat, Ranistha; Sivakorn, Chaisith; Viarasilpa, Tanuwong; Schultz, Marcus J. title: Critical Care Management of Patients with COVID-19: Early Experience in Thailand date: 2020-05-18 journal: Am J Trop Med Hyg DOI: 10.4269/ajtmh.20-0442 sha: doc_id: 306149 cord_uid: sd0s0jup file: cache/cord-305422-t8azymo7.json key: cord-305422-t8azymo7 authors: Yi, Ye; Lagniton, Philip N.P.; Ye, Sen; Li, Enqin; Xu, Ren-He title: COVID-19: what has been learned and to be learned about the novel coronavirus disease date: 2020-03-15 journal: Int J Biol Sci DOI: 10.7150/ijbs.45134 sha: doc_id: 305422 cord_uid: t8azymo7 file: cache/cord-304479-uxp1kg86.json key: cord-304479-uxp1kg86 authors: Goodarzi, Pedram; Mahdavi, Farzad; Mirzaei, Rasoul; Hasanvand, Hamze; Sholeh, Mohammad; Zamani, Farhad; Sohrabi, Masodreza; Tabibzadeh, Alireza; Jeda, Ali Salimi; Niya, Mohammad Hadi Karbalaie; Keyvani, Hossein; Karampoor, Sajad title: Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments date: 2020-08-08 journal: Int Immunopharmacol DOI: 10.1016/j.intimp.2020.106885 sha: doc_id: 304479 cord_uid: uxp1kg86 file: cache/cord-305405-me4gebvm.json key: cord-305405-me4gebvm authors: Conway, J.; Gould, A.; Westley, R.; Raju, S.; Oklopcic, A.; Broadbent, A.; Abdelhafiz, AH.; Sinclair, AJ. title: Characteristics of patients with diabetes hospitalised for COVID-19 infection-a brief case series report date: 2020-09-21 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108460 sha: doc_id: 305405 cord_uid: me4gebvm file: cache/cord-305479-o47mv4uw.json key: cord-305479-o47mv4uw authors: Feng, Xiaobo; Li, Peiyun; Ma, Liang; Liang, Hang; Lei, Jie; Li, Wenqiang; Wang, Kun; Song, Yu; Li, Shuai; Yang, Wei; Yang, Cao title: Clinical Characteristics and Short-Term Outcomes of Severe Patients With COVID-19 in Wuhan, China date: 2020-08-06 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00491 sha: doc_id: 305479 cord_uid: o47mv4uw file: cache/cord-306090-i8sriw08.json key: cord-306090-i8sriw08 authors: Tan, Zihui; Khoo, Deborah Wen Shi; Zeng, Ling Antonia; Tien, Jong-Chie Claudia; Lee, Aaron Kwang Yang; Ong, Yee Yian; Teo, Miqi Mavis; Abdullah, Hairil Rizal title: Protecting health care workers in the front line: Innovation in COVID-19 pandemic date: 2020-05-15 journal: Journal of global health DOI: 10.7189/jogh.10.010357 sha: doc_id: 306090 cord_uid: i8sriw08 file: cache/cord-305959-x061q8t7.json key: cord-305959-x061q8t7 authors: Davoudi-Monfared, Effat; Rahmani, Hamid; Khalili, Hossein; Hajiabdolbaghi, Mahboubeh; Salehi, Mohamadreza; Abbasian, Ladan; Kazemzadeh, Hossein; Yekaninejad, Mir Saeed title: A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19 date: 2020-08-20 journal: Antimicrob Agents Chemother DOI: 10.1128/aac.01061-20 sha: doc_id: 305959 cord_uid: x061q8t7 file: cache/cord-306108-ja0wyr5w.json key: cord-306108-ja0wyr5w authors: B K, Anupama; Chaudhuri, Debanik title: A Review of Acute Myocardial Injury in Coronavirus Disease 2019 date: 2020-06-03 journal: Cureus DOI: 10.7759/cureus.8426 sha: doc_id: 306108 cord_uid: ja0wyr5w file: cache/cord-306266-8qdrshz3.json key: cord-306266-8qdrshz3 authors: Scully, Crispian title: Respiratory medicine date: 2014-06-25 journal: Scully's Medical Problems in Dentistry DOI: 10.1016/b978-0-7020-5401-3.00015-1 sha: doc_id: 306266 cord_uid: 8qdrshz3 file: cache/cord-305534-936peb1n.json key: cord-305534-936peb1n authors: Johnson, Kemmian D.; Harris, Christen; Cain, John K.; Hummer, Cicily; Goyal, Hemant; Perisetti, Abhilash title: Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19 date: 2020-08-13 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00526 sha: doc_id: 305534 cord_uid: 936peb1n file: cache/cord-305582-3hmsknon.json key: cord-305582-3hmsknon authors: Li, Lei; Li, Ranran; Wu, Zhixiong; Yang, Xianghong; Zhao, Mingyan; Liu, Jiao; Chen, Dechang title: Therapeutic strategies for critically ill patients with COVID-19 date: 2020-04-20 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00661-z sha: doc_id: 305582 cord_uid: 3hmsknon file: cache/cord-306595-ru725fbr.json key: cord-306595-ru725fbr authors: Ammor, Othmane; Abdessamad, Ait Brik; Boussaadani, Badre El; Mahdi, Zainab; Najdi, Adil; Raissuni, Zainab title: Hidroxicloroquina / cloroquina y azitromicina en pacientes con COVID-19: estudio prospectivo de parámetros eléctricos date: 2020-09-11 journal: nan DOI: 10.1016/j.rccl.2020.09.002 sha: doc_id: 306595 cord_uid: ru725fbr file: cache/cord-306670-c2jm0g88.json key: cord-306670-c2jm0g88 authors: Zhang, Yan; Cui, Yanhui; Shen, Minxue; Zhang, Jianchu; Liu, Ben; Dai, Minhui; Chen, Lingli; Han, Duoduo; Fan, Yifei; Zeng, Yanjun; Li, Wen; Lin, Fengyu; Li, Sha; Chen, Xiang; Pan, Pinhua title: Association of Diabetes Mellitus with Disease Severity and Prognosis in COVID-19: A Retrospective Cohort Study date: 2020-05-22 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108227 sha: doc_id: 306670 cord_uid: c2jm0g88 file: cache/cord-306790-82nltfk3.json key: cord-306790-82nltfk3 authors: Sheikh, Abu Baker; Shekhar, Rahul; Javed, Nismat; Upadhyay, Shubhra title: Inferior Wall Myocardial Infarction in Severe COVID-19 Infection: A Case Report date: 2020-09-28 journal: Am J Case Rep DOI: 10.12659/ajcr.926101 sha: doc_id: 306790 cord_uid: 82nltfk3 file: cache/cord-305786-06dpjik8.json key: cord-305786-06dpjik8 authors: Sandora, Thomas J.; Harper, Marvin B. title: Pneumonia in Hospitalized Children date: 2005-07-09 journal: Pediatr Clin North Am DOI: 10.1016/j.pcl.2005.03.004 sha: doc_id: 305786 cord_uid: 06dpjik8 file: cache/cord-306016-2gudro8v.json key: cord-306016-2gudro8v authors: Pelt, Christopher E.; Campbell, Kevin L.; Gililland, Jeremy M.; Anderson, Lucas A.; Peters, Christopher L.; Barnes, C. Lowry; Edwards, Paul K.; Mears, Simon C.; Stambough, Jeffrey B. title: The Rapid Response to the COVID-19 Pandemic by the Arthroplasty Divisions at Two Academic Referral Centers date: 2020-04-21 journal: J Arthroplasty DOI: 10.1016/j.arth.2020.04.030 sha: doc_id: 306016 cord_uid: 2gudro8v file: cache/cord-306351-ka6asw3m.json key: cord-306351-ka6asw3m authors: Alsuliman, Tamim; Alasadi, Lugien; Alkharat, Banan; Srour, Micha; Alrstom, Ali title: A review of potential treatments to date in COVID-19 patients according to the stage of the disease date: 2020-05-30 journal: Curr Res Transl Med DOI: 10.1016/j.retram.2020.05.004 sha: doc_id: 306351 cord_uid: ka6asw3m file: cache/cord-306154-nm0g79ih.json key: cord-306154-nm0g79ih authors: JEGANATHAN, Sumithra; PRASANNAN, Lakha; BLITZ, Matthew J.; VOHRA, Nidhi; ROCHELSON, Burton; MEIROWITZ, Natalie title: Adherence and Acceptability of Telehealth Appointments for High Risk Obstetrical Patients During the COVID-19 Pandemic date: 2020-09-22 journal: Am J Obstet Gynecol MFM DOI: 10.1016/j.ajogmf.2020.100233 sha: doc_id: 306154 cord_uid: nm0g79ih file: cache/cord-307100-w33e2078.json key: cord-307100-w33e2078 authors: Douedi, Steven; Albayati, Asseel; Alfraji, Nasam; Mazahir, Usman; Costanzo, Eric title: Successful Maternal and Fetal Outcomes in COVID-19 Pregnant Women: An Institutional Approach date: 2020-07-27 journal: Am J Case Rep DOI: 10.12659/ajcr.925513 sha: doc_id: 307100 cord_uid: w33e2078 file: cache/cord-306377-s9j21zsy.json key: cord-306377-s9j21zsy authors: Yan, Li; Zhang, Hai-Tao; Goncalves, Jorge; Xiao, Yang; Wang, Maolin; Guo, Yuqi; Sun, Chuan; Tang, Xiuchuan; Jin, Liang; Zhang, Mingyang; Huang, Xiang; Xiao, Ying; Cao, Haosen; Chen, Yanyan; Ren, Tongxin; Wang, Fang; Xiao, Yaru; Huang, Sufang; Tan, Xi; Huang, Niannian; Jiao, Bo; Zhang, Yong; Luo, Ailin; Mombaerts, Laurent; Jin, Junyang; Cao, Zhiguo; Li, Shusheng; Xu, Hui; Yuan, Ye title: A machine learning-based model for survival prediction in patients with severe COVID-19 infection date: 2020-03-01 journal: nan DOI: 10.1101/2020.02.27.20028027 sha: doc_id: 306377 cord_uid: s9j21zsy file: cache/cord-306997-84pjfawk.json key: cord-306997-84pjfawk authors: Melazzini, Federica; Colaneri, Marta; Fumoso, Federica; Freddi, Giulia; Lenti, Marco Vincenzo; Pieri, Teresa Chiara; Piloni, Davide; Noris, Patrizia; Pieresca, Carla; Preti, Paola Stefania; Russo, Mariaconcetta; Corsico, Angelo; Tavazzi, Guido; Baldanti, Fausto; Triarico, Antonio; Mojoli, Francesco; Bruno, Raffaele; Di Sabatino, Antonio title: Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy date: 2020-11-08 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02550-6 sha: doc_id: 306997 cord_uid: 84pjfawk file: cache/cord-307160-1vz0gw1w.json key: cord-307160-1vz0gw1w authors: Morais-Almeida, Mário; Aguiar, Rita; Martin, Bryan; Ansotegui, Ignacio J.; Ebisawa, Motohiro; Arruda, L. Karla; Caminati, Marco; Canonica, Giorgio Walter; Carr, Tara; Chupp, Geoffrey; Corren, Jonathan; Dávila, Ignacio; Park, Hae-Sim; Hanania, Nicola A.; Rosenwasser, Lanny; Sánchez-Borges, Mario; Virchow, J. Christian; Yáñez, Anahí; Bernstein, Jonathan A.; Caraballo, Luis; Chang, Yoon-Seok; Chikhladze, Manana; Fiocchi, Alessandro; González-Diaz, Sandra N.; Tanno, Luciana Kase; Levin, Michael; Ortega-Martell, Jose António; Passalacqua, Giovanni; Peden, David B.; Rouadi, Philip W.; Sublett, James L.; Wong, Gary W.K.; Bleecker, Eugene R. title: COVID-19, asthma, and biologic therapies: What we need to know date: 2020-05-16 journal: World Allergy Organ J DOI: 10.1016/j.waojou.2020.100126 sha: doc_id: 307160 cord_uid: 1vz0gw1w file: cache/cord-306646-6c7n0xir.json key: cord-306646-6c7n0xir authors: Crimi, Claudia; Impellizzeri, Pietro; Campisi, Raffaele; Spicuzza, Lucia; Vancheri, Carlo; Crimi, Nunzio title: Resumption of Respiratory Outpatient Services in the COVID-19 era: experience from Southern Italy date: 2020-07-02 journal: Am J Infect Control DOI: 10.1016/j.ajic.2020.06.210 sha: doc_id: 306646 cord_uid: 6c7n0xir file: cache/cord-307258-66lwpblq.json key: cord-307258-66lwpblq authors: Li, Weixia; Huang, Jiapeng; Guo, Xiangyang; Zhao, Jing; Mandell, M. Susan title: Anesthesia Management and Perioperative Infection Control in Patients With the Novel Coronavirus date: 2020-03-29 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.03.035 sha: doc_id: 307258 cord_uid: 66lwpblq file: cache/cord-307660-onz6vfre.json key: cord-307660-onz6vfre authors: Titanji, Boghuma K; Farley, Monica M; Mehta, Ashish; Connor-Schuler, Randi; Moanna, Abeer; Cribbs, Sushma K; O’Shea, Jesse; DeSilva, Kathryn; Chan, Bonnie; Edwards, Alex; Gavegnano, Christina; Schinazi, Raymond F; Marconi, Vincent C title: Use of Baricitinib in Patients with Moderate and Severe COVID-19 date: 2020-06-29 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa879 sha: doc_id: 307660 cord_uid: onz6vfre file: cache/cord-306896-khn8epxd.json key: cord-306896-khn8epxd authors: D'Souza, Ayman; Simo, Ricard; D'Souza, Alwyn; Vaz, Francis; Prior, Andrew; Kanegaonkar, Rahul title: Tracheostomy intervention in intubated COVID positive patients: A survey of current clinical practice among ENT surgeons date: 2020-06-05 journal: Head Neck DOI: 10.1002/hed.26274 sha: doc_id: 306896 cord_uid: khn8epxd file: cache/cord-307217-0agij3z3.json key: cord-307217-0agij3z3 authors: Sun, Qiulian; Li, Qianyun; Gao, Feng; Li, Jingjing; Xu, Xinjian; Huang, Xiangzhong title: Evolution of computed tomography manifestations of eleven patients with severe coronavirus disease 2019 (COVID‐19) pneumonia date: 2020-08-08 journal: Int J Clin Pract DOI: 10.1111/ijcp.13654 sha: doc_id: 307217 cord_uid: 0agij3z3 file: cache/cord-307653-nyr6mtj1.json key: cord-307653-nyr6mtj1 authors: Palmeira, Patricia; Barbuto, José Alexandre M; Silva, Clovis Artur A; Carneiro-Sampaio, Magda title: Why is SARS-CoV-2 infection milder among children? date: 2020-05-11 journal: Clinics (Sao Paulo) DOI: 10.6061/clinics/2020/e1947 sha: doc_id: 307653 cord_uid: nyr6mtj1 file: cache/cord-307285-bxy0zsc7.json key: cord-307285-bxy0zsc7 authors: Dar Odeh, Najla; Babkair, Hamzah; Abu-Hammad, Shaden; Borzangy, Sary; Abu-Hammad, Abdalla; Abu-Hammad, Osama title: COVID-19: Present and Future Challenges for Dental Practice date: 2020-04-30 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17093151 sha: doc_id: 307285 cord_uid: bxy0zsc7 file: cache/cord-307758-a4sgt66g.json key: cord-307758-a4sgt66g authors: Hong, Ching-Ye; Lin, Raymond TP; Tan, Elaine SL; Chong, Phui-Nah; Tan, Yvette SL; Lew, Yii-Jen; Loo, Liat-Hui title: Acute respiratory symptoms in adults in general practice date: 2004-06-17 journal: Fam Pract DOI: 10.1093/fampra/cmh319 sha: doc_id: 307758 cord_uid: a4sgt66g file: cache/cord-307690-1qqyixun.json key: cord-307690-1qqyixun authors: Preti, Emanuele; Di Pierro, Rossella; Fanti, Erika; Madeddu, Fabio; Calati, Raffaella title: Personality Disorders in Time of Pandemic date: 2020-11-10 journal: Curr Psychiatry Rep DOI: 10.1007/s11920-020-01204-w sha: doc_id: 307690 cord_uid: 1qqyixun file: cache/cord-308071-1bk3xuwf.json key: cord-308071-1bk3xuwf authors: Lang, Christian; Jaksch, Peter; Hoda, Mir Alireza; Lang, György; Staudinger, Thomas; Tschernko, Edda; Zapletal, Bernhard; Geleff, Silvana; Prosch, Helmut; Gawish, Riem; Knapp, Sylvia; Robak, Oliver; Thalhammer, Florian; Indra, Alexander; Koestenberger, Markus; Strassl, Robert; Klikovits, Thomas; Ali, Kamran; Fischer, Gottfried; Klepetko, Walter; Hoetzenecker, Konrad; Schellongowski, Peter title: Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient date: 2020-08-25 journal: Lancet Respir Med DOI: 10.1016/s2213-2600(20)30361-1 sha: doc_id: 308071 cord_uid: 1bk3xuwf file: cache/cord-308010-ix0xi5jb.json key: cord-308010-ix0xi5jb authors: Mcloughlin, Benjamin C.; Miles, Amy; Webb, Thomas E.; Knopp, Paul; Eyres, Clodagh; Fabbri, Ambra; Humphries, Fiona; Davis, Daniel title: Functional and cognitive outcomes after COVID-19 delirium date: 2020-07-14 journal: Eur Geriatr Med DOI: 10.1007/s41999-020-00353-8 sha: doc_id: 308010 cord_uid: ix0xi5jb file: cache/cord-308184-w8ewm8ve.json key: cord-308184-w8ewm8ve authors: Sarzi-Puttini, Piercarlo; Marotto, Daniela; Antivalle, Marco; Salaffi, Fausto; Atzeni, Fabiola; Maconi, Giovanni; Monteleone, Giovanni; Rizzardini, Giuliano; Antinori, Spinello; Galli, Massimo; Ardizzone, Sandro title: How to handle patients with autoimmune rheumatic and inflammatory bowel diseases in the COVID-19 era: An expert opinion date: 2020-05-05 journal: Autoimmun Rev DOI: 10.1016/j.autrev.2020.102574 sha: doc_id: 308184 cord_uid: w8ewm8ve file: cache/cord-308390-ei96iuw3.json key: cord-308390-ei96iuw3 authors: Wu, Junping; Tan, Cherie S.; Yu, Hongzhi; Wang, Youwei; Tian, Yutao; Shao, Wenwei; Zhang, Yifei; Zhang, Kuo; Shao, Hongxia; Ni, Guangjian; Shen, Jun; Galoforo, AntonioCarlo; Wu, Qi; Ming., Dong title: Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy date: 2020-11-04 journal: Innovation (N Y) DOI: 10.1016/j.xinn.2020.100060 sha: doc_id: 308390 cord_uid: ei96iuw3 file: cache/cord-307309-s0t4kp2x.json key: cord-307309-s0t4kp2x authors: Liang, Ying; Chang, Chun; Chen, Yahong; Dong, Fawu; Zhang, Linlin; Sun, Yongchang title: Symptoms, Management and Healthcare Utilization of COPD Patients During the COVID-19 Epidemic in Beijing date: 2020-10-14 journal: Int J Chron Obstruct Pulmon Dis DOI: 10.2147/copd.s270448 sha: doc_id: 307309 cord_uid: s0t4kp2x file: cache/cord-307862-a082sghm.json key: cord-307862-a082sghm authors: ten Cate, Hugo title: Thrombosis management in times of COVID-19 epidemy; a Dutch perspective date: 2020-04-20 journal: Thromb J DOI: 10.1186/s12959-020-00220-3 sha: doc_id: 307862 cord_uid: a082sghm file: cache/cord-308075-1ftswsm8.json key: cord-308075-1ftswsm8 authors: Segura, Patricia Sanz; Lázaro, Yolanda Arguedas; Tapia, Sonia Mostacero; Chaves, Tomás Cabrera; Domingo, Juan José Sebastián title: Involvement of the digestive system in COVID-19. A review date: 2020-10-09 journal: nan DOI: 10.1016/j.gastre.2020.06.004 sha: doc_id: 308075 cord_uid: 1ftswsm8 file: cache/cord-308252-qwoo7b1l.json key: cord-308252-qwoo7b1l authors: Cardinale, Vincenzo; Capurso, Gabriele; Ianiro, Gianluca; Gasbarrini, Antonio; Arcidiacono, Paolo Giorgio; Alvaro, Domenico title: Intestinal permeability changes with bacterial translocation as key events modulating systemic host immune response to SARS-CoV-2: A working hypothesis date: 2020-09-16 journal: Dig Liver Dis DOI: 10.1016/j.dld.2020.09.009 sha: doc_id: 308252 cord_uid: qwoo7b1l file: cache/cord-308112-w96ncfla.json key: cord-308112-w96ncfla authors: Gautret, Philippe; Raoult, Didier title: Nullane salus extra ecclesiam date: 2020-08-01 journal: New Microbes New Infect DOI: 10.1016/j.nmni.2020.100714 sha: doc_id: 308112 cord_uid: w96ncfla file: cache/cord-308169-a0ft6wdy.json key: cord-308169-a0ft6wdy authors: Custovic, A.; Johnston, S. L.; Pavord, I.; Gaga, M.; Fabbri, L.; Bel, E. H.; Le Souëf, P.; Lötvall, J.; Demoly, P.; Akdis, C. A.; Ryan, D.; Mäkelä, M. J.; Martinez, F.; Holloway, J. W.; Saglani, S.; O'Byrne, P.; Papi, A.; Sergejeva, S.; Magnan, A.; Del Giacco, S.; Kalayci, O.; Hamelmann, E.; Papadopoulos, N. G. title: EAACI position statement on asthma exacerbations and severe asthma date: 2013-11-06 journal: Allergy DOI: 10.1111/all.12275 sha: doc_id: 308169 cord_uid: a0ft6wdy file: cache/cord-307287-zpq6byml.json key: cord-307287-zpq6byml authors: Poulsen, Nadia Nicholine; von Brunn, Albrecht; Hornum, Mads; Blomberg Jensen, Martin title: Cyclosporine and COVID‐19: Risk or Favorable? date: 2020-08-10 journal: Am J Transplant DOI: 10.1111/ajt.16250 sha: doc_id: 307287 cord_uid: zpq6byml file: cache/cord-307710-dlpfbnb1.json key: cord-307710-dlpfbnb1 authors: Neradi, Deepak; Hooda, Aman; Shetty, Akshay; Kumar, Deepak; Salaria, Amit Kumar; Goni, Vijay title: Management of Orthopaedic Patients During COVID-19 Pandemic in India: A Guide date: 2020-04-27 journal: Indian J Orthop DOI: 10.1007/s43465-020-00122-6 sha: doc_id: 307710 cord_uid: dlpfbnb1 file: cache/cord-308195-nlibv0u4.json key: cord-308195-nlibv0u4 authors: Arleo, T. L.; Tong, D. C.; Shabto, J. M.; O'Keefe, G. D.; Khosroshahi, A. title: Clinical Course and Outcomes of coronavirus disease 2019 (COVID-19) in Rheumatic Disease Patients on Immunosuppression: A case Cohort Study at a Single Center with a Significantly Diverse Population date: 2020-10-27 journal: nan DOI: 10.1101/2020.10.26.20219154 sha: doc_id: 308195 cord_uid: nlibv0u4 file: cache/cord-308002-abgv87e4.json key: cord-308002-abgv87e4 authors: Porta, Camillo title: Editorial debate: Challenges an oncologist has to face during the SARS-CoV-2 pandemic within a universal healthcare system date: 2020-05-04 journal: ESMO Open DOI: 10.1136/esmoopen-2020-000790 sha: doc_id: 308002 cord_uid: abgv87e4 file: cache/cord-308313-3speddao.json key: cord-308313-3speddao authors: Jaspard, Marie; Butel, Nathalie; El Helali, Najoua; Marigot-Outtandy, Dhiba; Guillot, Helene; Peytavin, Gilles; Veziris, Nicolas; Bodaghi, Bahram; Flandre, Philippe; Petitjean, Gregoire; Caumes, Eric; Pourcher, Valerie title: Linezolid-Associated Neurologic Adverse Events in Patients with Multidrug-Resistant Tuberculosis, France date: 2020-08-17 journal: Emerg Infect Dis DOI: 10.3201/eid2608.191499 sha: doc_id: 308313 cord_uid: 3speddao file: cache/cord-307808-0t6sw0zp.json key: cord-307808-0t6sw0zp authors: Romanick-Schmiedl, Sue; Raghu, Ganesh title: Telemedicine — maintaining quality during times of transition date: 2020-06-01 journal: Nat Rev Dis Primers DOI: 10.1038/s41572-020-0185-x sha: doc_id: 307808 cord_uid: 0t6sw0zp file: cache/cord-308466-f0iu6sje.json key: cord-308466-f0iu6sje authors: Ko, Fanny W.; Chan, Ka Pang; Hui, David S.; Goddard, John R.; Shaw, Janet G.; Reid, David W.; Yang, Ian A. title: Acute exacerbation of COPD date: 2016-03-30 journal: Respirology DOI: 10.1111/resp.12780 sha: doc_id: 308466 cord_uid: f0iu6sje file: cache/cord-308907-elz62jlg.json key: cord-308907-elz62jlg authors: Joob, Beuy; Wiwanitkit, Viroj title: 2019 Novel coronavirus and awareness date: 2020-05-04 journal: J Chin Med Assoc DOI: 10.1097/jcma.0000000000000306 sha: doc_id: 308907 cord_uid: elz62jlg file: cache/cord-308212-l8flyso7.json key: cord-308212-l8flyso7 authors: Kong, Ha Eun; Grant-Kels, Jane M.; Stoff, Benjamin K. title: Applying the ethical principles of resource allocation to drugs in limited supply during a public health crisis date: 2020-04-21 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.04.078 sha: doc_id: 308212 cord_uid: l8flyso7 file: cache/cord-308491-fc46k594.json key: cord-308491-fc46k594 authors: Mossa-Basha, Mahmud; Medverd, Jonathan; Linnau, Kenneth; Lynch, John B.; Wener, Mark H.; Kicska, Gregory; Staiger, Thomas; Sahani, Dushyant title: Policies and Guidelines for COVID-19 Preparedness: Experiences from the University of Washington date: 2020-04-08 journal: Radiology DOI: 10.1148/radiol.2020201326 sha: doc_id: 308491 cord_uid: fc46k594 file: cache/cord-308445-3j2q83ll.json key: cord-308445-3j2q83ll authors: Rhim, Jung-Woo; Go, Eun-Ji; Lee, Kyung-Yil; Youn, You-Sook; Kim, Myung-Sook; Park, Sun Hee; Kim, Ji-Chang; Kang, Jin-Han title: Pandemic 2009 H1N1 virus infection in children and adults: A cohort study at a single hospital throughout the epidemic date: 2012-03-26 journal: Int Arch Med DOI: 10.1186/1755-7682-5-13 sha: doc_id: 308445 cord_uid: 3j2q83ll file: cache/cord-308906-et7duogt.json key: cord-308906-et7duogt authors: Di, Gaohong; Xia, Chengkun; Yao, Shanglong; Chen, Xiangdong; Wu, Zhilin; Hu, Ling; Wang, Jie title: Simple and Effective Primary Assessment of Emergency Patients in a COVID-19 Outbreak Area: A Retrospective, Observational Study date: 2020-08-20 journal: Risk Manag Healthc Policy DOI: 10.2147/rmhp.s263950 sha: doc_id: 308906 cord_uid: et7duogt file: cache/cord-309207-n8u8ddv7.json key: cord-309207-n8u8ddv7 authors: Lechien, Jerome R.; Chiesa-Estomba MD, Carlos M.; Hans, Stephane; Barillari MD, Maria Rosaria; Jouffe, Lionel; Saussez, Sven title: Loss of Smell and Taste in 2013 European Patients With Mild to Moderate COVID-19 date: 2020-05-26 journal: Ann Intern Med DOI: 10.7326/m20-2428 sha: doc_id: 309207 cord_uid: n8u8ddv7 file: cache/cord-309214-v2iqgjc4.json key: cord-309214-v2iqgjc4 authors: Nougier, Christophe; Benoit, Remi; Simon, Marie; Desmurs‐Clavel, Helene; Marcotte, Guillaume; Argaud, Laurent; David, Jean Stephane; Bonnet, Aurelie; Negrier, Claude; Dargaud, Yesim title: Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis date: 2020-07-15 journal: J Thromb Haemost DOI: 10.1111/jth.15016 sha: doc_id: 309214 cord_uid: v2iqgjc4 file: cache/cord-308979-qhlvd2mt.json key: cord-308979-qhlvd2mt authors: Sumino, Kaharu C.; Agapov, Eugene; Pierce, Richard A.; Trulock, Elbert P.; Pfeifer, John D.; Ritter, Jon H.; Gaudreault-Keener, Monique; Storch, Gregory A.; Holtzman, Michael J. title: Detection of Severe Human Metapneumovirus Infection by Real-Time Polymerase Chain Reaction and Histopathological Assessment date: 2005-09-15 journal: J Infect Dis DOI: 10.1086/432728 sha: doc_id: 308979 cord_uid: qhlvd2mt file: cache/cord-309024-pu830bn9.json key: cord-309024-pu830bn9 authors: Bernardo, Luca; Del Sesto, Stefania; Giordano, Laura; Benincaso, Anna Rita; Biondi, Piero; Goj, Vinicio; Ferrara, Francesca; Talenti, Antonella; Grisolia, Antonella; Ascierto, Paolo Antonio title: Severe prolonged neutropenia following administration of tocilizumab in a patient affected by COVID-19: a case report and brief review of the literature date: 2020-09-14 journal: Drugs Ther Perspect DOI: 10.1007/s40267-020-00777-z sha: doc_id: 309024 cord_uid: pu830bn9 file: cache/cord-309236-p4c2d5y3.json key: cord-309236-p4c2d5y3 authors: Khurram, Ruhaid; Johnson, Franklin T F; Naran, Revati; Hare, Samanjit title: Spontaneous tension pneumothorax and acute pulmonary emboli in a patient with COVID-19 infection date: 2020-08-11 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-237475 sha: doc_id: 309236 cord_uid: p4c2d5y3 file: cache/cord-309001-erm705tg.json key: cord-309001-erm705tg authors: Liu, Q.; Song, N. C.; Zheng, Z. K.; Li, J. S.; Li, S. K. title: Laboratory findings and a combined multifactorial approach to predict death in critically ill patients with COVID-19: a retrospective study date: 2020-06-30 journal: Epidemiol Infect DOI: 10.1017/s0950268820001442 sha: doc_id: 309001 cord_uid: erm705tg file: cache/cord-309194-jtouafgd.json key: cord-309194-jtouafgd authors: Lu, Xiao; Zhang, Mao; Qian, Anyu; Tang, Luping; Xu, Shanxiang title: Lung ultrasound score in establishing the timing of intubation in COVID-19 interstitial pneumonia: A preliminary retrospective observational study date: 2020-09-03 journal: PLoS One DOI: 10.1371/journal.pone.0238679 sha: doc_id: 309194 cord_uid: jtouafgd file: cache/cord-308803-i934doud.json key: cord-308803-i934doud authors: PONNAPA REDDY, M.; SUBRAMANIAM, A.; LIM, Z. J.; ZUBAREV, A.; AFROZ, A.; BILLAH, B.; TIRUVOIPATI, R.; RAMANATHAN, K.; WONG, S. N.; BRODIE, D.; FAN, E.; SHEKAR, K. title: Prone positioning of non-intubated patients with COVID-19 - A Systematic Review and Meta-analysis date: 2020-10-14 journal: nan DOI: 10.1101/2020.10.12.20211748 sha: doc_id: 308803 cord_uid: i934doud file: cache/cord-309370-g8d3w7it.json key: cord-309370-g8d3w7it authors: Insausti-García, Alfredo; Reche-Sainz, José Alberto; Ruiz-Arranz, Celia; López Vázquez, Ángel; Ferro-Osuna, Manuel title: Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state date: 2020-07-30 journal: Eur J Ophthalmol DOI: 10.1177/1120672120947591 sha: doc_id: 309370 cord_uid: g8d3w7it file: cache/cord-308968-m4pzsfkd.json key: cord-308968-m4pzsfkd authors: Mercadante, Amanda R.; Yokota, Mai; Hwang, Angela; Hata, Micah; Law, Anandi V. title: Choosing Evolution over Extinction: Integrating Direct Patient Care Services and Value-Based Payment Models into the Community-Based Pharmacy Setting date: 2020-07-24 journal: Pharmacy (Basel) DOI: 10.3390/pharmacy8030128 sha: doc_id: 308968 cord_uid: m4pzsfkd file: cache/cord-309421-725u6dau.json key: cord-309421-725u6dau authors: Wechsler, Michael E.; Colice, Gene; Griffiths, Janet M.; Almqvist, Gun; Skärby, Tor; Piechowiak, Teresa; Kaur, Primal; Bowen, Karin; Hellqvist, Åsa; Mo, May; Garcia Gil, Esther title: SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma date: 2020-10-13 journal: Respir Res DOI: 10.1186/s12931-020-01503-z sha: doc_id: 309421 cord_uid: 725u6dau file: cache/cord-309395-5yan9fcn.json key: cord-309395-5yan9fcn authors: Kazory, Amir; Ronco, Claudio; McCullough, Peter A. title: SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill date: 2020-04-16 journal: Proc (Bayl Univ Med Cent) DOI: 10.1080/08998280.2020.1754700 sha: doc_id: 309395 cord_uid: 5yan9fcn file: cache/cord-309026-l2rh9bie.json key: cord-309026-l2rh9bie authors: Sweiss, Nadera J.; Korsten, Peter; Syed, Huzaefah; Syed, Aamer; Baughman, Robert P.; Yee, Arthur M.F.; Culver, Daniel A.; Sosenko, Teresa; Azuma, Arata; Bonella, Francesco; Costabel, Ulrich; Drake, Wonder P.; Drent, Marjolein; Lower, Elyse E.; Israel-Biet, Dominique; Mostard, Remy LM.; Nunes, Hilario; Rottoli, Paola; Spagnolo, Paolo; Wells, Athol U.; Wuyts, Wim A.; Judson, Marc A. title: When the game changes: Guidance to adjust sarcoidosis management during the COVID-19 pandemic date: 2020-04-29 journal: Chest DOI: 10.1016/j.chest.2020.04.033 sha: doc_id: 309026 cord_uid: l2rh9bie file: cache/cord-309441-obojsf04.json key: cord-309441-obojsf04 authors: Pirau, Letitia; Ottenhoff, Lauren; Williamson, Craig A.; Ahmad, Shahid N.; Wabl, Rafael; Nguyen, Andrew; Faiver, Laura; Rajajee, Venkatakrishna title: Case Series: Evidence of Borderzone Ischemia in Critically-Ill COVID-19 Patients Who “Do Not Wake Up” date: 2020-09-23 journal: Front Neurol DOI: 10.3389/fneur.2020.00964 sha: doc_id: 309441 cord_uid: obojsf04 file: cache/cord-309302-n6cd2fc3.json key: cord-309302-n6cd2fc3 authors: Wang, Li; Jiang, Man; Qu, Jialin; Zhou, Na; Zhang, Xiaochun title: Clinical management of lung cancer patients during the outbreak of COVID-19 epidemic date: 2020-09-23 journal: Infect Agent Cancer DOI: 10.1186/s13027-020-00322-7 sha: doc_id: 309302 cord_uid: n6cd2fc3 file: cache/cord-309561-m43v332d.json key: cord-309561-m43v332d authors: Cuffaro, Luca; Di Lorenzo, Francesco; Bonavita, Simona; Tedeschi, Gioacchino; Leocani, Letizia; Lavorgna, Luigi title: Dementia care and COVID-19 pandemic: a necessary digital revolution date: 2020-06-17 journal: Neurol Sci DOI: 10.1007/s10072-020-04512-4 sha: doc_id: 309561 cord_uid: m43v332d file: cache/cord-309323-yflng8m3.json key: cord-309323-yflng8m3 authors: Thomas, T.; Stefanoni, D.; Reisz, J. A.; Nemkov, T.; Bertolone, L.; Francis, R. O.; Hudson, K. E.; Zimring, J. C.; Hansen, K. C.; Hod, E. A.; Spitalnik, S. L.; D'Alessandro, A. title: COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status date: 2020-05-16 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.05.14.20102491 sha: doc_id: 309323 cord_uid: yflng8m3 file: cache/cord-309507-oe4i6v5x.json key: cord-309507-oe4i6v5x authors: Sacchelli, L.; Viviani, F.; Orioni, G.; Rucci, P.; Rosa, S.; Lanzoni, A.; Patrizi, A.; Gaspari, V. title: Sexually Transmitted Infections during the COVID‐19 outbreak: comparison of patients referring to the service of sexually transmitted diseases during the sanitary emergency with those referring during the common practice date: 2020-06-03 journal: J Eur Acad Dermatol Venereol DOI: 10.1111/jdv.16694 sha: doc_id: 309507 cord_uid: oe4i6v5x file: cache/cord-309482-frawgvk7.json key: cord-309482-frawgvk7 authors: Cook, T. M.; Harrop‐Griffiths, W. title: Kicking on while it’s still kicking off – getting surgery and anaesthesia restarted after COVID‐19 date: 2020-06-01 journal: Anaesthesia DOI: 10.1111/anae.15128 sha: doc_id: 309482 cord_uid: frawgvk7 file: cache/cord-309751-7elnvjk3.json key: cord-309751-7elnvjk3 authors: Abdelnasser, Mohammad Kamal; Morsy, Mohamed; Osman, Ahmed E.; AbdelKawi, Ayman F.; Ibrahim, Mahmoud Fouad; Eisa, Amr; Fadle, Amr A.; Hatem, Amr; Anter Abdelhameed, Mohammed; Hassan, Ahmed Abdelazim A.; Shawky Abdelgawaad, Ahmed title: COVID-19. An update for orthopedic surgeons date: 2020-07-01 journal: SICOT-J DOI: 10.1051/sicotj/2020022 sha: doc_id: 309751 cord_uid: 7elnvjk3 file: cache/cord-309238-7lbt0f03.json key: cord-309238-7lbt0f03 authors: Koratala, Abhilash; Ronco, Claudio; Kazory, Amir title: Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19: The Tri-POCUS Approach date: 2020-05-27 journal: Cardiorenal Med DOI: 10.1159/000508544 sha: doc_id: 309238 cord_uid: 7lbt0f03 file: cache/cord-309360-cpis1l4u.json key: cord-309360-cpis1l4u authors: Barrios-López, J. M.; Rego-García, I.; Muñoz Martínez, C.; Romero-Fábrega, J. C.; Rivero Rodríguez, M.; Ruiz Giménez, J. A.; Escamilla-Sevilla, F.; Mínguez-Castellanos, A.; Fernández Pérez, M. D. title: Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association? date: 2020-05-28 journal: nan DOI: 10.1016/j.nrleng.2020.05.008 sha: doc_id: 309360 cord_uid: cpis1l4u file: cache/cord-309706-kikx05dj.json key: cord-309706-kikx05dj authors: MacDonald, Scott; Kovacs, George; Witter, Tobias; Leroux, Yves; Crocker, Steven; Richards, Lindsay title: Implementing a 2019 coronavirus disease airway management strategy for a provincial critical care and ground transport program date: 2020-06-03 journal: CJEM DOI: 10.1017/cem.2020.413 sha: doc_id: 309706 cord_uid: kikx05dj file: cache/cord-309728-7vfotgrr.json key: cord-309728-7vfotgrr authors: Johnson, Kristen M.; Belfer, Julie J.; Peterson, Gina R.; Boelkins, Mark R.; Dumkow, Lisa E. title: Managing COVID‐19 in Renal Transplant Recipients: A Review of Recent Literature and Case Supporting Corticosteroid‐sparing Immunosuppression date: 2020-05-26 journal: Pharmacotherapy DOI: 10.1002/phar.2410 sha: doc_id: 309728 cord_uid: 7vfotgrr file: cache/cord-309829-3dlfcy31.json key: cord-309829-3dlfcy31 authors: Parupudi, Tejasvi; Panchagnula, Neha; Muthukumar, Sriram; Prasad, Shalini title: Evidence-based point-of-care technology development during the COVID-19 pandemic date: 2020-11-09 journal: BioTechniques DOI: 10.2144/btn-2020-0096 sha: doc_id: 309829 cord_uid: 3dlfcy31 file: cache/cord-310010-oxgb6xnv.json key: cord-310010-oxgb6xnv authors: Dalmau, Josep title: “Time to recharge” date: 2020-06-11 journal: Neurol Neuroimmunol Neuroinflamm DOI: 10.1212/nxi.0000000000000779 sha: doc_id: 310010 cord_uid: oxgb6xnv file: cache/cord-309735-bwa1zo07.json key: cord-309735-bwa1zo07 authors: Cerfolio, Robert J. title: Many Ways to Skin A Cat date: 2020-07-24 journal: Ann Thorac Surg DOI: 10.1016/j.athoracsur.2020.07.006 sha: doc_id: 309735 cord_uid: bwa1zo07 file: cache/cord-309962-phwq8rsf.json key: cord-309962-phwq8rsf authors: Vetter, Monica Hagan; Smrz, Stacy A.; Copeland, Larry J.; Cohn, David E. title: Chemotherapy directly followed by PARP inhibition as an alternative to surgery in patients with BRCA- mutated ovarian cancer – a potential management strategy in the era of COVID-19 date: 2020-05-23 journal: Am J Obstet Gynecol DOI: 10.1016/j.ajog.2020.05.037 sha: doc_id: 309962 cord_uid: phwq8rsf file: cache/cord-310117-19qsszns.json key: cord-310117-19qsszns authors: Huang, Yao; Chen, Zhe; Wang, Yu; Han, Liang; Qin, Kai; Huang, Wenya; Huang, Ying; Wang, Hui; Shen, Pan; Ba, Xin; Lin, Weiji; Dong, Hui; Zhang, Mingmin; Tu, Shenghao title: Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study date: 2020-06-16 journal: Ann Rheum Dis DOI: 10.1136/annrheumdis-2020-217425 sha: doc_id: 310117 cord_uid: 19qsszns file: cache/cord-310069-ay4af6xr.json key: cord-310069-ay4af6xr authors: Tobin, Martin J. title: Does making a diagnosis of ARDS in COVID-19 patients matter? date: 2020-07-21 journal: Chest DOI: 10.1016/j.chest.2020.07.028 sha: doc_id: 310069 cord_uid: ay4af6xr file: cache/cord-309517-yh4d414y.json key: cord-309517-yh4d414y authors: Yu, Chao; Zhou, Miao; Liu, Yang; Guo, Tinglin; Ou, Chongyang; Yang, Liye; Li, Yan; Li, Dongliang; Hu, Xinyu; Shuai, Li; Wang, Bin; Zou, Zui title: Characteristics of asymptomatic COVID-19 infection and progression: A multicenter, retrospective study date: 2020-08-12 journal: Virulence DOI: 10.1080/21505594.2020.1802194 sha: doc_id: 309517 cord_uid: yh4d414y file: cache/cord-310166-gt6icwul.json key: cord-310166-gt6icwul authors: Yang, Xiang-Hong; Sun, Ren-Hua; Zhao, Ming-Yan; Chen, Er-Zhen; Liu, Jiao; Wang, Hong-Liang; Yang, Rong-Li; Chen, De-Chang title: Expert recommendations on blood purification treatment protocol for patients with severe COVID-19(): Recommendation and consensus date: 2020-04-28 journal: Chronic Dis Transl Med DOI: 10.1016/j.cdtm.2020.04.002 sha: doc_id: 310166 cord_uid: gt6icwul file: cache/cord-310240-otf9ruvj.json key: cord-310240-otf9ruvj authors: Prohaska, Stefanie; Schirner, Andrea; Bashota, Albina; Körner, Andreas; Blumenstock, Gunnar; Haeberle, Helene A. title: Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy date: 2018-02-26 journal: J Intensive Care DOI: 10.1186/s40560-018-0278-8 sha: doc_id: 310240 cord_uid: otf9ruvj file: cache/cord-310001-qng7h5cj.json key: cord-310001-qng7h5cj authors: Tomlins, Jennifer; Hamilton, Fergus; Gunning, Samuel; Sheehy, Caitlin; Moran, Ed; Macgowan, Alastair title: Clinical features of 95 sequential hospitalised patients with novel coronavirus 2019 disease (COVID-19), the first UK cohort date: 2020-04-27 journal: J Infect DOI: 10.1016/j.jinf.2020.04.020 sha: doc_id: 310001 cord_uid: qng7h5cj file: cache/cord-310597-zy6ckr53.json key: cord-310597-zy6ckr53 authors: Essa, Hani; Dobson, Rebecca; Wright, David; Lip, Gregory Y. H. title: Hypertension management in cardio-oncology date: 2020-08-03 journal: J Hum Hypertens DOI: 10.1038/s41371-020-0391-8 sha: doc_id: 310597 cord_uid: zy6ckr53 file: cache/cord-310661-hrvuhkq9.json key: cord-310661-hrvuhkq9 authors: Patell, Rushad; Bogue, Thomas; Bindal, Poorva; Koshy, Anita; Merrill, Mwanasha; Aird, William C; Bauer, Kenneth A; Zwicker, Jeffrey I title: Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID‐19 date: 2020-07-21 journal: J Thromb Haemost DOI: 10.1111/jth.15018 sha: doc_id: 310661 cord_uid: hrvuhkq9 file: cache/cord-310891-yfouizjb.json key: cord-310891-yfouizjb authors: Korada, Sai Krishna C.; Mann, James A.; Hasan, Ayesha K.; Baliga, Ragavendra R.; Mokadam, Nahush A.; Benza, Raymond L.; Vallakati, Ajay title: Management of COVID-19 in a Durable Left Ventricular Assist Device Recipient: A Continuity of Care Perspective date: 2020-08-20 journal: Heart Lung DOI: 10.1016/j.hrtlng.2020.08.012 sha: doc_id: 310891 cord_uid: yfouizjb file: cache/cord-310405-7fah22nu.json key: cord-310405-7fah22nu authors: Mathur, Sachin; Jeremy Ng, Chung Fai; Koh, Fangju; Cai, Mingzhe; Palaniappan, Gautham; Linn, Yun Le; Lim, Huiling Linda; Lakshman, Ramu; Ling, Xiao Shuang; Chin, Sock Teng; Tan, Hiang Khoon title: Development of an enhanced Acute Care Surgery service in response to the COVID-19 global pandemic: Assessment of clinical patient outcomes and staff psychological well-being date: 2020-06-25 journal: Injury DOI: 10.1016/j.injury.2020.06.040 sha: doc_id: 310405 cord_uid: 7fah22nu file: cache/cord-310084-taaz6mhs.json key: cord-310084-taaz6mhs authors: Fatehi, Poya; Hesam-Shariati, Negin; Abouzaripour, Morteza; Fathi, Fardin; Hesam Shariati, Mohammad Bakhtiar title: Acute Ischemic and Hemorrhagic Stroke and COVID-19: Case Series date: 2020-10-01 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00559-8 sha: doc_id: 310084 cord_uid: taaz6mhs file: cache/cord-310690-50z2kdaj.json key: cord-310690-50z2kdaj authors: Maschmeyer, Georg; Donnelly, J. Peter title: How to manage lung infiltrates in adults suffering from haematological malignancies outside allogeneic haematopoietic stem cell transplantation date: 2016-01-05 journal: Br J Haematol DOI: 10.1111/bjh.13934 sha: doc_id: 310690 cord_uid: 50z2kdaj file: cache/cord-310823-xksu8fn1.json key: cord-310823-xksu8fn1 authors: Anand, Abhinav; Kumar, Ramesh; Shalimar, title: Obesity and mortality in COVID-19: cause or association? date: 2020-09-16 journal: Gastroenterology DOI: 10.1053/j.gastro.2020.08.055 sha: doc_id: 310823 cord_uid: xksu8fn1 file: cache/cord-310974-hz37yf39.json key: cord-310974-hz37yf39 authors: Crolley, Valerie E.; Hanna, Daire; Joharatnam-Hogan, Nalinie; Chopra, Neha; Bamac, Ekin; Desai, Meera; Lam, Yuk-Chun; Dipro, Sabiq; Kanani, Ruhi; Benson, Jack; Wilson, William; Fox, Thomas A.; Shiu, Kai-Keen; Forster, Martin; Bridgewater, John; Hochhauser, Daniel; Khan, Khurum title: COVID-19 in cancer patients on systemic anti-cancer therapies: outcomes from the CAPITOL (COVID-19 Cancer PatIenT Outcomes in North London) cohort study date: 2020-10-23 journal: Ther Adv Med Oncol DOI: 10.1177/1758835920971147 sha: doc_id: 310974 cord_uid: hz37yf39 file: cache/cord-310205-j57x9ke6.json key: cord-310205-j57x9ke6 authors: Alcaide, Maria L.; Bisno, Alan L. title: Pharyngitis and Epiglottitis date: 2007-06-08 journal: Infect Dis Clin North Am DOI: 10.1016/j.idc.2007.03.001 sha: doc_id: 310205 cord_uid: j57x9ke6 file: cache/cord-310539-8zk3hkgj.json key: cord-310539-8zk3hkgj authors: Barengolts, Elena title: PERSEVERE OR PERIL: DIABETES CARE IN TIMES OF COVID-19 date: 2020-08-08 journal: Endocr Pract DOI: 10.4158/ep-2020-0227 sha: doc_id: 310539 cord_uid: 8zk3hkgj file: cache/cord-310663-504p29hv.json key: cord-310663-504p29hv authors: Gambardella, Jessica; Khondkar, Wafiq; Morelli, Marco Bruno; Wang, Xujun; Santulli, Gaetano; Trimarco, Valentina title: Arginine and Endothelial Function date: 2020-08-06 journal: Biomedicines DOI: 10.3390/biomedicines8080277 sha: doc_id: 310663 cord_uid: 504p29hv file: cache/cord-310901-oooat8xj.json key: cord-310901-oooat8xj authors: Arca, Karissa N.; Smith, Jonathan H.; Chiang, Chia‐Chun; Starling, Amaal J.; Robertson, Carrie E.; Halker Singh, Rashmi B.; Schwedt, Todd J.; Kissoon, Narayan R.; Garza, Ivan; Rozen, Todd D.; Boes, Christoper J.; Whealy, Mark A.; VanderPluym, Juliana H. title: COVID‐19 and Headache Medicine: A Narrative Review of Non‐Steroidal Anti‐Inflammatory Drug (NSAID) and Corticosteroid Use date: 2020-07-10 journal: Headache DOI: 10.1111/head.13903 sha: doc_id: 310901 cord_uid: oooat8xj file: cache/cord-310177-4jw1lkli.json key: cord-310177-4jw1lkli authors: Simcock, R.; Wright, J. title: Beyond Performance Status date: 2020-07-16 journal: Clin Oncol (R Coll Radiol) DOI: 10.1016/j.clon.2020.06.016 sha: doc_id: 310177 cord_uid: 4jw1lkli file: cache/cord-310902-cfci8lef.json key: cord-310902-cfci8lef authors: Freites Nuñez, Dalifer D; Leon, Leticia; Mucientes, Arkaitz; Rodriguez-Rodriguez, Luis; Font Urgelles, Judit; Madrid García, Alfredo; Colomer, Jose I; Jover, Juan A; Fernandez-Gutierrez, Benjamín; Abasolo, Lydia title: Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases date: 2020-08-07 journal: Ann Rheum Dis DOI: 10.1136/annrheumdis-2020-217984 sha: doc_id: 310902 cord_uid: cfci8lef file: cache/cord-310976-24b3c3a4.json key: cord-310976-24b3c3a4 authors: Parikh, Neil R.; Chang, Eric M.; Kishan, Amar U.; Kaprealian, Tania B.; Steinberg, Michael L.; Raldow, Ann C. title: Time-Driven Activity-Based Costing Analysis of Telemedicine Services in Radiation Oncology date: 2020-10-01 journal: Int J Radiat Oncol Biol Phys DOI: 10.1016/j.ijrobp.2020.06.053 sha: doc_id: 310976 cord_uid: 24b3c3a4 file: cache/cord-311043-nidu7om2.json key: cord-311043-nidu7om2 authors: Erdinc, Burak; Raina, Jilmil S title: Spontaneous Retroperitoneal Bleed Coincided With Massive Acute Deep Vein Thrombosis as Initial Presentation of COVID-19 date: 2020-08-15 journal: Cureus DOI: 10.7759/cureus.9772 sha: doc_id: 311043 cord_uid: nidu7om2 file: cache/cord-311275-ysr9nqun.json key: cord-311275-ysr9nqun authors: Chuaychoo, Benjamas; Ngamwongwan, Sopita; Kaewnaphan, Bualan; Athipanyasilp, Niracha; Horthongkham, Navin; Kantakamalakul, Wannee; Muangman, Nisa title: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients date: 2019-07-03 journal: J Clin Virol DOI: 10.1016/j.jcv.2019.07.001 sha: doc_id: 311275 cord_uid: ysr9nqun file: cache/cord-311341-7ox30d2u.json key: cord-311341-7ox30d2u authors: Goenka, Anuj; Ma, Daniel; Teckie, Sewit; Alfano, Catherine; Bloom, Beatrice; Hwang, Jamie; Potters, Louis title: Implementation of Telehealth in Radiation Oncology: Rapid Integration During COVID-19 and its Future Role in our Practice date: 2020-10-09 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.09.015 sha: doc_id: 311341 cord_uid: 7ox30d2u file: cache/cord-311074-j3fw4dfc.json key: cord-311074-j3fw4dfc authors: Alviset, Sophie; Riller, Quentin; Aboab, Jérôme; Dilworth, Kelly; Billy, Pierre-Antoine; Lombardi, Yannis; Azzi, Mathilde; Ferreira Vargas, Luis; Laine, Laurent; Lermuzeaux, Mathilde; Mémain, Nathalie; Silva, Daniel; Tchoubou, Tona; Ushmorova, Daria; Dabbagh, Hanane; Escoda, Simon; Lefrançois, Rémi; Nardi, Annelyse; Ngima, Armand; Ioos, Vincent title: Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study date: 2020-10-14 journal: PLoS One DOI: 10.1371/journal.pone.0240645 sha: doc_id: 311074 cord_uid: j3fw4dfc file: cache/cord-310676-125o0o7x.json key: cord-310676-125o0o7x authors: Liu, Qibin; Fang, Xuemin; Tokuno, Shinichi; Chung, Ungil; Chen, Xianxiang; Dai, Xiyong; Liu, Xiaoyu; Xu, Feng; Wang, Bing; Peng, Peng title: Prediction of the clinical outcome of COVID-19 patients using T lymphocyte subsets with 340 cases from Wuhan, China: a retrospective cohort study and a web visualization tool date: 2020-04-11 journal: nan DOI: 10.1101/2020.04.06.20056127 sha: doc_id: 310676 cord_uid: 125o0o7x file: cache/cord-311373-ngs7baoc.json key: cord-311373-ngs7baoc authors: Hu, Nannan; Mao, Hongjing title: Emergency Management of Mental Hospitals during the Outbreak of COVID-19 date: 2020-05-08 journal: Psychiatry Investig DOI: 10.30773/pi.2020.0086 sha: doc_id: 311373 cord_uid: ngs7baoc file: cache/cord-310685-gi2ycrfk.json key: cord-310685-gi2ycrfk authors: Geiling, James title: Critical Care of the Morbidly Obese in Disaster date: 2010-10-31 journal: Critical Care Clinics DOI: 10.1016/j.ccc.2010.06.001 sha: doc_id: 310685 cord_uid: gi2ycrfk file: cache/cord-310917-9sk8gdh8.json key: cord-310917-9sk8gdh8 authors: Ahmed, Kamran; Hayat, Sulaiman; Dasgupta, Prokar title: Global challenges to urology practice during the COVID‐19 pandemic date: 2020-05-15 journal: BJU Int DOI: 10.1111/bju.15082 sha: doc_id: 310917 cord_uid: 9sk8gdh8 file: cache/cord-310779-4puiao40.json key: cord-310779-4puiao40 authors: Mehta, Pooja; Stahl, Marisa G.; Germone, Monique M.; Nagle, Sadie; Guigli, Rebecca; Thomas, Jacob; Shull, Mary; Liu, Edwin title: Telehealth and Nutrition Support During the Covid-19 Pandemic date: 2020-07-14 journal: J Acad Nutr Diet DOI: 10.1016/j.jand.2020.07.013 sha: doc_id: 310779 cord_uid: 4puiao40 file: cache/cord-311044-kjx0z1hc.json key: cord-311044-kjx0z1hc authors: Rubio-Pérez, Inés; Badía, Josep M.; Mora-Rillo, Marta; Quirós, Alejandro Martín; Rodríguez, Julio García; Balibrea, Jose M. title: COVID-19: key concepts for the surgeon date: 2020-05-28 journal: nan DOI: 10.1016/j.cireng.2020.05.009 sha: doc_id: 311044 cord_uid: kjx0z1hc file: cache/cord-311176-dlwph5za.json key: cord-311176-dlwph5za authors: Alshahrani, Mohammed S.; Sindi, Anees; Alshamsi, Fayez; Al-Omari, Awad; El Tahan, Mohamed; Alahmadi, Bayan; Zein, Ahmed; Khatani, Naif; Al-Hameed, Fahad; Alamri, Sultan; Abdelzaher, Mohammed; Alghamdi, Amenah; Alfousan, Faisal; Tash, Adel; Tashkandi, Wail; Alraddadi, Rajaa; Lewis, Kim; Badawee, Mohammed; Arabi, Yaseen M.; Fan, Eddy; Alhazzani, Waleed title: Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus date: 2018-01-10 journal: Ann Intensive Care DOI: 10.1186/s13613-017-0350-x sha: doc_id: 311176 cord_uid: dlwph5za file: cache/cord-311730-189vax2m.json key: cord-311730-189vax2m authors: Becker, Richard C. title: Covid-19 treatment update: follow the scientific evidence date: 2020-04-27 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02120-9 sha: doc_id: 311730 cord_uid: 189vax2m file: cache/cord-311579-4jhoatkw.json key: cord-311579-4jhoatkw authors: Bhatt, Harshil; Singh, Sandeep title: Venous thromboembolism and COVID-19: a case report and review of the literature date: 2020-10-15 journal: J Med Case Rep DOI: 10.1186/s13256-020-02516-4 sha: doc_id: 311579 cord_uid: 4jhoatkw file: cache/cord-311673-z4hkw17g.json key: cord-311673-z4hkw17g authors: Uzzan, Mathieu; Corcos, Olivier; Martin, Jerome; Treton, Xavier; Bouhnik, Yoram title: Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - lung axis hypothesis date: 2020-06-23 journal: Med Hypotheses DOI: 10.1016/j.mehy.2020.110023 sha: doc_id: 311673 cord_uid: z4hkw17g file: cache/cord-311682-npi03i7q.json key: cord-311682-npi03i7q authors: Malicki, J; Martenka, P; Dyzmann-Sroka, A; Paczkowska, K; Leporowska, E; Suchorska, W; Lamperska, K; Pieńkowski, P; Chicheł, A; Mocydlarz-Adamcewicz, M; Urbaniak, D; Bajon, T; Cybulski, Z; Bąk, B; Machtyl, A; Adamska, K; Kaźmierska, J; Milecki, P; Marszałek, A title: Impact of COVID-19 on the performance of a radiation oncology department at a major comprehensive cancer centre in Poland during the first ten weeks of the epidemic date: 2020-08-16 journal: Rep Pract Oncol Radiother DOI: 10.1016/j.rpor.2020.08.001 sha: doc_id: 311682 cord_uid: npi03i7q file: cache/cord-311752-stqrf50k.json key: cord-311752-stqrf50k authors: Akbariqomi, Mostafa; Sadat Hosseini, Mahboobeh; Rashidiani, Jamal; Sedighian, Hamid; Biganeh, Hossein; Heidari, Reza; Moosazadeh Moghaddam, Mehrdad; Farnoosh, Gholamreza; Kooshki, Hamid title: Clinical characteristics and outcome of hospitalized COVID-19 patients with diabetes: A single-center, retrospective study in Iran date: 2020-09-24 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108467 sha: doc_id: 311752 cord_uid: stqrf50k file: cache/cord-311215-x3b7ewo2.json key: cord-311215-x3b7ewo2 authors: Chao, Tiffany N.; Braslow, Benjamin M.; Martin, Niels D.; Chalian, Ara A.; Atkins, J.; Haas, Andrew R.; Rassekh, Christopher H. title: Tracheotomy in Ventilated Patients With COVID-19 date: 2020-05-05 journal: Ann Surg DOI: 10.1097/sla.0000000000003956 sha: doc_id: 311215 cord_uid: x3b7ewo2 file: cache/cord-311848-8n9ee57a.json key: cord-311848-8n9ee57a authors: Giesen, Nicola; Sprute, Rosanne; Rüthrich, Maria; Khodamoradi, Yascha; Mellinghoff, Sibylle C.; Beutel, Gernot; Lueck, Catherina; Koldehoff, Michael; Hentrich, Marcus; Sandherr, Michael; Bergwelt-Baildon, Michael von; Wolf, Hans-Heinrich; Hirsch, Hans H.; Wörmann, Bernhard; Cornely, Oliver A.; Köhler, Philipp; Schalk, Enrico; Lilienfeld-Toal, Marie von title: Evidence-based Management of COVID-19 in Cancer Patients – Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) date: 2020-09-21 journal: Eur J Cancer DOI: 10.1016/j.ejca.2020.09.009 sha: doc_id: 311848 cord_uid: 8n9ee57a file: cache/cord-311970-o9xao5rl.json key: cord-311970-o9xao5rl authors: Ayerbe, Luis; Risco, Carlos; Ayis, Salma title: The association between treatment with heparin and survival in patients with Covid-19 date: 2020-05-31 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02162-z sha: doc_id: 311970 cord_uid: o9xao5rl file: cache/cord-311942-oju4gosw.json key: cord-311942-oju4gosw authors: Grewal, Parneet; Pinna, Pranusha; Hall, Julianne P.; Dafer, Rima M.; Tavarez, Tachira; Pellack, Danielle R.; Garg, Rajeev; Osteraas, Nicholas D.; Vargas, Alejandro; John, Sayona; Da Silva, Ivan; Conners, James J. title: Acute Ischemic Stroke and COVID-19: Experience From a Comprehensive Stroke Center in Midwest US date: 2020-08-20 journal: Front Neurol DOI: 10.3389/fneur.2020.00910 sha: doc_id: 311942 cord_uid: oju4gosw file: cache/cord-311000-abntwzuy.json key: cord-311000-abntwzuy authors: Sommer, Adir C.; Blumenthal, Eytan Z. title: Telemedicine in ophthalmology in view of the emerging COVID-19 outbreak date: 2020-08-19 journal: Graefes Arch Clin Exp Ophthalmol DOI: 10.1007/s00417-020-04879-2 sha: doc_id: 311000 cord_uid: abntwzuy file: cache/cord-311418-7core0y3.json key: cord-311418-7core0y3 authors: Kutsenko, Oleksandra title: Guest Editorial: Radiology Nurses Can Raise the Impact on Promoting IR date: 2020-04-02 journal: J Radiol Nurs DOI: 10.1016/j.jradnu.2020.03.003 sha: doc_id: 311418 cord_uid: 7core0y3 file: cache/cord-311847-2czqs84q.json key: cord-311847-2czqs84q authors: Pennisi, Manuela; Lanza, Giuseppe; Falzone, Luca; Fisicaro, Francesco; Ferri, Raffaele; Bella, Rita title: SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms date: 2020-07-31 journal: Int J Mol Sci DOI: 10.3390/ijms21155475 sha: doc_id: 311847 cord_uid: 2czqs84q file: cache/cord-311816-j8c2lk7y.json key: cord-311816-j8c2lk7y authors: D’Elia, Emilia; Senni, Michele title: Coronavirus Disease 2019: Where are we and Where are we Going? Intersections Between Coronavirus Disease 2019 and the Heart date: 2020-06-29 journal: Card Fail Rev DOI: 10.15420/cfr.2020.11 sha: doc_id: 311816 cord_uid: j8c2lk7y file: cache/cord-312063-5c2w2ct1.json key: cord-312063-5c2w2ct1 authors: McCollum, Lauren; Karlawish, Jason title: Cognitive Impairment Evaluation and Management date: 2020-08-10 journal: Med Clin North Am DOI: 10.1016/j.mcna.2020.06.007 sha: doc_id: 312063 cord_uid: 5c2w2ct1 file: cache/cord-312065-nqy7m38f.json key: cord-312065-nqy7m38f authors: Peng, Philip W. H.; Wong, David T.; Bevan, David; Gardam, Michael title: Infection control and anesthesia: Lessons learned from the Toronto SARS outbreak date: 2003 journal: Can J Anaesth DOI: 10.1007/bf03018361 sha: doc_id: 312065 cord_uid: nqy7m38f file: cache/cord-312199-jy3izkou.json key: cord-312199-jy3izkou authors: Kraus, Kent R.; Buller, Leonard T.; Caccavallo, Peter; Ziemba-Davis, Mary; Meneghini, R. Michael title: Is There Benefit in Keeping Early Discharge Patients Overnight After Total Joint Arthroplasty? date: 2020-07-16 journal: J Arthroplasty DOI: 10.1016/j.arth.2020.07.021 sha: doc_id: 312199 cord_uid: jy3izkou file: cache/cord-312249-k7dp776s.json key: cord-312249-k7dp776s authors: Srinivasan, L.; Rishel, C. A.; Larson, B. J.; Yoo, J.; Shelton, N. title: Split ventilation with pressure regulators for patient-specific tidal volumes date: 2020-07-06 journal: nan DOI: 10.1101/2020.07.03.20145409 sha: doc_id: 312249 cord_uid: k7dp776s file: cache/cord-311838-ymn96yj4.json key: cord-311838-ymn96yj4 authors: LIU)刘茜玮(, Qianwei; ZHAO)赵国桢(, Guozhen; JI)嵇波(, Bo; LIU)刘翼天(, Yitian; ZHANG)张靖宇(, Jingyu; MOU)牟秋杰(, Qiujie; SHI)石天宇(, Tianyu title: Analysis of the Influence of the Psychology Changes of Fear Induced by the COVID-19 Epidemic on the Body date: 2020-07-15 journal: World J Acupunct Moxibustion DOI: 10.1016/j.wjam.2020.06.007 sha: doc_id: 311838 cord_uid: ymn96yj4 file: cache/cord-311957-3rmm1hfb.json key: cord-311957-3rmm1hfb authors: Faes, C.; Abrams, S.; Van Beckhoven, D.; Meyfroidt, G.; Vlieghe, E.; Hens, N. title: Time between Symptom Onset, Hospitalisation and Recovery or Death: a Statistical Analysis of Different Time-Delay Distributions in Belgian COVID-19 Patients date: 2020-07-21 journal: nan DOI: 10.1101/2020.07.18.20156307 sha: doc_id: 311957 cord_uid: 3rmm1hfb file: cache/cord-312313-guphuppy.json key: cord-312313-guphuppy authors: Patel, Zara M; Fernandez-Miranda, Juan; Hwang, Peter H; Nayak, Jayakar V; Dodd, Robert; Sajjadi, Hamed; Jackler, Robert K title: Letter: Precautions for Endoscopic Transnasal Skull Base Surgery During the COVID-19 Pandemic date: 2020-04-15 journal: Neurosurgery DOI: 10.1093/neuros/nyaa125 sha: doc_id: 312313 cord_uid: guphuppy file: cache/cord-312057-4zfaqkxm.json key: cord-312057-4zfaqkxm authors: Leppla, Idris E.; Gross, Marielle S. title: Optimizing Medication Treatment of Opioid Use Disorder During COVID-19 (SARS-CoV-2) date: 2020-05-14 journal: J Addict Med DOI: 10.1097/adm.0000000000000678 sha: doc_id: 312057 cord_uid: 4zfaqkxm file: cache/cord-312192-hxhohtmj.json key: cord-312192-hxhohtmj authors: Zhu, Lan; Gong, Nianqiao; Liu, Bin; Lu, Xia; Chen, Dong; Chen, Song; Shu, Hongge; Ma, Ke; Xu, Xizhen; Guo, Zhiliang; Lu, Enfeng; Chen, Dongrui; Ge, Qinggang; Cai, Junchao; Jiang, Jipin; Wei, Lai; Zhang, Weijie; Chen, Gang; Chen, Zhishui title: Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China date: 2020-04-18 journal: Eur Urol DOI: 10.1016/j.eururo.2020.03.039 sha: doc_id: 312192 cord_uid: hxhohtmj file: cache/cord-312012-6a7i72bk.json key: cord-312012-6a7i72bk authors: Scalea, Joseph R. title: The Distancing of Surgeon From Patient in the Era of COVID-19: Bring on the Innovation date: 2020-04-13 journal: Ann Surg DOI: 10.1097/sla.0000000000003962 sha: doc_id: 312012 cord_uid: 6a7i72bk file: cache/cord-312388-pc89ybxw.json key: cord-312388-pc89ybxw authors: Singhania, Namrata; Bansal, Saurabh; Nimmatoori, Divya P.; Ejaz, Abutaleb A.; McCullough, Peter A.; Singhania, Girish title: Current Overview on Hypercoagulability in COVID-19 date: 2020-08-04 journal: Am J Cardiovasc Drugs DOI: 10.1007/s40256-020-00431-z sha: doc_id: 312388 cord_uid: pc89ybxw file: cache/cord-312212-h5j4f0xq.json key: cord-312212-h5j4f0xq authors: Dooley, Anjali B.; Houssaye, Nadia de la; Baum, Neil title: Use of Telemedicine for Sexual Medicine Patients date: 2020-07-30 journal: Sex Med Rev DOI: 10.1016/j.sxmr.2020.06.001 sha: doc_id: 312212 cord_uid: h5j4f0xq file: cache/cord-312609-gv1khfmo.json key: cord-312609-gv1khfmo authors: Fatima, Nida; Saqqur, Maher; Qamar, Fatima; Shaukat, Samia; Shuaib, Ashfaq title: Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic date: 2020-08-06 journal: Neurol Sci DOI: 10.1007/s10072-020-04637-6 sha: doc_id: 312609 cord_uid: gv1khfmo file: cache/cord-312033-iarl77n0.json key: cord-312033-iarl77n0 authors: López Barreda, Rodrigo; Guerrero, Alonso; de la Cuadra, Juan Cristóbal; Scotoni, Manuela; Salas, Wilbaldo; Baraona, Fernando; Arancibia, Francisca; Uriarte, Polentzi title: Poverty, quality of life and psychological wellbeing in adults with congenital heart disease in Chile date: 2020-10-08 journal: PLoS One DOI: 10.1371/journal.pone.0240383 sha: doc_id: 312033 cord_uid: iarl77n0 file: cache/cord-312486-rumqopg0.json key: cord-312486-rumqopg0 authors: Jacob, Chaim Oscar title: On the genetics and immunopathogenesis of COVID-19 date: 2020-09-10 journal: Clin Immunol DOI: 10.1016/j.clim.2020.108591 sha: doc_id: 312486 cord_uid: rumqopg0 file: cache/cord-312467-kbhljong.json key: cord-312467-kbhljong authors: Boilève, Alice; Stoclin, Annabelle; Barlesi, Fabrice; Varin, Florent; Suria, Stéphanie; Rieutord, André; Blot, François; Netzer, Florence; Scotté, Florian title: COVID-19 management in a cancer center: the ICU storm date: 2020-07-31 journal: Support Care Cancer DOI: 10.1007/s00520-020-05658-9 sha: doc_id: 312467 cord_uid: kbhljong file: cache/cord-313028-0nhgxoim.json key: cord-313028-0nhgxoim authors: Huang, Chaolin; Wang, Yeming; Li, Xingwang; Ren, Lili; Zhao, Jianping; Hu, Yi; Zhang, Li; Fan, Guohui; Xu, Jiuyang; Gu, Xiaoying; Cheng, Zhenshun; Yu, Ting; Xia, Jiaan; Wei, Yuan; Wu, Wenjuan; Xie, Xuelei; Yin, Wen; Li, Hui; Liu, Min; Xiao, Yan; Gao, Hong; Guo, Li; Xie, Jungang; Wang, Guangfa; Jiang, Rongmeng; Gao, Zhancheng; Jin, Qi; Wang, Jianwei; Cao, Bin title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China date: 2020-01-24 journal: Lancet DOI: 10.1016/s0140-6736(20)30183-5 sha: doc_id: 313028 cord_uid: 0nhgxoim file: cache/cord-312572-i7r28wdc.json key: cord-312572-i7r28wdc authors: Sosnowski, Roman; Kamecki, Hubert; Joniau, Steven; Walz, Jochen; Dowling, John; Behrendt, Mark; Klaassen, Zachary; Palou, Joan; van Poppel, Hendrik title: Uro-oncology in the era of social distancing: the principles of patient-centered online consultations during the COVID-19 pandemic date: 2020-07-28 journal: Cent European J Urol DOI: 10.5173/ceju.2020.0171 sha: doc_id: 312572 cord_uid: i7r28wdc file: cache/cord-312677-rwznqiib.json key: cord-312677-rwznqiib authors: Razmi, Mahdieh; Hashemi, Farideh; Gheytanchi, Elmira; Dehghan, Masoumeh; Ghods, Roya; Madjd, Zahra title: Immunomodulatory-Based Therapy as a Potential Promising Treatment Strategy against Severe COVID-19 Patients: A Systematic Review date: 2020-08-29 journal: Int Immunopharmacol DOI: 10.1016/j.intimp.2020.106942 sha: doc_id: 312677 cord_uid: rwznqiib file: cache/cord-312209-3yi1w44v.json key: cord-312209-3yi1w44v authors: Bernstein, David N; Baumhauer, Judith F; Kang, James D; Makhni, Melvin C title: Transforming the Orthopaedic Patient Experience Through Telemedicine date: 2020-05-27 journal: J Patient Exp DOI: 10.1177/2374373520929449 sha: doc_id: 312209 cord_uid: 3yi1w44v file: cache/cord-312614-63qzissw.json key: cord-312614-63qzissw authors: Latham, Stephen R. title: Avoiding Ineffective End‐of‐Life Care: A Lesson from Triage? date: 2020-06-29 journal: Hastings Cent Rep DOI: 10.1002/hast.1141 sha: doc_id: 312614 cord_uid: 63qzissw file: cache/cord-312748-9v2bmbod.json key: cord-312748-9v2bmbod authors: Guo, Zhen; Sun, Lin; Li, Bailing; Tian, Rui; Zhang, Xiaolin; Zhang, Zhongwei; Clifford, Sean P.; Liu, Yuan; Huang, Jiapeng; Li, Xin title: Anticoagulation Management in Severe COVID-19 Patients on Extracorporeal Membrane Oxygenation date: 2020-09-04 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.08.067 sha: doc_id: 312748 cord_uid: 9v2bmbod file: cache/cord-312754-3yhxcfr2.json key: cord-312754-3yhxcfr2 authors: Allen, Bradley D.; Wong, Timothy C.; Bucciarelli-Ducci, Chiara; Bryant, Jennifer; Chen, Tiffany; Dall’Armellina, Erica; Finn, J. Paul; Fontana, Marianna; Francone, Marco; Han, Yuchi; Hays, Allison G.; Jacob, Ron; Lawton, Chris; Manning, Warren J.; Ordovas, Karen; Parwani, Purvi; Plein, Sven; Powell, Andrew J.; Raman, Subha V.; Salerno, Michael; Carr, James C. title: Society for Cardiovascular Magnetic Resonance (SCMR) guidance for re-activation of cardiovascular magnetic resonance practice after peak phase of the COVID-19 pandemic date: 2020-08-10 journal: J Cardiovasc Magn Reson DOI: 10.1186/s12968-020-00654-8 sha: doc_id: 312754 cord_uid: 3yhxcfr2 file: cache/cord-312795-0e4esl2o.json key: cord-312795-0e4esl2o authors: Puig-Domingo, M.; Marazuela, M.; Giustina, A. title: COVID-19 and endocrine diseases. A statement from the European Society of Endocrinology date: 2020-04-11 journal: Endocrine DOI: 10.1007/s12020-020-02294-5 sha: doc_id: 312795 cord_uid: 0e4esl2o file: cache/cord-312798-2cbgnv1h.json key: cord-312798-2cbgnv1h authors: Varma, Niraj; Marrouche, Nassir F.; Aguinaga, Luis; Albert, Christine M.; Arbelo, Elena; Choi, Jong-Il; Chung, Mina K.; Conte, Giulio; Dagher, Lilas; Epstein, Laurence M.; Ghanbari, Hamid; Han, Janet K.; Heidbuchel, Hein; Huang, He; Lakkireddy, Dhanunjaya R.; Ngarmukos, Tachapong; Russo, Andrea M.; Saad, Eduardo B.; Saenz Morales, Luis C.; Sandau, Kristin E.; Sridhar, Arun Raghav M.; Stecker, Eric C.; Varosy, Paul D. title: HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date: 2020-06-11 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2020.06.019 sha: doc_id: 312798 cord_uid: 2cbgnv1h file: cache/cord-312846-ef7m4875.json key: cord-312846-ef7m4875 authors: Nerina, Denaro; Anna Maria, Merlotti; Marco Carlo, Merlano; Russi, Elvio title: Coronavirus Disease 19 (COVID-19) during chemoradiation for locally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC) date: 2020-05-14 journal: Oral Oncol DOI: 10.1016/j.oraloncology.2020.104801 sha: doc_id: 312846 cord_uid: ef7m4875 file: cache/cord-312847-2cg3ylfl.json key: cord-312847-2cg3ylfl authors: Carter, Chris; Aedy, Helen; Notter, Joy title: COVID-19 Disease: assessment of a critically ill patient date: 2020-06-01 journal: nan DOI: 10.1016/j.intcar.2020.100001 sha: doc_id: 312847 cord_uid: 2cg3ylfl file: cache/cord-312918-iof45k1r.json key: cord-312918-iof45k1r authors: Ortolani, Claudio; Pastorello, Elide A. title: Hydroxychloroquine and dexamethasone in COVID-19: who won and who lost? date: 2020-09-09 journal: Clin Mol Allergy DOI: 10.1186/s12948-020-00132-7 sha: doc_id: 312918 cord_uid: iof45k1r file: cache/cord-313082-n3bo9jw1.json key: cord-313082-n3bo9jw1 authors: Tenenbein, Paul; Riazi, Sheila; Johnstone, Jennie; Keshavjee, Shaf; Karkouti, Keyvan title: The case for routine screening for SARS-CoV-2 before surgery date: 2020-06-03 journal: Can J Anaesth DOI: 10.1007/s12630-020-01730-4 sha: doc_id: 313082 cord_uid: n3bo9jw1 file: cache/cord-312632-g4250q6l.json key: cord-312632-g4250q6l authors: Cai, Xiaofang; Ma, Yaoling; Li, Songbo; Chen, Yan; Rong, Zhihui; Li, Wenbin title: Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children date: 2020-05-12 journal: Front Pediatr DOI: 10.3389/fped.2020.00258 sha: doc_id: 312632 cord_uid: g4250q6l file: cache/cord-313136-ab56mg6j.json key: cord-313136-ab56mg6j authors: Pavoni, Vittorio; Gianesello, Lara; Pazzi, Maddalena; Stera, Caterina; Meconi, Tommaso; Frigieri, Francesca Covani title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia date: 2020-05-11 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02130-7 sha: doc_id: 313136 cord_uid: ab56mg6j file: cache/cord-313294-ffgo56gl.json key: cord-313294-ffgo56gl authors: Bertsimas, D.; Borenstein, A.; Mingardi, L.; Nohadani, O.; Orfanoudaki, A.; Stellato, B.; Wiberg, H.; Sarin, P.; Varelmann, D.; Estrada, V.; Macaya, C.; Nunez Gil, I. title: Personalized Prescription of ACEI/ARBs for Hypertensive COVID-19 Patients date: 2020-11-04 journal: nan DOI: 10.1101/2020.10.30.20223594 sha: doc_id: 313294 cord_uid: ffgo56gl file: cache/cord-312684-3i2r2ahr.json key: cord-312684-3i2r2ahr authors: Iba, Toshiaki; Levy, Jerrold H.; Levi, Marcel; Thachil, Jecko title: Coagulopathy in COVID‐19 date: 2020-06-18 journal: J Thromb Haemost DOI: 10.1111/jth.14975 sha: doc_id: 312684 cord_uid: 3i2r2ahr file: cache/cord-313349-ikjivfce.json key: cord-313349-ikjivfce authors: Finsterer, Josef; Stollberger, Claudia title: Causes of hypogeusia/hyposmia in SARS‐CoV2 infected patients date: 2020-04-20 journal: J Med Virol DOI: 10.1002/jmv.25903 sha: doc_id: 313349 cord_uid: ikjivfce file: cache/cord-313353-uwwih8v3.json key: cord-313353-uwwih8v3 authors: Di Tano, Giuseppe; Moschini, Luigi; Loffi, Marco; Testa, Sophie; Danzi, Gian Battista title: Late Pulmonary Embolism after COVID-19 Pneumonia despite Adequate Rivaroxaban Treatment date: 2020-06-18 journal: Eur J Case Rep Intern Med DOI: 10.12890/2020_001790 sha: doc_id: 313353 cord_uid: uwwih8v3 file: cache/cord-313118-dv5xq2k4.json key: cord-313118-dv5xq2k4 authors: Davis, Eric M.; Ramani, Chintan; Quigg, Mark title: Neurologic Manifestations of Systemic Disease: Sleep Disorders date: 2020-08-06 journal: Curr Treat Options Neurol DOI: 10.1007/s11940-020-00639-z sha: doc_id: 313118 cord_uid: dv5xq2k4 file: cache/cord-313728-08kwkbmd.json key: cord-313728-08kwkbmd authors: Binda, Barbara; Picchi, Giovanna; Carucci, Anna Cecilia; Sinatti, Gaia; Di Norcia, Monica; Grimaldi, Alessandro; Lancione, Laura; Natili, Andrea; Chiappori, Davide; Montali, Filippo; Lupi, Diana; Martinez, Viviana; Panarese, Alessandra; D’Anselmi, Fabrizio; Pisani, Francesco title: Follow-up and Management of Kidney Transplant Recipients During the COVID-19 Lockdown: the experience of an Italian Transplant Center, Including Two Cases of COVID-19 Pneumonia date: 2020-06-28 journal: Transplant Proc DOI: 10.1016/j.transproceed.2020.06.026 sha: doc_id: 313728 cord_uid: 08kwkbmd file: cache/cord-313227-6zwkfzab.json key: cord-313227-6zwkfzab authors: Scala, Stefania; Pacelli, Roberto title: Fighting the Host Reaction to SARS-COv-2 in Critically Ill Patients: The Possible Contribution of Off-Label Drugs date: 2020-05-27 journal: Front Immunol DOI: 10.3389/fimmu.2020.01201 sha: doc_id: 313227 cord_uid: 6zwkfzab file: cache/cord-313239-0gl43af5.json key: cord-313239-0gl43af5 authors: Moreno, Courtney C.; Yee, Judy; Ahmed, Firas S.; Barish, Matthew A.; Brewington, Cecelia; Dachman, Abraham H.; Gollub, Marc J.; Kim, David H.; McFarland, Elizabeth; Pickhardt, Perry J.; Reddy, Syam; Zalis, Michael; Chang, Kevin J. title: CT colonography’s role in the COVID-19 pandemic: a safe(r), socially distanced total colon examination date: 2020-08-03 journal: Abdom Radiol (NY) DOI: 10.1007/s00261-020-02674-5 sha: doc_id: 313239 cord_uid: 0gl43af5 file: cache/cord-313468-lloh1b0y.json key: cord-313468-lloh1b0y authors: Fernández‐Aranda, Fernando; Munguía, Lucero; Mestre‐Bach, Gemma; Steward, Trevor; Etxandi, Mikel; Baenas, Isabel; Granero, Roser; Sánchez, Isabel; Ortega, Emilio; Andreu, Alba; Moize, Violeta L.; Fernández‐Real, Jose M; Tinahones, Francisco J.; Diegüez, Carlos; Frühbeck, Gema; Le Grange, Daniel; Tchanturia, Kate; Karwautz, Andreas; Zeiler, Michael; Favaro, Angela; Claes, Laurence; Luyckx, Koen; Shekriladze, Ia; Serrano‐Troncoso, Eduardo; Rangil, Teresa; Meler, Maria Eulalia Loran; Soriano‐Pacheco, Jose; Carceller‐Sindreu, Mar; Bujalance‐Arguijo, Sara; Lozano, Meritxell; Linares, Raquel; Gudiol, Carlota; Carratala, Jordi; Sanchez‐Gonzalez, Jessica; Machado, Paulo PP; Håkansson, Anders; Túry, Ferenc; Pászthy, Bea; Stein, Daniel; Papezová, Hana; Bax, Brigita; Borisenkov, Mikhail F.; Popov, Sergey V.; Kim, Youl‐Ri; Nakazato, Michiko; Godart, Nathalie; van Voren, Robert; Ilnytska, Tetiana; Chen, Jue; Rowlands, Katie; Treasure, Janet; Jiménez‐Murcia, Susana title: COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity—A collaborative international study date: 2020-09-20 journal: Eur Eat Disord Rev DOI: 10.1002/erv.2784 sha: doc_id: 313468 cord_uid: lloh1b0y file: cache/cord-313494-a4pms2ub.json key: cord-313494-a4pms2ub authors: Sampedro, Ana Diez; Gonzalez, Arturo; Delgado, Victor; Flowers, Monica; Maltseva, Tatayana; Olenick, Maria title: COVID-19 and Advanced Practice Registered Nurses (APRNs): Frontline update #1 date: 2020-06-18 journal: J Nurse Pract DOI: 10.1016/j.nurpra.2020.06.014 sha: doc_id: 313494 cord_uid: a4pms2ub file: cache/cord-313529-xm76ae08.json key: cord-313529-xm76ae08 authors: Liu, Wen-Kuan; Chen, De-Hui; Liu, Qian; Liang, Huan-Xi; Yang, Zi-Feng; Qin, Sheng; Zhou, Rong title: Detection of human bocavirus from children and adults with acute respiratory tract illness in Guangzhou, southern China date: 2011-12-14 journal: BMC Infect Dis DOI: 10.1186/1471-2334-11-345 sha: doc_id: 313529 cord_uid: xm76ae08 file: cache/cord-313628-6610z7xk.json key: cord-313628-6610z7xk authors: Igbinosa, Irogue; Miller, Sarah; Bianco, Katherine; Nelson, Joanna; Kappagoda, Shanthi; Blackburn, Brian G.; Grant, Philip; Subramanian, Aruna; Lyell, Deirdre; El-Sayed, Yasser; Aziz, Natali title: Use of Remdesivir for Pregnant Patients with Severe Novel 2019 Coronavirus Disease date: 2020-08-07 journal: Am J Obstet Gynecol DOI: 10.1016/j.ajog.2020.08.001 sha: doc_id: 313628 cord_uid: 6610z7xk file: cache/cord-313693-qmkrn7pr.json key: cord-313693-qmkrn7pr authors: Wong, Bonnie C. K.; Lee, Nelson; Li, Yuguo; Chan, Paul K. S.; Qiu, Hong; Luo, Zhiwen; Lai, Raymond W. M.; Ngai, Karry L. K.; Hui, David S. C.; Choi, K. W.; Yu, Ignatius T. S. title: Possible Role of Aerosol Transmission in a Hospital Outbreak of Influenza date: 2010-11-15 journal: Clin Infect Dis DOI: 10.1086/656743 sha: doc_id: 313693 cord_uid: qmkrn7pr file: cache/cord-313528-rp15vi1o.json key: cord-313528-rp15vi1o authors: Wallace, Douglas W.; Burleson, Samuel L.; Heimann, Matthew A.; Crosby, James C.; Swanson, Jonathan; Gibson, Courtney B.; Greene, Christopher title: An adapted emergency department triage algorithm for the COVID‐19 pandemic date: 2020-08-10 journal: J Am Coll Emerg Physicians Open DOI: 10.1002/emp2.12210 sha: doc_id: 313528 cord_uid: rp15vi1o file: cache/cord-313684-61hkogdh.json key: cord-313684-61hkogdh authors: Samaddar, Arghadip; Grover, Malika; Nag, Vijaya Lakshmi title: Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena date: 2020-09-17 journal: Front Pharmacol DOI: 10.3389/fphar.2020.585888 sha: doc_id: 313684 cord_uid: 61hkogdh file: cache/cord-313785-8tipkksu.json key: cord-313785-8tipkksu authors: d'Ettorre, Gabriella; Ceccarelli, Giancarlo; Marazzato, Massimiliano; Campagna, Giuseppe; Pinacchio, Claudia; Alessandri, Francesco; Ruberto, Franco; Rossi, Giacomo; Celani, Luigi; Scagnolari, Carolina; Mastropietro, Cristina; Trinchieri, Vito; Recchia, Gregorio Egidio; Mauro, Vera; Antonelli, Guido; Pugliese, Francesco; Mastroianni, Claudio Maria title: Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19 date: 2020-07-07 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00389 sha: doc_id: 313785 cord_uid: 8tipkksu file: cache/cord-313836-mcm0xmzw.json key: cord-313836-mcm0xmzw authors: Di Micco, Pierpaolo; Russo, Vincenzo; Lodigiani, Corrado title: Venous Thromboembolism and Its Association with COVID-19: Still an Open Debate date: 2020-09-27 journal: Medicina (Kaunas) DOI: 10.3390/medicina56100506 sha: doc_id: 313836 cord_uid: mcm0xmzw file: cache/cord-313894-stgx36h5.json key: cord-313894-stgx36h5 authors: Ürün, Yüksel; Hussain, Syed A.; Bakouny, Ziad; Castellano, Daniel; Kılıçkap, Saadettin; Morgan, Gilberto; Mckay, Rana R.; Pels, Kevin; Schmidt, Andrew; Doroshow, Deborah B.; Schütz, Fábio; Albiges, Laurence; Lopes, Gilberto; Catto, James W. F.; Peters, Solange; Choueiri, Toni K. title: Survey of the Impact of COVID-19 on Oncologists’ Decision Making in Cancer date: 2020-08-05 journal: JCO Glob Oncol DOI: 10.1200/go.20.00300 sha: doc_id: 313894 cord_uid: stgx36h5 file: cache/cord-313976-q5j5kr1v.json key: cord-313976-q5j5kr1v authors: Alaarag, Ahmed; Hassan, Timoor; Samir, Sameh; Naseem, Mohamed title: Clinical and angiographic characteristics of patients with STEMI and confirmed diagnosis of COVID-19: an experience of Tanta University Hospital date: 2020-10-06 journal: Egypt Heart J DOI: 10.1186/s43044-020-00103-y sha: doc_id: 313976 cord_uid: q5j5kr1v file: cache/cord-314088-ktj17dvq.json key: cord-314088-ktj17dvq authors: Mancini, Francesca; van Halteren, Angelika D.; Carta, Tania; Thomas, Sue; Bloem, Bastiaan R.; Darweesh, Sirwan K.L. title: Personalized care management for persons with Parkinson's disease: A telenursing solution date: 2020-08-19 journal: Clin Park Relat Disord DOI: 10.1016/j.prdoa.2020.100070 sha: doc_id: 314088 cord_uid: ktj17dvq file: cache/cord-314218-6znw9zcz.json key: cord-314218-6znw9zcz authors: Baron, D. M.; Franchini, M.; Goobie, S. M.; Javidroozi, M.; Klein, A. A.; Lasocki, S.; Liumbruno, G. M.; Muñoz, M.; Shander, A.; Spahn, D. R.; Zacharowski, K.; Meybohm, P. title: Patient blood management during the COVID–19 pandemic: a narrative review date: 2020-05-06 journal: Anaesthesia DOI: 10.1111/anae.15095 sha: doc_id: 314218 cord_uid: 6znw9zcz file: cache/cord-313860-mzs3ya0s.json key: cord-313860-mzs3ya0s authors: Giulietti, Federico; Filipponi, Andrea; Rosettani, Giulia; Giordano, Piero; Iacoacci, Corrado; Spannella, Francesco; Sarzani, Riccardo title: Pharmacological Approach to Smoking Cessation: An Updated Review for Daily Clinical Practice date: 2020-06-23 journal: High Blood Press Cardiovasc Prev DOI: 10.1007/s40292-020-00396-9 sha: doc_id: 313860 cord_uid: mzs3ya0s file: cache/cord-313989-bc7q8swu.json key: cord-313989-bc7q8swu authors: Nicholls, Stephen J.; Nelson, Mark; Astley, Carolyn; Briffa, Tom; Brown, Alex; Clark, Robyn; Colquhoun, David; Gallagher, Robyn; Hare, David L.; Inglis, Sally; Jelinek, Michael; O’Neil, Adrienne; Tirimacco, Rosy; Vale, Margarite; Redfern, Julie title: Optimising Secondary Prevention and Cardiac Rehabilitation for Atherosclerotic Cardiovascular Disease During the COVID-19 Pandemic: A Position Statement from the Cardiac Society of Australia and New Zealand (CSANZ) # date: 2020-04-30 journal: Heart Lung Circ DOI: 10.1016/j.hlc.2020.04.007 sha: doc_id: 313989 cord_uid: bc7q8swu file: cache/cord-314070-8qz23nn4.json key: cord-314070-8qz23nn4 authors: Gubbi, Sriram; Nazari, Matthew A; Taieb, David; Klubo-Gwiezdzinska, Joanna; Pacak, Karel title: Catecholamine physiology and its implications in patients with COVID-19 date: 2020-10-28 journal: Lancet Diabetes Endocrinol DOI: 10.1016/s2213-8587(20)30342-9 sha: doc_id: 314070 cord_uid: 8qz23nn4 file: cache/cord-314152-wd153s1g.json key: cord-314152-wd153s1g authors: Noor, Farha Musharrat; Islam, Md. Momin title: Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis date: 2020-09-12 journal: J Community Health DOI: 10.1007/s10900-020-00920-x sha: doc_id: 314152 cord_uid: wd153s1g file: cache/cord-314171-431buxxr.json key: cord-314171-431buxxr authors: Dariya, Begum; Nagaraju, Ganji Purnchandra title: Understanding novel COVID-19: its impact on organ failure and risk assessment for diabetic and cancer patients date: 2020-05-06 journal: Cytokine Growth Factor Rev DOI: 10.1016/j.cytogfr.2020.05.001 sha: doc_id: 314171 cord_uid: 431buxxr file: cache/cord-314378-cs9ggqwk.json key: cord-314378-cs9ggqwk authors: Singh, Prateush; Ponniah, Allan; Nikkhah, Dariush; Mosahebi, Afshin title: The Effects of a Novel Global Pandemic (COVID-19) on a Plastic Surgery Department date: 2020-04-29 journal: Aesthet Surg J DOI: 10.1093/asj/sjaa074 sha: doc_id: 314378 cord_uid: cs9ggqwk file: cache/cord-314280-kf2bo06e.json key: cord-314280-kf2bo06e authors: Brissot, Eolia; Labopin, Myriam; Baron, Frédéric; Bazarbachi, Ali; Bug, Gesine; Ciceri, Fabio; Esteve, Jordi; Giebel, Sebastian; Gilleece, Maria H.; Gorin, Norbert-Claude; Lanza, Francesco; Peric, Zinaida; Ruggeri, Annalisa; Sanz, Jaime; Savani, Bipin N.; Schmid, Christoph; Shouval, Roni; Spyridonidis, Alexandros; Versluis, Jurjen; Nagler, Arnon; Mohty, Mohamad title: Management of patients with acute leukemia during the COVID-19 outbreak: practical guidelines from the acute leukemia working party of the European Society for Blood and Marrow Transplantation date: 2020-06-11 journal: Bone Marrow Transplant DOI: 10.1038/s41409-020-0970-x sha: doc_id: 314280 cord_uid: kf2bo06e file: cache/cord-314649-1y3ocvz1.json key: cord-314649-1y3ocvz1 authors: Franks, Caroline E; Scott, Mitchell G; Farnsworth, Christopher W title: Elevated Cardiac Troponin I Is Associated with Poor Outcomes in COVID-19 Patients at an Academic Medical Center in Midwestern USA date: 2020-06-02 journal: J Appl Lab Med DOI: 10.1093/jalm/jfaa092 sha: doc_id: 314649 cord_uid: 1y3ocvz1 file: cache/cord-315056-ohyb6oa0.json key: cord-315056-ohyb6oa0 authors: Xu, Juanjuan; Yin, Zhengrong; Liu, Yu; Wang, Sufei; Duan, Limin; An, Yi; Fan, Jinshuo; Liao, Tingting; Jin, Yang; Chen, Jianguo title: Clinical characteristics and outcomes of severe or critical COVID-19 patients presenting no respiratory symptoms or fever at onset date: 2020-10-29 journal: Engineering (Beijing) DOI: 10.1016/j.eng.2020.09.009 sha: doc_id: 315056 cord_uid: ohyb6oa0 file: cache/cord-314537-8a1vqale.json key: cord-314537-8a1vqale authors: Guo, Fuzheng; Du, Zhe; Wang, Tianbing title: An effective screening and management process in the outpatient clinic for patients requiring hospitalization during the COVID‐19 pandemic date: 2020-04-21 journal: J Med Virol DOI: 10.1002/jmv.25916 sha: doc_id: 314537 cord_uid: 8a1vqale file: cache/cord-315311-azamwuzl.json key: cord-315311-azamwuzl authors: Grattagliano, Ignazio; Rossi, Alessandro; Cricelli, Iacopo; Cricelli, Claudio title: The changing face of family medicine in the covid and post‐covid era date: 2020-06-07 journal: Eur J Clin Invest DOI: 10.1111/eci.13303 sha: doc_id: 315311 cord_uid: azamwuzl file: cache/cord-313474-1gux1gsi.json key: cord-313474-1gux1gsi authors: nan title: Physicians Abstracts date: 2015-03-20 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2015.27 sha: doc_id: 313474 cord_uid: 1gux1gsi file: cache/cord-314694-g0pes5o3.json key: cord-314694-g0pes5o3 authors: Cortiula, F.; Pettke, A.; Bartoletti, M.; Puglisi, F.; Helleday, T. title: Managing COVID-19 in the oncology clinic and avoiding the distraction effect date: 2020-03-19 journal: Ann Oncol DOI: 10.1016/j.annonc.2020.03.286 sha: doc_id: 314694 cord_uid: g0pes5o3 file: cache/cord-315116-u7btx7nt.json key: cord-315116-u7btx7nt authors: Cabrera-Tasayco, Fiorella del Pilar; Rivera-Carhuavilca, Juana Mercedes; Atoche-Socola, Katherine Joselyn; Peña-Soto, Claudio; Arriola-Guillén, Luis Ernesto title: Biosafety Measures at the Dental Office After the Appearance of COVID-19: A Systematic Review date: 2020-07-27 journal: Disaster medicine and public health preparedness DOI: 10.1017/dmp.2020.269 sha: doc_id: 315116 cord_uid: u7btx7nt file: cache/cord-315249-yclnl87n.json key: cord-315249-yclnl87n authors: Read, R. C. title: Infection in acute exacerbations of chronic bronchitis: a clinical perspective date: 1999-12-31 journal: Respiratory Medicine DOI: 10.1016/s0954-6111(99)90048-3 sha: doc_id: 315249 cord_uid: yclnl87n file: cache/cord-314826-usfvulc2.json key: cord-314826-usfvulc2 authors: Sharifipour, Ehsan; Shams, Saeed; Esmkhani, Mohammad; Khodadadi, Javad; Fotouhi-Ardakani, Reza; Koohpaei, Alireza; Doosti, Zahra; EJ Golzari, Samad title: Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU date: 2020-09-01 journal: BMC Infect Dis DOI: 10.1186/s12879-020-05374-z sha: doc_id: 314826 cord_uid: usfvulc2 file: cache/cord-315297-o8mwmjql.json key: cord-315297-o8mwmjql authors: Stephens, Elizabeth H.; Dearani, Joseph A.; Guleserian, Kristine J.; Overman, David M.; Tweddell, James S.; Backer, Carl L.; Romano, Jennifer C.; Bacha, Emile title: COVID-19: Crisis Management in Congenital Heart Surgery date: 2020-04-14 journal: Ann Thorac Surg DOI: 10.1016/j.athoracsur.2020.04.001 sha: doc_id: 315297 cord_uid: o8mwmjql file: cache/cord-314349-rhm1ii3d.json key: cord-314349-rhm1ii3d authors: Kraft, Miquel; Pellino, Gianluca; Jofra, Mariona; Sorribas, Maria; Solís-Peña, Alejandro; Biondo, Sebastiano; Espín-Basany, Eloy title: Incidence, features, outcome and impact on health system of de-novo abdominal surgical diseases in patients admitted with COVID-19 date: 2020-08-28 journal: Surgeon DOI: 10.1016/j.surge.2020.08.006 sha: doc_id: 314349 cord_uid: rhm1ii3d file: cache/cord-315397-cm3mc7we.json key: cord-315397-cm3mc7we authors: Park, H. C.; Kim, D. H.; Cho, A.; Kim, J.; Yun, K.-s.; Lee, Y.-K. title: Clinical Outcome of Asymptomatic COVID-19 Infection Among a Large Nationwide Cohort of 5,621 Hospitalized Patients in Korea date: 2020-10-27 journal: nan DOI: 10.1101/2020.10.25.20218982 sha: doc_id: 315397 cord_uid: cm3mc7we file: cache/cord-315181-emf4i6ir.json key: cord-315181-emf4i6ir authors: Ryoo, Nayoung; Pyun, Jung-Min; Baek, Min Jae; Suh, Jeewon; Kang, Min Ju; Wang, Min Jeong; Youn, Young Chul; Yang, Dong Won; Kim, Seong Yoon; Park, Young Ho; Kim, SangYun title: Coping with Dementia in the Middle of the COVID-19 Pandemic date: 2020-10-27 journal: J Korean Med Sci DOI: 10.3346/jkms.2020.35.e383 sha: doc_id: 315181 cord_uid: emf4i6ir file: cache/cord-315188-a9pvugjt.json key: cord-315188-a9pvugjt authors: Choi, Min Hyuk; Ahn, Hyunmin; Ryu, Han Seok; Kim, Byung-Jun; Jang, Joonyong; Jung, Moonki; Kim, Jinuoung; Jeong, Seok Hoon title: Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea date: 2020-06-23 journal: J Clin Med DOI: 10.3390/jcm9061959 sha: doc_id: 315188 cord_uid: a9pvugjt file: cache/cord-315195-m2xqlct8.json key: cord-315195-m2xqlct8 authors: Alfano, Gaetano; Fontana, Francesco; Ferrari, Annachiara; Guaraldi, Giovanni; Mussini, Cristina; Magistroni, Riccardo; Cappelli, Gianni title: Peritoneal dialysis in the time of coronavirus disease 2019 date: 2020-07-16 journal: Clin Kidney J DOI: 10.1093/ckj/sfaa093 sha: doc_id: 315195 cord_uid: m2xqlct8 file: cache/cord-315569-e56c5g8h.json key: cord-315569-e56c5g8h authors: Aminian, Ali; Kermansaravi, Mohammad; Azizi, Shahriar; Alibeigi, Peyman; Safamanesh, Sina; Mousavimaleki, Ali; Rezaei, Mohammad Taghi; Faridi, Maziar; Mokhber, Somayeh; Pazouki, Abdolreza; Safari, Saeed title: Bariatric Surgical Practice During the Initial Phase of COVID-19 Outbreak date: 2020-04-20 journal: Obes Surg DOI: 10.1007/s11695-020-04617-x sha: doc_id: 315569 cord_uid: e56c5g8h file: cache/cord-315486-pjb5v1tc.json key: cord-315486-pjb5v1tc authors: Wu, Xiaojun; Wang, Tong; Zhou, Yilu; Liu, Xiaofan; Zhou, Hong; Lu, Yang; Tan, Weijun; Yuan, Mingli; Ding, Xuhong; Zou, Jinjing; Li, Ruiyun; Liu, Hailing; Ewing, Rob M.; Hu, Yi; Nie, Hanxiang; Wang, Yihua title: Different Laboratory Abnormalities in COVID-19 Patients with Hypertension or Diabetes date: 2020-09-30 journal: Virol Sin DOI: 10.1007/s12250-020-00296-1 sha: doc_id: 315486 cord_uid: pjb5v1tc file: cache/cord-314106-r3axl3w1.json key: cord-314106-r3axl3w1 authors: Porembskaya, Olga; Toropova, Yana; Tomson, Vladimir; Lobastov, Kirill; Laberko, Leonid; Kravchuk, Viacheslav; Saiganov, Sergey; Brill, Alexander title: Pulmonary Artery Thrombosis: A Diagnosis That Strives for Its Independence date: 2020-07-18 journal: Int J Mol Sci DOI: 10.3390/ijms21145086 sha: doc_id: 314106 cord_uid: r3axl3w1 file: cache/cord-315574-jq1p5t8w.json key: cord-315574-jq1p5t8w authors: Copland, Michael; Hemmett, Juliya; MacRae, Jennifer M.; McCormick, Brendan; McCormick, Michael; Qirjazi, Elena; Singh, Rajinder S.; Zimmerman, Deborah title: Canadian Society of Nephrology COVID-19 Rapid Response Team Home Dialysis Recommendations date: 2020-05-29 journal: Can J Kidney Health Dis DOI: 10.1177/2054358120928153 sha: doc_id: 315574 cord_uid: jq1p5t8w file: cache/cord-314449-ukqux772.json key: cord-314449-ukqux772 authors: Curtis, L.T. title: Prevention of hospital-acquired infections: review of non-pharmacological interventions date: 2008-06-02 journal: J Hosp Infect DOI: 10.1016/j.jhin.2008.03.018 sha: doc_id: 314449 cord_uid: ukqux772 file: cache/cord-315970-m5o962yw.json key: cord-315970-m5o962yw authors: Di Ciaula, Agostino; Palmieri, Vincenzo O.; Migliore, Giovanni; Portincasa, Piero title: COVID‐19, internists and resilience: the north‐south Italy outbreak. date: 2020-06-01 journal: Eur J Clin Invest DOI: 10.1111/eci.13299 sha: doc_id: 315970 cord_uid: m5o962yw file: cache/cord-315149-71bmj5il.json key: cord-315149-71bmj5il authors: Caballero Bermejo, Antonio F.; Ruiz-Antorán, Belén; Fernández Cruz, Ana; Diago Sempere, Elena; Callejas Díaz, Alejandro; Múñez Rubio, Elena; Avendaño-Solá, Cristina; Ramos Martínez, Antonio; Sancho López, Aránzazu title: Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial date: 2020-09-16 journal: Trials DOI: 10.1186/s13063-020-04633-3 sha: doc_id: 315149 cord_uid: 71bmj5il file: cache/cord-315490-xs5v3uc3.json key: cord-315490-xs5v3uc3 authors: Kessler, Remi A.; Zimering, Jeffrey; Gilligan, Jeffrey; Rothrock, Robert; McNeill, Ian; Shrivastava, Raj K.; Caridi, John; Bederson, Joshua; Hadjipanayis, Constantinos G. title: Neurosurgical management of brain and spine tumors in the COVID-19 era: an institutional experience from the epicenter of the pandemic date: 2020-05-05 journal: J Neurooncol DOI: 10.1007/s11060-020-03523-7 sha: doc_id: 315490 cord_uid: xs5v3uc3 file: cache/cord-315696-43wmazxa.json key: cord-315696-43wmazxa authors: Marinaki, Smaragdi; Tsiakas, Stathis; Korogiannou, Maria; Grigorakos, Konstantinos; Papalois, Vassilios; Boletis, Ioannis title: A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts date: 2020-09-16 journal: J Clin Med DOI: 10.3390/jcm9092986 sha: doc_id: 315696 cord_uid: 43wmazxa file: cache/cord-315834-ashjw2xs.json key: cord-315834-ashjw2xs authors: Guo, Lingxi; Wei, Dong; Zhang, Xinxin; Wu, Yurong; Li, Qingyun; Zhou, Min; Qu, Jieming title: Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score date: 2019-12-03 journal: Front Microbiol DOI: 10.3389/fmicb.2019.02752 sha: doc_id: 315834 cord_uid: ashjw2xs file: cache/cord-315424-i3nnennw.json key: cord-315424-i3nnennw authors: Willer, Brittany L.; Thung, Arlyne K.; Corridore, Marco; D’Mello, Ajay J.; Schloss, Brian S.; Malhotra, Prashant S.; Walz, Patrick C.; Elmaraghy, Charles A.; Tobias, Joseph D.; Jatana, Kris R.; Raman, Vidya T. title: The otolaryngologist’s and anesthesiologist’s collaborative role in a pandemic: a large quaternary pediatric center’s experience with COVID-19 preparation and simulation date: 2020-06-10 journal: Int J Pediatr Otorhinolaryngol DOI: 10.1016/j.ijporl.2020.110174 sha: doc_id: 315424 cord_uid: i3nnennw file: cache/cord-315871-anguylf1.json key: cord-315871-anguylf1 authors: Aschendorff, A.; Arndt, S.; Kröger, S.; Wesarg, T.; Ketterer, M. C.; Kirchem, P.; Pixner, S.; Hassepaß, F.; Beck, R. title: Quality of cochlear implant rehabilitation under COVID-19 conditions date: 2020-10-09 journal: HNO DOI: 10.1007/s00106-020-00923-z sha: doc_id: 315871 cord_uid: anguylf1 file: cache/cord-315157-2p45frlk.json key: cord-315157-2p45frlk authors: Donell, Simon T.; Thaler, Martin; Budhiparama, Nicolaas C.; Buttaro, Martin A.; Chen, Antonia F.; Diaz-Ledezma, Claudio; Gomberg, Bruce; Hirschmann, Michael T.; Karachalios, Theofilos; Karpukhin, Alexey; Sandiford, Nemandra Amir; Shao, Hongyi; Tandogan, Reha; Violante, Bruno; Zagra, Luigi; Kort, Nanne P. title: Preparation for the next COVID-19 wave: The European Hip Society and European Knee Associates recommendations date: 2020-08-17 journal: Knee Surg Sports Traumatol Arthrosc DOI: 10.1007/s00167-020-06213-z sha: doc_id: 315157 cord_uid: 2p45frlk file: cache/cord-316003-xt59voyt.json key: cord-316003-xt59voyt authors: Say, Daphne S.; de Lorimier, Arthur; Lammers, Cathleen R.; Natale, JoAnne; Lakshminrusimha, Satyan; Wiedeman, Jean; Partridge, Elizabeth title: Risk Stratification and Personal Protective Equipment Use in Pediatric Endoscopy During the Coronavirus Disease 2019 Outbreak: A Single-center Protocol date: 2020-03-31 journal: J Pediatr Gastroenterol Nutr DOI: 10.1097/mpg.0000000000002731 sha: doc_id: 316003 cord_uid: xt59voyt file: cache/cord-316067-mlcczr8c.json key: cord-316067-mlcczr8c authors: Ng, Jia H.; Hirsch, Jamie S.; Wanchoo, Rimda; Sachdeva, Mala; Sakhiya, Vipulbhai; Hong, Susana; Jhaveri, Kenar D.; Fishbane, Steven title: Outcomes of patients with end-stage kidney disease hospitalized with COVID-19 date: 2020-08-15 journal: Kidney Int DOI: 10.1016/j.kint.2020.07.030 sha: doc_id: 316067 cord_uid: mlcczr8c file: cache/cord-316170-ihh0pxov.json key: cord-316170-ihh0pxov authors: Chang, De; Mo, Guoxin; Yuan, Xin; Tao, Yi; Peng, Xiaohua; Wang, Fu-Sheng; Xie, Lixin; Sharma, Lokesh; Dela Cruz, Charles S.; Qin, Enqiang title: Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection date: 2020-05-01 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202003-0524le sha: doc_id: 316170 cord_uid: ihh0pxov file: cache/cord-316135-kevyw19w.json key: cord-316135-kevyw19w authors: Nikoupour, Hamed; Kazemi, Kourosh; Arasteh, Peyman; Ghazimoghadam, Saba; Eghlimi, Hesameddin; Dara, Naghi; Gholami, Siavash; Nikeghbalian, Saman title: Pediatric liver transplantation and COVID-19: a case report date: 2020-10-06 journal: BMC Surg DOI: 10.1186/s12893-020-00878-6 sha: doc_id: 316135 cord_uid: kevyw19w file: cache/cord-315730-fzgxuak7.json key: cord-315730-fzgxuak7 authors: Penman, Sophie L.; Kiy, Robyn T.; Jensen, Rebecca L.; Beoku‐Betts, Christopher; Alfirevic, Ana; Back, David; Khoo, Saye H.; Owen, Andrew; Pirmohamed, Munir; Park, B. Kevin; Meng, Xiaoli; Goldring, Christopher E.; Chadwick, Amy E. title: Safety perspectives on presently considered drugs for the treatment of COVID‐19 date: 2020-07-17 journal: Br J Pharmacol DOI: 10.1111/bph.15204 sha: doc_id: 315730 cord_uid: fzgxuak7 file: cache/cord-316083-f1h2j6jx.json key: cord-316083-f1h2j6jx authors: Alamri, Ahmad; Oriez, Constance; Bouilloud, Florence; Dupuy, Olivier; Hamou, Adrien Ben title: nan date: 2020-05-21 journal: Presse Med DOI: 10.1016/j.lpm.2020.104027 sha: doc_id: 316083 cord_uid: f1h2j6jx file: cache/cord-316137-6zdxfv8v.json key: cord-316137-6zdxfv8v authors: Wang, Yuanyuan; Liu, Yuntao; Lv, Qingquan; Zheng, Danwen; Zhou, Li; Ouyang, Wenwei; Ding, Banghan; Zou, Xu; Yan, Fang; Liu, Bo; Chen, Jun; Liu, Tianzhu; Fu, Chicheng; Fang, Qu; Wang, Yi; Li, Fang; Chen, Ailan; Lundborg, Cecilia Stålsby; Guo, Jianwen; Wen, Zehuai; Zhang, Zhongde title: Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching date: 2020-11-05 journal: Phytomedicine DOI: 10.1016/j.phymed.2020.153404 sha: doc_id: 316137 cord_uid: 6zdxfv8v file: cache/cord-316029-z708c3ex.json key: cord-316029-z708c3ex authors: Brunsdon, Priya; Saluja, Bhawana; Sahajwalla, Chandrahas title: Clinical Pharmacology Considerations for Developing Small‐Molecule Treatments for COVID‐19 date: 2020-07-12 journal: J Clin Pharmacol DOI: 10.1002/jcph.1697 sha: doc_id: 316029 cord_uid: z708c3ex file: cache/cord-316306-vfez5k02.json key: cord-316306-vfez5k02 authors: Bini, Stefano A.; Schilling, Peter L.; Patel, Shaun P.; Kalore, Niraj V.; Ast, Michael; Maratt, Joseph; Schuett, Dustin; Lawrie, Charles M.; Chung, Christopher; Steele, G. Daxton title: Digital Orthopaedics. A Glimpse into the Future in The Midst of a Pandemic date: 2020-04-22 journal: J Arthroplasty DOI: 10.1016/j.arth.2020.04.048 sha: doc_id: 316306 cord_uid: vfez5k02 file: cache/cord-316432-xemz7zn9.json key: cord-316432-xemz7zn9 authors: Talaie, Haleh; Hosseini, Sayed Masoud; Nazari, Maryam; Fakhri, Yadollah; Mousavizadeh, Atieh; Vatanpour, Hossein; Firoozfar, Ali title: Is there any potential management against COVID-19? A systematic review and meta-analysis date: 2020-08-18 journal: Daru DOI: 10.1007/s40199-020-00367-4 sha: doc_id: 316432 cord_uid: xemz7zn9 file: cache/cord-316728-vyfkmniu.json key: cord-316728-vyfkmniu authors: Benyounes, Nadia; Van Der Vynckt, Clélie; Tibi, Séverine; Iglesias, Alexandra; Salomon, Laurence; Gout, Olivier; Tibi, Thierry title: Echocardiography in Confirmed and Highly Suspected Symptomatic COVID-19 Patients and Its Impact on Treatment Change date: 2020-09-16 journal: Cardiol Res Pract DOI: 10.1155/2020/4348598 sha: doc_id: 316728 cord_uid: vyfkmniu file: cache/cord-316095-jzyb4jn5.json key: cord-316095-jzyb4jn5 authors: Falahchai, Mehran; Babaee Hemmati, Yasamin; Hasanzade, Mahya title: Dental care management during the COVID‐19 outbreak date: 2020-09-19 journal: Spec Care Dentist DOI: 10.1111/scd.12523 sha: doc_id: 316095 cord_uid: jzyb4jn5 file: cache/cord-316370-t802kjpk.json key: cord-316370-t802kjpk authors: Szperka, Christina L.; Ailani, Jessica; Barmherzig, Rebecca; Klein, Brad C.; Minen, Mia T.; Halker Singh, Rashmi B.; Shapiro, Robert E. title: Migraine Care in the Era of COVID‐19: Clinical Pearls and Plea to Insurers date: 2020-04-03 journal: Headache DOI: 10.1111/head.13810 sha: doc_id: 316370 cord_uid: t802kjpk file: cache/cord-316118-ph582weg.json key: cord-316118-ph582weg authors: Frajkova, Zofia; Tedla, Miroslav; Tedlova, Eva; Suchankova, Magda; Geneid, Ahmed title: Postintubation Dysphagia During COVID-19 Outbreak-Contemporary Review date: 2020-05-28 journal: Dysphagia DOI: 10.1007/s00455-020-10139-6 sha: doc_id: 316118 cord_uid: ph582weg file: cache/cord-316376-76beuk0c.json key: cord-316376-76beuk0c authors: Medeiros, Augusto Kreling; Barbisan, Cinthia Callegari; Cruz, Italo Ribeiro; de Araújo, Eduardo Medeiros; Libânio, Bruna Brandão; Albuquerque, Kamila Seidel; Torres, Ulysses S. title: Higher frequency of hepatic steatosis at CT among COVID-19-positive patients date: 2020-07-18 journal: Abdom Radiol (NY) DOI: 10.1007/s00261-020-02648-7 sha: doc_id: 316376 cord_uid: 76beuk0c file: cache/cord-316666-qif1k62t.json key: cord-316666-qif1k62t authors: Ghati, Nirmal; Roy, Ambuj; Bhatnagar, Sushma; Bhati, Sumit; Bhushan, Sudha; Mahendran, Manjit; Thakur, Abhishek; Tiwari, Pawan; Dwivedi, Tanima; Mani, Kalaivani; Gupta, Ritu; Mohan, Anant; Garg, Rakesh; Saxena, Anita; Guleria, Randeep; Deepti, Siddharthan title: Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial date: 2020-10-30 journal: Trials DOI: 10.1186/s13063-020-04840-y sha: doc_id: 316666 cord_uid: qif1k62t file: cache/cord-316673-ffkh13xm.json key: cord-316673-ffkh13xm authors: Andina, David; Noguera‐Morel, Lucero; Bascuas‐Arribas, Marta; Gaitero‐Tristán, Jara; Alonso‐Cadenas, José Antonio; Escalada‐Pellitero, Silvia; Hernández‐Martín, Ángela; de la Torre‐Espi, Mercedes; Colmenero, Isabel; Torrelo, Antonio title: Chilblains in children in the setting of COVID‐19 pandemic date: 2020-05-22 journal: Pediatr Dermatol DOI: 10.1111/pde.14215 sha: doc_id: 316673 cord_uid: ffkh13xm file: cache/cord-316117-o29773cz.json key: cord-316117-o29773cz authors: Menzella, Francesco; Biava, Mirella; Barbieri, Chiara; Livrieri, Francesco; Facciolongo, Nicola title: Pharmacologicaltreatment of COVID-19: lights and shadows date: 2020-05-19 journal: Drugs Context DOI: 10.7573/dic.2020-4-6 sha: doc_id: 316117 cord_uid: o29773cz file: cache/cord-316845-k9zvsfvj.json key: cord-316845-k9zvsfvj authors: Robertson, Mary M.; Eapen, Valsamma; Rizzo, Renata; Stern, Jeremy S.; Hartmann, Andreas title: Gilles de la Tourette Syndrome: advice in the times of COVID-19 date: 2020-04-28 journal: F1000Res DOI: 10.12688/f1000research.23275.2 sha: doc_id: 316845 cord_uid: k9zvsfvj file: cache/cord-316572-7ei96rrn.json key: cord-316572-7ei96rrn authors: Touska, P; Oikonomou, G; Ngu, R; Chandra, A; Malhotra, A; Fry, A; Oakley, R; Arora, A; Jeannon, J-P; Simo, R title: The role of transoral fine needle aspiration in expediting diagnosis and reducing risk in head and neck cancer patients in the coronavirus disease 2019 (COVID-19) era: a single-institution experience date: 2020-09-02 journal: The Journal of laryngology and otology DOI: 10.1017/s0022215120001929 sha: doc_id: 316572 cord_uid: 7ei96rrn file: cache/cord-316647-jj8anf5g.json key: cord-316647-jj8anf5g authors: Shang, You; Pan, Chun; Yang, Xianghong; Zhong, Ming; Shang, Xiuling; Wu, Zhixiong; Yu, Zhui; Zhang, Wei; Zhong, Qiang; Zheng, Xia; Sang, Ling; Jiang, Li; Zhang, Jiancheng; Xiong, Wei; Liu, Jiao; Chen, Dechang title: Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China date: 2020-06-06 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00689-1 sha: doc_id: 316647 cord_uid: jj8anf5g file: cache/cord-316522-fbw9x3ik.json key: cord-316522-fbw9x3ik authors: Reiss, Allison B.; De Leon, Joshua; Dapkins, Isaac P.; Shahin, George; Peltier, Morgan R.; Goldberg, Eric R. title: A Telemedicine Approach to Covid-19 Assessment and Triage date: 2020-09-10 journal: Medicina (Kaunas) DOI: 10.3390/medicina56090461 sha: doc_id: 316522 cord_uid: fbw9x3ik file: cache/cord-316835-qf0c91vr.json key: cord-316835-qf0c91vr authors: McLeod, Jacob M.; Ng, Alan; Kruse, Dustin L.; Stone, Paul A. title: Nontraumatic Osteonecrosis of the Distal Tibia: A Case Presentation and Review of the Literature date: 2016-08-18 journal: J Foot Ankle Surg DOI: 10.1053/j.jfas.2016.04.001 sha: doc_id: 316835 cord_uid: qf0c91vr file: cache/cord-316987-3nhqx2qn.json key: cord-316987-3nhqx2qn authors: London, Viktoriya; McLaren, Rodney; Stein, Janet; Atallah, Fouad; Fisher, Nelli; Haberman, Shoshana; McCalla, Sandra; Minkoff, Howard title: Caring for Pregnant Patients with COVID-19: Practical Tips Getting from Policy to Practice date: 2020-05-07 journal: Am J Perinatol DOI: 10.1055/s-0040-1710539 sha: doc_id: 316987 cord_uid: 3nhqx2qn file: cache/cord-316873-2gwl9m94.json key: cord-316873-2gwl9m94 authors: Crowley, Jerome; Raz, Yuval; Funamoto, Masaki; Shelton, Kenneth T. title: Adult Extracorporeal Membrane Oxygenation Patient Selection During Coronavirus Disease 2019: The Value of a Review Panel During Coronavirus Disease 2019 date: 2020-06-23 journal: Crit Care Med DOI: 10.1097/ccm.0000000000004474 sha: doc_id: 316873 cord_uid: 2gwl9m94 file: cache/cord-317075-zegearxa.json key: cord-317075-zegearxa authors: Madenidou, Anastasia-Vasiliki; Bukhari, Marwan title: Real-life experience of tocilizumab use in COVID-19 patients date: 2020-06-17 journal: Rheumatology (Oxford) DOI: 10.1093/rheumatology/keaa325 sha: doc_id: 317075 cord_uid: zegearxa file: cache/cord-316616-j82q99in.json key: cord-316616-j82q99in authors: Su, Yen-Bo; Kuo, Ming-Jen; Lin, Ting-Yu; Chien, Chian-Shiu; Yang, Yi-Ping; Chou, Shih-Jie; Leu, Hsin-Bang title: Cardiovascular manifestation and treatment in COVID-19 date: 2020-05-19 journal: J Chin Med Assoc DOI: 10.1097/jcma.0000000000000352 sha: doc_id: 316616 cord_uid: j82q99in file: cache/cord-316938-64jxtg9y.json key: cord-316938-64jxtg9y authors: Blasi, Annabel; von Meijenfeldt, Fien A.; Adelmeijer, Jelle; Calvo, Andrea; Ibañez, Cristina; Perdomo, Juan; Carlos Reverter, Juan; Lisman, Ton title: In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation date: 2020-08-06 journal: J Thromb Haemost DOI: 10.1111/jth.15043 sha: doc_id: 316938 cord_uid: 64jxtg9y file: cache/cord-316743-q6gbxghx.json key: cord-316743-q6gbxghx authors: Madhu, S. V. title: Post COVID-19 diabetes care—lessons and challenges date: 2020-06-04 journal: Int J Diabetes Dev Ctries DOI: 10.1007/s13410-020-00831-6 sha: doc_id: 316743 cord_uid: q6gbxghx file: cache/cord-317265-n6x0r58i.json key: cord-317265-n6x0r58i authors: Singh, Varsha title: Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease? date: 2020-07-13 journal: Curr Nutr Rep DOI: 10.1007/s13668-020-00330-4 sha: doc_id: 317265 cord_uid: n6x0r58i file: cache/cord-316764-ps89rxuy.json key: cord-316764-ps89rxuy authors: Liu, Zheng; Zhang, Luo title: At the center of the COVID‐19 pandemic: Lessons learned for otolaryngology‐head and neck surgery in China date: 2020-05-12 journal: Int Forum Allergy Rhinol DOI: 10.1002/alr.22585 sha: doc_id: 316764 cord_uid: ps89rxuy file: cache/cord-317028-f3bpwm5j.json key: cord-317028-f3bpwm5j authors: Olmsted, Russell N. title: Prevention by Design: Construction and Renovation of Health Care Facilities for Patient Safety and Infection Prevention date: 2016-08-09 journal: Infect Dis Clin North Am DOI: 10.1016/j.idc.2016.04.005 sha: doc_id: 317028 cord_uid: f3bpwm5j file: cache/cord-317242-e7000i2u.json key: cord-317242-e7000i2u authors: Gandhi, Darshan; Ahuja, Kriti; Grover, Hemal; Sharma, Pranav; Solanki, Shantanu; Gupta, Nishant; Patel, Love title: Review of X-ray and computed tomography scan findings with a promising role of point of care ultrasound in COVID-19 pandemic date: 2020-09-28 journal: World J Radiol DOI: 10.4329/wjr.v12.i9.195 sha: doc_id: 317242 cord_uid: e7000i2u file: cache/cord-315598-qwh72inx.json key: cord-315598-qwh72inx authors: Mendoza, Jose Luis Accini; Estrada, Victor Hugo Nieto; López, Nelly Beltrán; Bolaños, Elisabeth Ramos; Franco, Daniel Molano; Castell, Carmelo Dueñas; Moreno, Albert Alexander Valencia; Amaya, Iván Camilo Alarcón; Flórez, John Serna; Valencia, Bladimir Alejandro Gil; Camilo Pizarro, G; Polo, Yulieth María Zabaleta; Meza, Carmen Lucia Chica title: ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19 date: 2020-10-06 journal: nan DOI: 10.1016/j.acci.2020.09.004 sha: doc_id: 315598 cord_uid: qwh72inx file: cache/cord-317151-cxx5pcln.json key: cord-317151-cxx5pcln authors: Papa, Alfredo; Papa, Valerio; Lopetuso, Loris Riccardo; Gasbarrini, Antonio; Tursi, Antonio title: Covid-19 and the management of patients with inflammatory bowel disease: a practical decalogue for the post-pandemic phase date: 2020-10-24 journal: Therap Adv Gastroenterol DOI: 10.1177/1756284820968747 sha: doc_id: 317151 cord_uid: cxx5pcln file: cache/cord-317085-qc8bfb9g.json key: cord-317085-qc8bfb9g authors: Zhang, Nan; Wang, Cheng; Zhu, Feng; Mao, Hong; Bai, Peng; Chen, Lu-Lu; Zeng, Tianshu; Peng, Miao-Miao; Qiu, Kang Li; Wang, Yixuan; Yu, Muqing; Xu, Shuyun; Zhao, Jianping; Li, Na; Zhou, Min title: Risk Factors for Poor Outcomes of Diabetes Patients With COVID-19: A Single-Center, Retrospective Study in Early Outbreak in China date: 2020-09-24 journal: Front Endocrinol (Lausanne) DOI: 10.3389/fendo.2020.571037 sha: doc_id: 317085 cord_uid: qc8bfb9g file: cache/cord-317535-zep5axfo.json key: cord-317535-zep5axfo authors: Azpiazu Landa, N.; Velasco Oficialdegui, C.; Intxaurraga Fernández, K.; Gonzalez Larrabe, I.; Riaño Onaindia, S.; Telletxea Benguria, S. title: Ischemic-hemorrhagic stroke in patients with Covid-19 date: 2020-11-07 journal: nan DOI: 10.1016/j.redare.2020.08.001 sha: doc_id: 317535 cord_uid: zep5axfo file: cache/cord-317344-wznzmssz.json key: cord-317344-wznzmssz authors: Iannitti, T.; Palmieri, B. title: Therapeutical use of probiotic formulations in clinical practice date: 2010-06-23 journal: Clin Nutr DOI: 10.1016/j.clnu.2010.05.004 sha: doc_id: 317344 cord_uid: wznzmssz file: cache/cord-317468-pnxni1x5.json key: cord-317468-pnxni1x5 authors: Louie, Philip K.; Barber, Lauren A.; Morse, Kyle W.; Syku, Marie; Qureshi, Sheeraz A.; Lafage, Virginie; Huang, Russel C.; Carli, Alberto V. title: Early Peri-operative Outcomes Were Unchanged in Patients Undergoing Spine Surgery During the COVID-19 Pandemic in New York City date: 2020-09-15 journal: HSS J DOI: 10.1007/s11420-020-09797-x sha: doc_id: 317468 cord_uid: pnxni1x5 file: cache/cord-317604-j8b64a1a.json key: cord-317604-j8b64a1a authors: Sahay, Sandeep; Farber, Harrison W. title: Management of hospitalized patients with pulmonary arterial hypertension and COVID-19 infection date: 2020-06-15 journal: Pulm Circ DOI: 10.1177/2045894020933480 sha: doc_id: 317604 cord_uid: j8b64a1a file: cache/cord-317811-mxsujb5u.json key: cord-317811-mxsujb5u authors: Migliaccio, Raffaella; Bouzigues, Arabella title: Dementia and COVID-19 Lockdown: More Than a Double Blow for Patients and Caregivers date: 2020-07-06 journal: Journal of Alzheimer's disease reports DOI: 10.3233/adr-200193 sha: doc_id: 317811 cord_uid: mxsujb5u file: cache/cord-317566-6ch6na31.json key: cord-317566-6ch6na31 authors: Epstein, Robert S.; Aapro, Matti S.; Basu Roy, Upal K.; Salimi, Tehseen; Krenitsky, JoAnn; Leone-Perkins, Megan L.; Girman, Cynthia; Schlusser, Courtney; Crawford, Jeffrey title: Patient Burden and Real-World Management of Chemotherapy-Induced Myelosuppression: Results from an Online Survey of Patients with Solid Tumors date: 2020-07-08 journal: Adv Ther DOI: 10.1007/s12325-020-01419-6 sha: doc_id: 317566 cord_uid: 6ch6na31 file: cache/cord-317809-umb8j63t.json key: cord-317809-umb8j63t authors: Salari, Abolfazl; Shirkhoda, Mohammad title: COVID-19 pandemic & head and neck cancer patients management: The role of virtual multidisciplinary team meetings date: 2020-04-08 journal: Oral Oncol DOI: 10.1016/j.oraloncology.2020.104693 sha: doc_id: 317809 cord_uid: umb8j63t file: cache/cord-317689-gp4x54pe.json key: cord-317689-gp4x54pe authors: Galanopoulou, Aristea S.; Ferastraoaru, Victor; Correa, Daniel J.; Cherian, Koshi; Duberstein, Susan; Gursky, Jonathan; Hanumanthu, Rajani; Hung, Christine; Molinero, Isaac; Khodakivska, Olga; Legatt, Alan D.; Patel, Puja; Rosengard, Jillian; Rubens, Elayna; Sugrue, William; Yozawitz, Elissa; Mehler, Mark F.; Ballaban‐Gil, Karen; Haut, Sheryl R.; Moshé, Solomon L.; Boro, Alexis title: EEG findings in acutely ill patients investigated for SARS‐CoV‐2/COVID‐19: A small case series preliminary report date: 2020-05-17 journal: Epilepsia Open DOI: 10.1002/epi4.12399 sha: doc_id: 317689 cord_uid: gp4x54pe file: cache/cord-317918-pl625ela.json key: cord-317918-pl625ela authors: Ripa, Marco; Galli, Laura; Poli, Andrea; Oltolini, Chiara; Spagnuolo, Vincenzo; Mastrangelo, Andrea; Muccini, Camilla; Monti, Giacomo; De Luca, Giacomo; Landoni, Giovanni; Dagna, Lorenzo; Clementi, Massimo; Querini, Patrizia Rovere; Ciceri, Fabio; Tresoldi, Moreno; Lazzarin, Adriano; Zangrillo, Alberto; Scarpellini, Paolo; Castagna, Antonella title: Secondary Infections in Patients Hospitalized with COVID-19: Incidence and Predictive Factors date: 2020-10-24 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2020.10.021 sha: doc_id: 317918 cord_uid: pl625ela file: cache/cord-317932-5sqj2klm.json key: cord-317932-5sqj2klm authors: Stevens, Jacob S.; Toma, Katherine; Tanzi-Pfeifer, Susan; Rao, Maya K.; Mohan, Sumit; Gharavi, Ali G.; Radhakrishnan, Jai title: Dashboards to facilitate nephrology disaster planning in the COVID-19 era date: 2020-07-03 journal: Kidney Int Rep DOI: 10.1016/j.ekir.2020.06.033 sha: doc_id: 317932 cord_uid: 5sqj2klm file: cache/cord-318167-b25g6zkp.json key: cord-318167-b25g6zkp authors: Einollahi, Behzad; Cegolon, Luca; Abolghasemi, Hassan; Imanizadeh, Sina; Bahramifar, Ali; Zhao, Shi; Jafari, Ramezan; Javanbakht, Mohammad title: A patient affected by critical COVID-19 pneumonia, successfully treated with convalescent plasma date: 2020-11-05 journal: Transfus Apher Sci DOI: 10.1016/j.transci.2020.102995 sha: doc_id: 318167 cord_uid: b25g6zkp file: cache/cord-318282-ocgfgx9r.json key: cord-318282-ocgfgx9r authors: Boyce, John M; Cookson, Barry; Christiansen, Keryn; Hori, Satoshi; Vuopio-Varkila, Jaana; Kocagöz, Sesin; Öztop, A Yasemin; Vandenbroucke-Grauls, Christina MJE; Harbarth, Stephan; Pittet, Didier title: Meticillin-resistant Staphylococcus aureus date: 2005-10-31 journal: The Lancet Infectious Diseases DOI: 10.1016/s1473-3099(05)70243-7 sha: doc_id: 318282 cord_uid: ocgfgx9r file: cache/cord-318063-bainw3d6.json key: cord-318063-bainw3d6 authors: Haque, Mainul; Sartelli, Massimo; McKimm, Judy; Abu Bakar, Muhamad title: Health care-associated infections – an overview date: 2018-11-15 journal: Infect Drug Resist DOI: 10.2147/idr.s177247 sha: doc_id: 318063 cord_uid: bainw3d6 file: cache/cord-318021-4qrf5m8s.json key: cord-318021-4qrf5m8s authors: Wolfensberger, A.; Jakob, W.; Faes Hesse, M.; Kuster, S.P.; Meier, A.H.; Schreiber, P.W.; Clack, L.; Sax, H. title: Development and validation of a semi-automated surveillance system—lowering the fruit for non-ventilator-associated hospital-acquired pneumonia (nvHAP) prevention() date: 2019-03-25 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2019.03.019 sha: doc_id: 318021 cord_uid: 4qrf5m8s file: cache/cord-317952-4oa9hfb4.json key: cord-317952-4oa9hfb4 authors: Bourgonje, Arno R.; Abdulle, Amaal Eman; Timens, Wim; Hillebrands, Jan‐Luuk; Navis, Gerjan J.; Gordijn, Sanne J.; Bolling, Marieke C.; Dijkstra, Gerard; Voors, Adriaan A.; Osterhaus, Albert D. M. E.; van der Voort, Peter H. J.; Mulder, Douwe J.; van Goor, Harry title: Angiotensin‐converting enzyme‐2 (ACE2), SARS‐CoV‐2 and pathophysiology of coronavirus disease 2019 (COVID‐19) date: 2020-05-17 journal: J Pathol DOI: 10.1002/path.5471 sha: doc_id: 317952 cord_uid: 4oa9hfb4 file: cache/cord-317575-srg9cyqp.json key: cord-317575-srg9cyqp authors: Chien, Chen‐Yu; Wu, Jeng‐Yih; Wang, Ling‐Feng title: Proactive measures for the pandemic COVID‐19 infection in outpatient clinics of Otolaryngology Department date: 2020-06-03 journal: Kaohsiung J Med Sci DOI: 10.1002/kjm2.12235 sha: doc_id: 317575 cord_uid: srg9cyqp file: cache/cord-318094-losjbgn6.json key: cord-318094-losjbgn6 authors: Alan, Nima; Kim, Song; Agarwal, Nitin; Clarke, Jamie; Yealy, Donald M.; Cohen-Gadol, Aaron A.; Sekula, Raymond F. title: Inter-facility transfer of patients with traumatic intracranial hemorrhage and GCS 14–15: The pilot study of a screening protocol by neurosurgeon to avoid unnecessary transfers date: 2020-10-15 journal: J Clin Neurosci DOI: 10.1016/j.jocn.2020.09.050 sha: doc_id: 318094 cord_uid: losjbgn6 file: cache/cord-318311-aakpbbvl.json key: cord-318311-aakpbbvl authors: Du, Na; OuYang, Yingjie; chen, Yong title: The experience of prevention measures taken by the psychiatric hospital during the emergence of asymptomatic patients with COVID-19 date: 2020-05-30 journal: Psychiatry Res DOI: 10.1016/j.psychres.2020.113109 sha: doc_id: 318311 cord_uid: aakpbbvl file: cache/cord-317966-ut6tzc8s.json key: cord-317966-ut6tzc8s authors: Kocak, Burak; Arpali, Emre; Akyollu, Basak; Yelken, Berna; Tekin, Suda; Kanbay, Mehmet; Turkmen, Aydin; Kalayoglu, Munci title: A Case Report of Oligosymptomatic Kidney Transplant Patients with COVID-19: Do They Pose a Risk to Other Recipients? date: 2020-05-15 journal: Transplant Proc DOI: 10.1016/j.transproceed.2020.05.028 sha: doc_id: 317966 cord_uid: ut6tzc8s file: cache/cord-318229-29cgwivt.json key: cord-318229-29cgwivt authors: Baier, Claas; Haid, Sibylle; Beilken, Andreas; Behnert, Astrid; Wetzke, Martin; Brown, Richard J. P.; Schmitt, Corinna; Ebadi, Ella; Hansen, Gesine; Schulz, Thomas F.; Pietschmann, Thomas; Bange, Franz-Christoph title: Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease date: 2018-02-13 journal: Antimicrob Resist Infect Control DOI: 10.1186/s13756-018-0316-2 sha: doc_id: 318229 cord_uid: 29cgwivt file: cache/cord-318694-370ccaoc.json key: cord-318694-370ccaoc authors: Khanna, Niharika; Klyushnenkova, Elena N.; Kaysin, Alexander; Stewart, David L. title: Utilizing the Learning Health System Adaptation to guide Family Medicine Practice to COVID-19 response date: 2020-10-16 journal: J Prim Care Community Health DOI: 10.1177/2150132720966409 sha: doc_id: 318694 cord_uid: 370ccaoc file: cache/cord-318262-w8oixzdg.json key: cord-318262-w8oixzdg authors: Chevance, A; Gourion, D; Hoertel, N; Llorca, P-M; Thomas, P; Bocher, R; Moro, M-R; Laprévote, V; Benyamina, A; Fossati, P; Masson, M; Leaune, E; Leboyer, M; Gaillard, R title: Ensuring mental health care during the SARS-CoV-2 epidemic in France: a narrative review date: 2020-04-22 journal: Encephale DOI: 10.1016/j.encep.2020.04.005 sha: doc_id: 318262 cord_uid: w8oixzdg file: cache/cord-318355-38x3f3ee.json key: cord-318355-38x3f3ee authors: Yang, Yang; Ding, Lin; Zou, Xianlun; Shen, Yaqi; Hu, Daoyu; Hu, Xuemei; Li, Zhen; Kamel, Ihab R. title: Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with Sars‐COV‐2 date: 2020-07-17 journal: Obesity (Silver Spring) DOI: 10.1002/oby.22971 sha: doc_id: 318355 cord_uid: 38x3f3ee file: cache/cord-318333-rzhrgp5q.json key: cord-318333-rzhrgp5q authors: Hou, Jiabao; Wan, Xing; Shen, Qianni; Zhu, Jie; Leng, Yan; Zhao, Bo; Xia, Zhongyuan; He, Yuhong; Wu, Yang title: COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study date: 2020-09-03 journal: Int J Surg DOI: 10.1016/j.ijsu.2020.08.037 sha: doc_id: 318333 cord_uid: rzhrgp5q file: cache/cord-318909-h5b7mncf.json key: cord-318909-h5b7mncf authors: Liguori, Claudio; Pierantozzi, Mariangela; Spanetta, Matteo; Sarmati, Loredana; Cesta, Novella; Iannetta, Marco; Ora, Josuel; Genga Mina, Grazia; Puxeddu, Ermanno; Balbi, Ottavia; Pezzuto, Gabriella; Magrini, Andrea; Rogliani, Paola; Andreoni, Massimo; Biagio Mercuri, Nicola title: Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection date: 2020-05-19 journal: Brain Behav Immun DOI: 10.1016/j.bbi.2020.05.037 sha: doc_id: 318909 cord_uid: h5b7mncf file: cache/cord-318954-pj5lsvsa.json key: cord-318954-pj5lsvsa authors: Arabi, Yaseen; Balkhy, Hanan; Hajeer, Ali H.; Bouchama, Abderrezak; Hayden, Frederick G.; Al-Omari, Awad; Al-Hameed, Fahad M.; Taha, Yusri; Shindo, Nahoko; Whitehead, John; Merson, Laura; AlJohani, Sameera; Al-Khairy, Khalid; Carson, Gail; Luke, Thomas C.; Hensley, Lisa; Al-Dawood, Abdulaziz; Al-Qahtani, Saad; Modjarrad, Kayvon; Sadat, Musharaf; Rohde, Gernot; Leport, Catherine; Fowler, Robert title: Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol date: 2015-11-19 journal: Springerplus DOI: 10.1186/s40064-015-1490-9 sha: doc_id: 318954 cord_uid: pj5lsvsa file: cache/cord-318803-xpa49sxt.json key: cord-318803-xpa49sxt authors: McFee, Robin B. title: Gulf War Servicemen and Servicewomen: The Long Road Home and the Role of Health Care Professionals to Enhance the Troops' Health and Healing date: 2008-05-31 journal: Disease-a-Month DOI: 10.1016/j.disamonth.2008.02.002 sha: doc_id: 318803 cord_uid: xpa49sxt file: cache/cord-318326-q9fnbg8n.json key: cord-318326-q9fnbg8n authors: Cacciapuoti, Sara; De Rosa, Annunziata; Gelzo, Monica; Megna, Matteo; Raia, Maddalena; Pinchera, Biagio; Pontarelli, Agostina; Scotto, Riccardo; Scala, Emanuele; Scarano, Francesco; Scalia, Giulia; Castaldo, Giuseppe; Fabbrocini, Gabriella; Gentile, Ivan; Parrella, Roberto title: Immunocytometric analysis of COVID patients: A contribution to personalized therapy? date: 2020-08-29 journal: Life Sci DOI: 10.1016/j.lfs.2020.118355 sha: doc_id: 318326 cord_uid: q9fnbg8n file: cache/cord-318873-zwot69s3.json key: cord-318873-zwot69s3 authors: Braunstein, Eric D.; Reynbakh, Olga; Krumerman, Andrew; Di Biase, Luigi; Ferrick, Kevin J. title: Inpatient Cardiac Monitoring Using a Patch‐Based Mobile Cardiac Telemetry System During the COVID‐19 Pandemic date: 2020-08-27 journal: J Cardiovasc Electrophysiol DOI: 10.1111/jce.14727 sha: doc_id: 318873 cord_uid: zwot69s3 file: cache/cord-318830-a3n4c5d1.json key: cord-318830-a3n4c5d1 authors: Brook, Olga R.; Piper, Kimberly G.; Mercado, Noe B.; Gebre, Makda S.; Barouch, Dan H.; Busman-Sahay, Kathleen; Starke, Carly E.; Estes, Jacob D.; Martinot, Amanda J.; Wrijil, Linda; Ducat, Sarah; Hecht, Jonathan L. title: Feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients date: 2020-09-17 journal: Abdom Radiol (NY) DOI: 10.1007/s00261-020-02753-7 sha: doc_id: 318830 cord_uid: a3n4c5d1 file: cache/cord-318944-13zk6cco.json key: cord-318944-13zk6cco authors: Bizzoca, Maria Eleonora; Campisi, Giuseppina; Lo Muzio, Lorenzo title: Covid-19 Pandemic: What Changes for Dentists and Oral Medicine Experts? A Narrative Review and Novel Approaches to Infection Containment date: 2020-05-27 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17113793 sha: doc_id: 318944 cord_uid: 13zk6cco file: cache/cord-318369-y3wtfqrn.json key: cord-318369-y3wtfqrn authors: Pan, Lingai; Zeng, Jie; Pu, Hong; Peng, Shengkun title: How to optimize the Radiology protocol during the global COVID-19 epidemic: Keypoints from Sichuan Provincial People's Hospital date: 2020-08-05 journal: Clin Imaging DOI: 10.1016/j.clinimag.2020.07.008 sha: doc_id: 318369 cord_uid: y3wtfqrn file: cache/cord-319037-77l9wdyb.json key: cord-319037-77l9wdyb authors: Gavriilaki, Eleni; Sakellari, Ioanna; Gavriilaki, Maria; Anagnostopoulos, Achilles title: A New Era in Endothelial Injury Syndromes: Toxicity of CAR-T Cells and the Role of Immunity date: 2020-05-29 journal: Int J Mol Sci DOI: 10.3390/ijms21113886 sha: doc_id: 319037 cord_uid: 77l9wdyb file: cache/cord-319333-jwbgytwd.json key: cord-319333-jwbgytwd authors: Radmard, Sara; Epstein, Samantha E.; Roeder, Hannah J.; Michalak, Andrew J.; Shapiro, Steven D.; Boehme, Amelia; Wilson, Tommy J.; Duran, Juan C.; Bain, Jennifer M.; Willey, Joshua Z.; Thakur, Kiran T. title: Inpatient Neurology Consultations During the Onset of the SARS-CoV-2 New York City Pandemic: A Single Center Case Series date: 2020-07-10 journal: Front Neurol DOI: 10.3389/fneur.2020.00805 sha: doc_id: 319333 cord_uid: jwbgytwd file: cache/cord-318312-v1c3qm7h.json key: cord-318312-v1c3qm7h authors: Fischer, Quentin; Darmon, Arthur; Ducrocq, Grégory; Feldman, Laurent title: Case report of anterior ST-elevation myocardial infarction in a patient with coronavirus disease-2019 date: 2020-05-19 journal: Eur Heart J Case Rep DOI: 10.1093/ehjcr/ytaa131 sha: doc_id: 318312 cord_uid: v1c3qm7h file: cache/cord-318520-hgjv7ot9.json key: cord-318520-hgjv7ot9 authors: Mohamed, Sherif; Abo El-Hassan, Osama; Rizk, Magda; Ismail, Jumana H; Baioumy, Aml title: Death due to Cardiac Arrest in a Young Female With Highly Suspected COVID-19: A Case Report date: 2020-08-30 journal: Cureus DOI: 10.7759/cureus.10127 sha: doc_id: 318520 cord_uid: hgjv7ot9 file: cache/cord-319400-lghjiw5p.json key: cord-319400-lghjiw5p authors: Chaix, B.; Delamon, G.; Guillemasse, A.; Brouard, B.; Bibault, J.-E. title: Psychological Distress during the COVID-19 pandemic in France: a national assessment of at-risk populations date: 2020-05-15 journal: nan DOI: 10.1101/2020.05.10.20093161 sha: doc_id: 319400 cord_uid: lghjiw5p file: cache/cord-319742-ypkt01rn.json key: cord-319742-ypkt01rn authors: Asgharpour, Masoumeh; Mehdinezhad, Hamed; Bayani, Masoumeh; Zavareh, Mahmoud Sadeghi Haddad; Hamidi, Seyed Hossein; Akbari, Roghayeh; Ghadimi, Reza; Bijani, Ali; Mouodi, Simin title: Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19) date: 2020-08-20 journal: BMC Nephrol DOI: 10.1186/s12882-020-02020-3 sha: doc_id: 319742 cord_uid: ypkt01rn file: cache/cord-319849-3shr5grg.json key: cord-319849-3shr5grg authors: Cheruiyot, Isaac; Sehmi, Prabjot; Ominde, Beryl; Bundi, Paul; Mislani, Musa; Ngure, Brian; Olabu, Beda; Ogeng’o, Julius A. title: Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients date: 2020-11-03 journal: Neurol Sci DOI: 10.1007/s10072-020-04870-z sha: doc_id: 319849 cord_uid: 3shr5grg file: cache/cord-319930-ymqnb54a.json key: cord-319930-ymqnb54a authors: Kremer, Stéphane; Lersy, François; de Sèze, Jérome; Ferré, Jean-Christophe; Maamar, Adel; Carsin-Nicol, Béatrice; Collange, Olivier; Bonneville, Fabrice; Adam, Gilles; Martin-Blondel, Guillaume; Rafiq, Marie; Geeraerts, Thomas; Delamarre, Louis; Grand, Sylvie; Krainik, Alexandre; Caillard, Sophie; Marc Constans, Jean; Metanbou, Serge; Heintz, Adrien; Helms, Julie; Schenck, Maleka; Lefèbvre, Nicolas; Boutet, Claire; Fabre, Xavier; Forestier, Géraud; de Beaurepaire, Isaure; Bornet, Grégoire; Lacalm, Audrey; Oesterlé, Hélène; Bolognini, Federico; Messie, Julien; Hmeydia, Ghazi; Benzakoun, Joseph; Oppenheim, Catherine; Bapst, Blanche; Megdiche, Imen; Henri-Feugeas, Marie-Cécile; Khalil, Antoine; Gaudemer, Augustin; Jager, Lavinia; Nesser, Patrick; Talla Mba, Yannick; Hemmert, Céline; Feuerstein, Philippe; Sebag, Nathan; Carré, Sophie; Alleg, Manel; Lecocq, Claire; Schmitt, Emmanuelle; Anxionnat, René; Zhu, François; Comby, Pierre-Olivier; Ricolfi, Frédéric; Thouant, Pierre; Desal, Hubert; Boulouis, Grégoire; Berge, Jérome; Kazémi, Apolline; Pyatigorskaya, Nadya; Lecler, Augustin; Saleme, Suzana; Edjlali-Goujon, Myriam; Kerleroux, Basile; Zorn, Pierre-Emmanuel; Mathieu, Muriel; Baloglu, Seyyid; Ardellier, François-Daniel; Willaume, Thibault; Brisset, Jean Christophe; Boulay, Clotilde; Mutschler, Véronique; Hansmann, Yves; Mertes, Paul-Michel; Schneider, Francis; Fafi-Kremer, Samira; Ohana, Mickael; Meziani, Ferhat; David, Jean-Stéphane; Meyer, Nicolas; Anheim, Mathieu; Cotton, Pr François title: Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study date: 2020-06-16 journal: Radiology DOI: 10.1148/radiol.2020202222 sha: doc_id: 319930 cord_uid: ymqnb54a file: cache/cord-319218-mejvlkfg.json key: cord-319218-mejvlkfg authors: Marandino, Laura; Di Maio, Massimo; Procopio, Giuseppe; Cinieri, Saverio; Beretta, Giordano Domenico; Necchi, Andrea title: The Shifting Landscape of Genitourinary Oncology During the COVID-19 Pandemic and how Italian Oncologists Reacted: Results from a National Survey date: 2020-04-20 journal: Eur Urol DOI: 10.1016/j.eururo.2020.04.004 sha: doc_id: 319218 cord_uid: mejvlkfg file: cache/cord-318808-1cfwj5uq.json key: cord-318808-1cfwj5uq authors: Li, Ying; Wang, Haizhou; Wang, Fan; Du, Hui; Liu, Xueru; Chen, Peng; Wang, Yanli; Lu, Xiaoxia title: Comparison of Hospitalized Patients with pneumonia caused by COVID-19 and influenza A in children under 5 years date: 2020-06-12 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.06.026 sha: doc_id: 318808 cord_uid: 1cfwj5uq file: cache/cord-319567-4t5t8bcx.json key: cord-319567-4t5t8bcx authors: Şentürk, Mert; Tahan, Mohamed R. El; SZEGEDI, Laszlo L.; Marczin, Nandor; Karzai, Waheedullah; Shelley, Ben; Piccioni, Federico; Gil, Manuel Granell; Rex, Steffen; Bence, Johan; Cohen, Edmond; Gregorio, Guido Di; Drnvsek-Globoikar, Mojca; Jimenez, Maria-José; Licker, Marc-Josephjo; Mourisse, Jo; Mukherjee, Chirojit; Navarro-Ripolli, Ricard; Neskovic, Vojislava; Paloczi, Balazs; Paternoster, Gianluca; Pelosi, Paolo; Salaheldeen, Ahmed; Stoica, Radu; Unzueta, Carmen; Vanpeteghem, Caroline; Vegh, Tamas; Wouters, Patrick; Yapici, Davud; Guarracino, Fabio title: Thoracic Anesthesia of Patients with Suspected or Confirmed 2019 Novel Coronavirus Infection: Preliminary Recommendations for Airway Management by the EACTA Thoracic Subspecialty Committee date: 2020-04-11 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.03.059 sha: doc_id: 319567 cord_uid: 4t5t8bcx file: cache/cord-319615-p2labgd8.json key: cord-319615-p2labgd8 authors: Schulman, Sam title: Coronavirus Disease 2019, Prothrombotic Factors, and Venous Thromboembolism date: 2020-05-11 journal: Semin Thromb Hemost DOI: 10.1055/s-0040-1710337 sha: doc_id: 319615 cord_uid: p2labgd8 file: cache/cord-320445-pdvkyzci.json key: cord-320445-pdvkyzci authors: Fry, Alicia M.; Lu, Xiaoyan; Chittaganpitch, Malinee; Peret, Teresa; Fischer, Julie; Dowell, Scott F.; Anderson, Larry J.; Erdman, Dean; Olsen, Sonja J. title: Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand date: 2007-04-01 journal: J Infect Dis DOI: 10.1086/512163 sha: doc_id: 320445 cord_uid: pdvkyzci file: cache/cord-320572-94fvtj4a.json key: cord-320572-94fvtj4a authors: Wendel Garcia, Pedro David; Fumeaux, Thierry; Guerci, Philippe; Heuberger, Dorothea Monika; Montomoli, Jonathan; Roche-Campo, Ferran; Schuepbach, Reto Andreas; Hilty, Matthias Peter title: Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort date: 2020-07-06 journal: EClinicalMedicine DOI: 10.1016/j.eclinm.2020.100449 sha: doc_id: 320572 cord_uid: 94fvtj4a file: cache/cord-319013-oytqcifa.json key: cord-319013-oytqcifa authors: Focosi, Daniele; Anderson, Arthur O.; Tang, Julian W.; Tuccori, Marco title: Convalescent Plasma Therapy for COVID-19: State of the Art date: 2020-08-12 journal: Clin Microbiol Rev DOI: 10.1128/cmr.00072-20 sha: doc_id: 319013 cord_uid: oytqcifa file: cache/cord-320612-vam0bli3.json key: cord-320612-vam0bli3 authors: Höring, Steffen; Fussen, René; Neusser, Johannes; Kleines, Michael; Laurentius, Thea; Bollheimer, Leo Cornelius; Keller, Doris; Lemmen, Sebastian title: Management of a Hospital-Wide COVID-19 Outbreak Affecting Patients and Healthcare Workers date: 2020-10-26 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00597-2 sha: doc_id: 320612 cord_uid: vam0bli3 file: cache/cord-320149-3q4q98a6.json key: cord-320149-3q4q98a6 authors: Di Carlo, Davide Tiziano; Montemurro, Nicola; Petrella, Giandomenico; Siciliano, Gabriele; Ceravolo, Roberto; Perrini, Paolo title: Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature date: 2020-08-01 journal: J Neurol DOI: 10.1007/s00415-020-09978-y sha: doc_id: 320149 cord_uid: 3q4q98a6 file: cache/cord-320184-wacoz5t9.json key: cord-320184-wacoz5t9 authors: Thirumalaikolundusubramanian, Ponniah; Meenakshisundaram, Ramachandran; Senthilkumaran, Subramanian title: Ethics, Legality, and Education in the Practice of Cardiology date: 2014-08-15 journal: Heart and Toxins DOI: 10.1016/b978-0-12-416595-3.00023-2 sha: doc_id: 320184 cord_uid: wacoz5t9 file: cache/cord-320349-6hbuq0k7.json key: cord-320349-6hbuq0k7 authors: Zhou, Hua; Huang, Huibin; Xie, Xiaolei; Gao, Jiandong; Wu, Ji; Zhu, Yan; He, Wei; Liu, Jingyuan; Li, Ang; Xu, Yuan title: Development of early warning and rapid response system for patients with novel coronavirus pneumonia (COVID-19): A research protocol date: 2020-08-21 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000021874 sha: doc_id: 320349 cord_uid: 6hbuq0k7 file: cache/cord-320599-hxn4bgec.json key: cord-320599-hxn4bgec authors: Liontos, Michalis; Kaparelou, Maria; Karofylakis, Emmanouil; Kavatha, Dimitra; Mentis, Andreas; Zagouri, Flora; Terpos, Evangelos; Dimopoulos, Meletios-Athanasios title: Chemotherapy resumption in ovarian cancer patient diagnosed with COVID-19 date: 2020-07-30 journal: Gynecol Oncol Rep DOI: 10.1016/j.gore.2020.100615 sha: doc_id: 320599 cord_uid: hxn4bgec file: cache/cord-320788-ln8ddyuj.json key: cord-320788-ln8ddyuj authors: Wang, Chun-Hua; Liu, Chien-Ying; Wan, Yung-Liang; Chou, Chun-Liang; Huang, Kuo-Hsiung; Lin, Horng-Chyuan; Lin, Shu-Min; Lin, Tzou-Yien; Chung, Kian Fan; Kuo, Han-Pin title: Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS date: 2005-05-11 journal: Respir Res DOI: 10.1186/1465-9921-6-42 sha: doc_id: 320788 cord_uid: ln8ddyuj file: cache/cord-320811-9sm7iz5x.json key: cord-320811-9sm7iz5x authors: Harkin, Denis W. title: Ethics for surgeons during the COVID-19 pandemic, review article date: 2020-06-08 journal: Ann Med Surg (Lond) DOI: 10.1016/j.amsu.2020.06.003 sha: doc_id: 320811 cord_uid: 9sm7iz5x file: cache/cord-319805-b6ypt5d0.json key: cord-319805-b6ypt5d0 authors: Siepmann, Timo; Sedghi, Annahita; Barlinn, Jessica; de With, Katja; Mirow, Lutz; Wolz, Martin; Gruenewald, Thomas; Helbig, Sina; Schroettner, Percy; Winzer, Simon; von Bonin, Simone; Moustafa, Haidar; Pallesen, Lars-Peder; Rosengarten, Bernhard; Schubert, Joerg; Gueldner, Andreas; Spieth, Peter; Koch, Thea; Bornstein, Stefan; Reichmann, Heinz; Puetz, Volker; Barlinn, Kristian title: Association of history of cerebrovascular disease with severity of COVID-19 date: 2020-08-06 journal: J Neurol DOI: 10.1007/s00415-020-10121-0 sha: doc_id: 319805 cord_uid: b6ypt5d0 file: cache/cord-319823-sp5wibeh.json key: cord-319823-sp5wibeh authors: Brown, Sherry-Ann; Rhee, June-Wha; Guha, Avirup; Rao, Vijay U. title: Innovation in Precision Cardio-Oncology During the Coronavirus Pandemic and Into a Post-pandemic World date: 2020-08-14 journal: Front Cardiovasc Med DOI: 10.3389/fcvm.2020.00145 sha: doc_id: 319823 cord_uid: sp5wibeh file: cache/cord-320634-x7a3k5xu.json key: cord-320634-x7a3k5xu authors: Salna, Michael; Argenziano, Michael; George, Isaac title: Reply: A problem of “ethic” proportions date: 2020-08-11 journal: J Thorac Cardiovasc Surg DOI: 10.1016/j.jtcvs.2020.07.030 sha: doc_id: 320634 cord_uid: x7a3k5xu file: cache/cord-320267-n21jryi2.json key: cord-320267-n21jryi2 authors: AlShoaibi, Naeem A.; Maghrabi, Khadijah; Alanazi, Haitham; Harbi, Mousa Al; Alghamdi, Saleh title: Saudi Heart Rhythm Society Task Force on Management of Potential Arrhythmogenicity Associated with Pharmacotherapy for COVID-19 date: 2020-09-20 journal: Ann Saudi Med DOI: 10.5144/0256-4947.2020.365 sha: doc_id: 320267 cord_uid: n21jryi2 file: cache/cord-320477-zbp8a8dr.json key: cord-320477-zbp8a8dr authors: Fung, Timothy H.M.; Kuet, Mong‐Loon; Patel, Moneesh K.; Puri, Pankaj title: Addressing COVID‐19 fear to improve clinic attendance for patients with wet age‐related macular degeneration date: 2020-06-18 journal: Acta Ophthalmol DOI: 10.1111/aos.14520 sha: doc_id: 320477 cord_uid: zbp8a8dr file: cache/cord-321346-epsp3bbm.json key: cord-321346-epsp3bbm authors: Luppa, Peter B.; Müller, Carolin; Schlichtiger, Alice; Schlebusch, Harald title: Point-of-care testing (POCT): Current techniques and future perspectives date: 2011-03-21 journal: Trends Analyt Chem DOI: 10.1016/j.trac.2011.01.019 sha: doc_id: 321346 cord_uid: epsp3bbm file: cache/cord-320632-369kax2m.json key: cord-320632-369kax2m authors: Song, Yang; Zhang, Min; Yin, Ling; Wang, Kunkun; Zhou, Yiyi; Zhou, Mi; Lu, Yun title: COVID-19 Treatment: Close to a Cure? – A Rapid Review of Pharmacotherapies for the Novel Coronavirus date: 2020-07-04 journal: Int J Antimicrob Agents DOI: 10.1016/j.ijantimicag.2020.106080 sha: doc_id: 320632 cord_uid: 369kax2m file: cache/cord-320877-1i0hzfjk.json key: cord-320877-1i0hzfjk authors: KIYKAÇ ALTINBAŞ, Şadıman; TAPISIZ, Ömer Lütfi; ENGİN ÜSTÜN, Yaprak title: Gynecological laparoscopic surgery in the shade of COVID-19 pandemic date: 2020-06-23 journal: Turk J Med Sci DOI: 10.3906/sag-2004-272 sha: doc_id: 320877 cord_uid: 1i0hzfjk file: cache/cord-321064-pe8466n1.json key: cord-321064-pe8466n1 authors: Saraceni, Francesco; Scortechini, Ilaria; Mancini, Giorgia; Mariani, Marianna; Federici, Irene; Gaetani, Mariana; Barbatelli, Paolo; Minnucci, Maria Luisa; Bagnarelli, Patrizia; Olivieri, Attilio title: Severe COVID‐19 in a patient with chronic graft‐versus‐host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib date: 2020-07-14 journal: Transpl Infect Dis DOI: 10.1111/tid.13401 sha: doc_id: 321064 cord_uid: pe8466n1 file: cache/cord-320663-xypg6evo.json key: cord-320663-xypg6evo authors: Market, Marisa; Angka, Leonard; Martel, Andre B.; Bastin, Donald; Olanubi, Oladunni; Tennakoon, Gayashan; Boucher, Dominique M.; Ng, Juliana; Ardolino, Michele; Auer, Rebecca C. title: Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies date: 2020-06-23 journal: Front Immunol DOI: 10.3389/fimmu.2020.01512 sha: doc_id: 320663 cord_uid: xypg6evo file: cache/cord-320892-dcfi5u04.json key: cord-320892-dcfi5u04 authors: Kaidi, Austin C.; Held, Michael B.; Boddapati, Venkat; Trofa, David P.; Neuwirth, Alexander L. title: Timing and Tips for Total Hip Arthroplasty in a Critically Ill COVID-19 Patient with a Femoral Neck Fracture: A Case Report date: 2020-07-14 journal: Arthroplast Today DOI: 10.1016/j.artd.2020.07.006 sha: doc_id: 320892 cord_uid: dcfi5u04 file: cache/cord-319706-2e9jrv0s.json key: cord-319706-2e9jrv0s authors: Ebinger, Joseph E.; Achamallah, Natalie; Ji, Hongwei; Claggett, Brian L.; Sun, Nancy; Botting, Patrick; Nguyen, Trevor-Trung; Luong, Eric; Kim, Elizabeth H.; Park, Eunice; Liu, Yunxian; Rosenberry, Ryan; Matusov, Yuri; Zhao, Steven; Pedraza, Isabel; Zaman, Tanzira; Thompson, Michael; Raedschelders, Koen; Berg, Anders H.; Grein, Jonathan D.; Noble, Paul W.; Chugh, Sumeet S.; Bairey Merz, C. Noel; Marbán, Eduardo; Van Eyk, Jennifer E.; Solomon, Scott D.; Albert, Christine M.; Chen, Peter; Cheng, Susan title: Pre-existing traits associated with Covid-19 illness severity date: 2020-07-23 journal: PLoS One DOI: 10.1371/journal.pone.0236240 sha: doc_id: 319706 cord_uid: 2e9jrv0s file: cache/cord-320864-k9zksbyt.json key: cord-320864-k9zksbyt authors: Remes-Troche, J. M.; Valdovinos-Diaz, M. A.; Viebig, R.; Defilippi, C.; Bustos-Fernández, L. M.; Sole, L.; Hani-Amador, A. C. title: Recommendations for the reopening and activity resumption of the neurogastroenterology units in the face of the COVID-19 pandemic. Position of the Sociedad Latinoamericana de Neurogastroenterología date: 2020-11-01 journal: nan DOI: 10.1016/j.rgmxen.2020.07.004 sha: doc_id: 320864 cord_uid: k9zksbyt file: cache/cord-321543-qdmvn44h.json key: cord-321543-qdmvn44h authors: Webb, J. B.; Bray, A.; Asare, P. K.; Clipp, R. B.; Mehta, Y. B.; Penupolu, S.; Patel, A. A.; Poler, S. M. title: Computational Simulation to Assess Patient Safety of Uncompensated COVID-19 Two-patient Ventilator Sharing Using the Pulse Physiology Engine date: 2020-05-26 journal: nan DOI: 10.1101/2020.05.19.20107201 sha: doc_id: 321543 cord_uid: qdmvn44h file: cache/cord-321149-hffj7s4o.json key: cord-321149-hffj7s4o authors: Schmidt, Matthieu; Hajage, David; Lebreton, Guillaume; Monsel, Antoine; Voiriot, Guillaume; Levy, David; Baron, Elodie; Beurton, Alexandra; Chommeloux, Juliette; Meng, Paris; Nemlaghi, Safaa; Bay, Pierre; Leprince, Pascal; Demoule, Alexandre; Guidet, Bertrand; Constantin, Jean Michel; Fartoukh, Muriel; Dres, Martin; Combes, Alain; Luyt, Charles-Edouard; Hekimian, Guillaume; Brechot, Nicolas; Pineton de Chambrun, Marc; Desnos, Cyrielle; Arzoine, Jeremy; Guerin, Emmanuelle; Schoell, Thibaut; Demondion, Pierre; Juvin, Charles; Nardonne, Nathalie; Marin, Sofica; D'Alessandro, Cossimo; Nguyen, Bao-Long; Quemeneur, Cyril; James, Arthur; Assefi, Mona; Lepere, Victoria; Savary, Guillaume; Gibelin, Aude; Turpin, Matthieu; Elabbadi, Alexandre; Berti, Enora; Vezinet, Corinne; Bonvallot, Harold; Delmotte, Pierre-Romain; De Sarcus, Martin; Du Fayet De La Tour, Charlotte; Abbas, Samia; Maury, Eric; Baudel, Jean-Luc; Lavillegrand, Jean-Remi; Ait Oufella, Hafid; Abdelkrim, Abdelmalek; Urbina, Thomas; Virolle, Sara; Deleris, Robin; Bonny, Vincent; Le Marec, Julien; Mayaux, Julien; Morawiec, Elise title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 journal: The Lancet Respiratory Medicine DOI: 10.1016/s2213-2600(20)30328-3 sha: doc_id: 321149 cord_uid: hffj7s4o file: cache/cord-320695-gq7k331z.json key: cord-320695-gq7k331z authors: Sairras, Shellice; Baldew, Se-Sergio; van der Hilst, Kwame; Shankar, Arti; Zijlmans, Wilco; Lichtveld, Maureen; Ferdinand, Keith title: Heart Failure Hospitalizations and Risk Factors among the Multi-Ethnic Population from a Middle Income Country: The Suriname Heart Failure Studies date: 2020-09-11 journal: J Natl Med Assoc DOI: 10.1016/j.jnma.2020.08.010 sha: doc_id: 320695 cord_uid: gq7k331z file: cache/cord-321030-isc3p46t.json key: cord-321030-isc3p46t authors: Rodriguez Socarrás, Moises; Loeb, Stacy; Teoh, Jeremy Yuen-Chun; Ribal, Maria J.; Bloemberg, Jarka; Catto, James; N’Dow, James; Van Poppel, Hendrik; Gómez Rivas, Juan title: Telemedicine and Smart Working: Recommendations of the European Association of Urology date: 2020-07-10 journal: Eur Urol DOI: 10.1016/j.eururo.2020.06.031 sha: doc_id: 321030 cord_uid: isc3p46t file: cache/cord-320831-owfnttqr.json key: cord-320831-owfnttqr authors: Klimek, Ludger; Pfaar, Oliver; Worm, Margitta; Bergmann, Karl-Christian; Bieber, Thomas; Buhl, Roland; Buters, Jeroen; Darsow, Ulf; Keil, Thomas; Kleine-Tebbe, Jörg; Lau, Susanne; Maurer, Marcus; Merk, Hans; Mösges, Ralph; Saloga, Joachim; Staubach, Petra; Stute, Petra; Rabe, Klaus; Rabe, Uta; Vogelmeier, Claus; Biedermann, Tilo; Jung, Kirsten; Schlenter, Wolfgang; Ring, Johannes; Chaker, Adam; Wehrmann, Wolfgang; Becker, Sven; Mülleneisen, Norbert; Nemat, Katja; Czech, Wofgang; Wrede, Holger; Brehler, Randolf; Fuchs, Thomas; Tomazic, Peter-Valentin; Aberer, Werner; Fink-Wagner, Antje; Horak, Friedrich; Wöhrl, Stefan; Niederberger-Leppin, Verena; Pali-Schöll, Isabella; Pohl, Wolfgang; Roller-Wirnsberger, Regina; Spranger, Otto; Valenta, Rudolf; Akdis, Mübecell; Akdis, Cezmi; Hoffmann-Sommergruber, Karin; Jutel, Marek; Matricardi, Paolo; Spertin, FranÇois; Khaltaev, Nikolai; Michel, Jean-Pierre; Nicod, Laurent; Schmid-Grendelmeier, Peter; Hamelmann, Eckard; Jakob, Thilo; Werfel, Thomas; Wagenmann, Martin; Taube, Christian; Gerstlauer, Michael; Vogelberg, Christian; Bousquet, Jean; Zuberbier, Torsten title: Allergen immunotherapy in the current COVID-19 pandemic: A position paper of AeDA, ARIA, EAACI, DGAKI and GPA: Position paper of the German ARIA Group(A) in cooperation with the Austrian ARIA Group(B), the Swiss ARIA Group(C), German Society for Applied Allergology (AEDA)(D), German Society for Allergology and Clinical Immunology (DGAKI)(E), Society for Pediatric Allergology (GPA)(F) in cooperation with AG Clinical Immunology, Allergology and Environmental Medicine of the DGHNO-KHC(G) and the European Academy of Allergy and Clinical Immunology (EAACI)(H) date: 2020-05-28 journal: Allergol Select DOI: 10.5414/alx02147e sha: doc_id: 320831 cord_uid: owfnttqr file: cache/cord-321311-v2i1caug.json key: cord-321311-v2i1caug authors: Weller, Michael; Preusser, Matthias title: How we treat patients with brain tumour during the COVID-19 pandemic date: 2020-05-13 journal: ESMO Open DOI: 10.1136/esmoopen-2020-000789 sha: doc_id: 321311 cord_uid: v2i1caug file: cache/cord-321748-9a54ekac.json key: cord-321748-9a54ekac authors: Kim, Sang Il; Lee, Ji Yong title: Walk-Through Screening Center for COVID-19: an Accessible and Efficient Screening System in a Pandemic Situation date: 2020-04-14 journal: J Korean Med Sci DOI: 10.3346/jkms.2020.35.e154 sha: doc_id: 321748 cord_uid: 9a54ekac file: cache/cord-321768-oevswvvd.json key: cord-321768-oevswvvd authors: Duan, Ya-qi; Xia, Ming-hui; Ren, Liang; Zhang, Yan-fang; Ao, Qi-lin; Xu, San-peng; Kuang, Dong; Liu, Qian; Yan, Bing; Zhou, Yi-wu; Chu, Qian; Liu, Liang; Yang, Xiang-Ping; Wang, Guo-ping title: Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients date: 2020-08-07 journal: Curr Med Sci DOI: 10.1007/s11596-020-2225-x sha: doc_id: 321768 cord_uid: oevswvvd file: cache/cord-321461-1s3y9kc5.json key: cord-321461-1s3y9kc5 authors: Rajdev, Kartikeya; Lahan, Shubham; Klein, Kate; Piquette, Craig A; Thi, Meilinh title: Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting Evidence date: 2020-08-31 journal: Cureus DOI: 10.7759/cureus.10157 sha: doc_id: 321461 cord_uid: 1s3y9kc5 file: cache/cord-321594-x5wv9p7n.json key: cord-321594-x5wv9p7n authors: Jiang, Wen; Magit, Anthony E.; Carvalho, Daniela title: Equal Access to Telemedicine during COVID‐19 Pandemic: A Pediatric Otolaryngology Perspective date: 2020-10-05 journal: Laryngoscope DOI: 10.1002/lary.29164 sha: doc_id: 321594 cord_uid: x5wv9p7n file: cache/cord-321651-7e8dwcur.json key: cord-321651-7e8dwcur authors: Jazieh, Abdul-Rahman; Al Hadab, Abdulrahman; Al Olayan, Ashwaq; AlHejazi, Ayman; Al Safi, Faisal; Al Qarni, Abullah; Farooqui, Faisal; Al Mutairi, Nashmia; Alenazi, Thamer H. title: Managing Oncology Services During a Major Coronavirus Outbreak: Lessons From the Saudi Arabia Experience date: 2020-03-27 journal: JCO Glob Oncol DOI: 10.1200/go.20.00063 sha: doc_id: 321651 cord_uid: 7e8dwcur file: cache/cord-321237-ynhdii60.json key: cord-321237-ynhdii60 authors: Shahroor, S. H.; Sarouf, Y.; Oz-Ari, L.; Gilad, M.; k, J.; Leshem, N.; Z, N.; Naor, M.; B, A.; L, R. title: Adaptive split ventilator system enables parallel ventilation, individual monitoring and ventilation pressures control for each lung simulators date: 2020-04-17 journal: nan DOI: 10.1101/2020.04.13.20064170 sha: doc_id: 321237 cord_uid: ynhdii60 file: cache/cord-321983-566pbuic.json key: cord-321983-566pbuic authors: Liu, Wei; Tao, Zhao-Wu; Wang, Lei; Yuan, Ming-Li; Liu, Kui; Zhou, Ling; Wei, Shuang; Deng, Yan; Liu, Jing; Liu, Hui-Guo; Ming, Yang; Yi, Hu title: Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease date: 2020-02-28 journal: Chin Med J (Engl) DOI: 10.1097/cm9.0000000000000775 sha: doc_id: 321983 cord_uid: 566pbuic file: cache/cord-321788-z2y1ywdq.json key: cord-321788-z2y1ywdq authors: Dong, J.; Wu, L.; Jin, Q.; Chen, J.; He, J. title: Chest CT Scan of Hospitalized Patients with COVID-19: A Case-Control Study date: 2020-04-11 journal: nan DOI: 10.1101/2020.04.07.20056762 sha: doc_id: 321788 cord_uid: z2y1ywdq file: cache/cord-321552-lsz1onrj.json key: cord-321552-lsz1onrj authors: Membrilla, Javier A.; de Lorenzo, Íñigo; Sastre, María; Díaz de Terán, Javier title: Headache as a Cardinal Symptom of Coronavirus Disease 2019: A Cross‐Sectional Study date: 2020-09-28 journal: Headache DOI: 10.1111/head.13967 sha: doc_id: 321552 cord_uid: lsz1onrj file: cache/cord-320930-9yiu0080.json key: cord-320930-9yiu0080 authors: Liu, Zeming; Li, Jinpeng; Huang, Jianglong; Guo, Liang; Gao, Rongfen; Luo, Kuan; Zeng, Guang; Zhang, Tingbao; Yi, Meilin; Huang, Yihui; Chen, Jincao; Yang, Yibin; Wu, Xiaohui title: Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan date: 2020-07-14 journal: Front Endocrinol (Lausanne) DOI: 10.3389/fendo.2020.00478 sha: doc_id: 320930 cord_uid: 9yiu0080 file: cache/cord-321472-n4nnmlv1.json key: cord-321472-n4nnmlv1 authors: Oliveira, E.; Parikh, A.; Lopez-Ruiz, A.; Carrillo, M.; Goldberg, J.; Cearras, M.; Fernainy, K.; Andersen, S.; Mercado, L.; Guan, J.; Zafar, H.; Louzon, P.; Carr, A.; Baloch, N.; Pratley, R.; Silvestry, S.; Hsu, V.; Sniffen, J.; Herrera, V.; Finkler, N. title: ICU Outcomes and Survival in Patients with Severe COVID-19 in the Largest Health Care System in Central Florida date: 2020-08-31 journal: nan DOI: 10.1101/2020.08.25.20181909 sha: doc_id: 321472 cord_uid: n4nnmlv1 file: cache/cord-322009-0cwljo0c.json key: cord-322009-0cwljo0c authors: Ma, Ling; Wang, Wenjing; Le Grange, Jehane Michael; Wang, Xiaorong; Du, Shuaixian; Li, Chen; Wei, Jia; Zhang, Jin-Nong title: Coinfection of SARS-CoV-2 and Other Respiratory Pathogens date: 2020-08-26 journal: Infect Drug Resist DOI: 10.2147/idr.s267238 sha: doc_id: 322009 cord_uid: 0cwljo0c file: cache/cord-322063-96suqyfg.json key: cord-322063-96suqyfg authors: Kampmeier, Stefanie; Tönnies, Hauke; Correa-Martinez, Carlos L.; Mellmann, Alexander; Schwierzeck, Vera title: A nosocomial cluster of vancomycin resistant enterococci among COVID-19 patients in an intensive care unit date: 2020-09-22 journal: Antimicrob Resist Infect Control DOI: 10.1186/s13756-020-00820-8 sha: doc_id: 322063 cord_uid: 96suqyfg file: cache/cord-322054-whjisspt.json key: cord-322054-whjisspt authors: Zhang, S.; Lu, X.; Cao, Y.; Li, Y.; Li, C.; Zhang, W. title: Concerns about disease management and psychological stress in SAPHO patients during the COVID-19 epidemic date: 2020-05-11 journal: nan DOI: 10.1101/2020.05.07.20084087 sha: doc_id: 322054 cord_uid: whjisspt file: cache/cord-321837-0r86qxz1.json key: cord-321837-0r86qxz1 authors: Zimmerman, Peta-Anne; Mason, Matt; Elder, Elizabeth title: A healthy degree of suspicion: A discussion of the implementation of transmission based precautions in the emergency department date: 2016-08-31 journal: Australasian Emergency Nursing Journal DOI: 10.1016/j.aenj.2016.03.001 sha: doc_id: 321837 cord_uid: 0r86qxz1 file: cache/cord-322066-m8dphaml.json key: cord-322066-m8dphaml authors: Kutscher, Eric; Kladney, Mat title: Primary Care Providers: Discuss COVID-19-Related Goals of Care with Your Vulnerable Patients Now date: 2020-05-06 journal: J Gen Intern Med DOI: 10.1007/s11606-020-05862-7 sha: doc_id: 322066 cord_uid: m8dphaml file: cache/cord-321801-w66v5kzh.json key: cord-321801-w66v5kzh authors: Grabala, Jolanta; Grabala, Michał; Onichimowski, Dariusz; Grabala, Paweł title: Possibilities of using ultrasound for diagnosis of invasive pulmonary mucormycosis – A case study date: 2017-08-31 journal: Polish Annals of Medicine DOI: 10.1016/j.poamed.2016.11.004 sha: doc_id: 321801 cord_uid: w66v5kzh file: cache/cord-322052-zsbisk3b.json key: cord-322052-zsbisk3b authors: Bohórquez-Rivero, José; García-Ballestas, Ezequiel; Moscote-Salazar, Luis Rafael title: Letter to the Editor: Humanization of Neurosurgery: Incorporation of a New Concept in Times of COVID-19 date: 2020-08-24 journal: World Neurosurg DOI: 10.1016/j.wneu.2020.06.142 sha: doc_id: 322052 cord_uid: zsbisk3b file: cache/cord-321784-nubu5fuz.json key: cord-321784-nubu5fuz authors: Salazar, E.; Perez, K. K.; Ashraf, M.; Chen, J.; Castillo, B.; Christensen, P. A.; Eubank, T.; Bernard, D. W.; Eagar, T. N.; Long, S. W.; Subedi, S.; Olsen, R. J.; Leveque, C.; Schwartz, M. R.; Dey, M.; Chavez-East, C.; Rogers, J.; Shehabeldin, A.; Joseph, D.; Williams, G.; Thomas, K.; Masud, F.; Talley, C.; Dlouhy, K. G.; Lopez, B. V.; Hampton, C.; Lavinder, J.; Gollihar, J. D.; Maranhao, A. C.; Ippolito, G. C.; Saavedra, M. O.; Cantu, C. C.; Yerramilli, P.; Pruitt, L.; Musser, J. M. title: Treatment of COVID-19 Patients with Convalescent Plasma in Houston, Texas date: 2020-05-13 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.05.08.20095471 sha: doc_id: 321784 cord_uid: nubu5fuz file: cache/cord-322394-b18fv3r3.json key: cord-322394-b18fv3r3 authors: Eichberg, Daniel G; Basil, Gregory W; Di, Long; Shah, Ashish H; Luther, Evan M; Lu, Victor M; Perez-Dickens, Maggy; Komotar, Ricardo J; Levi, Allan D; Ivan, Michael E title: Telemedicine in Neurosurgery: Lessons Learned from a Systematic Review of the Literature for the COVID-19 Era and Beyond date: 2020-07-20 journal: Neurosurgery DOI: 10.1093/neuros/nyaa306 sha: doc_id: 322394 cord_uid: b18fv3r3 file: cache/cord-322322-woz6lwdu.json key: cord-322322-woz6lwdu authors: Marcum, Michelle; Kurtzweil, Nicky; Vollmer, Christine; Schmid, Lisa; Vollmer, Ashley; Kastl, Alison; Acker, Kelly; Gulati, Shuchi; Grover, Punita; Herzog, Thomas J.; Ahmad, Syed A.; Sohal, Davendra; Wise‐Draper, Trisha M. title: COVID‐19 pandemic and impact on cancer clinical trials: An academic medical center perspective date: 2020-07-10 journal: Cancer Med DOI: 10.1002/cam4.3292 sha: doc_id: 322322 cord_uid: woz6lwdu file: cache/cord-322439-86dojc70.json key: cord-322439-86dojc70 authors: Celarier, Thomas; Lafaie, Ludovic; Goethals, Luc; Barth, Nathalie; Gramont, Baptiste; Ojardias, Etienne; Bongue, Bienvenu title: Covid-19: Adapting the geriatric organisations to respond to the pandemic date: 2020-06-11 journal: Respir Med Res DOI: 10.1016/j.resmer.2020.100774 sha: doc_id: 322439 cord_uid: 86dojc70 file: cache/cord-322259-khknne8s.json key: cord-322259-khknne8s authors: de Roquetaillade, C.; Chousterman, B.G.; Tomasoni, D.; Zeitouni, M.; Houdart, E.; Guedon, A.; Reiner, P.; Bordier, R.; Gayat, E.; Montalescot, G.; Metra, M.; Mebazaa, A. title: Unusual arterial thrombotic events in Covid-19 patients date: 2020-09-10 journal: Int J Cardiol DOI: 10.1016/j.ijcard.2020.08.103 sha: doc_id: 322259 cord_uid: khknne8s file: cache/cord-322102-4fi0y96f.json key: cord-322102-4fi0y96f authors: Zimmermann, Matthias; Nkenke, Emeka title: Approaches to the management of patients in oral and maxillofacial surgery during COVID-19 pandemic date: 2020-04-04 journal: J Craniomaxillofac Surg DOI: 10.1016/j.jcms.2020.03.011 sha: doc_id: 322102 cord_uid: 4fi0y96f file: cache/cord-322104-f1dukpso.json key: cord-322104-f1dukpso authors: Niederman, M.S. title: PNEUMONIA | Community Acquired Pneumonia, Bacterial and Other Common Pathogens date: 2006-05-13 journal: Encyclopedia of Respiratory Medicine DOI: 10.1016/b0-12-370879-6/00310-0 sha: doc_id: 322104 cord_uid: f1dukpso file: cache/cord-322534-eikz07zz.json key: cord-322534-eikz07zz authors: Allahyari, Abolghasem; Rahimi, Hossein; Khadem-Rezaiyan, Majid; Mozaheb, Zahra; Seddigh-Shamsi, Mohsen; Bary, Alireza; Kamandi, Mostafa; Azimi, Sajad Ataei; HasanAbadi, Saeed Eslami; Noferesti, Alireza; Shariatmaghani, Somayeh Sadat; Rafatpanah, Houshang; Khatami, Shohreh; Imani, Afshin Jabbar; Mortazi, Hassan; Nodeh, Mohammad Moeini title: Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structured summary of a study protocol for a randomised controlled trial date: 2020-06-26 journal: Trials DOI: 10.1186/s13063-020-04485-x sha: doc_id: 322534 cord_uid: eikz07zz file: cache/cord-322497-hdy3va8e.json key: cord-322497-hdy3va8e authors: LUBANSU, Alphonse; ASSAMADI, Mouhssine; BARRIT, Sami; DEMBOUR, Victoria; YAO, Gedeon; HADWE, Salim EL.; WITTE, Olivier DE. title: COVID-19 impact on neurosurgical practice: lockdown attitude and experience of a European academic center. date: 2020-09-03 journal: World Neurosurg DOI: 10.1016/j.wneu.2020.08.168 sha: doc_id: 322497 cord_uid: hdy3va8e file: cache/cord-321697-yua3apfi.json key: cord-321697-yua3apfi authors: Crigna, Adriana Torres; Samec, Marek; Koklesova, Lenka; Liskova, Alena; Giordano, Frank A.; Kubatka, Peter; Golubnitschaja, Olga title: Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope? date: 2020-10-29 journal: EPMA J DOI: 10.1007/s13167-020-00226-x sha: doc_id: 321697 cord_uid: yua3apfi file: cache/cord-322552-95bj65qf.json key: cord-322552-95bj65qf authors: Sang, Charlie Joseph; Heindl, Brittain; Von Mering, Gregory; Brott, Brigitta; Kopf, Robert S.; Rajapreyar, Indranee title: ST Elevations in the Era of COVID-19 date: 2020-08-06 journal: Case Rep Cardiol DOI: 10.1155/2020/8845627 sha: doc_id: 322552 cord_uid: 95bj65qf file: cache/cord-322746-28igib4l.json key: cord-322746-28igib4l authors: Gosche, John R.; Vick, Laura title: Acute, subacute, and chronic cervical lymphadenitis in children date: 2007-06-06 journal: Semin Pediatr Surg DOI: 10.1053/j.sempedsurg.2006.02.007 sha: doc_id: 322746 cord_uid: 28igib4l file: cache/cord-322867-1yxxe5d3.json key: cord-322867-1yxxe5d3 authors: Hartman, William R; Hess, Aaron S; Connor, Joseph P title: Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest date: 2020-07-14 journal: Res Sq DOI: 10.21203/rs.3.rs-39447/v1 sha: doc_id: 322867 cord_uid: 1yxxe5d3 file: cache/cord-322590-twnlaq24.json key: cord-322590-twnlaq24 authors: Hoyer, Carolin; Grassl, Niklas; Bail, Kathrin; Stein, Patrick; Ebert, Anne; Platten, Michael; Szabo, Kristina title: Changes in Demographic and Diagnostic Spectra of Patients with Neurological Symptoms Presenting to an Emergency Department During the COVID-19 Pandemic: A Retrospective Cohort Study date: 2020-09-30 journal: Neuropsychiatr Dis Treat DOI: 10.2147/ndt.s273913 sha: doc_id: 322590 cord_uid: twnlaq24 file: cache/cord-322868-o3r0y6bz.json key: cord-322868-o3r0y6bz authors: Williams, E. J.; Mair, L.; de Silva, T. I.; Green, D. J.; House, P.; Cawthron, K.; Gillies, C.; Wigfull, J.; Parsons, H.; Partridge, D. G. title: Routine measurement of serum procalcitonin allows antibiotics to be safely withheld in patients admitted to hospital with SARS-CoV-2 infection. date: 2020-07-02 journal: nan DOI: 10.1101/2020.06.29.20136572 sha: doc_id: 322868 cord_uid: o3r0y6bz file: cache/cord-322448-s04e6po9.json key: cord-322448-s04e6po9 authors: Gadsby, Naomi J.; Russell, Clark D.; McHugh, Martin P.; Mark, Harriet; Conway Morris, Andrew; Laurenson, Ian F.; Hill, Adam T.; Templeton, Kate E. title: Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia date: 2016-04-01 journal: Clin Infect Dis DOI: 10.1093/cid/civ1214 sha: doc_id: 322448 cord_uid: s04e6po9 file: cache/cord-322663-a58e6pp8.json key: cord-322663-a58e6pp8 authors: Giacomelli, Andrea; Ridolfo, Anna Lisa; Milazzo, Laura; Oreni, Letizia; Bernacchia, Dario; Siano, Matteo; Bonazzetti, Cecilia; Covizzi, Alice; Schiuma, Marco; Passerini, Matteo; Piscaglia, Marco; Coen, Massimo; Gubertini, Guido; Rizzardini, Giuliano; Cogliati, Chiara; Brambilla, Anna Maria; Colombo, Riccardo; Castelli, Antonio; Rech, Roberto; Riva, Agostino; Torre, Alessandro; Meroni, Luca; Rusconi, Stefano; Antinor, Spinello; Galli, Massimo title: 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study date: 2020-05-22 journal: Pharmacol Res DOI: 10.1016/j.phrs.2020.104931 sha: doc_id: 322663 cord_uid: a58e6pp8 file: cache/cord-322799-opf1qwgl.json key: cord-322799-opf1qwgl authors: Hiremath, Channabasavaraj Shivalingaiah; Yadava, Om Prakash; Meharwal, Zile Singh; Iyer, Krishna Subramony; Velayudhan, Bashi title: IACTS guidelines: practice of cardiovascular and thoracic surgery in the COVID-19 era date: 2020-08-11 journal: Indian J Thorac Cardiovasc Surg DOI: 10.1007/s12055-020-01016-w sha: doc_id: 322799 cord_uid: opf1qwgl file: cache/cord-322957-clf8f90t.json key: cord-322957-clf8f90t authors: Crespo, Javier; Andrade, Raúl; Parras, Fernando Alberca de las; Balaguer, Francesc; Acosta, Manuel Barreiro-de; Bujanda, Luís; Gutiérrez, Ana; Jorquera, Francisco; Iglesias-García, Julio; Sánchez-Yagüe, Andrés; Calleja, José Luis title: Resumption of activity in gastroenterology departments. Recommendations by SEPD, AEEH, GETECCU and AEG date: 2020-04-28 journal: nan DOI: 10.1016/j.gastre.2020.04.001 sha: doc_id: 322957 cord_uid: clf8f90t file: cache/cord-322990-q07yy5k8.json key: cord-322990-q07yy5k8 authors: Garutti, Mattia; Cortiula, Francesco; Puglisi, Fabio title: Seven Shades of Black Thoughts: COVID-19 and Its Psychological Consequences on Cancer Patients date: 2020-07-10 journal: Front Oncol DOI: 10.3389/fonc.2020.01357 sha: doc_id: 322990 cord_uid: q07yy5k8 file: cache/cord-323133-gdg50omp.json key: cord-323133-gdg50omp authors: Buzatto, G. P.; Tamashiro, E.; Proenca-Modena, J. L.; Saturno, T. H.; Prates, M. C.; Gagliardi, T. B.; Carenzi, L. R.; Massuda, E. T.; Hyppolito, M. A.; Valera, F. C. P.; Arruda, E.; Anselmo-Lima, W. T. title: The pathogens profile in children with otitis media with effusion and adenoid hypertrophy date: 2017-02-23 journal: PLoS One DOI: 10.1371/journal.pone.0171049 sha: doc_id: 323133 cord_uid: gdg50omp file: cache/cord-323024-blc3mnbj.json key: cord-323024-blc3mnbj authors: Bernard-Valnet, R.; Perriot, S.; Canales, M.; Pizzarotti, B.; Caranzano, L.; Castro-Jimenez, M.; Epiney, J.-B.; Vijiala, S.; Salvioni Chiabotti, P.; Anichini, A.; Salerno, A.; Jaton, K.; Vaucher, J.; Perreau, M.; Greub, G.; Pantaleo, G.; Du Pasquier, R. title: CSF of SARS-CoV-2 patients with neurological syndromes reveals hints to understand pathophysiology date: 2020-11-04 journal: nan DOI: 10.1101/2020.11.01.20217497 sha: doc_id: 323024 cord_uid: blc3mnbj file: cache/cord-322893-av8hj005.json key: cord-322893-av8hj005 authors: MacKoul, Paul; Danilyants, Natalya; Touchan, Faraj; van der Does, Louise Q.; Haworth, Leah R.; Kazi, Nilofar title: Laparoscopic-assisted myomectomy with uterine artery occlusion at a freestanding ambulatory surgery center: a case series date: 2020-06-16 journal: Gynecol Surg DOI: 10.1186/s10397-020-01075-2 sha: doc_id: 322893 cord_uid: av8hj005 file: cache/cord-323092-j2u0ny2u.json key: cord-323092-j2u0ny2u authors: Crosby, James C.; Heimann, Matthew A.; Burleson, Samuel L.; Anzalone, Brendan C.; Swanson, Jonathan F.; Wallace, Douglas W.; Greene, Christopher J. title: COVID‐19: A review of therapeutics under investigation date: 2020-04-19 journal: J Am Coll Emerg Physicians Open DOI: 10.1002/emp2.12081 sha: doc_id: 323092 cord_uid: j2u0ny2u file: cache/cord-323180-3ih0i81s.json key: cord-323180-3ih0i81s authors: Pardo, Emmanuel; Constantin, Jean-Michel; Bonnet, Francis; Verdonk, Franck title: Nutritional support for critically ill patients with COVID-19: New strategy for a new disease? date: 2020-10-12 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.10.002 sha: doc_id: 323180 cord_uid: 3ih0i81s file: cache/cord-323225-ou7pppum.json key: cord-323225-ou7pppum authors: Mondal, R. N.; Razzak Sarker, M. A.; Das, A.; Ahsan, M. A. K.; Jahan, S. M. S.; Sultana, A.; Sultana, J.; Rani, M. title: Socio-demographic, clinical, hospital admission and oxygen requirement characteristics of COVID-19 patients of Bangladesh date: 2020-08-16 journal: nan DOI: 10.1101/2020.08.14.20175018 sha: doc_id: 323225 cord_uid: ou7pppum file: cache/cord-323255-elwfiima.json key: cord-323255-elwfiima authors: Huijskens, E. G. W.; Smit, L. A. M.; Rossen, J. W. A.; Heederik, D.; Koopmans, M. title: Evaluation of Patients with Community‐Acquired Pneumonia Caused by Zoonotic Pathogens in an Area with a High Density of Animal Farms date: 2015-07-27 journal: Zoonoses Public Health DOI: 10.1111/zph.12218 sha: doc_id: 323255 cord_uid: elwfiima file: cache/cord-322861-q7uk6rdp.json key: cord-322861-q7uk6rdp authors: Zanon, Ezio; Pasca, Samantha; Campello, Elena; Spiezia, Luca; Vettor, Roberto; Simioni, Paolo title: How haemophilia A impacts severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) treatment: a case report date: 2020-07-16 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02227-z sha: doc_id: 322861 cord_uid: q7uk6rdp file: cache/cord-323446-w2ci1bfr.json key: cord-323446-w2ci1bfr authors: Pan, Feng; Ye, Tianhe; Sun, Peng; Gui, Shan; Liang, Bo; Li, Lingli; Zheng, Dandan; Wang, Jiazheng; Hesketh, Richard L.; Yang, Lian; Zheng, Chuansheng title: Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia date: 2020-02-13 journal: Radiology DOI: 10.1148/radiol.2020200370 sha: doc_id: 323446 cord_uid: w2ci1bfr file: cache/cord-323314-y3k9dntf.json key: cord-323314-y3k9dntf authors: Aggarwal, Sandeep; Mahawar, Kamal; Khaitan, Manish; Raj, Praveen; Wadhawan, Randeep; Dukkipati, NandaKishore; Kular, Kuldeepak S; Prasad, Arun; Bhasker, Aparna Govil; Soni, Vandana; Madhok, Brijesh; Baig, Sarfaraz; Palaniappan, Raj; Shivaram, H. V.; Goel, Deep; Bindal, Vivek; Saggu, Sukhvinder; Shrivastava, Rajesh; Shah, Sumeet; Dhorepatil, Shrihari; Khullar, Rajesh title: Obesity and Metabolic Surgery Society of India (OSSI) Recommendations for Bariatric and Metabolic Surgery Practice During the COVID-19 Pandemic date: 2020-08-22 journal: Obes Surg DOI: 10.1007/s11695-020-04940-3 sha: doc_id: 323314 cord_uid: y3k9dntf file: cache/cord-323293-4gmnkg09.json key: cord-323293-4gmnkg09 authors: Sobhani, Navid; D’Angelo, Alberto; Wang, Xu; Young, Ken H.; Generali, Daniele; Li, Yong title: Mutant p53 as an Antigen in Cancer Immunotherapy date: 2020-06-08 journal: Int J Mol Sci DOI: 10.3390/ijms21114087 sha: doc_id: 323293 cord_uid: 4gmnkg09 file: cache/cord-323470-lpeeugdf.json key: cord-323470-lpeeugdf authors: Ates, Omer Faruk; Taydas, Onur; Dheir, Hamad title: Thorax magnetic resonance imaging findings in patients with coronavirus disease (COVID-19) date: 2020-08-15 journal: Acad Radiol DOI: 10.1016/j.acra.2020.08.009 sha: doc_id: 323470 cord_uid: lpeeugdf file: cache/cord-323463-osf6t7cw.json key: cord-323463-osf6t7cw authors: Cercenado, Emilia; Garau, Javier; Almirante, Benito; Ramón Azanza, José; Cantón, Rafael; Cisterna, Ramón; María Eiros, José; Fariñas, Carmen; Fortún, Jesús; Gudiol, Francisco; Mensa, José; Pachón, Jerónimo; Pascual, Álvaro; Luis Pérez, José; Rodríguez, Alejandro; Sánchez, Miguel; Vila, Jordi title: Update on bacterial pathogens: virulence and resistance date: 2008-04-30 journal: Enfermedades Infecciosas y Microbiología Clínica DOI: 10.1016/s0213-005x(08)76378-x sha: doc_id: 323463 cord_uid: osf6t7cw file: cache/cord-323538-9dlr6kqh.json key: cord-323538-9dlr6kqh authors: Malard, Florent; Genthon, Alexis; Brissot, Eolia; van de Wyngaert, Zoe; Marjanovic, Zora; Ikhlef, Souhila; Banet, Anne; Lapusan, Simona; Sestilli, Simona; Corre, Elise; Paviglianiti, Annalisa; Adaeva, Rosa; M.’Hammedi-Bouzina, Fella; Labopin, Myriam; Legrand, Ollivier; Dulery, Rémy; Mohty, Mohamad title: COVID-19 outcomes in patients with hematologic disease date: 2020-05-06 journal: Bone Marrow Transplant DOI: 10.1038/s41409-020-0931-4 sha: doc_id: 323538 cord_uid: 9dlr6kqh file: cache/cord-323647-q67fa0m3.json key: cord-323647-q67fa0m3 authors: Misra, Durga Prasanna; Gasparyan, Armen Yuri; Zimba, Olena title: Benefits and adverse effects of hydroxychloroquine, methotrexate and colchicine: searching for repurposable drug candidates date: 2020-09-02 journal: Rheumatol Int DOI: 10.1007/s00296-020-04694-2 sha: doc_id: 323647 cord_uid: q67fa0m3 file: cache/cord-323809-bocidwg4.json key: cord-323809-bocidwg4 authors: Patel, Dhwanil; Truong, Tiffany; Shah, Nikhil; Colbert, Gates B.; Thomas, Beje; Velez, Juan Carlos Q.; Lerma, Edgar V.; Hiremath, Swapnil title: COVID-19 EXTRAPULMONARY ILLNESS - The Impact of COVID-19 on Nephrology Care date: 2020-07-25 journal: Dis Mon DOI: 10.1016/j.disamonth.2020.101057 sha: doc_id: 323809 cord_uid: bocidwg4 file: cache/cord-323713-bc00vths.json key: cord-323713-bc00vths authors: Volpi, Stefano; Insalaco, Antonella; Caorsi, Roberta; Santori, Elettra; Messia, Virginia; Sacco, Oliviero; Terheggen-Lagro, Suzanne; Cardinale, Fabio; Scarselli, Alessia; Pastorino, Claudia; Moneta, Gianmarco; Cangemi, Giuliana; Passarelli, Chiara; Ricci, Margherita; Girosi, Donata; Derchi, Maria; Bocca, Paola; Diociaiuti, Andrea; El Hachem, May; Cancrini, Caterina; Tomà, Paolo; Granata, Claudio; Ravelli, Angelo; Candotti, Fabio; Picco, Paolo; DeBenedetti, Fabrizio; Gattorno, Marco title: Efficacy and Adverse Events During Janus Kinase Inhibitor Treatment of SAVI Syndrome date: 2019-05-29 journal: J Clin Immunol DOI: 10.1007/s10875-019-00645-0 sha: doc_id: 323713 cord_uid: bc00vths file: cache/cord-323273-q53wf6au.json key: cord-323273-q53wf6au authors: Olivia Li, Ji-Peng; Liu, Hanruo; Ting, Darren S.J.; Jeon, Sohee; Chan, R.V.Paul; Kim, Judy E.; Sim, Dawn A.; Thomas, Peter B.M.; Lin, Haotian; Chen, Youxin; Sakomoto, Taiji; Loewenstein, Anat; Lam, Dennis S.C.; Pasquale, Louis R.; Wong, Tien Y.; Lam, Linda A.; Ting, Daniel S.W. title: Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective date: 2020-09-06 journal: Prog Retin Eye Res DOI: 10.1016/j.preteyeres.2020.100900 sha: doc_id: 323273 cord_uid: q53wf6au file: cache/cord-323489-ro7kbnu3.json key: cord-323489-ro7kbnu3 authors: Arenas, María Dolores; Villar, Judit; González, Cristina; Cao, Higinio; Collado, Silvia; Barbosa, Francesc; Crespo, Marta; Horcajada, Juan Pablo; Pascual, Julio title: Protection of nephrology health professionals during the COVID-19 pandemic date: 2020-10-06 journal: nan DOI: 10.1016/j.nefroe.2020.06.018 sha: doc_id: 323489 cord_uid: ro7kbnu3 file: cache/cord-323582-7y8pt72r.json key: cord-323582-7y8pt72r authors: Ahamad, Martuza; Aktar, Sakifa; Rashed-Al-Mahfuz; Uddin, Shahadat; Lió, Pietro; Xu, Haoming; Summers, Matthew A.; Quinn, Julian M.W.; Moni, Mohammad Ali title: A Machine Learning Model to Identify Early Stage Symptoms of SARS-Cov-2 Infected Patients date: 2020-06-20 journal: Expert Syst Appl DOI: 10.1016/j.eswa.2020.113661 sha: doc_id: 323582 cord_uid: 7y8pt72r file: cache/cord-323910-lms3xw4k.json key: cord-323910-lms3xw4k authors: Putman, Michael; Chock, Yu Pei Eugenia; Tam, Herman; Kim, Alfred H.J.; Sattui, Sebastian E.; Berenbaum, Francis; Danila, Maria I.; Korsten, Peter; Sanchez‐Alvarez, Catalina; Sparks, Jeffrey A.; Coates, Laura C.; Palmerlee, Candace; Peirce, Andrea; Jayatilleke, Arundathi; Johnson, Sindhu R.; Kilian, Adam; Liew, Jean; Prokop, Larry J.; Murad, M. Hassan; Grainger, Rebecca; Wallace, Zachary S.; Duarte‐García, Alí title: Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐analysis date: 2020-08-02 journal: Arthritis Rheumatol DOI: 10.1002/art.41469 sha: doc_id: 323910 cord_uid: lms3xw4k file: cache/cord-323965-6mzzibj8.json key: cord-323965-6mzzibj8 authors: Kapoor, Krishan Mohan; Chatrath, Vandana; Boxley, Sarah Gillian; Nurlin, Iman; Snozzi, Philippe; Demosthenous, Nestor; Belo, Victoria; Chan, Wai Man; Kanaris, Nicole; Kapoor, Puneet title: COVID‐19 Pandemic: Consensus Guidelines for Preferred Practices in an Aesthetic Clinic date: 2020-05-16 journal: Dermatol Ther DOI: 10.1111/dth.13597 sha: doc_id: 323965 cord_uid: 6mzzibj8 file: cache/cord-323705-n2rec4i8.json key: cord-323705-n2rec4i8 authors: Varatharaj, Aravinthan; Thomas, Naomi; Ellul, Mark A; Davies, Nicholas W S; Pollak, Thomas A; Tenorio, Elizabeth L; Sultan, Mustafa; Easton, Ava; Breen, Gerome; Zandi, Michael; Coles, Jonathan P; Manji, Hadi; Al-Shahi Salman, Rustam; Menon, David K; Nicholson, Timothy R; Benjamin, Laura A; Carson, Alan; Smith, Craig; Turner, Martin R; Solomon, Tom; Kneen, Rachel; Pett, Sarah L; Galea, Ian; Thomas, Rhys H; Michael, Benedict D title: Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study date: 2020-06-25 journal: Lancet Psychiatry DOI: 10.1016/s2215-0366(20)30287-x sha: doc_id: 323705 cord_uid: n2rec4i8 file: cache/cord-323831-1qadv7r1.json key: cord-323831-1qadv7r1 authors: Coleman, H; Sutherland, J; Calder, N title: Severe acute respiratory syndrome coronavirus-2 in post-laryngectomy patients: case series of four patients date: 2020-06-23 journal: The Journal of laryngology and otology DOI: 10.1017/s0022215120001310 sha: doc_id: 323831 cord_uid: 1qadv7r1 file: cache/cord-323906-ro078y52.json key: cord-323906-ro078y52 authors: Sardu, Celestino; Marfella, Raffaele; Maggi, Paolo; Messina, Vincenzo; Cirillo, Paolo; Codella, Vinicio; Gambardella, Jessica; Sardu, Antonio; Gatta, Gianluca; Santulli, Gaetano; Paolisso, Giuseppe title: Implications of AB0 blood group in hypertensive patients with covid-19 date: 2020-08-14 journal: BMC Cardiovasc Disord DOI: 10.1186/s12872-020-01658-z sha: doc_id: 323906 cord_uid: ro078y52 file: cache/cord-323787-9lq8rkih.json key: cord-323787-9lq8rkih authors: Bösch, Florian; Börner, Nikolaus; Kemmner, Stephan; Lampert, Christopher; Jacob, Sven; Koliogiannis, Dionysios; Stangl, Manfred; Michel, Sebastian; Kneidinger, Nikolaus; Schneider, Christian; Fischereder, Michael; Irlbeck, Michael; Denk, Gerald; Werner, Jens; Angele, Martin K.; Guba, Markus O. title: Attenuated early inflammatory response in solid organ recipients with COVID‐19 date: 2020-06-26 journal: Clin Transplant DOI: 10.1111/ctr.14027 sha: doc_id: 323787 cord_uid: 9lq8rkih file: cache/cord-323980-rcyjthze.json key: cord-323980-rcyjthze authors: Willems, Laurent M.; Balcik, Yunus; Noda, Anna H.; Siebenbrodt, Kai; Leimeister, Sina; McCoy, Jeannie; Kienitz, Ricardo; Kiyose, Makoto; Reinecke, Raphael; Schäfer, Jan-Hendrik; Zöllner, Johann Philipp; Bauer, Sebastian; Rosenow, Felix; Strzelczyk, Adam title: SARS-CoV-2-related rapid reorganization of an epilepsy outpatient clinic from personal appointments to telemedicine services: A German single-center experience date: 2020-10-06 journal: Epilepsy Behav DOI: 10.1016/j.yebeh.2020.107483 sha: doc_id: 323980 cord_uid: rcyjthze file: cache/cord-323816-3m1iu9j2.json key: cord-323816-3m1iu9j2 authors: Singh, Awadhesh Kumar; Misra, Anoop title: Impact of COVID-19 and comorbidities on health and economics: Focus on developing countries and India date: 2020-08-27 journal: Diabetes Metab Syndr DOI: 10.1016/j.dsx.2020.08.032 sha: doc_id: 323816 cord_uid: 3m1iu9j2 file: cache/cord-323761-9m177ozm.json key: cord-323761-9m177ozm authors: Wang, Huijie; Li, Na; Huang, Huaqiong title: Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety date: 2020-02-22 journal: Can Respir J DOI: 10.1155/2020/9046842 sha: doc_id: 323761 cord_uid: 9m177ozm file: cache/cord-323913-v32c2vda.json key: cord-323913-v32c2vda authors: Istúriz, Raul E.; Torres, Jaime; Besso, José title: Global Distribution of Infectious Diseases Requiring Intensive Care date: 2006-07-31 journal: Critical Care Clinics DOI: 10.1016/j.ccc.2006.03.004 sha: doc_id: 323913 cord_uid: v32c2vda file: cache/cord-324175-5c4ijkpm.json key: cord-324175-5c4ijkpm authors: Kassas, Mohamed El; Abdelkader, Haytham; Medhat, Mohammed A. title: COVID-19 in Egypt: Through Crisis to Adaptation; a gastroenterologist’s Perspective date: 2020-07-19 journal: Arab J Gastroenterol DOI: 10.1016/j.ajg.2020.07.004 sha: doc_id: 324175 cord_uid: 5c4ijkpm file: cache/cord-324041-lqokztor.json key: cord-324041-lqokztor authors: Saussez, Sven; Lechien, Jerome R.; Hopkins, Claire title: Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered date: 2020-09-09 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06285-0 sha: doc_id: 324041 cord_uid: lqokztor file: cache/cord-324007-hapzf0fl.json key: cord-324007-hapzf0fl authors: McGeer, Allison J. title: Diagnostic Testing or Empirical Therapy for Patients Hospitalized with Suspected Influenza: What to Do? date: 2009-01-01 journal: Clin Infect Dis DOI: 10.1086/591852 sha: doc_id: 324007 cord_uid: hapzf0fl file: cache/cord-324669-qca0uwxo.json key: cord-324669-qca0uwxo authors: Radermecker, Coraline; Detrembleur, Nancy; Guiot, Julien; Cavalier, Etienne; Henket, Monique; d’Emal, Céline; Vanwinge, Céline; Cataldo, Didier; Oury, Cécile; Delvenne, Philippe; Marichal, Thomas title: Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19 date: 2020-09-14 journal: J Exp Med DOI: 10.1084/jem.20201012 sha: doc_id: 324669 cord_uid: qca0uwxo file: cache/cord-324666-fvk72o0p.json key: cord-324666-fvk72o0p authors: Alharbi, Musa; Mobark, Nahla Ali; Balbaid, Ali Abdullah O.; Alanazi, Fatmah A.; Aljabarat, Wael abdel Rahman; Bakhsh, Eman A.; Ramkissoon, Shakti H.; Abedalthagafi, Malak title: Regression of ETV6-NTRK3 Infantile Glioblastoma After First-Line Treatment With Larotrectinib date: 2020-06-30 journal: JCO Precis Oncol DOI: 10.1200/po.20.00017 sha: doc_id: 324666 cord_uid: fvk72o0p file: cache/cord-324159-jv3lknl8.json key: cord-324159-jv3lknl8 authors: Ashraf, Muddasir; Sajed, Sulaiman title: Acute Stroke in a Young Patient With Coronavirus Disease 2019 in the Presence of Patent Foramen Ovale date: 2020-09-03 journal: Cureus DOI: 10.7759/cureus.10233 sha: doc_id: 324159 cord_uid: jv3lknl8 file: cache/cord-324232-nupi7f72.json key: cord-324232-nupi7f72 authors: Villar, Jesús; Confalonieri, Marco; Pastores, Stephen M.; Meduri, G. Umberto title: Rationale for Prolonged Corticosteroid Treatment in the Acute Respiratory Distress Syndrome Caused by Coronavirus Disease 2019 date: 2020-04-29 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000111 sha: doc_id: 324232 cord_uid: nupi7f72 file: cache/cord-324245-cfiekxr4.json key: cord-324245-cfiekxr4 authors: Giorgi-Pierfranceschi, Matteo; Paoletti, Oriana; Pan, Angelo; De Gennaro, Fabio; Nardecchia, Anna Laura; Morandini, Rossella; Dellanoce, Claudia; Lombi, Samuele; Tala, Maurizio; Cancelli, Vanessa; Zambelli, Silvia; Bosio, Giancarlo; Romanini, Laura; Testa, Sophie title: Prevalence of asymptomatic deep vein thrombosis in patients hospitalized with SARS-CoV-2 pneumonia: a cross-sectional study date: 2020-08-25 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02472-3 sha: doc_id: 324245 cord_uid: cfiekxr4 file: cache/cord-324060-vvexfg1c.json key: cord-324060-vvexfg1c authors: Bogdanos, Dimitrios P.; Daniil, Zoi; Zakynthinos, Epaminondas; Gourgoulianis, Konstantinos; Sakkas, Lazaros I. title: When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients? date: 2020-03-31 journal: Mediterr J Rheumatol DOI: 10.31138/mjr.31.1.94 sha: doc_id: 324060 cord_uid: vvexfg1c file: cache/cord-324125-wau2xq0x.json key: cord-324125-wau2xq0x authors: Qiu, Chao; Yuan, Songhua; Tian, Di; Yang, Yu; Zhang, Anli; Chen, Qingguo; Wan, Yanmin; Song, Zhigang; He, Jing; Li, Liangzhu; Sun, Jun; Zhou, Mingzhe; Qiu, Chenli; Zhang, Zhiyong; Lu, Shuihua; Zhang, Xiaoyan; Hu, Yunwen; Xu, Jianqing title: Epidemiologic report and serologic findings for household contacts of three cases of influenza A (H7N9) virus infection date: 2013-12-16 journal: J Clin Virol DOI: 10.1016/j.jcv.2013.12.004 sha: doc_id: 324125 cord_uid: wau2xq0x file: cache/cord-324314-os1btxx1.json key: cord-324314-os1btxx1 authors: Park, Jaehyeon; Yea, Ji Woon; Park, Jae Won title: Departments of Radiation Oncology Must Prepare for COVID-19 Outbreak date: 2020-04-25 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.03.023 sha: doc_id: 324314 cord_uid: os1btxx1 file: cache/cord-324601-s3rgxtg6.json key: cord-324601-s3rgxtg6 authors: Mhimbira, F.; Hiza, H.; Mbuba, E.; Hella, J.; Kamwela, L.; Sasamalo, M.; Ticlla, M.; Said, K.; Mhalu, G.; Chiryamkubi, M.; Schindler, C.; Reither, K.; Gagneux, S.; Fenner, L. title: Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study date: 2019-01-31 journal: Clinical Microbiology and Infection DOI: 10.1016/j.cmi.2018.03.019 sha: doc_id: 324601 cord_uid: s3rgxtg6 file: cache/cord-324148-bllyruh8.json key: cord-324148-bllyruh8 authors: Loubet, Paul; Mathieu, Pauline; Lenzi, Nezha; Galtier, Florence; Lainé, Fabrice; Lesieur, Zineb; Vanhems, Philippe; Duval, Xavier; Postil, Deborah; Amour, Sélilah; Rogez, Sylvie; Lagathu, Gisèle; L'Honneur, Anne-Sophie; Foulongne, Vincent; Houhou, Nadhira; Lina, Bruno; Carrat, Fabrice; Launay, Odile title: Characteristics of human metapneumovirus infection in adults hospitalized for community-acquired influenza-like illness in France, 2012-2018: a retrospective observational study date: 2020-04-10 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2020.04.005 sha: doc_id: 324148 cord_uid: bllyruh8 file: cache/cord-323940-ubazgvov.json key: cord-323940-ubazgvov authors: Cafiero, Concetta; Re, Agnese; Micera, Alessandra; Palmirotta, Raffaele; Monaco, Delio; Romano, Francesca; Fabrizio, Claudia; Di Francia, Raffaele; Cacciamani, Andrea; Surico, Pier Luigi; D’Amato, Gerardo; Pisconti, Salvatore title: Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease date: 2020-10-13 journal: Pharmgenomics Pers Med DOI: 10.2147/pgpm.s270069 sha: doc_id: 323940 cord_uid: ubazgvov file: cache/cord-324859-0yuhb5dl.json key: cord-324859-0yuhb5dl authors: Mulchandani, Rubina; Lyngdoh, Tanica; Kakkar, Ashish Kumar title: Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis date: 2020-11-02 journal: Eur J Clin Invest DOI: 10.1111/eci.13429 sha: doc_id: 324859 cord_uid: 0yuhb5dl file: cache/cord-324843-r43u7sld.json key: cord-324843-r43u7sld authors: Kockuzu, Esra; Bayrakcı, Benan; Kesici, Selman; Cıtak, Agop; Karapınar, Bulent; Emeksiz, Serhat; Anıl, Ayşe Berna; Kendirli, Tanıl; Yukselmis, Ufuk; Sevketoglu, Esra; Paksu, Şukru; Kutlu, Onur; Agın, Hasan; Yıldızdas, Dincer; Keskin, Halil; Kalkan, Gokhan; Hasanoglu, Arzu; Yazıcı, Mutlu Uysal; Sık, Guntulu; Kılınc, Arda; Durak, Fatih; Perk, Oktay; Talip, Mey; Yener, Nazik; Uzuner, Selcuk title: Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey date: 2019-06-17 journal: Indian J Crit Care Med DOI: 10.5005/jp-journals-10071-23177 sha: doc_id: 324843 cord_uid: r43u7sld file: cache/cord-324880-s1oqkqef.json key: cord-324880-s1oqkqef authors: Xu, Lili; Gao, Hengmiao; Zeng, Jiansheng; Liu, Jun; Lu, Cong; Guan, Xiaolei; Qian, Suyun; Xie, Zhengde title: A fatal case associated with respiratory syncytial virus infection in a young child date: 2018-05-11 journal: BMC Infect Dis DOI: 10.1186/s12879-018-3123-8 sha: doc_id: 324880 cord_uid: s1oqkqef file: cache/cord-325201-yoy7kdli.json key: cord-325201-yoy7kdli authors: Timsit, Jean-François; Perner, Anders; Bakker, Jan; Bassetti, Matteo; Benoit, Dominique; Cecconi, Maurizio; Randall Curtis, J.; Doig, Gordon S.; Herridge, Margaret; Jaber, Samir; Joannidis, Michael; Papazian, Laurent; Peters, Mark J.; Singer, Pierre; Smith, Martin; Soares, Marcio; Torres, Antoni; Vieillard-Baron, Antoine; Citerio, Giuseppe; Azoulay, Elie title: Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics date: 2015-03-26 journal: Intensive Care Med DOI: 10.1007/s00134-015-3755-8 sha: doc_id: 325201 cord_uid: yoy7kdli file: cache/cord-324529-xbrdtxnz.json key: cord-324529-xbrdtxnz authors: Wang, Ming; Yan, Weiming; Qi, Weipeng; Wu, Di; Zhu, Lin; Li, Weina; Wang, Xiaojing; Ma, Ke; Ni, Ming; Xu, Dong; Wang, Hongwu; Chen, Guang; Yu, Haijing; Ding, Hongfang; Xing, Mingyou; Han, Meifang; Luo, Xiaoping; Chen, Tao; Guo, Wei; Xi, Dong; Ning, Qin title: Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China date: 2020-10-07 journal: Hepatol Int DOI: 10.1007/s12072-020-10075-5 sha: doc_id: 324529 cord_uid: xbrdtxnz file: cache/cord-324635-27q3nxte.json key: cord-324635-27q3nxte authors: Bouza, Emilio; Brenes, Francisco José; Domingo, Javier Díez; Bouza, José María Eiros; González, José; Gracia, Diego; González, Ricardo Juárez; Muñoz, Patricia; Torregrossa, Roberto Petidier; Casado, José Manuel Ribera; Cordero, Primitivo Ramos; Rovira, Eduardo Rodríguez; Torralba, María Eva Sáez; Rexach, José Antonio Serra; García, Javier Tovar; Bravo, Carlos Verdejo; Palomo, Esteban title: The situation of infection in the elderly in Spain: a multidisciplinary opinion document date: 2020-09-08 journal: Rev Esp Quimioter DOI: 10.37201/req/057.2020 sha: doc_id: 324635 cord_uid: 27q3nxte file: cache/cord-324809-16zvqizl.json key: cord-324809-16zvqizl authors: Mehta, Neil; Parikh, Neehar; Kelley, R Katie; Hameed, Bilal; Singal, Amit G. title: Surveillance and Monitoring of Hepatocellular Carcinoma During the COVID-19 Pandemic date: 2020-07-08 journal: Clin Gastroenterol Hepatol DOI: 10.1016/j.cgh.2020.06.072 sha: doc_id: 324809 cord_uid: 16zvqizl file: cache/cord-324619-y7gilopu.json key: cord-324619-y7gilopu authors: Alam, S.B.; Willows, Steven; Kulka, Marianna; Sandhu, Jagdeep K. title: Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system date: 2020-07-15 journal: Eur J Neurol DOI: 10.1111/ene.14442 sha: doc_id: 324619 cord_uid: y7gilopu file: cache/cord-325619-qmszgw66.json key: cord-325619-qmszgw66 authors: Ferrari, Andrea; Zecca, Marco; Rizzari, Carmelo; Porta, Fulvio; Provenzi, Massimo; Marinoni, Maddalena; Schumacher, Richard Fabian; Luksch, Roberto; Terenziani, Monica; Casanova, Michela; Spreafico, Filippo; Chiaravalli, Stefano; Compagno, Francesca; Bruni, Federica; Piccolo, Chiara; Bettini, Laura; D'Angiò, Mariella; Ferrari, Giulia Maria; Biondi, Andrea; Massimino, Maura; Balduzzi, Adriana title: Children with cancer in the time of COVID‐19: An 8‐week report from the six pediatric onco‐hematology centers in Lombardia, Italy date: 2020-05-26 journal: Pediatr Blood Cancer DOI: 10.1002/pbc.28410 sha: doc_id: 325619 cord_uid: qmszgw66 file: cache/cord-324944-ixh3ykrc.json key: cord-324944-ixh3ykrc authors: Mitsakakis, Konstantinos; D'Acremont, Valérie; Hin, Sebastian; von Stetten, Felix; Zengerle, Roland title: Diagnostic tools for tackling febrile illness and enhancing patient management date: 2018-12-05 journal: Microelectron Eng DOI: 10.1016/j.mee.2018.10.001 sha: doc_id: 324944 cord_uid: ixh3ykrc file: cache/cord-325234-skshcrh1.json key: cord-325234-skshcrh1 authors: Jin, Tingxu; Li, Jun; Yang, Jun; Li, Jiawei; Hong, Feng; Long, Hai; Deng, Qihong; Qin, Yong; Jiang, Jiajun; Zhou, Xuan; Song, Qian; Pan, Chunliu; Luo, Peng title: SARS-CoV-2 presented in the air of an intensive care unit (ICU) date: 2020-08-15 journal: Sustain Cities Soc DOI: 10.1016/j.scs.2020.102446 sha: doc_id: 325234 cord_uid: skshcrh1 file: cache/cord-325511-ot66dj3i.json key: cord-325511-ot66dj3i authors: Kim, Philip; Deer, Timothy title: Managing Intrathecal Drug Delivery Devices in a Global Pandemic date: 2020-05-13 journal: Neuromodulation DOI: 10.1111/ner.13176 sha: doc_id: 325511 cord_uid: ot66dj3i file: cache/cord-325628-pa3dkz2f.json key: cord-325628-pa3dkz2f authors: Wang, Jinsong; Kuang, Ming; Chen, Lingwu; Lian, Chong; Zhao, Lei; Wang, Shenming title: Strategy for treating vascular emergencies during the COVID-19 pandemic in China date: 2020-06-01 journal: J Vasc Surg DOI: 10.1016/j.jvs.2020.05.049 sha: doc_id: 325628 cord_uid: pa3dkz2f file: cache/cord-324918-36om8n2d.json key: cord-324918-36om8n2d authors: Guha, Chandana; Tong, Allison; Baumgart, Amanda; Scholes‐Robertson, Nicole; Isbel, Nicole; Kanellis, John; Campbell, Scott; Coates, Toby; Chadban, Steven title: Suspension and resumption of kidney transplant programs during the COVID‐19 pandemic: perspectives from patients, caregivers and potential living donors‐a qualitative study date: 2020-07-08 journal: Transpl Int DOI: 10.1111/tri.13697 sha: doc_id: 324918 cord_uid: 36om8n2d file: cache/cord-324810-92fosk3c.json key: cord-324810-92fosk3c authors: Sharma, Sat; Anthonisen, Nicholas title: Role of Antimicrobial Agents in the Management of Exacerbations of COPD date: 2012-08-23 journal: Treat Respir Med DOI: 10.2165/00151829-200504030-00001 sha: doc_id: 324810 cord_uid: 92fosk3c file: cache/cord-324679-rds8o5z4.json key: cord-324679-rds8o5z4 authors: Grant, Vincent J.; Wolff, Meg; Adler, Mark title: The Past, Present, and Future of Simulation-based Education for Pediatric Emergency Medicine date: 2016-05-26 journal: Clin Pediatr Emerg Med DOI: 10.1016/j.cpem.2016.05.005 sha: doc_id: 324679 cord_uid: rds8o5z4 file: cache/cord-325655-1fktmpbj.json key: cord-325655-1fktmpbj authors: Sun, Dan-Qin; Wang, Ting-Yao; Zheng, Kenneth I.; Targher, Giovanni; Byrne, Christopher D.; Chen, Yong-Ping; Zheng, Ming-Hua title: Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study date: 2020-05-26 journal: Nephron Clin Pract DOI: 10.1159/000508502 sha: doc_id: 325655 cord_uid: 1fktmpbj file: cache/cord-324798-qh0cxp10.json key: cord-324798-qh0cxp10 authors: Tanaka, Miho; Kodama, Satoshi; Lee, Ilhak; Huxtable, Richard; Chung, Yicheng title: Forgoing life-sustaining treatment – a comparative analysis of regulations in Japan, Korea, Taiwan, and England date: 2020-10-16 journal: BMC Med Ethics DOI: 10.1186/s12910-020-00535-w sha: doc_id: 324798 cord_uid: qh0cxp10 file: cache/cord-325307-agaau27o.json key: cord-325307-agaau27o authors: Giavedoni, Priscila; Podlipnik, Sebastián; Pericàs, Juan M.; Fuertes de Vega, Irene; García-Herrera, Adriana; Alós, Llúcia; Carrera, Cristina; Andreu-Febrer, Cristina; Sanz-Beltran, Judit; Riquelme-Mc Loughlin, Constanza; Riera-Monroig, Josep; Combalia, Andrea; Bosch-Amate, Xavier; Morgado-Carrasco, Daniel; Pigem, Ramon; Toll-Abelló, Agustí; Martí-Martí, Ignasi; Rizo-Potau, Daniel; Serra-García, Laura; Alamon-Reig, Francesc; Iranzo, Pilar; Almuedo-Riera, Alex; Muñoz, Jose; Puig, Susana; Mascaró, José M. title: Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity date: 2020-10-12 journal: J Clin Med DOI: 10.3390/jcm9103261 sha: doc_id: 325307 cord_uid: agaau27o file: cache/cord-325316-uffxyas1.json key: cord-325316-uffxyas1 authors: Gagliano, Annalisa; Villani, Pier Giorgio; Co’, Francesca M; Manelli, Anna; Paglia, Stefano; Bisagni, Pietro A. G.; Perotti, Gabriele M; Storti, Enrico; Lombardo, Massimo title: COVID-19 Epidemic in the Middle Province of Northern Italy: Impact, Logistics, and Strategy in the First Line Hospital date: 2020-03-24 journal: Disaster medicine and public health preparedness DOI: 10.1017/dmp.2020.51 sha: doc_id: 325316 cord_uid: uffxyas1 file: cache/cord-325793-5vrr7msw.json key: cord-325793-5vrr7msw authors: Lahiry, Anup K.; Grover, Chander; Mubashir, Syed; Ashique, Karalikkattil T.; Madura, C; Goyal, Nilesh; Talwar, Ankur; Gupta, Sanjeev; Gulanikar, Anirudh D.; Das, Sidhartha title: Dermatosurgery Practice and Implications of COVID-19 Pandemic: Recommendations by IADVL SIG Dermatosurgery (IADVL Academy) date: 2020-05-10 journal: Indian Dermatol Online J DOI: 10.4103/idoj.idoj_237_20 sha: doc_id: 325793 cord_uid: 5vrr7msw file: cache/cord-325869-3mvjc805.json key: cord-325869-3mvjc805 authors: Silvestris, Nicola; Apolone, Giovanni; Botti, Gerardo; Ciliberto, Gennaro; Costantini, Massimo; De Paoli, Paolo; Franceschi, Silvia; Opocher, Giuseppe; Paradiso, Angelo; Pronzato, Paolo; Sgambato, Alessandro; De Maria, Ruggero title: A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave? date: 2020-06-11 journal: J Exp Clin Cancer Res DOI: 10.1186/s13046-020-01614-x sha: doc_id: 325869 cord_uid: 3mvjc805 file: cache/cord-325421-1ysn0kyr.json key: cord-325421-1ysn0kyr authors: Christensen, Johanna; Kumar, Dhiren; Moinuddin, Irfan; Bryson, Alexandra; Kashi, Zahra; Kimball, Pamela; Levy, Marlon; Kamal, Layla; King, Anne; Gupta, Gaurav title: Covid-19 Viremia, Serologies and Clinical Course in a Case Series of Transplant Recipients date: 2020-09-03 journal: Transplant Proc DOI: 10.1016/j.transproceed.2020.08.042 sha: doc_id: 325421 cord_uid: 1ysn0kyr file: cache/cord-325649-zzhsrytw.json key: cord-325649-zzhsrytw authors: Rispoli, Rossella; Diamond, Mathew E.; Balsano, Massimo; Cappelletto, Barbara title: Spine surgery in Italy in the COVID-19 era: Proposal for assessing and responding to the regional state of emergency date: 2020-08-07 journal: World Neurosurg DOI: 10.1016/j.wneu.2020.08.001 sha: doc_id: 325649 cord_uid: zzhsrytw file: cache/cord-325783-pqonn0as.json key: cord-325783-pqonn0as authors: Nicholls, John M; Poon, Leo LM; Lee, Kam C; Ng, Wai F; Lai, Sik T; Leung, Chung Y; Chu, Chung M; Hui, Pak K; Mak, Kong L; Lim, Wilna; Yan, Kin W; Chan, Kwok H; Tsang, Ngai C; Guan, Yi; Yuen, Kwok Y; Malik Peiris, JS title: Lung pathology of fatal severe acute respiratory syndrome date: 2003-05-24 journal: Lancet DOI: 10.1016/s0140-6736(03)13413-7 sha: doc_id: 325783 cord_uid: pqonn0as file: cache/cord-325766-hbppklm5.json key: cord-325766-hbppklm5 authors: Brienza, Nicola; Puntillo, Filomena; Romagnoli, Stefano; Tritapepe, Luigi title: Acute Kidney Injury in Coronavirus Disease 2019 Infected Patients: A Meta-Analytic Study date: 2020-07-02 journal: Blood Purif DOI: 10.1159/000509274 sha: doc_id: 325766 cord_uid: hbppklm5 file: cache/cord-325970-ivtunxrd.json key: cord-325970-ivtunxrd authors: Yerramilli, Divya; Xu, Amy J.; Gillespie, Erin F.; Shepherd, Annemarie F.; Beal, Kathryn; Gomez, Daniel; Yamada, Josh; Tsai, C. Jillian; Yang, T. Jonathan title: Palliative Radiotherapy for Oncologic Emergencies in the setting of COVID-19: Approaches to Balancing Risks and Benefits date: 2020-04-08 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.04.001 sha: doc_id: 325970 cord_uid: ivtunxrd file: cache/cord-325863-3t73v4ng.json key: cord-325863-3t73v4ng authors: Foss, Francine M.; Rubinowitz, Ami; Landry, Marie L.; Isufi, Iris; Gowda, Lohith; Seropian, Stuart; Perreault, Sarah; Shenoi, Sheela V. title: Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant patient on Ruxolitinib date: 2020-06-25 journal: Clin Lymphoma Myeloma Leuk DOI: 10.1016/j.clml.2020.06.014 sha: doc_id: 325863 cord_uid: 3t73v4ng file: cache/cord-325631-c7jwizpj.json key: cord-325631-c7jwizpj authors: Masetti, Chiara; Generali, Elena; Colapietro, Francesca; Voza, Antonio; Cecconi, Maurizio; Messina, Antonio; Omodei, Paolo; Angelini, Claudio; Ciccarelli, Michele; Badalamenti, Salvatore; Canonica, G. Walter; Lleo, Ana; Aghemo, Alessio title: High mortality in COVID‐19 patients with mild respiratory disease date: 2020-06-29 journal: Eur J Clin Invest DOI: 10.1111/eci.13314 sha: doc_id: 325631 cord_uid: c7jwizpj file: cache/cord-326185-gjte739i.json key: cord-326185-gjte739i authors: Mukherjee, Pratik; Lim, Tze Chwan; Chawla, Ashish; Chou, Hong; Peh, Wilfred C G title: Adaptability and responsiveness: keys to operational measures in a regional hospital radiology department during the current COVID-19 pandemic date: 2020-06-19 journal: BJR Open DOI: 10.1259/bjro.20200017 sha: doc_id: 326185 cord_uid: gjte739i file: cache/cord-325700-f102uk2m.json key: cord-325700-f102uk2m authors: Fraser, Douglas D.; Slessarev, Marat; Martin, Claudio M.; Daley, Mark; Patel, Maitray A.; Miller, Michael R.; Patterson, Eric K.; O’Gorman, David B.; Gill, Sean E.; Wishart, David S.; Mandal, Rupasri; Cepinskas, Gediminas title: Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers date: 2020-10-21 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000272 sha: doc_id: 325700 cord_uid: f102uk2m file: cache/cord-326023-vwukiwe4.json key: cord-326023-vwukiwe4 authors: Leung, Char title: Risk factors for predicting mortality in elderly patients with COVID-19: a review of clinical data in China date: 2020-04-27 journal: Mech Ageing Dev DOI: 10.1016/j.mad.2020.111255 sha: doc_id: 326023 cord_uid: vwukiwe4 file: cache/cord-325933-1qvpofvp.json key: cord-325933-1qvpofvp authors: Samrah, Shaher M; Al-Mistarehi, Abdel-Hameed; Aleshawi, Abdelwahab J; Khasawneh, Aws G; Momany, Suleiman M; Momany, Baker S; Abu Za’nouneh, Faris J; Keelani, Thekra; Alshorman, Abrar; Khassawneh, Basheer Y title: Depression and Coping Among COVID-19-Infected Individuals After 10 Days of Mandatory in-Hospital Quarantine, Irbid, Jordan date: 2020-10-06 journal: Psychol Res Behav Manag DOI: 10.2147/prbm.s267459 sha: doc_id: 325933 cord_uid: 1qvpofvp file: cache/cord-326703-akn92p1r.json key: cord-326703-akn92p1r authors: Bartoletti, Michele; Giannella, Maddalena; Scudeller, Luigia; Tedeschi, Sara; Rinaldi, Matteo; Bussini, Linda; Fornaro, Giacomo; Pascale, Renato; Pancaldi, Livia; Pasquini, Zeno; Trapani, Filippo; Badia, Lorenzo; Campoli, Caterina; Tadolini, Marina; Attard, Luciano; Puoti, Massimo; Merli, Marco; Mussini, Cristina; Menozzi, Marianna; Meschiari, Marianna; Codeluppi, Mauro; Barchiesi, Francesco; Cristini, Francesco; Saracino, Annalisa; Licci, Alberto; Rapuano, Silvia; Tonetti, Tommaso; Gaibani, Paolo; Ranieri, Vito Marco; Viale, Pierluigi title: Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-Cov-2 infection: a multicenter cohort study (PREDI-CO study) date: 2020-08-08 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2020.08.003 sha: doc_id: 326703 cord_uid: akn92p1r file: cache/cord-326272-ya3r0h1t.json key: cord-326272-ya3r0h1t authors: Dobesh, Paul P.; Trujillo, Toby C. title: Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID‐19 date: 2020-10-01 journal: Pharmacotherapy DOI: 10.1002/phar.2465 sha: doc_id: 326272 cord_uid: ya3r0h1t file: cache/cord-325971-volbaipv.json key: cord-325971-volbaipv authors: Neupane, Karun; Ahmed, Zahoor; Pervez, Hira; Ashraf, Rabia; Majeed, Aneela title: Potential Treatment Options for COVID-19: A Comprehensive Review of Global Pharmacological Development Efforts date: 2020-06-26 journal: Cureus DOI: 10.7759/cureus.8845 sha: doc_id: 325971 cord_uid: volbaipv file: cache/cord-326747-zwp13awk.json key: cord-326747-zwp13awk authors: Sever, Mustafa; Mordeniz, Cengiz; Sever, Fidan; Dokur, Mehmet title: Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients date: 2009-12-28 journal: J Clin Med Res DOI: 10.4021/jocmr2009.12.1283 sha: doc_id: 326747 cord_uid: zwp13awk file: cache/cord-325963-d0hvukbu.json key: cord-325963-d0hvukbu authors: Faes, Christel; Abrams, Steven; Van Beckhoven, Dominique; Meyfroidt, Geert; Vlieghe, Erika; Hens, Niel title: Time between Symptom Onset, Hospitalisation and Recovery or Death: Statistical Analysis of Belgian COVID-19 Patients date: 2020-10-17 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17207560 sha: doc_id: 325963 cord_uid: d0hvukbu file: cache/cord-326643-obfvi3ms.json key: cord-326643-obfvi3ms authors: Lo Giudice, Roberto title: The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) in Dentistry. Management of Biological Risk in Dental Practice date: 2020-04-28 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17093067 sha: doc_id: 326643 cord_uid: obfvi3ms file: cache/cord-326017-qw4qynqv.json key: cord-326017-qw4qynqv authors: Laskar, Partha; Yallapu, Murali M.; Chauhan, Subhash C. title: “Tomorrow Never Dies”: Recent Advances in Diagnosis, Treatment, and Prevention Modalities against Coronavirus (COVID-19) amid Controversies date: 2020-08-06 journal: Diseases DOI: 10.3390/diseases8030030 sha: doc_id: 326017 cord_uid: qw4qynqv file: cache/cord-326468-xcy7v1tf.json key: cord-326468-xcy7v1tf authors: Mehta, R. M.; Bansal, S.; Bysani, S.; Kalpakam, H. title: A shorter symptom-onset to remdesivir treatment (SORT) interval is associated with a lower mortality in moderate-to-severe COVID-19: A real-world analysis date: 2020-11-10 journal: nan DOI: 10.1101/2020.11.05.20226373 sha: doc_id: 326468 cord_uid: xcy7v1tf file: cache/cord-326752-45ckkv01.json key: cord-326752-45ckkv01 authors: Barnett, Brian; Esper, Frank; Foster, Charles B. title: Keeping the wolf at bay: Infection prevention and control measures for inpatient psychiatric facilities in the time of COVID-19 date: 2020-07-12 journal: Gen Hosp Psychiatry DOI: 10.1016/j.genhosppsych.2020.07.004 sha: doc_id: 326752 cord_uid: 45ckkv01 file: cache/cord-326851-0jxdnm1l.json key: cord-326851-0jxdnm1l authors: Lee, Sang M.; Lee, DonHee title: Lessons Learned from Battling COVID-19: The Korean Experience date: 2020-10-16 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17207548 sha: doc_id: 326851 cord_uid: 0jxdnm1l file: cache/cord-326354-fhafg41x.json key: cord-326354-fhafg41x authors: Pesavento, Raffaele; Ceccato, Davide; Pasquetto, Giampaolo; Monticelli, Jacopo; Leone, Lucia; Frigo, Annachiara; Gorgi, Davide; Postal, Anna; Marchese, Giuseppe Maria; Cipriani, Alberto; Saller, Alois; Sarais, Cristiano; Criveller, Pietro; Gemelli, Marco; Capone, Federico; Fioretto, Paola; Pagano, Claudio; Rossato, Marco; Avogaro, Angelo; Simioni, Paolo; Prandoni, Paolo; Vettor, Roberto title: The hazard of (sub)therapeutic doses of anticoagulants in non‐critically ill patients with Covid‐19: the Padua province experience date: 2020-07-21 journal: J Thromb Haemost DOI: 10.1111/jth.15022 sha: doc_id: 326354 cord_uid: fhafg41x file: cache/cord-326751-fn43p19j.json key: cord-326751-fn43p19j authors: Herold, Christian J.; Sailer, Johannes G. title: Community-acquired and nosocomial pneumonia date: 2004-01-29 journal: European radiology DOI: 10.1007/s00330-003-2162-7 sha: doc_id: 326751 cord_uid: fn43p19j file: cache/cord-326984-o27rp468.json key: cord-326984-o27rp468 authors: CHIEN, Jung‐Yien; HSUEH, Po‐Ren; CHENG, Wern‐Cherng; YU, Chong‐Jen; YANG, Pan‐Chyr title: Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome date: 2006-10-16 journal: Respirology DOI: 10.1111/j.1440-1843.2006.00942.x sha: doc_id: 326984 cord_uid: o27rp468 file: cache/cord-326807-dii4u9gj.json key: cord-326807-dii4u9gj authors: Kow, Chia Siang; Hasan, Syed Shahzad title: Use of low-molecular-weight heparin in COVID-19 patients date: 2020-06-17 journal: J Vasc Surg Venous Lymphat Disord DOI: 10.1016/j.jvsv.2020.06.006 sha: doc_id: 326807 cord_uid: dii4u9gj file: cache/cord-326834-eeldyj2u.json key: cord-326834-eeldyj2u authors: Graziani, Desirée; Soriano, Joan B; Del Rio-Bermudez, Carlos; Morena, Diego; Díaz, Teresa; Castillo, María; Alonso, Miguel; Ancochea, Julio; Lumbreras, Sara; Izquierdo, José Luis title: Characteristics and Prognosis of COVID-19 in Patients with COPD date: 2020-10-12 journal: J Clin Med DOI: 10.3390/jcm9103259 sha: doc_id: 326834 cord_uid: eeldyj2u file: cache/cord-327017-b2refzfw.json key: cord-327017-b2refzfw authors: Elbeddini, Ali; Yeats, Aniko title: Pharmacist intervention amid the coronavirus disease 2019 (COVID-19) pandemic: from direct patient care to telemedicine date: 2020-05-27 journal: J Pharm Policy Pract DOI: 10.1186/s40545-020-00229-z sha: doc_id: 327017 cord_uid: b2refzfw file: cache/cord-326883-j7pbe50g.json key: cord-326883-j7pbe50g authors: Stöbe, Stephan; Richter, Sarah; Seige, Markus; Stehr, Sebastian; Laufs, Ulrich; Hagendorff, Andreas title: Echocardiographic characteristics of patients with SARS-CoV-2 infection date: 2020-08-14 journal: Clin Res Cardiol DOI: 10.1007/s00392-020-01727-5 sha: doc_id: 326883 cord_uid: j7pbe50g file: cache/cord-327165-vlyfbiem.json key: cord-327165-vlyfbiem authors: Montorfano, Lisandro; Miret, Rafael; Rahman, Asad Ur; Alonso, Mileydis; Maron, David J.; Roy, Mayank; Ferri, Francisco; Bejarano, Pablo; Wexner, Steven D. title: Colorectal surgery obesity-related morbidity during COVID-19 date: 2020-07-09 journal: Surg Obes Relat Dis DOI: 10.1016/j.soard.2020.06.011 sha: doc_id: 327165 cord_uid: vlyfbiem file: cache/cord-326991-m0lfk0a9.json key: cord-326991-m0lfk0a9 authors: Nuñez, Jorge H.; Porcel, Juan Antonio; Pijoan, Joan; Batalla, Lledó; Teixidor, Jordi; Guerra-Farfan, Ernesto; Minguell, Joan title: Rethinking Trauma Hospital Services in one of Spain's Largest University Hospitals during the COVID-19 pandemic. How can we organize and help? Our experience. date: 2020-09-25 journal: Injury DOI: 10.1016/j.injury.2020.09.055 sha: doc_id: 326991 cord_uid: m0lfk0a9 file: cache/cord-327148-dzozl70h.json key: cord-327148-dzozl70h authors: Tahmassebi, Ramon; Bates, Peter; Trompeter, Alex; Bhattacharya, Rajarshi; El-Daly, Ibraheim; Jeyaseelan, Lucky; Pearse, Michael title: Reflections from London’s Level-1 Major Trauma Centres during the COVID crisis date: 2020-06-26 journal: Eur J Orthop Surg Traumatol DOI: 10.1007/s00590-020-02724-0 sha: doc_id: 327148 cord_uid: dzozl70h file: cache/cord-327370-zo0n8wf6.json key: cord-327370-zo0n8wf6 authors: Vadukul, Prakash; Sharma, Deepak S; Vincent, Paul title: Massive pulmonary embolism following recovery from COVID-19 infection: inflammation, thrombosis and the role of extended thromboprophylaxis date: 2020-09-13 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-238168 sha: doc_id: 327370 cord_uid: zo0n8wf6 file: cache/cord-326785-le2t1l8g.json key: cord-326785-le2t1l8g authors: nan title: Pathological Society of Great Britain and Ireland. 163rd meeting, 3–5 July 1991 date: 2005-06-15 journal: J Pathol DOI: 10.1002/path.1711640412 sha: doc_id: 326785 cord_uid: le2t1l8g file: cache/cord-326994-y8p724s4.json key: cord-326994-y8p724s4 authors: Mohamad, Osama; Roach, Mack title: Delaying Dilemmas: Coronavirus Complications Impacting the Management of Prostate Cancer date: 2020-10-01 journal: Int J Radiat Oncol Biol Phys DOI: 10.1016/j.ijrobp.2020.07.009 sha: doc_id: 326994 cord_uid: y8p724s4 file: cache/cord-327125-86ocr70d.json key: cord-327125-86ocr70d authors: Iehara, Tomoko; Manabe, Atsushi; Hosoi, Hajime title: Statement on the prevention and treatment of COVID‐19 in patients with pediatric cancer in Japan date: 2020-06-22 journal: Pediatr Blood Cancer DOI: 10.1002/pbc.28440 sha: doc_id: 327125 cord_uid: 86ocr70d file: cache/cord-327413-zdbnoy1q.json key: cord-327413-zdbnoy1q authors: Bendjelid, Karim; Muller, Laurent title: Hemodynamic monitoring of Covid-19 patients. Classical methods and new paradigms date: 2020-09-04 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.09.001 sha: doc_id: 327413 cord_uid: zdbnoy1q file: cache/cord-327397-8rxjju0t.json key: cord-327397-8rxjju0t authors: Zhang, H.-Y.; Wang, L.-W.; Chen, Y.-Y.; Shen, X.-K.; Wang, Q.; Yan, Y.-Q.; Yu, Y.; Wu, Q.; Wang, X.; Zhong, Y.-H.; Chua Lee Kiang, M.; Xie, C.-H. title: A Multicentre Study of 2019 Novel Coronavirus Disease Outcomes of Cancer Patients in Wuhan, China date: 2020-03-26 journal: nan DOI: 10.1101/2020.03.21.20037127 sha: doc_id: 327397 cord_uid: 8rxjju0t file: cache/cord-327214-kcbxyhhh.json key: cord-327214-kcbxyhhh authors: Eketunde, Adenike O; Mellacheruvu, Sai Priyanka; Oreoluwa, Philip title: A Review of Postmortem Findings in Patients With COVID-19 date: 2020-07-28 journal: Cureus DOI: 10.7759/cureus.9438 sha: doc_id: 327214 cord_uid: kcbxyhhh file: cache/cord-327432-ogw27tob.json key: cord-327432-ogw27tob authors: Zhang, Feng-jian; Hu, De-ying; Liu, Yi-lan; Li, Hong; Zhu, Xiao-ping; Pan, Shao-shan title: Expert Consensus on Nurses’ Human Caring for COVID-19 Patients in Different Sites date: 2020-08-07 journal: Curr Med Sci DOI: 10.1007/s11596-020-2222-0 sha: doc_id: 327432 cord_uid: ogw27tob file: cache/cord-327349-rxb6zfoc.json key: cord-327349-rxb6zfoc authors: Au, Lewis; Boos, Laura Amanda; Swerdlow, Anthony; Byrne, Fiona; Shepherd, Scott T.C.; Fendler, Annika; Turajlic, Samra title: Cancer, COVID-19, and antiviral immunity: the CAPTURE study date: 2020-09-03 journal: Cell DOI: 10.1016/j.cell.2020.09.005 sha: doc_id: 327349 cord_uid: rxb6zfoc file: cache/cord-327442-e02y93f6.json key: cord-327442-e02y93f6 authors: Kastritis, Efstathios; Kitas, George D.; Vassilopoulos, Dimitrios; Giannopoulos, Georgios; Dimopoulos, Meletios A.; Sfikakis, Petros P. title: Systemic autoimmune diseases, anti-rheumatic therapies, COVID-19 infection risk and patient outcomes date: 2020-07-11 journal: Rheumatol Int DOI: 10.1007/s00296-020-04629-x sha: doc_id: 327442 cord_uid: e02y93f6 file: cache/cord-327545-y3vejwtr.json key: cord-327545-y3vejwtr authors: Shannon, Vickie R.; Anderson, Ronald; Blidner, Ada; Choi, Jennifer; Cooksley, Tim; Dougan, Michael; Glezerman, Ilya; Ginex, Pamela; Girotra, Monica; Gupta, Dipti; Johnson, Douglas B.; Suarez-Almazor, Maria E.; Rapoport, Bernardo L. title: Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity date: 2020-09-03 journal: Support Care Cancer DOI: 10.1007/s00520-020-05708-2 sha: doc_id: 327545 cord_uid: y3vejwtr file: cache/cord-327611-g2ssh0fk.json key: cord-327611-g2ssh0fk authors: Ishkanian, Amy; Mehl, Alla title: Clinical Conundrum: Dysphagia in a Patient with COVID-19 and Progressive Muscle Weakness date: 2020-10-31 journal: Dysphagia DOI: 10.1007/s00455-020-10205-z sha: doc_id: 327611 cord_uid: g2ssh0fk file: cache/cord-327577-c0d09cyk.json key: cord-327577-c0d09cyk authors: Zamora, Alberto; Rivera, Agnés title: Heart failure, zip code, and telemetry: a trinomial in need of understanding date: 2020-08-31 journal: Clínica e Investigación en Arteriosclerosis (English Edition) DOI: 10.1016/j.artere.2020.07.005 sha: doc_id: 327577 cord_uid: c0d09cyk file: cache/cord-327415-nu1msnui.json key: cord-327415-nu1msnui authors: Kadiane-Oussou, N’dri Juliette; Klopfenstein, Timothee; Royer, Pierre-Yves; Toko, Lynda; Gendrin, Vincent; Zayet, Souheil title: COVID-19: comparative clinical features and outcome in 114 patients with or without pneumonia (Nord Franche-Comte Hospital, France) date: 2020-10-10 journal: Microbes Infect DOI: 10.1016/j.micinf.2020.10.002 sha: doc_id: 327415 cord_uid: nu1msnui file: cache/cord-327632-2hz94uuw.json key: cord-327632-2hz94uuw authors: Lv, Na; Sun, Ming; Polonowita, Ajith; Mei, Li; Guan, Guangzhao title: Management of oral medicine emergencies during COVID-19: A study to develop practice guidelines date: 2020-08-07 journal: J Dent Sci DOI: 10.1016/j.jds.2020.07.016 sha: doc_id: 327632 cord_uid: 2hz94uuw file: cache/cord-327481-m9r0p84v.json key: cord-327481-m9r0p84v authors: Duployez, Nicolas; Demonchy, Jordane; Berthon, Céline; Goutay, Julien; Caplan, Morgan; Moreau, Anne-Sophie; Bignon, Anne; Marceau-Renaut, Alice; Garrigue, Delphine; Raczkiewicz, Imelda; Geffroy, Sandrine; Bucci, Maxime; Alidjinou, Kazali; Demaret, Julie; Labalette, Myriam; Brousseau, Thierry; Dupont, Annabelle; Rauch, Antoine; Poissy, Julien; Susen, Sophie; Preudhomme, Claude; Quesnel, Bruno title: Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19 date: 2020-07-21 journal: Cancers (Basel) DOI: 10.3390/cancers12071992 sha: doc_id: 327481 cord_uid: m9r0p84v file: cache/cord-327597-fgnrujsf.json key: cord-327597-fgnrujsf authors: Han, Susie A.; Koch, Valerie Gutmann title: Clinical and Ethical Considerations in Allocation of Ventilators in an Influenza Pandemic or Other Public Health Disaster: A Comparison of the 2007 and 2015 New York State Ventilator Allocation Guidelines date: 2020-07-14 journal: Disaster medicine and public health preparedness DOI: 10.1017/dmp.2020.232 sha: doc_id: 327597 cord_uid: fgnrujsf file: cache/cord-327609-no58ucyq.json key: cord-327609-no58ucyq authors: Murkey, Jamie A.; Chew, Kara W.; Carlson, Margrit; Shannon, Chelsea L.; Sirohi, Deepika; Sample, Hannah A.; Wilson, Michael R.; Vespa, Paul; Humphries, Romney M.; Miller, Steve; Klausner, Jeffrey D.; Chiu, Charles Y. title: Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing date: 2017-06-13 journal: Open Forum Infect Dis DOI: 10.1093/ofid/ofx121 sha: doc_id: 327609 cord_uid: no58ucyq file: cache/cord-327622-ezgufe24.json key: cord-327622-ezgufe24 authors: Kaur, Ramandeep; Weiss, Tyler T.; Perez, Andrew; Fink, James B.; Chen, Rongchang; Luo, Fengming; Liang, Zongan; Mirza, Sara; Li, Jie title: Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date: 2020-09-23 journal: Crit Care DOI: 10.1186/s13054-020-03231-8 sha: doc_id: 327622 cord_uid: ezgufe24 file: cache/cord-327641-hqnem2zs.json key: cord-327641-hqnem2zs authors: Ji, Ying-Jie; Duan, Xue-Zhang; Gao, Xu-Dong; Li, Lei; Li, Chen; Ji, Dong; Li, Wen-Gang; Wang, Li-Fu; Meng, Yu-Hua; Yang, Xiao; Ling, Bin-Fang; Song, Xue-Ai; Gu, Mei-Lei; Jiang, Tao; Koroma, She-Ku M.; Bangalie, James; Duan, Hui-Juan title: Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone date: 2016-11-03 journal: Infect Dis Poverty DOI: 10.1186/s40249-016-0195-9 sha: doc_id: 327641 cord_uid: hqnem2zs file: cache/cord-327690-di7hfghi.json key: cord-327690-di7hfghi authors: Yang, Xiaobo; Yu, Yuan; Xu, Jiqian; Shu, Huaqing; Xia, Jia'an; Liu, Hong; Wu, Yongran; Zhang, Lu; Yu, Zhui; Fang, Minghao; Yu, Ting; Wang, Yaxin; Pan, Shangwen; Zou, Xiaojing; Yuan, Shiying; Shang, You title: Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study date: 2020-02-24 journal: Lancet Respir Med DOI: 10.1016/s2213-2600(20)30079-5 sha: doc_id: 327690 cord_uid: di7hfghi file: cache/cord-327720-m6cofbj6.json key: cord-327720-m6cofbj6 authors: Chakrabarti, Amitabha; Bandyopadhyay, Manujesh title: Understanding the practice of thoracic surgery during the COVID-19 pandemic date: 2020-08-11 journal: Indian J Thorac Cardiovasc Surg DOI: 10.1007/s12055-020-01025-9 sha: doc_id: 327720 cord_uid: m6cofbj6 file: cache/cord-327764-4nlg26p5.json key: cord-327764-4nlg26p5 authors: Sun, Da-wei; Zhang, Dong; Tian, Run-hui; Li, Yang; Wang, Yu-shi; Cao, Jie; Tang, Ying; Zhang, Nan; Zan, Tao; Gao, Lan; Huang, Yan-zhu; Cui, Chang-lei; Wang, Dong-xuan; Zheng, Yang; Lv, Guo-yue title: The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: a sentinel? date: 2020-05-14 journal: Clin Chim Acta DOI: 10.1016/j.cca.2020.05.027 sha: doc_id: 327764 cord_uid: 4nlg26p5 file: cache/cord-327818-1abweqko.json key: cord-327818-1abweqko authors: Kersebaum, Dilara; Fabig, Sophie-Charlotte; Sendel, Manon; Sachau, Juliane; Lassen, Josephine; Rehm, Stefanie; Hüllemann, Philipp; Baron, Ralf; Gierthmühlen, Janne title: The early influence of COVID-19 pandemic-associated restrictions on pain, mood, and everyday life of patients with painful polyneuropathy date: 2020-10-14 journal: Pain Rep DOI: 10.1097/pr9.0000000000000858 sha: doc_id: 327818 cord_uid: 1abweqko file: cache/cord-327820-4bm7b934.json key: cord-327820-4bm7b934 authors: Li, Ning; Liu, Tingmin; Chen, Hualing; Liao, Jianmei; Li, Haisheng; Luo, Qizhi; Song, Huapei; Xiang, Fei; Tan, Jianglin; Zhou, Junyi; Hu, Gaozhong; Yuan, Zhiqiang; Peng, Yizhi; Luo, Gaoxing title: Management strategies for the burn ward during COVID-19 pandemic date: 2020-04-02 journal: Burns DOI: 10.1016/j.burns.2020.03.013 sha: doc_id: 327820 cord_uid: 4bm7b934 file: cache/cord-327827-oliw4ee5.json key: cord-327827-oliw4ee5 authors: Sweid, Ahmad; Hammoud, Batoul; Weinberg, Joshua H; Oneissi, Mazen; Raz, Eytan; Shapiro, Maksim; DePrince, Maureen; Tjoumakaris, Stavropoula; Gooch, Michael R; Herial, Nabeel A; Zarzour, Hekmat; Romo, Victor; Rosenwasser, Robert H; Jabbour, Pascal title: Letter: Thrombotic Neurovascular Disease in COVID-19 Patients date: 2020-06-04 journal: Neurosurgery DOI: 10.1093/neuros/nyaa254 sha: doc_id: 327827 cord_uid: oliw4ee5 file: cache/cord-327836-6o66a4i5.json key: cord-327836-6o66a4i5 authors: Zuily, S; Dufrost, V; Wahl, D title: Thrombose artérielle et veineuse au cours du COVID-19 date: 2020-08-07 journal: Arch Mal Coeur Vaiss Pratique DOI: 10.1016/j.amcp.2020.08.003 sha: doc_id: 327836 cord_uid: 6o66a4i5 file: cache/cord-327961-ysatxwph.json key: cord-327961-ysatxwph authors: Wang, Le; Feng, Zhishan; Shuai, Jinfeng; Liu, Jianhua; Li, Guixia title: Risk factors of 90-day rehospitalization following discharge of pediatric patients hospitalized with mycoplasma Pneumoniae pneumonia date: 2019-11-12 journal: BMC Infect Dis DOI: 10.1186/s12879-019-4616-9 sha: doc_id: 327961 cord_uid: ysatxwph file: cache/cord-327989-6p39cx2e.json key: cord-327989-6p39cx2e authors: Everaert, Bert; Muylle, Jan; Twicker, Theodorus Bartholomeus title: Emerging cardiological issues during the COVID‐19 pandemic date: 2020-05-16 journal: Eur J Clin Invest DOI: 10.1111/eci.13270 sha: doc_id: 327989 cord_uid: 6p39cx2e file: cache/cord-328039-xt17gvcp.json key: cord-328039-xt17gvcp authors: Olson, Michael C.; Lubner, Meghan G.; Menias, Christine O.; Mellnick, Vincent M.; Gettle, Lori Mankowski; Kim, David H.; Elsayes, Khaled M.; Pickhardt, Perry J. title: RadioGraphics Update: Venous Thrombosis and Hypercoagulability in the Abdomen and Pelvis—Findings in COVID-19 date: 2020-07-10 journal: Radiographics DOI: 10.1148/rg.2020200119 sha: doc_id: 328039 cord_uid: xt17gvcp file: cache/cord-328040-5qd05e4r.json key: cord-328040-5qd05e4r authors: Zhao, Xin-Ying; Xu, Xuan-Xuan; Yin, Hai-Sen; Hu, Qin-Ming; Xiong, Tao; Tang, Yuan-Yan; Yang, Ai-Ying; Yu, Bao-Ping; Huang, Zhi-Ping title: Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study date: 2020-04-29 journal: BMC Infect Dis DOI: 10.1186/s12879-020-05010-w sha: doc_id: 328040 cord_uid: 5qd05e4r file: cache/cord-328068-qoz85x3r.json key: cord-328068-qoz85x3r authors: Alanio, Alexandre title: The presence of Pneumocystis jirovecii in critically ill patients with COVID-19 date: 2020-11-04 journal: J Infect DOI: 10.1016/j.jinf.2020.10.034 sha: doc_id: 328068 cord_uid: qoz85x3r file: cache/cord-328113-eczjjc2v.json key: cord-328113-eczjjc2v authors: D’Alessandro, Angelo; Thomas, Tiffany; Dzieciatkowska, Monika; Hill, Ryan C.; Francis, Richard O.; Hudson, Krystalyn E.; Zimring, James C.; Hod, Eldad A.; Spitalnik, Steven L.; Hansen, Kirk C. title: Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level date: 2020-07-30 journal: J Proteome Res DOI: 10.1021/acs.jproteome.0c00365 sha: doc_id: 328113 cord_uid: eczjjc2v file: cache/cord-328147-61gtx2h2.json key: cord-328147-61gtx2h2 authors: Lopez-Mendez, Ivan; Aquino-Matus, Jorge; Gall, Sofia Murua-Beltrán; Prieto-Nava, Jose D.; Juarez-Hernandez, Eva; Uribe, Misael; Castro-Narro, Graciela title: Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19) date: 2020-10-21 journal: Ann Hepatol DOI: 10.1016/j.aohep.2020.09.015 sha: doc_id: 328147 cord_uid: 61gtx2h2 file: cache/cord-328214-2azb8789.json key: cord-328214-2azb8789 authors: Piper-Vallillo, Andrew J.; Mooradian, Meghan J.; Meador, Catherine B.; Yeap, Beow Y.; Peterson, Jennifer; Sakhi, Mustafa; Do, Andrew; Zubiri, Leyre; Stevens, Sara; Vaughn, Jeanne; Goodwin, Kelly; Gavralidis, Alexander; Willers, Henning; Miller, Adam; Farago, Anna; Piotrowska, Zofia; Lin, Jessica J.; Dagogo-Jack, Ibiayi; Lennes, Inga T.; Sequist, Lecia V.; Temel, Jennifer S.; Heist, Rebecca S.; Digumarthy, Subba; Reynolds, Kerry L.; Gainor, Justin F. title: COVID-19 Infection in a Lung Cancer Patient Population: Incidence, Presentation and Alternative Diagnostic Considerations date: 2020-11-12 journal: JTO Clin Res Rep DOI: 10.1016/j.jtocrr.2020.100124 sha: doc_id: 328214 cord_uid: 2azb8789 file: cache/cord-328220-toeq4xq0.json key: cord-328220-toeq4xq0 authors: Smith, Kelly; Krajewski, Kristin C; Krajewski, Michael P title: Practical Considerations in Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID-19 date: 2020-07-06 journal: Am J Health Syst Pharm DOI: 10.1093/ajhp/zxaa245 sha: doc_id: 328220 cord_uid: toeq4xq0 file: cache/cord-328289-3h3kmjlz.json key: cord-328289-3h3kmjlz authors: Iadecola, Costantino; Anrather, Josef; Kamel, Hooman title: Effects of COVID-19 on the nervous system date: 2020-08-19 journal: Cell DOI: 10.1016/j.cell.2020.08.028 sha: doc_id: 328289 cord_uid: 3h3kmjlz file: cache/cord-328294-gii1b7s7.json key: cord-328294-gii1b7s7 authors: Doty, Richard L.; Mishra, Anupam title: Olfaction and Its Alteration by Nasal Obstruction, Rhinitis, and Rhinosinusitis date: 2009-01-02 journal: Laryngoscope DOI: 10.1097/00005537-200103000-00008 sha: doc_id: 328294 cord_uid: gii1b7s7 file: cache/cord-328307-378cfb23.json key: cord-328307-378cfb23 authors: Shirazi, Samira; Mami, Sanaz; Mohtadi, Negar; Ghaysouri, Abas; Tavan, Hamed; Nazari, Ali; Kokhazadeh, Taleb; Mollazadeh, Reza title: Sudden cardiac death in COVID-19 patients, a report of three cases date: 2020-07-03 journal: Future cardiology DOI: 10.2217/fca-2020-0082 sha: doc_id: 328307 cord_uid: 378cfb23 file: cache/cord-328384-jzfr2t3p.json key: cord-328384-jzfr2t3p authors: Mudatsir, Mudatsir; Fajar, Jonny Karunia; Wulandari, Laksmi; Soegiarto, Gatot; Ilmawan, Muhammad; Purnamasari, Yeni; Mahdi, Bagus Aulia; Jayanto, Galih Dwi; Suhendra, Suhendra; Setianingsih, Yennie Ayu; Hamdani, Romi; Suseno, Daniel Alexander; Agustina, Kartika; Naim, Hamdan Yuwafi; Muchlas, Muchamad; Alluza, Hamid Hunaif Dhofi; Rosida, Nikma Alfi; Mayasari, Mayasari; Mustofa, Mustofa; Hartono, Adam; Aditya, Richi; Prastiwi, Firman; Meku, Fransiskus Xaverius; Sitio, Monika; Azmy, Abdullah; Santoso, Anita Surya; Nugroho, Radhitio Adi; Gersom, Camoya; Rabaan, Ali A.; Masyeni, Sri; Nainu, Firzan; Wagner, Abram L.; Dhama, Kuldeep; Harapan, Harapan title: Predictors of COVID-19 severity: a systematic review and meta-analysis date: 2020-09-09 journal: F1000Res DOI: 10.12688/f1000research.26186.1 sha: doc_id: 328384 cord_uid: jzfr2t3p file: cache/cord-328438-irjo0l4s.json key: cord-328438-irjo0l4s authors: Krittanawong, Chayakrit; Rogers, Albert J.; Johnson, Kipp W.; Wang, Zhen; Turakhia, Mintu P.; Halperin, Jonathan L.; Narayan, Sanjiv M. title: Integration of novel monitoring devices with machine learning technology for scalable cardiovascular management date: 2020-10-09 journal: Nat Rev Cardiol DOI: 10.1038/s41569-020-00445-9 sha: doc_id: 328438 cord_uid: irjo0l4s file: cache/cord-328484-4iptwc3n.json key: cord-328484-4iptwc3n authors: Li, Tao; Lu, Lei; Zhang, Weishuo; Tao, Yu; Wang, Liuming; Bao, Jing; Liu, Bao; Duan, Jun title: Clinical Characteristics of 312 Hospitalized Older Patients with COVID-19 in Wuhan, China date: 2020-07-15 journal: Arch Gerontol Geriatr DOI: 10.1016/j.archger.2020.104185 sha: doc_id: 328484 cord_uid: 4iptwc3n file: cache/cord-328487-glwslgjy.json key: cord-328487-glwslgjy authors: Iannaccone, Sandro; Castellazzi, Paola; Tettamanti, Andrea; Houdayer, Elise; Brugliera, Luigia; de Blasio, Francesco; Cimino, Paolo; Ripa, Marco; Meloni, Carlo; Alemanno, Federica; Scarpellini, Paolo title: ROLE OF REHABILITATION DEPARTMENT FOR ADULT COVID-19 PATIENTS: THE EXPERIENCE OF THE SAN RAFFAELE HOSPITAL OF MILAN date: 2020-06-04 journal: Arch Phys Med Rehabil DOI: 10.1016/j.apmr.2020.05.015 sha: doc_id: 328487 cord_uid: glwslgjy file: cache/cord-328513-81yvcgul.json key: cord-328513-81yvcgul authors: Bellastella, Giuseppe; Maiorino, Maria Ida; Bizzarro, Antonio; Giugliano, Dario; Esposito, Katherine; Bellastella, Antonio; De Bellis, Annamaria title: Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects date: 2016-08-08 journal: Pituitary DOI: 10.1007/s11102-016-0736-z sha: doc_id: 328513 cord_uid: 81yvcgul file: cache/cord-328525-80xk3gln.json key: cord-328525-80xk3gln authors: Baier, Claas; Linderkamp, Christin; Beilken, Andreas; Thol, Felicitas; Heuser, Michael; Ebadi, Ella; Ganzenmueller, Tina; Heim, Albert; Bange, Franz-Christoph title: Influenza and respiratory syncytial virus screening for the detection of asymptomatically infected patients in hematology and oncology date: 2018-09-24 journal: GMS Hyg Infect Control DOI: 10.3205/dgkh000314 sha: doc_id: 328525 cord_uid: 80xk3gln file: cache/cord-328569-1lx3fkv3.json key: cord-328569-1lx3fkv3 authors: Bagate, François; Tuffet, Samuel; Masi, Paul; Perier, François; Razazi, Keyvan; de Prost, Nicolas; Carteaux, Guillaume; Payen, Didier; Mekontso Dessap, Armand title: Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome date: 2020-11-04 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00769-2 sha: doc_id: 328569 cord_uid: 1lx3fkv3 file: cache/cord-328607-lzai90zq.json key: cord-328607-lzai90zq authors: Augoustides, John G. title: Cardiovascular Consequences and Considerations of Coronavirus Infection – Perspectives for the Cardiothoracic Anesthesiologist and Intensivist During the Coronavirus Crisis date: 2020-04-09 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.04.001 sha: doc_id: 328607 cord_uid: lzai90zq file: cache/cord-328640-4g7revha.json key: cord-328640-4g7revha authors: Douedi, Steven; Miskoff, Jeffrey title: Novel coronavirus 2019 (COVID-19): A case report and review of treatments date: 2020-05-08 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000020207 sha: doc_id: 328640 cord_uid: 4g7revha file: cache/cord-328786-gkd9xcxa.json key: cord-328786-gkd9xcxa authors: Mohammad, Laila Malani; Botros, James A.; Chohan, Muhammad Omar title: Necessity of brain imaging in COVID-19 infected patients presenting with acute neurological deficits date: 2020-08-13 journal: Interdiscip Neurosurg DOI: 10.1016/j.inat.2020.100883 sha: doc_id: 328786 cord_uid: gkd9xcxa file: cache/cord-328814-s3963anw.json key: cord-328814-s3963anw authors: XU, Jing; PAN, Li-jia; JIA, Chun-sheng title: Exploration on the feasibility of moxibustion in prevention and treatment of COVID-19 from the perspective of modern medical mechanism date: 2020-06-11 journal: World J Acupunct Moxibustion DOI: 10.1016/j.wjam.2020.06.001 sha: doc_id: 328814 cord_uid: s3963anw file: cache/cord-328829-yywxmioq.json key: cord-328829-yywxmioq authors: Boixeda, Ramon; Rabella, Nuria; Sauca, Goretti; Delgado, Maria; Martínez-Costa, Xavier; Mauri, Montserrat; Vicente, Vanessa; Palomera, Elisabet; Serra-Prat, Mateu; Capdevila, Josep Antón title: Microbiological study of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the usefulness of analytical and clinical parameters in its identification (VIRAE study) date: 2012-05-25 journal: Int J Chron Obstruct Pulmon Dis DOI: 10.2147/copd.s30568 sha: doc_id: 328829 cord_uid: yywxmioq file: cache/cord-328895-p75b7jii.json key: cord-328895-p75b7jii authors: Kim, Yeon-Yong; Bae, Jaekyoung; Lee, Jin-Seok title: Effects of patients’ motives in choosing a provider on determining the type of medical institution date: 2017-11-22 journal: Patient Prefer Adherence DOI: 10.2147/ppa.s148530 sha: doc_id: 328895 cord_uid: p75b7jii file: cache/cord-329152-1ixylnny.json key: cord-329152-1ixylnny authors: Gupta, Shaili; Federman, Daniel G. title: Hospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System date: 2020-04-24 journal: Postgrad Med DOI: 10.1080/00325481.2020.1761668 sha: doc_id: 329152 cord_uid: 1ixylnny file: cache/cord-329215-awxfetdj.json key: cord-329215-awxfetdj authors: Carter, Chris; Osbourne, Michelle; Agagah, Gifty; Aedy, Helen; Notter, Joy title: COVID-19 Disease: invasive ventilation date: 2020-06-01 journal: nan DOI: 10.1016/j.intcar.2020.100004 sha: doc_id: 329215 cord_uid: awxfetdj file: cache/cord-329344-06uk5sjp.json key: cord-329344-06uk5sjp authors: Neumann-Podczaska, Agnieszka; Al-Saad, Salwan R; Karbowski, Lukasz M; Chojnicki, Michal; Tobis, Slawomir; Wieczorowska-Tobis, Katarzyna title: COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review date: 2020-07-23 journal: Aging Dis DOI: 10.14336/ad.2020.0620 sha: doc_id: 329344 cord_uid: 06uk5sjp file: cache/cord-329351-g9qlo3xh.json key: cord-329351-g9qlo3xh authors: Toraih, Eman A.; Elshazli, Rami M.; Hussein, Mohammad H.; Elgaml, Abdelaziz; Amin, Mohamed Nasreldien; El‐Mowafy, Mohammed; El‐Mesery, Mohamed; Ellythy, Assem; Duchesne, Juan; Killackey, Mary T.; Ferdinand, Keith C.; Kandil, Emad; Fawzy, Manal S. title: Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID‐19 patients: A meta‐regression and Decision tree analysis date: 2020-06-12 journal: J Med Virol DOI: 10.1002/jmv.26166 sha: doc_id: 329351 cord_uid: g9qlo3xh file: cache/cord-329444-t8ixrdpq.json key: cord-329444-t8ixrdpq authors: Persaud., Yudy K.; Portnoy, Jay title: Ten Rules for Implementation of a Telemedicine Program to Care for Patients with Asthma date: 2020-10-08 journal: J Allergy Clin Immunol Pract DOI: 10.1016/j.jaip.2020.10.005 sha: doc_id: 329444 cord_uid: t8ixrdpq file: cache/cord-329453-ry1diso2.json key: cord-329453-ry1diso2 authors: Hammer, Mark M.; Zhao, Anna H.; Hunsaker, Andetta R.; Mendicuti, Alejandra Duran; Sodickson, Aaron D.; Boland, Giles W.; Khorasani, Ramin title: Radiologist Reporting and Operational Management for Patients with Suspected COVID-19 date: 2020-06-11 journal: J Am Coll Radiol DOI: 10.1016/j.jacr.2020.06.006 sha: doc_id: 329453 cord_uid: ry1diso2 file: cache/cord-329564-tmi1u224.json key: cord-329564-tmi1u224 authors: Arashiro, Takeshi; Furukawa, Keiichi; Nakamura, Akira title: COVID-19 in 2 Persons with Mild Upper Respiratory Tract Symptoms on a Cruise Ship, Japan date: 2020-06-17 journal: Emerg Infect Dis DOI: 10.3201/eid2606.200452 sha: doc_id: 329564 cord_uid: tmi1u224 file: cache/cord-329582-y4gyw8vz.json key: cord-329582-y4gyw8vz authors: Tham, Hui-Yu; Lau, Jerrald; Lee, Sean Kien-Fatt; Hwang, Stephen; Chan, Dedrick Kok-Hong; Tan, Ker-Kan title: Is There Still a Role for Physical Consultation in Colorectal Cancer Surveillance? date: 2020-08-31 journal: J Gastrointest Surg DOI: 10.1007/s11605-020-04774-5 sha: doc_id: 329582 cord_uid: y4gyw8vz file: cache/cord-329727-h47q76y8.json key: cord-329727-h47q76y8 authors: Sisó-Almirall, Antoni; Kostov, Belchin; Mas-Heredia, Minerva; Vilanova-Rotllan, Sergi; Sequeira-Aymar, Ethel; Sans-Corrales, Mireia; Sant-Arderiu, Elisenda; Cayuelas-Redondo, Laia; Martínez-Pérez, Angela; García-Plana, Noemí; Anguita-Guimet, August; Benavent-Àreu, Jaume title: Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona date: 2020-08-21 journal: PLoS One DOI: 10.1371/journal.pone.0237960 sha: doc_id: 329727 cord_uid: h47q76y8 file: cache/cord-329741-604gtqx9.json key: cord-329741-604gtqx9 authors: Tombetti, Enrico; Mulè, Alice; Tamanini, Silvia; Matteucci, Luca; Negro, Enrica; Brucato, Antonio; Carnovale, Carla title: Novel Pharmacotherapies for Recurrent Pericarditis: Current Options in 2020 date: 2020-06-19 journal: Curr Cardiol Rep DOI: 10.1007/s11886-020-01308-y sha: doc_id: 329741 cord_uid: 604gtqx9 file: cache/cord-329766-9bwdb6o2.json key: cord-329766-9bwdb6o2 authors: Liu, Xiaofan; Zhou, Hong; Zhou, Yilu; Wu, Xiaojun; Zhao, Yang; Lu, Yang; Tan, Weijun; Yuan, Mingli; Ding, Xuhong; Zou, Jinjing; Li, Ruiyun; Liu, Hailing; Ewing, Rob M.; Hu, Yi; Nie, Hanxiang; Wang, Yihua title: Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance date: 2020-06-24 journal: Sci Rep DOI: 10.1038/s41598-020-66895-w sha: doc_id: 329766 cord_uid: 9bwdb6o2 file: cache/cord-329863-r2vqsg5r.json key: cord-329863-r2vqsg5r authors: Salamanna, Francesca; Landini, Maria Paola; Fini, Milena title: Overt and non-overt disseminated intravascular coagulation and the potential role of heparin in the COVID-19 pandemic outbreak date: 2020-10-16 journal: Ther Adv Hematol DOI: 10.1177/2040620720951655 sha: doc_id: 329863 cord_uid: r2vqsg5r file: cache/cord-329877-vish6v8e.json key: cord-329877-vish6v8e authors: Lapinsky, Stephen E.; Hawryluck, Laura title: ICU management of severe acute respiratory syndrome date: 2003-05-09 journal: Intensive Care Med DOI: 10.1007/s00134-003-1821-0 sha: doc_id: 329877 cord_uid: vish6v8e file: cache/cord-330050-05nnihst.json key: cord-330050-05nnihst authors: Li, Yang; Zeng, Ling; Li, Zhanfei; Mao, Qingxiang; Liu, Ding; Zhang, Letian; Zhang, Huayu; Xie, Yu; Liu, Guo; Gan, Xiaoqin; Yang, Fan; Zhou, Siru; Ai, Shanmu; Tang, Hao; Zhong, Qiu; Lu, Hongxiang; Zhang, Huacai; Talmy, Tomer; Zhang, Weiguo; Chen, Liyong; Bai, Xiangjun; Jiang, Jianxin; Zhang, Lianyang title: Emergency trauma care during the outbreak of corona virus disease 2019 (COVID-19) in China date: 2020-05-15 journal: World J Emerg Surg DOI: 10.1186/s13017-020-00312-5 sha: doc_id: 330050 cord_uid: 05nnihst file: cache/cord-330061-q4xi260z.json key: cord-330061-q4xi260z authors: Ferreira, João Guimarães; Rapparini, Cristiane; Gomes, Bruno Moreno; Pinto, Luiz Alexandre Cabral; Freire, Mário Sérgio da Silva e title: Pneumothorax as a late complication of COVID-19 date: 2020-08-31 journal: Revista do Instituto de Medicina Tropical de Sao Paulo DOI: 10.1590/s1678-9946202062061 sha: doc_id: 330061 cord_uid: q4xi260z file: cache/cord-330368-rk31cwl4.json key: cord-330368-rk31cwl4 authors: Bowden, Kasey; Burnham, Ellen L.; Keniston, Angela; Levin, Dimitriy; Limes, Julia; Persoff, Jason; Thurman, Lindsay; Burden, Marisha title: Harnessing the Power of Hospitalists in Operational Disaster Planning: COVID-19 date: 2020-07-13 journal: J Gen Intern Med DOI: 10.1007/s11606-020-05952-6 sha: doc_id: 330368 cord_uid: rk31cwl4 file: cache/cord-330431-9txstz4n.json key: cord-330431-9txstz4n authors: Nomikos, Iakovos N title: What Else but Covid-19 Pandemic? Lessons Learned date: 2020-07-11 journal: Hell Cheirourgike DOI: 10.1007/s13126-020-0544-9 sha: doc_id: 330431 cord_uid: 9txstz4n file: cache/cord-330492-kbob8z48.json key: cord-330492-kbob8z48 authors: Vervoort, Dominique; Luc, Jessica G.Y.; Percy, Edward; Hirji, Sameer; Lee, Richard title: Assessing the Collateral Damage of the Novel Coronavirus: A Call to Action for the Post-COVID-19 Era date: 2020-04-30 journal: Ann Thorac Surg DOI: 10.1016/j.athoracsur.2020.04.015 sha: doc_id: 330492 cord_uid: kbob8z48 file: cache/cord-330655-crfj5adf.json key: cord-330655-crfj5adf authors: Haider, Asim; Siddiqa, Ayesha; Ali, Nisha; Dhallu, Manjeet title: COVID-19 and the Brain: Acute Encephalitis as a Clinical Manifestation date: 2020-10-03 journal: Cureus DOI: 10.7759/cureus.10784 sha: doc_id: 330655 cord_uid: crfj5adf file: cache/cord-330666-puhijixa.json key: cord-330666-puhijixa authors: Carrico, Ruth M.; Coty, Mary B.; Goss, Linda K.; LaJoie, Andrew S. title: Changing health care worker behavior in relation to respiratory disease transmission with a novel training approach that uses biosimulation date: 2007-02-02 journal: Am J Infect Control DOI: 10.1016/j.ajic.2005.12.013 sha: doc_id: 330666 cord_uid: puhijixa file: cache/cord-330676-urr9oqfc.json key: cord-330676-urr9oqfc authors: Keny, Dr Swapnil; Bagaria, Dr Vaibhav; Chaudhary, Dr Kshitij; Dhawale, Dr Arjun title: Emergency and Urgent Orthopaedic Surgeries in non covid patients during the COVID 19 pandemic: Perspective from India date: 2020-05-12 journal: J Orthop DOI: 10.1016/j.jor.2020.05.012 sha: doc_id: 330676 cord_uid: urr9oqfc file: cache/cord-330597-nftwj0d5.json key: cord-330597-nftwj0d5 authors: Hopfer, Helmut; Herzig, Martin C.; Gosert, Rainer; Menter, Thomas; Hench, Jürgen; Tzankov, Alexandar; Hirsch, Hans H.; Miller, Sara E. title: Hunting coronavirus by transmission electron microscopy – a guide to SARS‐CoV‐2‐associated ultrastructural pathology in COVID‐19 tissues date: 2020-09-27 journal: Histopathology DOI: 10.1111/his.14264 sha: doc_id: 330597 cord_uid: nftwj0d5 file: cache/cord-330136-o8df8szx.json key: cord-330136-o8df8szx authors: Fan, Hua; Zhang, Lin; Huang, Bin; Zhu, Muxin; Zhou, Yong; Zhang, Huan; Tao, Xiaogen; Cheng, Shaohui; Yu, Wenhu; Zhu, Liping; Chen, Jian title: Cardiac injuries in patients with coronavirus disease 2019: Not to be ignored date: 2020-05-11 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.05.024 sha: doc_id: 330136 cord_uid: o8df8szx file: cache/cord-330359-c0l5xq5m.json key: cord-330359-c0l5xq5m authors: Curran, J; Calder, N; Yaneza, M; Iyer, A title: Reducing potential aerosol generation in flexible nasolaryngoscopy: a novel method date: 2020-07-09 journal: The Journal of laryngology and otology DOI: 10.1017/s0022215120001413 sha: doc_id: 330359 cord_uid: c0l5xq5m file: cache/cord-330831-3b7vfv9b.json key: cord-330831-3b7vfv9b authors: Hao, Fengyi; Tam, Wilson; Hu, Xiaoyu; Tan, Wanqiu; Jiang, Li; Jiang, Xiaojiang; Zhang, Ling; Zhao, Xinling; Zou, Yiran; Hu, Yirong; Luo, Xi; McIntyre, Roger S.; Quek, Travis; Tran, Bach Xuan; Zhang, Zhisong; Pham, Hai Quang; Ho, Cyrus S. H.; Ho, Roger C.M. title: A quantitative and qualitative study on the neuropsychiatric sequelae of acutely ill COVID-19 inpatients in isolation facilities date: 2020-10-19 journal: Transl Psychiatry DOI: 10.1038/s41398-020-01039-2 sha: doc_id: 330831 cord_uid: 3b7vfv9b file: cache/cord-329985-5rji08p7.json key: cord-329985-5rji08p7 authors: Robba, Chiara; Robba, Chiara; Battaglini, Denise; Ball, Lorenzo; Patroniti, Nicolo’; Loconte, Maurizio; Brunetti, Iole; Vena, Antonio; Giacobbe, Daniele; Bassetti, Matteo; Rocco, Patricia Rieken Macedo; Pelosi, Paolo title: Distinct phenotypes require distinct respiratory management strategies in severe COVID-19 date: 2020-05-11 journal: Respir Physiol Neurobiol DOI: 10.1016/j.resp.2020.103455 sha: doc_id: 329985 cord_uid: 5rji08p7 file: cache/cord-330701-k68b0wqe.json key: cord-330701-k68b0wqe authors: Gerc, Vjekoslav; Masic, Izet; Salihefendic, Nizama; Zildzic, Muharem title: Cardiovascular Diseases (CVDs) in COVID-19 Pandemic Era date: 2020-06-17 journal: Mater Sociomed DOI: 10.5455/msm.2020.32.158-164 sha: doc_id: 330701 cord_uid: k68b0wqe file: cache/cord-329856-0m5mc320.json key: cord-329856-0m5mc320 authors: Ahmad, Shandar title: Potential of age distribution profiles for the prediction of COVID-19 infection origin in a patient group date: 2020-06-04 journal: Inform Med Unlocked DOI: 10.1016/j.imu.2020.100364 sha: doc_id: 329856 cord_uid: 0m5mc320 file: cache/cord-330869-k5ro0edf.json key: cord-330869-k5ro0edf authors: Kumar Singh, Awadhesh; Khunti, Kamlesh title: Assessment of risk, severity, mortality, glycemic control and antidiabetic agents in patients with diabetes and COVID-19: A Narrative Review date: 2020-06-11 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108266 sha: doc_id: 330869 cord_uid: k5ro0edf file: cache/cord-330369-75cotmn2.json key: cord-330369-75cotmn2 authors: López, Verónica; Vázquez, Teresa; Alonso-Titos, Juana; Cabello, Mercedes; Alonso, Angel; Beneyto, Isabel; Crespo, Marta; Díaz-Corte, Carmen; Franco, Antonio; González-Roncero, Francisco; Gutiérrez, Elena; Guirado, Luis; Jiménez, Carlos; Jironda, Cristina; Lauzurica, Ricardo; Llorente, Santiago; Mazuecos, Auxiliadora; Paul, Javier; Rodríguez-Benot, Alberto; Ruiz, Juan Carlos; Sánchez-Fructuoso, Ana; Sola, Eugenia; Torregrosa, Vicente; Zárraga, Sofía; Hernández, Domingo title: Recommendations on management of the SARS-CoV-2 coronavirus pandemic (Covid-19) in kidney transplant patients date: 2020-04-06 journal: nan DOI: 10.1016/j.nefroe.2020.03.017 sha: doc_id: 330369 cord_uid: 75cotmn2 file: cache/cord-330573-rr2r8245.json key: cord-330573-rr2r8245 authors: Stockmann, Helena; Keller, Theresa; Büttner, Stefan; Jörres, Achim; Kindgen-Milles, Detlef; Kunz, Julius Valentin; Leebmann, Josef; Spies, Claudia; Träger, Karl; Treskatsch, Sascha; Uhrig, Alexander; Willam, Carsten; Enghard, Philipp; Slowinski, Torsten title: CytoResc – “CytoSorb” Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial date: 2020-06-26 journal: Trials DOI: 10.1186/s13063-020-04501-0 sha: doc_id: 330573 cord_uid: rr2r8245 file: cache/cord-330856-j1wqrc8v.json key: cord-330856-j1wqrc8v authors: Matoori, Simon; Khurana, Bharti; Balcom, Marta Chadwick; Froehlich, Johannes M.; Janssen, Sonja; Forstner, Rosemarie; King, Ann D.; Koh, Dow-Mu; Gutzeit, Andreas title: Addressing intimate partner violence during the COVID-19 pandemic and beyond: how radiologists can make a difference date: 2020-10-06 journal: Eur Radiol DOI: 10.1007/s00330-020-07332-4 sha: doc_id: 330856 cord_uid: j1wqrc8v file: cache/cord-329989-176cvimy.json key: cord-329989-176cvimy authors: Federico, Antonio title: Scientific publishing in the COVID-19 era: successes and pitfalls date: 2020-07-02 journal: Neurol Sci DOI: 10.1007/s10072-020-04550-y sha: doc_id: 329989 cord_uid: 176cvimy file: cache/cord-331109-a8e7r80d.json key: cord-331109-a8e7r80d authors: Ibrahim, Yassmin S.; Karuppasamy, Gowri; Parambil, Jessiya V.; Alsoub, Hussam; Al-Shokri, Shaikha D. title: Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19 date: 2020-08-31 journal: Am J Trop Med Hyg DOI: 10.4269/ajtmh.20-0894 sha: doc_id: 331109 cord_uid: a8e7r80d file: cache/cord-330963-w24q8sn7.json key: cord-330963-w24q8sn7 authors: Langston, Amelia A.; Quest, Tammie E.; Abernethy, Eli Rowe; Campbell, Gavin Paul; Owonikoko, Taofeek K.; Pentz, Rebecca D. title: Allocating Scarce Healthcare Resources during Pandemics: Making the Case for Patients with Advanced and Metastatic Cancer date: 2020-08-03 journal: Oncologist DOI: 10.1634/theoncologist.2020-0442 sha: doc_id: 330963 cord_uid: w24q8sn7 file: cache/cord-331317-q01uos7a.json key: cord-331317-q01uos7a authors: Suh, Gee Young; Kang, Eun Hae; Chung, Man Pyo; Lee, Kyung Soo; Han, Joungho; Kitaichi, Masanori; Kwon, O Jung title: Early Intervention Can Improve Clinical Outcome of Acute Interstitial Pneumonia date: 2015-12-30 journal: Chest DOI: 10.1378/chest.129.3.753 sha: doc_id: 331317 cord_uid: q01uos7a file: cache/cord-331114-lumfg138.json key: cord-331114-lumfg138 authors: Berkman, Samuel A; Tapson, Victor F title: Methodological Issues and Controversies in COVID-19 Coagulopathy: A Tale of Two Storms date: 2020-09-03 journal: Clin Appl Thromb Hemost DOI: 10.1177/1076029620945398 sha: doc_id: 331114 cord_uid: lumfg138 file: cache/cord-331273-1fixwxuo.json key: cord-331273-1fixwxuo authors: Abejón González, David; Monzón, Eva M; Deer, Tim; Hagedorn, Jonathan M.; Araujo, Ricardo; Abad, Cristina; Rios, Alberto; Zamora, Alejandro; Vallejo, Ricardo title: How to restart the interventional activity in the COVID‐19 era. The experience of a private Pain Unit in Spain date: 2020-09-23 journal: Pain Pract DOI: 10.1111/papr.12951 sha: doc_id: 331273 cord_uid: 1fixwxuo file: cache/cord-331434-2x9m37cw.json key: cord-331434-2x9m37cw authors: Kumar Jain, Vijay; Lal, Hitesh; Kumar Patralekh, Mohit; Vaishya, Raju title: Fracture management during COVID-19 pandemic: A systematic review and meta-analysis date: 2020-06-30 journal: J Clin Orthop Trauma DOI: 10.1016/j.jcot.2020.06.035 sha: doc_id: 331434 cord_uid: 2x9m37cw file: cache/cord-331268-kzy33hdb.json key: cord-331268-kzy33hdb authors: Lynch, Sharon G.; Rose, John W. title: Multiple sclerosis date: 1996-01-31 journal: Disease-a-Month DOI: 10.1016/s0011-5029(96)90012-7 sha: doc_id: 331268 cord_uid: kzy33hdb file: cache/cord-330870-l0ryikhv.json key: cord-330870-l0ryikhv authors: Eubanks, Allison; Thomson, Brook; Marko, Emily; Auguste, Tamika; Peterson, Logan; Goffman, Dena; Deering, Shad title: Obstetric Simulation for a Pandemic date: 2020-07-23 journal: Semin Perinatol DOI: 10.1016/j.semperi.2020.151294 sha: doc_id: 330870 cord_uid: l0ryikhv file: cache/cord-331449-0sow1im8.json key: cord-331449-0sow1im8 authors: Saha, Shivangi; Kumar, Aditya; Dash, Suvashis; Singhal, Maneesh title: Managing Burns During COVID-19 Outbreak date: 2020-05-30 journal: J Burn Care Res DOI: 10.1093/jbcr/iraa086 sha: doc_id: 331449 cord_uid: 0sow1im8 file: cache/cord-330877-nsx4b4rm.json key: cord-330877-nsx4b4rm authors: Elcioglu, Omer Celal; Artan, Ayse Serra; Mirioglu, Safak; Gursu, Meltem; Durdu, Bulent; Meric Koc, Meliha; Okyaltirik, Fatmanur; Gultekin, Mehmet Ali; Kazancioglu, Rumeyza title: COVİD-19 infection in a membranous nephropathy patient treated with rituximab date: 2020-09-04 journal: CEN Case Rep DOI: 10.1007/s13730-020-00524-3 sha: doc_id: 330877 cord_uid: nsx4b4rm file: cache/cord-330918-hsy8h1vb.json key: cord-330918-hsy8h1vb authors: Song, Jia; Hu, Weihang; Yu, Yihua; Shen, Xin; Wang, Yueben; Yan, Jing; Yang, Xianghong; Gong, Shijin; Wang, Minjia title: A Comparison of Clinical Characteristics and Outcomes in Elderly and Younger Patients with COVID-19 date: 2020-07-28 journal: Med Sci Monit DOI: 10.12659/msm.925047 sha: doc_id: 330918 cord_uid: hsy8h1vb file: cache/cord-331270-12zx0o2p.json key: cord-331270-12zx0o2p authors: Rico, Timóteo Matthies; dos Santos Machado, Karina; Fernandes, Vanessa Pellegrini; Madruga, Samanta Winck; Santin, Mateus Madail; Petrarca, Cristiane Rios; Dumith, Samuel Carvalho title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial date: 2020-09-30 journal: J Med Syst DOI: 10.1007/s10916-020-01663-x sha: doc_id: 331270 cord_uid: 12zx0o2p file: cache/cord-331487-jh34klbg.json key: cord-331487-jh34klbg authors: Sivapalan, Pradeesh; Ulrik, Charlotte Suppli; Bojesen, Rasmus Dahlin; Lapperre, Therese Sophie; Eklöf, Josefin Viktoria; Håkansson, Kjell Erik Julius; Browatzki, Andrea; Tidemansen, Casper; Wilcke, Jon Torgny; Janner, Julie; Gottlieb, Vibeke; Meteran, Howraman; Porsbjerg, Celeste; Madsen, Birgitte Lindegaard; Moberg, Mia; Pedersen, Lars; Benfield, Thomas Lars; Lundgren, Jens Dilling; Knop, Filip Krag; Biering-Sørensen, Tor; Ghanizada, Muzhda; Sonne, Tine Peick; Bødtger, Uffe Christian Steinholtz; Jensen, Sidse Graff; Rasmussen, Daniel Bech; Brøndum, Eva; Tupper, Oliver Djurhuus; Sørensen, Susanne Wiemann; Alstrup, Gitte; Laursen, Christian Borbjerg; Møller, Ulla Weinrich; Sverrild, Asger; Jensen, Jens-Ulrik Stæhr title: Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-10 journal: Trials DOI: 10.1186/s13063-020-04409-9 sha: doc_id: 331487 cord_uid: jh34klbg file: cache/cord-331481-zeaqi1uc.json key: cord-331481-zeaqi1uc authors: Al-Ani, Fatimah; Chehade, Samer; Lazo-Langner, Alejandro title: Thrombosis risk associated with COVID-19 infection. A scoping review date: 2020-05-27 journal: Thromb Res DOI: 10.1016/j.thromres.2020.05.039 sha: doc_id: 331481 cord_uid: zeaqi1uc file: cache/cord-331452-y5lhawqo.json key: cord-331452-y5lhawqo authors: Lentz, Skyler; Grossman, Alexandra; Koyfman, Alex; Long, Brit title: High-Risk Airway Management in the Emergency Department: Diseases and Approaches Part I date: 2020-05-12 journal: J Emerg Med DOI: 10.1016/j.jemermed.2020.05.008 sha: doc_id: 331452 cord_uid: y5lhawqo file: cache/cord-331165-2yn1n3eq.json key: cord-331165-2yn1n3eq authors: Tauben, David J.; Langford, Dale J.; Sturgeon, John A.; Rundell, Sean D.; Towle, Cara; Bockman, Christina; Nicholas, Michael title: Optimizing telehealth pain care after COVID-19 date: 2020-08-20 journal: Pain DOI: 10.1097/j.pain.0000000000002048 sha: doc_id: 331165 cord_uid: 2yn1n3eq file: cache/cord-331519-ye4dtna5.json key: cord-331519-ye4dtna5 authors: Garibaldi, B. T.; Fiksel, J.; Muschelli, J.; Robinson, M. L.; Rouhizadeh, M.; Nagy, P.; Gray, J. H.; Malapati, H.; Ghobadi-Krueger, M.; Niessen, T. M.; Kim, B. S.; Hill, P. M.; Ahmed, M. S.; Dobkin, E. D.; Blanding, R.; Abele, J.; Woods, B.; Harkness, K.; Thiemann, D. R.; Bowring, M. G.; Shah, A. B.; Wang, M. C.; Bandeen-Roche, K.; Rosen, A.; Zeger, S. L.; Gupta, A. title: Patient trajectories and risk factors for severe outcomes among persons hospitalized for COVID-19 in the Maryland/DC region date: 2020-05-26 journal: nan DOI: 10.1101/2020.05.24.20111864 sha: doc_id: 331519 cord_uid: ye4dtna5 file: cache/cord-331533-0toegbv8.json key: cord-331533-0toegbv8 authors: Leiker, Brenna; Wise, Katherine title: COVID – 19 CASE STUDY IN EMERGENCY MEDICINE PREPAREDNESS AND RESPONSE; FROM PERSONAL PROTECTIVE EQUIPMENT TO DELIVERGY OF CARE date: 2020-07-27 journal: Dis Mon DOI: 10.1016/j.disamonth.2020.101060 sha: doc_id: 331533 cord_uid: 0toegbv8 file: cache/cord-331547-uqmjhhna.json key: cord-331547-uqmjhhna authors: Bonalumi, Giorgia; Giambuzzi, Ilaria; Barbone, Alessandro; Ranieri, Camilla; Cavallotti, Laura; Trabattoni, Piero; Naliato, Moreno; Polvani, Gianluca; Torracca, Lucia; Pelenghi, Stefano; Ragni, Franco; Russo, Claudio Francesco; Guerra, Francisco; Trimarchi, Santi; Civilini, Efrem; Romani, Federico; Bellosta, Raffaello; Losa, Sergio; Roberto, Maurizio; Alamanni, Francesco title: A call to action becomes practice: cardiac and vascular surgery during the COVID-19 pandemic based on the Lombardy emergency guidelines date: 2020-06-25 journal: Eur J Cardiothorac Surg DOI: 10.1093/ejcts/ezaa204 sha: doc_id: 331547 cord_uid: uqmjhhna file: cache/cord-331762-b0yufidn.json key: cord-331762-b0yufidn authors: Rudski, Lawrence; Januzzi, James L.; Rigolin, Vera H.; Bohula, Erin A.; Blankstein, Ron; Patel, Amit R.; Bucciarelli-Ducci, Chiara; Vorovich, Esther; Mukherjee, Monica; Rao, Sunil V.; Beanlands, Rob; Villines, Todd C.; Di Carli, Marcelo F. title: Multimodality Imaging in Evaluation of Cardiovascular complications in Patients with COVID-19 date: 2020-07-22 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2020.06.080 sha: doc_id: 331762 cord_uid: b0yufidn file: cache/cord-331500-l3hkn2li.json key: cord-331500-l3hkn2li authors: Luyt, Charles-Edouard; Bouadma, Lila; Morris, Andrew Conway; Dhanani, Jayesh A.; Kollef, Marin; Lipman, Jeffrey; Martin-Loeches, Ignacio; Nseir, Saad; Ranzani, Otavio T.; Roquilly, Antoine; Schmidt, Matthieu; Torres, Antoni; Timsit, Jean-François title: Pulmonary infections complicating ARDS date: 2020-11-11 journal: Intensive Care Med DOI: 10.1007/s00134-020-06292-z sha: doc_id: 331500 cord_uid: l3hkn2li file: cache/cord-331604-jf6ybip5.json key: cord-331604-jf6ybip5 authors: Moratto, Daniele; Chiarini, Marco; Giustini, Viviana; Serana, Federico; Magro, Paola; Roccaro, Aldo Maria; Imberti, Luisa; Castelli, Francesco; Notarangelo, Luigi Daniele; Quiros-Roldan, Eugenia title: Flow Cytometry Identifies Risk Factors and Dynamic Changes in Patients with COVID-19 date: 2020-06-27 journal: J Clin Immunol DOI: 10.1007/s10875-020-00806-6 sha: doc_id: 331604 cord_uid: jf6ybip5 file: cache/cord-332036-op6s8tr4.json key: cord-332036-op6s8tr4 authors: Feldman, Candace H.; Ramsey‐Goldman, Rosalind title: Widening Disparities Among Patients with Rheumatic Diseases in the COVID‐19 Era: An Urgent Call to Action date: 2020-05-07 journal: Arthritis Rheumatol DOI: 10.1002/art.41306 sha: doc_id: 332036 cord_uid: op6s8tr4 file: cache/cord-331827-amg309uz.json key: cord-331827-amg309uz authors: Keske, Şiran; Gümüş, Terman; Köymen, Tamer; Sandıkçı, Sunay; Tabak, Levet; Ergönül, Önder title: Human metapneumovirus infection: Diagnostic impact of radiologic imaging date: 2019-02-01 journal: J Med Virol DOI: 10.1002/jmv.25402 sha: doc_id: 331827 cord_uid: amg309uz file: cache/cord-331915-7idktu7c.json key: cord-331915-7idktu7c authors: Cieslak, Theodore J; Kortepeter, Mark G title: A Brief History of Biocontainment date: 2016-10-20 journal: Curr Treat Options Infect Dis DOI: 10.1007/s40506-016-0096-2 sha: doc_id: 331915 cord_uid: 7idktu7c file: cache/cord-332013-bl5d4xkc.json key: cord-332013-bl5d4xkc authors: Sánchez-Álvarez, J. Emilio; Fontán, Miguel Pérez; Martín, Carlos Jiménez; Pelícano, Miquel Blasco; Reina, Carlos Jesús Cabezas; Prieto, Ángel M. Sevillano; Melilli, Edoardo; Barrios, Marta Crespo; Heras, Manuel Macía; Pino, María D o lores del Pino y title: Status of SARS-CoV-2 infection in patients on renal replacement therapy Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN) date: 2020-04-27 journal: nan DOI: 10.1016/j.nefroe.2020.04.002 sha: doc_id: 332013 cord_uid: bl5d4xkc file: cache/cord-332145-rw16o02g.json key: cord-332145-rw16o02g authors: Chen, Patrick M.; Hemmen, Thomas M. title: Evolving Healthcare Delivery in Neurology During the Coronavirus Disease 2019 (COVID-19) Pandemic date: 2020-05-29 journal: Front Neurol DOI: 10.3389/fneur.2020.00578 sha: doc_id: 332145 cord_uid: rw16o02g file: cache/cord-332153-fczf3lzc.json key: cord-332153-fczf3lzc authors: Azkur, Ahmet Kursat; Akdis, Mübeccel; Azkur, Dilek; Sokolowska, Milena; van de Veen, Willem; Brüggen, Marie‐Charlotte; O'Mahony, Liam; Gao, Yadong; Nadeau, Kari; Akdis, Cezmi A. title: Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19 date: 2020-05-12 journal: Allergy DOI: 10.1111/all.14364 sha: doc_id: 332153 cord_uid: fczf3lzc file: cache/cord-332709-0plblo4k.json key: cord-332709-0plblo4k authors: Zodda, David; Hanson, Allyson; Berns, Alyssa title: Optimizing Non-invasive Oxygenation for COVID-19 Patients Presenting to the Emergency Department with Acute Respiratory Distress: A Case Report date: 2020-06-22 journal: Clin Pract Cases Emerg Med DOI: 10.5811/cpcem.2020.6.48456 sha: doc_id: 332709 cord_uid: 0plblo4k file: cache/cord-332087-xwturwju.json key: cord-332087-xwturwju authors: McGlynn, Fergal; McGrath, Jennifer; Varghese, Chithra; Ryan, Barbara; McHugh, Johnny; Fahy, Arabella; Enright, Helen title: Argatroban for therapeutic anticoagulation for heparin resistance associated with Covid-19 infection date: 2020-08-24 journal: J Thromb Thrombolysis DOI: 10.1007/s11239-020-02251-z sha: doc_id: 332087 cord_uid: xwturwju file: cache/cord-332233-01rdlf8l.json key: cord-332233-01rdlf8l authors: Tully, Thomas N. title: CHAPTER 12 MICE AND RATS date: 2009-12-31 journal: Manual of Exotic Pet Practice DOI: 10.1016/b978-141600119-5.50015-9 sha: doc_id: 332233 cord_uid: 01rdlf8l file: cache/cord-333340-ekok0mp5.json key: cord-333340-ekok0mp5 authors: Graf, Erin H.; Pancholi, Preeti title: Appropriate Use and Future Directions of Molecular Diagnostic Testing date: 2020-02-06 journal: Curr Infect Dis Rep DOI: 10.1007/s11908-020-0714-5 sha: doc_id: 333340 cord_uid: ekok0mp5 file: cache/cord-333588-3krh1xzx.json key: cord-333588-3krh1xzx authors: Sharma, Amita; Jain, Megha B title: Pediatric Dentistry during Coronavirus Disease-2019 Pandemic: A Paradigm Shift in Treatment Options date: 2020 journal: Int J Clin Pediatr Dent DOI: 10.5005/jp-journals-10005-1809 sha: doc_id: 333588 cord_uid: 3krh1xzx file: cache/cord-333470-0a0i6vjn.json key: cord-333470-0a0i6vjn authors: Lombe, Dorothy C; Mwaba, Catherine K; Msadabwe, Susan C; Banda, Lewis; Mwale, Maurice; Pupwe, George; Kamfwa, Paul; Kanduza, Mulape; Munkupa, Harry; Maliti, Biemba; Simbeye, Kalyoka; Hachizo, Pious; Lin, Lilie; Chiao, Elizabeth; Lishimpi, Kennedy title: Zambia’s National Cancer Centre response to the COVID-19 pandemic—an opportunity for improved care date: 2020-05-28 journal: Ecancermedicalscience DOI: 10.3332/ecancer.2020.1051 sha: doc_id: 333470 cord_uid: 0a0i6vjn file: cache/cord-332150-j76726no.json key: cord-332150-j76726no authors: De Stefano, Ludovico; Bobbio-Pallavicini, Francesca; Manzo, Antonio; Montecucco, Carlomaurizio; Bugatti, Serena title: A “Window of Therapeutic Opportunity” for Anti-Cytokine Therapy in Patients With Coronavirus Disease 2019 date: 2020-10-06 journal: Front Immunol DOI: 10.3389/fimmu.2020.572635 sha: doc_id: 332150 cord_uid: j76726no file: cache/cord-332278-2p64ab2z.json key: cord-332278-2p64ab2z authors: Vivas, David; Roldán, Vanessa; Esteve-Pastor, María Asunción; Roldán, Inmaculada; Tello-Montoliu, Antonio; Ruiz-Nodar, Juan Miguel; Cosín-Sales, Juan; María Gámez, José; Consuegra, Luciano; Luis Ferreiro, José; Marín, Francisco title: Recomendaciones sobre el tratamiento antitrombótico durante la pandemia COVID-19. Posicionamiento del Grupo de Trabajo de Trombosis Cardiovascular de la Sociedad Española de Cardiología date: 2020-06-19 journal: Rev Esp Cardiol (Engl Ed) DOI: 10.1016/j.rec.2020.04.025 sha: doc_id: 332278 cord_uid: 2p64ab2z file: cache/cord-332861-7b5pzmk6.json key: cord-332861-7b5pzmk6 authors: Zhang, Zhan; Li, Xiaochen; Zhang, Wei; Shi, Zheng-Li; Zheng, Zhishui; Wang, Tao title: Clinical Features and Treatment of 2019-nCov Pneumonia Patients in Wuhan: Report of A Couple Cases date: 2020-02-07 journal: Virol Sin DOI: 10.1007/s12250-020-00203-8 sha: doc_id: 332861 cord_uid: 7b5pzmk6 file: cache/cord-333451-p2plpeew.json key: cord-333451-p2plpeew authors: Raab, Anja M.; Michel, Franz title: Significant demands on healthcare resources during the COVID crisis date: 2020-05-13 journal: Spinal Cord DOI: 10.1038/s41393-020-0482-y sha: doc_id: 333451 cord_uid: p2plpeew file: cache/cord-334524-8uqnlpvc.json key: cord-334524-8uqnlpvc authors: Johannson, Kerri A. title: Remote Monitoring in Idiopathic Pulmonary Fibrosis: Home Is Where the Bluetooth-enabled Spirometer Is date: 2020-08-01 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202005-1532ed sha: doc_id: 334524 cord_uid: 8uqnlpvc file: cache/cord-333113-0k6xlmem.json key: cord-333113-0k6xlmem authors: Tran, V.-T.; Mahevas, M.; Bani Sadr, F.; Robineau, O.; Perpoint, T.; Perrodeau, E.; Gallay, L.; Ravaud, P.; Goehringer, F.; Lescure, X.; COCORICO, title: Association between corticosteroids and intubation or death among patients with COVID-19 pneumonia in non-ICU settings: an observational study using of real-world data from 51 hospitals in France and Luxembourg date: 2020-09-18 journal: nan DOI: 10.1101/2020.09.16.20195750 sha: doc_id: 333113 cord_uid: 0k6xlmem file: cache/cord-334367-w96iqo6q.json key: cord-334367-w96iqo6q authors: Devlin, John W.; O’Neal, Hollis R.; Thomas, Christopher; Barnes Daly, Mary Ann; Stollings, Joanna L.; Janz, David R.; Ely, E. Wesley; Lin, John C. title: Strategies to Optimize ICU Liberation (A to F) Bundle Performance in Critically Ill Adults With Coronavirus Disease 2019 date: 2020-06-12 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000139 sha: doc_id: 334367 cord_uid: w96iqo6q file: cache/cord-333816-cznwzcn9.json key: cord-333816-cznwzcn9 authors: Chung, Michael; Bernheim, Adam; Mei, Xueyan; Zhang, Ning; Huang, Mingqian; Zeng, Xianjun; Cui, Jiufa; Xu, Wenjian; Yang, Yang; Fayad, Zahi A.; Jacobi, Adam; Li, Kunwei; Li, Shaolin; Shan, Hong title: CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) date: 2020-02-04 journal: Radiology DOI: 10.1148/radiol.2020200230 sha: doc_id: 333816 cord_uid: cznwzcn9 file: cache/cord-332055-lrpfzsog.json key: cord-332055-lrpfzsog authors: DeVos, Elizabeth; Jacobson, Lisa title: Approach to Adult Patients with Acute Dyspnea date: 2015-11-27 journal: Emerg Med Clin North Am DOI: 10.1016/j.emc.2015.08.008 sha: doc_id: 332055 cord_uid: lrpfzsog file: cache/cord-333453-v3gap8kj.json key: cord-333453-v3gap8kj authors: Dima, Mirabela; Enatescu, Ileana; Craina, Marius; Petre, Izabella; Iacob, Emil Radu; Iacob, Daniela title: First neonates with severe acute respiratory syndrome coronavirus 2 infection in Romania: Three case reports date: 2020-08-14 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000021284 sha: doc_id: 333453 cord_uid: v3gap8kj file: cache/cord-332180-dw4h69tp.json key: cord-332180-dw4h69tp authors: Cheng, Fu-Yuan; Joshi, Himanshu; Tandon, Pranai; Freeman, Robert; Reich, David L; Mazumdar, Madhu; Kohli-Seth, Roopa; Levin, Matthew A.; Timsina, Prem; Kia, Arash title: Using Machine Learning to Predict ICU Transfer in Hospitalized COVID-19 Patients date: 2020-06-01 journal: J Clin Med DOI: 10.3390/jcm9061668 sha: doc_id: 332180 cord_uid: dw4h69tp file: cache/cord-334324-remrcm2q.json key: cord-334324-remrcm2q authors: Kunal, Shekhar; Sharma, Shashi Mohan; Sharma, Sohan Kumar; Gautam, Dinesh; Bhatia, Harnish; Mahla, Himanshu; Sharma, Sandeep; Bhandari, Sudhir title: Cardiovascular complications and its impact on outcomes in COVID-19 date: 2020-11-04 journal: Indian Heart J DOI: 10.1016/j.ihj.2020.10.005 sha: doc_id: 334324 cord_uid: remrcm2q file: cache/cord-332788-8lq9qygn.json key: cord-332788-8lq9qygn authors: Manda, Sudhir; Yimer, Habte A.; Noga, Stephen J.; Girnius, Saulius; Yasenchak, Christopher A.; Charu, Veena; Lyons, Roger; Aiello, Jack; Bogard, Kimberly; Ferrari, Renda H.; Cherepanov, Dasha; Demers, Brittany; Lu, Vickie; Whidden, Presley; Kambhampati, Suman; Birhiray, Ruemu E.; Jhangiani, Haresh S.; Boccia, Ralph; Rifkin, Robert M. title: Feasibility of Long-Term Proteasome Inhibition in Multiple Myeloma by In-Class Transition from Bortezomib to Ixazomib date: 2020-07-06 journal: Clin Lymphoma Myeloma Leuk DOI: 10.1016/j.clml.2020.06.024 sha: doc_id: 332788 cord_uid: 8lq9qygn file: cache/cord-334715-902pfxyz.json key: cord-334715-902pfxyz authors: Sirico, Domenico; Castaldi, Biagio; Ciliberti, Paolo; Sabatino, Jolanda; Cazzoli, Ilaria; Secinaro, Aurelio; Calcaterra, Giuseppe; Oreto, Lilia; Calabrò, Maria Pia; Chessa, Massimo; Limongelli, Giuseppe; D’Alto, Michele; Serra, Walter; Bassareo, Pierpaolo; Russo, Maria Giovanna; Guccione, Paolo; Di Salvo, Giovanni title: Cardiac imaging in congenital heart disease during the coronavirus disease-2019 pandemic: recommendations from the Working Group on Congenital Heart Disease of the Italian Society of Cardiology date: 2020-06-01 journal: J Cardiovasc Med (Hagerstown) DOI: 10.2459/jcm.0000000000000990 sha: doc_id: 334715 cord_uid: 902pfxyz file: cache/cord-334790-lav794w0.json key: cord-334790-lav794w0 authors: Jin, Huijuan; Hong, Candong; Chen, Shengcai; Zhou, Yifan; Wang, Yong; Mao, Ling; Li, Yanan; He, Quanwei; Li, Man; Su, Ying; Wang, David; Wang, Longde; Hu, Bo title: Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists date: 2020-04-01 journal: Stroke Vasc Neurol DOI: 10.1136/svn-2020-000382 sha: doc_id: 334790 cord_uid: lav794w0 file: cache/cord-333183-xyuj1j57.json key: cord-333183-xyuj1j57 authors: Lee, Lennard Y W; Cazier, Jean Baptiste; Starkey, T; Turnbull, C D; Kerr, Rachel; Middleton, Gary title: COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study date: 2020-05-28 journal: Lancet DOI: 10.1016/s0140-6736(20)31173-9 sha: doc_id: 333183 cord_uid: xyuj1j57 file: cache/cord-332774-t5untewz.json key: cord-332774-t5untewz authors: Vaccaro, Alexander R.; Getz, Charles L.; Cohen, Bruce E.; Cole, Brian J.; Donnally, Chester J. title: Practice Management During the COVID-19 Pandemic date: 2020-04-13 journal: J Am Acad Orthop Surg DOI: 10.5435/jaaos-d-20-00379 sha: doc_id: 332774 cord_uid: t5untewz file: cache/cord-333429-bq7kfpby.json key: cord-333429-bq7kfpby authors: Shi, Ding; Wu, Wenrui; Wang, Qing; Xu, Kaijin; Xie, Jiaojiao; Wu, Jingjing; Lv, Longxian; Sheng, Jifang; Guo, Jing; Wang, Kaicen; Fang, Daiqiong; Li, Yating; Li, Lanjuan title: Clinical characteristics and factors associated with long-term viral excretion in patients with SARS-CoV-2 infection: a single center 28-day study date: 2020-07-02 journal: J Infect Dis DOI: 10.1093/infdis/jiaa388 sha: doc_id: 333429 cord_uid: bq7kfpby file: cache/cord-333024-1yrmun3z.json key: cord-333024-1yrmun3z authors: von Lilienfeld-Toal, Marie; Berger, Annemarie; Christopeit, Maximilian; Hentrich, Marcus; Heussel, Claus Peter; Kalkreuth, Jana; Klein, Michael; Kochanek, Matthias; Penack, Olaf; Hauf, Elke; Rieger, Christina; Silling, Gerda; Vehreschild, Maria; Weber, Thomas; Wolf, Hans-Heinrich; Lehners, Nicola; Schalk, Enrico; Mayer, Karin title: Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology date: 2016-09-25 journal: Eur J Cancer DOI: 10.1016/j.ejca.2016.08.015 sha: doc_id: 333024 cord_uid: 1yrmun3z file: cache/cord-333696-3ci9re9a.json key: cord-333696-3ci9re9a authors: Alomari, Safwan O.; Abou-Mrad, Zaki; Bydon, Ali title: COVID-19 and the Central Nervous System date: 2020-08-04 journal: Clin Neurol Neurosurg DOI: 10.1016/j.clineuro.2020.106116 sha: doc_id: 333696 cord_uid: 3ci9re9a file: cache/cord-332778-rf47ptj6.json key: cord-332778-rf47ptj6 authors: Vivarelli, Silvia; Falzone, Luca; Grillo, Caterina Maria; Scandurra, Giuseppa; Torino, Francesco; Libra, Massimo title: Cancer Management during COVID-19 Pandemic: Is Immune Checkpoint Inhibitors-Based Immunotherapy Harmful or Beneficial? date: 2020-08-10 journal: Cancers (Basel) DOI: 10.3390/cancers12082237 sha: doc_id: 332778 cord_uid: rf47ptj6 file: cache/cord-332480-3uodkrkp.json key: cord-332480-3uodkrkp authors: Bonam, Srinivasa Reddy; Kaveri, Srini V.; Sakuntabhai, Anavaj; Gilardin, Laurent; Bayry, Jagadeesh title: Adjunct immunotherapies for the management of severely ill COVID-19 patients date: 2020-04-30 journal: Cell reports medicine DOI: 10.1016/j.xcrm.2020.100016 sha: doc_id: 332480 cord_uid: 3uodkrkp file: cache/cord-333375-d7cgvjsm.json key: cord-333375-d7cgvjsm authors: Phoon, Laiyee; Chen, Hao title: Recommendations on diagnosis and treatment in hepatobiliary surgery under 2019-nCoV epidemic date: 2020-06-12 journal: Clin Res Hepatol Gastroenterol DOI: 10.1016/j.clinre.2020.04.021 sha: doc_id: 333375 cord_uid: d7cgvjsm file: cache/cord-334408-w0yxz7zb.json key: cord-334408-w0yxz7zb authors: Rosca, Paola; Shapira, Barak; Neumark, Yehuda title: Isolating the isolated: Implications of COVID-19 quarantine measures on in-patient detoxification treatment for substance use disorders date: 2020-07-06 journal: Int J Drug Policy DOI: 10.1016/j.drugpo.2020.102830 sha: doc_id: 334408 cord_uid: w0yxz7zb file: cache/cord-334092-50r3h7jv.json key: cord-334092-50r3h7jv authors: Loungani, Rahul S.; Rehorn, Michael R.; Newby, L. Kristin; Katz, Jason N.; Klem, Igor; Mentz, Robert J.; Jones, W. Schuyler; Vemulapalli, Sreekanth; Kelsey, Anita M.; Blazing, Michael A.; Piccini, Jonathan P.; Patel, Manesh R. title: A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response date: 2020-05-03 journal: Am Heart J DOI: 10.1016/j.ahj.2020.04.024 sha: doc_id: 334092 cord_uid: 50r3h7jv file: cache/cord-333684-j1sg46w9.json key: cord-333684-j1sg46w9 authors: Filippi, Federica; Loi, Camilla; Evangelista, Valeria; Bardazzi, Federico title: COVID‐19 era: A chance to learn something new about monitoring psoriatic patients in biological therapy date: 2020-06-10 journal: Dermatol Ther DOI: 10.1111/dth.13805 sha: doc_id: 333684 cord_uid: j1sg46w9 file: cache/cord-333688-bykbyojs.json key: cord-333688-bykbyojs authors: Wang, Junxue; Hang, Xiaofeng; Wei, Bo; Li, Dingchen; Chen, Fangyan; Liu, Wei; Yang, Chaojie; Miao, Xiaohui; Han, Li title: Persistent SARS-COV-2 RNA positivity in a patient for 92 days after disease onset: A case report date: 2020-08-21 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000021865 sha: doc_id: 333688 cord_uid: bykbyojs file: cache/cord-332992-8rmqg4rf.json key: cord-332992-8rmqg4rf authors: de Vries, A. A. F. title: SARS-CoV-2/COVID-19: a primer for cardiologists date: 2020-07-15 journal: Neth Heart J DOI: 10.1007/s12471-020-01475-1 sha: doc_id: 332992 cord_uid: 8rmqg4rf file: cache/cord-333175-klnxnxwm.json key: cord-333175-klnxnxwm authors: Hussein, Mohammad H.; Toraih, Eman A.; Attia, Abdallah S.; Burley, Nicholas; Zhang, Allen D.; Roos, Jackson; Houghton, August; Aniemeka, Nedum; Omar, Mahmoud; Aboueisha, Mohamed; Shama, Mohamed A.; Duchesne, Juan; Kandil, Emad title: Asthma in COVID-19 patients: An extra chain fitting around the neck? date: 2020-11-11 journal: Respir Med DOI: 10.1016/j.rmed.2020.106205 sha: doc_id: 333175 cord_uid: klnxnxwm file: cache/cord-333698-e73d9lbu.json key: cord-333698-e73d9lbu authors: Lechien, Jerome R.; Chiesa-Estomba, Carlos M.; Cabaraux, Pierre; Mat, Quentin; Huet, Kathy; Harmegnies, Bernard; Horoi, Mihaela; Bon, Serge D. Le; Rodriguez, Alexandra; Dequanter, Didier; Hans, Stéphane; Crevier-Buchman, Lise; Hochet, Baptiste; Distinguin, Lea; Chekkoury-Idrissi, Younes; Circiu, Marta; Afia, Fahd El; Barillari, Maria Rosaria; Cammaroto, Giovanni; Fakhry, Nicolas; Michel, Justin; Radulesco, Thomas; Martiny, Delphine; Lavigne, Philippe; Jouffe, Lionel; Descamps, Géraldine; Journe, Fabrice; Trecca, Eleonora M.C.; Hsieh, Julien; Delgado, Irene Lopez; Calvo-Henriquez, Christian; Vergez, Sebastien; Khalife, Mohamad; Molteni, Gabriele; Mannelli, Giuditta; Cantarella, Giovanna; Tucciarone, Manuel; Souchay, Christel; Leich, Pierre; Ayad, Tareck; Saussez, Sven title: Features of Mild-to-Moderate COVID-19 Patients with Dysphonia. date: 2020-06-04 journal: J Voice DOI: 10.1016/j.jvoice.2020.05.012 sha: doc_id: 333698 cord_uid: e73d9lbu file: cache/cord-334075-ruqd2c1j.json key: cord-334075-ruqd2c1j authors: Der Sarkissian, Samuel; Tjokrowidjaja, Angelica; Sebaratnam, Deshan F; Gupta, Monisha title: Response of a tertiary dermatology department to COVID‐19 date: 2020-04-21 journal: Australas J Dermatol DOI: 10.1111/ajd.13298 sha: doc_id: 334075 cord_uid: ruqd2c1j file: cache/cord-335168-3ofarutr.json key: cord-335168-3ofarutr authors: Bhat, Yasmeen Jabeen; Aslam, Aaqib; Hassan, Iffat; Dogra, Sunil title: Impact of COVID-19 Pandemic on Dermatologists and Dermatology Practice date: 2020-05-10 journal: Indian Dermatol Online J DOI: 10.4103/idoj.idoj_180_20 sha: doc_id: 335168 cord_uid: 3ofarutr file: cache/cord-335078-z7k59k8o.json key: cord-335078-z7k59k8o authors: Burton-Papp, Helmi C.; Jackson, Alexander I. R.; Beecham, Ryan; Ferrari, Matteo; Nasim-Mohi, Myra; Grocott, Michael P. W.; Chambers, Robert; Dushianthan, Ahilanandan title: Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre date: 2020-07-31 journal: F1000Res DOI: 10.12688/f1000research.25384.1 sha: doc_id: 335078 cord_uid: z7k59k8o file: cache/cord-333808-deifddar.json key: cord-333808-deifddar authors: McGregor, Bradley A; Vidal, Gregory A; Shah, Sumit A; Mitchell, James D; Hendifar, Andrew E title: Remote Oncology Care: Review of Current Technology and Future Directions date: 2020-08-31 journal: Cureus DOI: 10.7759/cureus.10156 sha: doc_id: 333808 cord_uid: deifddar file: cache/cord-335597-anrzcsrt.json key: cord-335597-anrzcsrt authors: nan title: 44. Jahrestagung der Österreichischen Gesellschaft für Pneumologie date: 2020-10-26 journal: Wien Klin Wochenschr DOI: 10.1007/s00508-020-01745-3 sha: doc_id: 335597 cord_uid: anrzcsrt file: cache/cord-333142-ek7hct52.json key: cord-333142-ek7hct52 authors: Patel, Shivani A.; Sharma, Hanspria; Mohan, Sailesh; Weber, Mary Beth; Jindal, Devraj; Jarhyan, Prashant; Gupta, Priti; Sharma, Rakshit; Ali, Mumtaj; Ali, Mohammed K.; Narayan, K. M. Venkat; Prabhakaran, Dorairaj; Gupta, Yashdeep; Roy, Ambuj; Tandon, Nikhil title: The Integrated Tracking, Referral, and Electronic Decision Support, and Care Coordination (I-TREC) program: scalable strategies for the management of hypertension and diabetes within the government healthcare system of India date: 2020-11-09 journal: BMC Health Serv Res DOI: 10.1186/s12913-020-05851-w sha: doc_id: 333142 cord_uid: ek7hct52 file: cache/cord-334212-3gqzeakb.json key: cord-334212-3gqzeakb authors: Chun, Tristen T.; Jimenez, Juan Carlos; Pantoja, Joe L.; Moriarty, John M.; Freeman, Shanna title: Phlegmasia Cerulea Dolens Associated with Acute COVID-19 Pneumonia Despite Supratherapeutic Warfarin Anticoagulation date: 2020-10-19 journal: J Vasc Surg Cases Innov Tech DOI: 10.1016/j.jvscit.2020.10.002 sha: doc_id: 334212 cord_uid: 3gqzeakb file: cache/cord-334881-x9nxxled.json key: cord-334881-x9nxxled authors: Di Lorenzo, Giuseppe; Di Trolio, Rossella; Kozlakidis, Zisis; Busto, Giuseppina; Ingenito, Concetta; Buonerba, Luciana; Ferrara, Claudia; Libroia, Annamaria; Ragone, Gianluca; Ioio, Concetta dello; Savastano, Beatrice; Polverino, Mario; De Falco, Ferdinando; Iaccarino, Simona; Leo, Emilio title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 journal: Crit Rev Oncol Hematol DOI: 10.1016/j.critrevonc.2020.102991 sha: doc_id: 334881 cord_uid: x9nxxled file: cache/cord-333528-9mczqtje.json key: cord-333528-9mczqtje authors: Mattogno, P. P.; Rigante, M.; Lauretti, L.; Parrilla, C.; D’Alessandris, Q. G.; Paludetti, G.; Olivi, A. title: Transnasal endoscopic skull base surgery during COVID-19 pandemic: algorithm of management in an Italian reference COVID center date: 2020-06-03 journal: Acta Neurochir (Wien) DOI: 10.1007/s00701-020-04414-6 sha: doc_id: 333528 cord_uid: 9mczqtje file: cache/cord-334235-ymsiihwd.json key: cord-334235-ymsiihwd authors: Gray, Belinda; Semsarian, Christopher; Fatkin, Diane; Ingles, Jodie; Atherton, John J.; Davis, Andrew M.; Sanders, Prashanthan; Pachter, Nicholas; Skinner, Jonathan R.; Stiles, Martin K. title: Patients with Genetic Heart Disease and COVID-19: A Cardiac Society of Australia and New Zealand (CSANZ) Consensus Statement date: 2020-04-30 journal: Heart Lung Circ DOI: 10.1016/j.hlc.2020.04.006 sha: doc_id: 334235 cord_uid: ymsiihwd file: cache/cord-334495-7y1la856.json key: cord-334495-7y1la856 authors: Agricola, Eustachio; Beneduce, Alessandro; Esposito, Antonio; Ingallina, Giacomo; Palumbo, Diego; Palmisano, Anna; Ancona, Francesco; Baldetti, Luca; Pagnesi, Matteo; Melisurgo, Giulio; Zangrillo, Alberto; De Cobelli, Francesco title: Heart and Lung Multimodality Imaging in COVID-19 date: 2020-06-24 journal: JACC Cardiovasc Imaging DOI: 10.1016/j.jcmg.2020.05.017 sha: doc_id: 334495 cord_uid: 7y1la856 file: cache/cord-335312-yp73z008.json key: cord-335312-yp73z008 authors: Bergsland, Emily K.; Halperin, Daniel M.; Dillon, Joseph S.; Dasari, N. Arvind; Kunz, Pamela L.; Soares, Heloisa P.; Pryma, Daniel; Bodei, Lisa; Hope, Thomas; Soulen, Michael C.; Mailman, Josh; Howe, James R. title: North American Neuroendocrine Tumor Society Guide for Neuroendocrine Tumor Patient Health Care Providers During COVID-19 date: 2020-05-19 journal: Pancreas DOI: 10.1097/mpa.0000000000001561 sha: doc_id: 335312 cord_uid: yp73z008 file: cache/cord-335351-8hdok02n.json key: cord-335351-8hdok02n authors: Hashmi, Muhammad Daniyal; Alnababteh, Muhtadi; Vedantam, Karthik; Alunikummannil, Jojo; Oweis, Emil S.; Shorr, Andrew F. title: Assessing the need for transfer to the intensive care unit for Coronavirus-19 disease: Epidemiology and risk factors date: 2020-10-27 journal: Respir Med DOI: 10.1016/j.rmed.2020.106203 sha: doc_id: 335351 cord_uid: 8hdok02n file: cache/cord-335759-io18c6z0.json key: cord-335759-io18c6z0 authors: Sprik, Petra; Keenan, Angela Janssen; Boselli, Danielle; Cheeseboro, Sherri; Meadors, Patrick; Grossoehme, Daniel title: Feasibility and acceptability of a telephone-based chaplaincy intervention in a large, outpatient oncology center date: 2020-07-04 journal: Support Care Cancer DOI: 10.1007/s00520-020-05598-4 sha: doc_id: 335759 cord_uid: io18c6z0 file: cache/cord-332650-05oz5zwz.json key: cord-332650-05oz5zwz authors: Fiorelli, Silvia; Massullo, Domenico; Ibrahim, Mohsen; Piccioni, Federico; Andreetti, Claudio; Vanni, Camilla; Rocco, Monica; Rendina, Erino Angelo; Menna, Cecilia title: Perspectives in surgical and anaesthetic management of lung cancer in the era of coronavirus disease 2019 (COVID-19) date: 2020-08-26 journal: Eur J Cardiothorac Surg DOI: 10.1093/ejcts/ezaa295 sha: doc_id: 332650 cord_uid: 05oz5zwz file: cache/cord-335033-cwhm7v0s.json key: cord-335033-cwhm7v0s authors: Vergano, Marco; Bertolini, Guido; Giannini, Alberto; Gristina, Giuseppe R.; Livigni, Sergio; Mistraletti, Giovanni; Riccioni, Luigi; Petrini, Flavia title: Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic date: 2020-04-22 journal: Crit Care DOI: 10.1186/s13054-020-02891-w sha: doc_id: 335033 cord_uid: cwhm7v0s file: cache/cord-334188-bggt1i2e.json key: cord-334188-bggt1i2e authors: Solari, Domenico; Bove, Ilaria; Esposito, Felice; Cappabianca, Paolo; Cavallo, Luigi M. title: The nose lid for the endoscopic endonasal procedures during COVID-19 era: technical note date: 2020-08-11 journal: Acta Neurochir (Wien) DOI: 10.1007/s00701-020-04518-z sha: doc_id: 334188 cord_uid: bggt1i2e file: cache/cord-333654-8rg99di5.json key: cord-333654-8rg99di5 authors: Pillai, Presaad; Joseph, Joyce Pauline; Fadzillah, Nurul Huda Mohamad; Mahmod, Masliza title: COVID-19 AND MAJOR ORGAN THROMBOEMBOLISM: MANIFESTATIONS IN NEUROVASCULAR AND CARDIOVASCULAR SYSTEMS. date: 2020-10-24 journal: J Stroke Cerebrovasc Dis DOI: 10.1016/j.jstrokecerebrovasdis.2020.105427 sha: doc_id: 333654 cord_uid: 8rg99di5 file: cache/cord-333876-fhxkpbq7.json key: cord-333876-fhxkpbq7 authors: Rucker, Janet C.; Zee, David S. title: Cerebellum—Editorial Regarding Consensus Paper Consensus on Virtual Management of Vestibular Disorders: Urgent Versus Expedited Care. Shaikh et al., doi.org/10.1007/s12311-020—01178-8: The Return of the House Call: Evaluating Acutely Ill Patients with Vertigo in the Era of Virtual Health Care date: 2020-09-02 journal: Cerebellum DOI: 10.1007/s12311-020-01184-w sha: doc_id: 333876 cord_uid: fhxkpbq7 file: cache/cord-334002-irbpehts.json key: cord-334002-irbpehts authors: Silva, Michelle A; Perez, Oscar F Rojas; Añez, Luis M; Paris, Manuel title: Telehealth treatment engagement with Latinx populations during the COVID-19 pandemic date: 2020-10-08 journal: Lancet Psychiatry DOI: 10.1016/s2215-0366(20)30419-3 sha: doc_id: 334002 cord_uid: irbpehts file: cache/cord-335576-b34nc3ay.json key: cord-335576-b34nc3ay authors: Tsai, Andrew; Diawara, Oumou; Nahass, Ronald G.; Brunetti, Luigi title: Impact of tocilizumab administration on mortality in severe COVID-19 date: 2020-11-05 journal: Sci Rep DOI: 10.1038/s41598-020-76187-y sha: doc_id: 335576 cord_uid: b34nc3ay file: cache/cord-335198-qp964238.json key: cord-335198-qp964238 authors: Kotsimbos, T.; Humbert, M. title: Pandemic Treatments on Trial: The bigger picture date: 2020-08-03 journal: Eur Respir J DOI: 10.1183/13993003.02281-2020 sha: doc_id: 335198 cord_uid: qp964238 file: cache/cord-335140-njg0ln33.json key: cord-335140-njg0ln33 authors: Freeman, Ciara L; Mikhael, Joseph title: Covid‐19 and Myeloma: what are the implications for now and in the future? date: 2020-05-19 journal: Br J Haematol DOI: 10.1111/bjh.16815 sha: doc_id: 335140 cord_uid: njg0ln33 file: cache/cord-335593-cjb0daps.json key: cord-335593-cjb0daps authors: Romagnolo, Alberto; Balestrino, Roberta; Imbalzano, Gabriele; Ciccone, Giovannino; Riccardini, Franco; Artusi, Carlo Alberto; Bozzali, Marco; Ferrero, Bruno; Montalenti, Elisa; Montanaro, Elisa; Rizzone, Mario Giorgio; Vaula, Giovanna; Zibetti, Maurizio; Lopiano, Leonardo title: Neurological comorbidity and severity of COVID-19 date: 2020-08-04 journal: J Neurol DOI: 10.1007/s00415-020-10123-y sha: doc_id: 335593 cord_uid: cjb0daps file: cache/cord-336194-5v395xae.json key: cord-336194-5v395xae authors: Darafsheh, Arash; Lavvafi, Hossein; Taleei, Reza; Khan, Rao title: Mitigating disruptions, and scalability of radiation oncology physics work during the COVID‐19 pandemic date: 2020-05-20 journal: J Appl Clin Med Phys DOI: 10.1002/acm2.12896 sha: doc_id: 336194 cord_uid: 5v395xae file: cache/cord-335338-wzxjn5ip.json key: cord-335338-wzxjn5ip authors: Wei, Lan; Sun, Shen; Xu, Cai-hong; Zhang, Jing; Xu, Yun; Zhu, Hong; Peh, Suat-cheng; Korteweg, Christine; McNutt, Michael A.; Gu, Jiang title: Pathology of the thyroid in severe acute respiratory syndrome() date: 2006-09-25 journal: Hum Pathol DOI: 10.1016/j.humpath.2006.06.011 sha: doc_id: 335338 cord_uid: wzxjn5ip file: cache/cord-336053-cjq7szcn.json key: cord-336053-cjq7szcn authors: Mottola, Filiberto Fausto; Verde, Nicoletta; Ricciolino, Riccardo; Di Mauro, Marco; Migliaccio, Marco Giuseppe; Carfora, Vincenzo; Spiniello, Giorgio; Coppola, Nicola title: Cardiovascular System in COVID-19: Simply a Viewer or a Leading Actor? date: 2020-08-27 journal: Life (Basel) DOI: 10.3390/life10090165 sha: doc_id: 336053 cord_uid: cjq7szcn file: cache/cord-335465-sckfkciz.json key: cord-335465-sckfkciz authors: Gupta, Rishi K.; Marks, Michael; Samuels, Thomas H. A.; Luintel, Akish; Rampling, Tommy; Chowdhury, Humayra; Quartagno, Matteo; Nair, Arjun; Lipman, Marc; Abubakar, Ibrahim; van Smeden, Maarten; Wong, Wai Keong; Williams, Bryan; Noursadeghi, Mahdad title: Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study date: 2020-09-25 journal: Eur Respir J DOI: 10.1183/13993003.03498-2020 sha: doc_id: 335465 cord_uid: sckfkciz file: cache/cord-335916-fh28qrt7.json key: cord-335916-fh28qrt7 authors: Liu, Cuiwei; Zhao, Yanxia; Okwan-Duodu, Derick; Basho, Reva; Cui, Xiaojiang title: COVID-19 in cancer patients: risk, clinical features, and management date: 2020-08-15 journal: Cancer Biol Med DOI: 10.20892/j.issn.2095-3941.2020.0289 sha: doc_id: 335916 cord_uid: fh28qrt7 file: cache/cord-333749-45v6b4tc.json key: cord-333749-45v6b4tc authors: Xie, Guogang; Ding, Fengming; Han, Lei; Yin, Dongning; Lu, Hongzhou; Zhang, Min title: The role of peripheral blood eosinophil counts in COVID‐19 patients date: 2020-06-20 journal: Allergy DOI: 10.1111/all.14465 sha: doc_id: 333749 cord_uid: 45v6b4tc file: cache/cord-335095-epsi5qq7.json key: cord-335095-epsi5qq7 authors: Feng, Gong; Huang, Wan-Qiang; Liu, Man-Ling; Lin, Si-Ceng; Zhang, Xiao-Zhou; Zhang, Yan; He, Xiao-Qing; Liu, Jun-Lin; Chen, Zi-Jun; Guo, Zi-Kai; Gao, Jie; Yao, Cheng-Zi; He, Na; Yan, Qin-Qin; Mi, Man title: Clinical Features of COVID-19 Patients in Xiaogan City date: 2020-08-24 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00465-z sha: doc_id: 335095 cord_uid: epsi5qq7 file: cache/cord-335680-wsczl68g.json key: cord-335680-wsczl68g authors: Brown, Charles A.; O'Connell, John B. title: Myocarditis and idiopathic dilated cardiomyopathy date: 1995-09-30 journal: The American Journal of Medicine DOI: 10.1016/s0002-9343(99)80164-8 sha: doc_id: 335680 cord_uid: wsczl68g file: cache/cord-334773-yw2qgv13.json key: cord-334773-yw2qgv13 authors: Lisco, Giuseppe; De Tullio, Anna; Giagulli, Vito Angelo; Guastamacchia, Edoardo; De Pergola, Giovanni; Triggiani, Vincenzo title: Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review date: 2020-08-10 journal: Endocrine DOI: 10.1007/s12020-020-02444-9 sha: doc_id: 334773 cord_uid: yw2qgv13 file: cache/cord-336306-hvy9ukhh.json key: cord-336306-hvy9ukhh authors: Zhu, Jieyun; Ji, Pan; Pang, Jielong; Zhong, Zhimei; Li, Hongyuan; He, Cuiying; Zhang, Jianfeng; Zhao, Chunling title: Clinical characteristics of 3,062 COVID‐19 patients: a meta‐analysis date: 2020-04-15 journal: J Med Virol DOI: 10.1002/jmv.25884 sha: doc_id: 336306 cord_uid: hvy9ukhh file: cache/cord-336252-e92omqyr.json key: cord-336252-e92omqyr authors: Chen, Tracy Yixin; Farghaly, Sara; Cham, Samantha; Tatem, Luis Lantigua; Sin, Jonathan H.; Rauda, Roberto; Ribisi, Maria; Sumrani, Nabil title: COVID‐19 pneumonia in kidney transplant recipients: Focus on immunosuppression management date: 2020-07-06 journal: Transpl Infect Dis DOI: 10.1111/tid.13378 sha: doc_id: 336252 cord_uid: e92omqyr file: cache/cord-336258-dxps48bo.json key: cord-336258-dxps48bo authors: Lee, Anne W.M.; Xu, Zhi-Yuan; Lin, Lily; Xu, Joy; Yang, Jin; Lee, Eric; Hui, Tim; Cheung, Jacob title: Advocacy to provide good quality oncology services during the COVID-19 pandemic – Actions at 3-Levels date: 2020-05-08 journal: Radiother Oncol DOI: 10.1016/j.radonc.2020.04.031 sha: doc_id: 336258 cord_uid: dxps48bo file: cache/cord-335719-tnimrff9.json key: cord-335719-tnimrff9 authors: Wang, Chia-shi; Ku, Elaine title: eHealth in kidney care date: 2020-04-01 journal: Nat Rev Nephrol DOI: 10.1038/s41581-020-0271-z sha: doc_id: 335719 cord_uid: tnimrff9 file: cache/cord-334835-j6u8t8j2.json key: cord-334835-j6u8t8j2 authors: Berenguer, Juan; Ryan, Pablo; Rodríguez-Baño, Jesús; Jarrín, Inmaculada; Carratalà, Jordi; Pachón, Jerónimo; Yllescas, María; Arribas, José Ramón title: Characteristics and predictors of death among 4,035 consecutively hospitalized patients with COVID-19 in Spain date: 2020-08-04 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2020.07.024 sha: doc_id: 334835 cord_uid: j6u8t8j2 file: cache/cord-335382-fk4um9nw.json key: cord-335382-fk4um9nw authors: Farver, Carol F.; Zander, Dani S. title: Molecular Basis of Pulmonary Disease date: 2012-08-10 journal: Molecular Pathology DOI: 10.1016/b978-0-12-374419-7.00018-4 sha: doc_id: 335382 cord_uid: fk4um9nw file: cache/cord-335795-hdko0zdw.json key: cord-335795-hdko0zdw authors: Wamsley, Christine E; Kramer, Alan; Kenkel, Jeffrey M; Amirlak, Bardia title: Trends and Challenges of Telehealth in an Academic Institution: The Unforeseen Benefits of the COVID-19 Global Pandemic date: 2020-07-22 journal: Aesthet Surg J DOI: 10.1093/asj/sjaa212 sha: doc_id: 335795 cord_uid: hdko0zdw file: cache/cord-335540-lahu5dno.json key: cord-335540-lahu5dno authors: Granata, Tiziana; Bisulli, Francesca; Arzimanoglou, Alexis; Rocamora, Rodrigo title: Did the COVID‐19 pandemic silence the needs of people with epilepsy? date: 2020-09-19 journal: Epileptic Disord DOI: 10.1684/epd.2020.1175 sha: doc_id: 335540 cord_uid: lahu5dno file: cache/cord-335265-kuc3v5m9.json key: cord-335265-kuc3v5m9 authors: Elghazawy, Hagar; Bakkach, Joaira; Zaghloul, Mohamed S; Abusanad, Atlal; Hussein, Mariam Mohamed; Alorabi, Mohamed; eldin, Nermean Bahie; Helal, Thanaa; Zaghloul, Tarek M; Venkatesulu, Bhanu Prasad; Elghazaly, Hesham; Al-Sukhun, Sana title: Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic date: 2020-07-27 journal: Future oncology DOI: 10.2217/fon-2020-0574 sha: doc_id: 335265 cord_uid: kuc3v5m9 file: cache/cord-335141-ag3j8obh.json key: cord-335141-ag3j8obh authors: Higgins, G.C.; Robertson, E.; Horsely, C.; McLean, N.; Douglas, J. title: FFP3 reusable respirators for COVID-19; adequate and suitable in the healthcare setting date: 2020-06-30 journal: J Plast Reconstr Aesthet Surg DOI: 10.1016/j.bjps.2020.06.002 sha: doc_id: 335141 cord_uid: ag3j8obh file: cache/cord-336268-azgswke8.json key: cord-336268-azgswke8 authors: Porcel-Vazquez, Juan A.; Andres-Peiro, Jose V.; Garcia-Sanchez, Yaiza; Guerra-Farfan, Ernesto; Mestre-Torres, Jaume; Minguell-Monyart, Joan; Molero-Garcia, Vicente; Selga Marsa, Jordi; Tomas-Hernandez, Jordi; Villar-Casares, Maria del Mar; Bhandari, Mohit; Teixidor-Serra, Jordi title: Usefulness of PCR Screening in the Initial Triage of Trauma Patients During COVID-19 Pandemic date: 2020-07-13 journal: J Orthop Trauma DOI: 10.1097/bot.0000000000001903 sha: doc_id: 336268 cord_uid: azgswke8 file: cache/cord-335892-hwahcec5.json key: cord-335892-hwahcec5 authors: Marshall, Elena; Robertson, Matt; Kam, Satu; Penwarden, Alison; Riga, Paraskevi; Davies, Nigel title: Prevalence of hydroxychloroquine retinopathy using 2018 Royal College of Ophthalmologists diagnostic criteria date: 2020-06-25 journal: Eye (Lond) DOI: 10.1038/s41433-020-1038-2 sha: doc_id: 335892 cord_uid: hwahcec5 file: cache/cord-335744-haj5a7tf.json key: cord-335744-haj5a7tf authors: Chibbaro, Salvatore title: How SARS-CoV-2 is forcing us to reconsider and reorganize our daily neurosurgical practice date: 2020-05-13 journal: Neurochirurgie DOI: 10.1016/j.neuchi.2020.05.001 sha: doc_id: 335744 cord_uid: haj5a7tf file: cache/cord-335918-uc225mhn.json key: cord-335918-uc225mhn authors: nan title: COVID-19 Guidance for Triage of Operations for Thoracic Malignancies: A Consensus Statement from Thoracic Surgery Outcomes Research Network date: 2020-04-09 journal: J Thorac Cardiovasc Surg DOI: 10.1016/j.jtcvs.2020.03.061 sha: doc_id: 335918 cord_uid: uc225mhn file: cache/cord-335975-m6lkrehi.json key: cord-335975-m6lkrehi authors: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 journal: Ann Intensive Care DOI: 10.1186/s13613-017-0345-7 sha: doc_id: 335975 cord_uid: m6lkrehi file: cache/cord-336368-sudi4mdx.json key: cord-336368-sudi4mdx authors: Thiruvenkatarajan, Venkatesan; Dharmalingam, Ashok; Arenas, Gilberto; Wahba, Medhat; Steiner, Reinhard; Kadam, Vasanth Rao; Tran, Andre; Currie, John; Van Wijk, Roelof; Quail, Anthony; Ludbrook, Guy title: High-flow nasal cannula versus standard oxygen therapy assisting sedation during endoscopic retrograde cholangiopancreatography in high risk cases (OTHER): study protocol of a randomised multicentric trial date: 2020-05-29 journal: Trials DOI: 10.1186/s13063-020-04378-z sha: doc_id: 336368 cord_uid: sudi4mdx file: cache/cord-336201-fl606l3b.json key: cord-336201-fl606l3b authors: Daryabor, Gholamreza; Atashzar, Mohamad Reza; Kabelitz, Dieter; Meri, Seppo; Kalantar, Kurosh title: The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System date: 2020-07-22 journal: Front Immunol DOI: 10.3389/fimmu.2020.01582 sha: doc_id: 336201 cord_uid: fl606l3b file: cache/cord-336336-f01khqqr.json key: cord-336336-f01khqqr authors: Singh, Rajat; Domenico, Christopher; Rao, Sriram D.; Urgo, Kimberly; Prenner, Stuart B.; Wald, Joyce W.; Atluri, Pavan; Birati, Edo Y. title: Therapeutic Strategy for Coronavirus Disease 2019 in Patients on Durable Left Ventricular Assist Device Support date: 2020-05-13 journal: J Card Fail DOI: 10.1016/j.cardfail.2020.05.001 sha: doc_id: 336336 cord_uid: f01khqqr file: cache/cord-336000-v88bq4bx.json key: cord-336000-v88bq4bx authors: Barco, Stefano; Bingisser, Roland; Colucci, Giuseppe; Frenk, André; Gerber, Bernhard; Held, Ulrike; Mach, Francois; Mazzolai, Lucia; Righini, Marc; Rosemann, Thomas; Sebastian, Tim; Spescha, Rebecca; Stortecky, Stefan; Windecker, Stephan; Kucher, Nils title: Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date: 2020-09-09 journal: Trials DOI: 10.1186/s13063-020-04678-4 sha: doc_id: 336000 cord_uid: v88bq4bx file: cache/cord-336314-xf6zvvl8.json key: cord-336314-xf6zvvl8 authors: Hu, Lijuan; Gong, Linjing; Jiang, Zhilong; Wang, Qibing; Zou, Yunzeng; Zhu, Lei title: Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia date: 2020-05-26 journal: Crit Care DOI: 10.1186/s13054-020-02933-3 sha: doc_id: 336314 cord_uid: xf6zvvl8 file: cache/cord-336395-v157jzvv.json key: cord-336395-v157jzvv authors: Battaglini, Denise; Robba, Chiara; Caiffa, Salvatore; Ball, Lorenzo; Brunetti, Iole; Loconte, Maurizio; Giacobbe, Daniele Roberto; Vena, Antonio; Patroniti, Nicolò; Bassetti, Matteo; Torres, Antoni; Rocco, Patricia RM; Pelosi, Paolo title: Chest physiotherapy: an important adjuvant in critically ill mechanically ventilated patients with COVID-19 date: 2020-08-17 journal: Respir Physiol Neurobiol DOI: 10.1016/j.resp.2020.103529 sha: doc_id: 336395 cord_uid: v157jzvv file: cache/cord-336390-ptnpgh3j.json key: cord-336390-ptnpgh3j authors: Passamonti, Francesco; Cattaneo, Chiara; Arcaini, Luca; Bruna, Riccardo; Cavo, Michele; Merli, Francesco; Angelucci, Emanuele; Krampera, Mauro; Cairoli, Roberto; Della Porta, Matteo Giovanni; Fracchiolla, Nicola; Ladetto, Marco; Gambacorti Passerini, Carlo; Salvini, Marco; Marchetti, Monia; Lemoli, Roberto; Molteni, Alfredo; Busca, Alessandro; Cuneo, Antonio; Romano, Alessandra; Giuliani, Nicola; Galimberti, Sara; Corso, Alessandro; Morotti, Alessandro; Falini, Brunangelo; Billio, Atto; Gherlinzoni, Filippo; Visani, Giuseppe; Tisi, Maria Chiara; Tafuri, Agostino; Tosi, Patrizia; Lanza, Francesco; Massaia, Massimo; Turrini, Mauro; Ferrara, Felicetto; Gurrieri, Carmela; Vallisa, Daniele; Martelli, Maurizio; Derenzini, Enrico; Guarini, Attilio; Conconi, Annarita; Cuccaro, Annarosa; Cudillo, Laura; Russo, Domenico; Ciambelli, Fabrizio; Scattolin, Anna Maria; Luppi, Mario; Selleri, Carmine; Ortu La Barbera, Elettra; Ferrandina, Celestino; Di Renzo, Nicola; Olivieri, Attilio; Bocchia, Monica; Gentile, Massimo; Marchesi, Francesco; Musto, Pellegrino; Federici, Augusto Bramante; Candoni, Anna; Venditti, Adriano; Fava, Carmen; Pinto, Antonio; Galieni, Piero; Rigacci, Luigi; Armiento, Daniele; Pane, Fabrizio; Oberti, Margherita; Zappasodi, Patrizia; Visco, Carlo; Franchi, Matteo; Grossi, Paolo Antonio; Bertù, Lorenza; Corrao, Giovanni; Pagano, Livio; Corradini, Paolo title: Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study date: 2020-08-13 journal: The Lancet Haematology DOI: 10.1016/s2352-3026(20)30251-9 sha: doc_id: 336390 cord_uid: ptnpgh3j file: cache/cord-335977-f00758o2.json key: cord-335977-f00758o2 authors: Martin-Loeches, I.; Lisboa, T.; Rhodes, A.; Moreno, R. P.; Silva, E.; Sprung, C.; Chiche, J. D.; Barahona, D.; Villabon, M.; Balasini, C.; Pearse, R. M.; Matos, R.; Rello, J. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 journal: Intensive Care Med DOI: 10.1007/s00134-010-2078-z sha: doc_id: 335977 cord_uid: f00758o2 file: cache/cord-336423-rs4bma9b.json key: cord-336423-rs4bma9b authors: Endersby, Ryan Vincent William; Ho, Esther Ching Yee; Spencer, Adam Oscar; Goldstein, David Howard; Schubert, Edward title: Barrier Devices for Reducing Aerosol and Droplet Transmission in Coronavirus Disease 2019 Patients: Advantages, Disadvantages, and Alternative Solutions date: 2020-05-12 journal: Anesth Analg DOI: 10.1213/ane.0000000000004953 sha: doc_id: 336423 cord_uid: rs4bma9b file: cache/cord-336790-29im4gxw.json key: cord-336790-29im4gxw authors: Violetis, Odyssefs A.; Chasouraki, Angeliki M.; Giannou, Alexandra M.; Baraboutis, Ioannis G. title: COVID-19 Infection and Haematological Involvement: a Review of Epidemiology, Pathophysiology and Prognosis of Full Blood Count Findings date: 2020-06-29 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00380-3 sha: doc_id: 336790 cord_uid: 29im4gxw file: cache/cord-336438-mlgxiyur.json key: cord-336438-mlgxiyur authors: Huda, Farhanul; Kumar, Praveen; Singh, Sudhir K.; Agarwal, Saumya; Basu, Somprakas title: Covid-19 and surgery: Challenging issues in the face of new normal – A narrative review date: 2020-10-23 journal: Ann Med Surg (Lond) DOI: 10.1016/j.amsu.2020.10.039 sha: doc_id: 336438 cord_uid: mlgxiyur file: cache/cord-337088-xxyhmn1t.json key: cord-337088-xxyhmn1t authors: Malhotra, Naveen; Joshi, Muralidhar; Datta, Rashmi; Bajwa, Sukhminder Jit Singh; Mehdiratta, Lalit title: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement regarding COVID-19 date: 2020-03-28 journal: Indian J Anaesth DOI: 10.4103/ija.ija_288_20 sha: doc_id: 337088 cord_uid: xxyhmn1t file: cache/cord-336554-n8n5ii5k.json key: cord-336554-n8n5ii5k authors: Singh, Thakur Uttam; Parida, Subhashree; Lingaraju, Madhu Cholenahalli; Kesavan, Manickam; Kumar, Dinesh; Singh, Raj Kumar title: Drug repurposing approach to fight COVID-19 date: 2020-09-05 journal: Pharmacol Rep DOI: 10.1007/s43440-020-00155-6 sha: doc_id: 336554 cord_uid: n8n5ii5k file: cache/cord-336450-2ndan331.json key: cord-336450-2ndan331 authors: Shaw, Katharina S.; Karagounis, Theodora K.; Yin, Lu; Gibbon, Grace; Betensky, Rebecca A.; Lo Sicco, Kristen I.; Femia, Alisa N. title: Response to “Patient preference for cellulitis treatment: at-home care is preferred to hospital-based treatment” date: 2020-08-07 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.07.120 sha: doc_id: 336450 cord_uid: 2ndan331 file: cache/cord-336462-7dltsav4.json key: cord-336462-7dltsav4 authors: Trovik, Linn Hereide; Sandnes, Miriam; Blomberg, Bjørn; Holmaas, Gunhild; Ahmed, Aymen Bushra; Tvedt, Tor Henrik Anderson; Vintermyr, Olav; Reikvam, Håkon title: Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report date: 2020-11-11 journal: J Med Case Rep DOI: 10.1186/s13256-020-02555-x sha: doc_id: 336462 cord_uid: 7dltsav4 file: cache/cord-336621-0w3rroir.json key: cord-336621-0w3rroir authors: Kim, Kyoung Ok title: A first step toward understanding patient safety date: 2016-07-25 journal: Korean J Anesthesiol DOI: 10.4097/kjae.2016.69.5.429 sha: doc_id: 336621 cord_uid: 0w3rroir file: cache/cord-337094-aa3ourc6.json key: cord-337094-aa3ourc6 authors: Ramella, Vittorio; Papa, Giovanni; Bottosso, Stefano; Cazzato, Vito; Arnež, Zoran Marij title: Microsurgical reconstruction in the time of COVID‐19 date: 2020-05-15 journal: Microsurgery DOI: 10.1002/micr.30604 sha: doc_id: 337094 cord_uid: aa3ourc6 file: cache/cord-336614-u6alc6rs.json key: cord-336614-u6alc6rs authors: Pérez-Belmonte, Luis M.; López-Carmona, María D.; Quevedo-Marín, Juan L.; Ricci, Michele; Martín-Carmona, Jesica; Sanz-Cánovas, Jaime; López-Sampalo, Almudena; Martín-Escalante, María D.; Bernal-López, M. Rosa.; Gómez-Huelgas, Ricardo title: Differences between Clinical Protocols for the Treatment of Coronavirus Disease 2019 (COVID-19) in Andalusia, Spain date: 2020-09-19 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17186845 sha: doc_id: 336614 cord_uid: u6alc6rs file: cache/cord-337487-1lbopaso.json key: cord-337487-1lbopaso authors: Hansildaar, Romy; Vedder, Daisy; Baniaamam, Milad; Tausche, Anne-Kathrin; Gerritsen, Martijn; Nurmohamed, Michael T title: Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout date: 2020-09-01 journal: Lancet Rheumatol DOI: 10.1016/s2665-9913(20)30221-6 sha: doc_id: 337487 cord_uid: 1lbopaso file: cache/cord-337115-vtjsigod.json key: cord-337115-vtjsigod authors: Liao, Xuelian; Wang, Bo; Kang, Yan title: Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province, China date: 2020-02-05 journal: Intensive Care Med DOI: 10.1007/s00134-020-05954-2 sha: doc_id: 337115 cord_uid: vtjsigod file: cache/cord-337297-fkw8780t.json key: cord-337297-fkw8780t authors: Fan, Siyuan; Xiao, Meng; Han, Fei; Xia, Peng; Bai, Xiaoyin; Chen, Huan; Zhang, Hongmin; Ding, Xin; Zhao, Hua; Zhao, Jing; Sun, Xuefeng; Jiang, Wei; Wang, Chunyao; Cao, Wei; Guo, Fan; Tian, Ran; Gao, Peng; Wu, Wei; Ma, Jie; Wu, Dong; Liu, Zhengyin; Zhou, Xiang; Wang, Jinglan; Guan, Tianjia; Qin, Yan; Li, Taisheng; Xu, Yingchun; Zhang, Dong; Chen, Yu; Xie, Jing; Li, Yongzhe; Yan, Xiaowei; Zhu, Yicheng; Peng, Bin; Cui, Liying; Zhang, Shuyang; Guan, Hongzhi title: Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study date: 2020-07-10 journal: Front Neurol DOI: 10.3389/fneur.2020.00806 sha: doc_id: 337297 cord_uid: fkw8780t file: cache/cord-337120-irpm5g7g.json key: cord-337120-irpm5g7g authors: Lee, Bruce Y. title: The Role of Internists During Epidemics, Outbreaks, and Bioterrorist Attacks date: 2007-01-13 journal: J Gen Intern Med DOI: 10.1007/s11606-006-0030-2 sha: doc_id: 337120 cord_uid: irpm5g7g file: cache/cord-337010-dgy7qbl5.json key: cord-337010-dgy7qbl5 authors: Tomazini, B. M.; Maia, I. S.; Bueno, F. R.; Silva, M. V. A. O.; Baldassare, F. P.; Costa, E. L. V.; Moura, R. A. B.; Honorato, M.; Costa, A. N.; Cavalcanti, A. B.; Rosa, R.; Avezum, A.; Veiga, V. C.; Lopes, R. D.; Damiani, L. P.; Machado, F. R.; Berwanger, O.; Azevedo, L. C. P. title: COVID-19-associated ARDS treated with DEXamethasone (CoDEX): Study design and rationale for a randomized trial. date: 2020-06-26 journal: nan DOI: 10.1101/2020.06.24.20139303 sha: doc_id: 337010 cord_uid: dgy7qbl5 file: cache/cord-337262-88qpfu6b.json key: cord-337262-88qpfu6b authors: File, Thomas M. title: 26 Community-Acquired Pneumonia, Bacterial date: 2012-12-31 journal: Netter’s Infectious Diseases DOI: 10.1016/b978-1-4377-0126-5.00026-4 sha: doc_id: 337262 cord_uid: 88qpfu6b file: cache/cord-337338-7uj2r0gy.json key: cord-337338-7uj2r0gy authors: Ohlstein, Jason F.; Garner, Jordan; Takashima, Masayoshi title: Telemedicine in Otolaryngology in the COVID‐19 Era: Initial Lessons Learned date: 2020-08-02 journal: Laryngoscope DOI: 10.1002/lary.29030 sha: doc_id: 337338 cord_uid: 7uj2r0gy file: cache/cord-336782-0zkb39v1.json key: cord-336782-0zkb39v1 authors: Fraile Gutiérrez, V.; Ayuela Azcárate, J. M.; Pérez Torres, D.; Zapata, L.; Rodríguez Yakushev, A. L.; Ochagavía Calvo, A. title: Narrative review of ultrasound in the management of the critically ill patient with SARS-CoV-2 infection (COVID-19): clinical applications in intensive care medicine date: 2020-11-02 journal: nan DOI: 10.1016/j.medine.2020.10.002 sha: doc_id: 336782 cord_uid: 0zkb39v1 file: cache/cord-336882-x9e6r0h0.json key: cord-336882-x9e6r0h0 authors: Sambare, Tanmaya; Bozic, Kevin J. title: Preparing for an Era of Episode-Based Care in Total Joint Arthroplasty date: 2020-09-22 journal: J Arthroplasty DOI: 10.1016/j.arth.2020.09.028 sha: doc_id: 336882 cord_uid: x9e6r0h0 file: cache/cord-337302-fpz2jfuj.json key: cord-337302-fpz2jfuj authors: Abdihamid, Omar; Cai, Changjing; Kapesa, Linda; Zeng, Shan title: The Landscape of COVID-19 in Cancer Patients: Prevalence, Impacts, and Recommendations date: 2020-09-23 journal: Cancer Manag Res DOI: 10.2147/cmar.s272008 sha: doc_id: 337302 cord_uid: fpz2jfuj file: cache/cord-337896-mct29erg.json key: cord-337896-mct29erg authors: Kornbluth, Asher; Kissous-Hunt, Michele; George, James; Legnani, Peter title: Management of Inflammatory Bowel Disease and COVID-19 in New York City 2020: The Epicenter of IBD in the First Epicenter of the Global Pandemic date: 2020-09-03 journal: Inflamm Bowel Dis DOI: 10.1093/ibd/izaa212 sha: doc_id: 337896 cord_uid: mct29erg file: cache/cord-337898-ncrbd8rp.json key: cord-337898-ncrbd8rp authors: Pal, Rimesh; Banerjee, Mainak title: Comment on “Is the type of diabetes treatment relevant to outcome of COVID‐19?” date: 2020-05-27 journal: J Diabetes DOI: 10.1111/1753-0407.13069 sha: doc_id: 337898 cord_uid: ncrbd8rp file: cache/cord-336563-hwemigk7.json key: cord-336563-hwemigk7 authors: Bhimraj, Adarsh; Morgan, Rebecca L; Shumaker, Amy Hirsch; Lavergne, Valery; Baden, Lindsey; Cheng, Vincent Chi-Chung; Edwards, Kathryn M; Gandhi, Rajesh; Muller, William J; O’Horo, John C; Shoham, Shmuel; Murad, M Hassan; Mustafa, Reem A; Sultan, Shahnaz; Falck-Ytter, Yngve title: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 date: 2020-04-27 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa478 sha: doc_id: 336563 cord_uid: hwemigk7 file: cache/cord-336488-opjjowcq.json key: cord-336488-opjjowcq authors: Kenanidis, Eustathios; Anagnostis, Panagiotis; Arvaniti, Kostoula; Potoupnis, Michael E; Tsiridis, Eleftherios title: Organizing an Orthopaedic Department During COVID-19 Pandemic to Mitigate In-Hospital Transmission: Experience From Greece date: 2020-06-17 journal: Cureus DOI: 10.7759/cureus.8676 sha: doc_id: 336488 cord_uid: opjjowcq file: cache/cord-337520-qp0ga6q8.json key: cord-337520-qp0ga6q8 authors: Binning, Mandy; Strenger, Scott; Greenberg, Karen title: Cardiopulmonary resuscitation causing thoracolumbar hyperextension with severe spinal cord injury: A case report date: 2020-09-03 journal: Radiol Case Rep DOI: 10.1016/j.radcr.2020.08.017 sha: doc_id: 337520 cord_uid: qp0ga6q8 file: cache/cord-337906-qis8h3r3.json key: cord-337906-qis8h3r3 authors: Suresh Kumar, Vishnu Charan; Harne, Prateek Suresh; Mukherjee, Samiran; Gupta, Kashvi; Masood, Umair; Sharma, Anuj Vikrant; Lamichhane, Jivan; Dhamoon, Amit Singh; Sapkota, Bishnu title: Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study date: 2020-09-27 journal: World J Hepatol DOI: 10.4254/wjh.v12.i9.619 sha: doc_id: 337906 cord_uid: qis8h3r3 file: cache/cord-337995-z4rcczki.json key: cord-337995-z4rcczki authors: Moris, Dimitrios; Kesseli, Samuel J.; Barbas, Andrew S. title: Kidney Transplant Recipients Infected By COVID‐19: Review of the Initial Published Experience date: 2020-07-23 journal: Transpl Infect Dis DOI: 10.1111/tid.13426 sha: doc_id: 337995 cord_uid: z4rcczki file: cache/cord-337644-aobdzwpx.json key: cord-337644-aobdzwpx authors: Pianta, L.; Vinciguerra, A.; Bertazzoni, G.; Morello, R.; Mangiatordi, F.; Lund, V. J.; Trimarchi, M. title: Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19 date: 2020-05-24 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06067-8 sha: doc_id: 337644 cord_uid: aobdzwpx file: cache/cord-337665-roelk7i5.json key: cord-337665-roelk7i5 authors: Bhattacharjee, Hemanga K.; Chaliyadan, Shafneed; Verma, Eshan; Kumaran, Keerthi; Bhargava, Priyank; Singh, Abhishek; Maitra, Souvik; Parshad, Rajinder title: Emergency Surgery during COVID-19: Lessons Learned date: 2020-09-30 journal: Surg J (N Y) DOI: 10.1055/s-0040-1716335 sha: doc_id: 337665 cord_uid: roelk7i5 file: cache/cord-336784-24qizp9k.json key: cord-336784-24qizp9k authors: Robinson, Victoria A; MacDonald, Russell D; Manuel, Doug; Goel, Vivek title: Validation of the Provincial Transfer Authorization Centre database: a comprehensive database containing records of all inter-facility patient transfers in the province of Ontario date: 2006-10-06 journal: BMC Health Serv Res DOI: 10.1186/1472-6963-6-129 sha: doc_id: 336784 cord_uid: 24qizp9k file: cache/cord-336810-77wq9laa.json key: cord-336810-77wq9laa authors: Klocperk, Adam; Bloomfield, Marketa; Parackova, Zuzana; Zentsova, Irena; Vrabcova, Petra; Balko, Jan; Meseznikov, Grigorij; Casas Mendez, Luis Fernando; Grandcourtova, Alzbeta; Sipek, Jan; Tulach, Martin; Zamecnik, Josef; Vymazal, Tomas; Sediva, Anna title: Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19 date: 2020-09-17 journal: J Clin Med DOI: 10.3390/jcm9093000 sha: doc_id: 336810 cord_uid: 77wq9laa file: cache/cord-338146-am5gg1qd.json key: cord-338146-am5gg1qd authors: Bindi, E.; Cruccetti, A.; Ilari, M.; Mariscoli, F.; Carnielli, V.P.; Simonini, A.; Cobellis, G. title: Meckel's diverticulum perforation in a newborn positive to Sars-Cov-2 date: 2020-08-29 journal: J Pediatr Surg Case Rep DOI: 10.1016/j.epsc.2020.101641 sha: doc_id: 338146 cord_uid: am5gg1qd file: cache/cord-338968-b1gg2ha7.json key: cord-338968-b1gg2ha7 authors: La Rosée, Felicitas; La Rosée, Paul title: Ruxolitinib in COVID-19 Hyperinflammation and Haematologic Malignancies date: 2020-08-20 journal: Acta Haematol DOI: 10.1159/000510770 sha: doc_id: 338968 cord_uid: b1gg2ha7 file: cache/cord-336543-ydrmlujj.json key: cord-336543-ydrmlujj authors: Cavalli, Eugenio; Bramanti, Alessia; Ciurleo, Rosella; Tchorbanov, Andrey I.; Giordano, Antonio; Fagone, Paolo; Belizna, Cristina; Bramanti, Placido; Shoenfeld, Yehuda; Nicoletti, Ferdinando title: Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review) date: 2020-06-25 journal: Int J Mol Med DOI: 10.3892/ijmm.2020.4659 sha: doc_id: 336543 cord_uid: ydrmlujj file: cache/cord-338192-2v9dbc9h.json key: cord-338192-2v9dbc9h authors: Dai, J. D.; Gluzman, M.; Janmohamed, A.; Xu, Y. title: How many patients will need ventilators tomorrow? date: 2020-05-21 journal: nan DOI: 10.1101/2020.05.18.20105783 sha: doc_id: 338192 cord_uid: 2v9dbc9h file: cache/cord-338517-1mxcssjj.json key: cord-338517-1mxcssjj authors: Ishay, Yuval; Kessler, Asa; Schwarts, Asaf; Ilan, Yaron title: Antibody response to SARS‐Co‐V‐2, diagnostic and therapeutic implications date: 2020-08-26 journal: Hepatol Commun DOI: 10.1002/hep4.1600 sha: doc_id: 338517 cord_uid: 1mxcssjj file: cache/cord-337622-rc9pejmo.json key: cord-337622-rc9pejmo authors: Sansom‐Daly, Ursula M.; Bradford, Natalie title: Grappling with the ‘human’ problem hiding behind the technology: Telehealth during and beyond COVID‐19 date: 2020-07-06 journal: Psychooncology DOI: 10.1002/pon.5462 sha: doc_id: 337622 cord_uid: rc9pejmo file: cache/cord-339015-qn8wbnlw.json key: cord-339015-qn8wbnlw authors: Kayingo, Gerald title: Bacteria and Viruses: The Bogeymen in the Intensive Care Unit date: 2019-03-06 journal: Physician Assist Clin DOI: 10.1016/j.cpha.2018.11.003 sha: doc_id: 339015 cord_uid: qn8wbnlw file: cache/cord-339021-mhdaov1f.json key: cord-339021-mhdaov1f authors: Hong, Kyung Soo; Lee, Kwan Ho; Chung, Jin Hong; Shin, Kyeong-Cheol; Choi, Eun Young; Jin, Hyun Jung; Jang, Jong Geol; Lee, Wonhwa; Ahn, June Hong title: Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study date: 2020-05-01 journal: Yonsei Med J DOI: 10.3349/ymj.2020.61.5.431 sha: doc_id: 339021 cord_uid: mhdaov1f file: cache/cord-338666-gg9qcpmz.json key: cord-338666-gg9qcpmz authors: Rubin, Geoffrey A.; Wan, Elaine Y.; Saluja, Deepak; Thomas, George; Slotwiner, David J.; Goldbarg, Seth; Chaudhary, Salma; Turitto, Gioia; Dizon, Jose; Yarmohammadi, Hirad; Ehlert, Frederick; Rubin, David A.; Morrow, John P.; Waase, Marc; Berman, Jeremy; Kushnir, Alexander; Abrams, Mark P.; Halik, Carolyn; Kumaraiah, Deepa; Schwartz, Allan; Kirtane, Ajay; Kodali, Susheel; Goldenthal, Isaac; Garan, Hasan; Biviano, Angelo title: Restructuring Electrophysiology During the COVID-19 Pandemic: A Practical Guide From a New York City Hospital Network date: 2020-04-27 journal: Crit Pathw Cardiol DOI: 10.1097/hpc.0000000000000225 sha: doc_id: 338666 cord_uid: gg9qcpmz file: cache/cord-337431-3rrvm787.json key: cord-337431-3rrvm787 authors: Dimopoulos, G; Tsiodras, S; Lerikou, M; Chranioti, Aik; Perros, E; Anagnostopoulou, U; Karakitsos, P; Armaganidis, A title: Viral Profile of COPD Exacerbations According to Patients§ date: 2015-02-23 journal: Open Respir Med J DOI: 10.2174/1874306401509010001 sha: doc_id: 337431 cord_uid: 3rrvm787 file: cache/cord-337926-6ddvqowr.json key: cord-337926-6ddvqowr authors: Farrell, Sarah; Schaeffer, Emily K.; Mulpuri, Kishore title: Recommendations for the Care of Pediatric Orthopaedic Patients During the COVID Pandemic date: 2020-04-14 journal: J Am Acad Orthop Surg DOI: 10.5435/jaaos-d-20-00391 sha: doc_id: 337926 cord_uid: 6ddvqowr file: cache/cord-337994-pkklt77i.json key: cord-337994-pkklt77i authors: Brouqui, P.; Giraud-Gatineau, A.; Raoult, D. title: Remdesivir investigational trials in COVID-19: a critical reappraisal date: 2020-06-07 journal: New Microbes New Infect DOI: 10.1016/j.nmni.2020.100707 sha: doc_id: 337994 cord_uid: pkklt77i file: cache/cord-338135-zwo7e7gy.json key: cord-338135-zwo7e7gy authors: Melis, Daniele; Mugheddu, Cristina; Sanna, Silvia; Atzori, Laura; Rongioletti, Franco title: Clinical efficacy, speed of improvement and safety of apremilast for the treatment of adult Psoriasis during COVID‐19 pandemic date: 2020-05-30 journal: Dermatol Ther DOI: 10.1111/dth.13722 sha: doc_id: 338135 cord_uid: zwo7e7gy file: cache/cord-338362-6zwvkqag.json key: cord-338362-6zwvkqag authors: Cohen, Donald F.; Kurkowski, Michael A.; Wilson, Robert J.; Jonke, Guenter J.; Patel, Onika R.; Pappas, Renee P.; Hall, Daniel W.; Pandya, Anisha title: Ethical practice during the COVID-19 pandemic date: 2020-04-08 journal: J Am Dent Assoc DOI: 10.1016/j.adaj.2020.03.038 sha: doc_id: 338362 cord_uid: 6zwvkqag file: cache/cord-338900-8ojah695.json key: cord-338900-8ojah695 authors: MacDonald, David S. MacDonald; Colosi, Dan C.; Mupparapu, Muralidhar; Kumar, Verdana; Shintaku, Werner H.; Mansur, Ahmad title: Guidelines for Oral and Maxillofacial Imaging: COVID-19 Considerations date: 2020-10-26 journal: Oral Surg Oral Med Oral Pathol Oral Radiol DOI: 10.1016/j.oooo.2020.10.017 sha: doc_id: 338900 cord_uid: 8ojah695 file: cache/cord-338668-z2z4gte2.json key: cord-338668-z2z4gte2 authors: Veraldi, Stefano; Angileri, Luisa; Barbareschi, Mauro title: Seborrheic dermatitis and masks date: 2020-08-13 journal: J Cosmet Dermatol DOI: 10.1111/jocd.13669 sha: doc_id: 338668 cord_uid: z2z4gte2 file: cache/cord-338729-v2suoj3c.json key: cord-338729-v2suoj3c authors: Streicher, Caroline; Engalenc, Xavier; Gaudin, Marion; Vignaud, Guillaume; Daulange, Annick; Abraham, Bruno title: Could Tocilizumab be an Attractive Therapeutic Option for Elderly Patients with Severe COVID-19? A Case Report date: 2020-09-20 journal: Clin Drug Investig DOI: 10.1007/s40261-020-00969-5 sha: doc_id: 338729 cord_uid: v2suoj3c file: cache/cord-338683-nzgnpi6f.json key: cord-338683-nzgnpi6f authors: Karligkiotis, Apostolos; Arosio, Alberto D.; Battaglia, Paolo; Sileo, Giorgio; Czaczkes, Camilla; Volpi, Luca; Turri‐Zanoni, Mario; Castelnuovo, Paolo title: Changing paradigms in sinus and skull base surgery as the COVID‐19 pandemic evolves: Preliminary experience from a single Italian tertiary care center date: 2020-06-08 journal: Head Neck DOI: 10.1002/hed.26320 sha: doc_id: 338683 cord_uid: nzgnpi6f file: cache/cord-338346-e3fk6gz2.json key: cord-338346-e3fk6gz2 authors: Oliveros, Estefania; Brailovsky, Yevgeniy; Scully, Paul; Nikolou, Evgenia; Rajani, Ronak; Grapsa, Julia title: Coronavirus Disease 2019 and Heart Failure: A Multiparametric Approach date: 2020-08-14 journal: Card Fail Rev DOI: 10.15420/cfr.2020.09 sha: doc_id: 338346 cord_uid: e3fk6gz2 file: cache/cord-339406-81a7fkpj.json key: cord-339406-81a7fkpj authors: Borghi, M. O.; Beltagy, A.; Garrafa, E.; Curreli, D.; Cecchini, G.; Bodio, C.; Grossi, C.; Blengino, S.; Tincani, A.; Franceschini, F.; Andreoli, L.; Lazzaroni, M. G.; Piantoni, S.; Masneri, S.; Crisafulli, F.; Brugnoni, D.; Muiesan, M. L.; Salvetti, M.; Parati, G.; Torresani, E.; Mahler, M.; Heilbron, F.; Pregnolato, F.; Pengo, M.; Tedesco, F.; Pozzi, N.; Meroni, P. L. title: Prevalence, specificity, and clinical association of anti-phospholipid antibodies in COVID-19 patients: are the antibodies really guilty? date: 2020-06-19 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.06.17.20134114 sha: doc_id: 339406 cord_uid: 81a7fkpj file: cache/cord-338602-6n309bnp.json key: cord-338602-6n309bnp authors: Gadotti, Ana Carolina; de Castro Deus, Marina; Telles, Joao Paulo; Wind, Rafael; Goes, Marina; Garcia Charello Ossoski, Roberta; de Padua, Alessandra Michalski; Noronha, Lucia; Moreno-Amaral, Andrea; Baena, Cristina Pellegrino; Tuon, Felipe Francisco title: IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection date: 2020-09-23 journal: Virus Res DOI: 10.1016/j.virusres.2020.198171 sha: doc_id: 338602 cord_uid: 6n309bnp file: cache/cord-338023-gb5jgqcg.json key: cord-338023-gb5jgqcg authors: Obara, Shinju title: Anesthesiologist behavior and anesthesia machine use in the operating room during the COVID-19 pandemic: awareness and changes to cope with the risk of infection transmission date: 2020-08-27 journal: J Anesth DOI: 10.1007/s00540-020-02846-z sha: doc_id: 338023 cord_uid: gb5jgqcg file: cache/cord-339333-7tpnbr8q.json key: cord-339333-7tpnbr8q authors: CHEN, YUXIAN; ZENG, CHUN; ZENG, HUA; ZHANG, RONGKAI; YE, ZHIQIANG; XING, BANGRONG; HU, KUNHUA; LI, MINGTAO; CAI, DAO ZHANG title: Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults date: 2014-11-12 journal: Exp Ther Med DOI: 10.3892/etm.2014.2069 sha: doc_id: 339333 cord_uid: 7tpnbr8q file: cache/cord-338131-6y96eyoq.json key: cord-338131-6y96eyoq authors: Galvez, A.; King, K.; El Chaar, M.; Claros, L. title: Perforated Marginal Ulcer in a COVID-19 Patient. Laparoscopy in these Trying Times? date: 2020-05-24 journal: Obes Surg DOI: 10.1007/s11695-020-04709-8 sha: doc_id: 338131 cord_uid: 6y96eyoq file: cache/cord-338605-3i5pvcgu.json key: cord-338605-3i5pvcgu authors: Antoun, Lina; Taweel, Nashwa El; Ahmed, Irshad; Patni, Shalini; Honest, Honest title: Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome A prospective cohort study date: 2020-07-15 journal: Eur J Obstet Gynecol Reprod Biol DOI: 10.1016/j.ejogrb.2020.07.008 sha: doc_id: 338605 cord_uid: 3i5pvcgu file: cache/cord-338600-wpfcxnyu.json key: cord-338600-wpfcxnyu authors: Stewart, Cameron; Biegler, Paul; Brunero, Scott; Lamont, Scott; Tomossy, George F. title: Mental Capacity Assessments for COVID-19 Patients: Emergency Admissions and the CARD Approach date: 2020-11-09 journal: J Bioeth Inq DOI: 10.1007/s11673-020-10055-2 sha: doc_id: 338600 cord_uid: wpfcxnyu file: cache/cord-339455-b8nu34vv.json key: cord-339455-b8nu34vv authors: Sakr, Yasser; Giovini, Manuela; Leone, Marc; Pizzilli, Giacinto; Kortgen, Andreas; Bauer, Michael; Tonetti, Tommaso; Duclos, Gary; Zieleskiewicz, Laurent; Buschbeck, Samuel; Ranieri, V. Marco; Antonucci, Elio title: The clinical spectrum of pulmonary thromboembolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: A European case series date: 2020-09-25 journal: J Crit Care DOI: 10.1016/j.jcrc.2020.09.021 sha: doc_id: 339455 cord_uid: b8nu34vv file: cache/cord-339267-p3djwg7v.json key: cord-339267-p3djwg7v authors: Taylor, Sally; Johnson, Helen; Peat, Sara; Booker, Jane; Yorke, Janelle title: Exploring the experiences of patients, general practitioners and oncologists of prostate cancer follow-up: A qualitative interview study date: 2020-08-01 journal: Eur J Oncol Nurs DOI: 10.1016/j.ejon.2020.101820 sha: doc_id: 339267 cord_uid: p3djwg7v file: cache/cord-337965-z39q8ebq.json key: cord-337965-z39q8ebq authors: Kvernland, Alexandra; Kumar, Arooshi; Yaghi, Shadi; Raz, Eytan; Frontera, Jennifer; Lewis, Ariane; Czeisler, Barry; Kahn, D. Ethan; Zhou, Ting; Ishida, Koto; Torres, Jose; Riina, Howard A.; Shapiro, Maksim; Nossek, Erez; Nelson, Peter K.; Tanweer, Omar; Gordon, David; Jain, Rajan; Dehkharghani, Seena; Henninger, Nils; de Havenon, Adam; Grory, Brian Mac; Lord, Aaron; Melmed, Kara title: Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System date: 2020-08-24 journal: Neurocrit Care DOI: 10.1007/s12028-020-01077-0 sha: doc_id: 337965 cord_uid: z39q8ebq file: cache/cord-338182-cetv78ba.json key: cord-338182-cetv78ba authors: Zurita-Cruz, Jessie; Gutierrez-Gonzalez, Alejandro; Manuel-Apolinar, Leticia; Fernández-Gárate, José Esteban; Arellano-Flores, María Luisa; Correa Gonzalez, Roberto Alejandro; Vázquez-Rosales, Guillermo; Pérez Vieyra, Patricia; Sanchez-Armas, Rocio; Cisneros-González, Nelly title: The Impact of a History of Pre-maturity on Viral Respiratory Infections in Children Under 2 Years of Age: A Propensity Score-Matching Analysis of in-hospital Complications and Mortality date: 2020-09-18 journal: Front Pediatr DOI: 10.3389/fped.2020.499013 sha: doc_id: 338182 cord_uid: cetv78ba file: cache/cord-338419-n8cmv8mf.json key: cord-338419-n8cmv8mf authors: Carmelo, Juliana de Carvalho; Alves, Tatielly Karine Costa; Khouri, Micheline Salim; da Mata Santos, Rafael Pereira; Rodrigues, Lizandra Gonzaga; Alvarez-Leite, Maria Eugenia; Manzi, Flávio Ricardo title: Impact of COVID-19 on the daily routine of radiology clinics date: 2020-09-16 journal: Imaging Sci Dent DOI: 10.5624/isd.2020.50.3.261 sha: doc_id: 338419 cord_uid: n8cmv8mf file: cache/cord-339467-ewqxf02j.json key: cord-339467-ewqxf02j authors: Liang, Ying; Liang, Jing-Jin; Zhou, Qing-Tao; Li, Xiao-Guang; Lin, Fei; Deng, Zhong-Hua; Zhang, Bi-Ying; Li, Lu; Wang, Xiao-Hua; Zhu, Hong; Ma, Qing-Bian; Tong, Xiao-Mei; Xu, Jie; Sun, Yong-Chang title: Differential diagnosis of coronavirus disease 2019 from pneumonias caused by other etiologies in a fever clinic in Beijing date: 2020-10-20 journal: Chin Med J (Engl) DOI: 10.1097/cm9.0000000000001121 sha: doc_id: 339467 cord_uid: ewqxf02j file: cache/cord-338965-ewuqsfsf.json key: cord-338965-ewuqsfsf authors: Alotaibi, Fawzia E.; Bukhari, Elham E.; Al-Mohizea, Maha M.; Hafiz, Taghreed; Essa, Eman B.; AlTokhais, Yasmeen I. title: Emergence of carbapenem-resistant Enterobacteriaceae isolated from patients in a university hospital in Saudi Arabia. Epidemiology, clinical profiles and outcomes date: 2017-06-20 journal: J Infect Public Health DOI: 10.1016/j.jiph.2017.05.004 sha: doc_id: 338965 cord_uid: ewuqsfsf file: cache/cord-339266-glmshsh6.json key: cord-339266-glmshsh6 authors: Yin, R.; Yang, Z.; Wei, Y.; Li, Y.; Chen, H.; Ma, D.; Dan, M.; Zhang, Y.; Liu, X.; Leng, H.; Xiang, D. title: Clinical characteristics of 106 patients with neurological diseases and co-morbid coronavirus disease 2019: a retrospective study date: 2020-05-05 journal: nan DOI: 10.1101/2020.04.29.20085415 sha: doc_id: 339266 cord_uid: glmshsh6 file: cache/cord-339614-28s205p8.json key: cord-339614-28s205p8 authors: Dover, Jeffrey S.; Moran, Mary Lynn; Figueroa, Jose F.; Furnas, Heather; Vyas, Jatin M.; Wiviott, Lory D.; Karchmer, Adolf W. title: A Path to Resume Aesthetic Care: Executive Summary of Project AesCert Guidance Supplement—Practical Considerations for Aesthetic Medicine Professionals Supporting Clinic Preparedness in Response to the SARS-CoV-2 Outbreak date: 2020-05-01 journal: Facial Plast Surg Aesthet Med DOI: 10.1089/fpsam.2020.0239 sha: doc_id: 339614 cord_uid: 28s205p8 file: cache/cord-338756-jzz250o1.json key: cord-338756-jzz250o1 authors: Zhang, Nan; Yao, Haochen; Zhang, Dong; Pan, Jiahui; Peng, Ejun; Huang, Juanjuan; Zhang, Yingli; Xu, Xiaoming; Tian, Guobao; Xu, Hong; Wang, Guoqing title: Epidemiologic and clinical characteristics of 42 deaths caused by SARS-CoV-2 infection in Wuhan, China: A retrospective study date: 2020-07-15 journal: Biosaf Health DOI: 10.1016/j.bsheal.2020.07.007 sha: doc_id: 338756 cord_uid: jzz250o1 file: cache/cord-338741-gy3ovkrt.json key: cord-338741-gy3ovkrt authors: Sethi, Atin; Bach, Horacio title: Evaluation of Current Therapies for COVID-19 Treatment date: 2020-07-22 journal: Microorganisms DOI: 10.3390/microorganisms8081097 sha: doc_id: 338741 cord_uid: gy3ovkrt file: cache/cord-339517-93nuovsj.json key: cord-339517-93nuovsj authors: Consolo, Ugo; Bellini, Pierantonio; Bencivenni, Davide; Iani, Cristina; Checchi, Vittorio title: Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia date: 2020-05-15 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17103459 sha: doc_id: 339517 cord_uid: 93nuovsj file: cache/cord-339436-0k73tlna.json key: cord-339436-0k73tlna authors: Giagulli, Vito Angelo; Guastamacchia, Edoardo; Magrone, Thea; Jirillo, Emilio; Lisco, Giuseppe; De Pergola, Giovanni; Triggiani, Vincenzo title: Worse progression of COVID‐19 in men: Is Testosterone a key factor? date: 2020-06-11 journal: Andrology DOI: 10.1111/andr.12836 sha: doc_id: 339436 cord_uid: 0k73tlna file: cache/cord-339474-tsdq1rgz.json key: cord-339474-tsdq1rgz authors: Rosen, Tony; Ferrante, Lauren E.; Liu, Shan W.; Benton, Emily A.; Mulcare, Mary R.; Stern, Michael E.; Biese, Kevin; Hwang, Ula; Sanon, Martine title: Managing Older Adults with Presumed COVID‐19 in the Emergency Department: A Rational Approach to Rationing date: 2020-07-13 journal: J Am Geriatr Soc DOI: 10.1111/jgs.16651 sha: doc_id: 339474 cord_uid: tsdq1rgz file: cache/cord-339568-th2xmhb6.json key: cord-339568-th2xmhb6 authors: Yan, Meitian; Zheng, Yutong; Sun, Yanmei; Wang, Lan; Luan, Liang; Liu, Jing; Tian, Xiao; Wan, Nan title: Analysis of the diagnostic value of serum specific antibody testing for coronavirus disease 2019 date: 2020-06-27 journal: J Med Virol DOI: 10.1002/jmv.26230 sha: doc_id: 339568 cord_uid: th2xmhb6 file: cache/cord-339737-7qdjea6f.json key: cord-339737-7qdjea6f authors: Sbidian, E.; Josse, J.; Lemaitre, G.; Mayer, I.; Bernaux, M.; Gramfort, A.; Lapidus, N.; Paris, N.; Neuraz, A.; Lerner, I.; Garcelon, N.; Rance, B.; Grisel, O.; Moreau, T.; Bellamine, A.; Wolkenstein, P.; Varoquaux, G.; Caumes, E.; Lavielle, M.; Mekontso Dessap, A.; Audureau, E. title: Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France date: 2020-06-19 journal: nan DOI: 10.1101/2020.06.16.20132597 sha: doc_id: 339737 cord_uid: 7qdjea6f file: cache/cord-339940-80757pwu.json key: cord-339940-80757pwu authors: Zaidi, S. Javed; Schweig, Lorene; Patel, Dhaval; Javois, Alexander; Akhter, Javeed title: A novel approach to the diagnosis and treatment of hemoptysis in infants: A case series date: 2018-09-18 journal: Pediatr Pulmonol DOI: 10.1002/ppul.24160 sha: doc_id: 339940 cord_uid: 80757pwu file: cache/cord-339009-wcoch07b.json key: cord-339009-wcoch07b authors: File, Thomas M.; Tsang, Kenneth W. T. title: Severe Acute Respiratory Syndrome: Pertinent Clinical Characteristics and Therapy date: 2012-08-23 journal: Treat Respir Med DOI: 10.2165/00151829-200504020-00003 sha: doc_id: 339009 cord_uid: wcoch07b file: cache/cord-339589-dl2qpc0t.json key: cord-339589-dl2qpc0t authors: Thachil, Jecko; Srivastava, Alok title: SARS-2 Coronavirus–Associated Hemostatic Lung Abnormality in COVID-19: Is It Pulmonary Thrombosis or Pulmonary Embolism? date: 2020-05-12 journal: Semin Thromb Hemost DOI: 10.1055/s-0040-1712155 sha: doc_id: 339589 cord_uid: dl2qpc0t file: cache/cord-339811-dms0rlmr.json key: cord-339811-dms0rlmr authors: Choudhury, Noura; Shoushtari, Alexander title: Training Oncologists in the Time of COVID‐19 date: 2020-06-05 journal: Oncologist DOI: 10.1634/theoncologist.2020-0373 sha: doc_id: 339811 cord_uid: dms0rlmr file: cache/cord-339044-qy4jab37.json key: cord-339044-qy4jab37 authors: Li, Man; Cheng, Biao; Zeng, Wen; Chen, Sichao; Tu, Mengqi; Wu, Meng; Tong, Wei; Wang, Shipei; Huang, Yihui; Long, Wei; Zhou, Wei; Chen, Danyang; Zhou, Lin; Wang, Min; Xu, Haibo; Deng, Aiping; Liu, Zeming; Guo, Liang title: Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study date: 2020-08-25 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00545 sha: doc_id: 339044 cord_uid: qy4jab37 file: cache/cord-339471-1510mzmy.json key: cord-339471-1510mzmy authors: Ikizler, T. Alp title: COVID-19 in Dialysis Patients: Adding a Few More Pieces to the Puzzle date: 2020-05-08 journal: Kidney Int DOI: 10.1016/j.kint.2020.04.032 sha: doc_id: 339471 cord_uid: 1510mzmy file: cache/cord-339679-9hghy9pd.json key: cord-339679-9hghy9pd authors: Gurley, Emily S.; Montgomery, Joel M.; Hossain, M. Jahangir; Bell, Michael; Azad, Abul Kalam; Islam, Mohammed Rafiqul; Molla, Mohammed Abdur Rahim; Carroll, Darin S.; Ksiazek, Thomas G.; Rota, Paul A.; Lowe, Luis; Comer, James A.; Rollin, Pierre; Czub, Markus; Grolla, Allen; Feldmann, Heinz; Luby, Stephen P.; Woodward, Jennifer L.; Breiman, Robert F. title: Person-to-Person Transmission of Nipah Virus in a Bangladeshi Community date: 2007-07-17 journal: Emerg Infect Dis DOI: 10.3201/eid1307.061128 sha: doc_id: 339679 cord_uid: 9hghy9pd file: cache/cord-340000-1e66aqih.json key: cord-340000-1e66aqih authors: Ho, Ivy K.; Lawrence, Jason S. title: The Role of Social Cognition in Medical Decision Making with Asian American Patients date: 2020-09-14 journal: J Racial Ethn Health Disparities DOI: 10.1007/s40615-020-00867-8 sha: doc_id: 340000 cord_uid: 1e66aqih file: cache/cord-339355-zkkj8a83.json key: cord-339355-zkkj8a83 authors: Siripanthong, Bhurint; Hanff, Thomas C; Levin, Michael G; Vidula, Mahesh K; Khanji, Mohammed Y; Nazarian, Saman; Chahal, Choudhary Anwar A title: Coronavirus disease 2019 is delaying the diagnosis and management of chest pain, acute coronary syndromes, myocarditis and heart failure date: 2020-07-01 journal: Future cardiology DOI: 10.2217/fca-2020-0088 sha: doc_id: 339355 cord_uid: zkkj8a83 file: cache/cord-340051-r9kn34wd.json key: cord-340051-r9kn34wd authors: MEI, Xue; ZHANG, Yuyi; ZHU, Hui; LING, Yun; ZOU, Ying; ZHANG, Zhengguo; GUO, Hongying; LIU, Yu; CHENG, Xingxia; LIU, Min; HUANG, Wei; WANG, Jiefei; YI, Zhigang; QIAN, Zhiping; LU, Hongzhou title: Observations about Symptomatic and Asymptomatic infections of 494 patients with COVID-19 in Shanghai,China date: 2020-07-06 journal: Am J Infect Control DOI: 10.1016/j.ajic.2020.06.221 sha: doc_id: 340051 cord_uid: r9kn34wd file: cache/cord-335802-1kiqfy68.json key: cord-335802-1kiqfy68 authors: Azoulay, Elie; Fartoukh, Muriel; Darmon, Michael; Géri, Guillaume; Voiriot, Guillaume; Dupont, Thibault; Zafrani, Lara; Girodias, Lola; Labbé, Vincent; Dres, Martin; Beurton, Alexandra; Vieillard-Baron, Antoine; Demoule, Alexandre title: Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset date: 2020-08-11 journal: Intensive Care Med DOI: 10.1007/s00134-020-06202-3 sha: doc_id: 335802 cord_uid: 1kiqfy68 file: cache/cord-340164-vzdyy656.json key: cord-340164-vzdyy656 authors: Karimi, Zohreh; Fereidouni, Zhila; Behnammoghadam, Mohammad; Alimohammadi, Nasrollah; Mousavizadeh, Ali; Salehi, Tahmine; Mirzaee, Mohammad Saeed; Mirzaee, Sobhan title: The Lived Experience of Nurses Caring for Patients with COVID-19 in Iran: A Phenomenological Study date: 2020-08-20 journal: Risk Manag Healthc Policy DOI: 10.2147/rmhp.s258785 sha: doc_id: 340164 cord_uid: vzdyy656 file: cache/cord-339705-x8l3zgfd.json key: cord-339705-x8l3zgfd authors: Patil, Vijaykumar; Ingle, D. R. title: An association between fingerprint patterns with blood group and lifestyle based diseases: a review date: 2020-08-18 journal: Artif Intell Rev DOI: 10.1007/s10462-020-09891-w sha: doc_id: 339705 cord_uid: x8l3zgfd file: cache/cord-339913-ps4nvvaz.json key: cord-339913-ps4nvvaz authors: Ma, Min; Yang, Zhi-gang; He, Yong title: How cardiologists respond to COVID-19: the experience of West China Hospital, China date: 2020-07-16 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02413-0 sha: doc_id: 339913 cord_uid: ps4nvvaz file: cache/cord-339956-o5o2yz1u.json key: cord-339956-o5o2yz1u authors: Albahri, O.S.; Al-Obaidi, Jameel R.; Zaidan, A.A.; Albahri, A.S.; Zaidan, B.B.; Sali, M.M.; Abdlhadi, A.; Dawood, K.A.; Mohammed, R.T.; Abdulkareem, Karrar Hameed; Aleesa, A.M.; Alamoodi, A.H.; Chyad, M.A.; Zulkifli, Che Zalina title: Helping Doctors Hasten COVID-19 Treatment: Towards a Rescue Framework for the Transfusion of Best Convalescent Plasma to the Most Critical Patients based on Biological Requirements via ML and Novel MCDM Methods date: 2020-06-20 journal: Comput Methods Programs Biomed DOI: 10.1016/j.cmpb.2020.105617 sha: doc_id: 339956 cord_uid: o5o2yz1u file: cache/cord-339686-oybnk1j8.json key: cord-339686-oybnk1j8 authors: Suassuna, José Hermógenes Rocco; de Lima, Emerson Quintino; Rocha, Eduardo; Castro, Alan; Burdmann, Emmanuel de Almeida; do Carmo, Lilian Pires de Freitas; Yu, Luis; Ibrahim, Mauricio Younes; Betônico, Gustavo Navarro; Cuvello, Américo Lourenço; Ávila, Maria Olinda Nogueira; Gonçalvez, Anderson R. Roman; Costa, Ciro Bruno Silveira; Bresolin, Nilzete Liberato; de Abreu, Andrea Pio; Lobo, Suzana Margareth Ajeje; do Nascimento, Marcelo Mazza title: Technical note and clinical instructions for Acute Kidney Injury (AKI) in patients with Covid-19: Brazilian Society of Nephrology and Brazilian Association of Intensive Care Medicine date: 2020-08-26 journal: J Bras Nefrol DOI: 10.1590/2175-8239-jbn-2020-s107 sha: doc_id: 339686 cord_uid: oybnk1j8 file: cache/cord-339504-8svo2w3u.json key: cord-339504-8svo2w3u authors: Lima, Rodrigo Moreira e; Reis, Leonardo de Andrade; Lara, Felipe Thyrso de Souza; Dias, Lino Correa; Matsumoto, Márcio; Mizubuti, Glenio; Hamaji, Adilson; Cabral, Lucas Wynne; Mathias, Lígia Andrade da Silva Telles; Lima, Lais Helena Navarro e title: Recommendations for local-regional anesthesia during the COVID-19 pandemic date: 2020-06-10 journal: Braz J Anesthesiol DOI: 10.1016/j.bjane.2020.06.002 sha: doc_id: 339504 cord_uid: 8svo2w3u file: cache/cord-339656-u0cpklsv.json key: cord-339656-u0cpklsv authors: de Groot-Mijnes, Jolanda D.F.; de Visser, Lenneke; Zuurveen, Stephanie; Martinus, Roaldy A.; Völker, René; ten Dam-van Loon, Ninette H.; de Boer, Joke H.; Postma, Gina; de Groot, Raoul J.; van Loon, Anton M.; Rothova, Aniki title: Identification of New Pathogens in the Intraocular Fluid of Patients With Uveitis date: 2010-11-30 journal: American Journal of Ophthalmology DOI: 10.1016/j.ajo.2010.05.015 sha: doc_id: 339656 cord_uid: u0cpklsv file: cache/cord-339885-mpzgrogd.json key: cord-339885-mpzgrogd authors: Zhan, Yangqing; Yang, Zifeng; Chen, Rongchang; Wang, Yutao; Guan, Wenda; Zhao, Suishan title: Respiratory virus is a real pathogen in immunocompetent community-acquired pneumonia: comparing to influenza like illness and volunteer controls date: 2014-09-02 journal: BMC Pulm Med DOI: 10.1186/1471-2466-14-144 sha: doc_id: 339885 cord_uid: mpzgrogd file: cache/cord-339695-3ij5pjjy.json key: cord-339695-3ij5pjjy authors: Nopp, Stephan; Moik, Florian; Jilma, Bernd; Pabinger, Ingrid; Ay, Cihan title: Risk of venous thromboembolism in patients with COVID‐19: A systematic review and meta‐analysis date: 2020-09-25 journal: Res Pract Thromb Haemost DOI: 10.1002/rth2.12439 sha: doc_id: 339695 cord_uid: 3ij5pjjy file: cache/cord-340070-de7sfccy.json key: cord-340070-de7sfccy authors: Pérez-Martinez, Antonio; Guerra-García, Pilar; Melgosa, Marta; Frauca, Esteban; Fernandez-Camblor, Carlota; Remesal, Agustin; Calvo, Cristina title: Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain date: 2020-08-29 journal: Eur J Pediatr DOI: 10.1007/s00431-020-03793-3 sha: doc_id: 340070 cord_uid: de7sfccy file: cache/cord-340204-3gm58qza.json key: cord-340204-3gm58qza authors: Mahmoodpoor, Ata; Shadvar, Kamran; Ghamari, Ali Akbar; Mohammadzadeh Lameh, Mojtaba; Asghari Ardebili, Roghayeh; Hamidi, Masood; Soleimanpour, Hassan title: Management of Critically Ill Patients with COVID-19: What We Learned and What We Do date: 2020-06-10 journal: Anesth Pain Med DOI: 10.5812/aapm.104900 sha: doc_id: 340204 cord_uid: 3gm58qza file: cache/cord-340232-cadu5ah8.json key: cord-340232-cadu5ah8 authors: Aliter, Kholoud F.; Al-Horani, Rami A. title: Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19 date: 2020-09-01 journal: Cardiovasc Drugs Ther DOI: 10.1007/s10557-020-07066-x sha: doc_id: 340232 cord_uid: cadu5ah8 file: cache/cord-340314-5oz3013n.json key: cord-340314-5oz3013n authors: Mazzitelli, Maria; Arrighi, Eugenio; Serapide, Francesca; Pelle, Maria Chiara; Tassone, Bruno; Lionello, Rosaria; Marrazzo, Giuseppina; Laganà, Domenico; Costanzo, Francesco Saverio; Matera, Giovanni; Trecarichi, Enrico Maria; Torti, Carlo title: Use of subcutaneous tocilizumab in patients with COVID‐19 pneumonia date: 2020-05-15 journal: J Med Virol DOI: 10.1002/jmv.26016 sha: doc_id: 340314 cord_uid: 5oz3013n file: cache/cord-340253-lpner9f8.json key: cord-340253-lpner9f8 authors: D’Amario, Domenico; Camilli, Massimiliano; Migliaro, Stefano; Canonico, Francesco; Galli, Mattia; Arcudi, Alessandra; Montone, Rocco Antonio; Borovac, Josip Andjelo; Crea, Filippo; Savarese, Gianluigi title: Sex-Related Differences in Dilated Cardiomyopathy with a Focus on Cardiac Dysfunction in Oncology date: 2020-08-08 journal: Curr Cardiol Rep DOI: 10.1007/s11886-020-01377-z sha: doc_id: 340253 cord_uid: lpner9f8 file: cache/cord-340383-psjga23p.json key: cord-340383-psjga23p authors: Simpson, Brenda Baird; Whitt, Maria O.; Berger, Linda title: Patient Care Services Staffing Support During a Pandemic date: 2020-10-01 journal: Nurse Lead DOI: 10.1016/j.mnl.2020.07.005 sha: doc_id: 340383 cord_uid: psjga23p file: cache/cord-340415-6fte7krp.json key: cord-340415-6fte7krp authors: Thevarajan, Irani; Buising, Kirsty L; Cowie, Benjamin C title: Clinical presentation and management of COVID‐19 date: 2020-07-17 journal: Med J Aust DOI: 10.5694/mja2.50698 sha: doc_id: 340415 cord_uid: 6fte7krp file: cache/cord-340650-mwsa326c.json key: cord-340650-mwsa326c authors: Elangovan, E. J.; Kumar, V. S.; Kathiravan, A.; Mallampalli, R.; Thomas, T.; Subramaniyam, G. title: Rationale and prognosis of repurposed drugs with risk stratification of patients in oxygen support in COVID-19: A systematic review and meta-analysis date: 2020-10-06 journal: nan DOI: 10.1101/2020.10.04.20206516 sha: doc_id: 340650 cord_uid: mwsa326c file: cache/cord-340660-ocvy1ge2.json key: cord-340660-ocvy1ge2 authors: Mehmood, Maham A; Patel, Madanmohan; Sanekommu, Harshavardhan title: Methicillin-Resistant Staphylococcus Aureus: A Very Rare Cause of Meningitis date: 2020-09-10 journal: Cureus DOI: 10.7759/cureus.10370 sha: doc_id: 340660 cord_uid: ocvy1ge2 file: cache/cord-340576-dabcs3w5.json key: cord-340576-dabcs3w5 authors: Nishikawa, Hiroki; Enomoto, Hirayuki; Nishiguchi, Shuhei; Iijima, Hiroko title: Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis date: 2020-07-24 journal: Int J Mol Sci DOI: 10.3390/ijms21155254 sha: doc_id: 340576 cord_uid: dabcs3w5 file: cache/cord-340430-x4oitcyh.json key: cord-340430-x4oitcyh authors: Horgan, T. J.; Alsabbagh, A. Y.; McGoldrick, D. M.; Bhatia, S. K.; Messahel, A. title: Oral and Maxillofacial Surgery Patient Satisfaction with Telephone Consultations during the COVID-19 pandemic date: 2020-08-25 journal: Br J Oral Maxillofac Surg DOI: 10.1016/j.bjoms.2020.08.099 sha: doc_id: 340430 cord_uid: x4oitcyh file: cache/cord-340799-1awmtj52.json key: cord-340799-1awmtj52 authors: Krajewska, Joanna; Krajewski, Wojciech; Zub, Krzysztof; Zatoński, Tomasz title: Review of practical recommendations for otolaryngologists and head and neck surgeons during the COVID-19 pandemic: Recommendations for otolaryngologists during the COVID-19 pandemic date: 2020-06-06 journal: Auris Nasus Larynx DOI: 10.1016/j.anl.2020.05.022 sha: doc_id: 340799 cord_uid: 1awmtj52 file: cache/cord-340826-2530zdeq.json key: cord-340826-2530zdeq authors: Hwang, Jong-moon; Kim, Ju-Hyun; Park, Jin-Sung; Chang, Min Cheol; Park, Donghwi title: Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study date: 2020-07-08 journal: Neurol Sci DOI: 10.1007/s10072-020-04541-z sha: doc_id: 340826 cord_uid: 2530zdeq file: cache/cord-340687-99ad1rwq.json key: cord-340687-99ad1rwq authors: Abourida, Yassamine; Rebahi, Houssam; Oussayeh, Imane; Chichou, Hajar; Fakhir, Bouchra; Soummani, Abderraouf; Jalal, Hicham; Bennaoui, Fatiha; Slitine, Nadia El Idrissi; Maoulainine, Fadl Mrabih Rabou; El Adib, Ahmed Rhassane; Samkaoui, Mohamed Abdenacer title: Management of Severe COVID-19 in Pregnancy date: 2020-07-27 journal: Case Rep Obstet Gynecol DOI: 10.1155/2020/8852816 sha: doc_id: 340687 cord_uid: 99ad1rwq file: cache/cord-340651-g3518bq2.json key: cord-340651-g3518bq2 authors: Hsu, Chung-Hua; Hwang, Kung-Chang; Chao, Chung-Liang; Chang, Steve G. N.; Ho, Mei-Shang; Lin, Jaung-Geng; Chang, Hen-Hong; Kao, Shung-Te; Chen, Yi-Ming; Chou, Pesus title: An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study date: 2007-05-29 journal: Evid Based Complement Alternat Med DOI: 10.1093/ecam/nem035 sha: doc_id: 340651 cord_uid: g3518bq2 file: cache/cord-340786-12vzsl6p.json key: cord-340786-12vzsl6p authors: Pinto, Susana; Quintarelli, Stefano; Silani, Vincenzo title: New technologies and Amyotrophic Lateral Sclerosis – Which step forward rushed by the COVID-19 pandemic? date: 2020-08-05 journal: J Neurol Sci DOI: 10.1016/j.jns.2020.117081 sha: doc_id: 340786 cord_uid: 12vzsl6p file: cache/cord-340766-aic570x8.json key: cord-340766-aic570x8 authors: Kim, Se Jin; Kim, Kang; Park, Sung Bum; Hong, Duck Jin; Jhun, Byung Woo title: Outcomes of Early Administration of Cidofovir in Non-Immunocompromised Patients with Severe Adenovirus Pneumonia date: 2015-04-15 journal: PLoS One DOI: 10.1371/journal.pone.0122642 sha: doc_id: 340766 cord_uid: aic570x8 file: cache/cord-340536-azlajqbe.json key: cord-340536-azlajqbe authors: Bartolo, Michelangelo; Intiso, Domenico; Lentino, Carmelo; Sandrini, Giorgio; Paolucci, Stefano; Zampolini, Mauro title: Urgent Measures for the Containment of the Coronavirus (Covid-19) Epidemic in the Neurorehabilitation/Rehabilitation Departments in the Phase of Maximum Expansion of the Epidemic date: 2020-04-30 journal: Front Neurol DOI: 10.3389/fneur.2020.00423 sha: doc_id: 340536 cord_uid: azlajqbe file: cache/cord-340811-w4x4falm.json key: cord-340811-w4x4falm authors: Frizzelli, Annalisa; Tuttolomondo, Domenico; Aiello, Marina; Majori, Maria; Bertorelli, Giuseppina; Chetta, Alfredo title: What happens to people’s lungs when they get coronavirus disease 2019? date: 2020-05-11 journal: Acta Biomed DOI: 10.23750/abm.v91i2.9574 sha: doc_id: 340811 cord_uid: w4x4falm file: cache/cord-340908-8q7i5ds3.json key: cord-340908-8q7i5ds3 authors: D’Ambrosi, Riccardo; Biazzo, Alessio; Masia, Francesco; Izzo, Vincenzo; Confalonieri, Norberto; Ursino, Nicola; Verde, Francesco title: Guidelines for Resuming Elective Hip and Knee Surgical Activity Following the COVID-19 Pandemic: An Italian Perspective date: 2020-10-13 journal: HSS J DOI: 10.1007/s11420-020-09809-w sha: doc_id: 340908 cord_uid: 8q7i5ds3 file: cache/cord-342555-5r9aa7u5.json key: cord-342555-5r9aa7u5 authors: Eghtesadi, Marzieh title: Breaking Social Isolation Amidst COVID‐19: A Viewpoint on Improving Access to Technology in Long‐Term Care Facilities date: 2020-04-24 journal: J Am Geriatr Soc DOI: 10.1111/jgs.16478 sha: doc_id: 342555 cord_uid: 5r9aa7u5 file: cache/cord-341202-1pg7rq2d.json key: cord-341202-1pg7rq2d authors: Manicone, Francesca; Landi, Rossella; Martinino, Alessandro title: The last bed dilemma burns out COVID-19 triage: a viewpoint from Medical and Law students date: 2020-08-12 journal: nan DOI: 10.1016/j.lpmfor.2020.08.004 sha: doc_id: 341202 cord_uid: 1pg7rq2d file: cache/cord-340542-jz7ca041.json key: cord-340542-jz7ca041 authors: Lara Álvarez, Miguel Ángel; Revuelta, Jacobo Rogado; Portero, Berta Obispo; Méndez, Cristina Pangua; Montero, Gloria Serrano; Alfonso, Ana López title: Covid-19 mortality in cancer patients in a Madrid hospital during the first 3 weeks of the epidemic date: 2020-08-03 journal: Med Clin (Engl Ed) DOI: 10.1016/j.medcle.2020.05.012 sha: doc_id: 340542 cord_uid: jz7ca041 file: cache/cord-341415-g781zhu6.json key: cord-341415-g781zhu6 authors: Jhaveri, Kenar D.; Meir, Lea R.; Flores Chang, Bessy Suyin; Parikh, Rushang; Wanchoo, Rimda; Barilla-LaBarca, Marie Louise; Bijol, Vanesa; Hajizadeh, Negin title: Thrombotic microangiopathy in a patient with COVID-19 date: 2020-06-07 journal: Kidney Int DOI: 10.1016/j.kint.2020.05.025 sha: doc_id: 341415 cord_uid: g781zhu6 file: cache/cord-341627-21m8rdhy.json key: cord-341627-21m8rdhy authors: Buda, Natalia; Segura-Grau, Elena; Cylwik, Jolanta; Wełnicki, Marcin title: Lung ultrasound in the diagnosis of COVID-19 infection - A case series and review of the literature date: 2020-06-25 journal: Adv Med Sci DOI: 10.1016/j.advms.2020.06.005 sha: doc_id: 341627 cord_uid: 21m8rdhy file: cache/cord-340880-2qop8tcp.json key: cord-340880-2qop8tcp authors: Hyman, Jaime B.; Leibner, Evan S.; Tandon, Pranai; Egorova, Natalia N.; Bassily-Marcus, Adel; Kohli-Seth, Roopa; Arvind, Varun; Chang, Helena L.; Lin, Hung-Mo; Levin, Matthew A. title: Timing of Intubation and In-Hospital Mortality in Patients With Coronavirus Disease 2019 date: 2020-10-21 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000254 sha: doc_id: 340880 cord_uid: 2qop8tcp file: cache/cord-341531-w788qwya.json key: cord-341531-w788qwya authors: Montero Feijoo, A.; Maseda, E.; Adalia Bartolomé, R.; Aguilar, G.; González de Castro, R.; Gómez-Herreras, J. I.; García Palenciano, C.; Pereira, J.; Ramasco Rueda, F.; Samso, E.; Suárez de la Rica, A.; Tamayo Medel, G.; Varela Durán, M. title: Practical recommendations for the perioperative management of patients with suspicion or serious infection by coronavirus SARS-CoV date: 2020-05-04 journal: nan DOI: 10.1016/j.redare.2020.03.002 sha: doc_id: 341531 cord_uid: w788qwya file: cache/cord-341118-h5t87vf8.json key: cord-341118-h5t87vf8 authors: Torres‐Navarro, Ignacio; Abril‐Pérez, Carlos; Roca‐Ginés, Juncal; Sánchez‐Arráez, Javier; Botella‐Estrada, Rafael title: A case of cefditoren‐induced Acute Generalized Exanthematous Pustulosis during COVID‐19 pandemics. Severe Cutaneous Adverse Reactions (SCARs) are an issue date: 2020-05-26 journal: J Eur Acad Dermatol Venereol DOI: 10.1111/jdv.16664 sha: doc_id: 341118 cord_uid: h5t87vf8 file: cache/cord-340710-dmow5p7k.json key: cord-340710-dmow5p7k authors: Lagana, Stephen M.; Kudose, Satoru; Iuga, Alina C.; Lee, Michael J.; Fazlollahi, Ladan; Remotti, Helen E.; Del Portillo, Armando; De Michele, Simona; de Gonzalez, Anne Koehne; Saqi, Anjali; Khairallah, Pascale; Chong, Alexander M.; Park, Heekuk; Uhlemann, Anne-Catrin; Lefkowitch, Jay H.; Verna, Elizabeth C. title: Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data date: 2020-08-13 journal: Mod Pathol DOI: 10.1038/s41379-020-00649-x sha: doc_id: 340710 cord_uid: dmow5p7k file: cache/cord-342810-41dghl0c.json key: cord-342810-41dghl0c authors: Nguyen, Thanh N.; Jadhav, Ashutosh P.; Dasenbrock, Hormuzdiyar H.; Nogueira, Raul G.; Abdalkader, Mohamad; Ma, Alice; Cervantes-Arslanian, Anna M.; Greer, David M.; Daneshmand, Ali; Yavagal, Dileep R.; Jovin, Tudor G.; Zaidat, Osama O.; Chou, Sherry Hsiang-Yi title: Subarachnoid hemorrhage guidance in the era of the COVID-19 pandemic -An opinion to mitigate exposure and conserve personal protective equipment date: 2020-06-05 journal: J Stroke Cerebrovasc Dis DOI: 10.1016/j.jstrokecerebrovasdis.2020.105010 sha: doc_id: 342810 cord_uid: 41dghl0c file: cache/cord-342246-tnjtd9n3.json key: cord-342246-tnjtd9n3 authors: Özçelik Korkmaz, Müge; Eğilmez, Oğuz Kadir; Özçelik, Muhammet Ali; Güven, Mehmet title: Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection date: 2020-10-03 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06396-8 sha: doc_id: 342246 cord_uid: tnjtd9n3 file: cache/cord-341197-e8m4oxma.json key: cord-341197-e8m4oxma authors: Soleimani, Abbas; Kazemian, Sina; Karbalai Saleh, Shahrokh; Aminorroaya, Arya; Shajari, Zahra; Hadadi, Azar; Talebpour, Mohammad; Sadeghian, Hakimeh; Payandemehr, Pooya; Sotoodehnia, Mehran; Bahreini, Maryam; Najmeddin, Farhad; Heidarzadeh, Ali; Zivari, Ensieh; Ashraf, Haleh title: Effects of angiotensin receptor blockers (ARBs) on in-hospital outcomes of patients with hypertension and confirmed or clinically suspected COVID-19 date: 2020-09-12 journal: Am J Hypertens DOI: 10.1093/ajh/hpaa149 sha: doc_id: 341197 cord_uid: e8m4oxma file: cache/cord-342303-ddulfe06.json key: cord-342303-ddulfe06 authors: Ismael, Julia; Losco, Federico; Quildrian, Sergio; Sanchez, Pablo; Pincemin, Isabel; Lastiri, Jose; Bella, Santiago; Chinellato, Alejandro; Dellamea, Guillermo; Ahualli, Alejandro; Rompato, Silvana; Velez, Julio; Escobar, Rafael; Zwenger, Ariel; Rosales, Cristina; Bagnes, Claudia; Puyol, Jorge; Niewiadomski, Dario; Smecuol, Edgardo; Nachman, Fabio; Gonzalez, Eduardo; Ferraris, Gustavo; Suppicich, Juan Ramos; Price, Paola; Medina, Luis; O’Connor, Juan title: Multidisciplinary approach to COVID-19 and cancer: consensus from scientific societies in Argentina date: 2020-05-13 journal: Ecancermedicalscience DOI: 10.3332/ecancer.2020.1044 sha: doc_id: 342303 cord_uid: ddulfe06 file: cache/cord-342068-zhk3wmou.json key: cord-342068-zhk3wmou authors: Khazanie, Prateeti; Wynia, Matthew K.; Dickert, Neal W. title: Forced Choices: Ethical Challenges in Cardiology During the COVID-19 Pandemic date: 2020-05-11 journal: Circulation DOI: 10.1161/circulationaha.120.047681 sha: doc_id: 342068 cord_uid: zhk3wmou file: cache/cord-341933-dwki1hwu.json key: cord-341933-dwki1hwu authors: Jeong, Han-Gil; Lee, Yunghee; Song, Kyoung-Ho; Hwang, In-Chang; Kim, Eu Suk; Cho, Young-Jae title: Therapeutic Temperature Modulation for a Critically Ill Patient with COVID-19 date: 2020-06-03 journal: J Korean Med Sci DOI: 10.3346/jkms.2020.35.e210 sha: doc_id: 341933 cord_uid: dwki1hwu file: cache/cord-340984-blkhfhe2.json key: cord-340984-blkhfhe2 authors: Gklinos, Panagiotis title: Neurological manifestations of COVID-19: a review of what we know so far date: 2020-05-26 journal: J Neurol DOI: 10.1007/s00415-020-09939-5 sha: doc_id: 340984 cord_uid: blkhfhe2 file: cache/cord-342139-t2tukk0z.json key: cord-342139-t2tukk0z authors: Livingston, Gill; Rostamipour, Hossein; Gallagher, Paul; Kalafatis, Chris; Shastri, Abhishek; Huzzey, Lauren; Liu, Kathy; Sommerlad, Andrew; Marston, Louise title: Prevalence, management, and outcomes of SARS-CoV-2 infections in older people and those with dementia in mental health wards in London, UK: a retrospective observational study date: 2020-10-05 journal: Lancet Psychiatry DOI: 10.1016/s2215-0366(20)30434-x sha: doc_id: 342139 cord_uid: t2tukk0z file: cache/cord-342857-vj6sw2ne.json key: cord-342857-vj6sw2ne authors: McCullough, Peter A.; Kelly, Ronan J.; Ruocco, Gaetano; Lerma, Edgar; Tumlin, James; Wheelan, Kevin; Katz, Nevin; Lepor, Norman E.; Vijay, Kris; Carter, Harvey; Singh, Bhupinder; McCullough, Sean P.; Bhambi, Brijesh K.; Palazzuoli, Alberto; De Ferrari, Gaetano M; Milligan, Gregory; Safder, Taimur; Tecson, Kristen M.; Wang, Dee Dee; McKinnon; O'Neill, William W.; Zervos, Marcus; Risch, Harvey A. title: Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection date: 2020-08-07 journal: Am J Med DOI: 10.1016/j.amjmed.2020.07.003 sha: doc_id: 342857 cord_uid: vj6sw2ne file: cache/cord-343052-dc9s2rau.json key: cord-343052-dc9s2rau authors: Murgo, Salvatore; Lheureux, Olivier; Taccone, Fabio; Vouche, Michael; Golzarian, Jafar title: Haemoptysis treated by bronchial artery embolisation in severe acute respiratory syndrome coronavirus 2: case report date: 2020-09-05 journal: CVIR Endovasc DOI: 10.1186/s42155-020-00154-x sha: doc_id: 343052 cord_uid: dc9s2rau file: cache/cord-341284-jmqdnart.json key: cord-341284-jmqdnart authors: Panagopoulos, Periklis; Petrakis, Vasilis; Panopoulou, Maria; Trypsianis, Grigorios; Penlioglou, Theano; Pnevmatikos, Ioannis; Papazoglou, Dimitrios title: Lopinavir/ritonavir as a third agent in the antiviral regimen for SARS-CoV-2 infection date: 2020-06-12 journal: J Chemother DOI: 10.1080/1120009x.2020.1775424 sha: doc_id: 341284 cord_uid: jmqdnart file: cache/cord-343201-98scxky8.json key: cord-343201-98scxky8 authors: Thibault, Ronan; Coëffier, Moïse; Joly, Francisca; Bohé, Julien; Schneider, Stéphane M.; Déchelotte, Pierre title: How the Covid-19 epidemic is challenging our practice in clinical nutrition—feedback from the field date: 2020-09-16 journal: Eur J Clin Nutr DOI: 10.1038/s41430-020-00757-6 sha: doc_id: 343201 cord_uid: 98scxky8 file: cache/cord-342519-tjr6dvtt.json key: cord-342519-tjr6dvtt authors: Souza, Thiago Moreno L.; Salluh, Jorge I. F.; Bozza, Fernando A.; Mesquita, Milene; Soares, Márcio; Motta, Fernando C.; Pitrowsky, Melissa Tassano; de Lourdes Oliveira, Maria; Mishin, Vasiliy P.; Gubareva, Larissa V.; Whitney, Anne; Rocco, Sandra Amaral; Gonçalves, Vânia Maria C.; Marques, Venceslaine Prado; Velasco, Eduardo; Siqueira, Marilda M. title: H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis date: 2010-11-30 journal: PLoS One DOI: 10.1371/journal.pone.0014158 sha: doc_id: 342519 cord_uid: tjr6dvtt file: cache/cord-340857-teq5txm9.json key: cord-340857-teq5txm9 authors: Galloro, Giuseppe; Pisani, Antonio; Zagari, Rocco Maurizio; Lamazza, Antonietta; Cengia, Gianpaolo; Ciliberto, Enrico; Conigliaro, Rita L.; Carrara, Paola Da Massa; Germanà, Bastianello; Pasquale, Luigi title: SAFETY IN DIGESTIVE ENDOSCOPY PROCEDURES IN THE COVID ERA RECOMMENDATIONS IN PROGRES OF THE ITALIAN SOCIETY OF DIGESTIVE ENDOSCOPY date: 2020-05-13 journal: Dig Liver Dis DOI: 10.1016/j.dld.2020.05.002 sha: doc_id: 340857 cord_uid: teq5txm9 file: cache/cord-341234-2zgfcrwc.json key: cord-341234-2zgfcrwc authors: Hallak, Jorge; Esteves, Sandro C. title: Concise practice recommendations for the provision of andrological services and assisted reproductive technology for male infertility patients during the SARS-CoV-2 in Brazil date: 2020-09-02 journal: Int Braz J Urol DOI: 10.1590/s1677-5538.ibju.2020.06.03 sha: doc_id: 341234 cord_uid: 2zgfcrwc file: cache/cord-341314-1mav631s.json key: cord-341314-1mav631s authors: Caso, Valeria; Federico, Antonio title: No lockdown for neurological diseases during COVID19 pandemic infection date: 2020-04-08 journal: Neurol Sci DOI: 10.1007/s10072-020-04389-3 sha: doc_id: 341314 cord_uid: 1mav631s file: cache/cord-341999-nosdj7b2.json key: cord-341999-nosdj7b2 authors: Conti, A.; Lasagni, C.; Bigi, L.; Pellacani, G. title: Evolution of COVID‐19 infection in 4 psoriatic patients treated with biological drugs date: 2020-05-07 journal: J Eur Acad Dermatol Venereol DOI: 10.1111/jdv.16587 sha: doc_id: 341999 cord_uid: nosdj7b2 file: cache/cord-341076-ox2ckhqu.json key: cord-341076-ox2ckhqu authors: Cenzato, Marco; DiMeco, Francesco; Fontanella, Marco; Locatelli, Davide; Servadei, Franco title: Editorial. Neurosurgery in the storm of COVID-19: suggestions from the Lombardy region, Italy (ex malo bonum) date: 2020-04-10 journal: J Neurosurg DOI: 10.3171/2020.3.jns20960 sha: doc_id: 341076 cord_uid: ox2ckhqu file: cache/cord-342569-ja96xfns.json key: cord-342569-ja96xfns authors: Azer, Samy A. title: COVID-19: Pathophysiology, diagnosis, complications and Investigational therapeutics date: 2020-08-05 journal: New Microbes New Infect DOI: 10.1016/j.nmni.2020.100738 sha: doc_id: 342569 cord_uid: ja96xfns file: cache/cord-342808-yonbowkb.json key: cord-342808-yonbowkb authors: Francque, Sven title: Innovative liver research continues during the current pandemic date: 2020-05-24 journal: JHEP Rep DOI: 10.1016/j.jhepr.2020.100121 sha: doc_id: 342808 cord_uid: yonbowkb file: cache/cord-343308-5i31ysee.json key: cord-343308-5i31ysee authors: Liu, Juan; Xiao, Yong; Shen, Yuan; Shi, Chao; Chen, Yujun; Shi, Ping; Gao, Yumeng; Wang, Yiqing; Lu, Bin title: Detection of SARS‐CoV‐2 by RT‐PCR in anal from patients who have recovered from coronavirus disease 2019 date: 2020-04-14 journal: J Med Virol DOI: 10.1002/jmv.25875 sha: doc_id: 343308 cord_uid: 5i31ysee file: cache/cord-341359-c34gyuv6.json key: cord-341359-c34gyuv6 authors: Larson, Derek T; Sherner, John H; Gallagher, Kia M; Judy, Cynthia L; Paul, Madison B; Mahoney, Alexandra M; Weina, Peter J title: Clinical Outcomes of Coronavirus Disease 2019 With Evidence-based Supportive Care date: 2020-05-30 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa678 sha: doc_id: 341359 cord_uid: c34gyuv6 file: cache/cord-342841-b1rucgmg.json key: cord-342841-b1rucgmg authors: Di Carlo, Francesco; Sociali, Antonella; Picutti, Elena; Pettorruso, Mauro; Vellante, Federica; Verrastro, Valeria; Martinotti, Giovanni; di Giannantonio, Massimo title: Telepsychiatry and other cutting edge technologies in Covid‐19 pandemic: bridging the distance in mental health assistance date: 2020-09-18 journal: Int J Clin Pract DOI: 10.1111/ijcp.13716 sha: doc_id: 342841 cord_uid: b1rucgmg file: cache/cord-341670-o1v63zg8.json key: cord-341670-o1v63zg8 authors: Estevez-Ordonez, Dagoberto; Laskay, Nicholas M B; Chagoya, Gustavo; Alam, Yasaman; Atchley, Travis J; Elsayed, Galal A; Farr, George A; Totten, Arthur H; Leal, Sixto M; Fisher, Winfield S title: Letter: Perioperative and Critical Care Management of a Patient With Severe Acute Respiratory Syndrome Corona Virus 2 Infection and Aneurysmal Subarachnoid Hemorrhage date: 2020-05-20 journal: Neurosurgery DOI: 10.1093/neuros/nyaa197 sha: doc_id: 341670 cord_uid: o1v63zg8 file: cache/cord-342786-dl8vjwfn.json key: cord-342786-dl8vjwfn authors: Sattar, Yasar; Ullah, Waqas; Rauf, Hiba; ul Hassan Virk, Hafeez; Yadav, Sunita; Chowdhury, Medhat; Connerney, Michael; Mamtani, Sahil; Pahuja, Mohit; Patel, Raj D.; Mir, Tanveer; Almas, Talal; Moussa Pacha, Homam; Chadi Alraies, M title: COVID-19 Cardiovascular Epidemiology, Cellular Pathogenesis, Clinical Manifestations and Management date: 2020-07-14 journal: Int J Cardiol Heart Vasc DOI: 10.1016/j.ijcha.2020.100589 sha: doc_id: 342786 cord_uid: dl8vjwfn file: cache/cord-341919-8gnthufw.json key: cord-341919-8gnthufw authors: Basi, Saajan; Hamdan, Mohammad; Punekar, Shuja title: Clinical course of a 66-year-old man with an acute ischaemic stroke in the setting of a COVID-19 infection date: 2020-08-23 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-235920 sha: doc_id: 341919 cord_uid: 8gnthufw file: cache/cord-341591-ib8lsvku.json key: cord-341591-ib8lsvku authors: Simpson, J. Keith; Innes, Stanley title: Informed consent, duty of disclosure and chiropractic: where are we? date: 2020-11-04 journal: Chiropr Man Therap DOI: 10.1186/s12998-020-00342-5 sha: doc_id: 341591 cord_uid: ib8lsvku file: cache/cord-342809-wrxejwms.json key: cord-342809-wrxejwms authors: Song, Jungeun; Kweon, Yong-Sil; Hong, Sung Hee; Kim, Joonbeom; Chun, Ka Hye; Bahn, Geon Ho; Yook, Ki-Hwan; Shin, Dongwon; Hong, Hyun Ju title: Characteristics of First Visit Pediatric Patients with Suicidal Ideation and Behavior: An 8-Year Retrospective Chart Review date: 2020-10-01 journal: Soa Chongsonyon Chongsin Uihak DOI: 10.5765/jkacap.200029 sha: doc_id: 342809 cord_uid: wrxejwms file: cache/cord-343490-94vkfrtw.json key: cord-343490-94vkfrtw authors: Handaya, Adeodatus Yuda; Andrew, Joshua; Hanif, Ahmad Shafa; Fauzi, Aditya Rifqi title: Covid-19 mimicking symptoms in emergency gastrointestinal surgery cases during pandemic: a case series date: 2020-10-24 journal: Int J Surg Case Rep DOI: 10.1016/j.ijscr.2020.10.064 sha: doc_id: 343490 cord_uid: 94vkfrtw file: cache/cord-343743-6k3soh1l.json key: cord-343743-6k3soh1l authors: Chaudhary, Sachin; Natt, Bhupinder; Bime, Christian; Knox, Kenneth S.; Glassberg, Marilyn K. title: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused date: 2020-09-09 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00539 sha: doc_id: 343743 cord_uid: 6k3soh1l file: cache/cord-342979-pvewvmmf.json key: cord-342979-pvewvmmf authors: Martínez-del Río, Jorge; Piqueras-Flores, Jesús; Nieto-Sandoval Martín de la Sierra, Patricia; Negreira-Caamaño, Martín; Águila-Gordo, Daniel; Mateo-Gómez, Cristina; Salas-Bravo, Daniel; Rodríguez-Martínez, Marta title: Comparative analysis between the use of renin-angiotensin system antagonists and clinical outcomes of hospitalized patients with COVID-19 respiratory infection date: 2020-11-12 journal: Med Clin (Engl Ed) DOI: 10.1016/j.medcle.2020.07.013 sha: doc_id: 342979 cord_uid: pvewvmmf file: cache/cord-343393-8hdygwip.json key: cord-343393-8hdygwip authors: Kudsi, Omar Yusef; Chang, Karen; Bou‐Ayash, Naseem title: Robotic Low Anterior Resection for a Distal Sigmoid Colon Cancer during the COVID‐19 Pandemic – a Video Vignette date: 2020-08-13 journal: Colorectal Dis DOI: 10.1111/codi.15310 sha: doc_id: 343393 cord_uid: 8hdygwip file: cache/cord-343023-e1uv7t6p.json key: cord-343023-e1uv7t6p authors: Zhang, Jingchen; He, Xujian; Hu, Jia; Li, Tong title: Failure of early extubation among cases of coronavirus disease-19 respiratory failure: Case report and clinical experience date: 2020-07-02 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000020843 sha: doc_id: 343023 cord_uid: e1uv7t6p file: cache/cord-342451-yfy5jcw6.json key: cord-342451-yfy5jcw6 authors: Rigamonti, Andrea; Mantero, Vittorio; Piamarta, Francesca; Spena, Giannantonio; Salmaggi, Andrea title: Cerebral venous thrombosis associated with coronavirus infection: an underestimated entity? date: 2020-06-29 journal: Neurol Sci DOI: 10.1007/s10072-020-04539-7 sha: doc_id: 342451 cord_uid: yfy5jcw6 file: cache/cord-342930-f7cw2ca6.json key: cord-342930-f7cw2ca6 authors: Portincasa, Piero; Krawczyk, Marcin; Machill, Antonia; Lammert, Frank; Ciaula, Agostino Di title: Hepatic consequences of COVID-19 infection. Lapping or biting? date: 2020-06-01 journal: Eur J Intern Med DOI: 10.1016/j.ejim.2020.05.035 sha: doc_id: 342930 cord_uid: f7cw2ca6 file: cache/cord-343452-4m0ub9iv.json key: cord-343452-4m0ub9iv authors: Barkama, Ravit; Mayo, Ami; Paz, Alona; Solopov, Anna; Mann, Tal; Vadasz, Zahava; Appel, Tal; Ofir, Racheli; Shani, Liran; Sheleg, Michal; Allen, Hoshea; Shaked Nitzan, Rony; Tsarfaty, Nurit; Gilad, Hadar; Birch, Thomas; Kachel, Erez; Reinke, Petra; Volk, Hans-Dieter; Zalts, Ronen; Raz Pasteur, Ayelet title: Placenta-Derived Cell Therapy to Treat Patients With Respiratory Failure Due to Coronavirus Disease 2019 date: 2020-09-15 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000207 sha: doc_id: 343452 cord_uid: 4m0ub9iv file: cache/cord-342603-k0f33p3l.json key: cord-342603-k0f33p3l authors: Spyropoulos, Alex C.; Levy, Jerrold H.; Ageno, Walter; Connors, Jean Marie; Hunt, Beverley J; Iba, Toshiaki; Levi, Marcel; Samama, Charles Marc; Thachil, Jecko; Giannis, Dimitrios; Douketis, James D. title: Scientific and Standardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID‐19 date: 2020-05-27 journal: J Thromb Haemost DOI: 10.1111/jth.14929 sha: doc_id: 342603 cord_uid: k0f33p3l file: cache/cord-343715-y594iewi.json key: cord-343715-y594iewi authors: Gavriatopoulou, Maria; Korompoki, Eleni; Fotiou, Despina; Ntanasis-Stathopoulos, Ioannis; Psaltopoulou, Theodora; Kastritis, Efstathios; Terpos, Evangelos; Dimopoulos, Meletios A. title: Organ-specific manifestations of COVID-19 infection date: 2020-07-27 journal: Clin Exp Med DOI: 10.1007/s10238-020-00648-x sha: doc_id: 343715 cord_uid: y594iewi file: cache/cord-343819-1uki4b3d.json key: cord-343819-1uki4b3d authors: Mian, Muhammad S; Razaq, Laiba; Khan, Safeera; Hussain, Nadia; Razaq, Mahrukh title: Pathological Findings and Management of COVID-19 Patients: A Brief Overview of Modern-day Pandemic date: 2020-05-15 journal: Cureus DOI: 10.7759/cureus.8136 sha: doc_id: 343819 cord_uid: 1uki4b3d file: cache/cord-343973-n5ogyxz7.json key: cord-343973-n5ogyxz7 authors: Ip, Andrew; Berry, Donald A.; Hansen, Eric; Goy, Andre H.; Pecora, Andrew L.; Sinclaire, Brittany A.; Bednarz, Urszula; Marafelias, Michael; Berry, Scott M.; Berry, Nicholas S.; Mathura, Shivam; Sawczuk, Ihor S.; Biran, Noa; Go, Ronaldo C.; Sperber, Steven; Piwoz, Julia A.; Balani, Bindu; Cicogna, Cristina; Sebti, Rani; Zuckerman, Jerry; Rose, Keith M.; Tank, Lisa; Jacobs, Laurie G.; Korcak, Jason; Timmapuri, Sarah L.; Underwood, Joseph P.; Sugalski, Gregory; Barsky, Carol; Varga, Daniel W.; Asif, Arif; Landolfi, Joseph C.; Goldberg, Stuart L. title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 journal: PLoS One DOI: 10.1371/journal.pone.0237693 sha: doc_id: 343973 cord_uid: n5ogyxz7 file: cache/cord-343205-zjw4fbfd.json key: cord-343205-zjw4fbfd authors: Bhaskar, Sonu; Bradley, Sian; Chattu, Vijay Kumar; Adisesh, Anil; Nurtazina, Alma; Kyrykbayeva, Saltanat; Sakhamuri, Sateesh; Moguilner, Sebastian; Pandya, Shawna; Schroeder, Starr; Banach, Maciej; Ray, Daniel title: Telemedicine as the New Outpatient Clinic Gone Digital: Position Paper From the Pandemic Health System REsilience PROGRAM (REPROGRAM) International Consortium (Part 2) date: 2020-09-07 journal: Front Public Health DOI: 10.3389/fpubh.2020.00410 sha: doc_id: 343205 cord_uid: zjw4fbfd file: cache/cord-343437-cz1w9od9.json key: cord-343437-cz1w9od9 authors: Kahaly, George J title: Management of Graves‘Thyroidal And Extrathyroidal Disease – An Update date: 2020-09-14 journal: J Clin Endocrinol Metab DOI: 10.1210/clinem/dgaa646 sha: doc_id: 343437 cord_uid: cz1w9od9 file: cache/cord-343773-9f7ew8uj.json key: cord-343773-9f7ew8uj authors: Volo, T.; Stritoni, P.; Battel, I.; Zennaro, B.; Lazzari, F.; Bellin, M.; Michieletto, L.; Spinato, G.; Busatto, C.; Politi, D.; Spinato, R. title: Elective tracheostomy during COVID-19 outbreak: to whom, when, how? Early experience from Venice, Italy date: 2020-07-12 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06190-6 sha: doc_id: 343773 cord_uid: 9f7ew8uj file: cache/cord-343876-2inr4mcy.json key: cord-343876-2inr4mcy authors: Xie, Qin; Fan, Fang; Fan, Xue-Peng; Wang, Xiao-Jiang; Chen, Ming-Jian; Zhong, Bao-Liang; Chiu, Helen Fung-Kum title: COVID-19 patients managed in psychiatric inpatient settings due to first-episode mental disorders in Wuhan, China: clinical characteristics, treatments, outcomes, and our experiences date: 2020-10-02 journal: Transl Psychiatry DOI: 10.1038/s41398-020-01022-x sha: doc_id: 343876 cord_uid: 2inr4mcy file: cache/cord-343797-kpmz5kwg.json key: cord-343797-kpmz5kwg authors: Lee, Martin Beng‐Huat; Chua, Horng Ruey; Wong, Weng Kin; Chan, Gek Cher; Leo, Christopher Cheang Han; Vathsala, Anantharaman; Teo, Boon Wee title: GOING TO WAR ON COVID19: MOBILIZING AN ACADEMIC NEPHROLOGY GROUP PRACTICE date: 2020-07-04 journal: Nephrology (Carlton) DOI: 10.1111/nep.13753 sha: doc_id: 343797 cord_uid: kpmz5kwg file: cache/cord-343917-67qjqxqh.json key: cord-343917-67qjqxqh authors: Dabrowska, Dominika; Lock, Gareth John title: Staying Ahead of the Curve: Modified Approach to Emergency Caesarean Section Under General Anaesthesia in COVID-19 Pandemic date: 2020-04-30 journal: Turk J Anaesthesiol Reanim DOI: 10.5152/tjar.2020.280420 sha: doc_id: 343917 cord_uid: 67qjqxqh file: cache/cord-344004-z7pn7u6u.json key: cord-344004-z7pn7u6u authors: Shaha, Ashok R. title: Thyroid surgery during COVID‐19 pandemic: Principles and philosophies date: 2020-04-27 journal: Head Neck DOI: 10.1002/hed.26198 sha: doc_id: 344004 cord_uid: z7pn7u6u file: cache/cord-343877-jzkaee16.json key: cord-343877-jzkaee16 authors: Newdick, Chris; Sheehan, Mark; Dunn, Michael title: Tragic choices in intensive care during the COVID-19 pandemic: on fairness, consistency and community date: 2020-08-07 journal: J Med Ethics DOI: 10.1136/medethics-2020-106487 sha: doc_id: 343877 cord_uid: jzkaee16 file: cache/cord-343443-ljehete1.json key: cord-343443-ljehete1 authors: Kissling, Sébastien; Rotman, Samuel; Gerber, Christel; Halfon, Matthieu; Lamoth, Frédéric; Comte, Denis; Lhopitallier, Loïc; Sadallah, Salima; Fakhouri, Fadi title: Collapsing glomerulopathy in a COVID-19 patient. date: 2020-04-15 journal: Kidney Int DOI: 10.1016/j.kint.2020.04.006 sha: doc_id: 343443 cord_uid: ljehete1 file: cache/cord-344185-jz6ui4w3.json key: cord-344185-jz6ui4w3 authors: Aziz, Aleha; Ona, Samsiya; Martinez, Rebecca H.; Ring, Laurence E.; Baptiste, Caitlin; Syeda, Sbaa; Sheen, Jean- Ju; Gyamfi-Bannerman, Cynthia; D'Alton, Mary E.; Goffman, Dena; Landau, Ruth; Valderrama, Natali E.; Moroz, Leslie title: Building an Obstetric Intensive Care Unit during the COVID-19 Pandemic at a Tertiary Hospital and Selected Maternal-Fetal and Delivery Considerations date: 2020-07-24 journal: Semin Perinatol DOI: 10.1016/j.semperi.2020.151298 sha: doc_id: 344185 cord_uid: jz6ui4w3 file: cache/cord-344117-lr6roxej.json key: cord-344117-lr6roxej authors: Vieira, Ana Luisa Silveira; Pazeli Júnior, José Muniz; Bastos, Marcus Gomes title: Role of point-of-care ultrasound during the COVID-19 pandemic: our recommendations in the management of dialytic patients date: 2020-06-03 journal: Ultrasound J DOI: 10.1186/s13089-020-00177-4 sha: doc_id: 344117 cord_uid: lr6roxej file: cache/cord-344135-pyibu6rj.json key: cord-344135-pyibu6rj authors: Zuo, Peiyuan; Tong, Song; Yan, Qi; Cheng, Ling; Li, Yuanyuan; Song, Kaixin; Chen, Yuting; Dai, Yue; Gao, Hongyu; Zhang, Cuntai title: Decreased prealbumin level is associated with increased risk of mortality in hospitalized elderly patients with COVID-19 date: 2020-07-03 journal: Nutrition DOI: 10.1016/j.nut.2020.110930 sha: doc_id: 344135 cord_uid: pyibu6rj file: cache/cord-343897-f4imrltt.json key: cord-343897-f4imrltt authors: Weimer, Louis H. title: Neuromuscular disorders in pregnancy date: 2020-08-04 journal: Handb Clin Neurol DOI: 10.1016/b978-0-444-64240-0.00012-x sha: doc_id: 343897 cord_uid: f4imrltt file: cache/cord-344104-592r71l1.json key: cord-344104-592r71l1 authors: Ardati, Amer K.; Mena Lora, Alfredo J. title: Be Prepared date: 2020-03-17 journal: Circ Cardiovasc Qual Outcomes DOI: 10.1161/circoutcomes.120.006661 sha: doc_id: 344104 cord_uid: 592r71l1 file: cache/cord-343970-anocx4y1.json key: cord-343970-anocx4y1 authors: Bansal, Rashika; Gubbi, Sriram; Muniyappa, Ranganath title: Metabolic Syndrome and COVID 19: Endocrine-Immune-Vascular Interactions Shapes Clinical Course date: 2020-06-30 journal: Endocrinology DOI: 10.1210/endocr/bqaa112 sha: doc_id: 343970 cord_uid: anocx4y1 file: cache/cord-344270-874i31h8.json key: cord-344270-874i31h8 authors: Radke, Robert M; Frenzel, Tim; Baumgartner, Helmut; Diller, Gerhard-Paul title: Adult congenital heart disease and the COVID-19 pandemic date: 2020-06-10 journal: Heart DOI: 10.1136/heartjnl-2020-317258 sha: doc_id: 344270 cord_uid: 874i31h8 file: cache/cord-343566-epvswt7f.json key: cord-343566-epvswt7f authors: Wang, Zhao-Hua; Shu, Chang; Ran, Xiao; Xie, Cui-Hong; Zhang, Lei title: Critically Ill Patients with Coronavirus Disease 2019 in a Designated ICU: Clinical Features and Predictors for Mortality date: 2020-07-20 journal: Risk Manag Healthc Policy DOI: 10.2147/rmhp.s263095 sha: doc_id: 343566 cord_uid: epvswt7f file: cache/cord-343832-xg3swuzs.json key: cord-343832-xg3swuzs authors: Pugliese, Daniela; Papi, Claudio; Privitera, Giuseppe; Aratari, Annalisa; Festa, Stefano; Armuzzi, Alessandro title: The management of Inflammatory Bowel Diseases in the era of COVID-19 pandemic: when “non-urgent” does not mean “deferrable” date: 2020-06-18 journal: Dig Liver Dis DOI: 10.1016/j.dld.2020.05.053 sha: doc_id: 343832 cord_uid: xg3swuzs file: cache/cord-344271-5aynmdsk.json key: cord-344271-5aynmdsk authors: de Souza Luna, Luciano Kleber; Panning, Marcus; Grywna, Klaus; Pfefferle, Susanne; Drosten, Christian title: Spectrum of Viruses and Atypical Bacteria in Intercontinental Air Travelers with Symptoms of Acute Respiratory Infection date: 2007-03-01 journal: J Infect Dis DOI: 10.1086/511432 sha: doc_id: 344271 cord_uid: 5aynmdsk file: cache/cord-344389-aj9q73f0.json key: cord-344389-aj9q73f0 authors: Brosnahan, Shari B.; Bhatt, Alok; Berger, Jeffery S.; Yuriditsky, Eugene; Iturrate, Eduardo; Amoroso, Nancy E. title: COVID-19 Pneumonia Hospitalizations Followed by Re-presentation for Presumed Thrombotic Event date: 2020-06-23 journal: Chest DOI: 10.1016/j.chest.2020.06.023 sha: doc_id: 344389 cord_uid: aj9q73f0 file: cache/cord-344120-7t5ce2hb.json key: cord-344120-7t5ce2hb authors: Baroutjian, Amanda; Sanchez, Carol; Boneva, Dessy; McKenney, Mark; Elkbuli, Adel title: SARS-CoV-2 pharmacologic therapies and their safety/effectiveness according to level of evidence date: 2020-09-01 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.08.091 sha: doc_id: 344120 cord_uid: 7t5ce2hb file: cache/cord-344131-e7phs0jd.json key: cord-344131-e7phs0jd authors: Ford, Richard B.; Mazzaferro, Elisa M. title: Section 4 Diagnostic and Therapeutic Procedures date: 2012-12-31 journal: Kirk & Bistner's Handbook of Veterinary Procedures and Emergency Treatment DOI: 10.1016/b978-1-4377-0798-4.00004-9 sha: doc_id: 344131 cord_uid: e7phs0jd file: cache/cord-344191-veug3dae.json key: cord-344191-veug3dae authors: Weiling, Lydia Li; Ming Kai, Alton Chew; Gunasekeran, Dinesh Visva title: Digital health for patients with chronic pain during the COVID-19 pandemic date: 2020-08-10 journal: Br J Anaesth DOI: 10.1016/j.bja.2020.08.003 sha: doc_id: 344191 cord_uid: veug3dae file: cache/cord-344017-qldawc8m.json key: cord-344017-qldawc8m authors: Edouard, S.; Colson, P.; Melenotte, C.; Di Pinto, F.; Thomas, L.; La Scola, B.; Million, M.; Tissot-Dupont, H.; Gautret, P.; Stein, A.; Brouqui, P.; Parola, P.; Lagier, J.-C.; Raoult, D.; Drancourt, Michel title: Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France date: 2020-11-11 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-020-04104-2 sha: doc_id: 344017 cord_uid: qldawc8m file: cache/cord-341063-3rqnu5bu.json key: cord-341063-3rqnu5bu authors: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 journal: Crit Care DOI: 10.1186/s13054-018-1973-5 sha: doc_id: 341063 cord_uid: 3rqnu5bu file: cache/cord-344302-p0v6sl9x.json key: cord-344302-p0v6sl9x authors: Gubitosa, James C; Xu, Phoenix; Ahmed, Ahmed; Pergament, Kathleen title: COVID-19-Associated Acute Limb Ischemia in a Patient on Therapeutic Anticoagulation date: 2020-09-25 journal: Cureus DOI: 10.7759/cureus.10655 sha: doc_id: 344302 cord_uid: p0v6sl9x file: cache/cord-344668-9m1vnpmo.json key: cord-344668-9m1vnpmo authors: Nitkunan, Arani; Paviour, Dominic; Nitkunan, Tharani title: COVID-19: switching to remote neurology outpatient consultations date: 2020-05-04 journal: Pract Neurol DOI: 10.1136/practneurol-2020-002571 sha: doc_id: 344668 cord_uid: 9m1vnpmo file: cache/cord-344508-a67vsux2.json key: cord-344508-a67vsux2 authors: Campanile, Fabio Cesare; Podda, Mauro; Arezzo, Alberto; Botteri, Emanuele; Sartori, Alberto; Guerrieri, Mario; Cassinotti, Elisa; Muttillo, Irnerio; Pisano, Marcello; Brachet Contul, Riccardo; D’Ambrosio, Giancarlo; Cuccurullo, Diego; Bergamini, Carlo; Allaix, Marco Ettore; Caracino, Valerio; Petz, Wanda Luisa; Milone, Marco; Silecchia, Gianfranco; Anania, Gabriele; Agrusa, Antonino; Di Saverio, Salomone; Casarano, Salvatore; Cicala, Caterina; Narilli, Piero; Federici, Sara; Carlini, Massimo; Paganini, Alessandro; Bianchi, Paolo Pietro; Salaj, Adelona; Mazzari, Andrea; Meniconi, Roberto Luca; Puzziello, Alessandro; Terrosu, Giovanni; De Simone, Belinda; Coccolini, Federico; Catena, Fausto; Agresta, Ferdinando title: Acute cholecystitis during COVID-19 pandemic: a multisocietary position statement date: 2020-06-08 journal: World J Emerg Surg DOI: 10.1186/s13017-020-00317-0 sha: doc_id: 344508 cord_uid: a67vsux2 file: cache/cord-344431-2wq7msqz.json key: cord-344431-2wq7msqz authors: Holzinger, Felix; Oslislo, Sarah; Möckel, Martin; Schenk, Liane; Pigorsch, Mareen; Heintze, Christoph title: Self-referred walk-in patients in the emergency department – who and why? Consultation determinants in a multicenter study of respiratory patients in Berlin, Germany date: 2020-09-10 journal: BMC Health Serv Res DOI: 10.1186/s12913-020-05689-2 sha: doc_id: 344431 cord_uid: 2wq7msqz file: cache/cord-344486-iu5flbcl.json key: cord-344486-iu5flbcl authors: Chiotos, Kathleen; Hayes, Molly; Kimberlin, David W; Jones, Sarah B; James, Scott H; Pinninti, Swetha G; Yarbrough, April; Abzug, Mark J; MacBrayne, Christine E; Soma, Vijaya L; Dulek, Daniel E; Vora, Surabhi B; Waghmare, Alpana; Wolf, Joshua; Olivero, Rosemary; Grapentine, Steven; Wattier, Rachel L; Bio, Laura; Cross, Shane J; Dillman, Nicholas O; Downes, Kevin J; Oliveira, Carlos R; Timberlake, Kathryn; Young, Jennifer; Orscheln, Rachel C; Tamma, Pranita D; Schwenk, Hayden T; Zachariah, Philip; Aldrich, Margaret L; Goldman, David L; Groves, Helen E; Rajapakse, Nipunie S; Lamb, Gabriella S; Tribble, Alison C; Hersh, Adam L; Thorell, Emily A; Denison, Mark R; Ratner, Adam J; Newland, Jason G; Nakamura, Mari M title: Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2 date: 2020-09-12 journal: J Pediatric Infect Dis Soc DOI: 10.1093/jpids/piaa115 sha: doc_id: 344486 cord_uid: iu5flbcl file: cache/cord-344765-agt60ksx.json key: cord-344765-agt60ksx authors: Bhogal, R.H.; Patel, P.H.; Doran, S.L.F.; Zar, S.; Pollok, J.M.; Jiao, L.R.; Allum, W.H.; Chaudry, M.A.; Kumar, S. title: Approach to upper GastroIntestinal cancer surgery during the COVID-19 pandemic – Experience from a UK cancer centre date: 2020-05-30 journal: Eur J Surg Oncol DOI: 10.1016/j.ejso.2020.05.022 sha: doc_id: 344765 cord_uid: agt60ksx file: cache/cord-345028-56hg62be.json key: cord-345028-56hg62be authors: Flinspach, Armin Niklas; Zacharowski, Kai; Ioanna, Deligiannis; Adam, Elisabeth Hannah title: Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients—A Case Series and Systematic Review date: 2020-10-21 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000256 sha: doc_id: 345028 cord_uid: 56hg62be file: cache/cord-344709-5hy1e4t1.json key: cord-344709-5hy1e4t1 authors: Patel, Brijesh V.; Arachchillage, Deepa J.; Ridge, Carole A.; Bianchi, Paolo; Doyle, James F.; Garfield, Benjamin; Ledot, Stephane; Morgan, Cliff; Passariello, Maurizio; Price, Susanna; Singh, Suveer; Thakuria, Louit; Trenfield, Sarah; Trimlett, Richard; Weaver, Christine; Wort, S. John; Xu, Tina; Padley, Simon P. G.; Devaraj, Anand title: Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations date: 2020-09-01 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202004-1412oc sha: doc_id: 344709 cord_uid: 5hy1e4t1 file: cache/cord-345381-9cckppk2.json key: cord-345381-9cckppk2 authors: Klimek, Ludger; Pfaar, Oliver; Worm, Margitta; Eiwegger, Thomas; Hagemann, Jan; Ollert, Markus; Untersmayr, Eva; Hoffmann-Sommergruber, Karin; Vultaggio, Alessandra; Agache, Ioana; Bavbek, Sevim; Bossios, Apostolos; Casper, Ingrid; Chan, Susan; Chatzipetrou, Alexia; Vogelberg, Christian; Firinu, Davide; Kauppi, Paula; Kolios, Antonios; Kothari, Akash; Matucci, Andrea; Palomares, Oscar; Szépfalusi, Zsolt; Pohl, Wolfgang; Hötzenecker, Wolfram; Rosenkranz, Alexander R.; Bergmann, Karl-Christian; Bieber, Thomas; Buhl, Roland; Buters, Jeroen; Darsow, Ulf; Keil, Thomas; Kleine-Tebbe, Jörg; Lau, Susanne; Maurer, Marcus; Merk, Hans; Mösges, Ralph; Saloga, Joachim; Staubach, Petra; Jappe, Uta; Rabe, Klaus F.; Rabe, Uta; Vogelmeier, Claus; Biedermann, Tilo; Jung, Kirsten; Schlenter, Wolfgang; Ring, Johannes; Chaker, Adam; Wehrmann, Wolfgang; Becker, Sven; Freudelsperger, Laura; Mülleneisen, Norbert; Nemat, Katja; Czech, Wolfgang; Wrede, Holger; Brehler, Randolf; Fuchs, Thomas; Tomazic, Peter-Valentin; Aberer, Werner; Fink-Wagner, Antje-Henriette; Horak, Fritz; Wöhrl, Stefan; Niederberger-Leppin, Verena; Pali-Schöll, Isabella; Pohl, Wolfgang; Roller-Wirnsberger, Regina; Spranger, Otto; Valenta, Rudolf; Akdis, Mübecell; Matricardi, Paolo M.; Spertini, François; Khaltaev, Nicolai; Michel, Jean-Pierre; Nicod, Larent; Schmid-Grendelmeier, Peter; Idzko, Marco; Hamelmann, Eckard; Jakob, Thilo; Werfel, Thomas; Wagenmann, Martin; Taube, Christian; Jensen-Jarolim, Erika; Korn, Stephanie; Hentges, Francois; Schwarze, Jürgen; O´Mahony, Liam; Knol, Edward F.; del Giacco, Stefano; Chivato Pérez, Tomás; Bousquet, Jean; Bedbrook, Anna; Zuberbier, Torsten; Akdis, Cezmi; Jutel, Marek title: Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)(A), Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)(B), Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)(C), Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)(D), Luxemburgische Gesellschaft für Allergologie und Immunologie (LGAI)(E), Österreichische Gesellschaft für Pneumologie (ÖGP)(F) in co-operation with the German, Austrian, and Swiss ARIA groups(G), and the European Academy of Allergy and Clinical Immunology (EAACI)(H) date: 2020-09-07 journal: Allergol Select DOI: 10.5414/alx02166e sha: doc_id: 345381 cord_uid: 9cckppk2 file: cache/cord-344939-rgxqobfw.json key: cord-344939-rgxqobfw authors: Ng, C. W. Q.; Tseng, M.; Lim, J. S. J.; Chan, C. W. title: Maintaining breast cancer care in the face of COVID‐19 date: 2020-08-24 journal: Br J Surg DOI: 10.1002/bjs.11835 sha: doc_id: 344939 cord_uid: rgxqobfw file: cache/cord-345445-9t1vebey.json key: cord-345445-9t1vebey authors: Radmanesh, Alireza; Derman, Anna; Lui, Yvonne W.; Raz, Eytan; Loh, John P.; Hagiwara, Mari; Borja, Maria J.; Zan, Elcin; Fatterpekar, Girish M. title: COVID-19–associated Diffuse Leukoencephalopathy and Microhemorrhages date: 2020-05-21 journal: Radiology DOI: 10.1148/radiol.2020202040 sha: doc_id: 345445 cord_uid: 9t1vebey file: cache/cord-344729-sjjedgws.json key: cord-344729-sjjedgws authors: Bhaskar, Sonu; Sharma, Divyansh; Walker, Antony H.; McDonald, Mark; Huasen, Bella; Haridas, Abilash; Mahata, Manoj Kumar; Jabbour, Pascal title: Acute Neurological Care in the COVID-19 Era: The Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium Pathway date: 2020-05-29 journal: Front Neurol DOI: 10.3389/fneur.2020.00579 sha: doc_id: 344729 cord_uid: sjjedgws file: cache/cord-344693-znw3dru4.json key: cord-344693-znw3dru4 authors: Lima, Brian; Gibson, Gregory T.; Vullaganti, Sirish; Malhame, Kathryn; Maybaum, Simon; Hussain, Syed T.; Shah, Samit; Majure, David T.; Wallach, Fran; Jang, Kristine; Bijol, Vanesa; Esposito, Michael J.; Williamson, Alex K.; Thomas, Rebecca M.; Bhuiya, Tawfiqul A.; Fernandez, Harold A.; Stevens, Gerin R. title: COVID‐19 in recent heart transplant recipients: Clinicopathologic features and early outcomes date: 2020-07-08 journal: Transpl Infect Dis DOI: 10.1111/tid.13382 sha: doc_id: 344693 cord_uid: znw3dru4 file: cache/cord-344853-s2p2csrx.json key: cord-344853-s2p2csrx authors: Hendren, Nicholas S.; Drazner, Mark H.; Bozkurt, Biykem; Cooper, Leslie T. title: Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome date: 2020-04-16 journal: Circulation DOI: 10.1161/circulationaha.120.047349 sha: doc_id: 344853 cord_uid: s2p2csrx file: cache/cord-345296-4z7yfj5s.json key: cord-345296-4z7yfj5s authors: Ho, Mei-Shang; Chen, Wei-Ju; Chen, Hour-Young; Lin, Szu-Fong; Wang, Min-Chin; Di, Jiali; Lu, Yen-Ta; Liu, Ching-Lung; Chang, Shan-Chwen; Chao, Chung-Liang; King, Chwan-Chuen; Chiou, Jeng-Min; Su, Ih-Jen; Yang, Jyh-Yuan title: Neutralizing Antibody Response and SARS Severity date: 2005-11-17 journal: Emerg Infect Dis DOI: 10.3201/eid1111.040659 sha: doc_id: 345296 cord_uid: 4z7yfj5s file: cache/cord-345628-a4c46m2w.json key: cord-345628-a4c46m2w authors: Unudurthi, Sathya D.; Luthra, Priya; Bose, Rajendran J.C.; McCarthy, Jason; Kontaridis, Maria Irene title: Cardiac inflammation in COVID-19: Lessons from heart failure date: 2020-09-21 journal: Life Sci DOI: 10.1016/j.lfs.2020.118482 sha: doc_id: 345628 cord_uid: a4c46m2w file: cache/cord-345517-ji4cet51.json key: cord-345517-ji4cet51 authors: Duarte de Araújo, António Manuel Silva; Correia-de-Sousa, António Jaime Botelho title: Copd: will there be room for nebulisers after the current covid-19 pandemic? date: 2020-09-16 journal: nan DOI: 10.1016/j.opresp.2020.08.001 sha: doc_id: 345517 cord_uid: ji4cet51 file: cache/cord-345632-iha2c5zo.json key: cord-345632-iha2c5zo authors: Hamdy, Sherif M; Abdel-Naseer, Maged; Shehata, Hatem S; Shalaby, Nevin M; Hassan, Amr; Elmazny, Alaa; Shaker, Ehab; Nada, Mona A F; Ahmed, Sandra M; Hegazy, Mohamed I; Mourad, Husam S; Abdelalim, Ahmed; Magdy, Rehab; Othman, Alshimaa S; Mekkawy, Doaa A; Kishk, Nirmeen A title: Management Strategies of Patients with Neuromyelitis Optica Spectrum Disorder During the COVID-19 Pandemic Era date: 2020-08-17 journal: Ther Clin Risk Manag DOI: 10.2147/tcrm.s261753 sha: doc_id: 345632 cord_uid: iha2c5zo file: cache/cord-344967-t88pedeb.json key: cord-344967-t88pedeb authors: Tang, Hon Lok; Cheuk, Au; Chu, Kwok Hong; Lee, William; Wong, Sze Ho; Cheng, Yuk Lun; Yu, Alex Wai Yin; Fung, Ka Shun; Tsang, Wai Kay; Chan, Hilda Wai Han; Tong, Kwok Lung title: Severe acute respiratory syndrome in haemodialysis patients: a report of two cases date: 2003-10-17 journal: Nephrol Dial Transplant DOI: 10.1093/ndt/gfg454 sha: doc_id: 344967 cord_uid: t88pedeb file: cache/cord-345611-xv62h83a.json key: cord-345611-xv62h83a authors: Cavalcanti, A. B.; Zampieri, F. G.; Azevedo, L. C.; Rosa, R. G.; Avezum, A.; Veiga, V. C.; Lopes, R. D.; Kawano-Dourado, L.; Damiani, L. P.; Pereira, A. J.; Serpa Neto, A.; Furtado, R.; Tomazini, B.; Bozza, F. A.; Maia, I. S.; Falavigna, M.; Lisboa, T. C.; Fonseca, H.; Machado, F. R.; Berwanger, O.; Investigators, COALITION COVID-19 Brazil I title: Hydroxychloroquine alone or in combination with azithromycin to prevent major clinical events in hospitalised patients with coronavirus infection (COVID-19): rationale and design of a randomised, controlled clinical trial date: 2020-05-26 journal: nan DOI: 10.1101/2020.05.19.20106997 sha: doc_id: 345611 cord_uid: xv62h83a file: cache/cord-345779-frspku51.json key: cord-345779-frspku51 authors: Pinto, Antonio; Giurazza, Francesco; Califano, Teresa; Rea, Gaetano; Valente, Tullio; Niola, Raffaella; Caranci, Ferdinando title: Interventional radiology in gynaecology and obstetric practice: safety issues date: 2020-09-30 journal: Semin Ultrasound CT MR DOI: 10.1053/j.sult.2020.09.004 sha: doc_id: 345779 cord_uid: frspku51 file: cache/cord-345655-fb4vv4my.json key: cord-345655-fb4vv4my authors: Islam, M. Z.; Riaz, B. K.; Islam, A. N. M. S.; Khanam, F.; Akhter, J.; Choudhury, R.; Farhana, N.; Jahan, N. A.; Uddin, M. J.; Efa, S. S. title: Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28th day of the disease course: a retrospective cohort study in Bangladesh date: 2020-10-29 journal: Epidemiology and infection DOI: 10.1017/s0950268820002630 sha: doc_id: 345655 cord_uid: fb4vv4my file: cache/cord-345680-10phij1x.json key: cord-345680-10phij1x authors: Terpos, Evangelos; Ntanasis‐Stathopoulos, Ioannis; Elalamy, Ismail; Kastritis, Efstathios; Sergentanis, Theodoros N.; Politou, Marianna; Psaltopoulou, Theodora; Gerotziafas, Grigoris; Dimopoulos, Meletios A. title: Hematological findings and complications of COVID‐19 date: 2020-05-23 journal: Am J Hematol DOI: 10.1002/ajh.25829 sha: doc_id: 345680 cord_uid: 10phij1x file: cache/cord-345860-d02x3151.json key: cord-345860-d02x3151 authors: Thome, Johannes; Coogan, Andrew N.; Simon, Frederick; Fischer, Matthias; Tucha, Oliver; Faltraco, Frank; Marazziti, Donatella; Butzer, Hermann title: The impact of the COVID-19 outbreak on the medico-legal and human rights of psychiatric patients date: 2020-05-29 journal: Eur Psychiatry DOI: 10.1192/j.eurpsy.2020.58 sha: doc_id: 345860 cord_uid: d02x3151 file: cache/cord-345371-pjbviagq.json key: cord-345371-pjbviagq authors: Lisi, Lucia; Lacal, Pedro Miguel; Barbaccia, Maria Luisa; Graziani, Grazia title: Approaching Coronavirus Disease 2019: mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2 date: 2020-07-23 journal: Biochem Pharmacol DOI: 10.1016/j.bcp.2020.114169 sha: doc_id: 345371 cord_uid: pjbviagq file: cache/cord-345762-khvcoqti.json key: cord-345762-khvcoqti authors: Scott, Ian A. title: COVID‐19 pandemic and the tension between the need to act and the need to know date: 2020-08-06 journal: Intern Med J DOI: 10.1111/imj.14929 sha: doc_id: 345762 cord_uid: khvcoqti file: cache/cord-345044-2fez1gu0.json key: cord-345044-2fez1gu0 authors: Proenca‐Modena, José Luiz; de Souza Cardoso, Ricardo; Criado, Miriã Ferreira; Milanez, Guilherme Paier; de Souza, William Marciel; Parise, Pierina Lorencini; Bertol, Jéssica Wildgrube; de Jesus, Bruna Lais Santos; Prates, Mirela Cristina Moreira; Silva, Maria Lúcia; Buzatto, Guilherme Pietrucci; Demarco, Ricardo Cassiano; Valera, Fabiana Cardoso Pereira; Tamashiro, Edwin; Anselmo‐Lima, Wilma Terezinha; Arruda, Eurico title: Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children date: 2019-03-18 journal: J Med Virol DOI: 10.1002/jmv.25441 sha: doc_id: 345044 cord_uid: 2fez1gu0 file: cache/cord-345092-1ztfcpsb.json key: cord-345092-1ztfcpsb authors: Iwasaki, Masae; Saito, Junichi; Zhao, Hailin; Sakamoto, Atsuhiro; Hirota, Kazuyoshi; Ma, Daqing title: Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications date: 2020-10-08 journal: Inflammation DOI: 10.1007/s10753-020-01337-3 sha: doc_id: 345092 cord_uid: 1ztfcpsb file: cache/cord-346061-pbghgitg.json key: cord-346061-pbghgitg authors: Passanisi, Stefano; Pecoraro, Maria; Pira, Francesco; Alibrandi, Angela; Donia, Vittoria; Lonia, Paola; Pajno, Giovanni Battista; Salzano, Giuseppina; Lombardo, Fortunato title: Quarantine Due to the COVID-19 Pandemic From the Perspective of Pediatric Patients With Type 1 Diabetes: A Web-Based Survey date: 2020-07-31 journal: Front Pediatr DOI: 10.3389/fped.2020.00491 sha: doc_id: 346061 cord_uid: pbghgitg file: cache/cord-345727-bcxkycjh.json key: cord-345727-bcxkycjh authors: Karimata, Yosuke; Kinjo, Takeshi; Parrott, Gretchen; Uehara, Ayako; Nabeya, Daijiro; Haranaga, Shusaku; Higa, Futoshi; Tateyama, Masao; Miyagawa, Keiko; Kishaba, Tomoo; Otani, Kanako; Okamoto, Michiko; Nishimura, Hidekazu; Fujita, Jiro title: Clinical Features of Human Metapneumovirus Pneumonia in Non-Immunocompromised Patients: An Investigation of Three Long-Term Care Facility Outbreaks date: 2018-09-15 journal: J Infect Dis DOI: 10.1093/infdis/jiy261 sha: doc_id: 345727 cord_uid: bcxkycjh file: cache/cord-346062-q0trgj12.json key: cord-346062-q0trgj12 authors: Robert, René; Kentish-Barnes, Nancy; Boyer, Alexandre; Laurent, Alexandra; Azoulay, Elie; Reignier, Jean title: Ethical dilemmas due to the Covid-19 pandemic date: 2020-06-17 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00702-7 sha: doc_id: 346062 cord_uid: q0trgj12 file: cache/cord-346241-w076l97s.json key: cord-346241-w076l97s authors: Zhang, Hua; Liu, Xiaohong; Yu, Peng; Cheng, Mingyuan; Wang, Weiting; Sun, Yipeng; Zeng, Bingliang; Fan, Bing title: Dynamic CT assessment of disease change and prognosis of patients with moderate COVID-19 pneumonia date: 2020-09-19 journal: Journal of X-ray science and technology DOI: 10.3233/xst-200711 sha: doc_id: 346241 cord_uid: w076l97s file: cache/cord-346288-9to4sdfq.json key: cord-346288-9to4sdfq authors: Haimovich, A.; Ravindra, N. G.; Stoytchev, S.; Young, H. P.; Wilson, F. P.; van Dijk, D.; Schulz, W. L.; Taylor, R. A. title: Development and validation of the COVID-19 severity index (CSI): a prognostic tool for early respiratory decompensation date: 2020-05-12 journal: nan DOI: 10.1101/2020.05.07.20094573 sha: doc_id: 346288 cord_uid: 9to4sdfq file: cache/cord-346276-1dcp05rd.json key: cord-346276-1dcp05rd authors: Bonfá, Eloisa; Gossec, Laure; Isenberg, David A.; Li, Zhanguo; Raychaudhuri, Soumya title: How COVID-19 is changing rheumatology clinical practice date: 2020-11-02 journal: Nat Rev Rheumatol DOI: 10.1038/s41584-020-00527-5 sha: doc_id: 346276 cord_uid: 1dcp05rd file: cache/cord-346607-1mewok8l.json key: cord-346607-1mewok8l authors: Oesterle, Tyler S.; Kolla, Bhanuprakash; Risma, Cameron J.; Breitinger, Scott A.; Rakocevic, Daniela B.; Loukianova, Larissa L.; Hall-Flavin, Daniel K.; Gentry, Melanie T.; Rummans, Teresa A.; Chauhan, Mohit; Gold, Mark S. title: Substance Use Disorders and Telehealth in the COVID-19 Pandemic Era: A New Outlook date: 2020-10-21 journal: Mayo Clin Proc DOI: 10.1016/j.mayocp.2020.10.011 sha: doc_id: 346607 cord_uid: 1mewok8l file: cache/cord-346345-jc9bq0zu.json key: cord-346345-jc9bq0zu authors: Smith, Colin M; Komisar, Jonathan R; Mourad, Ahmad; Kincaid, Brian R title: COVID-19-associated brief psychotic disorder date: 2020-08-11 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-236940 sha: doc_id: 346345 cord_uid: jc9bq0zu file: cache/cord-346987-fbqqf00i.json key: cord-346987-fbqqf00i authors: Guo, Yongwen; Jing, Yan; Wang, Yunshi; To, Aileen; Du, Shufang; Wang, Liuzheng; Bai, Ding title: Controls of SARS-CoV-2 transmission in orthodontic practice date: 2020-06-05 journal: Am J Orthod Dentofacial Orthop DOI: 10.1016/j.ajodo.2020.05.006 sha: doc_id: 346987 cord_uid: fbqqf00i file: cache/cord-347091-wbjpa5st.json key: cord-347091-wbjpa5st authors: Davis, Matthew R.; McCreary, Erin K.; Pogue, Jason M. title: That Escalated Quickly: Remdesivir's Place in Therapy for COVID-19 date: 2020-07-10 journal: Infect Dis Ther DOI: 10.1007/s40121-020-00318-1 sha: doc_id: 347091 cord_uid: wbjpa5st file: cache/cord-345546-v7t26oos.json key: cord-345546-v7t26oos authors: Wilenius, Lukas; Partinen, Markku title: Attention-Deficit/Hyperactivity Disorder Patients May Have Undiagnosed Narcolepsy date: 2020-06-04 journal: Cureus DOI: 10.7759/cureus.8436 sha: doc_id: 345546 cord_uid: v7t26oos file: cache/cord-346015-bzeqs5oh.json key: cord-346015-bzeqs5oh authors: Wang, Yeming; Zhang, Dingyu; Du, Guanhua; Du, Ronghui; Zhao, Jianping; Jin, Yang; Fu, Shouzhi; Gao, Ling; Cheng, Zhenshun; Lu, Qiaofa; Hu, Yi; Luo, Guangwei; Wang, Ke; Lu, Yang; Li, Huadong; Wang, Shuzhen; Ruan, Shunan; Yang, Chengqing; Mei, Chunlin; Wang, Yi; Ding, Dan; Wu, Feng; Tang, Xin; Ye, Xianzhi; Ye, Yingchun; Liu, Bing; Yang, Jie; Yin, Wen; Wang, Aili; Fan, Guohui; Zhou, Fei; Liu, Zhibo; Gu, Xiaoying; Xu, Jiuyang; Shang, Lianhan; Zhang, Yi; Cao, Lianjun; Guo, Tingting; Wan, Yan; Qin, Hong; Jiang, Yushen; Jaki, Thomas; Hayden, Frederick G; Horby, Peter W; Cao, Bin; Wang, Chen title: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial date: 2020-04-29 journal: Lancet DOI: 10.1016/s0140-6736(20)31022-9 sha: doc_id: 346015 cord_uid: bzeqs5oh file: cache/cord-346389-gbmnoo84.json key: cord-346389-gbmnoo84 authors: Callender, Lauren A.; Curran, Michelle; Bates, Stephanie M.; Mairesse, Maelle; Weigandt, Julia; Betts, Catherine J. title: The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19 date: 2020-08-11 journal: Front Immunol DOI: 10.3389/fimmu.2020.01991 sha: doc_id: 346389 cord_uid: gbmnoo84 file: cache/cord-346459-tkt5ldyo.json key: cord-346459-tkt5ldyo authors: Jie, Li Shao; Yu, Yuan; Ping, Zeng Jian; Dong, Xiang Xu; Ping, Chai Xiang; Chao, Hu; Li, Yang; Jing, Yang; Ling, Tan Yan; Yan, Jiang Ming; Peng, Ling title: Risk factors for Coronavirus disease 2019 pneumonia after admission outside Wuhan, China date: 2020-11-06 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000022980 sha: doc_id: 346459 cord_uid: tkt5ldyo file: cache/cord-346594-tbsxgz43.json key: cord-346594-tbsxgz43 authors: Tang, Sydney C. W.; Lai, Kar Neng title: Peritoneal dialysis: the ideal bridge from conservative therapy to kidney transplant date: 2020-07-11 journal: J Nephrol DOI: 10.1007/s40620-020-00787-0 sha: doc_id: 346594 cord_uid: tbsxgz43 file: cache/cord-346664-ilebaqx3.json key: cord-346664-ilebaqx3 authors: Rahul; Verma, Alka; Yadav, Priyank; Sharma, Vijay Kumar; Sanjeev, Om Prakash title: Non-COVID Surgical Emergency During the Nationwide Lockdown due to Corona Pandemic: a Critical Appraisal date: 2020-08-10 journal: Indian J Surg DOI: 10.1007/s12262-020-02549-5 sha: doc_id: 346664 cord_uid: ilebaqx3 file: cache/cord-346894-iy35298o.json key: cord-346894-iy35298o authors: Miranda-Schaeubinger, Monica; Blumfield, Einat; Chavhan, Govind B.; Farkas, Amy B.; Joshi, Aparna; Kamps, Shawn E.; Kaplan, Summer L.; Sammer, Marla B. K.; Silvestro, Elizabeth; Stanescu, A. Luana; Sze, Raymond W.; Zerr, Danielle M.; Chandra, Tushar; Edwards, Emily A.; Khan, Naeem; Rubio, Eva I.; Vera, Chido D.; Iyer, Ramesh S. title: A primer for pediatric radiologists on infection control in an era of COVID-19 date: 2020-07-07 journal: Pediatr Radiol DOI: 10.1007/s00247-020-04713-1 sha: doc_id: 346894 cord_uid: iy35298o file: cache/cord-347105-my9nioko.json key: cord-347105-my9nioko authors: Foster, Carolyn C.; Steltzer, Michelle; Snyder, Amanda; Alden, Carrie; Helner, Khrystyna; Schinasi, Dana A.; Bohling, Katie; Allen, Kiona title: Integrated Multimodality Telemedicine to Enhance In-Home Care of Infants During the Interstage Period date: 2020-10-20 journal: Pediatr Cardiol DOI: 10.1007/s00246-020-02489-7 sha: doc_id: 347105 cord_uid: my9nioko file: cache/cord-346496-crhv0gnt.json key: cord-346496-crhv0gnt authors: Sun, Ying; Dong, Yanli; Wang, Lifeng; Xie, Huan; Li, Baosen; Chang, Christopher; Wang, Fu-sheng title: Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience date: 2020-04-24 journal: J Autoimmun DOI: 10.1016/j.jaut.2020.102473 sha: doc_id: 346496 cord_uid: crhv0gnt file: cache/cord-347268-vb6z0hzb.json key: cord-347268-vb6z0hzb authors: Wicclair, Mark R. title: Is conscientious objection incompatible with a physician’s professional obligations? date: 2008-08-28 journal: Theor Med Bioeth DOI: 10.1007/s11017-008-9075-z sha: doc_id: 347268 cord_uid: vb6z0hzb file: cache/cord-347064-ljd121no.json key: cord-347064-ljd121no authors: José, Ricardo J.; Brown, Jeremy S. title: Opportunistic bacterial, viral and fungal infections of the lung date: 2016-05-05 journal: Medicine (Abingdon) DOI: 10.1016/j.mpmed.2016.03.015 sha: doc_id: 347064 cord_uid: ljd121no file: cache/cord-347255-fl9lur4h.json key: cord-347255-fl9lur4h authors: May, Larissa; Tatro, Grant; Poltavskiy, Eduard; Mooso, Benjamin; Hon, Simson; Bang, Heejung; Polage, Christopher title: Rapid Multiplex Testing for Upper Respiratory Pathogens in the Emergency Department: A Randomized Controlled Trial date: 2019-11-05 journal: Open Forum Infect Dis DOI: 10.1093/ofid/ofz481 sha: doc_id: 347255 cord_uid: fl9lur4h file: cache/cord-347058-kejcwlng.json key: cord-347058-kejcwlng authors: Akbari, Hamed; Tabrizi, Reza; Lankarani, Kamran B.; Aria, Hamid; Vakili, Sina; Asadian, Fatemeh; Noroozi, Saam; Keshavarz, Pedram; Faramarz, Sanaz title: The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis date: 2020-07-29 journal: Life Sci DOI: 10.1016/j.lfs.2020.118167 sha: doc_id: 347058 cord_uid: kejcwlng file: cache/cord-347293-fp8phk0p.json key: cord-347293-fp8phk0p authors: Kearns, Donovan G.; Chat, Vipawee S.; Uppal, Shelley; Wu, Jashin J. title: Assessing The Risk of Adalimumab Use For Hidradenitis Suppurativa During The COVID-19 Pandemic date: 2020-07-28 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.07.086 sha: doc_id: 347293 cord_uid: fp8phk0p file: cache/cord-346616-kr500kgj.json key: cord-346616-kr500kgj authors: Qian, Song-Zan; Hong, Wan-dong; Lingjie-mao,; Chenfeng-lin,; Zhendong-fang,; Pan, Jing-Ye title: Clinical Characteristics and Outcomes of Severe and Critical Patients With 2019 Novel Coronavirus Disease (COVID-19) in Wenzhou: A Retrospective Study date: 2020-09-04 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.552002 sha: doc_id: 346616 cord_uid: kr500kgj file: cache/cord-346721-l6y3n21b.json key: cord-346721-l6y3n21b authors: Vega, Marisa; Hughes, Francine; Bernstein, Peter S.; Goffman, Dena; Sheen, Jean-Ju; Aubey, Janice J.; Zork, Noelia; Nathan, Lisa title: From the Trenches: Inpatient Management of COVID-19 in Pregnancy date: 2020-06-15 journal: Am J Obstet Gynecol MFM DOI: 10.1016/j.ajogmf.2020.100154 sha: doc_id: 346721 cord_uid: l6y3n21b file: cache/cord-347696-rsjwp0b3.json key: cord-347696-rsjwp0b3 authors: Roberts, Haydn; DeSilva, Gregory title: Reply to the Letter to the Editor: Can Sural Fasciocutaneous Flaps Be Effective in Patients Older Than 65? date: 2020-06-01 journal: Clin Orthop Relat Res DOI: 10.1097/corr.0000000000001333 sha: doc_id: 347696 cord_uid: rsjwp0b3 file: cache/cord-346205-vqgcq3qt.json key: cord-346205-vqgcq3qt authors: Sengillo, Jesse D. title: Importance of Patient Advocacy During the COVID-19 Pandemic date: 2020-09-19 journal: Am J Ophthalmol DOI: 10.1016/j.ajo.2020.07.016 sha: doc_id: 346205 cord_uid: vqgcq3qt file: cache/cord-347375-5ucemm87.json key: cord-347375-5ucemm87 authors: Sazzad, Hossain M.S.; Hossain, M. Jahangir; Gurley, Emily S.; Ameen, Kazi M.H.; Parveen, Shahana; Islam, M. Saiful; Faruque, Labib I.; Podder, Goutam; Banu, Sultana S.; Lo, Michael K.; Rollin, Pierre E.; Rota, Paul A.; Daszak, Peter; Rahman, Mahmudur; Luby, Stephen P. title: Nipah Virus Infection Outbreak with Nosocomial and Corpse-to-Human Transmission, Bangladesh date: 2013-02-17 journal: Emerg Infect Dis DOI: 10.3201/eid1902.120971 sha: doc_id: 347375 cord_uid: 5ucemm87 file: cache/cord-347280-jpwf55l6.json key: cord-347280-jpwf55l6 authors: Skevaki, Chrysanthi; Fragkou, Paraskevi C.; Cheng, Chongsheng; Xie, Min; Renz, Harald title: Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus date: 2020-06-21 journal: J Infect DOI: 10.1016/j.jinf.2020.06.039 sha: doc_id: 347280 cord_uid: jpwf55l6 file: cache/cord-346558-u1e0kzmm.json key: cord-346558-u1e0kzmm authors: Cattaruzza, Maria Sofia; Zagà, Vincenzo; Gallus, Silvano; D’Argenio, Paolo; Gorini, Giuseppe title: Tobacco smoking and COVID-19 pandemic: old and new issues. A summary of the evidence from the scientific literature date: 2020-05-11 journal: Acta Biomed DOI: 10.23750/abm.v91i2.9624 sha: doc_id: 346558 cord_uid: u1e0kzmm file: cache/cord-347607-ydbyonbg.json key: cord-347607-ydbyonbg authors: Spagnuolo, Rocco; Larussa, Tiziana; Iannelli, Chiara; Cosco, Cristina; Nisticò, Eleonora; Manduci, Elena; Bruno, Amalia; Boccuto, Luigi; Abenavoli, Ludovico; Luzza, Francesco; Doldo, Patrizia title: COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey date: 2020-08-13 journal: Medicina (Kaunas) DOI: 10.3390/medicina56080407 sha: doc_id: 347607 cord_uid: ydbyonbg file: cache/cord-347351-emdj66vj.json key: cord-347351-emdj66vj authors: Kampf, Günter; Brüggemann, Yannick; Kaba, Hani E.J.; Steinmann, Joerg; Pfaender, Stephanie; Scheithauer, Simone; Steinmann, Eike title: Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2 date: 2020-09-18 journal: J Hosp Infect DOI: 10.1016/j.jhin.2020.09.022 sha: doc_id: 347351 cord_uid: emdj66vj file: cache/cord-348051-o1hxoasp.json key: cord-348051-o1hxoasp authors: Upadhyaya, Gaurav K.; Iyengar, Karthikeyan; Jain, Vijay K.; Vaishya, Raju title: Challenges and strategies in management of osteoporosis and fragility fracture care during COVID-19 pandemic date: 2020-06-02 journal: J Orthop DOI: 10.1016/j.jor.2020.06.001 sha: doc_id: 348051 cord_uid: o1hxoasp file: cache/cord-347121-5drl3xas.json key: cord-347121-5drl3xas authors: Farah, I.; Lalli, G.; Baker, D.; Schumacher, A. title: A global omics data sharing and analytics marketplace: Case study of a rapid data COVID-19 pandemic response platform. date: 2020-09-29 journal: nan DOI: 10.1101/2020.09.28.20203257 sha: doc_id: 347121 cord_uid: 5drl3xas file: cache/cord-347289-3yi5tz04.json key: cord-347289-3yi5tz04 authors: Poon, L. . C.; Yang, H.; Dumont, S.; Lee, J. C. S.; Copel, J. A.; Danneels, L.; Wright, A.; Costa, F. Da Silva; Leung, T. Y.; Zhang, Y.; Chen, D.; Prefumo, F. title: ISUOG Interim Guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium: information for healthcare professionals – an update date: 2020-06-01 journal: Ultrasound Obstet Gynecol DOI: 10.1002/uog.22061 sha: doc_id: 347289 cord_uid: 3yi5tz04 file: cache/cord-346539-kxnrf5g5.json key: cord-346539-kxnrf5g5 authors: Riggioni, Carmen; Comberiati, Pasquale; Giovannini, Mattia; Agache, Ioana; Akdis, Mübeccel; Alves‐Correia, Magna; Antó, Josep M.; Arcolaci, Alessandra; Kursat Azkur, Ahmet; Azkur, Dilek; Beken, Burcin; Boccabella, Cristina; Bousquet, Jean; Breiteneder, Heimo; Carvalho, Daniela; De las Vecillas, Leticia; Diamant, Zuzana; Eguiluz‐Gracia, Ibon; Eiwegger, Thomas; Eyerich, Stefanie; Fokkens, Wytske; Gao, Ya‐dong; Hannachi, Farah; Johnston, Sebastian L.; Jutel, Marek; Karavelia, Aspasia; Klimek, Ludger; Moya, Beatriz; Nadeau, Kari; O'Hehir, Robyn; O'Mahony, Liam; Pfaar, Oliver; Sanak, Marek; Schwarze, Jürgen; Sokolowska, Milena; Torres, María J.; van de Veen, Willem; van Zelm, Menno C.; Wang, De Yun; Zhang, Luo; Jiménez‐Saiz, Rodrigo; Akdis, Cezmi A. title: A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2 date: 2020-06-14 journal: Allergy DOI: 10.1111/all.14449 sha: doc_id: 346539 cord_uid: kxnrf5g5 file: cache/cord-347414-t88654wo.json key: cord-347414-t88654wo authors: Peng, Mian; Liu, Xueyan; Li, Jinxiu; Ren, Di; Liu, Yongfeng; Meng, Xi; Lyu, Yansi; Chen, Ronglin; Yu, Baojun; Zhong, Weixiong title: Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy date: 2020-08-06 journal: Front Med DOI: 10.1007/s11684-020-0796-3 sha: doc_id: 347414 cord_uid: t88654wo file: cache/cord-347238-yacn6xqk.json key: cord-347238-yacn6xqk authors: Angurala, Mohit; Bala, Manju; Bamber, Sukhvinder Singh; Kaur, Rajbir; Singh, Prabhdeep title: An Internet of Things Assisted Drone Based Approach to Reduce Rapid Spread of Covid-19 date: 2020-07-02 journal: nan DOI: 10.1016/j.jnlssr.2020.06.011 sha: doc_id: 347238 cord_uid: yacn6xqk file: cache/cord-347905-w0fnc43a.json key: cord-347905-w0fnc43a authors: Schwartz, Joseph S.; Tajudeen, Bobby A.; Kennedy, David W. title: Diseases of the nasal cavity date: 2019-10-08 journal: Handb Clin Neurol DOI: 10.1016/b978-0-444-63855-7.00018-6 sha: doc_id: 347905 cord_uid: w0fnc43a file: cache/cord-347277-8bmcd22v.json key: cord-347277-8bmcd22v authors: Huang, Ying hui; Meng, Si jun; Zhang, Yi; Wu, Shui sheng; Zhang, Yu; Zhang, Ya wei; Ye, Yi xiang; Wei, Qi feng; Zhao, Nian gui; Jiang, Jian ping; Ji, Xiao ying; Zhou, Chun xia; Zheng, Chao; Zhang, Wen; Xie, Li zhong; Hu, Yong chao; He, Jian quan; Chen, Jian; Wang, Wang yue; Zhang, Chang hua; Cao, Liming; Xu, Wen; Lei, Yunhong; Jian, Zheng hua; Hu, Wei ping; Qin, Wen juan; Wang, Wan yu; He, Yu long; Xiao, Hang; Zheng, Xiao fang; Hu, Yi Qun; Pan, Wen Sheng; Cai, Jian feng title: The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods date: 2020-04-10 journal: nan DOI: 10.1101/2020.04.07.20051060 sha: doc_id: 347277 cord_uid: 8bmcd22v file: cache/cord-348422-werg9ofa.json key: cord-348422-werg9ofa authors: Shamsah, Mohammed A; Bitar, Zouheir Ibrahim; Alfoudri, Huda title: Right atrial thrombus in a patient with COVID-19 pneumonia: a case report date: 2020-09-04 journal: Eur Heart J Case Rep DOI: 10.1093/ehjcr/ytaa296 sha: doc_id: 348422 cord_uid: werg9ofa file: cache/cord-347697-uz0i6wfp.json key: cord-347697-uz0i6wfp authors: McLean, Ross C.; Young, John; Musbahi, Aya; Lee, Jing Xian; Hidayat, Hena; Abdalla, Nagi; Chowdhury, Sabyasachi; Baker, Elizabeth A.; Etherson, Kevin Jon title: A single-centre observational cohort study to evaluate volume and severity of emergency general surgery admissions during the COVID-19 pandemic: is there a “lockdown” effect? date: 2020-09-12 journal: Int J Surg DOI: 10.1016/j.ijsu.2020.09.011 sha: doc_id: 347697 cord_uid: uz0i6wfp file: cache/cord-348202-6we8e60b.json key: cord-348202-6we8e60b authors: Drake, Daniel H.; De Bonis, Michele; Covella, Michele; Agricola, Eustachio; Zangrillo, Alberto; Zimmerman, Karen G.; Cobey, Frederick C. title: Echo in Pandemic: Front Line Perspective, Expanding Role of Ultrasound and Ethics of Resource Allocation date: 2020-04-10 journal: J Am Soc Echocardiogr DOI: 10.1016/j.echo.2020.04.007 sha: doc_id: 348202 cord_uid: 6we8e60b file: cache/cord-348501-8cvtqj7w.json key: cord-348501-8cvtqj7w authors: Beyzaee, Amir Mohammad; Rahmatpour Rokni, Ghasem; Patil, Anant; Goldust, Mohamad title: Rituximab as the treatment of pemphigus vulgaris in the COVID‐19 pandemic era: A narrative review date: 2020-10-20 journal: Dermatol Ther DOI: 10.1111/dth.14405 sha: doc_id: 348501 cord_uid: 8cvtqj7w file: cache/cord-347752-2ejnva4u.json key: cord-347752-2ejnva4u authors: Mrabti, Hind; Berrada, Narjiss; Raiss, Ghislaine; Ettahri, Hamza; Abahssain, Halima; Bourhafour, Mouna; Sahraoui, Souha; Errihani, Hassan title: Cancer management challenge in a developing country in COVID-19 pandemic: reflection of a group of Moroccan oncologists date: 2020-06-25 journal: Future oncology DOI: 10.2217/fon-2020-0450 sha: doc_id: 347752 cord_uid: 2ejnva4u file: cache/cord-348458-dwj90mbq.json key: cord-348458-dwj90mbq authors: Narula, Nupoor; Singh, Harsimran S. title: Cardiology Practice and Training Post-COVID-19: Achieving “Normalcy” After Disruption date: 2020-06-22 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2020.06.036 sha: doc_id: 348458 cord_uid: dwj90mbq file: cache/cord-348881-w0moe21t.json key: cord-348881-w0moe21t authors: Creel-Bulos, Christina; Hockstein, Maxwell; Amin, Neha; Melhem, Samer; Truong, Alexander; Sharifpour, Milad title: Acute Cor Pulmonale in Critically Ill Patients with Covid-19 date: 2020-05-06 journal: N Engl J Med DOI: 10.1056/nejmc2010459 sha: doc_id: 348881 cord_uid: w0moe21t file: cache/cord-348172-q3zcn5pf.json key: cord-348172-q3zcn5pf authors: Poli, Daniela; Tosetto, Alberto; Palareti, Gulatiero; Barcellona, Doris; Ciampa, Antonio; Grandone, Elvira; Manotti, Cesare; Moia, Marco; Squizzato, Alessandro; Toschi, Vincenzo; Testa, Sophie title: Managing anticoagulation in the COVID-19 era between lockdown and reopening phases date: 2020-06-08 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02391-3 sha: doc_id: 348172 cord_uid: q3zcn5pf file: cache/cord-348672-e34103b1.json key: cord-348672-e34103b1 authors: Zhang, Jiaqi; Bai, Wenliang; Guo, Chao; Liu, Lei; Wang, Guige; Huang, Cheng; Chen, Yeye; Zhang, Ye; Li, Shanqing title: Postoperative Short-term Outcomes Between Sublobar Resection and Lobectomy in Patients with Lung Adenocarcinoma date: 2020-10-01 journal: Cancer Manag Res DOI: 10.2147/cmar.s266376 sha: doc_id: 348672 cord_uid: e34103b1 file: cache/cord-348975-plne3xlz.json key: cord-348975-plne3xlz authors: Wagner, Tyler; Shweta, FNU; Murugadoss, Karthik; Awasthi, Samir; Venkatakrishnan, AJ; Bade, Sairam; Puranik, Arjun; Kang, Martin; Pickering, Brian W; O'Horo, John C; Bauer, Philippe R; Razonable, Raymund R; Vergidis, Paschalis; Temesgen, Zelalem; Rizza, Stacey; Mahmood, Maryam; Wilson, Walter R; Challener, Douglas; Anand, Praveen; Liebers, Matt; Doctor, Zainab; Silvert, Eli; Solomon, Hugo; Anand, Akash; Barve, Rakesh; Gores, Gregory; Williams, Amy W; Morice, William G; Halamka, John; Badley, Andrew; Soundararajan, Venky title: Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis date: 2020-07-07 journal: eLife DOI: 10.7554/elife.58227 sha: doc_id: 348975 cord_uid: plne3xlz file: cache/cord-348430-8xk4dt7t.json key: cord-348430-8xk4dt7t authors: Bragazzi, Nicola Luigi; Riccò, Matteo; Pacifico, Alessia; Malagoli, Piergiorgio; Kridin, Khalaf; Pigatto, Paolo; Damiani, Giovanni title: COVID‐19 knowledge prevents biologics discontinuation: Data from an Italian multicenter survey during RED‐ZONE declaration date: 2020-05-28 journal: Dermatol Ther DOI: 10.1111/dth.13508 sha: doc_id: 348430 cord_uid: 8xk4dt7t file: cache/cord-348423-zq86ms8w.json key: cord-348423-zq86ms8w authors: Louvardi, Maya; Pelekasis, Panagiotis; Chrousos, George P.; Darviri, Christina title: Mental health in chronic disease patients during the COVID-19 quarantine in Greece date: 2020-06-29 journal: Palliative & supportive care DOI: 10.1017/s1478951520000528 sha: doc_id: 348423 cord_uid: zq86ms8w file: cache/cord-348813-v1sdodz9.json key: cord-348813-v1sdodz9 authors: Kefale, Belayneh; Tegegne, Gobezie T.; Degu, Amsalu; Tadege, Melaku; Tesfa, Desalegn title: Prevalence and Risk Factors of Thromboembolism among Patients With Coronavirus Disease-19: A Systematic Review and Meta-Analysis date: 2020-10-19 journal: Clin Appl Thromb Hemost DOI: 10.1177/1076029620967083 sha: doc_id: 348813 cord_uid: v1sdodz9 file: cache/cord-348855-lnltoj1n.json key: cord-348855-lnltoj1n authors: Iannaccone, Giulia; Scacciavillani, Roberto; Del Buono, Marco Giuseppe; Camilli, Massimiliano; Ronco, Claudio; Lavie, Carl J.; Abbate, Antonio; Crea, Filippo; Massetti, Massimo; Aspromonte, Nadia title: Weathering the Cytokine Storm in COVID-19: Therapeutic Implications date: 2020-06-29 journal: Cardiorenal Med DOI: 10.1159/000509483 sha: doc_id: 348855 cord_uid: lnltoj1n file: cache/cord-348130-t9tysvr8.json key: cord-348130-t9tysvr8 authors: Cho, Sung-Yeon; Lee, Hyeon-Jeong; Lee, Dong-Gun title: Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea date: 2018-02-27 journal: Korean J Intern Med DOI: 10.3904/kjim.2018.036 sha: doc_id: 348130 cord_uid: t9tysvr8 file: cache/cord-348578-chfb4i15.json key: cord-348578-chfb4i15 authors: Bulman, Julie C.; Moussa, Marwan; Lewis, Trevor K.; Berkowitz, Seth; Sarwar, Ammar; Faintuch, Salomao; Ahmed, Muneeb title: Transitioning the IR Clinic to Telehealth: A Single-Center Experience during the COVID-19 Pandemic date: 2020-06-30 journal: J Vasc Interv Radiol DOI: 10.1016/j.jvir.2020.05.008 sha: doc_id: 348578 cord_uid: chfb4i15 file: cache/cord-349031-tbof9yqi.json key: cord-349031-tbof9yqi authors: Chen, Shiu-Jau; Wang, Shao-Cheng; Chen, Yuan-Chuan title: Novel Antiviral Strategies in the Treatment of COVID-19: A Review date: 2020-08-20 journal: Microorganisms DOI: 10.3390/microorganisms8091259 sha: doc_id: 349031 cord_uid: tbof9yqi file: cache/cord-348755-2g5gi1du.json key: cord-348755-2g5gi1du authors: Chow, D. S.; Glabis-Bloom, J.; Soun, J.; Weinberg, B.; Berens-Loveless, T.; Xie, X.; Mutasa, S.; Monuki, E.; Park, J. I.; Bota, D.; Wu, J.; Thompson, L.; Boden-Albala, B.; Khan, S.; Amin, A.; Chang, P. title: Development and External Validation of a Prognostic Tool for COVID-19 Critical Disease date: 2020-05-11 journal: nan DOI: 10.1101/2020.05.06.20093435 sha: doc_id: 348755 cord_uid: 2g5gi1du file: cache/cord-349144-cvmebr3f.json key: cord-349144-cvmebr3f authors: Barca, Ida; Novembre, Daniela; Giofrè, Elio; Caruso, Davide; Cordaro, Raffaella; Kallaverja, Elvis; Ferragina, Francesco; Cristofaro, Maria Giulia title: Telemedicine in Oral and Maxillo-Facial Surgery: An Effective Alternative in Post COVID-19 Pandemic date: 2020-10-09 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17207365 sha: doc_id: 349144 cord_uid: cvmebr3f file: cache/cord-347263-ci6mv72z.json key: cord-347263-ci6mv72z authors: Berekashvili, k.; Dmytriw, A. A.; Vulkanov, V.; Agarwal, S.; Khaneja, A.; Turkel-Parella, D.; Liff, J.; Farkas, J.; Nandakumar, T.; Zhou, T.; Frontera, J.; Kahn, D. E.; Kim, S.; Humbert, K. A.; Sanger, M. D.; Yaghi, S.; Lord, A.; Arcot, K.; Tiwari, A. title: Etiologic Subtypes of Ischemic Stroke in SARS-COV-2 Virus patients date: 2020-05-08 journal: nan DOI: 10.1101/2020.05.03.20077206 sha: doc_id: 347263 cord_uid: ci6mv72z file: cache/cord-348879-opzkodt7.json key: cord-348879-opzkodt7 authors: Nune, A.; Iyengar, K.; Ahmed, A.; Sapkota, H. title: Challenges in delivering rheumatology care during COVID-19 pandemic date: 2020-07-25 journal: Clin Rheumatol DOI: 10.1007/s10067-020-05312-z sha: doc_id: 348879 cord_uid: opzkodt7 file: cache/cord-348570-plds5kbn.json key: cord-348570-plds5kbn authors: Buneviciene, Inesa; Mekary, Rania A.; Smith, Timothy R.; Onnela, Jukka-Pekka; Bunevicius, Adomas title: Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis date: 2020-10-20 journal: Crit Rev Oncol Hematol DOI: 10.1016/j.critrevonc.2020.103123 sha: doc_id: 348570 cord_uid: plds5kbn file: cache/cord-349280-12hc3mhq.json key: cord-349280-12hc3mhq authors: Drake, Justin A.; Stiles, Zachary E.; Tsao, Miriam W.; Deneve, Jeremiah L.; Glazer, Evan S.; Yakoub, Danny; Grothey, Axel; Somer, Bradley G.; Dickson, Paxton V. title: Analysis of the Survival Impact of Postoperative Chemotherapy After Preoperative Chemotherapy and Resection for Gastric Cancer date: 2020-08-27 journal: Ann Surg Oncol DOI: 10.1245/s10434-020-09045-w sha: doc_id: 349280 cord_uid: 12hc3mhq file: cache/cord-349263-mmfrqyrc.json key: cord-349263-mmfrqyrc authors: Rodríguez, A.; Moreno, G.; Gómez, J.; Carbonell, R.; Picó-Plana, E.; Benavent Bofill, C.; Sánchez Parrilla, R.; Trefler, S.; Esteve Pitarch, E.; Canadell, L.; Teixido, X.; Claverias, L.; Bodí, M. title: Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic date: 2020-11-09 journal: nan DOI: 10.1016/j.medine.2020.05.005 sha: doc_id: 349263 cord_uid: mmfrqyrc file: cache/cord-349329-f0pbd968.json key: cord-349329-f0pbd968 authors: Bosteels, Cedric; Maes, Bastiaan; Van Damme, Karel; De Leeuw, Elisabeth; Declercq, Jozefien; Delporte, Anja; Demeyere, Bénédicte; Vermeersch, Stéfanie; Vuylsteke, Marnik; Willaert, Joren; Bollé, Laura; Vanbiervliet, Yuri; Decuypere, Jana; Libeer, Frederick; Vandecasteele, Stefaan; Peene, Isabelle; Lambrecht, Bart title: Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-05 journal: Trials DOI: 10.1186/s13063-020-04451-7 sha: doc_id: 349329 cord_uid: f0pbd968 file: cache/cord-349210-8t4a5qqo.json key: cord-349210-8t4a5qqo authors: Ji, Ping; Chen, Jianmeng; Golding, Amit; Nikolov, Nikolay P.; Saluja, Bhawana; Ren, Yunzhao R.; Sahajwalla, Chandrahas title: Immunomodulatory Therapeutic Proteins in COVID‐19: Current Clinical Development and Clinical Pharmacology Considerations date: 2020-08-10 journal: J Clin Pharmacol DOI: 10.1002/jcph.1729 sha: doc_id: 349210 cord_uid: 8t4a5qqo file: cache/cord-348364-jb0lvhq5.json key: cord-348364-jb0lvhq5 authors: Rehman, Tyler; Josephson, Greta; Sunbuli, Moutaz; Chadaga, Amar R. title: Spontaneous Pneumothorax in an Elderly Patient With Coronavirus Disease (COVID-19) Pneumonia date: 2020 journal: Ochsner J DOI: 10.31486/toj.20.0072 sha: doc_id: 348364 cord_uid: jb0lvhq5 file: cache/cord-349396-a6zyioc1.json key: cord-349396-a6zyioc1 authors: Tsurumi, Amy; Flaherty, Patrick J.; Que, Yok-Ai; Ryan, Colleen M.; Mendoza, April E.; Almpani, Marianna; Bandyopadhaya, Arunava; Ogura, Asako; Dhole, Yashoda V.; Goodfield, Laura F.; Tompkins, Ronald G.; Rahme, Laurence G. title: Multi-biomarker Prediction Models for Multiple Infection Episodes Following Blunt Trauma date: 2020-10-07 journal: iScience DOI: 10.1016/j.isci.2020.101659 sha: doc_id: 349396 cord_uid: a6zyioc1 file: cache/cord-349500-603v8lfb.json key: cord-349500-603v8lfb authors: Neurath, Markus F title: Covid-19 and immunomodulation in IBD date: 2020-04-16 journal: Gut DOI: 10.1136/gutjnl-2020-321269 sha: doc_id: 349500 cord_uid: 603v8lfb file: cache/cord-349533-51cex2sl.json key: cord-349533-51cex2sl authors: Yeoh, Su-Ann; Ehrenstein, Michael R title: Are treat-to-target and dose tapering strategies for rheumatoid arthritis possible during the COVID-19 pandemic? date: 2020-06-08 journal: Lancet Rheumatol DOI: 10.1016/s2665-9913(20)30175-2 sha: doc_id: 349533 cord_uid: 51cex2sl file: cache/cord-349565-g1emvmdu.json key: cord-349565-g1emvmdu authors: Conti, Clara Benedetta; Henchi, Sonia; Coppeta, Giovanni Paolo; Testa, Sophie; Grassia, Roberto title: Bleeding in COVID-19 severe pneumonia: The other side of abnormal coagulation pattern? date: 2020-05-07 journal: Eur J Intern Med DOI: 10.1016/j.ejim.2020.05.002 sha: doc_id: 349565 cord_uid: g1emvmdu file: cache/cord-349678-79zlgjqi.json key: cord-349678-79zlgjqi authors: Warrior, Krishnan; Chung, Paul A.; Ahmed, Nida; Soult, Michael C.; Simpson, Kevin P. title: Acute Limb Ischemia Due to Arterial Thrombosis Associated With Coronavirus Disease 2019 date: 2020-06-11 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000140 sha: doc_id: 349678 cord_uid: 79zlgjqi file: cache/cord-350052-9431xqu1.json key: cord-350052-9431xqu1 authors: Kim, Ji Heui; Moon, Byoung Jae; Gong, Chang-Hoon; Kim, Nam Hee; Jang, Yong Ju title: Detection of respiratory viruses in adult patients with perennial allergic rhinitis date: 2013-09-14 journal: Ann Allergy Asthma Immunol DOI: 10.1016/j.anai.2013.08.024 sha: doc_id: 350052 cord_uid: 9431xqu1 file: cache/cord-349566-zx9kt144.json key: cord-349566-zx9kt144 authors: de Alencar, Julio Cesar Garcia; Moreira, Claudia de Lucena; Müller, Alicia Dudy; Chaves, Cleuber Esteves; Fukuhara, Marina Akemi; da Silva, Elizabeth Aparecida; Miyamoto, Maria de Fátima Silva; Pinto, Vanusa Barbosa; Bueno, Cauê Gasparotto; Lazar, Felippe; Gomez, Luz Marina; Menezes, Maria Clara Saad; Marchini, Julio Flavio Meirelles; Marino, Lucas Oliveira; Brandão, Rodrigo Antônio; Souza, Heraldo Possolo title: Double-blind, randomized, placebo-controlled trial with N-acetylcysteine for treatment of severe acute respiratory syndrome caused by COVID-19 date: 2020-09-23 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1443 sha: doc_id: 349566 cord_uid: zx9kt144 file: cache/cord-350065-frg7gvf5.json key: cord-350065-frg7gvf5 authors: Parolari, Alessandro; di Mauro, Michele; Bonalumi, Giorgia; Barili, Fabio; Garatti, Andrea; Carretta, Giovanni; Donato, Daniele; Pagano, Domenico; Gerosa, Gino title: Safety for all: coronavirus disease 2019 pandemic and cardiac surgery: a roadmap to ‘phase’ 2 date: 2020-05-11 journal: Eur J Cardiothorac Surg DOI: 10.1093/ejcts/ezaa187 sha: doc_id: 350065 cord_uid: frg7gvf5 file: cache/cord-350232-zml4o93t.json key: cord-350232-zml4o93t authors: Peck, Richard W; Weiner, Daniel; Cook, Jack; Powell, J Robert title: A Real‐World Evidence Framework for Optimising Dosing in All Patients with COVID‐19 date: 2020-05-23 journal: Clin Pharmacol Ther DOI: 10.1002/cpt.1922 sha: doc_id: 350232 cord_uid: zml4o93t file: cache/cord-349740-xed4aybr.json key: cord-349740-xed4aybr authors: Wang, Yulong; Zeng, Lian; Yao, Sheng; Zhu, Fengzhao; Liu, Chaozong; Di Laura, Anna; Henckel, Johann; Shao, Zengwu; Hirschmann, Michael T.; Hart, Alister; Guo, Xiaodong title: Recommendations of protective measures for orthopedic surgeons during COVID-19 pandemic date: 2020-06-10 journal: Knee Surg Sports Traumatol Arthrosc DOI: 10.1007/s00167-020-06092-4 sha: doc_id: 349740 cord_uid: xed4aybr file: cache/cord-349838-p6vfzbla.json key: cord-349838-p6vfzbla authors: Algwaiz, Ghada; Aljurf, Mahmoud; Koh, Mickey; Horowitz, Mary M.; Ljungman, Per; Weisdorf, Daniel; Saber, Wael; Kodera, Yoshihisa; Szer, Jeff; Jawdat, Dunia; Wood, William A.; Brazauskas, Ruta; Lehmann, Leslie; Pasquini, Marcelo C.; Seber, Adriana; Lu, Pei Hua; Atsuta, Yoshiko; Riches, Marcie; Perales, Miguel-Angel; Worel, Nina; Okamoto, Shinichiro; Srivastava, Alok; Chemaly, Roy F.; Cordonnier, Catherine; Dandoy, Christopher E.; Wingard, John R.; Kharfan-Dabaja, Mohamed A.; Hamadani, Mehdi; Majhail, Navneet S.; Waghmare, Alpana A.; Chao, Nelson; Kröger, Nicolaus; Shaw, Bronwen; Mohty, Mohamad; Niederwieser, Dietger; Greinix, Hildegard; Hashmi, Shahrukh K. title: Real-world issues and potential solutions in HCT during the COVID-19 pandemic: Perspectives from the WBMT and the CIBMTR's Health Services and International Studies Committee date: 2020-07-24 journal: Biol Blood Marrow Transplant DOI: 10.1016/j.bbmt.2020.07.021 sha: doc_id: 349838 cord_uid: p6vfzbla file: cache/cord-349958-126yb5se.json key: cord-349958-126yb5se authors: Raskin, Jo; Lebeer, Marnix; De Bondt, Charlotte; Wener, Reinier; Janssens, Annelies; van Meerbeeck, Jan P. title: CANCER IN THE TIME OF COVID: Expert opinion on how to adapt current practice date: 2020-04-16 journal: Eur Respir J DOI: 10.1183/13993003.00959-2020 sha: doc_id: 349958 cord_uid: 126yb5se file: cache/cord-350166-loxe11d6.json key: cord-350166-loxe11d6 authors: Garmendia, Onintza; Rodríguez-Lazaro, Miguel A.; Otero, Jorge; Phan, Phuong; Stoyanova, Alexandrina; Dinh-Xuan, Anh Tuan; Gozal, David; Navajas, Daniel; Montserrat, Josep M.; Farré, Ramon title: Low-cost, easy-to-build non-invasive pressure support ventilator for under-resourced regions: open source hardware description, performance and feasibility testing date: 2020-04-20 journal: Eur Respir J DOI: 10.1183/13993003.00846-2020 sha: doc_id: 350166 cord_uid: loxe11d6 file: cache/cord-349949-jp0hvcg6.json key: cord-349949-jp0hvcg6 authors: Freer, Phoebe E. title: The impact of the COVID-19 pandemic on Breast Imaging date: 2020-09-22 journal: Radiol Clin North Am DOI: 10.1016/j.rcl.2020.09.008 sha: doc_id: 349949 cord_uid: jp0hvcg6 file: cache/cord-349360-dv4lxx52.json key: cord-349360-dv4lxx52 authors: Cozza, Valerio; Fransvea, Pietro; La Greca, Antonio; De Paolis, Paolo; Marini, Pierluigi; Zago, Mauro; Sganga, Gabriele title: I-ACTSS-COVID-19—the Italian acute care and trauma surgery survey for COVID-19 pandemic outbreak date: 2020-06-24 journal: Updates Surg DOI: 10.1007/s13304-020-00832-4 sha: doc_id: 349360 cord_uid: dv4lxx52 file: cache/cord-350437-dq1il88y.json key: cord-350437-dq1il88y authors: Reale, Maria Lucia; Bironzo, Paolo; Bertaglia, Valentina; Palesandro, Erica; Leone, Gianmarco; Tabbò, Fabrizio; Bungaro, Maristella; Audisio, Marco; Mariniello, Annapaola; Rapetti, Simonetta G.; Di Stefano, Rosario F.; Artusio, Elisa; Capelletto, Enrica; Sperone, Paola; Boccuzzi, Adriana; Calandri, Marco; Perboni, Alberto; Malapelle, Umberto; Passiglia, Francesco; Novello, Silvia title: SARS-CoV-2 Infection in Cancer Patients: A Picture of an Italian Onco-Covid Unit date: 2020-08-19 journal: Front Oncol DOI: 10.3389/fonc.2020.01722 sha: doc_id: 350437 cord_uid: dq1il88y file: cache/cord-349076-x3rjasg0.json key: cord-349076-x3rjasg0 authors: Jarczak, Dominik; Kluge, Stefan; Nierhaus, Axel title: Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View date: 2020-08-03 journal: Int J Mol Sci DOI: 10.3390/ijms21155543 sha: doc_id: 349076 cord_uid: x3rjasg0 file: cache/cord-349439-3z0b77r5.json key: cord-349439-3z0b77r5 authors: Mandal, Amitabha; Nandi, Sourabh; Chhebbi, Madiwalesh; Basu, Abhijit; Ray, Mukurdipi title: A Systematic Review on Tracheostomy in COVID-19 Patients: Current Guidelines and Safety Measures date: 2020-09-28 journal: Indian J Otolaryngol Head Neck Surg DOI: 10.1007/s12070-020-02152-w sha: doc_id: 349439 cord_uid: 3z0b77r5 file: cache/cord-349561-4mkiwg9k.json key: cord-349561-4mkiwg9k authors: Porta, Alessandra Della; Bornstein, Kasha; Coye, Austin; Montrief, Tim; Long, Brit; Parris, Mehruba Anwar title: Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians date: 2020-07-19 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.07.030 sha: doc_id: 349561 cord_uid: 4mkiwg9k file: cache/cord-350325-vu8v9epr.json key: cord-350325-vu8v9epr authors: Malih, Narges; Hajinasrollah, Ghazal; Zare, Marjan; Taheri, Mahboobeh title: Unexpected Presentation of COVID-19 in a 38-Year-Old Male Patient: A Case Report date: 2020-07-29 journal: Case Rep Dermatol DOI: 10.1159/000509994 sha: doc_id: 350325 cord_uid: vu8v9epr file: cache/cord-350131-rsrlri8m.json key: cord-350131-rsrlri8m authors: Amer, Mohamed A.; El-Sherif, Hossam S.; Abdel-Hamid, Ahmed S.; El-Zayat, Saad title: Early recovery patterns of olfactory disorders in COVID-19 patients; a clinical cohort study date: 2020-09-14 journal: Am J Otolaryngol DOI: 10.1016/j.amjoto.2020.102725 sha: doc_id: 350131 cord_uid: rsrlri8m file: cache/cord-348535-tvs1snq8.json key: cord-348535-tvs1snq8 authors: Ottaviani, Silvia; Stebbing, Justin title: What is the best drug to treat COVID-19? The need for randomized controlled trials date: 2020-05-19 journal: Med DOI: 10.1016/j.medj.2020.04.002 sha: doc_id: 348535 cord_uid: tvs1snq8 file: cache/cord-350408-rqlkwoya.json key: cord-350408-rqlkwoya authors: Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A.; Aerts, Stein; Amit, Ido; Bertero, Michela G.; Bock, Christoph; Bredenoord, Annelien L.; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; De Strooper, Bart; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M.; Figlerowicz, Marek; Gasser, Susan M.; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A.; Krabbe, Grietje; Lichter, Peter; Linnarsson, Sten; Marine, Jean-Christophe; Marioni, John C.; Marti-Renom, Marc A.; Netea, Mihai G.; Nickel, Dörthe; Nollmann, Marcelo; Novak, Halina R.; Parkinson, Helen; Piccolo, Stefano; Pinheiro, Inês; Pombo, Ana; Popp, Christian; Reik, Wolf; Roman-Roman, Sergio; Rosenstiel, Philip; Schultze, Joachim L.; Stegle, Oliver; Tanay, Amos; Testa, Giuseppe; Thanos, Dimitris; Theis, Fabian J.; Torres-Padilla, Maria-Elena; Valencia, Alfonso; Vallot, Céline; van Oudenaarden, Alexander; Vidal, Marie; Voet, Thierry title: LifeTime and improving European healthcare through cell-based interceptive medicine date: 2020-09-07 journal: Nature DOI: 10.1038/s41586-020-2715-9 sha: doc_id: 350408 cord_uid: rqlkwoya file: cache/cord-350179-ltk5hfc4.json key: cord-350179-ltk5hfc4 authors: Paganini, Matteo; Conti, Andrea; Weinstein, Eric; Della Corte, Francesco; Ragazzoni, Luca title: Translating COVID-19 Pandemic Surge Theory to Practice in the Emergency Department: How to Expand Structure date: 2020-03-27 journal: Disaster medicine and public health preparedness DOI: 10.1017/dmp.2020.57 sha: doc_id: 350179 cord_uid: ltk5hfc4 file: cache/cord-350529-yqtu059x.json key: cord-350529-yqtu059x authors: Evans, Samantha; Taylor, Claire; Antoniou, Anthony; Aggarwal, Tushar; Burns, Elaine; Jenkins, John T; Miskovic, Danilo title: Implementation of a clinical pathway for the surgical treatment of colorectal cancer during the COVID‐19 pandemic date: 2020-07-12 journal: Colorectal Dis DOI: 10.1111/codi.15247 sha: doc_id: 350529 cord_uid: yqtu059x file: cache/cord-350338-lcsa06gm.json key: cord-350338-lcsa06gm authors: Wang, Kun; Zuo, Peiyuan; Liu, Yuwei; Zhang, Meng; Zhao, Xiaofang; Xie, Songpu; Zhang, Hao; Chen, Xinglin; Liu, Chengyun title: Clinical and laboratory predictors of in-hospital mortality in patients with COVID-19: a cohort study in Wuhan, China date: 2020-05-03 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa538 sha: doc_id: 350338 cord_uid: lcsa06gm file: cache/cord-350401-suefuurq.json key: cord-350401-suefuurq authors: Lima-Setta, Fernanda; Magalhães-Barbosa, Maria Clara de; Rodrigues-Santos, Gustavo; Figueiredo, Elaine Augusta das Neves; Jacques, Melissa de Lorena; Zeitel, Raquel de Seixas; Sapolnik, Roberto; Borges, Cibelle Teixeira da Siva; Lanziotti, Vanessa Soares; Castro, Roberta Esteves Vieira de; Bellinat, Ana Paula Novaes; Silva, Thiago Peres da; Oliveira, Felipe Rezende Caino de; Reis, Bárbara Carvalho Santos dos; Castro, Natália Almeida de Arnaldo Silva Rodriguez; Macedo, João Henrique Garcia Cobas; Scarlato, Ana Carolina Cabral Pinheiro; Riveiro, Paula Marins; Mota, Isabele Coelho Fonseca da; Lorenzo, Vivian Botelho; Lucena, Natalia Martins Lima de; Azevedo, Zina Maria Almeida de; Cunha, Antonio José L.A.; Prata-Barbosa, Arnaldo title: Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study()()() date: 2020-11-09 journal: J Pediatr (Rio J) DOI: 10.1016/j.jped.2020.10.008 sha: doc_id: 350401 cord_uid: suefuurq file: cache/cord-350594-0zxq4lxc.json key: cord-350594-0zxq4lxc authors: Patel, Ishan; Akoluk, Arda; Douedi, Steven; Upadhyaya, Vandan; Mazahir, Usman; Costanzo, Eric; Flynn, Daniel title: Life-Threatening Psoas Hematoma due to Retroperitoneal Hemorrhage in a COVID-19 Patient on Enoxaparin Treated With Arterial Embolization: A Case Report date: 2020-06-25 journal: J Clin Med Res DOI: 10.14740/jocmr4256 sha: doc_id: 350594 cord_uid: 0zxq4lxc file: cache/cord-350679-69lv4wbz.json key: cord-350679-69lv4wbz authors: Shinde, Rajesh S.; Naik, Mekhala D.; Shinde, Shital R.; Bhandare, Manish S.; Chaudhari, Vikram A.; Shrikhande, Shailesh V.; Dcruz, Anil K. title: To Do or Not to Do?—A Review of Cancer Surgery Triage Guidelines in COVID-19 Pandemic date: 2020-05-11 journal: Indian J Surg Oncol DOI: 10.1007/s13193-020-01086-7 sha: doc_id: 350679 cord_uid: 69lv4wbz file: cache/cord-349775-zwslhjju.json key: cord-349775-zwslhjju authors: Brittain-Long, Robin; Westin, Johan; Olofsson, Sigvard; Lindh, Magnus; Andersson, Lars-Magnus title: Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial date: 2011-04-26 journal: BMC Med DOI: 10.1186/1741-7015-9-44 sha: doc_id: 349775 cord_uid: zwslhjju file: cache/cord-350990-tywbe4o2.json key: cord-350990-tywbe4o2 authors: Checchi, Vittorio; Bellini, Pierantonio; Bencivenni, Davide; Consolo, Ugo title: COVID‐19 dentistry‐related aspects: a literature overview date: 2020-07-05 journal: Int Dent J DOI: 10.1111/idj.12601 sha: doc_id: 350990 cord_uid: tywbe4o2 file: cache/cord-351224-jeedo5mc.json key: cord-351224-jeedo5mc authors: GeurtsvanKessel, Corine H.; Okba, Nisreen M. A.; Igloi, Zsofia; Bogers, Susanne; Embregts, Carmen W. E.; Laksono, Brigitta M.; Leijten, Lonneke; Rokx, Casper; Rijnders, Bart; Rahamat-Langendoen, Janette; van den Akker, Johannes P. C.; van Kampen, Jeroen J. A.; van der Eijk, Annemiek A.; van Binnendijk, Rob S.; Haagmans, Bart; Koopmans, Marion title: An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment date: 2020-07-06 journal: Nat Commun DOI: 10.1038/s41467-020-17317-y sha: doc_id: 351224 cord_uid: jeedo5mc file: cache/cord-350589-h6hotlqk.json key: cord-350589-h6hotlqk authors: Cieszanowski, Andrzej; Czekajska, Elżbieta; Giżycka, Barbara; Gruszczyńska, Katarzyna; Podgórska, Joanna; Oronowicz-Jaśkowiak, Agnieszka; Serafin, Zbigniew; Szurowska, Edyta; Walecki, Jerzy M. title: Management of patients with COVID-19 in radiology departments, and indications regarding imaging studies – recommendations of the Polish Medical Society of Radiology date: 2020-04-29 journal: Pol J Radiol DOI: 10.5114/pjr.2020.95022 sha: doc_id: 350589 cord_uid: h6hotlqk file: cache/cord-350737-nrtrhq1f.json key: cord-350737-nrtrhq1f authors: Chen, Xinchun; Zhou, Boping; Li, Meizhong; Liang, Xiaorong; Wang, Huosheng; Yang, Guilin; Wang, Hui; Le, Xiaohua title: Serology of Severe Acute Respiratory Syndrome: Implications for Surveillance and Outcome date: 2004-04-01 journal: J Infect Dis DOI: 10.1086/380397 sha: doc_id: 350737 cord_uid: nrtrhq1f file: cache/cord-350904-wyg8ikph.json key: cord-350904-wyg8ikph authors: Gubernatorova, E.O.; Gorshkova, E.A.; Polinova, A.I.; Drutskaya, M.D. title: IL-6: relevance for immunopathology of SARS-CoV-2 date: 2020-05-20 journal: Cytokine Growth Factor Rev DOI: 10.1016/j.cytogfr.2020.05.009 sha: doc_id: 350904 cord_uid: wyg8ikph file: cache/cord-351195-2fdqu2l1.json key: cord-351195-2fdqu2l1 authors: nan title: How to manage, after containment, patients with chronic conditions at risk? date: 2020-07-12 journal: Bull Acad Natl Med DOI: 10.1016/j.banm.2020.07.014 sha: doc_id: 351195 cord_uid: 2fdqu2l1 file: cache/cord-351446-j4ambec5.json key: cord-351446-j4ambec5 authors: Sinonquel, P.; Roelandt, P.; Demedts, I.; van Gerven, L.; Vandenbriele, C.; Wilmer, A.; Van Wijngaerden, E.; Bisschops, R. title: COVID‐19 and gastrointestinal endoscopy: what should be taken into account? date: 2020-04-26 journal: Dig Endosc DOI: 10.1111/den.13706 sha: doc_id: 351446 cord_uid: j4ambec5 file: cache/cord-350200-1w5u3w8i.json key: cord-350200-1w5u3w8i authors: Hendren, Elizabeth M.; Matthews, Nicola; Oliver, Mathew; Rice, Julie; Tobe, Sheldon W.; Auguste, Bourne L. title: An Interprofessional Approach in Caring for a Patient on Maintenance Hemodialysis with COVID-19 in Toronto, Canada: An Educational Case Report date: 2020-09-08 journal: Can J Kidney Health Dis DOI: 10.1177/2054358120957473 sha: doc_id: 350200 cord_uid: 1w5u3w8i file: cache/cord-351223-nnuoadh6.json key: cord-351223-nnuoadh6 authors: Pettit, Natasha N.; MacKenzie, Erica L.; Ridgway, Jessica; Pursell, Kenneth; Ash, Daniel; Patel, Bhakti; Pho, Mai T. title: Obesity is Associated with Increased Risk for Mortality Among Hospitalized Patients with COVID‐19 date: 2020-06-26 journal: Obesity (Silver Spring) DOI: 10.1002/oby.22941 sha: doc_id: 351223 cord_uid: nnuoadh6 file: cache/cord-350923-532lnnll.json key: cord-350923-532lnnll authors: Ramalho, Renata; Rao, Martin; Zhang, Chao; Agrati, Chiara; Ippolito, Giuseppe; Wang, Fu-Sheng; Zumla, Alimuddin; Maeurer, Markus title: Immunometabolism: new insights and lessons from antigen-directed cellular immune responses date: 2020-06-09 journal: Semin Immunopathol DOI: 10.1007/s00281-020-00798-w sha: doc_id: 350923 cord_uid: 532lnnll file: cache/cord-351184-kcc3p3ow.json key: cord-351184-kcc3p3ow authors: Dotters-Katz, Sarah K.; Hughes, Brenna L. title: Considerations for Obstetric Care during the COVID-19 Pandemic date: 2020-04-17 journal: Am J Perinatol DOI: 10.1055/s-0040-1710051 sha: doc_id: 351184 cord_uid: kcc3p3ow file: cache/cord-350578-wyz5jyjh.json key: cord-350578-wyz5jyjh authors: Bai, Li; Yang, Dawei; Wang, Xun; Tong, Lin; Zhu, Xiaodan; Zhong, Nanshan; Bai, Chunxue; Powell, Charles A.; Chen, Rongchang; Zhou, Jian; Song, Yuanlin; Zhou, Xin; Zhu, Huili; Han, Baohui; Li, Qiang; Shi, Guochao; Li, Shengqing; Wang, Changhui; Qiu, Zhongmin; Zhang, Yong; Xu, Yu; Liu, Jie; Zhang, Ding; Wu, Chaomin; Li, Jing; Yu, Jinming; Wang, Jiwei; Dong, Chunling; Wang, Yaoli; Wang, Qi; Zhang, Lichuan; Zhang, Min; Ma, Xia; Zhao, Lin; Yu, Wencheng; Xu, Tao; Jin, Yang; Wang, Xiongbiao; Wang, Yuehong; Jiang, Yan; Chen, Hong; Xiao, Kui; Zhang, Xiaoju; Song, Zhenju; Zhang, Ziqiang; Wu, Xueling; Sun, Jiayuan; Shen, Yao; Ye, Maosong; Tu, Chunlin; Jiang, Jinjun; Yu, Hai; Tan, Fei title: Chinese experts’ consensus on the Internet of Things-aided diagnosis and treatment of coronavirus disease 2019 (COVID-19) date: 2020-12-31 journal: Clinical eHealth DOI: 10.1016/j.ceh.2020.03.001 sha: doc_id: 350578 cord_uid: wyz5jyjh file: cache/cord-350639-iguadmw1.json key: cord-350639-iguadmw1 authors: Padlina, G; Bellwald, S; Maurer, A; Heldner, MR title: Secondary Cerebrovascular Prevention in Light of the COVID-19 Pandemic date: 2020-08-05 journal: Curr Treat Options Neurol DOI: 10.1007/s11940-020-00634-4 sha: doc_id: 350639 cord_uid: iguadmw1 file: cache/cord-351046-yq7287k9.json key: cord-351046-yq7287k9 authors: Schubert, Gena; Haverland, Josh; Wyst, Craig Vander; McGreevy, Jon title: How Much Drool Is Too Much?() date: 2019-12-13 journal: Clin Pediatr Emerg Med DOI: 10.1016/j.cpem.2019.100742 sha: doc_id: 351046 cord_uid: yq7287k9 file: cache/cord-350959-bsbz3a1l.json key: cord-350959-bsbz3a1l authors: Dovey, Zachary; Mohamed, Nihal; Gharib, Yasmine; Ratnani, Parita; Hammouda, Nada; Nair, Sujit; Chakravarty, Dimple; Stanislaw, Sobotka; Lantz, Anna; Wiklund, Peter; Kyprianou, Natasha; Tewari, Ash title: Impact of COVID-19 on Prostate Cancer Management: Guidelines for Urologists date: 2020-06-16 journal: nan DOI: 10.1016/j.euros.2020.05.005 sha: doc_id: 350959 cord_uid: bsbz3a1l file: cache/cord-351457-fzj3ciif.json key: cord-351457-fzj3ciif authors: Vezzoli, Pamela; Di Mercurio, Marco; Carugno, Andrea; Gambini, Daniele Mario; Robustelli Test, Elisa; Imberti, Gianlorenzo; Castagna, Angelo Francesco; Sena, Paolo title: Cutaneous lupus erythematosus patients in a high‐epidemic COVID‐19 area, Bergamo, Italy date: 2020-06-07 journal: Dermatol Ther DOI: 10.1111/dth.13776 sha: doc_id: 351457 cord_uid: fzj3ciif file: cache/cord-349408-2ser9zjc.json key: cord-349408-2ser9zjc authors: Iannuzzi, Nicholas P.; Lack, William D.; Gee, Albert O.; Chansky, Howard A. title: An Orthopaedic Department’s Response to the COVID-19 Health-Care Crisis: Indirect and Direct Actions with Thoughts for the Future date: 2020-05-05 journal: J Bone Joint Surg Am DOI: 10.2106/jbjs.20.00611 sha: doc_id: 349408 cord_uid: 2ser9zjc file: cache/cord-351129-lzzyn570.json key: cord-351129-lzzyn570 authors: Lee, Jae-Hyun; Lee, Youngsoo; Lee, Suh-Young; Van Bever, Hugo; Lou, Hongfei; Zhang, Luo; Park, Hae-Sim title: Management of Allergic Patients During the COVID-19 Pandemic in Asia date: 2020-06-15 journal: Allergy Asthma Immunol Res DOI: 10.4168/aair.2020.12.5.783 sha: doc_id: 351129 cord_uid: lzzyn570 file: cache/cord-350718-jzliir37.json key: cord-350718-jzliir37 authors: Madrazo-González, Z.; García-Barrasa, A.; Rodríguez-Lorenzo, L.; Rafecas-Renau, A.; Alonso-Fernández, G. title: Anemia and transfusion therapy: an update date: 2011-12-31 journal: Medicina Intensiva (English Edition) DOI: 10.1016/s2173-5727(11)70007-8 sha: doc_id: 350718 cord_uid: jzliir37 file: cache/cord-351340-7y19ystp.json key: cord-351340-7y19ystp authors: Rao, Gundu H. R. title: Coronavirus Disease and Acute Vascular Events date: 2020-07-31 journal: Clin Appl Thromb Hemost DOI: 10.1177/1076029620929091 sha: doc_id: 351340 cord_uid: 7y19ystp file: cache/cord-351155-5bvo66yb.json key: cord-351155-5bvo66yb authors: Kushner, Tatyana; Cafardi, John title: Chronic Liver Disease and COVID‐19: Alcohol Use Disorder/Alcohol‐Associated Liver Disease, Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Autoimmune Liver Disease, and Compensated Cirrhosis date: 2020-05-21 journal: Clin Liver Dis (Hoboken) DOI: 10.1002/cld.974 sha: doc_id: 351155 cord_uid: 5bvo66yb file: cache/cord-351528-23lbs8al.json key: cord-351528-23lbs8al authors: Zacharia, Brad E; Eichberg, Daniel G; Ivan, Michael E; Hanft, Simon; Boockvar, John A; Isildak, Huseyin; Mansouri, Alireza; Komotar, Ricardo J; D’Amico, Randy S title: Letter: Surgical Management of Brain Tumor Patients in the COVID-19 Era date: 2020-04-29 journal: Neurosurgery DOI: 10.1093/neuros/nyaa162 sha: doc_id: 351528 cord_uid: 23lbs8al file: cache/cord-351531-wo1ggmmn.json key: cord-351531-wo1ggmmn authors: Giustiniano, Enrico; Fazzari, Fabio; Bragato, Renato Maria; Curzi, Mirko; Cecconi, Maurizio title: Trans-thoracic Echocardiography in Prone Positioning COVID-19 Patients: a Small Case Series date: 2020-09-15 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00516-5 sha: doc_id: 351531 cord_uid: wo1ggmmn file: cache/cord-351020-wde3ki0k.json key: cord-351020-wde3ki0k authors: Allione, Attilio; Giamello, Jacopo Davide; Paglietta, Giulia; Bernardi, Sara; Cavalot, Giulia title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-21 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02373-5 sha: doc_id: 351020 cord_uid: wde3ki0k file: cache/cord-351625-1we9wi1g.json key: cord-351625-1we9wi1g authors: Han, Huan; Xu, Zaichao; Cheng, Xiaoming; Zhong, Youquan; Yuan, Li; Wang, Fubing; Li, Yan; Liu, Fang; Jiang, Yingan; Zhu, Chengliang; Xia, Yuchen title: Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients date: 2020-10-07 journal: mSphere DOI: 10.1128/msphere.00922-20 sha: doc_id: 351625 cord_uid: 1we9wi1g file: cache/cord-351825-fdog73g2.json key: cord-351825-fdog73g2 authors: Tsai, Cheng-Yu; Chang, Nai-Chien; Fang, Hsiu-Chen; Chen, Ying-Che; Lee, Su-Shin title: A Novel Non-contact Self-Injection-Locked Radar for Vital Sign Sensing and Body Movement Monitoring in COVID-19 Isolation Ward date: 2020-08-26 journal: J Med Syst DOI: 10.1007/s10916-020-01637-z sha: doc_id: 351825 cord_uid: fdog73g2 file: cache/cord-351555-hsgsuor2.json key: cord-351555-hsgsuor2 authors: Constantinou, Constantina; Kolokotroni, Ourania; Mosquera, Maria‐Cecilia; Heraclides, Alexandros; Demetriou, Christiana; Karayiannis, Peter; Quattrocchi, Annalisa; Charalambous, Andreas title: Developing a holistic contingency plan: Challenges and dilemmas for cancer patients during the COVID‐19 date: 2020-07-20 journal: Cancer Med DOI: 10.1002/cam4.3271 sha: doc_id: 351555 cord_uid: hsgsuor2 file: cache/cord-351896-j6h02ab5.json key: cord-351896-j6h02ab5 authors: Ghannam, Malik; Alshaer, Qasem; Al-Chalabi, Mustafa; Zakarna, Lara; Robertson, Jetter; Manousakis, Georgios title: Neurological involvement of coronavirus disease 2019: a systematic review date: 2020-06-19 journal: J Neurol DOI: 10.1007/s00415-020-09990-2 sha: doc_id: 351896 cord_uid: j6h02ab5 file: cache/cord-352193-izzqdg3v.json key: cord-352193-izzqdg3v authors: Allen, M.; Bhanji, A.; Willemsen, J.; Dudfield, S.; Logan, S.; Monks, T. title: Organising outpatient dialysis services during the COVID-19 pandemic. A simulation and mathematical modelling study. date: 2020-04-27 journal: nan DOI: 10.1101/2020.04.22.20075457 sha: doc_id: 352193 cord_uid: izzqdg3v file: cache/cord-351762-n95ar9ci.json key: cord-351762-n95ar9ci authors: Wang, Brian Xiangzhi title: Susceptibility and prognosis of COVID-19 patients with cardiovascular disease date: 2020-06-25 journal: Open Heart DOI: 10.1136/openhrt-2020-001310 sha: doc_id: 351762 cord_uid: n95ar9ci file: cache/cord-351776-otx5qwyu.json key: cord-351776-otx5qwyu authors: Ibáñez-Samaniego, Luis; Bighelli, Federico; Usón, Clara; Caravaca, Celia; Carrillo, Carlos Fernández; Romero, Miriam; Barreales, Mónica; Perelló, Christie; Madejón, Antonio; Marcos, Aránzazu Caballero; Albillos, Agustín; Fernández, Inmaculada; García-Samaniego, Javier; Calleja, José Luis; Bañares, Rafael title: Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19 date: 2020-06-21 journal: J Infect Dis DOI: 10.1093/infdis/jiaa355 sha: doc_id: 351776 cord_uid: otx5qwyu file: cache/cord-351604-x4rsdwqz.json key: cord-351604-x4rsdwqz authors: González-Gay, Miguel A.; Castañeda, Santos; Ancochea, Julio title: BioLogic THERAPY IN COVID-19 date: 2020-06-26 journal: Arch Bronconeumol DOI: 10.1016/j.arbres.2020.06.007 sha: doc_id: 351604 cord_uid: x4rsdwqz file: cache/cord-351722-3mw1te94.json key: cord-351722-3mw1te94 authors: Recalde, M.; Roel, E.; Pistillo, A.; Sena, A. G.; Prats-Uribe, A.; Ahmed, W. U.-R.; Alghoul, H.; Alshammari, T. M.; Alser, O.; Areia, C.; Burn, E.; Casajust, P.; Dawoud, D.; DuVall, S. L.; Falconer, T.; Fernandez-Bertolin, S.; Golozar, A.; Gong, M.; Lai, L. Y. H.; Lane, J. C. E.; Lynch, K. E.; Matheny, M. E.; Mehta, P. P.; Morales, D. R.; Natarjan, K.; Nyberg, F.; Posada, J. D.; Reich, C. G.; Schilling, L. M.; Shah, K.; Shah, N. H.; Subbian, V.; Zhang, L.; Zhu, H.; Ryan, P.; Prieto-Alhambra, D.; Kostka, K.; Duarte-Salles, T. title: Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom date: 2020-09-03 journal: nan DOI: 10.1101/2020.09.02.20185173 sha: doc_id: 351722 cord_uid: 3mw1te94 file: cache/cord-352065-960xqft4.json key: cord-352065-960xqft4 authors: Rello, Jordi; Belliato, Mirko; Dimopoulos, Meletios-Athanasios; Giamarellos-bourboulis, Evangelos J.; Jaksic, Vladimir; Martin-loeches, Ignacio; Mporas, Iosif; Pelosi, Paolo; Poulakou, Garyphallia; Pournaras, Spyridon; Tamae-kakazu, Maximiliano; Timsit, Jean-François; Waterer, Grant; Tejada, Sofia; Dimopoulos, George title: Update in COVID-19 in the Intensive Care Unit from the 2020 HELLENIC Athens International Symposium date: 2020-10-22 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.10.008 sha: doc_id: 352065 cord_uid: 960xqft4 file: cache/cord-352234-utjne1ef.json key: cord-352234-utjne1ef authors: Mendlovic, Joseph; Weiss, Gali; Da’as, Nael; Yinnon, Amos; Katz, David E. title: Internal medicine patients admitted without COVID‐19 during the outbreak date: 2020-08-11 journal: Int J Clin Pract DOI: 10.1111/ijcp.13630 sha: doc_id: 352234 cord_uid: utjne1ef file: cache/cord-351823-ldbscq4s.json key: cord-351823-ldbscq4s authors: Leung, Marco Shiu Tsun; Lin, Shangzhe George; Chow, Jason; Harky, Amer title: COVID‐19 and Oncology: Service transformation during pandemic date: 2020-08-18 journal: Cancer Med DOI: 10.1002/cam4.3384 sha: doc_id: 351823 cord_uid: ldbscq4s file: cache/cord-351735-x1lng449.json key: cord-351735-x1lng449 authors: Flikweert, Antine W.; Grootenboers, Marco J.J.H.; Yick, David C.Y.; du Mée, Arthur W.F.; van der Meer, Nardo J.M.; Rettig, Thijs C.D.; Kant, Merijn K.M. title: Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series date: 2020-07-08 journal: J Crit Care DOI: 10.1016/j.jcrc.2020.07.002 sha: doc_id: 351735 cord_uid: x1lng449 file: cache/cord-352401-tmt1pmw9.json key: cord-352401-tmt1pmw9 authors: Curatola, Antonietta; Ferretti, Serena; Gatto, Antonio; Chiaretti, Antonio title: Use of Handheld Transceiver for Hospital Healthcare Workers-Caregiver Communication During the Coronavirus disease 2019 (COVID-19) Outbreak in Pediatric Emergency Department date: 2020-04-13 journal: Pediatr Infect Dis J DOI: 10.1097/inf.0000000000002689 sha: doc_id: 352401 cord_uid: tmt1pmw9 file: cache/cord-352177-05sku8a8.json key: cord-352177-05sku8a8 authors: Pahus, Laurie; Suehs, Carey Meredith; Halimi, Laurence; Bourdin, Arnaud; Chanez, Pascal; Jaffuel, Dany; Marciano, Julie; Gamez, Anne-Sophie; Vachier, Isabelle; Molinari, Nicolas title: Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials? date: 2020-08-13 journal: BMC Med Ethics DOI: 10.1186/s12910-020-00509-y sha: doc_id: 352177 cord_uid: 05sku8a8 file: cache/cord-352302-are8vvhh.json key: cord-352302-are8vvhh authors: Hartman, W.; Hess, A. S.; Connor, J. P. title: Hospitalized COVID-19 patients treated with Convalescent Plasma in a mid-size city in the midwest date: 2020-06-22 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.06.19.20135830 sha: doc_id: 352302 cord_uid: are8vvhh file: cache/cord-352304-tt2q5mgs.json key: cord-352304-tt2q5mgs authors: Sun, Dan; Li, Hui; Lu, Xiao-Xia; Xiao, Han; Ren, Jie; Zhang, Fu-Rong; Liu, Zhi-Sheng title: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study date: 2020-03-19 journal: World J Pediatr DOI: 10.1007/s12519-020-00354-4 sha: doc_id: 352304 cord_uid: tt2q5mgs file: cache/cord-351819-ovpz36e7.json key: cord-351819-ovpz36e7 authors: Beyrouti, Rahma; Adams, Matthew E; Benjamin, Laura; Cohen, Hannah; Farmer, Simon F; Goh, Yee Yen; Humphries, Fiona; Jäger, Hans Rolf; Losseff, Nicholas A; Perry, Richard J; Shah, Sachit; Simister, Robert J; Turner, David; Chandratheva, Arvind; Werring, David J title: Characteristics of ischaemic stroke associated with COVID-19 date: 2020-04-30 journal: J Neurol Neurosurg Psychiatry DOI: 10.1136/jnnp-2020-323586 sha: doc_id: 351819 cord_uid: ovpz36e7 file: cache/cord-352159-qx16i7s1.json key: cord-352159-qx16i7s1 authors: Pettit, Natasha N.; Nguyen, Cynthia T.; Mutlu, Gökhan M; Wu, David; Kimmig, Lucas; Pitrak, David; Pursell, Kenneth title: Late Onset Infectious Complications and Safety of Tocilizumab in the Management of COVID‐19 date: 2020-08-13 journal: J Med Virol DOI: 10.1002/jmv.26429 sha: doc_id: 352159 cord_uid: qx16i7s1 file: cache/cord-351431-xcqz9d3t.json key: cord-351431-xcqz9d3t authors: Wang, Jun; Li, Qian; Yin, Yongmei; Zhang, Yingying; Cao, Yingying; Lin, Xiaoming; Huang, Lihua; Hoffmann, Daniel; Lu, Mengji; Qiu, Yuanwang title: Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19 date: 2020-08-18 journal: Front Immunol DOI: 10.3389/fimmu.2020.02063 sha: doc_id: 351431 cord_uid: xcqz9d3t file: cache/cord-352227-827987jf.json key: cord-352227-827987jf authors: Chernevskaya, Ekaterina; Beloborodova, Natalia; Klimenko, Natalia; Pautova, Alisa; Shilkin, Dmitrii; Gusarov, Vitaliy; Tyakht, Alexander title: Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study date: 2020-06-08 journal: Crit Care DOI: 10.1186/s13054-020-03031-0 sha: doc_id: 352227 cord_uid: 827987jf file: cache/cord-351597-bdazrbsz.json key: cord-351597-bdazrbsz authors: Thalappillil, Richard; White, Robert S.; Tam, Christopher W. title: POCUS to guide fluid-therapy in COVID-19 date: 2020-05-06 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.04.049 sha: doc_id: 351597 cord_uid: bdazrbsz file: cache/cord-352544-7b6btzrx.json key: cord-352544-7b6btzrx authors: Liu, Zhelong; Bai, Xi; Han, Xia; Jiang, Wangyan; Qiu, Lin; Chen, Shi; Yu, Xuefeng title: The association of diabetes and the prognosis of COVID-19 patients: a retrospective study date: 2020-08-25 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108386 sha: doc_id: 352544 cord_uid: 7b6btzrx file: cache/cord-352846-p7hhv297.json key: cord-352846-p7hhv297 authors: Bryson, Ethan O.; Aloysi, Amy Starr title: A strategy for management of ECT patients during the COVID-19 pandemic date: 2020-05-12 journal: J ECT DOI: 10.1097/yct.0000000000000702 sha: doc_id: 352846 cord_uid: p7hhv297 file: cache/cord-352215-dhkvh45t.json key: cord-352215-dhkvh45t authors: Ramachandran, Preethi; Perisetti, Abhilash; Gajendran, Mahesh; Chakraborti, Abhishek; Narh, Joshua Tetteh; Goyal, Hemant title: Increased serum aminotransferase activity and clinical outcomes in Coronavirus disease 2019 date: 2020-06-30 journal: J Clin Exp Hepatol DOI: 10.1016/j.jceh.2020.06.009 sha: doc_id: 352215 cord_uid: dhkvh45t file: cache/cord-352579-ndcbmgfj.json key: cord-352579-ndcbmgfj authors: Takahashi, Takuto; Luzum, Jasmine A.; Nicol, Melanie R.; Jacobson, Pamala A. title: Pharmacogenomics of COVID-19 therapies date: 2020-08-18 journal: NPJ Genom Med DOI: 10.1038/s41525-020-00143-y sha: doc_id: 352579 cord_uid: ndcbmgfj file: cache/cord-352828-4ecik6xw.json key: cord-352828-4ecik6xw authors: Lagziel, Tomer; Quiroga, Luis; Ramos, Margarita; Hultman, Charles S; Asif, Mohammed title: Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) date: 2020-05-19 journal: Cureus DOI: 10.7759/cureus.8198 sha: doc_id: 352828 cord_uid: 4ecik6xw file: cache/cord-352399-2xfzpw9m.json key: cord-352399-2xfzpw9m authors: Hearn, Jason; Pham, Quynh; Schwartz, Jeremy I.; Ssinabulya, Isaac; Akiteng, Ann R.; Ross, Heather J.; Cafazzo, Joseph A. title: Lived Experiences and Technological Literacy of Heart Failure Patients and Clinicians at a Cardiac Care Centre in Uganda date: 2020-07-28 journal: Annals of global health DOI: 10.5334/aogh.2905 sha: doc_id: 352399 cord_uid: 2xfzpw9m file: cache/cord-352823-1os3kwp1.json key: cord-352823-1os3kwp1 authors: Zeng, Hui; Li, Guoqing; Weng, Jian; Xiong, Ao; Xu, Chang; Yang, Yifei; Wang, Deli title: The strategies of perioperative management in orthopedic department during the pandemic of COVID-19 date: 2020-10-15 journal: J Orthop Surg Res DOI: 10.1186/s13018-020-01978-y sha: doc_id: 352823 cord_uid: 1os3kwp1 file: cache/cord-352901-ia34l2ml.json key: cord-352901-ia34l2ml authors: Natalello, Gerlando; De Luca, Giacomo; Gigante, Laura; Campochiaro, Corrado; De Lorenzis, Enrico; Verardi, Lucrezia; Paglionico, Annamaria; Petricca, Luca; Martone, Anna Maria; Calvisi, Stefania; Ripa, Marco; Cavalli, Giulio; Della-Torre, Emanuel; Tresoldi, Moreno; Landi, Francesco; Bosello, Silvia Laura; Gremese, Elisa; Dagna, Lorenzo title: Nailfold capillaroscopy findings in patients with coronavirus disease 19: Broadening the spectrum of covid-19 microvascular involvement() date: 2020-09-17 journal: Microvasc Res DOI: 10.1016/j.mvr.2020.104071 sha: doc_id: 352901 cord_uid: ia34l2ml file: cache/cord-352914-jccxzit1.json key: cord-352914-jccxzit1 authors: Sanz Herrero, Francisco; Puchades Gimeno, Francesc; Ortega García, Pilar; Ferrer Gómez, Carolina; Ocete Mochón, María Dolores; García Deltoro, Miguel title: Methylprednisolone added to tocilizumab reduces mortality in SARS‐CoV‐2 pneumonia: An observational study date: 2020-06-30 journal: J Intern Med DOI: 10.1111/joim.13145 sha: doc_id: 352914 cord_uid: jccxzit1 file: cache/cord-352557-l7sahv5t.json key: cord-352557-l7sahv5t authors: Takla, Michael; Jeevaratnam, Kamalan title: Chloroquine, hydroxychloroquine, and COVID-19: systematic review and narrative synthesis of efficacy and safety date: 2020-11-13 journal: Saudi Pharm J DOI: 10.1016/j.jsps.2020.11.003 sha: doc_id: 352557 cord_uid: l7sahv5t file: cache/cord-352577-h3652seb.json key: cord-352577-h3652seb authors: Kopić, Jasminka; Paradžik, Maja Tomić title: Expanding the Use of Noninvasive Ventilation During an Epidemic date: 2014-08-27 journal: Disaster Med Public Health Prep DOI: 10.1017/dmp.2014.71 sha: doc_id: 352577 cord_uid: h3652seb file: cache/cord-352969-rpt7xja6.json key: cord-352969-rpt7xja6 authors: Kataria, Ashish; Yakubu, Idris; Winstead, Ryan; Gowda, Madan; Gupta, Gaurav title: COVID-19 in Kidney Transplantation: Epidemiology, Management Considerations, and the Impact on Kidney Transplant Practice date: 2020-07-15 journal: Transplant Direct DOI: 10.1097/txd.0000000000001031 sha: doc_id: 352969 cord_uid: rpt7xja6 file: cache/cord-353013-7cx0gnum.json key: cord-353013-7cx0gnum authors: DENG, Pengbo; HU, Chengping; LI, Yuanyuan; CAO, Liming; YANG, Huaping; LI, Min; AN, Jian; JIANG, Juan; GU, Qihua title: Bronchial Fistula: Rare Complication of Treatment with Anlotinib date: 2020-10-20 journal: Zhongguo Fei Ai Za Zhi DOI: 10.3779/j.issn.1009-3419.2020.102.40 sha: doc_id: 353013 cord_uid: 7cx0gnum file: cache/cord-353059-39msyuxb.json key: cord-353059-39msyuxb authors: Chroboczek, T.; Lacoste, M.; Wackenheim, C.; Challan-Belval, T.; Amar, B.; Boisson, T.; Hubac, J.; Leduc, D.; Masse, C.; Dechaene, V.; Touhiri-Maximin, L.; Megessier, S.; Lassale, C. title: Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis. date: 2020-05-13 journal: nan DOI: 10.1101/2020.05.08.20094755 sha: doc_id: 353059 cord_uid: 39msyuxb file: cache/cord-353180-hbwrzm6s.json key: cord-353180-hbwrzm6s authors: Umoren, Rachel A.; Gray, Megan M.; Handley, Sarah; Johnson, Nathaniel; Kunimura, Christina; Mietzsch, Ulrike; Billimoria, Zeenia; Lo, Mark D. title: In-Hospital Telehealth Supports Care for Neonatal Patients in Strict Isolation date: 2020-04-08 journal: Am J Perinatol DOI: 10.1055/s-0040-1709687 sha: doc_id: 353180 cord_uid: hbwrzm6s file: cache/cord-352937-htmp0avc.json key: cord-352937-htmp0avc authors: Chow, Velda Ling Yu; Chan, Jimmy Yu Wai; Wong, Stanley Thian Sze; Wei, William Ignace title: Recommendations for surgical management of recurrent nasopharyngeal carcinoma during COVID‐19 pandemic date: 2020-06-13 journal: Laryngoscope Investig Otolaryngol DOI: 10.1002/lio2.417 sha: doc_id: 352937 cord_uid: htmp0avc file: cache/cord-352889-fl61z3w3.json key: cord-352889-fl61z3w3 authors: Downs, John B.; Weled, Barry; Räsänen, Jukka; Haines, Krista L.; Vidyasagar, Dharmapuri; Stock, M. Christine; Habashi, Nader title: Proposal for Coronavirus Disease 2019 Management date: 2020-05-12 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000127 sha: doc_id: 352889 cord_uid: fl61z3w3 file: cache/cord-352905-ge3u32hm.json key: cord-352905-ge3u32hm authors: Galimberti, Sara; Petrini, Mario; Baratè, Claudia; Ricci, Federica; Balducci, Serena; Grassi, Susanna; Guerrini, Francesca; Ciabatti, Elena; Mechelli, Sandra; Di Paolo, Antonello; Baldini, Chiara; Baglietto, Laura; Macera, Lisa; Spezia, Pietro Giorgio; Maggi, Fabrizio title: Tyrosine Kinase Inhibitors Play an Antiviral Action in Patients Affected by Chronic Myeloid Leukemia: A Possible Model Supporting Their Use in the Fight Against SARS-CoV-2 date: 2020-09-02 journal: Front Oncol DOI: 10.3389/fonc.2020.01428 sha: doc_id: 352905 cord_uid: ge3u32hm file: cache/cord-352678-8f2ygul2.json key: cord-352678-8f2ygul2 authors: Prasad, Ashish; Prasad, Manoj title: Single Virus Targeting Multiple Organs: What We Know and Where We Are Heading? date: 2020-08-05 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00370 sha: doc_id: 352678 cord_uid: 8f2ygul2 file: cache/cord-353256-7nfklun9.json key: cord-353256-7nfklun9 authors: Eroglu‐Ertugrul, Nesibe Gevher; Yalcin, Ebru; Oguz, Berna; Ocal, Turgay; Kuskonmaz, Baris; Emiralioglu, Nagehan; Dogru‐Ersoz, Deniz; Ozcelik, Ugur; Tezcan, Ilhan; Kiper, Nural title: The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children date: 2019-11-22 journal: Clin Respir J DOI: 10.1111/crj.13103 sha: doc_id: 353256 cord_uid: 7nfklun9 file: cache/cord-353281-leb7c7b0.json key: cord-353281-leb7c7b0 authors: Spiezia, Luca; Boscolo, Annalisa; Poletto, Francesco; Cerruti, Lorenzo; Tiberio, Ivo; Campello, Elena; Navalesi, Paolo; Simioni, Paolo title: COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure date: 2020-04-21 journal: Thromb Haemost DOI: 10.1055/s-0040-1710018 sha: doc_id: 353281 cord_uid: leb7c7b0 file: cache/cord-354127-sb8tovy2.json key: cord-354127-sb8tovy2 authors: de Abreu, Andrea Pio; Moura, José Andrade; Delfino, Vinicius Daher Alvares; Palma, Lilian Monteiro Pereira; do Nascimento, Marcelo Mazza title: Recommendations from the Brazilian Society of Nephrology regarding the use of cloth face coverings, by chronic kidney patients in dialysis, during the new coronavirus pandemic (Covid-19) date: 2020-08-26 journal: J Bras Nefrol DOI: 10.1590/2175-8239-jbn-2020-s103 sha: doc_id: 354127 cord_uid: sb8tovy2 file: cache/cord-353228-fxrf5wsp.json key: cord-353228-fxrf5wsp authors: Xiao, Yaru; Huang, Sufang; Yan, Li; Wang, Hui; Wang, Fang; Zhou, Ting; Deng, Juan; He, Mei title: Clinical characteristics of diarrhea in 90 cases with COVID-19: a descriptive study date: 2020-08-08 journal: Int Emerg Nurs DOI: 10.1016/j.ienj.2020.100912 sha: doc_id: 353228 cord_uid: fxrf5wsp file: cache/cord-353004-ocnp758o.json key: cord-353004-ocnp758o authors: Prakash, Lakshmanan; Dhar, Shabir Ahmed; Mushtaq, Muzaffar title: COVID-19 in the operating room: a review of evolving safety protocols date: 2020-07-20 journal: Patient Saf Surg DOI: 10.1186/s13037-020-00254-6 sha: doc_id: 353004 cord_uid: ocnp758o file: cache/cord-350571-6tapkjb6.json key: cord-350571-6tapkjb6 authors: nan title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 journal: Int J Clin Pharm DOI: 10.1007/s11096-016-0404-4 sha: doc_id: 350571 cord_uid: 6tapkjb6 file: cache/cord-353375-92pu0pp0.json key: cord-353375-92pu0pp0 authors: Hung, Jennifer C. H.; Li, Kenneth K. W. title: Implications of COVID-19 for uveitis patients: perspectives from Hong Kong date: 2020-04-29 journal: Eye (Lond) DOI: 10.1038/s41433-020-0905-1 sha: doc_id: 353375 cord_uid: 92pu0pp0 file: cache/cord-353200-5csewb1k.json key: cord-353200-5csewb1k authors: Jehi, Lara; Ji, Xinge; Milinovich, Alex; Erzurum, Serpil; Merlino, Amy; Gordon, Steve; Young, James B.; Kattan, Michael W. title: Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19 date: 2020-08-11 journal: PLoS One DOI: 10.1371/journal.pone.0237419 sha: doc_id: 353200 cord_uid: 5csewb1k file: cache/cord-353484-q7d0ysbo.json key: cord-353484-q7d0ysbo authors: Liu, Xue; Liu, Chao; Liu, Gang; Luo, Wenxin; Xia, Ningshao title: COVID-19: Progress in diagnostics, therapy and vaccination date: 2020-06-19 journal: Theranostics DOI: 10.7150/thno.47987 sha: doc_id: 353484 cord_uid: q7d0ysbo file: cache/cord-353648-rl9dts7l.json key: cord-353648-rl9dts7l authors: Kim, Hyun Joo; Ko, Justin Sangwook; Seo, Hyungseok; Kim, Tae-Yop title: Guidelines for the control and prevention of coronavirus disease (COVID-19) transmission in surgical and anesthetic settings date: 2020-05-12 journal: Korean J Anesthesiol DOI: 10.4097/kja.20235 sha: doc_id: 353648 cord_uid: rl9dts7l file: cache/cord-353671-xjpzhsup.json key: cord-353671-xjpzhsup authors: Sgouros, George; Bodei, Lisa; McDevitt, Michael R.; Nedrow, Jessie R. title: Radiopharmaceutical therapy in cancer: clinical advances and challenges date: 2020-07-29 journal: Nat Rev Drug Discov DOI: 10.1038/s41573-020-0073-9 sha: doc_id: 353671 cord_uid: xjpzhsup file: cache/cord-353956-gjv5cg3k.json key: cord-353956-gjv5cg3k authors: Bali, Rishi Kumar; Chaudhry, Kirti title: Maxillofacial surgery and COVID-19, The Pandemic !! date: 2020-04-11 journal: J Maxillofac Oral Surg DOI: 10.1007/s12663-020-01361-8 sha: doc_id: 353956 cord_uid: gjv5cg3k file: cache/cord-354223-0ckpz0bx.json key: cord-354223-0ckpz0bx authors: Yu, Pengming; Wei, Quan; He, Chengqi title: Early Rehabilitation for Critically Ill Patients With COVID-19: More Benefits Than Risks date: 2020-04-13 journal: Am J Phys Med Rehabil DOI: 10.1097/phm.0000000000001445 sha: doc_id: 354223 cord_uid: 0ckpz0bx file: cache/cord-354103-4dldgqzf.json key: cord-354103-4dldgqzf authors: Grubic, Andrew D; Ayazi, Shahin; Zebarjadi, Javad; Tahmasbi, Hamed; Ayazi, Khosro; Jobe, Blair A title: COVID-19 outbreak and surgical practice: The rationale for suspending non-urgent surgeries and role of testing modalities date: 2020-06-27 journal: World J Gastrointest Surg DOI: 10.4240/wjgs.v12.i6.259 sha: doc_id: 354103 cord_uid: 4dldgqzf file: cache/cord-353786-284qn075.json key: cord-353786-284qn075 authors: Chen, Zhi-Min; Fu, Jun-Fen; Shu, Qiang; Chen, Ying-Hu; Hua, Chun-Zhen; Li, Fu-Bang; Lin, Ru; Tang, Lan-Fang; Wang, Tian-Lin; Wang, Wei; Wang, Ying-Shuo; Xu, Wei-Ze; Yang, Zi-Hao; Ye, Sheng; Yuan, Tian-Ming; Zhang, Chen-Mei; Zhang, Yuan-Yuan title: Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus date: 2020-02-05 journal: World J Pediatr DOI: 10.1007/s12519-020-00345-5 sha: doc_id: 353786 cord_uid: 284qn075 file: cache/cord-353987-hj94a04i.json key: cord-353987-hj94a04i authors: Lehmann, L. H.; Totzeck, M. title: Establishing an oncocardiology service date: 2020-06-22 journal: Herz DOI: 10.1007/s00059-020-04952-w sha: doc_id: 353987 cord_uid: hj94a04i file: cache/cord-354372-vfvnjmv1.json key: cord-354372-vfvnjmv1 authors: Carpenito, L.; D'Ercole, M.; Porta, F.; Di Blasi, E.; Doi, P.; Fagara, G. Redolfi; Rey, R.; Bulfamante, G. title: The autopsy at the time of SARS-CoV-2: Protocol and lessons date: 2020-07-04 journal: Ann Diagn Pathol DOI: 10.1016/j.anndiagpath.2020.151562 sha: doc_id: 354372 cord_uid: vfvnjmv1 file: cache/cord-354160-sca9bgeq.json key: cord-354160-sca9bgeq authors: Al-Tawfiq, Jaffar A.; Al-Yami, Saeed S.; Rigamonti, Daniele title: Changes in Healthcare managing COVID and non-COVID-19 patients during the pandemic: Striking the balance date: 2020-08-13 journal: Diagnostic Microbiology and Infectious Disease DOI: 10.1016/j.diagmicrobio.2020.115147 sha: doc_id: 354160 cord_uid: sca9bgeq file: cache/cord-353340-l0icku0i.json key: cord-353340-l0icku0i authors: Olaoye, Omotayo; Tuck, Chloe; Khor, Wei Ping; McMenamin, Roisin; Hudson, Luke; Northall, Mike; Panford-Quainoo, Edwin; Asima, Derrick Mawuena; Ashiru-Oredope, Diane title: Improving Access to Antimicrobial Prescribing Guidelines in 4 African Countries: Development and Pilot Implementation of an App and Cross-Sectional Assessment of Attitudes and Behaviour Survey of Healthcare Workers and Patients date: 2020-08-29 journal: Antibiotics (Basel) DOI: 10.3390/antibiotics9090555 sha: doc_id: 353340 cord_uid: l0icku0i file: cache/cord-353293-vjdwh19x.json key: cord-353293-vjdwh19x authors: nan title: Post-COVID-19 global health strategies: the need for an interdisciplinary approach date: 2020-06-11 journal: Aging Clin Exp Res DOI: 10.1007/s40520-020-01616-x sha: doc_id: 353293 cord_uid: vjdwh19x file: cache/cord-353698-gj8sx3zy.json key: cord-353698-gj8sx3zy authors: Bibiano-Guillen, C.; Arias-Arcos, B.; Collado-Escudero, C.; Mir-Montero, M.; Corella-Montoya, F.; Torres-Macho, J.; Buendía-Garcia, M.J.; Larrainzar-Garijo, R. title: Adapted Diving Mask (ADM) device as respiratory support with oxygen output during COVID-19 pandemic date: 2020-10-28 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.10.043 sha: doc_id: 353698 cord_uid: gj8sx3zy file: cache/cord-353697-ocxextfj.json key: cord-353697-ocxextfj authors: Santana, Monique Freire; Pivoto, Guilherme; Alexandre, Márcia A. Araujo; Baía-da-Silva, Djane Clarys; Borba, Mayla Gabriela da Silva; Val, Fernando Almeida; Brito-Sousa, Jose Diego; Melo, Gisely Cardoso; Monteiro, Wuelton Marcelo; Souza, João Vicente Braga; Pinheiro, Silviane Bezerra; Ferreira, Luiz Carlos Lima; Naveca, Felipe Gomes; Nascimento, Valdinete Alves; Corado, André Lima Guerra; Hajjar, Ludhmila Abrahão; Silva, João Ricardo; Siva, George Alan Villarouco; Pasqualotto, Alessandro C.; Lacerda, Marcus Vinícius Guimarães title: Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management date: 2020-07-03 journal: Revista da Sociedade Brasileira de Medicina Tropical DOI: 10.1590/0037-8682-0401-2020 sha: doc_id: 353697 cord_uid: ocxextfj file: cache/cord-353401-y1mxnth7.json key: cord-353401-y1mxnth7 authors: Williams, Roger D.; Brundage, Jessica A.; Williams, Erin B. title: Moral Injury in Times of COVID-19 date: 2020-05-02 journal: J Health Serv Psychol DOI: 10.1007/s42843-020-00011-4 sha: doc_id: 353401 cord_uid: y1mxnth7 file: cache/cord-355003-1o2midnh.json key: cord-355003-1o2midnh authors: Wang, Min; Yang, Xiaohong; Yang, Fang; Zhu, Xinxin; Sun, Zhibing; Bao, Peiling; Yan, Yimin title: Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report date: 2020-09-04 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000021596 sha: doc_id: 355003 cord_uid: 1o2midnh file: cache/cord-354204-23xkug85.json key: cord-354204-23xkug85 authors: Smargiassi, Andrea; Soldati, Gino; Borghetti, Alberto; Scoppettuolo, Giancarlo; Tamburrini, Enrica; Testa, Antonia Carla; Moro, Francesca; Natale, Luigi; Larici, Anna Rita; Buonsenso, Danilo; Valentini, Piero; Draisci, Gaetano; Zanfini, Bruno Antonio; Pompili, Maurizio; Scambia, Giovanni; Lanzone, Antonio; Franceschi, Francesco; Rapaccini, Gian Ludovico; Gasbarrini, Antonio; Giorgini, Paolo; Richeldi, Luca; Demi, Libertario; Inchingolo, Riccardo title: Lung ultrasonography for early management of patients with respiratory symptoms during COVID-19 pandemic date: 2020-07-07 journal: J Ultrasound DOI: 10.1007/s40477-020-00501-7 sha: doc_id: 354204 cord_uid: 23xkug85 file: cache/cord-353594-z1vxamvp.json key: cord-353594-z1vxamvp authors: Gagiannis, Daniel; Steinestel, Julie; Hackenbroch, Carsten; Schreiner, Benno; Hannemann, Michael; Bloch, Wilhelm; Umathum, Vincent G.; Gebauer, Niklas; Rother, Conn; Stahl, Marcel; Witte, Hanno M.; Steinestel, Konrad title: Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD) date: 2020-10-02 journal: Front Immunol DOI: 10.3389/fimmu.2020.587517 sha: doc_id: 353594 cord_uid: z1vxamvp file: cache/cord-354373-lldfoptb.json key: cord-354373-lldfoptb authors: Chi, Jeffrey; Chitty, David; Lee, Meeyoung; Hakim, Nausheen; Lakhani, Shamsah; Rajdev, Lakshmi; Zhu, Xinhua; Saif, Muhammad Wasif title: COVID-19 Clinical Research date: 2020-05-05 journal: J Cell Signal DOI: 10.33696/signaling.1.006 sha: doc_id: 354373 cord_uid: lldfoptb file: cache/cord-353599-cw29edwr.json key: cord-353599-cw29edwr authors: Kelleni, Mina T. title: Early use of Non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes date: 2020-11-04 journal: Biomed Pharmacother DOI: 10.1016/j.biopha.2020.110982 sha: doc_id: 353599 cord_uid: cw29edwr file: cache/cord-354619-pftjhtpo.json key: cord-354619-pftjhtpo authors: Farronato, Marco; Tadakamadla, Santosh K; Ali Quadri, Mir Faeq; Acharya, Shashidhar; Tadakamadla, Jyothi; Love, Robert M.; Jamal, Mohamed; Mulder, Riaan; Maspero, Cinzia; Farronato, Davide; Ivanov, Alexander; Neefs, Dirk; Cagetti, Maria Grazia; de Vito, Danila; Gupta, Rishi J.; Connelly, Stephen Thaddeus; Tartaglia, Gianluca M. title: A Call for Action to Safely Deliver Oral Health Care during and Post COVID-19 Pandemic date: 2020-09-15 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17186704 sha: doc_id: 354619 cord_uid: pftjhtpo file: cache/cord-354658-v451z3jq.json key: cord-354658-v451z3jq authors: Rajagopal, Keshava; Keller, Steven P.; Akkanti, Bindu; Bime, Christian; Loyalka, Pranav; Cheema, Faisal H.; Zwischenberger, Joseph B.; El Banayosy, Aly; Pappalardo, Federico; Slaughter, Mark S.; Slepian, Marvin J. title: Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date: 2020-05-11 journal: ASAIO J DOI: 10.1097/mat.0000000000001180 sha: doc_id: 354658 cord_uid: v451z3jq file: cache/cord-354194-hf5ndv5f.json key: cord-354194-hf5ndv5f authors: Cook, Mackenzie; Zonies, David; Brasel, Karen title: Prioritizing Communication in the Provision of Palliative Care for the Trauma Patient date: 2020-10-29 journal: Curr Trauma Rep DOI: 10.1007/s40719-020-00201-x sha: doc_id: 354194 cord_uid: hf5ndv5f file: cache/cord-354597-xubsodnk.json key: cord-354597-xubsodnk authors: Carvalho, Alexandre; Alqusairi, Rana; Adams, Anna; Paul, Michelle; Kothari, Neelay; Peters, Stevany; DeBenedet, Anthony T. title: SARS-CoV-2 Gastrointestinal Infection Causing Hemorrhagic Colitis: Implications for Detection and Transmission of COVID-19 Disease date: 2020-04-17 journal: Am J Gastroenterol DOI: 10.14309/ajg.0000000000000667 sha: doc_id: 354597 cord_uid: xubsodnk file: cache/cord-354411-4emzxu09.json key: cord-354411-4emzxu09 authors: Nouvenne, Antonio; Zani, Marco Davìd; Milanese, Gianluca; Parise, Alberto; Baciarello, Marco; Bignami, Elena Giovanna; Odone, Anna; Sverzellati, Nicola; Meschi, Tiziana; Ticinesi, Andrea title: Lung Ultrasound in COVID-19 Pneumonia: Correlations with Chest CT on Hospital admission date: 2020-06-22 journal: Respiration DOI: 10.1159/000509223 sha: doc_id: 354411 cord_uid: 4emzxu09 file: cache/cord-354168-omen8vvq.json key: cord-354168-omen8vvq authors: Al Saleh, Abdullah S.; Sher, Taimur; Gertz, Morie A. title: Multiple Myeloma in the Time of COVID-19 date: 2020-04-17 journal: Acta Haematol DOI: 10.1159/000507690 sha: doc_id: 354168 cord_uid: omen8vvq file: cache/cord-354720-fu19u2b0.json key: cord-354720-fu19u2b0 authors: White-Dzuro, Gabrielle; Gibson, Lauren E.; Zazzeron, Luca; White-Dzuro, Colin; Sullivan, Zachary; Diiorio, Daren A.; Low, Sarah A.; Chang, Marvin G.; Bittner, Edward A. title: Multisystem effects of COVID-19: a concise review for practitioners date: 2020-11-04 journal: Postgraduate medicine DOI: 10.1080/00325481.2020.1823094 sha: doc_id: 354720 cord_uid: fu19u2b0 file: cache/cord-353824-0oyvia6d.json key: cord-353824-0oyvia6d authors: Farooque, Umar; Shabih, Sohaib; Karimi, Sundas; Lohano, Ashok Kumar; Kataria, Saurabh title: Coronavirus Disease 2019-Related Acute Ischemic Stroke: A Case Report date: 2020-09-08 journal: Cureus DOI: 10.7759/cureus.10310 sha: doc_id: 353824 cord_uid: 0oyvia6d file: cache/cord-354689-dsv63it1.json key: cord-354689-dsv63it1 authors: Chen, Qian; Yang, Min; Liao, Guang-quan; Zhao, Yu-er; Yue, Dao-yuan; Yuan, Yue; Cheng, Bin; Qin, Hua title: Precautionary Measures: Performing ERCP on a Patient With Juxtapapillary Duodenal Diverticula (JPDD)-Related Biliary Stone After COVID-19 Lockdown Restriction Lifted in Wuhan, China date: 2020-09-04 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00564 sha: doc_id: 354689 cord_uid: dsv63it1 file: cache/cord-354216-4khdcjed.json key: cord-354216-4khdcjed authors: Sultan, Shahnaz; Altayar, Osama; Siddique, Shazia M.; Davitkov, Perica; Feuerstein, Joseph D.; Lim, Joseph K.; Falck-Ytter, Yngve; El-Serag, Hashem B. title: AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19 date: 2020-05-11 journal: Gastroenterology DOI: 10.1053/j.gastro.2020.05.001 sha: doc_id: 354216 cord_uid: 4khdcjed file: cache/cord-355028-1x7w1749.json key: cord-355028-1x7w1749 authors: Piazza, Cesare; Filauro, Marta; Dikkers, Frederik G.; Nouraei, S. A. Reza; Sandu, Kishore; Sittel, Christian; Amin, Milan R.; Campos, Guillermo; Eckel, Hans E.; Peretti, Giorgio title: Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society date: 2020-06-06 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06112-6 sha: doc_id: 355028 cord_uid: 1x7w1749 file: cache/cord-355039-qi4fwqbc.json key: cord-355039-qi4fwqbc authors: Azar, William S.; Njeim, Rachel; Fares, Angie H.; Azar, Nadim S.; Azar, Sami T.; El Sayed, Mazen; Eid, Assaad A. title: COVID-19 and diabetes mellitus: how one pandemic worsens the other date: 2020-08-02 journal: Rev Endocr Metab Disord DOI: 10.1007/s11154-020-09573-6 sha: doc_id: 355039 cord_uid: qi4fwqbc file: cache/cord-354337-a70avg2x.json key: cord-354337-a70avg2x authors: Mehraeen, Esmaeil; SeyedAlinaghi, SeyedAhmad; Nowroozi, Ali; Dadras, Omid; Alilou, Sanam; Shobeiri, Parnian; Behnezhad, Farzane; Karimi, Amirali title: A systematic review of ECG findings in patients with COVID-19 date: 2020-11-13 journal: Indian Heart J DOI: 10.1016/j.ihj.2020.11.007 sha: doc_id: 354337 cord_uid: a70avg2x file: cache/cord-354749-zkgb16ae.json key: cord-354749-zkgb16ae authors: Chen, Gang; Zhou, Yangzhong; Zhang, Lei; Wang, Ying; Hu, Rong-rong; Zhao, Xue; Song, Dan; Xia, Jing-hua; Qin, Yan; Chen, Li-meng; Li, Xue-mei title: Core principles for infection prevention in hemodialysis centers during the COVID-19 pandemic date: 2020-04-06 journal: Infection control and hospital epidemiology DOI: 10.1017/ice.2020.109 sha: doc_id: 354749 cord_uid: zkgb16ae file: cache/cord-355264-ygzh8von.json key: cord-355264-ygzh8von authors: Florez-Perdomo, William Andrés; Serrato-Vargas, Sergio Andrés; Bosque-Varela, Pilar; Moscote-Salazar, Luis Rafael; Joaquim, Andrei F.; Agrawal, Amit; Soto-Angel, Álvaro Ricardo; Tovar-Montenegro, Leidy Tatiana title: Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: a systematic review and meta-analysis date: 2020-08-25 journal: Clin Neurol Neurosurg DOI: 10.1016/j.clineuro.2020.106183 sha: doc_id: 355264 cord_uid: ygzh8von file: cache/cord-355533-5kgdg2nb.json key: cord-355533-5kgdg2nb authors: Kline, Jonathan D; Donovan, Andrew E title: Sentinel Case of COVID-19 at Fort Stewart, GA in a National Guard Soldier Participating in Annual Training: A Case Report date: 2020-06-22 journal: Mil Med DOI: 10.1093/milmed/usaa144 sha: doc_id: 355533 cord_uid: 5kgdg2nb file: cache/cord-355294-gifsqph6.json key: cord-355294-gifsqph6 authors: García-Suárez, Julio; de la Cruz, Javier; Cedillo, Ángel; Llamas, Pilar; Duarte, Rafael; Jiménez-Yuste, Víctor; Hernández-Rivas, José Ángel; Gil-Manso, Rodrigo; Kwon, Mi; Sánchez-Godoy, Pedro; Martínez-Barranco, Pilar; Colás-Lahuerta, Blanca; Herrera, Pilar; Benito-Parra, Laurentino; Alegre, Adrián; Velasco, Alberto; Matilla, Arturo; Aláez-Usón, María Concepción; Martos-Martínez, Rafael; Martínez-Chamorro, Carmen; Susana-Quiroz, Keina; Del Campo, Juan Francisco; de la Fuente, Adolfo; Herráez, Regina; Pascual, Adriana; Gómez, Elvira; Pérez-Oteyza, Jaime; Ruiz, Elena; Alonso, Arancha; González-Medina, José; Martín-Buitrago, Lucía Núñez; Canales, Miguel; González-Gascón, Isabel; Vicente-Ayuso, María Carmen; Valenciano, Susana; Roa, María García; Monteliu, Pablo Estival; López-Jiménez, Javier; Escobar, Cristián Escolano; Ortiz-Martín, Javier; Diez-Martin, José Luis; Martinez-Lopez, Joaquín title: Impact of hematologic malignancy and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study date: 2020-10-08 journal: J Hematol Oncol DOI: 10.1186/s13045-020-00970-7 sha: doc_id: 355294 cord_uid: gifsqph6 file: cache/cord-355524-qx396wq1.json key: cord-355524-qx396wq1 authors: Rao, P Vishnu; Tarigopula, Anil; Bansal, Nitin; Sethuraman, Nandini; Gopalakrishnan, Ram title: Clinical profile of respiratory viral infections: A study from tertiary care centre of South India date: 2017-09-30 journal: Indian Journal of Medical Specialities DOI: 10.1016/j.injms.2017.06.003 sha: doc_id: 355524 cord_uid: qx396wq1 file: cache/cord-355146-6rat5j64.json key: cord-355146-6rat5j64 authors: Whittemore, Paul; Macfarlane, Laura; Herbert, Anna; Farrant, John title: Use of awake proning to avoid invasive ventilation in a patient with severe COVID-19 pneumonitis date: 2020-08-03 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-236586 sha: doc_id: 355146 cord_uid: 6rat5j64 file: cache/cord-355528-y4a1g6km.json key: cord-355528-y4a1g6km authors: Balla, Mamtha; Merugu, Ganesh Prasad; Patel, Mitra; Koduri, Narayana Murty; Gayam, Vijay; Adapa, Sreedhar; Naramala, Srikanth; Konala, Venu Madhav title: COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective date: 2020-03-30 journal: J Clin Med Res DOI: 10.14740/jocmr4142 sha: doc_id: 355528 cord_uid: y4a1g6km file: cache/cord-354824-7fdcu2f0.json key: cord-354824-7fdcu2f0 authors: Wu, Renyi; Wang, Lujing; Kuo, Hsiao-Chen Dina; Shannar, Ahmad; Peter, Rebecca; Chou, Pochung Jordan; Li, Shanyi; Hudlikar, Rasika; Liu, Xia; Liu, Zhigang; Poiani, George J.; Amorosa, Louis; Brunetti, Luigi; Kong, Ah-Ng title: An Update on Current Therapeutic Drugs Treating COVID-19 date: 2020-05-11 journal: Curr Pharmacol Rep DOI: 10.1007/s40495-020-00216-7 sha: doc_id: 354824 cord_uid: 7fdcu2f0 file: cache/cord-355504-zsyvgm9c.json key: cord-355504-zsyvgm9c authors: Feng, Feng; Xia, Ganlin; Shi, Yuxin; Zhang, Zhiyong title: Longitudinal changes of pneumonia complicating novel influenza A (H1N1) by high-resolution computed tomography date: 2015-06-09 journal: Radiol Infect Dis DOI: 10.1016/j.jrid.2015.06.001 sha: doc_id: 355504 cord_uid: zsyvgm9c file: cache/cord-355898-hlkwwaqe.json key: cord-355898-hlkwwaqe authors: Grippo, Antonello; Assenza, Giovanni; Scarpino, Maenia; Broglia, Lidia; Cilea, Rosalia; Galimberti, Carlo Andrea; Lanzo, Giovanni; Michelucci, Roberto; Tassi, Laura; Vergari, Maurizio; Di Lazzaro, Vincenzo; Mecarelli, Oriano title: Electroencephalography during SARS-CoV-2 outbreak: practical recommendations from the task force of the Italian Society of Neurophysiology (SINC), the Italian League Against Epilepsy (LICE), and the Italian Association of Neurophysiology Technologists (AITN) date: 2020-07-21 journal: Neurol Sci DOI: 10.1007/s10072-020-04585-1 sha: doc_id: 355898 cord_uid: hlkwwaqe file: cache/cord-355031-l0tj7kp2.json key: cord-355031-l0tj7kp2 authors: Krenitsky, Nicole M.; Spiegelman, Jessica; Sutton, Desmond; Syeda, Sbaa; Moroz, Leslie title: Primed for a Pandemic: Implementation of Telehealth Outpatient Monitoring for Women with Mild COVID-19 date: 2020-07-21 journal: Semin Perinatol DOI: 10.1016/j.semperi.2020.151285 sha: doc_id: 355031 cord_uid: l0tj7kp2 file: cache/cord-355431-efwuy8p9.json key: cord-355431-efwuy8p9 authors: Ambrosio, Luca; Vadalà, Gianluca; Russo, Fabrizio; Papalia, Rocco; Denaro, Vincenzo title: The role of the orthopaedic surgeon in the COVID-19 era: cautions and perspectives date: 2020-05-27 journal: J Exp Orthop DOI: 10.1186/s40634-020-00255-5 sha: doc_id: 355431 cord_uid: efwuy8p9 file: cache/cord-355033-txxylmrw.json key: cord-355033-txxylmrw authors: frontera, Jennifer A.; Rahimian, Joseph O.; Yaghi, Shadi; Liu, Mengling; Lewis, Ariane; de Havenon, Adam; Mainali, Shraddha; Huang, Joshua; Scher, Erica; Wisniewski, Thomas; Troxel, Andrea B.; Meropol, Sharon; Balcer, Laura J.; Galetta, Steven L. title: Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study date: 2020-10-26 journal: Res Sq DOI: 10.21203/rs.3.rs-94509/v1 sha: doc_id: 355033 cord_uid: txxylmrw file: cache/cord-355191-jghvq3cy.json key: cord-355191-jghvq3cy authors: Yang, Yang; Zhao, Jun; Wu, Jian; Teng, Yi; Xia, Xinyi title: A Rare Case of Immune Thrombocytopenic Purpura Secondary to COVID‐19 date: 2020-05-22 journal: J Med Virol DOI: 10.1002/jmv.26051 sha: doc_id: 355191 cord_uid: jghvq3cy file: cache/cord-355190-ytdw1d5v.json key: cord-355190-ytdw1d5v authors: Mok, Chi Chiu; Ho, Ling Yin; Chan, Kar Li; Tse, Sau Mei; To, Chi Hung title: Trend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years date: 2020-09-11 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00552 sha: doc_id: 355190 cord_uid: ytdw1d5v file: cache/cord-355885-pg6mpuk5.json key: cord-355885-pg6mpuk5 authors: Saracoglu, Kemal T.; Saracoglu, Ayten; Demirhan, Recep title: Airway management strategies for the Covid 19 patients: A brief narrative review date: 2020-06-01 journal: J Clin Anesth DOI: 10.1016/j.jclinane.2020.109954 sha: doc_id: 355885 cord_uid: pg6mpuk5 file: cache/cord-355549-6xnjj5h5.json key: cord-355549-6xnjj5h5 authors: Cécile, Couchoud; Florian, Bayer; Carole, Ayav; Clémence, Béchade; Philippe, Brunet; François, Chantrel; Luc, Frimat; Roula, Galland; Maryvonne, Hourmant; Emmanuelle, Laurain; Thierry, Lobbedez; Lucile, Mercadal; Olivier, Moranne title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date: 2020-08-25 journal: Kidney Int DOI: 10.1016/j.kint.2020.07.042 sha: doc_id: 355549 cord_uid: 6xnjj5h5 file: cache/cord-355484-2igc5wzx.json key: cord-355484-2igc5wzx authors: Oteo, J. A.; Marco, P.; Ponce de Leon, L.; Roncero, A.; Lobera, T.; Lisa, V. title: A short therapeutic regimen based on hydroxychloroquine plus azithromycin for the treatment of COVID-19 in patients with non-severe disease. A strategy associated with a reduction in hospital admissions and complications. date: 2020-06-12 journal: nan DOI: 10.1101/2020.06.10.20101105 sha: doc_id: 355484 cord_uid: 2igc5wzx file: cache/cord-355384-qa7grviy.json key: cord-355384-qa7grviy authors: NaserEddin, Adeeb; Dinur-Schejter, Yael; Shadur, Bella; Zaidman, Irina; Even-Or, Ehud; Averbuch, Diana; Shamriz, Oded; Tal, Yuval; Shaag, Avraham; Warnatz, Klaus; Elpeleg, Orly; Stepensky, Polina title: Bacillus Calmette–Guerin (BCG) Vaccine-associated Complications in Immunodeficient Patients Following Stem Cell Transplantation date: 2020-10-27 journal: J Clin Immunol DOI: 10.1007/s10875-020-00892-6 sha: doc_id: 355384 cord_uid: qa7grviy file: cache/cord-355177-62v1qhia.json key: cord-355177-62v1qhia authors: Emery, Andrew Robert; Saniukovich, Olga; Lang, Angela Lu; Tannyhill, R. John; Wang, Jingping; Statement, AAOMS Disclosure title: A Novel Approach to Fiberoptic Intubation in COVID-19 Patients date: 2020-07-24 journal: J Oral Maxillofac Surg DOI: 10.1016/j.joms.2020.07.027 sha: doc_id: 355177 cord_uid: 62v1qhia file: cache/cord-355558-r6r1t47c.json key: cord-355558-r6r1t47c authors: Shenoy, Akhil; Ismaily, Mehwish; Bajaj, Mandeep title: Diabetes and covid-19: a global health challenge date: 2020-04-27 journal: BMJ Open Diabetes Res Care DOI: 10.1136/bmjdrc-2020-001450 sha: doc_id: 355558 cord_uid: r6r1t47c file: cache/cord-356040-qdpkidn8.json key: cord-356040-qdpkidn8 authors: Ghazawi, Feras M.; Lim, Megan; Dutz, Jan P.; Kirchhof, Mark G. title: Infection risk of dermatologic therapeutics during the COVID‐19 pandemic: an evidence‐based recalibration date: 2020-07-03 journal: Int J Dermatol DOI: 10.1111/ijd.15028 sha: doc_id: 356040 cord_uid: qdpkidn8 file: cache/cord-355296-46jf56nc.json key: cord-355296-46jf56nc authors: Goldstein, David P.; Ralph, Gilbert; de Almeida, John R.; Jethwa, Ashok R.; Irish, Jonathan; Chepeha, Douglas B.; Brown, Dale; Gullane, Patrick; Waldron, John; Aziza, Elana; Durkin, Lisa title: Tracheoesophageal voice prosthesis management in laryngectomy patients during the COVID-19 pandemic date: 2020-08-10 journal: J Otolaryngol Head Neck Surg DOI: 10.1186/s40463-020-00456-z sha: doc_id: 355296 cord_uid: 46jf56nc file: cache/cord-356195-5pcaxpp9.json key: cord-356195-5pcaxpp9 authors: Jothimani, Dinesh; Venugopal, Radhika; Abedin, Mohammed Forhad; Kaliamoorthy, Ilankumaran; Rela, Mohamed title: COVID-19 and Liver. date: 2020-06-15 journal: J Hepatol DOI: 10.1016/j.jhep.2020.06.006 sha: doc_id: 356195 cord_uid: 5pcaxpp9 file: cache/cord-356371-w9ejgzvu.json key: cord-356371-w9ejgzvu authors: Torres-González, JI; Arias-Rivera, S; Velasco-Sanz, T; Mateos, Dávila A; Planas Pascual, B; Zaragoza-García, I; Raurell-Torredà, M title: What has happened to care during the COVID-19 pandemic? date: 2020-07-28 journal: nan DOI: 10.1016/j.enfie.2020.07.001 sha: doc_id: 356371 cord_uid: w9ejgzvu file: cache/cord-356127-xy5tyd7t.json key: cord-356127-xy5tyd7t authors: Omidi, Negar; Forouzannia, Seyed Khalil; Poorhosseini, Hamidreza; Tafti, Seyed Hossein Ahmadi; Salehbeigi, Shahrzad; Lotfi‐Tokaldany, Masoumeh title: Prosthetic heart valves and the COVID‐19 pandemic era: What should we be concerned about? date: 2020-09-28 journal: J Card Surg DOI: 10.1111/jocs.14707 sha: doc_id: 356127 cord_uid: xy5tyd7t file: cache/cord-356332-t0ahmh0h.json key: cord-356332-t0ahmh0h authors: Elkattawy, Sherif; Alyacoub, Ramez; Noori, Muhammad Atif Masood; Talpur, Afrah; Khimani, Karim title: A Rare Complication of Myocardial Infarction: Ventricular Septal Defect date: 2020-08-13 journal: Cureus DOI: 10.7759/cureus.9725 sha: doc_id: 356332 cord_uid: t0ahmh0h file: cache/cord-356215-0nypfw48.json key: cord-356215-0nypfw48 authors: Hu, Xiaojing; Liu, Si; Wang, Bo; Xiong, Hui; Wang, Ping title: Management practices of emergency departments in general hospitals based on blockage of chain of infection during a COVID-19 epidemic date: 2020-09-18 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02499-6 sha: doc_id: 356215 cord_uid: 0nypfw48 file: cache/cord-356349-ey5vnddu.json key: cord-356349-ey5vnddu authors: Fusco, Francesco M; Schilling, Stefan; De Iaco, Giuseppina; Brodt, Hans-Reinhard; Brouqui, Philippe; Maltezou, Helena C; Bannister, Barbara; Gottschalk, René; Thomson, Gail; Puro, Vincenzo; Ippolito, Giuseppe title: Infection control management of patients with suspected highly infectious diseases in emergency departments: data from a survey in 41 facilities in 14 European countries date: 2012-01-28 journal: BMC Infect Dis DOI: 10.1186/1471-2334-12-27 sha: doc_id: 356349 cord_uid: ey5vnddu file: cache/cord-356379-e8ohc25w.json key: cord-356379-e8ohc25w authors: Wu, Qiuji; Chen, Tielong; Zhang, Hongyan title: Recovery from COVID‐19 in two patients with coexisted HIV infection date: 2020-05-13 journal: J Med Virol DOI: 10.1002/jmv.26006 sha: doc_id: 356379 cord_uid: e8ohc25w file: cache/cord-356056-82bvcuvd.json key: cord-356056-82bvcuvd authors: Shaikh, Aasef G.; Mitoma, Hiroshi; Manto, Mario title: Cerebellar Scholars’ Challenging Time in COVID-19 Pandemia date: 2020-04-16 journal: Cerebellum DOI: 10.1007/s12311-020-01131-9 sha: doc_id: 356056 cord_uid: 82bvcuvd file: cache/cord-356084-621qzpqd.json key: cord-356084-621qzpqd authors: Qu, Jiuxin; Wu, Chi; Li, Xiaoyong; Zhang, Guobin; Jiang, Zhaofang; Li, Xiaohe; zhu, Qing; Liu, Lei title: Profile of IgG and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-04-27 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa489 sha: doc_id: 356084 cord_uid: 621qzpqd file: cache/cord-355589-3zdv9zim.json key: cord-355589-3zdv9zim authors: Simons, David; Shahab, Lion; Brown, Jamie; Perski, Olga title: The association of smoking status with SARS‐CoV‐2 infection, hospitalisation and mortality from COVID‐19: A living rapid evidence review with Bayesian meta‐analyses (version 7) date: 2020-10-02 journal: Addiction DOI: 10.1111/add.15276 sha: doc_id: 355589 cord_uid: 3zdv9zim file: cache/cord-356057-87kxlqdc.json key: cord-356057-87kxlqdc authors: Chagas, Aline Lopes; da Fonseca, Leonardo Gomes; Coelho, Fabricio Ferreira; Saud, Lisa Rodrigues da Cunha; Abadala, Edson; Andraus, Wellington; Fiore, Lucas; Moreira, Airton Mota; Menezes, Marcos Roberto; Carnevale, Francisco César; Tani, Claudia Megumi; Alencar, Regiane S.S.M; D'Albuquerque, Luiz Augusto Carneiro; Herman, Paulo; Carrilho, Flair José title: Management of Hepatocellular Carcinoma during the COVID-19 Pandemic - São Paulo Clínicas Liver Cancer Group Multidisciplinary Consensus Statement date: 2020-10-15 journal: Clinics (Sao Paulo) DOI: 10.6061/clinics/2020/e2192 sha: doc_id: 356057 cord_uid: 87kxlqdc file: cache/cord-356246-4p0ok1mc.json key: cord-356246-4p0ok1mc authors: Ammirati, Enrico; Travi, Giovanna; Orcese, Carloandrea; Sacco, Alice; Auricchio, Sara; Frigerio, Maria; Puoti, Massimo title: Heart-Kidney Transplanted patient affected by COVID-19 pneumonia treated with tocilizumab on top of immunosuppressive maintenance therapy date: 2020-07-17 journal: Int J Cardiol Heart Vasc DOI: 10.1016/j.ijcha.2020.100596 sha: doc_id: 356246 cord_uid: 4p0ok1mc file: cache/cord-355038-o2hr5mox.json key: cord-355038-o2hr5mox authors: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 journal: Ann Intensive Care DOI: 10.1186/s13613-020-0623-7 sha: doc_id: 355038 cord_uid: o2hr5mox Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-patient-cord === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18438 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 19206 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18105 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 19245 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-002782-mena480g author: Chen, Jiajia title: Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection date: 2017-12-08 pages: extension: .txt txt: ./txt/cord-002782-mena480g.txt cache: ./cache/cord-002782-mena480g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002782-mena480g.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-000001-ug7v899j author: Madani, Tariq A title: Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia date: 2001-07-04 pages: extension: .txt txt: ./txt/cord-000001-ug7v899j.txt cache: ./cache/cord-000001-ug7v899j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000001-ug7v899j.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-004379-91a7sgir author: Han, Nayoung title: Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews date: 2020-02-20 pages: extension: .txt txt: ./txt/cord-004379-91a7sgir.txt cache: ./cache/cord-004379-91a7sgir.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004379-91a7sgir.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-000716-fhm8abxp author: Wang, Hao title: Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics date: 2012-07-11 pages: extension: .txt txt: ./txt/cord-000716-fhm8abxp.txt cache: ./cache/cord-000716-fhm8abxp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000716-fhm8abxp.txt' === file2bib.sh === id: cord-000831-zwfxnd7r author: Bakhshayeshkaram, Mehrdad title: Imaging Findings in Patients With H1N1 Influenza A Infection date: 2011-12-25 pages: extension: .txt txt: ./txt/cord-000831-zwfxnd7r.txt cache: ./cache/cord-000831-zwfxnd7r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000831-zwfxnd7r.txt' === file2bib.sh === id: cord-000308-cxr1ul7q author: Cianchi, Giovanni title: Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date: 2011-01-11 pages: extension: .txt txt: ./txt/cord-000308-cxr1ul7q.txt cache: ./cache/cord-000308-cxr1ul7q.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-000308-cxr1ul7q.txt' === file2bib.sh === id: cord-003446-yp5d29fk author: Edwards, Michael title: An Uncommon Cause of Spontaneous Pneumomediastinum and Subcutaneous Emphysema date: 2017-02-03 pages: extension: .txt txt: ./txt/cord-003446-yp5d29fk.txt cache: ./cache/cord-003446-yp5d29fk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-003446-yp5d29fk.txt' === file2bib.sh === id: cord-001661-dj9bxhwb author: Kao, Kuo-Chin title: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy date: 2015-05-15 pages: extension: .txt txt: ./txt/cord-001661-dj9bxhwb.txt cache: ./cache/cord-001661-dj9bxhwb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-001661-dj9bxhwb.txt' === file2bib.sh === id: cord-000229-9fr0m92p author: Yun, Tae Jin title: Radiological and Clinical Characteristics of a Military Outbreak of Pandemic H1N1 2009 Influenza Virus Infection date: 2010-06-21 pages: extension: .txt txt: ./txt/cord-000229-9fr0m92p.txt cache: ./cache/cord-000229-9fr0m92p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000229-9fr0m92p.txt' === file2bib.sh === id: cord-000457-e50a0suk author: Rhim, Jung-Woo title: Epidemiological and clinical characteristics of childhood pandemic 2009 H1N1 virus infection: an observational cohort study date: 2011-08-24 pages: extension: .txt txt: ./txt/cord-000457-e50a0suk.txt cache: ./cache/cord-000457-e50a0suk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000457-e50a0suk.txt' === file2bib.sh === id: cord-003291-zuqx6ksy author: Tang, Pingping title: Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review date: 2018-11-03 pages: extension: .txt txt: ./txt/cord-003291-zuqx6ksy.txt cache: ./cache/cord-003291-zuqx6ksy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003291-zuqx6ksy.txt' === file2bib.sh === id: cord-002514-pp06m5xk author: Venkatesan, Sudhir title: Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis date: 2017-05-15 pages: extension: .txt txt: ./txt/cord-002514-pp06m5xk.txt cache: ./cache/cord-002514-pp06m5xk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-002514-pp06m5xk.txt' === file2bib.sh === id: cord-001322-7xmxcm35 author: Walden, Andrew P title: Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort date: 2014-04-01 pages: extension: .txt txt: ./txt/cord-001322-7xmxcm35.txt cache: ./cache/cord-001322-7xmxcm35.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001322-7xmxcm35.txt' === file2bib.sh === id: cord-004342-9uok77wb author: Lin, Chun-Yu title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date: 2020-02-14 pages: extension: .txt txt: ./txt/cord-004342-9uok77wb.txt cache: ./cache/cord-004342-9uok77wb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004342-9uok77wb.txt' === file2bib.sh === id: cord-001313-f72hl6du author: Toncheva, D. title: NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy date: 2014-05-15 pages: extension: .txt txt: ./txt/cord-001313-f72hl6du.txt cache: ./cache/cord-001313-f72hl6du.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001313-f72hl6du.txt' === file2bib.sh === id: cord-000284-00rk8fb5 author: Hajjar, L. A. title: Severe novel influenza A (H1N1) infection in cancer patients date: 2010-05-28 pages: extension: .txt txt: ./txt/cord-000284-00rk8fb5.txt cache: ./cache/cord-000284-00rk8fb5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000284-00rk8fb5.txt' === file2bib.sh === id: cord-001493-3yu2di1g author: Fujishima, Seitaro title: Pathophysiology and biomarkers of acute respiratory distress syndrome date: 2014-05-07 pages: extension: .txt txt: ./txt/cord-001493-3yu2di1g.txt cache: ./cache/cord-001493-3yu2di1g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001493-3yu2di1g.txt' === file2bib.sh === id: cord-000904-g6ffaer1 author: Ni, Hong title: Sorafenib Combined with Cryoablation to Treat Unresectable Hepatocellular Carcinoma date: 2011-09-17 pages: extension: .txt txt: ./txt/cord-000904-g6ffaer1.txt cache: ./cache/cord-000904-g6ffaer1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000904-g6ffaer1.txt' === file2bib.sh === id: cord-002145-yq7iwp42 author: Ibrahim, Ahmed title: Clinical profile and outcome of patients with acute kidney injury requiring dialysis—an experience from a haemodialysis unit in a developing country date: 2016-07-22 pages: extension: .txt txt: ./txt/cord-002145-yq7iwp42.txt cache: ./cache/cord-002145-yq7iwp42.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002145-yq7iwp42.txt' === file2bib.sh === id: cord-003533-8m0vyxq8 author: Jayathilaka, P. G. N. S. title: An outbreak of leptospirosis with predominant cardiac involvement: a case series date: 2019-03-18 pages: extension: .txt txt: ./txt/cord-003533-8m0vyxq8.txt cache: ./cache/cord-003533-8m0vyxq8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-003533-8m0vyxq8.txt' === file2bib.sh === id: cord-004310-hl7fa4af author: Matsuishi, Yujiro title: Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients date: 2020-02-10 pages: extension: .txt txt: ./txt/cord-004310-hl7fa4af.txt cache: ./cache/cord-004310-hl7fa4af.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-004310-hl7fa4af.txt' === file2bib.sh === id: cord-002294-qa8e90qv author: Hayakawa, Sho title: Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial date: 2016-11-07 pages: extension: .txt txt: ./txt/cord-002294-qa8e90qv.txt cache: ./cache/cord-002294-qa8e90qv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002294-qa8e90qv.txt' === file2bib.sh === id: cord-003404-eqgc8v7y author: May, Win Lai title: Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children date: 2019-01-02 pages: extension: .txt txt: ./txt/cord-003404-eqgc8v7y.txt cache: ./cache/cord-003404-eqgc8v7y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-003404-eqgc8v7y.txt' === file2bib.sh === id: cord-003520-f3jz59pt author: Arabi, Yaseen M. title: Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date: 2019-02-13 pages: extension: .txt txt: ./txt/cord-003520-f3jz59pt.txt cache: ./cache/cord-003520-f3jz59pt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003520-f3jz59pt.txt' === file2bib.sh === id: cord-002956-e5ihpe4i author: Chang, Ya-Chun title: Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure date: 2018-04-04 pages: extension: .txt txt: ./txt/cord-002956-e5ihpe4i.txt cache: ./cache/cord-002956-e5ihpe4i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-002956-e5ihpe4i.txt' === file2bib.sh === id: cord-002977-o0dvwzxk author: Gosangi, Babina title: Review of targeted therapy in chronic lymphocytic leukemia: what a radiologist needs to know about CT interpretation date: 2018-04-18 pages: extension: .txt txt: ./txt/cord-002977-o0dvwzxk.txt cache: ./cache/cord-002977-o0dvwzxk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002977-o0dvwzxk.txt' === file2bib.sh === id: cord-004404-s6udpwxq author: Seifi, Najmeh title: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies date: 2020-02-24 pages: extension: .txt txt: ./txt/cord-004404-s6udpwxq.txt cache: ./cache/cord-004404-s6udpwxq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-004404-s6udpwxq.txt' === file2bib.sh === id: cord-000161-hxjxczyr author: Rello, Jordi title: Clinical review: Primary influenza viral pneumonia date: 2009-12-21 pages: extension: .txt txt: ./txt/cord-000161-hxjxczyr.txt cache: ./cache/cord-000161-hxjxczyr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000161-hxjxczyr.txt' === file2bib.sh === id: cord-003798-nki2sasr author: Vidaur, Loreto title: Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis date: 2019-07-24 pages: extension: .txt txt: ./txt/cord-003798-nki2sasr.txt cache: ./cache/cord-003798-nki2sasr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003798-nki2sasr.txt' === file2bib.sh === id: cord-002853-vj8t28hn author: Joffe, Michael title: Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient date: 2018-01-27 pages: extension: .txt txt: ./txt/cord-002853-vj8t28hn.txt cache: ./cache/cord-002853-vj8t28hn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002853-vj8t28hn.txt' === file2bib.sh === id: cord-001421-6t5puo6p author: Marfà, Santiago title: Lack of a 5.9 kDa Peptide C-Terminal Fragment of Fibrinogen α Chain Precedes Fibrosis Progression in Patients with Liver Disease date: 2014-10-02 pages: extension: .txt txt: ./txt/cord-001421-6t5puo6p.txt cache: ./cache/cord-001421-6t5puo6p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001421-6t5puo6p.txt' === file2bib.sh === id: cord-002240-38aabxh1 author: Prina, Elena title: New aspects in the management of pneumonia date: 2016-10-01 pages: extension: .txt txt: ./txt/cord-002240-38aabxh1.txt cache: ./cache/cord-002240-38aabxh1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-002240-38aabxh1.txt' === file2bib.sh === id: cord-004147-9bcq3jnm author: Fernando, Shannon M. title: New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study date: 2020-01-13 pages: extension: .txt txt: ./txt/cord-004147-9bcq3jnm.txt cache: ./cache/cord-004147-9bcq3jnm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004147-9bcq3jnm.txt' === file2bib.sh === id: cord-001154-7k59ogn0 author: Memoli, Matthew J. title: The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts date: 2013-11-01 pages: extension: .txt txt: ./txt/cord-001154-7k59ogn0.txt cache: ./cache/cord-001154-7k59ogn0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001154-7k59ogn0.txt' === file2bib.sh === id: cord-001078-5m29nugu author: Chen, Xiaorong title: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study date: 2013-09-17 pages: extension: .txt txt: ./txt/cord-001078-5m29nugu.txt cache: ./cache/cord-001078-5m29nugu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-001078-5m29nugu.txt' === file2bib.sh === id: cord-005425-0hxow3sj author: Lekakis, L title: Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies date: 2006-08-07 pages: extension: .txt txt: ./txt/cord-005425-0hxow3sj.txt cache: ./cache/cord-005425-0hxow3sj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005425-0hxow3sj.txt' === file2bib.sh === id: cord-005452-ouookpd8 author: Ghosh, K title: Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation date: 1999-04-19 pages: extension: .txt txt: ./txt/cord-005452-ouookpd8.txt cache: ./cache/cord-005452-ouookpd8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005452-ouookpd8.txt' === file2bib.sh === id: cord-005819-fp5khzd5 author: Bonatz, K. title: Gram-negative bacterial pneumonia with secondary aspergillosis in an AIDS patient date: 1991 pages: extension: .txt txt: ./txt/cord-005819-fp5khzd5.txt cache: ./cache/cord-005819-fp5khzd5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005819-fp5khzd5.txt' === file2bib.sh === id: cord-003219-iryb3v0z author: Kao, Kuo-Chin title: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning date: 2018-09-24 pages: extension: .txt txt: ./txt/cord-003219-iryb3v0z.txt cache: ./cache/cord-003219-iryb3v0z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003219-iryb3v0z.txt' === file2bib.sh === id: cord-004263-m1ujhhsc author: Koekkoek, W. A. C. title: The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study date: 2020-02-03 pages: extension: .txt txt: ./txt/cord-004263-m1ujhhsc.txt cache: ./cache/cord-004263-m1ujhhsc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-004263-m1ujhhsc.txt' === file2bib.sh === id: cord-000268-480d3yfv author: Porfyridis, Ilias title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date: 2010-09-29 pages: extension: .txt txt: ./txt/cord-000268-480d3yfv.txt cache: ./cache/cord-000268-480d3yfv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000268-480d3yfv.txt' === file2bib.sh === id: cord-003011-vclnb0eh author: de Almeida, Carlos Podalirio Borges title: Predictors of In-Hospital Mortality among Patients with Pulmonary Tuberculosis: A Systematic Review and Meta-analysis date: 2018-05-08 pages: extension: .txt txt: ./txt/cord-003011-vclnb0eh.txt cache: ./cache/cord-003011-vclnb0eh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-003011-vclnb0eh.txt' === file2bib.sh === id: cord-003828-bhfghcby author: Zrzavy, Tobias title: Vaccination in Multiple Sclerosis: Friend or Foe? date: 2019-08-07 pages: extension: .txt txt: ./txt/cord-003828-bhfghcby.txt cache: ./cache/cord-003828-bhfghcby.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003828-bhfghcby.txt' === file2bib.sh === id: cord-005496-cnwg4dnn author: Gutierrez, Guillermo title: Artificial Intelligence in the Intensive Care Unit date: 2020-03-24 pages: extension: .txt txt: ./txt/cord-005496-cnwg4dnn.txt cache: ./cache/cord-005496-cnwg4dnn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-005496-cnwg4dnn.txt' === file2bib.sh === id: cord-003376-2qi4aibx author: van de Groep, Kirsten title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study date: 2018-12-18 pages: extension: .txt txt: ./txt/cord-003376-2qi4aibx.txt cache: ./cache/cord-003376-2qi4aibx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003376-2qi4aibx.txt' === file2bib.sh === id: cord-005697-l1zmrq4p author: Pène, Frédéric title: Is this critically ill patient immunocompromised? date: 2015-12-02 pages: extension: .txt txt: ./txt/cord-005697-l1zmrq4p.txt cache: ./cache/cord-005697-l1zmrq4p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005697-l1zmrq4p.txt' === file2bib.sh === id: cord-005420-60ie0pfd author: Sparrelid, E title: Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection date: 1998-10-09 pages: extension: .txt txt: ./txt/cord-005420-60ie0pfd.txt cache: ./cache/cord-005420-60ie0pfd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005420-60ie0pfd.txt' === file2bib.sh === id: cord-004986-en7taikk author: Nagy, Nathalie title: Infections gastro-intestinales chez le patient immunocompromis date: 2002 pages: extension: .txt txt: ./txt/cord-004986-en7taikk.txt cache: ./cache/cord-004986-en7taikk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004986-en7taikk.txt' === file2bib.sh === id: cord-004186-m817oudw author: Iwata, Shihoko title: Anesthetic management of a patient with a continuous-flow left ventricular assist device for video-assisted thoracoscopic surgery: a case report date: 2020-01-20 pages: extension: .txt txt: ./txt/cord-004186-m817oudw.txt cache: ./cache/cord-004186-m817oudw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-004186-m817oudw.txt' === file2bib.sh === id: cord-004643-uu4uipfy author: Hasan, Mohammad Rubayet title: Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report date: 2020-03-20 pages: extension: .txt txt: ./txt/cord-004643-uu4uipfy.txt cache: ./cache/cord-004643-uu4uipfy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004643-uu4uipfy.txt' === file2bib.sh === id: cord-001879-bn7h0kcw author: Papiris, Spyros A title: Survival in Idiopathic pulmonary fibrosis acute exacerbations: the non-steroid approach date: 2015-12-14 pages: extension: .txt txt: ./txt/cord-001879-bn7h0kcw.txt cache: ./cache/cord-001879-bn7h0kcw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001879-bn7h0kcw.txt' === file2bib.sh === id: cord-004096-obrq7q57 author: Benghanem, Sarah title: Brainstem dysfunction in critically ill patients date: 2020-01-06 pages: extension: .txt txt: ./txt/cord-004096-obrq7q57.txt cache: ./cache/cord-004096-obrq7q57.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004096-obrq7q57.txt' === file2bib.sh === id: cord-000891-5r2in1gw author: Giannella, Maddalena title: Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? date: 2012-06-14 pages: extension: .txt txt: ./txt/cord-000891-5r2in1gw.txt cache: ./cache/cord-000891-5r2in1gw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-000891-5r2in1gw.txt' === file2bib.sh === id: cord-004949-icsey27p author: Fernandez-Botran, Rafael title: Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia date: 2014-02-21 pages: extension: .txt txt: ./txt/cord-004949-icsey27p.txt cache: ./cache/cord-004949-icsey27p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004949-icsey27p.txt' === file2bib.sh === id: cord-001617-ff3j7i7i author: Siqueira, André M title: Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India date: 2015-03-20 pages: extension: .txt txt: ./txt/cord-001617-ff3j7i7i.txt cache: ./cache/cord-001617-ff3j7i7i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-001617-ff3j7i7i.txt' === file2bib.sh === id: cord-004464-nml9kqiu author: Lhommet, Claire title: Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation? date: 2020-03-06 pages: extension: .txt txt: ./txt/cord-004464-nml9kqiu.txt cache: ./cache/cord-004464-nml9kqiu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-004464-nml9kqiu.txt' === file2bib.sh === id: cord-003198-1kw5v6rm author: Vuillard, Constance title: Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study date: 2018-09-11 pages: extension: .txt txt: ./txt/cord-003198-1kw5v6rm.txt cache: ./cache/cord-003198-1kw5v6rm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003198-1kw5v6rm.txt' === file2bib.sh === id: cord-003701-i70ztypg author: Chow, Eric J. title: Influenza virus-related critical illness: prevention, diagnosis, treatment date: 2019-06-12 pages: extension: .txt txt: ./txt/cord-003701-i70ztypg.txt cache: ./cache/cord-003701-i70ztypg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003701-i70ztypg.txt' === file2bib.sh === id: cord-001293-dfaxj3bv author: Cavaillon, Jean-Marc title: Is boosting the immune system in sepsis appropriate? date: 2014-03-24 pages: extension: .txt txt: ./txt/cord-001293-dfaxj3bv.txt cache: ./cache/cord-001293-dfaxj3bv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001293-dfaxj3bv.txt' === file2bib.sh === id: cord-003832-q1422ydi author: Koyama, Kansuke title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors date: 2019-08-19 pages: extension: .txt txt: ./txt/cord-003832-q1422ydi.txt cache: ./cache/cord-003832-q1422ydi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-003832-q1422ydi.txt' === file2bib.sh === id: cord-006179-7uv4yfv2 author: Cheuk, Daniel Ka Leung title: Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children date: 2007-09-29 pages: extension: .txt txt: ./txt/cord-006179-7uv4yfv2.txt cache: ./cache/cord-006179-7uv4yfv2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006179-7uv4yfv2.txt' === file2bib.sh === id: cord-004314-gtwtakpr author: Holmen, Heidi title: Working with patients suffering from chronic diseases can be a balancing act for health care professionals - a meta-synthesis of qualitative studies date: 2020-02-10 pages: extension: .txt txt: ./txt/cord-004314-gtwtakpr.txt cache: ./cache/cord-004314-gtwtakpr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-004314-gtwtakpr.txt' === file2bib.sh === id: cord-004450-daxz9yhp author: Haeberle, Helene title: Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study date: 2020-03-04 pages: extension: .txt txt: ./txt/cord-004450-daxz9yhp.txt cache: ./cache/cord-004450-daxz9yhp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-004450-daxz9yhp.txt' === file2bib.sh === id: cord-005503-hm8tvkt3 author: Rasulo, Frank A. title: Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient date: 2020-03-24 pages: extension: .txt txt: ./txt/cord-005503-hm8tvkt3.txt cache: ./cache/cord-005503-hm8tvkt3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005503-hm8tvkt3.txt' === file2bib.sh === id: cord-006181-fkh2fzbr author: Bednarczyk, Joseph M. title: Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date: 2015-04-08 pages: extension: .txt txt: ./txt/cord-006181-fkh2fzbr.txt cache: ./cache/cord-006181-fkh2fzbr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006181-fkh2fzbr.txt' === file2bib.sh === id: cord-000522-d498qj2b author: Vincent, Jean-Louis title: Reducing mortality in sepsis: new directions date: 2002-12-05 pages: extension: .txt txt: ./txt/cord-000522-d498qj2b.txt cache: ./cache/cord-000522-d498qj2b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-000522-d498qj2b.txt' === file2bib.sh === id: cord-004636-t6qldq3s author: Saugel, Bernd title: Journal of Clinical Monitoring and Computing end of year summary 2019: hemodynamic monitoring and management date: 2020-03-14 pages: extension: .txt txt: ./txt/cord-004636-t6qldq3s.txt cache: ./cache/cord-004636-t6qldq3s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-004636-t6qldq3s.txt' === file2bib.sh === id: cord-004646-zhessjqh author: Bawazeer, Mohammed title: Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial date: 2020-03-20 pages: extension: .txt txt: ./txt/cord-004646-zhessjqh.txt cache: ./cache/cord-004646-zhessjqh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004646-zhessjqh.txt' === file2bib.sh === id: cord-003615-vpzzsdld author: Thompson, Kelly B. title: Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies date: 2019-04-24 pages: extension: .txt txt: ./txt/cord-003615-vpzzsdld.txt cache: ./cache/cord-003615-vpzzsdld.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003615-vpzzsdld.txt' === file2bib.sh === id: cord-005861-3k8h3euj author: Gravenstein, J. S. title: Safety in anesthesia date: 2014-03-17 pages: extension: .txt txt: ./txt/cord-005861-3k8h3euj.txt cache: ./cache/cord-005861-3k8h3euj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-005861-3k8h3euj.txt' === file2bib.sh === id: cord-004532-flo9139j author: Andrews, Peter title: Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis date: 2004-12-18 pages: extension: .txt txt: ./txt/cord-004532-flo9139j.txt cache: ./cache/cord-004532-flo9139j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004532-flo9139j.txt' === file2bib.sh === id: cord-005481-00rezmqj author: Reid, T title: Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial date: 2001-11-22 pages: extension: .txt txt: ./txt/cord-005481-00rezmqj.txt cache: ./cache/cord-005481-00rezmqj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005481-00rezmqj.txt' === file2bib.sh === id: cord-003686-1pfk4qve author: Kaneko, Naoe title: The role of interleukin-1 in general pathology date: 2019-06-06 pages: extension: .txt txt: ./txt/cord-003686-1pfk4qve.txt cache: ./cache/cord-003686-1pfk4qve.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003686-1pfk4qve.txt' === file2bib.sh === id: cord-006302-pnnkfid0 author: Ioakeimidou, A. title: Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction date: 2017-04-28 pages: extension: .txt txt: ./txt/cord-006302-pnnkfid0.txt cache: ./cache/cord-006302-pnnkfid0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006302-pnnkfid0.txt' === file2bib.sh === id: cord-005705-j765ruj1 author: Dreyfuss, Didier title: Is it better to consent to an RCT or to care?: Μηδεν αγαν (“nothing in excess”) date: 2004-12-17 pages: extension: .txt txt: ./txt/cord-005705-j765ruj1.txt cache: ./cache/cord-005705-j765ruj1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005705-j765ruj1.txt' === file2bib.sh === id: cord-004339-7nwpic3d author: Rennie, Katherine J. title: Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction date: 2020-02-13 pages: extension: .txt txt: ./txt/cord-004339-7nwpic3d.txt cache: ./cache/cord-004339-7nwpic3d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-004339-7nwpic3d.txt' === file2bib.sh === id: cord-001536-ta1i0ata author: Nair, Girish B title: Year in review 2013: critical care - respiratory infections date: 2014-10-29 pages: extension: .txt txt: ./txt/cord-001536-ta1i0ata.txt cache: ./cache/cord-001536-ta1i0ata.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001536-ta1i0ata.txt' === file2bib.sh === id: cord-006679-nhbofufv author: Lucarelli, G. title: Bone marrow transplantation for thalassemia date: 1993 pages: extension: .txt txt: ./txt/cord-006679-nhbofufv.txt cache: ./cache/cord-006679-nhbofufv.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-006679-nhbofufv.txt' === file2bib.sh === id: cord-006545-c12m75gq author: Pinilla, Inmaculada title: Radiological prognostic factors in patients with pandemic H1N1 (pH1N1) infection requiring hospital admission date: 2011-05-27 pages: extension: .txt txt: ./txt/cord-006545-c12m75gq.txt cache: ./cache/cord-006545-c12m75gq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006545-c12m75gq.txt' === file2bib.sh === id: cord-006621-0fxpn7qf author: Cantwell, Tamara title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date: 2017-10-10 pages: extension: .txt txt: ./txt/cord-006621-0fxpn7qf.txt cache: ./cache/cord-006621-0fxpn7qf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006621-0fxpn7qf.txt' === file2bib.sh === id: cord-005569-9d51l6bn author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia date: 2008-12-09 pages: extension: .txt txt: ./txt/cord-005569-9d51l6bn.txt cache: ./cache/cord-005569-9d51l6bn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005569-9d51l6bn.txt' === file2bib.sh === id: cord-005795-sgi54hq8 author: Ely, E. title: The impact of delirium in the intensive care unit on hospital length of stay date: 2001-11-08 pages: extension: .txt txt: ./txt/cord-005795-sgi54hq8.txt cache: ./cache/cord-005795-sgi54hq8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005795-sgi54hq8.txt' === file2bib.sh === id: cord-006544-yr4u61qv author: Miesbach, W. title: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation date: 2004-03-20 pages: extension: .txt txt: ./txt/cord-006544-yr4u61qv.txt cache: ./cache/cord-006544-yr4u61qv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006544-yr4u61qv.txt' === file2bib.sh === id: cord-006344-de4dhv4b author: Seitsonen, E. title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date: 2006-03-21 pages: extension: .txt txt: ./txt/cord-006344-de4dhv4b.txt cache: ./cache/cord-006344-de4dhv4b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006344-de4dhv4b.txt' === file2bib.sh === id: cord-006701-q8qh1kas author: Sadeghi, Behnam title: Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells date: 2019-12-18 pages: extension: .txt txt: ./txt/cord-006701-q8qh1kas.txt cache: ./cache/cord-006701-q8qh1kas.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006701-q8qh1kas.txt' === file2bib.sh === id: cord-005717-x7gsqlwp author: Hauser, Gabriel J. title: Pediatric intestinal and multivisceral transplantation: a new challenge for the pediatric intensivist date: 2008-05-24 pages: extension: .txt txt: ./txt/cord-005717-x7gsqlwp.txt cache: ./cache/cord-005717-x7gsqlwp.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005717-x7gsqlwp.txt' === file2bib.sh === id: cord-006841-3u56erru author: Einsele, Hermann title: Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) date: 2003-09-10 pages: extension: .txt txt: ./txt/cord-006841-3u56erru.txt cache: ./cache/cord-006841-3u56erru.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-006841-3u56erru.txt' === file2bib.sh === id: cord-006363-xov4xwpa author: Lu, Gen title: Study of Acute Exogenous Lipoid Pneumonia date: 2016-01-29 pages: extension: .txt txt: ./txt/cord-006363-xov4xwpa.txt cache: ./cache/cord-006363-xov4xwpa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006363-xov4xwpa.txt' === file2bib.sh === id: cord-005808-w0763esk author: Moreno, Gerard title: Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study date: 2018-08-03 pages: extension: .txt txt: ./txt/cord-005808-w0763esk.txt cache: ./cache/cord-005808-w0763esk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005808-w0763esk.txt' === file2bib.sh === id: cord-006714-q7wy76e2 author: Delannoy, P.-Y. title: Impact of combination therapy with aminoglycosides on the outcome of ICU-acquired bacteraemias date: 2012-02-15 pages: extension: .txt txt: ./txt/cord-006714-q7wy76e2.txt cache: ./cache/cord-006714-q7wy76e2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006714-q7wy76e2.txt' === file2bib.sh === id: cord-006000-ekwpkzqv author: Bewig, B. title: Eosinophilic alveolitis in BAL after lung transplantation date: 1999 pages: extension: .txt txt: ./txt/cord-006000-ekwpkzqv.txt cache: ./cache/cord-006000-ekwpkzqv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006000-ekwpkzqv.txt' === file2bib.sh === id: cord-006523-zxn4oqly author: Lodha, Rakesh title: Nosocomial infections in pediatric intensive care units date: 2001 pages: extension: .txt txt: ./txt/cord-006523-zxn4oqly.txt cache: ./cache/cord-006523-zxn4oqly.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006523-zxn4oqly.txt' === file2bib.sh === id: cord-006750-cg2i2bae author: Stoots, Sarah Abramson title: Clinical Insights into Diffuse Alveolar Hemorrhage in Antiphospholipid Syndrome date: 2019-09-06 pages: extension: .txt txt: ./txt/cord-006750-cg2i2bae.txt cache: ./cache/cord-006750-cg2i2bae.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006750-cg2i2bae.txt' === file2bib.sh === id: cord-006768-r2pa9qw0 author: Shobha, Vineeta title: Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India date: 2018-02-28 pages: extension: .txt txt: ./txt/cord-006768-r2pa9qw0.txt cache: ./cache/cord-006768-r2pa9qw0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006768-r2pa9qw0.txt' === file2bib.sh === id: cord-005692-n4vxazst author: Papazian, Laurent title: Ventilator-associated pneumonia in adults: a narrative review date: 2020-03-10 pages: extension: .txt txt: ./txt/cord-005692-n4vxazst.txt cache: ./cache/cord-005692-n4vxazst.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005692-n4vxazst.txt' === file2bib.sh === id: cord-006343-c0amee70 author: Martinez Rivera, Andrea title: Intestinal transplantation in children: current status date: 2016-03-31 pages: extension: .txt txt: ./txt/cord-006343-c0amee70.txt cache: ./cache/cord-006343-c0amee70.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006343-c0amee70.txt' === file2bib.sh === id: cord-007833-wkv808ix author: Modi, Dipenkumar title: Pomalidomide-Induced Pulmonary Toxicity in Multiple Myeloma date: 2015-12-16 pages: extension: .txt txt: ./txt/cord-007833-wkv808ix.txt cache: ./cache/cord-007833-wkv808ix.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-007833-wkv808ix.txt' === file2bib.sh === id: cord-006517-845w9r6l author: Lalueza, A. title: Impact of severe hematological abnormalities in the outcome of hospitalized patients with influenza virus infection date: 2017-05-13 pages: extension: .txt txt: ./txt/cord-006517-845w9r6l.txt cache: ./cache/cord-006517-845w9r6l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006517-845w9r6l.txt' === file2bib.sh === id: cord-006394-ucthbqvt author: Pawlik, Timothy M. title: Combined Resection and Radiofrequency Ablation for Advanced Hepatic Malignancies: Results in 172 Patients date: 2003 pages: extension: .txt txt: ./txt/cord-006394-ucthbqvt.txt cache: ./cache/cord-006394-ucthbqvt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006394-ucthbqvt.txt' === file2bib.sh === id: cord-006332-ikh45wuy author: Bengmark, Stig title: Nutritional Support to Prevent and Treat Multiple Organ Failure date: 1996 pages: extension: .txt txt: ./txt/cord-006332-ikh45wuy.txt cache: ./cache/cord-006332-ikh45wuy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006332-ikh45wuy.txt' === file2bib.sh === id: cord-007865-1oyl6clq author: Walsh, Paul title: Patients Would Prefer Ward to Emergency Department Boarding While Awaiting an Inpatient Bed date: 2008-02-21 pages: extension: .txt txt: ./txt/cord-007865-1oyl6clq.txt cache: ./cache/cord-007865-1oyl6clq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-007865-1oyl6clq.txt' === file2bib.sh === id: cord-007567-vst954ef author: Farquharson, Carolyn title: Responding to the severe acute respiratory syndrome (SARS) outbreak: Lessons learned in a Toronto emergency department() date: 2003-06-04 pages: extension: .txt txt: ./txt/cord-007567-vst954ef.txt cache: ./cache/cord-007567-vst954ef.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-007567-vst954ef.txt' === file2bib.sh === id: cord-006975-u5ecibta author: Haviland, Kelly title: Outcomes after long-term mechanical ventilation of cancer patients date: 2020-03-30 pages: extension: .txt txt: ./txt/cord-006975-u5ecibta.txt cache: ./cache/cord-006975-u5ecibta.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-006975-u5ecibta.txt' === file2bib.sh === id: cord-002626-jzwwses4 author: Kaul, Karen L. title: The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care date: 2017-07-16 pages: extension: .txt txt: ./txt/cord-002626-jzwwses4.txt cache: ./cache/cord-002626-jzwwses4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002626-jzwwses4.txt' === file2bib.sh === id: cord-007009-4wbvdg1r author: Takahashi, Toru title: The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan date: 2014-03-15 pages: extension: .txt txt: ./txt/cord-007009-4wbvdg1r.txt cache: ./cache/cord-007009-4wbvdg1r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007009-4wbvdg1r.txt' === file2bib.sh === id: cord-006464-s8rjoyse author: Bauer, Michael title: Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome date: 2015-02-27 pages: extension: .txt txt: ./txt/cord-006464-s8rjoyse.txt cache: ./cache/cord-006464-s8rjoyse.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006464-s8rjoyse.txt' === file2bib.sh === id: cord-007786-cu831tl7 author: Dondorp, Arjen M. title: Management of Severe Malaria and Severe Dengue in Resource-Limited Settings date: 2019-02-09 pages: extension: .txt txt: ./txt/cord-007786-cu831tl7.txt cache: ./cache/cord-007786-cu831tl7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007786-cu831tl7.txt' === file2bib.sh === id: cord-008672-luoxomif author: Mwachari, C. title: Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya date: 2004-10-29 pages: extension: .txt txt: ./txt/cord-008672-luoxomif.txt cache: ./cache/cord-008672-luoxomif.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-008672-luoxomif.txt' === file2bib.sh === id: cord-006518-al94gxjw author: Calder, Philip C. title: n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients date: 2004 pages: extension: .txt txt: ./txt/cord-006518-al94gxjw.txt cache: ./cache/cord-006518-al94gxjw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006518-al94gxjw.txt' === file2bib.sh === id: cord-006595-brpngt14 author: Pecchi, A. title: Radiologic imaging of the transplanted bowel date: 2005-03-04 pages: extension: .txt txt: ./txt/cord-006595-brpngt14.txt cache: ./cache/cord-006595-brpngt14.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006595-brpngt14.txt' === file2bib.sh === id: cord-007580-qwh8ei60 author: Knopf, Harry L.S. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 pages: extension: .txt txt: ./txt/cord-007580-qwh8ei60.txt cache: ./cache/cord-007580-qwh8ei60.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007580-qwh8ei60.txt' === file2bib.sh === id: cord-005750-54hul2lw author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea date: 2009-02-10 pages: extension: .txt txt: ./txt/cord-005750-54hul2lw.txt cache: ./cache/cord-005750-54hul2lw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005750-54hul2lw.txt' === file2bib.sh === id: cord-006563-qmigctkp author: nan title: The abstracts of the 26th congress of ESCTAIC, Timisoara, Romania, September 22–24 2016 date: 2017-03-07 pages: extension: .txt txt: ./txt/cord-006563-qmigctkp.txt cache: ./cache/cord-006563-qmigctkp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006563-qmigctkp.txt' === file2bib.sh === id: cord-008596-zhk82cor author: Watts, Clark title: Erosion of physician autonomy and public respect for the profession() date: 2008-07-09 pages: extension: .txt txt: ./txt/cord-008596-zhk82cor.txt cache: ./cache/cord-008596-zhk82cor.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-008596-zhk82cor.txt' === file2bib.sh === id: cord-009285-1ddfywfa author: Assicot, M. title: High serum procalcitonin concentrations in patients with sepsis and infection date: 1993-02-27 pages: extension: .txt txt: ./txt/cord-009285-1ddfywfa.txt cache: ./cache/cord-009285-1ddfywfa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009285-1ddfywfa.txt' === file2bib.sh === id: cord-006460-3ayc0hne author: Baue, Arthur E. title: Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients date: 2000-10-19 pages: extension: .txt txt: ./txt/cord-006460-3ayc0hne.txt cache: ./cache/cord-006460-3ayc0hne.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006460-3ayc0hne.txt' === file2bib.sh === id: cord-009891-gqrhbhbn author: Rassool, G. Hussein title: Current issues and forthcoming events date: 2003-09-03 pages: extension: .txt txt: ./txt/cord-009891-gqrhbhbn.txt cache: ./cache/cord-009891-gqrhbhbn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009891-gqrhbhbn.txt' === file2bib.sh === id: cord-006426-baf2d47y author: Kimura, Fumio title: Immunosuppression following surgical and traumatic injury date: 2010-08-26 pages: extension: .txt txt: ./txt/cord-006426-baf2d47y.txt cache: ./cache/cord-006426-baf2d47y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006426-baf2d47y.txt' === file2bib.sh === id: cord-007563-33jxxp1b author: nan title: Full Issue PDF date: 2018-06-25 pages: extension: .txt txt: ./txt/cord-007563-33jxxp1b.txt cache: ./cache/cord-007563-33jxxp1b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007563-33jxxp1b.txt' === file2bib.sh === id: cord-007444-c9vu8ako author: Sherk, Peter A. title: The Chronic Obstructive Pulmonary Disease Exacerbation date: 2000-12-01 pages: extension: .txt txt: ./txt/cord-007444-c9vu8ako.txt cache: ./cache/cord-007444-c9vu8ako.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-007444-c9vu8ako.txt' === file2bib.sh === id: cord-009360-rgwe2pkx author: Pilatz, Adrian title: High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval date: 2019-08-27 pages: extension: .txt txt: ./txt/cord-009360-rgwe2pkx.txt cache: ./cache/cord-009360-rgwe2pkx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-009360-rgwe2pkx.txt' === file2bib.sh === id: cord-009575-bd67ph64 author: Berr, C. title: Risk factors in multiple sclerosis: a population‐based case‐control study in Hautes‐Pyrénées, France date: 2009-01-29 pages: extension: .txt txt: ./txt/cord-009575-bd67ph64.txt cache: ./cache/cord-009575-bd67ph64.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009575-bd67ph64.txt' === file2bib.sh === id: cord-009322-7l7slziv author: Kraetsch, Hans-Georg title: Verlauf und prognostische Parameter bei Still-Syndrom des Erwachsenen: Eigene Erfahrungen und Literaturübersicht date: 1997 pages: extension: .txt txt: ./txt/cord-009322-7l7slziv.txt cache: ./cache/cord-009322-7l7slziv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009322-7l7slziv.txt' === file2bib.sh === id: cord-010487-wncgecld author: Rinella, Mary E. title: STELLAR 3 and STELLAR 4: Lessons From the Fall of Icarus date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-010487-wncgecld.txt cache: ./cache/cord-010487-wncgecld.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-010487-wncgecld.txt' === file2bib.sh === id: cord-010261-sy7esszi author: Tenenbein, Milton title: Early coagulopathy in severe iron poisoning date: 2006-08-17 pages: extension: .txt txt: ./txt/cord-010261-sy7esszi.txt cache: ./cache/cord-010261-sy7esszi.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010261-sy7esszi.txt' === file2bib.sh === id: cord-009697-dq4y89ab author: Yuen, Eddie title: Role of absolute lymphocyte count in the screening of patients with suspected SARS date: 2003-07-25 pages: extension: .txt txt: ./txt/cord-009697-dq4y89ab.txt cache: ./cache/cord-009697-dq4y89ab.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009697-dq4y89ab.txt' === file2bib.sh === id: cord-009278-98ebmd33 author: Ferreira-Coimbra, João title: Burden of Community-Acquired Pneumonia and Unmet Clinical Needs date: 2020-02-18 pages: extension: .txt txt: ./txt/cord-009278-98ebmd33.txt cache: ./cache/cord-009278-98ebmd33.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-009278-98ebmd33.txt' === file2bib.sh === id: cord-010658-67k8pthy author: Bernard, Andie title: PC-FACS May 2020 for July 2020 Issue date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-010658-67k8pthy.txt cache: ./cache/cord-010658-67k8pthy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010658-67k8pthy.txt' === file2bib.sh === id: cord-006236-2gpwf4z2 author: nan title: Abstracts from the First International Conference on Heart Failure in Children and Young Adults date: 2004 pages: extension: .txt txt: ./txt/cord-006236-2gpwf4z2.txt cache: ./cache/cord-006236-2gpwf4z2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006236-2gpwf4z2.txt' === file2bib.sh === id: cord-009982-zgbu46fo author: Cies, Jeffrey J. title: Peramivir for Influenza A and B Viral Infections: A Pharmacokinetic Case Series date: 2019-10-04 pages: extension: .txt txt: ./txt/cord-009982-zgbu46fo.txt cache: ./cache/cord-009982-zgbu46fo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009982-zgbu46fo.txt' === file2bib.sh === id: cord-007575-5ekgabx5 author: Luby, James P. title: Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses date: 2016-01-14 pages: extension: .txt txt: ./txt/cord-007575-5ekgabx5.txt cache: ./cache/cord-007575-5ekgabx5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007575-5ekgabx5.txt' === file2bib.sh === id: cord-010116-hfzs16jh author: Díaz‐Ravetllat, V. title: Significance of new lung infiltrates in outpatients after lung and heart–lung transplantation date: 2014-04-12 pages: extension: .txt txt: ./txt/cord-010116-hfzs16jh.txt cache: ./cache/cord-010116-hfzs16jh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-010116-hfzs16jh.txt' === file2bib.sh === id: cord-009507-l74c9x0n author: Singh, Amandeep title: Clinicopathological Conference: Fever, Productive Cough, and Tachycardia in a 22‐year‐old Asian Male date: 2008-01-08 pages: extension: .txt txt: ./txt/cord-009507-l74c9x0n.txt cache: ./cache/cord-009507-l74c9x0n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-009507-l74c9x0n.txt' === file2bib.sh === id: cord-011138-y9v5ivzg author: Hatchimonji, Justin S. title: Questioning dogma: does a GCS of 8 require intubation? date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-011138-y9v5ivzg.txt cache: ./cache/cord-011138-y9v5ivzg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-011138-y9v5ivzg.txt' === file2bib.sh === id: cord-005953-5z89yeb6 author: nan title: Abstracts des 114. Internistenkongresses 2008 date: 2008 pages: extension: .txt txt: ./txt/cord-005953-5z89yeb6.txt cache: ./cache/cord-005953-5z89yeb6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005953-5z89yeb6.txt' === file2bib.sh === id: cord-006882-t9w1cdr4 author: nan title: Royal Academy of Medicine in Ireland date: 2012-07-22 pages: extension: .txt txt: ./txt/cord-006882-t9w1cdr4.txt cache: ./cache/cord-006882-t9w1cdr4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006882-t9w1cdr4.txt' === file2bib.sh === id: cord-010856-3g0123lk author: Araghi, Ariyan S. title: An audit to analyse the two-week wait pathway at an oral cancer specialist district general hospital date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-010856-3g0123lk.txt cache: ./cache/cord-010856-3g0123lk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010856-3g0123lk.txt' === file2bib.sh === id: cord-010477-g754gjvh author: Carney, Kevin P. title: A Front-end Redesign With Implementation of a Novel “Intake” System to Improve Patient Flow in a Pediatric Emergency Department date: 2020-02-27 pages: extension: .txt txt: ./txt/cord-010477-g754gjvh.txt cache: ./cache/cord-010477-g754gjvh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010477-g754gjvh.txt' === file2bib.sh === id: cord-010844-y26y5myb author: Lessing, Noah L. title: Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why? date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-010844-y26y5myb.txt cache: ./cache/cord-010844-y26y5myb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-010844-y26y5myb.txt' === file2bib.sh === id: cord-007564-ljqrxjvv author: Leroy, O. title: 04 – Apport des explorations microbiologiques au diagnostic des infections des voies respiratoires basses date: 2006-11-13 pages: extension: .txt txt: ./txt/cord-007564-ljqrxjvv.txt cache: ./cache/cord-007564-ljqrxjvv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-007564-ljqrxjvv.txt' === file2bib.sh === id: cord-010461-un9pls28 author: Manohar, Sujal title: A Three-part Quality Improvement Initiative to Increase Patient Satisfaction and Reduce Appointment Time date: 2020-03-09 pages: extension: .txt txt: ./txt/cord-010461-un9pls28.txt cache: ./cache/cord-010461-un9pls28.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010461-un9pls28.txt' === file2bib.sh === id: cord-007788-09t52zix author: Wallhult, Elisabeth title: Early and Acute Complications and the Principles of HSCT Nursing Care date: 2017-11-22 pages: extension: .txt txt: ./txt/cord-007788-09t52zix.txt cache: ./cache/cord-007788-09t52zix.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-007788-09t52zix.txt' === file2bib.sh === id: cord-009788-bc6sc2rc author: Ferguson, J. K. title: Preventing healthcare‐associated infection: risks, healthcare systems and behaviour date: 2009-09-17 pages: extension: .txt txt: ./txt/cord-009788-bc6sc2rc.txt cache: ./cache/cord-009788-bc6sc2rc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009788-bc6sc2rc.txt' === file2bib.sh === id: cord-010036-6czkzek0 author: Lorentz, I T title: Treatment of idiopathic spasmodic torticollis with botulinum‐A toxin: a pilot study of 19 patients date: 1990-05-01 pages: extension: .txt txt: ./txt/cord-010036-6czkzek0.txt cache: ./cache/cord-010036-6czkzek0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010036-6czkzek0.txt' === file2bib.sh === id: cord-006508-rje9bnph author: Ballas, Samir K. title: Sickle Cell Anaemia: Progress in Pathogenesis and Treatment date: 2012-10-10 pages: extension: .txt txt: ./txt/cord-006508-rje9bnph.txt cache: ./cache/cord-006508-rje9bnph.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006508-rje9bnph.txt' === file2bib.sh === id: cord-010999-u2guhh3h author: Blackstone, Eric title: Making Medical Decisions for Incapacitated Patients Without Proxies: Part II date: 2019-11-06 pages: extension: .txt txt: ./txt/cord-010999-u2guhh3h.txt cache: ./cache/cord-010999-u2guhh3h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-010999-u2guhh3h.txt' === file2bib.sh === id: cord-002757-upwe0cpj author: Sullivan, Kathleen E. title: Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies date: 2017-08-07 pages: extension: .txt txt: ./txt/cord-002757-upwe0cpj.txt cache: ./cache/cord-002757-upwe0cpj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-002757-upwe0cpj.txt' === file2bib.sh === id: cord-011159-k2kca8zl author: Kamel, Toufik title: Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study date: 2020-01-07 pages: extension: .txt txt: ./txt/cord-011159-k2kca8zl.txt cache: ./cache/cord-011159-k2kca8zl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011159-k2kca8zl.txt' === file2bib.sh === id: cord-010416-u0yo0lk6 author: Tejada, Sofia title: Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-010416-u0yo0lk6.txt cache: ./cache/cord-010416-u0yo0lk6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-010416-u0yo0lk6.txt' === file2bib.sh === id: cord-010141-955r29sd author: Sibila, Oriol title: Nonantibiotic Adjunctive Therapies for Community-Acquired Pneumonia (Corticosteroids and Beyond): Where Are We with Them? date: 2016-12-17 pages: extension: .txt txt: ./txt/cord-010141-955r29sd.txt cache: ./cache/cord-010141-955r29sd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-010141-955r29sd.txt' === file2bib.sh === id: cord-007696-83v9yfa6 author: Zisman, David A. title: Pulmonary Fibrosis date: 2005 pages: extension: .txt txt: ./txt/cord-007696-83v9yfa6.txt cache: ./cache/cord-007696-83v9yfa6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-007696-83v9yfa6.txt' === file2bib.sh === id: cord-005992-mu917isy author: nan title: Abstracts der 49. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date: 2011-10-23 pages: extension: .txt txt: ./txt/cord-005992-mu917isy.txt cache: ./cache/cord-005992-mu917isy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005992-mu917isy.txt' === file2bib.sh === id: cord-010786-w3kjc6so author: Ghaderi, Sara title: Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway date: 2019-12-23 pages: extension: .txt txt: ./txt/cord-010786-w3kjc6so.txt cache: ./cache/cord-010786-w3kjc6so.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-010786-w3kjc6so.txt' === file2bib.sh === id: cord-010564-7c9h16bi author: Unolt, Marta title: Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition date: 2019-09-02 pages: extension: .txt txt: ./txt/cord-010564-7c9h16bi.txt cache: ./cache/cord-010564-7c9h16bi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-010564-7c9h16bi.txt' === file2bib.sh === id: cord-010460-pczs9alv author: Caruso, Thomas J. title: Retrospective Review of the Safety and Efficacy of Virtual Reality in a Pediatric Hospital date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-010460-pczs9alv.txt cache: ./cache/cord-010460-pczs9alv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010460-pczs9alv.txt' === file2bib.sh === id: cord-007818-jfp9uumb author: Papali, Alfred title: Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings date: 2019-02-09 pages: extension: .txt txt: ./txt/cord-007818-jfp9uumb.txt cache: ./cache/cord-007818-jfp9uumb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-007818-jfp9uumb.txt' === file2bib.sh === id: cord-007321-7gi6xrci author: Chow, Anthony W. title: Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections date: 1992-11-17 pages: extension: .txt txt: ./txt/cord-007321-7gi6xrci.txt cache: ./cache/cord-007321-7gi6xrci.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007321-7gi6xrci.txt' === file2bib.sh === id: cord-010566-tciwtxud author: Singh, Nina title: Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality date: 1998 pages: extension: .txt txt: ./txt/cord-010566-tciwtxud.txt cache: ./cache/cord-010566-tciwtxud.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-010566-tciwtxud.txt' === file2bib.sh === id: cord-009967-fyqc5bat author: Gleckman, Richard title: Cost‐Effective Antibiotic Prescribing date: 2012-01-24 pages: extension: .txt txt: ./txt/cord-009967-fyqc5bat.txt cache: ./cache/cord-009967-fyqc5bat.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009967-fyqc5bat.txt' === file2bib.sh === id: cord-011360-1n998win author: Zloto, Keren title: Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery date: 2019-11-15 pages: extension: .txt txt: ./txt/cord-011360-1n998win.txt cache: ./cache/cord-011360-1n998win.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011360-1n998win.txt' === file2bib.sh === id: cord-011533-im78xwl8 author: Gloude, Nicholas J. title: Thinking Beyond HLH: Clinical Features of Patients with Concurrent Presentation of Hemophagocytic Lymphohistiocytosis and Thrombotic Microangiopathy date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-011533-im78xwl8.txt cache: ./cache/cord-011533-im78xwl8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011533-im78xwl8.txt' === file2bib.sh === id: cord-011296-nutl2ovk author: Wu, Venus Kit Sze title: Prevalence, Clinical Characteristics, and Outcomes Related to Ventilator-Associated Events in Neurocritically Ill Patients date: 2020-01-23 pages: extension: .txt txt: ./txt/cord-011296-nutl2ovk.txt cache: ./cache/cord-011296-nutl2ovk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011296-nutl2ovk.txt' === file2bib.sh === id: cord-009667-8r8j0h08 author: Cao, Bin title: Diagnosis and treatment of community‐acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association date: 2017-09-26 pages: extension: .txt txt: ./txt/cord-009667-8r8j0h08.txt cache: ./cache/cord-009667-8r8j0h08.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-009667-8r8j0h08.txt' === file2bib.sh === id: cord-007577-f1jzbtjj author: Raphael Shulman, N. title: Hepatitis-associated antigen date: 2006-09-18 pages: extension: .txt txt: ./txt/cord-007577-f1jzbtjj.txt cache: ./cache/cord-007577-f1jzbtjj.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007577-f1jzbtjj.txt' === file2bib.sh === id: cord-005482-v5iayczy author: nan title: Publication Only date: 2016-03-21 pages: extension: .txt txt: ./txt/cord-005482-v5iayczy.txt cache: ./cache/cord-005482-v5iayczy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005482-v5iayczy.txt' === file2bib.sh === id: cord-012025-faj682bp author: Savioli, Felicio title: Coagulation profile in severe COVID-19 patients: what do we know so far? date: 2020 pages: extension: .txt txt: ./txt/cord-012025-faj682bp.txt cache: ./cache/cord-012025-faj682bp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-012025-faj682bp.txt' === file2bib.sh === id: cord-011255-9q2frk71 author: Kippnich, Maximilian title: Dual-room twin-CT scanner in multiple trauma care: first results after implementation in a level one trauma centre date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-011255-9q2frk71.txt cache: ./cache/cord-011255-9q2frk71.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011255-9q2frk71.txt' === file2bib.sh === id: cord-011349-bykvn367 author: Rajasekaran, Raja Bhaskara title: Megaprosthesis in distal femur nonunions in elderly patients—experience from twenty four cases date: 2019-08-07 pages: extension: .txt txt: ./txt/cord-011349-bykvn367.txt cache: ./cache/cord-011349-bykvn367.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-011349-bykvn367.txt' === file2bib.sh === id: cord-011297-4um9w2dx author: Brunker, Lucille title: New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report date: 2019-11-28 pages: extension: .txt txt: ./txt/cord-011297-4um9w2dx.txt cache: ./cache/cord-011297-4um9w2dx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-011297-4um9w2dx.txt' === file2bib.sh === id: cord-010921-yzv43e8l author: Kaye, Alan David title: Dexmedetomidine in Enhanced Recovery After Surgery (ERAS) Protocols for Postoperative Pain date: 2020-04-02 pages: extension: .txt txt: ./txt/cord-010921-yzv43e8l.txt cache: ./cache/cord-010921-yzv43e8l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010921-yzv43e8l.txt' === file2bib.sh === id: cord-010929-d598h08w author: Kashiwagi, Hirokazu title: Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision date: 2020-01-02 pages: extension: .txt txt: ./txt/cord-010929-d598h08w.txt cache: ./cache/cord-010929-d598h08w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010929-d598h08w.txt' === file2bib.sh === id: cord-011284-u4qmvz3c author: Livingston, Nicholas A. title: Addressing Diversity in PTSD Treatment: Clinical Considerations and Guidance for the Treatment of PTSD in LGBTQ Populations date: 2020-03-16 pages: extension: .txt txt: ./txt/cord-011284-u4qmvz3c.txt cache: ./cache/cord-011284-u4qmvz3c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011284-u4qmvz3c.txt' === file2bib.sh === id: cord-009417-458rrhcm author: Luce, Judith A. title: Use of Blood Components in the Intensive Care Unit date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-009417-458rrhcm.txt cache: ./cache/cord-009417-458rrhcm.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009417-458rrhcm.txt' === file2bib.sh === id: cord-011093-d9dbvbcy author: Orange, Jordan S. title: How I Manage Natural Killer Cell Deficiency date: 2019-11-22 pages: extension: .txt txt: ./txt/cord-011093-d9dbvbcy.txt cache: ./cache/cord-011093-d9dbvbcy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011093-d9dbvbcy.txt' === file2bib.sh === id: cord-011181-9nvwk04v author: Jakimovska, Vesna Miloshevska title: Epidemiological characteristics and early complications after spinal cord injury in Former Yugoslav Republic of Macedonia date: 2019-08-19 pages: extension: .txt txt: ./txt/cord-011181-9nvwk04v.txt cache: ./cache/cord-011181-9nvwk04v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011181-9nvwk04v.txt' === file2bib.sh === id: cord-011512-gw2sk90q author: Houlston, E. title: A simple pleasure date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-011512-gw2sk90q.txt cache: ./cache/cord-011512-gw2sk90q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011512-gw2sk90q.txt' === file2bib.sh === id: cord-011975-8vl45xb7 author: Keser, Tobias title: Risk Factors for Dysphagia and the Impact on Outcome After Spontaneous Subarachnoid Hemorrhage date: 2019-11-15 pages: extension: .txt txt: ./txt/cord-011975-8vl45xb7.txt cache: ./cache/cord-011975-8vl45xb7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-011975-8vl45xb7.txt' === file2bib.sh === id: cord-011712-fyrbe8tw author: Venkatesan, Sudhir title: Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection date: 2020-02-01 pages: extension: .txt txt: ./txt/cord-011712-fyrbe8tw.txt cache: ./cache/cord-011712-fyrbe8tw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011712-fyrbe8tw.txt' === file2bib.sh === id: cord-011725-t1jl4cy1 author: Varma, Niraj title: HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-011725-t1jl4cy1.txt cache: ./cache/cord-011725-t1jl4cy1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-011725-t1jl4cy1.txt' === file2bib.sh === id: cord-011649-3dlsy8fl author: Limoncelli, Janine title: General Anesthesia Recommendations for Electroconvulsive Therapy During the Coronavirus Disease 2019 Pandemic date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-011649-3dlsy8fl.txt cache: ./cache/cord-011649-3dlsy8fl.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-011649-3dlsy8fl.txt' === file2bib.sh === id: cord-011221-rhyxp4v5 author: Fu, Chih-Yuan title: Obesity is Associated with Worse Outcomes Among Abdominal Trauma Patients Undergoing Laparotomy: A Propensity-Matched Nationwide Cohort Study date: 2019-11-11 pages: extension: .txt txt: ./txt/cord-011221-rhyxp4v5.txt cache: ./cache/cord-011221-rhyxp4v5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011221-rhyxp4v5.txt' === file2bib.sh === id: cord-011413-yv4x8viu author: Shekar, Kiran title: Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-011413-yv4x8viu.txt cache: ./cache/cord-011413-yv4x8viu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011413-yv4x8viu.txt' === file2bib.sh === id: cord-011483-zc6ve6le author: Leclerc, Angela M. title: Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-011483-zc6ve6le.txt cache: ./cache/cord-011483-zc6ve6le.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-011483-zc6ve6le.txt' === file2bib.sh === id: cord-012117-c693oefo author: Diaz-Padilla, Ivan title: A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors date: 2013-10-01 pages: extension: .txt txt: ./txt/cord-012117-c693oefo.txt cache: ./cache/cord-012117-c693oefo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-012117-c693oefo.txt' === file2bib.sh === id: cord-012665-fflye8a3 author: Marques-Vidal, Pedro title: Statistical issues regarding the article by Liu et al. date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-012665-fflye8a3.txt cache: ./cache/cord-012665-fflye8a3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-012665-fflye8a3.txt' === file2bib.sh === id: cord-012459-tge08va0 author: Matthews, Laura J. title: Airway Alert Bracelets: Enhancing Safety in the Coronavirus Disease 2019 Era date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-012459-tge08va0.txt cache: ./cache/cord-012459-tge08va0.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-012459-tge08va0.txt' === file2bib.sh === id: cord-010398-5wot7tix author: Clauw, Daniel J. title: Perspectives on Fatigue from the Study of Chronic Fatigue Syndrome and Related Conditions date: 2010-05-31 pages: extension: .txt txt: ./txt/cord-010398-5wot7tix.txt cache: ./cache/cord-010398-5wot7tix.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-010398-5wot7tix.txt' === file2bib.sh === id: cord-011103-sstpidvk author: Younan, Duraid title: Factors Predictive of Ventilator-associated Pneumonia in Critically Ill Trauma Patients date: 2019-11-26 pages: extension: .txt txt: ./txt/cord-011103-sstpidvk.txt cache: ./cache/cord-011103-sstpidvk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-011103-sstpidvk.txt' === file2bib.sh === id: cord-011793-hlktpla4 author: Rice, Todd W. title: In Defense of Evidence-based Medicine for the Treatment of COVID-19 Acute Respiratory Distress Syndrome date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-011793-hlktpla4.txt cache: ./cache/cord-011793-hlktpla4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-011793-hlktpla4.txt' === file2bib.sh === id: cord-013035-7sfj0czv author: Savinelli, Stefano title: Reply date: 2020-09-20 pages: extension: .txt txt: ./txt/cord-013035-7sfj0czv.txt cache: ./cache/cord-013035-7sfj0czv.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-013035-7sfj0czv.txt' === file2bib.sh === id: cord-011327-zsoc4wec author: Martin-Loeches, Ignacio title: Antibiotic prophylaxis in the ICU: to be or not to be administered for patients undergoing procedures? date: 2019-11-28 pages: extension: .txt txt: ./txt/cord-011327-zsoc4wec.txt cache: ./cache/cord-011327-zsoc4wec.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011327-zsoc4wec.txt' === file2bib.sh === id: cord-011875-ga0dzj3v author: Tsolaki, Vasiliki title: Are Patients with COVID-19 Dying of or with Cardiac Injury? date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-011875-ga0dzj3v.txt cache: ./cache/cord-011875-ga0dzj3v.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011875-ga0dzj3v.txt' === file2bib.sh === id: cord-009512-o4y9s8zf author: Huang, Jiajia title: Primary pulmonary non‐Hodgkin's lymphoma: A retrospective analysis of 29 cases in a Chinese population date: 2010-03-24 pages: extension: .txt txt: ./txt/cord-009512-o4y9s8zf.txt cache: ./cache/cord-009512-o4y9s8zf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-009512-o4y9s8zf.txt' === file2bib.sh === id: cord-006226-fn7zlutj author: nan title: Abstracts of the 4th annual meeting of the German Society of Clinical Pharmacology and Therapy: Hannover, 14–17 September 1994 date: 1994 pages: extension: .txt txt: ./txt/cord-006226-fn7zlutj.txt cache: ./cache/cord-006226-fn7zlutj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006226-fn7zlutj.txt' === file2bib.sh === id: cord-012037-9kmul7he author: Veenis, J. F. title: Remote monitoring of chronic heart failure patients: invasive versus non-invasive tools for optimising patient management date: 2019-11-19 pages: extension: .txt txt: ./txt/cord-012037-9kmul7he.txt cache: ./cache/cord-012037-9kmul7he.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-012037-9kmul7he.txt' === file2bib.sh === id: cord-013149-y0dbhtef author: Wohlfarth, P. title: Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-013149-y0dbhtef.txt cache: ./cache/cord-013149-y0dbhtef.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-013149-y0dbhtef.txt' === file2bib.sh === id: cord-011302-pfepyvaw author: Edlmann, Ellie title: The changing face of neurosurgery for the older person date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-011302-pfepyvaw.txt cache: ./cache/cord-011302-pfepyvaw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011302-pfepyvaw.txt' === file2bib.sh === id: cord-013003-gxd29jxf author: Vora, Darshan title: Surgical management of a complex case of Charcot arthropathy of the spine: a case report date: 2019-08-22 pages: extension: .txt txt: ./txt/cord-013003-gxd29jxf.txt cache: ./cache/cord-013003-gxd29jxf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-013003-gxd29jxf.txt' === file2bib.sh === id: cord-013116-n7auvqh3 author: Srinivas, A. title: Testing the limits of UDCs date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-013116-n7auvqh3.txt cache: ./cache/cord-013116-n7auvqh3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-013116-n7auvqh3.txt' === file2bib.sh === id: cord-013139-b32xg7y7 author: Colak, Fatma Kurt title: An intronic variant in BRAT1 creates a cryptic splice site, causing epileptic encephalopathy without prominent rigidity date: 2020-10-10 pages: extension: .txt txt: ./txt/cord-013139-b32xg7y7.txt cache: ./cache/cord-013139-b32xg7y7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-013139-b32xg7y7.txt' === file2bib.sh === id: cord-012778-yr8zuvw9 author: Zhang, Lei title: Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China date: 2019-08-06 pages: extension: .txt txt: ./txt/cord-012778-yr8zuvw9.txt cache: ./cache/cord-012778-yr8zuvw9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-012778-yr8zuvw9.txt' === file2bib.sh === id: cord-010078-8lkkez3n author: nan title: Invited Speakers date: 2010-11-24 pages: extension: .txt txt: ./txt/cord-010078-8lkkez3n.txt cache: ./cache/cord-010078-8lkkez3n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010078-8lkkez3n.txt' === file2bib.sh === id: cord-006924-1i3kf01j author: nan title: Abstracts from USCAP 2020: Pulmonary, Mediastinum, Pleura, and Peritoneum Pathology (1869-1980) date: 2020-03-05 pages: extension: .txt txt: ./txt/cord-006924-1i3kf01j.txt cache: ./cache/cord-006924-1i3kf01j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006924-1i3kf01j.txt' === file2bib.sh === id: cord-012115-hpsxi9ay author: Archie, Patrick title: Music-based interventions in palliative cancer care: a review of quantitative studies and neurobiological literature date: 2013-05-30 pages: extension: .txt txt: ./txt/cord-012115-hpsxi9ay.txt cache: ./cache/cord-012115-hpsxi9ay.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-012115-hpsxi9ay.txt' === file2bib.sh === id: cord-013105-tmhce7p5 author: Kalil, Andre C. title: Less is more: critically ill status is not a carte blanche for unlimited antibiotic use date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-013105-tmhce7p5.txt cache: ./cache/cord-013105-tmhce7p5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-013105-tmhce7p5.txt' === file2bib.sh === id: cord-010933-xuztu95a author: Davis, Samuel title: Theoretical bounds and approximation of the probability mass function of future hospital bed demand date: 2018-11-06 pages: extension: .txt txt: ./txt/cord-010933-xuztu95a.txt cache: ./cache/cord-010933-xuztu95a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-010933-xuztu95a.txt' === file2bib.sh === id: cord-013370-gktnz644 author: Abreu, Maria T title: Providing Guidance During a Global Viral Pandemic for the Care of Patients With Inflammatory Bowel Disease date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-013370-gktnz644.txt cache: ./cache/cord-013370-gktnz644.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-013370-gktnz644.txt' === file2bib.sh === id: cord-006702-ekf6mja9 author: nan title: Abstracts for the 17th IPNA Congress, Iguaçu, Brazil, September 2016: Oral Presentations date: 2016-08-17 pages: extension: .txt txt: ./txt/cord-006702-ekf6mja9.txt cache: ./cache/cord-006702-ekf6mja9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006702-ekf6mja9.txt' === file2bib.sh === id: cord-007798-9ht7cqhu author: Smith, Silas W. title: Drugs and pharmaceuticals: management of intoxication and antidotes date: 2010-02-25 pages: extension: .txt txt: ./txt/cord-007798-9ht7cqhu.txt cache: ./cache/cord-007798-9ht7cqhu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-007798-9ht7cqhu.txt' === file2bib.sh === id: cord-011188-59hn9wsv author: Bruce, Lori title: A Pot Ignored Boils On: Sustained Calls for Explicit Consent of Intimate Medical Exams date: 2020-03-09 pages: extension: .txt txt: ./txt/cord-011188-59hn9wsv.txt cache: ./cache/cord-011188-59hn9wsv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011188-59hn9wsv.txt' === file2bib.sh === id: cord-013558-0sa63lp3 author: Farwana, Reem title: Watch this space: a systematic review of the use of video-based media as a patient education tool in ophthalmology date: 2020-03-09 pages: extension: .txt txt: ./txt/cord-013558-0sa63lp3.txt cache: ./cache/cord-013558-0sa63lp3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-013558-0sa63lp3.txt' === file2bib.sh === id: cord-008695-y7il3hyb author: nan title: Pandemic Flu: Clinical management of patients with an influenza-like illness during an influenza pandemic date: 2007-01-25 pages: extension: .txt txt: ./txt/cord-008695-y7il3hyb.txt cache: ./cache/cord-008695-y7il3hyb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-008695-y7il3hyb.txt' === file2bib.sh === id: cord-014933-3jezc081 author: Özdemir, Seray Karagöz title: Investigation of seasonal frequency and pathogens in febrile neutropenia date: 2019-01-15 pages: extension: .txt txt: ./txt/cord-014933-3jezc081.txt cache: ./cache/cord-014933-3jezc081.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-014933-3jezc081.txt' === file2bib.sh === id: cord-006856-b1w25ob5 author: nan title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date: 2005 pages: extension: .txt txt: ./txt/cord-006856-b1w25ob5.txt cache: ./cache/cord-006856-b1w25ob5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006856-b1w25ob5.txt' === file2bib.sh === id: cord-012934-c6pbr64i author: Hao, Weiming title: Vestibular prognosis in idiopathic sudden sensorineural hearing loss with vestibular dysfunction treated with oral or intratympanic glucocorticoids: a protocol for randomized controlled trial date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-012934-c6pbr64i.txt cache: ./cache/cord-012934-c6pbr64i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-012934-c6pbr64i.txt' === file2bib.sh === id: cord-013148-qbxbndsl author: Manzano-Nunez, Ramiro title: Outcomes and management approaches of resuscitative endovascular balloon occlusion of the aorta based on the income of countries date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-013148-qbxbndsl.txt cache: ./cache/cord-013148-qbxbndsl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-013148-qbxbndsl.txt' === file2bib.sh === id: cord-013589-3l8kar3k author: Doummar, Diane title: Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-013589-3l8kar3k.txt cache: ./cache/cord-013589-3l8kar3k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-013589-3l8kar3k.txt' === file2bib.sh === id: cord-012560-p5s0p7fd author: Decavèle, Maxens title: One-year survival of patients with high-grade glioma discharged alive from the intensive care unit date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-012560-p5s0p7fd.txt cache: ./cache/cord-012560-p5s0p7fd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-012560-p5s0p7fd.txt' === file2bib.sh === id: cord-013380-1jwzbgwb author: Parrilla, Claudio title: A one-year time frame for voice prosthesis management. What should the physician expect? Is it an overrated job? date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-013380-1jwzbgwb.txt cache: ./cache/cord-013380-1jwzbgwb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-013380-1jwzbgwb.txt' === file2bib.sh === id: cord-014833-ax09x6gk author: Wu, Jia title: Data Decision and Transmission Based on Mobile Data Health Records on Sensor Devices in Wireless Networks date: 2016-06-20 pages: extension: .txt txt: ./txt/cord-014833-ax09x6gk.txt cache: ./cache/cord-014833-ax09x6gk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-014833-ax09x6gk.txt' === file2bib.sh === id: cord-012469-6cvu5umd author: Lewis, Jayne title: Speaking with Frankenstein date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-012469-6cvu5umd.txt cache: ./cache/cord-012469-6cvu5umd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-012469-6cvu5umd.txt' === file2bib.sh === id: cord-006862-5va1yyit author: nan title: ITS ASM 2012 date: 2012-11-04 pages: extension: .txt txt: ./txt/cord-006862-5va1yyit.txt cache: ./cache/cord-006862-5va1yyit.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006862-5va1yyit.txt' === file2bib.sh === id: cord-016237-sk1wzghx author: Zhang, Chen title: Infectious Diseases date: 2018-09-07 pages: extension: .txt txt: ./txt/cord-016237-sk1wzghx.txt cache: ./cache/cord-016237-sk1wzghx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-016237-sk1wzghx.txt' === file2bib.sh === id: cord-013457-rqon1adg author: De Cannière, Hélène title: Short-Term Exercise Progression of Cardiovascular Patients throughout Cardiac Rehabilitation: An Observational Study date: 2020-09-29 pages: extension: .txt txt: ./txt/cord-013457-rqon1adg.txt cache: ./cache/cord-013457-rqon1adg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-013457-rqon1adg.txt' === file2bib.sh === id: cord-012902-efprpk72 author: nan title: Abstracts from the 2020 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS) date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-012902-efprpk72.txt cache: ./cache/cord-012902-efprpk72.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-012902-efprpk72.txt' === file2bib.sh === id: cord-015930-18qznqp0 author: Denstaedt, Scott J. title: Hemophagocytic Lymphohistiocytosis and Other Culture Negative Sepsis-Like Syndromes in the ICU date: 2019-07-24 pages: extension: .txt txt: ./txt/cord-015930-18qznqp0.txt cache: ./cache/cord-015930-18qznqp0.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015930-18qznqp0.txt' === file2bib.sh === id: cord-015162-6be21d59 author: nan title: Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin date: 2016-05-04 pages: extension: .txt txt: ./txt/cord-015162-6be21d59.txt cache: ./cache/cord-015162-6be21d59.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-015162-6be21d59.txt' === file2bib.sh === id: cord-014980-cz1gx9oj author: Cheng, Qinglin title: Nomogram for the Individualized Prediction of Survival Among Patients with H7N9 Infection date: 2020-03-20 pages: extension: .txt txt: ./txt/cord-014980-cz1gx9oj.txt cache: ./cache/cord-014980-cz1gx9oj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-014980-cz1gx9oj.txt' === file2bib.sh === id: cord-006888-qfnukav4 author: nan title: Irish Thoracic Society Annual Scientific Meeting, Ramada Hotel, Belfast: 7th–8th November 2008 date: 2008-10-21 pages: extension: .txt txt: ./txt/cord-006888-qfnukav4.txt cache: ./cache/cord-006888-qfnukav4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006888-qfnukav4.txt' === file2bib.sh === id: cord-006828-i88on326 author: nan title: Abstracts DGRh-Kongress 2013 date: 2013-09-15 pages: extension: .txt txt: ./txt/cord-006828-i88on326.txt cache: ./cache/cord-006828-i88on326.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-006828-i88on326.txt' === file2bib.sh === id: cord-016135-44pgjah8 author: Sen, Ayan title: Postoperative Management of Composite Tissue Graft Transplantation date: 2016-06-03 pages: extension: .txt txt: ./txt/cord-016135-44pgjah8.txt cache: ./cache/cord-016135-44pgjah8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016135-44pgjah8.txt' === file2bib.sh === id: cord-015884-mtpbzgr9 author: Haynes, Alice title: Current Practices for Infection Prevention in the Hospital Settings date: 2013-08-06 pages: extension: .txt txt: ./txt/cord-015884-mtpbzgr9.txt cache: ./cache/cord-015884-mtpbzgr9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-015884-mtpbzgr9.txt' === file2bib.sh === id: cord-011836-zib8wkm2 author: Urman, Jesús M. title: Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach date: 2020-06-21 pages: extension: .txt txt: ./txt/cord-011836-zib8wkm2.txt cache: ./cache/cord-011836-zib8wkm2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011836-zib8wkm2.txt' === file2bib.sh === id: cord-015946-biu5zxd1 author: Peng, Daizhi title: Research Advances in Biomarker for Sepsis date: 2016-11-16 pages: extension: .txt txt: ./txt/cord-015946-biu5zxd1.txt cache: ./cache/cord-015946-biu5zxd1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-015946-biu5zxd1.txt' === file2bib.sh === id: cord-014965-efmozngq author: nan title: Infectious diseases other than CMV (1st Section) date: 2001-06-11 pages: extension: .txt txt: ./txt/cord-014965-efmozngq.txt cache: ./cache/cord-014965-efmozngq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-014965-efmozngq.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 93. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-016248-dxk0i6t7 author: Papa, Joey C. title: Extracorporeal Membrane Oxygenation date: 2009 pages: extension: .txt txt: ./txt/cord-016248-dxk0i6t7.txt cache: ./cache/cord-016248-dxk0i6t7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016248-dxk0i6t7.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-015335-l0kjxhd1 author: nan title: Irish Society of Gastroenterology: Proceedings for summer meeting – 26th/27th May 1995 in Galway date: 1995 pages: extension: .txt txt: ./txt/cord-015335-l0kjxhd1.txt cache: ./cache/cord-015335-l0kjxhd1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-015335-l0kjxhd1.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 93. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-016208-u12ngkpc author: Andersen, Bjørg Marit title: Intensive Patient Treatment date: 2018-09-25 pages: extension: .txt txt: ./txt/cord-016208-u12ngkpc.txt cache: ./cache/cord-016208-u12ngkpc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016208-u12ngkpc.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 93. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 74742 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 92. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 93. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 93. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 91. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 92. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 87839 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 91. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 92. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 87780 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 88412 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-014987-nycbjqn6 author: nan title: OP 0364-0412 date: 2006-08-24 pages: extension: .txt txt: ./txt/cord-014987-nycbjqn6.txt cache: ./cache/cord-014987-nycbjqn6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-014987-nycbjqn6.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 89216 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-016127-tbot0fc9 author: Hurtado, F. J. title: Sepsis: Clinical Approach, Evidence-Based at the Bedside date: 2009-11-19 pages: extension: .txt txt: ./txt/cord-016127-tbot0fc9.txt cache: ./cache/cord-016127-tbot0fc9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-016127-tbot0fc9.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-016110-mlwe7fzz author: Specks, Ulrich title: Pulmonary Manifestations of Vasculitis date: 2014-05-05 pages: extension: .txt txt: ./txt/cord-016110-mlwe7fzz.txt cache: ./cache/cord-016110-mlwe7fzz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-016110-mlwe7fzz.txt' === file2bib.sh === id: cord-016601-gp259urb author: Bonadonna, Lucia title: Analysis of Microorganisms in Hospital Environments and Potential Risks date: 2017-03-24 pages: extension: .txt txt: ./txt/cord-016601-gp259urb.txt cache: ./cache/cord-016601-gp259urb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016601-gp259urb.txt' /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-015640-zdwmxaz3 author: Tong, C. Y. W. title: Clinical Virology in NICU, PICU and AICU date: 2011-08-10 pages: extension: .txt txt: ./txt/cord-015640-zdwmxaz3.txt cache: ./cache/cord-015640-zdwmxaz3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015640-zdwmxaz3.txt' === file2bib.sh === id: cord-016280-d47e3art author: Friedberg, Joseph S. title: Pleura: Anatomy, Physiology, and Disorders date: 2008 pages: extension: .txt txt: ./txt/cord-016280-d47e3art.txt cache: ./cache/cord-016280-d47e3art.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016280-d47e3art.txt' === file2bib.sh === id: cord-016211-8j8n9enn author: Lu, Puxuan title: Highly Pathogenic Avian Influenza date: 2015-04-30 pages: extension: .txt txt: ./txt/cord-016211-8j8n9enn.txt cache: ./cache/cord-016211-8j8n9enn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016211-8j8n9enn.txt' === file2bib.sh === id: cord-016105-jkaxemmb author: Nakao, Mutsuhiro title: Prevention and Psychological Intervention in Depression and Stress-Related Conditions date: 2011 pages: extension: .txt txt: ./txt/cord-016105-jkaxemmb.txt cache: ./cache/cord-016105-jkaxemmb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016105-jkaxemmb.txt' /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 90. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-016308-qzkcwrit author: Cochran, Christina L. title: Neonatal Emergencies date: 2015-11-06 pages: extension: .txt txt: ./txt/cord-016308-qzkcwrit.txt cache: ./cache/cord-016308-qzkcwrit.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016308-qzkcwrit.txt' === file2bib.sh === id: cord-016177-fz48wydz author: Bezek, Sarah title: Emergency Triage of Highly Infectious Diseases and Bioterrorism date: 2020-01-03 pages: extension: .txt txt: ./txt/cord-016177-fz48wydz.txt cache: ./cache/cord-016177-fz48wydz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-016177-fz48wydz.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 90088 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 93360 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 71728 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-016498-j72vrvqf author: Fong, I. W. title: Issues in Community-Acquired Pneumonia date: 2020-03-07 pages: extension: .txt txt: ./txt/cord-016498-j72vrvqf.txt cache: ./cache/cord-016498-j72vrvqf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016498-j72vrvqf.txt' /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-015922-5wwy0m2k author: Marty, Francisco M. title: Infection in the Hematopoietic Stem Cell Transplant Recipient date: 2008 pages: extension: .txt txt: ./txt/cord-015922-5wwy0m2k.txt cache: ./cache/cord-015922-5wwy0m2k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-015922-5wwy0m2k.txt' === file2bib.sh === id: cord-016413-lvb79oxo author: Efthimiou, Petros title: Adult-Onset Still’s Disease date: 2018-07-14 pages: extension: .txt txt: ./txt/cord-016413-lvb79oxo.txt cache: ./cache/cord-016413-lvb79oxo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016413-lvb79oxo.txt' === file2bib.sh === id: cord-006391-esnsa4u5 author: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 pages: extension: .txt txt: ./txt/cord-006391-esnsa4u5.txt cache: ./cache/cord-006391-esnsa4u5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006391-esnsa4u5.txt' === file2bib.sh === id: cord-016300-vw11c2wt author: Jain, Kewal K. title: Biomarkers of Pulmonary Diseases date: 2017-09-18 pages: extension: .txt txt: ./txt/cord-016300-vw11c2wt.txt cache: ./cache/cord-016300-vw11c2wt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016300-vw11c2wt.txt' === file2bib.sh === id: cord-016301-vqmqnipq author: Winnick, Aaron M. title: Elderly Transplant Recipients date: 2011-01-25 pages: extension: .txt txt: ./txt/cord-016301-vqmqnipq.txt cache: ./cache/cord-016301-vqmqnipq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016301-vqmqnipq.txt' === file2bib.sh === id: cord-006864-t5qsjyfi author: Norris, S. title: National scientific medical meeting 1995 abstracts: Oral presentations date: 1995 pages: extension: .txt txt: ./txt/cord-006864-t5qsjyfi.txt cache: ./cache/cord-006864-t5qsjyfi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006864-t5qsjyfi.txt' === file2bib.sh === id: cord-016871-1mlamf20 author: Streiff, Agathe title: Hemorrhage and Transfusions in the Surgical Patient date: 2012-10-30 pages: extension: .txt txt: ./txt/cord-016871-1mlamf20.txt cache: ./cache/cord-016871-1mlamf20.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016871-1mlamf20.txt' === file2bib.sh === id: cord-016572-6fu5s89c author: Hage, Chadi A. title: Endemic mycosis date: 2005 pages: extension: .txt txt: ./txt/cord-016572-6fu5s89c.txt cache: ./cache/cord-016572-6fu5s89c.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016572-6fu5s89c.txt' === file2bib.sh === id: cord-016460-39yniw0t author: Ben-Chetrit, Eldad title: Colchicine date: 2018-07-31 pages: extension: .txt txt: ./txt/cord-016460-39yniw0t.txt cache: ./cache/cord-016460-39yniw0t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016460-39yniw0t.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 91. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 92. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 80663 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 90. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 38460 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 4358 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-016235-2lhrkmrv author: Roden, Anja C. title: Lung date: 2010-05-17 pages: extension: .txt txt: ./txt/cord-016235-2lhrkmrv.txt cache: ./cache/cord-016235-2lhrkmrv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016235-2lhrkmrv.txt' === file2bib.sh === id: cord-010075-72jodunj author: nan title: Paediatric SIG: Poster Session date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-010075-72jodunj.txt cache: ./cache/cord-010075-72jodunj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-010075-72jodunj.txt' === file2bib.sh === id: cord-006444-eq56zhtd author: nan title: Abstracts of oral presentations and posters date: 1993 pages: extension: .txt txt: ./txt/cord-006444-eq56zhtd.txt cache: ./cache/cord-006444-eq56zhtd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006444-eq56zhtd.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-015569-vy49r1zd author: nan title: Abstracts from the 45(th) Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7(th), 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University) date: 2012-05-17 pages: extension: .txt txt: ./txt/cord-015569-vy49r1zd.txt cache: ./cache/cord-015569-vy49r1zd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015569-vy49r1zd.txt' === file2bib.sh === id: cord-016478-gpl0zbvd author: Barry, Maura title: Cytopenias in Transplant Patients date: 2018-12-08 pages: extension: .txt txt: ./txt/cord-016478-gpl0zbvd.txt cache: ./cache/cord-016478-gpl0zbvd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016478-gpl0zbvd.txt' === file2bib.sh === id: cord-017040-4zajnrsf author: Rihana, Nancy title: Skin Infections date: 2019-08-11 pages: extension: .txt txt: ./txt/cord-017040-4zajnrsf.txt cache: ./cache/cord-017040-4zajnrsf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-017040-4zajnrsf.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 92. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 91. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 89. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-017350-rwqaw5ii author: Venet, F. title: Monitoring Immune Dysfunction in Septic Patients: Toward Tailored Immunotherapy date: 2010-03-10 pages: extension: .txt txt: ./txt/cord-017350-rwqaw5ii.txt cache: ./cache/cord-017350-rwqaw5ii.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017350-rwqaw5ii.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-016814-tf17dpo5 author: Enes, Sara Rolandsson title: Clinical Application of Stem/Stromal Cells in COPD date: 2019-08-07 pages: extension: .txt txt: ./txt/cord-016814-tf17dpo5.txt cache: ./cache/cord-016814-tf17dpo5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016814-tf17dpo5.txt' === file2bib.sh === id: cord-017374-clctlm5l author: Diamantaki, Eleni title: Acute Respiratory Failure Before ICU Admission: A Practical Approach date: 2017-06-28 pages: extension: .txt txt: ./txt/cord-017374-clctlm5l.txt cache: ./cache/cord-017374-clctlm5l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017374-clctlm5l.txt' === file2bib.sh === id: cord-017337-vq3edhxn author: Vincent, Jean-Louis title: PIRO: The Key to Success? date: 2009 pages: extension: .txt txt: ./txt/cord-017337-vq3edhxn.txt cache: ./cache/cord-017337-vq3edhxn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017337-vq3edhxn.txt' === file2bib.sh === id: cord-017531-fm8gl5b3 author: Andersen, Bjørg Marit title: Scenarios: Serious, Infectious Diseases date: 2018-09-25 pages: extension: .txt txt: ./txt/cord-017531-fm8gl5b3.txt cache: ./cache/cord-017531-fm8gl5b3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017531-fm8gl5b3.txt' === file2bib.sh === id: cord-017302-xez0zso3 author: Stephens, R. Scott title: ICU Complications of Hematopoietic Stem Cell Transplant, Including Graft vs Host Disease date: 2019-07-24 pages: extension: .txt txt: ./txt/cord-017302-xez0zso3.txt cache: ./cache/cord-017302-xez0zso3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017302-xez0zso3.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 11624 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 91. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 89. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 90. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 12899 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 11813 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 10657 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 13440 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-016982-qt25tp6t author: Fong, I. W. title: Litigations for Unexpected Adverse Events date: 2010-11-30 pages: extension: .txt txt: ./txt/cord-016982-qt25tp6t.txt cache: ./cache/cord-016982-qt25tp6t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016982-qt25tp6t.txt' === file2bib.sh === id: cord-017392-ja9b5vy9 author: Waterer, G. W. title: Adjunctive and Supportive Measures for Community-Acquired Pneumonia date: 2010-05-20 pages: extension: .txt txt: ./txt/cord-017392-ja9b5vy9.txt cache: ./cache/cord-017392-ja9b5vy9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017392-ja9b5vy9.txt' /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-014540-27hnlu5v author: Sutthiruk, Nantanit title: Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC): Bangkok, Thailand. 12-15 February 2017 date: 2017-02-22 pages: extension: .txt txt: ./txt/cord-014540-27hnlu5v.txt cache: ./cache/cord-014540-27hnlu5v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-014540-27hnlu5v.txt' /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-017324-l3d3t4wh author: DjukanoviĆ, Ljubica title: Balkan nephropathy date: 2008 pages: extension: .txt txt: ./txt/cord-017324-l3d3t4wh.txt cache: ./cache/cord-017324-l3d3t4wh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017324-l3d3t4wh.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes cp: cannot stat ‘/data-disk/reader-compute/reader-cord/cord/pos/cord-266105-8avkjc84.pos’: No such file or directory parallel: Warning: No more processes: Decreasing number of running jobs to 90. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. cp: cannot stat ‘/data-disk/reader-compute/reader-cord/cord/wrd/cord-266105-8avkjc84.wrd’: No such file or directory parallel: Warning: No more processes: Decreasing number of running jobs to 89. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-017420-tjwxec77 author: Stephens, R. Scott title: Neutropenic Fever in the Intensive Care Unit date: 2019-07-09 pages: extension: .txt txt: ./txt/cord-017420-tjwxec77.txt cache: ./cache/cord-017420-tjwxec77.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017420-tjwxec77.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-017217-zjab7o2o author: Ali, Yousaf title: Self Assessment Questions date: 2008-01-08 pages: extension: .txt txt: ./txt/cord-017217-zjab7o2o.txt cache: ./cache/cord-017217-zjab7o2o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017217-zjab7o2o.txt' === file2bib.sh === id: cord-015082-l629n8is author: nan title: Poster Sessions 323-461 date: 2002-08-29 pages: extension: .txt txt: ./txt/cord-015082-l629n8is.txt cache: ./cache/cord-015082-l629n8is.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015082-l629n8is.txt' === file2bib.sh === id: cord-017489-ftz9190a author: Richards, Guy A. title: Viruses in the Intensive Care Unit (ICU) date: 2005 pages: extension: .txt txt: ./txt/cord-017489-ftz9190a.txt cache: ./cache/cord-017489-ftz9190a.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017489-ftz9190a.txt' === file2bib.sh === id: cord-017142-vx3rgs4r author: Nair, Ranjit title: What the Intensivists Need to Know About Critically Ill Myeloma Patients date: 2019-07-09 pages: extension: .txt txt: ./txt/cord-017142-vx3rgs4r.txt cache: ./cache/cord-017142-vx3rgs4r.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017142-vx3rgs4r.txt' === file2bib.sh === id: cord-017516-qbksb83c author: Si, Yain-Whar title: Hidden Cluster Detection for Infectious Disease Control and Quarantine Management date: 2009-09-30 pages: extension: .txt txt: ./txt/cord-017516-qbksb83c.txt cache: ./cache/cord-017516-qbksb83c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017516-qbksb83c.txt' === file2bib.sh === id: cord-015090-n6f4xupw author: nan title: PS 339-563 date: 2005-09-10 pages: extension: .txt txt: ./txt/cord-015090-n6f4xupw.txt cache: ./cache/cord-015090-n6f4xupw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-015090-n6f4xupw.txt' /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes cp: cannot stat ‘/data-disk/reader-compute/reader-cord/cord/ent/cord-266105-8avkjc84.ent’: No such file or directory parallel: Warning: No more processes: Decreasing number of running jobs to 88. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18060 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18381 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 88. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 89. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-017581-6lubp7io author: Glass, Daniel M. title: Respiratory Diseases of Pregnancy date: 2019-07-24 pages: extension: .txt txt: ./txt/cord-017581-6lubp7io.txt cache: ./cache/cord-017581-6lubp7io.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017581-6lubp7io.txt' === file2bib.sh === id: cord-017461-xw02c7u5 author: Kauffman, Carol A. title: Fungal Infections date: 2009-02-02 pages: extension: .txt txt: ./txt/cord-017461-xw02c7u5.txt cache: ./cache/cord-017461-xw02c7u5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017461-xw02c7u5.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-010027-r0tl01kq author: nan title: Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland date: 2015-09-15 pages: extension: .txt txt: ./txt/cord-010027-r0tl01kq.txt cache: ./cache/cord-010027-r0tl01kq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-010027-r0tl01kq.txt' /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes === file2bib.sh === id: cord-017534-0ai8chbu author: Andersen, Bjørg Marit title: Background Information: Isolation Routines date: 2018-09-25 pages: extension: .txt txt: ./txt/cord-017534-0ai8chbu.txt cache: ./cache/cord-017534-0ai8chbu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017534-0ai8chbu.txt' === file2bib.sh === id: cord-015389-vwgai4k9 author: nan title: Publication only date: 2009-03-25 pages: extension: .txt txt: ./txt/cord-015389-vwgai4k9.txt cache: ./cache/cord-015389-vwgai4k9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015389-vwgai4k9.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 90. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 89. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18573 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 20483 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 88. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18956 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 87. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 88. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 88. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18836 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 87. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 86. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 87. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 86. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 85. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 87. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 87. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53577 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes id: cord-017772-zpf1xjqi author: Walter, James M. title: Thrombocytopenia in the Intensive Care Unit date: 2019-07-24 pages: extension: .txt txt: ./txt/cord-017772-zpf1xjqi.txt cache: ./cache/cord-017772-zpf1xjqi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017772-zpf1xjqi.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-017784-4r3fpmlb author: Foccillo, Giampiero title: The Infections Causing Acute Respiratory Failure in Elderly Patients date: 2019-08-06 pages: extension: .txt txt: ./txt/cord-017784-4r3fpmlb.txt cache: ./cache/cord-017784-4r3fpmlb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017784-4r3fpmlb.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-009571-mygj2nd4 author: nan title: Proceedings of the 42nd annual meeting of the american rheumatism association a section of the arthritis foundation june 1 & 2, 1978 new york city abstracts of papers presented date: 2005-11-23 pages: extension: .txt txt: ./txt/cord-009571-mygj2nd4.txt cache: ./cache/cord-009571-mygj2nd4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-009571-mygj2nd4.txt' === file2bib.sh === id: cord-016476-78r0rsio author: Jani, Meghna title: Management of the Rheumatoid Arthritis Patient with Interstitial Lung Disease date: 2017-11-29 pages: extension: .txt txt: ./txt/cord-016476-78r0rsio.txt cache: ./cache/cord-016476-78r0rsio.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016476-78r0rsio.txt' === file2bib.sh === id: cord-009713-sxd4t2tz author: nan title: Poster Presentations date: 2020-01-10 pages: extension: .txt txt: ./txt/cord-009713-sxd4t2tz.txt cache: ./cache/cord-009713-sxd4t2tz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-009713-sxd4t2tz.txt' === file2bib.sh === id: cord-012518-ncrdwtdg author: nan title: Abstractband DOG 2020 date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-012518-ncrdwtdg.txt cache: ./cache/cord-012518-ncrdwtdg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-012518-ncrdwtdg.txt' === file2bib.sh === id: cord-017862-9fkjjmvf author: Smith, Roger P. title: Respiratory Disorders date: 2007 pages: extension: .txt txt: ./txt/cord-017862-9fkjjmvf.txt cache: ./cache/cord-017862-9fkjjmvf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017862-9fkjjmvf.txt' === file2bib.sh === id: cord-017569-fv88n70v author: Hewlett, Angela title: Viral Hemorrhagic Fever Preparedness date: 2017-09-10 pages: extension: .txt txt: ./txt/cord-017569-fv88n70v.txt cache: ./cache/cord-017569-fv88n70v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017569-fv88n70v.txt' === file2bib.sh === id: cord-016559-tqd7m2i1 author: Zheng, Yi title: Application in Medicine Systems date: 2014-10-28 pages: extension: .txt txt: ./txt/cord-016559-tqd7m2i1.txt cache: ./cache/cord-016559-tqd7m2i1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-016559-tqd7m2i1.txt' === file2bib.sh === id: cord-018182-lleti89n author: Kassutto, Stacey M. title: Care of the Surgical ICU Patient with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension date: 2016-10-09 pages: extension: .txt txt: ./txt/cord-018182-lleti89n.txt cache: ./cache/cord-018182-lleti89n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018182-lleti89n.txt' === file2bib.sh === id: cord-018209-v2crgj5w author: Pastores, Stephen M. title: What Has Been Learned from Postmortem Studies? date: 2010-08-19 pages: extension: .txt txt: ./txt/cord-018209-v2crgj5w.txt cache: ./cache/cord-018209-v2crgj5w.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018209-v2crgj5w.txt' === file2bib.sh === id: cord-017799-2nvrakbs author: Patel, Zara M. title: Acute Bacterial Rhinosinusitis date: 2018-05-04 pages: extension: .txt txt: ./txt/cord-017799-2nvrakbs.txt cache: ./cache/cord-017799-2nvrakbs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017799-2nvrakbs.txt' === file2bib.sh === id: cord-014670-e31g8lns author: nan title: Poster Sessions 313-503 date: 2004-10-05 pages: extension: .txt txt: ./txt/cord-014670-e31g8lns.txt cache: ./cache/cord-014670-e31g8lns.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-014670-e31g8lns.txt' === file2bib.sh === id: cord-017883-6a4fkd5v author: Dutta, Ankhi title: Infection Prevention in Pediatric Oncology and Hematopoietic Stem Cell Transplant Recipients date: 2018-07-16 pages: extension: .txt txt: ./txt/cord-017883-6a4fkd5v.txt cache: ./cache/cord-017883-6a4fkd5v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017883-6a4fkd5v.txt' === file2bib.sh === id: cord-017393-kx8kmdej author: Herbers, Alexandra title: Acute Myelogenous Leukemia and Febrile Neutropenia date: 2009-08-31 pages: extension: .txt txt: ./txt/cord-017393-kx8kmdej.txt cache: ./cache/cord-017393-kx8kmdej.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017393-kx8kmdej.txt' === file2bib.sh === id: cord-017946-fa4ehlb0 author: Lawless, Ryan A. title: Adjuncts to Resuscitation date: 2018-05-26 pages: extension: .txt txt: ./txt/cord-017946-fa4ehlb0.txt cache: ./cache/cord-017946-fa4ehlb0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017946-fa4ehlb0.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 19233 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 86. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 86. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 84. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 27189 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18864 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 85. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 83. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 93. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 85. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-006869-g2q1gpp0 author: nan title: Neurocritical Care Society 7th Annual Meeting date: 2009-10-08 pages: extension: .txt txt: ./txt/cord-006869-g2q1gpp0.txt cache: ./cache/cord-006869-g2q1gpp0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006869-g2q1gpp0.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 85. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 86. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 31717 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-016960-xhzvp35g author: Berencsi, György title: Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy date: 2012-03-08 pages: extension: .txt txt: ./txt/cord-016960-xhzvp35g.txt cache: ./cache/cord-016960-xhzvp35g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-016960-xhzvp35g.txt' /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 82. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 31789 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 32173 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 84. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 29892 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 32249 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-010088-s9tfvtao author: nan title: Oral Abstracts date: 2013-11-01 pages: extension: .txt txt: ./txt/cord-010088-s9tfvtao.txt cache: ./cache/cord-010088-s9tfvtao.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-010088-s9tfvtao.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-016372-opojt70e author: DiMarco, Ross F. title: Postoperative Care of the Cardiac Surgical Patient date: 2010 pages: extension: .txt txt: ./txt/cord-016372-opojt70e.txt cache: ./cache/cord-016372-opojt70e.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016372-opojt70e.txt' === file2bib.sh === id: cord-018907-c84t1bo5 author: Bin-Hussain, Ibrahim title: Infections in the Immunocompromised Host date: 2012 pages: extension: .txt txt: ./txt/cord-018907-c84t1bo5.txt cache: ./cache/cord-018907-c84t1bo5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018907-c84t1bo5.txt' === file2bib.sh === id: cord-018447-z4jyjczy author: D’Cruz, David P. title: Antiphospholipid (Hughes) Syndrome: An Overview date: 2006 pages: extension: .txt txt: ./txt/cord-018447-z4jyjczy.txt cache: ./cache/cord-018447-z4jyjczy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-018447-z4jyjczy.txt' === file2bib.sh === id: cord-018225-dozmy3lb author: Hawker, Felicity H. title: The liver in critical illness date: 2008 pages: extension: .txt txt: ./txt/cord-018225-dozmy3lb.txt cache: ./cache/cord-018225-dozmy3lb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018225-dozmy3lb.txt' === file2bib.sh === id: cord-019046-q6uv2ayi author: Hughes, Amy L. title: Laryngeal Infections date: 2015-07-14 pages: extension: .txt txt: ./txt/cord-019046-q6uv2ayi.txt cache: ./cache/cord-019046-q6uv2ayi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-019046-q6uv2ayi.txt' === file2bib.sh === id: cord-018623-of9vx7og author: Saghazadeh, Amene title: The Physical Burden of Immunoperception date: 2019-04-27 pages: extension: .txt txt: ./txt/cord-018623-of9vx7og.txt cache: ./cache/cord-018623-of9vx7og.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018623-of9vx7og.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 83. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 84. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 85. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 84. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 81. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 78023 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 33562 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-018303-dvuwhpyq author: Garibaldi, Brian T. title: Aeromedical Evacuation of Patients with Contagious Infections date: 2019-02-27 pages: extension: .txt txt: ./txt/cord-018303-dvuwhpyq.txt cache: ./cache/cord-018303-dvuwhpyq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018303-dvuwhpyq.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-018412-kv3vxmcw author: Bambi, Stefano title: Evolution of Intensive Care Unit Nursing date: 2017-10-06 pages: extension: .txt txt: ./txt/cord-018412-kv3vxmcw.txt cache: ./cache/cord-018412-kv3vxmcw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-018412-kv3vxmcw.txt' === file2bib.sh === id: cord-018801-amet0wx4 author: Park, Caroline title: Care of the Patient with Liver Failure Requiring Transplantation date: 2018-05-04 pages: extension: .txt txt: ./txt/cord-018801-amet0wx4.txt cache: ./cache/cord-018801-amet0wx4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018801-amet0wx4.txt' === file2bib.sh === id: cord-018638-4pyjhpbk author: Pilania, Rakesh Kumar title: Kawasaki Disease date: 2019-10-30 pages: extension: .txt txt: ./txt/cord-018638-4pyjhpbk.txt cache: ./cache/cord-018638-4pyjhpbk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018638-4pyjhpbk.txt' === file2bib.sh === id: cord-019010-9xgwjvsv author: Luna, C. M. title: Life-threatening Respiratory Failure from H1N1 Influenza: Lessons from the Southern Cone Outbreak date: 2010-06-23 pages: extension: .txt txt: ./txt/cord-019010-9xgwjvsv.txt cache: ./cache/cord-019010-9xgwjvsv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-019010-9xgwjvsv.txt' === file2bib.sh === id: cord-017012-yl0vanuh author: Herberg, Jethro title: Infectious Diseases and the Kidney date: 2009 pages: extension: .txt txt: ./txt/cord-017012-yl0vanuh.txt cache: ./cache/cord-017012-yl0vanuh.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017012-yl0vanuh.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 38049 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 19622 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes id: cord-018780-zeok60hn author: Biddinger, Paul D. title: Evaluation of the Person Under Investigation date: 2018-07-07 pages: extension: .txt txt: ./txt/cord-018780-zeok60hn.txt cache: ./cache/cord-018780-zeok60hn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018780-zeok60hn.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-019968-o5bdb37q author: Goldwater, Paul N. title: Gastroenteritis in Auckland: An aetiological and clinical study date: 2005-04-14 pages: extension: .txt txt: ./txt/cord-019968-o5bdb37q.txt cache: ./cache/cord-019968-o5bdb37q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-019968-o5bdb37q.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-018454-sy21cpff author: Mitrovic, Stéphane title: Adult-Onset Still’s Disease date: 2019-10-30 pages: extension: .txt txt: ./txt/cord-018454-sy21cpff.txt cache: ./cache/cord-018454-sy21cpff.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018454-sy21cpff.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-018809-3nrvm4jt author: McMullin, N. R. title: Hemostatic Resuscitation date: 2006 pages: extension: .txt txt: ./txt/cord-018809-3nrvm4jt.txt cache: ./cache/cord-018809-3nrvm4jt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018809-3nrvm4jt.txt' === file2bib.sh === id: cord-018834-4ligp4ak author: Farag, Ehab title: The Perioperative Use of Albumin date: 2016-06-23 pages: extension: .txt txt: ./txt/cord-018834-4ligp4ak.txt cache: ./cache/cord-018834-4ligp4ak.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018834-4ligp4ak.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 84. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 83. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 83. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 82. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 81. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 82. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 83. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 80. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-017016-twwa9djm author: Tomashefski, Joseph F. title: Aspiration, Bronchial Obstruction, Bronchiectasis, and Related Disorders date: 2008 pages: extension: .txt txt: ./txt/cord-017016-twwa9djm.txt cache: ./cache/cord-017016-twwa9djm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017016-twwa9djm.txt' /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-020342-u8jzmloq author: nan title: Index to volume 42, January–June 2003() date: 2003-11-20 pages: extension: .txt txt: ./txt/cord-020342-u8jzmloq.txt cache: ./cache/cord-020342-u8jzmloq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-020342-u8jzmloq.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-018620-3kqx8arn author: Rueda, Mario title: Hepatic Failure date: 2016-10-09 pages: extension: .txt txt: ./txt/cord-018620-3kqx8arn.txt cache: ./cache/cord-018620-3kqx8arn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018620-3kqx8arn.txt' /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-021701-yan5q2r7 author: Woolard, Robert H. title: Emergency Department Design date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-021701-yan5q2r7.txt cache: ./cache/cord-021701-yan5q2r7.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-021701-yan5q2r7.txt' === file2bib.sh === id: cord-005487-vac061r8 author: nan title: Physicians Abstracts: EBMT 2010 date: 2010-04-07 pages: extension: .txt txt: ./txt/cord-005487-vac061r8.txt cache: ./cache/cord-005487-vac061r8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-005487-vac061r8.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 82. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 79. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 82. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 80. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 45913 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 81. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 81. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 78. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 81. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 80. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 79. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 80. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-018545-fk17n2bx author: Dorofaeff, Tavey title: Infections in the PICU date: 2012 pages: extension: .txt txt: ./txt/cord-018545-fk17n2bx.txt cache: ./cache/cord-018545-fk17n2bx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018545-fk17n2bx.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 78. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 77. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 79. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 79. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-022050-h24f0fpd author: Naughton, Matthew T. title: Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Asthma date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-022050-h24f0fpd.txt cache: ./cache/cord-022050-h24f0fpd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022050-h24f0fpd.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-018110-mcw4v13c author: Arnold, Andreas title: Inner Ear date: 2010 pages: extension: .txt txt: ./txt/cord-018110-mcw4v13c.txt cache: ./cache/cord-018110-mcw4v13c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018110-mcw4v13c.txt' === file2bib.sh === id: cord-021917-z9wpjr0d author: Stephens, R. Scott title: Bioterrorism and the Intensive Care Unit date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-021917-z9wpjr0d.txt cache: ./cache/cord-021917-z9wpjr0d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-021917-z9wpjr0d.txt' === file2bib.sh === id: cord-019043-cqmqwl3i author: Fidalgo, Pedro title: Chronic Kidney Disease in the Intensive Care Unit date: 2014-03-08 pages: extension: .txt txt: ./txt/cord-019043-cqmqwl3i.txt cache: ./cache/cord-019043-cqmqwl3i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-019043-cqmqwl3i.txt' === file2bib.sh === id: cord-021713-e0hzcag6 author: nan title: Ribavirin date: 2015-10-21 pages: extension: .txt txt: ./txt/cord-021713-e0hzcag6.txt cache: ./cache/cord-021713-e0hzcag6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-021713-e0hzcag6.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 77. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 80. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 51180 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 76. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 78. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-021816-gk8rwyq4 author: Weinberger, Steven E. title: Pneumonia date: 2018-02-22 pages: extension: .txt txt: ./txt/cord-021816-gk8rwyq4.txt cache: ./cache/cord-021816-gk8rwyq4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-021816-gk8rwyq4.txt' === file2bib.sh === id: cord-021905-fjcks7w4 author: Win, Patrick H. title: Asthma Triggers: What Really Matters? date: 2009-05-22 pages: extension: .txt txt: ./txt/cord-021905-fjcks7w4.txt cache: ./cache/cord-021905-fjcks7w4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-021905-fjcks7w4.txt' === file2bib.sh === id: cord-023622-tul7bonh author: nan title: Rotaviruses of Man and Animals date: 1975-02-01 pages: extension: .txt txt: ./txt/cord-023622-tul7bonh.txt cache: ./cache/cord-023622-tul7bonh.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023622-tul7bonh.txt' === file2bib.sh === id: cord-017309-pt27efu1 author: Gupta, G. S. title: Selectins and Associated Adhesion Proteins in Inflammatory disorders date: 2012-03-20 pages: extension: .txt txt: ./txt/cord-017309-pt27efu1.txt cache: ./cache/cord-017309-pt27efu1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017309-pt27efu1.txt' === file2bib.sh === id: cord-022119-bzd9e1q6 author: Orzell, Susannah title: Pharyngitis and Pharyngeal Space Infections: fever, sore throat, difficulty swallowing date: 2018-10-15 pages: extension: .txt txt: ./txt/cord-022119-bzd9e1q6.txt cache: ./cache/cord-022119-bzd9e1q6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022119-bzd9e1q6.txt' === file2bib.sh === id: cord-023169-obupqcua author: Chierakul, Wirongrong title: Leptospirosis date: 2013-10-21 pages: extension: .txt txt: ./txt/cord-023169-obupqcua.txt cache: ./cache/cord-023169-obupqcua.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023169-obupqcua.txt' === file2bib.sh === id: cord-022173-kb6mez61 author: Calvillo Batllés, P. title: Hematologic neoplasms: Interpreting lung findings in chest computed tomography() date: 2015-11-06 pages: extension: .txt txt: ./txt/cord-022173-kb6mez61.txt cache: ./cache/cord-022173-kb6mez61.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022173-kb6mez61.txt' === file2bib.sh === id: cord-018363-qr1pk78u author: Casey, Ashley title: Consultative and Comanagement date: 2015-10-10 pages: extension: .txt txt: ./txt/cord-018363-qr1pk78u.txt cache: ./cache/cord-018363-qr1pk78u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018363-qr1pk78u.txt' === file2bib.sh === id: cord-024233-hrzpxdh0 author: nan title: In This Issue/Research Watch/News in Brief date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-024233-hrzpxdh0.txt cache: ./cache/cord-024233-hrzpxdh0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-024233-hrzpxdh0.txt' === file2bib.sh === id: cord-022216-k4pi30sd author: Kliegman, Robert M. title: Neonatal necrotizing enterocolitis date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-022216-k4pi30sd.txt cache: ./cache/cord-022216-k4pi30sd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-022216-k4pi30sd.txt' === file2bib.sh === id: cord-018595-x3tleomb author: Dodiuk-Gad, Roni P. title: Adverse Medication Reactions date: 2017-04-25 pages: extension: .txt txt: ./txt/cord-018595-x3tleomb.txt cache: ./cache/cord-018595-x3tleomb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018595-x3tleomb.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 75. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 78. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 74. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 79. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 77. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 76. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58070 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 77. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 73. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 75. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 76. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 92. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 78. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 74. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 75. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 77. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 19423 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 76. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 91. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 72. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 73. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 59487 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 74. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 75. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 76. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-023873-fidpskcs author: Meersseman, Wouter title: Invasive Aspergillosis in the Intensive Care Unit: Beyond the Typical Haematological Patient date: 2009-05-04 pages: extension: .txt txt: ./txt/cord-023873-fidpskcs.txt cache: ./cache/cord-023873-fidpskcs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-023873-fidpskcs.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-022103-4zk8i6qb author: Siegel, Jane D. title: Pediatric Healthcare Epidemiology date: 2017-07-18 pages: extension: .txt txt: ./txt/cord-022103-4zk8i6qb.txt cache: ./cache/cord-022103-4zk8i6qb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-022103-4zk8i6qb.txt' === file2bib.sh === id: cord-024130-kgzegwon author: Ankita title: COVID-19: An Ophthalmological Update date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-024130-kgzegwon.txt cache: ./cache/cord-024130-kgzegwon.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-024130-kgzegwon.txt' === file2bib.sh === id: cord-023669-3ataw6gy author: Masur, Henry title: Critically Ill Immunosuppressed Host date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-023669-3ataw6gy.txt cache: ./cache/cord-023669-3ataw6gy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023669-3ataw6gy.txt' === file2bib.sh === id: cord-022658-mq91h15t author: nan title: Executive summary date: 2008-12-30 pages: extension: .txt txt: ./txt/cord-022658-mq91h15t.txt cache: ./cache/cord-022658-mq91h15t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-022658-mq91h15t.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 65496 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 74. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 71. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 75. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 73. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes === file2bib.sh === id: cord-018430-u3k8pds6 author: Mason, Jay W. title: Myocarditis date: 2007 pages: extension: .txt txt: ./txt/cord-018430-u3k8pds6.txt cache: ./cache/cord-018430-u3k8pds6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018430-u3k8pds6.txt' === file2bib.sh === id: cord-022521-r72jtoso author: Miller, Tracie L. title: Gastrointestinal Complications of Secondary Immunodeficiency Syndromes date: 2010-12-27 pages: extension: .txt txt: ./txt/cord-022521-r72jtoso.txt cache: ./cache/cord-022521-r72jtoso.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022521-r72jtoso.txt' === file2bib.sh === id: cord-024956-oht0v33s author: Yu, Minhua title: Thin-section Chest CT Imaging of Coronavirus Disease 2019 Pneumonia: Comparison Between Patients with Mild and Severe Disease date: 2020-04-23 pages: extension: .txt txt: ./txt/cord-024956-oht0v33s.txt cache: ./cache/cord-024956-oht0v33s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-024956-oht0v33s.txt' === file2bib.sh === id: cord-024073-243addff author: Richards, Guy title: COVID-19 and the Rationale for Pharmacotherapy: A South African Perspective date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-024073-243addff.txt cache: ./cache/cord-024073-243addff.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-024073-243addff.txt' === file2bib.sh === id: cord-024120-3eemj37r author: Schiff, Gordon D. title: An Interview with Gordon D. Schiff date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-024120-3eemj37r.txt cache: ./cache/cord-024120-3eemj37r.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-024120-3eemj37r.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 51276 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 72. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 74. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53882 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 71. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 72. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52017 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 70. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 71. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 73. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 73. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 69. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-024614-6bu3zo01 author: Tang, Daxing title: Prevention and control strategies for emergency, limited-term, and elective operations in pediatric surgery during the epidemic period of COVID-19 date: 2020-03-26 pages: extension: .txt txt: ./txt/cord-024614-6bu3zo01.txt cache: ./cache/cord-024614-6bu3zo01.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-024614-6bu3zo01.txt' === file2bib.sh === id: cord-023833-xpfibjh2 author: Kilickaya, O. title: Structured Approach to Early Recognition and Treatment of Acute Critical Illness date: 2014 pages: extension: .txt txt: ./txt/cord-023833-xpfibjh2.txt cache: ./cache/cord-023833-xpfibjh2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023833-xpfibjh2.txt' /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-018601-mk66097y author: Michelakis, Evangelos D. title: Pulmonary Arterial Hypertension date: 2007 pages: extension: .txt txt: ./txt/cord-018601-mk66097y.txt cache: ./cache/cord-018601-mk66097y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018601-mk66097y.txt' === file2bib.sh === id: cord-005478-5iu38pr6 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date: 2019-07-03 pages: extension: .txt txt: ./txt/cord-005478-5iu38pr6.txt cache: ./cache/cord-005478-5iu38pr6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-005478-5iu38pr6.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 70. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 68. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 70. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 69. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 72. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 68. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 72. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 71. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 67. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55373 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 67. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 69. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 90. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 70663 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 66. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 71. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 66. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 70. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 68. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 65. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-018714-i291z2ju author: Criado, Paulo Ricardo title: Adverse Drug Reactions date: 2016-12-31 pages: extension: .txt txt: ./txt/cord-018714-i291z2ju.txt cache: ./cache/cord-018714-i291z2ju.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018714-i291z2ju.txt' /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 65. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 70. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 64. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 67. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-025157-7b3v5yct author: Darreau, C. title: Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-025157-7b3v5yct.txt cache: ./cache/cord-025157-7b3v5yct.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-025157-7b3v5yct.txt' === file2bib.sh === id: cord-023186-gqltd6u0 author: nan title: Poster Sessions date: 2019-06-27 pages: extension: .txt txt: ./txt/cord-023186-gqltd6u0.txt cache: ./cache/cord-023186-gqltd6u0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023186-gqltd6u0.txt' === file2bib.sh === id: cord-025666-u8w4sk07 author: Edgar, DW title: Seeding the value based health care and standardised measurement of quality of life after burn debate date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-025666-u8w4sk07.txt cache: ./cache/cord-025666-u8w4sk07.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-025666-u8w4sk07.txt' /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-023033-tgt69ir6 author: nan title: Poster Session (pp. 78A–178A) date: 2006-02-10 pages: extension: .txt txt: ./txt/cord-023033-tgt69ir6.txt cache: ./cache/cord-023033-tgt69ir6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023033-tgt69ir6.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-022646-f7qs1obg author: Frey, Noelle V. title: Hematopoietic stem cell transplantation: ASBMT/CIBMTR 2010 tandem meeting highlights and discussion date: 2010-04-27 pages: extension: .txt txt: ./txt/cord-022646-f7qs1obg.txt cache: ./cache/cord-022646-f7qs1obg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-022646-f7qs1obg.txt' === file2bib.sh === id: cord-021571-7kbq0v9w author: Heath, Joan A. title: Infections Acquired in the Nursery: Epidemiology and Control date: 2009-05-19 pages: extension: .txt txt: ./txt/cord-021571-7kbq0v9w.txt cache: ./cache/cord-021571-7kbq0v9w.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-021571-7kbq0v9w.txt' === file2bib.sh === id: cord-026846-3u3x52f8 author: nan title: Inside This Issue date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-026846-3u3x52f8.txt cache: ./cache/cord-026846-3u3x52f8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-026846-3u3x52f8.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 77401 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 69. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 66. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 pages: extension: .txt txt: ./txt/cord-005646-xhx9pzhj.txt cache: ./cache/cord-005646-xhx9pzhj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-005646-xhx9pzhj.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-005777-6rvfsx4p author: nan title: PS 0420-0716 date: 2007-08-25 pages: extension: .txt txt: ./txt/cord-005777-6rvfsx4p.txt cache: ./cache/cord-005777-6rvfsx4p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-005777-6rvfsx4p.txt' /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-023311-7wqdlha4 author: nan title: Oral Session date: 2010-11-24 pages: extension: .txt txt: ./txt/cord-023311-7wqdlha4.txt cache: ./cache/cord-023311-7wqdlha4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023311-7wqdlha4.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 80666 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 78552 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 63. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 64. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 81095 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 68. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 62. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 69. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes === file2bib.sh === id: cord-025172-qg3jxgch author: Covarrubias, Jose title: Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-025172-qg3jxgch.txt cache: ./cache/cord-025172-qg3jxgch.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-025172-qg3jxgch.txt' === file2bib.sh === id: cord-026879-gwzrdeb1 author: Zarrintan, Armin title: Rapidly progressive COVID-19 viral pneumonia: a report of two patients with a focus on imaging findings date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-026879-gwzrdeb1.txt cache: ./cache/cord-026879-gwzrdeb1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-026879-gwzrdeb1.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-005881-oswgjaxz author: nan title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 pages: extension: .txt txt: ./txt/cord-005881-oswgjaxz.txt cache: ./cache/cord-005881-oswgjaxz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-005881-oswgjaxz.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-027551-a92lv4sh author: Pinto, Eleonora title: QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-027551-a92lv4sh.txt cache: ./cache/cord-027551-a92lv4sh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-027551-a92lv4sh.txt' === file2bib.sh === id: cord-025176-f0frlpwh author: Coimbra, Raul title: Resuming elective surgical services in times of COVID-19 infection date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-025176-f0frlpwh.txt cache: ./cache/cord-025176-f0frlpwh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-025176-f0frlpwh.txt' === file2bib.sh === id: cord-015370-4jfgsic7 author: nan title: 55th Annual Meeting of the Austrian Society of Surgery: Graz, June 25—27, 2014 date: 2014-06-03 pages: extension: .txt txt: ./txt/cord-015370-4jfgsic7.txt cache: ./cache/cord-015370-4jfgsic7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-015370-4jfgsic7.txt' === file2bib.sh === id: cord-025990-nj4ah2yz author: Konca, Capan title: Susceptibility Patterns of Multidrug-Resistant Acinetobacter baumannii date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-025990-nj4ah2yz.txt cache: ./cache/cord-025990-nj4ah2yz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-025990-nj4ah2yz.txt' === file2bib.sh === id: cord-027266-jdti1pwa author: Derevitskii, Ilya V. title: The Atrial Fibrillation Risk Score for Hyperthyroidism Patients date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-027266-jdti1pwa.txt cache: ./cache/cord-027266-jdti1pwa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-027266-jdti1pwa.txt' === file2bib.sh === id: cord-026991-75sbxnsc author: Sultan, Omar Muayad title: Pulmonary ct manifestations of COVID-19: changes within 2 weeks duration from presentation date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-026991-75sbxnsc.txt cache: ./cache/cord-026991-75sbxnsc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-026991-75sbxnsc.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 63. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 61. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 84227 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 65. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 68. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 84691 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 85547 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-015334-8p124rwp author: nan title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 pages: extension: .txt txt: ./txt/cord-015334-8p124rwp.txt cache: ./cache/cord-015334-8p124rwp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-015334-8p124rwp.txt' === file2bib.sh === id: cord-026868-z9gozm2w author: Mohammad, Abeer title: “She’s dead!” – Nursing simulation practices: A discourse analysis approach date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-026868-z9gozm2w.txt cache: ./cache/cord-026868-z9gozm2w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-026868-z9gozm2w.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 67. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 60. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 67. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-026392-cvb44v5v author: Dahlberg, Jørgen title: Barriers and challenges in the process of including critically ill patients in clinical studies date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-026392-cvb44v5v.txt cache: ./cache/cord-026392-cvb44v5v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-026392-cvb44v5v.txt' /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-024833-e6vcf4un author: nan title: Forum date: 2019-12-19 pages: extension: .txt txt: ./txt/cord-024833-e6vcf4un.txt cache: ./cache/cord-024833-e6vcf4un.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-024833-e6vcf4un.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 87199 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 87377 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 66. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 62. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 59. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 65. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 66. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 64. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 95847 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 63. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 88380 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 88702 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 61. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 62. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 64. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 65. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 58. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-028557-68jypaaw author: Joshi, Jaiteerth R. title: COVSACK: an innovative portable isolated and safe COVID-19 sample collection kiosk with automatic disinfection date: 2020-07-05 pages: extension: .txt txt: ./txt/cord-028557-68jypaaw.txt cache: ./cache/cord-028557-68jypaaw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-028557-68jypaaw.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 64. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 63. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 60. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-022594-fx044gcd author: Pirko, Istvan title: Demyelinating Disorders of the Central Nervous System date: 2009-05-18 pages: extension: .txt txt: ./txt/cord-022594-fx044gcd.txt cache: ./cache/cord-022594-fx044gcd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022594-fx044gcd.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-025170-dtbm4ue1 author: Malbrain, Manu L. N. G. title: Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA) date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-025170-dtbm4ue1.txt cache: ./cache/cord-025170-dtbm4ue1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-025170-dtbm4ue1.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-027259-f4sgobcz author: Metsker, Oleg title: Stroke ICU Patient Mortality Day Prediction date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-027259-f4sgobcz.txt cache: ./cache/cord-027259-f4sgobcz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-027259-f4sgobcz.txt' /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-017184-1ewi3dka author: nan title: Primary Immunodeficiencies date: 2008 pages: extension: .txt txt: ./txt/cord-017184-1ewi3dka.txt cache: ./cache/cord-017184-1ewi3dka.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-017184-1ewi3dka.txt' === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes id: cord-025164-hqj22yxe author: Renew, J. Ross title: Neuromuscular blockade management in the critically Ill patient date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-025164-hqj22yxe.txt cache: ./cache/cord-025164-hqj22yxe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-025164-hqj22yxe.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 61. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 62. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 60. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 92314 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 92434 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-021075-8hba6au3 author: Ouallet, J.-C. title: Aspects cliniques, physiopathologiques, et thérapeutiques de la sclérose en plaques date: 2004-07-29 pages: extension: .txt txt: ./txt/cord-021075-8hba6au3.txt cache: ./cache/cord-021075-8hba6au3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-021075-8hba6au3.txt' /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-023306-3gdfo6vd author: nan title: TSANZ Oral Abstracts date: 2010-03-01 pages: extension: .txt txt: ./txt/cord-023306-3gdfo6vd.txt cache: ./cache/cord-023306-3gdfo6vd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023306-3gdfo6vd.txt' === file2bib.sh === id: cord-028907-m9psxg1f author: Li, Yi title: Extended antiplatelet therapy with clopidogrel alone versus clopidogrel plus aspirin after completion of 9- to 12-month dual antiplatelet therapy for ACS patients with both high bleeding and ischemic risk. Rationale and design of the OPT-BIRISK double blinded, placebo controlled randomized trial date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-028907-m9psxg1f.txt cache: ./cache/cord-028907-m9psxg1f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-028907-m9psxg1f.txt' === file2bib.sh === id: cord-029606-2z1tw4xo author: John, Janice title: Developing an Intensive Community Covid-19 Management Strategy: Helping Our Patients Access Patient-Centered Care across a Continuum of Covid-19 Disease Needs date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-029606-2z1tw4xo.txt cache: ./cache/cord-029606-2z1tw4xo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-029606-2z1tw4xo.txt' === file2bib.sh === id: cord-028590-rw0okd0p author: Westgarth, David title: What does the future hold for the workforce of tomorrow? date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-028590-rw0okd0p.txt cache: ./cache/cord-028590-rw0okd0p.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-028590-rw0okd0p.txt' === file2bib.sh === id: cord-027677-fc410vto author: GOULD, JANE M. title: Pharyngitis, Stomatitis, Peritonsillar, and Retropharyngeal Abscess date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-027677-fc410vto.txt cache: ./cache/cord-027677-fc410vto.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-027677-fc410vto.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 61. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 59. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 96790 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-029211-6o7qn2y2 author: nan title: Press review date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-029211-6o7qn2y2.txt cache: ./cache/cord-029211-6o7qn2y2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-029211-6o7qn2y2.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 57. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: Resource temporarily unavailable === file2bib.sh === id: cord-023288-sqr33y72 author: nan title: Paediatric SIG: Poster Session date: 2008-03-12 pages: extension: .txt txt: ./txt/cord-023288-sqr33y72.txt cache: ./cache/cord-023288-sqr33y72.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023288-sqr33y72.txt' === file2bib.sh === id: cord-029466-9sy6icrm author: Ramadan, Ahmad Riad title: Tales of a department: how the COVID-19 pandemic transformed Detroit’s Henry Ford Hospital, Department of Neurology—part I: the surge date: 2020-07-12 pages: extension: .txt txt: ./txt/cord-029466-9sy6icrm.txt cache: ./cache/cord-029466-9sy6icrm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-029466-9sy6icrm.txt' /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 63. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 46954 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-029615-x498xj3m author: Kim, Michelle Kang title: A Primer for Clinician Deployment to the Medicine Floors from an Epicenter of Covid-19 date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-029615-x498xj3m.txt cache: ./cache/cord-029615-x498xj3m.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-029615-x498xj3m.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 59. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 62. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 95745 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 60. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 58. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 56. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 58. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 55. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 59. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable parallel: Warning: No more processes: Decreasing number of running jobs to 61. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === id: cord-030256-muah207b author: Kapoor, Poonam Malhotra title: COVID-19 Thrombosis: An Unsolved Mystery date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-030256-muah207b.txt cache: ./cache/cord-030256-muah207b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-030256-muah207b.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 57. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/cordwrd2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-029848-dj5xqlz1 author: Mahajan, Vidushi title: Using Telemedicine During the COVID-19 Pandemic date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-029848-dj5xqlz1.txt cache: ./cache/cord-029848-dj5xqlz1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-029848-dj5xqlz1.txt' /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-023168-cd7adns8 author: Thachil, Jecko title: Haematological Diseases in the Tropics date: 2013-10-21 pages: extension: .txt txt: ./txt/cord-023168-cd7adns8.txt cache: ./cache/cord-023168-cd7adns8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023168-cd7adns8.txt' === file2bib.sh === id: cord-028285-n4dommet author: Weilongorska, Natasha L. title: COVID-19: What are the challenges for NHS surgery? date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-028285-n4dommet.txt cache: ./cache/cord-028285-n4dommet.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-028285-n4dommet.txt' === file2bib.sh === id: cord-023303-fxus38mp author: nan title: Lung Cancer/Bronchology SIGs: Combined Poster Session date: 2008-03-12 pages: extension: .txt txt: ./txt/cord-023303-fxus38mp.txt cache: ./cache/cord-023303-fxus38mp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023303-fxus38mp.txt' === file2bib.sh === id: cord-023302-p9pxz44a author: nan title: Cystic Fibrosis SIG: Poster Session date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023302-p9pxz44a.txt cache: ./cache/cord-023302-p9pxz44a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-023302-p9pxz44a.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 54. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 58. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 57. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 60. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 57575 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 56. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 95704 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2adr.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordent2carrel.sh: fork: retry: No child processes === file2bib.sh === id: cord-026653-094bk0t0 author: Gülsen, Askin title: Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events* date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-026653-094bk0t0.txt cache: ./cache/cord-026653-094bk0t0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-026653-094bk0t0.txt' === file2bib.sh === id: cord-030918-0w327dgj author: Praena Crespo, Manuel title: Patient-centered primary care pediatrics. Is a paradigm change needed?() date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-030918-0w327dgj.txt cache: ./cache/cord-030918-0w327dgj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-030918-0w327dgj.txt' === file2bib.sh === id: cord-023308-af5nihyi author: nan title: COPD SIG: Poster Session 2 date: 2008-03-12 pages: extension: .txt txt: ./txt/cord-023308-af5nihyi.txt cache: ./cache/cord-023308-af5nihyi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023308-af5nihyi.txt' === file2bib.sh === id: cord-029991-0sy417j0 author: Longhini, Federico title: Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-029991-0sy417j0.txt cache: ./cache/cord-029991-0sy417j0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-029991-0sy417j0.txt' === file2bib.sh === id: cord-029150-e242o2ml author: Du, Jiang title: Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-029150-e242o2ml.txt cache: ./cache/cord-029150-e242o2ml.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-029150-e242o2ml.txt' === file2bib.sh === id: cord-030254-eevqclsy author: Mehta, Chitra title: Management of Coronavirus 2019 date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-030254-eevqclsy.txt cache: ./cache/cord-030254-eevqclsy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-030254-eevqclsy.txt' === file2bib.sh === id: cord-023333-b7w9zrl6 author: nan title: Oeld/Population Health SIG: Poster Session date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023333-b7w9zrl6.txt cache: ./cache/cord-023333-b7w9zrl6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-023333-b7w9zrl6.txt' === file2bib.sh === id: cord-031130-xvkyt3l3 author: Moreno-Duarte, Ingrid title: Heparin Induced Thrombocytopenia for the Perioperative and Critical Care Clinician date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-031130-xvkyt3l3.txt cache: ./cache/cord-031130-xvkyt3l3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-031130-xvkyt3l3.txt' === file2bib.sh === id: cord-030149-hkpjnqm9 author: Fioratti, Iuri title: Strategies for a safe and assertive telerehabilitation practice date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-030149-hkpjnqm9.txt cache: ./cache/cord-030149-hkpjnqm9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-030149-hkpjnqm9.txt' === file2bib.sh === id: cord-029884-zl0uqmfi author: Horowitz, Robert K. title: MVP (Medical situation, Values and Plan): A memorable and useful model for all Serious Illness Conversations date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-029884-zl0uqmfi.txt cache: ./cache/cord-029884-zl0uqmfi.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-029884-zl0uqmfi.txt' === file2bib.sh === id: cord-031544-clzt6kyg author: Clavijo, Raul title: “Online” and “at-home” versus traditional models of health care: enhancing access or impeding optimal therapeutics? date: 2020-09-08 pages: extension: .txt txt: ./txt/cord-031544-clzt6kyg.txt cache: ./cache/cord-031544-clzt6kyg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-031544-clzt6kyg.txt' === file2bib.sh === id: cord-005480-yg7salqt author: nan title: Oral Sessions and Working Party date: 2008-03-26 pages: extension: .txt txt: ./txt/cord-005480-yg7salqt.txt cache: ./cache/cord-005480-yg7salqt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-005480-yg7salqt.txt' === file2bib.sh === id: cord-023314-rwjxk8v4 author: nan title: Asthma & Allergy SIG: Poster Session 1 date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023314-rwjxk8v4.txt cache: ./cache/cord-023314-rwjxk8v4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-023314-rwjxk8v4.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 11344 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 pages: extension: .txt txt: ./txt/cord-014538-6a2pviol.txt cache: ./cache/cord-014538-6a2pviol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-014538-6a2pviol.txt' === file2bib.sh === id: cord-030502-mvlib8ol author: Hatachi, Takeshi title: Early steroid pulse therapy among children with influenza virus-associated encephalopathy date: 2020-08-12 pages: extension: .txt txt: ./txt/cord-030502-mvlib8ol.txt cache: ./cache/cord-030502-mvlib8ol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-030502-mvlib8ol.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 12667 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 13634 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-032335-6c9gt7t9 author: Segrelles-Calvo, Gonzalo title: Therapeutic limitation in elderly patients: Reflections regarding COVID19() date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-032335-6c9gt7t9.txt cache: ./cache/cord-032335-6c9gt7t9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-032335-6c9gt7t9.txt' === file2bib.sh === id: cord-031129-wqkdug42 author: Carr, Zyad J. title: An Update on Systemic Sclerosis and its Perioperative Management date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-031129-wqkdug42.txt cache: ./cache/cord-031129-wqkdug42.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-031129-wqkdug42.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 13995 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-030897-c88tjrai author: Aljohani, Amal H. title: Clinical and Immunological Characterization of Combined Immunodeficiency Due to TFRC Mutation in Eight Patients date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-030897-c88tjrai.txt cache: ./cache/cord-030897-c88tjrai.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-030897-c88tjrai.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18576 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-014976-546zaoxn author: nan title: Publication only date: 2006-03-08 pages: extension: .txt txt: ./txt/cord-014976-546zaoxn.txt cache: ./cache/cord-014976-546zaoxn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-014976-546zaoxn.txt' === file2bib.sh === id: cord-031710-1xl2isee author: Andrei, Stefan title: Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia – case report date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-031710-1xl2isee.txt cache: ./cache/cord-031710-1xl2isee.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-031710-1xl2isee.txt' === file2bib.sh === id: cord-030962-2xem8inu author: Isea de la Viña, Jesus title: Lung cancer patients on the waiting list in the midst of the COVID-19 crisis: what do we do now?() date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-030962-2xem8inu.txt cache: ./cache/cord-030962-2xem8inu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-030962-2xem8inu.txt' === file2bib.sh === id: cord-024189-t7mbsr25 author: Weyand, Cornelia M. title: Vasculitides date: 2008 pages: extension: .txt txt: ./txt/cord-024189-t7mbsr25.txt cache: ./cache/cord-024189-t7mbsr25.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-024189-t7mbsr25.txt' === file2bib.sh === id: cord-030531-4uucx9ss author: Randremanana, Rindra Vatosoa title: An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-030531-4uucx9ss.txt cache: ./cache/cord-030531-4uucx9ss.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-030531-4uucx9ss.txt' === file2bib.sh === id: cord-033279-bcf9568a author: Vujaklija Brajković, Ana title: Utility of procalcitonin in a medical intensive care unit in Croatia date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-033279-bcf9568a.txt cache: ./cache/cord-033279-bcf9568a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-033279-bcf9568a.txt' === file2bib.sh === id: cord-030216-l38i06v2 author: Liao, Kuang-Ming title: Hospital costs and prognosis in end-stage renal disease patients receiving coronary artery bypass grafting date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-030216-l38i06v2.txt cache: ./cache/cord-030216-l38i06v2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-030216-l38i06v2.txt' === file2bib.sh === id: cord-029112-u507i0t0 author: Smith, Keisha title: A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-029112-u507i0t0.txt cache: ./cache/cord-029112-u507i0t0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-029112-u507i0t0.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 89. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 76277 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 15071 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-031256-4mxt501d author: Van Der Poorten, Marie-Line M. title: Non-irritating skin test concentrations for ceftazidime and aztreonam in patients with a documented beta-lactam allergy. date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-031256-4mxt501d.txt cache: ./cache/cord-031256-4mxt501d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-031256-4mxt501d.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 15522 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-032588-8bfl2qy1 author: nan title: 51. Jahrestagung der Österreichischen Gesellschaft für Innere Medizin date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-032588-8bfl2qy1.txt cache: ./cache/cord-032588-8bfl2qy1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-032588-8bfl2qy1.txt' === file2bib.sh === id: cord-033135-cxsmxk3b author: Palomo Cobos, Luis title: Chronicity and primary care in times of pandemic() date: 2020-10-03 pages: extension: .txt txt: ./txt/cord-033135-cxsmxk3b.txt cache: ./cache/cord-033135-cxsmxk3b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-033135-cxsmxk3b.txt' === file2bib.sh === id: cord-030380-okue1kso author: McWilliams, J. Michael title: Professionalism Revealed: Rethinking Quality Improvement in the Wake of a Pandemic date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-030380-okue1kso.txt cache: ./cache/cord-030380-okue1kso.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-030380-okue1kso.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 16447 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-032544-2yrqjw1o author: Haroon, Sabrina-Wong-Peixin title: Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-032544-2yrqjw1o.txt cache: ./cache/cord-032544-2yrqjw1o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-032544-2yrqjw1o.txt' === file2bib.sh === id: cord-031191-63xtga7h author: Barrios Espinosa, Cristian title: Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-031191-63xtga7h.txt cache: ./cache/cord-031191-63xtga7h.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-031191-63xtga7h.txt' === file2bib.sh === id: cord-023239-06a03o14 author: nan title: II. Topic Sessions date: 2016-06-10 pages: extension: .txt txt: ./txt/cord-023239-06a03o14.txt cache: ./cache/cord-023239-06a03o14.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023239-06a03o14.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 16710 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-030361-0tepkjdl author: Mohammed Abdul, Mubeen Khan title: Hepatitis C Virus in the Elderly in the Direct-Acting Antiviral Era: from Diagnosis to Cure date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-030361-0tepkjdl.txt cache: ./cache/cord-030361-0tepkjdl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-030361-0tepkjdl.txt' === file2bib.sh === id: cord-032928-m0awip9y author: Sobh, Eman title: Novel coronavirus disease 2019 (COVID-19) non-respiratory involvement date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-032928-m0awip9y.txt cache: ./cache/cord-032928-m0awip9y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-032928-m0awip9y.txt' === file2bib.sh === id: cord-031821-rywdkqcd author: Borregón Rivilla, Miguel title: Coronavirus infection in cancer patients, last update() date: 2020-09-12 pages: extension: .txt txt: ./txt/cord-031821-rywdkqcd.txt cache: ./cache/cord-031821-rywdkqcd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-031821-rywdkqcd.txt' === file2bib.sh === id: cord-033778-u2r0neyc author: Taban, EM title: Observational study of therapeutic bronchoscopy in critical hypoxaemic ventilated patients with COVID-19 at Mediclinic Midstream Private Hospital in Pretoria, South Africa date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-033778-u2r0neyc.txt cache: ./cache/cord-033778-u2r0neyc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-033778-u2r0neyc.txt' === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes id: cord-031734-5wnvuk2n author: Wichlas, F. title: War surgery in Afghanistan: a model for mass causalities in terror attacks? date: 2020-09-11 pages: extension: .txt txt: ./txt/cord-031734-5wnvuk2n.txt cache: ./cache/cord-031734-5wnvuk2n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-031734-5wnvuk2n.txt' === file2bib.sh === id: cord-033574-4y53ryoa author: Tashiro, Hiroki title: Biomarkers for Overweight in Adult-Onset Asthma date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-033574-4y53ryoa.txt cache: ./cache/cord-033574-4y53ryoa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-033574-4y53ryoa.txt' === file2bib.sh === id: cord-032392-ex3s8evv author: Matthews, Tamyra title: Single cases from multiple perspectives: a qualitative study comparing the experiences of patients, patients’ caregivers, surgeons, and nurses when bad news is delivered about cancer date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-032392-ex3s8evv.txt cache: ./cache/cord-032392-ex3s8evv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-032392-ex3s8evv.txt' === file2bib.sh === id: cord-031497-pp0p3en6 author: Rodríguez-Fuster, Alberto title: Tracheal trauma in the context of the current infection by COVID-19. About 2 cases() date: 2020-09-06 pages: extension: .txt txt: ./txt/cord-031497-pp0p3en6.txt cache: ./cache/cord-031497-pp0p3en6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-031497-pp0p3en6.txt' === file2bib.sh === id: cord-034257-kl2ccmz5 author: de Jonge, Jeroen C. title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date: 2020-10-26 pages: extension: .txt txt: ./txt/cord-034257-kl2ccmz5.txt cache: ./cache/cord-034257-kl2ccmz5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-034257-kl2ccmz5.txt' === file2bib.sh === id: cord-033019-4eo037jp author: Garnier, Marc title: Answer to the letter by Niño et al date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-033019-4eo037jp.txt cache: ./cache/cord-033019-4eo037jp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-033019-4eo037jp.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18814 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18670 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-030370-89n13hml author: Brown, Colin S. title: Ebola Virus Disease in the Obstetric Population date: 2019-04-11 pages: extension: .txt txt: ./txt/cord-030370-89n13hml.txt cache: ./cache/cord-030370-89n13hml.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-030370-89n13hml.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18466 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 19014 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-034303-kcu9guxa author: Laimoud, Mohamed title: The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-034303-kcu9guxa.txt cache: ./cache/cord-034303-kcu9guxa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-034303-kcu9guxa.txt' === file2bib.sh === id: cord-034286-m1c98nv7 author: Wijdicks, Eelco F. M. title: Communicating Neurocritical Illness: The Anatomy of Misunderstanding date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-034286-m1c98nv7.txt cache: ./cache/cord-034286-m1c98nv7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-034286-m1c98nv7.txt' === file2bib.sh === id: cord-034690-x8lkngra author: Ridge, Carole A title: Dual-Energy CT Pulmonary Angiography (DECTPA) Quantifies Vasculopathy in Severe COVID-19 Pneumonia date: 2020-10-29 pages: extension: .txt txt: ./txt/cord-034690-x8lkngra.txt cache: ./cache/cord-034690-x8lkngra.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-034690-x8lkngra.txt' === file2bib.sh === id: cord-032244-s7t5u9lf author: Valente, Serafina title: ANMCO POSITION PAPER: Considerations on in-hospital cardiological consultations and cardiology outpatient clinics during the COVID-19 pandemic date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-032244-s7t5u9lf.txt cache: ./cache/cord-032244-s7t5u9lf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-032244-s7t5u9lf.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 19251 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-002774-tpqsjjet author: nan title: Section II: Poster Sessions date: 2017-12-01 pages: extension: .txt txt: ./txt/cord-002774-tpqsjjet.txt cache: ./cache/cord-002774-tpqsjjet.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-002774-tpqsjjet.txt' === file2bib.sh === id: cord-103686-er8llst4 author: Carboni Bisso, I. title: Influenza season 2019: analysis of 143 hospitalized cases date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-103686-er8llst4.txt cache: ./cache/cord-103686-er8llst4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-103686-er8llst4.txt' === file2bib.sh === id: cord-006860-a3b8hyyr author: nan title: 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date: 1996 pages: extension: .txt txt: ./txt/cord-006860-a3b8hyyr.txt cache: ./cache/cord-006860-a3b8hyyr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-006860-a3b8hyyr.txt' === file2bib.sh === id: cord-032930-ohsh46l2 author: Liu, Priscila Menezes Ferri title: Hepatorenal syndrome in children: a review date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-032930-ohsh46l2.txt cache: ./cache/cord-032930-ohsh46l2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-032930-ohsh46l2.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 21054 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 20778 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-027860-s97hdhh6 author: Zeimet, Anthony title: Infectious Diseases date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-027860-s97hdhh6.txt cache: ./cache/cord-027860-s97hdhh6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-027860-s97hdhh6.txt' === file2bib.sh === id: cord-034746-uxhpufnv author: Nusshag, Christian title: Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date: 2020-11-05 pages: extension: .txt txt: ./txt/cord-034746-uxhpufnv.txt cache: ./cache/cord-034746-uxhpufnv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-034746-uxhpufnv.txt' === file2bib.sh === id: cord-035024-kx9jfssi author: Elmelhat, Ahmed title: Comparison between Prophylactic versus Therapeutic Doses of Low-Molecular-Weight Heparin in Severely Ill Coronavirus Disease 2019 Patients in Relation to Disease Progression and Outcome date: 2020-10-26 pages: extension: .txt txt: ./txt/cord-035024-kx9jfssi.txt cache: ./cache/cord-035024-kx9jfssi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-035024-kx9jfssi.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 21255 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-104055-47ren7ie author: Lutkenhoff, Evan S. title: EEG power spectra and subcortical pathology in chronic disorders of consciousness date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-104055-47ren7ie.txt cache: ./cache/cord-104055-47ren7ie.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-104055-47ren7ie.txt' === file2bib.sh === id: cord-102199-mc6zruyx author: Toksvang, Linea Natalie title: Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: a systematic review date: 2019-01-30 pages: extension: .txt txt: ./txt/cord-102199-mc6zruyx.txt cache: ./cache/cord-102199-mc6zruyx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-102199-mc6zruyx.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 22091 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 21914 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-104180-f3hoz9bu author: Kirk-Bayley, Justin title: Recently published papers: inflammation, elucidation, manipulation? date: 2003-07-03 pages: extension: .txt txt: ./txt/cord-104180-f3hoz9bu.txt cache: ./cache/cord-104180-f3hoz9bu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-104180-f3hoz9bu.txt' === file2bib.sh === id: cord-035067-ic843wr9 author: de Almeida, Joana Ferro Machado title: COVID-19 and the gastrointestinal tract: what do we already know? date: 2020-11-05 pages: extension: .txt txt: ./txt/cord-035067-ic843wr9.txt cache: ./cache/cord-035067-ic843wr9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-035067-ic843wr9.txt' === file2bib.sh === id: cord-102276-0a8hup5y author: Savage, R. S. title: Development and validation of multivariable machine learning algorithms to predict risk of cancer in symptomatic patients referred urgently from primary care date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-102276-0a8hup5y.txt cache: ./cache/cord-102276-0a8hup5y.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-102276-0a8hup5y.txt' === file2bib.sh === id: cord-034578-i9rdubix author: Vaschetto, Rosanna title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 pages: extension: .txt txt: ./txt/cord-034578-i9rdubix.txt cache: ./cache/cord-034578-i9rdubix.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-034578-i9rdubix.txt' === file2bib.sh === id: cord-035182-ax6v3ak5 author: Griebenow, Reinhard title: Outcomes in CME/CPD - Special Collection: How to make the “pyramid” a perpetuum mobile date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-035182-ax6v3ak5.txt cache: ./cache/cord-035182-ax6v3ak5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-035182-ax6v3ak5.txt' === file2bib.sh === id: cord-035026-2qcsfd87 author: Ugwueze, Chidiebere V. title: COVID-19 and Diabetes Mellitus: The Link and Clinical Implications date: 2020-10-23 pages: extension: .txt txt: ./txt/cord-035026-2qcsfd87.txt cache: ./cache/cord-035026-2qcsfd87.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-035026-2qcsfd87.txt' === file2bib.sh === id: cord-103214-3lz33pj3 author: Kortuem, S. O. title: The Role of the Emergency Department in Protecting the Hospital as a Critical Infrastructure in the Corona Pandemic Strategies and Experiences of a Rural Sole Acute-Care Clinic date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-103214-3lz33pj3.txt cache: ./cache/cord-103214-3lz33pj3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-103214-3lz33pj3.txt' === file2bib.sh === id: cord-034898-zjfhpum2 author: Patangi, Sanjay Orathi title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective date: 2020-11-07 pages: extension: .txt txt: ./txt/cord-034898-zjfhpum2.txt cache: ./cache/cord-034898-zjfhpum2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-034898-zjfhpum2.txt' === file2bib.sh === id: cord-005147-mvoq9vln author: nan title: Autorenregister date: 2017-02-23 pages: extension: .txt txt: ./txt/cord-005147-mvoq9vln.txt cache: ./cache/cord-005147-mvoq9vln.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-005147-mvoq9vln.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23017 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23277 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-022659-chwk2bs4 author: nan title: Abstracts: Poster session date: 2004-10-08 pages: extension: .txt txt: ./txt/cord-022659-chwk2bs4.txt cache: ./cache/cord-022659-chwk2bs4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-022659-chwk2bs4.txt' === file2bib.sh === id: cord-217201-lvefk7qx author: Wang, Yang title: Ontology-based annotation and analysis of COVID-19 phenotypes date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-217201-lvefk7qx.txt cache: ./cache/cord-217201-lvefk7qx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-217201-lvefk7qx.txt' === file2bib.sh === id: cord-104507-xx7t26rl author: Safari, Saeid title: Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Severe COVID-19 patients; a Narrative Review date: 2020-08-22 pages: extension: .txt txt: ./txt/cord-104507-xx7t26rl.txt cache: ./cache/cord-104507-xx7t26rl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-104507-xx7t26rl.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23795 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 17326 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-035396-lg7m9xzs author: Bains, Amarpreet S. title: Maintaining Throughput and Reducing Discharge Delays After Increasing Capacity During The Covid-19 Pandemic: A New York City Hospital’s Experience date: 2020-11-12 pages: extension: .txt txt: ./txt/cord-035396-lg7m9xzs.txt cache: ./cache/cord-035396-lg7m9xzs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-035396-lg7m9xzs.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23864 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-184194-zdxebonv author: Chen, Lichin title: Using Deep Learning and Explainable Artificial Intelligence in Patients' Choices of Hospital Levels date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-184194-zdxebonv.txt cache: ./cache/cord-184194-zdxebonv.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-184194-zdxebonv.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23853 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 24242 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 24283 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 24068 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 24668 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-252617-rqm0p19e author: Baker, Paul A. title: What’s inside the box? Or shall we think outside the box? date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-252617-rqm0p19e.txt cache: ./cache/cord-252617-rqm0p19e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-252617-rqm0p19e.txt' === file2bib.sh === id: cord-048343-nzk8m912 author: Milbrandt, Eric B title: Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics date: 2006-11-15 pages: extension: .txt txt: ./txt/cord-048343-nzk8m912.txt cache: ./cache/cord-048343-nzk8m912.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-048343-nzk8m912.txt' === file2bib.sh === id: cord-216974-0al3vdh1 author: Ravaud, Philippe title: Reconfiguring health services to reduce the workload of caregivers during the COVID-19 outbreak using an open-source scalable platform for remote digital monitoring and coordination of care in hospital Command Centres date: 2020-03-12 pages: extension: .txt txt: ./txt/cord-216974-0al3vdh1.txt cache: ./cache/cord-216974-0al3vdh1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-216974-0al3vdh1.txt' === file2bib.sh === id: cord-103807-x4hrwhkz author: Prokop, J. W. title: Viral Induced Genetics Revealed by Multi-Dimensional Precision Medicine Transcriptional Workflow date: 2020-04-06 pages: extension: .txt txt: ./txt/cord-103807-x4hrwhkz.txt cache: ./cache/cord-103807-x4hrwhkz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-103807-x4hrwhkz.txt' === file2bib.sh === id: cord-023509-tvqpv6fp author: Corrin, Bryan title: Occupational, environmental and iatrogenic lung disease date: 2011-03-02 pages: extension: .txt txt: ./txt/cord-023509-tvqpv6fp.txt cache: ./cache/cord-023509-tvqpv6fp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-023509-tvqpv6fp.txt' === file2bib.sh === id: cord-204125-fvd6d44c author: Chowdhury, Muhammad E. H. title: An early warning tool for predicting mortality risk of COVID-19 patients using machine learning date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-204125-fvd6d44c.txt cache: ./cache/cord-204125-fvd6d44c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-204125-fvd6d44c.txt' === file2bib.sh === id: cord-015348-qt0worsl author: nan title: Abstract date: 2010-07-30 pages: extension: .txt txt: ./txt/cord-015348-qt0worsl.txt cache: ./cache/cord-015348-qt0worsl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-015348-qt0worsl.txt' === file2bib.sh === id: cord-251957-luw8m3eq author: Griffin, Claire L. title: Aortic Disease in the Time of COVID: Repercussions on Patient Care at an Academic Aortic Center date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-251957-luw8m3eq.txt cache: ./cache/cord-251957-luw8m3eq.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-251957-luw8m3eq.txt' === file2bib.sh === id: cord-252473-i4pmux28 author: Rogers, Sharon title: Why can't I visit? The ethics of visitation restrictions – lessons learned from SARS date: 2004-08-31 pages: extension: .txt txt: ./txt/cord-252473-i4pmux28.txt cache: ./cache/cord-252473-i4pmux28.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252473-i4pmux28.txt' === file2bib.sh === id: cord-252013-ehyuflg3 author: Bozzani, Antonio title: ACUTE ARTERIAL AND DEEP VENOUS THROMBOEMBOLISM IN COVID-19 PATIENTS date: 2020-09-22 pages: extension: .txt txt: ./txt/cord-252013-ehyuflg3.txt cache: ./cache/cord-252013-ehyuflg3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252013-ehyuflg3.txt' === file2bib.sh === id: cord-252159-6t35bxwv author: Ferraù, F. title: What we have to know about corticosteroids use during Sars-Cov-2 infection date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-252159-6t35bxwv.txt cache: ./cache/cord-252159-6t35bxwv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252159-6t35bxwv.txt' === file2bib.sh === id: cord-252829-gn56tsz3 author: Higginson, Irene J. title: Associations between informal care costs, care quality, carer rewards, burden and subsequent grief: the international, access, rights and empowerment mortality follow-back study of the last 3 months of life (IARE I study) date: 2020-11-03 pages: extension: .txt txt: ./txt/cord-252829-gn56tsz3.txt cache: ./cache/cord-252829-gn56tsz3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-252829-gn56tsz3.txt' === file2bib.sh === id: cord-252284-cgdcsazr author: Zeng, Jia-Hui title: First case of COVID-19 complicated with fulminant myocarditis: a case report and insights date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-252284-cgdcsazr.txt cache: ./cache/cord-252284-cgdcsazr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252284-cgdcsazr.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26010 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-015306-us58wwmp author: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 pages: extension: .txt txt: ./txt/cord-015306-us58wwmp.txt cache: ./cache/cord-015306-us58wwmp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-015306-us58wwmp.txt' === file2bib.sh === id: cord-158252-l43ztxsl author: Pawlowski, Colin title: Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-158252-l43ztxsl.txt cache: ./cache/cord-158252-l43ztxsl.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-158252-l43ztxsl.txt' === file2bib.sh === id: cord-104404-ytszpa4c author: Baig, Muhammad Akbar title: The COVID-19 Intubation and Ventilation Pathway (CiVP); a Commentary date: 2020-03-25 pages: extension: .txt txt: ./txt/cord-104404-ytszpa4c.txt cache: ./cache/cord-104404-ytszpa4c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-104404-ytszpa4c.txt' === file2bib.sh === id: cord-034185-e0am7pa6 author: Piccioni, Federico title: Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date: 2020-10-23 pages: extension: .txt txt: ./txt/cord-034185-e0am7pa6.txt cache: ./cache/cord-034185-e0am7pa6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-034185-e0am7pa6.txt' === file2bib.sh === id: cord-252279-0gozdv43 author: Pal, Amit title: Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-252279-0gozdv43.txt cache: ./cache/cord-252279-0gozdv43.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-252279-0gozdv43.txt' === file2bib.sh === id: cord-103659-wpwfqhp2 author: Almqvist, J. title: Neurological manifestations of coronavirus infections: a systematic review date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-103659-wpwfqhp2.txt cache: ./cache/cord-103659-wpwfqhp2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-103659-wpwfqhp2.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26731 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26869 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-252452-wwkw1uyi author: Rossi, Rosario title: Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action date: 2020-10-03 pages: extension: .txt txt: ./txt/cord-252452-wwkw1uyi.txt cache: ./cache/cord-252452-wwkw1uyi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-252452-wwkw1uyi.txt' === file2bib.sh === id: cord-252085-8dq3gdo8 author: Kaisy, Dr. Maythem Abdulhassan Al title: Chest Drain Insertion following Pneumothorax due to CPR in a COVID – 19 Patient. date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-252085-8dq3gdo8.txt cache: ./cache/cord-252085-8dq3gdo8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252085-8dq3gdo8.txt' === file2bib.sh === id: cord-253168-b095rq5i author: Jiménez-Blanco Bravo, Marta title: Heart Failure in the Time of COVID-19 date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-253168-b095rq5i.txt cache: ./cache/cord-253168-b095rq5i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253168-b095rq5i.txt' === file2bib.sh === id: cord-252890-of29g89s author: Villarreal-Fernandez, Eduardo title: A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-252890-of29g89s.txt cache: ./cache/cord-252890-of29g89s.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-252890-of29g89s.txt' === file2bib.sh === id: cord-006880-9dgmdtj8 author: nan title: Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date: 2012-09-19 pages: extension: .txt txt: ./txt/cord-006880-9dgmdtj8.txt cache: ./cache/cord-006880-9dgmdtj8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006880-9dgmdtj8.txt' === file2bib.sh === id: cord-254269-x8vpnhd2 author: Hakim, Abraham A. title: Implications for the use of telehealth in surgical patients during the COVID-19 pandemic date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-254269-x8vpnhd2.txt cache: ./cache/cord-254269-x8vpnhd2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-254269-x8vpnhd2.txt' === file2bib.sh === id: cord-252981-hywvmdjb author: Lockey, Stephen D. title: What’s Important: What Is Our Role in the COVID-19 Pandemic? date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-252981-hywvmdjb.txt cache: ./cache/cord-252981-hywvmdjb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-252981-hywvmdjb.txt' === file2bib.sh === id: cord-253148-3t4o27xp author: Chow, Brian D.W. title: Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio date: 2008-09-19 pages: extension: .txt txt: ./txt/cord-253148-3t4o27xp.txt cache: ./cache/cord-253148-3t4o27xp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253148-3t4o27xp.txt' === file2bib.sh === id: cord-023216-avn8f2w3 author: nan title: Symposium summaries date: 2004-10-18 pages: extension: .txt txt: ./txt/cord-023216-avn8f2w3.txt cache: ./cache/cord-023216-avn8f2w3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-023216-avn8f2w3.txt' === file2bib.sh === id: cord-252531-i3b647wv author: Song, Zaiwei title: Hospital pharmacists’ pharmaceutical care for hospitalized patients with COVID-19: Recommendations and guidance from clinical experience date: 2020-04-03 pages: extension: .txt txt: ./txt/cord-252531-i3b647wv.txt cache: ./cache/cord-252531-i3b647wv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-252531-i3b647wv.txt' === file2bib.sh === id: cord-252699-0xw9xvox author: de Marcaida, Joy Antonelle title: Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) among Patients at a Movement Disorders Center date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-252699-0xw9xvox.txt cache: ./cache/cord-252699-0xw9xvox.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-252699-0xw9xvox.txt' === file2bib.sh === id: cord-252687-7084pfqm author: Szelenberger, Rafal title: Ischemic Stroke among the Symptoms Caused by the COVID-19 Infection date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-252687-7084pfqm.txt cache: ./cache/cord-252687-7084pfqm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-252687-7084pfqm.txt' === file2bib.sh === id: cord-252751-prock3co author: Kalligeros, Markos title: Remdesivir Use Compared to Supportive Care in Hospitalized Patients with Severe COVID-19: A Single-Center Experience date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-252751-prock3co.txt cache: ./cache/cord-252751-prock3co.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-252751-prock3co.txt' === file2bib.sh === id: cord-023913-pnjhi8cu author: Foreman, Stephen title: Broader Considerations of Medical and Dental Data Integration date: 2011-10-08 pages: extension: .txt txt: ./txt/cord-023913-pnjhi8cu.txt cache: ./cache/cord-023913-pnjhi8cu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023913-pnjhi8cu.txt' === file2bib.sh === id: cord-000843-e1bn79ui author: nan title: ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme date: 2011-03-01 pages: extension: .txt txt: ./txt/cord-000843-e1bn79ui.txt cache: ./cache/cord-000843-e1bn79ui.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-000843-e1bn79ui.txt' === file2bib.sh === id: cord-253456-u9num2o9 author: Zhang, Che title: Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-253456-u9num2o9.txt cache: ./cache/cord-253456-u9num2o9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-253456-u9num2o9.txt' === file2bib.sh === id: cord-253886-4b3i30hi author: Isakov, Alexander title: Transport and Management of Patients With Confirmed or Suspected Ebola Virus Disease date: 2015-05-21 pages: extension: .txt txt: ./txt/cord-253886-4b3i30hi.txt cache: ./cache/cord-253886-4b3i30hi.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253886-4b3i30hi.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 29412 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-254148-wc762p6v author: Prell, Tino title: Recommendations for Standards of Network Care for Patients with Parkinson’s Disease in Germany date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-254148-wc762p6v.txt cache: ./cache/cord-254148-wc762p6v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-254148-wc762p6v.txt' === file2bib.sh === id: cord-253189-uba6dy08 author: Walker, Katie title: The evidence base for scribes and the disruptions of COVID-19 date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-253189-uba6dy08.txt cache: ./cache/cord-253189-uba6dy08.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253189-uba6dy08.txt' === file2bib.sh === id: cord-253638-5f9ofdsc author: Alsaied, Tarek title: Coronavirus Disease 2019 (COVID‐19) Pandemic Implications in Pediatric and Adult Congenital Heart Disease date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-253638-5f9ofdsc.txt cache: ./cache/cord-253638-5f9ofdsc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253638-5f9ofdsc.txt' === file2bib.sh === id: cord-005816-i54q5gsu author: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 pages: extension: .txt txt: ./txt/cord-005816-i54q5gsu.txt cache: ./cache/cord-005816-i54q5gsu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-005816-i54q5gsu.txt' === file2bib.sh === id: cord-253417-ihi67m1u author: Paleri, Vinidh title: Rapid implementation of an evidence‐based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow‐up after treatment during the COVID‐19 pandemic: Model for international collaboration date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-253417-ihi67m1u.txt cache: ./cache/cord-253417-ihi67m1u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253417-ihi67m1u.txt' === file2bib.sh === id: cord-253962-ug7yflxh author: Huang, Dong title: A novel risk score to predict diagnosis with Coronavirus Disease 2019 (COVID‐19) in suspected patients: A retrospective, multi‐center, observational study date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-253962-ug7yflxh.txt cache: ./cache/cord-253962-ug7yflxh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253962-ug7yflxh.txt' === file2bib.sh === id: cord-253746-15w4gquq author: Goldman, Michel title: Reflections on the Collaborative Fight Against COVID-19 date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-253746-15w4gquq.txt cache: ./cache/cord-253746-15w4gquq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-253746-15w4gquq.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 30019 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 29860 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 30386 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-253402-6sgeraws author: Remuzzi, Andrea title: COVID-19 and Italy: what next? date: 2020-03-13 pages: extension: .txt txt: ./txt/cord-253402-6sgeraws.txt cache: ./cache/cord-253402-6sgeraws.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253402-6sgeraws.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 30127 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-252775-faxiem2w author: Tamagnini, Gabriele title: Cardiac surgery in the time of the novel coronavirus: Why we should think to a new normal date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-252775-faxiem2w.txt cache: ./cache/cord-252775-faxiem2w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252775-faxiem2w.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 30742 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-252243-ua2w6xki author: Cooper, Emily title: Diagnosis and Management of UTI in Primary Care Settings—A Qualitative Study to Inform a Diagnostic Quick Reference Tool for Women Under 65 Years date: 2020-09-07 pages: extension: .txt txt: ./txt/cord-252243-ua2w6xki.txt cache: ./cache/cord-252243-ua2w6xki.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252243-ua2w6xki.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 30475 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-255197-79yfslu1 author: Soo, Chun Ian title: Telehealth: “virtual” lifeline for home-ventilated patients during the COVID-19 pandemic date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-255197-79yfslu1.txt cache: ./cache/cord-255197-79yfslu1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-255197-79yfslu1.txt' === file2bib.sh === id: cord-253970-sbj869yy author: Agarwal, Amit title: Neurological emergencies associated with COVID-19: stroke and beyond date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-253970-sbj869yy.txt cache: ./cache/cord-253970-sbj869yy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-253970-sbj869yy.txt' === file2bib.sh === id: cord-253704-y0t30xw3 author: Lahiri, Durjoy title: COVID-19 Pandemic: A Neurological Perspective date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-253704-y0t30xw3.txt cache: ./cache/cord-253704-y0t30xw3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-253704-y0t30xw3.txt' === file2bib.sh === id: cord-254040-s3k51rkk author: Bombaci, Alessandro title: Telemedicine for management of patients with amyotrophic lateral sclerosis through COVID-19 tail date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-254040-s3k51rkk.txt cache: ./cache/cord-254040-s3k51rkk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-254040-s3k51rkk.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 31376 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-254428-n0uwy77g author: Zhao, Wen title: Clinical characteristics and durations of hospitalized patients with COVID-19 in Beijing: a retrospective cohort study date: 2020-03-17 pages: extension: .txt txt: ./txt/cord-254428-n0uwy77g.txt cache: ./cache/cord-254428-n0uwy77g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-254428-n0uwy77g.txt' === file2bib.sh === id: cord-253129-v5lck9l7 author: Kim, Kyeong Tae title: Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial date: 2020-02-01 pages: extension: .txt txt: ./txt/cord-253129-v5lck9l7.txt cache: ./cache/cord-253129-v5lck9l7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253129-v5lck9l7.txt' === file2bib.sh === id: cord-006182-kck5e1ry author: nan title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date: 2019-10-01 pages: extension: .txt txt: ./txt/cord-006182-kck5e1ry.txt cache: ./cache/cord-006182-kck5e1ry.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-006182-kck5e1ry.txt' === file2bib.sh === id: cord-254990-nrzwn6oz author: Mayer, Kirby P. title: Recovery from COVID-19 and acute respiratory distress syndrome: the potential role of an intensive care unit recovery clinic: a case report date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-254990-nrzwn6oz.txt cache: ./cache/cord-254990-nrzwn6oz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-254990-nrzwn6oz.txt' === file2bib.sh === id: cord-030369-4dn02a35 author: Peng, Liang title: Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure) date: 2019-05-21 pages: extension: .txt txt: ./txt/cord-030369-4dn02a35.txt cache: ./cache/cord-030369-4dn02a35.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-030369-4dn02a35.txt' === file2bib.sh === id: cord-254478-scc9wee0 author: To, Kelvin Kai-Wang title: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study date: 2020-03-23 pages: extension: .txt txt: ./txt/cord-254478-scc9wee0.txt cache: ./cache/cord-254478-scc9wee0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 15 resourceName b'cord-254478-scc9wee0.txt' === file2bib.sh === id: cord-255300-btyth32l author: Kang, Swan title: Oculoplastic video-based telemedicine consultations: Covid-19 and beyond date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-255300-btyth32l.txt cache: ./cache/cord-255300-btyth32l.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-255300-btyth32l.txt' === file2bib.sh === id: cord-007890-bie1veti author: nan title: ECC-4 Abstracts date: 2002-04-16 pages: extension: .txt txt: ./txt/cord-007890-bie1veti.txt cache: ./cache/cord-007890-bie1veti.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-007890-bie1veti.txt' === file2bib.sh === id: cord-253730-cdkzvfib author: Suzuki, Emily title: Assessment of the Need for Early Initiation of Rehabilitation Treatments in Patients with Coronavirus Disease 2019 date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-253730-cdkzvfib.txt cache: ./cache/cord-253730-cdkzvfib.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253730-cdkzvfib.txt' === file2bib.sh === id: cord-255233-rvgj6pvk author: Munday, Molly-Rose title: A Pilot Study Examining Vitamin C Levels in Periodontal Patients date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-255233-rvgj6pvk.txt cache: ./cache/cord-255233-rvgj6pvk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-255233-rvgj6pvk.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 32258 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 32802 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-254446-yxqbe1dj author: Ren, Yunzhao R. title: A Comprehensive Updated Review on SARS‐CoV‐2 and COVID‐19 date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-254446-yxqbe1dj.txt cache: ./cache/cord-254446-yxqbe1dj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-254446-yxqbe1dj.txt' === file2bib.sh === id: cord-254357-5s84kimn author: Morse, Alan R title: Decreasing Avoidable Vision Loss: Identifying Antecedents of Adherence date: 2020-11-02 pages: extension: .txt txt: ./txt/cord-254357-5s84kimn.txt cache: ./cache/cord-254357-5s84kimn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-254357-5s84kimn.txt' === file2bib.sh === id: cord-254377-j8e8gb0l author: Ali, Sadaf title: Acute cor pulmonale from saddle pulmonary embolism in a patient with previous Covid-19 – should we prolong prophylactic anticoagulation? date: 2020-06-13 pages: extension: .txt txt: ./txt/cord-254377-j8e8gb0l.txt cache: ./cache/cord-254377-j8e8gb0l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-254377-j8e8gb0l.txt' === file2bib.sh === id: cord-254595-by2j7byz author: Rao, Sandesh S. title: Establishing Telemedicine in an Academic Total Joint Arthroplasty Practice: Needs and Opportunities Highlighted by the COVID-19 Pandemic date: 2020-04-23 pages: extension: .txt txt: ./txt/cord-254595-by2j7byz.txt cache: ./cache/cord-254595-by2j7byz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-254595-by2j7byz.txt' === file2bib.sh === id: cord-254993-bndl93qr author: Sonnweber, Thomas title: Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-254993-bndl93qr.txt cache: ./cache/cord-254993-bndl93qr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-254993-bndl93qr.txt' === file2bib.sh === id: cord-254382-xy8se56o author: Santos, C. title: Comparative Incidence and Outcomes of COVID-19 in Kidney or Kidney-Pancreas Transplant Recipients Versus Kidney or Kidney-Pancreas Waitlisted Patients: A Pilot Study date: 2020-07-25 pages: extension: .txt txt: ./txt/cord-254382-xy8se56o.txt cache: ./cache/cord-254382-xy8se56o.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-254382-xy8se56o.txt' === file2bib.sh === id: cord-254852-qr5gdmbc author: Grief, Samuel N. title: Guidelines for the Evaluation and Treatment of Pneumonia date: 2018-08-14 pages: extension: .txt txt: ./txt/cord-254852-qr5gdmbc.txt cache: ./cache/cord-254852-qr5gdmbc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-254852-qr5gdmbc.txt' === file2bib.sh === id: cord-256262-lwc4ghj2 author: Gangneux, Jean-Pierre title: Invasive fungal diseases during COVID-19: We should be prepared date: 2020-04-06 pages: extension: .txt txt: ./txt/cord-256262-lwc4ghj2.txt cache: ./cache/cord-256262-lwc4ghj2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-256262-lwc4ghj2.txt' === file2bib.sh === id: cord-255037-i9guxtix author: Reda, Gianluigi title: Reply to “CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report” Analysis of six hematological centers in Lombardy: On behalf of CLL commission of Lombardy Hematology Network (REL) date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-255037-i9guxtix.txt cache: ./cache/cord-255037-i9guxtix.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-255037-i9guxtix.txt' === file2bib.sh === id: cord-256109-dkp0fwe3 author: Mazzulli, Tony title: Severe Acute Respiratory Syndrome–associated Coronavirus in Lung Tissue date: 2004-01-17 pages: extension: .txt txt: ./txt/cord-256109-dkp0fwe3.txt cache: ./cache/cord-256109-dkp0fwe3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-256109-dkp0fwe3.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 33628 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-253295-82ydczid author: Funkhouser, William K. title: Pathology: the clinical description of human disease date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-253295-82ydczid.txt cache: ./cache/cord-253295-82ydczid.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253295-82ydczid.txt' === file2bib.sh === id: cord-256030-5xzuilc1 author: Michel, Pierre-Antoine title: Home hemodialysis during the COVID-19 epidemic: comment on the French experience from the viewpoint of a French home hemodialysis care network date: 2020-11-11 pages: extension: .txt txt: ./txt/cord-256030-5xzuilc1.txt cache: ./cache/cord-256030-5xzuilc1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-256030-5xzuilc1.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 33627 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-255831-nrc35tug author: Alviggi, Carlo title: COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-255831-nrc35tug.txt cache: ./cache/cord-255831-nrc35tug.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-255831-nrc35tug.txt' === file2bib.sh === id: cord-256011-0cr4ejxu author: de Castro-Hamoy, Leniza title: Age Matters but it should not be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID-19 date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-256011-0cr4ejxu.txt cache: ./cache/cord-256011-0cr4ejxu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-256011-0cr4ejxu.txt' === file2bib.sh === id: cord-254777-h8hw4m9f author: Tanner, Tamara title: Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19 date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-254777-h8hw4m9f.txt cache: ./cache/cord-254777-h8hw4m9f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-254777-h8hw4m9f.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 34445 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-257035-ob1xncbs author: Rigatelli, Gianluca title: Intubation and Ventilation amid COVID-19: Comment date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-257035-ob1xncbs.txt cache: ./cache/cord-257035-ob1xncbs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-257035-ob1xncbs.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 34499 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 34976 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-255435-mr239gai author: Sher, Yelizaveta title: A CASE REPORT OF COVID-19 ASSOCIATED HYPERACTIVE ICU DELIRIUM WITH PROPOSED PATHOPHYSIOLOGY AND TREATMENT date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-255435-mr239gai.txt cache: ./cache/cord-255435-mr239gai.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-255435-mr239gai.txt' === file2bib.sh === id: cord-256290-pyrmtps3 author: Kerr, Colm title: Prevalence of smell and taste dysfunction in a cohort of CoVID19 outpatients managed through remote consultation from a large urban teaching hospital in Dublin, Ireland date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-256290-pyrmtps3.txt cache: ./cache/cord-256290-pyrmtps3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-256290-pyrmtps3.txt' === file2bib.sh === id: cord-255807-7goz1agp author: Hak, E. title: Conventional Influenza Vaccination Is Not Associated with Complications in Working-Age Patients with Asthma or Chronic Obstructive Pulmonary Disease date: 2003-04-15 pages: extension: .txt txt: ./txt/cord-255807-7goz1agp.txt cache: ./cache/cord-255807-7goz1agp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-255807-7goz1agp.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 35721 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 35867 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-255652-3n2dxljj author: Challener, Douglas W. title: Screening for COVID-19: Patient factors predicting positive PCR test date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-255652-3n2dxljj.txt cache: ./cache/cord-255652-3n2dxljj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-255652-3n2dxljj.txt' === file2bib.sh === id: cord-022527-a0x6lws3 author: nan title: Eosinophils in Human Disease date: 2012-10-12 pages: extension: .txt txt: ./txt/cord-022527-a0x6lws3.txt cache: ./cache/cord-022527-a0x6lws3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-022527-a0x6lws3.txt' === file2bib.sh === id: cord-254494-wbfgrez1 author: Shi, Chunhong title: Barriers to Self-Management of Type 2 Diabetes During COVID-19 Medical Isolation: A Qualitative Study date: 2020-10-14 pages: extension: .txt txt: ./txt/cord-254494-wbfgrez1.txt cache: ./cache/cord-254494-wbfgrez1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-254494-wbfgrez1.txt' === file2bib.sh === id: cord-253862-jl1zhg13 author: Khalaf, Khalil title: SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-253862-jl1zhg13.txt cache: ./cache/cord-253862-jl1zhg13.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-253862-jl1zhg13.txt' === file2bib.sh === id: cord-256639-4e0irb6d author: Jean-Michel, Vanessa title: Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation date: 2020-09-06 pages: extension: .txt txt: ./txt/cord-256639-4e0irb6d.txt cache: ./cache/cord-256639-4e0irb6d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-256639-4e0irb6d.txt' === file2bib.sh === id: cord-256618-tt3p0tki author: Liao, Yun title: Role of pharmacists during the COVID‐19 pandemic in China ‐ Shanghai Experiences date: 2020-06-14 pages: extension: .txt txt: ./txt/cord-256618-tt3p0tki.txt cache: ./cache/cord-256618-tt3p0tki.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-256618-tt3p0tki.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 36025 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 36498 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-255805-wlr8nod3 author: Liu, Yan title: Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19: A case report date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-255805-wlr8nod3.txt cache: ./cache/cord-255805-wlr8nod3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-255805-wlr8nod3.txt' === file2bib.sh === id: cord-256535-fz5p2u6p author: Oki, Sogo title: Long-Term Clinical Outcome and Prognosis After Thrombectomy in Patients With Concomitant Malignancy date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-256535-fz5p2u6p.txt cache: ./cache/cord-256535-fz5p2u6p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-256535-fz5p2u6p.txt' === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 37109 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-256849-8w2avwo2 author: Koenig, Kristi L. title: Identify-Isolate-Inform: A Tool for Initial Detection and Management of Measles Patients in the Emergency Department date: 2015-03-18 pages: extension: .txt txt: ./txt/cord-256849-8w2avwo2.txt cache: ./cache/cord-256849-8w2avwo2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-256849-8w2avwo2.txt' === file2bib.sh === id: cord-256856-jw1d6uig author: Sohinki, Daniel title: What Coronavirus Disease 2019 Has Taught Us About Modern Electrophysiology Practice date: 2020-08-15 pages: extension: .txt txt: ./txt/cord-256856-jw1d6uig.txt cache: ./cache/cord-256856-jw1d6uig.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-256856-jw1d6uig.txt' === file2bib.sh === id: cord-256051-87alqfkd author: Revzin, Margarita V. title: Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-256051-87alqfkd.txt cache: ./cache/cord-256051-87alqfkd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-256051-87alqfkd.txt' === file2bib.sh === id: cord-256556-1zea3wa1 author: Lou, Yan title: Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial date: 2020-10-25 pages: extension: .txt txt: ./txt/cord-256556-1zea3wa1.txt cache: ./cache/cord-256556-1zea3wa1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-256556-1zea3wa1.txt' === file2bib.sh === id: cord-032183-yqqqe325 author: Ning, Qin title: Antiviral Therapy for AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 pages: extension: .txt txt: ./txt/cord-032183-yqqqe325.txt cache: ./cache/cord-032183-yqqqe325.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-032183-yqqqe325.txt' === file2bib.sh === id: cord-253077-61fmul8c author: Vabret, Nicolas title: Immunology of COVID-19: current state of the science date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-253077-61fmul8c.txt cache: ./cache/cord-253077-61fmul8c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-253077-61fmul8c.txt' === file2bib.sh === id: cord-256888-tdx12ccj author: Bradley, Benjamin T title: Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-256888-tdx12ccj.txt cache: ./cache/cord-256888-tdx12ccj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-256888-tdx12ccj.txt' === file2bib.sh === id: cord-257147-i48qljv6 author: Karakas, Mahir title: Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-257147-i48qljv6.txt cache: ./cache/cord-257147-i48qljv6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-257147-i48qljv6.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 37644 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 38154 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-258293-7q9zj8c2 author: Marini, Alessandra title: Letter to the Editor Regarding 'Coronavirus Disease 2019 (COVID-19) and Neurosurgery: Literature and Neurosurgical Societies Recommendations Update' date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-258293-7q9zj8c2.txt cache: ./cache/cord-258293-7q9zj8c2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-258293-7q9zj8c2.txt' === file2bib.sh === id: cord-255460-r5p5helx author: Aggarwal, Sadhna title: Drug repurposing for breast cancer therapy: Old weapon for new battle date: 2019-09-21 pages: extension: .txt txt: ./txt/cord-255460-r5p5helx.txt cache: ./cache/cord-255460-r5p5helx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-255460-r5p5helx.txt' === file2bib.sh === id: cord-257051-ntnfu5ns author: Tack, Christopher Topol title: “Physio Anywhere”: digitally-enhanced outpatient care as a legacy of coronavirus 2020 date: 2020-07-18 pages: extension: .txt txt: ./txt/cord-257051-ntnfu5ns.txt cache: ./cache/cord-257051-ntnfu5ns.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-257051-ntnfu5ns.txt' === file2bib.sh === id: cord-257206-av2k44ig author: Chen, Ruey title: Effects of a SARS prevention programme in Taiwan on nursing staff's anxiety, depression and sleep quality: A longitudinal survey date: 2006-02-28 pages: extension: .txt txt: ./txt/cord-257206-av2k44ig.txt cache: ./cache/cord-257206-av2k44ig.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-257206-av2k44ig.txt' === file2bib.sh === id: cord-256893-3sh87h2x author: Yang, Li title: COVID-19: immunopathogenesis and Immunotherapeutics date: 2020-07-25 pages: extension: .txt txt: ./txt/cord-256893-3sh87h2x.txt cache: ./cache/cord-256893-3sh87h2x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-256893-3sh87h2x.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 38951 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 38173 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-256508-ce59ovan author: Asselah, Tarik title: COVID-19: discovery, diagnostics and drug development date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-256508-ce59ovan.txt cache: ./cache/cord-256508-ce59ovan.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-256508-ce59ovan.txt' === file2bib.sh === id: cord-258416-1jrbu8ox author: Drenovska, Kossara title: Covid‐19 pandemic and the skin date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-258416-1jrbu8ox.txt cache: ./cache/cord-258416-1jrbu8ox.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258416-1jrbu8ox.txt' === file2bib.sh === id: cord-258067-par61wwh author: Di Martino, Marcello title: Elective Surgery During the SARS-CoV-2 Pandemic (COVID-19): A Morbimortality Analysis and Recommendations on Patient Prioritisation and Security Measures date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-258067-par61wwh.txt cache: ./cache/cord-258067-par61wwh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258067-par61wwh.txt' === file2bib.sh === id: cord-258278-25rhf91v author: Mowla, Ashkan title: Unusual Pattern of Arterial Macrothrombosis Causing Stroke in a Young Adult Recovered from COVID-19 date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-258278-25rhf91v.txt cache: ./cache/cord-258278-25rhf91v.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-258278-25rhf91v.txt' === file2bib.sh === id: cord-257839-kfzc4pwq author: Ferguson, Katie title: COVID-19 associated with extensive pulmonary arterial, intracardiac and peripheral arterial thrombosis date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-257839-kfzc4pwq.txt cache: ./cache/cord-257839-kfzc4pwq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-257839-kfzc4pwq.txt' === file2bib.sh === id: cord-258727-mhg56j20 author: Kolar, Dusan title: Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-258727-mhg56j20.txt cache: ./cache/cord-258727-mhg56j20.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-258727-mhg56j20.txt' === file2bib.sh === id: cord-257781-ybpliz32 author: Jones, Eben title: Subcutaneous Emphysema, Pneumomediastinum, and Pneumothorax in Critically Ill Patients With Coronavirus Disease 2019: A Retrospective Cohort Study date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-257781-ybpliz32.txt cache: ./cache/cord-257781-ybpliz32.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-257781-ybpliz32.txt' === file2bib.sh === id: cord-023017-k6edtg58 author: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 pages: extension: .txt txt: ./txt/cord-023017-k6edtg58.txt cache: ./cache/cord-023017-k6edtg58.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023017-k6edtg58.txt' === file2bib.sh === id: cord-258027-f3rr5el1 author: Østby, Anne‐Cathrine title: Respiratory virology and microbiology in intensive care units: a prospective cohort study date: 2013-05-18 pages: extension: .txt txt: ./txt/cord-258027-f3rr5el1.txt cache: ./cache/cord-258027-f3rr5el1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258027-f3rr5el1.txt' === file2bib.sh === id: cord-257309-sazs5wgh author: Ho, Hsi-en title: Clinical Outcomes and Features of Covid-19 in Patients with Primary Immunodeficiencies in New York City date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-257309-sazs5wgh.txt cache: ./cache/cord-257309-sazs5wgh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-257309-sazs5wgh.txt' === file2bib.sh === id: cord-257600-0plhquk9 author: Calles, Antonio title: Outcomes of COVID-19 in Patients With Lung Cancer Treated in a Tertiary Hospital in Madrid date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-257600-0plhquk9.txt cache: ./cache/cord-257600-0plhquk9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-257600-0plhquk9.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 37505 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-257344-d13at1y5 author: Ghasemiyeh, Parisa title: COVID-19 Outbreak: Challenges in Pharmacotherapy Based on Pharmacokinetic and Pharmacodynamic Aspects of Drug Therapy in Patients with Moderate to Severe Infection date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-257344-d13at1y5.txt cache: ./cache/cord-257344-d13at1y5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-257344-d13at1y5.txt' === file2bib.sh === id: cord-256634-gg8hptfg author: Rhodes, N. J. title: Multicenter point-prevalence evaluation of the utilization and safety of drug therapies for COVID-19 date: 2020-06-06 pages: extension: .txt txt: ./txt/cord-256634-gg8hptfg.txt cache: ./cache/cord-256634-gg8hptfg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-256634-gg8hptfg.txt' === file2bib.sh === id: cord-257467-b8o5ghvi author: Smith, Barbara A. title: Anesthesia as a Risk for Health Care Acquired Infections date: 2010-12-31 pages: extension: .txt txt: ./txt/cord-257467-b8o5ghvi.txt cache: ./cache/cord-257467-b8o5ghvi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-257467-b8o5ghvi.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 40174 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-257732-3xuy6tbn author: Azzi, Lorenzo title: Saliva is a reliable tool to detect SARS-CoV-2 date: 2020-04-14 pages: extension: .txt txt: ./txt/cord-257732-3xuy6tbn.txt cache: ./cache/cord-257732-3xuy6tbn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-257732-3xuy6tbn.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 40548 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-257717-fbfe5vt4 author: Wallis, Christopher J.D. title: The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-257717-fbfe5vt4.txt cache: ./cache/cord-257717-fbfe5vt4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-257717-fbfe5vt4.txt' === file2bib.sh === id: cord-257433-qgkwylmk author: Candeloro, Elisa title: An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-257433-qgkwylmk.txt cache: ./cache/cord-257433-qgkwylmk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-257433-qgkwylmk.txt' === file2bib.sh === id: cord-257336-rpx71ww5 author: Doukas, Sotirios G. title: E-cigarette or vaping induced lung injury: A case series and literature review date: 2020-10-03 pages: extension: .txt txt: ./txt/cord-257336-rpx71ww5.txt cache: ./cache/cord-257336-rpx71ww5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-257336-rpx71ww5.txt' === file2bib.sh === id: cord-258583-5qdthy0j author: Yan, He title: Multiple organ injury on admission predicts in‐hospital mortality in patients with COVID‐19 date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-258583-5qdthy0j.txt cache: ./cache/cord-258583-5qdthy0j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-258583-5qdthy0j.txt' === file2bib.sh === id: cord-258133-zsweppku author: Fischer, M. title: COVID-19 paranoia in a patient suffering from schizophrenic psychosis – a case report date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-258133-zsweppku.txt cache: ./cache/cord-258133-zsweppku.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258133-zsweppku.txt' === file2bib.sh === id: cord-258758-sz8chn5e author: Resch, Tim title: Atypical COVID -19 presentation in patient undergoing staged TAAA repair date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-258758-sz8chn5e.txt cache: ./cache/cord-258758-sz8chn5e.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-258758-sz8chn5e.txt' === file2bib.sh === id: cord-258315-yt1ytasw author: Kato, Hideaki title: Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-258315-yt1ytasw.txt cache: ./cache/cord-258315-yt1ytasw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258315-yt1ytasw.txt' === file2bib.sh === id: cord-259801-xuvcrvo2 author: Koch, Christian A. title: The Various Faces of Hyperthyroidism date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-259801-xuvcrvo2.txt cache: ./cache/cord-259801-xuvcrvo2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-259801-xuvcrvo2.txt' === file2bib.sh === id: cord-258888-amimzjee author: Ananth, Lakshmi title: Management of ENT Surgical Emergencies Amidst COVID-19 Lockdown: Our Experience in a Tertiary Referral Hospital date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-258888-amimzjee.txt cache: ./cache/cord-258888-amimzjee.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-258888-amimzjee.txt' === file2bib.sh === id: cord-258930-60yn4hg7 author: D’Amico, Ferdinando title: Inflammatory bowel diseases and COVID-19: the invisible enemy date: 2020-04-16 pages: extension: .txt txt: ./txt/cord-258930-60yn4hg7.txt cache: ./cache/cord-258930-60yn4hg7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258930-60yn4hg7.txt' === file2bib.sh === id: cord-258708-da6x5rxa author: Hafiane, Anouar title: SARS-CoV-2 and the cardiovascular system date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-258708-da6x5rxa.txt cache: ./cache/cord-258708-da6x5rxa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258708-da6x5rxa.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 41660 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 42381 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-259699-48jg7ci7 author: González-Calatayud, Dra Mariel title: Observational study of the suspected or confirmed cases of sars COV-2 infection needing emergency surgical intervention during the first months of the pandemic in a third level hospital: Case series date: 2020-10-24 pages: extension: .txt txt: ./txt/cord-259699-48jg7ci7.txt cache: ./cache/cord-259699-48jg7ci7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-259699-48jg7ci7.txt' === file2bib.sh === id: cord-258916-jbdz1pk0 author: Andreae, MH title: Data and Debriefing Observations on Healthcare Simulation to Prepare for the COVID-19 Pandemic: Healthcare Simulation for COVID-19 date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-258916-jbdz1pk0.txt cache: ./cache/cord-258916-jbdz1pk0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-258916-jbdz1pk0.txt' === file2bib.sh === id: cord-260456-kjmab3og author: Hegde, Shruti title: Massive Pulmonary Embolism Complicating Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report date: 2020-10-28 pages: extension: .txt txt: ./txt/cord-260456-kjmab3og.txt cache: ./cache/cord-260456-kjmab3og.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260456-kjmab3og.txt' === file2bib.sh === id: cord-258402-9s57thvn author: Dabas, Vineet title: Management of Orthopaedic Accidental Emergencies Amidst COVID-19 Pandemic: Our Experience in Preparing to Live with Corona date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-258402-9s57thvn.txt cache: ./cache/cord-258402-9s57thvn.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258402-9s57thvn.txt' === file2bib.sh === id: cord-259448-deya8dwn author: Li, Caixia title: Differential microRNA expression in the peripheral blood from human patients with COVID‐19 date: 2020-09-22 pages: extension: .txt txt: ./txt/cord-259448-deya8dwn.txt cache: ./cache/cord-259448-deya8dwn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-259448-deya8dwn.txt' === file2bib.sh === id: cord-259969-q65k590s author: Kösters, Katrin title: Cutaneous Vasculitis in a Patient With COVID-19 date: 2020-10-05 pages: extension: .txt txt: ./txt/cord-259969-q65k590s.txt cache: ./cache/cord-259969-q65k590s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-259969-q65k590s.txt' === file2bib.sh === id: cord-259204-27t269pd author: Grimaldi, D. title: Characteristics and outcomes of Acute Respiratory Distress Syndrome related to COVID-19 in Belgian and French Intensive Care Units according to antiviral strategies. The COVADIS multicenter observational study. date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-259204-27t269pd.txt cache: ./cache/cord-259204-27t269pd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-259204-27t269pd.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43075 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-258117-5gpo8smn author: Le Naour, Julie title: Trial watch: IDO inhibitors in cancer therapy date: 2020-06-14 pages: extension: .txt txt: ./txt/cord-258117-5gpo8smn.txt cache: ./cache/cord-258117-5gpo8smn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-258117-5gpo8smn.txt' === file2bib.sh === id: cord-255519-tcobane8 author: Bartels, Matthew N. title: Acute Medical Conditions: Cardiopulmonary Disease, Medical Frailty, and Renal Failure date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-255519-tcobane8.txt cache: ./cache/cord-255519-tcobane8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-255519-tcobane8.txt' === file2bib.sh === id: cord-259073-dixskemz author: Ward, Christine F. title: Altered Mental Status as a Novel Initial Clinical Presentation for COVID-19 Infection in the Elderly date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-259073-dixskemz.txt cache: ./cache/cord-259073-dixskemz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-259073-dixskemz.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43442 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43234 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-260083-c1r9zn43 author: Lucatelli, Pierleone title: Heparin-Related Major Bleeding in Covid-19-Positive Patient: Perspective from the Outbreak date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-260083-c1r9zn43.txt cache: ./cache/cord-260083-c1r9zn43.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-260083-c1r9zn43.txt' === file2bib.sh === id: cord-258128-qtmjgrml author: Mirjalili, Mahtabalsadat title: Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-258128-qtmjgrml.txt cache: ./cache/cord-258128-qtmjgrml.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258128-qtmjgrml.txt' === file2bib.sh === id: cord-259907-yqmi0cqy author: Maxwell, Cynthia title: Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) No. 225, April 2009 date: 2009-10-31 pages: extension: .txt txt: ./txt/cord-259907-yqmi0cqy.txt cache: ./cache/cord-259907-yqmi0cqy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-259907-yqmi0cqy.txt' parallel: Warning: No more processes: Decreasing number of running jobs to 88. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 44363 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-259585-mjtxiu0t author: Occhipinti, Vincenzo title: Challenges in the Care of IBD Patients During the CoViD-19 Pandemic: Report From a “Red Zone” Area in Northern Italy date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-259585-mjtxiu0t.txt cache: ./cache/cord-259585-mjtxiu0t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-259585-mjtxiu0t.txt' === file2bib.sh === id: cord-259747-sl9q63oc author: Remmelink, Myriam title: Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients date: 2020-08-12 pages: extension: .txt txt: ./txt/cord-259747-sl9q63oc.txt cache: ./cache/cord-259747-sl9q63oc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-259747-sl9q63oc.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 49495 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-259411-434acu0h author: Aljehani, Faisal A. title: Inpatient Diabetes and Hyperglycemia Management Protocol in the COVID-19 Era date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-259411-434acu0h.txt cache: ./cache/cord-259411-434acu0h.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-259411-434acu0h.txt' === file2bib.sh === id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-015024-2xzc0uc5.txt cache: ./cache/cord-015024-2xzc0uc5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-015024-2xzc0uc5.txt' === file2bib.sh === id: cord-260525-bohv78hi author: Mei, Yang title: Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-260525-bohv78hi.txt cache: ./cache/cord-260525-bohv78hi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260525-bohv78hi.txt' === file2bib.sh === id: cord-260630-vvpzp73r author: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 pages: extension: .txt txt: ./txt/cord-260630-vvpzp73r.txt cache: ./cache/cord-260630-vvpzp73r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260630-vvpzp73r.txt' === file2bib.sh === id: cord-260224-1aeqe7fh author: Passerini, Matteo title: Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-260224-1aeqe7fh.txt cache: ./cache/cord-260224-1aeqe7fh.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260224-1aeqe7fh.txt' === file2bib.sh === id: cord-261062-9zhe3ejy author: Zhu, Shu-Ting title: Utility of Point-of-Care Lung Ultrasound for Clinical Classification of COVID-19 date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-261062-9zhe3ejy.txt cache: ./cache/cord-261062-9zhe3ejy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261062-9zhe3ejy.txt' === file2bib.sh === id: cord-261006-2xh3f07i author: Dong, Zhiyong title: Recommendations to Manage Patients for Bariatric Surgery in the COVID-19 Pandemic: Experience from China date: 2020-06-06 pages: extension: .txt txt: ./txt/cord-261006-2xh3f07i.txt cache: ./cache/cord-261006-2xh3f07i.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261006-2xh3f07i.txt' === file2bib.sh === id: cord-260980-tyf3fuz9 author: Lorenzo Villalba, Noel title: Anosmia and Dysgeusia in the Absence of Other Respiratory Diseases: Should COVID-19 Infection Be Considered? date: 2020-04-03 pages: extension: .txt txt: ./txt/cord-260980-tyf3fuz9.txt cache: ./cache/cord-260980-tyf3fuz9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260980-tyf3fuz9.txt' === file2bib.sh === id: cord-260180-kojb8efv author: Elsoukkary, Sarah S. title: Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-260180-kojb8efv.txt cache: ./cache/cord-260180-kojb8efv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-260180-kojb8efv.txt' === file2bib.sh === id: cord-260503-yq4dtf8n author: SAMARANAYAKE, LAKSHMAN P. title: Severe acute respiratory syndrome and dentistry A retrospective view date: 2004-09-30 pages: extension: .txt txt: ./txt/cord-260503-yq4dtf8n.txt cache: ./cache/cord-260503-yq4dtf8n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260503-yq4dtf8n.txt' === file2bib.sh === id: cord-259329-8pta6o6a author: Haimovich, Adrian title: Development and validation of the quick COVID-19 severity index (qCSI): a prognostic tool for early clinical decompensation date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-259329-8pta6o6a.txt cache: ./cache/cord-259329-8pta6o6a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-259329-8pta6o6a.txt' === file2bib.sh === id: cord-260700-u12aa739 author: Kainulainen, Leena title: Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia date: 2010-06-10 pages: extension: .txt txt: ./txt/cord-260700-u12aa739.txt cache: ./cache/cord-260700-u12aa739.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260700-u12aa739.txt' === file2bib.sh === id: cord-261410-kb91eagd author: Park, Ji Young title: Clinical Features and Courses of Adenovirus Pneumonia in Healthy Young Adults during an Outbreak among Korean Military Personnel date: 2017-01-23 pages: extension: .txt txt: ./txt/cord-261410-kb91eagd.txt cache: ./cache/cord-261410-kb91eagd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-261410-kb91eagd.txt' === file2bib.sh === id: cord-260232-98gtlad6 author: Chenna, Avantika title: Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-260232-98gtlad6.txt cache: ./cache/cord-260232-98gtlad6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-260232-98gtlad6.txt' === file2bib.sh === id: cord-261383-izd1vn6f author: Oleynick, Christopher title: Symptoms of Pleurisy as the Initial Presentation of COVID-19 date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-261383-izd1vn6f.txt cache: ./cache/cord-261383-izd1vn6f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261383-izd1vn6f.txt' === file2bib.sh === id: cord-261801-va2e029z author: Hoffman, Pamela E. title: Rapidly scaling video visits during COVID-19: The ethos of virtual care at Yale Medicine date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-261801-va2e029z.txt cache: ./cache/cord-261801-va2e029z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261801-va2e029z.txt' === file2bib.sh === id: cord-261240-osbk041e author: Bermejo-Martin, Jesús F title: Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection date: 2020-03-05 pages: extension: .txt txt: ./txt/cord-261240-osbk041e.txt cache: ./cache/cord-261240-osbk041e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-261240-osbk041e.txt' === file2bib.sh === id: cord-011062-ukz4hnmy author: nan title: Poster date: 2020-03-11 pages: extension: .txt txt: ./txt/cord-011062-ukz4hnmy.txt cache: ./cache/cord-011062-ukz4hnmy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-011062-ukz4hnmy.txt' === file2bib.sh === id: cord-259229-e8m8m4ut author: Samidurai, Arun title: Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic Strategies date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-259229-e8m8m4ut.txt cache: ./cache/cord-259229-e8m8m4ut.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-259229-e8m8m4ut.txt' === file2bib.sh === id: cord-260871-dtn5t8ka author: Silva, Marcus Tulius T. title: SARS-CoV-2: Should We Be Concerned about the Nervous System? date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-260871-dtn5t8ka.txt cache: ./cache/cord-260871-dtn5t8ka.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-260871-dtn5t8ka.txt' === file2bib.sh === id: cord-260215-gsnjlhjd author: Dhanani, Jayesh title: Fundamentals of aerosol therapy in critical care date: 2016-10-07 pages: extension: .txt txt: ./txt/cord-260215-gsnjlhjd.txt cache: ./cache/cord-260215-gsnjlhjd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-260215-gsnjlhjd.txt' === file2bib.sh === id: cord-260679-tm1s6wvj author: Lim, Wei Shen title: Pneumonia—Overview date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-260679-tm1s6wvj.txt cache: ./cache/cord-260679-tm1s6wvj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260679-tm1s6wvj.txt' === file2bib.sh === id: cord-261921-c97ygxq2 author: Souders, Colby P. title: Considerations for Bedside Urologic Procedures in Patients with Severe Acute Respiratory Syndrome Coronavirus-2 date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-261921-c97ygxq2.txt cache: ./cache/cord-261921-c97ygxq2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261921-c97ygxq2.txt' === file2bib.sh === id: cord-261380-xms5su6w author: Rahmani, Hamid title: Interferon β-1b in treatment of severe COVID-19: a randomized clinical trial date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-261380-xms5su6w.txt cache: ./cache/cord-261380-xms5su6w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261380-xms5su6w.txt' === file2bib.sh === id: cord-261980-bm0benu2 author: Cox, Mougnyan title: Neuroendovascular Treatment of Acute Stroke during Covid-19: A Guide from the Frontlines date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-261980-bm0benu2.txt cache: ./cache/cord-261980-bm0benu2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261980-bm0benu2.txt' === file2bib.sh === id: cord-261025-y49su5uc author: Sampathkumar, Priya title: SARS: Epidemiology, Clinical Presentation, Management, and Infection Control Measures date: 2003-07-31 pages: extension: .txt txt: ./txt/cord-261025-y49su5uc.txt cache: ./cache/cord-261025-y49su5uc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261025-y49su5uc.txt' === file2bib.sh === id: cord-261246-m40kwgcg author: Chen, Nanshan title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study date: 2020-01-30 pages: extension: .txt txt: ./txt/cord-261246-m40kwgcg.txt cache: ./cache/cord-261246-m40kwgcg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261246-m40kwgcg.txt' === file2bib.sh === id: cord-258498-0mvxwo3w author: Shah, Saleha title: COVID-19 and paediatric dentistry- traversing the challenges. A narrative review date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-258498-0mvxwo3w.txt cache: ./cache/cord-258498-0mvxwo3w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-258498-0mvxwo3w.txt' === file2bib.sh === id: cord-261485-0ke5nqy0 author: Sabir, A. M. title: Effects of Anticoagulants and Corticosteroids therapy in patients affected by severe COVID-19 Pneumonia date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-261485-0ke5nqy0.txt cache: ./cache/cord-261485-0ke5nqy0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261485-0ke5nqy0.txt' === file2bib.sh === id: cord-261670-rd9uq6tc author: Stringer, Kathleen A. title: COVID‐19: The Uninvited Guest in the Intensive Care Unit — Implications for Pharmacotherapy date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-261670-rd9uq6tc.txt cache: ./cache/cord-261670-rd9uq6tc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-261670-rd9uq6tc.txt' === file2bib.sh === id: cord-260857-oxxle915 author: Samuel, Sharmeen title: INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc). date: 2020-07-01 pages: extension: .txt txt: ./txt/cord-260857-oxxle915.txt cache: ./cache/cord-260857-oxxle915.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-260857-oxxle915.txt' === file2bib.sh === id: cord-261470-sqxdwu6j author: Weichmann, Franziska title: Projected supportive effects of Pycnogenol® in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-261470-sqxdwu6j.txt cache: ./cache/cord-261470-sqxdwu6j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-261470-sqxdwu6j.txt' === file2bib.sh === id: cord-262068-9ixq8hwb author: Gottardi, Andrea De title: Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-262068-9ixq8hwb.txt cache: ./cache/cord-262068-9ixq8hwb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262068-9ixq8hwb.txt' === file2bib.sh === id: cord-261311-j6bmgmhz author: Parreiras Martins, Maria Auxiliadora title: Preparedness of pharmacists to respond to the emergency of the COVID-19 pandemic in Brazil: a comprehensive overview date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-261311-j6bmgmhz.txt cache: ./cache/cord-261311-j6bmgmhz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-261311-j6bmgmhz.txt' === file2bib.sh === id: cord-262339-e2ayh108 author: Bohner, Lauren title: 2019-nCoV: Measures Adopted at the Departments of Oral Surgery and Radiology during the Period of an Uncontrolled Transmission Increase date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-262339-e2ayh108.txt cache: ./cache/cord-262339-e2ayh108.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262339-e2ayh108.txt' === file2bib.sh === id: cord-262236-1lilrqts author: Capone, Stephen title: Characterization of Critically Ill COVID-19 Patients at a Brooklyn Safety-Net Hospital date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-262236-1lilrqts.txt cache: ./cache/cord-262236-1lilrqts.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-262236-1lilrqts.txt' === file2bib.sh === id: cord-259984-csdf1a69 author: Raffiq, Azman title: COVID-19 Pandemic and Its Impact on Neurosurgery Practice in Malaysia: Academic Insights, Clinical Experience and Protocols from March till August 2020 date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-259984-csdf1a69.txt cache: ./cache/cord-259984-csdf1a69.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-259984-csdf1a69.txt' === file2bib.sh === id: cord-261856-i1e0uj0s author: Heffner, John E title: Chronic obstructive pulmonary disease in geriatric critical care date: 2005-03-04 pages: extension: .txt txt: ./txt/cord-261856-i1e0uj0s.txt cache: ./cache/cord-261856-i1e0uj0s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261856-i1e0uj0s.txt' === file2bib.sh === id: cord-262626-yk4e737w author: Favaloro, Emmanuel J. title: Recommendations for Minimal Laboratory Testing Panels in Patients with COVID-19: Potential for Prognostic Monitoring date: 2020-04-12 pages: extension: .txt txt: ./txt/cord-262626-yk4e737w.txt cache: ./cache/cord-262626-yk4e737w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262626-yk4e737w.txt' === file2bib.sh === id: cord-261736-jlwctmxw author: Marchand, Geneviève title: Bacteria emitted in ambient air during bronchoscopy—a risk to health care workers? date: 2016-12-01 pages: extension: .txt txt: ./txt/cord-261736-jlwctmxw.txt cache: ./cache/cord-261736-jlwctmxw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261736-jlwctmxw.txt' === file2bib.sh === id: cord-260119-pgu2crhs author: Golledge, Jonathan title: The Potential Role of Sensors, Wearables and Telehealth in the Remote Management of Diabetes-Related Foot Disease date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-260119-pgu2crhs.txt cache: ./cache/cord-260119-pgu2crhs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-260119-pgu2crhs.txt' === file2bib.sh === id: cord-261151-27ocvgnw author: Becker, Jessica E. title: Pediatric Consultation-Liaison Psychiatry: An Update and Review date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-261151-27ocvgnw.txt cache: ./cache/cord-261151-27ocvgnw.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261151-27ocvgnw.txt' === file2bib.sh === id: cord-262824-xgf5v1ok author: Castillo, Felipe title: On Redeployment to Palliative Care date: 2020-11-10 pages: extension: .txt txt: ./txt/cord-262824-xgf5v1ok.txt cache: ./cache/cord-262824-xgf5v1ok.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262824-xgf5v1ok.txt' === file2bib.sh === id: cord-262412-bs7quwov author: Kaya, Gürkan title: Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-262412-bs7quwov.txt cache: ./cache/cord-262412-bs7quwov.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262412-bs7quwov.txt' === file2bib.sh === id: cord-262729-qcijsyo6 author: Eichberg, Daniel G title: Letter: Academic Neurosurgery Department Response to COVID-19 Pandemic: The University of Miami/Jackson Memorial Hospital Model date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-262729-qcijsyo6.txt cache: ./cache/cord-262729-qcijsyo6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262729-qcijsyo6.txt' === file2bib.sh === id: cord-262796-syu4wbpi author: Wei, Xiao-Shan title: Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19 date: 2020-04-18 pages: extension: .txt txt: ./txt/cord-262796-syu4wbpi.txt cache: ./cache/cord-262796-syu4wbpi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262796-syu4wbpi.txt' === file2bib.sh === id: cord-262708-hctuxrw9 author: Ramachandra, C. title: Outcomes of Cancer Surgery During the COVID-19 Pandemic: Preparedness to Practising Continuous Cancer Care date: 2020-10-19 pages: extension: .txt txt: ./txt/cord-262708-hctuxrw9.txt cache: ./cache/cord-262708-hctuxrw9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262708-hctuxrw9.txt' === file2bib.sh === id: cord-260605-smkr7b15 author: Vestby, Lene K. title: Bacterial Biofilm and its Role in the Pathogenesis of Disease date: 2020-02-03 pages: extension: .txt txt: ./txt/cord-260605-smkr7b15.txt cache: ./cache/cord-260605-smkr7b15.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-260605-smkr7b15.txt' === file2bib.sh === id: cord-262454-bccrvapy author: Szente Fonseca, Silvia Nunes title: Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative Analysis date: 2020-10-31 pages: extension: .txt txt: ./txt/cord-262454-bccrvapy.txt cache: ./cache/cord-262454-bccrvapy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262454-bccrvapy.txt' === file2bib.sh === id: cord-262518-a2ql8hib author: Fan, Peijin Esther Monica title: Needs and concerns of patients in isolation care units - learnings from COVID-19: A reflection date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-262518-a2ql8hib.txt cache: ./cache/cord-262518-a2ql8hib.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262518-a2ql8hib.txt' === file2bib.sh === id: cord-261455-uejtwgar author: Roschewski, Mark title: Inhibition of Bruton tyrosine kinase in patients with severe COVID-19 date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-261455-uejtwgar.txt cache: ./cache/cord-261455-uejtwgar.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261455-uejtwgar.txt' === file2bib.sh === id: cord-262928-l2bqcd0l author: Guarisco, Gloria title: Covid-19 and diabesity: when a pandemia cross another pandemia date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-262928-l2bqcd0l.txt cache: ./cache/cord-262928-l2bqcd0l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262928-l2bqcd0l.txt' === file2bib.sh === id: cord-262780-ilu5oskk author: Sattui, Sebastian E. title: Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19 date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-262780-ilu5oskk.txt cache: ./cache/cord-262780-ilu5oskk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-262780-ilu5oskk.txt' === file2bib.sh === id: cord-263061-ocplcdiv author: Rivetti, Luigi title: Management of Pacemaker Implantation during COVID-19 Infection date: 2020-10-24 pages: extension: .txt txt: ./txt/cord-263061-ocplcdiv.txt cache: ./cache/cord-263061-ocplcdiv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263061-ocplcdiv.txt' === file2bib.sh === id: cord-261941-xf1k5uj1 author: Stackhouse, Robin A. title: Severe acute respiratory syndrome and tuberculosis date: 2005-03-01 pages: extension: .txt txt: ./txt/cord-261941-xf1k5uj1.txt cache: ./cache/cord-261941-xf1k5uj1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-261941-xf1k5uj1.txt' === file2bib.sh === id: cord-262973-mydn7ver author: Zhang, Dekang title: Experts Consensus on Epidemic Prevention and Control in Radiotherapy Centers during the COVID-19 Outbreak: Experiences from Sichuan Province date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-262973-mydn7ver.txt cache: ./cache/cord-262973-mydn7ver.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262973-mydn7ver.txt' === file2bib.sh === id: cord-262998-cugd2t1l author: Singh, Vishwendra title: The novel coronavirus and challenges for general and paediatric dentists date: 2020-05-02 pages: extension: .txt txt: ./txt/cord-262998-cugd2t1l.txt cache: ./cache/cord-262998-cugd2t1l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262998-cugd2t1l.txt' === file2bib.sh === id: cord-263214-h6lkvlj3 author: Bassi, Massimiliano title: BEDSIDE TRANSCERVICAL-TRANSTRACHEAL POST-INTUBATION INJURY REPAIR IN A COVID-19 PATIENT date: 2020-04-22 pages: extension: .txt txt: ./txt/cord-263214-h6lkvlj3.txt cache: ./cache/cord-263214-h6lkvlj3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-263214-h6lkvlj3.txt' === file2bib.sh === id: cord-263055-4f25h9l4 author: Fogarty, Helen title: More on COVID‐19 coagulopathy in Caucasian patients date: 2020-05-25 pages: extension: .txt txt: ./txt/cord-263055-4f25h9l4.txt cache: ./cache/cord-263055-4f25h9l4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-263055-4f25h9l4.txt' === file2bib.sh === id: cord-262987-7h91n9ro author: Bin Traiki, Thamer A. title: Impact of COVID-19 pandemic on patient satisfaction and surgical outcomes: A retrospective and cross sectional study date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-262987-7h91n9ro.txt cache: ./cache/cord-262987-7h91n9ro.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262987-7h91n9ro.txt' === file2bib.sh === id: cord-005727-li8pwigg author: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-005727-li8pwigg.txt cache: ./cache/cord-005727-li8pwigg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-005727-li8pwigg.txt' === file2bib.sh === id: cord-263716-ywsm11aw author: Zhou, Yifan title: Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-263716-ywsm11aw.txt cache: ./cache/cord-263716-ywsm11aw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263716-ywsm11aw.txt' === file2bib.sh === id: cord-262150-j72jbohi author: Cheng, Chun-Hung title: RFID analytics for hospital ward management date: 2015-10-23 pages: extension: .txt txt: ./txt/cord-262150-j72jbohi.txt cache: ./cache/cord-262150-j72jbohi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-262150-j72jbohi.txt' === file2bib.sh === id: cord-262954-saqo900k author: Esme, Mert title: Older Adults With Coronavirus Disease 2019; A Nationwide Study in Turkey date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-262954-saqo900k.txt cache: ./cache/cord-262954-saqo900k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262954-saqo900k.txt' === file2bib.sh === id: cord-263064-n4c0m5hn author: Choudhury, Ivana title: COVID-19 as a Possible Cause of Functional Exhaustion of CD4 and CD8 T-cells and Persistent Cause of Methicillin-Sensitive Staphylococcus aureus Bacteremia date: 2020-07-04 pages: extension: .txt txt: ./txt/cord-263064-n4c0m5hn.txt cache: ./cache/cord-263064-n4c0m5hn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263064-n4c0m5hn.txt' === file2bib.sh === id: cord-263285-89zqgqx1 author: Sethi, Sanjum S. title: Right Ventricular Clot in Transit in COVID-19: Implications for the Pulmonary Embolism Response Team date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-263285-89zqgqx1.txt cache: ./cache/cord-263285-89zqgqx1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263285-89zqgqx1.txt' === file2bib.sh === id: cord-262878-ygvbqmxd author: de Carranza, María title: Aortic thrombus in patients with severe COVID-19: review of three cases date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-262878-ygvbqmxd.txt cache: ./cache/cord-262878-ygvbqmxd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262878-ygvbqmxd.txt' === file2bib.sh === id: cord-263046-3aerbonz author: Hadfield, James N. title: The Evolving COVID-19 Effect on Hip Fracture Patients date: 2020-06-15 pages: extension: .txt txt: ./txt/cord-263046-3aerbonz.txt cache: ./cache/cord-263046-3aerbonz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-263046-3aerbonz.txt' === file2bib.sh === id: cord-262784-r9gq2oan author: Tian, Suochen title: Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-262784-r9gq2oan.txt cache: ./cache/cord-262784-r9gq2oan.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262784-r9gq2oan.txt' === file2bib.sh === id: cord-014687-0am4l5ms author: nan title: SPR 2012 date: 2012-03-29 pages: extension: .txt txt: ./txt/cord-014687-0am4l5ms.txt cache: ./cache/cord-014687-0am4l5ms.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-014687-0am4l5ms.txt' === file2bib.sh === id: cord-263292-qjfe2t9v author: Sansone, A. title: Addressing male sexual and reproductive health in the wake of COVID-19 outbreak date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-263292-qjfe2t9v.txt cache: ./cache/cord-263292-qjfe2t9v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263292-qjfe2t9v.txt' === file2bib.sh === id: cord-262551-hxhlhb5m author: van der Gronde, Toon title: Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-262551-hxhlhb5m.txt cache: ./cache/cord-262551-hxhlhb5m.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-262551-hxhlhb5m.txt' === file2bib.sh === id: cord-263241-qzerj9bs author: Liu, Liu title: Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-263241-qzerj9bs.txt cache: ./cache/cord-263241-qzerj9bs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-263241-qzerj9bs.txt' === file2bib.sh === id: cord-263191-osa3ylkl author: Pericàs, Juan M. title: Hospital at home for the management of COVID-19: preliminary experience with 63 patients date: 2020-09-29 pages: extension: .txt txt: ./txt/cord-263191-osa3ylkl.txt cache: ./cache/cord-263191-osa3ylkl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-263191-osa3ylkl.txt' === file2bib.sh === id: cord-263031-cco2vh0f author: Vultaggio, Alessandra title: Considerations on Biologicals for Patients with allergic disease in times of the COVID‐19 pandemic: an EAACI Statement date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-263031-cco2vh0f.txt cache: ./cache/cord-263031-cco2vh0f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-263031-cco2vh0f.txt' === file2bib.sh === id: cord-264327-uzlavmhx author: Singh, Rajat title: Novel Coronavirus Disease 2019 in a Patient on Durable Left Ventricular Assist Device Support date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-264327-uzlavmhx.txt cache: ./cache/cord-264327-uzlavmhx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-264327-uzlavmhx.txt' === file2bib.sh === id: cord-032181-gmcugd8h author: Song, Jian-Xin title: Main Complications of AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 pages: extension: .txt txt: ./txt/cord-032181-gmcugd8h.txt cache: ./cache/cord-032181-gmcugd8h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-032181-gmcugd8h.txt' === file2bib.sh === id: cord-262467-epqqd8n8 author: Chen, Jun title: COVID-19 infection: the China and Italy perspectives date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-262467-epqqd8n8.txt cache: ./cache/cord-262467-epqqd8n8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262467-epqqd8n8.txt' === file2bib.sh === id: cord-264180-0vd3tr9j author: Gupta, Anupam K title: Is It Safe to Perform Lung Surgery During the Coronavirus Pandemic? date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-264180-0vd3tr9j.txt cache: ./cache/cord-264180-0vd3tr9j.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264180-0vd3tr9j.txt' === file2bib.sh === id: cord-264368-p2fwuh0i author: Gozgec, Elif title: Left Ventricular Thrombus in a Patient Infecting by Covid-19 date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-264368-p2fwuh0i.txt cache: ./cache/cord-264368-p2fwuh0i.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-264368-p2fwuh0i.txt' === file2bib.sh === id: cord-263530-t9ryky6f author: Kamal, Yasmine Mohamed title: Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-263530-t9ryky6f.txt cache: ./cache/cord-263530-t9ryky6f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-263530-t9ryky6f.txt' === file2bib.sh === id: cord-263883-7ba0huwy author: Ansarin, Khalil title: Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial date: 2020-07-19 pages: extension: .txt txt: ./txt/cord-263883-7ba0huwy.txt cache: ./cache/cord-263883-7ba0huwy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-263883-7ba0huwy.txt' === file2bib.sh === id: cord-264073-yhztrscf author: Betonico, Gustavo Navarro title: Challenges in COVID‐19 medical response: a nephrology perspective date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-264073-yhztrscf.txt cache: ./cache/cord-264073-yhztrscf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264073-yhztrscf.txt' === file2bib.sh === id: cord-263882-s5oxr6es author: Najar Nobar, Niloufar title: Patients with specific skin disorders who are affected by COVID‐19: what do experiences say about management strategies? : A systematic review date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-263882-s5oxr6es.txt cache: ./cache/cord-263882-s5oxr6es.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263882-s5oxr6es.txt' === file2bib.sh === id: cord-263793-bmadusm6 author: Velissaris, Dimitrios title: Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-263793-bmadusm6.txt cache: ./cache/cord-263793-bmadusm6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-263793-bmadusm6.txt' === file2bib.sh === id: cord-264122-n64tm6qr author: Gaballa, Salem title: COVID-19 Fears May Be Worse Than the Virus: A Case of Cardiogenic Shock Secondary to Post-Myocardial Infarction Ventricular Septum Rupture date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-264122-n64tm6qr.txt cache: ./cache/cord-264122-n64tm6qr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264122-n64tm6qr.txt' === file2bib.sh === id: cord-014996-p6q0f37c author: nan title: Posters_Monday_12 October 2009 date: 2009-08-06 pages: extension: .txt txt: ./txt/cord-014996-p6q0f37c.txt cache: ./cache/cord-014996-p6q0f37c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-014996-p6q0f37c.txt' === file2bib.sh === id: cord-264751-2l3cqhe2 author: Gawie-Rotman, Moran title: Purpuric rash and fever among hospitalized children aged 0–18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology date: 2019-02-22 pages: extension: .txt txt: ./txt/cord-264751-2l3cqhe2.txt cache: ./cache/cord-264751-2l3cqhe2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264751-2l3cqhe2.txt' === file2bib.sh === id: cord-264449-p3tgjuj4 author: Majumdar, PK title: Orthopaedic Surgery in Times of COVID-19 in India date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-264449-p3tgjuj4.txt cache: ./cache/cord-264449-p3tgjuj4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264449-p3tgjuj4.txt' === file2bib.sh === id: cord-263691-ovsi38bx author: Sadler, Diego title: Practical and cost-effective model to build and sustain a cardio-oncology program date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-263691-ovsi38bx.txt cache: ./cache/cord-263691-ovsi38bx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263691-ovsi38bx.txt' === file2bib.sh === id: cord-264889-1vsvcza2 author: Jackson, Craig T. title: The Ties That Bind: A Coronavirus Disease Journey date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-264889-1vsvcza2.txt cache: ./cache/cord-264889-1vsvcza2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-264889-1vsvcza2.txt' === file2bib.sh === id: cord-264647-9r443j3l author: Talamonti, G. title: Spinal epidural abscess in COVID-19 patients date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-264647-9r443j3l.txt cache: ./cache/cord-264647-9r443j3l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264647-9r443j3l.txt' === file2bib.sh === id: cord-263294-9r84f19u author: Chen, Siyu title: Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-263294-9r84f19u.txt cache: ./cache/cord-263294-9r84f19u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263294-9r84f19u.txt' === file2bib.sh === id: cord-264504-nnvof29x author: Malentacchi, Maria title: Concomitant brain arterial and venous thrombosis in a COVID‐19 patient date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-264504-nnvof29x.txt cache: ./cache/cord-264504-nnvof29x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264504-nnvof29x.txt' === file2bib.sh === id: cord-263908-4ti8l2ea author: Gupta, Ritesh title: Diabetes and COVID-19: evidence, current status and unanswered research questions date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-263908-4ti8l2ea.txt cache: ./cache/cord-263908-4ti8l2ea.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263908-4ti8l2ea.txt' === file2bib.sh === id: cord-264042-4hc2i25r author: Chim, Harvey title: Severe Acute Respiratory Syndrome in a Naval Diver date: 2006-06-17 pages: extension: .txt txt: ./txt/cord-264042-4hc2i25r.txt cache: ./cache/cord-264042-4hc2i25r.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-264042-4hc2i25r.txt' === file2bib.sh === id: cord-263066-umvojci8 author: Smondack, P. title: Kinésithérapie et COVID-19 : de la réanimation à la réhabilitation à domicile. Synthèse des recommandations internationales date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-263066-umvojci8.txt cache: ./cache/cord-263066-umvojci8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-263066-umvojci8.txt' === file2bib.sh === id: cord-263628-ac9gld5l author: Sivapalan, Pradeesh title: Proactive prophylaxis with azithromycin and hydroxychloroquine in hospitalized patients with COVID-19 (ProPAC-COVID): a statistical analysis plan date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-263628-ac9gld5l.txt cache: ./cache/cord-263628-ac9gld5l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263628-ac9gld5l.txt' === file2bib.sh === id: cord-264673-67zopf7s author: Shi, Hongbo title: The inhibition of IL-2/IL-2R gives rise to CD8(+) T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-264673-67zopf7s.txt cache: ./cache/cord-264673-67zopf7s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-264673-67zopf7s.txt' === file2bib.sh === id: cord-264543-b4zwinh2 author: Daher, Valéria Barcelos title: Anosmia: A marker of infection by the new corona virus date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-264543-b4zwinh2.txt cache: ./cache/cord-264543-b4zwinh2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264543-b4zwinh2.txt' === file2bib.sh === id: cord-264972-hrbo3awj author: Yee, Colin title: Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting date: 2016-11-01 pages: extension: .txt txt: ./txt/cord-264972-hrbo3awj.txt cache: ./cache/cord-264972-hrbo3awj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264972-hrbo3awj.txt' === file2bib.sh === id: cord-262766-ndn6iwre author: Easom, Nicholas title: 68 Consecutive patients assessed for COVID-19 infection; experience from a UK regional infectious disease unit date: 2020-03-06 pages: extension: .txt txt: ./txt/cord-262766-ndn6iwre.txt cache: ./cache/cord-262766-ndn6iwre.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-262766-ndn6iwre.txt' === file2bib.sh === id: cord-265799-qda5awuc author: Carothers, Chancey title: Acetylcysteine for the Treatment of Suspected Remdesivir‐Associated Acute Liver Failure in COVID‐19: A Case Series date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-265799-qda5awuc.txt cache: ./cache/cord-265799-qda5awuc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265799-qda5awuc.txt' === file2bib.sh === id: cord-265721-wmz3wywi author: Saini, Kamal S. title: Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-265721-wmz3wywi.txt cache: ./cache/cord-265721-wmz3wywi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265721-wmz3wywi.txt' === file2bib.sh === id: cord-265967-y4639p9m author: Rottenberg, Yakir title: Geriatric patient-centered care during the COVID-19: Provision of interactions vs. the imposition of isolation date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-265967-y4639p9m.txt cache: ./cache/cord-265967-y4639p9m.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-265967-y4639p9m.txt' === file2bib.sh === id: cord-265053-x70501t3 author: Pourhomayoun, Mohammad title: Predicting Mortality Risk in Patients with COVID-19 Using Artificial Intelligence to Help Medical Decision-Making date: 2020-04-01 pages: extension: .txt txt: ./txt/cord-265053-x70501t3.txt cache: ./cache/cord-265053-x70501t3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265053-x70501t3.txt' === file2bib.sh === id: cord-265818-wme1360n author: Cooley, Laura title: Trust and Communication: Responding to Uncertainty date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-265818-wme1360n.txt cache: ./cache/cord-265818-wme1360n.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-265818-wme1360n.txt' === file2bib.sh === id: cord-264779-71s7e18i author: Neumann, Natalie R. title: Medical Toxicology and COVID-19: Our Role in a Pandemic date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-264779-71s7e18i.txt cache: ./cache/cord-264779-71s7e18i.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264779-71s7e18i.txt' === file2bib.sh === id: cord-265082-gjbabh4g author: Xuan, Tian-ming title: Primary percutaneous coronary intervention in a COVID-19 patient with ST-segment elevation myocardial infarction after lung transplantation: a case report date: 2020-05-09 pages: extension: .txt txt: ./txt/cord-265082-gjbabh4g.txt cache: ./cache/cord-265082-gjbabh4g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265082-gjbabh4g.txt' === file2bib.sh === id: cord-264295-7ojvhwb0 author: Maddaloni, Ernesto title: Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II) date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-264295-7ojvhwb0.txt cache: ./cache/cord-264295-7ojvhwb0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-264295-7ojvhwb0.txt' === file2bib.sh === id: cord-264952-0t0t4x0y author: Smith, Sean R title: Proposed Workflow for Rehabilitation in a Field Hospital Setting During the COVID‐19 Pandemic date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-264952-0t0t4x0y.txt cache: ./cache/cord-264952-0t0t4x0y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264952-0t0t4x0y.txt' === file2bib.sh === id: cord-265098-u5qssib9 author: Fu, Xin-yan title: Effect of COVID-19 outbreak on the treatment time of patients with acute ST-segment elevation myocardial infarction date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-265098-u5qssib9.txt cache: ./cache/cord-265098-u5qssib9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265098-u5qssib9.txt' === file2bib.sh === id: cord-264610-kxebc12r author: Chen, Yu title: Clinical characteristics of IgG4-RD patients infected with COVID-19 in Hubei, China date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-264610-kxebc12r.txt cache: ./cache/cord-264610-kxebc12r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264610-kxebc12r.txt' === file2bib.sh === id: cord-266456-10tjzqep author: Sadeghipour, Parham title: Management of ST‐segment‐elevation myocardial infarction during the coronavirus disease 2019 (COVID‐19) outbreak: Iranian“247” National Committee's position paper on primary percutaneous coronary intervention date: 2020-04-22 pages: extension: .txt txt: ./txt/cord-266456-10tjzqep.txt cache: ./cache/cord-266456-10tjzqep.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-266456-10tjzqep.txt' === file2bib.sh === id: cord-264843-cwtdkylo author: Chen, Justin A. title: COVID-19 and telepsychiatry: Early outpatient experiences and implications for the future date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-264843-cwtdkylo.txt cache: ./cache/cord-264843-cwtdkylo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-264843-cwtdkylo.txt' === file2bib.sh === id: cord-014533-6qfecv5h author: Velasquez, T. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 pages: extension: .txt txt: ./txt/cord-014533-6qfecv5h.txt cache: ./cache/cord-014533-6qfecv5h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 15 resourceName b'cord-014533-6qfecv5h.txt' === file2bib.sh === id: cord-263599-cqol8zf2 author: Goodman, Larry title: Infectious diarrhea date: 1999-07-31 pages: extension: .txt txt: ./txt/cord-263599-cqol8zf2.txt cache: ./cache/cord-263599-cqol8zf2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-263599-cqol8zf2.txt' === file2bib.sh === id: cord-265111-d44ireu5 author: D’Ardes, Damiano title: Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-265111-d44ireu5.txt cache: ./cache/cord-265111-d44ireu5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-265111-d44ireu5.txt' === file2bib.sh === id: cord-015368-a0qz4tb9 author: nan title: 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date: 2007 pages: extension: .txt txt: ./txt/cord-015368-a0qz4tb9.txt cache: ./cache/cord-015368-a0qz4tb9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-015368-a0qz4tb9.txt' === file2bib.sh === id: cord-266010-ectnfv5z author: Pediconi, Federica title: Breast imaging and cancer diagnosis during the COVID-19 pandemic: recommendations from the Italian College of Breast Radiologists by SIRM date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-266010-ectnfv5z.txt cache: ./cache/cord-266010-ectnfv5z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-266010-ectnfv5z.txt' === file2bib.sh === id: cord-265812-1hcp36cw author: De Jong, Cornelis N. title: Etanercept for steroid-refractory acute graft-versus-host disease: A single center experience date: 2017-10-26 pages: extension: .txt txt: ./txt/cord-265812-1hcp36cw.txt cache: ./cache/cord-265812-1hcp36cw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-265812-1hcp36cw.txt' === file2bib.sh === id: cord-265052-hfuvm1oh author: Turan, Çağrı title: Change of the diagnostic distribution in applicants to dermatology after COVID ‐19 pandemic: What it whispers to us? date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-265052-hfuvm1oh.txt cache: ./cache/cord-265052-hfuvm1oh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265052-hfuvm1oh.txt' === file2bib.sh === id: cord-264924-ds6jv5ek author: Tambyah, Paul A title: Severe acute respiratory syndrome from the trenches, at a Singapore university hospital date: 2004-11-30 pages: extension: .txt txt: ./txt/cord-264924-ds6jv5ek.txt cache: ./cache/cord-264924-ds6jv5ek.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-264924-ds6jv5ek.txt' === file2bib.sh === id: cord-265934-wjdxqj8h author: Singh, Amrita K. title: A Review of Telemedicine Applications in Otorhinolaryngology: Considerations During the Coronavirus Disease of 2019 Pandemic date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-265934-wjdxqj8h.txt cache: ./cache/cord-265934-wjdxqj8h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265934-wjdxqj8h.txt' === file2bib.sh === id: cord-265230-ozyx8u64 author: Takahari, Daisuke title: Managing a gastrointestinal oncology practice in Japan during the COVID-19 pandemic: single institutional experience in The Cancer Institute Hospital of Japanese Foundation for Cancer Research date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-265230-ozyx8u64.txt cache: ./cache/cord-265230-ozyx8u64.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-265230-ozyx8u64.txt' === file2bib.sh === id: cord-265278-wf5pbvvt author: Fishman, Jay A. title: Case 29-2020: A 66-Year-Old Man with Fever and Shortness of Breath after Liver Transplantation date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-265278-wf5pbvvt.txt cache: ./cache/cord-265278-wf5pbvvt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265278-wf5pbvvt.txt' === file2bib.sh === id: cord-265022-p5cab562 author: Kotfis, Katarzyna title: COVID-19: ICU delirium management during SARS-CoV-2 pandemic date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-265022-p5cab562.txt cache: ./cache/cord-265022-p5cab562.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265022-p5cab562.txt' === file2bib.sh === id: cord-266079-nv28ppft author: Dai, Jinghong title: Corticosteroid treatment in severe COVID-19 pneumonia: two cases and literature review date: 2020-05-25 pages: extension: .txt txt: ./txt/cord-266079-nv28ppft.txt cache: ./cache/cord-266079-nv28ppft.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266079-nv28ppft.txt' === file2bib.sh === id: cord-266450-g9vihgbk author: Tran, Michael title: SARS-CoV-2 and pulmonary embolism: who stole the platelets? date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-266450-g9vihgbk.txt cache: ./cache/cord-266450-g9vihgbk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266450-g9vihgbk.txt' === file2bib.sh === id: cord-266214-l8pmhcd5 author: Wang, Xiaogang title: Management Strategies for Patients After CABG Surgery in the Outbreak of the COVID-19 Pandemic date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-266214-l8pmhcd5.txt cache: ./cache/cord-266214-l8pmhcd5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266214-l8pmhcd5.txt' === file2bib.sh === id: cord-264829-ynel6ore author: Momtazmanesh, Sara title: Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-264829-ynel6ore.txt cache: ./cache/cord-264829-ynel6ore.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264829-ynel6ore.txt' === file2bib.sh === id: cord-005497-w81ysjf9 author: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 pages: extension: .txt txt: ./txt/cord-005497-w81ysjf9.txt cache: ./cache/cord-005497-w81ysjf9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-005497-w81ysjf9.txt' === file2bib.sh === id: cord-266730-mio282vy author: Li, Long‐quan title: COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis date: 2020-03-23 pages: extension: .txt txt: ./txt/cord-266730-mio282vy.txt cache: ./cache/cord-266730-mio282vy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266730-mio282vy.txt' === file2bib.sh === id: cord-266469-n484zqq1 author: King, Michael J. title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system date: 2020-07-04 pages: extension: .txt txt: ./txt/cord-266469-n484zqq1.txt cache: ./cache/cord-266469-n484zqq1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266469-n484zqq1.txt' === file2bib.sh === id: cord-266775-4npowkkz author: Xu, Jun title: Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis date: 2005-10-15 pages: extension: .txt txt: ./txt/cord-266775-4npowkkz.txt cache: ./cache/cord-266775-4npowkkz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-266775-4npowkkz.txt' === file2bib.sh === id: cord-266475-t04pukea author: Balestri, R. title: Late onset of acral necrosis after SARS‐CoV‐2 infection resolution date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-266475-t04pukea.txt cache: ./cache/cord-266475-t04pukea.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-266475-t04pukea.txt' === file2bib.sh === id: cord-266583-avhiqlgy author: Kim, Hae Jin title: Ultra-Low-Dose Chest CT in Patients with Neutropenic Fever and Hematologic Malignancy: Image Quality and Its Diagnostic Performance date: 2014-07-18 pages: extension: .txt txt: ./txt/cord-266583-avhiqlgy.txt cache: ./cache/cord-266583-avhiqlgy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-266583-avhiqlgy.txt' === file2bib.sh === id: cord-266744-31p212aq author: Dick, Lachlan title: Changes in Emergency General Surgery During Covid-19 in Scotland: A Prospective Cohort Study date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-266744-31p212aq.txt cache: ./cache/cord-266744-31p212aq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266744-31p212aq.txt' === file2bib.sh === id: cord-266512-xh6zed03 author: Scala, Enrico title: Atopic statusprotects from severe complications of COVID‐19 date: 2020-08-16 pages: extension: .txt txt: ./txt/cord-266512-xh6zed03.txt cache: ./cache/cord-266512-xh6zed03.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-266512-xh6zed03.txt' === file2bib.sh === id: cord-266463-ci0g1dno author: Lopes, Renato D. title: Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-266463-ci0g1dno.txt cache: ./cache/cord-266463-ci0g1dno.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-266463-ci0g1dno.txt' === file2bib.sh === id: cord-266932-567lbktm author: Escalard, Simon title: Early Brain Imaging Shows Increased Severity of Acute Ischemic Strokes With Large Vessel Occlusion in COVID-19 Patients date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-266932-567lbktm.txt cache: ./cache/cord-266932-567lbktm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-266932-567lbktm.txt' === file2bib.sh === id: cord-267357-7aap2cte author: Elston, Dirk M. title: The coronavirus (COVID-19) epidemic and patient safety date: 2020-02-16 pages: extension: .txt txt: ./txt/cord-267357-7aap2cte.txt cache: ./cache/cord-267357-7aap2cte.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-267357-7aap2cte.txt' === file2bib.sh === id: cord-267020-4mpc246u author: Teixeira, Cassiano title: The medical decision-making process in the time of the coronavirus pandemic date: 2020 pages: extension: .txt txt: ./txt/cord-267020-4mpc246u.txt cache: ./cache/cord-267020-4mpc246u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-267020-4mpc246u.txt' === file2bib.sh === id: cord-267621-oc8bw7ft author: Kevorkian, Jean-Philippe title: Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-267621-oc8bw7ft.txt cache: ./cache/cord-267621-oc8bw7ft.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-267621-oc8bw7ft.txt' === file2bib.sh === id: cord-266160-464v4g8o author: Bajaj, Jasmohan S title: Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-266160-464v4g8o.txt cache: ./cache/cord-266160-464v4g8o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-266160-464v4g8o.txt' === file2bib.sh === id: cord-266750-41gth6o0 author: Puzzitiello, Richard N. title: Inflammatory and Coagulative Considerations for the Management of Orthopaedic Trauma Patients With COVID-19: A Review of the Current Evidence and Our Surgical Experience date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-266750-41gth6o0.txt cache: ./cache/cord-266750-41gth6o0.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-266750-41gth6o0.txt' === file2bib.sh === id: cord-268155-b8lqo52f author: Farrugia, Albert title: Plasma from donors convalescent from SARS-CoV-2 infection – A matter of priorities date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-268155-b8lqo52f.txt cache: ./cache/cord-268155-b8lqo52f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-268155-b8lqo52f.txt' === file2bib.sh === id: cord-266429-0xaz8kbs author: Bader, Feras title: Heart failure and COVID-19 date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-266429-0xaz8kbs.txt cache: ./cache/cord-266429-0xaz8kbs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266429-0xaz8kbs.txt' === file2bib.sh === id: cord-267142-ys7z7j8j author: Cheema, Marvi title: Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19) date: 2020-04-02 pages: extension: .txt txt: ./txt/cord-267142-ys7z7j8j.txt cache: ./cache/cord-267142-ys7z7j8j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-267142-ys7z7j8j.txt' === file2bib.sh === id: cord-267287-qodj254z author: Pintado, Juan F. title: How COVID-19 has affected Emergent Visits to a Latin-American Trauma Department: Experience at a Peruvian National Trauma Referral Center date: 2020-11-03 pages: extension: .txt txt: ./txt/cord-267287-qodj254z.txt cache: ./cache/cord-267287-qodj254z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-267287-qodj254z.txt' === file2bib.sh === id: cord-267525-tg4uwent author: Rezaei, Shawheen J. title: Neuromyelitis optica practice and prescribing changes in the setting of Covid19: A survey of neurologists date: 2020-07-11 pages: extension: .txt txt: ./txt/cord-267525-tg4uwent.txt cache: ./cache/cord-267525-tg4uwent.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-267525-tg4uwent.txt' === file2bib.sh === id: cord-266722-qfn2dc1q author: Wormser, Gary P. title: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date: 1987-06-30 pages: extension: .txt txt: ./txt/cord-266722-qfn2dc1q.txt cache: ./cache/cord-266722-qfn2dc1q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266722-qfn2dc1q.txt' === file2bib.sh === id: cord-266905-j9ljwqv0 author: Ecker, Jeffrey L. title: Laboring Alone?: Brief Thoughts on Ethics and Practical Answers During the COVID-19 Pandemic date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-266905-j9ljwqv0.txt cache: ./cache/cord-266905-j9ljwqv0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-266905-j9ljwqv0.txt' === file2bib.sh === id: cord-267300-zbipv9er author: Alalwan, Adel A title: A Hemodialysis Patient with Severe COVID-19 Pneumonia date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-267300-zbipv9er.txt cache: ./cache/cord-267300-zbipv9er.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-267300-zbipv9er.txt' === file2bib.sh === id: cord-267124-8efdzlc0 author: Wichmann, Dominic title: Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-267124-8efdzlc0.txt cache: ./cache/cord-267124-8efdzlc0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-267124-8efdzlc0.txt' === file2bib.sh === id: cord-267788-ukz2wz4a author: Jaffe, Allan S title: Myocardial injury in severe COVID-19 infection date: 2020-06-07 pages: extension: .txt txt: ./txt/cord-267788-ukz2wz4a.txt cache: ./cache/cord-267788-ukz2wz4a.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-267788-ukz2wz4a.txt' === file2bib.sh === id: cord-265262-r01u4jr6 author: Cannarella, Rossella title: Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-265262-r01u4jr6.txt cache: ./cache/cord-265262-r01u4jr6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265262-r01u4jr6.txt' === file2bib.sh === id: cord-266478-642m488a author: Gino, Bruno title: Automated Inflating Resuscitator (AIR): Design and Development of a 3D-Printed Ventilator Prototype and Corresponding Simulation Scenario Based on the Management of a Critical COVID-19 Patient date: 2020-07-11 pages: extension: .txt txt: ./txt/cord-266478-642m488a.txt cache: ./cache/cord-266478-642m488a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266478-642m488a.txt' === file2bib.sh === id: cord-266455-rbblg4pu author: Poole, Stephen title: Rapid syndromic molecular testing in pneumonia: The current landscape and future potential date: 2019-12-03 pages: extension: .txt txt: ./txt/cord-266455-rbblg4pu.txt cache: ./cache/cord-266455-rbblg4pu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-266455-rbblg4pu.txt' === file2bib.sh === id: cord-267041-i94lyfsh author: Ellner, Jerrold J. title: Management of acute and chronic respiratory tract infections date: 1988-09-16 pages: extension: .txt txt: ./txt/cord-267041-i94lyfsh.txt cache: ./cache/cord-267041-i94lyfsh.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-267041-i94lyfsh.txt' === file2bib.sh === id: cord-268252-6g0vbd08 author: Richards, Wayne title: Being a dentist in the pandemic date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-268252-6g0vbd08.txt cache: ./cache/cord-268252-6g0vbd08.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-268252-6g0vbd08.txt' === file2bib.sh === id: cord-268347-xz6fptol author: Kow, Chia Siang title: Pharmacotherapeutic considerations for systemic rheumatic diseases amid the COVID-19 pandemic: more questions than answers date: 2020-08-16 pages: extension: .txt txt: ./txt/cord-268347-xz6fptol.txt cache: ./cache/cord-268347-xz6fptol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268347-xz6fptol.txt' === file2bib.sh === id: cord-266294-ua22udlc author: Koch, Oliver title: 29 Antiviral drugs date: 2010-12-31 pages: extension: .txt txt: ./txt/cord-266294-ua22udlc.txt cache: ./cache/cord-266294-ua22udlc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-266294-ua22udlc.txt' === file2bib.sh === id: cord-268632-p1rsz8fk author: Tartari, Federico title: Herpes zoster in COVID‐19‐positive patients date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-268632-p1rsz8fk.txt cache: ./cache/cord-268632-p1rsz8fk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-268632-p1rsz8fk.txt' === file2bib.sh === id: cord-268049-7xqln70d author: Montrief, Tim title: COVID-19 respiratory support in the emergency department setting date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-268049-7xqln70d.txt cache: ./cache/cord-268049-7xqln70d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268049-7xqln70d.txt' === file2bib.sh === id: cord-267947-dnv2xl0h author: Gornet, Jean-Marc title: What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19? date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-267947-dnv2xl0h.txt cache: ./cache/cord-267947-dnv2xl0h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-267947-dnv2xl0h.txt' === file2bib.sh === id: cord-268140-s5lailkp author: Atal, Shubham title: IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? date: 2020-06-13 pages: extension: .txt txt: ./txt/cord-268140-s5lailkp.txt cache: ./cache/cord-268140-s5lailkp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268140-s5lailkp.txt' === file2bib.sh === id: cord-268455-btuzihsy author: de Santiago, Javier title: COVID-19: gynecologic cancer surgery at a single center in Madrid date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-268455-btuzihsy.txt cache: ./cache/cord-268455-btuzihsy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-268455-btuzihsy.txt' === file2bib.sh === id: cord-268168-yzvag38x author: Scolnick, Barbara title: Remission from Chronic Anorexia Nervosa With Ketogenic Diet and Ketamine: Case Report date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-268168-yzvag38x.txt cache: ./cache/cord-268168-yzvag38x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268168-yzvag38x.txt' === file2bib.sh === id: cord-268211-egy8rgtl author: Barrasa, Helena title: SARS-Cov-2 in Spanish Intensive Care: Early Experience with 15-day Survival In Vitoria date: 2020-04-09 pages: extension: .txt txt: ./txt/cord-268211-egy8rgtl.txt cache: ./cache/cord-268211-egy8rgtl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268211-egy8rgtl.txt' === file2bib.sh === id: cord-268254-1mg7a17c author: Liu, Li title: High neutralizing antibody titer in intensive care unit patients with COVID-19 date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-268254-1mg7a17c.txt cache: ./cache/cord-268254-1mg7a17c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-268254-1mg7a17c.txt' === file2bib.sh === id: cord-267402-kca05rvz author: South, Kieron title: Preceding infection and risk of stroke: An old concept revived by the COVID-19 pandemic date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-267402-kca05rvz.txt cache: ./cache/cord-267402-kca05rvz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-267402-kca05rvz.txt' === file2bib.sh === id: cord-269051-nl0jfqxt author: Patel, Krish title: Use of the IL‐6R Antagonist Tocilizumab in Hospitalized COVID‐19 Patients date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-269051-nl0jfqxt.txt cache: ./cache/cord-269051-nl0jfqxt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269051-nl0jfqxt.txt' === file2bib.sh === id: cord-265472-b1s4stvz author: Guimarães, Luísa Eça title: Vaccines, adjuvants and autoimmunity date: 2015-10-31 pages: extension: .txt txt: ./txt/cord-265472-b1s4stvz.txt cache: ./cache/cord-265472-b1s4stvz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265472-b1s4stvz.txt' === file2bib.sh === id: cord-269105-yuphgyrn author: Dumantepe, Mert title: Subsegmental Thrombus in COVID-19 Pneumonia: Immunothrombosis or Pulmonary Embolism? Data Analysis of Hospitalised Patients With Coronavirus Disease date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-269105-yuphgyrn.txt cache: ./cache/cord-269105-yuphgyrn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-269105-yuphgyrn.txt' === file2bib.sh === id: cord-268886-mpceglk1 author: Bourne, T. title: ISUOG Consensus Statement on rationalization of gynecological ultrasound services in context of SARS‐CoV‐2 date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-268886-mpceglk1.txt cache: ./cache/cord-268886-mpceglk1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268886-mpceglk1.txt' === file2bib.sh === id: cord-268974-7bqh1yas author: Capitelli-McMahon, Helen title: Characterising non-melanoma skin cancer undergoing surgical management during the COVID-19 pandemic date: 2020-11-02 pages: extension: .txt txt: ./txt/cord-268974-7bqh1yas.txt cache: ./cache/cord-268974-7bqh1yas.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-268974-7bqh1yas.txt' === file2bib.sh === id: cord-268879-ajd7ofc8 author: Hui, David S. title: Contemporary Concise Review 2018: Respiratory infections and tuberculosis date: 2019-03-30 pages: extension: .txt txt: ./txt/cord-268879-ajd7ofc8.txt cache: ./cache/cord-268879-ajd7ofc8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268879-ajd7ofc8.txt' === file2bib.sh === id: cord-269280-1zbxjmxu author: Shao, Connie title: The COVID trolley dilemma date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-269280-1zbxjmxu.txt cache: ./cache/cord-269280-1zbxjmxu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-269280-1zbxjmxu.txt' === file2bib.sh === id: cord-269087-f9hyntvf author: Li, X. title: A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19 date: 2020-04-04 pages: extension: .txt txt: ./txt/cord-269087-f9hyntvf.txt cache: ./cache/cord-269087-f9hyntvf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-269087-f9hyntvf.txt' === file2bib.sh === id: cord-269469-7pmnxi9a author: Bikdeli, Behnood title: Anticoagulation in COVID-19: Randomized trials should set the balance between excitement and evidence date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-269469-7pmnxi9a.txt cache: ./cache/cord-269469-7pmnxi9a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-269469-7pmnxi9a.txt' === file2bib.sh === id: cord-268952-3j43p9j3 author: Ueda Oshima, Masumi title: Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach date: 2020-09-26 pages: extension: .txt txt: ./txt/cord-268952-3j43p9j3.txt cache: ./cache/cord-268952-3j43p9j3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268952-3j43p9j3.txt' === file2bib.sh === id: cord-268531-igjeai8c author: Zerah, Lorène title: Clinical Characteristics and Outcomes of 821 Older Patients With SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards: A Multicenter Retrospective Cohort Study date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-268531-igjeai8c.txt cache: ./cache/cord-268531-igjeai8c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-268531-igjeai8c.txt' === file2bib.sh === id: cord-269345-5tlyy8jp author: Minuz, Pietro title: High rate of pulmonary thromboembolism in patients with SARS-CoV-2 pneumonia date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-269345-5tlyy8jp.txt cache: ./cache/cord-269345-5tlyy8jp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269345-5tlyy8jp.txt' === file2bib.sh === id: cord-270079-vwnzp6zj author: Galanis, Nikiforos title: Coagulopathy in COVID-19 infection: a case of acute upper limb ischemia date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-270079-vwnzp6zj.txt cache: ./cache/cord-270079-vwnzp6zj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-270079-vwnzp6zj.txt' === file2bib.sh === id: cord-268617-1t7yaoct author: Ismaili, Nabil title: COVID-19 and Gynecological Cancers: A Summary of International Recommendations date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-268617-1t7yaoct.txt cache: ./cache/cord-268617-1t7yaoct.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268617-1t7yaoct.txt' === file2bib.sh === id: cord-269205-g6eyvnou author: Nilsen, Marci Lee title: Prevision of multidisciplinary head and neck cancer survivorship care during the 2019 novel coronavirus pandemic date: 2020-05-18 pages: extension: .txt txt: ./txt/cord-269205-g6eyvnou.txt cache: ./cache/cord-269205-g6eyvnou.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269205-g6eyvnou.txt' === file2bib.sh === id: cord-268324-86a0n0dc author: Charitos, Ioannis A title: Special features of SARS-CoV-2 in daily practice date: 2020-09-26 pages: extension: .txt txt: ./txt/cord-268324-86a0n0dc.txt cache: ./cache/cord-268324-86a0n0dc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268324-86a0n0dc.txt' === file2bib.sh === id: cord-269009-0i2bvt77 author: D’Souza, Rohan title: A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID‐19 date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-269009-0i2bvt77.txt cache: ./cache/cord-269009-0i2bvt77.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-269009-0i2bvt77.txt' === file2bib.sh === id: cord-269031-sz8ieltb author: Solé, G title: Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-269031-sz8ieltb.txt cache: ./cache/cord-269031-sz8ieltb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269031-sz8ieltb.txt' === file2bib.sh === id: cord-269190-w74bjtq1 author: Lennox, Angela M. title: Care of the Geriatric Rabbit date: 2010-02-11 pages: extension: .txt txt: ./txt/cord-269190-w74bjtq1.txt cache: ./cache/cord-269190-w74bjtq1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269190-w74bjtq1.txt' === file2bib.sh === id: cord-269591-lu415jcp author: nan title: Recommendations Regarding COVID19 Infection in Rheumatic Patients in Greece date: 2020-03-31 pages: extension: .txt txt: ./txt/cord-269591-lu415jcp.txt cache: ./cache/cord-269591-lu415jcp.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-269591-lu415jcp.txt' === file2bib.sh === id: cord-266255-898h9rl1 author: nan title: Full Issue PDF date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-266255-898h9rl1.txt cache: ./cache/cord-266255-898h9rl1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266255-898h9rl1.txt' === file2bib.sh === id: cord-269554-fzu6dy4e author: Hussein, M. H. title: Asthma in COVID-19: An extra chain fitting around the neck? date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-269554-fzu6dy4e.txt cache: ./cache/cord-269554-fzu6dy4e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269554-fzu6dy4e.txt' === file2bib.sh === id: cord-270019-er70ehk4 author: Yang, Kunyu title: Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-270019-er70ehk4.txt cache: ./cache/cord-270019-er70ehk4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270019-er70ehk4.txt' === file2bib.sh === id: cord-270509-roc93m4f author: Radhakrishnan, Suma title: Guidelines for Surgical Tracheostomy and Tracheostomy Tube Change During the COVID-19 Pandemic: A Review Article date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-270509-roc93m4f.txt cache: ./cache/cord-270509-roc93m4f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270509-roc93m4f.txt' === file2bib.sh === id: cord-269275-b7xxk48t author: Tang, Xiaojia title: Neurological manifestations in COVID-19 and its possible mechanism date: 2020-09-27 pages: extension: .txt txt: ./txt/cord-269275-b7xxk48t.txt cache: ./cache/cord-269275-b7xxk48t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-269275-b7xxk48t.txt' === file2bib.sh === id: cord-268843-zml9lbve author: Cuvelier, Geoffrey D.E. title: Clinical presentation, immunologic features, and hematopoietic stem cell transplant outcomes for IKBKB immune deficiency date: 2018-10-31 pages: extension: .txt txt: ./txt/cord-268843-zml9lbve.txt cache: ./cache/cord-268843-zml9lbve.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-268843-zml9lbve.txt' === file2bib.sh === id: cord-268939-ws74xprt author: Ozoner, Baris title: Neurosurgery Practice During Coronavirus Disease 2019 (COVID-19) Pandemic date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-268939-ws74xprt.txt cache: ./cache/cord-268939-ws74xprt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-268939-ws74xprt.txt' === file2bib.sh === id: cord-269099-q5nyzlhs author: Lee, Jisun title: Exploring the spatial arrangement of patient rooms for minimum nurse travel in hospital nursing units in Korea date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-269099-q5nyzlhs.txt cache: ./cache/cord-269099-q5nyzlhs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-269099-q5nyzlhs.txt' === file2bib.sh === id: cord-269503-ij4u980v author: Amaratunga, Eluwana A title: Bradycardia in Patients With COVID-19: A Calm Before the Storm? date: 2020-06-13 pages: extension: .txt txt: ./txt/cord-269503-ij4u980v.txt cache: ./cache/cord-269503-ij4u980v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-269503-ij4u980v.txt' === file2bib.sh === id: cord-269981-xm0by310 author: Shen, Cheng title: Perioperative preparation in thoracic day surgery: Battle against COVID‐19 date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-269981-xm0by310.txt cache: ./cache/cord-269981-xm0by310.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269981-xm0by310.txt' === file2bib.sh === id: cord-269564-r5mmsnbx author: Hans, Diana title: Rapidly Fatal Infections date: 2008-05-31 pages: extension: .txt txt: ./txt/cord-269564-r5mmsnbx.txt cache: ./cache/cord-269564-r5mmsnbx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269564-r5mmsnbx.txt' === file2bib.sh === id: cord-269289-6uog10j4 author: Mabillard, Holly title: Electrolyte Disturbances in SARS-CoV-2 Infection date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-269289-6uog10j4.txt cache: ./cache/cord-269289-6uog10j4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269289-6uog10j4.txt' === file2bib.sh === id: cord-023592-w96h4rir author: nan title: Abstracts cont. date: 2015-12-28 pages: extension: .txt txt: ./txt/cord-023592-w96h4rir.txt cache: ./cache/cord-023592-w96h4rir.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-023592-w96h4rir.txt' === file2bib.sh === id: cord-269690-6r2bfydw author: De Lorenzo, Rebecca title: Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study date: 2020-10-14 pages: extension: .txt txt: ./txt/cord-269690-6r2bfydw.txt cache: ./cache/cord-269690-6r2bfydw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-269690-6r2bfydw.txt' === file2bib.sh === id: cord-266713-rghowch1 author: Reyes-Bueno, JA title: Case fatality of COVID-19 in patients with neurodegenerative dementia date: 2020-10-07 pages: extension: .txt txt: ./txt/cord-266713-rghowch1.txt cache: ./cache/cord-266713-rghowch1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266713-rghowch1.txt' === file2bib.sh === id: cord-270294-g95skuik author: Johnstone, Jennie title: Viral Infection in Adults Hospitalized With Community-Acquired Pneumonia Prevalence, Pathogens, and Presentation date: 2008-12-31 pages: extension: .txt txt: ./txt/cord-270294-g95skuik.txt cache: ./cache/cord-270294-g95skuik.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-270294-g95skuik.txt' === file2bib.sh === id: cord-270124-tqhkzd2w author: Campos, Fábio Guilherme title: General recommendations to the colorectal surgeon during the COVID-19 pandemic date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-270124-tqhkzd2w.txt cache: ./cache/cord-270124-tqhkzd2w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270124-tqhkzd2w.txt' === file2bib.sh === id: cord-269425-e9iyso7n author: Bhattacharjee, Sukrita title: Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-269425-e9iyso7n.txt cache: ./cache/cord-269425-e9iyso7n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269425-e9iyso7n.txt' === file2bib.sh === id: cord-268561-vq1uhj5i author: da Silva, Severino Jefferson Ribeiro title: Clinical and Laboratory Diagnosis of SARS-CoV-2, the Virus Causing COVID-19 date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-268561-vq1uhj5i.txt cache: ./cache/cord-268561-vq1uhj5i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-268561-vq1uhj5i.txt' === file2bib.sh === id: cord-019490-m1cuuehi author: nan title: Abstracts cont. date: 2015-12-28 pages: extension: .txt txt: ./txt/cord-019490-m1cuuehi.txt cache: ./cache/cord-019490-m1cuuehi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-019490-m1cuuehi.txt' === file2bib.sh === id: cord-270327-v4td3zsa author: Atallah, Bassam title: A Marker of Systemic Inflammation or Direct Cardiac Injury: Should Cardiac Troponin Levels be Monitored in COVID-19 Patients? date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-270327-v4td3zsa.txt cache: ./cache/cord-270327-v4td3zsa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270327-v4td3zsa.txt' === file2bib.sh === id: cord-270153-krhkqcev author: Khosla, Seema title: Implementation of Synchronous Telemedicine into Clinical Practice date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-270153-krhkqcev.txt cache: ./cache/cord-270153-krhkqcev.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270153-krhkqcev.txt' === file2bib.sh === id: cord-270391-703js942 author: Rai, Harpreet K title: Atypical Presentation of Panhypopituitarism date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-270391-703js942.txt cache: ./cache/cord-270391-703js942.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-270391-703js942.txt' === file2bib.sh === id: cord-270210-gfy2ytg5 author: Drent, Marjolein title: Benefit of Wearing an Activity Tracker in Sarcoidosis date: 2020-08-22 pages: extension: .txt txt: ./txt/cord-270210-gfy2ytg5.txt cache: ./cache/cord-270210-gfy2ytg5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270210-gfy2ytg5.txt' === file2bib.sh === id: cord-270388-nozh463l author: Damiani, M. title: Extracorporeal Cytokine Hemadsorption in Severe COVID-19 Respiratory Failure date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-270388-nozh463l.txt cache: ./cache/cord-270388-nozh463l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270388-nozh463l.txt' === file2bib.sh === id: cord-270348-5804ffwx author: Angelino, Andrew F. title: Design and implementation of a regional inpatient psychiatry unit for asymptomatic SARS-CoV-2 positive patients. date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-270348-5804ffwx.txt cache: ./cache/cord-270348-5804ffwx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-270348-5804ffwx.txt' === file2bib.sh === id: cord-270525-nmebqrb1 author: Núñez-Velasco, Santiago title: Response to SARS-CoV-2 Pandemic in a Non-COVID-19 Designated Latin-American Neurosurgery Department date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-270525-nmebqrb1.txt cache: ./cache/cord-270525-nmebqrb1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270525-nmebqrb1.txt' === file2bib.sh === id: cord-270712-v6nnnzhm author: Woodcock, J. A. title: Test, test, test! date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-270712-v6nnnzhm.txt cache: ./cache/cord-270712-v6nnnzhm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270712-v6nnnzhm.txt' === file2bib.sh === id: cord-271358-5666nsb9 author: Roncon, Loris title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-271358-5666nsb9.txt cache: ./cache/cord-271358-5666nsb9.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-271358-5666nsb9.txt' === file2bib.sh === id: cord-270665-z4l3lq39 author: Tian, Qing title: Endoscopic mask innovation and protective measures changes during the COVID‐19 pandemic: experience from a Chinese hepato‐biliary‐pancreatic unit date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-270665-z4l3lq39.txt cache: ./cache/cord-270665-z4l3lq39.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-270665-z4l3lq39.txt' === file2bib.sh === id: cord-269511-bfd1dmt3 author: Salacup, Grace title: Characteristics and Clinical Outcomes of COVID‐19 Patients in an Underserved‐Inner City Population: A Single Tertiary Center Cohort date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-269511-bfd1dmt3.txt cache: ./cache/cord-269511-bfd1dmt3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-269511-bfd1dmt3.txt' === file2bib.sh === id: cord-270933-ecmg8kti author: Ali, Ashaq title: COVID-19: Clinical aspects and therapeutics responses date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-270933-ecmg8kti.txt cache: ./cache/cord-270933-ecmg8kti.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270933-ecmg8kti.txt' === file2bib.sh === id: cord-270776-oulnk1b3 author: Chau, Tai-nin title: Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome date: 2004-08-15 pages: extension: .txt txt: ./txt/cord-270776-oulnk1b3.txt cache: ./cache/cord-270776-oulnk1b3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-270776-oulnk1b3.txt' === file2bib.sh === id: cord-270654-cz2y6ta9 author: Deftereos, Spyridon G. title: The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design date: 2020-04-03 pages: extension: .txt txt: ./txt/cord-270654-cz2y6ta9.txt cache: ./cache/cord-270654-cz2y6ta9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270654-cz2y6ta9.txt' === file2bib.sh === id: cord-270876-kul6bs3w author: Morris, Nathaniel P. title: Virtual Visits and the Future of No-Shows date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-270876-kul6bs3w.txt cache: ./cache/cord-270876-kul6bs3w.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270876-kul6bs3w.txt' === file2bib.sh === id: cord-270740-3su8pc3f author: Sultan, Sherif title: COVID-19 Cytokine Storm and Novel Truth date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-270740-3su8pc3f.txt cache: ./cache/cord-270740-3su8pc3f.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-270740-3su8pc3f.txt' === file2bib.sh === id: cord-271603-zy4l9vtf author: Skali, Hicham title: Guidance and Best Practices for Reestablishment of Non-Emergent Care in Nuclear Cardiology Laboratories During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Information Statement from ASNC, IAEA, and SNMMI date: 2020-10-17 pages: extension: .txt txt: ./txt/cord-271603-zy4l9vtf.txt cache: ./cache/cord-271603-zy4l9vtf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-271603-zy4l9vtf.txt' === file2bib.sh === id: cord-270723-cjfglili author: Fteiha, Bashar title: QTc prolongation among hydroxychloroquine sulfate‐treated COVID‐19 patients: An observational study date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-270723-cjfglili.txt cache: ./cache/cord-270723-cjfglili.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270723-cjfglili.txt' === file2bib.sh === id: cord-268540-wrjzr3ws author: Park, You Jeong title: Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-268540-wrjzr3ws.txt cache: ./cache/cord-268540-wrjzr3ws.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-268540-wrjzr3ws.txt' === file2bib.sh === id: cord-270763-idkylpb6 author: Fontes, Cristina Asvolinsque Pantaleão title: Influenza A virus H1N1 associated pneumonia - acute and late aspects evaluated with high resolution tomography in hospitalized patients date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-270763-idkylpb6.txt cache: ./cache/cord-270763-idkylpb6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-270763-idkylpb6.txt' === file2bib.sh === id: cord-270799-2pmpspuj author: Zayet, Souheil title: Clinical features of COVID-19 and influenza: A comparative study on Nord Franche-Comte cluster date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-270799-2pmpspuj.txt cache: ./cache/cord-270799-2pmpspuj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270799-2pmpspuj.txt' === file2bib.sh === id: cord-271220-sntawlnf author: Tadic, Marijana title: COVID‐19 and diabetes: Is there enough evidence? date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-271220-sntawlnf.txt cache: ./cache/cord-271220-sntawlnf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271220-sntawlnf.txt' === file2bib.sh === id: cord-271180-cnrs0zpg author: Rizvi, Saniya title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-271180-cnrs0zpg.txt cache: ./cache/cord-271180-cnrs0zpg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271180-cnrs0zpg.txt' === file2bib.sh === id: cord-270245-zziwb2jy author: Russell, Beth title: Factors Affecting COVID-19 Outcomes in Cancer Patients: A First Report From Guy's Cancer Center in London date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-270245-zziwb2jy.txt cache: ./cache/cord-270245-zziwb2jy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270245-zziwb2jy.txt' === file2bib.sh === id: cord-271149-qnhlfozo author: Huo, Xiang title: Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014 date: 2016-09-01 pages: extension: .txt txt: ./txt/cord-271149-qnhlfozo.txt cache: ./cache/cord-271149-qnhlfozo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271149-qnhlfozo.txt' === file2bib.sh === id: cord-272553-bcmta2he author: Wang, Zhiqiang title: Clinical characteristics and laboratory results of pregnant women with COVID‐19 in Wuhan, China date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-272553-bcmta2he.txt cache: ./cache/cord-272553-bcmta2he.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-272553-bcmta2he.txt' === file2bib.sh === id: cord-272143-6ej3eibd author: Benavides‐Nieto, Marta title: The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy date: 2018-12-21 pages: extension: .txt txt: ./txt/cord-272143-6ej3eibd.txt cache: ./cache/cord-272143-6ej3eibd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272143-6ej3eibd.txt' === file2bib.sh === id: cord-271871-8grkln6o author: Singer, J. S. title: Low Prevalence (0.13%) of COVID-19 Infection in Asymptomatic Pre-operative/Pre-procedure Patients at a Large Academic Medical Center Informs Approaches to Perioperative Care date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-271871-8grkln6o.txt cache: ./cache/cord-271871-8grkln6o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-271871-8grkln6o.txt' === file2bib.sh === id: cord-269835-mz7i66qp author: Furfaro, Federica title: SFED recommendations for IBD endoscopy during COVID-19 pandemic: Italian and French experience date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-269835-mz7i66qp.txt cache: ./cache/cord-269835-mz7i66qp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-269835-mz7i66qp.txt' === file2bib.sh === id: cord-271262-xglhx928 author: Ghia, Samit title: “ANESTHESIA STAT” TO INTUBATE A COVID-19 PATIENT: IMPLICATIONS FOR THE ANESTHESIOLOGIST date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-271262-xglhx928.txt cache: ./cache/cord-271262-xglhx928.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271262-xglhx928.txt' === file2bib.sh === id: cord-271944-oxtus5vb author: Joseph, Rudman title: Seizure And COVID-19: Association and Review of Potential Mechanism date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-271944-oxtus5vb.txt cache: ./cache/cord-271944-oxtus5vb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271944-oxtus5vb.txt' === file2bib.sh === id: cord-272427-jqs00ilp author: Li, Yu-xuan title: The impact of COVID-19 on gastric cancer surgery: a single-center retrospective study date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-272427-jqs00ilp.txt cache: ./cache/cord-272427-jqs00ilp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272427-jqs00ilp.txt' === file2bib.sh === id: cord-272071-445ivhx0 author: Wunsch, Hannah title: Mechanical Ventilation in COVID-19: Interpreting the Current Epidemiology date: 2020-07-01 pages: extension: .txt txt: ./txt/cord-272071-445ivhx0.txt cache: ./cache/cord-272071-445ivhx0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-272071-445ivhx0.txt' === file2bib.sh === id: cord-270628-jtj30v0r author: Alharthy, Abdulrahman title: Prospective Longitudinal Evaluation of Point‐of‐Care Lung Ultrasound in Critically Ill Patients With Severe COVID‐19 Pneumonia date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-270628-jtj30v0r.txt cache: ./cache/cord-270628-jtj30v0r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270628-jtj30v0r.txt' === file2bib.sh === id: cord-271212-y8denvju author: Xu, Xia title: Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China date: 2020-07-25 pages: extension: .txt txt: ./txt/cord-271212-y8denvju.txt cache: ./cache/cord-271212-y8denvju.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271212-y8denvju.txt' === file2bib.sh === id: cord-271896-1ad18z11 author: Janowitz, Tobias title: Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-271896-1ad18z11.txt cache: ./cache/cord-271896-1ad18z11.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-271896-1ad18z11.txt' === file2bib.sh === id: cord-271660-5sfkhg19 author: Sun, Hsin-Yun title: Impact of introducing fluorescent microscopy on hospital tuberculosis control: A before-after study at a high caseload medical center in Taiwan date: 2020-04-03 pages: extension: .txt txt: ./txt/cord-271660-5sfkhg19.txt cache: ./cache/cord-271660-5sfkhg19.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271660-5sfkhg19.txt' === file2bib.sh === id: cord-272318-8yfg1j0o author: Reddy, Sujan T. title: Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-272318-8yfg1j0o.txt cache: ./cache/cord-272318-8yfg1j0o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-272318-8yfg1j0o.txt' === file2bib.sh === id: cord-271483-33kuvpl7 author: Shojaei, Amirahmad title: COVID-19 and off label use of drugs: an ethical viewpoint date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-271483-33kuvpl7.txt cache: ./cache/cord-271483-33kuvpl7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-271483-33kuvpl7.txt' === file2bib.sh === id: cord-272112-egsha2j7 author: Tartarone, Alfredo title: COVID-19 and cancer care: what do international guidelines say? date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-272112-egsha2j7.txt cache: ./cache/cord-272112-egsha2j7.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272112-egsha2j7.txt' === file2bib.sh === id: cord-272727-a5ngjuyz author: Bertsimas, D. title: From predictions to prescriptions: A data-drivenresponse to COVID-19 date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-272727-a5ngjuyz.txt cache: ./cache/cord-272727-a5ngjuyz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-272727-a5ngjuyz.txt' === file2bib.sh === id: cord-272630-2na1gndu author: Benito, Daniel A. title: Local spikes in COVID-19 cases: Recommendations for maintaining otolaryngology clinic operations date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-272630-2na1gndu.txt cache: ./cache/cord-272630-2na1gndu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272630-2na1gndu.txt' === file2bib.sh === id: cord-273090-fdzkfo1u author: He, Susu title: Relationship between Chest CT manifestations and immune response in COVID-19 patients date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-273090-fdzkfo1u.txt cache: ./cache/cord-273090-fdzkfo1u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273090-fdzkfo1u.txt' === file2bib.sh === id: cord-268326-sbz3uk5h author: Bonam, Srinivasa Reddy title: Lysosomes as a therapeutic target date: 2019-09-02 pages: extension: .txt txt: ./txt/cord-268326-sbz3uk5h.txt cache: ./cache/cord-268326-sbz3uk5h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-268326-sbz3uk5h.txt' === file2bib.sh === id: cord-271887-blwrpf38 author: Sampa, Masuda Begum title: Redesigning Portable Health Clinic Platform as a Remote Healthcare System to Tackle COVID-19 Pandemic Situation in Unreached Communities date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-271887-blwrpf38.txt cache: ./cache/cord-271887-blwrpf38.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271887-blwrpf38.txt' === file2bib.sh === id: cord-272585-346ef6qy author: Lombardi, JM title: Addressing a National Crisis: The Spine Hospital and Department's Response to the COVID-19 Pandemic in New York City date: 2020-05-31 pages: extension: .txt txt: ./txt/cord-272585-346ef6qy.txt cache: ./cache/cord-272585-346ef6qy.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-272585-346ef6qy.txt' === file2bib.sh === id: cord-272154-nrm9ulj5 author: Gupta, Ravi title: Guidelines of the Indian Society for Sleep Research (ISSR) for Practice of Sleep Medicine during COVID-19 date: 2020-07-04 pages: extension: .txt txt: ./txt/cord-272154-nrm9ulj5.txt cache: ./cache/cord-272154-nrm9ulj5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-272154-nrm9ulj5.txt' === file2bib.sh === id: cord-272677-6t9kl3hq author: Wu, w. title: Key Points of Clinical and CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) Imported Pneumonia Based On 21 Cases Analysis date: 2020-03-06 pages: extension: .txt txt: ./txt/cord-272677-6t9kl3hq.txt cache: ./cache/cord-272677-6t9kl3hq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272677-6t9kl3hq.txt' === file2bib.sh === id: cord-265848-afkeuwup author: nan title: Chapter 2 Emergency Management of Poisoning date: 2007-12-31 pages: extension: .txt txt: ./txt/cord-265848-afkeuwup.txt cache: ./cache/cord-265848-afkeuwup.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265848-afkeuwup.txt' === file2bib.sh === id: cord-273869-buavj9mm author: Rosés-Gibert, Pau title: Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain date: 2020-09-08 pages: extension: .txt txt: ./txt/cord-273869-buavj9mm.txt cache: ./cache/cord-273869-buavj9mm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273869-buavj9mm.txt' === file2bib.sh === id: cord-273641-8l57mnjt author: Sadr, Sara title: Isolated severe thrombocytopenia in a patient with COVID-19: A case report date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-273641-8l57mnjt.txt cache: ./cache/cord-273641-8l57mnjt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273641-8l57mnjt.txt' === file2bib.sh === id: cord-272778-aixiioii author: Chen, Qingqing title: Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-272778-aixiioii.txt cache: ./cache/cord-272778-aixiioii.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-272778-aixiioii.txt' === file2bib.sh === id: cord-272975-gzsd4ybt author: Antony, Arun title: Systematic review of EEG findings in 617 patients diagnosed with COVID-19 date: 2020-10-19 pages: extension: .txt txt: ./txt/cord-272975-gzsd4ybt.txt cache: ./cache/cord-272975-gzsd4ybt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-272975-gzsd4ybt.txt' === file2bib.sh === id: cord-272655-qeojdpez author: Remolina, Yuly Andrea title: Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia date: 2015-11-17 pages: extension: .txt txt: ./txt/cord-272655-qeojdpez.txt cache: ./cache/cord-272655-qeojdpez.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-272655-qeojdpez.txt' === file2bib.sh === id: cord-272419-y3ebt4jm author: Monari, Caterina title: A Focus on the Nowadays Potential Antiviral Strategies in Early Phase of Coronavirus Disease 2019 (Covid-19): A Narrative Review date: 2020-08-09 pages: extension: .txt txt: ./txt/cord-272419-y3ebt4jm.txt cache: ./cache/cord-272419-y3ebt4jm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272419-y3ebt4jm.txt' === file2bib.sh === id: cord-272976-pb2bjpop author: Washington, Lacey title: ACR Appropriateness Criteria(®) on Acute Respiratory Illness date: 2009-10-01 pages: extension: .txt txt: ./txt/cord-272976-pb2bjpop.txt cache: ./cache/cord-272976-pb2bjpop.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272976-pb2bjpop.txt' === file2bib.sh === id: cord-273602-cq276tj8 author: Bavishi, Chirag title: Acute myocardial injury in patients hospitalized with COVID-19 infection: A review date: 2020-06-06 pages: extension: .txt txt: ./txt/cord-273602-cq276tj8.txt cache: ./cache/cord-273602-cq276tj8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-273602-cq276tj8.txt' === file2bib.sh === id: cord-005105-twsy61oq author: nan title: SIU 2015 Abstracts date: 2015-09-21 pages: extension: .txt txt: ./txt/cord-005105-twsy61oq.txt cache: ./cache/cord-005105-twsy61oq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-005105-twsy61oq.txt' === file2bib.sh === id: cord-271920-1dzkgt6w author: Carpenter, Christopher R. title: Diagnosing COVID‐19 in the Emergency Department: A Scoping Review of Clinical Exam, Labs, Imaging Accuracy and Biases date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-271920-1dzkgt6w.txt cache: ./cache/cord-271920-1dzkgt6w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271920-1dzkgt6w.txt' === file2bib.sh === id: cord-273875-vpp0l6ij author: Johnson, Miguel title: Creating a ‘safe haven’ for the most vulnerable; Early Reports of Management Strategies for Breast Cancer Patients in the UK during the COVID -19 Pandemic times date: 2020-09-20 pages: extension: .txt txt: ./txt/cord-273875-vpp0l6ij.txt cache: ./cache/cord-273875-vpp0l6ij.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-273875-vpp0l6ij.txt' === file2bib.sh === id: cord-273119-jfy0iviy author: Julka-Anderson, Naman title: How COVID-19 is testing and evolving our communication skills date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-273119-jfy0iviy.txt cache: ./cache/cord-273119-jfy0iviy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-273119-jfy0iviy.txt' === file2bib.sh === id: cord-273283-gb0m6fue author: Altschul, David J. title: A novel severity score to predict inpatient mortality in COVID-19 patients date: 2020-10-07 pages: extension: .txt txt: ./txt/cord-273283-gb0m6fue.txt cache: ./cache/cord-273283-gb0m6fue.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273283-gb0m6fue.txt' === file2bib.sh === id: cord-273426-55vu6b3u author: Iba, Toshiaki title: Coagulopathy of Coronavirus Disease 2019 date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-273426-55vu6b3u.txt cache: ./cache/cord-273426-55vu6b3u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273426-55vu6b3u.txt' === file2bib.sh === id: cord-272135-a09bf50o author: Brouqui, Philippe title: Infection control in the management of highly pathogenic infectious diseases: consensus of the European Network of Infectious Disease date: 2009-04-22 pages: extension: .txt txt: ./txt/cord-272135-a09bf50o.txt cache: ./cache/cord-272135-a09bf50o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-272135-a09bf50o.txt' === file2bib.sh === id: cord-273091-40gda9n9 author: Marrie, Thomas J. title: Empiric treatment of ambulatory community-acquired pneumonia: always include treatment for atypical agents date: 2005-03-01 pages: extension: .txt txt: ./txt/cord-273091-40gda9n9.txt cache: ./cache/cord-273091-40gda9n9.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273091-40gda9n9.txt' === file2bib.sh === id: cord-273929-kpcmy9x8 author: Shah, Jatin P. title: The impact of COVID‐19 on Head and Neck surgery, education, and training date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-273929-kpcmy9x8.txt cache: ./cache/cord-273929-kpcmy9x8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-273929-kpcmy9x8.txt' === file2bib.sh === id: cord-273408-jtpaue0z author: Romeyke, Tobias title: COVID-19 Case Report: An 84-Year-Old Man with Exacerbation of Multiple Comorbidities Due to COVID-19 Managed by a Multidisciplinary Team Using Patient-Reported Outcomes date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-273408-jtpaue0z.txt cache: ./cache/cord-273408-jtpaue0z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-273408-jtpaue0z.txt' === file2bib.sh === id: cord-273945-b1lekw47 author: Bongiovanni, Alberto title: Comment on ‘Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey” by Alice Indini et al. date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-273945-b1lekw47.txt cache: ./cache/cord-273945-b1lekw47.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-273945-b1lekw47.txt' === file2bib.sh === id: cord-273317-2e3vmdx4 author: Shekhar, Rahul title: Neurological Complications Among Native Americans with COVID-19: Our Experience at a Tertiary Care Academic Hospital in the U.S. date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-273317-2e3vmdx4.txt cache: ./cache/cord-273317-2e3vmdx4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273317-2e3vmdx4.txt' === file2bib.sh === id: cord-273695-p5p7kvpp author: Fominskiy, Evgeny V. title: Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-273695-p5p7kvpp.txt cache: ./cache/cord-273695-p5p7kvpp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273695-p5p7kvpp.txt' === file2bib.sh === id: cord-274632-d9z0m2l8 author: Chenna, Avantika title: Coronavirus Disease 2019 (COVID-19) in a Renal Transplant Patient date: 2020-05-09 pages: extension: .txt txt: ./txt/cord-274632-d9z0m2l8.txt cache: ./cache/cord-274632-d9z0m2l8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274632-d9z0m2l8.txt' === file2bib.sh === id: cord-274250-95yzt1gj author: Mortaz, Esmaeil title: Silent hypoxia: higher NO in red blood cells of COVID-19 patients date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-274250-95yzt1gj.txt cache: ./cache/cord-274250-95yzt1gj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274250-95yzt1gj.txt' === file2bib.sh === id: cord-274494-heu6rmbt author: Pablos, Jose L title: Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-274494-heu6rmbt.txt cache: ./cache/cord-274494-heu6rmbt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274494-heu6rmbt.txt' === file2bib.sh === id: cord-273175-bao8xxe2 author: Tran, Viet-Thi title: COVID-19–related perceptions, context and attitudes of adults with chronic conditions: Results from a cross-sectional survey nested in the ComPaRe e-cohort date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-273175-bao8xxe2.txt cache: ./cache/cord-273175-bao8xxe2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273175-bao8xxe2.txt' === file2bib.sh === id: cord-000083-3p81yr4n author: nan title: Poster Exhibition date: 2009-01-31 pages: extension: .txt txt: ./txt/cord-000083-3p81yr4n.txt cache: ./cache/cord-000083-3p81yr4n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-000083-3p81yr4n.txt' === file2bib.sh === id: cord-274199-3stjueja author: Baldi, Enrico title: COVID-19 kills at home: the close relationship between the epidemic and the increase of out-of-hospital cardiac arrests date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-274199-3stjueja.txt cache: ./cache/cord-274199-3stjueja.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274199-3stjueja.txt' === file2bib.sh === id: cord-274245-pgfqkwqg author: Rali, Aniket S title: Cardiopulmonary Ultrasonography for Severe Coronavirus Disease 2019 Patients in Prone Position date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-274245-pgfqkwqg.txt cache: ./cache/cord-274245-pgfqkwqg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274245-pgfqkwqg.txt' === file2bib.sh === id: cord-274556-531jlpwr author: Li, Wenrui title: Impact of COVID-19 on Peripheral Arterial Disease Treatment date: 2020-06-02 pages: extension: .txt txt: ./txt/cord-274556-531jlpwr.txt cache: ./cache/cord-274556-531jlpwr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274556-531jlpwr.txt' === file2bib.sh === id: cord-274331-0i2opmcn author: Wang, Catherine J. title: COVID‐19 infection on IL‐23 inhibition date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-274331-0i2opmcn.txt cache: ./cache/cord-274331-0i2opmcn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274331-0i2opmcn.txt' === file2bib.sh === id: cord-273758-hhd8xnve author: Ciardullo, S. title: Impact of diabetes on COVID-19-related in-hospital mortality: a retrospective study from Northern Italy date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-273758-hhd8xnve.txt cache: ./cache/cord-273758-hhd8xnve.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-273758-hhd8xnve.txt' === file2bib.sh === id: cord-273567-8fp3a9h8 author: Zipprich, Hannah M. title: Knowledge, Attitudes, Practices, and Burden During the COVID-19 Pandemic in People with Parkinson’s Disease in Germany date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-273567-8fp3a9h8.txt cache: ./cache/cord-273567-8fp3a9h8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273567-8fp3a9h8.txt' === file2bib.sh === id: cord-274184-hm516x6p author: Elli, Luca title: Endoscopy during the Covid-19 outbreak: experience and recommendations from a single center in a high-incidence scenario date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-274184-hm516x6p.txt cache: ./cache/cord-274184-hm516x6p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274184-hm516x6p.txt' === file2bib.sh === id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 pages: extension: .txt txt: ./txt/cord-014464-m5n250r2.txt cache: ./cache/cord-014464-m5n250r2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-014464-m5n250r2.txt' === file2bib.sh === id: cord-273913-xem3alih author: Marraha, Farah title: A Review of the Dermatological Manifestations of Coronavirus Disease 2019 (COVID-19) date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-273913-xem3alih.txt cache: ./cache/cord-273913-xem3alih.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-273913-xem3alih.txt' === file2bib.sh === id: cord-274542-fpzk5k79 author: Patti, Giuseppe title: Questions and Answers on Practical Thrombotic Issues in SARS-CoV-2 Infection: A Guidance Document from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology date: 2020-11-03 pages: extension: .txt txt: ./txt/cord-274542-fpzk5k79.txt cache: ./cache/cord-274542-fpzk5k79.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274542-fpzk5k79.txt' === file2bib.sh === id: cord-274282-hvx5m2bx author: Liu, Yang title: Association between ages and clinical characteristics and outcomes of coronavirus disease 2019 date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-274282-hvx5m2bx.txt cache: ./cache/cord-274282-hvx5m2bx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274282-hvx5m2bx.txt' === file2bib.sh === id: cord-274008-p3st70u3 author: Mann, E. R. title: Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-274008-p3st70u3.txt cache: ./cache/cord-274008-p3st70u3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274008-p3st70u3.txt' === file2bib.sh === id: cord-274782-yymo9i6r author: Şahbat, Yavuz title: Management of orthopedic oncology patients during coronavirus pandemic date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-274782-yymo9i6r.txt cache: ./cache/cord-274782-yymo9i6r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274782-yymo9i6r.txt' === file2bib.sh === id: cord-274666-0d8oz51l author: Han, Yi title: Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-274666-0d8oz51l.txt cache: ./cache/cord-274666-0d8oz51l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274666-0d8oz51l.txt' === file2bib.sh === id: cord-274563-jimw6skv author: Fiumara, Agata title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 pages: extension: .txt txt: ./txt/cord-274563-jimw6skv.txt cache: ./cache/cord-274563-jimw6skv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274563-jimw6skv.txt' === file2bib.sh === id: cord-275518-p03sl946 author: Borsa, Stefano title: Call of duty: neuro-oncology outpatient management during the COVID-19 pandemic in Milan, ITALY date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-275518-p03sl946.txt cache: ./cache/cord-275518-p03sl946.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-275518-p03sl946.txt' === file2bib.sh === id: cord-273587-nja58vxw author: Rendeiro, A. F. title: Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-273587-nja58vxw.txt cache: ./cache/cord-273587-nja58vxw.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-273587-nja58vxw.txt' === file2bib.sh === id: cord-273614-qmp2tqtb author: Tahir, Faryal title: Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): A Comprehensive Review date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-273614-qmp2tqtb.txt cache: ./cache/cord-273614-qmp2tqtb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-273614-qmp2tqtb.txt' === file2bib.sh === id: cord-274871-jlquvz51 author: Nori, Priya title: Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-274871-jlquvz51.txt cache: ./cache/cord-274871-jlquvz51.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274871-jlquvz51.txt' === file2bib.sh === id: cord-274481-k1dp1ilv author: Falavigna, Maicon title: Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology date: 2020 pages: extension: .txt txt: ./txt/cord-274481-k1dp1ilv.txt cache: ./cache/cord-274481-k1dp1ilv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274481-k1dp1ilv.txt' === file2bib.sh === id: cord-275214-mqvw0219 author: Burlacu, Alexandru title: Is Thrombophilic Genetic Profile Responsible for an Acute Ischemic Stroke in a COVID-19 Male Patient? date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-275214-mqvw0219.txt cache: ./cache/cord-275214-mqvw0219.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-275214-mqvw0219.txt' === file2bib.sh === id: cord-275260-xuhxqkyj author: Sardu, Celestino title: Hyperglycaemia on admission to hospital and COVID-19 date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-275260-xuhxqkyj.txt cache: ./cache/cord-275260-xuhxqkyj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275260-xuhxqkyj.txt' === file2bib.sh === id: cord-273996-z5vlw6nm author: Di Dalmazi, Guido title: Comparison of the effects of lockdown due to COVID-19 on glucose patterns among children, adolescents, and adults with type 1 diabetes: CGM study date: 2020-10-28 pages: extension: .txt txt: ./txt/cord-273996-z5vlw6nm.txt cache: ./cache/cord-273996-z5vlw6nm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-273996-z5vlw6nm.txt' === file2bib.sh === id: cord-274779-0emfl1e5 author: Andrews, Jinsy A. title: Amyotrophic lateral sclerosis care and research in the United States during the COVID‐19 pandemic: Challenges and opportunities date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-274779-0emfl1e5.txt cache: ./cache/cord-274779-0emfl1e5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-274779-0emfl1e5.txt' === file2bib.sh === id: cord-275349-b35pt3mo author: Lenz, Heinz-Josef title: The Emergence of Baricitinib: A Story of Tortoises Versus Hares date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-275349-b35pt3mo.txt cache: ./cache/cord-275349-b35pt3mo.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275349-b35pt3mo.txt' === file2bib.sh === id: cord-275041-fcdwitxy author: Ayerbe, Luis title: The association of treatment with hydroxychloroquine and hospital mortality in COVID-19 patients date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-275041-fcdwitxy.txt cache: ./cache/cord-275041-fcdwitxy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275041-fcdwitxy.txt' === file2bib.sh === id: cord-274121-3w6kc0c9 author: Ramiro, Sofia title: Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-274121-3w6kc0c9.txt cache: ./cache/cord-274121-3w6kc0c9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274121-3w6kc0c9.txt' === file2bib.sh === id: cord-274934-s8xppipe author: Gebbia, Vittorio title: Patients With Cancer and COVID-19: A WhatsApp Messenger-Based Survey of Patients’ Queries, Needs, Fears, and Actions Taken date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-274934-s8xppipe.txt cache: ./cache/cord-274934-s8xppipe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274934-s8xppipe.txt' === file2bib.sh === id: cord-273045-ele1cz86 author: Johnson, Claire D. title: Response of Practicing Chiropractors during the Early Phase of the COVID-19 Pandemic: A Descriptive Report date: 2020-06-13 pages: extension: .txt txt: ./txt/cord-273045-ele1cz86.txt cache: ./cache/cord-273045-ele1cz86.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-273045-ele1cz86.txt' === file2bib.sh === id: cord-274324-obhrbxu4 author: Tian, Wenjie title: Predictors of mortality in hospitalized COVID‐19 patients: A systematic review and meta‐analysis date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-274324-obhrbxu4.txt cache: ./cache/cord-274324-obhrbxu4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274324-obhrbxu4.txt' === file2bib.sh === id: cord-275110-safr9z37 author: Alexander, Paul Elias title: COVID-19 research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-275110-safr9z37.txt cache: ./cache/cord-275110-safr9z37.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275110-safr9z37.txt' === file2bib.sh === id: cord-274355-6hiutrct author: Satheesan, Manoj Kumar title: A numerical study of ventilation strategies for infection risk mitigation in general inpatient wards date: 2020-02-22 pages: extension: .txt txt: ./txt/cord-274355-6hiutrct.txt cache: ./cache/cord-274355-6hiutrct.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274355-6hiutrct.txt' === file2bib.sh === id: cord-275477-blu6wjhu author: Trimaille, Antonin title: COVID-19 et pathologie thromboembolique veineuse date: 2020-09-29 pages: extension: .txt txt: ./txt/cord-275477-blu6wjhu.txt cache: ./cache/cord-275477-blu6wjhu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275477-blu6wjhu.txt' === file2bib.sh === id: cord-276249-9opsg7p2 author: Roberto, Katrina T. title: Electroencephalographic findings in COVID-19 patients: A systematic review date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-276249-9opsg7p2.txt cache: ./cache/cord-276249-9opsg7p2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276249-9opsg7p2.txt' === file2bib.sh === id: cord-274860-7ec2jcoq author: Salazar, Eric title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-274860-7ec2jcoq.txt cache: ./cache/cord-274860-7ec2jcoq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274860-7ec2jcoq.txt' === file2bib.sh === id: cord-276241-4g6pa7kz author: Yurttaş, Berna title: Characteristics and outcomes of Behçet’s syndrome patients with Coronavirus Disease 2019: a case series of 10 patients date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-276241-4g6pa7kz.txt cache: ./cache/cord-276241-4g6pa7kz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276241-4g6pa7kz.txt' === file2bib.sh === id: cord-275266-e6omvo5x author: Kort, Nanne P title: Resuming hip and knee arthroplasty after COVID-19: ethical implications for well-being, safety and the economy date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-275266-e6omvo5x.txt cache: ./cache/cord-275266-e6omvo5x.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275266-e6omvo5x.txt' === file2bib.sh === id: cord-275185-9br8lwma author: Zeng, Hao title: The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-275185-9br8lwma.txt cache: ./cache/cord-275185-9br8lwma.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275185-9br8lwma.txt' === file2bib.sh === id: cord-276303-lgywz9ea author: Rello, Jordi title: COVID-19, steroids and other immunomodulators: The jigsaw is not complete date: 2020-10-25 pages: extension: .txt txt: ./txt/cord-276303-lgywz9ea.txt cache: ./cache/cord-276303-lgywz9ea.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276303-lgywz9ea.txt' === file2bib.sh === id: cord-274557-2071770h author: Späth, Peter J. title: On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events date: 2015-02-05 pages: extension: .txt txt: ./txt/cord-274557-2071770h.txt cache: ./cache/cord-274557-2071770h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274557-2071770h.txt' === file2bib.sh === id: cord-275272-qdg8sqpy author: Soares-Júnior, José Maria title: Gynecology and women’s health care during the COVID-19 pandemic: Patient safety in surgery and prevention date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-275272-qdg8sqpy.txt cache: ./cache/cord-275272-qdg8sqpy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275272-qdg8sqpy.txt' === file2bib.sh === id: cord-275004-qzg03dvg author: Veras, Flavio Protasio title: SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-275004-qzg03dvg.txt cache: ./cache/cord-275004-qzg03dvg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275004-qzg03dvg.txt' === file2bib.sh === id: cord-024651-578c9ut5 author: nan title: 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-024651-578c9ut5.txt cache: ./cache/cord-024651-578c9ut5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-024651-578c9ut5.txt' === file2bib.sh === id: cord-275913-85u6v3ib author: Bauernschmitt, Robert title: Valve-in-valve transcatheter aortic valve replacement in a young patient with a suspected COVID-19 infection: a surgical dilemma in the era of the COVID-19 pandemic date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-275913-85u6v3ib.txt cache: ./cache/cord-275913-85u6v3ib.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275913-85u6v3ib.txt' === file2bib.sh === id: cord-276090-n8c2jpr6 author: Patel, Hiren N. title: Cerebellar Infarction Requiring Surgical Decompression in patient with COVID 19 Pathological Analysis, Brief Review date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-276090-n8c2jpr6.txt cache: ./cache/cord-276090-n8c2jpr6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276090-n8c2jpr6.txt' === file2bib.sh === id: cord-276288-upv2o8f6 author: Prior, Sarah Jane title: Person-centred data collection methods to embed the authentic voice of people who experience health challenges date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-276288-upv2o8f6.txt cache: ./cache/cord-276288-upv2o8f6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276288-upv2o8f6.txt' === file2bib.sh === id: cord-276438-nynri6my author: Lu, Jiade J. title: Experience of a Radiation Oncology Center Operating During the COVID-19 Outbreak date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-276438-nynri6my.txt cache: ./cache/cord-276438-nynri6my.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276438-nynri6my.txt' === file2bib.sh === id: cord-275154-vwnpred5 author: Bermejo-Martin, Jesus F title: Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza date: 2009-12-11 pages: extension: .txt txt: ./txt/cord-275154-vwnpred5.txt cache: ./cache/cord-275154-vwnpred5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275154-vwnpred5.txt' === file2bib.sh === id: cord-276856-88d3vzbs author: Petersen, Lonnie G. title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-276856-88d3vzbs.txt cache: ./cache/cord-276856-88d3vzbs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276856-88d3vzbs.txt' === file2bib.sh === id: cord-276359-syr9av09 author: Piva, Simone title: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy date: 2020-04-14 pages: extension: .txt txt: ./txt/cord-276359-syr9av09.txt cache: ./cache/cord-276359-syr9av09.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276359-syr9av09.txt' === file2bib.sh === id: cord-275257-upj8mvzn author: Hwang, E. Shelley title: Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change date: 2020-06-14 pages: extension: .txt txt: ./txt/cord-275257-upj8mvzn.txt cache: ./cache/cord-275257-upj8mvzn.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275257-upj8mvzn.txt' === file2bib.sh === id: cord-276234-2nkeq4ud author: Siedlecki, Jakob title: COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-276234-2nkeq4ud.txt cache: ./cache/cord-276234-2nkeq4ud.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276234-2nkeq4ud.txt' === file2bib.sh === id: cord-276524-th6eu11h author: Atallah, Bassam title: Thrombotic events following tocilizumab therapy in critically ill COVID-19 patients: a Façade for prognostic markers date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-276524-th6eu11h.txt cache: ./cache/cord-276524-th6eu11h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-276524-th6eu11h.txt' === file2bib.sh === id: cord-276264-wgzh3f5m author: Navlakha, S. title: Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-276264-wgzh3f5m.txt cache: ./cache/cord-276264-wgzh3f5m.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276264-wgzh3f5m.txt' === file2bib.sh === id: cord-275440-fl4dsu7d author: Turnidge, John title: Responsible Prescribing for Upper Respiratory Tract Infections date: 2012-10-10 pages: extension: .txt txt: ./txt/cord-275440-fl4dsu7d.txt cache: ./cache/cord-275440-fl4dsu7d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275440-fl4dsu7d.txt' === file2bib.sh === id: cord-276495-q22jnkn2 author: Belizário, José Ernesto title: Trained innate immunity, COVID-19 therapeutic dilemma, and fake science date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-276495-q22jnkn2.txt cache: ./cache/cord-276495-q22jnkn2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-276495-q22jnkn2.txt' === file2bib.sh === id: cord-276132-tv5y1eqc author: Ray, Upasana title: COVID-19: The Impact in Oncology Care date: 2020-10-23 pages: extension: .txt txt: ./txt/cord-276132-tv5y1eqc.txt cache: ./cache/cord-276132-tv5y1eqc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276132-tv5y1eqc.txt' === file2bib.sh === id: cord-276327-wyevh4xv author: Sheng, Calvin C title: Canakinumab to reduce deterioration of cardiac and respiratory function in SARS‐CoV‐2 associated myocardial injury with heightened inflammation (canakinumab in Covid‐19 cardiac injury: The three C study) date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-276327-wyevh4xv.txt cache: ./cache/cord-276327-wyevh4xv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276327-wyevh4xv.txt' === file2bib.sh === id: cord-275340-q8d7rvnj author: Sun, JingKang title: Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 date: 2020-06-21 pages: extension: .txt txt: ./txt/cord-275340-q8d7rvnj.txt cache: ./cache/cord-275340-q8d7rvnj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275340-q8d7rvnj.txt' === file2bib.sh === id: cord-276343-sb3vd7fq author: Humar, Atul title: Assessment of Adenovirus Infection in Adult Lung Transplant Recipients Using Molecular Surveillance date: 2006-12-31 pages: extension: .txt txt: ./txt/cord-276343-sb3vd7fq.txt cache: ./cache/cord-276343-sb3vd7fq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276343-sb3vd7fq.txt' === file2bib.sh === id: cord-276592-dsilwfl1 author: Chou, Calvin L title: How COVID-19 Disrupts—and Enhances—My Clinical Work date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-276592-dsilwfl1.txt cache: ./cache/cord-276592-dsilwfl1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276592-dsilwfl1.txt' === file2bib.sh === id: cord-275506-3t5gf66c author: Agbuduwe, Charles title: Hematolological Manifestations of COVID‐19: From Cytopenia to Coagulopathy date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-275506-3t5gf66c.txt cache: ./cache/cord-275506-3t5gf66c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-275506-3t5gf66c.txt' === file2bib.sh === id: cord-277189-fe8ego7f author: Szabados, Bernadett title: Clinical Characteristics and Outcome for Four SARS-CoV-2-infected Cancer Patients Treated with Immune Checkpoint Inhibitors date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-277189-fe8ego7f.txt cache: ./cache/cord-277189-fe8ego7f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277189-fe8ego7f.txt' === file2bib.sh === id: cord-276267-77903fld author: Al‐Ani, Aysha H. title: Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-276267-77903fld.txt cache: ./cache/cord-276267-77903fld.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276267-77903fld.txt' === file2bib.sh === id: cord-275979-cx2h5bsw author: Scutelnic, Adrian title: Vascular Events, Vascular Disease and Vascular Risk Factors—Strongly Intertwined with COVID-19 date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-275979-cx2h5bsw.txt cache: ./cache/cord-275979-cx2h5bsw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275979-cx2h5bsw.txt' === file2bib.sh === id: cord-276635-0ciy732e author: Nijjer, Sukhjinder Singh title: Optimal management of acute coronary syndromes in the era of COVID-19 date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-276635-0ciy732e.txt cache: ./cache/cord-276635-0ciy732e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276635-0ciy732e.txt' === file2bib.sh === id: cord-277096-zvb7n9wo author: Bond, David A. title: Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date: 2018-11-29 pages: extension: .txt txt: ./txt/cord-277096-zvb7n9wo.txt cache: ./cache/cord-277096-zvb7n9wo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277096-zvb7n9wo.txt' === file2bib.sh === id: cord-277201-jzjxsetx author: Mazo, Jahinover title: More than Just Pneumonia: Acute Pulmonary Embolism in Two Middle-Aged Patients with COVID-19 date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-277201-jzjxsetx.txt cache: ./cache/cord-277201-jzjxsetx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277201-jzjxsetx.txt' === file2bib.sh === id: cord-276405-yfvu83r9 author: Brat, Gabriel A. title: International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-276405-yfvu83r9.txt cache: ./cache/cord-276405-yfvu83r9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-276405-yfvu83r9.txt' === file2bib.sh === id: cord-276621-9exp8e7h author: Jacobs, Jeremy M. title: Prolonged Mechanical Ventilation: Symptomatology, Well-Being, and Attitudes to Life date: 2020-09-06 pages: extension: .txt txt: ./txt/cord-276621-9exp8e7h.txt cache: ./cache/cord-276621-9exp8e7h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276621-9exp8e7h.txt' === file2bib.sh === id: cord-276782-3fpmatkb author: Garbey, M. title: A Model of Workflow in the Hospital During a Pandemic to Assist Management date: 2020-05-02 pages: extension: .txt txt: ./txt/cord-276782-3fpmatkb.txt cache: ./cache/cord-276782-3fpmatkb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276782-3fpmatkb.txt' === file2bib.sh === id: cord-275742-7jxt6diq author: Batarseh, Feras A. title: Preventive healthcare policies in the US: solutions for disease management using Big Data Analytics date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-275742-7jxt6diq.txt cache: ./cache/cord-275742-7jxt6diq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275742-7jxt6diq.txt' === file2bib.sh === id: cord-276784-8lmg97zc author: Boziki, Marina Kleopatra title: COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated Demyelination date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-276784-8lmg97zc.txt cache: ./cache/cord-276784-8lmg97zc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276784-8lmg97zc.txt' === file2bib.sh === id: cord-276676-lgt0rzob author: Moka, Eleni title: Best Practice in Cardiac Anesthesia during the COVID-19 Pandemic: Practical Recommendations date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-276676-lgt0rzob.txt cache: ./cache/cord-276676-lgt0rzob.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-276676-lgt0rzob.txt' === file2bib.sh === id: cord-276834-20lcihf4 author: Idilman, Ilkay S. title: Lung and kidney perfusion deficits diagnosed by dual-energy computed tomography in patients with COVID-19-related systemic microangiopathy date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-276834-20lcihf4.txt cache: ./cache/cord-276834-20lcihf4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276834-20lcihf4.txt' === file2bib.sh === id: cord-276641-40r4mitg author: Elkhouly, Enas A title: Should cancer treatment be continued during the COVID-19 pandemic? A single Egyptian institution experience date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-276641-40r4mitg.txt cache: ./cache/cord-276641-40r4mitg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276641-40r4mitg.txt' === file2bib.sh === id: cord-277539-xt2nt11e author: Kochhar, Anuraj Singh title: Dentistry during and after COVID-19 Pandemic: Pediatric Considerations date: 2020 pages: extension: .txt txt: ./txt/cord-277539-xt2nt11e.txt cache: ./cache/cord-277539-xt2nt11e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277539-xt2nt11e.txt' === file2bib.sh === id: cord-277498-hdhq99k2 author: Chua, Melvin L.K. title: Follow-up and management of head and neck cancer patients during the 2019 novel coronavirus (SARS-CoV-2) disease pandemic date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-277498-hdhq99k2.txt cache: ./cache/cord-277498-hdhq99k2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-277498-hdhq99k2.txt' === file2bib.sh === id: cord-277535-u283k70i author: Vaja, Rakesh title: Drugs and the liver date: 2020-09-22 pages: extension: .txt txt: ./txt/cord-277535-u283k70i.txt cache: ./cache/cord-277535-u283k70i.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277535-u283k70i.txt' === file2bib.sh === id: cord-277328-9s8fwg1h author: Zhuang, Yuandi title: Dynamic changes on chest CT of COVID-19 patients with solitary pulmonary lesion in initial CT date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-277328-9s8fwg1h.txt cache: ./cache/cord-277328-9s8fwg1h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-277328-9s8fwg1h.txt' === file2bib.sh === id: cord-277576-3dvt6uj7 author: Demir, Erol title: COVID‐19 in kidney transplant recipients: A multicenter experience in Istanbul date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-277576-3dvt6uj7.txt cache: ./cache/cord-277576-3dvt6uj7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277576-3dvt6uj7.txt' === file2bib.sh === id: cord-277148-xzpuc22p author: Ammirati, Enrico title: UPDATE ON ACUTE MYOCARDITIS date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-277148-xzpuc22p.txt cache: ./cache/cord-277148-xzpuc22p.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277148-xzpuc22p.txt' === file2bib.sh === id: cord-277014-iz8jo44e author: Hu, Weihua title: Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-277014-iz8jo44e.txt cache: ./cache/cord-277014-iz8jo44e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277014-iz8jo44e.txt' === file2bib.sh === id: cord-277323-jqr2hkv2 author: Thampi, Swapna title: Considerations for resuscitation and transfer of paediatric patients with COVID-19 date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-277323-jqr2hkv2.txt cache: ./cache/cord-277323-jqr2hkv2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-277323-jqr2hkv2.txt' === file2bib.sh === id: cord-277146-4a4vz36h author: Aggarwal, Mukul title: Hemostatic Abnormalities in COVID-19: An Update date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-277146-4a4vz36h.txt cache: ./cache/cord-277146-4a4vz36h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-277146-4a4vz36h.txt' === file2bib.sh === id: cord-277260-7se220oz author: Gosain, Rohit title: COVID-19 and Cancer: a Comprehensive Review date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-277260-7se220oz.txt cache: ./cache/cord-277260-7se220oz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277260-7se220oz.txt' === file2bib.sh === id: cord-276927-rxudwp2v author: Barbas, Carmen Sílvia Valente title: Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome date: 2012-08-23 pages: extension: .txt txt: ./txt/cord-276927-rxudwp2v.txt cache: ./cache/cord-276927-rxudwp2v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-276927-rxudwp2v.txt' === file2bib.sh === id: cord-277207-2my86ums author: Zhou, H. title: Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19) date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-277207-2my86ums.txt cache: ./cache/cord-277207-2my86ums.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277207-2my86ums.txt' === file2bib.sh === id: cord-277486-12uah5qi author: Kopp, Kristen title: Interdisciplinary Model for Scheduling Post-discharge Cardiopulmonary Care of Patients Following Severe and Critical SARS-CoV-2 (Coronavirus) Infection date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-277486-12uah5qi.txt cache: ./cache/cord-277486-12uah5qi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277486-12uah5qi.txt' === file2bib.sh === id: cord-278300-6cr9h7no author: Lu, X. title: Classification of COVID-19 in intensive care patients: towards rational and effective clinical triage date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-278300-6cr9h7no.txt cache: ./cache/cord-278300-6cr9h7no.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-278300-6cr9h7no.txt' === file2bib.sh === id: cord-278549-br9rr713 author: Madanelo, M. title: The impact of the COVID‐19 pandemic on the utilization of emergency urological services date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-278549-br9rr713.txt cache: ./cache/cord-278549-br9rr713.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278549-br9rr713.txt' === file2bib.sh === id: cord-278547-y0hvq0qf author: Testori, Alberto title: Extraordinary emergency measures set up by a Breast Unit to prevent COVID‐19: Report of our experience date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-278547-y0hvq0qf.txt cache: ./cache/cord-278547-y0hvq0qf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-278547-y0hvq0qf.txt' === file2bib.sh === id: cord-277399-0w8is9xm author: Esteves, Sandro C. title: SARS‐CoV‐2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-277399-0w8is9xm.txt cache: ./cache/cord-277399-0w8is9xm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277399-0w8is9xm.txt' === file2bib.sh === id: cord-277430-x02u7oh0 author: Zhang, Hongyan title: Outcomes of novel coronavirus disease 2019 (COVID‐19) infection in 107 patients with cancer from Wuhan, China date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-277430-x02u7oh0.txt cache: ./cache/cord-277430-x02u7oh0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277430-x02u7oh0.txt' === file2bib.sh === id: cord-277700-nxm1jr0x author: Chassagnon, Guillaume title: AI-Driven CT-based quantification, staging and short-term outcome prediction of COVID-19 pneumonia date: 2020-04-22 pages: extension: .txt txt: ./txt/cord-277700-nxm1jr0x.txt cache: ./cache/cord-277700-nxm1jr0x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277700-nxm1jr0x.txt' === file2bib.sh === id: cord-277178-nbotxv35 author: Vindrola-Padros, C. title: Remote home monitoring (virtual wards) during the COVID-19 pandemic: a living systematic review date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-277178-nbotxv35.txt cache: ./cache/cord-277178-nbotxv35.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277178-nbotxv35.txt' === file2bib.sh === id: cord-277992-49mantab author: Harikrishnan, S. title: Cardiological society of India position statement on COVID-19 and heart failure date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-277992-49mantab.txt cache: ./cache/cord-277992-49mantab.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277992-49mantab.txt' === file2bib.sh === id: cord-277739-eb4z3u66 author: Hu, Ke title: Efficacy and Safety of Lianhuaqingwen Capsules, a repurposed Chinese Herb, in Patients with Coronavirus disease 2019: A multicenter, prospective, randomized controlled trial date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-277739-eb4z3u66.txt cache: ./cache/cord-277739-eb4z3u66.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-277739-eb4z3u66.txt' === file2bib.sh === id: cord-278937-lkuuftno author: Beydon, N. title: Lung function testing during a pandemic: an international perspective date: 2020-10-11 pages: extension: .txt txt: ./txt/cord-278937-lkuuftno.txt cache: ./cache/cord-278937-lkuuftno.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278937-lkuuftno.txt' === file2bib.sh === id: cord-278477-9a7gmzz3 author: Huh, Kyungmin title: Impact of obesity, fasting plasma glucose level, blood pressure, and renal function on the severity of COVID-19: a matter of sexual dimorphism? date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-278477-9a7gmzz3.txt cache: ./cache/cord-278477-9a7gmzz3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278477-9a7gmzz3.txt' === file2bib.sh === id: cord-277811-j58qvyum author: Mehrani, Hossein title: Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis date: 2011-01-07 pages: extension: .txt txt: ./txt/cord-277811-j58qvyum.txt cache: ./cache/cord-277811-j58qvyum.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277811-j58qvyum.txt' === file2bib.sh === id: cord-278943-f80ucqqp author: Calvillo-Argüelles, Oscar title: Modified Routine Cardiac Imaging Surveillance of Adult Cancer Patients and Survivors during the COVID-19 Pandemic date: 2020-04-16 pages: extension: .txt txt: ./txt/cord-278943-f80ucqqp.txt cache: ./cache/cord-278943-f80ucqqp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-278943-f80ucqqp.txt' === file2bib.sh === id: cord-278106-ev1nx60h author: Cancarevic, Ivan title: Coronavirus Disease 2019 (COVID-19) in Cancer Patients date: 2020-04-26 pages: extension: .txt txt: ./txt/cord-278106-ev1nx60h.txt cache: ./cache/cord-278106-ev1nx60h.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278106-ev1nx60h.txt' === file2bib.sh === id: cord-277210-xaj2623u author: Weinkove, Robert title: Managing haematology and oncology patients during the COVID‐19 pandemic: interim consensus guidance date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-277210-xaj2623u.txt cache: ./cache/cord-277210-xaj2623u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-277210-xaj2623u.txt' === file2bib.sh === id: cord-278536-b4eyegx5 author: Piazza, Gregory title: Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19 date: 2020-11-03 pages: extension: .txt txt: ./txt/cord-278536-b4eyegx5.txt cache: ./cache/cord-278536-b4eyegx5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278536-b4eyegx5.txt' === file2bib.sh === id: cord-278332-fbksw3om author: Schlick, Cary Jo R. title: Adequate Lymphadenectomy as a Quality Measure in Esophageal Cancer: Is there an Association with Treatment Approach? date: 2020-06-09 pages: extension: .txt txt: ./txt/cord-278332-fbksw3om.txt cache: ./cache/cord-278332-fbksw3om.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278332-fbksw3om.txt' === file2bib.sh === id: cord-277803-7p1qu2rf author: Rubino, Francesco title: Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-277803-7p1qu2rf.txt cache: ./cache/cord-277803-7p1qu2rf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-277803-7p1qu2rf.txt' === file2bib.sh === id: cord-278682-s4gfbsqy author: Chan, W-M title: Precautions in ophthalmic practice in a hospital with a major acute SARS outbreak: an experience from Hong Kong date: 2005-04-29 pages: extension: .txt txt: ./txt/cord-278682-s4gfbsqy.txt cache: ./cache/cord-278682-s4gfbsqy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-278682-s4gfbsqy.txt' === file2bib.sh === id: cord-277643-xh8z9v0m author: Khatiwada, Asmita Priyadarshini title: Paradigm shift of drug information centers during the COVID-19 pandemic date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-277643-xh8z9v0m.txt cache: ./cache/cord-277643-xh8z9v0m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-277643-xh8z9v0m.txt' === file2bib.sh === id: cord-279238-d49jvws2 author: Folesani, Gianluca title: Cardiac surgery model during COVID-19 pandemic: now it’s time to ramp up date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-279238-d49jvws2.txt cache: ./cache/cord-279238-d49jvws2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-279238-d49jvws2.txt' === file2bib.sh === id: cord-278672-pxzsntfg author: Milenkovic, Aleksandar title: Extensions and Adaptations of Existing Medical Information System in Order to Reduce Social Contacts During COVID-19 Pandemic date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-278672-pxzsntfg.txt cache: ./cache/cord-278672-pxzsntfg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278672-pxzsntfg.txt' === file2bib.sh === id: cord-278592-67y4f9av author: Kurup, Asok title: Control of a hospital-wide vancomycin-resistant Enterococci outbreak date: 2008-03-24 pages: extension: .txt txt: ./txt/cord-278592-67y4f9av.txt cache: ./cache/cord-278592-67y4f9av.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-278592-67y4f9av.txt' === file2bib.sh === id: cord-279052-8hxdfdls author: Boet, S. title: Protocol for a multicentre randomized controlled trial of normobaric versus hyperbaric oxygen therapy for hypoxemic COVID-19 patients date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-279052-8hxdfdls.txt cache: ./cache/cord-279052-8hxdfdls.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279052-8hxdfdls.txt' === file2bib.sh === id: cord-279456-oouylyx9 author: Henchi, Sonia title: First COVID-19 sub-intensive respiratory unit in Europe: the Italian experience date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-279456-oouylyx9.txt cache: ./cache/cord-279456-oouylyx9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279456-oouylyx9.txt' === file2bib.sh === id: cord-028721-x6f26ahr author: Nistal, Manuel title: Non-neoplastic diseases of the testis date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-028721-x6f26ahr.txt cache: ./cache/cord-028721-x6f26ahr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-028721-x6f26ahr.txt' === file2bib.sh === id: cord-279435-ffgd2ets author: ALBalawi, Hani B title: COVID-19: Precautionary Guidelines for Ophthalmologists date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-279435-ffgd2ets.txt cache: ./cache/cord-279435-ffgd2ets.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279435-ffgd2ets.txt' === file2bib.sh === id: cord-279158-dsnniuo6 author: Luo, Y. title: Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-279158-dsnniuo6.txt cache: ./cache/cord-279158-dsnniuo6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279158-dsnniuo6.txt' === file2bib.sh === id: cord-278364-58d8kfdf author: Mohapatra, S. title: Sterilization and Disinfection date: 2017-03-31 pages: extension: .txt txt: ./txt/cord-278364-58d8kfdf.txt cache: ./cache/cord-278364-58d8kfdf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-278364-58d8kfdf.txt' === file2bib.sh === id: cord-278993-w5aa0elj author: Tonetti, Tommaso title: Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-278993-w5aa0elj.txt cache: ./cache/cord-278993-w5aa0elj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-278993-w5aa0elj.txt' === file2bib.sh === id: cord-278256-dmrtsxik author: Qiu, Haiyan title: Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study date: 2020-03-25 pages: extension: .txt txt: ./txt/cord-278256-dmrtsxik.txt cache: ./cache/cord-278256-dmrtsxik.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-278256-dmrtsxik.txt' === file2bib.sh === id: cord-278319-44bvju3g author: Gonzales, Ralph title: Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background date: 2001-06-30 pages: extension: .txt txt: ./txt/cord-278319-44bvju3g.txt cache: ./cache/cord-278319-44bvju3g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-278319-44bvju3g.txt' === file2bib.sh === id: cord-278325-ykcd7d59 author: Cheung, Carmen Ka Man title: Coronavirus Disease 2019 (COVID-19): A Haematologist's Perspective date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-278325-ykcd7d59.txt cache: ./cache/cord-278325-ykcd7d59.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-278325-ykcd7d59.txt' === file2bib.sh === id: cord-279299-5djtiomq author: CAO, HUI-FANG title: A confirmed severe case of human infection with avian-origin influenza H7N9: A case report date: 2014-12-30 pages: extension: .txt txt: ./txt/cord-279299-5djtiomq.txt cache: ./cache/cord-279299-5djtiomq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279299-5djtiomq.txt' === file2bib.sh === id: cord-279480-nqp1pc9v author: Ring, Laurence E. title: What Obstetricians should know about Obstetric Anesthesia during the COVID-19 pandemic date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-279480-nqp1pc9v.txt cache: ./cache/cord-279480-nqp1pc9v.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-279480-nqp1pc9v.txt' === file2bib.sh === id: cord-000977-ka4261wc author: nan title: ECR 2013 Book of Abstracts - B - Scientific Sessions date: 2013-03-07 pages: extension: .txt txt: ./txt/cord-000977-ka4261wc.txt cache: ./cache/cord-000977-ka4261wc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-000977-ka4261wc.txt' === file2bib.sh === id: cord-279134-s6c7m94h author: Chen, Haiyang title: When cancer encounters COVID-19 in China: what have we suffered, experienced and learned date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-279134-s6c7m94h.txt cache: ./cache/cord-279134-s6c7m94h.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279134-s6c7m94h.txt' === file2bib.sh === id: cord-279550-7u2hksxm author: Wang, Kai title: Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-279550-7u2hksxm.txt cache: ./cache/cord-279550-7u2hksxm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279550-7u2hksxm.txt' === file2bib.sh === id: cord-279111-jaa45kyc author: Ieven, M. title: Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries date: 2018-02-12 pages: extension: .txt txt: ./txt/cord-279111-jaa45kyc.txt cache: ./cache/cord-279111-jaa45kyc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279111-jaa45kyc.txt' === file2bib.sh === id: cord-267132-nb0j6k3h author: Loveday, H.P. title: epic3: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England date: 2013-12-10 pages: extension: .txt txt: ./txt/cord-267132-nb0j6k3h.txt cache: ./cache/cord-267132-nb0j6k3h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-267132-nb0j6k3h.txt' === file2bib.sh === id: cord-279732-cea0nt8z author: Bentley, Suzanne K. title: Guidance and Patient Instructions for Proning and Repositioning of Awake, Non‐Intubated COVID‐19 Patients date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-279732-cea0nt8z.txt cache: ./cache/cord-279732-cea0nt8z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279732-cea0nt8z.txt' === file2bib.sh === id: cord-279790-zzvetjrt author: Zeng, Liujun title: Strategic plan for management in oral and maxillofacial surgery during COVID-19 epidemic date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-279790-zzvetjrt.txt cache: ./cache/cord-279790-zzvetjrt.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-279790-zzvetjrt.txt' === file2bib.sh === id: cord-279570-lgbqpfh5 author: Fragkou, Paraskevi C. title: Clinical characteristics and outcomes of measles outbreak in adults: a multicenter retrospective observational study of 93 hospitalized adults in Greece date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-279570-lgbqpfh5.txt cache: ./cache/cord-279570-lgbqpfh5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279570-lgbqpfh5.txt' === file2bib.sh === id: cord-277818-8w15dz20 author: Jaichenco, Andre L. title: Infectious Disease Considerations for the Operating Room date: 2018-02-09 pages: extension: .txt txt: ./txt/cord-277818-8w15dz20.txt cache: ./cache/cord-277818-8w15dz20.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-277818-8w15dz20.txt' === file2bib.sh === id: cord-279846-g0ro8pbb author: Terrigno, Vittorio R title: Right Atrial Thrombus in a Patient With COVID-19 date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-279846-g0ro8pbb.txt cache: ./cache/cord-279846-g0ro8pbb.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-279846-g0ro8pbb.txt' === file2bib.sh === id: cord-278838-qraq5aho author: Mirouse, Adrien title: Severe varicella-zoster virus pneumonia: a multicenter cohort study date: 2017-06-07 pages: extension: .txt txt: ./txt/cord-278838-qraq5aho.txt cache: ./cache/cord-278838-qraq5aho.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278838-qraq5aho.txt' === file2bib.sh === id: cord-278984-0zof6s4d author: El-Tallawy, Salah N. title: Pain Management During the COVID-19 Pandemic date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-278984-0zof6s4d.txt cache: ./cache/cord-278984-0zof6s4d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278984-0zof6s4d.txt' === file2bib.sh === id: cord-279056-mmcoqtb5 author: Seirafianpour, Farnoosh title: Cutaneous manifestations and considerations in COVID‐19 pandemic: A systematic review date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-279056-mmcoqtb5.txt cache: ./cache/cord-279056-mmcoqtb5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279056-mmcoqtb5.txt' === file2bib.sh === id: cord-279667-ikfduu2k author: Ronnje, Louise title: Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-279667-ikfduu2k.txt cache: ./cache/cord-279667-ikfduu2k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279667-ikfduu2k.txt' === file2bib.sh === id: cord-279197-cesemos0 author: Block, Keith I. title: Integrative Cancer Therapies: Learning From COVID-19 date: 2020-06-21 pages: extension: .txt txt: ./txt/cord-279197-cesemos0.txt cache: ./cache/cord-279197-cesemos0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-279197-cesemos0.txt' === file2bib.sh === id: cord-277889-8u685f45 author: Costela-Ruiz, Víctor J. title: SARS-CoV-2 infection: the role of cytokines in COVID-19 disease date: 2020-06-02 pages: extension: .txt txt: ./txt/cord-277889-8u685f45.txt cache: ./cache/cord-277889-8u685f45.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-277889-8u685f45.txt' === file2bib.sh === id: cord-279357-83hisxro author: de Leon, Jose title: Clozapine is strongly associated with the risk of pneumonia and inflammation date: 2020-04-16 pages: extension: .txt txt: ./txt/cord-279357-83hisxro.txt cache: ./cache/cord-279357-83hisxro.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279357-83hisxro.txt' === file2bib.sh === id: cord-274802-7ioiwsd8 author: Varghese, Praveen Mathews title: Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-274802-7ioiwsd8.txt cache: ./cache/cord-274802-7ioiwsd8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274802-7ioiwsd8.txt' === file2bib.sh === id: cord-280129-a97rvtzl author: Honore, Patrick M. title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-280129-a97rvtzl.txt cache: ./cache/cord-280129-a97rvtzl.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-280129-a97rvtzl.txt' === file2bib.sh === id: cord-279513-m4jdc8ua author: Onesti, Concetta Elisa title: Oncological care organisation during COVID-19 outbreak date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-279513-m4jdc8ua.txt cache: ./cache/cord-279513-m4jdc8ua.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279513-m4jdc8ua.txt' === file2bib.sh === id: cord-279557-hk77e3pp author: Drosten, Christian title: Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection date: 2013-06-17 pages: extension: .txt txt: ./txt/cord-279557-hk77e3pp.txt cache: ./cache/cord-279557-hk77e3pp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279557-hk77e3pp.txt' === file2bib.sh === id: cord-280278-gq1hnnwh author: Chi, Meng title: A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-280278-gq1hnnwh.txt cache: ./cache/cord-280278-gq1hnnwh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-280278-gq1hnnwh.txt' === file2bib.sh === id: cord-279571-chiadufa author: Cui, Xiaoyang title: Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-279571-chiadufa.txt cache: ./cache/cord-279571-chiadufa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-279571-chiadufa.txt' === file2bib.sh === id: cord-280507-1nf2ycp3 author: Álvarez‐Román, MT title: Clinical trials and Haemophilia during the COVID‐19’ pandemic: Madrid’s Experience date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-280507-1nf2ycp3.txt cache: ./cache/cord-280507-1nf2ycp3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-280507-1nf2ycp3.txt' === file2bib.sh === id: cord-279736-udsbcqfs author: Abdalkader, Mohamad title: Roadmap for Resuming Elective Neuroendovascular Procedures Following the First COVID-19 Surge date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-279736-udsbcqfs.txt cache: ./cache/cord-279736-udsbcqfs.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-279736-udsbcqfs.txt' === file2bib.sh === id: cord-279719-z0wuajpx author: Martin-Fumadó, Carles title: Medico-legal and ethical considerations on resource limitation and clinical decisions during the COVID-19 pandemic date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-279719-z0wuajpx.txt cache: ./cache/cord-279719-z0wuajpx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279719-z0wuajpx.txt' === file2bib.sh === id: cord-279396-qmixem8i author: Carter, Chris title: COVID-19 Disease: a critical care perspective date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-279396-qmixem8i.txt cache: ./cache/cord-279396-qmixem8i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279396-qmixem8i.txt' === file2bib.sh === id: cord-280097-f7ky61ds author: Zarogoulidis, Paul title: Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? date: 2011-01-07 pages: extension: .txt txt: ./txt/cord-280097-f7ky61ds.txt cache: ./cache/cord-280097-f7ky61ds.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-280097-f7ky61ds.txt' === file2bib.sh === id: cord-280005-i9fp5rys author: Wang, Mengmei title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -- a Single-Center, Randomized, Controlled Clinical Trial date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-280005-i9fp5rys.txt cache: ./cache/cord-280005-i9fp5rys.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280005-i9fp5rys.txt' === file2bib.sh === id: cord-279483-gwikyux2 author: Wong, Joshua Guoxian title: Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department date: 2020-11-02 pages: extension: .txt txt: ./txt/cord-279483-gwikyux2.txt cache: ./cache/cord-279483-gwikyux2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-279483-gwikyux2.txt' === file2bib.sh === id: cord-280070-c1bkhgaz author: Azadeh, Natalya title: The Role of Infection in Interstitial Lung Diseases A Review date: 2017-10-31 pages: extension: .txt txt: ./txt/cord-280070-c1bkhgaz.txt cache: ./cache/cord-280070-c1bkhgaz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280070-c1bkhgaz.txt' === file2bib.sh === id: cord-280280-9jr7ekbu author: Bertoncelli, Deborah title: COVID19: potential cardiovascular issues in pediatric patients date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-280280-9jr7ekbu.txt cache: ./cache/cord-280280-9jr7ekbu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280280-9jr7ekbu.txt' === file2bib.sh === id: cord-280984-2j8ckz14 author: Roux, CH title: Impact of home confinement during the COVID‐19 pandemic on medication use and disease activity in spondyloarthritis patients date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-280984-2j8ckz14.txt cache: ./cache/cord-280984-2j8ckz14.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-280984-2j8ckz14.txt' === file2bib.sh === id: cord-281130-9tawihti author: Schirinzi, Annalisa title: Pentraxin 3: Potential prognostic role in SARS-CoV-2 patients admitted to the emergency department date: 2020-11-02 pages: extension: .txt txt: ./txt/cord-281130-9tawihti.txt cache: ./cache/cord-281130-9tawihti.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281130-9tawihti.txt' === file2bib.sh === id: cord-280233-avmisu31 author: Chase, J. Geoffrey title: Safe doubling of ventilator capacity: a last resort proposal for last resorts date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-280233-avmisu31.txt cache: ./cache/cord-280233-avmisu31.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280233-avmisu31.txt' === file2bib.sh === id: cord-280944-uphs5gvl author: Stagnell, S. title: COVID and consent date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-280944-uphs5gvl.txt cache: ./cache/cord-280944-uphs5gvl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-280944-uphs5gvl.txt' === file2bib.sh === id: cord-280794-k591vqji author: Bauer, Melissa E. title: Neuraxial Procedures in COVID-19–Positive Parturients: A Review of Current Reports date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-280794-k591vqji.txt cache: ./cache/cord-280794-k591vqji.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-280794-k591vqji.txt' === file2bib.sh === id: cord-280848-z0sbztkw author: Setzen, Michael title: COVID-19 and rhinology: A look at the future date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-280848-z0sbztkw.txt cache: ./cache/cord-280848-z0sbztkw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280848-z0sbztkw.txt' === file2bib.sh === id: cord-280431-tuzdng4h author: Alinier, Guillaume title: 5 Basing a Nonclinician's Career upon Simulation The Personal Experience of a Physicist date: 2008-12-31 pages: extension: .txt txt: ./txt/cord-280431-tuzdng4h.txt cache: ./cache/cord-280431-tuzdng4h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-280431-tuzdng4h.txt' === file2bib.sh === id: cord-280628-ok62havd author: Groß, Sonja title: SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-280628-ok62havd.txt cache: ./cache/cord-280628-ok62havd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280628-ok62havd.txt' === file2bib.sh === id: cord-281060-1ud5hzlh author: Méndez Maestro, Irune title: Skin manifestations in patients hospitalized with confirmed COVID‐19 disease: a cross‐sectional study in a tertiary hospital date: 2020-09-24 pages: extension: .txt txt: ./txt/cord-281060-1ud5hzlh.txt cache: ./cache/cord-281060-1ud5hzlh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-281060-1ud5hzlh.txt' === file2bib.sh === id: cord-281003-7pdhxdzc author: Farmakis, Dimitrios title: COVID‐19 and thalassaemia: A position statement of the Thalassaemia International Federation date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-281003-7pdhxdzc.txt cache: ./cache/cord-281003-7pdhxdzc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-281003-7pdhxdzc.txt' === file2bib.sh === id: cord-280060-gzby85u9 author: Rello, Jordi title: Management of infections in critically ill returning travellers in the intensive care unit—II: clinical syndromes and special considerations in immunocompromised patients() date: 2016-04-28 pages: extension: .txt txt: ./txt/cord-280060-gzby85u9.txt cache: ./cache/cord-280060-gzby85u9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-280060-gzby85u9.txt' === file2bib.sh === id: cord-280961-fka8c69p author: Zhang, Rui title: CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-280961-fka8c69p.txt cache: ./cache/cord-280961-fka8c69p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280961-fka8c69p.txt' === file2bib.sh === id: cord-282483-0zsvhoog author: Ghisa, Matteo title: Reorganization of the Functional Gastrointestinal Disorders Unit during the SARS-CoV-2 Outbreak - Practical Recommendations date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-282483-0zsvhoog.txt cache: ./cache/cord-282483-0zsvhoog.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282483-0zsvhoog.txt' === file2bib.sh === id: cord-281283-h6yai7sx author: Ma, Jun title: Emergency response strategy for containing COVID-19 within a psychiatric specialty hospital in the epicenter of the COVID-19 epidemic in China date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-281283-h6yai7sx.txt cache: ./cache/cord-281283-h6yai7sx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-281283-h6yai7sx.txt' === file2bib.sh === id: cord-281752-64mrflcr author: Vespignani, Hervé title: Report of EEG Finding on Critically Ill Patients with COVID‐19 date: 2020-06-13 pages: extension: .txt txt: ./txt/cord-281752-64mrflcr.txt cache: ./cache/cord-281752-64mrflcr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-281752-64mrflcr.txt' === file2bib.sh === id: cord-280348-vrnxucye author: Argano, Christiano title: Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-280348-vrnxucye.txt cache: ./cache/cord-280348-vrnxucye.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280348-vrnxucye.txt' === file2bib.sh === id: cord-280241-h16s6wwm author: McStay, R. title: COVID-19: looking beyond the peak. Challenges and tips for radiologists in follow-up of a novel patient cohort date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-280241-h16s6wwm.txt cache: ./cache/cord-280241-h16s6wwm.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-280241-h16s6wwm.txt' === file2bib.sh === id: cord-281064-b69p44uq author: Ozder, Aclan title: A Novel Indicator Predicts 2019 Novel Coronavirus Infection in Subjects with Diabetes date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-281064-b69p44uq.txt cache: ./cache/cord-281064-b69p44uq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-281064-b69p44uq.txt' === file2bib.sh === id: cord-280111-6hiuzkvz author: Maspero, Cinzia title: Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-280111-6hiuzkvz.txt cache: ./cache/cord-280111-6hiuzkvz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-280111-6hiuzkvz.txt' === file2bib.sh === id: cord-280551-9hoxy5ok author: Kim, Donghee title: Predictors of Outcomes of COVID-19 in Patients with Chronic Liver Disease: US Multi-center Study date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-280551-9hoxy5ok.txt cache: ./cache/cord-280551-9hoxy5ok.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280551-9hoxy5ok.txt' === file2bib.sh === id: cord-282183-k0pn0ie2 author: Spiezia, Luca title: More severe hypercoagulable state in acute COVID-19 pneumonia as compared to other pneumonia. date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-282183-k0pn0ie2.txt cache: ./cache/cord-282183-k0pn0ie2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282183-k0pn0ie2.txt' === file2bib.sh === id: cord-281106-vzb5xzza author: Zerwes, S. title: COVID-19-Infektion – Risiko für thrombembolische Komplikationen date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-281106-vzb5xzza.txt cache: ./cache/cord-281106-vzb5xzza.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-281106-vzb5xzza.txt' === file2bib.sh === id: cord-281276-rffp6qe2 author: Rhazi, Karima El title: Ethical issues related to the hydroxychloroquine treatment prescription for Covid-19 date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-281276-rffp6qe2.txt cache: ./cache/cord-281276-rffp6qe2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-281276-rffp6qe2.txt' === file2bib.sh === id: cord-281298-qheq9lc8 author: Merks, Piotr title: The legal extension of the role of pharmacists in light of the COVID-19 global pandemic date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-281298-qheq9lc8.txt cache: ./cache/cord-281298-qheq9lc8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281298-qheq9lc8.txt' === file2bib.sh === id: cord-281175-og3myz22 author: Tapper, Elliot B. title: The COVID-19 pandemic will have a long-lasting impact on the quality of cirrhosis care date: 2020-04-13 pages: extension: .txt txt: ./txt/cord-281175-og3myz22.txt cache: ./cache/cord-281175-og3myz22.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-281175-og3myz22.txt' === file2bib.sh === id: cord-280030-neqycg6v author: Sewlall, Nivesh H. title: Clinical Features and Patient Management of Lujo Hemorrhagic Fever date: 2014-11-13 pages: extension: .txt txt: ./txt/cord-280030-neqycg6v.txt cache: ./cache/cord-280030-neqycg6v.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-280030-neqycg6v.txt' === file2bib.sh === id: cord-281346-bjhdy8mg author: Palacios Cruz, M. title: COVID-19, a worldwide public health emergency() date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-281346-bjhdy8mg.txt cache: ./cache/cord-281346-bjhdy8mg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281346-bjhdy8mg.txt' === file2bib.sh === id: cord-281945-jvnjzjds author: Radnis, Caitlin title: Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia date: 2020-09-06 pages: extension: .txt txt: ./txt/cord-281945-jvnjzjds.txt cache: ./cache/cord-281945-jvnjzjds.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-281945-jvnjzjds.txt' === file2bib.sh === id: cord-281039-a7q5nzwn author: Rodilla, Enrique title: Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-281039-a7q5nzwn.txt cache: ./cache/cord-281039-a7q5nzwn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-281039-a7q5nzwn.txt' === file2bib.sh === id: cord-280821-kc0ut4oy author: Venturini, Elisabetta title: Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date: 2020-09-24 pages: extension: .txt txt: ./txt/cord-280821-kc0ut4oy.txt cache: ./cache/cord-280821-kc0ut4oy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-280821-kc0ut4oy.txt' === file2bib.sh === id: cord-281332-5mddyv0n author: Wilson, Michael R. title: A novel cause of chronic viral meningoencephalitis: Cache Valley virus date: 2017-07-25 pages: extension: .txt txt: ./txt/cord-281332-5mddyv0n.txt cache: ./cache/cord-281332-5mddyv0n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281332-5mddyv0n.txt' === file2bib.sh === id: cord-280358-ru2hv6pz author: Auvinen, R. title: Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients: a prospective observational study date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-280358-ru2hv6pz.txt cache: ./cache/cord-280358-ru2hv6pz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-280358-ru2hv6pz.txt' === file2bib.sh === id: cord-281344-iswbgqqe author: Jonker, Leonie T. title: Perioperative telemonitoring of older adults with cancer: Can we connect them all? date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-281344-iswbgqqe.txt cache: ./cache/cord-281344-iswbgqqe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-281344-iswbgqqe.txt' === file2bib.sh === id: cord-282219-7kzbnymp author: Wu, Liu title: The effect of massage on the quality of life in patients recovering from COVID-19: A systematic review protocol date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-282219-7kzbnymp.txt cache: ./cache/cord-282219-7kzbnymp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282219-7kzbnymp.txt' === file2bib.sh === id: cord-282043-cs1oyohu author: Giustino, Gennaro title: Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC Focus Seminar date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-282043-cs1oyohu.txt cache: ./cache/cord-282043-cs1oyohu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282043-cs1oyohu.txt' === file2bib.sh === id: cord-280554-9jp85yzz author: Lamure, Sylvain title: Determinants of outcome in Covid-19 hospitalized patients with lymphoma: A retrospective multicentric cohort study date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-280554-9jp85yzz.txt cache: ./cache/cord-280554-9jp85yzz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280554-9jp85yzz.txt' === file2bib.sh === id: cord-281391-0qkku2jd author: Miller-Handley, Hilary title: Treatment Options for COVID-19 in Patients with Reduced or Absent Kidney Function date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-281391-0qkku2jd.txt cache: ./cache/cord-281391-0qkku2jd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281391-0qkku2jd.txt' === file2bib.sh === id: cord-280360-rh37d5wc author: Gibson, David S. title: Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease date: 2009-05-02 pages: extension: .txt txt: ./txt/cord-280360-rh37d5wc.txt cache: ./cache/cord-280360-rh37d5wc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280360-rh37d5wc.txt' === file2bib.sh === id: cord-281733-bsq0ewac author: Veyseh, Maedeh title: Left gonadal vein thrombosis in a patient with COVID-19-associated coagulopathy date: 2020-09-07 pages: extension: .txt txt: ./txt/cord-281733-bsq0ewac.txt cache: ./cache/cord-281733-bsq0ewac.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-281733-bsq0ewac.txt' === file2bib.sh === id: cord-282535-gnuhjs32 author: Cook, Gordon title: Real‐world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID‐19 disease) in patients with Multiple Myeloma receiving systemic anti‐cancer therapy. date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-282535-gnuhjs32.txt cache: ./cache/cord-282535-gnuhjs32.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282535-gnuhjs32.txt' === file2bib.sh === id: cord-281729-z321pebe author: Santos, Cláudia title: Pathophysiology of acute fibrinous and organizing pneumonia – Clinical and morphological spectra date: 2019-05-02 pages: extension: .txt txt: ./txt/cord-281729-z321pebe.txt cache: ./cache/cord-281729-z321pebe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281729-z321pebe.txt' === file2bib.sh === id: cord-282097-a1pwq4fi author: Hoertel, N. title: Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-282097-a1pwq4fi.txt cache: ./cache/cord-282097-a1pwq4fi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282097-a1pwq4fi.txt' === file2bib.sh === id: cord-280996-anq680a1 author: Agarwal, Arnav title: High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission date: 2020-06-15 pages: extension: .txt txt: ./txt/cord-280996-anq680a1.txt cache: ./cache/cord-280996-anq680a1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280996-anq680a1.txt' === file2bib.sh === id: cord-281887-b511bjdy author: Ribeiro, Reitan title: Perioperative Cancer Care in the Context of Limited Resources during the COVID-19 Pandemic: Brazilian Society of Surgical Oncology Recommendations date: 2020-09-26 pages: extension: .txt txt: ./txt/cord-281887-b511bjdy.txt cache: ./cache/cord-281887-b511bjdy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-281887-b511bjdy.txt' === file2bib.sh === id: cord-282660-9x937eus author: Muñoz Vives, Josep Maria title: Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-282660-9x937eus.txt cache: ./cache/cord-282660-9x937eus.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-282660-9x937eus.txt' === file2bib.sh === id: cord-282021-m1lh7mzd author: El Shamy, Osama title: Telenephrology with Remote Peritoneal Dialysis Monitoring during Coronavirus Disease 19 date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-282021-m1lh7mzd.txt cache: ./cache/cord-282021-m1lh7mzd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282021-m1lh7mzd.txt' === file2bib.sh === id: cord-282361-gje78nb1 author: Gökce, Mehmet İlker title: How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE–IAU multicenter collaborative cohort study date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-282361-gje78nb1.txt cache: ./cache/cord-282361-gje78nb1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-282361-gje78nb1.txt' === file2bib.sh === id: cord-281804-lhnw8jx5 author: Sonis, Jonathan D. title: Humanism in the Age of COVID-19: Renewing Focus on Communication and Compassion date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-281804-lhnw8jx5.txt cache: ./cache/cord-281804-lhnw8jx5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281804-lhnw8jx5.txt' === file2bib.sh === id: cord-282589-xof56j98 author: Lopes, M. I. F. title: Beneficial effects of colchicine for moderate to severe COVID-19: an interim analysis of a randomized, double-blinded, placebo controlled clinical trial date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-282589-xof56j98.txt cache: ./cache/cord-282589-xof56j98.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282589-xof56j98.txt' === file2bib.sh === id: cord-281561-r10y2sgb author: Tiwari, Nidhi title: Novel β-Coronavirus (SARS-CoV-2): Current and Future Aspects of Pharmacological Treatments date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-281561-r10y2sgb.txt cache: ./cache/cord-281561-r10y2sgb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281561-r10y2sgb.txt' === file2bib.sh === id: cord-282430-u5ukqc5z author: Fenton, Mark E. title: An Expanded COVID-19 Telemedicine Intermediate Care Model Using Repurposed Hotel Rooms date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-282430-u5ukqc5z.txt cache: ./cache/cord-282430-u5ukqc5z.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282430-u5ukqc5z.txt' === file2bib.sh === id: cord-282704-qg2o0ug4 author: Li, Xun title: Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China date: 2020-02-25 pages: extension: .txt txt: ./txt/cord-282704-qg2o0ug4.txt cache: ./cache/cord-282704-qg2o0ug4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282704-qg2o0ug4.txt' === file2bib.sh === id: cord-282963-p04c5nn7 author: Oliveros, Estefania title: Rapid Deterioration of Hospital-Acquired COVID-19 in a Patient on Extracorporeal Left Ventricular Assist Support date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-282963-p04c5nn7.txt cache: ./cache/cord-282963-p04c5nn7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282963-p04c5nn7.txt' === file2bib.sh === id: cord-282474-74273qgk author: Roehrig, Stefan title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-11 pages: extension: .txt txt: ./txt/cord-282474-74273qgk.txt cache: ./cache/cord-282474-74273qgk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282474-74273qgk.txt' === file2bib.sh === id: cord-282730-pawasfh4 author: Contreras, Carlo M. title: Telemedicine: Patient-Provider Clinical Engagement During the COVID-19 Pandemic and Beyond date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-282730-pawasfh4.txt cache: ./cache/cord-282730-pawasfh4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282730-pawasfh4.txt' === file2bib.sh === id: cord-282912-jegpgqqi author: Pilato, Emanuele title: Mechanical complications of Myocardial Infarction during Covid-19 Pandemic: An Italian single-Centre experience: Heart ruptures in covid-19 era date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-282912-jegpgqqi.txt cache: ./cache/cord-282912-jegpgqqi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282912-jegpgqqi.txt' === file2bib.sh === id: cord-282151-mai4eggf author: Bai, Lu title: Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China date: 2015-12-16 pages: extension: .txt txt: ./txt/cord-282151-mai4eggf.txt cache: ./cache/cord-282151-mai4eggf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282151-mai4eggf.txt' === file2bib.sh === id: cord-283738-v3h7p297 author: Makar, Michael title: Gastrointestinal Findings in a Patient With COVID-19 date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-283738-v3h7p297.txt cache: ./cache/cord-283738-v3h7p297.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-283738-v3h7p297.txt' === file2bib.sh === id: cord-283806-a6exd6dn author: Menardi, Endrj title: Telemedicine during COVID‐19 pandemic date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-283806-a6exd6dn.txt cache: ./cache/cord-283806-a6exd6dn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-283806-a6exd6dn.txt' === file2bib.sh === id: cord-284163-3jmqzemf author: Seffer, Malin-Theres title: Heparin 2.0: A New Approach to the Infection Crisis date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-284163-3jmqzemf.txt cache: ./cache/cord-284163-3jmqzemf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284163-3jmqzemf.txt' === file2bib.sh === id: cord-283141-dh8j7lyl author: Haskologlu, Sule title: Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency date: 2020-03-11 pages: extension: .txt txt: ./txt/cord-283141-dh8j7lyl.txt cache: ./cache/cord-283141-dh8j7lyl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-283141-dh8j7lyl.txt' === file2bib.sh === id: cord-283513-3f4rsgzm author: Jaywant, Abhishek title: Behavioral interventions in acute COVID-19 recovery: A new opportunity for integrated care date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-283513-3f4rsgzm.txt cache: ./cache/cord-283513-3f4rsgzm.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-283513-3f4rsgzm.txt' === file2bib.sh === id: cord-282956-f7if9e5q author: Yaghi, Shadi title: SARS2-CoV-2 and Stroke in a New York Healthcare System date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-282956-f7if9e5q.txt cache: ./cache/cord-282956-f7if9e5q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282956-f7if9e5q.txt' === file2bib.sh === id: cord-282504-m3npy0om author: Kastritis, Efstathios title: Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID‐19 pandemic date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-282504-m3npy0om.txt cache: ./cache/cord-282504-m3npy0om.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282504-m3npy0om.txt' === file2bib.sh === id: cord-281566-6v5zfue6 author: Hamilos, Daniel L. title: Host-microbial interactions in patients with chronic rhinosinusitis date: 2013-11-28 pages: extension: .txt txt: ./txt/cord-281566-6v5zfue6.txt cache: ./cache/cord-281566-6v5zfue6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-281566-6v5zfue6.txt' === file2bib.sh === id: cord-283231-ju71zm7w author: Yu, Juan title: RE: Respiratory Infectious Disease in Resource Limited Setting: Radiology Management Advice date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-283231-ju71zm7w.txt cache: ./cache/cord-283231-ju71zm7w.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-283231-ju71zm7w.txt' === file2bib.sh === id: cord-283682-4fcyoyea author: Chan, Edward D. title: Mycoplasma pneumoniae-Associated Bronchiolitis Causing Severe Restrictive Lung Disease in Adults Report of Three Cases and Literature Review date: 1999-04-30 pages: extension: .txt txt: ./txt/cord-283682-4fcyoyea.txt cache: ./cache/cord-283682-4fcyoyea.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-283682-4fcyoyea.txt' === file2bib.sh === id: cord-282867-kbyxdegu author: Shah, Sayed Zulfiqar Ali title: Scaling the Need, Benefits, and Risks Associated with COVID-19 Acute and Postacute Care Rehabilitation: A Review date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-282867-kbyxdegu.txt cache: ./cache/cord-282867-kbyxdegu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282867-kbyxdegu.txt' === file2bib.sh === id: cord-283165-mdkr9qo0 author: Russell, C.D. title: Diagnosis and features of hospital-acquired pneumonia: a retrospective cohort study date: 2015-12-15 pages: extension: .txt txt: ./txt/cord-283165-mdkr9qo0.txt cache: ./cache/cord-283165-mdkr9qo0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-283165-mdkr9qo0.txt' === file2bib.sh === id: cord-284175-5rre1kbn author: Elsaid, Ossama title: Ventricular Fibrillation Storm in Coronavirus 2019 date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-284175-5rre1kbn.txt cache: ./cache/cord-284175-5rre1kbn.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-284175-5rre1kbn.txt' === file2bib.sh === id: cord-283719-zmizyx7e author: Cheng, Yuan-Yang title: Rehabilitation Programs for Patients with COronaVIrus Disease 2019: Consensus Statements of Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-283719-zmizyx7e.txt cache: ./cache/cord-283719-zmizyx7e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-283719-zmizyx7e.txt' === file2bib.sh === id: cord-285354-bp2dozzg author: Costanzi, Andrea title: In response to: Surgery in the COVID-19 phase 2 Italian scenario: Lessons learned in Northern Italy spoke hospitals date: 2020-07-01 pages: extension: .txt txt: ./txt/cord-285354-bp2dozzg.txt cache: ./cache/cord-285354-bp2dozzg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-285354-bp2dozzg.txt' === file2bib.sh === id: cord-285472-cj5r3xt1 author: Kaur, Parminder title: Acute upper limb ischemia in a patient with COVID-19 date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-285472-cj5r3xt1.txt cache: ./cache/cord-285472-cj5r3xt1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285472-cj5r3xt1.txt' === file2bib.sh === id: cord-284995-8lyr3gs4 author: Fiorina, Laurent title: COVID-19 et troubles du rythme date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-284995-8lyr3gs4.txt cache: ./cache/cord-284995-8lyr3gs4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-284995-8lyr3gs4.txt' === file2bib.sh === id: cord-285360-svczr721 author: Ganesh, Aravind title: Ignorance is not bliss: managing uncertainty in acute stroke treatment in the COVID-19 era date: 2020-10-31 pages: extension: .txt txt: ./txt/cord-285360-svczr721.txt cache: ./cache/cord-285360-svczr721.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-285360-svczr721.txt' === file2bib.sh === id: cord-282780-34j7gquo author: Lai, Kevin E. title: Tele-Neuro-Ophthalmology During the Age of COVID-19 date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-282780-34j7gquo.txt cache: ./cache/cord-282780-34j7gquo.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-282780-34j7gquo.txt' === file2bib.sh === id: cord-284042-awl5bb0j author: Carrascosa, J.M. title: Cutaneous Manifestations in the Context of SARS-CoV-2 Infection (COVID-19)() date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-284042-awl5bb0j.txt cache: ./cache/cord-284042-awl5bb0j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284042-awl5bb0j.txt' === file2bib.sh === id: cord-284576-nemh4wdo author: Sims, Jonathan T. title: Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19 date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-284576-nemh4wdo.txt cache: ./cache/cord-284576-nemh4wdo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-284576-nemh4wdo.txt' === file2bib.sh === id: cord-283583-pwlbrxn3 author: Zhang, Xiao-Ai title: Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012 date: 2015-01-09 pages: extension: .txt txt: ./txt/cord-283583-pwlbrxn3.txt cache: ./cache/cord-283583-pwlbrxn3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-283583-pwlbrxn3.txt' === file2bib.sh === id: cord-284387-cjziykrz author: Garcia-Castrillo, Luis title: European Society For Emergency Medicine position paper on emergency medical systems’ response to COVID-19 date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-284387-cjziykrz.txt cache: ./cache/cord-284387-cjziykrz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284387-cjziykrz.txt' === file2bib.sh === id: cord-283517-7gd0f06m author: Deak, Eszter title: Right-Sizing Technology in the Era of Consumer-Driven Health Care date: 2017-08-01 pages: extension: .txt txt: ./txt/cord-283517-7gd0f06m.txt cache: ./cache/cord-283517-7gd0f06m.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-283517-7gd0f06m.txt' === file2bib.sh === id: cord-283969-wqrzaxsu author: Antonucci, Michele title: The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis date: 2020-10-28 pages: extension: .txt txt: ./txt/cord-283969-wqrzaxsu.txt cache: ./cache/cord-283969-wqrzaxsu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-283969-wqrzaxsu.txt' === file2bib.sh === id: cord-284979-lyt98od1 author: Sia, Charmaine Si Min title: Critical Coronavirus Disease 2019 in a Hemodialysis Patient: A Proposed Clinical Management Strategy date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-284979-lyt98od1.txt cache: ./cache/cord-284979-lyt98od1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284979-lyt98od1.txt' === file2bib.sh === id: cord-282724-zzkqb0u2 author: Moore, Jason H. title: Ideas for how informaticians can get involved with COVID-19 research date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-282724-zzkqb0u2.txt cache: ./cache/cord-282724-zzkqb0u2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282724-zzkqb0u2.txt' === file2bib.sh === id: cord-284983-xvtkso79 author: Vigiola Cruz, Mariana title: Safety and Efficacy of Bedside Peritoneal Dialysis Catheter Placement in the COVID-19 Era: Initial Experience at a New York City Hospital date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-284983-xvtkso79.txt cache: ./cache/cord-284983-xvtkso79.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284983-xvtkso79.txt' === file2bib.sh === id: cord-283267-72wrzw09 author: Moores, Lisa K. title: Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report date: 2020-06-02 pages: extension: .txt txt: ./txt/cord-283267-72wrzw09.txt cache: ./cache/cord-283267-72wrzw09.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-283267-72wrzw09.txt' === file2bib.sh === id: cord-284545-vn60yd46 author: Sanyaolu, Adekunle title: Comorbidity and its Impact on Patients with COVID-19 date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-284545-vn60yd46.txt cache: ./cache/cord-284545-vn60yd46.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-284545-vn60yd46.txt' === file2bib.sh === id: cord-284365-g46myqe7 author: Guo, Qian title: Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-284365-g46myqe7.txt cache: ./cache/cord-284365-g46myqe7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284365-g46myqe7.txt' === file2bib.sh === id: cord-284188-ujdla954 author: Smith, Silas W. title: Virtual Urgent Care Quality and Safety in the Time of Coronavirus date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-284188-ujdla954.txt cache: ./cache/cord-284188-ujdla954.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284188-ujdla954.txt' === file2bib.sh === id: cord-284251-brn5izwo author: Melmed, Kara R. title: Risk factors for intracerebral hemorrhage in patients with COVID-19 date: 2020-09-24 pages: extension: .txt txt: ./txt/cord-284251-brn5izwo.txt cache: ./cache/cord-284251-brn5izwo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284251-brn5izwo.txt' === file2bib.sh === id: cord-284454-malfatni author: McCall, W. Travis title: Caring for Patients From a School Shooting: A Qualitative Case Series in Emergency Nursing date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-284454-malfatni.txt cache: ./cache/cord-284454-malfatni.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-284454-malfatni.txt' === file2bib.sh === id: cord-284298-tcied4l5 author: Ojeahere, Margaret Isioma title: Management of psychiatric conditions and delirium during the COVID-19 pandemic across continents: The lessons thus far date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-284298-tcied4l5.txt cache: ./cache/cord-284298-tcied4l5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-284298-tcied4l5.txt' === file2bib.sh === Traceback (most recent call last): File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexes/base.py", line 2646, in get_loc return self._engine.get_loc(key) File "pandas/_libs/index.pyx", line 111, in pandas._libs.index.IndexEngine.get_loc File "pandas/_libs/index.pyx", line 138, in pandas._libs.index.IndexEngine.get_loc File "pandas/_libs/hashtable_class_helper.pxi", line 1619, in pandas._libs.hashtable.PyObjectHashTable.get_item File "pandas/_libs/hashtable_class_helper.pxi", line 1627, in pandas._libs.hashtable.PyObjectHashTable.get_item KeyError: 'cord-266105-8avkjc84' During handling of the above exception, another exception occurred: Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/file2bib.py", line 64, in if ( bibliographics.loc[ escape ,'author'] ) : author = bibliographics.loc[ escape,'author'] File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 1762, in __getitem__ return self._getitem_tuple(key) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 1272, in _getitem_tuple return self._getitem_lowerdim(tup) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 1389, in _getitem_lowerdim section = self._getitem_axis(key, axis=i) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 1965, in _getitem_axis return self._get_label(key, axis=axis) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 625, in _get_label return self.obj._xs(label, axis=axis) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/generic.py", line 3537, in xs loc = self.index.get_loc(key) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexes/base.py", line 2648, in get_loc return self._engine.get_loc(self._maybe_cast_indexer(key)) File "pandas/_libs/index.pyx", line 111, in pandas._libs.index.IndexEngine.get_loc File "pandas/_libs/index.pyx", line 138, in pandas._libs.index.IndexEngine.get_loc File "pandas/_libs/hashtable_class_helper.pxi", line 1619, in pandas._libs.hashtable.PyObjectHashTable.get_item File "pandas/_libs/hashtable_class_helper.pxi", line 1627, in pandas._libs.hashtable.PyObjectHashTable.get_item KeyError: 'cord-266105-8avkjc84' === file2bib.sh === id: cord-269776-hj1s3ipp author: Agostoni, Angelo title: Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond date: 2004-09-11 pages: extension: .txt txt: ./txt/cord-269776-hj1s3ipp.txt cache: ./cache/cord-269776-hj1s3ipp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-269776-hj1s3ipp.txt' === file2bib.sh === id: cord-285897-ahysay2l author: Wu, Guangyao title: Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-285897-ahysay2l.txt cache: ./cache/cord-285897-ahysay2l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-285897-ahysay2l.txt' === file2bib.sh === id: cord-284526-a5kgo4ct author: Gavriilaki, Eleni title: Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-284526-a5kgo4ct.txt cache: ./cache/cord-284526-a5kgo4ct.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284526-a5kgo4ct.txt' === file2bib.sh === id: cord-285818-eh12luma author: Louis, Shreya title: Continuous Electroencephalography Characteristics and Acute Symptomatic Seizures in COVID-19 Patients date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-285818-eh12luma.txt cache: ./cache/cord-285818-eh12luma.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-285818-eh12luma.txt' === file2bib.sh === id: cord-284804-6i5zbmm1 author: Pan, Feng title: Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study date: 2020-05-18 pages: extension: .txt txt: ./txt/cord-284804-6i5zbmm1.txt cache: ./cache/cord-284804-6i5zbmm1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-284804-6i5zbmm1.txt' === file2bib.sh === id: cord-284910-vjcrhwqz author: Kirresh, Ali title: COVID-19 infection and high intracoronary thrombus burden date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-284910-vjcrhwqz.txt cache: ./cache/cord-284910-vjcrhwqz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284910-vjcrhwqz.txt' === file2bib.sh === id: cord-286227-foeb0g7u author: Potekaev, Nikolai N. title: Clinical characteristics of dermatologic manifestations of COVID‐19 infection: case series of 15 patients, review of literature, and proposed etiological classification date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-286227-foeb0g7u.txt cache: ./cache/cord-286227-foeb0g7u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-286227-foeb0g7u.txt' === file2bib.sh === id: cord-283215-dgysimh5 author: Al-Jabir, Ahmed title: Impact of the coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation) date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-283215-dgysimh5.txt cache: ./cache/cord-283215-dgysimh5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-283215-dgysimh5.txt' === file2bib.sh === id: cord-285757-fiqx4tll author: Mäkelä, M. J. title: Lack of Induction by Rhinoviruses of Systemic Type I Interferon Production or Enhanced MxA Protein Expression During the Common Cold date: 1999 pages: extension: .txt txt: ./txt/cord-285757-fiqx4tll.txt cache: ./cache/cord-285757-fiqx4tll.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285757-fiqx4tll.txt' === file2bib.sh === id: cord-285867-61y4aamj author: Kichloo, Asim title: Atezolizumab-Induced Bell’s Palsy in a Patient With Small Cell Lung Cancer date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-285867-61y4aamj.txt cache: ./cache/cord-285867-61y4aamj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285867-61y4aamj.txt' === file2bib.sh === id: cord-285469-b61y9ezi author: Hernández-Fernández, Francisco title: Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-285469-b61y9ezi.txt cache: ./cache/cord-285469-b61y9ezi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-285469-b61y9ezi.txt' === file2bib.sh === id: cord-285414-vd2d7db2 author: Yu, Qian title: Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-285414-vd2d7db2.txt cache: ./cache/cord-285414-vd2d7db2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-285414-vd2d7db2.txt' === file2bib.sh === id: cord-285755-zblitbo0 author: Zhang, F. title: Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study date: 2020-03-24 pages: extension: .txt txt: ./txt/cord-285755-zblitbo0.txt cache: ./cache/cord-285755-zblitbo0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285755-zblitbo0.txt' === file2bib.sh === id: cord-283779-mudwcypl author: Lauretani, Fulvio title: Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-283779-mudwcypl.txt cache: ./cache/cord-283779-mudwcypl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-283779-mudwcypl.txt' === file2bib.sh === id: cord-285732-xew5ar1e author: Eperjesiova, Bianka title: Spontaneous Pneumomediastinum/Pneumothorax in Patients With COVID-19 date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-285732-xew5ar1e.txt cache: ./cache/cord-285732-xew5ar1e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-285732-xew5ar1e.txt' === file2bib.sh === id: cord-285226-4ydvjmr3 author: Sekhar, Laligam N. title: The Future of Skull Base Surgery: A View Through Tinted Glasses date: 2020-06-27 pages: extension: .txt txt: ./txt/cord-285226-4ydvjmr3.txt cache: ./cache/cord-285226-4ydvjmr3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285226-4ydvjmr3.txt' === file2bib.sh === id: cord-286525-0354438s author: Lee, Todd C. title: Tocilizumab versus the covid19 tempest: all’s well that ends well or much ado about nothing? date: 2020-09-29 pages: extension: .txt txt: ./txt/cord-286525-0354438s.txt cache: ./cache/cord-286525-0354438s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-286525-0354438s.txt' === file2bib.sh === id: cord-282610-zim7nond author: Proal, Amy title: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity date: 2018-12-04 pages: extension: .txt txt: ./txt/cord-282610-zim7nond.txt cache: ./cache/cord-282610-zim7nond.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282610-zim7nond.txt' === file2bib.sh === id: cord-283826-lgyc3sro author: Stiehm, E. Richard title: Therapeutic Use of Immunoglobulins date: 2010-11-05 pages: extension: .txt txt: ./txt/cord-283826-lgyc3sro.txt cache: ./cache/cord-283826-lgyc3sro.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-283826-lgyc3sro.txt' === file2bib.sh === id: cord-286403-gdkwabcj author: Rosovsky, Rachel P. title: Diagnosis and Treatment of Pulmonary Embolism During the COVID-19 Pandemic: A Position Paper from the National PERT Consortium date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-286403-gdkwabcj.txt cache: ./cache/cord-286403-gdkwabcj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286403-gdkwabcj.txt' === file2bib.sh === id: cord-285298-r7p44wpe author: Parsonage, William A. title: CSANZ Position Statement on the Evaluation of Patients Presenting With Suspected Acute Coronary Syndromes During the COVID-19 Pandemic # date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-285298-r7p44wpe.txt cache: ./cache/cord-285298-r7p44wpe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-285298-r7p44wpe.txt' === file2bib.sh === id: cord-285291-pep4opiq author: Remy, Kenneth E. title: Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists* date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-285291-pep4opiq.txt cache: ./cache/cord-285291-pep4opiq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285291-pep4opiq.txt' === file2bib.sh === id: cord-286418-9ho5fg3h author: Jenkins, Ian title: Lessons from Walking the Medical Distancing Tightrope date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-286418-9ho5fg3h.txt cache: ./cache/cord-286418-9ho5fg3h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286418-9ho5fg3h.txt' === file2bib.sh === id: cord-285907-xoiju5ub author: Chang, Shang-Miao title: Comparative study of patients with and without SARS WHO fulfilled the WHO SARS case definition date: 2005-05-31 pages: extension: .txt txt: ./txt/cord-285907-xoiju5ub.txt cache: ./cache/cord-285907-xoiju5ub.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-285907-xoiju5ub.txt' === file2bib.sh === id: cord-285588-ug7upa3r author: Ajibade, Ayomikun title: Telemedicine in cardiovascular surgery during COVID‐19 pandemic: A systematic review and our experience date: 2020-08-16 pages: extension: .txt txt: ./txt/cord-285588-ug7upa3r.txt cache: ./cache/cord-285588-ug7upa3r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-285588-ug7upa3r.txt' === file2bib.sh === id: cord-286477-0euaaspo author: Li, Xiaochen title: Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan date: 2020-04-12 pages: extension: .txt txt: ./txt/cord-286477-0euaaspo.txt cache: ./cache/cord-286477-0euaaspo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286477-0euaaspo.txt' === file2bib.sh === id: cord-284038-93s3ffoy author: Keyhanian, Kiandokht title: SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation date: 2020-11-07 pages: extension: .txt txt: ./txt/cord-284038-93s3ffoy.txt cache: ./cache/cord-284038-93s3ffoy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284038-93s3ffoy.txt' === file2bib.sh === id: cord-286293-f5qg7vcz author: Ullah, Waqas title: COVID-19 complicated by Acute Pulmonary Embolism and Right-Sided Heart Failure date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-286293-f5qg7vcz.txt cache: ./cache/cord-286293-f5qg7vcz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286293-f5qg7vcz.txt' === file2bib.sh === id: cord-286611-e1i1wemo author: Benziger, Catherine P. title: The Telehealth Ten: A Guide for a Patient-Assisted Virtual Physical Exam date: 2020-07-18 pages: extension: .txt txt: ./txt/cord-286611-e1i1wemo.txt cache: ./cache/cord-286611-e1i1wemo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-286611-e1i1wemo.txt' === file2bib.sh === id: cord-287515-oe7adj91 author: Rello, Jordi title: Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China date: 2020-03-03 pages: extension: .txt txt: ./txt/cord-287515-oe7adj91.txt cache: ./cache/cord-287515-oe7adj91.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287515-oe7adj91.txt' === file2bib.sh === id: cord-286096-h275nner author: Huijskens, Elisabeth G. W. title: Viral and bacterial aetiology of community‐acquired pneumonia in adults date: 2012-08-22 pages: extension: .txt txt: ./txt/cord-286096-h275nner.txt cache: ./cache/cord-286096-h275nner.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-286096-h275nner.txt' === file2bib.sh === id: cord-286853-9gbel3pq author: Kim, Jiwon title: Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19 date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-286853-9gbel3pq.txt cache: ./cache/cord-286853-9gbel3pq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286853-9gbel3pq.txt' === file2bib.sh === id: cord-285467-uxfk6k3c author: Ragni, Enrico title: Management of osteoarthritis during COVID‐19 pandemic date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-285467-uxfk6k3c.txt cache: ./cache/cord-285467-uxfk6k3c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285467-uxfk6k3c.txt' === file2bib.sh === id: cord-287373-7xjn05k8 author: Lian, Xin title: Under the coronavirus disease 2019(COVID-19) pandemic circumstance, how to administrate cancer patients with fever during radiotherapy date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-287373-7xjn05k8.txt cache: ./cache/cord-287373-7xjn05k8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287373-7xjn05k8.txt' === file2bib.sh === id: cord-285772-4xt4anq5 author: Huang, Rui title: Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-285772-4xt4anq5.txt cache: ./cache/cord-285772-4xt4anq5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285772-4xt4anq5.txt' === file2bib.sh === id: cord-287048-5od0ssyk author: Areaux, Raymond G. title: Your eye doctor will virtually see you now: synchronous patient-to-provider virtual visits in pediatric tele-ophthalmology date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-287048-5od0ssyk.txt cache: ./cache/cord-287048-5od0ssyk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287048-5od0ssyk.txt' === file2bib.sh === id: cord-287117-3v9nyagt author: Monteagudo, Luke Adam title: Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-287117-3v9nyagt.txt cache: ./cache/cord-287117-3v9nyagt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-287117-3v9nyagt.txt' === file2bib.sh === id: cord-287102-o19uwryp author: Amit, Moran title: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study date: 2020-07-18 pages: extension: .txt txt: ./txt/cord-287102-o19uwryp.txt cache: ./cache/cord-287102-o19uwryp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287102-o19uwryp.txt' === file2bib.sh === id: cord-286638-bqxyb61p author: Singh, Awadhesh Kumar title: Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations date: 2020-04-09 pages: extension: .txt txt: ./txt/cord-286638-bqxyb61p.txt cache: ./cache/cord-286638-bqxyb61p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-286638-bqxyb61p.txt' === file2bib.sh === id: cord-287161-hqrql1lh author: McGrail, D. E. title: COVID-19 Case Series at UnityPoint Health St. Lukes Hospital in Cedar Rapids, IA date: 2020-07-19 pages: extension: .txt txt: ./txt/cord-287161-hqrql1lh.txt cache: ./cache/cord-287161-hqrql1lh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287161-hqrql1lh.txt' === file2bib.sh === id: cord-287468-e5h4tmy6 author: Lopez, Alexandre title: Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-287468-e5h4tmy6.txt cache: ./cache/cord-287468-e5h4tmy6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287468-e5h4tmy6.txt' === file2bib.sh === id: cord-286843-8qh1pblc author: Quah, Jessica title: Impact of microbial Aetiology on mortality in severe community-acquired pneumonia date: 2018-09-04 pages: extension: .txt txt: ./txt/cord-286843-8qh1pblc.txt cache: ./cache/cord-286843-8qh1pblc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286843-8qh1pblc.txt' === file2bib.sh === id: cord-287558-yc8aw2pg author: Duffy, Eamon Y. title: Primary and Secondary Prevention of Cardiovascular Disease in the Era of the Coronavirus Pandemic date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-287558-yc8aw2pg.txt cache: ./cache/cord-287558-yc8aw2pg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287558-yc8aw2pg.txt' === file2bib.sh === id: cord-284332-p4c1fneh author: Bosma, Karen J. title: Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date: 2012-09-19 pages: extension: .txt txt: ./txt/cord-284332-p4c1fneh.txt cache: ./cache/cord-284332-p4c1fneh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-284332-p4c1fneh.txt' === file2bib.sh === id: cord-286743-z0e5arlm author: Langer-Gould, Annette title: Early Identification of COVID-19 Cytokine Storm and Treatment with Anakinra or Tocilizumab date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-286743-z0e5arlm.txt cache: ./cache/cord-286743-z0e5arlm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-286743-z0e5arlm.txt' === file2bib.sh === id: cord-287508-133inel2 author: Vasudevan, Rajiv S. title: Persistent Value of the Stethoscope in the Age of COVID-19 date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-287508-133inel2.txt cache: ./cache/cord-287508-133inel2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287508-133inel2.txt' === file2bib.sh === id: cord-284944-hcgfe9wv author: Silvin, Aymeric title: Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19 date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-284944-hcgfe9wv.txt cache: ./cache/cord-284944-hcgfe9wv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284944-hcgfe9wv.txt' === file2bib.sh === id: cord-287786-zfe0el8i author: Dudoignon, Emmanuel title: Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19 date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-287786-zfe0el8i.txt cache: ./cache/cord-287786-zfe0el8i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287786-zfe0el8i.txt' === file2bib.sh === id: cord-287210-sars5dmi author: Woo, Patrick C. Y. title: Clinical and Molecular Epidemiological Features of Coronavirus HKU1–Associated Community-Acquired Pneumonia date: 2005-12-01 pages: extension: .txt txt: ./txt/cord-287210-sars5dmi.txt cache: ./cache/cord-287210-sars5dmi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-287210-sars5dmi.txt' === file2bib.sh === id: cord-288033-9xu1ujcq author: Zeng, Jie title: How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People’s Hospital date: 2020-03-11 pages: extension: .txt txt: ./txt/cord-288033-9xu1ujcq.txt cache: ./cache/cord-288033-9xu1ujcq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-288033-9xu1ujcq.txt' === file2bib.sh === id: cord-287520-51kmd2ds author: Carneiro, Arie title: Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-287520-51kmd2ds.txt cache: ./cache/cord-287520-51kmd2ds.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-287520-51kmd2ds.txt' === file2bib.sh === id: cord-287895-63wy5ztb author: Aponte Martín, Diego Mauricio title: Use of a new face shield for patients of the endoscopy unit to avoid aerosol exchange in the COVID-19 era date: 2020-07-04 pages: extension: .txt txt: ./txt/cord-287895-63wy5ztb.txt cache: ./cache/cord-287895-63wy5ztb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287895-63wy5ztb.txt' === file2bib.sh === id: cord-287376-wxldnlih author: Krüger, Colin M. title: Can surgery follow the dictates of the pandemic “keep your distance”? Requirements with COVID-19 for hygiene, resources and the team date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-287376-wxldnlih.txt cache: ./cache/cord-287376-wxldnlih.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287376-wxldnlih.txt' === file2bib.sh === id: cord-287222-wojyisu0 author: Zhou, Min title: Coronavirus disease 2019 (COVID-19): a clinical update date: 2020-04-02 pages: extension: .txt txt: ./txt/cord-287222-wojyisu0.txt cache: ./cache/cord-287222-wojyisu0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287222-wojyisu0.txt' === file2bib.sh === id: cord-282783-ps5jyjkl author: nan title: Full Issue PDF date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-282783-ps5jyjkl.txt cache: ./cache/cord-282783-ps5jyjkl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282783-ps5jyjkl.txt' === file2bib.sh === id: cord-287648-nhsn4cru author: Cameli, Matteo title: Usefulness of echocardiography to detect cardiac involvement in COVID‐19 patients date: 2020-07-12 pages: extension: .txt txt: ./txt/cord-287648-nhsn4cru.txt cache: ./cache/cord-287648-nhsn4cru.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287648-nhsn4cru.txt' === file2bib.sh === id: cord-287367-1sdt9zz8 author: Andrews, Denise title: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use date: 2017-10-10 pages: extension: .txt txt: ./txt/cord-287367-1sdt9zz8.txt cache: ./cache/cord-287367-1sdt9zz8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-287367-1sdt9zz8.txt' === file2bib.sh === id: cord-288158-6gicgsj8 author: Mahammedi, Abdelkader title: Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-288158-6gicgsj8.txt cache: ./cache/cord-288158-6gicgsj8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-288158-6gicgsj8.txt' === file2bib.sh === id: cord-287497-93oiiqqi author: Tagliamento, Marco title: Italian survey on managing immune checkpoint inhibitors in oncology during COVID‐19 outbreak date: 2020-06-14 pages: extension: .txt txt: ./txt/cord-287497-93oiiqqi.txt cache: ./cache/cord-287497-93oiiqqi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287497-93oiiqqi.txt' === file2bib.sh === id: cord-287544-n32iscmr author: Solaimanzadeh, Isaac title: Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19 date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-287544-n32iscmr.txt cache: ./cache/cord-287544-n32iscmr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287544-n32iscmr.txt' === file2bib.sh === id: cord-287505-ihqzpdar author: Narain, Sonali title: Comparative Survival Analysis of Immunomodulatory Therapy for COVID-19 'Cytokine Storm' date: 2020-10-17 pages: extension: .txt txt: ./txt/cord-287505-ihqzpdar.txt cache: ./cache/cord-287505-ihqzpdar.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287505-ihqzpdar.txt' === file2bib.sh === id: cord-288009-8i3gsq9p author: Javor, S. title: Why not consider an endothelin receptor antagonist against SARS‐CoV‐2? date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-288009-8i3gsq9p.txt cache: ./cache/cord-288009-8i3gsq9p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-288009-8i3gsq9p.txt' === file2bib.sh === id: cord-286607-5i406twr author: Esposito, Susanna title: The Gut Microbiota-Host Partnership as a Potential Driver of Kawasaki Syndrome date: 2019-04-05 pages: extension: .txt txt: ./txt/cord-286607-5i406twr.txt cache: ./cache/cord-286607-5i406twr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-286607-5i406twr.txt' === file2bib.sh === id: cord-288222-8fqfbys2 author: Hardy, Michaël title: Prothrombotic Disturbances of Hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Study date: 2020-10-24 pages: extension: .txt txt: ./txt/cord-288222-8fqfbys2.txt cache: ./cache/cord-288222-8fqfbys2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288222-8fqfbys2.txt' === file2bib.sh === id: cord-286237-x6dr6rsh author: Maes, Bastiaan title: Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-286237-x6dr6rsh.txt cache: ./cache/cord-286237-x6dr6rsh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286237-x6dr6rsh.txt' === file2bib.sh === id: cord-287901-56goaqir author: Maudgil, D.D. title: Cost effectiveness and the role of the National Institute of Health and Care Excellence (NICE) in interventional radiology date: 2020-10-17 pages: extension: .txt txt: ./txt/cord-287901-56goaqir.txt cache: ./cache/cord-287901-56goaqir.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287901-56goaqir.txt' === file2bib.sh === id: cord-287957-diyz54qy author: Deriba, Berhanu Senbeta title: Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-287957-diyz54qy.txt cache: ./cache/cord-287957-diyz54qy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287957-diyz54qy.txt' === file2bib.sh === id: cord-275828-c6d6nk7x author: Mikasa, Keiichi title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 pages: extension: .txt txt: ./txt/cord-275828-c6d6nk7x.txt cache: ./cache/cord-275828-c6d6nk7x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275828-c6d6nk7x.txt' === file2bib.sh === id: cord-287538-qbf5lv7d author: Nucera, Eleonora title: Latex Allergy: Current Status and Future Perspectives date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-287538-qbf5lv7d.txt cache: ./cache/cord-287538-qbf5lv7d.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287538-qbf5lv7d.txt' === file2bib.sh === id: cord-288697-9dywuhkc author: Noone, Rachel title: LETTER TO THE EDITOR: NEW ONSET PSYCHOSIS AND MANIA FOLLOWING COVID-19 INFECTION date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-288697-9dywuhkc.txt cache: ./cache/cord-288697-9dywuhkc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-288697-9dywuhkc.txt' === file2bib.sh === id: cord-288271-p074ffpt author: Mathies, D. title: A Case of SARS‐CoV‐2‐pneumonia with successful antiviral therapy in a 77‐year‐old male with heart transplant date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-288271-p074ffpt.txt cache: ./cache/cord-288271-p074ffpt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288271-p074ffpt.txt' === file2bib.sh === id: cord-288181-9thl46oe author: Fekkar, Arnaud title: Fungal Infection during COVID-19: Does Aspergillus Mean Secondary Invasive Aspergillosis? date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-288181-9thl46oe.txt cache: ./cache/cord-288181-9thl46oe.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-288181-9thl46oe.txt' === file2bib.sh === id: cord-288040-uuqfvvmk author: Kapoor, Saloni title: Developing a pediatric ophthalmology telemedicine program in the COVID-19 crisis date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-288040-uuqfvvmk.txt cache: ./cache/cord-288040-uuqfvvmk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288040-uuqfvvmk.txt' === file2bib.sh === id: cord-288102-iom6lu7o author: Han, Jing title: Analysis of factors affecting the prognosis of COVID-19 patients and viral shedding duration date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-288102-iom6lu7o.txt cache: ./cache/cord-288102-iom6lu7o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288102-iom6lu7o.txt' === file2bib.sh === id: cord-288067-36amafub author: Ashraf, Mohammad Ali title: COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-288067-36amafub.txt cache: ./cache/cord-288067-36amafub.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288067-36amafub.txt' === file2bib.sh === id: cord-287732-abzpfdcu author: Martindale, Robert title: Nutrition Therapy in Critically Ill Patients with Coronavirus Disease (COVID‐19) date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-287732-abzpfdcu.txt cache: ./cache/cord-287732-abzpfdcu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287732-abzpfdcu.txt' === file2bib.sh === id: cord-289179-3zfur0zh author: Mascarin, Maurizio title: How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-289179-3zfur0zh.txt cache: ./cache/cord-289179-3zfur0zh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289179-3zfur0zh.txt' === file2bib.sh === id: cord-287874-wl0wlxh6 author: Wang, Ling title: Quadruple therapy for asymptomatic COVID-19 infection patients date: 2020-05-03 pages: extension: .txt txt: ./txt/cord-287874-wl0wlxh6.txt cache: ./cache/cord-287874-wl0wlxh6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-287874-wl0wlxh6.txt' === file2bib.sh === id: cord-288790-5uzgenty author: Govil, Gaurav title: Rehabilitation of Arthroplasty Patient During Covid-19 date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-288790-5uzgenty.txt cache: ./cache/cord-288790-5uzgenty.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-288790-5uzgenty.txt' === file2bib.sh === id: cord-288509-l6yn2er7 author: Kalu, Peter title: The rules for online clinical engagement in the COVID era date: 2020-08-22 pages: extension: .txt txt: ./txt/cord-288509-l6yn2er7.txt cache: ./cache/cord-288509-l6yn2er7.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-288509-l6yn2er7.txt' === file2bib.sh === id: cord-288197-drto66xt author: Chen, Huijun title: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records date: 2020-02-12 pages: extension: .txt txt: ./txt/cord-288197-drto66xt.txt cache: ./cache/cord-288197-drto66xt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288197-drto66xt.txt' === file2bib.sh === id: cord-288051-wp8v2mc5 author: Sánchez-González, Álvaro title: What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-288051-wp8v2mc5.txt cache: ./cache/cord-288051-wp8v2mc5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-288051-wp8v2mc5.txt' === file2bib.sh === id: cord-288580-onzzpkye author: HALAÇLI, Burçin title: Critically ill COVID-19 patient date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-288580-onzzpkye.txt cache: ./cache/cord-288580-onzzpkye.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-288580-onzzpkye.txt' === file2bib.sh === id: cord-287953-prn8cnvo author: Shin, Nina title: Effects of operational decisions on the diffusion of epidemic disease: A system dynamics modeling of the MERS-CoV outbreak in South Korea date: 2017-05-21 pages: extension: .txt txt: ./txt/cord-287953-prn8cnvo.txt cache: ./cache/cord-287953-prn8cnvo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287953-prn8cnvo.txt' === file2bib.sh === id: cord-288575-srpc68t8 author: Yamakage, Michiaki title: Anesthesia in the times of COVID-19 date: 2020-05-25 pages: extension: .txt txt: ./txt/cord-288575-srpc68t8.txt cache: ./cache/cord-288575-srpc68t8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-288575-srpc68t8.txt' === file2bib.sh === id: cord-287742-y1j9x5ne author: Lee, Kai Wei title: Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-287742-y1j9x5ne.txt cache: ./cache/cord-287742-y1j9x5ne.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287742-y1j9x5ne.txt' === file2bib.sh === id: cord-287765-nsdequl9 author: Taiwo, Olutosin title: Smart healthcare support for remote patient monitoring during covid-19 quarantine date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-287765-nsdequl9.txt cache: ./cache/cord-287765-nsdequl9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-287765-nsdequl9.txt' === file2bib.sh === id: cord-288606-h8pmqwmk author: Alhmoud, Eman title: Anticoagulation clinic drive-up service during COVID-19 pandemic in Qatar date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-288606-h8pmqwmk.txt cache: ./cache/cord-288606-h8pmqwmk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-288606-h8pmqwmk.txt' === file2bib.sh === id: cord-289046-frhpt8n9 author: Fix, Oren K. title: Telemedicine and Telehepatology During the COVID‐19 Pandemic date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-289046-frhpt8n9.txt cache: ./cache/cord-289046-frhpt8n9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289046-frhpt8n9.txt' === file2bib.sh === id: cord-286683-mettlmhz author: Ortiz-Prado, Esteban title: Clinical, molecular and epidemiological characterization of the SARS-CoV2 virus and the Coronavirus disease 2019 (COVID-19), a comprehensive literature review date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-286683-mettlmhz.txt cache: ./cache/cord-286683-mettlmhz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286683-mettlmhz.txt' === file2bib.sh === id: cord-288558-rthnj6wd author: Cheng, V. C. C. title: Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome date: 2004-02-15 pages: extension: .txt txt: ./txt/cord-288558-rthnj6wd.txt cache: ./cache/cord-288558-rthnj6wd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-288558-rthnj6wd.txt' === file2bib.sh === id: cord-287991-10jz1dz2 author: Goshen-Lago, Tal title: The Potential Role of Immune Alteration in the Cancer–COVID19 Equation—A Prospective Longitudinal Study date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-287991-10jz1dz2.txt cache: ./cache/cord-287991-10jz1dz2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-287991-10jz1dz2.txt' === file2bib.sh === id: cord-289054-fh95b5n4 author: Au Yong, Phui S. title: Reducing droplet spread during airway manipulation: lessons from the COVID-19 pandemic in Singapore date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-289054-fh95b5n4.txt cache: ./cache/cord-289054-fh95b5n4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289054-fh95b5n4.txt' === file2bib.sh === id: cord-286574-t9z2ynt5 author: nan title: Speaker presentations date: 2017-09-30 pages: extension: .txt txt: ./txt/cord-286574-t9z2ynt5.txt cache: ./cache/cord-286574-t9z2ynt5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286574-t9z2ynt5.txt' === file2bib.sh === id: cord-289006-7dv1zsp9 author: Tan, Kimberly-Anne title: Addressing Coronavirus Disease 2019 in Spine Surgery: A Rapid National Consensus Using the Delphi Method via Teleconference date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-289006-7dv1zsp9.txt cache: ./cache/cord-289006-7dv1zsp9.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289006-7dv1zsp9.txt' === file2bib.sh === id: cord-289219-qjxdggz3 author: Sebio-García, Raquel title: Pulmonary Rehabilitation: Time for an Upgrade date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-289219-qjxdggz3.txt cache: ./cache/cord-289219-qjxdggz3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289219-qjxdggz3.txt' === file2bib.sh === id: cord-288810-ab7k70c4 author: Zheng, Yingyan title: Development and Validation of a Prognostic Nomogram Based on Clinical and CT Features for Adverse Outcome Prediction in Patients with COVID-19 date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-288810-ab7k70c4.txt cache: ./cache/cord-288810-ab7k70c4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-288810-ab7k70c4.txt' === file2bib.sh === id: cord-289088-7uoia564 author: Ding, Qiang title: The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China date: 2020-03-30 pages: extension: .txt txt: ./txt/cord-289088-7uoia564.txt cache: ./cache/cord-289088-7uoia564.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289088-7uoia564.txt' === file2bib.sh === id: cord-289064-435bp4rt author: Muniangi-Muhitu, Hermine title: Covid-19 and Diabetes: A Complex Bidirectional Relationship date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-289064-435bp4rt.txt cache: ./cache/cord-289064-435bp4rt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289064-435bp4rt.txt' === file2bib.sh === id: cord-289115-bntcn0m6 author: Thangaraju, Pugazhenthan title: Role of Dupilumab in Approved Indications of COVID-19 Patient: an Efficacy-Based Nonsystematic Critical Analysis date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-289115-bntcn0m6.txt cache: ./cache/cord-289115-bntcn0m6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289115-bntcn0m6.txt' === file2bib.sh === id: cord-289169-3u7qgxud author: Fang, Xiaowei title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-289169-3u7qgxud.txt cache: ./cache/cord-289169-3u7qgxud.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289169-3u7qgxud.txt' === file2bib.sh === id: cord-286334-d9v5xtx7 author: Li, Rui title: Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-286334-d9v5xtx7.txt cache: ./cache/cord-286334-d9v5xtx7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-286334-d9v5xtx7.txt' === file2bib.sh === id: cord-289311-0wgafqdz author: Kim, Jee-Eun title: Neurological Complications during Treatment of Middle East Respiratory Syndrome date: 2017-06-30 pages: extension: .txt txt: ./txt/cord-289311-0wgafqdz.txt cache: ./cache/cord-289311-0wgafqdz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-289311-0wgafqdz.txt' === file2bib.sh === id: cord-288552-7lp07v5i author: Vahedi, Ensieh title: The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-288552-7lp07v5i.txt cache: ./cache/cord-288552-7lp07v5i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-288552-7lp07v5i.txt' === file2bib.sh === id: cord-289719-64ugdvfe author: Tenforde, Mark W. title: Characteristics of Adult Outpatients and Inpatients with COVID-19 — 11 Academic Medical Centers, United States, March–May 2020 date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-289719-64ugdvfe.txt cache: ./cache/cord-289719-64ugdvfe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-289719-64ugdvfe.txt' === file2bib.sh === id: cord-288255-p8uzrsbd author: Goossens, Gijs H. title: Obesity and COVID-19: A Perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-288255-p8uzrsbd.txt cache: ./cache/cord-288255-p8uzrsbd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288255-p8uzrsbd.txt' === file2bib.sh === id: cord-289859-b1k9uyp6 author: Hodges, Kevin title: Successful management of COVID‐19 and associated coagulopathy in a patient with durable left ventricular assist device date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-289859-b1k9uyp6.txt cache: ./cache/cord-289859-b1k9uyp6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289859-b1k9uyp6.txt' === file2bib.sh === id: cord-289690-af6lsj1g author: Svobodova, Tamara title: Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date: 2015-02-10 pages: extension: .txt txt: ./txt/cord-289690-af6lsj1g.txt cache: ./cache/cord-289690-af6lsj1g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-289690-af6lsj1g.txt' === file2bib.sh === id: cord-289816-rlwoy8ms author: Tedeschi, Delio title: Acute myocardial infarction and large coronary thrombosis in a patient with COVID‐19 date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-289816-rlwoy8ms.txt cache: ./cache/cord-289816-rlwoy8ms.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289816-rlwoy8ms.txt' === file2bib.sh === id: cord-288371-uyj4iske author: Arrieta, Oscar title: Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: The THOCOoP cooperative group date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-288371-uyj4iske.txt cache: ./cache/cord-288371-uyj4iske.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288371-uyj4iske.txt' === file2bib.sh === id: cord-289553-gygvhzcc author: Alvarez, Roger A. title: Home Nitric Oxide Therapy for COVID-19 date: 2020-07-01 pages: extension: .txt txt: ./txt/cord-289553-gygvhzcc.txt cache: ./cache/cord-289553-gygvhzcc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289553-gygvhzcc.txt' === file2bib.sh === id: cord-289457-06gwrpu0 author: Berth, Sarah H. title: Secondary Causes of Myositis date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-289457-06gwrpu0.txt cache: ./cache/cord-289457-06gwrpu0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289457-06gwrpu0.txt' === file2bib.sh === id: cord-289828-3k088z9n author: De Salvo, Andrea title: How to be together and carry on our project activities during COVID‐19 pandemic in Rome date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-289828-3k088z9n.txt cache: ./cache/cord-289828-3k088z9n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289828-3k088z9n.txt' === file2bib.sh === id: cord-019347-tj3ye1mx author: nan title: ABSTRACT BOOK date: 2010-02-19 pages: extension: .txt txt: ./txt/cord-019347-tj3ye1mx.txt cache: ./cache/cord-019347-tj3ye1mx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-019347-tj3ye1mx.txt' === file2bib.sh === id: cord-289854-p8okfa4b author: Flores, Gabriel title: Spontaneous Brainstem Hemorrhagic Stroke in the Setting of Novel Coronavirus Disease 2019 – A Case Report date: 2020-10-05 pages: extension: .txt txt: ./txt/cord-289854-p8okfa4b.txt cache: ./cache/cord-289854-p8okfa4b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289854-p8okfa4b.txt' === file2bib.sh === id: cord-289322-5ciaonf0 author: Chen, X. title: Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study date: 2020-03-06 pages: extension: .txt txt: ./txt/cord-289322-5ciaonf0.txt cache: ./cache/cord-289322-5ciaonf0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-289322-5ciaonf0.txt' === file2bib.sh === id: cord-289574-engwi8h3 author: An, Peng-jiao title: Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-289574-engwi8h3.txt cache: ./cache/cord-289574-engwi8h3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289574-engwi8h3.txt' === file2bib.sh === id: cord-290041-zxlq63n5 author: Srivastava, Arnav title: Delaying Surgery for Clinical T1b-T2bN0M0 Renal Cell Carcinoma: Oncologic Implications in the COVID-19 Era and Beyond date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-290041-zxlq63n5.txt cache: ./cache/cord-290041-zxlq63n5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290041-zxlq63n5.txt' === file2bib.sh === id: cord-289542-u86ujtur author: Razavian, Narges title: A validated, real-time prediction model for favorable outcomes in hospitalized COVID-19 patients date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-289542-u86ujtur.txt cache: ./cache/cord-289542-u86ujtur.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-289542-u86ujtur.txt' === file2bib.sh === id: cord-289930-7xm6q68s author: Li, Yang title: Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational study date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-289930-7xm6q68s.txt cache: ./cache/cord-289930-7xm6q68s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289930-7xm6q68s.txt' === file2bib.sh === id: cord-289533-hip9qtu5 author: Smulever, Anabella title: Thyroid cancer in the Era of COVID-19 date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-289533-hip9qtu5.txt cache: ./cache/cord-289533-hip9qtu5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289533-hip9qtu5.txt' === file2bib.sh === id: cord-290065-ouua7wnq author: Kashi, Mahine title: Severe arterial thrombosis associated with Covid-19 infection date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-290065-ouua7wnq.txt cache: ./cache/cord-290065-ouua7wnq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-290065-ouua7wnq.txt' === file2bib.sh === id: cord-289806-6ihptx6n author: Martinez, Rebecca title: Critical Obstetric Patients During the Coronavirus Disease 2019 Pandemic: Operationalizing an Obstetric Intensive Care Unit date: 2020-10-07 pages: extension: .txt txt: ./txt/cord-289806-6ihptx6n.txt cache: ./cache/cord-289806-6ihptx6n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-289806-6ihptx6n.txt' === file2bib.sh === id: cord-290006-63sa00ju author: Ko, Jane P. title: Approach to Peribronchovascular Disease on CT date: 2018-12-20 pages: extension: .txt txt: ./txt/cord-290006-63sa00ju.txt cache: ./cache/cord-290006-63sa00ju.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290006-63sa00ju.txt' === file2bib.sh === id: cord-290051-22gwwrpw author: Masaki, Shigenori title: Endotracheal intubation in patients with COVID-19 using an ultrathin flexible gastrointestinal endoscope date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-290051-22gwwrpw.txt cache: ./cache/cord-290051-22gwwrpw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290051-22gwwrpw.txt' === file2bib.sh === id: cord-290551-a02tueuu author: Singh, Shailendra title: Impact of Obesity on Outcomes of Patients with COVID-19 in United States: A Multicenter Electronic Health Records Network Study. date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-290551-a02tueuu.txt cache: ./cache/cord-290551-a02tueuu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-290551-a02tueuu.txt' === file2bib.sh === id: cord-290712-flj352ql author: Bi, Jianping title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-290712-flj352ql.txt cache: ./cache/cord-290712-flj352ql.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290712-flj352ql.txt' === file2bib.sh === id: cord-290081-pjg00t7g author: Dunkerley, Sarah title: Patient care modifications and hospital regulations during the COVID-19 crisis created inequality and functional hazard for patients with orthopaedic trauma date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-290081-pjg00t7g.txt cache: ./cache/cord-290081-pjg00t7g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-290081-pjg00t7g.txt' === file2bib.sh === id: cord-290401-t87i3exo author: Bassetti, Matteo title: Principles of antimicrobial stewardship for bacterial and fungal infections in ICU date: 2017-09-12 pages: extension: .txt txt: ./txt/cord-290401-t87i3exo.txt cache: ./cache/cord-290401-t87i3exo.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290401-t87i3exo.txt' === file2bib.sh === id: cord-290200-csmisulw author: Friedlaender, Alex title: Rethinking the Optimal Duration of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer Throughout the COVID-19 Pandemic date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-290200-csmisulw.txt cache: ./cache/cord-290200-csmisulw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-290200-csmisulw.txt' === file2bib.sh === id: cord-290750-85731og8 author: Danese, Silvio title: Management of IBD during the COVID-19 outbreak: resetting clinical priorities date: 2020-03-25 pages: extension: .txt txt: ./txt/cord-290750-85731og8.txt cache: ./cache/cord-290750-85731og8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-290750-85731og8.txt' === file2bib.sh === id: cord-291052-nstfe15a author: Cag, Yasemin title: A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-291052-nstfe15a.txt cache: ./cache/cord-291052-nstfe15a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291052-nstfe15a.txt' === file2bib.sh === id: cord-291265-qmylxndp author: Moravvej, Zahra title: COVID-19 pandemic: Ophthalmic practice and precautions in a tertiary eye hospital in Iran date: 2020-04-23 pages: extension: .txt txt: ./txt/cord-291265-qmylxndp.txt cache: ./cache/cord-291265-qmylxndp.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-291265-qmylxndp.txt' === file2bib.sh === id: cord-291016-c83fs5ih author: Gori, Tommaso title: Perspective: cardiovascular disease and the Covid-19 pandemic date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-291016-c83fs5ih.txt cache: ./cache/cord-291016-c83fs5ih.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291016-c83fs5ih.txt' === file2bib.sh === id: cord-290295-gl144dh9 author: Martínez-López, Joaquín title: Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality date: 2020-10-19 pages: extension: .txt txt: ./txt/cord-290295-gl144dh9.txt cache: ./cache/cord-290295-gl144dh9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290295-gl144dh9.txt' === file2bib.sh === id: cord-289973-1mczuxsy author: Biran, Noa title: Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-289973-1mczuxsy.txt cache: ./cache/cord-289973-1mczuxsy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289973-1mczuxsy.txt' === file2bib.sh === id: cord-290975-2kmvyovm author: Martinotti, Giovanni title: Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-290975-2kmvyovm.txt cache: ./cache/cord-290975-2kmvyovm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-290975-2kmvyovm.txt' === file2bib.sh === id: cord-290658-r2bqqovo author: Qian, Hao title: Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: a Retrospective in-ICU Study date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-290658-r2bqqovo.txt cache: ./cache/cord-290658-r2bqqovo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290658-r2bqqovo.txt' === file2bib.sh === id: cord-290267-ke696q8j author: Fang, Huilin title: Impact of comorbidities on clinical prognosis in 1280 patients with different types of COVID-19 date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-290267-ke696q8j.txt cache: ./cache/cord-290267-ke696q8j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290267-ke696q8j.txt' === file2bib.sh === id: cord-290341-ei768v4s author: Anstey, D. Edmund title: The cardiac intensive care unit and the cardiac Intensivist during the COVID-19 surge in New York City() date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-290341-ei768v4s.txt cache: ./cache/cord-290341-ei768v4s.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-290341-ei768v4s.txt' === file2bib.sh === id: cord-290326-umv0q4d7 author: Stachowska, Ewa title: Nutritional Support in Coronavirus 2019 Disease date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-290326-umv0q4d7.txt cache: ./cache/cord-290326-umv0q4d7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290326-umv0q4d7.txt' === file2bib.sh === id: cord-290947-5ewpvo4j author: Carda, Stefano title: The role of physical and rehabilitation medicine in the COVID-19 pandemic: the clinician's view date: 2020-04-18 pages: extension: .txt txt: ./txt/cord-290947-5ewpvo4j.txt cache: ./cache/cord-290947-5ewpvo4j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-290947-5ewpvo4j.txt' === file2bib.sh === id: cord-289114-ifnk41oq author: Singh, Angaraj title: Effect of pre‐existing diseases on COVID‐19 infection and role of new sensors and biomaterials for its detection and treatment date: 2020-10-28 pages: extension: .txt txt: ./txt/cord-289114-ifnk41oq.txt cache: ./cache/cord-289114-ifnk41oq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289114-ifnk41oq.txt' === file2bib.sh === id: cord-291469-cohrewj5 author: Cortese, Bernardo title: How is the cardiovascular patient managed during Covid‐19 pandemic? A report from the frontline date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-291469-cohrewj5.txt cache: ./cache/cord-291469-cohrewj5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-291469-cohrewj5.txt' === file2bib.sh === id: cord-290028-oyd7vzj6 author: Unruh, Mark title: Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-290028-oyd7vzj6.txt cache: ./cache/cord-290028-oyd7vzj6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-290028-oyd7vzj6.txt' === file2bib.sh === id: cord-290611-fhaguv3f author: Ghio, Stefano title: Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hospital in Northern Italy date: 2020-09-22 pages: extension: .txt txt: ./txt/cord-290611-fhaguv3f.txt cache: ./cache/cord-290611-fhaguv3f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290611-fhaguv3f.txt' === file2bib.sh === id: cord-289612-4x5t4c5u author: Alsuliman, Tamim title: COVID-19 paraclinical diagnostic tools: Updates and future trends date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-289612-4x5t4c5u.txt cache: ./cache/cord-289612-4x5t4c5u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289612-4x5t4c5u.txt' === file2bib.sh === id: cord-291340-8gj0ofmp author: Misra, Anoop title: Balanced Nutrition is Needed in Times of COVID19 Epidemic in India: A Call for Action for all Nutritionists and Physicians date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-291340-8gj0ofmp.txt cache: ./cache/cord-291340-8gj0ofmp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291340-8gj0ofmp.txt' === file2bib.sh === id: cord-290836-jldfrec9 author: Laosa, Olga title: Rapid assessment at hospital admission of mortality risk from COVID-19: the role of functional status date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-290836-jldfrec9.txt cache: ./cache/cord-290836-jldfrec9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290836-jldfrec9.txt' === file2bib.sh === id: cord-291244-o4isx15k author: Ikuyama, Yuichi title: Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date: 2020-05-31 pages: extension: .txt txt: ./txt/cord-291244-o4isx15k.txt cache: ./cache/cord-291244-o4isx15k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-291244-o4isx15k.txt' === file2bib.sh === id: cord-290856-6de0mwg0 author: Abbo, Aharon (Ronnie) title: Technological Developments and Strategic Management for Overcoming the COVID-19 Challenge within the Hospital Setting in Israel date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-290856-6de0mwg0.txt cache: ./cache/cord-290856-6de0mwg0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290856-6de0mwg0.txt' === file2bib.sh === id: cord-290195-8uaai9nv author: Stebbing, Justin title: Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-290195-8uaai9nv.txt cache: ./cache/cord-290195-8uaai9nv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-290195-8uaai9nv.txt' === file2bib.sh === id: cord-289008-c4cu3vrp author: Wallis, Christopher J.D. title: Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic date: 2020-05-03 pages: extension: .txt txt: ./txt/cord-289008-c4cu3vrp.txt cache: ./cache/cord-289008-c4cu3vrp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289008-c4cu3vrp.txt' === file2bib.sh === id: cord-291024-9g4om4sf author: Isakbaeva, Elmira T. title: SARS-associated Coronavirus Transmission, United States date: 2004-02-17 pages: extension: .txt txt: ./txt/cord-291024-9g4om4sf.txt cache: ./cache/cord-291024-9g4om4sf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-291024-9g4om4sf.txt' === file2bib.sh === id: cord-291686-kgewmqg5 author: Patel, Surendra title: Prioritizing cardiovascular surgical care in COVID‐19 pandemic: Shall we operate or defer? date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-291686-kgewmqg5.txt cache: ./cache/cord-291686-kgewmqg5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291686-kgewmqg5.txt' === file2bib.sh === id: cord-291168-4u4cssky author: Martin-Villares, Cristina title: Outcome of 1890 tracheostomies for critical COVID-19 patients: a national cohort study in Spain date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-291168-4u4cssky.txt cache: ./cache/cord-291168-4u4cssky.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291168-4u4cssky.txt' === file2bib.sh === id: cord-289852-4uxb70rh author: Kassem, Dina H. title: Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-289852-4uxb70rh.txt cache: ./cache/cord-289852-4uxb70rh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289852-4uxb70rh.txt' === file2bib.sh === id: cord-290832-zmj59rc3 author: Recinella, Guerino title: Prognostic role of nutritional status in elderly patients hospitalized for COVID-19: a monocentric study date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-290832-zmj59rc3.txt cache: ./cache/cord-290832-zmj59rc3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-290832-zmj59rc3.txt' === file2bib.sh === id: cord-291025-u5z8zji3 author: Karami, Parisa title: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-291025-u5z8zji3.txt cache: ./cache/cord-291025-u5z8zji3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291025-u5z8zji3.txt' === file2bib.sh === id: cord-290771-18dj37dj author: Tzeng, Ching-Wei D. title: Cancer Surgery Scheduling During and After the COVID-19 First Wave: The MD Anderson Cancer Center Experience date: 2020-05-18 pages: extension: .txt txt: ./txt/cord-290771-18dj37dj.txt cache: ./cache/cord-290771-18dj37dj.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-290771-18dj37dj.txt' === file2bib.sh === id: cord-287758-da11ypiy author: Mônica Vitalino de Almeida, Sinara title: COVID-19 therapy: what weapons do we bring into battle? date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-287758-da11ypiy.txt cache: ./cache/cord-287758-da11ypiy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-287758-da11ypiy.txt' === file2bib.sh === id: cord-276758-k2imddzr author: Siegel, Jane D. title: 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings date: 2007-12-07 pages: extension: .txt txt: ./txt/cord-276758-k2imddzr.txt cache: ./cache/cord-276758-k2imddzr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-276758-k2imddzr.txt' === file2bib.sh === id: cord-291176-evb6yt0r author: Giorgi Rossi, Paolo title: Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-291176-evb6yt0r.txt cache: ./cache/cord-291176-evb6yt0r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291176-evb6yt0r.txt' === file2bib.sh === id: cord-292056-dtdyxhq4 author: Ghogawala, Zoher title: Editorial. COVID-19 and spinal surgery date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-292056-dtdyxhq4.txt cache: ./cache/cord-292056-dtdyxhq4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-292056-dtdyxhq4.txt' === file2bib.sh === id: cord-291388-tt9eq7e0 author: Wang, Jann-Tay title: Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients date: 2004-05-17 pages: extension: .txt txt: ./txt/cord-291388-tt9eq7e0.txt cache: ./cache/cord-291388-tt9eq7e0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291388-tt9eq7e0.txt' === file2bib.sh === id: cord-291413-cgec7150 author: Al-Jehani, Hosam title: MENA-SINO Consensus Statement on Implementing Care Pathways for Acute Neurovascular Emergencies During the COVID-19 Pandemic date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-291413-cgec7150.txt cache: ./cache/cord-291413-cgec7150.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291413-cgec7150.txt' === file2bib.sh === id: cord-291417-p49ukyhx author: Mikulska, Malgorzata title: Tocilizumab and steroid treatment in patients with COVID-19 pneumonia date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-291417-p49ukyhx.txt cache: ./cache/cord-291417-p49ukyhx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291417-p49ukyhx.txt' === file2bib.sh === id: cord-291430-rsu6xviv author: Zhang, Qian title: A Mysterious Paratracheal Mass: Parathyroid Carcinoma date: 2020-07-11 pages: extension: .txt txt: ./txt/cord-291430-rsu6xviv.txt cache: ./cache/cord-291430-rsu6xviv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291430-rsu6xviv.txt' === file2bib.sh === id: cord-291873-inzzywps author: Tognetto, Daniele title: Managing ophthalmic practices in a referral emergency COVID‐19 hospital in north‐east Italy date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-291873-inzzywps.txt cache: ./cache/cord-291873-inzzywps.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291873-inzzywps.txt' === file2bib.sh === id: cord-292345-zc209dfx author: Carroll, Elizabeth title: Catastrophic Intracranial Hemorrhage in Two Critically Ill Patients with COVID-19 date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-292345-zc209dfx.txt cache: ./cache/cord-292345-zc209dfx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-292345-zc209dfx.txt' === file2bib.sh === id: cord-291855-wtwz94sy author: Tambone, Vittoradolfo title: Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-291855-wtwz94sy.txt cache: ./cache/cord-291855-wtwz94sy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-291855-wtwz94sy.txt' === file2bib.sh === id: cord-291397-look6ddt author: Roberto, Palumbo title: Current treatment of COVID-19 in renal patients: hope or hype? date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-291397-look6ddt.txt cache: ./cache/cord-291397-look6ddt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291397-look6ddt.txt' === file2bib.sh === id: cord-292394-91b3mm6c author: Ashish, A. title: Early CPAP reduced mortality in covid-19 patients. Audit results from Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust. date: 2020-06-02 pages: extension: .txt txt: ./txt/cord-292394-91b3mm6c.txt cache: ./cache/cord-292394-91b3mm6c.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292394-91b3mm6c.txt' === file2bib.sh === id: cord-292620-t8ocqm6g author: Somani, S. title: Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19 date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-292620-t8ocqm6g.txt cache: ./cache/cord-292620-t8ocqm6g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-292620-t8ocqm6g.txt' === file2bib.sh === id: cord-292493-lx7zfgoi author: Firstenberg, Michael S. title: Isolation protocol for a COVID-2019 patient requiring emergent surgical intervention: case presentation date: 2020-04-19 pages: extension: .txt txt: ./txt/cord-292493-lx7zfgoi.txt cache: ./cache/cord-292493-lx7zfgoi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292493-lx7zfgoi.txt' === file2bib.sh === id: cord-292054-x0saq938 author: Hashizume, Misato title: Outlook of IL-6 signaling blockade for COVID-19 pneumonia date: 2020-10-05 pages: extension: .txt txt: ./txt/cord-292054-x0saq938.txt cache: ./cache/cord-292054-x0saq938.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-292054-x0saq938.txt' === file2bib.sh === id: cord-291588-tp89j1kk author: Dorche, Maryam Sharifian title: Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-291588-tp89j1kk.txt cache: ./cache/cord-291588-tp89j1kk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291588-tp89j1kk.txt' === file2bib.sh === id: cord-291566-jwlvustd author: Wells Mulherin, Diana title: ASPEN Report on Nutrition Support Practice Processes With COVID‐19: The First Response date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-291566-jwlvustd.txt cache: ./cache/cord-291566-jwlvustd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291566-jwlvustd.txt' === file2bib.sh === id: cord-292826-lus0tqmi author: Joseph, Tony title: Trauma care in a low-COVID pandemic environment: A new normal date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-292826-lus0tqmi.txt cache: ./cache/cord-292826-lus0tqmi.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292826-lus0tqmi.txt' === file2bib.sh === id: cord-293285-w8c3ma8l author: Lanza, F title: Reflection on passive immunotherapy in those who need most: some novel strategic arguments for obtaining safer therapeutic plasma or autologous antibodies from recovered COVID ‐19 infected patients date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-293285-w8c3ma8l.txt cache: ./cache/cord-293285-w8c3ma8l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293285-w8c3ma8l.txt' === file2bib.sh === id: cord-291624-fod0eyuj author: Malone, Robert W. title: COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-291624-fod0eyuj.txt cache: ./cache/cord-291624-fod0eyuj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291624-fod0eyuj.txt' === file2bib.sh === id: cord-291697-wpnq9wc0 author: Riechelmann, Rachel P title: Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-291697-wpnq9wc0.txt cache: ./cache/cord-291697-wpnq9wc0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291697-wpnq9wc0.txt' === file2bib.sh === id: cord-293143-1k170shh author: Dieninghoff, Doris title: Fatal HBoV-1 infection in adult female cystic fibrosis patient date: 2016-07-18 pages: extension: .txt txt: ./txt/cord-293143-1k170shh.txt cache: ./cache/cord-293143-1k170shh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-293143-1k170shh.txt' === file2bib.sh === id: cord-292335-al6v3b9x author: Crotty, Matthew P. title: Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship date: 2015-11-18 pages: extension: .txt txt: ./txt/cord-292335-al6v3b9x.txt cache: ./cache/cord-292335-al6v3b9x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292335-al6v3b9x.txt' === file2bib.sh === id: cord-291687-kwu0otpi author: Judson, Gregory L. title: Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection date: 2020-06-13 pages: extension: .txt txt: ./txt/cord-291687-kwu0otpi.txt cache: ./cache/cord-291687-kwu0otpi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291687-kwu0otpi.txt' === file2bib.sh === id: cord-292485-vk5xy3zn author: Prasad, Narayan title: The adverse effect of COVID pandemic on the care of patients with kidney diseases in India date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-292485-vk5xy3zn.txt cache: ./cache/cord-292485-vk5xy3zn.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-292485-vk5xy3zn.txt' === file2bib.sh === id: cord-292952-z7ajsf2r author: Wong, Anselm title: COVID‐19 and toxicity from potential treatments: Panacea or poison date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-292952-z7ajsf2r.txt cache: ./cache/cord-292952-z7ajsf2r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292952-z7ajsf2r.txt' === file2bib.sh === id: cord-289581-aozg3o9o author: nan title: Abstracts der 54. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date: 2016-08-25 pages: extension: .txt txt: ./txt/cord-289581-aozg3o9o.txt cache: ./cache/cord-289581-aozg3o9o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-289581-aozg3o9o.txt' === file2bib.sh === id: cord-292561-iy06b9h9 author: Miesbach, Wolfgang title: COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-292561-iy06b9h9.txt cache: ./cache/cord-292561-iy06b9h9.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-292561-iy06b9h9.txt' === file2bib.sh === id: cord-292474-dmgd99d6 author: Berardi, Giammauro title: Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-292474-dmgd99d6.txt cache: ./cache/cord-292474-dmgd99d6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-292474-dmgd99d6.txt' === file2bib.sh === id: cord-293575-h3wc7j4v author: Adrish, Muhammad title: Association of smoking status with outcomes in hospitalised patients with COVID-19 date: 2020-10-05 pages: extension: .txt txt: ./txt/cord-293575-h3wc7j4v.txt cache: ./cache/cord-293575-h3wc7j4v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293575-h3wc7j4v.txt' === file2bib.sh === id: cord-293180-f1ulk9ce author: Li, R W K title: Severe Acute Respiratory Syndrome (SARS) and the GDP. Part II: Implications for GDPs date: 2004-08-14 pages: extension: .txt txt: ./txt/cord-293180-f1ulk9ce.txt cache: ./cache/cord-293180-f1ulk9ce.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293180-f1ulk9ce.txt' === file2bib.sh === id: cord-291670-mqj071gp author: Raredon, M. S. B. title: Pressure-Regulated Ventilator Splitting (PReVentS): A COVID-19 Response Paradigm from Yale University date: 2020-04-06 pages: extension: .txt txt: ./txt/cord-291670-mqj071gp.txt cache: ./cache/cord-291670-mqj071gp.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291670-mqj071gp.txt' === file2bib.sh === id: cord-292387-2xv3wgaq author: D′Agostino, Armando title: Brief Psychotic Disorder During the National Lockdown in Italy: An Emerging Clinical Phenomenon of the COVID-19 Pandemic date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-292387-2xv3wgaq.txt cache: ./cache/cord-292387-2xv3wgaq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292387-2xv3wgaq.txt' === file2bib.sh === id: cord-292350-cmrtg91a author: Mondal, Samhati title: Thromboembolic disease in COVID-19 patients: A brief narrative review date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-292350-cmrtg91a.txt cache: ./cache/cord-292350-cmrtg91a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292350-cmrtg91a.txt' === file2bib.sh === id: cord-293964-hz5uow2b author: Hermann, Matthias title: Feasibility and Efficacy of Cardiopulmonary Rehabilitation following COVID-19 date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-293964-hz5uow2b.txt cache: ./cache/cord-293964-hz5uow2b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-293964-hz5uow2b.txt' === file2bib.sh === id: cord-294057-fbox3a5q author: Schlegl, Sandra title: Bulimia nervosa in times of the COVID‐19 pandemic—Results from an online survey of former inpatients date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-294057-fbox3a5q.txt cache: ./cache/cord-294057-fbox3a5q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294057-fbox3a5q.txt' === file2bib.sh === id: cord-294487-hcuzxhb3 author: Shenoi, Susan title: Telemedicine in pediatric rheumatology: this is the time for the community to embrace a new way of clinical practice date: 2020-10-31 pages: extension: .txt txt: ./txt/cord-294487-hcuzxhb3.txt cache: ./cache/cord-294487-hcuzxhb3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294487-hcuzxhb3.txt' === file2bib.sh === id: cord-293570-gh6ykmea author: Gupta, Rajib K. title: Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease: a report of 2 cases date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-293570-gh6ykmea.txt cache: ./cache/cord-293570-gh6ykmea.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293570-gh6ykmea.txt' === file2bib.sh === id: cord-293730-dlqo6fep author: Caratozzolo, Salvatore title: The impact of COVID-19 on health status of home-dwelling elderly patients with dementia in East Lombardy, Italy: results from COVIDEM network date: 2020-09-12 pages: extension: .txt txt: ./txt/cord-293730-dlqo6fep.txt cache: ./cache/cord-293730-dlqo6fep.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293730-dlqo6fep.txt' === file2bib.sh === id: cord-292315-7vwybku8 author: Jung, Gyuwon title: Too Much Information: Assessing Privacy Risks of Contact Trace Data Disclosure on People With COVID-19 in South Korea date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-292315-7vwybku8.txt cache: ./cache/cord-292315-7vwybku8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-292315-7vwybku8.txt' === file2bib.sh === id: cord-293522-gg706q8s author: Toumi, Mondher title: Commentary on “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial” by Gautret et al date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-293522-gg706q8s.txt cache: ./cache/cord-293522-gg706q8s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-293522-gg706q8s.txt' === file2bib.sh === id: cord-293086-6282sb6b author: Liddell, Kathleen title: Who gets the ventilator? Important legal rights in a pandemic date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-293086-6282sb6b.txt cache: ./cache/cord-293086-6282sb6b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-293086-6282sb6b.txt' === file2bib.sh === id: cord-293167-3bd3adip author: Nepal, Gaurav title: Neurological manifestations of COVID-19: a systematic review date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-293167-3bd3adip.txt cache: ./cache/cord-293167-3bd3adip.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293167-3bd3adip.txt' === file2bib.sh === id: cord-293333-mqoml9o5 author: Scharbarg, Emeric title: From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves date: 2020-10-03 pages: extension: .txt txt: ./txt/cord-293333-mqoml9o5.txt cache: ./cache/cord-293333-mqoml9o5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-293333-mqoml9o5.txt' === file2bib.sh === id: cord-294443-w6p3f5qc author: Nadar, Sunil K. title: Managing hypertension during the COVID-19 pandemic date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-294443-w6p3f5qc.txt cache: ./cache/cord-294443-w6p3f5qc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294443-w6p3f5qc.txt' === file2bib.sh === id: cord-294617-i8j36bol author: Dhar, Shabir A title: My fear, my morals: a surgeon’s perspective of the COVID crisis date: 2020-10-14 pages: extension: .txt txt: ./txt/cord-294617-i8j36bol.txt cache: ./cache/cord-294617-i8j36bol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294617-i8j36bol.txt' === file2bib.sh === id: cord-295123-x2gxgave author: Zhou, Wei title: Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia date: 2020-02-21 pages: extension: .txt txt: ./txt/cord-295123-x2gxgave.txt cache: ./cache/cord-295123-x2gxgave.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-295123-x2gxgave.txt' === file2bib.sh === id: cord-292856-7hjzzxtm author: Viasus, Diego title: Influenza A(H1N1)pdm09-related pneumonia and other complications date: 2012-10-31 pages: extension: .txt txt: ./txt/cord-292856-7hjzzxtm.txt cache: ./cache/cord-292856-7hjzzxtm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-292856-7hjzzxtm.txt' === file2bib.sh === id: cord-294073-65h2mkdy author: Ke, Jia title: Strategies and recommendations for the management of gastrointestinal surgery during the COVID-19 pandemic: experience shared by Chinese surgeons date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-294073-65h2mkdy.txt cache: ./cache/cord-294073-65h2mkdy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294073-65h2mkdy.txt' === file2bib.sh === id: cord-294336-fqobpo47 author: Soy, Mehmet title: Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-294336-fqobpo47.txt cache: ./cache/cord-294336-fqobpo47.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-294336-fqobpo47.txt' === file2bib.sh === id: cord-294184-jte9xx5e author: Macleod, Jack title: Surgery during COVID-19 crisis conditions: can we protect our ethical integrity against the odds? date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-294184-jte9xx5e.txt cache: ./cache/cord-294184-jte9xx5e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294184-jte9xx5e.txt' === file2bib.sh === id: cord-293634-4rryqbnu author: Rosen, Kelsey title: Delivering Telerehabilitation to COVID-19 Inpatients:A Retrospective Chart Review Suggests It Is a Viable Option date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-293634-4rryqbnu.txt cache: ./cache/cord-293634-4rryqbnu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293634-4rryqbnu.txt' === file2bib.sh === id: cord-294636-xes8g0x4 author: Brindle, Mary E. title: Approaching Surgical Triage During the COVID-19 Pandemic date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-294636-xes8g0x4.txt cache: ./cache/cord-294636-xes8g0x4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-294636-xes8g0x4.txt' === file2bib.sh === id: cord-293922-knzv4jvj author: Zuo, Y. title: Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-293922-knzv4jvj.txt cache: ./cache/cord-293922-knzv4jvj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-293922-knzv4jvj.txt' === file2bib.sh === id: cord-293704-tnik6sd3 author: Tey, Jeremy title: Navigating the challenges of the COVID-19 outbreak: perspectives from the radiation oncology service in singapore date: 2020-03-31 pages: extension: .txt txt: ./txt/cord-293704-tnik6sd3.txt cache: ./cache/cord-293704-tnik6sd3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293704-tnik6sd3.txt' === file2bib.sh === id: cord-294294-66udu5y4 author: Bullock, Travis S. title: Outpatient surgery in patients with ankle fractures minimises hospital admissions and utilisation of healthcare resources date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-294294-66udu5y4.txt cache: ./cache/cord-294294-66udu5y4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294294-66udu5y4.txt' === file2bib.sh === id: cord-294139-78c5h7la author: Yamakawa, Mai title: Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-294139-78c5h7la.txt cache: ./cache/cord-294139-78c5h7la.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294139-78c5h7la.txt' === file2bib.sh === id: cord-294959-xy8976jz author: Hsu, Elisabeth title: Allium fistulosum congee as a home remedy to ward off the corona virus at an early stage date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-294959-xy8976jz.txt cache: ./cache/cord-294959-xy8976jz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-294959-xy8976jz.txt' === file2bib.sh === id: cord-293740-4c3yemi3 author: Ferrando, Carlos title: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-293740-4c3yemi3.txt cache: ./cache/cord-293740-4c3yemi3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293740-4c3yemi3.txt' === file2bib.sh === id: cord-294371-xot2oj2t author: Citgez, Bulent title: Management of Breast Cancer during the COVID-19 Pandemic date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-294371-xot2oj2t.txt cache: ./cache/cord-294371-xot2oj2t.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294371-xot2oj2t.txt' === file2bib.sh === id: cord-294079-px9c20il author: Chua, Horng-Ruey title: Ensuring Sustainability of Continuous Kidney Replacement Therapy in the Face of Extraordinary Demand: Lessons From the COVID-19 Pandemic date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-294079-px9c20il.txt cache: ./cache/cord-294079-px9c20il.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294079-px9c20il.txt' === file2bib.sh === id: cord-295371-ccqne6nu author: Stoj, Victoria J. title: Dermatology residents and the care of patients with coronavirus disease 2019 (COVID-19) date: 2020-04-04 pages: extension: .txt txt: ./txt/cord-295371-ccqne6nu.txt cache: ./cache/cord-295371-ccqne6nu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-295371-ccqne6nu.txt' === file2bib.sh === id: cord-294064-vdpak3fm author: Iqbal, Muhammad Rafaih title: Single centre concept of ‘cold site’ elective surgery during the peak of COVID-19 pandemic: A cohort study date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-294064-vdpak3fm.txt cache: ./cache/cord-294064-vdpak3fm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294064-vdpak3fm.txt' === file2bib.sh === id: cord-294628-ecg13s7a author: Chia, Ming Li title: Managing COVID-19 in a Novel, Rapidly Deployable Community Isolation Quarantine Facility date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-294628-ecg13s7a.txt cache: ./cache/cord-294628-ecg13s7a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294628-ecg13s7a.txt' === file2bib.sh === id: cord-295323-snrt9odv author: Yadav, Sandeep Kumar title: Creating Backup Management Resources for Spine Care during the Coronavirus Disease 2019 Pandemic date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-295323-snrt9odv.txt cache: ./cache/cord-295323-snrt9odv.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-295323-snrt9odv.txt' === file2bib.sh === id: cord-294907-i836d6im author: Alabdali, Abdullah title: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak at King Abdul-Aziz Medical City-Riyadh from Emergency Medical Services Perspective date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-294907-i836d6im.txt cache: ./cache/cord-294907-i836d6im.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294907-i836d6im.txt' === file2bib.sh === id: cord-294349-ps3qlho2 author: Al-Sharif, Eman title: Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-294349-ps3qlho2.txt cache: ./cache/cord-294349-ps3qlho2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294349-ps3qlho2.txt' === file2bib.sh === id: cord-293852-r72c6584 author: Greco, S. title: Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era date: 2020-10-31 pages: extension: .txt txt: ./txt/cord-293852-r72c6584.txt cache: ./cache/cord-293852-r72c6584.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293852-r72c6584.txt' === file2bib.sh === id: cord-295086-tc3re52f author: Lu, Guoguang title: Dynamic changes in routine blood parameters of a severe COVID-19 case date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-295086-tc3re52f.txt cache: ./cache/cord-295086-tc3re52f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-295086-tc3re52f.txt' === file2bib.sh === id: cord-294270-do6i6ymq author: Banu, Buyukaydin title: Pneumonia date: 2019-11-29 pages: extension: .txt txt: ./txt/cord-294270-do6i6ymq.txt cache: ./cache/cord-294270-do6i6ymq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294270-do6i6ymq.txt' === file2bib.sh === id: cord-295332-wlnss6bg author: AL Shareef, Khaled title: Cytokine Blood Filtration Responses in COVID-19 date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-295332-wlnss6bg.txt cache: ./cache/cord-295332-wlnss6bg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295332-wlnss6bg.txt' === file2bib.sh === id: cord-293547-29i3u83s author: Pfaar, O title: COVID‐19 pandemic: Practical considerations on the organization of an allergy clinic – an EAACI/ARIA Position Paper date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-293547-29i3u83s.txt cache: ./cache/cord-293547-29i3u83s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-293547-29i3u83s.txt' === file2bib.sh === id: cord-294933-oc2glu4a author: Cinesi Gómez, César title: Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-294933-oc2glu4a.txt cache: ./cache/cord-294933-oc2glu4a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294933-oc2glu4a.txt' === file2bib.sh === id: cord-295414-v10454ns author: Baktash, Vadir title: Vitamin D status and outcomes for hospitalised older patients with COVID-19 date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-295414-v10454ns.txt cache: ./cache/cord-295414-v10454ns.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295414-v10454ns.txt' === file2bib.sh === id: cord-295514-vhymj0rw author: Lim, Peter A title: Impact of a viral respiratory epidemic on the practice of medicine and rehabilitation: Severe acute respiratory syndrome date: 2004-08-01 pages: extension: .txt txt: ./txt/cord-295514-vhymj0rw.txt cache: ./cache/cord-295514-vhymj0rw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295514-vhymj0rw.txt' === file2bib.sh === id: cord-296013-6ej3pd0u author: Trinidad, John title: Telemedicine for Inpatient Dermatology Consultations in Response to the COVID-19 Pandemic date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-296013-6ej3pd0u.txt cache: ./cache/cord-296013-6ej3pd0u.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-296013-6ej3pd0u.txt' === file2bib.sh === id: cord-293472-d3iwlpsr author: Afilalo, Marc title: Evaluation and Management of Seasonal Influenza in the Emergency Department date: 2012-04-06 pages: extension: .txt txt: ./txt/cord-293472-d3iwlpsr.txt cache: ./cache/cord-293472-d3iwlpsr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-293472-d3iwlpsr.txt' === file2bib.sh === id: cord-294768-bs6thjw2 author: Alonso-Fernández, Alberto title: Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-294768-bs6thjw2.txt cache: ./cache/cord-294768-bs6thjw2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294768-bs6thjw2.txt' === file2bib.sh === id: cord-294810-mq9vjnro author: Huang, Qiong title: Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-294810-mq9vjnro.txt cache: ./cache/cord-294810-mq9vjnro.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294810-mq9vjnro.txt' === file2bib.sh === id: cord-294527-fct2y5vn author: Guadarrama-Ortiz, Parménides title: Neurological Aspects of SARS-CoV-2 Infection: Mechanisms and Manifestations date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-294527-fct2y5vn.txt cache: ./cache/cord-294527-fct2y5vn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294527-fct2y5vn.txt' === file2bib.sh === id: cord-295800-w0dup04b author: So, Loletta K-Y title: Development of a standard treatment protocol for severe acute respiratory syndrome date: 2003-05-10 pages: extension: .txt txt: ./txt/cord-295800-w0dup04b.txt cache: ./cache/cord-295800-w0dup04b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295800-w0dup04b.txt' === file2bib.sh === id: cord-294969-57xgqf2g author: Green, Bart N. title: Rapid Deployment of Chiropractic Telehealth at 2 Worksite Health Centers in Response to the COVID-19 Pandemic: Observations from the Field date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-294969-57xgqf2g.txt cache: ./cache/cord-294969-57xgqf2g.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294969-57xgqf2g.txt' === file2bib.sh === id: cord-295700-lzaxzuwe author: Shi, Shaobo title: Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-295700-lzaxzuwe.txt cache: ./cache/cord-295700-lzaxzuwe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-295700-lzaxzuwe.txt' === file2bib.sh === id: cord-295798-x7or932x author: Ferrey, Antoney J. title: A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease date: 2020-03-28 pages: extension: .txt txt: ./txt/cord-295798-x7or932x.txt cache: ./cache/cord-295798-x7or932x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295798-x7or932x.txt' === file2bib.sh === id: cord-296113-syi2fwuo author: Peng, Mian title: Two mechanically ventilated cases of COVID-19 successfully managed with a sequential ventilation weaning protocol: Two case reports date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-296113-syi2fwuo.txt cache: ./cache/cord-296113-syi2fwuo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-296113-syi2fwuo.txt' === file2bib.sh === id: cord-295216-eff02z0i author: Ahluwalia, Ranbir title: The impact of imposed delay in elective pediatric neurosurgery: an informed hierarchy of need in the time of mass casualty crisis date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-295216-eff02z0i.txt cache: ./cache/cord-295216-eff02z0i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295216-eff02z0i.txt' === file2bib.sh === id: cord-295971-jtv1jj2z author: Cho, Sun Young title: MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study date: 2016-07-09 pages: extension: .txt txt: ./txt/cord-295971-jtv1jj2z.txt cache: ./cache/cord-295971-jtv1jj2z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295971-jtv1jj2z.txt' === file2bib.sh === id: cord-294593-mh1uh1b3 author: Boloori, Alireza title: Misalignment of Stakeholder Incentives in the Opioid Crisis date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-294593-mh1uh1b3.txt cache: ./cache/cord-294593-mh1uh1b3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-294593-mh1uh1b3.txt' === file2bib.sh === id: cord-294557-4h0sybiy author: Stogiannos, N. title: Coronavirus disease 2019 (COVID-19) in the radiology department: What radiographers need to know date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-294557-4h0sybiy.txt cache: ./cache/cord-294557-4h0sybiy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-294557-4h0sybiy.txt' === file2bib.sh === id: cord-296694-2js639bk author: Price, Laura C title: Thrombosis and COVID-19 pneumonia: the clot thickens! date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-296694-2js639bk.txt cache: ./cache/cord-296694-2js639bk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-296694-2js639bk.txt' === file2bib.sh === id: cord-296018-lgx5k2kp author: Lee, Jong-Bin title: Evaluation of prognosis related to compliance with supportive periodontal treatment in patients with chronic periodontitis: a clinical retrospective study date: 2019-04-17 pages: extension: .txt txt: ./txt/cord-296018-lgx5k2kp.txt cache: ./cache/cord-296018-lgx5k2kp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-296018-lgx5k2kp.txt' === file2bib.sh === id: cord-295794-glcg36si author: Seghers, Victor J. title: After the initial COVID-19 surge: a phased radiology departmental re-opening plan date: 2020-08-22 pages: extension: .txt txt: ./txt/cord-295794-glcg36si.txt cache: ./cache/cord-295794-glcg36si.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-295794-glcg36si.txt' === file2bib.sh === id: cord-294108-uvnh0s9r author: Dube, Taru title: Repurposed Drugs, Molecular Vaccines, Immune‐Modulators, and Nanotherapeutics to Treat and Prevent COVID‐19 Associated with SARS‐CoV‐2, a Deadly Nanovector date: 2020-10-25 pages: extension: .txt txt: ./txt/cord-294108-uvnh0s9r.txt cache: ./cache/cord-294108-uvnh0s9r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294108-uvnh0s9r.txt' === file2bib.sh === id: cord-294788-9usyb1nn author: Baek, Woong Kee title: A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 date: 2020-05-03 pages: extension: .txt txt: ./txt/cord-294788-9usyb1nn.txt cache: ./cache/cord-294788-9usyb1nn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-294788-9usyb1nn.txt' === file2bib.sh === id: cord-297532-ktiwfcop author: De Fata Salvatores, Gaia title: Patients with bullous disorders during COVID‐19 period: management and adherence to treatment date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-297532-ktiwfcop.txt cache: ./cache/cord-297532-ktiwfcop.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-297532-ktiwfcop.txt' === file2bib.sh === id: cord-297208-f4ob3ox6 author: Pisano, Antonio title: Cardiothoracic surgery at the time of COVID-19 pandemic: lessons from the East (and from a previous epidemic) for western battlefields date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-297208-f4ob3ox6.txt cache: ./cache/cord-297208-f4ob3ox6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-297208-f4ob3ox6.txt' === file2bib.sh === id: cord-296605-p67twx7a author: LAU, Arthur Chun-Wing title: Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) date: 2004-03-10 pages: extension: .txt txt: ./txt/cord-296605-p67twx7a.txt cache: ./cache/cord-296605-p67twx7a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-296605-p67twx7a.txt' === file2bib.sh === id: cord-295703-no45mgyd author: ALTAY, O. title: Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date: 2020-10-05 pages: extension: .txt txt: ./txt/cord-295703-no45mgyd.txt cache: ./cache/cord-295703-no45mgyd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295703-no45mgyd.txt' === file2bib.sh === id: cord-296562-3h2oqb9k author: Guillén, Lucía title: Preemptive interleukin-6 blockade in patients with COVID-19 date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-296562-3h2oqb9k.txt cache: ./cache/cord-296562-3h2oqb9k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296562-3h2oqb9k.txt' === file2bib.sh === id: cord-296676-2anl2agl author: Goldberg, Michael F. title: Neuroradiologic manifestations of COVID-19: what the emergency radiologist needs to know date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-296676-2anl2agl.txt cache: ./cache/cord-296676-2anl2agl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296676-2anl2agl.txt' === file2bib.sh === id: cord-296440-18vpg419 author: Beurnier, Antoine title: Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-296440-18vpg419.txt cache: ./cache/cord-296440-18vpg419.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-296440-18vpg419.txt' === file2bib.sh === id: cord-297127-nhgm09db author: Hasseli, Rebecca title: National registry for patients with inflammatory rheumatic diseases (IRD) infected with SARS-CoV-2 in Germany (ReCoVery): a valuable mean to gain rapid and reliable knowledge of the clinical course of SARS-CoV-2 infections in patients with IRD date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-297127-nhgm09db.txt cache: ./cache/cord-297127-nhgm09db.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297127-nhgm09db.txt' === file2bib.sh === id: cord-297836-y9vt6wvu author: Tan, Yi Quan title: Re: Kristian D. Stensland, Todd M. Morgan, Alireza Moinzadeh, et al. Considerations in the Triage of Urologic Surgeries During the COVID-19 Pandemic. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.027: The Forgotten Urological Patient During the COVID-19 Pandemic: Patient Safety Safeguards date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-297836-y9vt6wvu.txt cache: ./cache/cord-297836-y9vt6wvu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-297836-y9vt6wvu.txt' === file2bib.sh === id: cord-296182-hhswage4 author: Meng, Lingzhong title: Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-296182-hhswage4.txt cache: ./cache/cord-296182-hhswage4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-296182-hhswage4.txt' === file2bib.sh === id: cord-297093-ld89vmct author: Clark, Kristina E N title: Safety of intravenous Anakinra in COVID-19 with evidence of hyperinflammation, a case series date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-297093-ld89vmct.txt cache: ./cache/cord-297093-ld89vmct.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297093-ld89vmct.txt' === file2bib.sh === id: cord-296494-6kn4mr04 author: Saban-Ruiz, J. title: COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs. The Role of Aging Beyond Topics date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-296494-6kn4mr04.txt cache: ./cache/cord-296494-6kn4mr04.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-296494-6kn4mr04.txt' === file2bib.sh === id: cord-297414-zq16s9ud author: Koh, Adrian H. C. title: What COVID-19 has taught us: lessons from around the globe date: 2020-06-13 pages: extension: .txt txt: ./txt/cord-297414-zq16s9ud.txt cache: ./cache/cord-297414-zq16s9ud.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297414-zq16s9ud.txt' === file2bib.sh === id: cord-297132-lhfa9fl5 author: Aghagoli, Ghazal title: Neurological Involvement in COVID-19 and Potential Mechanisms: A Review date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-297132-lhfa9fl5.txt cache: ./cache/cord-297132-lhfa9fl5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-297132-lhfa9fl5.txt' === file2bib.sh === id: cord-297832-picpuzvo author: Salazar, Rafael title: Decreased Mortality in Patients With Severe Bronchospasm Associated With SARS-CoV-2: An Alternative to Invasive Mechanical Ventilation date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-297832-picpuzvo.txt cache: ./cache/cord-297832-picpuzvo.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-297832-picpuzvo.txt' === file2bib.sh === id: cord-296331-i4hyzqcv author: Adapa, Sreedhar title: COVID-19 Pandemic Causing Acute Kidney Injury and Impact on Patients With Chronic Kidney Disease and Renal Transplantation date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-296331-i4hyzqcv.txt cache: ./cache/cord-296331-i4hyzqcv.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296331-i4hyzqcv.txt' === file2bib.sh === id: cord-296881-2g81sjnl author: Nabil, Ahmed title: Current coronavirus (SARS-CoV-2) epidemiological, diagnostic and therapeutic approaches: An updated review until June 2020 date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-296881-2g81sjnl.txt cache: ./cache/cord-296881-2g81sjnl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-296881-2g81sjnl.txt' === file2bib.sh === id: cord-298403-ilpzj2sv author: Mintz, Yoav title: Minimally Invasive Surgery is the Key to Patient and Operating room team Safety During the COVID19 Pandemic as well as in the “new normal” or chronic Pandemic State to come date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-298403-ilpzj2sv.txt cache: ./cache/cord-298403-ilpzj2sv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-298403-ilpzj2sv.txt' === file2bib.sh === id: cord-295523-5pv7kw6i author: Picchianti Diamanti, Andrea title: Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-295523-5pv7kw6i.txt cache: ./cache/cord-295523-5pv7kw6i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295523-5pv7kw6i.txt' === file2bib.sh === id: cord-295144-tyyc81uc author: Stradner, Martin H. title: Rheumatic Musculoskeletal Diseases and COVID-19 A Review of the First 6 Months of the Pandemic date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-295144-tyyc81uc.txt cache: ./cache/cord-295144-tyyc81uc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-295144-tyyc81uc.txt' === file2bib.sh === id: cord-289775-40bi87iz author: Haines, David E. title: Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety date: 2014-05-07 pages: extension: .txt txt: ./txt/cord-289775-40bi87iz.txt cache: ./cache/cord-289775-40bi87iz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-289775-40bi87iz.txt' === file2bib.sh === id: cord-009567-osstpum6 author: nan title: Abstracts Oral date: 2008-04-23 pages: extension: .txt txt: ./txt/cord-009567-osstpum6.txt cache: ./cache/cord-009567-osstpum6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-009567-osstpum6.txt' === file2bib.sh === id: cord-296936-5gkx4jxa author: An, M. H. title: Treatment Response to Hydroxychloroquine and Antibiotics for mild to moderate COVID-19: a retrospective cohort study from South Korea date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-296936-5gkx4jxa.txt cache: ./cache/cord-296936-5gkx4jxa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296936-5gkx4jxa.txt' === file2bib.sh === id: cord-296219-zzg9hds0 author: Battaglini, Denise title: Neurological Manifestations of Severe SARS-CoV-2 Infection: Potential Mechanisms and Implications of Individualized Mechanical Ventilation Settings date: 2020-08-12 pages: extension: .txt txt: ./txt/cord-296219-zzg9hds0.txt cache: ./cache/cord-296219-zzg9hds0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296219-zzg9hds0.txt' === file2bib.sh === id: cord-297759-arg71du6 author: Triantafyllou, Tania title: Esophageal cancer: challenges, concerns, and recommendations for management amidst the COVID-19 pandemic date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-297759-arg71du6.txt cache: ./cache/cord-297759-arg71du6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297759-arg71du6.txt' === file2bib.sh === id: cord-298516-0eda4mzs author: Fadlallah, Ali title: LASIK procedures during COVID-19 date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-298516-0eda4mzs.txt cache: ./cache/cord-298516-0eda4mzs.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-298516-0eda4mzs.txt' === file2bib.sh === id: cord-298034-0ntxm28a author: Tepper, Joel E. title: Ethical Issues in Radiation Oncology During a Pandemic date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-298034-0ntxm28a.txt cache: ./cache/cord-298034-0ntxm28a.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-298034-0ntxm28a.txt' === file2bib.sh === id: cord-297506-1xjgsz4y author: Jansen, Jaclyn H. title: A novel presentation of COVID-19 via community acquired infection date: 2020-03-31 pages: extension: .txt txt: ./txt/cord-297506-1xjgsz4y.txt cache: ./cache/cord-297506-1xjgsz4y.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-297506-1xjgsz4y.txt' === file2bib.sh === id: cord-296588-q2716lda author: Hanson, Kimberly E title: Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19 date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-296588-q2716lda.txt cache: ./cache/cord-296588-q2716lda.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296588-q2716lda.txt' === file2bib.sh === id: cord-297638-ab70s980 author: Stephens, Angela J. title: General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-297638-ab70s980.txt cache: ./cache/cord-297638-ab70s980.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-297638-ab70s980.txt' === file2bib.sh === id: cord-299024-jkqdzt87 author: Mangner, Norman title: Paraneoplastic syndrome and SARS-CoV-2 – incremental effect of two thrombogenic conditions? date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-299024-jkqdzt87.txt cache: ./cache/cord-299024-jkqdzt87.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299024-jkqdzt87.txt' === file2bib.sh === id: cord-026031-hnf5vayd author: Ford, Richard B. title: Emergency Care date: 2009-05-21 pages: extension: .txt txt: ./txt/cord-026031-hnf5vayd.txt cache: ./cache/cord-026031-hnf5vayd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-026031-hnf5vayd.txt' === file2bib.sh === id: cord-298967-vjyh1xvh author: Bertossi, Dario title: Safety guidelines for non‐surgical facial procedures during covid‐19 outbreak date: 2020-06-07 pages: extension: .txt txt: ./txt/cord-298967-vjyh1xvh.txt cache: ./cache/cord-298967-vjyh1xvh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-298967-vjyh1xvh.txt' === file2bib.sh === id: cord-297494-6yxmaihl author: Katsurada, Naoko title: The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study date: 2017-12-06 pages: extension: .txt txt: ./txt/cord-297494-6yxmaihl.txt cache: ./cache/cord-297494-6yxmaihl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297494-6yxmaihl.txt' === file2bib.sh === id: cord-297425-vcqqssm8 author: Aries, James A. title: Clinical Outcome of Coronavirus Disease 2019 in Haemato‐oncology Patients date: 2020-05-18 pages: extension: .txt txt: ./txt/cord-297425-vcqqssm8.txt cache: ./cache/cord-297425-vcqqssm8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297425-vcqqssm8.txt' === file2bib.sh === id: cord-298067-awo3smgp author: Li, Huanjie title: Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-298067-awo3smgp.txt cache: ./cache/cord-298067-awo3smgp.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-298067-awo3smgp.txt' === file2bib.sh === id: cord-296773-5o4hr6ir author: Zeneli, A. title: Mitigating strategies and nursing response for cancer care management during the COVID‐19 pandemic: an Italian experience date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-296773-5o4hr6ir.txt cache: ./cache/cord-296773-5o4hr6ir.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-296773-5o4hr6ir.txt' === file2bib.sh === id: cord-297327-19dfgfz6 author: Drożdżal, Sylwester title: COVID-19: Pain Management in Patients with SARS-CoV-2 Infection—Molecular Mechanisms, Challenges, and Perspectives date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-297327-19dfgfz6.txt cache: ./cache/cord-297327-19dfgfz6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-297327-19dfgfz6.txt' === file2bib.sh === id: cord-296607-h2zwlyz7 author: Watson, Ryan A. title: Anti-coagulant and anti-platelet therapy in the COVID-19 patient: a best practices quality initiative across a large health system date: 2020-06-09 pages: extension: .txt txt: ./txt/cord-296607-h2zwlyz7.txt cache: ./cache/cord-296607-h2zwlyz7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-296607-h2zwlyz7.txt' === file2bib.sh === id: cord-297138-t8b3914h author: Duijker, G. title: Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection: Results from a double-blind randomized controlled trial date: 2015-04-02 pages: extension: .txt txt: ./txt/cord-297138-t8b3914h.txt cache: ./cache/cord-297138-t8b3914h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297138-t8b3914h.txt' === file2bib.sh === id: cord-022650-phsr10jp author: nan title: Abstracts TPS date: 2018-08-14 pages: extension: .txt txt: ./txt/cord-022650-phsr10jp.txt cache: ./cache/cord-022650-phsr10jp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-022650-phsr10jp.txt' === file2bib.sh === id: cord-298325-2gm4fnqi author: Shah, Sonia title: Novel use of home pulse oximetry monitoring in COVID‐19 patients discharged from the emergency department identifies need for hospitalization date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-298325-2gm4fnqi.txt cache: ./cache/cord-298325-2gm4fnqi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-298325-2gm4fnqi.txt' === file2bib.sh === id: cord-297001-4g3wb8qi author: Tal, Shir title: Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-297001-4g3wb8qi.txt cache: ./cache/cord-297001-4g3wb8qi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297001-4g3wb8qi.txt' === file2bib.sh === id: cord-299681-smhto9em author: Elsaie, Mohamed L. title: Herpes zoster might be an indicator for Latent COVID 19 infection date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-299681-smhto9em.txt cache: ./cache/cord-299681-smhto9em.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299681-smhto9em.txt' === file2bib.sh === id: cord-299489-6v225vte author: Gómez-Hernández, María Teresa title: TWICE LUCKY: ELDERLY PATIENT SURVIVING BOTH COVID-19 AND SERENDIPITOUS LUNG CARCINOMA date: 2020-07-25 pages: extension: .txt txt: ./txt/cord-299489-6v225vte.txt cache: ./cache/cord-299489-6v225vte.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-299489-6v225vte.txt' === file2bib.sh === id: cord-297518-6y2uzcde author: Leulseged, T. W. title: Determinants of Developing Symptomatic Disease in Ethiopian COVID-19 Patients date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-297518-6y2uzcde.txt cache: ./cache/cord-297518-6y2uzcde.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-297518-6y2uzcde.txt' === file2bib.sh === id: cord-294700-pb5k21da author: Dulek, Daniel E title: Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute COVID-19 in Pediatric Patients date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-294700-pb5k21da.txt cache: ./cache/cord-294700-pb5k21da.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-294700-pb5k21da.txt' === file2bib.sh === id: cord-298056-svwtfshi author: Fabio, Ciceri title: Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-298056-svwtfshi.txt cache: ./cache/cord-298056-svwtfshi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-298056-svwtfshi.txt' === file2bib.sh === id: cord-298094-ctikhqvr author: Elias, Pierre title: The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19 date: 2020-08-15 pages: extension: .txt txt: ./txt/cord-298094-ctikhqvr.txt cache: ./cache/cord-298094-ctikhqvr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-298094-ctikhqvr.txt' === file2bib.sh === id: cord-299222-vmofcrim author: Rivas‐Pollmar, María Isabel title: Thromboprophylaxis in a patient with COVID‐19 and severe hemophilia A on emicizumab prophylaxis date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-299222-vmofcrim.txt cache: ./cache/cord-299222-vmofcrim.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299222-vmofcrim.txt' === file2bib.sh === id: cord-298679-w0yp4u19 author: Iftimie, Simona title: Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-298679-w0yp4u19.txt cache: ./cache/cord-298679-w0yp4u19.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-298679-w0yp4u19.txt' === file2bib.sh === id: cord-300038-1fjb6b8e author: Cantini, Fabrizio title: Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact date: 2020-04-23 pages: extension: .txt txt: ./txt/cord-300038-1fjb6b8e.txt cache: ./cache/cord-300038-1fjb6b8e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300038-1fjb6b8e.txt' === file2bib.sh === id: cord-298787-4vo9gpiu author: Frost, Holly M. title: Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1–3 date: 2013-10-16 pages: extension: .txt txt: ./txt/cord-298787-4vo9gpiu.txt cache: ./cache/cord-298787-4vo9gpiu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-298787-4vo9gpiu.txt' === file2bib.sh === id: cord-299124-g70v4crs author: Lancaster, Elizabeth M. title: Impact of the COVID-19 pandemic on an academic vascular practice and a multi-disciplinary limb preservation program date: 2020-09-12 pages: extension: .txt txt: ./txt/cord-299124-g70v4crs.txt cache: ./cache/cord-299124-g70v4crs.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-299124-g70v4crs.txt' === file2bib.sh === id: cord-299570-1xz5r95f author: Martínez-García, M title: Telemedicina con telemonitorización en el seguimiento de pacientes con COVID-19 date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-299570-1xz5r95f.txt cache: ./cache/cord-299570-1xz5r95f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-299570-1xz5r95f.txt' === file2bib.sh === id: cord-298894-t5hyfum3 author: Rifino, Nicola title: Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy date: 2020-10-07 pages: extension: .txt txt: ./txt/cord-298894-t5hyfum3.txt cache: ./cache/cord-298894-t5hyfum3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-298894-t5hyfum3.txt' === file2bib.sh === id: cord-300995-tqz2bkdo author: Tagliaferri, Luca title: Skin cancer triage and management during COVID‐19 pandemic date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-300995-tqz2bkdo.txt cache: ./cache/cord-300995-tqz2bkdo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-300995-tqz2bkdo.txt' === file2bib.sh === id: cord-299835-92karhpl author: Ho, Khek Y. title: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore date: 2004-02-17 pages: extension: .txt txt: ./txt/cord-299835-92karhpl.txt cache: ./cache/cord-299835-92karhpl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299835-92karhpl.txt' === file2bib.sh === id: cord-297870-m7n43k4p author: Azevedo, Rafael Bellotti title: Covid-19 and the cardiovascular system: a comprehensive review date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-297870-m7n43k4p.txt cache: ./cache/cord-297870-m7n43k4p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-297870-m7n43k4p.txt' === file2bib.sh === id: cord-299881-weptfpa2 author: Halvachizadeh, Sascha title: The impact of SARS-CoV-2 (COVID-19) pandemic on trauma bay management and guideline adherence in a European level-one-trauma centre date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-299881-weptfpa2.txt cache: ./cache/cord-299881-weptfpa2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299881-weptfpa2.txt' === file2bib.sh === id: cord-299784-xxxdjfbc author: Bettari, Luca title: Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-299784-xxxdjfbc.txt cache: ./cache/cord-299784-xxxdjfbc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-299784-xxxdjfbc.txt' === file2bib.sh === id: cord-299621-m4kdkmey author: Kumar, A. title: Outbreak of Middle East respiratory syndrome coronavirus, Saudi Arabian experience date: 2017-08-31 pages: extension: .txt txt: ./txt/cord-299621-m4kdkmey.txt cache: ./cache/cord-299621-m4kdkmey.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299621-m4kdkmey.txt' === file2bib.sh === id: cord-298974-69xjc5yq author: Adegboye, Oyelola A. title: Network Analysis of MERS Coronavirus within Households, Communities, and Hospitals to Identify Most Centralized and Super-Spreading in the Arabian Peninsula, 2012 to 2016 date: 2018-05-07 pages: extension: .txt txt: ./txt/cord-298974-69xjc5yq.txt cache: ./cache/cord-298974-69xjc5yq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-298974-69xjc5yq.txt' === file2bib.sh === id: cord-299082-s8bm40vy author: Wang, Yueying title: Cardiac arrhythmias in patients with COVID‐19 date: 2020-07-26 pages: extension: .txt txt: ./txt/cord-299082-s8bm40vy.txt cache: ./cache/cord-299082-s8bm40vy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-299082-s8bm40vy.txt' === file2bib.sh === id: cord-299679-6z9e5gi6 author: Rello, Jordi title: Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-299679-6z9e5gi6.txt cache: ./cache/cord-299679-6z9e5gi6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299679-6z9e5gi6.txt' === file2bib.sh === id: cord-299156-1dwsm3ie author: Shemer, Asaf title: Ocular involvement in coronavirus disease 2019 (COVID-19): a clinical and molecular analysis date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-299156-1dwsm3ie.txt cache: ./cache/cord-299156-1dwsm3ie.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299156-1dwsm3ie.txt' === file2bib.sh === id: cord-299449-226dd23u author: Bernhardt, Denise title: Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas date: 2020-05-05 pages: extension: .txt txt: ./txt/cord-299449-226dd23u.txt cache: ./cache/cord-299449-226dd23u.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299449-226dd23u.txt' === file2bib.sh === id: cord-299333-qu0bmov5 author: Reddy, Gireesh B. title: Clinical Characteristics and Multisystem Imaging Findings of COVID-19: An Overview for Orthopedic Surgeons date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-299333-qu0bmov5.txt cache: ./cache/cord-299333-qu0bmov5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-299333-qu0bmov5.txt' === file2bib.sh === id: cord-300044-vn4c6wh7 author: Kim, Ji Won title: From White Count to White Out() date: 2015-08-05 pages: extension: .txt txt: ./txt/cord-300044-vn4c6wh7.txt cache: ./cache/cord-300044-vn4c6wh7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300044-vn4c6wh7.txt' === file2bib.sh === id: cord-299254-kqpnwkg5 author: Sun, Yingcheng title: INSMA: An integrated system for multimodal data acquisition and analysis in the intensive care unit date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-299254-kqpnwkg5.txt cache: ./cache/cord-299254-kqpnwkg5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-299254-kqpnwkg5.txt' === file2bib.sh === id: cord-300458-jeuwaj50 author: Maisch, Bernhard title: COVID-19—What we know and what we need to know: There are more questions than answers date: 2020-04-23 pages: extension: .txt txt: ./txt/cord-300458-jeuwaj50.txt cache: ./cache/cord-300458-jeuwaj50.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-300458-jeuwaj50.txt' === file2bib.sh === id: cord-300510-fhpkdqr0 author: Mojoli, Francesco title: Our recommendations for acute management of COVID-19 date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-300510-fhpkdqr0.txt cache: ./cache/cord-300510-fhpkdqr0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300510-fhpkdqr0.txt' === file2bib.sh === id: cord-300697-p96i25uc author: Chen, Taojiang title: A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report date: 2020-09-29 pages: extension: .txt txt: ./txt/cord-300697-p96i25uc.txt cache: ./cache/cord-300697-p96i25uc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300697-p96i25uc.txt' === file2bib.sh === id: cord-300344-57vxlctl author: Roof, Kevin S. title: Virtual On Treatment Visits: Implementation, Patient Perspectives, Barriers, Limitations, Benefits and Opportunities. date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-300344-57vxlctl.txt cache: ./cache/cord-300344-57vxlctl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300344-57vxlctl.txt' === file2bib.sh === id: cord-301146-no9pw4gn author: Lattenist, R. title: COVID-19 in Adult Patients with Hematological Disease: Analysis of Clinical Characteristics and Outcomes date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-301146-no9pw4gn.txt cache: ./cache/cord-301146-no9pw4gn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-301146-no9pw4gn.txt' === file2bib.sh === id: cord-301148-duttw9xn author: Golestanieraghi, Majid title: Early application of prone position for management of Covid-19 patients date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-301148-duttw9xn.txt cache: ./cache/cord-301148-duttw9xn.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-301148-duttw9xn.txt' === file2bib.sh === id: cord-299750-zkrlm3ds author: Cui, Wei title: Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China date: 2010-05-31 pages: extension: .txt txt: ./txt/cord-299750-zkrlm3ds.txt cache: ./cache/cord-299750-zkrlm3ds.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-299750-zkrlm3ds.txt' === file2bib.sh === id: cord-301281-yur5hs2h author: Zelek, Wioleta M. title: Complement Inhibition with the C5 Blocker LFG316 in Severe COVID-19 date: 2020-11-01 pages: extension: .txt txt: ./txt/cord-301281-yur5hs2h.txt cache: ./cache/cord-301281-yur5hs2h.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-301281-yur5hs2h.txt' === file2bib.sh === id: cord-301579-q23nhmgs author: Tabaza, Luai title: Robotic‐assisted percutaneous coronary intervention in a COVID‐19 patient date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-301579-q23nhmgs.txt cache: ./cache/cord-301579-q23nhmgs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-301579-q23nhmgs.txt' === file2bib.sh === id: cord-301087-9vl5pqi7 author: Teh, Benjamin W. title: Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital date: 2014-12-10 pages: extension: .txt txt: ./txt/cord-301087-9vl5pqi7.txt cache: ./cache/cord-301087-9vl5pqi7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-301087-9vl5pqi7.txt' === file2bib.sh === id: cord-301011-xbuqd0j5 author: Felten-Barentsz, Karin M title: Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19 date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-301011-xbuqd0j5.txt cache: ./cache/cord-301011-xbuqd0j5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-301011-xbuqd0j5.txt' === file2bib.sh === id: cord-300811-l4y7df2f author: Aggarwal, Gaurav title: Association of Cardiovascular Disease with Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-300811-l4y7df2f.txt cache: ./cache/cord-300811-l4y7df2f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300811-l4y7df2f.txt' === file2bib.sh === id: cord-301521-mpm43aga author: Teixeira, Andre Luiz Schuh title: La urgencia de implementar y ampliar la telepsiquiatría durante la crisis de COVID-19: perspectiva de los psiquiatras que inician su carrera date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-301521-mpm43aga.txt cache: ./cache/cord-301521-mpm43aga.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-301521-mpm43aga.txt' === file2bib.sh === id: cord-301079-n1nytr6k author: Tan, Li title: Air and surface contamination by SARS-CoV-2 virus in a tertiary hospital in Wuhan, China date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-301079-n1nytr6k.txt cache: ./cache/cord-301079-n1nytr6k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-301079-n1nytr6k.txt' === file2bib.sh === id: cord-301832-6czrdmzb author: Leber, Danielle title: PC-FACS September 1, 2020 date: 2020-09-06 pages: extension: .txt txt: ./txt/cord-301832-6czrdmzb.txt cache: ./cache/cord-301832-6czrdmzb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-301832-6czrdmzb.txt' === file2bib.sh === id: cord-301340-lhh04pum author: Jamieson, Frances B. title: Human Torovirus: A New Nosocomial Gastrointestinal Pathogen date: 1998-11-17 pages: extension: .txt txt: ./txt/cord-301340-lhh04pum.txt cache: ./cache/cord-301340-lhh04pum.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-301340-lhh04pum.txt' === file2bib.sh === id: cord-302062-wqmynngg author: Sierra-Hidalgo, Fernando title: Large artery ischemic stroke in severe COVID-19 date: 2020-06-27 pages: extension: .txt txt: ./txt/cord-302062-wqmynngg.txt cache: ./cache/cord-302062-wqmynngg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302062-wqmynngg.txt' === file2bib.sh === id: cord-300866-cso6l6ze author: Bao, Yi title: Clinical Features of COVID-19 in a Young Man with Massive Cerebral Hemorrhage—Case Report date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-300866-cso6l6ze.txt cache: ./cache/cord-300866-cso6l6ze.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300866-cso6l6ze.txt' === file2bib.sh === id: cord-300183-z3fwtwqb author: Ahmed, Taha title: Community and healthcare system-related factors feeding the phenomenon of evading medical attention for time-dependent emergencies during COVID-19 crisis date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-300183-z3fwtwqb.txt cache: ./cache/cord-300183-z3fwtwqb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-300183-z3fwtwqb.txt' === file2bib.sh === id: cord-299346-f13xly6q author: Awad, Mohamed E. title: Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed Coronavirus Disease 2019 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current Coronavirus Disease 2019 Pandemic date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-299346-f13xly6q.txt cache: ./cache/cord-299346-f13xly6q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-299346-f13xly6q.txt' === file2bib.sh === id: cord-300774-5mrkmctl author: Hernández-Mora, Miguel Górgolas title: Compassionate Use of Tocilizumab in Severe SARS-CoV2 Pneumonia date: 2020-10-25 pages: extension: .txt txt: ./txt/cord-300774-5mrkmctl.txt cache: ./cache/cord-300774-5mrkmctl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-300774-5mrkmctl.txt' === file2bib.sh === id: cord-302244-uwicyuhk author: Hoilat, Gilles J title: Percutaneous Mechanical Pulmonary Thrombectomy in a Patient With Pulmonary Embolism as a First Presentation of COVID-19 date: 2020-08-01 pages: extension: .txt txt: ./txt/cord-302244-uwicyuhk.txt cache: ./cache/cord-302244-uwicyuhk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302244-uwicyuhk.txt' === file2bib.sh === id: cord-301590-70qmpccs author: Campos, António title: The Paradigm Shift of Ophthalmology in the COVID-19 Era date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-301590-70qmpccs.txt cache: ./cache/cord-301590-70qmpccs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-301590-70qmpccs.txt' === file2bib.sh === id: cord-300559-vuuxthx2 author: Deng, Ming title: Obesity as a Potential Predictor of Disease Severity in Young COVID‐19 Patients: A Retrospective Study date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-300559-vuuxthx2.txt cache: ./cache/cord-300559-vuuxthx2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300559-vuuxthx2.txt' === file2bib.sh === id: cord-300356-oorac5he author: Nair, Girish B. title: Community-Acquired Pneumonia: An Unfinished Battle date: 2011-10-05 pages: extension: .txt txt: ./txt/cord-300356-oorac5he.txt cache: ./cache/cord-300356-oorac5he.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-300356-oorac5he.txt' === file2bib.sh === id: cord-301592-n5ns3m34 author: Ivaska, Lauri title: Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection date: 2017-01-07 pages: extension: .txt txt: ./txt/cord-301592-n5ns3m34.txt cache: ./cache/cord-301592-n5ns3m34.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-301592-n5ns3m34.txt' === file2bib.sh === id: cord-301391-5dvf1mi0 author: Islam, Md. Milon title: Breathing Aid Devices to Support Novel Coronavirus (COVID-19)Infected Patients date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-301391-5dvf1mi0.txt cache: ./cache/cord-301391-5dvf1mi0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-301391-5dvf1mi0.txt' === file2bib.sh === id: cord-300608-eju7wnb9 author: Sheervalilou, Roghayeh title: COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-300608-eju7wnb9.txt cache: ./cache/cord-300608-eju7wnb9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300608-eju7wnb9.txt' === file2bib.sh === id: cord-301947-b6nwaost author: Millán-Oñate, José title: Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-301947-b6nwaost.txt cache: ./cache/cord-301947-b6nwaost.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-301947-b6nwaost.txt' === file2bib.sh === id: cord-301779-y07xjnpe author: Fox, Sharon E title: Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-301779-y07xjnpe.txt cache: ./cache/cord-301779-y07xjnpe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-301779-y07xjnpe.txt' === file2bib.sh === id: cord-301805-sb0ij8k7 author: Fuentes, Blanca title: Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-301805-sb0ij8k7.txt cache: ./cache/cord-301805-sb0ij8k7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-301805-sb0ij8k7.txt' === file2bib.sh === id: cord-302389-h7jm1etb author: Moazenzadeh, Mansoor title: First reported case of unrepaired tetralogy of Fallot complicated with coronavirus disease-19 (COVID-19) date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-302389-h7jm1etb.txt cache: ./cache/cord-302389-h7jm1etb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-302389-h7jm1etb.txt' === file2bib.sh === id: cord-300303-d4qmtysd author: de Azambuja, Evandro title: ESMO Management and treatment adapted recommendations in the COVID-19 era: Breast Cancer date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-300303-d4qmtysd.txt cache: ./cache/cord-300303-d4qmtysd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-300303-d4qmtysd.txt' === file2bib.sh === id: cord-301342-ikvpkhfp author: Xue, Katherine S title: Parallel evolution of influenza across multiple spatiotemporal scales date: 2017-06-27 pages: extension: .txt txt: ./txt/cord-301342-ikvpkhfp.txt cache: ./cache/cord-301342-ikvpkhfp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-301342-ikvpkhfp.txt' === file2bib.sh === id: cord-297840-z5l6vdsr author: Río, Francisco García title: Air Travel and Respiratory Disease date: 2007-02-28 pages: extension: .txt txt: ./txt/cord-297840-z5l6vdsr.txt cache: ./cache/cord-297840-z5l6vdsr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-297840-z5l6vdsr.txt' === file2bib.sh === id: cord-301402-andxwyi3 author: Ding, Benjamin Tze Keong title: Operating in a Pandemic: Lessons and Strategies from an Orthopaedic Unit at the Epicenter of COVID-19 in Singapore date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-301402-andxwyi3.txt cache: ./cache/cord-301402-andxwyi3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-301402-andxwyi3.txt' === file2bib.sh === id: cord-302115-r39ser2c author: Matricardi, Paolo Maria title: The first, holistic immunological model of COVID‐19: implications for prevention, diagnosis, and public health measures date: 2020-05-02 pages: extension: .txt txt: ./txt/cord-302115-r39ser2c.txt cache: ./cache/cord-302115-r39ser2c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302115-r39ser2c.txt' === file2bib.sh === id: cord-301992-oin1m0uq author: Ferreira, Cristine Homsi Jorge title: A guide to physiotherapy in urogynecology for patient care during the COVID-19 pandemic date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-301992-oin1m0uq.txt cache: ./cache/cord-301992-oin1m0uq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-301992-oin1m0uq.txt' === file2bib.sh === id: cord-301811-ykpiorgo author: Tanaka, Takuma title: Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing date: 2020-10-28 pages: extension: .txt txt: ./txt/cord-301811-ykpiorgo.txt cache: ./cache/cord-301811-ykpiorgo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-301811-ykpiorgo.txt' === file2bib.sh === id: cord-300445-qzu4gz2d author: Zhang, Xiao-lei title: Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-300445-qzu4gz2d.txt cache: ./cache/cord-300445-qzu4gz2d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-300445-qzu4gz2d.txt' === file2bib.sh === id: cord-302448-2r4rtixg author: Kharma, Nadir title: Anticoagulation in critically ill patients on mechanical ventilation suffering from COVID-19 disease, The ANTI-CO trial: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-07 pages: extension: .txt txt: ./txt/cord-302448-2r4rtixg.txt cache: ./cache/cord-302448-2r4rtixg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302448-2r4rtixg.txt' === file2bib.sh === id: cord-301800-ssdzd43t author: Atal, Shubham title: Approval of Itolizumab for COVID-19: A Premature Decision or Need of The Hour? date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-301800-ssdzd43t.txt cache: ./cache/cord-301800-ssdzd43t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-301800-ssdzd43t.txt' === file2bib.sh === id: cord-302684-r4ger87o author: Whisenant, Jennifer G. title: TERAVOLT: Thoracic Cancers International COVID-19 Collaboration date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-302684-r4ger87o.txt cache: ./cache/cord-302684-r4ger87o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302684-r4ger87o.txt' === file2bib.sh === id: cord-302215-sqrbj5r4 author: Vanden Eynde, Jean Jacques title: COVID-19: An Update about the Discovery Clinical Trial date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-302215-sqrbj5r4.txt cache: ./cache/cord-302215-sqrbj5r4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-302215-sqrbj5r4.txt' === file2bib.sh === id: cord-292094-vmsdhccp author: Mandell, Lionel A. title: Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults date: 2007-03-01 pages: extension: .txt txt: ./txt/cord-292094-vmsdhccp.txt cache: ./cache/cord-292094-vmsdhccp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-292094-vmsdhccp.txt' === file2bib.sh === id: cord-302788-kg8zwysg author: Conrad, Rachel C. title: Duties toward Patients with Psychiatric Illness date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-302788-kg8zwysg.txt cache: ./cache/cord-302788-kg8zwysg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-302788-kg8zwysg.txt' === file2bib.sh === id: cord-302226-0rhgmtbo author: Bajpai, Vijeta title: Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit date: 2019 pages: extension: .txt txt: ./txt/cord-302226-0rhgmtbo.txt cache: ./cache/cord-302226-0rhgmtbo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302226-0rhgmtbo.txt' === file2bib.sh === id: cord-302413-7a80jff2 author: Brown, Timothy S. title: The Effect of The COVID-19 Pandemic On Electively Scheduled HIP and KNEE Arthroplasty Patients in THE United States date: 2020-04-22 pages: extension: .txt txt: ./txt/cord-302413-7a80jff2.txt cache: ./cache/cord-302413-7a80jff2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302413-7a80jff2.txt' === file2bib.sh === id: cord-302667-ei151qpd author: Sekar, Raghul title: Challenges Faced by an Otolaryngology Resident During Covid-19 Pandemic: An Indian Perspective date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-302667-ei151qpd.txt cache: ./cache/cord-302667-ei151qpd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302667-ei151qpd.txt' === file2bib.sh === id: cord-300963-1n1f8mf2 author: Gajendran, Mahesh title: Inflammatory bowel disease amid the COVID-19 pandemic: impact, management strategies, and lessons learned date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-300963-1n1f8mf2.txt cache: ./cache/cord-300963-1n1f8mf2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300963-1n1f8mf2.txt' === file2bib.sh === id: cord-023346-8sqbqjm1 author: nan title: MONDAY: POSTERS date: 2005-06-08 pages: extension: .txt txt: ./txt/cord-023346-8sqbqjm1.txt cache: ./cache/cord-023346-8sqbqjm1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 23 resourceName b'cord-023346-8sqbqjm1.txt' === file2bib.sh === id: cord-300080-l0fyxtva author: Venkat, Arvind title: Ethical Issues in the Response to Ebola Virus Disease in US Emergency Departments: A Position Paper of the American College of Emergency Physicians, the Emergency Nurses Association and the Society for Academic Emergency Medicine date: 2015-03-10 pages: extension: .txt txt: ./txt/cord-300080-l0fyxtva.txt cache: ./cache/cord-300080-l0fyxtva.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-300080-l0fyxtva.txt' === file2bib.sh === id: cord-303460-abutfxtf author: Searle, Tamara title: Screen rhytides: the cosmetic legacy of COVID‐19 date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-303460-abutfxtf.txt cache: ./cache/cord-303460-abutfxtf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303460-abutfxtf.txt' === file2bib.sh === id: cord-302177-8w3ojgd4 author: Cavayas, Yiorgos Alexandros title: Early experience with critically ill patients with COVID-19 in Montreal date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-302177-8w3ojgd4.txt cache: ./cache/cord-302177-8w3ojgd4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-302177-8w3ojgd4.txt' === file2bib.sh === id: cord-302864-2xnq1oq7 author: Quartuccio, Luca title: Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-302864-2xnq1oq7.txt cache: ./cache/cord-302864-2xnq1oq7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302864-2xnq1oq7.txt' === file2bib.sh === id: cord-302756-343y63e5 author: Thachil, J title: Understanding the COVID‐19 coagulopathy spectrum date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-302756-343y63e5.txt cache: ./cache/cord-302756-343y63e5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302756-343y63e5.txt' === file2bib.sh === id: cord-302862-znnlyz3y author: Lim, Peter A.C. title: Transverse Myelitis date: 2019-04-17 pages: extension: .txt txt: ./txt/cord-302862-znnlyz3y.txt cache: ./cache/cord-302862-znnlyz3y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302862-znnlyz3y.txt' === file2bib.sh === id: cord-303065-dyg2baog author: Williams, Michael title: Patient-Centered Surgical Care Meets the Social Determinants of Health date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-303065-dyg2baog.txt cache: ./cache/cord-303065-dyg2baog.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303065-dyg2baog.txt' === file2bib.sh === id: cord-303192-il3s8lgp author: Tam, Lai‐Shan title: Care for patients with rheumatic diseases during COVID‐19 pandemic: A position statement from APLAR date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-303192-il3s8lgp.txt cache: ./cache/cord-303192-il3s8lgp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303192-il3s8lgp.txt' === file2bib.sh === id: cord-302695-vyo3w2a4 author: Albertini, Laetitia title: Observational study on off-label use of tocilizumab in patients with severe COVID-19 date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-302695-vyo3w2a4.txt cache: ./cache/cord-302695-vyo3w2a4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-302695-vyo3w2a4.txt' === file2bib.sh === id: cord-303145-rc5luali author: Banach, Maciej title: Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-303145-rc5luali.txt cache: ./cache/cord-303145-rc5luali.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303145-rc5luali.txt' === file2bib.sh === id: cord-302316-raf5rlkq author: Brüssow, Harald title: COVID‐19: From pathogenesis models to the first drug trials date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-302316-raf5rlkq.txt cache: ./cache/cord-302316-raf5rlkq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302316-raf5rlkq.txt' === file2bib.sh === id: cord-303349-0kn7apl3 author: Lippi, Giuseppe title: Hemoglobin value may be decreased in patients with severe coronavirus disease 2019 date: 2020-04-02 pages: extension: .txt txt: ./txt/cord-303349-0kn7apl3.txt cache: ./cache/cord-303349-0kn7apl3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303349-0kn7apl3.txt' === file2bib.sh === id: cord-302806-1e99cygs author: Bozkurt, Banu title: The COVID-19 Pandemic: Clinical Information for Ophthalmologists date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-302806-1e99cygs.txt cache: ./cache/cord-302806-1e99cygs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302806-1e99cygs.txt' === file2bib.sh === id: cord-303244-5tfrmsm7 author: Kugasia, Irfanali R. title: Amiodarone Toxicity Presenting with Acute Onset of Systemic Inflammatory Response Syndrome and Multiorgan Failure Mimicking Sepsis date: 2020-10-23 pages: extension: .txt txt: ./txt/cord-303244-5tfrmsm7.txt cache: ./cache/cord-303244-5tfrmsm7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303244-5tfrmsm7.txt' === file2bib.sh === id: cord-302459-grs2x26l author: Matin, Farhana title: A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer date: 2018-04-27 pages: extension: .txt txt: ./txt/cord-302459-grs2x26l.txt cache: ./cache/cord-302459-grs2x26l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-302459-grs2x26l.txt' === file2bib.sh === id: cord-302997-39o08tt1 author: Ceruti, S. title: Reduced mortality and shorten ICU stay in SARS-COV-2 pneumonia: a low PEEP strategy date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-302997-39o08tt1.txt cache: ./cache/cord-302997-39o08tt1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-302997-39o08tt1.txt' === file2bib.sh === id: cord-303017-4zx94rm6 author: Barbieri, Antonio title: Can Beta-2-Adrenergic Pathway Be a New Target to Combat SARS-CoV-2 Hyperinflammatory Syndrome?—Lessons Learned From Cancer date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-303017-4zx94rm6.txt cache: ./cache/cord-303017-4zx94rm6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-303017-4zx94rm6.txt' === file2bib.sh === id: cord-302800-852w35od author: Liu, Xuebing title: Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China date: 2020-04-19 pages: extension: .txt txt: ./txt/cord-302800-852w35od.txt cache: ./cache/cord-302800-852w35od.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302800-852w35od.txt' === file2bib.sh === id: cord-303600-96vtj89w author: Kapoor, Deeksha title: Elective Gastrointestinal Surgery in COVID Times date: 2020-10-22 pages: extension: .txt txt: ./txt/cord-303600-96vtj89w.txt cache: ./cache/cord-303600-96vtj89w.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303600-96vtj89w.txt' === file2bib.sh === id: cord-302576-fv2ib5vc author: Barisione, Emanuela title: Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-302576-fv2ib5vc.txt cache: ./cache/cord-302576-fv2ib5vc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-302576-fv2ib5vc.txt' === file2bib.sh === id: cord-302821-b9ikg0xy author: Gawałko, Monika title: COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-302821-b9ikg0xy.txt cache: ./cache/cord-302821-b9ikg0xy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-302821-b9ikg0xy.txt' === file2bib.sh === id: cord-303363-uu9hb1c9 author: Karimi, Mehran title: Implications of SARSr-CoV 2 infection in thalassemias: Do patients fall into the “high clinical risk” category? date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-303363-uu9hb1c9.txt cache: ./cache/cord-303363-uu9hb1c9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303363-uu9hb1c9.txt' === file2bib.sh === id: cord-303718-7bpap31f author: Binder, Adam F. title: Treating Hematologic Malignancies During a Pandemic: Utilizing Telehealth and Digital Technology to Optimize Care date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-303718-7bpap31f.txt cache: ./cache/cord-303718-7bpap31f.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303718-7bpap31f.txt' === file2bib.sh === id: cord-304602-jpxjiaru author: Anneser, Johanna title: Dying patients with COVID-19: What should Hospital Palliative Care Teams (HPCTs) be prepared for? date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-304602-jpxjiaru.txt cache: ./cache/cord-304602-jpxjiaru.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304602-jpxjiaru.txt' === file2bib.sh === id: cord-304010-n4gxxl5i author: Sung, Ho Kyung title: Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January–May 2020 date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-304010-n4gxxl5i.txt cache: ./cache/cord-304010-n4gxxl5i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304010-n4gxxl5i.txt' === file2bib.sh === id: cord-304090-l5rocsk5 author: Akbar, Aelia title: A Cross-Sectional Survey on Telemedicine Use for Doctor-Patient Communication date: 2020-09-12 pages: extension: .txt txt: ./txt/cord-304090-l5rocsk5.txt cache: ./cache/cord-304090-l5rocsk5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304090-l5rocsk5.txt' === file2bib.sh === id: cord-303483-wendrxee author: Rubin, Geoffrey D. title: The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society date: 2020-04-07 pages: extension: .txt txt: ./txt/cord-303483-wendrxee.txt cache: ./cache/cord-303483-wendrxee.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303483-wendrxee.txt' === file2bib.sh === id: cord-304949-mf3utolt author: Porzio, Giampiero title: Home Care for Cancer Patients During COVID-19 Pandemic: The Double Triage Protocol date: 2020-03-31 pages: extension: .txt txt: ./txt/cord-304949-mf3utolt.txt cache: ./cache/cord-304949-mf3utolt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-304949-mf3utolt.txt' === file2bib.sh === id: cord-304255-7xs9cit7 author: Parrish, Richard K. title: What Does Telemedicine Mean for the Care of Patients With Glaucoma in the Age of COVID-19? date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-304255-7xs9cit7.txt cache: ./cache/cord-304255-7xs9cit7.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304255-7xs9cit7.txt' === file2bib.sh === id: cord-303661-etb19d6y author: Shin, Hyoung-Shik title: Empirical Treatment and Prevention of COVID-19 date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-303661-etb19d6y.txt cache: ./cache/cord-303661-etb19d6y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-303661-etb19d6y.txt' === file2bib.sh === id: cord-304248-sxbyxnxn author: Aiolfi, Alberto title: MANAGEMENT OF PERSISTENT PNEUMOTHORAX WITH THORACOSCOPY AND BLEBS RESECTION IN COVID-19 PATIENTS date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-304248-sxbyxnxn.txt cache: ./cache/cord-304248-sxbyxnxn.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-304248-sxbyxnxn.txt' === file2bib.sh === id: cord-304474-hfv43e9m author: Marchese, Valentina title: Strongyloides infection manifested during immunosuppressive therapy for SARS-CoV-2 pneumonia date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-304474-hfv43e9m.txt cache: ./cache/cord-304474-hfv43e9m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-304474-hfv43e9m.txt' === file2bib.sh === id: cord-304271-vyayyk50 author: Qin, Yuan-Yuan title: Effectiveness of glucocorticoid therapy in patients with severe coronavirus disease 2019: protocol of a randomized controlled trial date: 2020-03-05 pages: extension: .txt txt: ./txt/cord-304271-vyayyk50.txt cache: ./cache/cord-304271-vyayyk50.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304271-vyayyk50.txt' === file2bib.sh === id: cord-303819-w1785lap author: Cortegiani, Andrea title: Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19 date: 2020-07-11 pages: extension: .txt txt: ./txt/cord-303819-w1785lap.txt cache: ./cache/cord-303819-w1785lap.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303819-w1785lap.txt' === file2bib.sh === id: cord-303703-ekhwb5xb author: Mash, Bob title: Primary care management of the coronavirus (COVID-19) date: 2020-03-31 pages: extension: .txt txt: ./txt/cord-303703-ekhwb5xb.txt cache: ./cache/cord-303703-ekhwb5xb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-303703-ekhwb5xb.txt' === file2bib.sh === id: cord-303860-jpy373ph author: Huang, Zhifeng title: Occupational Exposure to SARS-CoV-2 in Burns Treatment During the COVID-19 Epidemic: Specific Diagnosis and Treatment Protocol date: 2020-04-23 pages: extension: .txt txt: ./txt/cord-303860-jpy373ph.txt cache: ./cache/cord-303860-jpy373ph.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303860-jpy373ph.txt' === file2bib.sh === id: cord-304573-3nhglbw4 author: Bola, Sumrit title: COVID-19 and the return to head and neck outpatient activity in the United Kingdom: what is the new normal? date: 2020-11-06 pages: extension: .txt txt: ./txt/cord-304573-3nhglbw4.txt cache: ./cache/cord-304573-3nhglbw4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-304573-3nhglbw4.txt' === file2bib.sh === id: cord-303880-zv4nbz9p author: Tsikala Vafea, Maria title: Emerging Technologies for Use in the Study, Diagnosis, and Treatment of Patients with COVID-19 date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-303880-zv4nbz9p.txt cache: ./cache/cord-303880-zv4nbz9p.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-303880-zv4nbz9p.txt' === file2bib.sh === id: cord-305139-851v2qr3 author: Peys, Elise title: Haemoptysis as the first presentation of COVID-19: a case report date: 2020-10-22 pages: extension: .txt txt: ./txt/cord-305139-851v2qr3.txt cache: ./cache/cord-305139-851v2qr3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-305139-851v2qr3.txt' === file2bib.sh === id: cord-305283-1bg1ykui author: ElSeirafi, Mohamed MA. title: Efficacy and safety of tocilizumab in critically ill adults with COVID-19 infection in Bahrain: A report of 5 cases date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-305283-1bg1ykui.txt cache: ./cache/cord-305283-1bg1ykui.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305283-1bg1ykui.txt' === file2bib.sh === id: cord-304593-cugypxp0 author: Dhillon, M. S. title: Changing Pattern of Orthopaedic Trauma Admissions During COVID-19 Pandemic: Experience at a Tertiary Trauma Centre in India date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-304593-cugypxp0.txt cache: ./cache/cord-304593-cugypxp0.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-304593-cugypxp0.txt' === file2bib.sh === id: cord-303787-dx1n8jap author: Vonck, Kristl title: Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-303787-dx1n8jap.txt cache: ./cache/cord-303787-dx1n8jap.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303787-dx1n8jap.txt' === file2bib.sh === id: cord-304601-e6qlx1r6 author: Garcez, Flavia Barreto title: Delirium and adverse outcomes in hospitalized patients with COVID‐19. date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-304601-e6qlx1r6.txt cache: ./cache/cord-304601-e6qlx1r6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-304601-e6qlx1r6.txt' === file2bib.sh === id: cord-305397-4dx3q6o6 author: Ashraf, Muddasir title: Seizures Related to Coronavirus Disease (COVID-19): Case Series and Literature Review date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-305397-4dx3q6o6.txt cache: ./cache/cord-305397-4dx3q6o6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305397-4dx3q6o6.txt' === file2bib.sh === id: cord-303791-yw80ndg6 author: Ashique, Karalikkattil T. title: Teledermatology in the Wake of COVID -19 Scenario: An Indian Perspective date: 2020-05-10 pages: extension: .txt txt: ./txt/cord-303791-yw80ndg6.txt cache: ./cache/cord-303791-yw80ndg6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303791-yw80ndg6.txt' === file2bib.sh === id: cord-303816-c4z9ys3q author: Xu, YuShuang title: Diagnostic methods and drug therapies in patients with ischemic colitis date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-303816-c4z9ys3q.txt cache: ./cache/cord-303816-c4z9ys3q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303816-c4z9ys3q.txt' === file2bib.sh === id: cord-305076-v56y5nyt author: Singh, Parmvir title: Disseminated Intravascular Coagulation: A Devastating Systemic Disorder of Special Concern with COVID‐19 date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-305076-v56y5nyt.txt cache: ./cache/cord-305076-v56y5nyt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305076-v56y5nyt.txt' === file2bib.sh === id: cord-304280-2a84u4tm author: Masic, Izet title: Public Health Aspects of COVID-19 Infection with Focus on Cardiovascular Diseases date: 2020-03-17 pages: extension: .txt txt: ./txt/cord-304280-2a84u4tm.txt cache: ./cache/cord-304280-2a84u4tm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-304280-2a84u4tm.txt' === file2bib.sh === id: cord-305650-su6furzi author: Sud, Karan title: Echocardiographic Findings in COVID-19 Patients with Significant Myocardial Injury date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-305650-su6furzi.txt cache: ./cache/cord-305650-su6furzi.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-305650-su6furzi.txt' === file2bib.sh === id: cord-305520-7gxmdo56 author: Lim, Wei Sing title: Widefield imaging with Clarus fundus camera vs slit lamp fundus examination in assessing patients referred from the National Health Service diabetic retinopathy screening programme date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-305520-7gxmdo56.txt cache: ./cache/cord-305520-7gxmdo56.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305520-7gxmdo56.txt' === file2bib.sh === id: cord-304321-y177sqee author: Cho, Ryan H. W. title: Pearls of experience for safe and efficient hospital practices in otorhinolaryngology—head and neck surgery in Hong Kong during the 2019 novel coronavirus disease (COVID-19) pandemic date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-304321-y177sqee.txt cache: ./cache/cord-304321-y177sqee.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304321-y177sqee.txt' === file2bib.sh === id: cord-302382-eifh95zm author: Owji, Hajar title: Immunotherapeutic approaches to curtail COVID-19 date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-302382-eifh95zm.txt cache: ./cache/cord-302382-eifh95zm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-302382-eifh95zm.txt' === file2bib.sh === id: cord-305205-ilxxkm0f author: Cochennec, Frédéric title: Impact of intraoperative adverse events during branched and fenestrated aortic stent grafting on postoperative outcome date: 2014-09-30 pages: extension: .txt txt: ./txt/cord-305205-ilxxkm0f.txt cache: ./cache/cord-305205-ilxxkm0f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-305205-ilxxkm0f.txt' === file2bib.sh === id: cord-303054-s1clwunc author: Velly, Lionel title: Guidelines: Anaesthesia in the context of COVID-19 pandemic date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-303054-s1clwunc.txt cache: ./cache/cord-303054-s1clwunc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303054-s1clwunc.txt' === file2bib.sh === id: cord-304791-wv4qu9xm author: Carfora, Vincenzo title: Anticoagulant treatment in COVID-19: a narrative review date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-304791-wv4qu9xm.txt cache: ./cache/cord-304791-wv4qu9xm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-304791-wv4qu9xm.txt' === file2bib.sh === id: cord-306092-5bi2q3jj author: Choi, Hee Joung title: Relationship between the Clinical Characteristics and Intervention Scores of Infants with Apparent Life-threatening Events date: 2015-05-13 pages: extension: .txt txt: ./txt/cord-306092-5bi2q3jj.txt cache: ./cache/cord-306092-5bi2q3jj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-306092-5bi2q3jj.txt' === file2bib.sh === id: cord-304798-j2tyjo1j author: Rapkiewicz, Amy V. title: Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-304798-j2tyjo1j.txt cache: ./cache/cord-304798-j2tyjo1j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304798-j2tyjo1j.txt' === file2bib.sh === id: cord-306090-i8sriw08 author: Tan, Zihui title: Protecting health care workers in the front line: Innovation in COVID-19 pandemic date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-306090-i8sriw08.txt cache: ./cache/cord-306090-i8sriw08.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306090-i8sriw08.txt' === file2bib.sh === id: cord-303517-8971aq02 author: Cajamarca-Baron, Jairo title: SARS-CoV-2 (COVID-19) in Patients with some Degree of Immunosuppression date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-303517-8971aq02.txt cache: ./cache/cord-303517-8971aq02.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303517-8971aq02.txt' === file2bib.sh === id: cord-304418-k9owyolj author: Le Maréchal, M. title: COVID-19 in clinical practice: a narrative synthesis date: 2020-09-29 pages: extension: .txt txt: ./txt/cord-304418-k9owyolj.txt cache: ./cache/cord-304418-k9owyolj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304418-k9owyolj.txt' === file2bib.sh === id: cord-305498-8tmtvw1r author: Singh Saraj, K. title: Modification of Neurosurgical Practice during Corona Pandemic: Our Experience at AIIMS Patna And Long Term Guidelines date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-305498-8tmtvw1r.txt cache: ./cache/cord-305498-8tmtvw1r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305498-8tmtvw1r.txt' === file2bib.sh === id: cord-306595-ru725fbr author: Ammor, Othmane title: Hidroxicloroquina / cloroquina y azitromicina en pacientes con COVID-19: estudio prospectivo de parámetros eléctricos date: 2020-09-11 pages: extension: .txt txt: ./txt/cord-306595-ru725fbr.txt cache: ./cache/cord-306595-ru725fbr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-306595-ru725fbr.txt' === file2bib.sh === id: cord-305838-i0ck2oo0 author: Kouri, Andrew title: CHEST Reviews: Addressing reduced laboratory-based pulmonary function testing during a pandemic date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-305838-i0ck2oo0.txt cache: ./cache/cord-305838-i0ck2oo0.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-305838-i0ck2oo0.txt' === file2bib.sh === id: cord-306149-sd0s0jup author: Ratanarat, Ranistha title: Critical Care Management of Patients with COVID-19: Early Experience in Thailand date: 2020-05-18 pages: extension: .txt txt: ./txt/cord-306149-sd0s0jup.txt cache: ./cache/cord-306149-sd0s0jup.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306149-sd0s0jup.txt' === file2bib.sh === id: cord-304457-8g36h1bz author: Idelsis, E.-M. title: Effect and safety of combination of interferon alpha-2b and gamma or interferon alpha-2b for negativization of SARS-CoV-2 viral RNA. Preliminary results of a randomized controlled clinical trial. date: 2020-08-01 pages: extension: .txt txt: ./txt/cord-304457-8g36h1bz.txt cache: ./cache/cord-304457-8g36h1bz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304457-8g36h1bz.txt' === file2bib.sh === id: cord-305405-me4gebvm author: Conway, J. title: Characteristics of patients with diabetes hospitalised for COVID-19 infection-a brief case series report date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-305405-me4gebvm.txt cache: ./cache/cord-305405-me4gebvm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-305405-me4gebvm.txt' === file2bib.sh === id: cord-306790-82nltfk3 author: Sheikh, Abu Baker title: Inferior Wall Myocardial Infarction in Severe COVID-19 Infection: A Case Report date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-306790-82nltfk3.txt cache: ./cache/cord-306790-82nltfk3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-306790-82nltfk3.txt' === file2bib.sh === id: cord-304972-aktfbriw author: Cots, Josep M. title: Recommendations for Management of Acute Pharyngitis in Adults date: 2015-06-30 pages: extension: .txt txt: ./txt/cord-304972-aktfbriw.txt cache: ./cache/cord-304972-aktfbriw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-304972-aktfbriw.txt' === file2bib.sh === id: cord-305479-o47mv4uw author: Feng, Xiaobo title: Clinical Characteristics and Short-Term Outcomes of Severe Patients With COVID-19 in Wuhan, China date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-305479-o47mv4uw.txt cache: ./cache/cord-305479-o47mv4uw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305479-o47mv4uw.txt' === file2bib.sh === id: cord-305304-d3x734nu author: Birnbaum, Yochai title: Inferior ST-Elevation Myocardial Infarction Presenting When Urgent Primary Percutaneous Coronary Intervention Is Unavailable: Should We Adhere to Current Guidelines? date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-305304-d3x734nu.txt cache: ./cache/cord-305304-d3x734nu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305304-d3x734nu.txt' === file2bib.sh === id: cord-306646-6c7n0xir author: Crimi, Claudia title: Resumption of Respiratory Outpatient Services in the COVID-19 era: experience from Southern Italy date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-306646-6c7n0xir.txt cache: ./cache/cord-306646-6c7n0xir.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306646-6c7n0xir.txt' === file2bib.sh === id: cord-305134-s7h6bpof author: Mackman, Nigel title: Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-305134-s7h6bpof.txt cache: ./cache/cord-305134-s7h6bpof.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-305134-s7h6bpof.txt' === file2bib.sh === id: cord-305959-x061q8t7 author: Davoudi-Monfared, Effat title: A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19 date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-305959-x061q8t7.txt cache: ./cache/cord-305959-x061q8t7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-305959-x061q8t7.txt' === file2bib.sh === id: cord-306062-g9hk1iq5 author: Silverman, Dustin A. title: Respiratory and pulmonary complications in head and neck cancer patients: Evidence‐based review for the COVID‐19 era date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-306062-g9hk1iq5.txt cache: ./cache/cord-306062-g9hk1iq5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306062-g9hk1iq5.txt' === file2bib.sh === id: cord-307217-0agij3z3 author: Sun, Qiulian title: Evolution of computed tomography manifestations of eleven patients with severe coronavirus disease 2019 (COVID‐19) pneumonia date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-307217-0agij3z3.txt cache: ./cache/cord-307217-0agij3z3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-307217-0agij3z3.txt' === file2bib.sh === id: cord-306154-nm0g79ih author: JEGANATHAN, Sumithra title: Adherence and Acceptability of Telehealth Appointments for High Risk Obstetrical Patients During the COVID-19 Pandemic date: 2020-09-22 pages: extension: .txt txt: ./txt/cord-306154-nm0g79ih.txt cache: ./cache/cord-306154-nm0g79ih.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-306154-nm0g79ih.txt' === file2bib.sh === id: cord-307100-w33e2078 author: Douedi, Steven title: Successful Maternal and Fetal Outcomes in COVID-19 Pregnant Women: An Institutional Approach date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-307100-w33e2078.txt cache: ./cache/cord-307100-w33e2078.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-307100-w33e2078.txt' === file2bib.sh === id: cord-306670-c2jm0g88 author: Zhang, Yan title: Association of Diabetes Mellitus with Disease Severity and Prognosis in COVID-19: A Retrospective Cohort Study date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-306670-c2jm0g88.txt cache: ./cache/cord-306670-c2jm0g88.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306670-c2jm0g88.txt' === file2bib.sh === id: cord-308390-ei96iuw3 author: Wu, Junping title: Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-308390-ei96iuw3.txt cache: ./cache/cord-308390-ei96iuw3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308390-ei96iuw3.txt' === file2bib.sh === id: cord-302403-kahi8cbc author: Miller, Robert F. title: Pulmonary Infections date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-302403-kahi8cbc.txt cache: ./cache/cord-302403-kahi8cbc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302403-kahi8cbc.txt' === file2bib.sh === id: cord-307660-onz6vfre author: Titanji, Boghuma K title: Use of Baricitinib in Patients with Moderate and Severe COVID-19 date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-307660-onz6vfre.txt cache: ./cache/cord-307660-onz6vfre.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-307660-onz6vfre.txt' === file2bib.sh === id: cord-010980-sizuef1v author: nan title: ECTES Abstracts 2020 date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-010980-sizuef1v.txt cache: ./cache/cord-010980-sizuef1v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-010980-sizuef1v.txt' === file2bib.sh === id: cord-306108-ja0wyr5w author: B K, Anupama title: A Review of Acute Myocardial Injury in Coronavirus Disease 2019 date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-306108-ja0wyr5w.txt cache: ./cache/cord-306108-ja0wyr5w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306108-ja0wyr5w.txt' === file2bib.sh === id: cord-308112-w96ncfla author: Gautret, Philippe title: Nullane salus extra ecclesiam date: 2020-08-01 pages: extension: .txt txt: ./txt/cord-308112-w96ncfla.txt cache: ./cache/cord-308112-w96ncfla.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-308112-w96ncfla.txt' === file2bib.sh === id: cord-306896-khn8epxd author: D'Souza, Ayman title: Tracheostomy intervention in intubated COVID positive patients: A survey of current clinical practice among ENT surgeons date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-306896-khn8epxd.txt cache: ./cache/cord-306896-khn8epxd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306896-khn8epxd.txt' === file2bib.sh === id: cord-306016-2gudro8v author: Pelt, Christopher E. title: The Rapid Response to the COVID-19 Pandemic by the Arthroplasty Divisions at Two Academic Referral Centers date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-306016-2gudro8v.txt cache: ./cache/cord-306016-2gudro8v.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306016-2gudro8v.txt' === file2bib.sh === id: cord-306377-s9j21zsy author: Yan, Li title: A machine learning-based model for survival prediction in patients with severe COVID-19 infection date: 2020-03-01 pages: extension: .txt txt: ./txt/cord-306377-s9j21zsy.txt cache: ./cache/cord-306377-s9j21zsy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306377-s9j21zsy.txt' === file2bib.sh === id: cord-305582-3hmsknon author: Li, Lei title: Therapeutic strategies for critically ill patients with COVID-19 date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-305582-3hmsknon.txt cache: ./cache/cord-305582-3hmsknon.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305582-3hmsknon.txt' === file2bib.sh === id: cord-307258-66lwpblq author: Li, Weixia title: Anesthesia Management and Perioperative Infection Control in Patients With the Novel Coronavirus date: 2020-03-29 pages: extension: .txt txt: ./txt/cord-307258-66lwpblq.txt cache: ./cache/cord-307258-66lwpblq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-307258-66lwpblq.txt' === file2bib.sh === id: cord-306997-84pjfawk author: Melazzini, Federica title: Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy date: 2020-11-08 pages: extension: .txt txt: ./txt/cord-306997-84pjfawk.txt cache: ./cache/cord-306997-84pjfawk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306997-84pjfawk.txt' === file2bib.sh === id: cord-307160-1vz0gw1w author: Morais-Almeida, Mário title: COVID-19, asthma, and biologic therapies: What we need to know date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-307160-1vz0gw1w.txt cache: ./cache/cord-307160-1vz0gw1w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-307160-1vz0gw1w.txt' === file2bib.sh === id: cord-304479-uxp1kg86 author: Goodarzi, Pedram title: Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-304479-uxp1kg86.txt cache: ./cache/cord-304479-uxp1kg86.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-304479-uxp1kg86.txt' === file2bib.sh === id: cord-307653-nyr6mtj1 author: Palmeira, Patricia title: Why is SARS-CoV-2 infection milder among children? date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-307653-nyr6mtj1.txt cache: ./cache/cord-307653-nyr6mtj1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-307653-nyr6mtj1.txt' === file2bib.sh === id: cord-307862-a082sghm author: ten Cate, Hugo title: Thrombosis management in times of COVID-19 epidemy; a Dutch perspective date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-307862-a082sghm.txt cache: ./cache/cord-307862-a082sghm.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-307862-a082sghm.txt' === file2bib.sh === id: cord-308010-ix0xi5jb author: Mcloughlin, Benjamin C. title: Functional and cognitive outcomes after COVID-19 delirium date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-308010-ix0xi5jb.txt cache: ./cache/cord-308010-ix0xi5jb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-308010-ix0xi5jb.txt' === file2bib.sh === id: cord-308907-elz62jlg author: Joob, Beuy title: 2019 Novel coronavirus and awareness date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-308907-elz62jlg.txt cache: ./cache/cord-308907-elz62jlg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-308907-elz62jlg.txt' === file2bib.sh === id: cord-308071-1bk3xuwf author: Lang, Christian title: Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-308071-1bk3xuwf.txt cache: ./cache/cord-308071-1bk3xuwf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308071-1bk3xuwf.txt' === file2bib.sh === id: cord-308184-w8ewm8ve author: Sarzi-Puttini, Piercarlo title: How to handle patients with autoimmune rheumatic and inflammatory bowel diseases in the COVID-19 era: An expert opinion date: 2020-05-05 pages: extension: .txt txt: ./txt/cord-308184-w8ewm8ve.txt cache: ./cache/cord-308184-w8ewm8ve.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308184-w8ewm8ve.txt' === file2bib.sh === id: cord-308212-l8flyso7 author: Kong, Ha Eun title: Applying the ethical principles of resource allocation to drugs in limited supply during a public health crisis date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-308212-l8flyso7.txt cache: ./cache/cord-308212-l8flyso7.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-308212-l8flyso7.txt' === file2bib.sh === id: cord-305534-936peb1n author: Johnson, Kemmian D. title: Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19 date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-305534-936peb1n.txt cache: ./cache/cord-305534-936peb1n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-305534-936peb1n.txt' === file2bib.sh === id: cord-307758-a4sgt66g author: Hong, Ching-Ye title: Acute respiratory symptoms in adults in general practice date: 2004-06-17 pages: extension: .txt txt: ./txt/cord-307758-a4sgt66g.txt cache: ./cache/cord-307758-a4sgt66g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-307758-a4sgt66g.txt' === file2bib.sh === id: cord-307285-bxy0zsc7 author: Dar Odeh, Najla title: COVID-19: Present and Future Challenges for Dental Practice date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-307285-bxy0zsc7.txt cache: ./cache/cord-307285-bxy0zsc7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-307285-bxy0zsc7.txt' === file2bib.sh === id: cord-305422-t8azymo7 author: Yi, Ye title: COVID-19: what has been learned and to be learned about the novel coronavirus disease date: 2020-03-15 pages: extension: .txt txt: ./txt/cord-305422-t8azymo7.txt cache: ./cache/cord-305422-t8azymo7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305422-t8azymo7.txt' === file2bib.sh === id: cord-307309-s0t4kp2x author: Liang, Ying title: Symptoms, Management and Healthcare Utilization of COPD Patients During the COVID-19 Epidemic in Beijing date: 2020-10-14 pages: extension: .txt txt: ./txt/cord-307309-s0t4kp2x.txt cache: ./cache/cord-307309-s0t4kp2x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-307309-s0t4kp2x.txt' === file2bib.sh === id: cord-307710-dlpfbnb1 author: Neradi, Deepak title: Management of Orthopaedic Patients During COVID-19 Pandemic in India: A Guide date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-307710-dlpfbnb1.txt cache: ./cache/cord-307710-dlpfbnb1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-307710-dlpfbnb1.txt' === file2bib.sh === id: cord-308002-abgv87e4 author: Porta, Camillo title: Editorial debate: Challenges an oncologist has to face during the SARS-CoV-2 pandemic within a universal healthcare system date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-308002-abgv87e4.txt cache: ./cache/cord-308002-abgv87e4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-308002-abgv87e4.txt' === file2bib.sh === id: cord-304399-7t2mu13s author: Wynne, Keona Jeane title: Dying individuals and suffering populations: applying a population-level bioethics lens to palliative care in humanitarian contexts: before, during and after the COVID-19 pandemic date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-304399-7t2mu13s.txt cache: ./cache/cord-304399-7t2mu13s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-304399-7t2mu13s.txt' === file2bib.sh === id: cord-307808-0t6sw0zp author: Romanick-Schmiedl, Sue title: Telemedicine — maintaining quality during times of transition date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-307808-0t6sw0zp.txt cache: ./cache/cord-307808-0t6sw0zp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-307808-0t6sw0zp.txt' === file2bib.sh === id: cord-307690-1qqyixun author: Preti, Emanuele title: Personality Disorders in Time of Pandemic date: 2020-11-10 pages: extension: .txt txt: ./txt/cord-307690-1qqyixun.txt cache: ./cache/cord-307690-1qqyixun.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-307690-1qqyixun.txt' === file2bib.sh === id: cord-308252-qwoo7b1l author: Cardinale, Vincenzo title: Intestinal permeability changes with bacterial translocation as key events modulating systemic host immune response to SARS-CoV-2: A working hypothesis date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-308252-qwoo7b1l.txt cache: ./cache/cord-308252-qwoo7b1l.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-308252-qwoo7b1l.txt' === file2bib.sh === id: cord-309207-n8u8ddv7 author: Lechien, Jerome R. title: Loss of Smell and Taste in 2013 European Patients With Mild to Moderate COVID-19 date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-309207-n8u8ddv7.txt cache: ./cache/cord-309207-n8u8ddv7.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-309207-n8u8ddv7.txt' === file2bib.sh === id: cord-306351-ka6asw3m author: Alsuliman, Tamim title: A review of potential treatments to date in COVID-19 patients according to the stage of the disease date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-306351-ka6asw3m.txt cache: ./cache/cord-306351-ka6asw3m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306351-ka6asw3m.txt' === file2bib.sh === id: cord-308075-1ftswsm8 author: Segura, Patricia Sanz title: Involvement of the digestive system in COVID-19. A review date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-308075-1ftswsm8.txt cache: ./cache/cord-308075-1ftswsm8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308075-1ftswsm8.txt' === file2bib.sh === id: cord-307287-zpq6byml author: Poulsen, Nadia Nicholine title: Cyclosporine and COVID‐19: Risk or Favorable? date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-307287-zpq6byml.txt cache: ./cache/cord-307287-zpq6byml.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-307287-zpq6byml.txt' === file2bib.sh === id: cord-305786-06dpjik8 author: Sandora, Thomas J. title: Pneumonia in Hospitalized Children date: 2005-07-09 pages: extension: .txt txt: ./txt/cord-305786-06dpjik8.txt cache: ./cache/cord-305786-06dpjik8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-305786-06dpjik8.txt' === file2bib.sh === id: cord-308195-nlibv0u4 author: Arleo, T. L. title: Clinical Course and Outcomes of coronavirus disease 2019 (COVID-19) in Rheumatic Disease Patients on Immunosuppression: A case Cohort Study at a Single Center with a Significantly Diverse Population date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-308195-nlibv0u4.txt cache: ./cache/cord-308195-nlibv0u4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308195-nlibv0u4.txt' === file2bib.sh === id: cord-309214-v2iqgjc4 author: Nougier, Christophe title: Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-309214-v2iqgjc4.txt cache: ./cache/cord-309214-v2iqgjc4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-309214-v2iqgjc4.txt' === file2bib.sh === id: cord-023354-f2ciho6o author: nan title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 pages: extension: .txt txt: ./txt/cord-023354-f2ciho6o.txt cache: ./cache/cord-023354-f2ciho6o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-023354-f2ciho6o.txt' === file2bib.sh === id: cord-308491-fc46k594 author: Mossa-Basha, Mahmud title: Policies and Guidelines for COVID-19 Preparedness: Experiences from the University of Washington date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-308491-fc46k594.txt cache: ./cache/cord-308491-fc46k594.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308491-fc46k594.txt' === file2bib.sh === id: cord-309236-p4c2d5y3 author: Khurram, Ruhaid title: Spontaneous tension pneumothorax and acute pulmonary emboli in a patient with COVID-19 infection date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-309236-p4c2d5y3.txt cache: ./cache/cord-309236-p4c2d5y3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309236-p4c2d5y3.txt' === file2bib.sh === id: cord-308313-3speddao author: Jaspard, Marie title: Linezolid-Associated Neurologic Adverse Events in Patients with Multidrug-Resistant Tuberculosis, France date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-308313-3speddao.txt cache: ./cache/cord-308313-3speddao.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308313-3speddao.txt' === file2bib.sh === id: cord-308906-et7duogt author: Di, Gaohong title: Simple and Effective Primary Assessment of Emergency Patients in a COVID-19 Outbreak Area: A Retrospective, Observational Study date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-308906-et7duogt.txt cache: ./cache/cord-308906-et7duogt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-308906-et7duogt.txt' === file2bib.sh === id: cord-309370-g8d3w7it author: Insausti-García, Alfredo title: Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-309370-g8d3w7it.txt cache: ./cache/cord-309370-g8d3w7it.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309370-g8d3w7it.txt' === file2bib.sh === id: cord-309001-erm705tg author: Liu, Q. title: Laboratory findings and a combined multifactorial approach to predict death in critically ill patients with COVID-19: a retrospective study date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-309001-erm705tg.txt cache: ./cache/cord-309001-erm705tg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-309001-erm705tg.txt' === file2bib.sh === id: cord-309026-l2rh9bie author: Sweiss, Nadera J. title: When the game changes: Guidance to adjust sarcoidosis management during the COVID-19 pandemic date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-309026-l2rh9bie.txt cache: ./cache/cord-309026-l2rh9bie.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309026-l2rh9bie.txt' === file2bib.sh === id: cord-309507-oe4i6v5x author: Sacchelli, L. title: Sexually Transmitted Infections during the COVID‐19 outbreak: comparison of patients referring to the service of sexually transmitted diseases during the sanitary emergency with those referring during the common practice date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-309507-oe4i6v5x.txt cache: ./cache/cord-309507-oe4i6v5x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-309507-oe4i6v5x.txt' === file2bib.sh === id: cord-309561-m43v332d author: Cuffaro, Luca title: Dementia care and COVID-19 pandemic: a necessary digital revolution date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-309561-m43v332d.txt cache: ./cache/cord-309561-m43v332d.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309561-m43v332d.txt' === file2bib.sh === id: cord-308169-a0ft6wdy author: Custovic, A. title: EAACI position statement on asthma exacerbations and severe asthma date: 2013-11-06 pages: extension: .txt txt: ./txt/cord-308169-a0ft6wdy.txt cache: ./cache/cord-308169-a0ft6wdy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-308169-a0ft6wdy.txt' === file2bib.sh === id: cord-308979-qhlvd2mt author: Sumino, Kaharu C. title: Detection of Severe Human Metapneumovirus Infection by Real-Time Polymerase Chain Reaction and Histopathological Assessment date: 2005-09-15 pages: extension: .txt txt: ./txt/cord-308979-qhlvd2mt.txt cache: ./cache/cord-308979-qhlvd2mt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308979-qhlvd2mt.txt' === file2bib.sh === id: cord-309024-pu830bn9 author: Bernardo, Luca title: Severe prolonged neutropenia following administration of tocilizumab in a patient affected by COVID-19: a case report and brief review of the literature date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-309024-pu830bn9.txt cache: ./cache/cord-309024-pu830bn9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309024-pu830bn9.txt' === file2bib.sh === id: cord-308445-3j2q83ll author: Rhim, Jung-Woo title: Pandemic 2009 H1N1 virus infection in children and adults: A cohort study at a single hospital throughout the epidemic date: 2012-03-26 pages: extension: .txt txt: ./txt/cord-308445-3j2q83ll.txt cache: ./cache/cord-308445-3j2q83ll.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308445-3j2q83ll.txt' === file2bib.sh === id: cord-309735-bwa1zo07 author: Cerfolio, Robert J. title: Many Ways to Skin A Cat date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-309735-bwa1zo07.txt cache: ./cache/cord-309735-bwa1zo07.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-309735-bwa1zo07.txt' === file2bib.sh === id: cord-309194-jtouafgd author: Lu, Xiao title: Lung ultrasound score in establishing the timing of intubation in COVID-19 interstitial pneumonia: A preliminary retrospective observational study date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-309194-jtouafgd.txt cache: ./cache/cord-309194-jtouafgd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-309194-jtouafgd.txt' === file2bib.sh === id: cord-306266-8qdrshz3 author: Scully, Crispian title: Respiratory medicine date: 2014-06-25 pages: extension: .txt txt: ./txt/cord-306266-8qdrshz3.txt cache: ./cache/cord-306266-8qdrshz3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-306266-8qdrshz3.txt' === file2bib.sh === id: cord-310010-oxgb6xnv author: Dalmau, Josep title: “Time to recharge” date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-310010-oxgb6xnv.txt cache: ./cache/cord-310010-oxgb6xnv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310010-oxgb6xnv.txt' === file2bib.sh === id: cord-309395-5yan9fcn author: Kazory, Amir title: SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill date: 2020-04-16 pages: extension: .txt txt: ./txt/cord-309395-5yan9fcn.txt cache: ./cache/cord-309395-5yan9fcn.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309395-5yan9fcn.txt' === file2bib.sh === id: cord-308803-i934doud author: PONNAPA REDDY, M. title: Prone positioning of non-intubated patients with COVID-19 - A Systematic Review and Meta-analysis date: 2020-10-14 pages: extension: .txt txt: ./txt/cord-308803-i934doud.txt cache: ./cache/cord-308803-i934doud.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308803-i934doud.txt' === file2bib.sh === id: cord-309706-kikx05dj author: MacDonald, Scott title: Implementing a 2019 coronavirus disease airway management strategy for a provincial critical care and ground transport program date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-309706-kikx05dj.txt cache: ./cache/cord-309706-kikx05dj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309706-kikx05dj.txt' === file2bib.sh === id: cord-309441-obojsf04 author: Pirau, Letitia title: Case Series: Evidence of Borderzone Ischemia in Critically-Ill COVID-19 Patients Who “Do Not Wake Up” date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-309441-obojsf04.txt cache: ./cache/cord-309441-obojsf04.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309441-obojsf04.txt' === file2bib.sh === id: cord-309482-frawgvk7 author: Cook, T. M. title: Kicking on while it’s still kicking off – getting surgery and anaesthesia restarted after COVID‐19 date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-309482-frawgvk7.txt cache: ./cache/cord-309482-frawgvk7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309482-frawgvk7.txt' === file2bib.sh === id: cord-309962-phwq8rsf author: Vetter, Monica Hagan title: Chemotherapy directly followed by PARP inhibition as an alternative to surgery in patients with BRCA- mutated ovarian cancer – a potential management strategy in the era of COVID-19 date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-309962-phwq8rsf.txt cache: ./cache/cord-309962-phwq8rsf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-309962-phwq8rsf.txt' === file2bib.sh === id: cord-309238-7lbt0f03 author: Koratala, Abhilash title: Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19: The Tri-POCUS Approach date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-309238-7lbt0f03.txt cache: ./cache/cord-309238-7lbt0f03.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309238-7lbt0f03.txt' === file2bib.sh === id: cord-310069-ay4af6xr author: Tobin, Martin J. title: Does making a diagnosis of ARDS in COVID-19 patients matter? date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-310069-ay4af6xr.txt cache: ./cache/cord-310069-ay4af6xr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-310069-ay4af6xr.txt' === file2bib.sh === id: cord-309360-cpis1l4u author: Barrios-López, J. M. title: Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association? date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-309360-cpis1l4u.txt cache: ./cache/cord-309360-cpis1l4u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-309360-cpis1l4u.txt' === file2bib.sh === id: cord-310001-qng7h5cj author: Tomlins, Jennifer title: Clinical features of 95 sequential hospitalised patients with novel coronavirus 2019 disease (COVID-19), the first UK cohort date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-310001-qng7h5cj.txt cache: ./cache/cord-310001-qng7h5cj.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-310001-qng7h5cj.txt' === file2bib.sh === id: cord-310891-yfouizjb author: Korada, Sai Krishna C. title: Management of COVID-19 in a Durable Left Ventricular Assist Device Recipient: A Continuity of Care Perspective date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-310891-yfouizjb.txt cache: ./cache/cord-310891-yfouizjb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310891-yfouizjb.txt' === file2bib.sh === id: cord-310823-xksu8fn1 author: Anand, Abhinav title: Obesity and mortality in COVID-19: cause or association? date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-310823-xksu8fn1.txt cache: ./cache/cord-310823-xksu8fn1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-310823-xksu8fn1.txt' === file2bib.sh === id: cord-309421-725u6dau author: Wechsler, Michael E. title: SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-309421-725u6dau.txt cache: ./cache/cord-309421-725u6dau.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-309421-725u6dau.txt' === file2bib.sh === id: cord-310117-19qsszns author: Huang, Yao title: Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-310117-19qsszns.txt cache: ./cache/cord-310117-19qsszns.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-310117-19qsszns.txt' === file2bib.sh === id: cord-309728-7vfotgrr author: Johnson, Kristen M. title: Managing COVID‐19 in Renal Transplant Recipients: A Review of Recent Literature and Case Supporting Corticosteroid‐sparing Immunosuppression date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-309728-7vfotgrr.txt cache: ./cache/cord-309728-7vfotgrr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309728-7vfotgrr.txt' === file2bib.sh === id: cord-310166-gt6icwul author: Yang, Xiang-Hong title: Expert recommendations on blood purification treatment protocol for patients with severe COVID-19(): Recommendation and consensus date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-310166-gt6icwul.txt cache: ./cache/cord-310166-gt6icwul.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310166-gt6icwul.txt' === file2bib.sh === id: cord-309302-n6cd2fc3 author: Wang, Li title: Clinical management of lung cancer patients during the outbreak of COVID-19 epidemic date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-309302-n6cd2fc3.txt cache: ./cache/cord-309302-n6cd2fc3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-309302-n6cd2fc3.txt' === file2bib.sh === id: cord-309517-yh4d414y author: Yu, Chao title: Characteristics of asymptomatic COVID-19 infection and progression: A multicenter, retrospective study date: 2020-08-12 pages: extension: .txt txt: ./txt/cord-309517-yh4d414y.txt cache: ./cache/cord-309517-yh4d414y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309517-yh4d414y.txt' === file2bib.sh === id: cord-310597-zy6ckr53 author: Essa, Hani title: Hypertension management in cardio-oncology date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-310597-zy6ckr53.txt cache: ./cache/cord-310597-zy6ckr53.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-310597-zy6ckr53.txt' === file2bib.sh === id: cord-310084-taaz6mhs author: Fatehi, Poya title: Acute Ischemic and Hemorrhagic Stroke and COVID-19: Case Series date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-310084-taaz6mhs.txt cache: ./cache/cord-310084-taaz6mhs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310084-taaz6mhs.txt' === file2bib.sh === id: cord-309323-yflng8m3 author: Thomas, T. title: COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-309323-yflng8m3.txt cache: ./cache/cord-309323-yflng8m3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309323-yflng8m3.txt' === file2bib.sh === id: cord-310661-hrvuhkq9 author: Patell, Rushad title: Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID‐19 date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-310661-hrvuhkq9.txt cache: ./cache/cord-310661-hrvuhkq9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-310661-hrvuhkq9.txt' === file2bib.sh === id: cord-310405-7fah22nu author: Mathur, Sachin title: Development of an enhanced Acute Care Surgery service in response to the COVID-19 global pandemic: Assessment of clinical patient outcomes and staff psychological well-being date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-310405-7fah22nu.txt cache: ./cache/cord-310405-7fah22nu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-310405-7fah22nu.txt' === file2bib.sh === id: cord-310539-8zk3hkgj author: Barengolts, Elena title: PERSEVERE OR PERIL: DIABETES CARE IN TIMES OF COVID-19 date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-310539-8zk3hkgj.txt cache: ./cache/cord-310539-8zk3hkgj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-310539-8zk3hkgj.txt' === file2bib.sh === id: cord-308968-m4pzsfkd author: Mercadante, Amanda R. title: Choosing Evolution over Extinction: Integrating Direct Patient Care Services and Value-Based Payment Models into the Community-Based Pharmacy Setting date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-308968-m4pzsfkd.txt cache: ./cache/cord-308968-m4pzsfkd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308968-m4pzsfkd.txt' === file2bib.sh === id: cord-310240-otf9ruvj author: Prohaska, Stefanie title: Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy date: 2018-02-26 pages: extension: .txt txt: ./txt/cord-310240-otf9ruvj.txt cache: ./cache/cord-310240-otf9ruvj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310240-otf9ruvj.txt' === file2bib.sh === id: cord-309751-7elnvjk3 author: Abdelnasser, Mohammad Kamal title: COVID-19. An update for orthopedic surgeons date: 2020-07-01 pages: extension: .txt txt: ./txt/cord-309751-7elnvjk3.txt cache: ./cache/cord-309751-7elnvjk3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-309751-7elnvjk3.txt' === file2bib.sh === id: cord-308466-f0iu6sje author: Ko, Fanny W. title: Acute exacerbation of COPD date: 2016-03-30 pages: extension: .txt txt: ./txt/cord-308466-f0iu6sje.txt cache: ./cache/cord-308466-f0iu6sje.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-308466-f0iu6sje.txt' === file2bib.sh === id: cord-309829-3dlfcy31 author: Parupudi, Tejasvi title: Evidence-based point-of-care technology development during the COVID-19 pandemic date: 2020-11-09 pages: extension: .txt txt: ./txt/cord-309829-3dlfcy31.txt cache: ./cache/cord-309829-3dlfcy31.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-309829-3dlfcy31.txt' === file2bib.sh === id: cord-310976-24b3c3a4 author: Parikh, Neil R. title: Time-Driven Activity-Based Costing Analysis of Telemedicine Services in Radiation Oncology date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-310976-24b3c3a4.txt cache: ./cache/cord-310976-24b3c3a4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310976-24b3c3a4.txt' === file2bib.sh === id: cord-310974-hz37yf39 author: Crolley, Valerie E. title: COVID-19 in cancer patients on systemic anti-cancer therapies: outcomes from the CAPITOL (COVID-19 Cancer PatIenT Outcomes in North London) cohort study date: 2020-10-23 pages: extension: .txt txt: ./txt/cord-310974-hz37yf39.txt cache: ./cache/cord-310974-hz37yf39.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-310974-hz37yf39.txt' === file2bib.sh === id: cord-311373-ngs7baoc author: Hu, Nannan title: Emergency Management of Mental Hospitals during the Outbreak of COVID-19 date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-311373-ngs7baoc.txt cache: ./cache/cord-311373-ngs7baoc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-311373-ngs7baoc.txt' === file2bib.sh === id: cord-310917-9sk8gdh8 author: Ahmed, Kamran title: Global challenges to urology practice during the COVID‐19 pandemic date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-310917-9sk8gdh8.txt cache: ./cache/cord-310917-9sk8gdh8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310917-9sk8gdh8.txt' === file2bib.sh === id: cord-311043-nidu7om2 author: Erdinc, Burak title: Spontaneous Retroperitoneal Bleed Coincided With Massive Acute Deep Vein Thrombosis as Initial Presentation of COVID-19 date: 2020-08-15 pages: extension: .txt txt: ./txt/cord-311043-nidu7om2.txt cache: ./cache/cord-311043-nidu7om2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311043-nidu7om2.txt' === file2bib.sh === id: cord-311275-ysr9nqun author: Chuaychoo, Benjamas title: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients date: 2019-07-03 pages: extension: .txt txt: ./txt/cord-311275-ysr9nqun.txt cache: ./cache/cord-311275-ysr9nqun.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311275-ysr9nqun.txt' === file2bib.sh === id: cord-311341-7ox30d2u author: Goenka, Anuj title: Implementation of Telehealth in Radiation Oncology: Rapid Integration During COVID-19 and its Future Role in our Practice date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-311341-7ox30d2u.txt cache: ./cache/cord-311341-7ox30d2u.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311341-7ox30d2u.txt' === file2bib.sh === id: cord-310779-4puiao40 author: Mehta, Pooja title: Telehealth and Nutrition Support During the Covid-19 Pandemic date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-310779-4puiao40.txt cache: ./cache/cord-310779-4puiao40.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-310779-4puiao40.txt' === file2bib.sh === id: cord-310902-cfci8lef author: Freites Nuñez, Dalifer D title: Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-310902-cfci8lef.txt cache: ./cache/cord-310902-cfci8lef.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310902-cfci8lef.txt' === file2bib.sh === id: cord-311579-4jhoatkw author: Bhatt, Harshil title: Venous thromboembolism and COVID-19: a case report and review of the literature date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-311579-4jhoatkw.txt cache: ./cache/cord-311579-4jhoatkw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-311579-4jhoatkw.txt' === file2bib.sh === id: cord-310901-oooat8xj author: Arca, Karissa N. title: COVID‐19 and Headache Medicine: A Narrative Review of Non‐Steroidal Anti‐Inflammatory Drug (NSAID) and Corticosteroid Use date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-310901-oooat8xj.txt cache: ./cache/cord-310901-oooat8xj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310901-oooat8xj.txt' === file2bib.sh === id: cord-310676-125o0o7x author: Liu, Qibin title: Prediction of the clinical outcome of COVID-19 patients using T lymphocyte subsets with 340 cases from Wuhan, China: a retrospective cohort study and a web visualization tool date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-310676-125o0o7x.txt cache: ./cache/cord-310676-125o0o7x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-310676-125o0o7x.txt' === file2bib.sh === id: cord-311730-189vax2m author: Becker, Richard C. title: Covid-19 treatment update: follow the scientific evidence date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-311730-189vax2m.txt cache: ./cache/cord-311730-189vax2m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-311730-189vax2m.txt' === file2bib.sh === id: cord-311418-7core0y3 author: Kutsenko, Oleksandra title: Guest Editorial: Radiology Nurses Can Raise the Impact on Promoting IR date: 2020-04-02 pages: extension: .txt txt: ./txt/cord-311418-7core0y3.txt cache: ./cache/cord-311418-7core0y3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311418-7core0y3.txt' === file2bib.sh === id: cord-311074-j3fw4dfc author: Alviset, Sophie title: Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study date: 2020-10-14 pages: extension: .txt txt: ./txt/cord-311074-j3fw4dfc.txt cache: ./cache/cord-311074-j3fw4dfc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311074-j3fw4dfc.txt' === file2bib.sh === id: cord-310690-50z2kdaj author: Maschmeyer, Georg title: How to manage lung infiltrates in adults suffering from haematological malignancies outside allogeneic haematopoietic stem cell transplantation date: 2016-01-05 pages: extension: .txt txt: ./txt/cord-310690-50z2kdaj.txt cache: ./cache/cord-310690-50z2kdaj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-310690-50z2kdaj.txt' === file2bib.sh === id: cord-311215-x3b7ewo2 author: Chao, Tiffany N. title: Tracheotomy in Ventilated Patients With COVID-19 date: 2020-05-05 pages: extension: .txt txt: ./txt/cord-311215-x3b7ewo2.txt cache: ./cache/cord-311215-x3b7ewo2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-311215-x3b7ewo2.txt' === file2bib.sh === id: cord-311176-dlwph5za author: Alshahrani, Mohammed S. title: Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus date: 2018-01-10 pages: extension: .txt txt: ./txt/cord-311176-dlwph5za.txt cache: ./cache/cord-311176-dlwph5za.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311176-dlwph5za.txt' === file2bib.sh === id: cord-311673-z4hkw17g author: Uzzan, Mathieu title: Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - lung axis hypothesis date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-311673-z4hkw17g.txt cache: ./cache/cord-311673-z4hkw17g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311673-z4hkw17g.txt' === file2bib.sh === id: cord-311752-stqrf50k author: Akbariqomi, Mostafa title: Clinical characteristics and outcome of hospitalized COVID-19 patients with diabetes: A single-center, retrospective study in Iran date: 2020-09-24 pages: extension: .txt txt: ./txt/cord-311752-stqrf50k.txt cache: ./cache/cord-311752-stqrf50k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311752-stqrf50k.txt' === file2bib.sh === id: cord-310205-j57x9ke6 author: Alcaide, Maria L. title: Pharyngitis and Epiglottitis date: 2007-06-08 pages: extension: .txt txt: ./txt/cord-310205-j57x9ke6.txt cache: ./cache/cord-310205-j57x9ke6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-310205-j57x9ke6.txt' === file2bib.sh === id: cord-312249-k7dp776s author: Srinivasan, L. title: Split ventilation with pressure regulators for patient-specific tidal volumes date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-312249-k7dp776s.txt cache: ./cache/cord-312249-k7dp776s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-312249-k7dp776s.txt' === file2bib.sh === id: cord-311682-npi03i7q author: Malicki, J title: Impact of COVID-19 on the performance of a radiation oncology department at a major comprehensive cancer centre in Poland during the first ten weeks of the epidemic date: 2020-08-16 pages: extension: .txt txt: ./txt/cord-311682-npi03i7q.txt cache: ./cache/cord-311682-npi03i7q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-311682-npi03i7q.txt' === file2bib.sh === id: cord-312199-jy3izkou author: Kraus, Kent R. title: Is There Benefit in Keeping Early Discharge Patients Overnight After Total Joint Arthroplasty? date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-312199-jy3izkou.txt cache: ./cache/cord-312199-jy3izkou.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312199-jy3izkou.txt' === file2bib.sh === id: cord-311816-j8c2lk7y author: D’Elia, Emilia title: Coronavirus Disease 2019: Where are we and Where are we Going? Intersections Between Coronavirus Disease 2019 and the Heart date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-311816-j8c2lk7y.txt cache: ./cache/cord-311816-j8c2lk7y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311816-j8c2lk7y.txt' === file2bib.sh === id: cord-311044-kjx0z1hc author: Rubio-Pérez, Inés title: COVID-19: key concepts for the surgeon date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-311044-kjx0z1hc.txt cache: ./cache/cord-311044-kjx0z1hc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311044-kjx0z1hc.txt' === file2bib.sh === id: cord-311970-o9xao5rl author: Ayerbe, Luis title: The association between treatment with heparin and survival in patients with Covid-19 date: 2020-05-31 pages: extension: .txt txt: ./txt/cord-311970-o9xao5rl.txt cache: ./cache/cord-311970-o9xao5rl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311970-o9xao5rl.txt' === file2bib.sh === id: cord-312057-4zfaqkxm author: Leppla, Idris E. title: Optimizing Medication Treatment of Opioid Use Disorder During COVID-19 (SARS-CoV-2) date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-312057-4zfaqkxm.txt cache: ./cache/cord-312057-4zfaqkxm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312057-4zfaqkxm.txt' === file2bib.sh === id: cord-311942-oju4gosw author: Grewal, Parneet title: Acute Ischemic Stroke and COVID-19: Experience From a Comprehensive Stroke Center in Midwest US date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-311942-oju4gosw.txt cache: ./cache/cord-311942-oju4gosw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311942-oju4gosw.txt' === file2bib.sh === id: cord-310177-4jw1lkli author: Simcock, R. title: Beyond Performance Status date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-310177-4jw1lkli.txt cache: ./cache/cord-310177-4jw1lkli.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-310177-4jw1lkli.txt' === file2bib.sh === id: cord-310685-gi2ycrfk author: Geiling, James title: Critical Care of the Morbidly Obese in Disaster date: 2010-10-31 pages: extension: .txt txt: ./txt/cord-310685-gi2ycrfk.txt cache: ./cache/cord-310685-gi2ycrfk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-310685-gi2ycrfk.txt' === file2bib.sh === id: cord-310663-504p29hv author: Gambardella, Jessica title: Arginine and Endothelial Function date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-310663-504p29hv.txt cache: ./cache/cord-310663-504p29hv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-310663-504p29hv.txt' === file2bib.sh === id: cord-312313-guphuppy author: Patel, Zara M title: Letter: Precautions for Endoscopic Transnasal Skull Base Surgery During the COVID-19 Pandemic date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-312313-guphuppy.txt cache: ./cache/cord-312313-guphuppy.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312313-guphuppy.txt' === file2bib.sh === id: cord-312192-hxhohtmj author: Zhu, Lan title: Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China date: 2020-04-18 pages: extension: .txt txt: ./txt/cord-312192-hxhohtmj.txt cache: ./cache/cord-312192-hxhohtmj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312192-hxhohtmj.txt' === file2bib.sh === id: cord-312609-gv1khfmo author: Fatima, Nida title: Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-312609-gv1khfmo.txt cache: ./cache/cord-312609-gv1khfmo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-312609-gv1khfmo.txt' === file2bib.sh === id: cord-312012-6a7i72bk author: Scalea, Joseph R. title: The Distancing of Surgeon From Patient in the Era of COVID-19: Bring on the Innovation date: 2020-04-13 pages: extension: .txt txt: ./txt/cord-312012-6a7i72bk.txt cache: ./cache/cord-312012-6a7i72bk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-312012-6a7i72bk.txt' === file2bib.sh === id: cord-311838-ymn96yj4 author: LIU)刘茜玮(, Qianwei title: Analysis of the Influence of the Psychology Changes of Fear Induced by the COVID-19 Epidemic on the Body date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-311838-ymn96yj4.txt cache: ./cache/cord-311838-ymn96yj4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-311838-ymn96yj4.txt' === file2bib.sh === id: cord-312846-ef7m4875 author: Nerina, Denaro title: Coronavirus Disease 19 (COVID-19) during chemoradiation for locally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC) date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-312846-ef7m4875.txt cache: ./cache/cord-312846-ef7m4875.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312846-ef7m4875.txt' === file2bib.sh === id: cord-312614-63qzissw author: Latham, Stephen R. title: Avoiding Ineffective End‐of‐Life Care: A Lesson from Triage? date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-312614-63qzissw.txt cache: ./cache/cord-312614-63qzissw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-312614-63qzissw.txt' === file2bib.sh === id: cord-312063-5c2w2ct1 author: McCollum, Lauren title: Cognitive Impairment Evaluation and Management date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-312063-5c2w2ct1.txt cache: ./cache/cord-312063-5c2w2ct1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312063-5c2w2ct1.txt' === file2bib.sh === id: cord-312033-iarl77n0 author: López Barreda, Rodrigo title: Poverty, quality of life and psychological wellbeing in adults with congenital heart disease in Chile date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-312033-iarl77n0.txt cache: ./cache/cord-312033-iarl77n0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312033-iarl77n0.txt' === file2bib.sh === id: cord-312572-i7r28wdc author: Sosnowski, Roman title: Uro-oncology in the era of social distancing: the principles of patient-centered online consultations during the COVID-19 pandemic date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-312572-i7r28wdc.txt cache: ./cache/cord-312572-i7r28wdc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-312572-i7r28wdc.txt' === file2bib.sh === id: cord-312209-3yi1w44v author: Bernstein, David N title: Transforming the Orthopaedic Patient Experience Through Telemedicine date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-312209-3yi1w44v.txt cache: ./cache/cord-312209-3yi1w44v.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-312209-3yi1w44v.txt' === file2bib.sh === id: cord-311957-3rmm1hfb author: Faes, C. title: Time between Symptom Onset, Hospitalisation and Recovery or Death: a Statistical Analysis of Different Time-Delay Distributions in Belgian COVID-19 Patients date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-311957-3rmm1hfb.txt cache: ./cache/cord-311957-3rmm1hfb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-311957-3rmm1hfb.txt' === file2bib.sh === id: cord-312065-nqy7m38f author: Peng, Philip W. H. title: Infection control and anesthesia: Lessons learned from the Toronto SARS outbreak date: 2003 pages: extension: .txt txt: ./txt/cord-312065-nqy7m38f.txt cache: ./cache/cord-312065-nqy7m38f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312065-nqy7m38f.txt' === file2bib.sh === id: cord-312795-0e4esl2o author: Puig-Domingo, M. title: COVID-19 and endocrine diseases. A statement from the European Society of Endocrinology date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-312795-0e4esl2o.txt cache: ./cache/cord-312795-0e4esl2o.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312795-0e4esl2o.txt' === file2bib.sh === id: cord-313349-ikjivfce author: Finsterer, Josef title: Causes of hypogeusia/hyposmia in SARS‐CoV2 infected patients date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-313349-ikjivfce.txt cache: ./cache/cord-313349-ikjivfce.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313349-ikjivfce.txt' === file2bib.sh === id: cord-313353-uwwih8v3 author: Di Tano, Giuseppe title: Late Pulmonary Embolism after COVID-19 Pneumonia despite Adequate Rivaroxaban Treatment date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-313353-uwwih8v3.txt cache: ./cache/cord-313353-uwwih8v3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313353-uwwih8v3.txt' === file2bib.sh === id: cord-312467-kbhljong author: Boilève, Alice title: COVID-19 management in a cancer center: the ICU storm date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-312467-kbhljong.txt cache: ./cache/cord-312467-kbhljong.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-312467-kbhljong.txt' === file2bib.sh === id: cord-313136-ab56mg6j author: Pavoni, Vittorio title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-313136-ab56mg6j.txt cache: ./cache/cord-313136-ab56mg6j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-313136-ab56mg6j.txt' === file2bib.sh === id: cord-312798-2cbgnv1h author: Varma, Niraj title: HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-312798-2cbgnv1h.txt cache: ./cache/cord-312798-2cbgnv1h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312798-2cbgnv1h.txt' === file2bib.sh === id: cord-312388-pc89ybxw author: Singhania, Namrata title: Current Overview on Hypercoagulability in COVID-19 date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-312388-pc89ybxw.txt cache: ./cache/cord-312388-pc89ybxw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312388-pc89ybxw.txt' === file2bib.sh === id: cord-312748-9v2bmbod author: Guo, Zhen title: Anticoagulation Management in Severe COVID-19 Patients on Extracorporeal Membrane Oxygenation date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-312748-9v2bmbod.txt cache: ./cache/cord-312748-9v2bmbod.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-312748-9v2bmbod.txt' === file2bib.sh === id: cord-311000-abntwzuy author: Sommer, Adir C. title: Telemedicine in ophthalmology in view of the emerging COVID-19 outbreak date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-311000-abntwzuy.txt cache: ./cache/cord-311000-abntwzuy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-311000-abntwzuy.txt' === file2bib.sh === id: cord-023364-ut56gczm author: nan title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 pages: extension: .txt txt: ./txt/cord-023364-ut56gczm.txt cache: ./cache/cord-023364-ut56gczm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-023364-ut56gczm.txt' === file2bib.sh === id: cord-313028-0nhgxoim author: Huang, Chaolin title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China date: 2020-01-24 pages: extension: .txt txt: ./txt/cord-313028-0nhgxoim.txt cache: ./cache/cord-313028-0nhgxoim.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313028-0nhgxoim.txt' === file2bib.sh === id: cord-313082-n3bo9jw1 author: Tenenbein, Paul title: The case for routine screening for SARS-CoV-2 before surgery date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-313082-n3bo9jw1.txt cache: ./cache/cord-313082-n3bo9jw1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-313082-n3bo9jw1.txt' === file2bib.sh === id: cord-312918-iof45k1r author: Ortolani, Claudio title: Hydroxychloroquine and dexamethasone in COVID-19: who won and who lost? date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-312918-iof45k1r.txt cache: ./cache/cord-312918-iof45k1r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-312918-iof45k1r.txt' === file2bib.sh === id: cord-312754-3yhxcfr2 author: Allen, Bradley D. title: Society for Cardiovascular Magnetic Resonance (SCMR) guidance for re-activation of cardiovascular magnetic resonance practice after peak phase of the COVID-19 pandemic date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-312754-3yhxcfr2.txt cache: ./cache/cord-312754-3yhxcfr2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312754-3yhxcfr2.txt' === file2bib.sh === id: cord-312212-h5j4f0xq author: Dooley, Anjali B. title: Use of Telemedicine for Sexual Medicine Patients date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-312212-h5j4f0xq.txt cache: ./cache/cord-312212-h5j4f0xq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-312212-h5j4f0xq.txt' === file2bib.sh === id: cord-313628-6610z7xk author: Igbinosa, Irogue title: Use of Remdesivir for Pregnant Patients with Severe Novel 2019 Coronavirus Disease date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-313628-6610z7xk.txt cache: ./cache/cord-313628-6610z7xk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-313628-6610z7xk.txt' === file2bib.sh === id: cord-022501-9wnmdvg5 author: nan title: P1460 – P1884 date: 2015-12-28 pages: extension: .txt txt: ./txt/cord-022501-9wnmdvg5.txt cache: ./cache/cord-022501-9wnmdvg5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-022501-9wnmdvg5.txt' === file2bib.sh === id: cord-311847-2czqs84q author: Pennisi, Manuela title: SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-311847-2czqs84q.txt cache: ./cache/cord-311847-2czqs84q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-311847-2czqs84q.txt' === file2bib.sh === id: cord-311848-8n9ee57a author: Giesen, Nicola title: Evidence-based Management of COVID-19 in Cancer Patients – Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-311848-8n9ee57a.txt cache: ./cache/cord-311848-8n9ee57a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-311848-8n9ee57a.txt' === file2bib.sh === id: cord-312684-3i2r2ahr author: Iba, Toshiaki title: Coagulopathy in COVID‐19 date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-312684-3i2r2ahr.txt cache: ./cache/cord-312684-3i2r2ahr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312684-3i2r2ahr.txt' === file2bib.sh === id: cord-312632-g4250q6l author: Cai, Xiaofang title: Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-312632-g4250q6l.txt cache: ./cache/cord-312632-g4250q6l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-312632-g4250q6l.txt' === file2bib.sh === id: cord-313494-a4pms2ub author: Sampedro, Ana Diez title: COVID-19 and Advanced Practice Registered Nurses (APRNs): Frontline update #1 date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-313494-a4pms2ub.txt cache: ./cache/cord-313494-a4pms2ub.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313494-a4pms2ub.txt' === file2bib.sh === id: cord-313836-mcm0xmzw author: Di Micco, Pierpaolo title: Venous Thromboembolism and Its Association with COVID-19: Still an Open Debate date: 2020-09-27 pages: extension: .txt txt: ./txt/cord-313836-mcm0xmzw.txt cache: ./cache/cord-313836-mcm0xmzw.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-313836-mcm0xmzw.txt' === file2bib.sh === id: cord-313728-08kwkbmd author: Binda, Barbara title: Follow-up and Management of Kidney Transplant Recipients During the COVID-19 Lockdown: the experience of an Italian Transplant Center, Including Two Cases of COVID-19 Pneumonia date: 2020-06-28 pages: extension: .txt txt: ./txt/cord-313728-08kwkbmd.txt cache: ./cache/cord-313728-08kwkbmd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313728-08kwkbmd.txt' === file2bib.sh === id: cord-314649-1y3ocvz1 author: Franks, Caroline E title: Elevated Cardiac Troponin I Is Associated with Poor Outcomes in COVID-19 Patients at an Academic Medical Center in Midwestern USA date: 2020-06-02 pages: extension: .txt txt: ./txt/cord-314649-1y3ocvz1.txt cache: ./cache/cord-314649-1y3ocvz1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-314649-1y3ocvz1.txt' === file2bib.sh === id: cord-312847-2cg3ylfl author: Carter, Chris title: COVID-19 Disease: assessment of a critically ill patient date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-312847-2cg3ylfl.txt cache: ./cache/cord-312847-2cg3ylfl.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312847-2cg3ylfl.txt' === file2bib.sh === id: cord-313529-xm76ae08 author: Liu, Wen-Kuan title: Detection of human bocavirus from children and adults with acute respiratory tract illness in Guangzhou, southern China date: 2011-12-14 pages: extension: .txt txt: ./txt/cord-313529-xm76ae08.txt cache: ./cache/cord-313529-xm76ae08.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313529-xm76ae08.txt' === file2bib.sh === id: cord-313227-6zwkfzab author: Scala, Stefania title: Fighting the Host Reaction to SARS-COv-2 in Critically Ill Patients: The Possible Contribution of Off-Label Drugs date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-313227-6zwkfzab.txt cache: ./cache/cord-313227-6zwkfzab.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313227-6zwkfzab.txt' === file2bib.sh === id: cord-313528-rp15vi1o author: Wallace, Douglas W. title: An adapted emergency department triage algorithm for the COVID‐19 pandemic date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-313528-rp15vi1o.txt cache: ./cache/cord-313528-rp15vi1o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-313528-rp15vi1o.txt' === file2bib.sh === id: cord-313239-0gl43af5 author: Moreno, Courtney C. title: CT colonography’s role in the COVID-19 pandemic: a safe(r), socially distanced total colon examination date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-313239-0gl43af5.txt cache: ./cache/cord-313239-0gl43af5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-313239-0gl43af5.txt' === file2bib.sh === id: cord-314378-cs9ggqwk author: Singh, Prateush title: The Effects of a Novel Global Pandemic (COVID-19) on a Plastic Surgery Department date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-314378-cs9ggqwk.txt cache: ./cache/cord-314378-cs9ggqwk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-314378-cs9ggqwk.txt' === file2bib.sh === id: cord-314537-8a1vqale author: Guo, Fuzheng title: An effective screening and management process in the outpatient clinic for patients requiring hospitalization during the COVID‐19 pandemic date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-314537-8a1vqale.txt cache: ./cache/cord-314537-8a1vqale.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-314537-8a1vqale.txt' === file2bib.sh === id: cord-312677-rwznqiib author: Razmi, Mahdieh title: Immunomodulatory-Based Therapy as a Potential Promising Treatment Strategy against Severe COVID-19 Patients: A Systematic Review date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-312677-rwznqiib.txt cache: ./cache/cord-312677-rwznqiib.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312677-rwznqiib.txt' === file2bib.sh === id: cord-314088-ktj17dvq author: Mancini, Francesca title: Personalized care management for persons with Parkinson's disease: A telenursing solution date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-314088-ktj17dvq.txt cache: ./cache/cord-314088-ktj17dvq.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-314088-ktj17dvq.txt' === file2bib.sh === id: cord-313785-8tipkksu author: d'Ettorre, Gabriella title: Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19 date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-313785-8tipkksu.txt cache: ./cache/cord-313785-8tipkksu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313785-8tipkksu.txt' === file2bib.sh === id: cord-314694-g0pes5o3 author: Cortiula, F. title: Managing COVID-19 in the oncology clinic and avoiding the distraction effect date: 2020-03-19 pages: extension: .txt txt: ./txt/cord-314694-g0pes5o3.txt cache: ./cache/cord-314694-g0pes5o3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-314694-g0pes5o3.txt' === file2bib.sh === id: cord-313693-qmkrn7pr author: Wong, Bonnie C. K. title: Possible Role of Aerosol Transmission in a Hospital Outbreak of Influenza date: 2010-11-15 pages: extension: .txt txt: ./txt/cord-313693-qmkrn7pr.txt cache: ./cache/cord-313693-qmkrn7pr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313693-qmkrn7pr.txt' === file2bib.sh === id: cord-313976-q5j5kr1v author: Alaarag, Ahmed title: Clinical and angiographic characteristics of patients with STEMI and confirmed diagnosis of COVID-19: an experience of Tanta University Hospital date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-313976-q5j5kr1v.txt cache: ./cache/cord-313976-q5j5kr1v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-313976-q5j5kr1v.txt' === file2bib.sh === id: cord-313118-dv5xq2k4 author: Davis, Eric M. title: Neurologic Manifestations of Systemic Disease: Sleep Disorders date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-313118-dv5xq2k4.txt cache: ./cache/cord-313118-dv5xq2k4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313118-dv5xq2k4.txt' === file2bib.sh === id: cord-314280-kf2bo06e author: Brissot, Eolia title: Management of patients with acute leukemia during the COVID-19 outbreak: practical guidelines from the acute leukemia working party of the European Society for Blood and Marrow Transplantation date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-314280-kf2bo06e.txt cache: ./cache/cord-314280-kf2bo06e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-314280-kf2bo06e.txt' === file2bib.sh === id: cord-313468-lloh1b0y author: Fernández‐Aranda, Fernando title: COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity—A collaborative international study date: 2020-09-20 pages: extension: .txt txt: ./txt/cord-313468-lloh1b0y.txt cache: ./cache/cord-313468-lloh1b0y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-313468-lloh1b0y.txt' === file2bib.sh === id: cord-313894-stgx36h5 author: Ürün, Yüksel title: Survey of the Impact of COVID-19 on Oncologists’ Decision Making in Cancer date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-313894-stgx36h5.txt cache: ./cache/cord-313894-stgx36h5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313894-stgx36h5.txt' === file2bib.sh === id: cord-314218-6znw9zcz author: Baron, D. M. title: Patient blood management during the COVID–19 pandemic: a narrative review date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-314218-6znw9zcz.txt cache: ./cache/cord-314218-6znw9zcz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-314218-6znw9zcz.txt' === file2bib.sh === id: cord-313294-ffgo56gl author: Bertsimas, D. title: Personalized Prescription of ACEI/ARBs for Hypertensive COVID-19 Patients date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-313294-ffgo56gl.txt cache: ./cache/cord-313294-ffgo56gl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313294-ffgo56gl.txt' === file2bib.sh === id: cord-315397-cm3mc7we author: Park, H. C. title: Clinical Outcome of Asymptomatic COVID-19 Infection Among a Large Nationwide Cohort of 5,621 Hospitalized Patients in Korea date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-315397-cm3mc7we.txt cache: ./cache/cord-315397-cm3mc7we.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-315397-cm3mc7we.txt' === file2bib.sh === id: cord-315311-azamwuzl author: Grattagliano, Ignazio title: The changing face of family medicine in the covid and post‐covid era date: 2020-06-07 pages: extension: .txt txt: ./txt/cord-315311-azamwuzl.txt cache: ./cache/cord-315311-azamwuzl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-315311-azamwuzl.txt' === file2bib.sh === id: cord-315116-u7btx7nt author: Cabrera-Tasayco, Fiorella del Pilar title: Biosafety Measures at the Dental Office After the Appearance of COVID-19: A Systematic Review date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-315116-u7btx7nt.txt cache: ./cache/cord-315116-u7btx7nt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315116-u7btx7nt.txt' === file2bib.sh === id: cord-313989-bc7q8swu author: Nicholls, Stephen J. title: Optimising Secondary Prevention and Cardiac Rehabilitation for Atherosclerotic Cardiovascular Disease During the COVID-19 Pandemic: A Position Statement from the Cardiac Society of Australia and New Zealand (CSANZ) # date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-313989-bc7q8swu.txt cache: ./cache/cord-313989-bc7q8swu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313989-bc7q8swu.txt' === file2bib.sh === id: cord-315569-e56c5g8h author: Aminian, Ali title: Bariatric Surgical Practice During the Initial Phase of COVID-19 Outbreak date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-315569-e56c5g8h.txt cache: ./cache/cord-315569-e56c5g8h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315569-e56c5g8h.txt' === file2bib.sh === id: cord-314152-wd153s1g author: Noor, Farha Musharrat title: Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis date: 2020-09-12 pages: extension: .txt txt: ./txt/cord-314152-wd153s1g.txt cache: ./cache/cord-314152-wd153s1g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-314152-wd153s1g.txt' === file2bib.sh === id: cord-315297-o8mwmjql author: Stephens, Elizabeth H. title: COVID-19: Crisis Management in Congenital Heart Surgery date: 2020-04-14 pages: extension: .txt txt: ./txt/cord-315297-o8mwmjql.txt cache: ./cache/cord-315297-o8mwmjql.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315297-o8mwmjql.txt' === file2bib.sh === id: cord-315486-pjb5v1tc author: Wu, Xiaojun title: Different Laboratory Abnormalities in COVID-19 Patients with Hypertension or Diabetes date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-315486-pjb5v1tc.txt cache: ./cache/cord-315486-pjb5v1tc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315486-pjb5v1tc.txt' === file2bib.sh === id: cord-315249-yclnl87n author: Read, R. C. title: Infection in acute exacerbations of chronic bronchitis: a clinical perspective date: 1999-12-31 pages: extension: .txt txt: ./txt/cord-315249-yclnl87n.txt cache: ./cache/cord-315249-yclnl87n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315249-yclnl87n.txt' === file2bib.sh === id: cord-315195-m2xqlct8 author: Alfano, Gaetano title: Peritoneal dialysis in the time of coronavirus disease 2019 date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-315195-m2xqlct8.txt cache: ./cache/cord-315195-m2xqlct8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315195-m2xqlct8.txt' === file2bib.sh === id: cord-314349-rhm1ii3d author: Kraft, Miquel title: Incidence, features, outcome and impact on health system of de-novo abdominal surgical diseases in patients admitted with COVID-19 date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-314349-rhm1ii3d.txt cache: ./cache/cord-314349-rhm1ii3d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-314349-rhm1ii3d.txt' === file2bib.sh === id: cord-314070-8qz23nn4 author: Gubbi, Sriram title: Catecholamine physiology and its implications in patients with COVID-19 date: 2020-10-28 pages: extension: .txt txt: ./txt/cord-314070-8qz23nn4.txt cache: ./cache/cord-314070-8qz23nn4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-314070-8qz23nn4.txt' === file2bib.sh === id: cord-315056-ohyb6oa0 author: Xu, Juanjuan title: Clinical characteristics and outcomes of severe or critical COVID-19 patients presenting no respiratory symptoms or fever at onset date: 2020-10-29 pages: extension: .txt txt: ./txt/cord-315056-ohyb6oa0.txt cache: ./cache/cord-315056-ohyb6oa0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-315056-ohyb6oa0.txt' === file2bib.sh === id: cord-312486-rumqopg0 author: Jacob, Chaim Oscar title: On the genetics and immunopathogenesis of COVID-19 date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-312486-rumqopg0.txt cache: ./cache/cord-312486-rumqopg0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-312486-rumqopg0.txt' === file2bib.sh === id: cord-313860-mzs3ya0s author: Giulietti, Federico title: Pharmacological Approach to Smoking Cessation: An Updated Review for Daily Clinical Practice date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-313860-mzs3ya0s.txt cache: ./cache/cord-313860-mzs3ya0s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313860-mzs3ya0s.txt' === file2bib.sh === id: cord-314826-usfvulc2 author: Sharifipour, Ehsan title: Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-314826-usfvulc2.txt cache: ./cache/cord-314826-usfvulc2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-314826-usfvulc2.txt' === file2bib.sh === id: cord-314171-431buxxr author: Dariya, Begum title: Understanding novel COVID-19: its impact on organ failure and risk assessment for diabetic and cancer patients date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-314171-431buxxr.txt cache: ./cache/cord-314171-431buxxr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-314171-431buxxr.txt' === file2bib.sh === id: cord-315188-a9pvugjt author: Choi, Min Hyuk title: Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-315188-a9pvugjt.txt cache: ./cache/cord-315188-a9pvugjt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315188-a9pvugjt.txt' === file2bib.sh === id: cord-316083-f1h2j6jx author: Alamri, Ahmad title: nan date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-316083-f1h2j6jx.txt cache: ./cache/cord-316083-f1h2j6jx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316083-f1h2j6jx.txt' === file2bib.sh === id: cord-316003-xt59voyt author: Say, Daphne S. title: Risk Stratification and Personal Protective Equipment Use in Pediatric Endoscopy During the Coronavirus Disease 2019 Outbreak: A Single-center Protocol date: 2020-03-31 pages: extension: .txt txt: ./txt/cord-316003-xt59voyt.txt cache: ./cache/cord-316003-xt59voyt.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316003-xt59voyt.txt' === file2bib.sh === id: cord-316170-ihh0pxov author: Chang, De title: Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection date: 2020-05-01 pages: extension: .txt txt: ./txt/cord-316170-ihh0pxov.txt cache: ./cache/cord-316170-ihh0pxov.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-316170-ihh0pxov.txt' === file2bib.sh === id: cord-315424-i3nnennw author: Willer, Brittany L. title: The otolaryngologist’s and anesthesiologist’s collaborative role in a pandemic: a large quaternary pediatric center’s experience with COVID-19 preparation and simulation date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-315424-i3nnennw.txt cache: ./cache/cord-315424-i3nnennw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315424-i3nnennw.txt' === file2bib.sh === id: cord-315574-jq1p5t8w author: Copland, Michael title: Canadian Society of Nephrology COVID-19 Rapid Response Team Home Dialysis Recommendations date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-315574-jq1p5t8w.txt cache: ./cache/cord-315574-jq1p5t8w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315574-jq1p5t8w.txt' === file2bib.sh === id: cord-315970-m5o962yw author: Di Ciaula, Agostino title: COVID‐19, internists and resilience: the north‐south Italy outbreak. date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-315970-m5o962yw.txt cache: ./cache/cord-315970-m5o962yw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-315970-m5o962yw.txt' === file2bib.sh === id: cord-315490-xs5v3uc3 author: Kessler, Remi A. title: Neurosurgical management of brain and spine tumors in the COVID-19 era: an institutional experience from the epicenter of the pandemic date: 2020-05-05 pages: extension: .txt txt: ./txt/cord-315490-xs5v3uc3.txt cache: ./cache/cord-315490-xs5v3uc3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-315490-xs5v3uc3.txt' === file2bib.sh === id: cord-316135-kevyw19w author: Nikoupour, Hamed title: Pediatric liver transplantation and COVID-19: a case report date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-316135-kevyw19w.txt cache: ./cache/cord-316135-kevyw19w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316135-kevyw19w.txt' === file2bib.sh === id: cord-315834-ashjw2xs author: Guo, Lingxi title: Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score date: 2019-12-03 pages: extension: .txt txt: ./txt/cord-315834-ashjw2xs.txt cache: ./cache/cord-315834-ashjw2xs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315834-ashjw2xs.txt' === file2bib.sh === id: cord-315871-anguylf1 author: Aschendorff, A. title: Quality of cochlear implant rehabilitation under COVID-19 conditions date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-315871-anguylf1.txt cache: ./cache/cord-315871-anguylf1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315871-anguylf1.txt' === file2bib.sh === id: cord-316306-vfez5k02 author: Bini, Stefano A. title: Digital Orthopaedics. A Glimpse into the Future in The Midst of a Pandemic date: 2020-04-22 pages: extension: .txt txt: ./txt/cord-316306-vfez5k02.txt cache: ./cache/cord-316306-vfez5k02.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-316306-vfez5k02.txt' === file2bib.sh === id: cord-315157-2p45frlk author: Donell, Simon T. title: Preparation for the next COVID-19 wave: The European Hip Society and European Knee Associates recommendations date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-315157-2p45frlk.txt cache: ./cache/cord-315157-2p45frlk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-315157-2p45frlk.txt' === file2bib.sh === id: cord-316673-ffkh13xm author: Andina, David title: Chilblains in children in the setting of COVID‐19 pandemic date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-316673-ffkh13xm.txt cache: ./cache/cord-316673-ffkh13xm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-316673-ffkh13xm.txt' === file2bib.sh === id: cord-023157-0lqlx2rv author: nan title: Poster Sessions date: 2013-04-18 pages: extension: .txt txt: ./txt/cord-023157-0lqlx2rv.txt cache: ./cache/cord-023157-0lqlx2rv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 25 resourceName b'cord-023157-0lqlx2rv.txt' === file2bib.sh === id: cord-316067-mlcczr8c author: Ng, Jia H. title: Outcomes of patients with end-stage kidney disease hospitalized with COVID-19 date: 2020-08-15 pages: extension: .txt txt: ./txt/cord-316067-mlcczr8c.txt cache: ./cache/cord-316067-mlcczr8c.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-316067-mlcczr8c.txt' === file2bib.sh === id: cord-316873-2gwl9m94 author: Crowley, Jerome title: Adult Extracorporeal Membrane Oxygenation Patient Selection During Coronavirus Disease 2019: The Value of a Review Panel During Coronavirus Disease 2019 date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-316873-2gwl9m94.txt cache: ./cache/cord-316873-2gwl9m94.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-316873-2gwl9m94.txt' === file2bib.sh === id: cord-317075-zegearxa author: Madenidou, Anastasia-Vasiliki title: Real-life experience of tocilizumab use in COVID-19 patients date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-317075-zegearxa.txt cache: ./cache/cord-317075-zegearxa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317075-zegearxa.txt' === file2bib.sh === id: cord-316987-3nhqx2qn author: London, Viktoriya title: Caring for Pregnant Patients with COVID-19: Practical Tips Getting from Policy to Practice date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-316987-3nhqx2qn.txt cache: ./cache/cord-316987-3nhqx2qn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316987-3nhqx2qn.txt' === file2bib.sh === id: cord-315696-43wmazxa author: Marinaki, Smaragdi title: A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-315696-43wmazxa.txt cache: ./cache/cord-315696-43wmazxa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315696-43wmazxa.txt' === file2bib.sh === id: cord-313684-61hkogdh author: Samaddar, Arghadip title: Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-313684-61hkogdh.txt cache: ./cache/cord-313684-61hkogdh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-313684-61hkogdh.txt' === file2bib.sh === id: cord-316029-z708c3ex author: Brunsdon, Priya title: Clinical Pharmacology Considerations for Developing Small‐Molecule Treatments for COVID‐19 date: 2020-07-12 pages: extension: .txt txt: ./txt/cord-316029-z708c3ex.txt cache: ./cache/cord-316029-z708c3ex.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316029-z708c3ex.txt' === file2bib.sh === id: cord-315181-emf4i6ir author: Ryoo, Nayoung title: Coping with Dementia in the Middle of the COVID-19 Pandemic date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-315181-emf4i6ir.txt cache: ./cache/cord-315181-emf4i6ir.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-315181-emf4i6ir.txt' === file2bib.sh === id: cord-316764-ps89rxuy author: Liu, Zheng title: At the center of the COVID‐19 pandemic: Lessons learned for otolaryngology‐head and neck surgery in China date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-316764-ps89rxuy.txt cache: ./cache/cord-316764-ps89rxuy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316764-ps89rxuy.txt' === file2bib.sh === id: cord-316666-qif1k62t author: Ghati, Nirmal title: Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial date: 2020-10-30 pages: extension: .txt txt: ./txt/cord-316666-qif1k62t.txt cache: ./cache/cord-316666-qif1k62t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-316666-qif1k62t.txt' === file2bib.sh === id: cord-316743-q6gbxghx author: Madhu, S. V. title: Post COVID-19 diabetes care—lessons and challenges date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-316743-q6gbxghx.txt cache: ./cache/cord-316743-q6gbxghx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316743-q6gbxghx.txt' === file2bib.sh === id: cord-316728-vyfkmniu author: Benyounes, Nadia title: Echocardiography in Confirmed and Highly Suspected Symptomatic COVID-19 Patients and Its Impact on Treatment Change date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-316728-vyfkmniu.txt cache: ./cache/cord-316728-vyfkmniu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316728-vyfkmniu.txt' === file2bib.sh === id: cord-316572-7ei96rrn author: Touska, P title: The role of transoral fine needle aspiration in expediting diagnosis and reducing risk in head and neck cancer patients in the coronavirus disease 2019 (COVID-19) era: a single-institution experience date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-316572-7ei96rrn.txt cache: ./cache/cord-316572-7ei96rrn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316572-7ei96rrn.txt' === file2bib.sh === id: cord-314106-r3axl3w1 author: Porembskaya, Olga title: Pulmonary Artery Thrombosis: A Diagnosis That Strives for Its Independence date: 2020-07-18 pages: extension: .txt txt: ./txt/cord-314106-r3axl3w1.txt cache: ./cache/cord-314106-r3axl3w1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-314106-r3axl3w1.txt' === file2bib.sh === id: cord-316137-6zdxfv8v author: Wang, Yuanyuan title: Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching date: 2020-11-05 pages: extension: .txt txt: ./txt/cord-316137-6zdxfv8v.txt cache: ./cache/cord-316137-6zdxfv8v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316137-6zdxfv8v.txt' === file2bib.sh === id: cord-316376-76beuk0c author: Medeiros, Augusto Kreling title: Higher frequency of hepatic steatosis at CT among COVID-19-positive patients date: 2020-07-18 pages: extension: .txt txt: ./txt/cord-316376-76beuk0c.txt cache: ./cache/cord-316376-76beuk0c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316376-76beuk0c.txt' === file2bib.sh === id: cord-314449-ukqux772 author: Curtis, L.T. title: Prevention of hospital-acquired infections: review of non-pharmacological interventions date: 2008-06-02 pages: extension: .txt txt: ./txt/cord-314449-ukqux772.txt cache: ./cache/cord-314449-ukqux772.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-314449-ukqux772.txt' === file2bib.sh === id: cord-316845-k9zvsfvj author: Robertson, Mary M. title: Gilles de la Tourette Syndrome: advice in the times of COVID-19 date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-316845-k9zvsfvj.txt cache: ./cache/cord-316845-k9zvsfvj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316845-k9zvsfvj.txt' === file2bib.sh === id: cord-317809-umb8j63t author: Salari, Abolfazl title: COVID-19 pandemic & head and neck cancer patients management: The role of virtual multidisciplinary team meetings date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-317809-umb8j63t.txt cache: ./cache/cord-317809-umb8j63t.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317809-umb8j63t.txt' === file2bib.sh === id: cord-316118-ph582weg author: Frajkova, Zofia title: Postintubation Dysphagia During COVID-19 Outbreak-Contemporary Review date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-316118-ph582weg.txt cache: ./cache/cord-316118-ph582weg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316118-ph582weg.txt' === file2bib.sh === id: cord-316522-fbw9x3ik author: Reiss, Allison B. title: A Telemedicine Approach to Covid-19 Assessment and Triage date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-316522-fbw9x3ik.txt cache: ./cache/cord-316522-fbw9x3ik.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316522-fbw9x3ik.txt' === file2bib.sh === id: cord-316370-t802kjpk author: Szperka, Christina L. title: Migraine Care in the Era of COVID‐19: Clinical Pearls and Plea to Insurers date: 2020-04-03 pages: extension: .txt txt: ./txt/cord-316370-t802kjpk.txt cache: ./cache/cord-316370-t802kjpk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316370-t802kjpk.txt' === file2bib.sh === id: cord-316432-xemz7zn9 author: Talaie, Haleh title: Is there any potential management against COVID-19? A systematic review and meta-analysis date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-316432-xemz7zn9.txt cache: ./cache/cord-316432-xemz7zn9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316432-xemz7zn9.txt' === file2bib.sh === id: cord-316938-64jxtg9y author: Blasi, Annabel title: In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-316938-64jxtg9y.txt cache: ./cache/cord-316938-64jxtg9y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316938-64jxtg9y.txt' === file2bib.sh === id: cord-317242-e7000i2u author: Gandhi, Darshan title: Review of X-ray and computed tomography scan findings with a promising role of point of care ultrasound in COVID-19 pandemic date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-317242-e7000i2u.txt cache: ./cache/cord-317242-e7000i2u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317242-e7000i2u.txt' === file2bib.sh === id: cord-316117-o29773cz author: Menzella, Francesco title: Pharmacologicaltreatment of COVID-19: lights and shadows date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-316117-o29773cz.txt cache: ./cache/cord-316117-o29773cz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-316117-o29773cz.txt' === file2bib.sh === id: cord-316095-jzyb4jn5 author: Falahchai, Mehran title: Dental care management during the COVID‐19 outbreak date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-316095-jzyb4jn5.txt cache: ./cache/cord-316095-jzyb4jn5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316095-jzyb4jn5.txt' === file2bib.sh === id: cord-317535-zep5axfo author: Azpiazu Landa, N. title: Ischemic-hemorrhagic stroke in patients with Covid-19 date: 2020-11-07 pages: extension: .txt txt: ./txt/cord-317535-zep5axfo.txt cache: ./cache/cord-317535-zep5axfo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317535-zep5axfo.txt' === file2bib.sh === id: cord-317265-n6x0r58i author: Singh, Varsha title: Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease? date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-317265-n6x0r58i.txt cache: ./cache/cord-317265-n6x0r58i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317265-n6x0r58i.txt' === file2bib.sh === id: cord-316835-qf0c91vr author: McLeod, Jacob M. title: Nontraumatic Osteonecrosis of the Distal Tibia: A Case Presentation and Review of the Literature date: 2016-08-18 pages: extension: .txt txt: ./txt/cord-316835-qf0c91vr.txt cache: ./cache/cord-316835-qf0c91vr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-316835-qf0c91vr.txt' === file2bib.sh === id: cord-015021-pol2qm74 author: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 pages: extension: .txt txt: ./txt/cord-015021-pol2qm74.txt cache: ./cache/cord-015021-pol2qm74.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-015021-pol2qm74.txt' === file2bib.sh === id: cord-317604-j8b64a1a author: Sahay, Sandeep title: Management of hospitalized patients with pulmonary arterial hypertension and COVID-19 infection date: 2020-06-15 pages: extension: .txt txt: ./txt/cord-317604-j8b64a1a.txt cache: ./cache/cord-317604-j8b64a1a.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317604-j8b64a1a.txt' === file2bib.sh === id: cord-317468-pnxni1x5 author: Louie, Philip K. title: Early Peri-operative Outcomes Were Unchanged in Patients Undergoing Spine Surgery During the COVID-19 Pandemic in New York City date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-317468-pnxni1x5.txt cache: ./cache/cord-317468-pnxni1x5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317468-pnxni1x5.txt' === file2bib.sh === id: cord-317918-pl625ela author: Ripa, Marco title: Secondary Infections in Patients Hospitalized with COVID-19: Incidence and Predictive Factors date: 2020-10-24 pages: extension: .txt txt: ./txt/cord-317918-pl625ela.txt cache: ./cache/cord-317918-pl625ela.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317918-pl625ela.txt' === file2bib.sh === id: cord-316616-j82q99in author: Su, Yen-Bo title: Cardiovascular manifestation and treatment in COVID-19 date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-316616-j82q99in.txt cache: ./cache/cord-316616-j82q99in.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-316616-j82q99in.txt' === file2bib.sh === id: cord-317575-srg9cyqp author: Chien, Chen‐Yu title: Proactive measures for the pandemic COVID‐19 infection in outpatient clinics of Otolaryngology Department date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-317575-srg9cyqp.txt cache: ./cache/cord-317575-srg9cyqp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317575-srg9cyqp.txt' === file2bib.sh === id: cord-317811-mxsujb5u author: Migliaccio, Raffaella title: Dementia and COVID-19 Lockdown: More Than a Double Blow for Patients and Caregivers date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-317811-mxsujb5u.txt cache: ./cache/cord-317811-mxsujb5u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317811-mxsujb5u.txt' === file2bib.sh === id: cord-318167-b25g6zkp author: Einollahi, Behzad title: A patient affected by critical COVID-19 pneumonia, successfully treated with convalescent plasma date: 2020-11-05 pages: extension: .txt txt: ./txt/cord-318167-b25g6zkp.txt cache: ./cache/cord-318167-b25g6zkp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318167-b25g6zkp.txt' === file2bib.sh === id: cord-318311-aakpbbvl author: Du, Na title: The experience of prevention measures taken by the psychiatric hospital during the emergence of asymptomatic patients with COVID-19 date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-318311-aakpbbvl.txt cache: ./cache/cord-318311-aakpbbvl.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318311-aakpbbvl.txt' === file2bib.sh === id: cord-317151-cxx5pcln author: Papa, Alfredo title: Covid-19 and the management of patients with inflammatory bowel disease: a practical decalogue for the post-pandemic phase date: 2020-10-24 pages: extension: .txt txt: ./txt/cord-317151-cxx5pcln.txt cache: ./cache/cord-317151-cxx5pcln.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317151-cxx5pcln.txt' === file2bib.sh === id: cord-315149-71bmj5il author: Caballero Bermejo, Antonio F. title: Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-315149-71bmj5il.txt cache: ./cache/cord-315149-71bmj5il.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315149-71bmj5il.txt' === file2bib.sh === id: cord-317028-f3bpwm5j author: Olmsted, Russell N. title: Prevention by Design: Construction and Renovation of Health Care Facilities for Patient Safety and Infection Prevention date: 2016-08-09 pages: extension: .txt txt: ./txt/cord-317028-f3bpwm5j.txt cache: ./cache/cord-317028-f3bpwm5j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317028-f3bpwm5j.txt' === file2bib.sh === id: cord-317932-5sqj2klm author: Stevens, Jacob S. title: Dashboards to facilitate nephrology disaster planning in the COVID-19 era date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-317932-5sqj2klm.txt cache: ./cache/cord-317932-5sqj2klm.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317932-5sqj2klm.txt' === file2bib.sh === id: cord-317085-qc8bfb9g author: Zhang, Nan title: Risk Factors for Poor Outcomes of Diabetes Patients With COVID-19: A Single-Center, Retrospective Study in Early Outbreak in China date: 2020-09-24 pages: extension: .txt txt: ./txt/cord-317085-qc8bfb9g.txt cache: ./cache/cord-317085-qc8bfb9g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-317085-qc8bfb9g.txt' === file2bib.sh === id: cord-317966-ut6tzc8s author: Kocak, Burak title: A Case Report of Oligosymptomatic Kidney Transplant Patients with COVID-19: Do They Pose a Risk to Other Recipients? date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-317966-ut6tzc8s.txt cache: ./cache/cord-317966-ut6tzc8s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317966-ut6tzc8s.txt' === file2bib.sh === id: cord-317566-6ch6na31 author: Epstein, Robert S. title: Patient Burden and Real-World Management of Chemotherapy-Induced Myelosuppression: Results from an Online Survey of Patients with Solid Tumors date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-317566-6ch6na31.txt cache: ./cache/cord-317566-6ch6na31.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317566-6ch6na31.txt' === file2bib.sh === id: cord-318094-losjbgn6 author: Alan, Nima title: Inter-facility transfer of patients with traumatic intracranial hemorrhage and GCS 14–15: The pilot study of a screening protocol by neurosurgeon to avoid unnecessary transfers date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-318094-losjbgn6.txt cache: ./cache/cord-318094-losjbgn6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318094-losjbgn6.txt' === file2bib.sh === id: cord-318694-370ccaoc author: Khanna, Niharika title: Utilizing the Learning Health System Adaptation to guide Family Medicine Practice to COVID-19 response date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-318694-370ccaoc.txt cache: ./cache/cord-318694-370ccaoc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318694-370ccaoc.txt' === file2bib.sh === id: cord-318355-38x3f3ee author: Yang, Yang title: Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with Sars‐COV‐2 date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-318355-38x3f3ee.txt cache: ./cache/cord-318355-38x3f3ee.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-318355-38x3f3ee.txt' === file2bib.sh === id: cord-318021-4qrf5m8s author: Wolfensberger, A. title: Development and validation of a semi-automated surveillance system—lowering the fruit for non-ventilator-associated hospital-acquired pneumonia (nvHAP) prevention() date: 2019-03-25 pages: extension: .txt txt: ./txt/cord-318021-4qrf5m8s.txt cache: ./cache/cord-318021-4qrf5m8s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-318021-4qrf5m8s.txt' === file2bib.sh === id: cord-317689-gp4x54pe author: Galanopoulou, Aristea S. title: EEG findings in acutely ill patients investigated for SARS‐CoV‐2/COVID‐19: A small case series preliminary report date: 2020-05-17 pages: extension: .txt txt: ./txt/cord-317689-gp4x54pe.txt cache: ./cache/cord-317689-gp4x54pe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-317689-gp4x54pe.txt' === file2bib.sh === id: cord-318312-v1c3qm7h author: Fischer, Quentin title: Case report of anterior ST-elevation myocardial infarction in a patient with coronavirus disease-2019 date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-318312-v1c3qm7h.txt cache: ./cache/cord-318312-v1c3qm7h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318312-v1c3qm7h.txt' === file2bib.sh === id: cord-315730-fzgxuak7 author: Penman, Sophie L. title: Safety perspectives on presently considered drugs for the treatment of COVID‐19 date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-315730-fzgxuak7.txt cache: ./cache/cord-315730-fzgxuak7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-315730-fzgxuak7.txt' === file2bib.sh === id: cord-318909-h5b7mncf author: Liguori, Claudio title: Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-318909-h5b7mncf.txt cache: ./cache/cord-318909-h5b7mncf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318909-h5b7mncf.txt' === file2bib.sh === id: cord-318369-y3wtfqrn author: Pan, Lingai title: How to optimize the Radiology protocol during the global COVID-19 epidemic: Keypoints from Sichuan Provincial People's Hospital date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-318369-y3wtfqrn.txt cache: ./cache/cord-318369-y3wtfqrn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-318369-y3wtfqrn.txt' === file2bib.sh === id: cord-318333-rzhrgp5q author: Hou, Jiabao title: COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-318333-rzhrgp5q.txt cache: ./cache/cord-318333-rzhrgp5q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-318333-rzhrgp5q.txt' === file2bib.sh === id: cord-319218-mejvlkfg author: Marandino, Laura title: The Shifting Landscape of Genitourinary Oncology During the COVID-19 Pandemic and how Italian Oncologists Reacted: Results from a National Survey date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-319218-mejvlkfg.txt cache: ./cache/cord-319218-mejvlkfg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-319218-mejvlkfg.txt' === file2bib.sh === id: cord-318954-pj5lsvsa author: Arabi, Yaseen title: Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol date: 2015-11-19 pages: extension: .txt txt: ./txt/cord-318954-pj5lsvsa.txt cache: ./cache/cord-318954-pj5lsvsa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318954-pj5lsvsa.txt' === file2bib.sh === id: cord-318520-hgjv7ot9 author: Mohamed, Sherif title: Death due to Cardiac Arrest in a Young Female With Highly Suspected COVID-19: A Case Report date: 2020-08-30 pages: extension: .txt txt: ./txt/cord-318520-hgjv7ot9.txt cache: ./cache/cord-318520-hgjv7ot9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-318520-hgjv7ot9.txt' === file2bib.sh === id: cord-318808-1cfwj5uq author: Li, Ying title: Comparison of Hospitalized Patients with pneumonia caused by COVID-19 and influenza A in children under 5 years date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-318808-1cfwj5uq.txt cache: ./cache/cord-318808-1cfwj5uq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318808-1cfwj5uq.txt' === file2bib.sh === id: cord-318326-q9fnbg8n author: Cacciapuoti, Sara title: Immunocytometric analysis of COVID patients: A contribution to personalized therapy? date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-318326-q9fnbg8n.txt cache: ./cache/cord-318326-q9fnbg8n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318326-q9fnbg8n.txt' === file2bib.sh === id: cord-318229-29cgwivt author: Baier, Claas title: Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease date: 2018-02-13 pages: extension: .txt txt: ./txt/cord-318229-29cgwivt.txt cache: ./cache/cord-318229-29cgwivt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-318229-29cgwivt.txt' === file2bib.sh === id: cord-320634-x7a3k5xu author: Salna, Michael title: Reply: A problem of “ethic” proportions date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-320634-x7a3k5xu.txt cache: ./cache/cord-320634-x7a3k5xu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-320634-x7a3k5xu.txt' === file2bib.sh === id: cord-320599-hxn4bgec author: Liontos, Michalis title: Chemotherapy resumption in ovarian cancer patient diagnosed with COVID-19 date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-320599-hxn4bgec.txt cache: ./cache/cord-320599-hxn4bgec.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-320599-hxn4bgec.txt' === file2bib.sh === id: cord-319615-p2labgd8 author: Schulman, Sam title: Coronavirus Disease 2019, Prothrombotic Factors, and Venous Thromboembolism date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-319615-p2labgd8.txt cache: ./cache/cord-319615-p2labgd8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-319615-p2labgd8.txt' === file2bib.sh === id: cord-319400-lghjiw5p author: Chaix, B. title: Psychological Distress during the COVID-19 pandemic in France: a national assessment of at-risk populations date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-319400-lghjiw5p.txt cache: ./cache/cord-319400-lghjiw5p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-319400-lghjiw5p.txt' === file2bib.sh === id: cord-319333-jwbgytwd author: Radmard, Sara title: Inpatient Neurology Consultations During the Onset of the SARS-CoV-2 New York City Pandemic: A Single Center Case Series date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-319333-jwbgytwd.txt cache: ./cache/cord-319333-jwbgytwd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-319333-jwbgytwd.txt' === file2bib.sh === id: cord-319849-3shr5grg author: Cheruiyot, Isaac title: Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients date: 2020-11-03 pages: extension: .txt txt: ./txt/cord-319849-3shr5grg.txt cache: ./cache/cord-319849-3shr5grg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-319849-3shr5grg.txt' === file2bib.sh === id: cord-318873-zwot69s3 author: Braunstein, Eric D. title: Inpatient Cardiac Monitoring Using a Patch‐Based Mobile Cardiac Telemetry System During the COVID‐19 Pandemic date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-318873-zwot69s3.txt cache: ./cache/cord-318873-zwot69s3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-318873-zwot69s3.txt' === file2bib.sh === id: cord-320477-zbp8a8dr author: Fung, Timothy H.M. title: Addressing COVID‐19 fear to improve clinic attendance for patients with wet age‐related macular degeneration date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-320477-zbp8a8dr.txt cache: ./cache/cord-320477-zbp8a8dr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-320477-zbp8a8dr.txt' === file2bib.sh === id: cord-318830-a3n4c5d1 author: Brook, Olga R. title: Feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-318830-a3n4c5d1.txt cache: ./cache/cord-318830-a3n4c5d1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-318830-a3n4c5d1.txt' === file2bib.sh === id: cord-318262-w8oixzdg author: Chevance, A title: Ensuring mental health care during the SARS-CoV-2 epidemic in France: a narrative review date: 2020-04-22 pages: extension: .txt txt: ./txt/cord-318262-w8oixzdg.txt cache: ./cache/cord-318262-w8oixzdg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-318262-w8oixzdg.txt' === file2bib.sh === id: cord-321064-pe8466n1 author: Saraceni, Francesco title: Severe COVID‐19 in a patient with chronic graft‐versus‐host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-321064-pe8466n1.txt cache: ./cache/cord-321064-pe8466n1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321064-pe8466n1.txt' === file2bib.sh === id: cord-319742-ypkt01rn author: Asgharpour, Masoumeh title: Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19) date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-319742-ypkt01rn.txt cache: ./cache/cord-319742-ypkt01rn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-319742-ypkt01rn.txt' === file2bib.sh === id: cord-320445-pdvkyzci author: Fry, Alicia M. title: Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand date: 2007-04-01 pages: extension: .txt txt: ./txt/cord-320445-pdvkyzci.txt cache: ./cache/cord-320445-pdvkyzci.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320445-pdvkyzci.txt' === file2bib.sh === id: cord-319930-ymqnb54a author: Kremer, Stéphane title: Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-319930-ymqnb54a.txt cache: ./cache/cord-319930-ymqnb54a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-319930-ymqnb54a.txt' === file2bib.sh === id: cord-316647-jj8anf5g author: Shang, You title: Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China date: 2020-06-06 pages: extension: .txt txt: ./txt/cord-316647-jj8anf5g.txt cache: ./cache/cord-316647-jj8anf5g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-316647-jj8anf5g.txt' === file2bib.sh === id: cord-320892-dcfi5u04 author: Kaidi, Austin C. title: Timing and Tips for Total Hip Arthroplasty in a Critically Ill COVID-19 Patient with a Femoral Neck Fracture: A Case Report date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-320892-dcfi5u04.txt cache: ./cache/cord-320892-dcfi5u04.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-320892-dcfi5u04.txt' === file2bib.sh === id: cord-320612-vam0bli3 author: Höring, Steffen title: Management of a Hospital-Wide COVID-19 Outbreak Affecting Patients and Healthcare Workers date: 2020-10-26 pages: extension: .txt txt: ./txt/cord-320612-vam0bli3.txt cache: ./cache/cord-320612-vam0bli3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320612-vam0bli3.txt' === file2bib.sh === id: cord-318063-bainw3d6 author: Haque, Mainul title: Health care-associated infections – an overview date: 2018-11-15 pages: extension: .txt txt: ./txt/cord-318063-bainw3d6.txt cache: ./cache/cord-318063-bainw3d6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318063-bainw3d6.txt' === file2bib.sh === id: cord-319567-4t5t8bcx author: Şentürk, Mert title: Thoracic Anesthesia of Patients with Suspected or Confirmed 2019 Novel Coronavirus Infection: Preliminary Recommendations for Airway Management by the EACTA Thoracic Subspecialty Committee date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-319567-4t5t8bcx.txt cache: ./cache/cord-319567-4t5t8bcx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-319567-4t5t8bcx.txt' === file2bib.sh === id: cord-318282-ocgfgx9r author: Boyce, John M title: Meticillin-resistant Staphylococcus aureus date: 2005-10-31 pages: extension: .txt txt: ./txt/cord-318282-ocgfgx9r.txt cache: ./cache/cord-318282-ocgfgx9r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318282-ocgfgx9r.txt' === file2bib.sh === id: cord-320349-6hbuq0k7 author: Zhou, Hua title: Development of early warning and rapid response system for patients with novel coronavirus pneumonia (COVID-19): A research protocol date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-320349-6hbuq0k7.txt cache: ./cache/cord-320349-6hbuq0k7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320349-6hbuq0k7.txt' === file2bib.sh === id: cord-320811-9sm7iz5x author: Harkin, Denis W. title: Ethics for surgeons during the COVID-19 pandemic, review article date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-320811-9sm7iz5x.txt cache: ./cache/cord-320811-9sm7iz5x.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320811-9sm7iz5x.txt' === file2bib.sh === id: cord-320267-n21jryi2 author: AlShoaibi, Naeem A. title: Saudi Heart Rhythm Society Task Force on Management of Potential Arrhythmogenicity Associated with Pharmacotherapy for COVID-19 date: 2020-09-20 pages: extension: .txt txt: ./txt/cord-320267-n21jryi2.txt cache: ./cache/cord-320267-n21jryi2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320267-n21jryi2.txt' === file2bib.sh === id: cord-320788-ln8ddyuj author: Wang, Chun-Hua title: Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS date: 2005-05-11 pages: extension: .txt txt: ./txt/cord-320788-ln8ddyuj.txt cache: ./cache/cord-320788-ln8ddyuj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320788-ln8ddyuj.txt' === file2bib.sh === id: cord-320149-3q4q98a6 author: Di Carlo, Davide Tiziano title: Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature date: 2020-08-01 pages: extension: .txt txt: ./txt/cord-320149-3q4q98a6.txt cache: ./cache/cord-320149-3q4q98a6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320149-3q4q98a6.txt' === file2bib.sh === id: cord-320877-1i0hzfjk author: KIYKAÇ ALTINBAŞ, Şadıman title: Gynecological laparoscopic surgery in the shade of COVID-19 pandemic date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-320877-1i0hzfjk.txt cache: ./cache/cord-320877-1i0hzfjk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-320877-1i0hzfjk.txt' === file2bib.sh === id: cord-320572-94fvtj4a author: Wendel Garcia, Pedro David title: Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-320572-94fvtj4a.txt cache: ./cache/cord-320572-94fvtj4a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320572-94fvtj4a.txt' === file2bib.sh === id: cord-319805-b6ypt5d0 author: Siepmann, Timo title: Association of history of cerebrovascular disease with severity of COVID-19 date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-319805-b6ypt5d0.txt cache: ./cache/cord-319805-b6ypt5d0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-319805-b6ypt5d0.txt' === file2bib.sh === id: cord-319037-77l9wdyb author: Gavriilaki, Eleni title: A New Era in Endothelial Injury Syndromes: Toxicity of CAR-T Cells and the Role of Immunity date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-319037-77l9wdyb.txt cache: ./cache/cord-319037-77l9wdyb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-319037-77l9wdyb.txt' === file2bib.sh === id: cord-319823-sp5wibeh author: Brown, Sherry-Ann title: Innovation in Precision Cardio-Oncology During the Coronavirus Pandemic and Into a Post-pandemic World date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-319823-sp5wibeh.txt cache: ./cache/cord-319823-sp5wibeh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-319823-sp5wibeh.txt' === file2bib.sh === id: cord-320695-gq7k331z author: Sairras, Shellice title: Heart Failure Hospitalizations and Risk Factors among the Multi-Ethnic Population from a Middle Income Country: The Suriname Heart Failure Studies date: 2020-09-11 pages: extension: .txt txt: ./txt/cord-320695-gq7k331z.txt cache: ./cache/cord-320695-gq7k331z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-320695-gq7k331z.txt' === file2bib.sh === id: cord-321346-epsp3bbm author: Luppa, Peter B. title: Point-of-care testing (POCT): Current techniques and future perspectives date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-321346-epsp3bbm.txt cache: ./cache/cord-321346-epsp3bbm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-321346-epsp3bbm.txt' === file2bib.sh === id: cord-321768-oevswvvd author: Duan, Ya-qi title: Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-321768-oevswvvd.txt cache: ./cache/cord-321768-oevswvvd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321768-oevswvvd.txt' === file2bib.sh === id: cord-321748-9a54ekac author: Kim, Sang Il title: Walk-Through Screening Center for COVID-19: an Accessible and Efficient Screening System in a Pandemic Situation date: 2020-04-14 pages: extension: .txt txt: ./txt/cord-321748-9a54ekac.txt cache: ./cache/cord-321748-9a54ekac.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-321748-9a54ekac.txt' === file2bib.sh === id: cord-320864-k9zksbyt author: Remes-Troche, J. M. title: Recommendations for the reopening and activity resumption of the neurogastroenterology units in the face of the COVID-19 pandemic. Position of the Sociedad Latinoamericana de Neurogastroenterología date: 2020-11-01 pages: extension: .txt txt: ./txt/cord-320864-k9zksbyt.txt cache: ./cache/cord-320864-k9zksbyt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-320864-k9zksbyt.txt' === file2bib.sh === id: cord-319706-2e9jrv0s author: Ebinger, Joseph E. title: Pre-existing traits associated with Covid-19 illness severity date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-319706-2e9jrv0s.txt cache: ./cache/cord-319706-2e9jrv0s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-319706-2e9jrv0s.txt' === file2bib.sh === id: cord-321461-1s3y9kc5 author: Rajdev, Kartikeya title: Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting Evidence date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-321461-1s3y9kc5.txt cache: ./cache/cord-321461-1s3y9kc5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321461-1s3y9kc5.txt' === file2bib.sh === id: cord-319013-oytqcifa author: Focosi, Daniele title: Convalescent Plasma Therapy for COVID-19: State of the Art date: 2020-08-12 pages: extension: .txt txt: ./txt/cord-319013-oytqcifa.txt cache: ./cache/cord-319013-oytqcifa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-319013-oytqcifa.txt' === file2bib.sh === id: cord-321543-qdmvn44h author: Webb, J. B. title: Computational Simulation to Assess Patient Safety of Uncompensated COVID-19 Two-patient Ventilator Sharing Using the Pulse Physiology Engine date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-321543-qdmvn44h.txt cache: ./cache/cord-321543-qdmvn44h.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321543-qdmvn44h.txt' === file2bib.sh === id: cord-321311-v2i1caug author: Weller, Michael title: How we treat patients with brain tumour during the COVID-19 pandemic date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-321311-v2i1caug.txt cache: ./cache/cord-321311-v2i1caug.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321311-v2i1caug.txt' === file2bib.sh === id: cord-320831-owfnttqr author: Klimek, Ludger title: Allergen immunotherapy in the current COVID-19 pandemic: A position paper of AeDA, ARIA, EAACI, DGAKI and GPA: Position paper of the German ARIA Group(A) in cooperation with the Austrian ARIA Group(B), the Swiss ARIA Group(C), German Society for Applied Allergology (AEDA)(D), German Society for Allergology and Clinical Immunology (DGAKI)(E), Society for Pediatric Allergology (GPA)(F) in cooperation with AG Clinical Immunology, Allergology and Environmental Medicine of the DGHNO-KHC(G) and the European Academy of Allergy and Clinical Immunology (EAACI)(H) date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-320831-owfnttqr.txt cache: ./cache/cord-320831-owfnttqr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-320831-owfnttqr.txt' === file2bib.sh === id: cord-318944-13zk6cco author: Bizzoca, Maria Eleonora title: Covid-19 Pandemic: What Changes for Dentists and Oral Medicine Experts? A Narrative Review and Novel Approaches to Infection Containment date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-318944-13zk6cco.txt cache: ./cache/cord-318944-13zk6cco.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318944-13zk6cco.txt' === file2bib.sh === id: cord-321149-hffj7s4o author: Schmidt, Matthieu title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-321149-hffj7s4o.txt cache: ./cache/cord-321149-hffj7s4o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321149-hffj7s4o.txt' === file2bib.sh === id: cord-320632-369kax2m author: Song, Yang title: COVID-19 Treatment: Close to a Cure? – A Rapid Review of Pharmacotherapies for the Novel Coronavirus date: 2020-07-04 pages: extension: .txt txt: ./txt/cord-320632-369kax2m.txt cache: ./cache/cord-320632-369kax2m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320632-369kax2m.txt' === file2bib.sh === id: cord-321788-z2y1ywdq author: Dong, J. title: Chest CT Scan of Hospitalized Patients with COVID-19: A Case-Control Study date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-321788-z2y1ywdq.txt cache: ./cache/cord-321788-z2y1ywdq.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-321788-z2y1ywdq.txt' === file2bib.sh === id: cord-317952-4oa9hfb4 author: Bourgonje, Arno R. title: Angiotensin‐converting enzyme‐2 (ACE2), SARS‐CoV‐2 and pathophysiology of coronavirus disease 2019 (COVID‐19) date: 2020-05-17 pages: extension: .txt txt: ./txt/cord-317952-4oa9hfb4.txt cache: ./cache/cord-317952-4oa9hfb4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317952-4oa9hfb4.txt' === file2bib.sh === id: cord-321030-isc3p46t author: Rodriguez Socarrás, Moises title: Telemedicine and Smart Working: Recommendations of the European Association of Urology date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-321030-isc3p46t.txt cache: ./cache/cord-321030-isc3p46t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-321030-isc3p46t.txt' === file2bib.sh === id: cord-321651-7e8dwcur author: Jazieh, Abdul-Rahman title: Managing Oncology Services During a Major Coronavirus Outbreak: Lessons From the Saudi Arabia Experience date: 2020-03-27 pages: extension: .txt txt: ./txt/cord-321651-7e8dwcur.txt cache: ./cache/cord-321651-7e8dwcur.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-321651-7e8dwcur.txt' === file2bib.sh === id: cord-321983-566pbuic author: Liu, Wei title: Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease date: 2020-02-28 pages: extension: .txt txt: ./txt/cord-321983-566pbuic.txt cache: ./cache/cord-321983-566pbuic.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-321983-566pbuic.txt' === file2bib.sh === id: cord-322066-m8dphaml author: Kutscher, Eric title: Primary Care Providers: Discuss COVID-19-Related Goals of Care with Your Vulnerable Patients Now date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-322066-m8dphaml.txt cache: ./cache/cord-322066-m8dphaml.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-322066-m8dphaml.txt' === file2bib.sh === id: cord-321594-x5wv9p7n author: Jiang, Wen title: Equal Access to Telemedicine during COVID‐19 Pandemic: A Pediatric Otolaryngology Perspective date: 2020-10-05 pages: extension: .txt txt: ./txt/cord-321594-x5wv9p7n.txt cache: ./cache/cord-321594-x5wv9p7n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-321594-x5wv9p7n.txt' === file2bib.sh === id: cord-320184-wacoz5t9 author: Thirumalaikolundusubramanian, Ponniah title: Ethics, Legality, and Education in the Practice of Cardiology date: 2014-08-15 pages: extension: .txt txt: ./txt/cord-320184-wacoz5t9.txt cache: ./cache/cord-320184-wacoz5t9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-320184-wacoz5t9.txt' === file2bib.sh === id: cord-321237-ynhdii60 author: Shahroor, S. H. title: Adaptive split ventilator system enables parallel ventilation, individual monitoring and ventilation pressures control for each lung simulators date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-321237-ynhdii60.txt cache: ./cache/cord-321237-ynhdii60.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-321237-ynhdii60.txt' === file2bib.sh === id: cord-322063-96suqyfg author: Kampmeier, Stefanie title: A nosocomial cluster of vancomycin resistant enterococci among COVID-19 patients in an intensive care unit date: 2020-09-22 pages: extension: .txt txt: ./txt/cord-322063-96suqyfg.txt cache: ./cache/cord-322063-96suqyfg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-322063-96suqyfg.txt' === file2bib.sh === id: cord-320930-9yiu0080 author: Liu, Zeming title: Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-320930-9yiu0080.txt cache: ./cache/cord-320930-9yiu0080.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-320930-9yiu0080.txt' === file2bib.sh === id: cord-321801-w66v5kzh author: Grabala, Jolanta title: Possibilities of using ultrasound for diagnosis of invasive pulmonary mucormycosis – A case study date: 2017-08-31 pages: extension: .txt txt: ./txt/cord-321801-w66v5kzh.txt cache: ./cache/cord-321801-w66v5kzh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321801-w66v5kzh.txt' === file2bib.sh === id: cord-322052-zsbisk3b author: Bohórquez-Rivero, José title: Letter to the Editor: Humanization of Neurosurgery: Incorporation of a New Concept in Times of COVID-19 date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-322052-zsbisk3b.txt cache: ./cache/cord-322052-zsbisk3b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-322052-zsbisk3b.txt' === file2bib.sh === id: cord-322439-86dojc70 author: Celarier, Thomas title: Covid-19: Adapting the geriatric organisations to respond to the pandemic date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-322439-86dojc70.txt cache: ./cache/cord-322439-86dojc70.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-322439-86dojc70.txt' === file2bib.sh === id: cord-322054-whjisspt author: Zhang, S. title: Concerns about disease management and psychological stress in SAPHO patients during the COVID-19 epidemic date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-322054-whjisspt.txt cache: ./cache/cord-322054-whjisspt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322054-whjisspt.txt' === file2bib.sh === id: cord-322259-khknne8s author: de Roquetaillade, C. title: Unusual arterial thrombotic events in Covid-19 patients date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-322259-khknne8s.txt cache: ./cache/cord-322259-khknne8s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322259-khknne8s.txt' === file2bib.sh === id: cord-322534-eikz07zz author: Allahyari, Abolghasem title: Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structured summary of a study protocol for a randomised controlled trial date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-322534-eikz07zz.txt cache: ./cache/cord-322534-eikz07zz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-322534-eikz07zz.txt' === file2bib.sh === id: cord-322009-0cwljo0c author: Ma, Ling title: Coinfection of SARS-CoV-2 and Other Respiratory Pathogens date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-322009-0cwljo0c.txt cache: ./cache/cord-322009-0cwljo0c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-322009-0cwljo0c.txt' === file2bib.sh === id: cord-321837-0r86qxz1 author: Zimmerman, Peta-Anne title: A healthy degree of suspicion: A discussion of the implementation of transmission based precautions in the emergency department date: 2016-08-31 pages: extension: .txt txt: ./txt/cord-321837-0r86qxz1.txt cache: ./cache/cord-321837-0r86qxz1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-321837-0r86qxz1.txt' === file2bib.sh === id: cord-322497-hdy3va8e author: LUBANSU, Alphonse title: COVID-19 impact on neurosurgical practice: lockdown attitude and experience of a European academic center. date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-322497-hdy3va8e.txt cache: ./cache/cord-322497-hdy3va8e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-322497-hdy3va8e.txt' === file2bib.sh === id: cord-321552-lsz1onrj author: Membrilla, Javier A. title: Headache as a Cardinal Symptom of Coronavirus Disease 2019: A Cross‐Sectional Study date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-321552-lsz1onrj.txt cache: ./cache/cord-321552-lsz1onrj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321552-lsz1onrj.txt' === file2bib.sh === id: cord-321472-n4nnmlv1 author: Oliveira, E. title: ICU Outcomes and Survival in Patients with Severe COVID-19 in the Largest Health Care System in Central Florida date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-321472-n4nnmlv1.txt cache: ./cache/cord-321472-n4nnmlv1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-321472-n4nnmlv1.txt' === file2bib.sh === id: cord-322552-95bj65qf author: Sang, Charlie Joseph title: ST Elevations in the Era of COVID-19 date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-322552-95bj65qf.txt cache: ./cache/cord-322552-95bj65qf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322552-95bj65qf.txt' === file2bib.sh === id: cord-322322-woz6lwdu author: Marcum, Michelle title: COVID‐19 pandemic and impact on cancer clinical trials: An academic medical center perspective date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-322322-woz6lwdu.txt cache: ./cache/cord-322322-woz6lwdu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-322322-woz6lwdu.txt' === file2bib.sh === id: cord-322990-q07yy5k8 author: Garutti, Mattia title: Seven Shades of Black Thoughts: COVID-19 and Its Psychological Consequences on Cancer Patients date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-322990-q07yy5k8.txt cache: ./cache/cord-322990-q07yy5k8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322990-q07yy5k8.txt' === file2bib.sh === id: cord-322867-1yxxe5d3 author: Hartman, William R title: Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-322867-1yxxe5d3.txt cache: ./cache/cord-322867-1yxxe5d3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322867-1yxxe5d3.txt' === file2bib.sh === id: cord-321784-nubu5fuz author: Salazar, E. title: Treatment of COVID-19 Patients with Convalescent Plasma in Houston, Texas date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-321784-nubu5fuz.txt cache: ./cache/cord-321784-nubu5fuz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321784-nubu5fuz.txt' === file2bib.sh === id: cord-323180-3ih0i81s author: Pardo, Emmanuel title: Nutritional support for critically ill patients with COVID-19: New strategy for a new disease? date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-323180-3ih0i81s.txt cache: ./cache/cord-323180-3ih0i81s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-323180-3ih0i81s.txt' === file2bib.sh === id: cord-322868-o3r0y6bz author: Williams, E. J. title: Routine measurement of serum procalcitonin allows antibiotics to be safely withheld in patients admitted to hospital with SARS-CoV-2 infection. date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-322868-o3r0y6bz.txt cache: ./cache/cord-322868-o3r0y6bz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322868-o3r0y6bz.txt' === file2bib.sh === id: cord-322590-twnlaq24 author: Hoyer, Carolin title: Changes in Demographic and Diagnostic Spectra of Patients with Neurological Symptoms Presenting to an Emergency Department During the COVID-19 Pandemic: A Retrospective Cohort Study date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-322590-twnlaq24.txt cache: ./cache/cord-322590-twnlaq24.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322590-twnlaq24.txt' === file2bib.sh === id: cord-322663-a58e6pp8 author: Giacomelli, Andrea title: 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-322663-a58e6pp8.txt cache: ./cache/cord-322663-a58e6pp8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322663-a58e6pp8.txt' === file2bib.sh === id: cord-322394-b18fv3r3 author: Eichberg, Daniel G title: Telemedicine in Neurosurgery: Lessons Learned from a Systematic Review of the Literature for the COVID-19 Era and Beyond date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-322394-b18fv3r3.txt cache: ./cache/cord-322394-b18fv3r3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-322394-b18fv3r3.txt' === file2bib.sh === id: cord-322102-4fi0y96f author: Zimmermann, Matthias title: Approaches to the management of patients in oral and maxillofacial surgery during COVID-19 pandemic date: 2020-04-04 pages: extension: .txt txt: ./txt/cord-322102-4fi0y96f.txt cache: ./cache/cord-322102-4fi0y96f.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-322102-4fi0y96f.txt' === file2bib.sh === id: cord-322746-28igib4l author: Gosche, John R. title: Acute, subacute, and chronic cervical lymphadenitis in children date: 2007-06-06 pages: extension: .txt txt: ./txt/cord-322746-28igib4l.txt cache: ./cache/cord-322746-28igib4l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322746-28igib4l.txt' === file2bib.sh === id: cord-323225-ou7pppum author: Mondal, R. N. title: Socio-demographic, clinical, hospital admission and oxygen requirement characteristics of COVID-19 patients of Bangladesh date: 2020-08-16 pages: extension: .txt txt: ./txt/cord-323225-ou7pppum.txt cache: ./cache/cord-323225-ou7pppum.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323225-ou7pppum.txt' === file2bib.sh === id: cord-322799-opf1qwgl author: Hiremath, Channabasavaraj Shivalingaiah title: IACTS guidelines: practice of cardiovascular and thoracic surgery in the COVID-19 era date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-322799-opf1qwgl.txt cache: ./cache/cord-322799-opf1qwgl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322799-opf1qwgl.txt' === file2bib.sh === id: cord-322448-s04e6po9 author: Gadsby, Naomi J. title: Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia date: 2016-04-01 pages: extension: .txt txt: ./txt/cord-322448-s04e6po9.txt cache: ./cache/cord-322448-s04e6po9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-322448-s04e6po9.txt' === file2bib.sh === id: cord-322861-q7uk6rdp author: Zanon, Ezio title: How haemophilia A impacts severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) treatment: a case report date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-322861-q7uk6rdp.txt cache: ./cache/cord-322861-q7uk6rdp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322861-q7uk6rdp.txt' === file2bib.sh === id: cord-323133-gdg50omp author: Buzatto, G. P. title: The pathogens profile in children with otitis media with effusion and adenoid hypertrophy date: 2017-02-23 pages: extension: .txt txt: ./txt/cord-323133-gdg50omp.txt cache: ./cache/cord-323133-gdg50omp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323133-gdg50omp.txt' === file2bib.sh === id: cord-323024-blc3mnbj author: Bernard-Valnet, R. title: CSF of SARS-CoV-2 patients with neurological syndromes reveals hints to understand pathophysiology date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-323024-blc3mnbj.txt cache: ./cache/cord-323024-blc3mnbj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323024-blc3mnbj.txt' === file2bib.sh === id: cord-323092-j2u0ny2u author: Crosby, James C. title: COVID‐19: A review of therapeutics under investigation date: 2020-04-19 pages: extension: .txt txt: ./txt/cord-323092-j2u0ny2u.txt cache: ./cache/cord-323092-j2u0ny2u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323092-j2u0ny2u.txt' === file2bib.sh === id: cord-323446-w2ci1bfr author: Pan, Feng title: Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia date: 2020-02-13 pages: extension: .txt txt: ./txt/cord-323446-w2ci1bfr.txt cache: ./cache/cord-323446-w2ci1bfr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323446-w2ci1bfr.txt' === file2bib.sh === id: cord-322957-clf8f90t author: Crespo, Javier title: Resumption of activity in gastroenterology departments. Recommendations by SEPD, AEEH, GETECCU and AEG date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-322957-clf8f90t.txt cache: ./cache/cord-322957-clf8f90t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322957-clf8f90t.txt' === file2bib.sh === id: cord-323538-9dlr6kqh author: Malard, Florent title: COVID-19 outcomes in patients with hematologic disease date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-323538-9dlr6kqh.txt cache: ./cache/cord-323538-9dlr6kqh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323538-9dlr6kqh.txt' === file2bib.sh === id: cord-323255-elwfiima author: Huijskens, E. G. W. title: Evaluation of Patients with Community‐Acquired Pneumonia Caused by Zoonotic Pathogens in an Area with a High Density of Animal Farms date: 2015-07-27 pages: extension: .txt txt: ./txt/cord-323255-elwfiima.txt cache: ./cache/cord-323255-elwfiima.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-323255-elwfiima.txt' === file2bib.sh === id: cord-022633-fr55uod6 author: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 pages: extension: .txt txt: ./txt/cord-022633-fr55uod6.txt cache: ./cache/cord-022633-fr55uod6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-022633-fr55uod6.txt' === file2bib.sh === id: cord-323314-y3k9dntf author: Aggarwal, Sandeep title: Obesity and Metabolic Surgery Society of India (OSSI) Recommendations for Bariatric and Metabolic Surgery Practice During the COVID-19 Pandemic date: 2020-08-22 pages: extension: .txt txt: ./txt/cord-323314-y3k9dntf.txt cache: ./cache/cord-323314-y3k9dntf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323314-y3k9dntf.txt' === file2bib.sh === id: cord-322893-av8hj005 author: MacKoul, Paul title: Laparoscopic-assisted myomectomy with uterine artery occlusion at a freestanding ambulatory surgery center: a case series date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-322893-av8hj005.txt cache: ./cache/cord-322893-av8hj005.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-322893-av8hj005.txt' === file2bib.sh === id: cord-323787-9lq8rkih author: Bösch, Florian title: Attenuated early inflammatory response in solid organ recipients with COVID‐19 date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-323787-9lq8rkih.txt cache: ./cache/cord-323787-9lq8rkih.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323787-9lq8rkih.txt' === file2bib.sh === id: cord-323470-lpeeugdf author: Ates, Omer Faruk title: Thorax magnetic resonance imaging findings in patients with coronavirus disease (COVID-19) date: 2020-08-15 pages: extension: .txt txt: ./txt/cord-323470-lpeeugdf.txt cache: ./cache/cord-323470-lpeeugdf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-323470-lpeeugdf.txt' === file2bib.sh === id: cord-323831-1qadv7r1 author: Coleman, H title: Severe acute respiratory syndrome coronavirus-2 in post-laryngectomy patients: case series of four patients date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-323831-1qadv7r1.txt cache: ./cache/cord-323831-1qadv7r1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-323831-1qadv7r1.txt' === file2bib.sh === id: cord-323809-bocidwg4 author: Patel, Dhwanil title: COVID-19 EXTRAPULMONARY ILLNESS - The Impact of COVID-19 on Nephrology Care date: 2020-07-25 pages: extension: .txt txt: ./txt/cord-323809-bocidwg4.txt cache: ./cache/cord-323809-bocidwg4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323809-bocidwg4.txt' === file2bib.sh === id: cord-323489-ro7kbnu3 author: Arenas, María Dolores title: Protection of nephrology health professionals during the COVID-19 pandemic date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-323489-ro7kbnu3.txt cache: ./cache/cord-323489-ro7kbnu3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-323489-ro7kbnu3.txt' === file2bib.sh === id: cord-323816-3m1iu9j2 author: Singh, Awadhesh Kumar title: Impact of COVID-19 and comorbidities on health and economics: Focus on developing countries and India date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-323816-3m1iu9j2.txt cache: ./cache/cord-323816-3m1iu9j2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323816-3m1iu9j2.txt' === file2bib.sh === id: cord-323965-6mzzibj8 author: Kapoor, Krishan Mohan title: COVID‐19 Pandemic: Consensus Guidelines for Preferred Practices in an Aesthetic Clinic date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-323965-6mzzibj8.txt cache: ./cache/cord-323965-6mzzibj8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323965-6mzzibj8.txt' === file2bib.sh === id: cord-323713-bc00vths author: Volpi, Stefano title: Efficacy and Adverse Events During Janus Kinase Inhibitor Treatment of SAVI Syndrome date: 2019-05-29 pages: extension: .txt txt: ./txt/cord-323713-bc00vths.txt cache: ./cache/cord-323713-bc00vths.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323713-bc00vths.txt' === file2bib.sh === id: cord-323906-ro078y52 author: Sardu, Celestino title: Implications of AB0 blood group in hypertensive patients with covid-19 date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-323906-ro078y52.txt cache: ./cache/cord-323906-ro078y52.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-323906-ro078y52.txt' === file2bib.sh === id: cord-320663-xypg6evo author: Market, Marisa title: Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-320663-xypg6evo.txt cache: ./cache/cord-320663-xypg6evo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-320663-xypg6evo.txt' === file2bib.sh === id: cord-324175-5c4ijkpm author: Kassas, Mohamed El title: COVID-19 in Egypt: Through Crisis to Adaptation; a gastroenterologist’s Perspective date: 2020-07-19 pages: extension: .txt txt: ./txt/cord-324175-5c4ijkpm.txt cache: ./cache/cord-324175-5c4ijkpm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324175-5c4ijkpm.txt' === file2bib.sh === id: cord-324314-os1btxx1 author: Park, Jaehyeon title: Departments of Radiation Oncology Must Prepare for COVID-19 Outbreak date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-324314-os1btxx1.txt cache: ./cache/cord-324314-os1btxx1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-324314-os1btxx1.txt' === file2bib.sh === id: cord-323582-7y8pt72r author: Ahamad, Martuza title: A Machine Learning Model to Identify Early Stage Symptoms of SARS-Cov-2 Infected Patients date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-323582-7y8pt72r.txt cache: ./cache/cord-323582-7y8pt72r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-323582-7y8pt72r.txt' === file2bib.sh === id: cord-324232-nupi7f72 author: Villar, Jesús title: Rationale for Prolonged Corticosteroid Treatment in the Acute Respiratory Distress Syndrome Caused by Coronavirus Disease 2019 date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-324232-nupi7f72.txt cache: ./cache/cord-324232-nupi7f72.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-324232-nupi7f72.txt' === file2bib.sh === id: cord-324007-hapzf0fl author: McGeer, Allison J. title: Diagnostic Testing or Empirical Therapy for Patients Hospitalized with Suspected Influenza: What to Do? date: 2009-01-01 pages: extension: .txt txt: ./txt/cord-324007-hapzf0fl.txt cache: ./cache/cord-324007-hapzf0fl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-324007-hapzf0fl.txt' === file2bib.sh === id: cord-324159-jv3lknl8 author: Ashraf, Muddasir title: Acute Stroke in a Young Patient With Coronavirus Disease 2019 in the Presence of Patent Foramen Ovale date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-324159-jv3lknl8.txt cache: ./cache/cord-324159-jv3lknl8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-324159-jv3lknl8.txt' === file2bib.sh === id: cord-324125-wau2xq0x author: Qiu, Chao title: Epidemiologic report and serologic findings for household contacts of three cases of influenza A (H7N9) virus infection date: 2013-12-16 pages: extension: .txt txt: ./txt/cord-324125-wau2xq0x.txt cache: ./cache/cord-324125-wau2xq0x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324125-wau2xq0x.txt' === file2bib.sh === id: cord-324666-fvk72o0p author: Alharbi, Musa title: Regression of ETV6-NTRK3 Infantile Glioblastoma After First-Line Treatment With Larotrectinib date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-324666-fvk72o0p.txt cache: ./cache/cord-324666-fvk72o0p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324666-fvk72o0p.txt' === file2bib.sh === id: cord-322104-f1dukpso author: Niederman, M.S. title: PNEUMONIA | Community Acquired Pneumonia, Bacterial and Other Common Pathogens date: 2006-05-13 pages: extension: .txt txt: ./txt/cord-322104-f1dukpso.txt cache: ./cache/cord-322104-f1dukpso.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-322104-f1dukpso.txt' === file2bib.sh === id: cord-324148-bllyruh8 author: Loubet, Paul title: Characteristics of human metapneumovirus infection in adults hospitalized for community-acquired influenza-like illness in France, 2012-2018: a retrospective observational study date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-324148-bllyruh8.txt cache: ./cache/cord-324148-bllyruh8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324148-bllyruh8.txt' === file2bib.sh === id: cord-317344-wznzmssz author: Iannitti, T. title: Therapeutical use of probiotic formulations in clinical practice date: 2010-06-23 pages: extension: .txt txt: ./txt/cord-317344-wznzmssz.txt cache: ./cache/cord-317344-wznzmssz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-317344-wznzmssz.txt' === file2bib.sh === id: cord-323910-lms3xw4k author: Putman, Michael title: Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐analysis date: 2020-08-02 pages: extension: .txt txt: ./txt/cord-323910-lms3xw4k.txt cache: ./cache/cord-323910-lms3xw4k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-323910-lms3xw4k.txt' === file2bib.sh === id: cord-323980-rcyjthze author: Willems, Laurent M. title: SARS-CoV-2-related rapid reorganization of an epilepsy outpatient clinic from personal appointments to telemedicine services: A German single-center experience date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-323980-rcyjthze.txt cache: ./cache/cord-323980-rcyjthze.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-323980-rcyjthze.txt' === file2bib.sh === id: cord-324041-lqokztor author: Saussez, Sven title: Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-324041-lqokztor.txt cache: ./cache/cord-324041-lqokztor.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324041-lqokztor.txt' === file2bib.sh === id: cord-324601-s3rgxtg6 author: Mhimbira, F. title: Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study date: 2019-01-31 pages: extension: .txt txt: ./txt/cord-324601-s3rgxtg6.txt cache: ./cache/cord-324601-s3rgxtg6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-324601-s3rgxtg6.txt' === file2bib.sh === id: cord-324060-vvexfg1c author: Bogdanos, Dimitrios P. title: When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients? date: 2020-03-31 pages: extension: .txt txt: ./txt/cord-324060-vvexfg1c.txt cache: ./cache/cord-324060-vvexfg1c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-324060-vvexfg1c.txt' === file2bib.sh === id: cord-324245-cfiekxr4 author: Giorgi-Pierfranceschi, Matteo title: Prevalence of asymptomatic deep vein thrombosis in patients hospitalized with SARS-CoV-2 pneumonia: a cross-sectional study date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-324245-cfiekxr4.txt cache: ./cache/cord-324245-cfiekxr4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324245-cfiekxr4.txt' === file2bib.sh === id: cord-323705-n2rec4i8 author: Varatharaj, Aravinthan title: Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-323705-n2rec4i8.txt cache: ./cache/cord-323705-n2rec4i8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323705-n2rec4i8.txt' === file2bib.sh === id: cord-323647-q67fa0m3 author: Misra, Durga Prasanna title: Benefits and adverse effects of hydroxychloroquine, methotrexate and colchicine: searching for repurposable drug candidates date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-323647-q67fa0m3.txt cache: ./cache/cord-323647-q67fa0m3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-323647-q67fa0m3.txt' === file2bib.sh === id: cord-325619-qmszgw66 author: Ferrari, Andrea title: Children with cancer in the time of COVID‐19: An 8‐week report from the six pediatric onco‐hematology centers in Lombardia, Italy date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-325619-qmszgw66.txt cache: ./cache/cord-325619-qmszgw66.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-325619-qmszgw66.txt' === file2bib.sh === id: cord-325628-pa3dkz2f author: Wang, Jinsong title: Strategy for treating vascular emergencies during the COVID-19 pandemic in China date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-325628-pa3dkz2f.txt cache: ./cache/cord-325628-pa3dkz2f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325628-pa3dkz2f.txt' === file2bib.sh === id: cord-323293-4gmnkg09 author: Sobhani, Navid title: Mutant p53 as an Antigen in Cancer Immunotherapy date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-323293-4gmnkg09.txt cache: ./cache/cord-323293-4gmnkg09.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323293-4gmnkg09.txt' === file2bib.sh === id: cord-321697-yua3apfi author: Crigna, Adriana Torres title: Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope? date: 2020-10-29 pages: extension: .txt txt: ./txt/cord-321697-yua3apfi.txt cache: ./cache/cord-321697-yua3apfi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321697-yua3apfi.txt' === file2bib.sh === id: cord-324880-s1oqkqef author: Xu, Lili title: A fatal case associated with respiratory syncytial virus infection in a young child date: 2018-05-11 pages: extension: .txt txt: ./txt/cord-324880-s1oqkqef.txt cache: ./cache/cord-324880-s1oqkqef.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324880-s1oqkqef.txt' === file2bib.sh === id: cord-324669-qca0uwxo author: Radermecker, Coraline title: Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19 date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-324669-qca0uwxo.txt cache: ./cache/cord-324669-qca0uwxo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324669-qca0uwxo.txt' === file2bib.sh === id: cord-325511-ot66dj3i author: Kim, Philip title: Managing Intrathecal Drug Delivery Devices in a Global Pandemic date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-325511-ot66dj3i.txt cache: ./cache/cord-325511-ot66dj3i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-325511-ot66dj3i.txt' === file2bib.sh === id: cord-325655-1fktmpbj author: Sun, Dan-Qin title: Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-325655-1fktmpbj.txt cache: ./cache/cord-325655-1fktmpbj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-325655-1fktmpbj.txt' === file2bib.sh === id: cord-324843-r43u7sld author: Kockuzu, Esra title: Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey date: 2019-06-17 pages: extension: .txt txt: ./txt/cord-324843-r43u7sld.txt cache: ./cache/cord-324843-r43u7sld.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324843-r43u7sld.txt' === file2bib.sh === id: cord-323761-9m177ozm author: Wang, Huijie title: Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety date: 2020-02-22 pages: extension: .txt txt: ./txt/cord-323761-9m177ozm.txt cache: ./cache/cord-323761-9m177ozm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-323761-9m177ozm.txt' === file2bib.sh === id: cord-324529-xbrdtxnz author: Wang, Ming title: Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China date: 2020-10-07 pages: extension: .txt txt: ./txt/cord-324529-xbrdtxnz.txt cache: ./cache/cord-324529-xbrdtxnz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324529-xbrdtxnz.txt' === file2bib.sh === id: cord-323913-v32c2vda author: Istúriz, Raul E. title: Global Distribution of Infectious Diseases Requiring Intensive Care date: 2006-07-31 pages: extension: .txt txt: ./txt/cord-323913-v32c2vda.txt cache: ./cache/cord-323913-v32c2vda.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323913-v32c2vda.txt' === file2bib.sh === id: cord-325234-skshcrh1 author: Jin, Tingxu title: SARS-CoV-2 presented in the air of an intensive care unit (ICU) date: 2020-08-15 pages: extension: .txt txt: ./txt/cord-325234-skshcrh1.txt cache: ./cache/cord-325234-skshcrh1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-325234-skshcrh1.txt' === file2bib.sh === id: cord-324809-16zvqizl author: Mehta, Neil title: Surveillance and Monitoring of Hepatocellular Carcinoma During the COVID-19 Pandemic date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-324809-16zvqizl.txt cache: ./cache/cord-324809-16zvqizl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-324809-16zvqizl.txt' === file2bib.sh === id: cord-324918-36om8n2d author: Guha, Chandana title: Suspension and resumption of kidney transplant programs during the COVID‐19 pandemic: perspectives from patients, caregivers and potential living donors‐a qualitative study date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-324918-36om8n2d.txt cache: ./cache/cord-324918-36om8n2d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324918-36om8n2d.txt' === file2bib.sh === id: cord-325863-3t73v4ng author: Foss, Francine M. title: Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant patient on Ruxolitinib date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-325863-3t73v4ng.txt cache: ./cache/cord-325863-3t73v4ng.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325863-3t73v4ng.txt' === file2bib.sh === id: cord-324859-0yuhb5dl author: Mulchandani, Rubina title: Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis date: 2020-11-02 pages: extension: .txt txt: ./txt/cord-324859-0yuhb5dl.txt cache: ./cache/cord-324859-0yuhb5dl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-324859-0yuhb5dl.txt' === file2bib.sh === id: cord-325793-5vrr7msw author: Lahiry, Anup K. title: Dermatosurgery Practice and Implications of COVID-19 Pandemic: Recommendations by IADVL SIG Dermatosurgery (IADVL Academy) date: 2020-05-10 pages: extension: .txt txt: ./txt/cord-325793-5vrr7msw.txt cache: ./cache/cord-325793-5vrr7msw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325793-5vrr7msw.txt' === file2bib.sh === id: cord-325316-uffxyas1 author: Gagliano, Annalisa title: COVID-19 Epidemic in the Middle Province of Northern Italy: Impact, Logistics, and Strategy in the First Line Hospital date: 2020-03-24 pages: extension: .txt txt: ./txt/cord-325316-uffxyas1.txt cache: ./cache/cord-325316-uffxyas1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325316-uffxyas1.txt' === file2bib.sh === id: cord-325649-zzhsrytw author: Rispoli, Rossella title: Spine surgery in Italy in the COVID-19 era: Proposal for assessing and responding to the regional state of emergency date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-325649-zzhsrytw.txt cache: ./cache/cord-325649-zzhsrytw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-325649-zzhsrytw.txt' === file2bib.sh === id: cord-325869-3mvjc805 author: Silvestris, Nicola title: A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave? date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-325869-3mvjc805.txt cache: ./cache/cord-325869-3mvjc805.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325869-3mvjc805.txt' === file2bib.sh === id: cord-324619-y7gilopu author: Alam, S.B. title: Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-324619-y7gilopu.txt cache: ./cache/cord-324619-y7gilopu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324619-y7gilopu.txt' === file2bib.sh === id: cord-325766-hbppklm5 author: Brienza, Nicola title: Acute Kidney Injury in Coronavirus Disease 2019 Infected Patients: A Meta-Analytic Study date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-325766-hbppklm5.txt cache: ./cache/cord-325766-hbppklm5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-325766-hbppklm5.txt' === file2bib.sh === id: cord-325970-ivtunxrd author: Yerramilli, Divya title: Palliative Radiotherapy for Oncologic Emergencies in the setting of COVID-19: Approaches to Balancing Risks and Benefits date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-325970-ivtunxrd.txt cache: ./cache/cord-325970-ivtunxrd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325970-ivtunxrd.txt' === file2bib.sh === id: cord-323940-ubazgvov author: Cafiero, Concetta title: Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-323940-ubazgvov.txt cache: ./cache/cord-323940-ubazgvov.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323940-ubazgvov.txt' === file2bib.sh === id: cord-325421-1ysn0kyr author: Christensen, Johanna title: Covid-19 Viremia, Serologies and Clinical Course in a Case Series of Transplant Recipients date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-325421-1ysn0kyr.txt cache: ./cache/cord-325421-1ysn0kyr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325421-1ysn0kyr.txt' === file2bib.sh === id: cord-318803-xpa49sxt author: McFee, Robin B. title: Gulf War Servicemen and Servicewomen: The Long Road Home and the Role of Health Care Professionals to Enhance the Troops' Health and Healing date: 2008-05-31 pages: extension: .txt txt: ./txt/cord-318803-xpa49sxt.txt cache: ./cache/cord-318803-xpa49sxt.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318803-xpa49sxt.txt' === file2bib.sh === id: cord-325307-agaau27o author: Giavedoni, Priscila title: Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-325307-agaau27o.txt cache: ./cache/cord-325307-agaau27o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325307-agaau27o.txt' === file2bib.sh === id: cord-325631-c7jwizpj author: Masetti, Chiara title: High mortality in COVID‐19 patients with mild respiratory disease date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-325631-c7jwizpj.txt cache: ./cache/cord-325631-c7jwizpj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-325631-c7jwizpj.txt' === file2bib.sh === id: cord-326752-45ckkv01 author: Barnett, Brian title: Keeping the wolf at bay: Infection prevention and control measures for inpatient psychiatric facilities in the time of COVID-19 date: 2020-07-12 pages: extension: .txt txt: ./txt/cord-326752-45ckkv01.txt cache: ./cache/cord-326752-45ckkv01.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-326752-45ckkv01.txt' === file2bib.sh === id: cord-326023-vwukiwe4 author: Leung, Char title: Risk factors for predicting mortality in elderly patients with COVID-19: a review of clinical data in China date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-326023-vwukiwe4.txt cache: ./cache/cord-326023-vwukiwe4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-326023-vwukiwe4.txt' === file2bib.sh === id: cord-325783-pqonn0as author: Nicholls, John M title: Lung pathology of fatal severe acute respiratory syndrome date: 2003-05-24 pages: extension: .txt txt: ./txt/cord-325783-pqonn0as.txt cache: ./cache/cord-325783-pqonn0as.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-325783-pqonn0as.txt' === file2bib.sh === id: cord-326703-akn92p1r author: Bartoletti, Michele title: Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-Cov-2 infection: a multicenter cohort study (PREDI-CO study) date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-326703-akn92p1r.txt cache: ./cache/cord-326703-akn92p1r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-326703-akn92p1r.txt' === file2bib.sh === id: cord-326807-dii4u9gj author: Kow, Chia Siang title: Use of low-molecular-weight heparin in COVID-19 patients date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-326807-dii4u9gj.txt cache: ./cache/cord-326807-dii4u9gj.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-326807-dii4u9gj.txt' === file2bib.sh === id: cord-324679-rds8o5z4 author: Grant, Vincent J. title: The Past, Present, and Future of Simulation-based Education for Pediatric Emergency Medicine date: 2016-05-26 pages: extension: .txt txt: ./txt/cord-324679-rds8o5z4.txt cache: ./cache/cord-324679-rds8o5z4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-324679-rds8o5z4.txt' === file2bib.sh === id: cord-325933-1qvpofvp author: Samrah, Shaher M title: Depression and Coping Among COVID-19-Infected Individuals After 10 Days of Mandatory in-Hospital Quarantine, Irbid, Jordan date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-325933-1qvpofvp.txt cache: ./cache/cord-325933-1qvpofvp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-325933-1qvpofvp.txt' === file2bib.sh === id: cord-325971-volbaipv author: Neupane, Karun title: Potential Treatment Options for COVID-19: A Comprehensive Review of Global Pharmacological Development Efforts date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-325971-volbaipv.txt cache: ./cache/cord-325971-volbaipv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325971-volbaipv.txt' === file2bib.sh === id: cord-326994-y8p724s4 author: Mohamad, Osama title: Delaying Dilemmas: Coronavirus Complications Impacting the Management of Prostate Cancer date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-326994-y8p724s4.txt cache: ./cache/cord-326994-y8p724s4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-326994-y8p724s4.txt' === file2bib.sh === id: cord-323273-q53wf6au author: Olivia Li, Ji-Peng title: Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective date: 2020-09-06 pages: extension: .txt txt: ./txt/cord-323273-q53wf6au.txt cache: ./cache/cord-323273-q53wf6au.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-323273-q53wf6au.txt' === file2bib.sh === id: cord-325201-yoy7kdli author: Timsit, Jean-François title: Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics date: 2015-03-26 pages: extension: .txt txt: ./txt/cord-325201-yoy7kdli.txt cache: ./cache/cord-325201-yoy7kdli.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-325201-yoy7kdli.txt' === file2bib.sh === id: cord-326354-fhafg41x author: Pesavento, Raffaele title: The hazard of (sub)therapeutic doses of anticoagulants in non‐critically ill patients with Covid‐19: the Padua province experience date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-326354-fhafg41x.txt cache: ./cache/cord-326354-fhafg41x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326354-fhafg41x.txt' === file2bib.sh === id: cord-326747-zwp13awk author: Sever, Mustafa title: Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients date: 2009-12-28 pages: extension: .txt txt: ./txt/cord-326747-zwp13awk.txt cache: ./cache/cord-326747-zwp13awk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-326747-zwp13awk.txt' === file2bib.sh === id: cord-327017-b2refzfw author: Elbeddini, Ali title: Pharmacist intervention amid the coronavirus disease 2019 (COVID-19) pandemic: from direct patient care to telemedicine date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-327017-b2refzfw.txt cache: ./cache/cord-327017-b2refzfw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327017-b2refzfw.txt' === file2bib.sh === id: cord-327165-vlyfbiem author: Montorfano, Lisandro title: Colorectal surgery obesity-related morbidity during COVID-19 date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-327165-vlyfbiem.txt cache: ./cache/cord-327165-vlyfbiem.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327165-vlyfbiem.txt' === file2bib.sh === id: cord-323463-osf6t7cw author: Cercenado, Emilia title: Update on bacterial pathogens: virulence and resistance date: 2008-04-30 pages: extension: .txt txt: ./txt/cord-323463-osf6t7cw.txt cache: ./cache/cord-323463-osf6t7cw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323463-osf6t7cw.txt' === file2bib.sh === id: cord-327611-g2ssh0fk author: Ishkanian, Amy title: Clinical Conundrum: Dysphagia in a Patient with COVID-19 and Progressive Muscle Weakness date: 2020-10-31 pages: extension: .txt txt: ./txt/cord-327611-g2ssh0fk.txt cache: ./cache/cord-327611-g2ssh0fk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327611-g2ssh0fk.txt' === file2bib.sh === id: cord-326984-o27rp468 author: CHIEN, Jung‐Yien title: Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome date: 2006-10-16 pages: extension: .txt txt: ./txt/cord-326984-o27rp468.txt cache: ./cache/cord-326984-o27rp468.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326984-o27rp468.txt' === file2bib.sh === id: cord-326468-xcy7v1tf author: Mehta, R. M. title: A shorter symptom-onset to remdesivir treatment (SORT) interval is associated with a lower mortality in moderate-to-severe COVID-19: A real-world analysis date: 2020-11-10 pages: extension: .txt txt: ./txt/cord-326468-xcy7v1tf.txt cache: ./cache/cord-326468-xcy7v1tf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326468-xcy7v1tf.txt' === file2bib.sh === id: cord-327125-86ocr70d author: Iehara, Tomoko title: Statement on the prevention and treatment of COVID‐19 in patients with pediatric cancer in Japan date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-327125-86ocr70d.txt cache: ./cache/cord-327125-86ocr70d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327125-86ocr70d.txt' === file2bib.sh === id: cord-326185-gjte739i author: Mukherjee, Pratik title: Adaptability and responsiveness: keys to operational measures in a regional hospital radiology department during the current COVID-19 pandemic date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-326185-gjte739i.txt cache: ./cache/cord-326185-gjte739i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-326185-gjte739i.txt' === file2bib.sh === id: cord-325700-f102uk2m author: Fraser, Douglas D. title: Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-325700-f102uk2m.txt cache: ./cache/cord-325700-f102uk2m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325700-f102uk2m.txt' === file2bib.sh === id: cord-327413-zdbnoy1q author: Bendjelid, Karim title: Hemodynamic monitoring of Covid-19 patients. Classical methods and new paradigms date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-327413-zdbnoy1q.txt cache: ./cache/cord-327413-zdbnoy1q.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327413-zdbnoy1q.txt' === file2bib.sh === id: cord-327148-dzozl70h author: Tahmassebi, Ramon title: Reflections from London’s Level-1 Major Trauma Centres during the COVID crisis date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-327148-dzozl70h.txt cache: ./cache/cord-327148-dzozl70h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327148-dzozl70h.txt' === file2bib.sh === id: cord-326643-obfvi3ms author: Lo Giudice, Roberto title: The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) in Dentistry. Management of Biological Risk in Dental Practice date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-326643-obfvi3ms.txt cache: ./cache/cord-326643-obfvi3ms.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326643-obfvi3ms.txt' === file2bib.sh === id: cord-325963-d0hvukbu author: Faes, Christel title: Time between Symptom Onset, Hospitalisation and Recovery or Death: Statistical Analysis of Belgian COVID-19 Patients date: 2020-10-17 pages: extension: .txt txt: ./txt/cord-325963-d0hvukbu.txt cache: ./cache/cord-325963-d0hvukbu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-325963-d0hvukbu.txt' === file2bib.sh === id: cord-327370-zo0n8wf6 author: Vadukul, Prakash title: Massive pulmonary embolism following recovery from COVID-19 infection: inflammation, thrombosis and the role of extended thromboprophylaxis date: 2020-09-13 pages: extension: .txt txt: ./txt/cord-327370-zo0n8wf6.txt cache: ./cache/cord-327370-zo0n8wf6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-327370-zo0n8wf6.txt' === file2bib.sh === id: cord-327577-c0d09cyk author: Zamora, Alberto title: Heart failure, zip code, and telemetry: a trinomial in need of understanding date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-327577-c0d09cyk.txt cache: ./cache/cord-327577-c0d09cyk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327577-c0d09cyk.txt' === file2bib.sh === id: cord-327214-kcbxyhhh author: Eketunde, Adenike O title: A Review of Postmortem Findings in Patients With COVID-19 date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-327214-kcbxyhhh.txt cache: ./cache/cord-327214-kcbxyhhh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327214-kcbxyhhh.txt' === file2bib.sh === id: cord-326834-eeldyj2u author: Graziani, Desirée title: Characteristics and Prognosis of COVID-19 in Patients with COPD date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-326834-eeldyj2u.txt cache: ./cache/cord-326834-eeldyj2u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-326834-eeldyj2u.txt' === file2bib.sh === id: cord-327432-ogw27tob author: Zhang, Feng-jian title: Expert Consensus on Nurses’ Human Caring for COVID-19 Patients in Different Sites date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-327432-ogw27tob.txt cache: ./cache/cord-327432-ogw27tob.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-327432-ogw27tob.txt' === file2bib.sh === id: cord-326991-m0lfk0a9 author: Nuñez, Jorge H. title: Rethinking Trauma Hospital Services in one of Spain's Largest University Hospitals during the COVID-19 pandemic. How can we organize and help? Our experience. date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-326991-m0lfk0a9.txt cache: ./cache/cord-326991-m0lfk0a9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326991-m0lfk0a9.txt' === file2bib.sh === id: cord-326883-j7pbe50g author: Stöbe, Stephan title: Echocardiographic characteristics of patients with SARS-CoV-2 infection date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-326883-j7pbe50g.txt cache: ./cache/cord-326883-j7pbe50g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-326883-j7pbe50g.txt' === file2bib.sh === id: cord-327397-8rxjju0t author: Zhang, H.-Y. title: A Multicentre Study of 2019 Novel Coronavirus Disease Outcomes of Cancer Patients in Wuhan, China date: 2020-03-26 pages: extension: .txt txt: ./txt/cord-327397-8rxjju0t.txt cache: ./cache/cord-327397-8rxjju0t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327397-8rxjju0t.txt' === file2bib.sh === id: cord-327415-nu1msnui author: Kadiane-Oussou, N’dri Juliette title: COVID-19: comparative clinical features and outcome in 114 patients with or without pneumonia (Nord Franche-Comte Hospital, France) date: 2020-10-10 pages: extension: .txt txt: ./txt/cord-327415-nu1msnui.txt cache: ./cache/cord-327415-nu1msnui.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327415-nu1msnui.txt' === file2bib.sh === id: cord-324810-92fosk3c author: Sharma, Sat title: Role of Antimicrobial Agents in the Management of Exacerbations of COPD date: 2012-08-23 pages: extension: .txt txt: ./txt/cord-324810-92fosk3c.txt cache: ./cache/cord-324810-92fosk3c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-324810-92fosk3c.txt' === file2bib.sh === id: cord-327989-6p39cx2e author: Everaert, Bert title: Emerging cardiological issues during the COVID‐19 pandemic date: 2020-05-16 pages: extension: .txt txt: ./txt/cord-327989-6p39cx2e.txt cache: ./cache/cord-327989-6p39cx2e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327989-6p39cx2e.txt' === file2bib.sh === id: cord-327442-e02y93f6 author: Kastritis, Efstathios title: Systemic autoimmune diseases, anti-rheumatic therapies, COVID-19 infection risk and patient outcomes date: 2020-07-11 pages: extension: .txt txt: ./txt/cord-327442-e02y93f6.txt cache: ./cache/cord-327442-e02y93f6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327442-e02y93f6.txt' === file2bib.sh === id: cord-327349-rxb6zfoc author: Au, Lewis title: Cancer, COVID-19, and antiviral immunity: the CAPTURE study date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-327349-rxb6zfoc.txt cache: ./cache/cord-327349-rxb6zfoc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327349-rxb6zfoc.txt' === file2bib.sh === id: cord-327632-2hz94uuw author: Lv, Na title: Management of oral medicine emergencies during COVID-19: A study to develop practice guidelines date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-327632-2hz94uuw.txt cache: ./cache/cord-327632-2hz94uuw.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327632-2hz94uuw.txt' === file2bib.sh === id: cord-327820-4bm7b934 author: Li, Ning title: Management strategies for the burn ward during COVID-19 pandemic date: 2020-04-02 pages: extension: .txt txt: ./txt/cord-327820-4bm7b934.txt cache: ./cache/cord-327820-4bm7b934.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327820-4bm7b934.txt' === file2bib.sh === id: cord-328068-qoz85x3r author: Alanio, Alexandre title: The presence of Pneumocystis jirovecii in critically ill patients with COVID-19 date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-328068-qoz85x3r.txt cache: ./cache/cord-328068-qoz85x3r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-328068-qoz85x3r.txt' === file2bib.sh === id: cord-327481-m9r0p84v author: Duployez, Nicolas title: Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19 date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-327481-m9r0p84v.txt cache: ./cache/cord-327481-m9r0p84v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-327481-m9r0p84v.txt' === file2bib.sh === id: cord-327720-m6cofbj6 author: Chakrabarti, Amitabha title: Understanding the practice of thoracic surgery during the COVID-19 pandemic date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-327720-m6cofbj6.txt cache: ./cache/cord-327720-m6cofbj6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327720-m6cofbj6.txt' === file2bib.sh === id: cord-326272-ya3r0h1t author: Dobesh, Paul P. title: Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID‐19 date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-326272-ya3r0h1t.txt cache: ./cache/cord-326272-ya3r0h1t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326272-ya3r0h1t.txt' === file2bib.sh === id: cord-324798-qh0cxp10 author: Tanaka, Miho title: Forgoing life-sustaining treatment – a comparative analysis of regulations in Japan, Korea, Taiwan, and England date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-324798-qh0cxp10.txt cache: ./cache/cord-324798-qh0cxp10.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324798-qh0cxp10.txt' === file2bib.sh === id: cord-327545-y3vejwtr author: Shannon, Vickie R. title: Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-327545-y3vejwtr.txt cache: ./cache/cord-327545-y3vejwtr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327545-y3vejwtr.txt' === file2bib.sh === id: cord-326751-fn43p19j author: Herold, Christian J. title: Community-acquired and nosocomial pneumonia date: 2004-01-29 pages: extension: .txt txt: ./txt/cord-326751-fn43p19j.txt cache: ./cache/cord-326751-fn43p19j.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-326751-fn43p19j.txt' === file2bib.sh === id: cord-327836-6o66a4i5 author: Zuily, S title: Thrombose artérielle et veineuse au cours du COVID-19 date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-327836-6o66a4i5.txt cache: ./cache/cord-327836-6o66a4i5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327836-6o66a4i5.txt' === file2bib.sh === id: cord-327827-oliw4ee5 author: Sweid, Ahmad title: Letter: Thrombotic Neurovascular Disease in COVID-19 Patients date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-327827-oliw4ee5.txt cache: ./cache/cord-327827-oliw4ee5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327827-oliw4ee5.txt' === file2bib.sh === id: cord-328040-5qd05e4r author: Zhao, Xin-Ying title: Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-328040-5qd05e4r.txt cache: ./cache/cord-328040-5qd05e4r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328040-5qd05e4r.txt' === file2bib.sh === id: cord-327609-no58ucyq author: Murkey, Jamie A. title: Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing date: 2017-06-13 pages: extension: .txt txt: ./txt/cord-327609-no58ucyq.txt cache: ./cache/cord-327609-no58ucyq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327609-no58ucyq.txt' === file2bib.sh === id: cord-327764-4nlg26p5 author: Sun, Da-wei title: The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: a sentinel? date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-327764-4nlg26p5.txt cache: ./cache/cord-327764-4nlg26p5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-327764-4nlg26p5.txt' === file2bib.sh === id: cord-324635-27q3nxte author: Bouza, Emilio title: The situation of infection in the elderly in Spain: a multidisciplinary opinion document date: 2020-09-08 pages: extension: .txt txt: ./txt/cord-324635-27q3nxte.txt cache: ./cache/cord-324635-27q3nxte.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324635-27q3nxte.txt' === file2bib.sh === id: cord-328786-gkd9xcxa author: Mohammad, Laila Malani title: Necessity of brain imaging in COVID-19 infected patients presenting with acute neurological deficits date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-328786-gkd9xcxa.txt cache: ./cache/cord-328786-gkd9xcxa.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328786-gkd9xcxa.txt' === file2bib.sh === id: cord-326851-0jxdnm1l author: Lee, Sang M. title: Lessons Learned from Battling COVID-19: The Korean Experience date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-326851-0jxdnm1l.txt cache: ./cache/cord-326851-0jxdnm1l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326851-0jxdnm1l.txt' === file2bib.sh === id: cord-327690-di7hfghi author: Yang, Xiaobo title: Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study date: 2020-02-24 pages: extension: .txt txt: ./txt/cord-327690-di7hfghi.txt cache: ./cache/cord-327690-di7hfghi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327690-di7hfghi.txt' === file2bib.sh === id: cord-327961-ysatxwph author: Wang, Le title: Risk factors of 90-day rehospitalization following discharge of pediatric patients hospitalized with mycoplasma Pneumoniae pneumonia date: 2019-11-12 pages: extension: .txt txt: ./txt/cord-327961-ysatxwph.txt cache: ./cache/cord-327961-ysatxwph.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327961-ysatxwph.txt' === file2bib.sh === id: cord-327818-1abweqko author: Kersebaum, Dilara title: The early influence of COVID-19 pandemic-associated restrictions on pain, mood, and everyday life of patients with painful polyneuropathy date: 2020-10-14 pages: extension: .txt txt: ./txt/cord-327818-1abweqko.txt cache: ./cache/cord-327818-1abweqko.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327818-1abweqko.txt' === file2bib.sh === id: cord-327597-fgnrujsf author: Han, Susie A. title: Clinical and Ethical Considerations in Allocation of Ventilators in an Influenza Pandemic or Other Public Health Disaster: A Comparison of the 2007 and 2015 New York State Ventilator Allocation Guidelines date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-327597-fgnrujsf.txt cache: ./cache/cord-327597-fgnrujsf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327597-fgnrujsf.txt' === file2bib.sh === id: cord-328484-4iptwc3n author: Li, Tao title: Clinical Characteristics of 312 Hospitalized Older Patients with COVID-19 in Wuhan, China date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-328484-4iptwc3n.txt cache: ./cache/cord-328484-4iptwc3n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-328484-4iptwc3n.txt' === file2bib.sh === id: cord-328214-2azb8789 author: Piper-Vallillo, Andrew J. title: COVID-19 Infection in a Lung Cancer Patient Population: Incidence, Presentation and Alternative Diagnostic Considerations date: 2020-11-12 pages: extension: .txt txt: ./txt/cord-328214-2azb8789.txt cache: ./cache/cord-328214-2azb8789.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328214-2azb8789.txt' === file2bib.sh === id: cord-328607-lzai90zq author: Augoustides, John G. title: Cardiovascular Consequences and Considerations of Coronavirus Infection – Perspectives for the Cardiothoracic Anesthesiologist and Intensivist During the Coronavirus Crisis date: 2020-04-09 pages: extension: .txt txt: ./txt/cord-328607-lzai90zq.txt cache: ./cache/cord-328607-lzai90zq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328607-lzai90zq.txt' === file2bib.sh === id: cord-329351-g9qlo3xh author: Toraih, Eman A. title: Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID‐19 patients: A meta‐regression and Decision tree analysis date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-329351-g9qlo3xh.txt cache: ./cache/cord-329351-g9qlo3xh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-329351-g9qlo3xh.txt' === file2bib.sh === id: cord-328039-xt17gvcp author: Olson, Michael C. title: RadioGraphics Update: Venous Thrombosis and Hypercoagulability in the Abdomen and Pelvis—Findings in COVID-19 date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-328039-xt17gvcp.txt cache: ./cache/cord-328039-xt17gvcp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328039-xt17gvcp.txt' === file2bib.sh === id: cord-329582-y4gyw8vz author: Tham, Hui-Yu title: Is There Still a Role for Physical Consultation in Colorectal Cancer Surveillance? date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-329582-y4gyw8vz.txt cache: ./cache/cord-329582-y4gyw8vz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-329582-y4gyw8vz.txt' === file2bib.sh === id: cord-328829-yywxmioq author: Boixeda, Ramon title: Microbiological study of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the usefulness of analytical and clinical parameters in its identification (VIRAE study) date: 2012-05-25 pages: extension: .txt txt: ./txt/cord-328829-yywxmioq.txt cache: ./cache/cord-328829-yywxmioq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328829-yywxmioq.txt' === file2bib.sh === id: cord-327622-ezgufe24 author: Kaur, Ramandeep title: Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-327622-ezgufe24.txt cache: ./cache/cord-327622-ezgufe24.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-327622-ezgufe24.txt' === file2bib.sh === id: cord-328147-61gtx2h2 author: Lopez-Mendez, Ivan title: Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19) date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-328147-61gtx2h2.txt cache: ./cache/cord-328147-61gtx2h2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-328147-61gtx2h2.txt' === file2bib.sh === id: cord-328895-p75b7jii author: Kim, Yeon-Yong title: Effects of patients’ motives in choosing a provider on determining the type of medical institution date: 2017-11-22 pages: extension: .txt txt: ./txt/cord-328895-p75b7jii.txt cache: ./cache/cord-328895-p75b7jii.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328895-p75b7jii.txt' === file2bib.sh === id: cord-329564-tmi1u224 author: Arashiro, Takeshi title: COVID-19 in 2 Persons with Mild Upper Respiratory Tract Symptoms on a Cruise Ship, Japan date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-329564-tmi1u224.txt cache: ./cache/cord-329564-tmi1u224.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-329564-tmi1u224.txt' === file2bib.sh === id: cord-328640-4g7revha author: Douedi, Steven title: Novel coronavirus 2019 (COVID-19): A case report and review of treatments date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-328640-4g7revha.txt cache: ./cache/cord-328640-4g7revha.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328640-4g7revha.txt' === file2bib.sh === id: cord-328384-jzfr2t3p author: Mudatsir, Mudatsir title: Predictors of COVID-19 severity: a systematic review and meta-analysis date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-328384-jzfr2t3p.txt cache: ./cache/cord-328384-jzfr2t3p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328384-jzfr2t3p.txt' === file2bib.sh === id: cord-328220-toeq4xq0 author: Smith, Kelly title: Practical Considerations in Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID-19 date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-328220-toeq4xq0.txt cache: ./cache/cord-328220-toeq4xq0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-328220-toeq4xq0.txt' === file2bib.sh === id: cord-329152-1ixylnny author: Gupta, Shaili title: Hospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-329152-1ixylnny.txt cache: ./cache/cord-329152-1ixylnny.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-329152-1ixylnny.txt' === file2bib.sh === id: cord-329863-r2vqsg5r author: Salamanna, Francesca title: Overt and non-overt disseminated intravascular coagulation and the potential role of heparin in the COVID-19 pandemic outbreak date: 2020-10-16 pages: extension: .txt txt: ./txt/cord-329863-r2vqsg5r.txt cache: ./cache/cord-329863-r2vqsg5r.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-329863-r2vqsg5r.txt' === file2bib.sh === id: cord-327641-hqnem2zs author: Ji, Ying-Jie title: Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone date: 2016-11-03 pages: extension: .txt txt: ./txt/cord-327641-hqnem2zs.txt cache: ./cache/cord-327641-hqnem2zs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-327641-hqnem2zs.txt' === file2bib.sh === id: cord-328525-80xk3gln author: Baier, Claas title: Influenza and respiratory syncytial virus screening for the detection of asymptomatically infected patients in hematology and oncology date: 2018-09-24 pages: extension: .txt txt: ./txt/cord-328525-80xk3gln.txt cache: ./cache/cord-328525-80xk3gln.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-328525-80xk3gln.txt' === file2bib.sh === id: cord-330061-q4xi260z author: Ferreira, João Guimarães title: Pneumothorax as a late complication of COVID-19 date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-330061-q4xi260z.txt cache: ./cache/cord-330061-q4xi260z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330061-q4xi260z.txt' === file2bib.sh === id: cord-329453-ry1diso2 author: Hammer, Mark M. title: Radiologist Reporting and Operational Management for Patients with Suspected COVID-19 date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-329453-ry1diso2.txt cache: ./cache/cord-329453-ry1diso2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-329453-ry1diso2.txt' === file2bib.sh === id: cord-328814-s3963anw author: XU, Jing title: Exploration on the feasibility of moxibustion in prevention and treatment of COVID-19 from the perspective of modern medical mechanism date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-328814-s3963anw.txt cache: ./cache/cord-328814-s3963anw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-328814-s3963anw.txt' === file2bib.sh === id: cord-328113-eczjjc2v author: D’Alessandro, Angelo title: Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-328113-eczjjc2v.txt cache: ./cache/cord-328113-eczjjc2v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328113-eczjjc2v.txt' === file2bib.sh === id: cord-330431-9txstz4n author: Nomikos, Iakovos N title: What Else but Covid-19 Pandemic? Lessons Learned date: 2020-07-11 pages: extension: .txt txt: ./txt/cord-330431-9txstz4n.txt cache: ./cache/cord-330431-9txstz4n.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330431-9txstz4n.txt' === file2bib.sh === id: cord-328307-378cfb23 author: Shirazi, Samira title: Sudden cardiac death in COVID-19 patients, a report of three cases date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-328307-378cfb23.txt cache: ./cache/cord-328307-378cfb23.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328307-378cfb23.txt' === file2bib.sh === id: cord-329727-h47q76y8 author: Sisó-Almirall, Antoni title: Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-329727-h47q76y8.txt cache: ./cache/cord-329727-h47q76y8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-329727-h47q76y8.txt' === file2bib.sh === id: cord-330676-urr9oqfc author: Keny, Dr Swapnil title: Emergency and Urgent Orthopaedic Surgeries in non covid patients during the COVID 19 pandemic: Perspective from India date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-330676-urr9oqfc.txt cache: ./cache/cord-330676-urr9oqfc.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330676-urr9oqfc.txt' === file2bib.sh === id: cord-330368-rk31cwl4 author: Bowden, Kasey title: Harnessing the Power of Hospitalists in Operational Disaster Planning: COVID-19 date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-330368-rk31cwl4.txt cache: ./cache/cord-330368-rk31cwl4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330368-rk31cwl4.txt' === file2bib.sh === id: cord-330492-kbob8z48 author: Vervoort, Dominique title: Assessing the Collateral Damage of the Novel Coronavirus: A Call to Action for the Post-COVID-19 Era date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-330492-kbob8z48.txt cache: ./cache/cord-330492-kbob8z48.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330492-kbob8z48.txt' === file2bib.sh === id: cord-329215-awxfetdj author: Carter, Chris title: COVID-19 Disease: invasive ventilation date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-329215-awxfetdj.txt cache: ./cache/cord-329215-awxfetdj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-329215-awxfetdj.txt' === file2bib.sh === id: cord-329877-vish6v8e author: Lapinsky, Stephen E. title: ICU management of severe acute respiratory syndrome date: 2003-05-09 pages: extension: .txt txt: ./txt/cord-329877-vish6v8e.txt cache: ./cache/cord-329877-vish6v8e.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-329877-vish6v8e.txt' === file2bib.sh === id: cord-328487-glwslgjy author: Iannaccone, Sandro title: ROLE OF REHABILITATION DEPARTMENT FOR ADULT COVID-19 PATIENTS: THE EXPERIENCE OF THE SAN RAFFAELE HOSPITAL OF MILAN date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-328487-glwslgjy.txt cache: ./cache/cord-328487-glwslgjy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328487-glwslgjy.txt' === file2bib.sh === id: cord-328289-3h3kmjlz author: Iadecola, Costantino title: Effects of COVID-19 on the nervous system date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-328289-3h3kmjlz.txt cache: ./cache/cord-328289-3h3kmjlz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-328289-3h3kmjlz.txt' === file2bib.sh === id: cord-326017-qw4qynqv author: Laskar, Partha title: “Tomorrow Never Dies”: Recent Advances in Diagnosis, Treatment, and Prevention Modalities against Coronavirus (COVID-19) amid Controversies date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-326017-qw4qynqv.txt cache: ./cache/cord-326017-qw4qynqv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326017-qw4qynqv.txt' === file2bib.sh === id: cord-330655-crfj5adf author: Haider, Asim title: COVID-19 and the Brain: Acute Encephalitis as a Clinical Manifestation date: 2020-10-03 pages: extension: .txt txt: ./txt/cord-330655-crfj5adf.txt cache: ./cache/cord-330655-crfj5adf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330655-crfj5adf.txt' === file2bib.sh === id: cord-329741-604gtqx9 author: Tombetti, Enrico title: Novel Pharmacotherapies for Recurrent Pericarditis: Current Options in 2020 date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-329741-604gtqx9.txt cache: ./cache/cord-329741-604gtqx9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-329741-604gtqx9.txt' === file2bib.sh === id: cord-328569-1lx3fkv3 author: Bagate, François title: Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-328569-1lx3fkv3.txt cache: ./cache/cord-328569-1lx3fkv3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-328569-1lx3fkv3.txt' === file2bib.sh === id: cord-329444-t8ixrdpq author: Persaud., Yudy K. title: Ten Rules for Implementation of a Telemedicine Program to Care for Patients with Asthma date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-329444-t8ixrdpq.txt cache: ./cache/cord-329444-t8ixrdpq.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-329444-t8ixrdpq.txt' === file2bib.sh === id: cord-330666-puhijixa author: Carrico, Ruth M. title: Changing health care worker behavior in relation to respiratory disease transmission with a novel training approach that uses biosimulation date: 2007-02-02 pages: extension: .txt txt: ./txt/cord-330666-puhijixa.txt cache: ./cache/cord-330666-puhijixa.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330666-puhijixa.txt' === file2bib.sh === id: cord-330050-05nnihst author: Li, Yang title: Emergency trauma care during the outbreak of corona virus disease 2019 (COVID-19) in China date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-330050-05nnihst.txt cache: ./cache/cord-330050-05nnihst.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330050-05nnihst.txt' === file2bib.sh === id: cord-330359-c0l5xq5m author: Curran, J title: Reducing potential aerosol generation in flexible nasolaryngoscopy: a novel method date: 2020-07-09 pages: extension: .txt txt: ./txt/cord-330359-c0l5xq5m.txt cache: ./cache/cord-330359-c0l5xq5m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330359-c0l5xq5m.txt' === file2bib.sh === id: cord-324944-ixh3ykrc author: Mitsakakis, Konstantinos title: Diagnostic tools for tackling febrile illness and enhancing patient management date: 2018-12-05 pages: extension: .txt txt: ./txt/cord-324944-ixh3ykrc.txt cache: ./cache/cord-324944-ixh3ykrc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324944-ixh3ykrc.txt' === file2bib.sh === id: cord-330573-rr2r8245 author: Stockmann, Helena title: CytoResc – “CytoSorb” Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-330573-rr2r8245.txt cache: ./cache/cord-330573-rr2r8245.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330573-rr2r8245.txt' === file2bib.sh === id: cord-330136-o8df8szx author: Fan, Hua title: Cardiac injuries in patients with coronavirus disease 2019: Not to be ignored date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-330136-o8df8szx.txt cache: ./cache/cord-330136-o8df8szx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330136-o8df8szx.txt' === file2bib.sh === id: cord-329766-9bwdb6o2 author: Liu, Xiaofan title: Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-329766-9bwdb6o2.txt cache: ./cache/cord-329766-9bwdb6o2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-329766-9bwdb6o2.txt' === file2bib.sh === id: cord-329344-06uk5sjp author: Neumann-Podczaska, Agnieszka title: COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-329344-06uk5sjp.txt cache: ./cache/cord-329344-06uk5sjp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-329344-06uk5sjp.txt' === file2bib.sh === id: cord-329989-176cvimy author: Federico, Antonio title: Scientific publishing in the COVID-19 era: successes and pitfalls date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-329989-176cvimy.txt cache: ./cache/cord-329989-176cvimy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-329989-176cvimy.txt' === file2bib.sh === id: cord-328513-81yvcgul author: Bellastella, Giuseppe title: Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects date: 2016-08-08 pages: extension: .txt txt: ./txt/cord-328513-81yvcgul.txt cache: ./cache/cord-328513-81yvcgul.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-328513-81yvcgul.txt' === file2bib.sh === id: cord-330856-j1wqrc8v author: Matoori, Simon title: Addressing intimate partner violence during the COVID-19 pandemic and beyond: how radiologists can make a difference date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-330856-j1wqrc8v.txt cache: ./cache/cord-330856-j1wqrc8v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330856-j1wqrc8v.txt' === file2bib.sh === id: cord-330963-w24q8sn7 author: Langston, Amelia A. title: Allocating Scarce Healthcare Resources during Pandemics: Making the Case for Patients with Advanced and Metastatic Cancer date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-330963-w24q8sn7.txt cache: ./cache/cord-330963-w24q8sn7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330963-w24q8sn7.txt' === file2bib.sh === id: cord-331109-a8e7r80d author: Ibrahim, Yassmin S. title: Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19 date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-331109-a8e7r80d.txt cache: ./cache/cord-331109-a8e7r80d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331109-a8e7r80d.txt' === file2bib.sh === id: cord-328438-irjo0l4s author: Krittanawong, Chayakrit title: Integration of novel monitoring devices with machine learning technology for scalable cardiovascular management date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-328438-irjo0l4s.txt cache: ./cache/cord-328438-irjo0l4s.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-328438-irjo0l4s.txt' === file2bib.sh === id: cord-329856-0m5mc320 author: Ahmad, Shandar title: Potential of age distribution profiles for the prediction of COVID-19 infection origin in a patient group date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-329856-0m5mc320.txt cache: ./cache/cord-329856-0m5mc320.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-329856-0m5mc320.txt' === file2bib.sh === id: cord-330369-75cotmn2 author: López, Verónica title: Recommendations on management of the SARS-CoV-2 coronavirus pandemic (Covid-19) in kidney transplant patients date: 2020-04-06 pages: extension: .txt txt: ./txt/cord-330369-75cotmn2.txt cache: ./cache/cord-330369-75cotmn2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-330369-75cotmn2.txt' === file2bib.sh === id: cord-329985-5rji08p7 author: Robba, Chiara title: Distinct phenotypes require distinct respiratory management strategies in severe COVID-19 date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-329985-5rji08p7.txt cache: ./cache/cord-329985-5rji08p7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-329985-5rji08p7.txt' === file2bib.sh === id: cord-330597-nftwj0d5 author: Hopfer, Helmut title: Hunting coronavirus by transmission electron microscopy – a guide to SARS‐CoV‐2‐associated ultrastructural pathology in COVID‐19 tissues date: 2020-09-27 pages: extension: .txt txt: ./txt/cord-330597-nftwj0d5.txt cache: ./cache/cord-330597-nftwj0d5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330597-nftwj0d5.txt' === file2bib.sh === id: cord-331449-0sow1im8 author: Saha, Shivangi title: Managing Burns During COVID-19 Outbreak date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-331449-0sow1im8.txt cache: ./cache/cord-331449-0sow1im8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-331449-0sow1im8.txt' === file2bib.sh === id: cord-330701-k68b0wqe author: Gerc, Vjekoslav title: Cardiovascular Diseases (CVDs) in COVID-19 Pandemic Era date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-330701-k68b0wqe.txt cache: ./cache/cord-330701-k68b0wqe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330701-k68b0wqe.txt' === file2bib.sh === id: cord-331317-q01uos7a author: Suh, Gee Young title: Early Intervention Can Improve Clinical Outcome of Acute Interstitial Pneumonia date: 2015-12-30 pages: extension: .txt txt: ./txt/cord-331317-q01uos7a.txt cache: ./cache/cord-331317-q01uos7a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-331317-q01uos7a.txt' === file2bib.sh === id: cord-313474-1gux1gsi author: nan title: Physicians Abstracts date: 2015-03-20 pages: extension: .txt txt: ./txt/cord-313474-1gux1gsi.txt cache: ./cache/cord-313474-1gux1gsi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-313474-1gux1gsi.txt' === file2bib.sh === id: cord-330877-nsx4b4rm author: Elcioglu, Omer Celal title: COVİD-19 infection in a membranous nephropathy patient treated with rituximab date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-330877-nsx4b4rm.txt cache: ./cache/cord-330877-nsx4b4rm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330877-nsx4b4rm.txt' === file2bib.sh === id: cord-330870-l0ryikhv author: Eubanks, Allison title: Obstetric Simulation for a Pandemic date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-330870-l0ryikhv.txt cache: ./cache/cord-330870-l0ryikhv.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330870-l0ryikhv.txt' === file2bib.sh === id: cord-331434-2x9m37cw author: Kumar Jain, Vijay title: Fracture management during COVID-19 pandemic: A systematic review and meta-analysis date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-331434-2x9m37cw.txt cache: ./cache/cord-331434-2x9m37cw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331434-2x9m37cw.txt' === file2bib.sh === id: cord-330918-hsy8h1vb author: Song, Jia title: A Comparison of Clinical Characteristics and Outcomes in Elderly and Younger Patients with COVID-19 date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-330918-hsy8h1vb.txt cache: ./cache/cord-330918-hsy8h1vb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330918-hsy8h1vb.txt' === file2bib.sh === id: cord-330869-k5ro0edf author: Kumar Singh, Awadhesh title: Assessment of risk, severity, mortality, glycemic control and antidiabetic agents in patients with diabetes and COVID-19: A Narrative Review date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-330869-k5ro0edf.txt cache: ./cache/cord-330869-k5ro0edf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330869-k5ro0edf.txt' === file2bib.sh === id: cord-331452-y5lhawqo author: Lentz, Skyler title: High-Risk Airway Management in the Emergency Department: Diseases and Approaches Part I date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-331452-y5lhawqo.txt cache: ./cache/cord-331452-y5lhawqo.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331452-y5lhawqo.txt' === file2bib.sh === id: cord-331827-amg309uz author: Keske, Şiran title: Human metapneumovirus infection: Diagnostic impact of radiologic imaging date: 2019-02-01 pages: extension: .txt txt: ./txt/cord-331827-amg309uz.txt cache: ./cache/cord-331827-amg309uz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331827-amg309uz.txt' === file2bib.sh === id: cord-023049-fio7cjj5 author: nan title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date: 2017-06-22 pages: extension: .txt txt: ./txt/cord-023049-fio7cjj5.txt cache: ./cache/cord-023049-fio7cjj5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 15 resourceName b'cord-023049-fio7cjj5.txt' === file2bib.sh === id: cord-331604-jf6ybip5 author: Moratto, Daniele title: Flow Cytometry Identifies Risk Factors and Dynamic Changes in Patients with COVID-19 date: 2020-06-27 pages: extension: .txt txt: ./txt/cord-331604-jf6ybip5.txt cache: ./cache/cord-331604-jf6ybip5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-331604-jf6ybip5.txt' === file2bib.sh === id: cord-331273-1fixwxuo author: Abejón González, David title: How to restart the interventional activity in the COVID‐19 era. The experience of a private Pain Unit in Spain date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-331273-1fixwxuo.txt cache: ./cache/cord-331273-1fixwxuo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331273-1fixwxuo.txt' === file2bib.sh === id: cord-332036-op6s8tr4 author: Feldman, Candace H. title: Widening Disparities Among Patients with Rheumatic Diseases in the COVID‐19 Era: An Urgent Call to Action date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-332036-op6s8tr4.txt cache: ./cache/cord-332036-op6s8tr4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332036-op6s8tr4.txt' === file2bib.sh === id: cord-333451-p2plpeew author: Raab, Anja M. title: Significant demands on healthcare resources during the COVID crisis date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-333451-p2plpeew.txt cache: ./cache/cord-333451-p2plpeew.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-333451-p2plpeew.txt' === file2bib.sh === id: cord-332709-0plblo4k author: Zodda, David title: Optimizing Non-invasive Oxygenation for COVID-19 Patients Presenting to the Emergency Department with Acute Respiratory Distress: A Case Report date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-332709-0plblo4k.txt cache: ./cache/cord-332709-0plblo4k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332709-0plblo4k.txt' === file2bib.sh === id: cord-332087-xwturwju author: McGlynn, Fergal title: Argatroban for therapeutic anticoagulation for heparin resistance associated with Covid-19 infection date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-332087-xwturwju.txt cache: ./cache/cord-332087-xwturwju.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332087-xwturwju.txt' === file2bib.sh === id: cord-330831-3b7vfv9b author: Hao, Fengyi title: A quantitative and qualitative study on the neuropsychiatric sequelae of acutely ill COVID-19 inpatients in isolation facilities date: 2020-10-19 pages: extension: .txt txt: ./txt/cord-330831-3b7vfv9b.txt cache: ./cache/cord-330831-3b7vfv9b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-330831-3b7vfv9b.txt' === file2bib.sh === id: cord-331114-lumfg138 author: Berkman, Samuel A title: Methodological Issues and Controversies in COVID-19 Coagulopathy: A Tale of Two Storms date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-331114-lumfg138.txt cache: ./cache/cord-331114-lumfg138.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331114-lumfg138.txt' === file2bib.sh === id: cord-328294-gii1b7s7 author: Doty, Richard L. title: Olfaction and Its Alteration by Nasal Obstruction, Rhinitis, and Rhinosinusitis date: 2009-01-02 pages: extension: .txt txt: ./txt/cord-328294-gii1b7s7.txt cache: ./cache/cord-328294-gii1b7s7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-328294-gii1b7s7.txt' === file2bib.sh === id: cord-331547-uqmjhhna author: Bonalumi, Giorgia title: A call to action becomes practice: cardiac and vascular surgery during the COVID-19 pandemic based on the Lombardy emergency guidelines date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-331547-uqmjhhna.txt cache: ./cache/cord-331547-uqmjhhna.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-331547-uqmjhhna.txt' === file2bib.sh === id: cord-331762-b0yufidn author: Rudski, Lawrence title: Multimodality Imaging in Evaluation of Cardiovascular complications in Patients with COVID-19 date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-331762-b0yufidn.txt cache: ./cache/cord-331762-b0yufidn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331762-b0yufidn.txt' === file2bib.sh === id: cord-333588-3krh1xzx author: Sharma, Amita title: Pediatric Dentistry during Coronavirus Disease-2019 Pandemic: A Paradigm Shift in Treatment Options date: 2020 pages: extension: .txt txt: ./txt/cord-333588-3krh1xzx.txt cache: ./cache/cord-333588-3krh1xzx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333588-3krh1xzx.txt' === file2bib.sh === id: cord-331270-12zx0o2p author: Rico, Timóteo Matthies title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-331270-12zx0o2p.txt cache: ./cache/cord-331270-12zx0o2p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-331270-12zx0o2p.txt' === file2bib.sh === id: cord-331481-zeaqi1uc author: Al-Ani, Fatimah title: Thrombosis risk associated with COVID-19 infection. A scoping review date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-331481-zeaqi1uc.txt cache: ./cache/cord-331481-zeaqi1uc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331481-zeaqi1uc.txt' === file2bib.sh === id: cord-332145-rw16o02g author: Chen, Patrick M. title: Evolving Healthcare Delivery in Neurology During the Coronavirus Disease 2019 (COVID-19) Pandemic date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-332145-rw16o02g.txt cache: ./cache/cord-332145-rw16o02g.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-332145-rw16o02g.txt' === file2bib.sh === id: cord-332861-7b5pzmk6 author: Zhang, Zhan title: Clinical Features and Treatment of 2019-nCov Pneumonia Patients in Wuhan: Report of A Couple Cases date: 2020-02-07 pages: extension: .txt txt: ./txt/cord-332861-7b5pzmk6.txt cache: ./cache/cord-332861-7b5pzmk6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-332861-7b5pzmk6.txt' === file2bib.sh === id: cord-334524-8uqnlpvc author: Johannson, Kerri A. title: Remote Monitoring in Idiopathic Pulmonary Fibrosis: Home Is Where the Bluetooth-enabled Spirometer Is date: 2020-08-01 pages: extension: .txt txt: ./txt/cord-334524-8uqnlpvc.txt cache: ./cache/cord-334524-8uqnlpvc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334524-8uqnlpvc.txt' === file2bib.sh === id: cord-331915-7idktu7c author: Cieslak, Theodore J title: A Brief History of Biocontainment date: 2016-10-20 pages: extension: .txt txt: ./txt/cord-331915-7idktu7c.txt cache: ./cache/cord-331915-7idktu7c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-331915-7idktu7c.txt' === file2bib.sh === id: cord-331519-ye4dtna5 author: Garibaldi, B. T. title: Patient trajectories and risk factors for severe outcomes among persons hospitalized for COVID-19 in the Maryland/DC region date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-331519-ye4dtna5.txt cache: ./cache/cord-331519-ye4dtna5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-331519-ye4dtna5.txt' === file2bib.sh === id: cord-332013-bl5d4xkc author: Sánchez-Álvarez, J. Emilio title: Status of SARS-CoV-2 infection in patients on renal replacement therapy Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN) date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-332013-bl5d4xkc.txt cache: ./cache/cord-332013-bl5d4xkc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-332013-bl5d4xkc.txt' === file2bib.sh === id: cord-331487-jh34klbg author: Sivapalan, Pradeesh title: Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-331487-jh34klbg.txt cache: ./cache/cord-331487-jh34klbg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331487-jh34klbg.txt' === file2bib.sh === id: cord-332150-j76726no author: De Stefano, Ludovico title: A “Window of Therapeutic Opportunity” for Anti-Cytokine Therapy in Patients With Coronavirus Disease 2019 date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-332150-j76726no.txt cache: ./cache/cord-332150-j76726no.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332150-j76726no.txt' === file2bib.sh === id: cord-332278-2p64ab2z author: Vivas, David title: Recomendaciones sobre el tratamiento antitrombótico durante la pandemia COVID-19. Posicionamiento del Grupo de Trabajo de Trombosis Cardiovascular de la Sociedad Española de Cardiología date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-332278-2p64ab2z.txt cache: ./cache/cord-332278-2p64ab2z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332278-2p64ab2z.txt' === file2bib.sh === id: cord-326785-le2t1l8g author: nan title: Pathological Society of Great Britain and Ireland. 163rd meeting, 3–5 July 1991 date: 2005-06-15 pages: extension: .txt txt: ./txt/cord-326785-le2t1l8g.txt cache: ./cache/cord-326785-le2t1l8g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326785-le2t1l8g.txt' === file2bib.sh === id: cord-333816-cznwzcn9 author: Chung, Michael title: CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) date: 2020-02-04 pages: extension: .txt txt: ./txt/cord-333816-cznwzcn9.txt cache: ./cache/cord-333816-cznwzcn9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333816-cznwzcn9.txt' === file2bib.sh === id: cord-331165-2yn1n3eq author: Tauben, David J. title: Optimizing telehealth pain care after COVID-19 date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-331165-2yn1n3eq.txt cache: ./cache/cord-331165-2yn1n3eq.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-331165-2yn1n3eq.txt' === file2bib.sh === id: cord-333470-0a0i6vjn author: Lombe, Dorothy C title: Zambia’s National Cancer Centre response to the COVID-19 pandemic—an opportunity for improved care date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-333470-0a0i6vjn.txt cache: ./cache/cord-333470-0a0i6vjn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-333470-0a0i6vjn.txt' === file2bib.sh === id: cord-334715-902pfxyz author: Sirico, Domenico title: Cardiac imaging in congenital heart disease during the coronavirus disease-2019 pandemic: recommendations from the Working Group on Congenital Heart Disease of the Italian Society of Cardiology date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-334715-902pfxyz.txt cache: ./cache/cord-334715-902pfxyz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-334715-902pfxyz.txt' === file2bib.sh === id: cord-332153-fczf3lzc author: Azkur, Ahmet Kursat title: Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19 date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-332153-fczf3lzc.txt cache: ./cache/cord-332153-fczf3lzc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332153-fczf3lzc.txt' === file2bib.sh === id: cord-333684-j1sg46w9 author: Filippi, Federica title: COVID‐19 era: A chance to learn something new about monitoring psoriatic patients in biological therapy date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-333684-j1sg46w9.txt cache: ./cache/cord-333684-j1sg46w9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-333684-j1sg46w9.txt' === file2bib.sh === id: cord-334324-remrcm2q author: Kunal, Shekhar title: Cardiovascular complications and its impact on outcomes in COVID-19 date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-334324-remrcm2q.txt cache: ./cache/cord-334324-remrcm2q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-334324-remrcm2q.txt' === file2bib.sh === id: cord-333453-v3gap8kj author: Dima, Mirabela title: First neonates with severe acute respiratory syndrome coronavirus 2 infection in Romania: Three case reports date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-333453-v3gap8kj.txt cache: ./cache/cord-333453-v3gap8kj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333453-v3gap8kj.txt' === file2bib.sh === id: cord-334790-lav794w0 author: Jin, Huijuan title: Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists date: 2020-04-01 pages: extension: .txt txt: ./txt/cord-334790-lav794w0.txt cache: ./cache/cord-334790-lav794w0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-334790-lav794w0.txt' === file2bib.sh === id: cord-334075-ruqd2c1j author: Der Sarkissian, Samuel title: Response of a tertiary dermatology department to COVID‐19 date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-334075-ruqd2c1j.txt cache: ./cache/cord-334075-ruqd2c1j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-334075-ruqd2c1j.txt' === file2bib.sh === id: cord-332055-lrpfzsog author: DeVos, Elizabeth title: Approach to Adult Patients with Acute Dyspnea date: 2015-11-27 pages: extension: .txt txt: ./txt/cord-332055-lrpfzsog.txt cache: ./cache/cord-332055-lrpfzsog.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-332055-lrpfzsog.txt' === file2bib.sh === id: cord-333183-xyuj1j57 author: Lee, Lennard Y W title: COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-333183-xyuj1j57.txt cache: ./cache/cord-333183-xyuj1j57.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-333183-xyuj1j57.txt' === file2bib.sh === id: cord-332788-8lq9qygn author: Manda, Sudhir title: Feasibility of Long-Term Proteasome Inhibition in Multiple Myeloma by In-Class Transition from Bortezomib to Ixazomib date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-332788-8lq9qygn.txt cache: ./cache/cord-332788-8lq9qygn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-332788-8lq9qygn.txt' === file2bib.sh === id: cord-334367-w96iqo6q author: Devlin, John W. title: Strategies to Optimize ICU Liberation (A to F) Bundle Performance in Critically Ill Adults With Coronavirus Disease 2019 date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-334367-w96iqo6q.txt cache: ./cache/cord-334367-w96iqo6q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-334367-w96iqo6q.txt' === file2bib.sh === id: cord-333429-bq7kfpby author: Shi, Ding title: Clinical characteristics and factors associated with long-term viral excretion in patients with SARS-CoV-2 infection: a single center 28-day study date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-333429-bq7kfpby.txt cache: ./cache/cord-333429-bq7kfpby.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333429-bq7kfpby.txt' === file2bib.sh === id: cord-333375-d7cgvjsm author: Phoon, Laiyee title: Recommendations on diagnosis and treatment in hepatobiliary surgery under 2019-nCoV epidemic date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-333375-d7cgvjsm.txt cache: ./cache/cord-333375-d7cgvjsm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-333375-d7cgvjsm.txt' === file2bib.sh === id: cord-332180-dw4h69tp author: Cheng, Fu-Yuan title: Using Machine Learning to Predict ICU Transfer in Hospitalized COVID-19 Patients date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-332180-dw4h69tp.txt cache: ./cache/cord-332180-dw4h69tp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332180-dw4h69tp.txt' === file2bib.sh === id: cord-334408-w0yxz7zb author: Rosca, Paola title: Isolating the isolated: Implications of COVID-19 quarantine measures on in-patient detoxification treatment for substance use disorders date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-334408-w0yxz7zb.txt cache: ./cache/cord-334408-w0yxz7zb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334408-w0yxz7zb.txt' === file2bib.sh === id: cord-333113-0k6xlmem author: Tran, V.-T. title: Association between corticosteroids and intubation or death among patients with COVID-19 pneumonia in non-ICU settings: an observational study using of real-world data from 51 hospitals in France and Luxembourg date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-333113-0k6xlmem.txt cache: ./cache/cord-333113-0k6xlmem.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333113-0k6xlmem.txt' === file2bib.sh === id: cord-333696-3ci9re9a author: Alomari, Safwan O. title: COVID-19 and the Central Nervous System date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-333696-3ci9re9a.txt cache: ./cache/cord-333696-3ci9re9a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333696-3ci9re9a.txt' === file2bib.sh === id: cord-333340-ekok0mp5 author: Graf, Erin H. title: Appropriate Use and Future Directions of Molecular Diagnostic Testing date: 2020-02-06 pages: extension: .txt txt: ./txt/cord-333340-ekok0mp5.txt cache: ./cache/cord-333340-ekok0mp5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333340-ekok0mp5.txt' === file2bib.sh === id: cord-332774-t5untewz author: Vaccaro, Alexander R. title: Practice Management During the COVID-19 Pandemic date: 2020-04-13 pages: extension: .txt txt: ./txt/cord-332774-t5untewz.txt cache: ./cache/cord-332774-t5untewz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332774-t5untewz.txt' === file2bib.sh === id: cord-331500-l3hkn2li author: Luyt, Charles-Edouard title: Pulmonary infections complicating ARDS date: 2020-11-11 pages: extension: .txt txt: ./txt/cord-331500-l3hkn2li.txt cache: ./cache/cord-331500-l3hkn2li.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331500-l3hkn2li.txt' === file2bib.sh === id: cord-334212-3gqzeakb author: Chun, Tristen T. title: Phlegmasia Cerulea Dolens Associated with Acute COVID-19 Pneumonia Despite Supratherapeutic Warfarin Anticoagulation date: 2020-10-19 pages: extension: .txt txt: ./txt/cord-334212-3gqzeakb.txt cache: ./cache/cord-334212-3gqzeakb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334212-3gqzeakb.txt' === file2bib.sh === id: cord-333698-e73d9lbu author: Lechien, Jerome R. title: Features of Mild-to-Moderate COVID-19 Patients with Dysphonia. date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-333698-e73d9lbu.txt cache: ./cache/cord-333698-e73d9lbu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333698-e73d9lbu.txt' === file2bib.sh === id: cord-333175-klnxnxwm author: Hussein, Mohammad H. title: Asthma in COVID-19 patients: An extra chain fitting around the neck? date: 2020-11-11 pages: extension: .txt txt: ./txt/cord-333175-klnxnxwm.txt cache: ./cache/cord-333175-klnxnxwm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-333175-klnxnxwm.txt' === file2bib.sh === id: cord-333688-bykbyojs author: Wang, Junxue title: Persistent SARS-COV-2 RNA positivity in a patient for 92 days after disease onset: A case report date: 2020-08-21 pages: extension: .txt txt: ./txt/cord-333688-bykbyojs.txt cache: ./cache/cord-333688-bykbyojs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333688-bykbyojs.txt' === file2bib.sh === id: cord-333528-9mczqtje author: Mattogno, P. P. title: Transnasal endoscopic skull base surgery during COVID-19 pandemic: algorithm of management in an Italian reference COVID center date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-333528-9mczqtje.txt cache: ./cache/cord-333528-9mczqtje.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333528-9mczqtje.txt' === file2bib.sh === id: cord-334235-ymsiihwd author: Gray, Belinda title: Patients with Genetic Heart Disease and COVID-19: A Cardiac Society of Australia and New Zealand (CSANZ) Consensus Statement date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-334235-ymsiihwd.txt cache: ./cache/cord-334235-ymsiihwd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-334235-ymsiihwd.txt' === file2bib.sh === id: cord-335078-z7k59k8o author: Burton-Papp, Helmi C. title: Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-335078-z7k59k8o.txt cache: ./cache/cord-335078-z7k59k8o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335078-z7k59k8o.txt' === file2bib.sh === id: cord-335168-3ofarutr author: Bhat, Yasmeen Jabeen title: Impact of COVID-19 Pandemic on Dermatologists and Dermatology Practice date: 2020-05-10 pages: extension: .txt txt: ./txt/cord-335168-3ofarutr.txt cache: ./cache/cord-335168-3ofarutr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335168-3ofarutr.txt' === file2bib.sh === id: cord-334092-50r3h7jv author: Loungani, Rahul S. title: A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response date: 2020-05-03 pages: extension: .txt txt: ./txt/cord-334092-50r3h7jv.txt cache: ./cache/cord-334092-50r3h7jv.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334092-50r3h7jv.txt' === file2bib.sh === id: cord-335033-cwhm7v0s author: Vergano, Marco title: Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic date: 2020-04-22 pages: extension: .txt txt: ./txt/cord-335033-cwhm7v0s.txt cache: ./cache/cord-335033-cwhm7v0s.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-335033-cwhm7v0s.txt' === file2bib.sh === id: cord-331268-kzy33hdb author: Lynch, Sharon G. title: Multiple sclerosis date: 1996-01-31 pages: extension: .txt txt: ./txt/cord-331268-kzy33hdb.txt cache: ./cache/cord-331268-kzy33hdb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331268-kzy33hdb.txt' === file2bib.sh === id: cord-333808-deifddar author: McGregor, Bradley A title: Remote Oncology Care: Review of Current Technology and Future Directions date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-333808-deifddar.txt cache: ./cache/cord-333808-deifddar.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-333808-deifddar.txt' === file2bib.sh === id: cord-333024-1yrmun3z author: von Lilienfeld-Toal, Marie title: Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology date: 2016-09-25 pages: extension: .txt txt: ./txt/cord-333024-1yrmun3z.txt cache: ./cache/cord-333024-1yrmun3z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-333024-1yrmun3z.txt' === file2bib.sh === id: cord-332480-3uodkrkp author: Bonam, Srinivasa Reddy title: Adjunct immunotherapies for the management of severely ill COVID-19 patients date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-332480-3uodkrkp.txt cache: ./cache/cord-332480-3uodkrkp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-332480-3uodkrkp.txt' === file2bib.sh === id: cord-331533-0toegbv8 author: Leiker, Brenna title: COVID – 19 CASE STUDY IN EMERGENCY MEDICINE PREPAREDNESS AND RESPONSE; FROM PERSONAL PROTECTIVE EQUIPMENT TO DELIVERGY OF CARE date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-331533-0toegbv8.txt cache: ./cache/cord-331533-0toegbv8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-331533-0toegbv8.txt' === file2bib.sh === id: cord-334002-irbpehts author: Silva, Michelle A title: Telehealth treatment engagement with Latinx populations during the COVID-19 pandemic date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-334002-irbpehts.txt cache: ./cache/cord-334002-irbpehts.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334002-irbpehts.txt' === file2bib.sh === id: cord-334881-x9nxxled author: Di Lorenzo, Giuseppe title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-334881-x9nxxled.txt cache: ./cache/cord-334881-x9nxxled.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-334881-x9nxxled.txt' === file2bib.sh === id: cord-334188-bggt1i2e author: Solari, Domenico title: The nose lid for the endoscopic endonasal procedures during COVID-19 era: technical note date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-334188-bggt1i2e.txt cache: ./cache/cord-334188-bggt1i2e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334188-bggt1i2e.txt' === file2bib.sh === id: cord-333876-fhxkpbq7 author: Rucker, Janet C. title: Cerebellum—Editorial Regarding Consensus Paper Consensus on Virtual Management of Vestibular Disorders: Urgent Versus Expedited Care. Shaikh et al., doi.org/10.1007/s12311-020—01178-8: The Return of the House Call: Evaluating Acutely Ill Patients with Vertigo in the Era of Virtual Health Care date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-333876-fhxkpbq7.txt cache: ./cache/cord-333876-fhxkpbq7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-333876-fhxkpbq7.txt' === file2bib.sh === id: cord-335312-yp73z008 author: Bergsland, Emily K. title: North American Neuroendocrine Tumor Society Guide for Neuroendocrine Tumor Patient Health Care Providers During COVID-19 date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-335312-yp73z008.txt cache: ./cache/cord-335312-yp73z008.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-335312-yp73z008.txt' === file2bib.sh === id: cord-335351-8hdok02n author: Hashmi, Muhammad Daniyal title: Assessing the need for transfer to the intensive care unit for Coronavirus-19 disease: Epidemiology and risk factors date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-335351-8hdok02n.txt cache: ./cache/cord-335351-8hdok02n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335351-8hdok02n.txt' === file2bib.sh === id: cord-332233-01rdlf8l author: Tully, Thomas N. title: CHAPTER 12 MICE AND RATS date: 2009-12-31 pages: extension: .txt txt: ./txt/cord-332233-01rdlf8l.txt cache: ./cache/cord-332233-01rdlf8l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332233-01rdlf8l.txt' === file2bib.sh === id: cord-332778-rf47ptj6 author: Vivarelli, Silvia title: Cancer Management during COVID-19 Pandemic: Is Immune Checkpoint Inhibitors-Based Immunotherapy Harmful or Beneficial? date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-332778-rf47ptj6.txt cache: ./cache/cord-332778-rf47ptj6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-332778-rf47ptj6.txt' === file2bib.sh === id: cord-335719-tnimrff9 author: Wang, Chia-shi title: eHealth in kidney care date: 2020-04-01 pages: extension: .txt txt: ./txt/cord-335719-tnimrff9.txt cache: ./cache/cord-335719-tnimrff9.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-335719-tnimrff9.txt' === file2bib.sh === id: cord-335759-io18c6z0 author: Sprik, Petra title: Feasibility and acceptability of a telephone-based chaplaincy intervention in a large, outpatient oncology center date: 2020-07-04 pages: extension: .txt txt: ./txt/cord-335759-io18c6z0.txt cache: ./cache/cord-335759-io18c6z0.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335759-io18c6z0.txt' === file2bib.sh === id: cord-335198-qp964238 author: Kotsimbos, T. title: Pandemic Treatments on Trial: The bigger picture date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-335198-qp964238.txt cache: ./cache/cord-335198-qp964238.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-335198-qp964238.txt' === file2bib.sh === id: cord-332650-05oz5zwz author: Fiorelli, Silvia title: Perspectives in surgical and anaesthetic management of lung cancer in the era of coronavirus disease 2019 (COVID-19) date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-332650-05oz5zwz.txt cache: ./cache/cord-332650-05oz5zwz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-332650-05oz5zwz.txt' === file2bib.sh === id: cord-335576-b34nc3ay author: Tsai, Andrew title: Impact of tocilizumab administration on mortality in severe COVID-19 date: 2020-11-05 pages: extension: .txt txt: ./txt/cord-335576-b34nc3ay.txt cache: ./cache/cord-335576-b34nc3ay.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335576-b34nc3ay.txt' === file2bib.sh === id: cord-333654-8rg99di5 author: Pillai, Presaad title: COVID-19 AND MAJOR ORGAN THROMBOEMBOLISM: MANIFESTATIONS IN NEUROVASCULAR AND CARDIOVASCULAR SYSTEMS. date: 2020-10-24 pages: extension: .txt txt: ./txt/cord-333654-8rg99di5.txt cache: ./cache/cord-333654-8rg99di5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-333654-8rg99di5.txt' === file2bib.sh === id: cord-336194-5v395xae author: Darafsheh, Arash title: Mitigating disruptions, and scalability of radiation oncology physics work during the COVID‐19 pandemic date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-336194-5v395xae.txt cache: ./cache/cord-336194-5v395xae.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336194-5v395xae.txt' === file2bib.sh === id: cord-336252-e92omqyr author: Chen, Tracy Yixin title: COVID‐19 pneumonia in kidney transplant recipients: Focus on immunosuppression management date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-336252-e92omqyr.txt cache: ./cache/cord-336252-e92omqyr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336252-e92omqyr.txt' === file2bib.sh === id: cord-333142-ek7hct52 author: Patel, Shivani A. title: The Integrated Tracking, Referral, and Electronic Decision Support, and Care Coordination (I-TREC) program: scalable strategies for the management of hypertension and diabetes within the government healthcare system of India date: 2020-11-09 pages: extension: .txt txt: ./txt/cord-333142-ek7hct52.txt cache: ./cache/cord-333142-ek7hct52.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333142-ek7hct52.txt' === file2bib.sh === id: cord-335680-wsczl68g author: Brown, Charles A. title: Myocarditis and idiopathic dilated cardiomyopathy date: 1995-09-30 pages: extension: .txt txt: ./txt/cord-335680-wsczl68g.txt cache: ./cache/cord-335680-wsczl68g.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335680-wsczl68g.txt' === file2bib.sh === id: cord-336306-hvy9ukhh author: Zhu, Jieyun title: Clinical characteristics of 3,062 COVID‐19 patients: a meta‐analysis date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-336306-hvy9ukhh.txt cache: ./cache/cord-336306-hvy9ukhh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336306-hvy9ukhh.txt' === file2bib.sh === id: cord-335593-cjb0daps author: Romagnolo, Alberto title: Neurological comorbidity and severity of COVID-19 date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-335593-cjb0daps.txt cache: ./cache/cord-335593-cjb0daps.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335593-cjb0daps.txt' === file2bib.sh === id: cord-336258-dxps48bo author: Lee, Anne W.M. title: Advocacy to provide good quality oncology services during the COVID-19 pandemic – Actions at 3-Levels date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-336258-dxps48bo.txt cache: ./cache/cord-336258-dxps48bo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-336258-dxps48bo.txt' === file2bib.sh === id: cord-335095-epsi5qq7 author: Feng, Gong title: Clinical Features of COVID-19 Patients in Xiaogan City date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-335095-epsi5qq7.txt cache: ./cache/cord-335095-epsi5qq7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-335095-epsi5qq7.txt' === file2bib.sh === id: cord-335140-njg0ln33 author: Freeman, Ciara L title: Covid‐19 and Myeloma: what are the implications for now and in the future? date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-335140-njg0ln33.txt cache: ./cache/cord-335140-njg0ln33.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-335140-njg0ln33.txt' === file2bib.sh === id: cord-333749-45v6b4tc author: Xie, Guogang title: The role of peripheral blood eosinophil counts in COVID‐19 patients date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-333749-45v6b4tc.txt cache: ./cache/cord-333749-45v6b4tc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333749-45v6b4tc.txt' === file2bib.sh === id: cord-335338-wzxjn5ip author: Wei, Lan title: Pathology of the thyroid in severe acute respiratory syndrome() date: 2006-09-25 pages: extension: .txt txt: ./txt/cord-335338-wzxjn5ip.txt cache: ./cache/cord-335338-wzxjn5ip.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335338-wzxjn5ip.txt' === file2bib.sh === id: cord-335918-uc225mhn author: nan title: COVID-19 Guidance for Triage of Operations for Thoracic Malignancies: A Consensus Statement from Thoracic Surgery Outcomes Research Network date: 2020-04-09 pages: extension: .txt txt: ./txt/cord-335918-uc225mhn.txt cache: ./cache/cord-335918-uc225mhn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335918-uc225mhn.txt' === file2bib.sh === id: cord-335540-lahu5dno author: Granata, Tiziana title: Did the COVID‐19 pandemic silence the needs of people with epilepsy? date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-335540-lahu5dno.txt cache: ./cache/cord-335540-lahu5dno.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-335540-lahu5dno.txt' === file2bib.sh === id: cord-334835-j6u8t8j2 author: Berenguer, Juan title: Characteristics and predictors of death among 4,035 consecutively hospitalized patients with COVID-19 in Spain date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-334835-j6u8t8j2.txt cache: ./cache/cord-334835-j6u8t8j2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334835-j6u8t8j2.txt' === file2bib.sh === id: cord-336336-f01khqqr author: Singh, Rajat title: Therapeutic Strategy for Coronavirus Disease 2019 in Patients on Durable Left Ventricular Assist Device Support date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-336336-f01khqqr.txt cache: ./cache/cord-336336-f01khqqr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336336-f01khqqr.txt' === file2bib.sh === id: cord-336314-xf6zvvl8 author: Hu, Lijuan title: Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-336314-xf6zvvl8.txt cache: ./cache/cord-336314-xf6zvvl8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336314-xf6zvvl8.txt' === file2bib.sh === id: cord-336423-rs4bma9b author: Endersby, Ryan Vincent William title: Barrier Devices for Reducing Aerosol and Droplet Transmission in Coronavirus Disease 2019 Patients: Advantages, Disadvantages, and Alternative Solutions date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-336423-rs4bma9b.txt cache: ./cache/cord-336423-rs4bma9b.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336423-rs4bma9b.txt' === file2bib.sh === id: cord-334495-7y1la856 author: Agricola, Eustachio title: Heart and Lung Multimodality Imaging in COVID-19 date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-334495-7y1la856.txt cache: ./cache/cord-334495-7y1la856.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334495-7y1la856.txt' === file2bib.sh === id: cord-335465-sckfkciz author: Gupta, Rishi K. title: Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-335465-sckfkciz.txt cache: ./cache/cord-335465-sckfkciz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335465-sckfkciz.txt' === file2bib.sh === id: cord-336450-2ndan331 author: Shaw, Katharina S. title: Response to “Patient preference for cellulitis treatment: at-home care is preferred to hospital-based treatment” date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-336450-2ndan331.txt cache: ./cache/cord-336450-2ndan331.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336450-2ndan331.txt' === file2bib.sh === id: cord-335916-fh28qrt7 author: Liu, Cuiwei title: COVID-19 in cancer patients: risk, clinical features, and management date: 2020-08-15 pages: extension: .txt txt: ./txt/cord-335916-fh28qrt7.txt cache: ./cache/cord-335916-fh28qrt7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335916-fh28qrt7.txt' === file2bib.sh === id: cord-332992-8rmqg4rf author: de Vries, A. A. F. title: SARS-CoV-2/COVID-19: a primer for cardiologists date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-332992-8rmqg4rf.txt cache: ./cache/cord-332992-8rmqg4rf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-332992-8rmqg4rf.txt' === file2bib.sh === id: cord-335744-haj5a7tf author: Chibbaro, Salvatore title: How SARS-CoV-2 is forcing us to reconsider and reorganize our daily neurosurgical practice date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-335744-haj5a7tf.txt cache: ./cache/cord-335744-haj5a7tf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-335744-haj5a7tf.txt' === file2bib.sh === id: cord-335892-hwahcec5 author: Marshall, Elena title: Prevalence of hydroxychloroquine retinopathy using 2018 Royal College of Ophthalmologists diagnostic criteria date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-335892-hwahcec5.txt cache: ./cache/cord-335892-hwahcec5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-335892-hwahcec5.txt' === file2bib.sh === id: cord-336268-azgswke8 author: Porcel-Vazquez, Juan A. title: Usefulness of PCR Screening in the Initial Triage of Trauma Patients During COVID-19 Pandemic date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-336268-azgswke8.txt cache: ./cache/cord-336268-azgswke8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-336268-azgswke8.txt' === file2bib.sh === id: cord-021206-4zyqqgs0 author: nan title: Scientific and Educational Exhibits date: 2007 pages: extension: .txt txt: ./txt/cord-021206-4zyqqgs0.txt cache: ./cache/cord-021206-4zyqqgs0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-021206-4zyqqgs0.txt' === file2bib.sh === id: cord-336053-cjq7szcn author: Mottola, Filiberto Fausto title: Cardiovascular System in COVID-19: Simply a Viewer or a Leading Actor? date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-336053-cjq7szcn.txt cache: ./cache/cord-336053-cjq7szcn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-336053-cjq7szcn.txt' === file2bib.sh === id: cord-337094-aa3ourc6 author: Ramella, Vittorio title: Microsurgical reconstruction in the time of COVID‐19 date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-337094-aa3ourc6.txt cache: ./cache/cord-337094-aa3ourc6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337094-aa3ourc6.txt' === file2bib.sh === id: cord-337088-xxyhmn1t author: Malhotra, Naveen title: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement regarding COVID-19 date: 2020-03-28 pages: extension: .txt txt: ./txt/cord-337088-xxyhmn1t.txt cache: ./cache/cord-337088-xxyhmn1t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337088-xxyhmn1t.txt' === file2bib.sh === id: cord-336790-29im4gxw author: Violetis, Odyssefs A. title: COVID-19 Infection and Haematological Involvement: a Review of Epidemiology, Pathophysiology and Prognosis of Full Blood Count Findings date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-336790-29im4gxw.txt cache: ./cache/cord-336790-29im4gxw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336790-29im4gxw.txt' === file2bib.sh === id: cord-336368-sudi4mdx author: Thiruvenkatarajan, Venkatesan title: High-flow nasal cannula versus standard oxygen therapy assisting sedation during endoscopic retrograde cholangiopancreatography in high risk cases (OTHER): study protocol of a randomised multicentric trial date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-336368-sudi4mdx.txt cache: ./cache/cord-336368-sudi4mdx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-336368-sudi4mdx.txt' === file2bib.sh === id: cord-335795-hdko0zdw author: Wamsley, Christine E title: Trends and Challenges of Telehealth in an Academic Institution: The Unforeseen Benefits of the COVID-19 Global Pandemic date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-335795-hdko0zdw.txt cache: ./cache/cord-335795-hdko0zdw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335795-hdko0zdw.txt' === file2bib.sh === id: cord-335977-f00758o2 author: Martin-Loeches, I. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 pages: extension: .txt txt: ./txt/cord-335977-f00758o2.txt cache: ./cache/cord-335977-f00758o2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335977-f00758o2.txt' === file2bib.sh === id: cord-337115-vtjsigod author: Liao, Xuelian title: Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province, China date: 2020-02-05 pages: extension: .txt txt: ./txt/cord-337115-vtjsigod.txt cache: ./cache/cord-337115-vtjsigod.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337115-vtjsigod.txt' === file2bib.sh === id: cord-336390-ptnpgh3j author: Passamonti, Francesco title: Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-336390-ptnpgh3j.txt cache: ./cache/cord-336390-ptnpgh3j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336390-ptnpgh3j.txt' === file2bib.sh === id: cord-336621-0w3rroir author: Kim, Kyoung Ok title: A first step toward understanding patient safety date: 2016-07-25 pages: extension: .txt txt: ./txt/cord-336621-0w3rroir.txt cache: ./cache/cord-336621-0w3rroir.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336621-0w3rroir.txt' === file2bib.sh === id: cord-336462-7dltsav4 author: Trovik, Linn Hereide title: Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report date: 2020-11-11 pages: extension: .txt txt: ./txt/cord-336462-7dltsav4.txt cache: ./cache/cord-336462-7dltsav4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336462-7dltsav4.txt' === file2bib.sh === id: cord-336882-x9e6r0h0 author: Sambare, Tanmaya title: Preparing for an Era of Episode-Based Care in Total Joint Arthroplasty date: 2020-09-22 pages: extension: .txt txt: ./txt/cord-336882-x9e6r0h0.txt cache: ./cache/cord-336882-x9e6r0h0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336882-x9e6r0h0.txt' === file2bib.sh === id: cord-335265-kuc3v5m9 author: Elghazawy, Hagar title: Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-335265-kuc3v5m9.txt cache: ./cache/cord-335265-kuc3v5m9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335265-kuc3v5m9.txt' === file2bib.sh === id: cord-334773-yw2qgv13 author: Lisco, Giuseppe title: Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-334773-yw2qgv13.txt cache: ./cache/cord-334773-yw2qgv13.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-334773-yw2qgv13.txt' === file2bib.sh === id: cord-337262-88qpfu6b author: File, Thomas M. title: 26 Community-Acquired Pneumonia, Bacterial date: 2012-12-31 pages: extension: .txt txt: ./txt/cord-337262-88qpfu6b.txt cache: ./cache/cord-337262-88qpfu6b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-337262-88qpfu6b.txt' === file2bib.sh === id: cord-336438-mlgxiyur author: Huda, Farhanul title: Covid-19 and surgery: Challenging issues in the face of new normal – A narrative review date: 2020-10-23 pages: extension: .txt txt: ./txt/cord-336438-mlgxiyur.txt cache: ./cache/cord-336438-mlgxiyur.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336438-mlgxiyur.txt' === file2bib.sh === id: cord-337898-ncrbd8rp author: Pal, Rimesh title: Comment on “Is the type of diabetes treatment relevant to outcome of COVID‐19?” date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-337898-ncrbd8rp.txt cache: ./cache/cord-337898-ncrbd8rp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337898-ncrbd8rp.txt' === file2bib.sh === id: cord-337120-irpm5g7g author: Lee, Bruce Y. title: The Role of Internists During Epidemics, Outbreaks, and Bioterrorist Attacks date: 2007-01-13 pages: extension: .txt txt: ./txt/cord-337120-irpm5g7g.txt cache: ./cache/cord-337120-irpm5g7g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337120-irpm5g7g.txt' === file2bib.sh === id: cord-336395-v157jzvv author: Battaglini, Denise title: Chest physiotherapy: an important adjuvant in critically ill mechanically ventilated patients with COVID-19 date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-336395-v157jzvv.txt cache: ./cache/cord-336395-v157jzvv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336395-v157jzvv.txt' === file2bib.sh === id: cord-014794-yppi30a0 author: nan title: 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date: 2003-07-31 pages: extension: .txt txt: ./txt/cord-014794-yppi30a0.txt cache: ./cache/cord-014794-yppi30a0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-014794-yppi30a0.txt' === file2bib.sh === id: cord-337010-dgy7qbl5 author: Tomazini, B. M. title: COVID-19-associated ARDS treated with DEXamethasone (CoDEX): Study design and rationale for a randomized trial. date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-337010-dgy7qbl5.txt cache: ./cache/cord-337010-dgy7qbl5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337010-dgy7qbl5.txt' === file2bib.sh === id: cord-337520-qp0ga6q8 author: Binning, Mandy title: Cardiopulmonary resuscitation causing thoracolumbar hyperextension with severe spinal cord injury: A case report date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-337520-qp0ga6q8.txt cache: ./cache/cord-337520-qp0ga6q8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337520-qp0ga6q8.txt' === file2bib.sh === id: cord-337644-aobdzwpx author: Pianta, L. title: Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19 date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-337644-aobdzwpx.txt cache: ./cache/cord-337644-aobdzwpx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337644-aobdzwpx.txt' === file2bib.sh === id: cord-338968-b1gg2ha7 author: La Rosée, Felicitas title: Ruxolitinib in COVID-19 Hyperinflammation and Haematologic Malignancies date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-338968-b1gg2ha7.txt cache: ./cache/cord-338968-b1gg2ha7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-338968-b1gg2ha7.txt' === file2bib.sh === id: cord-337297-fkw8780t author: Fan, Siyuan title: Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-337297-fkw8780t.txt cache: ./cache/cord-337297-fkw8780t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337297-fkw8780t.txt' === file2bib.sh === id: cord-337338-7uj2r0gy author: Ohlstein, Jason F. title: Telemedicine in Otolaryngology in the COVID‐19 Era: Initial Lessons Learned date: 2020-08-02 pages: extension: .txt txt: ./txt/cord-337338-7uj2r0gy.txt cache: ./cache/cord-337338-7uj2r0gy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337338-7uj2r0gy.txt' === file2bib.sh === id: cord-336614-u6alc6rs author: Pérez-Belmonte, Luis M. title: Differences between Clinical Protocols for the Treatment of Coronavirus Disease 2019 (COVID-19) in Andalusia, Spain date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-336614-u6alc6rs.txt cache: ./cache/cord-336614-u6alc6rs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336614-u6alc6rs.txt' === file2bib.sh === id: cord-337906-qis8h3r3 author: Suresh Kumar, Vishnu Charan title: Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study date: 2020-09-27 pages: extension: .txt txt: ./txt/cord-337906-qis8h3r3.txt cache: ./cache/cord-337906-qis8h3r3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337906-qis8h3r3.txt' === file2bib.sh === id: cord-338362-6zwvkqag author: Cohen, Donald F. title: Ethical practice during the COVID-19 pandemic date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-338362-6zwvkqag.txt cache: ./cache/cord-338362-6zwvkqag.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-338362-6zwvkqag.txt' === file2bib.sh === id: cord-338146-am5gg1qd author: Bindi, E. title: Meckel's diverticulum perforation in a newborn positive to Sars-Cov-2 date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-338146-am5gg1qd.txt cache: ./cache/cord-338146-am5gg1qd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-338146-am5gg1qd.txt' === file2bib.sh === id: cord-337896-mct29erg author: Kornbluth, Asher title: Management of Inflammatory Bowel Disease and COVID-19 in New York City 2020: The Epicenter of IBD in the First Epicenter of the Global Pandemic date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-337896-mct29erg.txt cache: ./cache/cord-337896-mct29erg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-337896-mct29erg.txt' === file2bib.sh === id: cord-335597-anrzcsrt author: nan title: 44. Jahrestagung der Österreichischen Gesellschaft für Pneumologie date: 2020-10-26 pages: extension: .txt txt: ./txt/cord-335597-anrzcsrt.txt cache: ./cache/cord-335597-anrzcsrt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-335597-anrzcsrt.txt' === file2bib.sh === id: cord-338729-v2suoj3c author: Streicher, Caroline title: Could Tocilizumab be an Attractive Therapeutic Option for Elderly Patients with Severe COVID-19? A Case Report date: 2020-09-20 pages: extension: .txt txt: ./txt/cord-338729-v2suoj3c.txt cache: ./cache/cord-338729-v2suoj3c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338729-v2suoj3c.txt' === file2bib.sh === id: cord-339021-mhdaov1f author: Hong, Kyung Soo title: Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study date: 2020-05-01 pages: extension: .txt txt: ./txt/cord-339021-mhdaov1f.txt cache: ./cache/cord-339021-mhdaov1f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339021-mhdaov1f.txt' === file2bib.sh === id: cord-337995-z4rcczki author: Moris, Dimitrios title: Kidney Transplant Recipients Infected By COVID‐19: Review of the Initial Published Experience date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-337995-z4rcczki.txt cache: ./cache/cord-337995-z4rcczki.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-337995-z4rcczki.txt' === file2bib.sh === id: cord-336488-opjjowcq author: Kenanidis, Eustathios title: Organizing an Orthopaedic Department During COVID-19 Pandemic to Mitigate In-Hospital Transmission: Experience From Greece date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-336488-opjjowcq.txt cache: ./cache/cord-336488-opjjowcq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336488-opjjowcq.txt' === file2bib.sh === id: cord-337665-roelk7i5 author: Bhattacharjee, Hemanga K. title: Emergency Surgery during COVID-19: Lessons Learned date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-337665-roelk7i5.txt cache: ./cache/cord-337665-roelk7i5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337665-roelk7i5.txt' === file2bib.sh === id: cord-338135-zwo7e7gy author: Melis, Daniele title: Clinical efficacy, speed of improvement and safety of apremilast for the treatment of adult Psoriasis during COVID‐19 pandemic date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-338135-zwo7e7gy.txt cache: ./cache/cord-338135-zwo7e7gy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338135-zwo7e7gy.txt' === file2bib.sh === id: cord-336784-24qizp9k author: Robinson, Victoria A title: Validation of the Provincial Transfer Authorization Centre database: a comprehensive database containing records of all inter-facility patient transfers in the province of Ontario date: 2006-10-06 pages: extension: .txt txt: ./txt/cord-336784-24qizp9k.txt cache: ./cache/cord-336784-24qizp9k.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-336784-24qizp9k.txt' === file2bib.sh === id: cord-337622-rc9pejmo author: Sansom‐Daly, Ursula M. title: Grappling with the ‘human’ problem hiding behind the technology: Telehealth during and beyond COVID‐19 date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-337622-rc9pejmo.txt cache: ./cache/cord-337622-rc9pejmo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337622-rc9pejmo.txt' === file2bib.sh === id: cord-338668-z2z4gte2 author: Veraldi, Stefano title: Seborrheic dermatitis and masks date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-338668-z2z4gte2.txt cache: ./cache/cord-338668-z2z4gte2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338668-z2z4gte2.txt' === file2bib.sh === id: cord-338131-6y96eyoq author: Galvez, A. title: Perforated Marginal Ulcer in a COVID-19 Patient. Laparoscopy in these Trying Times? date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-338131-6y96eyoq.txt cache: ./cache/cord-338131-6y96eyoq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338131-6y96eyoq.txt' === file2bib.sh === id: cord-338192-2v9dbc9h author: Dai, J. D. title: How many patients will need ventilators tomorrow? date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-338192-2v9dbc9h.txt cache: ./cache/cord-338192-2v9dbc9h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338192-2v9dbc9h.txt' === file2bib.sh === id: cord-339015-qn8wbnlw author: Kayingo, Gerald title: Bacteria and Viruses: The Bogeymen in the Intensive Care Unit date: 2019-03-06 pages: extension: .txt txt: ./txt/cord-339015-qn8wbnlw.txt cache: ./cache/cord-339015-qn8wbnlw.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339015-qn8wbnlw.txt' === file2bib.sh === id: cord-337994-pkklt77i author: Brouqui, P. title: Remdesivir investigational trials in COVID-19: a critical reappraisal date: 2020-06-07 pages: extension: .txt txt: ./txt/cord-337994-pkklt77i.txt cache: ./cache/cord-337994-pkklt77i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337994-pkklt77i.txt' === file2bib.sh === id: cord-337302-fpz2jfuj author: Abdihamid, Omar title: The Landscape of COVID-19 in Cancer Patients: Prevalence, Impacts, and Recommendations date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-337302-fpz2jfuj.txt cache: ./cache/cord-337302-fpz2jfuj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337302-fpz2jfuj.txt' === file2bib.sh === id: cord-337926-6ddvqowr author: Farrell, Sarah title: Recommendations for the Care of Pediatric Orthopaedic Patients During the COVID Pandemic date: 2020-04-14 pages: extension: .txt txt: ./txt/cord-337926-6ddvqowr.txt cache: ./cache/cord-337926-6ddvqowr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337926-6ddvqowr.txt' === file2bib.sh === id: cord-336782-0zkb39v1 author: Fraile Gutiérrez, V. title: Narrative review of ultrasound in the management of the critically ill patient with SARS-CoV-2 infection (COVID-19): clinical applications in intensive care medicine date: 2020-11-02 pages: extension: .txt txt: ./txt/cord-336782-0zkb39v1.txt cache: ./cache/cord-336782-0zkb39v1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-336782-0zkb39v1.txt' === file2bib.sh === id: cord-339406-81a7fkpj author: Borghi, M. O. title: Prevalence, specificity, and clinical association of anti-phospholipid antibodies in COVID-19 patients: are the antibodies really guilty? date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-339406-81a7fkpj.txt cache: ./cache/cord-339406-81a7fkpj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339406-81a7fkpj.txt' === file2bib.sh === id: cord-339455-b8nu34vv author: Sakr, Yasser title: The clinical spectrum of pulmonary thromboembolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: A European case series date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-339455-b8nu34vv.txt cache: ./cache/cord-339455-b8nu34vv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339455-b8nu34vv.txt' === file2bib.sh === id: cord-336810-77wq9laa author: Klocperk, Adam title: Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19 date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-336810-77wq9laa.txt cache: ./cache/cord-336810-77wq9laa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336810-77wq9laa.txt' === file2bib.sh === id: cord-338346-e3fk6gz2 author: Oliveros, Estefania title: Coronavirus Disease 2019 and Heart Failure: A Multiparametric Approach date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-338346-e3fk6gz2.txt cache: ./cache/cord-338346-e3fk6gz2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338346-e3fk6gz2.txt' === file2bib.sh === id: cord-338602-6n309bnp author: Gadotti, Ana Carolina title: IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-338602-6n309bnp.txt cache: ./cache/cord-338602-6n309bnp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338602-6n309bnp.txt' === file2bib.sh === id: cord-339467-ewqxf02j author: Liang, Ying title: Differential diagnosis of coronavirus disease 2019 from pneumonias caused by other etiologies in a fever clinic in Beijing date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-339467-ewqxf02j.txt cache: ./cache/cord-339467-ewqxf02j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339467-ewqxf02j.txt' === file2bib.sh === id: cord-338605-3i5pvcgu author: Antoun, Lina title: Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome A prospective cohort study date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-338605-3i5pvcgu.txt cache: ./cache/cord-338605-3i5pvcgu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338605-3i5pvcgu.txt' === file2bib.sh === id: cord-338023-gb5jgqcg author: Obara, Shinju title: Anesthesiologist behavior and anesthesia machine use in the operating room during the COVID-19 pandemic: awareness and changes to cope with the risk of infection transmission date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-338023-gb5jgqcg.txt cache: ./cache/cord-338023-gb5jgqcg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-338023-gb5jgqcg.txt' === file2bib.sh === id: cord-337431-3rrvm787 author: Dimopoulos, G title: Viral Profile of COPD Exacerbations According to Patients§ date: 2015-02-23 pages: extension: .txt txt: ./txt/cord-337431-3rrvm787.txt cache: ./cache/cord-337431-3rrvm787.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337431-3rrvm787.txt' === file2bib.sh === id: cord-338683-nzgnpi6f author: Karligkiotis, Apostolos title: Changing paradigms in sinus and skull base surgery as the COVID‐19 pandemic evolves: Preliminary experience from a single Italian tertiary care center date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-338683-nzgnpi6f.txt cache: ./cache/cord-338683-nzgnpi6f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338683-nzgnpi6f.txt' === file2bib.sh === id: cord-338666-gg9qcpmz author: Rubin, Geoffrey A. title: Restructuring Electrophysiology During the COVID-19 Pandemic: A Practical Guide From a New York City Hospital Network date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-338666-gg9qcpmz.txt cache: ./cache/cord-338666-gg9qcpmz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-338666-gg9qcpmz.txt' === file2bib.sh === id: cord-338419-n8cmv8mf author: Carmelo, Juliana de Carvalho title: Impact of COVID-19 on the daily routine of radiology clinics date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-338419-n8cmv8mf.txt cache: ./cache/cord-338419-n8cmv8mf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338419-n8cmv8mf.txt' === file2bib.sh === id: cord-336543-ydrmlujj author: Cavalli, Eugenio title: Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review) date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-336543-ydrmlujj.txt cache: ./cache/cord-336543-ydrmlujj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336543-ydrmlujj.txt' === file2bib.sh === id: cord-339333-7tpnbr8q author: CHEN, YUXIAN title: Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults date: 2014-11-12 pages: extension: .txt txt: ./txt/cord-339333-7tpnbr8q.txt cache: ./cache/cord-339333-7tpnbr8q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339333-7tpnbr8q.txt' === file2bib.sh === id: cord-338600-wpfcxnyu author: Stewart, Cameron title: Mental Capacity Assessments for COVID-19 Patients: Emergency Admissions and the CARD Approach date: 2020-11-09 pages: extension: .txt txt: ./txt/cord-338600-wpfcxnyu.txt cache: ./cache/cord-338600-wpfcxnyu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-338600-wpfcxnyu.txt' === file2bib.sh === id: cord-338182-cetv78ba author: Zurita-Cruz, Jessie title: The Impact of a History of Pre-maturity on Viral Respiratory Infections in Children Under 2 Years of Age: A Propensity Score-Matching Analysis of in-hospital Complications and Mortality date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-338182-cetv78ba.txt cache: ./cache/cord-338182-cetv78ba.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338182-cetv78ba.txt' === file2bib.sh === id: cord-338900-8ojah695 author: MacDonald, David S. MacDonald title: Guidelines for Oral and Maxillofacial Imaging: COVID-19 Considerations date: 2020-10-26 pages: extension: .txt txt: ./txt/cord-338900-8ojah695.txt cache: ./cache/cord-338900-8ojah695.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338900-8ojah695.txt' === file2bib.sh === id: cord-337487-1lbopaso author: Hansildaar, Romy title: Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-337487-1lbopaso.txt cache: ./cache/cord-337487-1lbopaso.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337487-1lbopaso.txt' === file2bib.sh === id: cord-339267-p3djwg7v author: Taylor, Sally title: Exploring the experiences of patients, general practitioners and oncologists of prostate cancer follow-up: A qualitative interview study date: 2020-08-01 pages: extension: .txt txt: ./txt/cord-339267-p3djwg7v.txt cache: ./cache/cord-339267-p3djwg7v.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339267-p3djwg7v.txt' === file2bib.sh === id: cord-338756-jzz250o1 author: Zhang, Nan title: Epidemiologic and clinical characteristics of 42 deaths caused by SARS-CoV-2 infection in Wuhan, China: A retrospective study date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-338756-jzz250o1.txt cache: ./cache/cord-338756-jzz250o1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-338756-jzz250o1.txt' === file2bib.sh === id: cord-339568-th2xmhb6 author: Yan, Meitian title: Analysis of the diagnostic value of serum specific antibody testing for coronavirus disease 2019 date: 2020-06-27 pages: extension: .txt txt: ./txt/cord-339568-th2xmhb6.txt cache: ./cache/cord-339568-th2xmhb6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-339568-th2xmhb6.txt' === file2bib.sh === id: cord-336563-hwemigk7 author: Bhimraj, Adarsh title: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-336563-hwemigk7.txt cache: ./cache/cord-336563-hwemigk7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336563-hwemigk7.txt' === file2bib.sh === id: cord-339940-80757pwu author: Zaidi, S. Javed title: A novel approach to the diagnosis and treatment of hemoptysis in infants: A case series date: 2018-09-18 pages: extension: .txt txt: ./txt/cord-339940-80757pwu.txt cache: ./cache/cord-339940-80757pwu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339940-80757pwu.txt' === file2bib.sh === id: cord-339811-dms0rlmr author: Choudhury, Noura title: Training Oncologists in the Time of COVID‐19 date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-339811-dms0rlmr.txt cache: ./cache/cord-339811-dms0rlmr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-339811-dms0rlmr.txt' === file2bib.sh === id: cord-337965-z39q8ebq author: Kvernland, Alexandra title: Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-337965-z39q8ebq.txt cache: ./cache/cord-337965-z39q8ebq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-337965-z39q8ebq.txt' === file2bib.sh === id: cord-339471-1510mzmy author: Ikizler, T. Alp title: COVID-19 in Dialysis Patients: Adding a Few More Pieces to the Puzzle date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-339471-1510mzmy.txt cache: ./cache/cord-339471-1510mzmy.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-339471-1510mzmy.txt' === file2bib.sh === id: cord-336201-fl606l3b author: Daryabor, Gholamreza title: The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-336201-fl606l3b.txt cache: ./cache/cord-336201-fl606l3b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-336201-fl606l3b.txt' === file2bib.sh === id: cord-339266-glmshsh6 author: Yin, R. title: Clinical characteristics of 106 patients with neurological diseases and co-morbid coronavirus disease 2019: a retrospective study date: 2020-05-05 pages: extension: .txt txt: ./txt/cord-339266-glmshsh6.txt cache: ./cache/cord-339266-glmshsh6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339266-glmshsh6.txt' === file2bib.sh === id: cord-338517-1mxcssjj author: Ishay, Yuval title: Antibody response to SARS‐Co‐V‐2, diagnostic and therapeutic implications date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-338517-1mxcssjj.txt cache: ./cache/cord-338517-1mxcssjj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338517-1mxcssjj.txt' === file2bib.sh === id: cord-339589-dl2qpc0t author: Thachil, Jecko title: SARS-2 Coronavirus–Associated Hemostatic Lung Abnormality in COVID-19: Is It Pulmonary Thrombosis or Pulmonary Embolism? date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-339589-dl2qpc0t.txt cache: ./cache/cord-339589-dl2qpc0t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339589-dl2qpc0t.txt' === file2bib.sh === id: cord-339474-tsdq1rgz author: Rosen, Tony title: Managing Older Adults with Presumed COVID‐19 in the Emergency Department: A Rational Approach to Rationing date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-339474-tsdq1rgz.txt cache: ./cache/cord-339474-tsdq1rgz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339474-tsdq1rgz.txt' === file2bib.sh === id: cord-339044-qy4jab37 author: Li, Man title: Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-339044-qy4jab37.txt cache: ./cache/cord-339044-qy4jab37.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-339044-qy4jab37.txt' === file2bib.sh === id: cord-339517-93nuovsj author: Consolo, Ugo title: Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-339517-93nuovsj.txt cache: ./cache/cord-339517-93nuovsj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-339517-93nuovsj.txt' === file2bib.sh === id: cord-336554-n8n5ii5k author: Singh, Thakur Uttam title: Drug repurposing approach to fight COVID-19 date: 2020-09-05 pages: extension: .txt txt: ./txt/cord-336554-n8n5ii5k.txt cache: ./cache/cord-336554-n8n5ii5k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-336554-n8n5ii5k.txt' === file2bib.sh === id: cord-338965-ewuqsfsf author: Alotaibi, Fawzia E. title: Emergence of carbapenem-resistant Enterobacteriaceae isolated from patients in a university hospital in Saudi Arabia. Epidemiology, clinical profiles and outcomes date: 2017-06-20 pages: extension: .txt txt: ./txt/cord-338965-ewuqsfsf.txt cache: ./cache/cord-338965-ewuqsfsf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-338965-ewuqsfsf.txt' === file2bib.sh === id: cord-339913-ps4nvvaz author: Ma, Min title: How cardiologists respond to COVID-19: the experience of West China Hospital, China date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-339913-ps4nvvaz.txt cache: ./cache/cord-339913-ps4nvvaz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-339913-ps4nvvaz.txt' === file2bib.sh === id: cord-340204-3gm58qza author: Mahmoodpoor, Ata title: Management of Critically Ill Patients with COVID-19: What We Learned and What We Do date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-340204-3gm58qza.txt cache: ./cache/cord-340204-3gm58qza.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340204-3gm58qza.txt' === file2bib.sh === id: cord-340314-5oz3013n author: Mazzitelli, Maria title: Use of subcutaneous tocilizumab in patients with COVID‐19 pneumonia date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-340314-5oz3013n.txt cache: ./cache/cord-340314-5oz3013n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340314-5oz3013n.txt' === file2bib.sh === id: cord-338741-gy3ovkrt author: Sethi, Atin title: Evaluation of Current Therapies for COVID-19 Treatment date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-338741-gy3ovkrt.txt cache: ./cache/cord-338741-gy3ovkrt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-338741-gy3ovkrt.txt' === file2bib.sh === id: cord-339737-7qdjea6f author: Sbidian, E. title: Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-339737-7qdjea6f.txt cache: ./cache/cord-339737-7qdjea6f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339737-7qdjea6f.txt' === file2bib.sh === id: cord-340051-r9kn34wd author: MEI, Xue title: Observations about Symptomatic and Asymptomatic infections of 494 patients with COVID-19 in Shanghai,China date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-340051-r9kn34wd.txt cache: ./cache/cord-340051-r9kn34wd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-340051-r9kn34wd.txt' === file2bib.sh === id: cord-339355-zkkj8a83 author: Siripanthong, Bhurint title: Coronavirus disease 2019 is delaying the diagnosis and management of chest pain, acute coronary syndromes, myocarditis and heart failure date: 2020-07-01 pages: extension: .txt txt: ./txt/cord-339355-zkkj8a83.txt cache: ./cache/cord-339355-zkkj8a83.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339355-zkkj8a83.txt' === file2bib.sh === id: cord-340070-de7sfccy author: Pérez-Martinez, Antonio title: Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-340070-de7sfccy.txt cache: ./cache/cord-340070-de7sfccy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-340070-de7sfccy.txt' === file2bib.sh === id: cord-339679-9hghy9pd author: Gurley, Emily S. title: Person-to-Person Transmission of Nipah Virus in a Bangladeshi Community date: 2007-07-17 pages: extension: .txt txt: ./txt/cord-339679-9hghy9pd.txt cache: ./cache/cord-339679-9hghy9pd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-339679-9hghy9pd.txt' === file2bib.sh === id: cord-340660-ocvy1ge2 author: Mehmood, Maham A title: Methicillin-Resistant Staphylococcus Aureus: A Very Rare Cause of Meningitis date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-340660-ocvy1ge2.txt cache: ./cache/cord-340660-ocvy1ge2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340660-ocvy1ge2.txt' === file2bib.sh === id: cord-335802-1kiqfy68 author: Azoulay, Elie title: Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-335802-1kiqfy68.txt cache: ./cache/cord-335802-1kiqfy68.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335802-1kiqfy68.txt' === file2bib.sh === id: cord-340164-vzdyy656 author: Karimi, Zohreh title: The Lived Experience of Nurses Caring for Patients with COVID-19 in Iran: A Phenomenological Study date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-340164-vzdyy656.txt cache: ./cache/cord-340164-vzdyy656.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-340164-vzdyy656.txt' === file2bib.sh === id: cord-340383-psjga23p author: Simpson, Brenda Baird title: Patient Care Services Staffing Support During a Pandemic date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-340383-psjga23p.txt cache: ./cache/cord-340383-psjga23p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340383-psjga23p.txt' === file2bib.sh === id: cord-341415-g781zhu6 author: Jhaveri, Kenar D. title: Thrombotic microangiopathy in a patient with COVID-19 date: 2020-06-07 pages: extension: .txt txt: ./txt/cord-341415-g781zhu6.txt cache: ./cache/cord-341415-g781zhu6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-341415-g781zhu6.txt' === file2bib.sh === id: cord-340687-99ad1rwq author: Abourida, Yassamine title: Management of Severe COVID-19 in Pregnancy date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-340687-99ad1rwq.txt cache: ./cache/cord-340687-99ad1rwq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340687-99ad1rwq.txt' === file2bib.sh === id: cord-339504-8svo2w3u author: Lima, Rodrigo Moreira e title: Recommendations for local-regional anesthesia during the COVID-19 pandemic date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-339504-8svo2w3u.txt cache: ./cache/cord-339504-8svo2w3u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-339504-8svo2w3u.txt' === file2bib.sh === id: cord-340908-8q7i5ds3 author: D’Ambrosi, Riccardo title: Guidelines for Resuming Elective Hip and Knee Surgical Activity Following the COVID-19 Pandemic: An Italian Perspective date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-340908-8q7i5ds3.txt cache: ./cache/cord-340908-8q7i5ds3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340908-8q7i5ds3.txt' === file2bib.sh === id: cord-339436-0k73tlna author: Giagulli, Vito Angelo title: Worse progression of COVID‐19 in men: Is Testosterone a key factor? date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-339436-0k73tlna.txt cache: ./cache/cord-339436-0k73tlna.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339436-0k73tlna.txt' === file2bib.sh === id: cord-339009-wcoch07b author: File, Thomas M. title: Severe Acute Respiratory Syndrome: Pertinent Clinical Characteristics and Therapy date: 2012-08-23 pages: extension: .txt txt: ./txt/cord-339009-wcoch07b.txt cache: ./cache/cord-339009-wcoch07b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339009-wcoch07b.txt' === file2bib.sh === id: cord-341202-1pg7rq2d author: Manicone, Francesca title: The last bed dilemma burns out COVID-19 triage: a viewpoint from Medical and Law students date: 2020-08-12 pages: extension: .txt txt: ./txt/cord-341202-1pg7rq2d.txt cache: ./cache/cord-341202-1pg7rq2d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341202-1pg7rq2d.txt' === file2bib.sh === id: cord-339656-u0cpklsv author: de Groot-Mijnes, Jolanda D.F. title: Identification of New Pathogens in the Intraocular Fluid of Patients With Uveitis date: 2010-11-30 pages: extension: .txt txt: ./txt/cord-339656-u0cpklsv.txt cache: ./cache/cord-339656-u0cpklsv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339656-u0cpklsv.txt' === file2bib.sh === id: cord-339885-mpzgrogd author: Zhan, Yangqing title: Respiratory virus is a real pathogen in immunocompetent community-acquired pneumonia: comparing to influenza like illness and volunteer controls date: 2014-09-02 pages: extension: .txt txt: ./txt/cord-339885-mpzgrogd.txt cache: ./cache/cord-339885-mpzgrogd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339885-mpzgrogd.txt' === file2bib.sh === id: cord-336000-v88bq4bx author: Barco, Stefano title: Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-336000-v88bq4bx.txt cache: ./cache/cord-336000-v88bq4bx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-336000-v88bq4bx.txt' === file2bib.sh === id: cord-340430-x4oitcyh author: Horgan, T. J. title: Oral and Maxillofacial Surgery Patient Satisfaction with Telephone Consultations during the COVID-19 pandemic date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-340430-x4oitcyh.txt cache: ./cache/cord-340430-x4oitcyh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-340430-x4oitcyh.txt' === file2bib.sh === id: cord-342555-5r9aa7u5 author: Eghtesadi, Marzieh title: Breaking Social Isolation Amidst COVID‐19: A Viewpoint on Improving Access to Technology in Long‐Term Care Facilities date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-342555-5r9aa7u5.txt cache: ./cache/cord-342555-5r9aa7u5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342555-5r9aa7u5.txt' === file2bib.sh === id: cord-340000-1e66aqih author: Ho, Ivy K. title: The Role of Social Cognition in Medical Decision Making with Asian American Patients date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-340000-1e66aqih.txt cache: ./cache/cord-340000-1e66aqih.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340000-1e66aqih.txt' === file2bib.sh === id: cord-340811-w4x4falm author: Frizzelli, Annalisa title: What happens to people’s lungs when they get coronavirus disease 2019? date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-340811-w4x4falm.txt cache: ./cache/cord-340811-w4x4falm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340811-w4x4falm.txt' === file2bib.sh === id: cord-340542-jz7ca041 author: Lara Álvarez, Miguel Ángel title: Covid-19 mortality in cancer patients in a Madrid hospital during the first 3 weeks of the epidemic date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-340542-jz7ca041.txt cache: ./cache/cord-340542-jz7ca041.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340542-jz7ca041.txt' === file2bib.sh === id: cord-340651-g3518bq2 author: Hsu, Chung-Hua title: An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study date: 2007-05-29 pages: extension: .txt txt: ./txt/cord-340651-g3518bq2.txt cache: ./cache/cord-340651-g3518bq2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-340651-g3518bq2.txt' === file2bib.sh === id: cord-340826-2530zdeq author: Hwang, Jong-moon title: Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-340826-2530zdeq.txt cache: ./cache/cord-340826-2530zdeq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340826-2530zdeq.txt' === file2bib.sh === id: cord-341118-h5t87vf8 author: Torres‐Navarro, Ignacio title: A case of cefditoren‐induced Acute Generalized Exanthematous Pustulosis during COVID‐19 pandemics. Severe Cutaneous Adverse Reactions (SCARs) are an issue date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-341118-h5t87vf8.txt cache: ./cache/cord-341118-h5t87vf8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-341118-h5t87vf8.txt' === file2bib.sh === id: cord-340536-azlajqbe author: Bartolo, Michelangelo title: Urgent Measures for the Containment of the Coronavirus (Covid-19) Epidemic in the Neurorehabilitation/Rehabilitation Departments in the Phase of Maximum Expansion of the Epidemic date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-340536-azlajqbe.txt cache: ./cache/cord-340536-azlajqbe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340536-azlajqbe.txt' === file2bib.sh === id: cord-340766-aic570x8 author: Kim, Se Jin title: Outcomes of Early Administration of Cidofovir in Non-Immunocompromised Patients with Severe Adenovirus Pneumonia date: 2015-04-15 pages: extension: .txt txt: ./txt/cord-340766-aic570x8.txt cache: ./cache/cord-340766-aic570x8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-340766-aic570x8.txt' === file2bib.sh === id: cord-340232-cadu5ah8 author: Aliter, Kholoud F. title: Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19 date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-340232-cadu5ah8.txt cache: ./cache/cord-340232-cadu5ah8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-340232-cadu5ah8.txt' === file2bib.sh === id: cord-340415-6fte7krp author: Thevarajan, Irani title: Clinical presentation and management of COVID‐19 date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-340415-6fte7krp.txt cache: ./cache/cord-340415-6fte7krp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340415-6fte7krp.txt' === file2bib.sh === id: cord-339695-3ij5pjjy author: Nopp, Stephan title: Risk of venous thromboembolism in patients with COVID‐19: A systematic review and meta‐analysis date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-339695-3ij5pjjy.txt cache: ./cache/cord-339695-3ij5pjjy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-339695-3ij5pjjy.txt' === file2bib.sh === id: cord-339686-oybnk1j8 author: Suassuna, José Hermógenes Rocco title: Technical note and clinical instructions for Acute Kidney Injury (AKI) in patients with Covid-19: Brazilian Society of Nephrology and Brazilian Association of Intensive Care Medicine date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-339686-oybnk1j8.txt cache: ./cache/cord-339686-oybnk1j8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339686-oybnk1j8.txt' === file2bib.sh === id: cord-341627-21m8rdhy author: Buda, Natalia title: Lung ultrasound in the diagnosis of COVID-19 infection - A case series and review of the literature date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-341627-21m8rdhy.txt cache: ./cache/cord-341627-21m8rdhy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-341627-21m8rdhy.txt' === file2bib.sh === id: cord-341933-dwki1hwu author: Jeong, Han-Gil title: Therapeutic Temperature Modulation for a Critically Ill Patient with COVID-19 date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-341933-dwki1hwu.txt cache: ./cache/cord-341933-dwki1hwu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-341933-dwki1hwu.txt' === file2bib.sh === id: cord-342068-zhk3wmou author: Khazanie, Prateeti title: Forced Choices: Ethical Challenges in Cardiology During the COVID-19 Pandemic date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-342068-zhk3wmou.txt cache: ./cache/cord-342068-zhk3wmou.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342068-zhk3wmou.txt' === file2bib.sh === id: cord-340253-lpner9f8 author: D’Amario, Domenico title: Sex-Related Differences in Dilated Cardiomyopathy with a Focus on Cardiac Dysfunction in Oncology date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-340253-lpner9f8.txt cache: ./cache/cord-340253-lpner9f8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340253-lpner9f8.txt' === file2bib.sh === id: cord-339614-28s205p8 author: Dover, Jeffrey S. title: A Path to Resume Aesthetic Care: Executive Summary of Project AesCert Guidance Supplement—Practical Considerations for Aesthetic Medicine Professionals Supporting Clinic Preparedness in Response to the SARS-CoV-2 Outbreak date: 2020-05-01 pages: extension: .txt txt: ./txt/cord-339614-28s205p8.txt cache: ./cache/cord-339614-28s205p8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-339614-28s205p8.txt' === file2bib.sh === id: cord-340880-2qop8tcp author: Hyman, Jaime B. title: Timing of Intubation and In-Hospital Mortality in Patients With Coronavirus Disease 2019 date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-340880-2qop8tcp.txt cache: ./cache/cord-340880-2qop8tcp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340880-2qop8tcp.txt' === file2bib.sh === id: cord-341284-jmqdnart author: Panagopoulos, Periklis title: Lopinavir/ritonavir as a third agent in the antiviral regimen for SARS-CoV-2 infection date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-341284-jmqdnart.txt cache: ./cache/cord-341284-jmqdnart.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341284-jmqdnart.txt' === file2bib.sh === id: cord-339956-o5o2yz1u author: Albahri, O.S. title: Helping Doctors Hasten COVID-19 Treatment: Towards a Rescue Framework for the Transfusion of Best Convalescent Plasma to the Most Critical Patients based on Biological Requirements via ML and Novel MCDM Methods date: 2020-06-20 pages: extension: .txt txt: ./txt/cord-339956-o5o2yz1u.txt cache: ./cache/cord-339956-o5o2yz1u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-339956-o5o2yz1u.txt' === file2bib.sh === id: cord-341531-w788qwya author: Montero Feijoo, A. title: Practical recommendations for the perioperative management of patients with suspicion or serious infection by coronavirus SARS-CoV date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-341531-w788qwya.txt cache: ./cache/cord-341531-w788qwya.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341531-w788qwya.txt' === file2bib.sh === id: cord-343052-dc9s2rau author: Murgo, Salvatore title: Haemoptysis treated by bronchial artery embolisation in severe acute respiratory syndrome coronavirus 2: case report date: 2020-09-05 pages: extension: .txt txt: ./txt/cord-343052-dc9s2rau.txt cache: ./cache/cord-343052-dc9s2rau.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343052-dc9s2rau.txt' === file2bib.sh === id: cord-335141-ag3j8obh author: Higgins, G.C. title: FFP3 reusable respirators for COVID-19; adequate and suitable in the healthcare setting date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-335141-ag3j8obh.txt cache: ./cache/cord-335141-ag3j8obh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335141-ag3j8obh.txt' === file2bib.sh === id: cord-340984-blkhfhe2 author: Gklinos, Panagiotis title: Neurological manifestations of COVID-19: a review of what we know so far date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-340984-blkhfhe2.txt cache: ./cache/cord-340984-blkhfhe2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340984-blkhfhe2.txt' === file2bib.sh === id: cord-340650-mwsa326c author: Elangovan, E. J. title: Rationale and prognosis of repurposed drugs with risk stratification of patients in oxygen support in COVID-19: A systematic review and meta-analysis date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-340650-mwsa326c.txt cache: ./cache/cord-340650-mwsa326c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340650-mwsa326c.txt' === file2bib.sh === id: cord-341197-e8m4oxma author: Soleimani, Abbas title: Effects of angiotensin receptor blockers (ARBs) on in-hospital outcomes of patients with hypertension and confirmed or clinically suspected COVID-19 date: 2020-09-12 pages: extension: .txt txt: ./txt/cord-341197-e8m4oxma.txt cache: ./cache/cord-341197-e8m4oxma.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341197-e8m4oxma.txt' === file2bib.sh === id: cord-340786-12vzsl6p author: Pinto, Susana title: New technologies and Amyotrophic Lateral Sclerosis – Which step forward rushed by the COVID-19 pandemic? date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-340786-12vzsl6p.txt cache: ./cache/cord-340786-12vzsl6p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-340786-12vzsl6p.txt' === file2bib.sh === id: cord-340710-dmow5p7k author: Lagana, Stephen M. title: Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-340710-dmow5p7k.txt cache: ./cache/cord-340710-dmow5p7k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340710-dmow5p7k.txt' === file2bib.sh === id: cord-342810-41dghl0c author: Nguyen, Thanh N. title: Subarachnoid hemorrhage guidance in the era of the COVID-19 pandemic -An opinion to mitigate exposure and conserve personal protective equipment date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-342810-41dghl0c.txt cache: ./cache/cord-342810-41dghl0c.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342810-41dghl0c.txt' === file2bib.sh === id: cord-341314-1mav631s author: Caso, Valeria title: No lockdown for neurological diseases during COVID19 pandemic infection date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-341314-1mav631s.txt cache: ./cache/cord-341314-1mav631s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341314-1mav631s.txt' === file2bib.sh === id: cord-342857-vj6sw2ne author: McCullough, Peter A. title: Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-342857-vj6sw2ne.txt cache: ./cache/cord-342857-vj6sw2ne.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342857-vj6sw2ne.txt' === file2bib.sh === id: cord-341999-nosdj7b2 author: Conti, A. title: Evolution of COVID‐19 infection in 4 psoriatic patients treated with biological drugs date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-341999-nosdj7b2.txt cache: ./cache/cord-341999-nosdj7b2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-341999-nosdj7b2.txt' === file2bib.sh === id: cord-343308-5i31ysee author: Liu, Juan title: Detection of SARS‐CoV‐2 by RT‐PCR in anal from patients who have recovered from coronavirus disease 2019 date: 2020-04-14 pages: extension: .txt txt: ./txt/cord-343308-5i31ysee.txt cache: ./cache/cord-343308-5i31ysee.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-343308-5i31ysee.txt' === file2bib.sh === id: cord-342246-tnjtd9n3 author: Özçelik Korkmaz, Müge title: Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection date: 2020-10-03 pages: extension: .txt txt: ./txt/cord-342246-tnjtd9n3.txt cache: ./cache/cord-342246-tnjtd9n3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-342246-tnjtd9n3.txt' === file2bib.sh === id: cord-340576-dabcs3w5 author: Nishikawa, Hiroki title: Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-340576-dabcs3w5.txt cache: ./cache/cord-340576-dabcs3w5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-340576-dabcs3w5.txt' === file2bib.sh === id: cord-341076-ox2ckhqu author: Cenzato, Marco title: Editorial. Neurosurgery in the storm of COVID-19: suggestions from the Lombardy region, Italy (ex malo bonum) date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-341076-ox2ckhqu.txt cache: ./cache/cord-341076-ox2ckhqu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341076-ox2ckhqu.txt' === file2bib.sh === id: cord-341359-c34gyuv6 author: Larson, Derek T title: Clinical Outcomes of Coronavirus Disease 2019 With Evidence-based Supportive Care date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-341359-c34gyuv6.txt cache: ./cache/cord-341359-c34gyuv6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341359-c34gyuv6.txt' === file2bib.sh === id: cord-342303-ddulfe06 author: Ismael, Julia title: Multidisciplinary approach to COVID-19 and cancer: consensus from scientific societies in Argentina date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-342303-ddulfe06.txt cache: ./cache/cord-342303-ddulfe06.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-342303-ddulfe06.txt' === file2bib.sh === id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 pages: extension: .txt txt: ./txt/cord-005814-ak5pq312.txt cache: ./cache/cord-005814-ak5pq312.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-005814-ak5pq312.txt' === file2bib.sh === id: cord-340799-1awmtj52 author: Krajewska, Joanna title: Review of practical recommendations for otolaryngologists and head and neck surgeons during the COVID-19 pandemic: Recommendations for otolaryngologists during the COVID-19 pandemic date: 2020-06-06 pages: extension: .txt txt: ./txt/cord-340799-1awmtj52.txt cache: ./cache/cord-340799-1awmtj52.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340799-1awmtj52.txt' === file2bib.sh === id: cord-340857-teq5txm9 author: Galloro, Giuseppe title: SAFETY IN DIGESTIVE ENDOSCOPY PROCEDURES IN THE COVID ERA RECOMMENDATIONS IN PROGRES OF THE ITALIAN SOCIETY OF DIGESTIVE ENDOSCOPY date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-340857-teq5txm9.txt cache: ./cache/cord-340857-teq5txm9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-340857-teq5txm9.txt' === file2bib.sh === id: cord-342808-yonbowkb author: Francque, Sven title: Innovative liver research continues during the current pandemic date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-342808-yonbowkb.txt cache: ./cache/cord-342808-yonbowkb.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342808-yonbowkb.txt' === file2bib.sh === id: cord-342569-ja96xfns author: Azer, Samy A. title: COVID-19: Pathophysiology, diagnosis, complications and Investigational therapeutics date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-342569-ja96xfns.txt cache: ./cache/cord-342569-ja96xfns.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342569-ja96xfns.txt' === file2bib.sh === id: cord-341234-2zgfcrwc author: Hallak, Jorge title: Concise practice recommendations for the provision of andrological services and assisted reproductive technology for male infertility patients during the SARS-CoV-2 in Brazil date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-341234-2zgfcrwc.txt cache: ./cache/cord-341234-2zgfcrwc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341234-2zgfcrwc.txt' === file2bib.sh === id: cord-341670-o1v63zg8 author: Estevez-Ordonez, Dagoberto title: Letter: Perioperative and Critical Care Management of a Patient With Severe Acute Respiratory Syndrome Corona Virus 2 Infection and Aneurysmal Subarachnoid Hemorrhage date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-341670-o1v63zg8.txt cache: ./cache/cord-341670-o1v63zg8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341670-o1v63zg8.txt' === file2bib.sh === id: cord-343393-8hdygwip author: Kudsi, Omar Yusef title: Robotic Low Anterior Resection for a Distal Sigmoid Colon Cancer during the COVID‐19 Pandemic – a Video Vignette date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-343393-8hdygwip.txt cache: ./cache/cord-343393-8hdygwip.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-343393-8hdygwip.txt' === file2bib.sh === id: cord-343201-98scxky8 author: Thibault, Ronan title: How the Covid-19 epidemic is challenging our practice in clinical nutrition—feedback from the field date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-343201-98scxky8.txt cache: ./cache/cord-343201-98scxky8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343201-98scxky8.txt' === file2bib.sh === id: cord-342519-tjr6dvtt author: Souza, Thiago Moreno L. title: H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis date: 2010-11-30 pages: extension: .txt txt: ./txt/cord-342519-tjr6dvtt.txt cache: ./cache/cord-342519-tjr6dvtt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342519-tjr6dvtt.txt' === file2bib.sh === id: cord-343490-94vkfrtw author: Handaya, Adeodatus Yuda title: Covid-19 mimicking symptoms in emergency gastrointestinal surgery cases during pandemic: a case series date: 2020-10-24 pages: extension: .txt txt: ./txt/cord-343490-94vkfrtw.txt cache: ./cache/cord-343490-94vkfrtw.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-343490-94vkfrtw.txt' === file2bib.sh === id: cord-342451-yfy5jcw6 author: Rigamonti, Andrea title: Cerebral venous thrombosis associated with coronavirus infection: an underestimated entity? date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-342451-yfy5jcw6.txt cache: ./cache/cord-342451-yfy5jcw6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-342451-yfy5jcw6.txt' === file2bib.sh === id: cord-342139-t2tukk0z author: Livingston, Gill title: Prevalence, management, and outcomes of SARS-CoV-2 infections in older people and those with dementia in mental health wards in London, UK: a retrospective observational study date: 2020-10-05 pages: extension: .txt txt: ./txt/cord-342139-t2tukk0z.txt cache: ./cache/cord-342139-t2tukk0z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342139-t2tukk0z.txt' === file2bib.sh === id: cord-343023-e1uv7t6p author: Zhang, Jingchen title: Failure of early extubation among cases of coronavirus disease-19 respiratory failure: Case report and clinical experience date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-343023-e1uv7t6p.txt cache: ./cache/cord-343023-e1uv7t6p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343023-e1uv7t6p.txt' === file2bib.sh === id: cord-343443-ljehete1 author: Kissling, Sébastien title: Collapsing glomerulopathy in a COVID-19 patient. date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-343443-ljehete1.txt cache: ./cache/cord-343443-ljehete1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343443-ljehete1.txt' === file2bib.sh === id: cord-342930-f7cw2ca6 author: Portincasa, Piero title: Hepatic consequences of COVID-19 infection. Lapping or biting? date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-342930-f7cw2ca6.txt cache: ./cache/cord-342930-f7cw2ca6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342930-f7cw2ca6.txt' === file2bib.sh === id: cord-343743-6k3soh1l author: Chaudhary, Sachin title: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-343743-6k3soh1l.txt cache: ./cache/cord-343743-6k3soh1l.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-343743-6k3soh1l.txt' === file2bib.sh === id: cord-341919-8gnthufw author: Basi, Saajan title: Clinical course of a 66-year-old man with an acute ischaemic stroke in the setting of a COVID-19 infection date: 2020-08-23 pages: extension: .txt txt: ./txt/cord-341919-8gnthufw.txt cache: ./cache/cord-341919-8gnthufw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-341919-8gnthufw.txt' === file2bib.sh === id: cord-342979-pvewvmmf author: Martínez-del Río, Jorge title: Comparative analysis between the use of renin-angiotensin system antagonists and clinical outcomes of hospitalized patients with COVID-19 respiratory infection date: 2020-11-12 pages: extension: .txt txt: ./txt/cord-342979-pvewvmmf.txt cache: ./cache/cord-342979-pvewvmmf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-342979-pvewvmmf.txt' === file2bib.sh === id: cord-342809-wrxejwms author: Song, Jungeun title: Characteristics of First Visit Pediatric Patients with Suicidal Ideation and Behavior: An 8-Year Retrospective Chart Review date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-342809-wrxejwms.txt cache: ./cache/cord-342809-wrxejwms.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-342809-wrxejwms.txt' === file2bib.sh === id: cord-342841-b1rucgmg author: Di Carlo, Francesco title: Telepsychiatry and other cutting edge technologies in Covid‐19 pandemic: bridging the distance in mental health assistance date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-342841-b1rucgmg.txt cache: ./cache/cord-342841-b1rucgmg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342841-b1rucgmg.txt' === file2bib.sh === id: cord-343797-kpmz5kwg author: Lee, Martin Beng‐Huat title: GOING TO WAR ON COVID19: MOBILIZING AN ACADEMIC NEPHROLOGY GROUP PRACTICE date: 2020-07-04 pages: extension: .txt txt: ./txt/cord-343797-kpmz5kwg.txt cache: ./cache/cord-343797-kpmz5kwg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343797-kpmz5kwg.txt' === file2bib.sh === id: cord-344104-592r71l1 author: Ardati, Amer K. title: Be Prepared date: 2020-03-17 pages: extension: .txt txt: ./txt/cord-344104-592r71l1.txt cache: ./cache/cord-344104-592r71l1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344104-592r71l1.txt' === file2bib.sh === id: cord-344004-z7pn7u6u author: Shaha, Ashok R. title: Thyroid surgery during COVID‐19 pandemic: Principles and philosophies date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-344004-z7pn7u6u.txt cache: ./cache/cord-344004-z7pn7u6u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344004-z7pn7u6u.txt' === file2bib.sh === id: cord-343819-1uki4b3d author: Mian, Muhammad S title: Pathological Findings and Management of COVID-19 Patients: A Brief Overview of Modern-day Pandemic date: 2020-05-15 pages: extension: .txt txt: ./txt/cord-343819-1uki4b3d.txt cache: ./cache/cord-343819-1uki4b3d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-343819-1uki4b3d.txt' === file2bib.sh === id: cord-343773-9f7ew8uj author: Volo, T. title: Elective tracheostomy during COVID-19 outbreak: to whom, when, how? Early experience from Venice, Italy date: 2020-07-12 pages: extension: .txt txt: ./txt/cord-343773-9f7ew8uj.txt cache: ./cache/cord-343773-9f7ew8uj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343773-9f7ew8uj.txt' === file2bib.sh === id: cord-343973-n5ogyxz7 author: Ip, Andrew title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-343973-n5ogyxz7.txt cache: ./cache/cord-343973-n5ogyxz7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343973-n5ogyxz7.txt' === file2bib.sh === id: cord-344765-agt60ksx author: Bhogal, R.H. title: Approach to upper GastroIntestinal cancer surgery during the COVID-19 pandemic – Experience from a UK cancer centre date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-344765-agt60ksx.txt cache: ./cache/cord-344765-agt60ksx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-344765-agt60ksx.txt' === file2bib.sh === id: cord-342603-k0f33p3l author: Spyropoulos, Alex C. title: Scientific and Standardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID‐19 date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-342603-k0f33p3l.txt cache: ./cache/cord-342603-k0f33p3l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-342603-k0f33p3l.txt' === file2bib.sh === id: cord-344389-aj9q73f0 author: Brosnahan, Shari B. title: COVID-19 Pneumonia Hospitalizations Followed by Re-presentation for Presumed Thrombotic Event date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-344389-aj9q73f0.txt cache: ./cache/cord-344389-aj9q73f0.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344389-aj9q73f0.txt' === file2bib.sh === id: cord-343876-2inr4mcy author: Xie, Qin title: COVID-19 patients managed in psychiatric inpatient settings due to first-episode mental disorders in Wuhan, China: clinical characteristics, treatments, outcomes, and our experiences date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-343876-2inr4mcy.txt cache: ./cache/cord-343876-2inr4mcy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343876-2inr4mcy.txt' === file2bib.sh === id: cord-344191-veug3dae author: Weiling, Lydia Li title: Digital health for patients with chronic pain during the COVID-19 pandemic date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-344191-veug3dae.txt cache: ./cache/cord-344191-veug3dae.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-344191-veug3dae.txt' === file2bib.sh === id: cord-342786-dl8vjwfn author: Sattar, Yasar title: COVID-19 Cardiovascular Epidemiology, Cellular Pathogenesis, Clinical Manifestations and Management date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-342786-dl8vjwfn.txt cache: ./cache/cord-342786-dl8vjwfn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-342786-dl8vjwfn.txt' === file2bib.sh === id: cord-343917-67qjqxqh author: Dabrowska, Dominika title: Staying Ahead of the Curve: Modified Approach to Emergency Caesarean Section Under General Anaesthesia in COVID-19 Pandemic date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-343917-67qjqxqh.txt cache: ./cache/cord-343917-67qjqxqh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343917-67qjqxqh.txt' === file2bib.sh === id: cord-344271-5aynmdsk author: de Souza Luna, Luciano Kleber title: Spectrum of Viruses and Atypical Bacteria in Intercontinental Air Travelers with Symptoms of Acute Respiratory Infection date: 2007-03-01 pages: extension: .txt txt: ./txt/cord-344271-5aynmdsk.txt cache: ./cache/cord-344271-5aynmdsk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344271-5aynmdsk.txt' === file2bib.sh === id: cord-344135-pyibu6rj author: Zuo, Peiyuan title: Decreased prealbumin level is associated with increased risk of mortality in hospitalized elderly patients with COVID-19 date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-344135-pyibu6rj.txt cache: ./cache/cord-344135-pyibu6rj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344135-pyibu6rj.txt' === file2bib.sh === id: cord-343452-4m0ub9iv author: Barkama, Ravit title: Placenta-Derived Cell Therapy to Treat Patients With Respiratory Failure Due to Coronavirus Disease 2019 date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-343452-4m0ub9iv.txt cache: ./cache/cord-343452-4m0ub9iv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343452-4m0ub9iv.txt' === file2bib.sh === id: cord-343832-xg3swuzs author: Pugliese, Daniela title: The management of Inflammatory Bowel Diseases in the era of COVID-19 pandemic: when “non-urgent” does not mean “deferrable” date: 2020-06-18 pages: extension: .txt txt: ./txt/cord-343832-xg3swuzs.txt cache: ./cache/cord-343832-xg3swuzs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-343832-xg3swuzs.txt' === file2bib.sh === id: cord-343566-epvswt7f author: Wang, Zhao-Hua title: Critically Ill Patients with Coronavirus Disease 2019 in a Designated ICU: Clinical Features and Predictors for Mortality date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-343566-epvswt7f.txt cache: ./cache/cord-343566-epvswt7f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343566-epvswt7f.txt' === file2bib.sh === id: cord-344185-jz6ui4w3 author: Aziz, Aleha title: Building an Obstetric Intensive Care Unit during the COVID-19 Pandemic at a Tertiary Hospital and Selected Maternal-Fetal and Delivery Considerations date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-344185-jz6ui4w3.txt cache: ./cache/cord-344185-jz6ui4w3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344185-jz6ui4w3.txt' === file2bib.sh === id: cord-343877-jzkaee16 author: Newdick, Chris title: Tragic choices in intensive care during the COVID-19 pandemic: on fairness, consistency and community date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-343877-jzkaee16.txt cache: ./cache/cord-343877-jzkaee16.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-343877-jzkaee16.txt' === file2bib.sh === id: cord-344668-9m1vnpmo author: Nitkunan, Arani title: COVID-19: switching to remote neurology outpatient consultations date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-344668-9m1vnpmo.txt cache: ./cache/cord-344668-9m1vnpmo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344668-9m1vnpmo.txt' === file2bib.sh === id: cord-344508-a67vsux2 author: Campanile, Fabio Cesare title: Acute cholecystitis during COVID-19 pandemic: a multisocietary position statement date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-344508-a67vsux2.txt cache: ./cache/cord-344508-a67vsux2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344508-a67vsux2.txt' === file2bib.sh === id: cord-344117-lr6roxej author: Vieira, Ana Luisa Silveira title: Role of point-of-care ultrasound during the COVID-19 pandemic: our recommendations in the management of dialytic patients date: 2020-06-03 pages: extension: .txt txt: ./txt/cord-344117-lr6roxej.txt cache: ./cache/cord-344117-lr6roxej.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344117-lr6roxej.txt' === file2bib.sh === id: cord-344939-rgxqobfw author: Ng, C. W. Q. title: Maintaining breast cancer care in the face of COVID‐19 date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-344939-rgxqobfw.txt cache: ./cache/cord-344939-rgxqobfw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-344939-rgxqobfw.txt' === file2bib.sh === id: cord-344270-874i31h8 author: Radke, Robert M title: Adult congenital heart disease and the COVID-19 pandemic date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-344270-874i31h8.txt cache: ./cache/cord-344270-874i31h8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344270-874i31h8.txt' === file2bib.sh === id: cord-344302-p0v6sl9x author: Gubitosa, James C title: COVID-19-Associated Acute Limb Ischemia in a Patient on Therapeutic Anticoagulation date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-344302-p0v6sl9x.txt cache: ./cache/cord-344302-p0v6sl9x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344302-p0v6sl9x.txt' === file2bib.sh === id: cord-345445-9t1vebey author: Radmanesh, Alireza title: COVID-19–associated Diffuse Leukoencephalopathy and Microhemorrhages date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-345445-9t1vebey.txt cache: ./cache/cord-345445-9t1vebey.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345445-9t1vebey.txt' === file2bib.sh === id: cord-006854-o2e5na78 author: nan title: Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date: 2018-04-20 pages: extension: .txt txt: ./txt/cord-006854-o2e5na78.txt cache: ./cache/cord-006854-o2e5na78.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-006854-o2e5na78.txt' === file2bib.sh === id: cord-341591-ib8lsvku author: Simpson, J. Keith title: Informed consent, duty of disclosure and chiropractic: where are we? date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-341591-ib8lsvku.txt cache: ./cache/cord-341591-ib8lsvku.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-341591-ib8lsvku.txt' === file2bib.sh === id: cord-345517-ji4cet51 author: Duarte de Araújo, António Manuel Silva title: Copd: will there be room for nebulisers after the current covid-19 pandemic? date: 2020-09-16 pages: extension: .txt txt: ./txt/cord-345517-ji4cet51.txt cache: ./cache/cord-345517-ji4cet51.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-345517-ji4cet51.txt' === file2bib.sh === id: cord-343437-cz1w9od9 author: Kahaly, George J title: Management of Graves‘Thyroidal And Extrathyroidal Disease – An Update date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-343437-cz1w9od9.txt cache: ./cache/cord-343437-cz1w9od9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343437-cz1w9od9.txt' === file2bib.sh === id: cord-335382-fk4um9nw author: Farver, Carol F. title: Molecular Basis of Pulmonary Disease date: 2012-08-10 pages: extension: .txt txt: ./txt/cord-335382-fk4um9nw.txt cache: ./cache/cord-335382-fk4um9nw.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-335382-fk4um9nw.txt' === file2bib.sh === id: cord-344693-znw3dru4 author: Lima, Brian title: COVID‐19 in recent heart transplant recipients: Clinicopathologic features and early outcomes date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-344693-znw3dru4.txt cache: ./cache/cord-344693-znw3dru4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-344693-znw3dru4.txt' === file2bib.sh === id: cord-344017-qldawc8m author: Edouard, S. title: Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France date: 2020-11-11 pages: extension: .txt txt: ./txt/cord-344017-qldawc8m.txt cache: ./cache/cord-344017-qldawc8m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344017-qldawc8m.txt' === file2bib.sh === id: cord-344729-sjjedgws author: Bhaskar, Sonu title: Acute Neurological Care in the COVID-19 Era: The Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium Pathway date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-344729-sjjedgws.txt cache: ./cache/cord-344729-sjjedgws.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344729-sjjedgws.txt' === file2bib.sh === id: cord-345028-56hg62be author: Flinspach, Armin Niklas title: Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients—A Case Series and Systematic Review date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-345028-56hg62be.txt cache: ./cache/cord-345028-56hg62be.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345028-56hg62be.txt' === file2bib.sh === id: cord-343715-y594iewi author: Gavriatopoulou, Maria title: Organ-specific manifestations of COVID-19 infection date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-343715-y594iewi.txt cache: ./cache/cord-343715-y594iewi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-343715-y594iewi.txt' === file2bib.sh === id: cord-344709-5hy1e4t1 author: Patel, Brijesh V. title: Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-344709-5hy1e4t1.txt cache: ./cache/cord-344709-5hy1e4t1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344709-5hy1e4t1.txt' === file2bib.sh === id: cord-344120-7t5ce2hb author: Baroutjian, Amanda title: SARS-CoV-2 pharmacologic therapies and their safety/effectiveness according to level of evidence date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-344120-7t5ce2hb.txt cache: ./cache/cord-344120-7t5ce2hb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-344120-7t5ce2hb.txt' === file2bib.sh === id: cord-344967-t88pedeb author: Tang, Hon Lok title: Severe acute respiratory syndrome in haemodialysis patients: a report of two cases date: 2003-10-17 pages: extension: .txt txt: ./txt/cord-344967-t88pedeb.txt cache: ./cache/cord-344967-t88pedeb.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344967-t88pedeb.txt' === file2bib.sh === id: cord-015359-gf32a6f1 author: nan title: B scientific sessions (SS) date: 2002 pages: extension: .txt txt: ./txt/cord-015359-gf32a6f1.txt cache: ./cache/cord-015359-gf32a6f1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 14 resourceName b'cord-015359-gf32a6f1.txt' === file2bib.sh === id: cord-345860-d02x3151 author: Thome, Johannes title: The impact of the COVID-19 outbreak on the medico-legal and human rights of psychiatric patients date: 2020-05-29 pages: extension: .txt txt: ./txt/cord-345860-d02x3151.txt cache: ./cache/cord-345860-d02x3151.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-345860-d02x3151.txt' === file2bib.sh === id: cord-345680-10phij1x author: Terpos, Evangelos title: Hematological findings and complications of COVID‐19 date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-345680-10phij1x.txt cache: ./cache/cord-345680-10phij1x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345680-10phij1x.txt' === file2bib.sh === id: cord-339705-x8l3zgfd author: Patil, Vijaykumar title: An association between fingerprint patterns with blood group and lifestyle based diseases: a review date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-339705-x8l3zgfd.txt cache: ./cache/cord-339705-x8l3zgfd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339705-x8l3zgfd.txt' === file2bib.sh === id: cord-343970-anocx4y1 author: Bansal, Rashika title: Metabolic Syndrome and COVID 19: Endocrine-Immune-Vascular Interactions Shapes Clinical Course date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-343970-anocx4y1.txt cache: ./cache/cord-343970-anocx4y1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-343970-anocx4y1.txt' === file2bib.sh === id: cord-345296-4z7yfj5s author: Ho, Mei-Shang title: Neutralizing Antibody Response and SARS Severity date: 2005-11-17 pages: extension: .txt txt: ./txt/cord-345296-4z7yfj5s.txt cache: ./cache/cord-345296-4z7yfj5s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345296-4z7yfj5s.txt' === file2bib.sh === id: cord-343205-zjw4fbfd author: Bhaskar, Sonu title: Telemedicine as the New Outpatient Clinic Gone Digital: Position Paper From the Pandemic Health System REsilience PROGRAM (REPROGRAM) International Consortium (Part 2) date: 2020-09-07 pages: extension: .txt txt: ./txt/cord-343205-zjw4fbfd.txt cache: ./cache/cord-343205-zjw4fbfd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-343205-zjw4fbfd.txt' === file2bib.sh === id: cord-345632-iha2c5zo author: Hamdy, Sherif M title: Management Strategies of Patients with Neuromyelitis Optica Spectrum Disorder During the COVID-19 Pandemic Era date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-345632-iha2c5zo.txt cache: ./cache/cord-345632-iha2c5zo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-345632-iha2c5zo.txt' === file2bib.sh === id: cord-346061-pbghgitg author: Passanisi, Stefano title: Quarantine Due to the COVID-19 Pandemic From the Perspective of Pediatric Patients With Type 1 Diabetes: A Web-Based Survey date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-346061-pbghgitg.txt cache: ./cache/cord-346061-pbghgitg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346061-pbghgitg.txt' === file2bib.sh === id: cord-345779-frspku51 author: Pinto, Antonio title: Interventional radiology in gynaecology and obstetric practice: safety issues date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-345779-frspku51.txt cache: ./cache/cord-345779-frspku51.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345779-frspku51.txt' === file2bib.sh === id: cord-345381-9cckppk2 author: Klimek, Ludger title: Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)(A), Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)(B), Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)(C), Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)(D), Luxemburgische Gesellschaft für Allergologie und Immunologie (LGAI)(E), Österreichische Gesellschaft für Pneumologie (ÖGP)(F) in co-operation with the German, Austrian, and Swiss ARIA groups(G), and the European Academy of Allergy and Clinical Immunology (EAACI)(H) date: 2020-09-07 pages: extension: .txt txt: ./txt/cord-345381-9cckppk2.txt cache: ./cache/cord-345381-9cckppk2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345381-9cckppk2.txt' === file2bib.sh === id: cord-345762-khvcoqti author: Scott, Ian A. title: COVID‐19 pandemic and the tension between the need to act and the need to know date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-345762-khvcoqti.txt cache: ./cache/cord-345762-khvcoqti.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-345762-khvcoqti.txt' === file2bib.sh === id: cord-344431-2wq7msqz author: Holzinger, Felix title: Self-referred walk-in patients in the emergency department – who and why? Consultation determinants in a multicenter study of respiratory patients in Berlin, Germany date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-344431-2wq7msqz.txt cache: ./cache/cord-344431-2wq7msqz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344431-2wq7msqz.txt' === file2bib.sh === id: cord-345628-a4c46m2w author: Unudurthi, Sathya D. title: Cardiac inflammation in COVID-19: Lessons from heart failure date: 2020-09-21 pages: extension: .txt txt: ./txt/cord-345628-a4c46m2w.txt cache: ./cache/cord-345628-a4c46m2w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-345628-a4c46m2w.txt' === file2bib.sh === id: cord-345655-fb4vv4my author: Islam, M. Z. title: Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28th day of the disease course: a retrospective cohort study in Bangladesh date: 2020-10-29 pages: extension: .txt txt: ./txt/cord-345655-fb4vv4my.txt cache: ./cache/cord-345655-fb4vv4my.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345655-fb4vv4my.txt' === file2bib.sh === id: cord-345044-2fez1gu0 author: Proenca‐Modena, José Luiz title: Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children date: 2019-03-18 pages: extension: .txt txt: ./txt/cord-345044-2fez1gu0.txt cache: ./cache/cord-345044-2fez1gu0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-345044-2fez1gu0.txt' === file2bib.sh === id: cord-344486-iu5flbcl author: Chiotos, Kathleen title: Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2 date: 2020-09-12 pages: extension: .txt txt: ./txt/cord-344486-iu5flbcl.txt cache: ./cache/cord-344486-iu5flbcl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344486-iu5flbcl.txt' === file2bib.sh === id: cord-345611-xv62h83a author: Cavalcanti, A. B. title: Hydroxychloroquine alone or in combination with azithromycin to prevent major clinical events in hospitalised patients with coronavirus infection (COVID-19): rationale and design of a randomised, controlled clinical trial date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-345611-xv62h83a.txt cache: ./cache/cord-345611-xv62h83a.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345611-xv62h83a.txt' === file2bib.sh === id: cord-343897-f4imrltt author: Weimer, Louis H. title: Neuromuscular disorders in pregnancy date: 2020-08-04 pages: extension: .txt txt: ./txt/cord-343897-f4imrltt.txt cache: ./cache/cord-343897-f4imrltt.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343897-f4imrltt.txt' === file2bib.sh === id: cord-345727-bcxkycjh author: Karimata, Yosuke title: Clinical Features of Human Metapneumovirus Pneumonia in Non-Immunocompromised Patients: An Investigation of Three Long-Term Care Facility Outbreaks date: 2018-09-15 pages: extension: .txt txt: ./txt/cord-345727-bcxkycjh.txt cache: ./cache/cord-345727-bcxkycjh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345727-bcxkycjh.txt' === file2bib.sh === id: cord-346345-jc9bq0zu author: Smith, Colin M title: COVID-19-associated brief psychotic disorder date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-346345-jc9bq0zu.txt cache: ./cache/cord-346345-jc9bq0zu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346345-jc9bq0zu.txt' === file2bib.sh === id: cord-344853-s2p2csrx author: Hendren, Nicholas S. title: Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome date: 2020-04-16 pages: extension: .txt txt: ./txt/cord-344853-s2p2csrx.txt cache: ./cache/cord-344853-s2p2csrx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-344853-s2p2csrx.txt' === file2bib.sh === id: cord-345546-v7t26oos author: Wilenius, Lukas title: Attention-Deficit/Hyperactivity Disorder Patients May Have Undiagnosed Narcolepsy date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-345546-v7t26oos.txt cache: ./cache/cord-345546-v7t26oos.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-345546-v7t26oos.txt' === file2bib.sh === id: cord-346594-tbsxgz43 author: Tang, Sydney C. W. title: Peritoneal dialysis: the ideal bridge from conservative therapy to kidney transplant date: 2020-07-11 pages: extension: .txt txt: ./txt/cord-346594-tbsxgz43.txt cache: ./cache/cord-346594-tbsxgz43.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346594-tbsxgz43.txt' === file2bib.sh === id: cord-347696-rsjwp0b3 author: Roberts, Haydn title: Reply to the Letter to the Editor: Can Sural Fasciocutaneous Flaps Be Effective in Patients Older Than 65? date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-347696-rsjwp0b3.txt cache: ./cache/cord-347696-rsjwp0b3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-347696-rsjwp0b3.txt' === file2bib.sh === id: cord-347293-fp8phk0p author: Kearns, Donovan G. title: Assessing The Risk of Adalimumab Use For Hidradenitis Suppurativa During The COVID-19 Pandemic date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-347293-fp8phk0p.txt cache: ./cache/cord-347293-fp8phk0p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-347293-fp8phk0p.txt' === file2bib.sh === id: cord-346241-w076l97s author: Zhang, Hua title: Dynamic CT assessment of disease change and prognosis of patients with moderate COVID-19 pneumonia date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-346241-w076l97s.txt cache: ./cache/cord-346241-w076l97s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-346241-w076l97s.txt' === file2bib.sh === id: cord-346459-tkt5ldyo author: Jie, Li Shao title: Risk factors for Coronavirus disease 2019 pneumonia after admission outside Wuhan, China date: 2020-11-06 pages: extension: .txt txt: ./txt/cord-346459-tkt5ldyo.txt cache: ./cache/cord-346459-tkt5ldyo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-346459-tkt5ldyo.txt' === file2bib.sh === id: cord-346205-vqgcq3qt author: Sengillo, Jesse D. title: Importance of Patient Advocacy During the COVID-19 Pandemic date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-346205-vqgcq3qt.txt cache: ./cache/cord-346205-vqgcq3qt.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-346205-vqgcq3qt.txt' === file2bib.sh === id: cord-021087-n4epxwn9 author: nan title: ECR – Final Programme: Scientific and Educational Exhibits date: 2004 pages: extension: .txt txt: ./txt/cord-021087-n4epxwn9.txt cache: ./cache/cord-021087-n4epxwn9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-021087-n4epxwn9.txt' === file2bib.sh === id: cord-346276-1dcp05rd author: Bonfá, Eloisa title: How COVID-19 is changing rheumatology clinical practice date: 2020-11-02 pages: extension: .txt txt: ./txt/cord-346276-1dcp05rd.txt cache: ./cache/cord-346276-1dcp05rd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346276-1dcp05rd.txt' === file2bib.sh === id: cord-346664-ilebaqx3 author: Rahul title: Non-COVID Surgical Emergency During the Nationwide Lockdown due to Corona Pandemic: a Critical Appraisal date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-346664-ilebaqx3.txt cache: ./cache/cord-346664-ilebaqx3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-346664-ilebaqx3.txt' === file2bib.sh === id: cord-346987-fbqqf00i author: Guo, Yongwen title: Controls of SARS-CoV-2 transmission in orthodontic practice date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-346987-fbqqf00i.txt cache: ./cache/cord-346987-fbqqf00i.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346987-fbqqf00i.txt' === file2bib.sh === id: cord-346288-9to4sdfq author: Haimovich, A. title: Development and validation of the COVID-19 severity index (CSI): a prognostic tool for early respiratory decompensation date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-346288-9to4sdfq.txt cache: ./cache/cord-346288-9to4sdfq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-346288-9to4sdfq.txt' === file2bib.sh === id: cord-346062-q0trgj12 author: Robert, René title: Ethical dilemmas due to the Covid-19 pandemic date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-346062-q0trgj12.txt cache: ./cache/cord-346062-q0trgj12.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346062-q0trgj12.txt' === file2bib.sh === id: cord-346607-1mewok8l author: Oesterle, Tyler S. title: Substance Use Disorders and Telehealth in the COVID-19 Pandemic Era: A New Outlook date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-346607-1mewok8l.txt cache: ./cache/cord-346607-1mewok8l.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-346607-1mewok8l.txt' === file2bib.sh === id: cord-346721-l6y3n21b author: Vega, Marisa title: From the Trenches: Inpatient Management of COVID-19 in Pregnancy date: 2020-06-15 pages: extension: .txt txt: ./txt/cord-346721-l6y3n21b.txt cache: ./cache/cord-346721-l6y3n21b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-346721-l6y3n21b.txt' === file2bib.sh === id: cord-346015-bzeqs5oh author: Wang, Yeming title: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-346015-bzeqs5oh.txt cache: ./cache/cord-346015-bzeqs5oh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346015-bzeqs5oh.txt' === file2bib.sh === id: cord-347064-ljd121no author: José, Ricardo J. title: Opportunistic bacterial, viral and fungal infections of the lung date: 2016-05-05 pages: extension: .txt txt: ./txt/cord-347064-ljd121no.txt cache: ./cache/cord-347064-ljd121no.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347064-ljd121no.txt' === file2bib.sh === id: cord-346496-crhv0gnt author: Sun, Ying title: Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-346496-crhv0gnt.txt cache: ./cache/cord-346496-crhv0gnt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346496-crhv0gnt.txt' === file2bib.sh === id: cord-347058-kejcwlng author: Akbari, Hamed title: The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-347058-kejcwlng.txt cache: ./cache/cord-347058-kejcwlng.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-347058-kejcwlng.txt' === file2bib.sh === id: cord-347091-wbjpa5st author: Davis, Matthew R. title: That Escalated Quickly: Remdesivir's Place in Therapy for COVID-19 date: 2020-07-10 pages: extension: .txt txt: ./txt/cord-347091-wbjpa5st.txt cache: ./cache/cord-347091-wbjpa5st.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347091-wbjpa5st.txt' === file2bib.sh === id: cord-315598-qwh72inx author: Mendoza, Jose Luis Accini title: ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19 date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-315598-qwh72inx.txt cache: ./cache/cord-315598-qwh72inx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-315598-qwh72inx.txt' === file2bib.sh === id: cord-346616-kr500kgj author: Qian, Song-Zan title: Clinical Characteristics and Outcomes of Severe and Critical Patients With 2019 Novel Coronavirus Disease (COVID-19) in Wenzhou: A Retrospective Study date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-346616-kr500kgj.txt cache: ./cache/cord-346616-kr500kgj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346616-kr500kgj.txt' === file2bib.sh === id: cord-347280-jpwf55l6 author: Skevaki, Chrysanthi title: Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus date: 2020-06-21 pages: extension: .txt txt: ./txt/cord-347280-jpwf55l6.txt cache: ./cache/cord-347280-jpwf55l6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-347280-jpwf55l6.txt' === file2bib.sh === id: cord-348051-o1hxoasp author: Upadhyaya, Gaurav K. title: Challenges and strategies in management of osteoporosis and fragility fracture care during COVID-19 pandemic date: 2020-06-02 pages: extension: .txt txt: ./txt/cord-348051-o1hxoasp.txt cache: ./cache/cord-348051-o1hxoasp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348051-o1hxoasp.txt' === file2bib.sh === id: cord-347255-fl9lur4h author: May, Larissa title: Rapid Multiplex Testing for Upper Respiratory Pathogens in the Emergency Department: A Randomized Controlled Trial date: 2019-11-05 pages: extension: .txt txt: ./txt/cord-347255-fl9lur4h.txt cache: ./cache/cord-347255-fl9lur4h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-347255-fl9lur4h.txt' === file2bib.sh === id: cord-347414-t88654wo author: Peng, Mian title: Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy date: 2020-08-06 pages: extension: .txt txt: ./txt/cord-347414-t88654wo.txt cache: ./cache/cord-347414-t88654wo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-347414-t88654wo.txt' === file2bib.sh === id: cord-348422-werg9ofa author: Shamsah, Mohammed A title: Right atrial thrombus in a patient with COVID-19 pneumonia: a case report date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-348422-werg9ofa.txt cache: ./cache/cord-348422-werg9ofa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348422-werg9ofa.txt' === file2bib.sh === id: cord-347238-yacn6xqk author: Angurala, Mohit title: An Internet of Things Assisted Drone Based Approach to Reduce Rapid Spread of Covid-19 date: 2020-07-02 pages: extension: .txt txt: ./txt/cord-347238-yacn6xqk.txt cache: ./cache/cord-347238-yacn6xqk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347238-yacn6xqk.txt' === file2bib.sh === id: cord-348458-dwj90mbq author: Narula, Nupoor title: Cardiology Practice and Training Post-COVID-19: Achieving “Normalcy” After Disruption date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-348458-dwj90mbq.txt cache: ./cache/cord-348458-dwj90mbq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-348458-dwj90mbq.txt' === file2bib.sh === id: cord-346558-u1e0kzmm author: Cattaruzza, Maria Sofia title: Tobacco smoking and COVID-19 pandemic: old and new issues. A summary of the evidence from the scientific literature date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-346558-u1e0kzmm.txt cache: ./cache/cord-346558-u1e0kzmm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346558-u1e0kzmm.txt' === file2bib.sh === id: cord-348172-q3zcn5pf author: Poli, Daniela title: Managing anticoagulation in the COVID-19 era between lockdown and reopening phases date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-348172-q3zcn5pf.txt cache: ./cache/cord-348172-q3zcn5pf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348172-q3zcn5pf.txt' === file2bib.sh === id: cord-347105-my9nioko author: Foster, Carolyn C. title: Integrated Multimodality Telemedicine to Enhance In-Home Care of Infants During the Interstage Period date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-347105-my9nioko.txt cache: ./cache/cord-347105-my9nioko.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347105-my9nioko.txt' === file2bib.sh === id: cord-348881-w0moe21t author: Creel-Bulos, Christina title: Acute Cor Pulmonale in Critically Ill Patients with Covid-19 date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-348881-w0moe21t.txt cache: ./cache/cord-348881-w0moe21t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-348881-w0moe21t.txt' === file2bib.sh === id: cord-347607-ydbyonbg author: Spagnuolo, Rocco title: COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-347607-ydbyonbg.txt cache: ./cache/cord-347607-ydbyonbg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347607-ydbyonbg.txt' === file2bib.sh === id: cord-348501-8cvtqj7w author: Beyzaee, Amir Mohammad title: Rituximab as the treatment of pemphigus vulgaris in the COVID‐19 pandemic era: A narrative review date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-348501-8cvtqj7w.txt cache: ./cache/cord-348501-8cvtqj7w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348501-8cvtqj7w.txt' === file2bib.sh === id: cord-347375-5ucemm87 author: Sazzad, Hossain M.S. title: Nipah Virus Infection Outbreak with Nosocomial and Corpse-to-Human Transmission, Bangladesh date: 2013-02-17 pages: extension: .txt txt: ./txt/cord-347375-5ucemm87.txt cache: ./cache/cord-347375-5ucemm87.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-347375-5ucemm87.txt' === file2bib.sh === id: cord-346894-iy35298o author: Miranda-Schaeubinger, Monica title: A primer for pediatric radiologists on infection control in an era of COVID-19 date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-346894-iy35298o.txt cache: ./cache/cord-346894-iy35298o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-346894-iy35298o.txt' === file2bib.sh === id: cord-345371-pjbviagq author: Lisi, Lucia title: Approaching Coronavirus Disease 2019: mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2 date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-345371-pjbviagq.txt cache: ./cache/cord-345371-pjbviagq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-345371-pjbviagq.txt' === file2bib.sh === id: cord-347277-8bmcd22v author: Huang, Ying hui title: The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-347277-8bmcd22v.txt cache: ./cache/cord-347277-8bmcd22v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-347277-8bmcd22v.txt' === file2bib.sh === id: cord-348202-6we8e60b author: Drake, Daniel H. title: Echo in Pandemic: Front Line Perspective, Expanding Role of Ultrasound and Ethics of Resource Allocation date: 2020-04-10 pages: extension: .txt txt: ./txt/cord-348202-6we8e60b.txt cache: ./cache/cord-348202-6we8e60b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-348202-6we8e60b.txt' === file2bib.sh === id: cord-347268-vb6z0hzb author: Wicclair, Mark R. title: Is conscientious objection incompatible with a physician’s professional obligations? date: 2008-08-28 pages: extension: .txt txt: ./txt/cord-347268-vb6z0hzb.txt cache: ./cache/cord-347268-vb6z0hzb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-347268-vb6z0hzb.txt' === file2bib.sh === id: cord-347697-uz0i6wfp author: McLean, Ross C. title: A single-centre observational cohort study to evaluate volume and severity of emergency general surgery admissions during the COVID-19 pandemic: is there a “lockdown” effect? date: 2020-09-12 pages: extension: .txt txt: ./txt/cord-347697-uz0i6wfp.txt cache: ./cache/cord-347697-uz0i6wfp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-347697-uz0i6wfp.txt' === file2bib.sh === id: cord-348430-8xk4dt7t author: Bragazzi, Nicola Luigi title: COVID‐19 knowledge prevents biologics discontinuation: Data from an Italian multicenter survey during RED‐ZONE declaration date: 2020-05-28 pages: extension: .txt txt: ./txt/cord-348430-8xk4dt7t.txt cache: ./cache/cord-348430-8xk4dt7t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348430-8xk4dt7t.txt' === file2bib.sh === id: cord-348672-e34103b1 author: Zhang, Jiaqi title: Postoperative Short-term Outcomes Between Sublobar Resection and Lobectomy in Patients with Lung Adenocarcinoma date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-348672-e34103b1.txt cache: ./cache/cord-348672-e34103b1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348672-e34103b1.txt' === file2bib.sh === id: cord-348423-zq86ms8w author: Louvardi, Maya title: Mental health in chronic disease patients during the COVID-19 quarantine in Greece date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-348423-zq86ms8w.txt cache: ./cache/cord-348423-zq86ms8w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348423-zq86ms8w.txt' === file2bib.sh === id: cord-348578-chfb4i15 author: Bulman, Julie C. title: Transitioning the IR Clinic to Telehealth: A Single-Center Experience during the COVID-19 Pandemic date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-348578-chfb4i15.txt cache: ./cache/cord-348578-chfb4i15.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348578-chfb4i15.txt' === file2bib.sh === id: cord-348813-v1sdodz9 author: Kefale, Belayneh title: Prevalence and Risk Factors of Thromboembolism among Patients With Coronavirus Disease-19: A Systematic Review and Meta-Analysis date: 2020-10-19 pages: extension: .txt txt: ./txt/cord-348813-v1sdodz9.txt cache: ./cache/cord-348813-v1sdodz9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348813-v1sdodz9.txt' === file2bib.sh === id: cord-347752-2ejnva4u author: Mrabti, Hind title: Cancer management challenge in a developing country in COVID-19 pandemic: reflection of a group of Moroccan oncologists date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-347752-2ejnva4u.txt cache: ./cache/cord-347752-2ejnva4u.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-347752-2ejnva4u.txt' === file2bib.sh === id: cord-348879-opzkodt7 author: Nune, A. title: Challenges in delivering rheumatology care during COVID-19 pandemic date: 2020-07-25 pages: extension: .txt txt: ./txt/cord-348879-opzkodt7.txt cache: ./cache/cord-348879-opzkodt7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348879-opzkodt7.txt' === file2bib.sh === id: cord-348364-jb0lvhq5 author: Rehman, Tyler title: Spontaneous Pneumothorax in an Elderly Patient With Coronavirus Disease (COVID-19) Pneumonia date: 2020 pages: extension: .txt txt: ./txt/cord-348364-jb0lvhq5.txt cache: ./cache/cord-348364-jb0lvhq5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348364-jb0lvhq5.txt' === file2bib.sh === id: cord-348755-2g5gi1du author: Chow, D. S. title: Development and External Validation of a Prognostic Tool for COVID-19 Critical Disease date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-348755-2g5gi1du.txt cache: ./cache/cord-348755-2g5gi1du.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348755-2g5gi1du.txt' === file2bib.sh === id: cord-346389-gbmnoo84 author: Callender, Lauren A. title: The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19 date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-346389-gbmnoo84.txt cache: ./cache/cord-346389-gbmnoo84.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-346389-gbmnoo84.txt' === file2bib.sh === id: cord-347263-ci6mv72z author: Berekashvili, k. title: Etiologic Subtypes of Ischemic Stroke in SARS-COV-2 Virus patients date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-347263-ci6mv72z.txt cache: ./cache/cord-347263-ci6mv72z.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347263-ci6mv72z.txt' === file2bib.sh === id: cord-345092-1ztfcpsb author: Iwasaki, Masae title: Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-345092-1ztfcpsb.txt cache: ./cache/cord-345092-1ztfcpsb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345092-1ztfcpsb.txt' === file2bib.sh === id: cord-349533-51cex2sl author: Yeoh, Su-Ann title: Are treat-to-target and dose tapering strategies for rheumatoid arthritis possible during the COVID-19 pandemic? date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-349533-51cex2sl.txt cache: ./cache/cord-349533-51cex2sl.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349533-51cex2sl.txt' === file2bib.sh === id: cord-348855-lnltoj1n author: Iannaccone, Giulia title: Weathering the Cytokine Storm in COVID-19: Therapeutic Implications date: 2020-06-29 pages: extension: .txt txt: ./txt/cord-348855-lnltoj1n.txt cache: ./cache/cord-348855-lnltoj1n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348855-lnltoj1n.txt' === file2bib.sh === id: cord-349565-g1emvmdu author: Conti, Clara Benedetta title: Bleeding in COVID-19 severe pneumonia: The other side of abnormal coagulation pattern? date: 2020-05-07 pages: extension: .txt txt: ./txt/cord-349565-g1emvmdu.txt cache: ./cache/cord-349565-g1emvmdu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-349565-g1emvmdu.txt' === file2bib.sh === id: cord-348975-plne3xlz author: Wagner, Tyler title: Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-348975-plne3xlz.txt cache: ./cache/cord-348975-plne3xlz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348975-plne3xlz.txt' === file2bib.sh === id: cord-347289-3yi5tz04 author: Poon, L. . C. title: ISUOG Interim Guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium: information for healthcare professionals – an update date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-347289-3yi5tz04.txt cache: ./cache/cord-347289-3yi5tz04.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-347289-3yi5tz04.txt' === file2bib.sh === id: cord-349263-mmfrqyrc author: Rodríguez, A. title: Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic date: 2020-11-09 pages: extension: .txt txt: ./txt/cord-349263-mmfrqyrc.txt cache: ./cache/cord-349263-mmfrqyrc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-349263-mmfrqyrc.txt' === file2bib.sh === id: cord-350232-zml4o93t author: Peck, Richard W title: A Real‐World Evidence Framework for Optimising Dosing in All Patients with COVID‐19 date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-350232-zml4o93t.txt cache: ./cache/cord-350232-zml4o93t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-350232-zml4o93t.txt' === file2bib.sh === id: cord-349144-cvmebr3f author: Barca, Ida title: Telemedicine in Oral and Maxillo-Facial Surgery: An Effective Alternative in Post COVID-19 Pandemic date: 2020-10-09 pages: extension: .txt txt: ./txt/cord-349144-cvmebr3f.txt cache: ./cache/cord-349144-cvmebr3f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349144-cvmebr3f.txt' === file2bib.sh === id: cord-350052-9431xqu1 author: Kim, Ji Heui title: Detection of respiratory viruses in adult patients with perennial allergic rhinitis date: 2013-09-14 pages: extension: .txt txt: ./txt/cord-350052-9431xqu1.txt cache: ./cache/cord-350052-9431xqu1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-350052-9431xqu1.txt' === file2bib.sh === id: cord-349280-12hc3mhq author: Drake, Justin A. title: Analysis of the Survival Impact of Postoperative Chemotherapy After Preoperative Chemotherapy and Resection for Gastric Cancer date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-349280-12hc3mhq.txt cache: ./cache/cord-349280-12hc3mhq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-349280-12hc3mhq.txt' === file2bib.sh === id: cord-350065-frg7gvf5 author: Parolari, Alessandro title: Safety for all: coronavirus disease 2019 pandemic and cardiac surgery: a roadmap to ‘phase’ 2 date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-350065-frg7gvf5.txt cache: ./cache/cord-350065-frg7gvf5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350065-frg7gvf5.txt' === file2bib.sh === id: cord-349958-126yb5se author: Raskin, Jo title: CANCER IN THE TIME OF COVID: Expert opinion on how to adapt current practice date: 2020-04-16 pages: extension: .txt txt: ./txt/cord-349958-126yb5se.txt cache: ./cache/cord-349958-126yb5se.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349958-126yb5se.txt' === file2bib.sh === id: cord-350325-vu8v9epr author: Malih, Narges title: Unexpected Presentation of COVID-19 in a 38-Year-Old Male Patient: A Case Report date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-350325-vu8v9epr.txt cache: ./cache/cord-350325-vu8v9epr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350325-vu8v9epr.txt' === file2bib.sh === id: cord-349678-79zlgjqi author: Warrior, Krishnan title: Acute Limb Ischemia Due to Arterial Thrombosis Associated With Coronavirus Disease 2019 date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-349678-79zlgjqi.txt cache: ./cache/cord-349678-79zlgjqi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349678-79zlgjqi.txt' === file2bib.sh === id: cord-349031-tbof9yqi author: Chen, Shiu-Jau title: Novel Antiviral Strategies in the Treatment of COVID-19: A Review date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-349031-tbof9yqi.txt cache: ./cache/cord-349031-tbof9yqi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349031-tbof9yqi.txt' === file2bib.sh === id: cord-349566-zx9kt144 author: de Alencar, Julio Cesar Garcia title: Double-blind, randomized, placebo-controlled trial with N-acetylcysteine for treatment of severe acute respiratory syndrome caused by COVID-19 date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-349566-zx9kt144.txt cache: ./cache/cord-349566-zx9kt144.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349566-zx9kt144.txt' === file2bib.sh === id: cord-348570-plds5kbn author: Buneviciene, Inesa title: Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-348570-plds5kbn.txt cache: ./cache/cord-348570-plds5kbn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348570-plds5kbn.txt' === file2bib.sh === id: cord-348535-tvs1snq8 author: Ottaviani, Silvia title: What is the best drug to treat COVID-19? The need for randomized controlled trials date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-348535-tvs1snq8.txt cache: ./cache/cord-348535-tvs1snq8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348535-tvs1snq8.txt' === file2bib.sh === id: cord-351195-2fdqu2l1 author: nan title: How to manage, after containment, patients with chronic conditions at risk? date: 2020-07-12 pages: extension: .txt txt: ./txt/cord-351195-2fdqu2l1.txt cache: ./cache/cord-351195-2fdqu2l1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351195-2fdqu2l1.txt' === file2bib.sh === id: cord-347351-emdj66vj author: Kampf, Günter title: Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2 date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-347351-emdj66vj.txt cache: ./cache/cord-347351-emdj66vj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347351-emdj66vj.txt' === file2bib.sh === id: cord-349838-p6vfzbla author: Algwaiz, Ghada title: Real-world issues and potential solutions in HCT during the COVID-19 pandemic: Perspectives from the WBMT and the CIBMTR's Health Services and International Studies Committee date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-349838-p6vfzbla.txt cache: ./cache/cord-349838-p6vfzbla.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349838-p6vfzbla.txt' === file2bib.sh === id: cord-349396-a6zyioc1 author: Tsurumi, Amy title: Multi-biomarker Prediction Models for Multiple Infection Episodes Following Blunt Trauma date: 2020-10-07 pages: extension: .txt txt: ./txt/cord-349396-a6zyioc1.txt cache: ./cache/cord-349396-a6zyioc1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349396-a6zyioc1.txt' === file2bib.sh === id: cord-349439-3z0b77r5 author: Mandal, Amitabha title: A Systematic Review on Tracheostomy in COVID-19 Patients: Current Guidelines and Safety Measures date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-349439-3z0b77r5.txt cache: ./cache/cord-349439-3z0b77r5.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-349439-3z0b77r5.txt' === file2bib.sh === id: cord-349740-xed4aybr author: Wang, Yulong title: Recommendations of protective measures for orthopedic surgeons during COVID-19 pandemic date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-349740-xed4aybr.txt cache: ./cache/cord-349740-xed4aybr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349740-xed4aybr.txt' === file2bib.sh === id: cord-350529-yqtu059x author: Evans, Samantha title: Implementation of a clinical pathway for the surgical treatment of colorectal cancer during the COVID‐19 pandemic date: 2020-07-12 pages: extension: .txt txt: ./txt/cord-350529-yqtu059x.txt cache: ./cache/cord-350529-yqtu059x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350529-yqtu059x.txt' === file2bib.sh === id: cord-349360-dv4lxx52 author: Cozza, Valerio title: I-ACTSS-COVID-19—the Italian acute care and trauma surgery survey for COVID-19 pandemic outbreak date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-349360-dv4lxx52.txt cache: ./cache/cord-349360-dv4lxx52.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349360-dv4lxx52.txt' === file2bib.sh === id: cord-350131-rsrlri8m author: Amer, Mohamed A. title: Early recovery patterns of olfactory disorders in COVID-19 patients; a clinical cohort study date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-350131-rsrlri8m.txt cache: ./cache/cord-350131-rsrlri8m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350131-rsrlri8m.txt' === file2bib.sh === id: cord-349500-603v8lfb author: Neurath, Markus F title: Covid-19 and immunomodulation in IBD date: 2020-04-16 pages: extension: .txt txt: ./txt/cord-349500-603v8lfb.txt cache: ./cache/cord-349500-603v8lfb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-349500-603v8lfb.txt' === file2bib.sh === id: cord-350338-lcsa06gm author: Wang, Kun title: Clinical and laboratory predictors of in-hospital mortality in patients with COVID-19: a cohort study in Wuhan, China date: 2020-05-03 pages: extension: .txt txt: ./txt/cord-350338-lcsa06gm.txt cache: ./cache/cord-350338-lcsa06gm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-350338-lcsa06gm.txt' === file2bib.sh === id: cord-350166-loxe11d6 author: Garmendia, Onintza title: Low-cost, easy-to-build non-invasive pressure support ventilator for under-resourced regions: open source hardware description, performance and feasibility testing date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-350166-loxe11d6.txt cache: ./cache/cord-350166-loxe11d6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350166-loxe11d6.txt' === file2bib.sh === id: cord-350594-0zxq4lxc author: Patel, Ishan title: Life-Threatening Psoas Hematoma due to Retroperitoneal Hemorrhage in a COVID-19 Patient on Enoxaparin Treated With Arterial Embolization: A Case Report date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-350594-0zxq4lxc.txt cache: ./cache/cord-350594-0zxq4lxc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350594-0zxq4lxc.txt' === file2bib.sh === id: cord-350437-dq1il88y author: Reale, Maria Lucia title: SARS-CoV-2 Infection in Cancer Patients: A Picture of an Italian Onco-Covid Unit date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-350437-dq1il88y.txt cache: ./cache/cord-350437-dq1il88y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-350437-dq1il88y.txt' === file2bib.sh === id: cord-350200-1w5u3w8i author: Hendren, Elizabeth M. title: An Interprofessional Approach in Caring for a Patient on Maintenance Hemodialysis with COVID-19 in Toronto, Canada: An Educational Case Report date: 2020-09-08 pages: extension: .txt txt: ./txt/cord-350200-1w5u3w8i.txt cache: ./cache/cord-350200-1w5u3w8i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350200-1w5u3w8i.txt' === file2bib.sh === id: cord-350990-tywbe4o2 author: Checchi, Vittorio title: COVID‐19 dentistry‐related aspects: a literature overview date: 2020-07-05 pages: extension: .txt txt: ./txt/cord-350990-tywbe4o2.txt cache: ./cache/cord-350990-tywbe4o2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-350990-tywbe4o2.txt' === file2bib.sh === id: cord-349949-jp0hvcg6 author: Freer, Phoebe E. title: The impact of the COVID-19 pandemic on Breast Imaging date: 2020-09-22 pages: extension: .txt txt: ./txt/cord-349949-jp0hvcg6.txt cache: ./cache/cord-349949-jp0hvcg6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-349949-jp0hvcg6.txt' === file2bib.sh === id: cord-351223-nnuoadh6 author: Pettit, Natasha N. title: Obesity is Associated with Increased Risk for Mortality Among Hospitalized Patients with COVID‐19 date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-351223-nnuoadh6.txt cache: ./cache/cord-351223-nnuoadh6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351223-nnuoadh6.txt' === file2bib.sh === id: cord-350679-69lv4wbz author: Shinde, Rajesh S. title: To Do or Not to Do?—A Review of Cancer Surgery Triage Guidelines in COVID-19 Pandemic date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-350679-69lv4wbz.txt cache: ./cache/cord-350679-69lv4wbz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-350679-69lv4wbz.txt' === file2bib.sh === id: cord-347905-w0fnc43a author: Schwartz, Joseph S. title: Diseases of the nasal cavity date: 2019-10-08 pages: extension: .txt txt: ./txt/cord-347905-w0fnc43a.txt cache: ./cache/cord-347905-w0fnc43a.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347905-w0fnc43a.txt' === file2bib.sh === id: cord-351457-fzj3ciif author: Vezzoli, Pamela title: Cutaneous lupus erythematosus patients in a high‐epidemic COVID‐19 area, Bergamo, Italy date: 2020-06-07 pages: extension: .txt txt: ./txt/cord-351457-fzj3ciif.txt cache: ./cache/cord-351457-fzj3ciif.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351457-fzj3ciif.txt' === file2bib.sh === id: cord-351446-j4ambec5 author: Sinonquel, P. title: COVID‐19 and gastrointestinal endoscopy: what should be taken into account? date: 2020-04-26 pages: extension: .txt txt: ./txt/cord-351446-j4ambec5.txt cache: ./cache/cord-351446-j4ambec5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351446-j4ambec5.txt' === file2bib.sh === id: cord-351224-jeedo5mc author: GeurtsvanKessel, Corine H. title: An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment date: 2020-07-06 pages: extension: .txt txt: ./txt/cord-351224-jeedo5mc.txt cache: ./cache/cord-351224-jeedo5mc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-351224-jeedo5mc.txt' === file2bib.sh === id: cord-350737-nrtrhq1f author: Chen, Xinchun title: Serology of Severe Acute Respiratory Syndrome: Implications for Surveillance and Outcome date: 2004-04-01 pages: extension: .txt txt: ./txt/cord-350737-nrtrhq1f.txt cache: ./cache/cord-350737-nrtrhq1f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-350737-nrtrhq1f.txt' === file2bib.sh === id: cord-349210-8t4a5qqo author: Ji, Ping title: Immunomodulatory Therapeutic Proteins in COVID‐19: Current Clinical Development and Clinical Pharmacology Considerations date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-349210-8t4a5qqo.txt cache: ./cache/cord-349210-8t4a5qqo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-349210-8t4a5qqo.txt' === file2bib.sh === id: cord-350401-suefuurq author: Lima-Setta, Fernanda title: Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study()()() date: 2020-11-09 pages: extension: .txt txt: ./txt/cord-350401-suefuurq.txt cache: ./cache/cord-350401-suefuurq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-350401-suefuurq.txt' === file2bib.sh === id: cord-350179-ltk5hfc4 author: Paganini, Matteo title: Translating COVID-19 Pandemic Surge Theory to Practice in the Emergency Department: How to Expand Structure date: 2020-03-27 pages: extension: .txt txt: ./txt/cord-350179-ltk5hfc4.txt cache: ./cache/cord-350179-ltk5hfc4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-350179-ltk5hfc4.txt' === file2bib.sh === id: cord-351528-23lbs8al author: Zacharia, Brad E title: Letter: Surgical Management of Brain Tumor Patients in the COVID-19 Era date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-351528-23lbs8al.txt cache: ./cache/cord-351528-23lbs8al.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-351528-23lbs8al.txt' === file2bib.sh === id: cord-349775-zwslhjju author: Brittain-Long, Robin title: Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial date: 2011-04-26 pages: extension: .txt txt: ./txt/cord-349775-zwslhjju.txt cache: ./cache/cord-349775-zwslhjju.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-349775-zwslhjju.txt' === file2bib.sh === id: cord-350589-h6hotlqk author: Cieszanowski, Andrzej title: Management of patients with COVID-19 in radiology departments, and indications regarding imaging studies – recommendations of the Polish Medical Society of Radiology date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-350589-h6hotlqk.txt cache: ./cache/cord-350589-h6hotlqk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-350589-h6hotlqk.txt' === file2bib.sh === id: cord-350639-iguadmw1 author: Padlina, G title: Secondary Cerebrovascular Prevention in Light of the COVID-19 Pandemic date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-350639-iguadmw1.txt cache: ./cache/cord-350639-iguadmw1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-350639-iguadmw1.txt' === file2bib.sh === id: cord-351020-wde3ki0k author: Allione, Attilio title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-351020-wde3ki0k.txt cache: ./cache/cord-351020-wde3ki0k.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351020-wde3ki0k.txt' === file2bib.sh === id: cord-348130-t9tysvr8 author: Cho, Sung-Yeon title: Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea date: 2018-02-27 pages: extension: .txt txt: ./txt/cord-348130-t9tysvr8.txt cache: ./cache/cord-348130-t9tysvr8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-348130-t9tysvr8.txt' === file2bib.sh === id: cord-350578-wyz5jyjh author: Bai, Li title: Chinese experts’ consensus on the Internet of Things-aided diagnosis and treatment of coronavirus disease 2019 (COVID-19) date: 2020-12-31 pages: extension: .txt txt: ./txt/cord-350578-wyz5jyjh.txt cache: ./cache/cord-350578-wyz5jyjh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-350578-wyz5jyjh.txt' === file2bib.sh === id: cord-351184-kcc3p3ow author: Dotters-Katz, Sarah K. title: Considerations for Obstetric Care during the COVID-19 Pandemic date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-351184-kcc3p3ow.txt cache: ./cache/cord-351184-kcc3p3ow.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351184-kcc3p3ow.txt' === file2bib.sh === id: cord-351155-5bvo66yb author: Kushner, Tatyana title: Chronic Liver Disease and COVID‐19: Alcohol Use Disorder/Alcohol‐Associated Liver Disease, Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Autoimmune Liver Disease, and Compensated Cirrhosis date: 2020-05-21 pages: extension: .txt txt: ./txt/cord-351155-5bvo66yb.txt cache: ./cache/cord-351155-5bvo66yb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351155-5bvo66yb.txt' === file2bib.sh === id: cord-351129-lzzyn570 author: Lee, Jae-Hyun title: Management of Allergic Patients During the COVID-19 Pandemic in Asia date: 2020-06-15 pages: extension: .txt txt: ./txt/cord-351129-lzzyn570.txt cache: ./cache/cord-351129-lzzyn570.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351129-lzzyn570.txt' === file2bib.sh === id: cord-351531-wo1ggmmn author: Giustiniano, Enrico title: Trans-thoracic Echocardiography in Prone Positioning COVID-19 Patients: a Small Case Series date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-351531-wo1ggmmn.txt cache: ./cache/cord-351531-wo1ggmmn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351531-wo1ggmmn.txt' === file2bib.sh === id: cord-349076-x3rjasg0 author: Jarczak, Dominik title: Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-349076-x3rjasg0.txt cache: ./cache/cord-349076-x3rjasg0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349076-x3rjasg0.txt' === file2bib.sh === id: cord-349408-2ser9zjc author: Iannuzzi, Nicholas P. title: An Orthopaedic Department’s Response to the COVID-19 Health-Care Crisis: Indirect and Direct Actions with Thoughts for the Future date: 2020-05-05 pages: extension: .txt txt: ./txt/cord-349408-2ser9zjc.txt cache: ./cache/cord-349408-2ser9zjc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349408-2ser9zjc.txt' === file2bib.sh === id: cord-351046-yq7287k9 author: Schubert, Gena title: How Much Drool Is Too Much?() date: 2019-12-13 pages: extension: .txt txt: ./txt/cord-351046-yq7287k9.txt cache: ./cache/cord-351046-yq7287k9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351046-yq7287k9.txt' === file2bib.sh === id: cord-351340-7y19ystp author: Rao, Gundu H. R. title: Coronavirus Disease and Acute Vascular Events date: 2020-07-31 pages: extension: .txt txt: ./txt/cord-351340-7y19ystp.txt cache: ./cache/cord-351340-7y19ystp.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351340-7y19ystp.txt' === file2bib.sh === id: cord-351825-fdog73g2 author: Tsai, Cheng-Yu title: A Novel Non-contact Self-Injection-Locked Radar for Vital Sign Sensing and Body Movement Monitoring in COVID-19 Isolation Ward date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-351825-fdog73g2.txt cache: ./cache/cord-351825-fdog73g2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351825-fdog73g2.txt' === file2bib.sh === id: cord-349329-f0pbd968 author: Bosteels, Cedric title: Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-349329-f0pbd968.txt cache: ./cache/cord-349329-f0pbd968.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-349329-f0pbd968.txt' === file2bib.sh === id: cord-351762-n95ar9ci author: Wang, Brian Xiangzhi title: Susceptibility and prognosis of COVID-19 patients with cardiovascular disease date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-351762-n95ar9ci.txt cache: ./cache/cord-351762-n95ar9ci.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351762-n95ar9ci.txt' === file2bib.sh === id: cord-349561-4mkiwg9k author: Porta, Alessandra Della title: Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians date: 2020-07-19 pages: extension: .txt txt: ./txt/cord-349561-4mkiwg9k.txt cache: ./cache/cord-349561-4mkiwg9k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-349561-4mkiwg9k.txt' === file2bib.sh === id: cord-350408-rqlkwoya author: Rajewsky, Nikolaus title: LifeTime and improving European healthcare through cell-based interceptive medicine date: 2020-09-07 pages: extension: .txt txt: ./txt/cord-350408-rqlkwoya.txt cache: ./cache/cord-350408-rqlkwoya.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-350408-rqlkwoya.txt' === file2bib.sh === id: cord-352401-tmt1pmw9 author: Curatola, Antonietta title: Use of Handheld Transceiver for Hospital Healthcare Workers-Caregiver Communication During the Coronavirus disease 2019 (COVID-19) Outbreak in Pediatric Emergency Department date: 2020-04-13 pages: extension: .txt txt: ./txt/cord-352401-tmt1pmw9.txt cache: ./cache/cord-352401-tmt1pmw9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-352401-tmt1pmw9.txt' === file2bib.sh === id: cord-347121-5drl3xas author: Farah, I. title: A global omics data sharing and analytics marketplace: Case study of a rapid data COVID-19 pandemic response platform. date: 2020-09-29 pages: extension: .txt txt: ./txt/cord-347121-5drl3xas.txt cache: ./cache/cord-347121-5drl3xas.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-347121-5drl3xas.txt' === file2bib.sh === id: cord-351604-x4rsdwqz author: González-Gay, Miguel A. title: BioLogic THERAPY IN COVID-19 date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-351604-x4rsdwqz.txt cache: ./cache/cord-351604-x4rsdwqz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351604-x4rsdwqz.txt' === file2bib.sh === id: cord-351735-x1lng449 author: Flikweert, Antine W. title: Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-351735-x1lng449.txt cache: ./cache/cord-351735-x1lng449.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351735-x1lng449.txt' === file2bib.sh === id: cord-350959-bsbz3a1l author: Dovey, Zachary title: Impact of COVID-19 on Prostate Cancer Management: Guidelines for Urologists date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-350959-bsbz3a1l.txt cache: ./cache/cord-350959-bsbz3a1l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350959-bsbz3a1l.txt' === file2bib.sh === id: cord-352234-utjne1ef author: Mendlovic, Joseph title: Internal medicine patients admitted without COVID‐19 during the outbreak date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-352234-utjne1ef.txt cache: ./cache/cord-352234-utjne1ef.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-352234-utjne1ef.txt' === file2bib.sh === id: cord-352193-izzqdg3v author: Allen, M. title: Organising outpatient dialysis services during the COVID-19 pandemic. A simulation and mathematical modelling study. date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-352193-izzqdg3v.txt cache: ./cache/cord-352193-izzqdg3v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352193-izzqdg3v.txt' === file2bib.sh === id: cord-351625-1we9wi1g author: Han, Huan title: Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients date: 2020-10-07 pages: extension: .txt txt: ./txt/cord-351625-1we9wi1g.txt cache: ./cache/cord-351625-1we9wi1g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-351625-1we9wi1g.txt' === file2bib.sh === id: cord-351819-ovpz36e7 author: Beyrouti, Rahma title: Characteristics of ischaemic stroke associated with COVID-19 date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-351819-ovpz36e7.txt cache: ./cache/cord-351819-ovpz36e7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351819-ovpz36e7.txt' === file2bib.sh === id: cord-351597-bdazrbsz author: Thalappillil, Richard title: POCUS to guide fluid-therapy in COVID-19 date: 2020-05-06 pages: extension: .txt txt: ./txt/cord-351597-bdazrbsz.txt cache: ./cache/cord-351597-bdazrbsz.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351597-bdazrbsz.txt' === file2bib.sh === id: cord-351776-otx5qwyu author: Ibáñez-Samaniego, Luis title: Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19 date: 2020-06-21 pages: extension: .txt txt: ./txt/cord-351776-otx5qwyu.txt cache: ./cache/cord-351776-otx5qwyu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351776-otx5qwyu.txt' === file2bib.sh === id: cord-352302-are8vvhh author: Hartman, W. title: Hospitalized COVID-19 patients treated with Convalescent Plasma in a mid-size city in the midwest date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-352302-are8vvhh.txt cache: ./cache/cord-352302-are8vvhh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-352302-are8vvhh.txt' === file2bib.sh === id: cord-350904-wyg8ikph author: Gubernatorova, E.O. title: IL-6: relevance for immunopathology of SARS-CoV-2 date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-350904-wyg8ikph.txt cache: ./cache/cord-350904-wyg8ikph.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-350904-wyg8ikph.txt' === file2bib.sh === id: cord-351896-j6h02ab5 author: Ghannam, Malik title: Neurological involvement of coronavirus disease 2019: a systematic review date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-351896-j6h02ab5.txt cache: ./cache/cord-351896-j6h02ab5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351896-j6h02ab5.txt' === file2bib.sh === id: cord-352065-960xqft4 author: Rello, Jordi title: Update in COVID-19 in the Intensive Care Unit from the 2020 HELLENIC Athens International Symposium date: 2020-10-22 pages: extension: .txt txt: ./txt/cord-352065-960xqft4.txt cache: ./cache/cord-352065-960xqft4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352065-960xqft4.txt' === file2bib.sh === id: cord-346539-kxnrf5g5 author: Riggioni, Carmen title: A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2 date: 2020-06-14 pages: extension: .txt txt: ./txt/cord-346539-kxnrf5g5.txt cache: ./cache/cord-346539-kxnrf5g5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-346539-kxnrf5g5.txt' === file2bib.sh === id: cord-352846-p7hhv297 author: Bryson, Ethan O. title: A strategy for management of ECT patients during the COVID-19 pandemic date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-352846-p7hhv297.txt cache: ./cache/cord-352846-p7hhv297.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352846-p7hhv297.txt' === file2bib.sh === id: cord-350718-jzliir37 author: Madrazo-González, Z. title: Anemia and transfusion therapy: an update date: 2011-12-31 pages: extension: .txt txt: ./txt/cord-350718-jzliir37.txt cache: ./cache/cord-350718-jzliir37.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350718-jzliir37.txt' === file2bib.sh === id: cord-352215-dhkvh45t author: Ramachandran, Preethi title: Increased serum aminotransferase activity and clinical outcomes in Coronavirus disease 2019 date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-352215-dhkvh45t.txt cache: ./cache/cord-352215-dhkvh45t.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352215-dhkvh45t.txt' === file2bib.sh === id: cord-352914-jccxzit1 author: Sanz Herrero, Francisco title: Methylprednisolone added to tocilizumab reduces mortality in SARS‐CoV‐2 pneumonia: An observational study date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-352914-jccxzit1.txt cache: ./cache/cord-352914-jccxzit1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-352914-jccxzit1.txt' === file2bib.sh === id: cord-352304-tt2q5mgs author: Sun, Dan title: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study date: 2020-03-19 pages: extension: .txt txt: ./txt/cord-352304-tt2q5mgs.txt cache: ./cache/cord-352304-tt2q5mgs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-352304-tt2q5mgs.txt' === file2bib.sh === id: cord-351722-3mw1te94 author: Recalde, M. title: Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-351722-3mw1te94.txt cache: ./cache/cord-351722-3mw1te94.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351722-3mw1te94.txt' === file2bib.sh === id: cord-351823-ldbscq4s author: Leung, Marco Shiu Tsun title: COVID‐19 and Oncology: Service transformation during pandemic date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-351823-ldbscq4s.txt cache: ./cache/cord-351823-ldbscq4s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-351823-ldbscq4s.txt' === file2bib.sh === id: cord-352828-4ecik6xw author: Lagziel, Tomer title: Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) date: 2020-05-19 pages: extension: .txt txt: ./txt/cord-352828-4ecik6xw.txt cache: ./cache/cord-352828-4ecik6xw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-352828-4ecik6xw.txt' === file2bib.sh === id: cord-352177-05sku8a8 author: Pahus, Laurie title: Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials? date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-352177-05sku8a8.txt cache: ./cache/cord-352177-05sku8a8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-352177-05sku8a8.txt' === file2bib.sh === id: cord-352544-7b6btzrx author: Liu, Zhelong title: The association of diabetes and the prognosis of COVID-19 patients: a retrospective study date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-352544-7b6btzrx.txt cache: ./cache/cord-352544-7b6btzrx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352544-7b6btzrx.txt' === file2bib.sh === id: cord-352159-qx16i7s1 author: Pettit, Natasha N. title: Late Onset Infectious Complications and Safety of Tocilizumab in the Management of COVID‐19 date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-352159-qx16i7s1.txt cache: ./cache/cord-352159-qx16i7s1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352159-qx16i7s1.txt' === file2bib.sh === id: cord-353281-leb7c7b0 author: Spiezia, Luca title: COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure date: 2020-04-21 pages: extension: .txt txt: ./txt/cord-353281-leb7c7b0.txt cache: ./cache/cord-353281-leb7c7b0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353281-leb7c7b0.txt' === file2bib.sh === id: cord-351431-xcqz9d3t author: Wang, Jun title: Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19 date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-351431-xcqz9d3t.txt cache: ./cache/cord-351431-xcqz9d3t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-351431-xcqz9d3t.txt' === file2bib.sh === id: cord-352823-1os3kwp1 author: Zeng, Hui title: The strategies of perioperative management in orthopedic department during the pandemic of COVID-19 date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-352823-1os3kwp1.txt cache: ./cache/cord-352823-1os3kwp1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352823-1os3kwp1.txt' === file2bib.sh === id: cord-352577-h3652seb author: Kopić, Jasminka title: Expanding the Use of Noninvasive Ventilation During an Epidemic date: 2014-08-27 pages: extension: .txt txt: ./txt/cord-352577-h3652seb.txt cache: ./cache/cord-352577-h3652seb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352577-h3652seb.txt' === file2bib.sh === id: cord-353180-hbwrzm6s author: Umoren, Rachel A. title: In-Hospital Telehealth Supports Care for Neonatal Patients in Strict Isolation date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-353180-hbwrzm6s.txt cache: ./cache/cord-353180-hbwrzm6s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353180-hbwrzm6s.txt' === file2bib.sh === id: cord-354127-sb8tovy2 author: de Abreu, Andrea Pio title: Recommendations from the Brazilian Society of Nephrology regarding the use of cloth face coverings, by chronic kidney patients in dialysis, during the new coronavirus pandemic (Covid-19) date: 2020-08-26 pages: extension: .txt txt: ./txt/cord-354127-sb8tovy2.txt cache: ./cache/cord-354127-sb8tovy2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354127-sb8tovy2.txt' === file2bib.sh === id: cord-352901-ia34l2ml author: Natalello, Gerlando title: Nailfold capillaroscopy findings in patients with coronavirus disease 19: Broadening the spectrum of covid-19 microvascular involvement() date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-352901-ia34l2ml.txt cache: ./cache/cord-352901-ia34l2ml.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352901-ia34l2ml.txt' === file2bib.sh === id: cord-353375-92pu0pp0 author: Hung, Jennifer C. H. title: Implications of COVID-19 for uveitis patients: perspectives from Hong Kong date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-353375-92pu0pp0.txt cache: ./cache/cord-353375-92pu0pp0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-353375-92pu0pp0.txt' === file2bib.sh === id: cord-354223-0ckpz0bx author: Yu, Pengming title: Early Rehabilitation for Critically Ill Patients With COVID-19: More Benefits Than Risks date: 2020-04-13 pages: extension: .txt txt: ./txt/cord-354223-0ckpz0bx.txt cache: ./cache/cord-354223-0ckpz0bx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354223-0ckpz0bx.txt' === file2bib.sh === id: cord-352678-8f2ygul2 author: Prasad, Ashish title: Single Virus Targeting Multiple Organs: What We Know and Where We Are Heading? date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-352678-8f2ygul2.txt cache: ./cache/cord-352678-8f2ygul2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352678-8f2ygul2.txt' === file2bib.sh === id: cord-352937-htmp0avc author: Chow, Velda Ling Yu title: Recommendations for surgical management of recurrent nasopharyngeal carcinoma during COVID‐19 pandemic date: 2020-06-13 pages: extension: .txt txt: ./txt/cord-352937-htmp0avc.txt cache: ./cache/cord-352937-htmp0avc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-352937-htmp0avc.txt' === file2bib.sh === id: cord-352889-fl61z3w3 author: Downs, John B. title: Proposal for Coronavirus Disease 2019 Management date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-352889-fl61z3w3.txt cache: ./cache/cord-352889-fl61z3w3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352889-fl61z3w3.txt' === file2bib.sh === id: cord-353956-gjv5cg3k author: Bali, Rishi Kumar title: Maxillofacial surgery and COVID-19, The Pandemic !! date: 2020-04-11 pages: extension: .txt txt: ./txt/cord-353956-gjv5cg3k.txt cache: ./cache/cord-353956-gjv5cg3k.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353956-gjv5cg3k.txt' === file2bib.sh === id: cord-353648-rl9dts7l author: Kim, Hyun Joo title: Guidelines for the control and prevention of coronavirus disease (COVID-19) transmission in surgical and anesthetic settings date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-353648-rl9dts7l.txt cache: ./cache/cord-353648-rl9dts7l.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-353648-rl9dts7l.txt' === file2bib.sh === id: cord-353228-fxrf5wsp author: Xiao, Yaru title: Clinical characteristics of diarrhea in 90 cases with COVID-19: a descriptive study date: 2020-08-08 pages: extension: .txt txt: ./txt/cord-353228-fxrf5wsp.txt cache: ./cache/cord-353228-fxrf5wsp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353228-fxrf5wsp.txt' === file2bib.sh === id: cord-352399-2xfzpw9m author: Hearn, Jason title: Lived Experiences and Technological Literacy of Heart Failure Patients and Clinicians at a Cardiac Care Centre in Uganda date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-352399-2xfzpw9m.txt cache: ./cache/cord-352399-2xfzpw9m.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-352399-2xfzpw9m.txt' === file2bib.sh === id: cord-352579-ndcbmgfj author: Takahashi, Takuto title: Pharmacogenomics of COVID-19 therapies date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-352579-ndcbmgfj.txt cache: ./cache/cord-352579-ndcbmgfj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352579-ndcbmgfj.txt' === file2bib.sh === id: cord-353059-39msyuxb author: Chroboczek, T. title: Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis. date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-353059-39msyuxb.txt cache: ./cache/cord-353059-39msyuxb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-353059-39msyuxb.txt' === file2bib.sh === id: cord-351555-hsgsuor2 author: Constantinou, Constantina title: Developing a holistic contingency plan: Challenges and dilemmas for cancer patients during the COVID‐19 date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-351555-hsgsuor2.txt cache: ./cache/cord-351555-hsgsuor2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-351555-hsgsuor2.txt' === file2bib.sh === id: cord-353256-7nfklun9 author: Eroglu‐Ertugrul, Nesibe Gevher title: The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children date: 2019-11-22 pages: extension: .txt txt: ./txt/cord-353256-7nfklun9.txt cache: ./cache/cord-353256-7nfklun9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-353256-7nfklun9.txt' === file2bib.sh === id: cord-352969-rpt7xja6 author: Kataria, Ashish title: COVID-19 in Kidney Transplantation: Epidemiology, Management Considerations, and the Impact on Kidney Transplant Practice date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-352969-rpt7xja6.txt cache: ./cache/cord-352969-rpt7xja6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-352969-rpt7xja6.txt' === file2bib.sh === id: cord-354160-sca9bgeq author: Al-Tawfiq, Jaffar A. title: Changes in Healthcare managing COVID and non-COVID-19 patients during the pandemic: Striking the balance date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-354160-sca9bgeq.txt cache: ./cache/cord-354160-sca9bgeq.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354160-sca9bgeq.txt' === file2bib.sh === id: cord-352227-827987jf author: Chernevskaya, Ekaterina title: Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-352227-827987jf.txt cache: ./cache/cord-352227-827987jf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352227-827987jf.txt' === file2bib.sh === id: cord-353697-ocxextfj author: Santana, Monique Freire title: Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-353697-ocxextfj.txt cache: ./cache/cord-353697-ocxextfj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353697-ocxextfj.txt' === file2bib.sh === id: cord-353004-ocnp758o author: Prakash, Lakshmanan title: COVID-19 in the operating room: a review of evolving safety protocols date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-353004-ocnp758o.txt cache: ./cache/cord-353004-ocnp758o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353004-ocnp758o.txt' === file2bib.sh === id: cord-353013-7cx0gnum author: DENG, Pengbo title: Bronchial Fistula: Rare Complication of Treatment with Anlotinib date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-353013-7cx0gnum.txt cache: ./cache/cord-353013-7cx0gnum.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353013-7cx0gnum.txt' === file2bib.sh === id: cord-353987-hj94a04i author: Lehmann, L. H. title: Establishing an oncocardiology service date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-353987-hj94a04i.txt cache: ./cache/cord-353987-hj94a04i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-353987-hj94a04i.txt' === file2bib.sh === id: cord-353786-284qn075 author: Chen, Zhi-Min title: Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus date: 2020-02-05 pages: extension: .txt txt: ./txt/cord-353786-284qn075.txt cache: ./cache/cord-353786-284qn075.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353786-284qn075.txt' === file2bib.sh === id: cord-352905-ge3u32hm author: Galimberti, Sara title: Tyrosine Kinase Inhibitors Play an Antiviral Action in Patients Affected by Chronic Myeloid Leukemia: A Possible Model Supporting Their Use in the Fight Against SARS-CoV-2 date: 2020-09-02 pages: extension: .txt txt: ./txt/cord-352905-ge3u32hm.txt cache: ./cache/cord-352905-ge3u32hm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352905-ge3u32hm.txt' === file2bib.sh === id: cord-353293-vjdwh19x author: nan title: Post-COVID-19 global health strategies: the need for an interdisciplinary approach date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-353293-vjdwh19x.txt cache: ./cache/cord-353293-vjdwh19x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-353293-vjdwh19x.txt' === file2bib.sh === id: cord-353200-5csewb1k author: Jehi, Lara title: Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19 date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-353200-5csewb1k.txt cache: ./cache/cord-353200-5csewb1k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-353200-5csewb1k.txt' === file2bib.sh === id: cord-354373-lldfoptb author: Chi, Jeffrey title: COVID-19 Clinical Research date: 2020-05-05 pages: extension: .txt txt: ./txt/cord-354373-lldfoptb.txt cache: ./cache/cord-354373-lldfoptb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-354373-lldfoptb.txt' === file2bib.sh === id: cord-352557-l7sahv5t author: Takla, Michael title: Chloroquine, hydroxychloroquine, and COVID-19: systematic review and narrative synthesis of efficacy and safety date: 2020-11-13 pages: extension: .txt txt: ./txt/cord-352557-l7sahv5t.txt cache: ./cache/cord-352557-l7sahv5t.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-352557-l7sahv5t.txt' === file2bib.sh === id: cord-353698-gj8sx3zy author: Bibiano-Guillen, C. title: Adapted Diving Mask (ADM) device as respiratory support with oxygen output during COVID-19 pandemic date: 2020-10-28 pages: extension: .txt txt: ./txt/cord-353698-gj8sx3zy.txt cache: ./cache/cord-353698-gj8sx3zy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-353698-gj8sx3zy.txt' === file2bib.sh === id: cord-353824-0oyvia6d author: Farooque, Umar title: Coronavirus Disease 2019-Related Acute Ischemic Stroke: A Case Report date: 2020-09-08 pages: extension: .txt txt: ./txt/cord-353824-0oyvia6d.txt cache: ./cache/cord-353824-0oyvia6d.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353824-0oyvia6d.txt' === file2bib.sh === id: cord-353599-cw29edwr author: Kelleni, Mina T. title: Early use of Non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-353599-cw29edwr.txt cache: ./cache/cord-353599-cw29edwr.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353599-cw29edwr.txt' === file2bib.sh === id: cord-353340-l0icku0i author: Olaoye, Omotayo title: Improving Access to Antimicrobial Prescribing Guidelines in 4 African Countries: Development and Pilot Implementation of an App and Cross-Sectional Assessment of Attitudes and Behaviour Survey of Healthcare Workers and Patients date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-353340-l0icku0i.txt cache: ./cache/cord-353340-l0icku0i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353340-l0icku0i.txt' === file2bib.sh === id: cord-353401-y1mxnth7 author: Williams, Roger D. title: Moral Injury in Times of COVID-19 date: 2020-05-02 pages: extension: .txt txt: ./txt/cord-353401-y1mxnth7.txt cache: ./cache/cord-353401-y1mxnth7.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-353401-y1mxnth7.txt' === file2bib.sh === id: cord-354749-zkgb16ae author: Chen, Gang title: Core principles for infection prevention in hemodialysis centers during the COVID-19 pandemic date: 2020-04-06 pages: extension: .txt txt: ./txt/cord-354749-zkgb16ae.txt cache: ./cache/cord-354749-zkgb16ae.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354749-zkgb16ae.txt' === file2bib.sh === id: cord-354204-23xkug85 author: Smargiassi, Andrea title: Lung ultrasonography for early management of patients with respiratory symptoms during COVID-19 pandemic date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-354204-23xkug85.txt cache: ./cache/cord-354204-23xkug85.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-354204-23xkug85.txt' === file2bib.sh === id: cord-355003-1o2midnh author: Wang, Min title: Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-355003-1o2midnh.txt cache: ./cache/cord-355003-1o2midnh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355003-1o2midnh.txt' === file2bib.sh === id: cord-354103-4dldgqzf author: Grubic, Andrew D title: COVID-19 outbreak and surgical practice: The rationale for suspending non-urgent surgeries and role of testing modalities date: 2020-06-27 pages: extension: .txt txt: ./txt/cord-354103-4dldgqzf.txt cache: ./cache/cord-354103-4dldgqzf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354103-4dldgqzf.txt' === file2bib.sh === id: cord-354597-xubsodnk author: Carvalho, Alexandre title: SARS-CoV-2 Gastrointestinal Infection Causing Hemorrhagic Colitis: Implications for Detection and Transmission of COVID-19 Disease date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-354597-xubsodnk.txt cache: ./cache/cord-354597-xubsodnk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354597-xubsodnk.txt' === file2bib.sh === id: cord-355146-6rat5j64 author: Whittemore, Paul title: Use of awake proning to avoid invasive ventilation in a patient with severe COVID-19 pneumonitis date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-355146-6rat5j64.txt cache: ./cache/cord-355146-6rat5j64.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355146-6rat5j64.txt' === file2bib.sh === id: cord-354168-omen8vvq author: Al Saleh, Abdullah S. title: Multiple Myeloma in the Time of COVID-19 date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-354168-omen8vvq.txt cache: ./cache/cord-354168-omen8vvq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-354168-omen8vvq.txt' === file2bib.sh === id: cord-354372-vfvnjmv1 author: Carpenito, L. title: The autopsy at the time of SARS-CoV-2: Protocol and lessons date: 2020-07-04 pages: extension: .txt txt: ./txt/cord-354372-vfvnjmv1.txt cache: ./cache/cord-354372-vfvnjmv1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-354372-vfvnjmv1.txt' === file2bib.sh === id: cord-355264-ygzh8von author: Florez-Perdomo, William Andrés title: Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: a systematic review and meta-analysis date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-355264-ygzh8von.txt cache: ./cache/cord-355264-ygzh8von.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355264-ygzh8von.txt' === file2bib.sh === id: cord-355885-pg6mpuk5 author: Saracoglu, Kemal T. title: Airway management strategies for the Covid 19 patients: A brief narrative review date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-355885-pg6mpuk5.txt cache: ./cache/cord-355885-pg6mpuk5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355885-pg6mpuk5.txt' === file2bib.sh === id: cord-354411-4emzxu09 author: Nouvenne, Antonio title: Lung Ultrasound in COVID-19 Pneumonia: Correlations with Chest CT on Hospital admission date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-354411-4emzxu09.txt cache: ./cache/cord-354411-4emzxu09.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-354411-4emzxu09.txt' === file2bib.sh === id: cord-353594-z1vxamvp author: Gagiannis, Daniel title: Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD) date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-353594-z1vxamvp.txt cache: ./cache/cord-353594-z1vxamvp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-353594-z1vxamvp.txt' === file2bib.sh === id: cord-355533-5kgdg2nb author: Kline, Jonathan D title: Sentinel Case of COVID-19 at Fort Stewart, GA in a National Guard Soldier Participating in Annual Training: A Case Report date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-355533-5kgdg2nb.txt cache: ./cache/cord-355533-5kgdg2nb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355533-5kgdg2nb.txt' === file2bib.sh === id: cord-355191-jghvq3cy author: Yang, Yang title: A Rare Case of Immune Thrombocytopenic Purpura Secondary to COVID‐19 date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-355191-jghvq3cy.txt cache: ./cache/cord-355191-jghvq3cy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355191-jghvq3cy.txt' === file2bib.sh === id: cord-354337-a70avg2x author: Mehraeen, Esmaeil title: A systematic review of ECG findings in patients with COVID-19 date: 2020-11-13 pages: extension: .txt txt: ./txt/cord-354337-a70avg2x.txt cache: ./cache/cord-354337-a70avg2x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354337-a70avg2x.txt' === file2bib.sh === id: cord-355524-qx396wq1 author: Rao, P Vishnu title: Clinical profile of respiratory viral infections: A study from tertiary care centre of South India date: 2017-09-30 pages: extension: .txt txt: ./txt/cord-355524-qx396wq1.txt cache: ./cache/cord-355524-qx396wq1.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355524-qx396wq1.txt' === file2bib.sh === id: cord-354689-dsv63it1 author: Chen, Qian title: Precautionary Measures: Performing ERCP on a Patient With Juxtapapillary Duodenal Diverticula (JPDD)-Related Biliary Stone After COVID-19 Lockdown Restriction Lifted in Wuhan, China date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-354689-dsv63it1.txt cache: ./cache/cord-354689-dsv63it1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-354689-dsv63it1.txt' === file2bib.sh === id: cord-354619-pftjhtpo author: Farronato, Marco title: A Call for Action to Safely Deliver Oral Health Care during and Post COVID-19 Pandemic date: 2020-09-15 pages: extension: .txt txt: ./txt/cord-354619-pftjhtpo.txt cache: ./cache/cord-354619-pftjhtpo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354619-pftjhtpo.txt' === file2bib.sh === id: cord-355558-r6r1t47c author: Shenoy, Akhil title: Diabetes and covid-19: a global health challenge date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-355558-r6r1t47c.txt cache: ./cache/cord-355558-r6r1t47c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355558-r6r1t47c.txt' === file2bib.sh === id: cord-353484-q7d0ysbo author: Liu, Xue title: COVID-19: Progress in diagnostics, therapy and vaccination date: 2020-06-19 pages: extension: .txt txt: ./txt/cord-353484-q7d0ysbo.txt cache: ./cache/cord-353484-q7d0ysbo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-353484-q7d0ysbo.txt' === file2bib.sh === id: cord-356379-e8ohc25w author: Wu, Qiuji title: Recovery from COVID‐19 in two patients with coexisted HIV infection date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-356379-e8ohc25w.txt cache: ./cache/cord-356379-e8ohc25w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-356379-e8ohc25w.txt' === file2bib.sh === id: cord-355028-1x7w1749 author: Piazza, Cesare title: Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society date: 2020-06-06 pages: extension: .txt txt: ./txt/cord-355028-1x7w1749.txt cache: ./cache/cord-355028-1x7w1749.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355028-1x7w1749.txt' === file2bib.sh === id: cord-356127-xy5tyd7t author: Omidi, Negar title: Prosthetic heart valves and the COVID‐19 pandemic era: What should we be concerned about? date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-356127-xy5tyd7t.txt cache: ./cache/cord-356127-xy5tyd7t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-356127-xy5tyd7t.txt' === file2bib.sh === id: cord-355031-l0tj7kp2 author: Krenitsky, Nicole M. title: Primed for a Pandemic: Implementation of Telehealth Outpatient Monitoring for Women with Mild COVID-19 date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-355031-l0tj7kp2.txt cache: ./cache/cord-355031-l0tj7kp2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355031-l0tj7kp2.txt' === file2bib.sh === id: cord-356056-82bvcuvd author: Shaikh, Aasef G. title: Cerebellar Scholars’ Challenging Time in COVID-19 Pandemia date: 2020-04-16 pages: extension: .txt txt: ./txt/cord-356056-82bvcuvd.txt cache: ./cache/cord-356056-82bvcuvd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-356056-82bvcuvd.txt' === file2bib.sh === id: cord-355898-hlkwwaqe author: Grippo, Antonello title: Electroencephalography during SARS-CoV-2 outbreak: practical recommendations from the task force of the Italian Society of Neurophysiology (SINC), the Italian League Against Epilepsy (LICE), and the Italian Association of Neurophysiology Technologists (AITN) date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-355898-hlkwwaqe.txt cache: ./cache/cord-355898-hlkwwaqe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355898-hlkwwaqe.txt' === file2bib.sh === id: cord-355190-ytdw1d5v author: Mok, Chi Chiu title: Trend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years date: 2020-09-11 pages: extension: .txt txt: ./txt/cord-355190-ytdw1d5v.txt cache: ./cache/cord-355190-ytdw1d5v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355190-ytdw1d5v.txt' === file2bib.sh === id: cord-355504-zsyvgm9c author: Feng, Feng title: Longitudinal changes of pneumonia complicating novel influenza A (H1N1) by high-resolution computed tomography date: 2015-06-09 pages: extension: .txt txt: ./txt/cord-355504-zsyvgm9c.txt cache: ./cache/cord-355504-zsyvgm9c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-355504-zsyvgm9c.txt' === file2bib.sh === id: cord-355484-2igc5wzx author: Oteo, J. A. title: A short therapeutic regimen based on hydroxychloroquine plus azithromycin for the treatment of COVID-19 in patients with non-severe disease. A strategy associated with a reduction in hospital admissions and complications. date: 2020-06-12 pages: extension: .txt txt: ./txt/cord-355484-2igc5wzx.txt cache: ./cache/cord-355484-2igc5wzx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355484-2igc5wzx.txt' === file2bib.sh === id: cord-356371-w9ejgzvu author: Torres-González, JI title: What has happened to care during the COVID-19 pandemic? date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-356371-w9ejgzvu.txt cache: ./cache/cord-356371-w9ejgzvu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-356371-w9ejgzvu.txt' === file2bib.sh === id: cord-354720-fu19u2b0 author: White-Dzuro, Gabrielle title: Multisystem effects of COVID-19: a concise review for practitioners date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-354720-fu19u2b0.txt cache: ./cache/cord-354720-fu19u2b0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-354720-fu19u2b0.txt' === file2bib.sh === id: cord-354216-4khdcjed author: Sultan, Shahnaz title: AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19 date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-354216-4khdcjed.txt cache: ./cache/cord-354216-4khdcjed.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-354216-4khdcjed.txt' === file2bib.sh === id: cord-356332-t0ahmh0h author: Elkattawy, Sherif title: A Rare Complication of Myocardial Infarction: Ventricular Septal Defect date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-356332-t0ahmh0h.txt cache: ./cache/cord-356332-t0ahmh0h.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-356332-t0ahmh0h.txt' === file2bib.sh === id: cord-355177-62v1qhia author: Emery, Andrew Robert title: A Novel Approach to Fiberoptic Intubation in COVID-19 Patients date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-355177-62v1qhia.txt cache: ./cache/cord-355177-62v1qhia.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355177-62v1qhia.txt' === file2bib.sh === id: cord-355033-txxylmrw author: frontera, Jennifer A. title: Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study date: 2020-10-26 pages: extension: .txt txt: ./txt/cord-355033-txxylmrw.txt cache: ./cache/cord-355033-txxylmrw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355033-txxylmrw.txt' === file2bib.sh === id: cord-355549-6xnjj5h5 author: Cécile, Couchoud title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-355549-6xnjj5h5.txt cache: ./cache/cord-355549-6xnjj5h5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355549-6xnjj5h5.txt' === file2bib.sh === id: cord-354194-hf5ndv5f author: Cook, Mackenzie title: Prioritizing Communication in the Provision of Palliative Care for the Trauma Patient date: 2020-10-29 pages: extension: .txt txt: ./txt/cord-354194-hf5ndv5f.txt cache: ./cache/cord-354194-hf5ndv5f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354194-hf5ndv5f.txt' === file2bib.sh === id: cord-355296-46jf56nc author: Goldstein, David P. title: Tracheoesophageal voice prosthesis management in laryngectomy patients during the COVID-19 pandemic date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-355296-46jf56nc.txt cache: ./cache/cord-355296-46jf56nc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-355296-46jf56nc.txt' === file2bib.sh === id: cord-355294-gifsqph6 author: García-Suárez, Julio title: Impact of hematologic malignancy and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-355294-gifsqph6.txt cache: ./cache/cord-355294-gifsqph6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355294-gifsqph6.txt' === file2bib.sh === id: cord-356084-621qzpqd author: Qu, Jiuxin title: Profile of IgG and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-356084-621qzpqd.txt cache: ./cache/cord-356084-621qzpqd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-356084-621qzpqd.txt' === file2bib.sh === id: cord-356246-4p0ok1mc author: Ammirati, Enrico title: Heart-Kidney Transplanted patient affected by COVID-19 pneumonia treated with tocilizumab on top of immunosuppressive maintenance therapy date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-356246-4p0ok1mc.txt cache: ./cache/cord-356246-4p0ok1mc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-356246-4p0ok1mc.txt' === file2bib.sh === id: cord-355039-qi4fwqbc author: Azar, William S. title: COVID-19 and diabetes mellitus: how one pandemic worsens the other date: 2020-08-02 pages: extension: .txt txt: ./txt/cord-355039-qi4fwqbc.txt cache: ./cache/cord-355039-qi4fwqbc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355039-qi4fwqbc.txt' === file2bib.sh === id: cord-355431-efwuy8p9 author: Ambrosio, Luca title: The role of the orthopaedic surgeon in the COVID-19 era: cautions and perspectives date: 2020-05-27 pages: extension: .txt txt: ./txt/cord-355431-efwuy8p9.txt cache: ./cache/cord-355431-efwuy8p9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355431-efwuy8p9.txt' === file2bib.sh === id: cord-350923-532lnnll author: Ramalho, Renata title: Immunometabolism: new insights and lessons from antigen-directed cellular immune responses date: 2020-06-09 pages: extension: .txt txt: ./txt/cord-350923-532lnnll.txt cache: ./cache/cord-350923-532lnnll.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350923-532lnnll.txt' === file2bib.sh === id: cord-356040-qdpkidn8 author: Ghazawi, Feras M. title: Infection risk of dermatologic therapeutics during the COVID‐19 pandemic: an evidence‐based recalibration date: 2020-07-03 pages: extension: .txt txt: ./txt/cord-356040-qdpkidn8.txt cache: ./cache/cord-356040-qdpkidn8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-356040-qdpkidn8.txt' === file2bib.sh === id: cord-356195-5pcaxpp9 author: Jothimani, Dinesh title: COVID-19 and Liver. date: 2020-06-15 pages: extension: .txt txt: ./txt/cord-356195-5pcaxpp9.txt cache: ./cache/cord-356195-5pcaxpp9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-356195-5pcaxpp9.txt' === file2bib.sh === id: cord-356349-ey5vnddu author: Fusco, Francesco M title: Infection control management of patients with suspected highly infectious diseases in emergency departments: data from a survey in 41 facilities in 14 European countries date: 2012-01-28 pages: extension: .txt txt: ./txt/cord-356349-ey5vnddu.txt cache: ./cache/cord-356349-ey5vnddu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-356349-ey5vnddu.txt' === file2bib.sh === id: cord-355384-qa7grviy author: NaserEddin, Adeeb title: Bacillus Calmette–Guerin (BCG) Vaccine-associated Complications in Immunodeficient Patients Following Stem Cell Transplantation date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-355384-qa7grviy.txt cache: ./cache/cord-355384-qa7grviy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355384-qa7grviy.txt' === file2bib.sh === id: cord-356215-0nypfw48 author: Hu, Xiaojing title: Management practices of emergency departments in general hospitals based on blockage of chain of infection during a COVID-19 epidemic date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-356215-0nypfw48.txt cache: ./cache/cord-356215-0nypfw48.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-356215-0nypfw48.txt' === file2bib.sh === id: cord-354658-v451z3jq author: Rajagopal, Keshava title: Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-354658-v451z3jq.txt cache: ./cache/cord-354658-v451z3jq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-354658-v451z3jq.txt' === file2bib.sh === id: cord-355589-3zdv9zim author: Simons, David title: The association of smoking status with SARS‐CoV‐2 infection, hospitalisation and mortality from COVID‐19: A living rapid evidence review with Bayesian meta‐analyses (version 7) date: 2020-10-02 pages: extension: .txt txt: ./txt/cord-355589-3zdv9zim.txt cache: ./cache/cord-355589-3zdv9zim.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355589-3zdv9zim.txt' === file2bib.sh === id: cord-355528-y4a1g6km author: Balla, Mamtha title: COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective date: 2020-03-30 pages: extension: .txt txt: ./txt/cord-355528-y4a1g6km.txt cache: ./cache/cord-355528-y4a1g6km.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-355528-y4a1g6km.txt' === file2bib.sh === id: cord-356057-87kxlqdc author: Chagas, Aline Lopes title: Management of Hepatocellular Carcinoma during the COVID-19 Pandemic - São Paulo Clínicas Liver Cancer Group Multidisciplinary Consensus Statement date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-356057-87kxlqdc.txt cache: ./cache/cord-356057-87kxlqdc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-356057-87kxlqdc.txt' === file2bib.sh === id: cord-354824-7fdcu2f0 author: Wu, Renyi title: An Update on Current Therapeutic Drugs Treating COVID-19 date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-354824-7fdcu2f0.txt cache: ./cache/cord-354824-7fdcu2f0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-354824-7fdcu2f0.txt' === file2bib.sh === id: cord-353671-xjpzhsup author: Sgouros, George title: Radiopharmaceutical therapy in cancer: clinical advances and challenges date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-353671-xjpzhsup.txt cache: ./cache/cord-353671-xjpzhsup.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-353671-xjpzhsup.txt' === file2bib.sh === id: cord-344131-e7phs0jd author: Ford, Richard B. title: Section 4 Diagnostic and Therapeutic Procedures date: 2012-12-31 pages: extension: .txt txt: ./txt/cord-344131-e7phs0jd.txt cache: ./cache/cord-344131-e7phs0jd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-344131-e7phs0jd.txt' === file2bib.sh === id: cord-009997-oecpqf1j author: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 pages: extension: .txt txt: ./txt/cord-009997-oecpqf1j.txt cache: ./cache/cord-009997-oecpqf1j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 22 resourceName b'cord-009997-oecpqf1j.txt' === file2bib.sh === id: cord-000718-7whai7nr author: nan title: ESP Abstracts 2012 date: 2012-08-22 pages: extension: .txt txt: ./txt/cord-000718-7whai7nr.txt cache: ./cache/cord-000718-7whai7nr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 16 resourceName b'cord-000718-7whai7nr.txt' === file2bib.sh === id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 pages: extension: .txt txt: ./txt/cord-335975-m6lkrehi.txt cache: ./cache/cord-335975-m6lkrehi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-335975-m6lkrehi.txt' === file2bib.sh === id: cord-022888-dnsdg04n author: nan title: Poster Sessions date: 2009-08-19 pages: extension: .txt txt: ./txt/cord-022888-dnsdg04n.txt cache: ./cache/cord-022888-dnsdg04n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 13 resourceName b'cord-022888-dnsdg04n.txt' === file2bib.sh === id: cord-341063-3rqnu5bu author: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 pages: extension: .txt txt: ./txt/cord-341063-3rqnu5bu.txt cache: ./cache/cord-341063-3rqnu5bu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-341063-3rqnu5bu.txt' === file2bib.sh === id: cord-350571-6tapkjb6 author: nan title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 pages: extension: .txt txt: ./txt/cord-350571-6tapkjb6.txt cache: ./cache/cord-350571-6tapkjb6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-350571-6tapkjb6.txt' === file2bib.sh === id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 pages: extension: .txt txt: ./txt/cord-355038-o2hr5mox.txt cache: ./cache/cord-355038-o2hr5mox.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-355038-o2hr5mox.txt' === file2bib.sh === id: cord-023211-kt5gt26t author: nan title: Poster Session Abstracts date: 2007-08-29 pages: extension: .txt txt: ./txt/cord-023211-kt5gt26t.txt cache: ./cache/cord-023211-kt5gt26t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 24 resourceName b'cord-023211-kt5gt26t.txt' === file2bib.sh === id: cord-015324-y44sfr0c author: nan title: Scientific Programme date: 2007-09-01 pages: extension: .txt txt: ./txt/cord-015324-y44sfr0c.txt cache: ./cache/cord-015324-y44sfr0c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 29 resourceName b'cord-015324-y44sfr0c.txt' === file2bib.sh === id: cord-031907-ilhr3iu5 author: nan title: ISEV2020 Abstract Book date: 2020-07-15 pages: extension: .txt txt: ./txt/cord-031907-ilhr3iu5.txt cache: ./cache/cord-031907-ilhr3iu5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 17 resourceName b'cord-031907-ilhr3iu5.txt' === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes id: cord-010092-uftc8inx author: nan title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 pages: extension: .txt txt: ./txt/cord-010092-uftc8inx.txt cache: ./cache/cord-010092-uftc8inx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 15 resourceName b'cord-010092-uftc8inx.txt' === file2bib.sh === id: cord-015354-yknwveyz author: nan title: Abstracts_Poster presentations date: 2007-09-18 pages: extension: .txt txt: ./txt/cord-015354-yknwveyz.txt cache: ./cache/cord-015354-yknwveyz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 19 resourceName b'cord-015354-yknwveyz.txt' === file2bib.sh === id: cord-006849-vgjz74ts author: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 pages: extension: .txt txt: ./txt/cord-006849-vgjz74ts.txt cache: ./cache/cord-006849-vgjz74ts.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 22 resourceName b'cord-006849-vgjz74ts.txt' === file2bib.sh === id: cord-010119-t1x9gknd author: nan title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 pages: extension: .txt txt: ./txt/cord-010119-t1x9gknd.txt cache: ./cache/cord-010119-t1x9gknd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-010119-t1x9gknd.txt' === file2bib.sh === id: cord-022940-atbjwpo5 author: nan title: Poster Sessions date: 2016-09-07 pages: extension: .txt txt: ./txt/cord-022940-atbjwpo5.txt cache: ./cache/cord-022940-atbjwpo5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 19 resourceName b'cord-022940-atbjwpo5.txt' === file2bib.sh === id: cord-005453-4057qib7 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 pages: extension: .txt txt: ./txt/cord-005453-4057qib7.txt cache: ./cache/cord-005453-4057qib7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 30 resourceName b'cord-005453-4057qib7.txt' === file2bib.sh === id: cord-005460-ezrn8cva author: nan title: Physicians – Poster Session date: 2017-07-28 pages: extension: .txt txt: ./txt/cord-005460-ezrn8cva.txt cache: ./cache/cord-005460-ezrn8cva.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 20 resourceName b'cord-005460-ezrn8cva.txt' Que is empty; done keyword-patient-cord === reduce.pl bib === id = cord-000001-ug7v899j author = Madani, Tariq A title = Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia date = 2001-07-04 pages = extension = .txt mime = text/plain words = 2455 sentences = 140 flesch = 41 summary = title: Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia OBJECTIVE: This retrospective chart review describes the epidemiology and clinical features of 40 patients with culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. CONCLUSION: our results were similar to published data except for the finding that infections were more common in infants and preschool children and that the mortality rate of pneumonia in patients with comorbidities was high. Mycoplasma pneumoniae is a common cause of upper and lower respiratory tract infections. pneumoniae infections in Saudi Arabia is scarce, [8, 9, 10] we wished to study the epidemiology and clinical features of cultureproven infections caused by this organism at this hospital. pneumoniae culture were obtained from patients with upper or lower respiratory tract infections seen as inpatients or in the outpatient or emergency departments. Role of Mycoplasma pneumoniae in acute respiratory-tract infections in Saudi paediatric patients cache = ./cache/cord-000001-ug7v899j.txt txt = ./txt/cord-000001-ug7v899j.txt === reduce.pl bib === id = cord-001313-f72hl6du author = Toncheva, D. title = NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy date = 2014-05-15 pages = extension = .txt mime = text/plain words = 3648 sentences = 217 flesch = 40 summary = Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression leading to terminal renal failure. Mutant genes (CELA1, HSPG2, and KCNK5) in BEN patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis. Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression to terminal renal failure. In the present study we aimed to perform exome sequencing of 22 000 genes with the Illumina Nextera Exome Enrichment Kit using NGS technology in order to find specific mutations for BEN. have intensively studied the pathological changes in the kidneys of BEN patients and presented evidence that renal vascular changes occur early in Balkan nephropathy [30] . MDR1 haplotypes modify BEN disease risk: a study in Bulgarian patients with Balkan endemic nephropathy compared to healthy controls cache = ./cache/cord-001313-f72hl6du.txt txt = ./txt/cord-001313-f72hl6du.txt === reduce.pl bib === id = cord-000831-zwfxnd7r author = Bakhshayeshkaram, Mehrdad title = Imaging Findings in Patients With H1N1 Influenza A Infection date = 2011-12-25 pages = extension = .txt mime = text/plain words = 2285 sentences = 149 flesch = 53 summary = The initial radiography obtained from the patients was reviewed regarding pattern (consolidation, ground glass, nodules and reticulation), distribution (focal, multifocal, and diffuse) and the lung zones involved. CONCLUSIONS: In patients with the novel swine flu infection, the most common radiographic abnormality observed was consolidation in the lower lung zones. In a study on 66 patients, the most common abnormal pattern was consolidation most commonly observed in the lower and central lung zones and patients admitted to the ICU were more likely to have three or more lung zones involved (4). In their study, patients with bilateral and peripheral involvement or four or more lung zone involvement were more likely to have severe outcome, which is in consistence with our findings in patients admitted to ICU. Another study reviewed the High Resolution Computed Tomography Scan (HRCT) findings of 18 patients with the new swine flu influenza. cache = ./cache/cord-000831-zwfxnd7r.txt txt = ./txt/cord-000831-zwfxnd7r.txt === reduce.pl bib === id = cord-000308-cxr1ul7q author = Cianchi, Giovanni title = Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date = 2011-01-11 pages = extension = .txt mime = text/plain words = 4325 sentences = 239 flesch = 42 summary = BACKGROUND: Since the first outbreak of a respiratory illness caused by H1N1 virus in Mexico, several reports have described the need of intensive care or extracorporeal membrane oxygenation (ECMO) assistance in young and often healthy patients. Since the first outbreak of a respiratory illness caused by Influenza A (H1N1) virus in Mexico [1] , several reports have described the need of intensive care [2] [3] [4] or extracorporeal membrane oxygenation (ECMO) assistance [5] in young and often healthy patients. In the present investigation we report our experience, as an ECMO referral center, in H1N1-induced acute respiratory distress syndrome (ARDS) and we present the critical care service planning in response to the H1N1 pandemic. List of abbreviations ARDS: acute respiratory distress syndrome; BMI: body mass index; CVVH: continuous veno-venous hemofiltration; ECMO: extracorporeal membrane oxygenation; ICU: intensive care unit; LOS: length of stay; LUS: lung ultrasound; RT-PCR: real-time reverse transcriptase-polymerase-chain-reaction; SAPS: simplified acute physiology score. cache = ./cache/cord-000308-cxr1ul7q.txt txt = ./txt/cord-000308-cxr1ul7q.txt === reduce.pl bib === id = cord-002782-mena480g author = Chen, Jiajia title = Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection date = 2017-12-08 pages = extension = .txt mime = text/plain words = 3021 sentences = 179 flesch = 55 summary = Our findings suggest that pulmonary function and imaging findings improved during the first 6 months especially for those with ARDS, however long-term lung disability and psychological impairment in H7N9 survivors persisted at 2 years after discharge from the hospital. In survivors of H5N1 virus infection, radiologic abnormalities including ground-glass opacities with a reticular pattern remained evident at the 12-month follow-up visit 10 . A study of the long-term outcomes of survivors with ARDS reported a mild restrictive pattern on lung-function testing, with a mild-to-moderate reduction in carbon monoxide diffusion capacity at 3 months; The median DLCO improved by 9% of the predicted value from 3 to 12 months 13 . A meta-analysis showed that recovery in the HRQoL of ARDS survivors occurred during the first 6 months after discharge 20 , but no significant improvement was evident at the 2-year follow-up in our study. Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge cache = ./cache/cord-002782-mena480g.txt txt = ./txt/cord-002782-mena480g.txt === reduce.pl bib === id = cord-000229-9fr0m92p author = Yun, Tae Jin title = Radiological and Clinical Characteristics of a Military Outbreak of Pandemic H1N1 2009 Influenza Virus Infection date = 2010-06-21 pages = extension = .txt mime = text/plain words = 3214 sentences = 137 flesch = 45 summary = However, six of 12 patients who underwent thin-section CT examinations showed abnormal findings for small ground-glass opacities (GGOs) in addition to poorly-defined nodules with upper lobe predominance. CONCLUSION: In a population of healthy young adults, elevated CRP with normal ESR and white blood cell levels combined with GGOs and nodules on thin-section CT scans may indicate early signs of infection by the pandemic H1N1 2009 influenza virus. In this article, we aim to describe detailed clinical characteristics and radiologic features of chest radiographs and thin-section CT findings of patients confirmed with the pandemic H1N1 2009 influenza virus infection occurring in a semi-closed setting. Most patients in our study did not show a severe hospital course, although one patient's symptoms aggravated into ARDS and needed mechanical ventilation before laboratory tests revealed that he had the pandemic H1N1 2009 influenza virus infection. cache = ./cache/cord-000229-9fr0m92p.txt txt = ./txt/cord-000229-9fr0m92p.txt === reduce.pl bib === id = cord-002977-o0dvwzxk author = Gosangi, Babina title = Review of targeted therapy in chronic lymphocytic leukemia: what a radiologist needs to know about CT interpretation date = 2018-04-18 pages = extension = .txt mime = text/plain words = 5462 sentences = 239 flesch = 36 summary = Using CLL as a case study, we present a timeline and overview of the current treatment landscape for the radiologist, including an overview of clinical and radiological features of CLL, discussion of the targeted agents themselves, and the role of imaging in response and toxicity assessment. In this review, using CLL as a case study, we summarize the clinical and radiological features of this disease and discuss the various targeted therapies used to treat CLL and other indolent lymphomas, with emphasis on the role of imaging in toxicity assessment. Despite these potential toxicities, each of Fig. 9 a 78-year-old female patient with CLL on treatment with Idelalisib with pneumonitis, axial CT of the chest obtained in arterial phase demonstrates bilateral patchy areas of ground glass and consolidative opacities. cache = ./cache/cord-002977-o0dvwzxk.txt txt = ./txt/cord-002977-o0dvwzxk.txt === reduce.pl bib === id = cord-000716-fhm8abxp author = Wang, Hao title = Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics date = 2012-07-11 pages = extension = .txt mime = text/plain words = 2770 sentences = 154 flesch = 45 summary = BACKGROUND: In the present study, the whole human genome oligo microarray was employed to investigate the gene expression profile in symptomatic pulmonary embolism (PE). Gene Ontology analysis showed the genes with down-regulated expressions mainly explain the compromised T cell immunity. However, mRNA expression of P-selectin (mainly distributed on the surface of ECs and platelets) and E-selection (mainly distributed on the surface of activated ECs) are not elevated in PE group which indicate venous endothelial cells are not impaired in patients with PE (Fig.2) . Gene ontology analysis exhibited compromised T cell mediated immune function, and t test indicated associated genes were significantly down-regulated in patients with PE than in control groups. Two genes with down-regulated expressions are closely related to the T cell mediated immunity according to GO analysis (with high value of Enrichment). Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study cache = ./cache/cord-000716-fhm8abxp.txt txt = ./txt/cord-000716-fhm8abxp.txt === reduce.pl bib === id = cord-000284-00rk8fb5 author = Hajjar, L. A. title = Severe novel influenza A (H1N1) infection in cancer patients date = 2010-05-28 pages = extension = .txt mime = text/plain words = 3714 sentences = 222 flesch = 44 summary = Conclusions: H1N1 viral infection in patients with cancer can cause severe illness, resulting in acute respiratory distress syndrome and death. However, patients with comorbidities as cancer and chronic diseases may show a serious clinical presentation, characterized by respiratory failure with variable severity [6, 7] . In this study, we describe the clinical and pathological findings in critically ill patients with cancer and respiratory failure related to novel H1N1 infection admitted to original article an oncologic intensive care unit (ICU) in a reference cancer center in Sao Paulo, Brazil. We report the clinical and pathological findings from eight patients with cancer and severe H1N1 infection who were admitted to an oncologic ICU during the winter period of the 2009 pandemic in Sao Paulo, Brazil. The serious clinical presentation of the novel Influenza A (H1N1) infection in some cancer patients should be expected. cache = ./cache/cord-000284-00rk8fb5.txt txt = ./txt/cord-000284-00rk8fb5.txt === reduce.pl bib === id = cord-000522-d498qj2b author = Vincent, Jean-Louis title = Reducing mortality in sepsis: new directions date = 2002-12-05 pages = extension = .txt mime = text/plain words = 8709 sentences = 431 flesch = 48 summary = Five topics were selected that have been shown in randomized, controlled trials to reduce mortality: limiting the tidal volume in acute lung injury or acute respiratory distress syndrome, early goal-directed therapy, use of drotrecogin alfa (activated), use of moderate doses of steroids, and tight control of blood sugar. The present article provides guidelines from experts in the field on optimal patient selection and timing for each intervention, and provides advice on how to integrate new therapies into ICU practice, including protocol development, so that mortality rates from this disease process can be reduced. The interventions discussed encompassed low tidal volume in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) (Edward Abraham), early goal-directed therapy (EGDT) (Emanuel Rivers), drotrecogin alfa (activated) (Gordon Bernard), moderate-dose corticosteroids (Djillali Annane), and tight control of blood sugar (Greet Van den Berghe). cache = ./cache/cord-000522-d498qj2b.txt txt = ./txt/cord-000522-d498qj2b.txt === reduce.pl bib === id = cord-003533-8m0vyxq8 author = Jayathilaka, P. G. N. S. title = An outbreak of leptospirosis with predominant cardiac involvement: a case series date = 2019-03-18 pages = extension = .txt mime = text/plain words = 4148 sentences = 280 flesch = 50 summary = We present a case series of severe leptospirosis with cardiac involvement observed during a period of one month at Colombo-North Teaching Hospital, Sri Lanka. CASE PRESENTATION: We report here five patients with severe leptospirosis complicated with cardiac involvement, admitted to a single medical ward, Colombo-North Teaching Hospital, Sri Lanka during a one-month period. In this case series, we describe a series of male patients with severe leptospirosis with cardiac involvement, presented to a single medical ward during a period of one month. By day eleven of illness he was completely recovered clinically and full blood count, liver function tests, renal function tests and ECG were normal. Patient was discharged from the ward on day 7 of illness with complete recovery and normal full blood count, renal and liver function tests. Despite adequate fluid resuscitation patient developed shock with low urine output on the same day of admission. cache = ./cache/cord-003533-8m0vyxq8.txt txt = ./txt/cord-003533-8m0vyxq8.txt === reduce.pl bib === id = cord-002240-38aabxh1 author = Prina, Elena title = New aspects in the management of pneumonia date = 2016-10-01 pages = extension = .txt mime = text/plain words = 4832 sentences = 216 flesch = 35 summary = The administration of intravenous immunoglobulins seems to reinforce the immune response to the infection in particular in patients with inadequate levels of antibodies and when an enriched IgM preparation has been used; however, more studies are needed to determinate their impact on outcome and to define the population that will receive more benefit. Despite the use of early and appropriate antibiotic treatment, mortality related to community-acquired pneumonia (CAP) is still high [1] , especially in patients with severe disease. In contrast, another meta-analysis [25] demonstrated a reduction in all causes of mortality in patients receiving corticosteroids (12 trials, 1974 In conclusion, all these studies confirm that the use of corticosteroids in CAP is associated with the following benefits: reduced length of hospital stay, reduced time to clinical stability, and prevention of ARDS. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial cache = ./cache/cord-002240-38aabxh1.txt txt = ./txt/cord-002240-38aabxh1.txt === reduce.pl bib === id = cord-002514-pp06m5xk author = Venkatesan, Sudhir title = Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis date = 2017-05-15 pages = extension = .txt mime = text/plain words = 4019 sentences = 173 flesch = 40 summary = title: Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis While evidence exists to support the effectiveness of neuraminidase inhibitors (NAIs) in reducing mortality when given to hospitalized patients with A(H1N1)pdm09 virus infection, the impact of outpatient treatment on hospitalization has not been clearly established. In patients with laboratory-confirmed or clinically diagnosed A(H1N1)pdm09 influenza, after adjustment for community-based antibiotic treatment and propensity score, the likelihood of hospital admission in patients with outpatient or community-based NAI treatment was 0.24 (95% CI, 0.20-0.30) when compared to no NAI treatment in the community (Table 2) . Our main findings ( Table 2) suggest that NAI treatment in the community for patients with severe pandemic influenza substantially reduced the likelihood of hospital admission due to influenza A(H1N1)pdm09. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data cache = ./cache/cord-002514-pp06m5xk.txt txt = ./txt/cord-002514-pp06m5xk.txt === reduce.pl bib === id = cord-004379-91a7sgir author = Han, Nayoung title = Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews date = 2020-02-20 pages = extension = .txt mime = text/plain words = 3261 sentences = 190 flesch = 46 summary = The aim of this study was to evaluate age-related clinical manifestations of adverse events (AEs) related to NAIs. FAERS and WebMD data were downloaded. A disproportionality analysis showed that signals for vomiting and hallucinations were detected in younger patients given oseltamivir, while an abnormal hepatic function, cardiac failure, shock, and cardio-respiratory arrest were detected in older patients given peramivir. However, there is still concern regarding the adverse effects of NAIs. This study analyzed the age-related AEs associated with NAIs using data from FAERS and WebMD. Oseltamivir was the NAI most commonly showing AEs in the FAERS data, and the most common AEs for this drug were psychiatric and gastrointestinal disorders, similar to the findings of previous studies 8, [13] [14] [15] [16] . However, in the WebMD data, we could not detect signals by these disproportionality analyses due to the small number of AE cases, although psychiatric and gastrointestinal disorders were the most common AEs reported. cache = ./cache/cord-004379-91a7sgir.txt txt = ./txt/cord-004379-91a7sgir.txt === reduce.pl bib === id = cord-001421-6t5puo6p author = Marfà, Santiago title = Lack of a 5.9 kDa Peptide C-Terminal Fragment of Fibrinogen α Chain Precedes Fibrosis Progression in Patients with Liver Disease date = 2014-10-02 pages = extension = .txt mime = text/plain words = 5057 sentences = 229 flesch = 46 summary = The serum proteomic profile and routine liver and renal function tests were initially analyzed in a training set of 10 HCV-RNA recurrent LT patients 6 months post LT that showed a fibrosis stage F$1 at 1 year after LT. HVPG was assessed in 53 of these patients and the average value was of 5.560.8 mm Hg. All the serum samples showed a quite similar expression pattern and coincidences included both the different peptide fragments detected and the signal intensity of these fragments (Data S4). All serum samples included in the test set showed an intensity m/z 5905 peak well below the values found in both healthy subjects and non recurrent HCV patients. In conclusion, we identified a 5.9 kDa C-terminal fragment of the fibrinogen a chain as a serum biomarker of early fibrogenic processes in patients with liver disease. In conclusion, we identified a 5.9 kDa C-terminal fragment of the fibrinogen a chain as a serum biomarker of early fibrogenic processes in patients with liver disease. cache = ./cache/cord-001421-6t5puo6p.txt txt = ./txt/cord-001421-6t5puo6p.txt === reduce.pl bib === id = cord-002294-qa8e90qv author = Hayakawa, Sho title = Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial date = 2016-11-07 pages = extension = .txt mime = text/plain words = 4522 sentences = 232 flesch = 47 summary = title: Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial The administration of recombinant human soluble thrombomodulin (rhTM), which has both anti-inflammatory and anticoagulant activities, improves outcomes and respiratory function in patients with acute respiratory distress syndrome. Study data were compared with historical untreated comparison group, including 13 patients with AE-IPF who were treated without rhTM before the registration. Recombinant human soluble thrombomodulin (rhTM) demonstrates anticoagulation effects superior to heparin for the treatment of disseminated intravascular coagulation (DIC) [12] and improves the outcomes and respiratory functions in patients with sepsis-induced acute respiratory distress syndrome (ARDS) [13] . The patients who met any of the following conditions were excluded: 1) those with previous history of AE-IPF; 2) who was receiving corticosteroids or immunosuppressants; 3) who was receiving anti-coagulant therapy; 4) who had intracranial hemorrhage, pulmonary hemorrhage and/or gastrointestinal hemorrhage; 5) those with previous history of hypersensitivity against thrombomodulin; 6) those with active infectious disease; and 7) who was or possibly pregnant at the time of registration. cache = ./cache/cord-002294-qa8e90qv.txt txt = ./txt/cord-002294-qa8e90qv.txt === reduce.pl bib === id = cord-000457-e50a0suk author = Rhim, Jung-Woo title = Epidemiological and clinical characteristics of childhood pandemic 2009 H1N1 virus infection: an observational cohort study date = 2011-08-24 pages = extension = .txt mime = text/plain words = 3745 sentences = 182 flesch = 48 summary = METHODS: We evaluated the epidemiologic characteristics of all the subjects infected with the 2009 H1N1 influenza A virus (2,971 patients, ≤ 15 years of age), and the clinical and laboratory findings of the inpatients (217 patients, 80 had pneumonia) between 1 September 2009 and 31 January 2010 in a single hospital throughout the epidemic. In addition, during the study period we observed a dramatic effect of early treatment with corticosteroids and oseltamivir for patients with severe pneumonia including rapidly progressive pneumonia [9, 10] . We retrospectively evaluated all patients with 2009 H1N1 virus infection during the pandemic (2,971 patients) for epidemiologic characteristics, and for clinical characteristics, we reviewed the medical records and chest radiographic findings of 217 children admitted to The Catholic University of Korea, Daejeon St Mary's Hospital between 1 September 2009 and 31 January 2010. In pandemic 2009 H1N1 virus infections, children of all ages were evenly affected, and males were predominant in pneumonia patients. cache = ./cache/cord-000457-e50a0suk.txt txt = ./txt/cord-000457-e50a0suk.txt === reduce.pl bib === id = cord-004986-en7taikk author = Nagy, Nathalie title = Infections gastro-intestinales chez le patient immunocompromis date = 2002 pages = extension = .txt mime = text/plain words = 6147 sentences = 672 flesch = 58 summary = Dans 44 h 68 % des patients sida prEsentant une entEropathie due ~un ou plusieurs agents pathogEnes concomitant, des symptEmes gastro-intestinaux sont retrouvEs. Le diagnostic d'infections opportunistes est en gEnEral base sur une combinaison de culture de selles, examen direct des selles ~ la recherche d'ceufs ou de larves, et d'une biopsie endoscopique. L'infection herpEtique semble 6tre plus frEquente chez le patient HIV que chez les autres patients immunodEprimEs. Dans une importante Etude prospective r6alisEe sur 100 patients HIV pr6sentant une cesophagite her-pEtique, le virus HSV n'a 6tE identifi6 que darts 5 % des cas alors que la prevalence du virus CMV atteignait 50 % [4] . Les infections ~ Campylobacter ont 6t6 identifi6es dans approximativement 11% des coprocultures des patients sida, qu'ils souffrent ou non de diarrh6es ; ces patients, pr6sentant une incidence d'infection, sont 39 fois plus importants que dans la population g6n6rale. Cependant une colonisation m6me par des agents non pathog6nes peut 8tre responsable d'affections s6vhres chez les patients immunocompromis [6] . cache = ./cache/cord-004986-en7taikk.txt txt = ./txt/cord-004986-en7taikk.txt === reduce.pl bib === id = cord-001322-7xmxcm35 author = Walden, Andrew P title = Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort date = 2014-04-01 pages = extension = .txt mime = text/plain words = 4286 sentences = 227 flesch = 47 summary = Phenotypic data was recorded using a robust clinical database allowing a contemporary analysis of the clinical characteristics, microbiology, outcomes and independent risk factors in patients with severe CAP admitted to ICUs across Europe. A number of more recent, larger studies have focussed on identifying patients with CAP at increased risk of severe sepsis and death, as well as those who may require ventilator or vasopressor support [3, [24] [25] [26] . The aim of the study reported here was to define the clinical characteristics, microbiological aetiology, outcomes and independent risk factors for mortality in a large, contemporary cohort of patients with severe CAP admitted to ICUs across Europe. The British Thoracic Society Research Committee and The Public HealthLaboratory Service: The aetiology, management and outcome of severe community-acquired pneumonia on the intensive care unit A five-year study of severe community-acquired pneumonia with emphasis on prognosis in patients admitted to an intensive care unit cache = ./cache/cord-001322-7xmxcm35.txt txt = ./txt/cord-001322-7xmxcm35.txt === reduce.pl bib === id = cord-003828-bhfghcby author = Zrzavy, Tobias title = Vaccination in Multiple Sclerosis: Friend or Foe? date = 2019-08-07 pages = extension = .txt mime = text/plain words = 5603 sentences = 277 flesch = 37 summary = In contrast to these case series, a case-control study (evidence class II) (48) including more than 440 patients with MS or optic neuritis and 950 controls without any underlying neuroimmunological disorder did not reveal an elevated risk for the development of MS or optic neuritis after immunization against hepatitis B, tetanus, influenza, measles/mumps/rubella, measles, or rubella (49) . While Hernan came to same results for immunization against influenza or tetanus in a case-control study (evidence class II), active immunization against hepatitis B was reported to pose a higher risk for MS (50) . A case-control study on vaccination against hepatitis B, influenza, polio, diphtheria, pertussis, tetanus, measles, mumps, rubella, Japanese encephalitis, meningitis, hepatitis A, varicella and rabies did not reveal an increased risk for the onset of ADEM in the time spans of 0-30 days and 61-180 days after vaccination, but between 31 and 60 days (78) . cache = ./cache/cord-003828-bhfghcby.txt txt = ./txt/cord-003828-bhfghcby.txt === reduce.pl bib === id = cord-003404-eqgc8v7y author = May, Win Lai title = Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children date = 2019-01-02 pages = extension = .txt mime = text/plain words = 4930 sentences = 289 flesch = 55 summary = We aimed to determine the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar. In vitro studies reported that monocytes from G6PD-deficient individuals had increased susceptibility to dengue virus serotype 2 infections along with higher viral replication [5, 6] . Herein, we investigated the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar. Out of 212 enrolled patients, 16 were excluded (2 did not have Glucose-6-phosphate dehydrogenase deficiency on dengue infection in children sufficient blood volume, 11 had a negative dengue result, and 3 lacked quantitative G6PD results). Severe dengue was not associated with a G6PD deficiency phenotype nor genotype variants whether we used a cut off of < 30% (i.e. only including hemizygous males and homozygous females) or a cut off of < 60%, corresponding to classes I to III of the WHO classification (Table 5) . cache = ./cache/cord-003404-eqgc8v7y.txt txt = ./txt/cord-003404-eqgc8v7y.txt === reduce.pl bib === id = cord-001617-ff3j7i7i author = Siqueira, André M title = Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India date = 2015-03-20 pages = extension = .txt mime = text/plain words = 7186 sentences = 306 flesch = 38 summary = BACKGROUND: The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complications. We have used a common protocol in order to prospectively follow vivax malaria patients admitted to two distinct reference centers located in Brazil and India, aiming to comprehensively characterize and compare the clinical complications of P. The influence of these factors could already be observed by comparing the descriptions of clinical epidemiology of complications associated with this infection from different sites, showing that in areas of higher transmission intensities, children are the most frequently affected population [18, 19, 39, 40] , while in areas of moderate and low intensities, adults contribute more to the proportion of severe cases [7, 14, 41] . cache = ./cache/cord-001617-ff3j7i7i.txt txt = ./txt/cord-001617-ff3j7i7i.txt === reduce.pl bib === id = cord-003520-f3jz59pt author = Arabi, Yaseen M. title = Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date = 2019-02-13 pages = extension = .txt mime = text/plain words = 4280 sentences = 211 flesch = 51 summary = title: Free Fatty Acids' Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial Objectives: The objectives of this study were to evaluate the clinical and nutritional correlates of high free fatty acids (FFAs) level in critically ill patients and the association with outcomes, and to study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. Conclusion: We conclude that high FFAs level in critically ill patients is associated with features of metabolic syndrome and is not affected by short-term permissive underfeeding. The aims of this study were (1) to evaluate the clinical and nutritional correlates of high FFAs level in critically ill patients and the association with outcomes, and (2) study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. cache = ./cache/cord-003520-f3jz59pt.txt txt = ./txt/cord-003520-f3jz59pt.txt === reduce.pl bib === id = cord-001661-dj9bxhwb author = Kao, Kuo-Chin title = Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy date = 2015-05-15 pages = extension = .txt mime = text/plain words = 4381 sentences = 218 flesch = 46 summary = title: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy INTRODUCTION: Diffuse alveolar damage (DAD) is the pathological hallmark of acute respiratory distress syndrome (ARDS), however, the presence of DAD in the clinical criteria of ARDS patients by Berlin definition is little known. A pathological finding of DAD in ARDS patients is associated with hospital mortality and there are no clinical characteristics that could identify DAD patients before open lung biopsy. The following data were collected from the hospital chart of each patient and analyzed: age, sex, underlying diseases, acute physiology and chronic health evaluation (APACHE) II score on the day of ICU admission [28] , sequential organ failure assessment (SOFA) score on the day of ICU admission and the day of open lung biopsy [29] , lung injury score (LIS) [30] , PaO 2 /FiO 2 ratio, PEEP, tidal volume, diagnostic procedures before open lung biopsy (HRCT or BAL), complications related to surgery (i.e., postoperative air leak, pneumothorax, subcutaneous emphysema, bleeding, and wound infection), pathological diagnosis, hospital mortality, and therapeutic alterations. cache = ./cache/cord-001661-dj9bxhwb.txt txt = ./txt/cord-001661-dj9bxhwb.txt === reduce.pl bib === id = cord-003701-i70ztypg author = Chow, Eric J. title = Influenza virus-related critical illness: prevention, diagnosis, treatment date = 2019-06-12 pages = extension = .txt mime = text/plain words = 6869 sentences = 320 flesch = 25 summary = Based upon observational data that suggest harms, adjunctive corticosteroid treatment is currently not recommended for children or adults hospitalized with influenza, including critically ill patients, unless clinically indicated for another reason, such as treatment of asthma or COPD exacerbation, or septic shock. No completed randomized, placebo-controlled trials of antiviral treatment have been conducted in hospitalized influenza patients to establish the efficacy of oseltamivir or other NAIs. A number of observational studies have reported clinical benefit of neuraminidase inhibitors in hospitalized patients, including reduction in duration of hospitalization and risk of death, including in ICU patients [67] [68] [69] [70] [71] [72] [73] [74] . A cohort study of early versus late oseltamivir treatment reported a significant reduction in mortality and median duration of ICU hospitalization in severely ill patients with influenza A(H3N2), but not A(H1N1pdm09) or B virus infection in Greece [78] . cache = ./cache/cord-003701-i70ztypg.txt txt = ./txt/cord-003701-i70ztypg.txt === reduce.pl bib === id = cord-004310-hl7fa4af author = Matsuishi, Yujiro title = Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients date = 2020-02-10 pages = extension = .txt mime = text/plain words = 3488 sentences = 187 flesch = 48 summary = We recorded patient information, including age, sex, surgical procedure, and daily severity data (including severity of organ dysfunction and sedative/muscle relaxant dosages) during PICU stays for five days after the end of muscle relaxant usage. We found that, overall, the amount of MDZ administered was increased in DS versus controls after ending muscle relaxants and observed the reduced sedative effect of MDZ for DS patients while DEX was not different as estimated by Bayesian inference modeling. To adjust these biases, we used multivariate www.nature.com/scientificreports www.nature.com/scientificreports/ analysis with respect to these factors but we also "double checked" our results by using the demographic data propensity score for DS patients as a covariate in Bayesian inference modeling. To conclude, we conducted a retrospective study based on validated evaluative tools that indicated a need for higher doses of MDZ with higher doses of compensating sedatives for the 5-day period immediately after muscle relaxant usage following pediatric heart surgery. cache = ./cache/cord-004310-hl7fa4af.txt txt = ./txt/cord-004310-hl7fa4af.txt === reduce.pl bib === id = cord-002956-e5ihpe4i author = Chang, Ya-Chun title = Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure date = 2018-04-04 pages = extension = .txt mime = text/plain words = 4666 sentences = 272 flesch = 46 summary = title: Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure A total of 379 patients with sepsis or septic shock and acute respiratory failure requiring mechanical ventilation were admitted to the medical intensive care unit in the Kaohsiung Chang Gung Memorial Hospital from August 2013 to October 2015. We also tested and found that SOFA PaO 2 /FiO 2 subscore and GCS subscore on admission day 7 could help predict ventilator dependence on sepsis and septic shock patients with significant difference in univariate analysis ( Table 5 ). Ventilator dependence risk score, including a history of stroke and data from day 7 (thrombocytopenia, acidosis, and the higher fraction of inspired oxygen), can be applied to predict prolonged mechanical ventilation in patients who survive sepsis and septic shock. cache = ./cache/cord-002956-e5ihpe4i.txt txt = ./txt/cord-002956-e5ihpe4i.txt === reduce.pl bib === id = cord-001879-bn7h0kcw author = Papiris, Spyros A title = Survival in Idiopathic pulmonary fibrosis acute exacerbations: the non-steroid approach date = 2015-12-14 pages = extension = .txt mime = text/plain words = 4829 sentences = 224 flesch = 43 summary = In 2012 a randomized, double-blind, placebo-controlled trial based on an independent protocol reviewed by a committee appointed by the National Heart, Lung, and Blood Institute, and conducted in 25 clinical centers under the auspices of the Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet) was terminated prematurely when the interim analysis demonstrated that IPF patients treated with combination therapy with prednisone, azathioprine and N-acetylcysteine not only had no evidence of physiological or clinical benefit but presented significantly increased rate of hospitalizations, exacerbations and deaths compared to the placebo arm [5] . cache = ./cache/cord-001879-bn7h0kcw.txt txt = ./txt/cord-001879-bn7h0kcw.txt === reduce.pl bib === id = cord-004342-9uok77wb author = Lin, Chun-Yu title = Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date = 2020-02-14 pages = extension = .txt mime = text/plain words = 3003 sentences = 160 flesch = 36 summary = title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience This retrospective study aimed to clarify the shortand mid-term outcomes of elderly patients who underwent surgery to treat left-sided native valve infective endocarditis (LSNIE). The elderly group had a higher predicted mortality rate and a lower incidence of preoperative septic emboli-related complications. In this single-centre study, a comparative cohort of patients who underwent surgical treatment for active LSNIE is presented, which includes 38 elderly patients aged >65 years. Due to the increase in average life expectancy and the higher incidence of cardiovascular disease with advancing age, more elderly patients nowadays present for cardiac surgery 22 . Therefore, we suggest that a guideline-directed surgical strategy according to the presence of complications, which include embolism events, large vegetation, heart failure, or uncontrolled infection, would be beneficial to improve the mid-term outcomes of elderly patients with LSNIE. cache = ./cache/cord-004342-9uok77wb.txt txt = ./txt/cord-004342-9uok77wb.txt === reduce.pl bib === id = cord-004147-9bcq3jnm author = Fernando, Shannon M. title = New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study date = 2020-01-13 pages = extension = .txt mime = text/plain words = 4162 sentences = 213 flesch = 43 summary = title: New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study CONCLUSIONS: While NOAF was not associated with death or requiring discharge to long-term care among critically ill patients, it was associated with increased length of stay in ICU and increased total costs. We primarily sought to evaluate the association between NOAF and outcomes, resource utilization, and costs among critically ill adult patients. However, NOAF was associated with higher hospital mortality among ICU patients with suspected infection (aOR 1.21 [95% CI 1.08-1.37]), sepsis (aOR 1.24 [95% CI 1.10-1.39]), and septic shock (aOR 1.28 [95% CI 1.14-1.44]). Among patients with NOAF, factors associated with increased risk of hospital mortality included increasing age, increased MODS score, history of CHF (as identified in the Data Warehouse), and sustained AF (Additional file 5: Table S5 ). cache = ./cache/cord-004147-9bcq3jnm.txt txt = ./txt/cord-004147-9bcq3jnm.txt === reduce.pl bib === id = cord-004404-s6udpwxq author = Seifi, Najmeh title = Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies date = 2020-02-24 pages = extension = .txt mime = text/plain words = 4629 sentences = 281 flesch = 41 summary = METHODS: This is a prospective, single-center, double-blind, parallel randomized controlled trial with the aim to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in critically ill patients. DISCUSSION: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency, and length of ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism. Previous studies suggest that modulating gut microbiota by novel therapeutics, such as prebiotics, probiotics, or synbiotics, can have an effect on gastrointestinal tolerance and complications of enteral nutrition, which eventually lead to the regulation of energy intake. Considering the extreme dysbiosis in critically ill patients and related energy and macronutrients homeostasis disturbance and muscle wasting, prompted us to evaluate the effect of synbiotic supplementation on the elimination of this condition. The primary objective is to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in patients under critical care. cache = ./cache/cord-004404-s6udpwxq.txt txt = ./txt/cord-004404-s6udpwxq.txt === reduce.pl bib === id = cord-002774-tpqsjjet author = nan title = Section II: Poster Sessions date = 2017-12-01 pages = extension = .txt mime = text/plain words = 83515 sentences = 5162 flesch = 54 summary = Results: The CHIP Framework The CHIP framework aims to improve the health and wellness of the urban communities served by St. Josephs Health Centre through four intersecting pillars: • Raising Community Voices provides an infrastructure and process that supports community stakeholder input into health care service planning, decision-making, and delivery by the hospital and across the continuum of care; • Sharing Reciprocal Capacity promotes healthy communities through the sharing of our intellectual and physical capacity with our community partners; • Cultivating Integration Initiatives facilitates vertical, horizontal, and intersectoral integration initiatives in support of community-identified needs and gaps; and • Facilitating Healthy Exchange develops best practices in community integration through community-based research, and facilitates community voice in informing public policy. cache = ./cache/cord-002774-tpqsjjet.txt txt = ./txt/cord-002774-tpqsjjet.txt === reduce.pl bib === id = cord-004314-gtwtakpr author = Holmen, Heidi title = Working with patients suffering from chronic diseases can be a balancing act for health care professionals - a meta-synthesis of qualitative studies date = 2020-02-10 pages = extension = .txt mime = text/plain words = 8169 sentences = 387 flesch = 45 summary = METHOD: A systematic search of papers published between 2002 and July 2019 was conducted in the Embase, AMED, PsycINFO, MEDLINE, CINAHL, and COCHRANE databases to identify studies reporting qualitative interviews addressing HCPs' experiences working with adults with COPD, CKD or type 2 diabetes. A research group comprising 10 senior researchers (the authors), with a professional background in either nursing or physiotherapy and qualified in realist and interpretive qualitative research methods, conducted a systematic literature review of qualitative papers concerning HCPs' experiences working with patients with type 2 diabetes, CKD, and COPD. Based on our analysis of the results chapters of the included studies, three main themes were identified and developed, each addressing our overall aim to describe HCPs' experiences working with patients with long-term chronic diseases: individualizing the professional approach within the clinical encounter; managing one's emotions over time; and working to maintain professionalism (Table 4 ). cache = ./cache/cord-004314-gtwtakpr.txt txt = ./txt/cord-004314-gtwtakpr.txt === reduce.pl bib === id = cord-004096-obrq7q57 author = Benghanem, Sarah title = Brainstem dysfunction in critically ill patients date = 2020-01-06 pages = extension = .txt mime = text/plain words = 5804 sentences = 315 flesch = 36 summary = OCR: oculocephalic reflex BRASS is a clinical score that has been developed for scoring brainstem dysfunction in deeply sedated, non-brain-injured, mechanically ventilated, critically ill patients and ranges from 0 to 7 The BRASS has prognostic value, as 28-day mortality proportionally increases with the BRASS score applicable to ICU patients. The "brainstem dysfunction" hypothesis originates from our study on usefulness of neurological examination in non-brain-injured critically ill patients who required deep sedation. In deeply sedated non-brain-injured critically ill patients, the cessation of brainstem responses follows two distinct patterns. Middle latency BAEP responses and SSEP latencies were increased in 24% and 45% of deeply sedated non-brain-injured critically ill patients, respectively [34] , indicating an impairment of the brainstem conduction. Brainstem dysfunction can present with central sensory and motor deficits, cranial nerve palsies and abnormal brainstem reflexes, disorders of consciousness, respiratory failure, and dysautonomia. cache = ./cache/cord-004096-obrq7q57.txt txt = ./txt/cord-004096-obrq7q57.txt === reduce.pl bib === id = cord-002757-upwe0cpj author = Sullivan, Kathleen E. title = Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies date = 2017-08-07 pages = extension = .txt mime = text/plain words = 24212 sentences = 1364 flesch = 40 summary = The first section addresses general considerations, the second section profiles specific infections organized according to mechanism of transmission, and the third section focuses on unique phenotypes and unique susceptibilities in patients with PIDDs. This review does not address most parasitic diseases. In developing countries where polio is still endemic and oral polio vaccine is essential for eradicating the disease, it is of utmost importance that all PIDD patients and family members should not receive live oral polio (OPV) because of the reported prolonged excretion of the virus for months and even years [24] . As for host factors, although severe and fatal cases have been described in healthy immunocompetent hosts [129, 130] , there is evidence to suggest that children under the age of 10 [130] and immunocompromised hosts either secondary to hematologic malignancies, immunosuppressant treatment for organ transplantation, or HIV infection are at a greater risk to develop more severe disease with higher case fatality rates [131, 132] . cache = ./cache/cord-002757-upwe0cpj.txt txt = ./txt/cord-002757-upwe0cpj.txt === reduce.pl bib === id = cord-003291-zuqx6ksy author = Tang, Pingping title = Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review date = 2018-11-03 pages = extension = .txt mime = text/plain words = 3054 sentences = 191 flesch = 49 summary = title: Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review METHODS: A retrospective cohort study was conducted with 12 patients who were diagnosed with severe pneumonia complicating pregnancy at Peking Union Medical College Hospital between January 2010 and June 2017. High incidences of adverse fetal outcomes were observed; thus, termination of the pregnancy is recommended for patients in their third trimester when respiratory function deteriorates progressively. Several physiological and immunological changes that are experienced during pregnancy, such as altered T lymphocyte immunity, increased oxygen consumption, decreased functional residual capacity, decreased chest compliance, and increased risk of aspiration, may predispose pregnant women to a more severe course of pneumonia, which may result in greater maternal and fetal morbidity and mortality [1, 4] . The patients' clinical data including symptoms at presentation, laboratory tests, and treatment strategies were reviewed carefully to screen for severe pneumonia. cache = ./cache/cord-003291-zuqx6ksy.txt txt = ./txt/cord-003291-zuqx6ksy.txt === reduce.pl bib === id = cord-001154-7k59ogn0 author = Memoli, Matthew J. title = The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts date = 2013-11-01 pages = extension = .txt mime = text/plain words = 3912 sentences = 200 flesch = 31 summary = Evaluation of viral shedding, nasal and serum cytokines, clinical illness, and clinical outcomes were performed to compare severely immunocompromised individuals to nonimmunocompromised individuals with influenza infection. Immunocompromised patients with influenza had more severe disease/complications, longer viral shedding, and more antiviral resistance while demonstrating less clinical symptoms and signs on clinical assessment. Careful examination of symptoms and signs of infection, virological measurements, immunological studies, and clinical parameters were performed to investigate the natural pathogenesis of influenza in this group of severely immunocompromised hosts. The comparison of these individuals with nonimmunocompromised individuals during influenza infection demonstrated that the immunocompromised patients are at risk of more severe or complicated disease, which may be difficult to prevent with current vaccines and treat with current antivirals. cache = ./cache/cord-001154-7k59ogn0.txt txt = ./txt/cord-001154-7k59ogn0.txt === reduce.pl bib === id = cord-003798-nki2sasr author = Vidaur, Loreto title = Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis date = 2019-07-24 pages = extension = .txt mime = text/plain words = 3501 sentences = 195 flesch = 41 summary = BACKGROUND: Information on the clinical, epidemiological and molecular characterization of human metapneumovirus in critically ill adult patients with severe community-acquired pneumonia (CAP) and the role of biomarkers identifying bacterial coinfection is scarce. METHODS: This is a retrospective epidemiological study of adult patients with hMPV severe CAP admitted to ICU during a ten-year period with admission PSI score ≥ 3. The main objective of this study was to describe the clinical and epidemiological characteristics of adults with severe pneumonia caused by hMPV who required intensive care unit (ICU) admission, over a long period of time. Interestingly, three patients (10.7%) were young adult patients without comorbidities and without bacterial coinfection that developed ARDS pointing out a main role of hMPV in the etiology of severe respiratory infections requiring mechanical ventilation. Main characteristics of immunosuppressed adult patients admitted to the Intensive Care Unit due to a severe community-acquired pneumonia associated with human metapneumovirus infection (Guipuzcoa, Basque Country, Spain, 2007-2017). cache = ./cache/cord-003798-nki2sasr.txt txt = ./txt/cord-003798-nki2sasr.txt === reduce.pl bib === id = cord-001078-5m29nugu author = Chen, Xiaorong title = Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study date = 2013-09-17 pages = extension = .txt mime = text/plain words = 3930 sentences = 200 flesch = 47 summary = title: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study OBJECTIVE: The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection. Factors analyzed for possible correlation with clinical features and treatment outcomes in patients included 1) baseline characteristics of patients, such as age, sex, occupation, underlying conditions, exposure to poultry and/or wild birds in the past seven days, date of symptom onset and hospital admission, date of specimen collection, and date of positive diagnosis; 2) results from laboratory tests and imaging examinations; 3) treatment regimen including basic supporting therapy, antibiotic therapy, antiviral therapy, traditional Chinese medicine (TCM) therapy, and other therapies if applicable; and 4) current condition of patients including the length of stay in the hospital. cache = ./cache/cord-001078-5m29nugu.txt txt = ./txt/cord-001078-5m29nugu.txt === reduce.pl bib === id = cord-000161-hxjxczyr author = Rello, Jordi title = Clinical review: Primary influenza viral pneumonia date = 2009-12-21 pages = extension = .txt mime = text/plain words = 3652 sentences = 195 flesch = 35 summary = Primary influenza pneumonia has a high mortality rate during pandemics, not only in immunocompromised individuals and patients with underlying comorbid conditions, but also in young healthy adults. Pneumonia and the acute respiratory distress syndrome (ARDS) account for the majority of severe morbidity and mortality that accompany pandemic influenza infection [14] . A recent analysis of lung specimens from 77 fatal cases of pandemic H1N1v 2009 infection found a prevalence of concurrent bacterial pneumonia in 29% of these patients [31] . A recent World Health Organization treatment guideline for pharmacological management of 2009 pandemic H1N1v influenza A recommends the consideration of higher doses of oseltamivir (150 mg twice a day) and longer duration of treatment for patients with severe influenza pneumonia or clinical deterioration [44] . The rapid progression from initial typical influenza symptoms to extensive pulmonary involvement, with acute lung injury, can occur both in patients with underlying respiratory or cardiac morbidities and in young healthy adults, especially if obese or pregnant. cache = ./cache/cord-000161-hxjxczyr.txt txt = ./txt/cord-000161-hxjxczyr.txt === reduce.pl bib === id = cord-001493-3yu2di1g author = Fujishima, Seitaro title = Pathophysiology and biomarkers of acute respiratory distress syndrome date = 2014-05-07 pages = extension = .txt mime = text/plain words = 3096 sentences = 159 flesch = 36 summary = Acute respiratory distress syndrome (ARDS) is defined as an acute-onset, progressive, hypoxic condition with radiographic bilateral lung infiltration, which develops after several diseases or injuries, and is not derived from hydrostatic pulmonary edema. In parallel with progress in understanding the pathophysiology of ARDS, various humoral factors induced by inflammation and molecules derived from activated cells or injured tissues have been shown as potential biomarkers that may be applied in clinical practice. Numerous proinflammatory cytokines play major roles in acute inflammation and the development of inflammatory lung diseases, including ARDS. Increased levels of soluble receptor for advanced glycation end products (sRAGE) and high mobility group box 1 (HMGB1) are associated with death in patients with acute respiratory distress syndrome Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients Acute Respiratory Distress Syndrome Network: Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury cache = ./cache/cord-001493-3yu2di1g.txt txt = ./txt/cord-001493-3yu2di1g.txt === reduce.pl bib === id = cord-000904-g6ffaer1 author = Ni, Hong title = Sorafenib Combined with Cryoablation to Treat Unresectable Hepatocellular Carcinoma date = 2011-09-17 pages = extension = .txt mime = text/plain words = 3449 sentences = 186 flesch = 46 summary = OBJECTIVE: To evaluate the efficacy and tolerability of sorafenib combined with cryoablation in treating unresectable hepatocellular carcinoma (HCC). METHODS: Patients with unresectable advanced HCC received cryoablation and sorafenib at a dose of 400 mg twice daily in 4-week cycles on the same day of the cryoablation. CONCLUSION: Cryoablation combined with sorafenib demonstrates good efficacy and acceptable tolerability in treating unresectable advanced HCC patients. Among patients with advanced disease who do not qualify for surgical or liver transplantation therapies, the only non-chemotherapeutic treatment that has been shown to increase survival is sorafenib [6] . In this paper, we report the results of our prospective study conducted to evaluate the efficacy and acceptable tolerability of sorafenib as adjuvant treatment after cryoablation in the treatment of unresectable HCC. However, all other patients and tumor characteristics, including age, sex, ECOG performance status, Child-Pugh class, ongoing antiviral therapy, BCLC stage, and prior systemic treatment had no effect on clinical benefits. cache = ./cache/cord-000904-g6ffaer1.txt txt = ./txt/cord-000904-g6ffaer1.txt === reduce.pl bib === id = cord-000891-5r2in1gw author = Giannella, Maddalena title = Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? date = 2012-06-14 pages = extension = .txt mime = text/plain words = 4115 sentences = 233 flesch = 44 summary = Suspected and unsuspected cases were compared, and significant differences were found for age (53 versus 69 median years), severe respiratory failure (68.8% versus 20%), surgery (6.3% versus 60%), median days of ICU stay before diagnosis (1 versus 4), nosocomial infection (18.8% versus 66.7%), cough (93.8% versus 53.3%), localized infiltrate on chest radiograph (6.3% versus 40%), median days to antiviral treatment (2 versus 9), pneumonia (93.8% versus 53.3%), and acute respiratory distress syndrome (75% versus 26.7%). The variables recorded were age, sex, classification of the severity of underlying conditions according to the Charlson comorbidity index [6] , type of ICU, date and cause of ICU admission, APACHE II score [7] on admission to the ICU, date of onset of influenza symptoms, clinical manifestations and radiologic findings at diagnosis, date of TA sample collection, other samples tested for influenza and result, date of initiation of antiviral treatment, complications (septic shock, acute respiratory distress syndrome (ARDS)), outcome including mortality within 30 days after influenza diagnosis, and length of ICU and hospital stay. cache = ./cache/cord-000891-5r2in1gw.txt txt = ./txt/cord-000891-5r2in1gw.txt === reduce.pl bib === id = cord-004636-t6qldq3s author = Saugel, Bernd title = Journal of Clinical Monitoring and Computing end of year summary 2019: hemodynamic monitoring and management date = 2020-03-14 pages = extension = .txt mime = text/plain words = 10306 sentences = 479 flesch = 42 summary = In the original data set, 8.8% of the intraoperative MAP measurements were > 100 mmHg and 4.3% were < 55 mmHg. After automated and manual correction 7.3% (automated) or 7.3% (manual) of MAP measurements were > 100 mmHg and 2.0% (automated) or 2.1% (manual) were < 55 mmHg. The authors discuss potential limitations of the proposed algorithm during episodes with high blood pressure variability as it may be difficult to distinguish real variation from artifacts. The authors included 2273 cases with intra-arterial blood pressure measurements and analyzed changes in intraoperative SAP in four different age groups. In a pilot study, Pybus [38] investigated the feasibility of performing real-time spectral analyses of the respiratory and arterial pressure waveform in 60 cardiac surgical patients and assessed the clinical utility of this technique to predict fluid responsiveness. cache = ./cache/cord-004636-t6qldq3s.txt txt = ./txt/cord-004636-t6qldq3s.txt === reduce.pl bib === id = cord-003219-iryb3v0z author = Kao, Kuo-Chin title = Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning date = 2018-09-24 pages = extension = .txt mime = text/plain words = 4357 sentences = 214 flesch = 44 summary = title: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning CONCLUSIONS: In the present study, in evaluating the effect of prone positioning in patients with influenza pneumonia-related ARDS, pneumonia severity index, renal replacement therapy and increase in dynamic driving pressure were associated with 60-day mortality in patients with influenza pneumonia-related ARDS receiving prone positioning. After multivariate Cox regression analysis, PSI, renal replacement therapy and increased dynamic driving pressure were associated with 60-day mortality in patients with influenza pneumonia-related ARDS receiving prone positioning. The present study in influenza pneumonia-related ARDS patients receiving prone positioning also found that increased dynamic driving pressure (hazard ratio 1.372, 95% confidence interval 1.095-1.718; p = 0.006) was identified as After multivariate Cox regression analysis, it was found that PSI, renal replacement therapy and increased dynamic driving pressure were associated with 60-day mortality in patients with influenza pneumoniarelated ARDS receiving prone positioning. cache = ./cache/cord-003219-iryb3v0z.txt txt = ./txt/cord-003219-iryb3v0z.txt === reduce.pl bib === id = cord-000268-480d3yfv author = Porfyridis, Ilias title = Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date = 2010-09-29 pages = extension = .txt mime = text/plain words = 4276 sentences = 222 flesch = 45 summary = title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study The aim of the present study was to define whether expression of TREM-1 on cell membranes of neutrophils (nTREM-1), of monocytes (mTREM-1) and serum sTREM-1 may help in the diagnosis of acute bacterial infections for patients admitted with a new pulmonary infiltrate or pleural effusion. In conclusion, the presented results indicate that serum sTREM-1 and expression of TREM-1 on neutrophils and monocytes may serve as markers of CAP in patients with pulmonary infiltrates. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis Prognosis of community acquired pneumonia(CAP): value of triggering receptor expressed on myeloid cells-1 (TREM-1) and other mediators of the inflammatory response Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU cache = ./cache/cord-000268-480d3yfv.txt txt = ./txt/cord-000268-480d3yfv.txt === reduce.pl bib === id = cord-002145-yq7iwp42 author = Ibrahim, Ahmed title = Clinical profile and outcome of patients with acute kidney injury requiring dialysis—an experience from a haemodialysis unit in a developing country date = 2016-07-22 pages = extension = .txt mime = text/plain words = 2712 sentences = 139 flesch = 52 summary = title: Clinical profile and outcome of patients with acute kidney injury requiring dialysis—an experience from a haemodialysis unit in a developing country This study was conducted to describe the clinical profile and outcome of adult Acute Kidney Injury (AKI) patients treated with intermittent haemodialysis at the dialysis center of SPHMMC. The aim of this study is to describe the clinical profile and outcome of all adult AKI patients treated with intermittent haemodialysis at the unit in the first 18 months since its establishment. The medical record numbers of all patients dialyzed during the study period were identified from the dialysis unit log book and the clinical records retrieved from the hospital record office. Though difficult to accurately diagnose in our setup due to lack of availability of renal biopsy, AGN (diagnosed through clinical means) was found to be a common cause of AKI requiring dialysis. cache = ./cache/cord-002145-yq7iwp42.txt txt = ./txt/cord-002145-yq7iwp42.txt === reduce.pl bib === id = cord-003686-1pfk4qve author = Kaneko, Naoe title = The role of interleukin-1 in general pathology date = 2019-06-06 pages = extension = .txt mime = text/plain words = 9464 sentences = 514 flesch = 38 summary = The majority of NOD-like receptors such as NLRP1, NLRP3, NLRC4, NLRP6, and NLRP12 can interact with apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) and caspase-1, and the resulting complex is a sensor of cell injury called "inflammasome", an interleukin (IL)-1β-processing platform that plays a crucial role in IL-1β maturation and secretion from cells. NLRP3 inflammasomes have also been reported to be involved in low-grade subclinical inflammation induced by chronic exposure to high levels of free fatty acids and glucose, leading to increased apoptosis and impaired insulin secretion of β-cells in obese type 2 diabetes mellitus (T2D) patients [102] [103] [104] . Canakinumab and anakinra were also effective for patients with Schnitzler syndrome, an adult-onset autoinflammatory disease characterized by focal urticaria and systemic inflammation including fever with bone and muscle pain, in the first placebo-controlled study, and several clinical trials are currently ongoing [186] [187] [188] [189] . cache = ./cache/cord-003686-1pfk4qve.txt txt = ./txt/cord-003686-1pfk4qve.txt === reduce.pl bib === id = cord-004450-daxz9yhp author = Haeberle, Helene title = Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study date = 2020-03-04 pages = extension = .txt mime = text/plain words = 5848 sentences = 383 flesch = 48 summary = Several preclinical studies have revealed a beneficial effect of iloprost on the control of pulmonary inflammation, and in a small number of patients with ARDS, iloprost treatment resulted in improved oxygenation. For safety reasons, after treatment of 100 patients (day 28 after last dose investigational medicinal product [IMP] Patient 100) within the study, an interim analysis for an increased risk for pulmonary hemorrhage ≥ grade III according to Common Terminology (Toxicity) Criteria for Adverse Events (CTCAE) Version 5.0 in the treatment (iloprost) arm will be performed and the results discussed with the Data and Safety Monitoring Board (DSMB). When possible, however, the patient or his legal representative is to be informed both in writing and verbally by the investigator before any study-specific procedure is Iloprost or NaCl 0.9% (control) X X X X X Clinical assessment including outcome X X X X X X X X X Laboratory testing X X X X X X X X Adverse/serious adverse event monitoring X X X X X X X Plasma biomarkers X X X X X X Barthel Index X X X X SOFA score X X X X X X X X Health-related questionnaire X VES X performed. cache = ./cache/cord-004450-daxz9yhp.txt txt = ./txt/cord-004450-daxz9yhp.txt === reduce.pl bib === id = cord-005482-v5iayczy author = nan title = Publication Only date = 2016-03-21 pages = extension = .txt mime = text/plain words = 27400 sentences = 1715 flesch = 54 summary = Material (or patients) and methods: Case Report 23-year-old male patient who underwent allogeneic hematopoietic stem cell tranplantation sixteen months ago, admitted to bone marrow transplantation clinic for shortness of breath. Material (or patients) and methods: Data sets of 436 consecutive patients who underwent allogeneic HSCT at a single center (University of Rostock) from 1998 to 10/2015 were analysed regarding their early mortality rates (d+30, d+60 Introduction: Mobilization and collection of CD34-positive stem cells for subsequent high-dose chemotherapy constitutes a standard approach in myeloma patients achieving a good remission after induction chemotherapy. Outcomes of high grade gastrointestinal gvhd post-hsct in children Material (or patients) and methods: This is a retrospective analysis of 28 pediatric patients presented with a clinical diagnosis of stage 3 and 4 acute GVHD of the GIS who were selected from allogeneic hematopoetic stem cell transplantation (HSCT) performed. cache = ./cache/cord-005482-v5iayczy.txt txt = ./txt/cord-005482-v5iayczy.txt === reduce.pl bib === id = cord-003198-1kw5v6rm author = Vuillard, Constance title = Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study date = 2018-09-11 pages = extension = .txt mime = text/plain words = 4851 sentences = 242 flesch = 42 summary = The following data were collected on a standardized anonymized case record form: demographic characteristics (age, gender), severity scores upon ICU admission (Sequential Organ Failure Assessment [23] and Simplified Acute Physiology Score II [24] ), main comorbidities, delay between first respiratory sign and ICU admission, clinical examination (respiratory and extra-respiratory manifestations) and laboratory findings at the time of ICU admission (blood leukocytes and platelets counts, serum procalcitonine, C-reactive protein, creatine kinase and creatinine levels, PaO 2 /FiO 2 with FiO 2 calculated according to the following formula [25, 26] : FiO 2 = oxygen flow in liter per minute × 0.04 + 0.21 when standard oxygen was used), radiological findings on chest X-ray and CT scan, cytological and bacteriological analyses of broncho-alveolar lavage (BAL) fluid, type of positive autoantibodies (Jo-1, PL7, PL12, OJ, EJ, KS, Zo, YRS/Tyr/ Ha or aMDA-5), immunosuppressive treatments received (corticosteroids, cyclophosphamide, rituximab, basiliximab, tacrolimus, cyclosporine, methotrexate, intravenous immunoglobulins or plasma exchange), organ supports in the ICU (invasive mechanical ventilation, extra-corporeal membrane oxygenation (ECMO), renal replacement therapy, vasopressors), ICU and hospital length of stay, ICU and hospital mortality. cache = ./cache/cord-003198-1kw5v6rm.txt txt = ./txt/cord-003198-1kw5v6rm.txt === reduce.pl bib === id = cord-001293-dfaxj3bv author = Cavaillon, Jean-Marc title = Is boosting the immune system in sepsis appropriate? date = 2014-03-24 pages = extension = .txt mime = text/plain words = 6238 sentences = 315 flesch = 33 summary = In response to the failure of therapies aiming to target either the up-stream microbial activators or the effector molecules of the inflammatory cascade, a new concept has emerged of boosting the immune system to counter immunosuppression that develops in patients who survive the initial, hyperinflammatory period of sepsis [1] . One can conjecture that systemic treatment with IL-7 may act in undesired places, as illustrated by the following: IL-7 worsens graft-versus-host-induced tissue inflammation [81] ; favors inflammation in colitis [82] , contributes to arthritis severity [83] ; upregulates chemokines, IFNγ, macrophage recruitment, and lung inflammation [84] ; and, finally, increases production of inflammatory cytokines by monocytes and T cells [85] . Not only are PD-1-deficient mice markedly protected from the lethality of sepsis, accompanied by a decreased bacterial burden and suppressed inflammatory cytokine response [98] , but also blockade of PD-1 or PD-L1 improves survival in a murine model of sepsis, reverses immune dysfunction, inhibits lymphocyte apoptosis, and attenuates organ dysfunction [99] [100] [101] . cache = ./cache/cord-001293-dfaxj3bv.txt txt = ./txt/cord-001293-dfaxj3bv.txt === reduce.pl bib === id = cord-004532-flo9139j author = Andrews, Peter title = Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis date = 2004-12-18 pages = extension = .txt mime = text/plain words = 9246 sentences = 474 flesch = 44 summary = The authors concluded that their findings are important for trial design because of the observed differences in outcome, and proposed the use of standardized ventilator settings for patient enrollment. As indicated by Yu and Singh [46] , "over 300 studies have been published in peer-review journals in the past 8 years dealing with management of ventilator-associated pneumonia (VAP)." However, no consensus exists to date on the best way for identifying patients with true lung infection, for selecting early appropriate antimicrobial therapy, or for avoiding unnecessary use of antibiotics. [52] designed a study in 108 patients with 171 VAPs to assess the impact on the duration of MV and the use of antibiotic treatment of the results of a diagnostic technique: the percentage of infected cells in liquid obtained with BAL, i.e., the value of direct examination. cache = ./cache/cord-004532-flo9139j.txt txt = ./txt/cord-004532-flo9139j.txt === reduce.pl bib === id = cord-005496-cnwg4dnn author = Gutierrez, Guillermo title = Artificial Intelligence in the Intensive Care Unit date = 2020-03-24 pages = extension = .txt mime = text/plain words = 5011 sentences = 235 flesch = 40 summary = Whereas humans develop generalized concepts on the basis of just a few examples, training a machine learning algorithm requires large quantities of data. Other studies have been published describing the use of machine learning models in generating patient-specific risk scores for pulmonary emboli [30] , risk stratification of ARDS [31] , prediction of acute kidney injury in severely burned patients [32] and in general ICU populations [33] , prediction of volume responsiveness after fluid administration [34] and identification of patients likely to develop complicated Clostridium difficile infection [35] . evaluated several types of machine learning algorithms, including random forest, naïve Bayes, and AdaBoost on data recorded from 62 mechanically ventilated patients with or at risk of ARDS. Machine learning algorithms have been used to analyze data stored in electronic medical records to predict ICU mortality and length of stay. cache = ./cache/cord-005496-cnwg4dnn.txt txt = ./txt/cord-005496-cnwg4dnn.txt === reduce.pl bib === id = cord-005425-0hxow3sj author = Lekakis, L title = Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies date = 2006-08-07 pages = extension = .txt mime = text/plain words = 2757 sentences = 161 flesch = 55 summary = title: Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies In order to overcome this barrier, we investigated a strategy by which patients without higher priority donors were to be transplanted with an unrelated CB unit that should contain at least 2  10 7 total nucleated cells (TNCs)/kg of recipient weight. Here, we report the results of a phase II trial that enrolled heavily pretreated patients with high-risk hematologic malignancies that was prematurely interrupted owing to high rates of engraftment failure and excessive mortality. Transplants of umbilical cord blood or bone marrow from unrelated donors in adults with Acute Leukemia Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia Hematopoietic engraftment and survival in adults recipients of umbilical-cord blood from unrelated donors Successful engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with advanced hematological diseases cache = ./cache/cord-005425-0hxow3sj.txt txt = ./txt/cord-005425-0hxow3sj.txt === reduce.pl bib === id = cord-003011-vclnb0eh author = de Almeida, Carlos Podalirio Borges title = Predictors of In-Hospital Mortality among Patients with Pulmonary Tuberculosis: A Systematic Review and Meta-analysis date = 2018-05-08 pages = extension = .txt mime = text/plain words = 2833 sentences = 173 flesch = 45 summary = title: Predictors of In-Hospital Mortality among Patients with Pulmonary Tuberculosis: A Systematic Review and Meta-analysis The aim of this systematic review and meta-analysis is to identify predictors of in-hospital mortality among patients with PTB. Methods: We searched MEDLINE, EMBASE, and Global Health, for cohort and case-control studies that reported risk factors for in-hospital mortality in PTB. We therefore conducted a systematic review and meta-analysis to establish predictors of in-hospital mortality among patients with pulmonary TB. Eligible trials met the following criteria 1 : cohort or case-control design 2 ; explored risk factors for in-hospital mortality among patients with pulmonary TB in an adjusted analysis. This systematic review and meta-analysis is expected to serve as a basis for evidence to reduce in-hospital mortality in TB patients, and as a guide for future research based on identified knowledge gaps. Predictors of in-hospital mortality among patients with pulmonary tuberculosis: a protocol of systematic review and meta-analysis of observational studies cache = ./cache/cord-003011-vclnb0eh.txt txt = ./txt/cord-003011-vclnb0eh.txt === reduce.pl bib === id = cord-004646-zhessjqh author = Bawazeer, Mohammed title = Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial date = 2020-03-20 pages = extension = .txt mime = text/plain words = 7841 sentences = 381 flesch = 42 summary = title: Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial The 2018 Pain, Agitation/sedation, Delirium, Immobility, and Sleep disruption guideline suggested low-dose ketamine infusion as an adjunct to opioid therapy to reduce opioid requirements in post-surgical patients in the intensive care unit (ICU). Therefore, we propose a prospective, randomized, active controlled, open-label, pilot, feasibility study to assess the effect and safety of Analgo-sedative ad-juncT keTAmine Infusion iN Mechanically vENTilated ICU patients (the ATTAINMENT trial) compared to standard of care alone. Physician decline after randomization Ketamine will be discontinued Subject will be included in the data analysis a In cases of death (either within the first 48 h, until ICU or hospital discharge, or 28 days after randomization, whichever comes first), detailed documentation will be carried out in the medical record for the cause of death, group allocation, and relation to study protocol allocation and initiation of the trial intervention. cache = ./cache/cord-004646-zhessjqh.txt txt = ./txt/cord-004646-zhessjqh.txt === reduce.pl bib === id = cord-003446-yp5d29fk author = Edwards, Michael title = An Uncommon Cause of Spontaneous Pneumomediastinum and Subcutaneous Emphysema date = 2017-02-03 pages = extension = .txt mime = text/plain words = 1284 sentences = 83 flesch = 42 summary = A 79-year-old gentleman presented with spontaneous pneumomediastinum and subcutaneous emphysema with pneumonia but no pre-existing lung disease. After 4 days of intravenous antibiotics, the patient developed considerable subcutaneous emphysema and pneumomediastinum. Pneumomediastinum presents most commonly with chest pain, shortness of breath, and subcutaneous emphysema. Treatment of pneumomediastinum is typically conservative, and although options may be limited, aggressive management of any causative factor may be essential in selected cases. A case of spontaneous pneumomediastinum and subcutaneous emphysema in a 79-year-old gentleman with pneumonia but no pre-existing lung disease is presented. A 79-year-old gentleman presented with a 4-day history of increased shortness of breath, pleuritic chest pain, fevers, and non-productive cough. A repeat chest x-ray showed extensive subcutaneous emphysema and led to a diagnosis of suspected pneumomediastinum. Pneumomediastinum presents most commonly with chest pain, shortness of breath, and subcutaneous emphysema but rhinolalia, cough, neck pain, emesis, and dysphagia are also possible [4] . cache = ./cache/cord-003446-yp5d29fk.txt txt = ./txt/cord-003446-yp5d29fk.txt === reduce.pl bib === id = cord-002853-vj8t28hn author = Joffe, Michael title = Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient date = 2018-01-27 pages = extension = .txt mime = text/plain words = 2128 sentences = 112 flesch = 41 summary = BACKGROUND: We report a fatal case of disseminated adenovirus infection in a non-transplant haematology adult patient with chronic lymphocytic leukaemia who had completed combination chemoimmunotherapy a few months before developing respiratory symptoms. CASE PRESENTATION: This case started with an initial bacterial chest infection that responded to treatment, followed by an adenovirus pneumonitis that disseminated to his blood a week later with levels of up to 92 million adenovirus DNA copies/ml. We report here a case of adenovirus pneumonitis which led to a fatal disseminated adenovirus infection in an adult patient with chronic lymphocytic leukaemia (CLL) on chemotherapy. This patient's chemotherapy regimen included fludarabine which has severe lymphopaenia as a recognised adverse effect, and which has been present in treatment regimens where various other viral reactivations have occurred, including hepatitis B [10] [11] [12] , BK virus [13] , herpes simplex and Epstein-Barr viruses [14] , cytomegalovirus [15] , as well as adenovirus [16] . cache = ./cache/cord-002853-vj8t28hn.txt txt = ./txt/cord-002853-vj8t28hn.txt === reduce.pl bib === id = cord-001536-ta1i0ata author = Nair, Girish B title = Year in review 2013: critical care - respiratory infections date = 2014-10-29 pages = extension = .txt mime = text/plain words = 8891 sentences = 335 flesch = 37 summary = New studies have suggested strategies to identify patients at risk for resistant pathogen infection and therapies that optimize efficacy, without the overuse of broad-spectrum therapy in patients with healthcare-associated pneumonia. Infections, mostly nosocomial, are a major cause of mortality in hospitalized patients related to an increased risk of infection with multi-drug resistant (MDR) pathogens and the widespread use of indiscriminate broad-spectrum antibiotics. In a study including 519 patients with CAP and 419 with HCAP, the authors compared the performance of Pneumonia Severity Index (PSI) and CURB-65 risk scores for predicting 30-day mortality [20] . Maruyama and colleagues [23] , in a prospective study of 425 patients (CAP = 124, HCAP = 321), applied a therapeutic algorithm based on the presence of MDR risk factors (immunosuppression, hospitalization within the last 90 days, poor functional status indicated by a Barthel Index score <50, and antibiotic therapy within the past 6 months) and severity of illness (need for ICU admission or requiring MV) to determine its impact on outcomes. cache = ./cache/cord-001536-ta1i0ata.txt txt = ./txt/cord-001536-ta1i0ata.txt === reduce.pl bib === id = cord-000843-e1bn79ui author = nan title = ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme date = 2011-03-01 pages = extension = .txt mime = text/plain words = 91224 sentences = 4805 flesch = 41 summary = The role of radiology includes (a) characterisation of sonographically indeterminate adnexal masses, (b) staging as guidance for surgery and treatment planning (including identification of sites of non optimal resectabilty) in suspected ovarian cancer, (c) assessment of recurrent disease, and (d) in selected cases image-guided biopsy. The association of multiple markers of structural and functional imaging (MRI and PET) and the use of advanced computational analysis techniques will allow better management of AD but it needs a broader validation and know the most efficient combination of biomarkers at each stage of the disease, including the preclinical period. Although the basic techniques for DCE-CT have been available for decades, more recently a range of technological advances have contributed to the greater applicability of perfusion CT in the clinical environment including wider CT detectors, shorter gantry rotation times, 'table-toggling', radiation dose reduction and software corrections for image mis-registration due to respiratory or other patient motion. cache = ./cache/cord-000843-e1bn79ui.txt txt = ./txt/cord-000843-e1bn79ui.txt === reduce.pl bib === id = cord-003376-2qi4aibx author = van de Groep, Kirsten title = Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study date = 2018-12-18 pages = extension = .txt mime = text/plain words = 3889 sentences = 191 flesch = 42 summary = title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study Cytomegalovirus (CMV) reactivation is observed in 14-41% of intensive care unit (ICU) patients without known prior immune deficiency [1] [2] [3] and is associated with increased morbidity and mortality [4] [5] [6] . Therefore, this longitudinal study aimed to investigate whether the temporal course of seven host response biomarkers, including both pro-and anti-inflammatory cytokines, in previously immunocompetent ICU patients with sepsis differs between patients with and without CMV reactivation. Time trends of various markers within patients were described by symmetric percentage differences relative to their levels 2 days prior to CMV viremia onset (Fig. 2 for primary comparison, Additional file 1: Figure S1 for secondary comparison). We performed an explorative study to compare time trends of host response biomarkers in patients with reactivation that were matched to non-reactivating control patients who were either seropositive or seronegative for CMV. cache = ./cache/cord-003376-2qi4aibx.txt txt = ./txt/cord-003376-2qi4aibx.txt === reduce.pl bib === id = cord-004464-nml9kqiu author = Lhommet, Claire title = Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation? date = 2020-03-06 pages = extension = .txt mime = text/plain words = 4443 sentences = 235 flesch = 43 summary = title: Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation? Whether the etiology of CAP is viral or bacterial should be determined based on the patient interview, clinical symptoms and signs, biological findings and radiological data from the very first hours of the patient's presentation (a time when microbiological findings are typically not yet available). The aim of our study was to evaluate and compare the abilities of experienced physicians and a data-driven approach to answer this simple question within the first hours of a patient's admission to the ICU for CAP: is it a viral or a bacterial pneumonia? Step 2: clinician and data-driven predictions of microbial etiology Clinicians and a mathematical algorithm were tasked with predicting the microbial etiology of pneumonia cases based on all clinical (43 items), and biological or radiological (17 items) information available in the first 3-h period after admission except for any microbiological findings (Supplementary Table 1 ). cache = ./cache/cord-004464-nml9kqiu.txt txt = ./txt/cord-004464-nml9kqiu.txt === reduce.pl bib === id = cord-003832-q1422ydi author = Koyama, Kansuke title = Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors date = 2019-08-19 pages = extension = .txt mime = text/plain words = 4659 sentences = 242 flesch = 40 summary = title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors This study aimed to investigate the biomarker profiles of coagulopathy and alveolar epithelial injury in two subtypes of ARDS: patients with direct common risk factors (dARDS) and those with idiopathic or immune-related diseases (iARDS), which are classified as "ARDS without common risk factors" based on the Berlin definition. Although no risk factors or causes are identified in this subgroup of ARDS, recent studies have shown that many patients with idiopathic interstitial pneumonia have clinical features that suggest an underlying immune process, indicating that the pathobiology of idiopathic and immunerelated diseases may partially overlap [9, 10] . The aim of this study was to examine the profiles of the plasma biomarkers that reflect coagulopathy and alveolar epithelial injury in patients with idiopathic/immune-related ARDS (iARDS) and in those with common direct risk factors (dARDS). cache = ./cache/cord-003832-q1422ydi.txt txt = ./txt/cord-003832-q1422ydi.txt === reduce.pl bib === id = cord-004263-m1ujhhsc author = Koekkoek, W. A. C. title = The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study date = 2020-02-03 pages = extension = .txt mime = text/plain words = 3155 sentences = 178 flesch = 44 summary = title: The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study METHODS: We studied a cohort of adult critically ill patients requiring invasive mechanical ventilation and treatment with continuous infusion of cisatracurium for at least 12 h. CONCLUSIONS: Our data suggest that continuous infusion of cisatracurium in mechanically ventilated ICU patients is associated with a significant reduction in EE, although the magnitude of the effect is small. Our data suggest that continuous infusion of cisatracurium in mechanically ventilated ICU patients is associated with a significant reduction in EE as estimated by the VCO 2 method, although the magnitude of the effect is small. Validation of carbon dioxide production (VCO2) as a tool to calculate resting energy expenditure (REE) in mechanically ventilated critically ill patients: a retrospective observational study cache = ./cache/cord-004263-m1ujhhsc.txt txt = ./txt/cord-004263-m1ujhhsc.txt === reduce.pl bib === id = cord-002626-jzwwses4 author = Kaul, Karen L. title = The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care date = 2017-07-16 pages = extension = .txt mime = text/plain words = 14822 sentences = 754 flesch = 40 summary = Clinical laboratories have thus had to develop new assays or modified the existing FDA-approved ones to detect high-risk HPV genotypes in head and neck cancer specimens. The vast majority of reporting laboratories utilized LDPs. 57 KRAS and RAS family gene mutation analysis is also critical in the management of patients with non-small-cell lung cancer (NSCLC) and other tumors, 58 for which FDA approval of kits has not occurred; LDPs or off-label use of kits is required. 74, 75 The FDA approval of anti-EGFR therapies based on clinical trial outcomes data resulted in the need for clinical laboratories to test tumor tissue for the EGFR-sensitizing mutations in order for patients to be eligible for treatment. During those ground-breaking first 15 years of the targeted cancer therapy era, if the laboratory community had been prohibited from providing high-quality, standardized LDP-based testing under existing CLIA guidelines, the negative consequences to patient care in the past and the future would have been substantial. cache = ./cache/cord-002626-jzwwses4.txt txt = ./txt/cord-002626-jzwwses4.txt === reduce.pl bib === === reduce.pl bib === id = cord-003615-vpzzsdld author = Thompson, Kelly B. title = Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies date = 2019-04-24 pages = extension = .txt mime = text/plain words = 8886 sentences = 363 flesch = 34 summary = Trauma leads to the dysregulation of both the innate and adaptive immune responses, which places the injured at risk for several late consequences, including delayed wound healing, late onset sepsis and infection, multi-organ dysfunction syndrome, and acute respiratory distress syndrome, which are significant for their association with the increased morbidity and mortality of wounded personnel. Patients with less severe trauma may develop late MODS due to new surgical stress, general anesthesia, transfusion of blood products, infection, or ischemia/reperfusion injury triggering the reactivation of the inflammatory response in a "two-hit" model of MODS [19, 58] . Among these consequences, delayed wound healing, late onset sepsis and infection, multi-organ dysfunction syndrome, acute respiratory distress syndrome, and persistent inflammation-immunosuppression and catabolic syndrome are significant in their association with the increased morbidity and mortality of wounded personnel. cache = ./cache/cord-003615-vpzzsdld.txt txt = ./txt/cord-003615-vpzzsdld.txt === reduce.pl bib === id = cord-004186-m817oudw author = Iwata, Shihoko title = Anesthetic management of a patient with a continuous-flow left ventricular assist device for video-assisted thoracoscopic surgery: a case report date = 2020-01-20 pages = extension = .txt mime = text/plain words = 3769 sentences = 196 flesch = 45 summary = title: Anesthetic management of a patient with a continuous-flow left ventricular assist device for video-assisted thoracoscopic surgery: a case report Here, we present the anesthetic management of a patient with a continuous-flow LVAD who underwent video-assisted thoracic surgery (VATS). In the present case, when the patient was set in a lateral decubitus position and progressive hypoxia was observed during OLV, transesophageal echocardiography demonstrated a dilated right ventricle and a temporally flattened interventricular septum, and the central venous pressure increased to approximately 20 mmHg. Because we anticipated deterioration of right heart function, dobutamine and milrinone were administered and/or respirator settings were changed to decrease PVR for maintaining LVAD performance. CONCLUSIONS: The anesthetic management of a patient with LVAD during VATS is challenging because the possible hemodynamic changes induced by hypoxia associated with OLV affect LVAD performance and right heart function. Anesthetic management of patients with continuous-flow left ventricular assist devices undergoing noncardiac surgery: an update for anesthesiologists cache = ./cache/cord-004186-m817oudw.txt txt = ./txt/cord-004186-m817oudw.txt === reduce.pl bib === id = cord-004643-uu4uipfy author = Hasan, Mohammad Rubayet title = Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report date = 2020-03-20 pages = extension = .txt mime = text/plain words = 3015 sentences = 151 flesch = 35 summary = Here, we present a fatal case of HLH secondary to cytomegalovirus (CMV) infection complicated by both anti-viral drug resistance and sepsis from multiple MDROs including pandrug-resistant superbug bacteria. Whole genome sequencing (WGS) of the MDR bacteria and metagenomic analysis of his blood sample revealed an unusual accumulation of a wide range of antimicrobial resistance mechanisms in a single patient, including antiviral resistance to ganciclovir, and resistance mechanisms to all currently available antibiotics. Ganciclovir resistance was confirmed by the presence of the A594V mutation in UL97 [6] What was unique in our patient compared to other reported CMV-associated HLH cases was the overwhelming infection with MDROs. On hospital admission, the patient was found to be colonized with multiple MDROs including VRE, and carbapenamase-producing Enterobacteriaceae, which may have been acquired during his previous hospital course in India. cache = ./cache/cord-004643-uu4uipfy.txt txt = ./txt/cord-004643-uu4uipfy.txt === reduce.pl bib === id = cord-004339-7nwpic3d author = Rennie, Katherine J. title = Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction date = 2020-02-13 pages = extension = .txt mime = text/plain words = 8397 sentences = 455 flesch = 43 summary = Secondly, consent to have the discussion about the NAIROS trial with the investigator audio-recorded and their details passed onto • Any prior septal surgery • Systemic inflammatory disease or the use of any current oral steroid treatment within the past 2 weeks • Granulomatosis with polyangiitis • Nasendoscopic evidence of unrelated associated pathology, e.g. adenoid pad, septal perforation, chronic rhinosinusitis indicated by the presence of polyposis or pus • Any history of intranasal recreational drug use within the past 6 months • Breast-feeding, pregnancy or intended pregnancy for the duration of involvement in the trial • Bleeding diathesis • Therapeutic anticoagulation (warfarin/novel oral anti-coagulant (NOAC) therapy) • Clinically significant contraindication to general anaesthesia • Patients known to be immuno-compromised • Those in whom an external bony deformity substantially contributes to the nasal obstruction a member of the qualitative team for a telephone interview. cache = ./cache/cord-004339-7nwpic3d.txt txt = ./txt/cord-004339-7nwpic3d.txt === reduce.pl bib === id = cord-005420-60ie0pfd author = Sparrelid, E title = Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection date = 1998-10-09 pages = extension = .txt mime = text/plain words = 3830 sentences = 223 flesch = 47 summary = title: Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection Episodes of bacteraemia during the aplastic phase were studied in 500 allogeneic bone marrow (BMT) recipients, regarding incidence, microbial aetiology, risk factors, mortality and causes of death. Among patients with negative blood cultures during the aplastic phase, 6/25 died of invasive fungal infection (three candida, one saccaromyces and two aspergillus). Invasive candida infection was defined as either candidaemia, and/or positive cultures from at least two organs, except the gastrointestinal tract when obtained at autopsy, in patients who died within 60 days after BMT. Risk factors analysed were recipient age and gender, donor age and gender, pretransplant diagnosis, disease stage (low risk for transplantation-related mortality (TRM): acute leukaemia in 1st complete remission, CML 1st chronic phase, aplastic anaemia, metabolic disorders; high risk for TRM: others), pretransplant serology for cytomegalovirus (CMV) and herpes simplex virus (HSV) in the recipient, HLAmatch, related and unrelated donors, conditioning regimen (TBI or not), splenectomy, type of GVHD prophylaxis and bone marrow cell dose. cache = ./cache/cord-005420-60ie0pfd.txt txt = ./txt/cord-005420-60ie0pfd.txt === reduce.pl bib === id = cord-004949-icsey27p author = Fernandez-Botran, Rafael title = Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia date = 2014-02-21 pages = extension = .txt mime = text/plain words = 4044 sentences = 193 flesch = 43 summary = The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Compared to non-severe CAP patients, the severe CAP group showed higher plasma levels of proand anti-inflammatory cytokines but in contrast, lower sputum concentrations of pro-inflammatory cytokines. The objectives of this study were to characterize and contrast the lung and systemic cytokine profiles as well as blood neutrophil responses in patients with severe versus non-severe CAP at the time of hospital admission. In order to compare results of the plasma cytokines and neutrophil functional assays from CAP patients with those of healthy individuals, blood samples were also obtained from a control group (n=12) of healthy adult donors (approved by the University of Louisville′s IRB #191.06). Generally, patients in the severe CAP group showed a pattern with median plasma concentrations of both pro-and anti-inflammatory cytokines that were higher in comparison with the non-severe CAP group and the healthy control group. cache = ./cache/cord-004949-icsey27p.txt txt = ./txt/cord-004949-icsey27p.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-005503-hm8tvkt3 author = Rasulo, Frank A. title = Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient date = 2020-03-24 pages = extension = .txt mime = text/plain words = 5987 sentences = 278 flesch = 35 summary = Recently, automated infrared pupillometry has been introduced into clinical practice, quickly gaining popularity due to its quantitative precision, low cost, noninvasiveness, bedside applicability, and easy-to-use technology, contributing to a modern precision-oriented approach to medicine. reported that power mode transcranial Doppler had high sensitivity and specificity for diagnosis of brain death, respectively 100% and 98% (flow velocity was assessed in the middle cerebral artery using a transtemporal approach) [32] (Fig. 9 ). Processed EEG was originally intended for the management of the anesthetic state during surgery to avoid accidental awareness and to titrate sedation in critically ill patients where clinical scales represent the gold standard. In addition, clinical scale assessment is performed by disturbing sedated or sleeping patients (processed EEG does not require modification of the sedation state) and can never identify phases of burst suppression or isoelectric traces (total suppression) [39] , which are associated with negative outcomes (e.g., delirium occurrence, prolonged mechanical ventilation, mortality). cache = ./cache/cord-005503-hm8tvkt3.txt txt = ./txt/cord-005503-hm8tvkt3.txt === reduce.pl bib === id = cord-005481-00rezmqj author = Reid, T title = Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial date = 2001-11-22 pages = extension = .txt mime = text/plain words = 6637 sentences = 355 flesch = 44 summary = [21] [22] [23] Tumor-selective viral replication and necrosis were demonstrated, and the treatment was well-tolerated without dose-limiting toxicities; flu-like symptoms and injection site pain were frequently noted. [24] [25] [26] [27] While all recurrent head and neck cancer patients on the combination viral and chemo-therapy clinical trial received intravenous chemotherapy (cisplatin and 5-fluorouracil), the response rate of tumors injected with ONYX-015 was significantly higher than in tumors that were not injected. Therefore, based on the favorable clinical toxicity and efficacy profile with intratumoral injection, and preclinical efficacy following intravascular administration, we performed a phase I/II dose escalation trial of ONYX-015 administered via the hepatic artery to patients with metastatic gastrointestinal carcinomas (primarily colorectal) to the liver. We performed a phase I dose-escalation trial of the replication-selective adenovirus ONYX-015 administered by hepatic arterial infusion, alone and in combination with intravenous 5-FU and LV, in patients with liver metastases from gastrointestinal carcinomas. cache = ./cache/cord-005481-00rezmqj.txt txt = ./txt/cord-005481-00rezmqj.txt === reduce.pl bib === === reduce.pl bib === id = cord-005452-ouookpd8 author = Ghosh, K title = Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation date = 1999-04-19 pages = extension = .txt mime = text/plain words = 1154 sentences = 77 flesch = 51 summary = title: Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation A 13-year-old patient with transfusion-dependent β thalassemia major developed acute regimen-related lung toxicity after the conditioning regimen but before allogeneic bone marrow transplantation. Advances in non-invasive ventilatory support may drastically improve the outlook of this subset of patients who otherwise have a grim prognosis Rabitsch et al 1 reported successful management of adult respiratory distress syndrome by non-invasive ventilatory support. On this intermittent CPAP the patient steadily improved, received his allogeneic marrow graft from his brother engrafting by day +9. It has also been suggested that this modality of management should be severely restricted 3 in allogeneic BMT patients, particularly during their first +100 days. Successful management of adult respiratory distress syndrome (ARDS) after high dose chemotherapy and peripheral blood progenitor cell rescue by non-invasive ventilatory support Non-invasive pressure support ventilation in patients with acute respiratory failure. cache = ./cache/cord-005452-ouookpd8.txt txt = ./txt/cord-005452-ouookpd8.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-005487-vac061r8 author = nan title = Physicians Abstracts: EBMT 2010 date = 2010-04-07 pages = extension = .txt mime = text/plain words = 58975 sentences = 3128 flesch = 58 summary = We retrospectively analyzed 1257 patients (pts), 755 children (age≤18) and 502 adults, receiving fi rst single (n = 1080) or double UCBT (n = 177) in EBMT centers, between 1995 and 2009 , for malignant and non-malignant diseases, who survived at least 100 days from transplantation with neutrophils recovery and without relapse or autologous reconstitution. Prochymal® improves response rates in patients with steroid-refractory acute graft-versus-host disease involving the liver and gut: results of a randomized, placebo-controlled, multicentre phase III trial in GvHD P.J. Martin (1) , J.P. Uberti (2) Background and methods: Steroid-refractory acute GVHD (SR-GVHD) remains a signifi cant and life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). A. Nagler (1) Background: Allogeneic transplantation of hematopoietic stem cells (allo-SCT) from an HLA-matched related (MRD) or unrelated donor (URD) is a curative option for patients (pts) with high-risk hematological disease (HRHD). cache = ./cache/cord-005487-vac061r8.txt txt = ./txt/cord-005487-vac061r8.txt === reduce.pl bib === id = cord-005569-9d51l6bn author = Antonelli, Massimo title = Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia date = 2008-12-09 pages = extension = .txt mime = text/plain words = 10270 sentences = 507 flesch = 39 summary = Key recommendations, listed by category, include: early goal-directed resuscitation of the septic patient during the first 6 h after recognition (1C); blood cultures prior to antibiotic therapy (1C); imaging studies performed promptly to confirm potential source of infection (1C); administration of broad-spectrum antibiotic therapy within 1 h of diagnosis of septic shock (1B) and severe sepsis without septic shock (1D); reassessment of antibiotic therapy with microbiology and clinical data to narrow coverage, when appropriate (1C); a usual 7-10 days of antibiotic therapy guided by clinical response (1D); source control with attention to the balance of risks and benefits of the chosen method (1C); administration of either crystalloid or colloid fluid resuscitation (1B); fluid challenge to restore mean circulating filling pressure (1C); reduction in rate of fluid administration with rising filling pressures and no improvement in tissue perfusion (1D); vasopressor preference for norepinephrine or dopamine to maintain an initial target of mean arterial pressure [ or =65 mm Hg (1C); dobutamine inotropic therapy when cardiac output remains low despite fluid resuscitation and combined inotropic/vasopressor therapy (1C); stress-dose steroid therapy given only in septic shock after blood pressure is identified to be poorly responsive to fluid and vasopressor therapy (2C); recombinant activated protein C in patients with severe sepsis and clinical assessment of high risk for death (2B except 2C for post-operative patients). cache = ./cache/cord-005569-9d51l6bn.txt txt = ./txt/cord-005569-9d51l6bn.txt === reduce.pl bib === id = cord-005147-mvoq9vln author = nan title = Autorenregister date = 2017-02-23 pages = extension = .txt mime = text/plain words = 86573 sentences = 4356 flesch = 45 summary = Using whole-exome sequencing and trio-based de novo analysis, we identified a novel heterozygous de novo frameshift variant in the leukemia inhibitory factor receptor (LIFR) gene causing instability of the mRNA in a patient presenting with bilateral CAKUT and requiring kidney transplantation at one year of age. Loss of cdkl5 associated with deficient mammalian target of rapamycin (mTOR) signaling in mice and human cells We and other groups have shown that mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a severe neurodevelopmental disorder with clinical features including intellectual disability, early-onset intractable seizures and autism, that are closely related to those present in Rett syndrome (RTT) patients. Functional characterization of novel GNB1 mutations as a rare cause of global developmental delay Over the past years, prioritization strategies that combined the molecular predictors of sequence variants from exomes and genomes of patients with rare Mendelian disorders with computer-readable phenotype information became a highly effective method for detecting disease-causing mutations. cache = ./cache/cord-005147-mvoq9vln.txt txt = ./txt/cord-005147-mvoq9vln.txt === reduce.pl bib === id = cord-005480-yg7salqt author = nan title = Oral Sessions and Working Party date = 2008-03-26 pages = extension = .txt mime = text/plain words = 72626 sentences = 3873 flesch = 55 summary = Standard NIH or Eurolupus cyclophosphamide (CY) protocols and mycophenolate Mofetil (MMF) as induction therapy in severe BILAG A SLE is still associated with 20 % failure, 50% relapse and 10% to 15 % death at 10 years In the absence of a single standard treatment worldwide for refractory SLE, phase I-II studies analysed the use of: a) rituximab (anti CD20 mAb) in more than 1 000 patients showing complete to partial early response around 100% with relapse in 50 to 60% of the cases; b) autologous Hematopoietic Stem Cell Transplantation (HSCT) since 1997 under the auspices of the joined EBMT-EULAR working party, reporting durable remission with reduced or no immunosuppressive drug requirement in 66%, one-third of whom later relapsed to some degree with a 74 ± 7% (n= 62/79) overall survival at 5 years for SLE among the 863 HSCT procedures registered: in 2007 in the EBMT data base. cache = ./cache/cord-005480-yg7salqt.txt txt = ./txt/cord-005480-yg7salqt.txt === reduce.pl bib === === reduce.pl bib === id = cord-005478-5iu38pr6 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date = 2019-07-03 pages = extension = .txt mime = text/plain words = 63350 sentences = 3869 flesch = 58 summary = There were some differences among groups: patients in group-1 were younger (median age 46 years, p< 0.02) were transplanted in more recent year (2015, p< 0.001), received more frequently a regimen based on TBF (thiotepa, fludarabine and busulfan) (83%, p< 0.001) and bone marrow (BM) as source of stem cells (77%, p< 0.001), with no ATG (100%, p< 0.001). Clinical Trial Registry: NCT01217723 Disclosure: None of the Authors have any conflicts of interest to declare O105 Immune reconstitution -based score at diagnosis of CGVHD predicts GVHD severity and overall-survival: A novel prognostication tool for GVHD treatment tailoring Background: Allogeneic stem cell transplantation (HSCT) survivors are at a relevant risk of developing chronic GvHD (cGvHD), which importantly affects quality of life and increases morbidity and mortality. cache = ./cache/cord-005478-5iu38pr6.txt txt = ./txt/cord-005478-5iu38pr6.txt === reduce.pl bib === id = cord-005697-l1zmrq4p author = Pène, Frédéric title = Is this critically ill patient immunocompromised? date = 2015-12-02 pages = extension = .txt mime = text/plain words = 1344 sentences = 67 flesch = 29 summary = A subset of septic patients infected with highly virulent pathogens may die rapidly from refractory shock, disseminated intravascular coagulation, and intractable multiple organ failure as a result of hyper-cytokinemia and uncontrolled inflammatory response. However, with improvements in acute care and resuscitation therapies, this classical exuberant presentation is relatively rare nowadays, and the physician is more often challenged by a blunted clinical response to infection, with subtle findings including lethargy or depressed mental status, glucose intolerance and hyperglycemia, hypothermia, and/or a change in the white blood cell count or cell differential. In addition to overt immunosuppressive conditions (e.g., cancer and hematological malignancies, solid organ transplant, autoimmune and systemic diseases, HIV, use of immunosuppressive drugs), many septic patients commonly exhibit additional risk factors affecting immune status [3] . Regardless of underlying comorbidities and primary injuries responsible for ICU admission, a significant proportion of critically ill patients can reasonably be considered to be immunocompromised and at risk for ICU-acquired infections, especially if they develop overt signs of immunosuppression. cache = ./cache/cord-005697-l1zmrq4p.txt txt = ./txt/cord-005697-l1zmrq4p.txt === reduce.pl bib === === reduce.pl bib === id = cord-006179-7uv4yfv2 author = Cheuk, Daniel Ka Leung title = Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children date = 2007-09-29 pages = extension = .txt mime = text/plain words = 4580 sentences = 211 flesch = 46 summary = Autologous hematopoietic stem cell transplant (AHSCT) has been advocated as a form of salvage therapy for children with high-risk or relapsed brain tumors but only limited data are available currently. Over the past decade, high-dose chemotherapy with autologous hematopoietic stem cell transplant (AHSCT) has been tried in patients with high-risk brain tumors in an attempt to eradicate residual neoplastic cells and improve cure rate. In conclusion, AHSCT can result in long-term survival with satisfactory functional status in children with recurrent brain tumors, especially for those who can achieve complete remission before transplant. High-dose busulfan and thiotepa with autologous bone marrow transplantation in childhood malignant brain tumors: a phase II study High-dose melphalan and cyclophosphamide with autologous bone marrow rescue for recurrent/progressive malignant brain tumors in children: a pilot pediatric oncology group study High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors cache = ./cache/cord-006179-7uv4yfv2.txt txt = ./txt/cord-006179-7uv4yfv2.txt === reduce.pl bib === id = cord-005646-xhx9pzhj author = nan title = 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date = 1996 pages = extension = .txt mime = text/plain words = 72031 sentences = 4734 flesch = 56 summary = Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer's exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. cache = ./cache/cord-005646-xhx9pzhj.txt txt = ./txt/cord-005646-xhx9pzhj.txt === reduce.pl bib === id = cord-005105-twsy61oq author = nan title = SIU 2015 Abstracts date = 2015-09-21 pages = extension = .txt mime = text/plain words = 124096 sentences = 7584 flesch = 54 summary = Th e present study is based on a retrospective analysis of a database of over 600 patients (age range 17-57 years) who met the consensus criteria for bacterial prostatitis, 75% of whom had dysuria, 35% perineal discomfort, 60% had obstructive luts, 37% infertility of unknown etiology, 10% erectile dysfunction and 25% recurrent infection of the partner. Further research is needed to determine to assess whether localization of small volume disease on 68Ga-PSMA PET/CT can improve diagnostic algorithms and outcomes in patients with recurrent PCa. Introduction and Objective: To assess long-term results of salvage pelvic lymph node dissection (PLND) in prostate cancer (PC) patients (pts) with biochemical recurrence aft er primary local treatment and confi rmed solitary lymph node (LN) metastases. cache = ./cache/cord-005105-twsy61oq.txt txt = ./txt/cord-005105-twsy61oq.txt === reduce.pl bib === id = cord-005819-fp5khzd5 author = Bonatz, K. title = Gram-negative bacterial pneumonia with secondary aspergillosis in an AIDS patient date = 1991 pages = extension = .txt mime = text/plain words = 1651 sentences = 109 flesch = 36 summary = title: Gram-negative bacterial pneumonia with secondary aspergillosis in an AIDS patient After the initial success of therapy and a symptom-free period, she developed pneumonia with septic shock and adult respiratory distress syndrome (ARDS). The largest study of invasive aspergillosis so far, with 13 HIV-infected patients, documents the diagnostic difficulties, as positive diagnosis mostly required bronchoalveolar lavage or transthoracic aspiration of pulmonary lesions. The cases of AIDS patients with invasive aspergillosis described in the literature therefore had neutropenia related to zidovudine or to ganciclovir therapy, increased exposure to aspergillus by marijuana smoking, underlying pulmonary disease, or corticosteroid use as predisposing factors. It also indicates the possibility of increasing confrontation with disseminated fungal infections like invasive aspergillosis as secondary neutropenia due to drugs such as zidovudine and ganciclovir becomes more common. Bacterial pneumonia in patients with human immunodeficiency virus infection Aspergillus endocarditis and myocarditis in a patient with the acquired immunodeficiency syndrome (AIDS) Bacterial infections in AIDS patients cache = ./cache/cord-005819-fp5khzd5.txt txt = ./txt/cord-005819-fp5khzd5.txt === reduce.pl bib === id = cord-005705-j765ruj1 author = Dreyfuss, Didier title = Is it better to consent to an RCT or to care?: Μηδεν αγαν (“nothing in excess”) date = 2004-12-17 pages = extension = .txt mime = text/plain words = 7508 sentences = 375 flesch = 47 summary = Another contention of the present paper is this [14] : critical care physicians may still believe that RCTs remain the best tool for improving knowledge and care, and in this case they must accept to use the means needed to achieve the end and therefore to insist on mandatory informed consent from the patient or proxy; or they may realize that the game is not worth the candle and they must then turn to other forms of research that are ranked less highly in the pyramid of evidence-based medicine [15] . Before discussing the problem of informed consent to research a critical appraisal of the scientific and ethical validity of RCTs in critical care medicine is in order. cache = ./cache/cord-005705-j765ruj1.txt txt = ./txt/cord-005705-j765ruj1.txt === reduce.pl bib === id = cord-006181-fkh2fzbr author = Bednarczyk, Joseph M. title = Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date = 2015-04-08 pages = extension = .txt mime = text/plain words = 3529 sentences = 232 flesch = 42 summary = This report describes the clinical course of four consecutive patients with blastomycosis-related ARDS treated with venovenous extracorporeal membrane oxygenation (ECMO) during 2009-2014. 3 Venovenous extracorporeal membrane oxygenation (ECMO) has been utilized for the management of severe ARDS to facilitate gas exchange, allow lung rest by deescalation of ventilatory support, and provide time for resolution of the underlying disease. 7 Extracorporeal membrane oxygenation is generally considered in ARDS patients with refractory hypoxemia or hypercapnia despite a lung protective ventilation strategy or in those where the maintenance of adequate gas exchange requires potentially injurious applied volumes or pressures. Extracorporeal membrane oxygenation may be an effective treatment modality for patients with blastomycosis-related ARDS and refractory hypoxemia despite optimal mechanical ventilation. Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) in fulminant blastomycosis in Germany cache = ./cache/cord-006181-fkh2fzbr.txt txt = ./txt/cord-006181-fkh2fzbr.txt === reduce.pl bib === id = cord-005692-n4vxazst author = Papazian, Laurent title = Ventilator-associated pneumonia in adults: a narrative review date = 2020-03-10 pages = extension = .txt mime = text/plain words = 10361 sentences = 448 flesch = 27 summary = Empirical treatment takes into account the underlying disease and its severity, the presence of risk factors for multiple-drug-resistant pathogens (antibiotic therapy in the previous 90 days, hospital stay > 5 days, septic shock at VAP onset, ARDS prior to VAP onset, acute renal replacement therapy prior to VAP onset, previous colonization with MDR pathogen) and local pattern of antimicrobial susceptibility. While lower respiratory tract surveillance cultures may help to predict the involvement of MDR microorganisms in patients that develop VAP and thus decrease unnecessary broad-spectrum antibiotics use, there are no clear data that this strategy improves clinical outcomes or lowers costs [89, 90] . Subglottic secretion drainage has repeatedly been associated with lower VAP rates in both individual randomized trials and meta-analyses but does not appear to shorten the time to extubation, ICU length-of-stay, prevent ventilator-associated events, or lower mortality rates [94] . Effect of oropharyngeal povidone-iodine preventive oral care on ventilator-associated pneumonia in severely brain-injured or cerebral hemorrhage patients: a multicenter, randomized controlled trial cache = ./cache/cord-005692-n4vxazst.txt txt = ./txt/cord-005692-n4vxazst.txt === reduce.pl bib === id = cord-005861-3k8h3euj author = Gravenstein, J. S. title = Safety in anesthesia date = 2014-03-17 pages = extension = .txt mime = text/plain words = 3660 sentences = 213 flesch = 50 summary = Efforts to enhance safety in anesthesia must include adherence to explicit and implicit safety standards, must make use of equipment that offers modern safety features, must seek to detect and correct developing safety threats as early as possible and must have a structured system to analyze problems and to institute remedies to prevent their recurrence. The health care system in which these fatal and non-fatal errors occur covers a spectrum that stretches from the manufacturers of equipment and drugs to the cleaning crew in the operating room and it involves many different clinical and supportive departments and their personnel.Anesthesia is an important component of this health care system comprising many interdependent parts that can affect the quality of anesthesia care. The Institute of Medicine [5] includes in its definitions the terms "accidental injury" and, interestingly, makes reference to a process:"Ensuring patient safety involves the establishment of operational systems and processes that minimize the likelihood of errors and maximize the likelihood of intercepting them when they occur." cache = ./cache/cord-005861-3k8h3euj.txt txt = ./txt/cord-005861-3k8h3euj.txt === reduce.pl bib === id = cord-005992-mu917isy author = nan title = Abstracts der 49. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date = 2011-10-23 pages = extension = .txt mime = text/plain words = 19250 sentences = 2049 flesch = 52 summary = Es bleiben aber eine Reihe von IH übrig, welche an weniger auffälligen Lokalisationen sind, bei sehr jungen Säuglingen gerade im Entstehen, und solche bei denen die Relation zu einer systemischen Therapie grenzwertig ist. Auf Grund einer initial als Mutation beschrieben Veränderung des HNF1a Gens wurde die Diagnose MODY 3 gestellt und die Therapie von Insulin auf Sulfonylharnstoff umgestellt. SSW Der Patient zeigt ein sehr auffälliges Trinkverhalten (beim Trinken kommt es zum Zurückfließen von Milch aus dem Mund) sowie einen in-und exspiratorischen Stridor, die durchgeführten Untersuchungen bleiben jedoch ohne pathologischen Befund. Wir konnten auch zeigen, dass insbesondere bei Kindern mit B-Zellvorläufer ALL die Kombination von beiden MRD-Zeitpunkten prognostisch bedeutsam ist, da zum Beispiel Patienten mit einer MRD von ≥10 −3 am Tag 33 und jeglichem positivem Signal am Tag 78 ein schlechtes Ergebnis vorwiesen. In einer Pilotstudie konnten wir zeigen, dass durch Modifikation der Probenaufbereitung ein Einsatz des Roche Septifast-Systems bei Frühgeborenen mit einem geringen Blutvolumen von minimal 100 µl möglich ist. cache = ./cache/cord-005992-mu917isy.txt txt = ./txt/cord-005992-mu917isy.txt === reduce.pl bib === id = cord-006302-pnnkfid0 author = Ioakeimidou, A. title = Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction date = 2017-04-28 pages = extension = .txt mime = text/plain words = 2944 sentences = 160 flesch = 51 summary = We studied the follow-up changes of circulating vasoactive peptides and cytokines until the improvement or the worsening of a patient and progression into specific organ dysfunctions. In a prospective study, concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), endocan and angiopoietin-2 (Ang-2) were measured in serum by an enzyme immunoassay in 175 patients at baseline; this was repeated within 24 h upon progression into new organ dysfunction (n = 141) or improvement (n = 34). Our aims were to monitor the changes of circulating levels of pro-inflammatory and antiinflammatory cytokines and of vasoactive peptides of critically ill patients at well-defined time-points of the clinical course and to understand how these changes mediate progression to organ dysfunction in an individualized way. When pair-wise comparisons between baseline and follow-up measurements were done within the subgroups of patients developing new organ dysfunctions, it was found that the only parameters significantly changing were endocan and Ang-2. cache = ./cache/cord-006302-pnnkfid0.txt txt = ./txt/cord-006302-pnnkfid0.txt === reduce.pl bib === id = cord-006544-yr4u61qv author = Miesbach, W. title = Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation date = 2004-03-20 pages = extension = .txt mime = text/plain words = 3867 sentences = 223 flesch = 35 summary = title: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation Over the preceding 3 years the patient had presented a wide spectrum of manifestations of APS, including recurrent venous and arterial thromboses, cardiac, gynecological (HELLP syndrome), neurological involvements, livedo reticularis, a mild thrombocytopenia and the most feared manifestation of the catastrophic antiphospholipid syndrome (CAPS). The antiphospholipid syndrome (APS) is one of the most common causes of acquired thrombophilia and is characterized by arterial and/or venous thrombosis, recurrent pregnancy losses, and the laboratory evidence of antibodies against phospholipids or phospholipidbinding protein cofactors [1] . Retrospective studies suggest that patients with APS have an increased risk of recurrent thromboembolism [4, 5, 6] , and for this reason it is recommended that they receive oral vitamin K antagonists, such as warfarin, in order to achieve an international normalized ratio (INR) range within a therapeutic level (INR fi 3). cache = ./cache/cord-006544-yr4u61qv.txt txt = ./txt/cord-006544-yr4u61qv.txt === reduce.pl bib === id = cord-005717-x7gsqlwp author = Hauser, Gabriel J. title = Pediatric intestinal and multivisceral transplantation: a new challenge for the pediatric intensivist date = 2008-05-24 pages = extension = .txt mime = text/plain words = 5190 sentences = 260 flesch = 29 summary = RESULTS: Preoperative management focuses on optimization of organ function, minimizing ventilator-induced lung injury, preventing excessive edema yet maintaining adequate organ perfusion, preventing and controlling sepsis and bleeding from varices at enterocutaneous interfaces, and optimizing nutritional support. Critical care immediately after intestinal transplantation (Table 2) is influenced by the overall state of health of the patient at the time of surgery, specific organs included in the composite graft, hemodynamic stability in the operating room, and immediate graft function. Patients with multivisceral transplants usually remain intubated for several days, particularly when large graft size mandates delayed abdominal closure (Table 3) , however, the priority must be early extubation to reduce the risk of ventilator-associated pneumonia. When the primary indication for transplantation is declining central vein access, patients that are managed by a competent intestinal failure team usually present with appropriate nutritional status. Pre-transplant nutritional management of patients who are in both liver and intestinal failure is more challenging [40] . cache = ./cache/cord-005717-x7gsqlwp.txt txt = ./txt/cord-005717-x7gsqlwp.txt === reduce.pl bib === id = cord-006518-al94gxjw author = Calder, Philip C. title = n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients date = 2004 pages = extension = .txt mime = text/plain words = 10029 sentences = 518 flesch = 43 summary = More recent studies showed that EPA did not induce TNF-α, IL-1β, or IL-1α (68) or IL-6 (69) in osteoblasts, and even countered the upregulating effect of arachidonic acid (68) ; that EPA and DHA could totally abolish cytokine-induced up-regulation of TNF-α, IL-1α, and IL-1β in cultured bovine chondrocytes and in human osteoarthritic cartilage explants (93, 94) ; and that EPA or fish oil inhibited endotoxin-induced TNF-α production by monocytes (111) (112) (113) (114) . Animal feeding studies with fish oil support the observations made in cell culture with respect to the effects of long-chain n-3 FA on NFκB activation and inflammatory cytokine production. Several studies in humans involving supplementation of the diet with fish oil have demonstrated decreased production of TNF-α, IL-1β, and IL-6 by endotoxin-stimulated monocytes or mononuclear cells (a mixture of lymphocytes and monocytes) (80) (81) (82) 119) . cache = ./cache/cord-006518-al94gxjw.txt txt = ./txt/cord-006518-al94gxjw.txt === reduce.pl bib === id = cord-006545-c12m75gq author = Pinilla, Inmaculada title = Radiological prognostic factors in patients with pandemic H1N1 (pH1N1) infection requiring hospital admission date = 2011-05-27 pages = extension = .txt mime = text/plain words = 3045 sentences = 169 flesch = 45 summary = The aim of this study was to determine the radiologic findings associated with admission to the intensive care unit (ICU) and the development of acute respiratory distress syndrome (ARDS) in patients with pH1N1 infection. A higher number of lung zones involved and consolidation on the initial chest radiograph as well as a rapid progression of the radiological abnormalities were identified in patients requiring ICU admission and development of ARDS. Several reports describe the initial radiographic and CT findings in patients with H1N1 infection of both mild and severe cases including interstitial markings, nodules, ground-glass opacities (GGO), and consolidations with focal, multifocal, or diffuse distribution [8] [9] [10] [11] [12] [13] [14] [15] . The presence on the initial chest radiograph of lung consolidation, multifocal, diffuse, and bilateral involvement (Fig. 2 ) was associated with a statistically higher risk of requiring ICU admission (p<0.001). cache = ./cache/cord-006545-c12m75gq.txt txt = ./txt/cord-006545-c12m75gq.txt === reduce.pl bib === id = cord-005795-sgi54hq8 author = Ely, E. title = The impact of delirium in the intensive care unit on hospital length of stay date = 2001-11-08 pages = extension = .txt mime = text/plain words = 4876 sentences = 217 flesch = 40 summary = Patients in the intensive care unit (ICU) are at very high risk for the development of delirium due to factors such as multi-system illnesses and comorbidities, the use of psychoactive medications, and age. While recent studies have selected delirium and pharmacologic issues (which are inter-related) as two of the top three most important target areas for quality of care improvement in vulnerable older adults [13] , nearly all delirium investigations have excluded medical ICU patients who are often receiving prolonged sedation on mechanical ventilators [1, 2, 14, 15, 16, 17] . Two study nurses enrolled patients each morning and recorded baseline demographics, severity of illness data using the Acute Physiology and Chronic Health Evaluation (APACHE) II score [21] , activities of daily living [22] , and risk factors for delirium derived from data in the literature [2, 3, 14, 15, 23, 24, 25, 26, 27] . cache = ./cache/cord-005795-sgi54hq8.txt txt = ./txt/cord-005795-sgi54hq8.txt === reduce.pl bib === id = cord-006841-3u56erru author = Einsele, Hermann title = Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) date = 2003-09-10 pages = extension = .txt mime = text/plain words = 5273 sentences = 281 flesch = 34 summary = The number of stem cells in the graft and the type of GvHD prophylaxis are factors which determine the rate of hematopoeitic reconstitution and may therefore also influence incidence and severity of infections during the early post-transplantation period. Modification of empiric antimicrobial regimens in patients with neutropenic fever after allogeneic stem cell transplantation When the causative agent of an infection has been identified, antibacterial therapy should be adapted according to the resistance pattern of the pathogen. If fever occurs in a patient later than 100 days after allogeneic stem cell transplantation, the upper and lower respiratory tract (bronchitis, pneumonia, sinusitis), and bacteremias have to be considered as specific foci of infections. Clinical manifestations of adenovirus infections in patients after allogeneic stem cell transplantation that have been reported so far include pneumonia, hepatitis, cystitis, diarrhea, and also disseminated disease (for diagnostic procedures see Table 3 ). cache = ./cache/cord-006841-3u56erru.txt txt = ./txt/cord-006841-3u56erru.txt === reduce.pl bib === id = cord-006236-2gpwf4z2 author = nan title = Abstracts from the First International Conference on Heart Failure in Children and Young Adults date = 2004 pages = extension = .txt mime = text/plain words = 13113 sentences = 882 flesch = 55 summary = Key words: Gene Expression, Ventricular Hypertrophy, and Congenital Heart Disease Background: Extracorporeal membrane oxygenation (ECMO) can be used to support children with severe graft failure after heart transplant (Tx). In the 2 pts with graft failure from acute rejection, ECMO duration was 5 and 6 days; both regained normal heart function and were successfully decannulated without complications. Key words: ECMO, Heart Transplant, Graft Failure, Acute Hemodynamic Rejection Background: Ventricular assist device (VAD) support is well established in treating adults with end-stage heart disease. Key words: Mechanical circulatory support, Pediatric, VAD, Congenital Heart Disease, and Cardiomyopathy Background: Measurement of whole blood B-type natriuretic peptide (BNP) levels has been shown to detect heart failure in adults presenting with dyspnea in the acute setting. Key words: levosimendan, heart failure, cardiomyopathy Methods: 20 children were studied, age range from 2 to 192 months (median 32.5 months). cache = ./cache/cord-006236-2gpwf4z2.txt txt = ./txt/cord-006236-2gpwf4z2.txt === reduce.pl bib === id = cord-006332-ikh45wuy author = Bengmark, Stig title = Nutritional Support to Prevent and Treat Multiple Organ Failure date = 1996 pages = extension = .txt mime = text/plain words = 6918 sentences = 433 flesch = 44 summary = Probiotic bacteria have several important functions in the colon: (1) production of nutrients for the mucosa: acetate, butyrate, propionate, other SCFAs, pyruvate, lactate, and amino acids (arginine, cysteine, glutamine); (2) production of micronutrients (␤ group and folic acid, antioxidants, and polyamines), histamine, 5-hydroxytryptamine, piperidine, tyramine, cadaverine, pyrrolidine, agmatine, putrescine; (3) prevention of overgrowth of PPMs; (4) stimulation of the immune system, especially the gut-associated lymphoid tissue (GALT) system: NO is produced by these bacteria in the mouth and GI tract; (5) elimination of toxins from the lumen; (6) participation in intestinal regulation, mucus utilization, nutrient absorption, GI motility, and blood flow through signaling substances such as NO. Studies of abilities of lactobacilli to ferment fiber in vitro, to survive the acidity of stomach and the bile acid contents of the small intestine, to adhere to the colonic mucosa, and to remain and function there after the supply stopped led us to identify a few human lactobacilli with great capability. cache = ./cache/cord-006332-ikh45wuy.txt txt = ./txt/cord-006332-ikh45wuy.txt === reduce.pl bib === id = cord-006679-nhbofufv author = Lucarelli, G. title = Bone marrow transplantation for thalassemia date = 1993 pages = extension = .txt mime = text/plain words = 2004 sentences = 86 flesch = 51 summary = Early trials of allogeneic bone marrow transplantation (BMT) for homozygous beta-thalassemia and the analyses of results of transplantation in patients less then 16 years old have allowed us to identify three classes of risk using the criteria of degree of hepatomegaly, the degree of portal fibrosis and the quality of the chelation treatment given before the transplant. Allogeneic bone marrow transplantation has proved to be a radical form of cure in those patients with an HLA identical donor found within the family.2-3We report here our experience on 491 patients transplanted since January 1981 on the base of their categorization into three classes of risk) MATERIAL The best results in term of engraftment, toxicity and GvHD prophylaxis were obtained with the association of BU 14 rag/ kg, CY 200 mg/kg and CSA alone from day-2 as GvHD prophylaxis. cache = ./cache/cord-006679-nhbofufv.txt txt = ./txt/cord-006679-nhbofufv.txt === reduce.pl bib === id = cord-006750-cg2i2bae author = Stoots, Sarah Abramson title = Clinical Insights into Diffuse Alveolar Hemorrhage in Antiphospholipid Syndrome date = 2019-09-06 pages = extension = .txt mime = text/plain words = 5220 sentences = 303 flesch = 31 summary = PURPOSE OF REVIEW: Diffuse alveolar hemorrhage (DAH) is a rare but devastating manifestation of antiphospholipid syndrome (APS) patients with or without other systemic autoimmune diseases. In our experience, two different presentations of aPL-positive patients with DAH exist: (a) acute-with moderate to severe pulmonary hemorrhage (with varying degrees of respiratory failure) requiring hospitalization and (b) chronic-with mild hemoptysis, dyspnea, and/or positive imaging findings, usually seen as an outpatient. Antiphospholipid antibodies as a cause of pulmonary capillaritis and diffuse alveolar hemorrhage: a case series and literature review Difficulties in the treatment of recurring diffuse alveolar hemorrhage accompanying primary antiphospholipid syndrome: a case report and literature review Pulmonary capillaritis, alveolar hemorrhage, and recurrent microvascular thrombosis in primary antiphospholipid syndrome Rituximab induces resolution of recurrent diffuse alveolar hemorrhage in a patient with primary antiphospholipid antibody syndrome Primary antiphospholipid syndrome associated with diffuse alveolar hemorrhage and pulmonary thromboembolism cache = ./cache/cord-006750-cg2i2bae.txt txt = ./txt/cord-006750-cg2i2bae.txt === reduce.pl bib === id = cord-005808-w0763esk author = Moreno, Gerard title = Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study date = 2018-08-03 pages = extension = .txt mime = text/plain words = 5146 sentences = 311 flesch = 41 summary = CONCLUSION: Administration of corticosteroids in patients with severe influenza pneumonia is associated with increased ICU mortality, and these agents should not be used as co-adjuvant therapy. Therefore, the aim of the present study was to identify the factors associated with corticosteroid use and its impact on intensive care unit (ICU) mortality using propensity score (PS) matching analysis in ICU patients with influenza pneumonia. Our results strongly suggest that administration of corticosteroids as co-adjuvant therapy to standard antiviral treatment in critically ill patients with severe influenza pneumonia is associated with increased ICU mortality. Three recent systematic reviews and meta-analyses [41] [42] [43] concluded that corticosteroid therapy is significantly associated with mortality, even in the subgroup of patients with influenza hospitalized in or outside the ICU. In a homogeneous group of critically ill patients with severe influenza pneumonia, after adequate adjustment by PS matching and competing risks, co-adjuvant corticosteroid therapy was significantly associated with increased ICU mortality. cache = ./cache/cord-005808-w0763esk.txt txt = ./txt/cord-005808-w0763esk.txt === reduce.pl bib === id = cord-006394-ucthbqvt author = Pawlik, Timothy M. title = Combined Resection and Radiofrequency Ablation for Advanced Hepatic Malignancies: Results in 172 Patients date = 2003 pages = extension = .txt mime = text/plain words = 6124 sentences = 313 flesch = 45 summary = Conclusions: Resection combined with RFA provides a surgical option to a group of patients with liver metastases who traditionally are unresectable, and may increase long-term survival. Surgical resection of primary and metastatic liver tumors is considered to be the optimal treatment modality with a curative effect, offering a 5-year survival rate between 20% and 35%. For purposes of this study, the following were collected for all patients: patient age and sex; tumor histology, number, location, and size; type of surgical resection; operative details; disease status; follow-up date; death date; and complication data. Those patients who had more than 10 tumors treated with combined hepatic resection and RFA were significantly more likely to have a shorter time to recurrence than those with less disease (HR ϭ 1.63, CI ϭ 1.12-2.36, P ϭ .009). Our group of 172 patients treated with combined hepatic resection and RFA of malignant liver tumors is the largest series reported to date. cache = ./cache/cord-006394-ucthbqvt.txt txt = ./txt/cord-006394-ucthbqvt.txt === reduce.pl bib === id = cord-005750-54hul2lw author = Antonelli, Massimo title = Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea date = 2009-02-10 pages = extension = .txt mime = text/plain words = 8228 sentences = 436 flesch = 44 summary = In their paper, the authors present a detailed description of sequential analysis methodologies and describe their potential prospective use as tools for monitoring the performance of intensive care units. [2] undertook a study to determine whether outcomes were influenced by time of admission to an Australian tertiary paediatric intensive care unit without 24 h per day in-house intensivist cover. [6] who reported a prospective observational study across 15 Italian paediatric intensive care units conducted over a period of 1 year. In this randomised controlled trial, there was a significant difference in mortality rate with use of ACCM/ PALS haemodynamic support guidelines for septic shock between patients with or without ScvO 2 guided therapy. The authors concluded that their results support the finding that the clinical scales do not evaluate the level of sedation accurately in critically ill children with neuromuscular relaxation, leading to a higher risk of over or undersedation. cache = ./cache/cord-005750-54hul2lw.txt txt = ./txt/cord-005750-54hul2lw.txt === reduce.pl bib === id = cord-006621-0fxpn7qf author = Cantwell, Tamara title = Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date = 2017-10-10 pages = extension = .txt mime = text/plain words = 2503 sentences = 159 flesch = 38 summary = title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation The clinical relevance of the case is the scared evidence of leptospirosis-associated severe respiratory failure treated with ECMO. A high index of suspicion is needed for an adequate diagnosis of leptospirosis to implement the correct treatment, particularly in the association of respiratory failure, pulmonary hemorrhage, and an epidemiological-related context. Leptospirosis can present with a wide range of symptoms, mimicking flu, hepatitis, dengue, hanta virus cardiopulmonary syndrome, meningitis, among others, and has a specific treatment; thus, clinical suspicion must remain high and serological diagnosis should be performed. The most severe clinical form of leptospirosis is known as Weil's disease, which is uncommon (5-10% of cases), and is characterized by hepatic, renal, and pulmonary involvement [7] [8] [9] [10] [11] . In the case presented, profound septic shock, with MOF and catastrophic ARDS, made it impossible to ventilate the patient protectively and simultaneously supply adequate oxygenation and ventilation; thus, ECMO was initiated. cache = ./cache/cord-006621-0fxpn7qf.txt txt = ./txt/cord-006621-0fxpn7qf.txt === reduce.pl bib === id = cord-006523-zxn4oqly author = Lodha, Rakesh title = Nosocomial infections in pediatric intensive care units date = 2001 pages = extension = .txt mime = text/plain words = 5227 sentences = 340 flesch = 37 summary = The common nosocomial infections in PICU are bloodstream infections (20–30% of all infections), lower respiratory tract infections (20–35%), and urinary tract infections (15–20%); there may be some differences in their incidence in different PICUs. The risk of nosocomial infections depends on the host characteristics, the number of interventions, invasive procedures, asepsis of techniques, the duration of stay in the PICU and inappropriate use of antimicrobials. 3 In the same study, it was observed that 91% of all nosocomial bloodstream infections occurred in children with central venous lines, 95% of nosocomial pneumonias occurred in those on mechanical ventilation and 77% of UTIs in children with urinary catheters. Transtracheal aspiration in non-intubated patients, percutaneous thin needle lung aspirations, bronchoalveolar lavage (bronchoscopic or blind), and protected bronchoscopic samples of the lower airways have all been suggested as methods for diagnosis, where contamination of lower respiratory secretions with upper airway flora is prevent-ed29~~ In the absence of gold standard criteria for the diagnosis of ventilator-associated pneumonia, quantitative cultures and microscopic examination of the lower respiratory tract secretions are the diagnostic tests of choice. cache = ./cache/cord-006523-zxn4oqly.txt txt = ./txt/cord-006523-zxn4oqly.txt === reduce.pl bib === id = cord-005497-w81ysjf9 author = nan title = 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date = 2020-03-24 pages = extension = .txt mime = text/plain words = 103623 sentences = 6176 flesch = 53 summary = The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). cache = ./cache/cord-005497-w81ysjf9.txt txt = ./txt/cord-005497-w81ysjf9.txt === reduce.pl bib === id = cord-006343-c0amee70 author = Martinez Rivera, Andrea title = Intestinal transplantation in children: current status date = 2016-03-31 pages = extension = .txt mime = text/plain words = 4976 sentences = 247 flesch = 40 summary = Intestinal transplantation (IT) is the least common form of organ transplantation; however, it has shown exceptional growth and improvement in graft survival rates over the past two decades mainly due to better outcomes achieved during the first year of transplantation (76 % at 1 year), due to improvement in surgical techniques and the development of better immunosupressive therapies as we understand more about the relationship between the recipient and host immune system. It remains on the continuum of care for pediatric patients with intestinal failure, but bowel transplant rates have declined worldwide over the last 6 years, in large part due to the development of multidisciplinary intestinal rehabilitation programs and the control of progressive cholestatic liver disease with novel lipid-based management strategies. With improved clinical outcomes of pediatric patients with intestinal failure, there is increasing evidence that the current indications for bowel transplantation no longer apply and need revision. cache = ./cache/cord-006343-c0amee70.txt txt = ./txt/cord-006343-c0amee70.txt === reduce.pl bib === id = cord-006391-esnsa4u5 author = nan title = Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date = 1982 pages = extension = .txt mime = text/plain words = 44844 sentences = 2433 flesch = 50 summary = In our parallel tests using an excision-sample technique [2] which is considerably more sensitive than the DGHM procedure, we have observed the following mean reductions in the counts of accessible bacteria: iodine in ethanol, 96%; povidone-iodine, 89%; chlorhexidine in ethanol, 88%; iso-propanol, The purpose of this study was to compare radiation injury in Guinea Pig small bowel (1) devoid of contents (2) containing bile (3) containing pancreatic juice. Studies in vitro employing isolated perfused rat pancreas and stomach revealed following results: Mean basal pancreatic somatostatin release in normal, diabetic and transplanted rats were 12___3, 24-t-7, and 17__+4 pg/ml, respectively. As these changes appear closely correlated to the blood glucose levels which show a 30 % decrease at 4 h and progressive restoration towards normal values up to 24 h, attempts have been made to alter the insulin/glucagon ratio by glucose infusion after PH and study its relation to liver regeneration. cache = ./cache/cord-006391-esnsa4u5.txt txt = ./txt/cord-006391-esnsa4u5.txt === reduce.pl bib === id = cord-006000-ekwpkzqv author = Bewig, B. title = Eosinophilic alveolitis in BAL after lung transplantation date = 1999 pages = extension = .txt mime = text/plain words = 4206 sentences = 256 flesch = 40 summary = We analyzed 25 BAL samples and clinical data of 4 patients who underwent lung transplantation and presented with recurrent episodes of eosinophilic alveolitis in BAL. We analyzed 25 BAL samples and clinical data of 4 patients who underwent lung transplantation and presented with recurrent episodes of eosinophilic alveolitis in BAL. All patients demonstrated a deterioration of clinical condition, lung function, and blood gas analysis during times of eosinophilia in BAL, compared to previous examinations. In conclusion, eosinophilic alveolitis may indicate acute rejection in patients after lung transplantation, if other causes of eosinophilia are excluded. In conclusion, eosinophilic alveolitis may indicate acute rejection in patients after lung transplantation, if other causes of eosinophilia are excluded. In this retrospective study, clinical data and differential cell counts from BAL samples of 37 lung transplant recipients, who had been treated at the University of Kiel until December 1996 and were available for follow-up investigation, were analyzed. cache = ./cache/cord-006000-ekwpkzqv.txt txt = ./txt/cord-006000-ekwpkzqv.txt === reduce.pl bib === id = cord-005953-5z89yeb6 author = nan title = Abstracts des 114. Internistenkongresses 2008 date = 2008 pages = extension = .txt mime = text/plain words = 16135 sentences = 1522 flesch = 49 summary = Die anderen beiden Gruppen zeigten zwar in Hinblick auf die Wandstärken einen positiven Effekt, hinsichtlich der Herzfunktion konnten sie jedoch bei bereits deutlich erniedrigten Funktionswerten zum Baseline-Zeitpunkt lediglich stabilisiert werden (Reduktion der Wandstärke nach 3 Jahren ERT: Gruppe wenig Fibrose= 10 mm; Gruppe viel Fibrose= 12 mm) Schlussfolgerung: Die Enzymersatztherapie ist eine effektive Langzeitbehandlung bei Patienten mit Fabry Kardiomyopathie. Der Einfluss der sauren Sphingomyelinase auf die Expression von Matrix-Metalloproteinase-1 in intestinalen Epithelzellen und Fibroblasten Background: The calcineurin (Cn)/NF-AT signaling cascade takes a crucial role during T-cell activation and the development of myocardial hypertrophy. Effective and safe reduction of blood pressue by the combination of amlodipine 5/valsartan 160 mg in patients with hypertension and metabolic risk factors not controlled by amlodipine 5 mg or felodipine 5 mga subanalysis of the express-m trial Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia and frequently occurs in patients with coronary heart disease. cache = ./cache/cord-005953-5z89yeb6.txt txt = ./txt/cord-005953-5z89yeb6.txt === reduce.pl bib === id = cord-006563-qmigctkp author = nan title = The abstracts of the 26th congress of ESCTAIC, Timisoara, Romania, September 22–24 2016 date = 2017-03-07 pages = extension = .txt mime = text/plain words = 8628 sentences = 416 flesch = 44 summary = This is the reason why in the last decades a lot of clinical studies have been performed with the aim of reducing the magnitude of the postoperative pain, all of them directed to those factors which might influence the pain after surgery, such as: presence of preoperative chronic pain, anesthesia technique, or the need for an acute pain service. The list of proposals to be taken into consideration includes: a careful psychological evaluation and preparation of the surgical patient, a good preoperative sedation and even the use of antidepressants before surgery in specific cases. Regional anesthesia and ambulatory surgery: the role of continuous infusion devices in postoperative pain management in pediatrics Ralph J Beltran Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Columbus, OH, USA Continuous infusions of local anesthetic delivered via peripheral nerve block catheters (PNB) for postoperative pain management in adult patients has become more prevalent. cache = ./cache/cord-006563-qmigctkp.txt txt = ./txt/cord-006563-qmigctkp.txt === reduce.pl bib === id = cord-006226-fn7zlutj author = nan title = Abstracts of the 4th annual meeting of the German Society of Clinical Pharmacology and Therapy: Hannover, 14–17 September 1994 date = 1994 pages = extension = .txt mime = text/plain words = 25050 sentences = 1344 flesch = 50 summary = The following were analysed: heart rate (HR, bpm), pre-ejection time (PEP, ms), ejection time (VET, ms), HR-corrected electromechanical systole (QS2c, ms), impedance-cardiographic estimates of stroke volume (SV, ml), cardiac output (CO, I/min) and peripheral resistance (TPR, dyn.s.cm -5) calculated from CO and mean blood pressure (SBP and DBP according to auscultatory Korotkoff-I and -IV sounds This indicates that 1) about half the rise of HR and CO and half the shortening of PEP is 131-respectively 1~2-determined, 2) that predominant 132-adrenergic responses, whilst not affecting VET, take optimal benefit from the inodilatory enhancement of pump performance, 3) that an additional 131-adrenergic stimulation is proportionally less efficient, as VET is dramatically shortened, thus blunting the gain in SV so that the rise in CO relies substantially on the amplified increase of HR and 4), VET is more sensitive than QS2c in expressing additional 131-adrenoceptor agonism and 5) prime systolic time intervals provide a less speculative and physiologically more meaningful represenation of cardiac pump dynamics than HR-corrected ones. cache = ./cache/cord-006226-fn7zlutj.txt txt = ./txt/cord-006226-fn7zlutj.txt === reduce.pl bib === id = cord-006344-de4dhv4b author = Seitsonen, E. title = Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date = 2006-03-21 pages = extension = .txt mime = text/plain words = 2771 sentences = 174 flesch = 48 summary = title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection Reported here are two cases of hantavirus pulmonary syndrome caused by Puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. We describe two cases of PUU-associated HPS, in which administration of intravenous corticosteroids combined with continuous veno-venous hemodiafiltration (CVVHDF) was followed by rapid clinical improvement. On day 5 POS the lung infiltrates had increased considerably (Fig. 3a,b) , and the patient required continuous ventilation with a positive airway pressure mask. We describe two cases of PUU-infected patients who presented with both renal and respiratory failure requiring renal replacement therapy and mechanical ventilation. High levels of cytokineproducing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome High levels of viremia in patients with the Hantavirus pulmonary syndrome cache = ./cache/cord-006344-de4dhv4b.txt txt = ./txt/cord-006344-de4dhv4b.txt === reduce.pl bib === id = cord-005816-i54q5gsu author = nan title = 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date = 2009-08-06 pages = extension = .txt mime = text/plain words = 83124 sentences = 5617 flesch = 53 summary = Several factors such as the initial lack of symptoms, a low diagnostic sensitivity of the CT (34% false negatives), and the nonoperative management of solid organ injuries, have contributed to a delayed diagnosis in one of every five patients in our series, but this has not led to a significant increase in septic complications in this group. Method: The demographic features, the treatments, the intensity of the illness and mortality rate of the 155 patients in Afyon Kocatepe University General Surgery clinic between the years 2006 Background: Enterocutaneous fistula continues to be a serious surgical problem. Introduction: In our previous study, we examined the treatment results of burn patients older than 45 years, and found a significant increase in mortality with increasing age groups. Methods: Data on emergency surgical cases and admissions to the surgical service over a 3-month period were collected and analyzed; this included patient demographics, referral sources, diagnosis, operation, and length of stay (LOS Conclusion: Emergency workload represents a significant part of the work for the general surgeons. cache = ./cache/cord-005816-i54q5gsu.txt txt = ./txt/cord-005816-i54q5gsu.txt === reduce.pl bib === id = cord-006701-q8qh1kas author = Sadeghi, Behnam title = Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells date = 2019-12-18 pages = extension = .txt mime = text/plain words = 2343 sentences = 159 flesch = 56 summary = We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. The second patient was a 34-year old woman who was admitted 8 months after allogeneic hematopoietic stem cell transplantation due to hemolysis, impaired sensorium below arcus, and difficulty in ambulation. We have used placenta-derived decidua stromal cells (DSCs) for acute and chronic GVHD, ARDS and hemorrhagic cystitis [8] [9] [10] [11] . Electrophysiological investigation following DSCs infusion showed some improvement with more frequent motor unit activity, especially in the right arm. The day after the DSC infusion, she had normal sensation on neurological examination and subjectively in the lower abdomen and legs. The patient was examined with TMS and SEPs every 3-5 months up to a year after the onset of neurological symptoms. Placenta-derived decidua stromal cells for treatment of severe acute graft-versus-host disease cache = ./cache/cord-006701-q8qh1kas.txt txt = ./txt/cord-006701-q8qh1kas.txt === reduce.pl bib === id = cord-000083-3p81yr4n author = nan title = Poster Exhibition date = 2009-01-31 pages = extension = .txt mime = text/plain words = 112815 sentences = 7542 flesch = 56 summary = R. China Background: The objective of this study was to evaluate the early virologic response for prediction of achievement of HBeAg seroconversion and hepatitis B virus (HBV) DNA negativity after two years of lamivudine treatment in chronic hepatitis B (CHB) patients. Methods: A total of 620 patients who tested positive for hepatitis B surface antigen and were referred to Chiba University Hospital between February 1985 and March 2008 were included in the study, and their following characteristics were analyzed: age, gender, the status of HBeAg, ALT, HBV-DNA level, and PLT. Methods: A total of 60 patients with chronic hepatitis B, 32 (53.3%) were HBeAg positive (group A) while 28(46.7%) were HBeAg negative (group B) were included in this study after meeting the following criteria: age 18 to 60 years, HBsAg positive for more than 6 months, serum HBV-DNA was >5 log(10) copies/mL and ALT more than two times the upper normal limit. cache = ./cache/cord-000083-3p81yr4n.txt txt = ./txt/cord-000083-3p81yr4n.txt === reduce.pl bib === id = cord-006426-baf2d47y author = Kimura, Fumio title = Immunosuppression following surgical and traumatic injury date = 2010-08-26 pages = extension = .txt mime = text/plain words = 9852 sentences = 569 flesch = 37 summary = Suppression of cell-mediated immunity may be caused by multifaceted cytokine/inhibitor profiles in the circulation and other compartments of the host, excessive activation and dysregulated recruitment of polymorphonuclear neutrophils, induction of alternatively activated or regulatory macrophages that have anti-inflammatory properties, a shift in the T-helper (Th)1/Th2 balance toward Th2, appearance of regulatory T cells, which are potent suppressors of the innate and adaptive immune system, and lymphocyte apoptosis in patients with sepsis. 13, 14 In response to major tissue injury and/or bacterial infection, endothelial and epithelial cells, as well as neutrophils, macrophages, and lymphocytes, produce powerful proinfl ammatory cytokines, especially tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6. cache = ./cache/cord-006426-baf2d47y.txt txt = ./txt/cord-006426-baf2d47y.txt === reduce.pl bib === id = cord-005777-6rvfsx4p author = nan title = PS 0420-0716 date = 2007-08-25 pages = extension = .txt mime = text/plain words = 59217 sentences = 3634 flesch = 53 summary = We prospectively recorded data of all patients who were newly diagnosed with AF and all those with a septic shock on a surgical ICU (no cardiac surgery) during a one year period according to the requirements of the local ethical committee. Our aim was to evaluate the predictive role of admission APACHE II, admission and total maximum SOFA score, hypoalbuminemia, increased serum creatinine, C-reactive protein, lactate, and serum blood glucose for the 30-day mortality of septic patients admitted to medical ICU. The aim of this study was to analyze the clinical presentation and to evaluate mortality associated factors (timing and accurancy of diagnosis, timing of surgery, severity score and organ failure, surgical and medical treatments). Data were extracted independently to assess intention to treat intensive care unit (ICU) and hospital mortality, days of mechanical ventilation, length of stay, incidence of ventilator-associated pneumonia and pneumothorax, and associated complications of the implemented intervention. cache = ./cache/cord-005777-6rvfsx4p.txt txt = ./txt/cord-005777-6rvfsx4p.txt === reduce.pl bib === id = cord-006363-xov4xwpa author = Lu, Gen title = Study of Acute Exogenous Lipoid Pneumonia date = 2016-01-29 pages = extension = .txt mime = text/plain words = 3098 sentences = 161 flesch = 44 summary = OBJECTIVE: To analyze the clinical and imagenological characteristics of acute Exogenous lipoid pneumonia (ELP), explore its risk factors, and assess the potential role of multiple bronchoalveolar lavages (BALs) and steroid therapy in the treatment of children with acute ELP. Exogenous lipoid pneumonia (ELP) is a rare condition resulting from aspiration or inhalation of oil-based substances, with both acute and chronic forms. All patients satisfied the following diagnostic criteria: clinical presentation of acute respiratory or febrile illness combined with either radiological features diagnostic of lipoid pneumonia, or confirmation of the exogenous origin of the lipid through BAL. For each patient, the authors collected demographic data, clinical presentation, imagenological characteristics, categories of oil ingested, laboratory data, treatment, therapy response, BAL findings, and outcomes. The index study demonstrates that multiple BALs combined with steroid therapy result in significant improvement of clinical, radiologic and laboratory parameters in children with acute ELP. cache = ./cache/cord-006363-xov4xwpa.txt txt = ./txt/cord-006363-xov4xwpa.txt === reduce.pl bib === id = cord-006714-q7wy76e2 author = Delannoy, P.-Y. title = Impact of combination therapy with aminoglycosides on the outcome of ICU-acquired bacteraemias date = 2012-02-15 pages = extension = .txt mime = text/plain words = 2878 sentences = 173 flesch = 43 summary = Our study supports the hypothesis that combination short-term antibiotherapy with an aminoglycoside for ICU-acquired bacteraemias could increase survival. Meta-analysis failed to demonstrate improved outcomes in patients treated with antibiotic combinations over those receiving monotherapy [1] [2] [3] [4] and resulted in a decreased use of combination therapy. We performed a retrospective study to evaluate the impact of AGs in antimicrobial combination on ICU-acquired bacteraemia in our universityaffiliated ICU [8] [9] [10] [11] . The aim of the study was to evaluate the impact of AGs in antibiotic combination on the outcome of patients with ICU-acquired bacteraemia. We found a survival benefit with the use of combination therapy with AGs for ICU-acquired bacteraemias. In the ICU, inadequate empirical antibiotic therapy is associated with an increased mortality risk in patients with ventilator-associated pneumonia and bacteraemia. Our study suggests that short-term combination beta-lactams plus AGs therapy in intensive care unit (ICU)-acquired bacteraemia could reduce mortality. cache = ./cache/cord-006714-q7wy76e2.txt txt = ./txt/cord-006714-q7wy76e2.txt === reduce.pl bib === id = cord-006508-rje9bnph author = Ballas, Samir K. title = Sickle Cell Anaemia: Progress in Pathogenesis and Treatment date = 2012-10-10 pages = extension = .txt mime = text/plain words = 14697 sentences = 848 flesch = 49 summary = Lack of understanding of the nature and pathophysiology of the pain associated with sickle cell anaemia hampered rational approaches of therapy and had an adverse effect on the quality of life of an already compromised health status of affected patients. Beneficial effects of hydroxyurea in patients with sickle cell anaemia Decreases the frequency of acute painful episodes Decreases the incidence of acute chest syndrome Decreases the blood transfusion requirement Decreases morbidity and mortality error where a change of one letter of a keyword of a manuscript ('punctuation mutation') corrupts the meaning of the intended message. [48] These include: (i) the risk associated with the inhibiting effect of MAb 73E on platelet function with an unpredictable net clinical effect (i.e. thrombosis versus bleeding); and (ii) to be effective, these antibodies have to be administered before the RBC adhere to the vessel wall (i.e., pre-treatment before the onset of a vaso-occlusive event) a scenario that is unpredictable in patients with sickle cell anaemia. cache = ./cache/cord-006508-rje9bnph.txt txt = ./txt/cord-006508-rje9bnph.txt === reduce.pl bib === id = cord-006856-b1w25ob5 author = nan title = 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date = 2005 pages = extension = .txt mime = text/plain words = 29625 sentences = 1983 flesch = 52 summary = Egr-1 and hypoxia-inducible factor-1 (HIF-1) gene expression was examined in left ventricular biopsies of explanted failing hearts in 28 ICM and 42 DCM patients, as well as in 12 donor grafts before reperfusion (control), at 10, 30, 60 minutes after reperfusion, and at 1, 2, 3, 4, 6, 12 posttransplant weeks, using real-time RT-PCR. The risk of transplant-related mortality (TRM) due to graft-versushost disease (GvHD) is higher in male recipients of female stem cells compared with female patients receiving a graft from a female donor. We therefore analyzed a single-center cohort of 72 high-risk patients transplanted with a related or unrelated stem cell graft after nonmyeloablative conditioning for outcome (acute and chronic GvHD, TRM, relapse, and survival). Four patients between the age of 34 and 44 years underwent allogeneic peripheral blood stem cell (PBSC) transplantation (SCT) from HLA-identical sibling or unrelated donors at our institution. cache = ./cache/cord-006856-b1w25ob5.txt txt = ./txt/cord-006856-b1w25ob5.txt === reduce.pl bib === id = cord-007575-5ekgabx5 author = Luby, James P. title = Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses date = 2016-01-14 pages = extension = .txt mime = text/plain words = 11991 sentences = 735 flesch = 39 summary = Important trends and developments in the field include (1) the emergence of a Chlamydia psittaci strain (TWAR) that is passaged from human to human, causes a mycoplasma-like illness, and that is relatively resistant to erythromycin, (2) the recognition of respiratory syncytial virus as a pathogen in nursing home outbreaks and in immunosuppressed adults, (3) the continuing high lethality of fully developed influenza pneumonia, (4) the efficacy of acyclovir and adenine arabinoside in limiting the complications of varicella-zoster virus infections, and (5) the increasing frequency of pneumonia caused by cytomegalovirus and the severity of this disorder in highly immunosuppressed patients. Important trends and developments in the field include (1) the emergence of a Chlamydia psittaci strain (TWAR) that is passaged from human to human, causes a mycoplasma-like illness, and that is relatively resistant to erythromycin, (2) the recognition of respiratory syncytial virus as a pathogen in nursing home outbreaks and in immunosuppressed adults, (3) the continuing high lethality of fully developed influenza pneumonia, (4) the efficacy of acyclovir and adenine arabinoside in limiting the complications of varicella-zoster virus infections, and (5) the increasing frequency of pneumonia caused by cytomegalovirus and the severity of this disorder in highly immunosuppressed patients. cache = ./cache/cord-007575-5ekgabx5.txt txt = ./txt/cord-007575-5ekgabx5.txt === reduce.pl bib === id = cord-006464-s8rjoyse author = Bauer, Michael title = Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome date = 2015-02-27 pages = extension = .txt mime = text/plain words = 5413 sentences = 279 flesch = 44 summary = Our data for the first time show systematically that increased susceptibility to infections in MECP2 duplication syndrome is associated with IgA/IgG(2)-deficiency, low antibody titers against pneumococci and elevated acute-phase responses. The single patient who has to date not developed severe infections despite We further investigated whether patients with MECP2 duplication syndrome showed stronger acute phase responses, which we could confirm in 7/10 patients in terms of elevated CRP values above 200 mg/l during non-invasive infections, mainly pneumoniae. In summary we here show for the first time systematically that patients with MECP2 duplication syndrome are at increased risk for in particular non-invasive but also for invasive infections with potentially encapsulated bacteria, that this increased susceptibility to infections may be associated with IgG 2 -subclass deficiency/ low titers against pneumococci and elevated acute-phase responses, while the precise role of T-cell immunity and in particular the extent of impaired IFNγsecretion and its role for the observed infectious phenotype is still to be defined. cache = ./cache/cord-006464-s8rjoyse.txt txt = ./txt/cord-006464-s8rjoyse.txt === reduce.pl bib === id = cord-006517-845w9r6l author = Lalueza, A. title = Impact of severe hematological abnormalities in the outcome of hospitalized patients with influenza virus infection date = 2017-05-13 pages = extension = .txt mime = text/plain words = 4068 sentences = 209 flesch = 45 summary = The aim of the present study was to assess the frequency and clinical impact of hematological abnormalities in the range of those accepted by the Histyocite Society for the suspicion of HPS [19] in patients who were admitted to the hospital with a confirmed influenza virus infection. In Beutel's study of 25 critically ill patients with influenza A (H1N1) pdm09 virus associated hemophagocytic syndrome, the absence of steroid therapy in the early phase of the infection might have contributed to the high incidence of HPS (9 out of 25 patients) and the rather poor outcomes [18] . Significant hematological abnormalities are frequently seen in patients with influenza virus infection who required hospital admission and are associated with a poor outcome. cache = ./cache/cord-006517-845w9r6l.txt txt = ./txt/cord-006517-845w9r6l.txt === reduce.pl bib === id = cord-006768-r2pa9qw0 author = Shobha, Vineeta title = Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India date = 2018-02-28 pages = extension = .txt mime = text/plain words = 3088 sentences = 206 flesch = 51 summary = Patients who fulfilled any two of the four criteria proposed by the American College of Rheumatology, and those with clinical features of GPA with ANCA positivity and histopathological confirmation, were included in the study. Though we have sufficient information on the initial clinical presentations, the variable manifestations due to its multisystem involvement often delay the early diagnosis and treatment of this potentially treatable vasculitis. Considering the morbidity and mortality of this progressive vasculitis, knowledge of the various modes of presentation in various geographic regions is the key to early diagnosis and treatment. Clinical presentation as RPGN (28/38-66%) of those with renal GPA was the most common manifestation with 45% of Upper and lower respiratory involvement was seen in 63% of the patients which was much lower than the series from western and Asian data [12, 14, 15] . Wegener's granulomatosis in India: clinical features, treatment and outcome of twenty five patients cache = ./cache/cord-006768-r2pa9qw0.txt txt = ./txt/cord-006768-r2pa9qw0.txt === reduce.pl bib === id = cord-007444-c9vu8ako author = Sherk, Peter A. title = The Chronic Obstructive Pulmonary Disease Exacerbation date = 2000-12-01 pages = extension = .txt mime = text/plain words = 9154 sentences = 479 flesch = 40 summary = The three major bacterial pathogens isolated from patients with COPD during periods of both clinical stability and exacerbation are nontypeable Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella cafar~halis.~~ When FEV, is severely reduced, Enterobacteriaceae and Pseudomonas aeruginosa are also commonly detected.42 These organisms possess a wide array of virulence factors that allow them to evade clearance from the lower airways. Two randomized controlled trials evaluating the vaccine's efficacy among patients with COPD were unable to show statistically significant protective benefit.36, 69 A recent meta-analysis concluded that the vaccine provides partial protection against bacteremic pneumococcal pneumonia but not against other important outcomes, including bronchitis or mortality caused by pneumococcal infection. The dose of methylprednisolone was high (125 mg every 6 hours for 3 days) and resulted in significantly more hyperglycemia and, possibly, increased secondary infection rates.'06 In summary, the evidence from randomized, controlled trials supports the conclusion that among patients with acute exacerbations, oral or intravenous corticosteroids significantly increase the FEV, for up to 72 hours and likely reduce the risk for treatment failure. cache = ./cache/cord-007444-c9vu8ako.txt txt = ./txt/cord-007444-c9vu8ako.txt === reduce.pl bib === id = cord-007567-vst954ef author = Farquharson, Carolyn title = Responding to the severe acute respiratory syndrome (SARS) outbreak: Lessons learned in a Toronto emergency department() date = 2003-06-04 pages = extension = .txt mime = text/plain words = 4228 sentences = 234 flesch = 57 summary = 3 Epidemiologic evidence indicates that transmission of the illness occurs with close person-toperson contact (to household members, health care workers, or nearby patients who were not protected by contact or respiratory isolation precautions) and through droplet secretions. In an effort to deal with the transmission and onset of illness within health care and community settings, the province of Ontario designated a Provincial Operations Centre (POC), which was responsible for issuing directives to hospitals about patient care and infection control practices. Some had normal chest radiography with no infiltrates demonstrated (yet) but had symptoms of fever, headache, myalgia, and malaise, and 1 of 3 distinct exposures: they had either traveled to Vietnam, China, Hong Kong, Singapore, or Taiwan; they had been exposed to a person with SARS; or they had been a health care worker, patient, or visitor in a hospital in the GTA where there had been recorded cases of SARS transmission. cache = ./cache/cord-007567-vst954ef.txt txt = ./txt/cord-007567-vst954ef.txt === reduce.pl bib === id = cord-006444-eq56zhtd author = nan title = Abstracts of oral presentations and posters date = 1993 pages = extension = .txt mime = text/plain words = 40668 sentences = 2121 flesch = 53 summary = The results from ongoing preclinical studies continue to confirm the broad spectrum of biological activities possessed by rhiL-1 1 in vitro and suggest this cytokine may be an effective agent in the treatment of myelosuppression associated with cancer chemotherapy and bone marrow transplantation. We performed a phase H trial to assess the ability of G-CSF -mobilized PBPC to rapidly and completely restore hemopeiesis after high dose chemotherapy in the absence of bone marrow infusions, with selection for PBPC-only infusions based on yield of granulocyte -macrophage colony -forming cells (GM-CFC) after G-CSF treatment. Our approach for high-dose (HD) chemotherapy is to first treat patients eligible for dose intensification with a standard dose chemotherapy (VIP: VP26 = etoposide: 500 mg/m 2, ifosfamide: 4 g/m 2, cis-platinum: 50 mg/m 2) followed by the application of colony stimulating factors (G-CSF, GM-CSF or IL-3 + GM-CSF) in order to combine a regimen with broad anti-tumor activity with the recruitment of peripheral blood progenitor cells (PBPCs). cache = ./cache/cord-006444-eq56zhtd.txt txt = ./txt/cord-006444-eq56zhtd.txt === reduce.pl bib === id = cord-006862-5va1yyit author = nan title = ITS ASM 2012 date = 2012-11-04 pages = extension = .txt mime = text/plain words = 25959 sentences = 1689 flesch = 52 summary = 10 .45 % (n = 202) of attendances were for non-respiratory diseases as the clinic also provides follow-up for general medical patients post hospital admission. Higher levels of exercise participation were seen in the younger age groups (p = 0.585 Introduction: Respiratory diseases, largely represented by COPD, are the third most common cause of acute hospital admission.Our aim was to audit the prescribing habits of inhaled, nebulised medication and oxygen by doctors in a general hospital. Our study was designed to determine the baseline and post-treatment values of total lymphocyte count and its subsets in HIV-negative patients diagnosed with active pulmonary MTB. The results of this study indicate that AAT can inhibit LTB 4 signaling thereby reducing the proteolytic activity of neutrophils and propose AAT aerosolized augmentation therapy as an effective treatment for LTB 4 associated pulmonary diseases including cystic fibrosis and severe asthma. cache = ./cache/cord-006862-5va1yyit.txt txt = ./txt/cord-006862-5va1yyit.txt === reduce.pl bib === id = cord-006595-brpngt14 author = Pecchi, A. title = Radiologic imaging of the transplanted bowel date = 2005-03-04 pages = extension = .txt mime = text/plain words = 6147 sentences = 257 flesch = 37 summary = After sampling a loop easily accessible sonographically, axial and longitudinal US were views were scanned to evaluate the morphology, thickness, and echo structural features of the intestinal loops and color Doppler views of the superior mesenteric artery and wall arteriole of the sampled loop CT was performed with a multidetector scanner (General Electric Medical Systems) 2 to 4 weeks after surgery to evaluate the anatomy of the transplanted organs and arterial and venous anastomoses, complications previously identified with other methods or suspected, and periodically in the follow-up of patients who underwent transplantation due to Gardner syndrome. Traditional radiologic evaluation of the gastrointestinal tract with radiopaque contrast agent allowed anatomic and morphologic examinations of the graft, proximal and distal anastomoses, and tone and motility of transplanted loops in all patients (Fig. 1 ). cache = ./cache/cord-006595-brpngt14.txt txt = ./txt/cord-006595-brpngt14.txt === reduce.pl bib === id = cord-006864-t5qsjyfi author = Norris, S. title = National scientific medical meeting 1995 abstracts: Oral presentations date = 1995 pages = extension = .txt mime = text/plain words = 36469 sentences = 2072 flesch = 53 summary = 28 patients with RA were studied prospectively by measuring disease activity and radiological articular destruction at entry and at review 6 (mean) (range 4-8) years later. We document its occurrence in the paediatric age group with 3 case reports of tinea unguium occurring in healthy children, ages ranging from 7 to 14 years from different families, presenting over a 6 month period. The first group (the study group, n=20) consisted of patients attending ophthalmic clinics with a diagnosis of early open angle glaucoma who are on medical treatment with good control of intraocular pressure, evidence of optic disc cupping and no field loss on KOWA fields. In this study, 12 outpatients having Dementia of the Alzheimer Type (Clinical Dementia Rating, Score ~ 1 ; mean age _+ SEM, 74 + 2 years) were continuously monitored using Finapress and their responses to the Valsalva manoeuvre and positional change were compared with 12 age matched (73 _+ 1 years) healthy elderly controls. cache = ./cache/cord-006864-t5qsjyfi.txt txt = ./txt/cord-006864-t5qsjyfi.txt === reduce.pl bib === id = cord-006460-3ayc0hne author = Baue, Arthur E. title = Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients date = 2000-10-19 pages = extension = .txt mime = text/plain words = 8379 sentences = 558 flesch = 56 summary = Here, then, is an example of a Nobel Prize being awarded for the study of endothelial A.E. Baue ( ✉ ) cell-produced NO on the one hand, and the concept of excess vasodilatation in septic shock, the hypothesis that this was due to NO and a clinical trial blocking NO that increased mortality on the other. 3. We have tried to lump together and treat human abnormalities according to symptoms and signs rather than to the basic causes of their diseases -we have tried to treat inflammation, sepsis, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS) rather than what caused them; perforated diverticulitis is not acute pancreatitis and neither are ventilator-associated pneumonia and appendicitis. There has been significant improvement in survival of patients with persistent severe organ system failure." Thus, this report confirms again (1) that better intensive care is helping, and (2) my insistence that the secret to MOF is prevention. cache = ./cache/cord-006460-3ayc0hne.txt txt = ./txt/cord-006460-3ayc0hne.txt === reduce.pl bib === id = cord-007321-7gi6xrci author = Chow, Anthony W. title = Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections date = 1992-11-17 pages = extension = .txt mime = text/plain words = 16053 sentences = 825 flesch = 31 summary = These guidelines for the evaluation of drugs for the treatment of respiratory tract infections include acute streptococcal pharyngitis and tonsillitis, acute otitis media, acute and chronic sinusitis, acute exacerbations of chronic bronchitis, and acute infectious pneumonia (table 1). This is often the case in otitis media, sinusitis, and pneumonia, when the use of invasive procedures such as tympanocentesis, sinus puncture, or transtracheal aspiration to confirm microbial eradication in the patient who is improving clinically generally is considered unjustified. Patients eligible for study entrance are children or adults with symptomatic pharyngitis or tonsillitis of acute onset clinically consistent with infection with group A I3-hemolytic streptococci and from whom group A (3-hemolytic streptococci have been isolated in cultures of throat -swab specimen or for whom a rapid screening test has indicated the presence of streptococci. cache = ./cache/cord-007321-7gi6xrci.txt txt = ./txt/cord-007321-7gi6xrci.txt === reduce.pl bib === id = cord-007009-4wbvdg1r author = Takahashi, Toru title = The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan date = 2014-03-15 pages = extension = .txt mime = text/plain words = 4686 sentences = 236 flesch = 47 summary = Severe fever with thrombocytopenia syndrome (SFTS), an infectious disease with a high case-fatality rate, is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic to central and northeastern parts of China [1, 2] . Vero cells were inoculated with RT-PCR-positive patient sera for virus isolation, cultured for 4-7 days, and examined for SFTSV antigen detection by indirect immunofluorescence assay (IFA) with a polyclonal antibody raised against SFTSV recombinant NP (rNP; rabbit anti-SFTSV rNP serum), which was produced as follows. Physicians were asked to volunteer information if they had treated patients who satisfied the following case definition: (1) fever of >38°C; (2) gastrointestinal tract symptoms, such as nausea, vomiting, abdominal pain, diarrhea, and melena; (3) thrombocytopenia, with <100 × 10 9 platelets/L; (4) leukopenia, with <4 × 10 9 white blood cells/L; (5) elevated levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase; (6) absence of other causes; and (7) death or admission to an intensive care unit because of the severity symptoms. Detection of severe fever with thrombocytopenia syndrome virus (SFTSV) RNA in the right cervical lymph node by the in situ hybridization ATtailing method. cache = ./cache/cord-007009-4wbvdg1r.txt txt = ./txt/cord-007009-4wbvdg1r.txt === reduce.pl bib === id = cord-006869-g2q1gpp0 author = nan title = Neurocritical Care Society 7th Annual Meeting date = 2009-10-08 pages = extension = .txt mime = text/plain words = 45395 sentences = 2661 flesch = 49 summary = This was a pilot study to compare the cerebral neurochemical changes in patients with traumatic brain injury (TBI) who underwent conventional blood glucose level (BGL) control and intensive BGL control with continuous titrated insulin. We studied 14 comatose SAH patients who underwent multimodality neuromonitoring with intracranial pressure (ICP), cerebral microdialysis, and brain tissue oxygen (PbtO 2 ) as part of their clinical care. We studied 46 consecutive comatose patients with subarachnoid or intracerebral hemorrhage, traumatic brain injury, or cardiac arrest who underwent cerebral microdialysis and intracranial pressure monitoring.Continuous insulin infusion was used to maintain target serum glucose levels of 80-120 mg/dl. This suggests that risk of cerebral vasospasm following traumatic brain injury is increased not only in subarachnoid hemorrhage, but also intraparenchymal hemorrhage, and that Rotterdam CT score may be a useful metric for assessing risk of csPTV in severe TBI patients. cache = ./cache/cord-006869-g2q1gpp0.txt txt = ./txt/cord-006869-g2q1gpp0.txt === reduce.pl bib === id = cord-007564-ljqrxjvv author = Leroy, O. title = 04 – Apport des explorations microbiologiques au diagnostic des infections des voies respiratoires basses date = 2006-11-13 pages = extension = .txt mime = text/plain words = 13542 sentences = 1229 flesch = 54 summary = Trentetrois examens directs et 46 Ces données montrent que l'examen direct et la culture de l'expectoration dès lors qu'ils sont correctement effectués chez un patient sans antibiothérapie sont fréquemment positifs au cours des PAC à pneumocoque les plus graves, c'est-à-dire bactériémiques. Ces données ne doivent pas toutefois faire perdre de vue, comme le souligne Pesola [37] que dans plus de 10 % des cas, les PAC ont une étiologie plurimicrobienne et qu'il n'est peut être pas raisonnable de focaliser l'antibiothérapie uniquement sur le pneumocoque en cas de test positif. À partir d'échantillons provenant du tractus respiratoire inférieur (expectoration, voire prélèvements endoscopiques) ou supérieur (prélèvement nasopharyngé), un certain nombre de techniques ont été mises au point pour le diagnostic des infections liées à des germes tels que Chlamydia pneumoniae, Mycoplasma pneumoniae ou Legionella spp. cache = ./cache/cord-007564-ljqrxjvv.txt txt = ./txt/cord-007564-ljqrxjvv.txt === reduce.pl bib === id = cord-006828-i88on326 author = nan title = Abstracts DGRh-Kongress 2013 date = 2013-09-15 pages = extension = .txt mime = text/plain words = 30772 sentences = 2576 flesch = 52 summary = Comparing gene expression profiles of yellow fever immunized individuals and active SLE patients it was possible to identify a "common" and an "autoimmune-specific" IFN signature. The inflammatory and profibrotic effects upon Aab stimulation in vitro, and their associations with clinical findings suggest a role for autoantibody-mediated activation of immune cells mediated through the AT1R and ETAR in the pathogenesis or even the onset of the disease. This study was aimed to investigate the humoral and cellular immune response to VZV including assessment of IgG-anti-VZV avidity and VZV-specific reactivity of lymphocytes in RA (n=56) or JIA patients (n=75) on different treatments, including biologic agents, such as anti-tumor-necrosis-factor(TNF)-alpha or anti-interleukin-6 (IL-6) receptor inhibition (tocilizumab), compared to 37 healthy adults (HA) and 41 children (HC). Production of cytokines by B cells in response to TLR9 stimulation inversely correlates with disease activity in SLE-patients cache = ./cache/cord-006828-i88on326.txt txt = ./txt/cord-006828-i88on326.txt === reduce.pl bib === id = cord-006702-ekf6mja9 author = nan title = Abstracts for the 17th IPNA Congress, Iguaçu, Brazil, September 2016: Oral Presentations date = 2016-08-17 pages = extension = .txt mime = text/plain words = 23229 sentences = 1404 flesch = 52 summary = After correction using the optimal linear regression, the variability of the measurements was examined using Bland-Altman plots Results: We studied 29 patients (17 male, 12 female) with a median age (SD) of 14.0 (3.4) years and eGFR 111 (17) Objectives: Mutations of the Pkhd1 gene cause autosomal recessive polycystic kidney disease (ARPKD). Objectives: To examine the characteristics, follow up and availability of long term outcome data in a cohort of New Zealand children with acute kidney injury (AKI) requiring renal replacement therapy (RRT) following cardiac surgery at Starship Hospital over a six-year period. Methods: Cohort study conducted from 2008-2012 of 57 female patients age 9-21 years recruited from 2 pediatric nephrology clinics with CKD (n=25), on dialysis (n=9), or status post kidney transplantation (n=23) who received the standard 3-dose vaccine series of the HPV vaccine. cache = ./cache/cord-006702-ekf6mja9.txt txt = ./txt/cord-006702-ekf6mja9.txt === reduce.pl bib === id = cord-000718-7whai7nr author = nan title = ESP Abstracts 2012 date = 2012-08-22 pages = extension = .txt mime = text/plain words = 166497 sentences = 12847 flesch = 49 summary = Method: We analyzed consecutive gastric cancer cases in terms of AMACR immunohistochemical expression and clinical/pathological characteristics and followed patients' postoperative history. Results: Histological, immunohistochemical and molecular examination revealed non-neoplastic lymphadenopathy with atypical paracortical T-cell hyperplasia with immunoblastic reaction in the former and burnt-out histiocytic pattern in the latter, both falling into a broad spectrum of reactive lymph node changes associated with Still's disease. Method: We have thus collected, from our two Institutions a large number (45 cases) of cancers showing the histological definition of adenosquamous carcinomas according to the WHO criteria and performed gene analysis for k-RAS (codons 12, 13) and EGFR (codons 18, 19 and 21) mutations. Objective: We previously identified amplified fibroblast growth factor 1 (FGFR1) as a therapeutic target for small molecule inhibitor (SMI) therapy in squamous cell lung cancer (L-SCC), resulting in currently running clinical trials treating patients with stage III disease. cache = ./cache/cord-000718-7whai7nr.txt txt = ./txt/cord-000718-7whai7nr.txt === reduce.pl bib === id = cord-005881-oswgjaxz author = nan title = Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date = 2010 pages = extension = .txt mime = text/plain words = 71955 sentences = 4561 flesch = 52 summary = Prospective case series with historical control group.(Level III) Results: Preliminary data indicate: *a shorter time on ventilator than anticipated (based on comparisson to historical data) * a shorter time on ICU * less pneumoniae * no intra-operative complications * good healing results of the rib fractures * no implant failures * acceptable pain scores * good overal satisfaction * acceptable cosmetic results Conclusion: Internal fixation of rib fractures (flair chest or multiple sequential fractures with pulmonary function compromise) results in a earlier recuperation of pulmonary function with shortened ICU stay. (Regional Association Sanitary Emergencies) Material and Methods: The ARES, whose members are about 600, all over the nation, is configured as an extraordinary health resource, activated by the National Civil Defence operations centre, in according with the Regional centre of Marche, in disater situations Results: The main objectives of ARES are training and organization of medical staff and structures and its growth crosses several missions including: AE Earthquake in Molise, 2002 Introduction: Cephalomedullary nails rely on a large lag screw that provides fixation into the femoral head. cache = ./cache/cord-005881-oswgjaxz.txt txt = ./txt/cord-005881-oswgjaxz.txt === reduce.pl bib === id = cord-007563-33jxxp1b author = nan title = Full Issue PDF date = 2018-06-25 pages = extension = .txt mime = text/plain words = 8282 sentences = 475 flesch = 46 summary = In the present study, we investigated titin-isoform expression, total-titin and site-specific N2Bus/PEVK phosphorylation, and the degree of fibrosis in endomyocardial biopsy samples from AS patients compared with nonfailing donor heart samples. In our patient group, we found a significant shift toward the more compliant N2BA titin isoform versus nonfailing donor heart samples ( Figure 2) . This GCH1-GFRP complex is operative in humans because oral challenge with L-phe leads to a 3-fold rise in plasma biopterin levels (a correlate of BH 4 )-an effect that is attenuated in patients with a loss-of-function GCH1 mutation (23 To support this hypothesis, it is known the GCH1-GFRP axis regulates BH 4 and NO in endothelial cells (25) . Some studies report that elevations in circulating biomarkers of oxidative stress (myeloperoxidase) precede clinically significant systolic dysfunction in anthracycline-treated patients (8, 15 CT images were used to localize the heart and confirm the epicardial surfaces for VOI edge placement. cache = ./cache/cord-007563-33jxxp1b.txt txt = ./txt/cord-007563-33jxxp1b.txt === reduce.pl bib === id = cord-006975-u5ecibta author = Haviland, Kelly title = Outcomes after long-term mechanical ventilation of cancer patients date = 2020-03-30 pages = extension = .txt mime = text/plain words = 3608 sentences = 183 flesch = 49 summary = The outcomes achieved by medical care of patients requiring mechanical ventilation have been incompletely characterized with regard to the likelihood of both weaning and survival, and even less so with regard to quality of life during the time these patients remain alive. To measure whether the creation of a dedicated weaning program altered the outcomes seen in this patient population, we performed a single-institution retrospective study of cancer patients requiring long-term mechanical ventilation who were cared for in a specialized intermediate care weaning unit. Design, setting, and eligibility criteria After a waiver of authorization (WA0023-13) was obtained from the Institutional Review Board at Memorial Sloan Kettering Cancer Center, we performed a retrospective review of a single institution's experience with all patients treated with prolonged mechanical ventilation with weaning as a goal of care after ICU discharge, subject to intensivist discretion, between 2008 and 2012 and between January and December 2018. cache = ./cache/cord-006975-u5ecibta.txt txt = ./txt/cord-006975-u5ecibta.txt === reduce.pl bib === id = cord-006882-t9w1cdr4 author = nan title = Royal Academy of Medicine in Ireland date = 2012-07-22 pages = extension = .txt mime = text/plain words = 13704 sentences = 858 flesch = 52 summary = Objective: The aim of this study was to develop a mathematical model to determine the TTO based on two or more DEXA scans with TTO defined as the age at which the patient will enter the osteoporotic T-score range. An Audit of Clinical Outcomes in Transcervical Resection of the Endometrium Compared to Outpatient Balloon Thermablation Anglim BC, Von Bunau G Department of Gynaecology, Adelaide and Meath Children's Hospital, Tallaght, Dublin Thermablation was introduced to the Coombe in November 2009 and thus far it has provided a quick and effective means of treating women with menorrhagia refractive to medical treatment. This audit reviewed cases of ovarian cystectomy, oopherectomy and salpingooopherectomy using both a hospital online database and records of theatre procedures to identify these patients. A retrospective review of the case notes of patients aged greater than 80 years who underwent bronchoscopy between September 2009 and November 2011 was carried out. cache = ./cache/cord-006882-t9w1cdr4.txt txt = ./txt/cord-006882-t9w1cdr4.txt === reduce.pl bib === id = cord-006888-qfnukav4 author = nan title = Irish Thoracic Society Annual Scientific Meeting, Ramada Hotel, Belfast: 7th–8th November 2008 date = 2008-10-21 pages = extension = .txt mime = text/plain words = 30369 sentences = 1866 flesch = 53 summary = 2 This study explored anxiety, depression and QoL of a small group of patients (n = 5), predominantly male (66.7%), mean age 74 years, using the Marie Curie ''breathing space'' outpatient clinic over a four week period. Methods: CF patients attending CUH completed a questionnaire relating to personal smoking and second-hand smoke (SHS) exposure, correlated with pulmonary function and exacerbation-rate data. This ongoing study indicates that a clinical pharmacy led management programme can reduce the need for hospital care in patients with moderate-to-severe COPD and improve aspects of their health related quality of life. There is a need for wider availability of joint hospital/ community based initiatives such as COPD Outreach and PRPs. Pulmonary rehabilitation has established efficacy, but patients often require follow-up care or maintenance. Patient data (MDS/ISWT/endurance shuttle walking test(ESWT)) from our pulmonary rehabilitation programme were initially analysed (n = 214; median FEV 1 = 1.04 L; mean age = 69 yrs). cache = ./cache/cord-006888-qfnukav4.txt txt = ./txt/cord-006888-qfnukav4.txt === reduce.pl bib === id = cord-007818-jfp9uumb author = Papali, Alfred title = Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings date = 2019-02-09 pages = extension = .txt mime = text/plain words = 15059 sentences = 654 flesch = 34 summary = Finally, so-called telemedicine in ICUs in resource-rich settings, mainly to solve the problem of physician shortages during nighttime hours and in some ICUs with low-intensity staffing [21] , has been shown to improve early identification of patients who deteriorate [22] and increases the number of interventions [23] , but the effect on ICU outcomes remains controversial [24] and costs of required technological infrastructure are high [25] . Despite the availability of specialty training programs in selected countries, regional data and the experience of the authors suggest that intensive care specialists are unavailable in many ICUs in resource-limited settings [40] . Dedicated courses in trauma and intensive care-and emergency medicine-related procedures improve knowledge in "best clinical practice" of healthcare professionals working in ICUs in resource-limited settings [56, 57] . cache = ./cache/cord-007818-jfp9uumb.txt txt = ./txt/cord-007818-jfp9uumb.txt === reduce.pl bib === id = cord-006924-1i3kf01j author = nan title = Abstracts from USCAP 2020: Pulmonary, Mediastinum, Pleura, and Peritoneum Pathology (1869-1980) date = 2020-03-05 pages = extension = .txt mime = text/plain words = 25334 sentences = 1479 flesch = 50 summary = Results: Patients' characteristics of 77 cases were as following; median age was 60 years old (range 33-77); 67 male and ten female; 16/16/41/4 of clinical Stage I/II/II/VI; 21 chemotherapy, 52 chemoradiation and 4 radiotherapy; 52 adenocarcinomas, 18 squamous cell carcinomas and seven other types of histology. The aim of this study was to explore the expression of piR-796 piRNA, which was identified by small RNAseq, in resected nonsmall cell lung cancer (NSCLC) patients, and to analyze the correlation with the clinic-pathological features. Conclusions: Our data demonstrated that OTP expression was only rarely identified in non-pulmonary neuroendocrine tumors/carcinomas, which further validated the previous report of OTP to be a highly specific marker for diagnosing PCs. The diagnostic sensitivity for PCs in this study appears to be lower than the previous report, which is probably due to the small number of cases included. cache = ./cache/cord-006924-1i3kf01j.txt txt = ./txt/cord-006924-1i3kf01j.txt === reduce.pl bib === id = cord-007786-cu831tl7 author = Dondorp, Arjen M. title = Management of Severe Malaria and Severe Dengue in Resource-Limited Settings date = 2019-02-09 pages = extension = .txt mime = text/plain words = 4114 sentences = 205 flesch = 43 summary = We suggest that in patients with hypotensive shock, fluid bolus therapy (30 mL/kg) with isotonic crystalloids be commenced (ungraded) and, if available, early initiation of vasopressor medication (ungraded) Timing of enteral feeding in cerebral malaria We suggest not to use a strategy of permissive hypercapnia to achieve ventilation with low tidal volumes in patients with cerebral malaria, because of the high incidence of brain swelling in these patients (ungraded) Fluid management in severe dengue We recommend not to use prophylactic platelet transfusion for thrombocytopenia in the absence of active bleeding complications or other risk factors (uncontrolled arterial hypertension, recent stroke, head trauma or surgery, continuation of an anticoagulant treatment, existing hemorrhagic diathesis) (1B) acidosis [14, 15] , and transpulmonary thermodilution-guided rapid fluid resuscitation resulted in pulmonary edema in 8/28 (29%) patients [15] . There are several randomized clinical trials comparing crystalloid with colloid fluid management for the treatment of patients with severe dengue and compensated shock. cache = ./cache/cord-007786-cu831tl7.txt txt = ./txt/cord-007786-cu831tl7.txt === reduce.pl bib === id = cord-008672-luoxomif author = Mwachari, C. title = Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya date = 2004-10-29 pages = extension = .txt mime = text/plain words = 3175 sentences = 194 flesch = 49 summary = We undertook a prospective cross-sectional study of adult patients admitted to a government hospital in Nairobi, Kenya, to determine possible bacterial, mycobacterial, parasitic and viral causes of diarrhoca; to consider which may be treatable; and to relate microbiological findings to clinical outcome. METHODS: Stool specimens from 75 consecutive HIV-seropositive patients with chronic diarrhoca admitted to a Nairobi hospital were subjected to microbiological investigation and results were compared with clinical findings and outcome. CONCLUSIONS: HIV-infected patients with chronic diarrhoea in Nairobi have a poor outcome overall, and even with extensive investigation a putative pathogen was identified in only just over half the patients. We undertook a 4-month study in Nairobi, Kenya, to determine possible bacterial, viral and parasitological causes of chronic diarrhoea and wasting using a broad range of investigations and related findings to patient outcome. cache = ./cache/cord-008672-luoxomif.txt txt = ./txt/cord-008672-luoxomif.txt === reduce.pl bib === id = cord-007833-wkv808ix author = Modi, Dipenkumar title = Pomalidomide-Induced Pulmonary Toxicity in Multiple Myeloma date = 2015-12-16 pages = extension = .txt mime = text/plain words = 1338 sentences = 101 flesch = 44 summary = In this article, the authors report an additional case of pomalidomide-induced pulmonary toxicity based on temporal relationship between drug administration and onset of symptoms as well as characteristic imaging findings. Lenalidomide and bortezomib were discontinued, and he was initiated on pomalidomide 4 mg/d, days 1 through 21 with dexamethasone 20 mg once weekly. Approximately 8 months after starting treatment with pomalidomide, the patient developed fever, progressive dyspnea, productive cough, and generalized weakness for 5 days duration before presenting to the hospital. The patient's recurrence and resolution of symptoms in a temporal relationship to therapy with pomalidomide, along with ground glass opacities on CT, led to a strong suspicion of pomalidomide-induced pulmonary toxicity. 3, 4 Pulmonary toxicity is an uncommon but increasingly reported clinical complication of IMiD agents, particularly thalidomide and lenalidomide. Usual time interval between initiation of treatment to onset of symptoms is 8 to 120 days, but toxicity from pomalidomide may be delayed. cache = ./cache/cord-007833-wkv808ix.txt txt = ./txt/cord-007833-wkv808ix.txt === reduce.pl bib === id = cord-007580-qwh8ei60 author = Knopf, Harry L.S. title = Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date = 2014-09-26 pages = extension = .txt mime = text/plain words = 5104 sentences = 320 flesch = 53 summary = We had three major goals: to determine the rate of viral recovery from cases of nonepidemic acute or subacute follicular conjunc tivitis; to compare the accuracy of clinical diagnoses with that achieved by culture or serologic studies, or both; and to explore the possible role of serum antibody in the forma tion and maintenance of corneal subepithelial infiltrates. 4 VIRAL KERATOCONJUNCTIVITIS 663 antibody titers to vaccinia, herpes, coxsackievirus A-9, A-16, and A-21, and four strains of acute hemorrhagic conjunctivitis virus were similarly assayed by serum neutraliza tion tests in human diploid fibroblast tissue culture. Table 2* shows the difference between the number of positive isolates ob tained by culturing before or after the eighth * All of the data for the epidemic keratoconjunc tivitis group were published elsewhere, except for the corneal quantitative material in clinical studies.' day of illness. cache = ./cache/cord-007580-qwh8ei60.txt txt = ./txt/cord-007580-qwh8ei60.txt === reduce.pl bib === id = cord-000977-ka4261wc author = nan title = ECR 2013 Book of Abstracts - B - Scientific Sessions date = 2013-03-07 pages = extension = .txt mime = text/plain words = 132895 sentences = 8080 flesch = 50 summary = Methods and Materials: Mean attenuation, contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) at abdominal aorta, right renal artery (RRA) and left renal artery (LRA) were measured in 24 kidney donors who had undergone CTA with tube current modulation, 120 kVp, filtered back projection reconstruction algorithm (Group A) and were compared with 24 BMI-matched kidney donors who had undergone CTA with automated kVp selection and SAFIRE (Group B Purpose: Cerebral small vessel disease (SVD) is a common cause of cognitive impairment. Overall average score of SSF reconstructed segments was significantly higher compared with STD reconstruction ( Purpose: To evaluate the feasibility and imaging quality of double prospectively ECG-triggered high-pitch spiral acquisition mode for coronary computed tomography angiography (CTCA) in patients with atrial fibrillation (AF). cache = ./cache/cord-000977-ka4261wc.txt txt = ./txt/cord-000977-ka4261wc.txt === reduce.pl bib === id = cord-007696-83v9yfa6 author = Zisman, David A. title = Pulmonary Fibrosis date = 2005 pages = extension = .txt mime = text/plain words = 13991 sentences = 691 flesch = 40 summary = Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease limited to the lungs and associated with the histologic appearance of usual interstitial pneumonia (UIP) on surgical lung biopsy. Factors that predict poor outcome include older age, male gender, severe dyspnea, history of cigarette smoking, severe loss of lung function, appearance and severity of fibrosis on radiological studies, lack of response to therapy, and prominent fibroblastic foci on histopathologic evaluation. With greater comprehension of the clinical relevance of the different histopathological subgroups that make up the idiopathic interstitial pneumonias, the term idiopathic pulmonary fibrosis (IPF) is now reserved to patients with idiopathic usual interstitial pneumonia (UIP) on surgical lung biopsy. Tang In a recent study, human T-lymphtropic virus type I (HTVL-I) positive IPF patients had more affected lung parenchyma, demonstrated traction bronchiectasis with honeycomb change, and exhibited increased levels of specific cytokines that correlated with activated T-cells in the bronchoalveolar lavage fluid (BALF). cache = ./cache/cord-007696-83v9yfa6.txt txt = ./txt/cord-007696-83v9yfa6.txt === reduce.pl bib === id = cord-007788-09t52zix author = Wallhult, Elisabeth title = Early and Acute Complications and the Principles of HSCT Nursing Care date = 2017-11-22 pages = extension = .txt mime = text/plain words = 13962 sentences = 766 flesch = 46 summary = Some other relatively rare complications are also covered here: haemorrhagic cystitis (HC), endothelial damage (ED) syndromes including engraftment syndrome (ES), idiopathic pneumonia syndrome (IPS), diffuse alveolar haemorrhage (DAH), transplant-associated microangiopathy (TAM) and sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). Oral damage may be a hallmark of graft versus host disease (GvHD) in patients following allogeneic stem cell transplantation, and the presence of lichenoid hyperkeratotic plaques (diagnostic sign), gingivitis, mucositis, erythema, pain, xerostomia and ulcers may indicate GvHD. The increased risk of infections in patients undergoing haematopoietic stem cell transplantation (HSCT) is well known, and infection is a leading cause of morbidity and mortality. Differential diagnoses will need to be excluded by assessing risk factors, symptoms and lab tests since liver dysfunction can also be seen in sepsis, viral infection, graft versus host disease (GvHD) and iron overload and as a side effect from many of the drugs used in the HSCT setting. cache = ./cache/cord-007788-09t52zix.txt txt = ./txt/cord-007788-09t52zix.txt === reduce.pl bib === id = cord-007865-1oyl6clq author = Walsh, Paul title = Patients Would Prefer Ward to Emergency Department Boarding While Awaiting an Inpatient Bed date = 2008-02-21 pages = extension = .txt mime = text/plain words = 2437 sentences = 135 flesch = 58 summary = title: Patients Would Prefer Ward to Emergency Department Boarding While Awaiting an Inpatient Bed Boarding of admitted patients in the Emergency Department (ED), rather than in inpatient care areas, is widespread. The practice of holding admitted patients in the Emergency Department (ED) until an inpatient bed becomes available (commonly called "boarding") is widespread (1, 2) . These were convenience samples (dependent on research assistant [RA] availability) of 1) patients waiting to be seen without a disposition, 2) visitors of patients, and 3) admitted patients who were being held in the ED while awaiting an inpatient bed. The purpose of sampling these three groups was to determine the opinion of members of the general public with an immediate interest in the subject (visitors), non-boarding patients, and those patients who were actually being boarded in the ED. Emergency department overcrowding: patient preference for boarding hallway location cache = ./cache/cord-007865-1oyl6clq.txt txt = ./txt/cord-007865-1oyl6clq.txt === reduce.pl bib === === reduce.pl bib === id = cord-006880-9dgmdtj8 author = nan title = Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date = 2012-09-19 pages = extension = .txt mime = text/plain words = 82351 sentences = 4528 flesch = 49 summary = Patients initially comatose after cardiac arrest treated who awoke after therapeutic hypothermia (TH) were evaluated by a neuropsychologist prior to hospital discharge with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a well-validated tool that assesses function in multiple domains compared to standardized normal values. Clinical data including the pre-admission-status, neuroradiological, initial presentation, treatment, and outcome were evaluated through institutional databases, patient's medical charts and by mailed questionnaires. To determine the differences in hospital outcomes among adult mild traumatic brain injury (TBI) patients where the severity of TBI is defined by Glasgow Coma Scale (GCS) score. Retrospective chart analysis was performed on all adult patients arriving to emergency department with history of fall at a level one trauma center for parameters like vomiting, alteration of consciousness (AOC) & loss of consciousness (LOC) after TBI; post-traumatic amnesia (PTA) and history of seizures before or after injury, along with outcomes such as ICU admission & ICU length of stay. cache = ./cache/cord-006880-9dgmdtj8.txt txt = ./txt/cord-006880-9dgmdtj8.txt === reduce.pl bib === id = cord-007798-9ht7cqhu author = Smith, Silas W. title = Drugs and pharmaceuticals: management of intoxication and antidotes date = 2010-02-25 pages = extension = .txt mime = text/plain words = 22555 sentences = 1371 flesch = 34 summary = In the context of analgesic, anti-inflammatory, anticholinergic, anticonvulsant, antihyperglycemic, antimicrobial, antineoplastic, cardiovascular, opioid, or sedative-hypnotic agents overdose, N-acetylcysteine, physostigmine, l-carnitine, dextrose, octreotide, pyridoxine, dexrazoxane, leucovorin, glucarpidase, atropine, calcium, digoxin-specific antibody fragments, glucagon, high-dose insulin euglycemia therapy, lipid emulsion, magnesium, sodium bicarbonate, naloxone, and flumazenil are specifically reviewed. As might be anticipated from the fact that supportive care suffices for the majority of poisoned patients, a typical study of routine administration of charcoal following oral overdose of primarily benzodiazepines, acetaminophen, and selective serotonin reuptake inhibitors could not demonstrate benefit [16, 17, 23] . Patient characteristics suggesting extracorporeal therapy include signs or symptoms of significant end organ toxicity; impaired elimination secondary to baseline comorbidities or critical illness-induced hypoperfusion; inability to tolerate or refractory to antidotal strategies (such as bicarbonate or saline); inadequate response to supportive care measures; concurrent electrolyte derangements (e.g., metformin-associated lactic acidosis); or serum drug concentrations historically associated with severe outcome [127] . cache = ./cache/cord-007798-9ht7cqhu.txt txt = ./txt/cord-007798-9ht7cqhu.txt === reduce.pl bib === id = cord-006182-kck5e1ry author = nan title = 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date = 2019-10-01 pages = extension = .txt mime = text/plain words = 87645 sentences = 4817 flesch = 46 summary = The primary objective of COGiTATE (CppOpt GuIded Therapy Assessment of Target Effectiveness) is to demonstrate feasibility of individualising CPP at CPPopt in TBI patients, expressed as the percentage of monitoring time for which CPP is within 5 mmHg of regularly updated CPPopt targets during the first 5 days of Intensive Care Unit (ICU) admission. Neurocritical care has become increasingly subspecialized.Yet, due to limited availability of dedicated Neurocritical Care units (NCCUs), often patients may need to be admitted to ICUs other than NCCUs. This survey based study was conducted to explore self-reported knowledge in recognizing and managing some common neurological emergencies such as stroke, status epilepticus, raised intracranial pressure etc among critical care nurses at a Comprehensive Stroke Center. Coagulation factor Xa (recombinant), inactivated-Xa inhibitor associated life--factor prothrombin complex concentrate (PCC) was utilized offRetrospective, single center, cohort study including adult intracranial hemorrhage patients who received discharge between efficacy (defined by International Society on Thrombosis and Haemostasis criteria), thrombotic events, ICU and hospital length of stay, and mortality. cache = ./cache/cord-006182-kck5e1ry.txt txt = ./txt/cord-006182-kck5e1ry.txt === reduce.pl bib === id = cord-005727-li8pwigg author = nan title = ESICM 2010 MONDAY SESSIONS 11 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 102770 sentences = 6408 flesch = 53 summary = Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. cache = ./cache/cord-005727-li8pwigg.txt txt = ./txt/cord-005727-li8pwigg.txt === reduce.pl bib === id = cord-008596-zhk82cor author = Watts, Clark title = Erosion of physician autonomy and public respect for the profession() date = 2008-07-09 pages = extension = .txt mime = text/plain words = 3900 sentences = 193 flesch = 52 summary = The questions are "what happened?" and "why review this topic now?" In inverse order, I believe after the present presidential campaign, we will see major efforts to revise the structure of the US health care system, and the changes advocated will have significant impacts on physicians and the way they practice [4] . Belatedly, physicians began organizing their practices around the group model to overcome these concerns; belatedly, because the managed care model they were fighting began to lose acceptance by the public as it did not hold down costs, and its proactive policies regarding physician decision making were offensive to patients [15] . These changes in the US health care system, which have restricted physician autonomy, have also adversely affected the public's respect for the medical profession for one major reason. cache = ./cache/cord-008596-zhk82cor.txt txt = ./txt/cord-008596-zhk82cor.txt === reduce.pl bib === id = cord-009417-458rrhcm author = Luce, Judith A. title = Use of Blood Components in the Intensive Care Unit date = 2009-05-15 pages = extension = .txt mime = text/plain words = 17101 sentences = 918 flesch = 43 summary = Benefi ts to the patient with more judicious use of platelet transfusion include decreased donor exposure, which lessens the risk of transfusion-transmitted disease; fewer febrile and allergic reactions that may complicate the hospital course; and the potential delay or prevention of alloimmunization to HLA and platelet antigens. If anti-IgA antibodies are determined to be the cause of this reaction, the patient must receive blood components donated by IgA-defi cient individuals or, if unavailable, specially prepared washed RBCs and platelet concentrates. These patients may have intensive red cell and platelet transfusion requirements and need specialized products such as CMV-negative and irradiated blood components. A blood bank problem uniquely encountered in BMT is the need to switch the patient's ABO group because of an ABO-mismatched transplant, thus necessitating an exchange transfusion of red cells and plasma-containing products (i.e., platelet concentrates) of differing ABO type to avoid hemolysis of donor and recipient cells. cache = ./cache/cord-009417-458rrhcm.txt txt = ./txt/cord-009417-458rrhcm.txt === reduce.pl bib === id = cord-009285-1ddfywfa author = Assicot, M. title = High serum procalcitonin concentrations in patients with sepsis and infection date = 1993-02-27 pages = extension = .txt mime = text/plain words = 2593 sentences = 127 flesch = 40 summary = By means of a monoclonal immunoradiometric assay for calcitonin precursors, we have measured serum concentrations of procalcitonin in patients with various bacterial and viral infections. Lancet 1993; 341: 518-21 Introduction About 3000 of the 30 000 people admitted to hospital in the UK each year for acute upper-gastrointestinal-tract bleeding will die.1 Prognostic indicators for outcome include: age, pulse rate, blood pressure, and haemoglobin at admission, and findings at endoscopy, such as presence, site, and nature of a bleeding lesion, and stigmata of recent bleeding.2-4 One factor that may promote continued bleeding and hence an adverse clinical outcome is the fibrinolytic activity of the upper gastrointestinal tract, because fibrinolysis may lead to digestion of haemostatic plugs.5 Consistent with this possibility, Poller and colleaguess demonstrated increased serum fibrin degradation products (FDP) in a small series of patients with acute upper-gastrointestinal-tract bleeding; however, the prognostic value of serum FDP concentrations has not been reported in a prospective study. cache = ./cache/cord-009285-1ddfywfa.txt txt = ./txt/cord-009285-1ddfywfa.txt === reduce.pl bib === id = cord-009278-98ebmd33 author = Ferreira-Coimbra, João title = Burden of Community-Acquired Pneumonia and Unmet Clinical Needs date = 2020-02-18 pages = extension = .txt mime = text/plain words = 5567 sentences = 282 flesch = 39 summary = Community-acquired pneumonia (CAP) is the leading cause of death among infectious diseases and an important health problem, having considerable implications for healthcare systems worldwide. Recently, Nature Medicine published the first use of phages to treat a multidrug-resistant (MDR) microorganism [3] and Lancet Infectious Diseases reported the first use of pneumolysin in severe CAP treatment added to standard of care in a phase II trial [4] . Incidence of community-acquired lower respiratory tract infections and pneumonia among older adults in the United Kingdom: a population-based study Incidence rate of community-acquired pneumonia in adults: a population-based prospective active surveillance study in three cities in South America Disease burden and etiologic distribution of community-acquired pneumonia in adults: evolving epidemiology in the era of pneumococcal conjugate vaccines Epidemiology and clinical outcomes of community-acquired pneumonia in adult patients in Asian countries: a prospective study by the Asian network for surveillance of resistant pathogens Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial cache = ./cache/cord-009278-98ebmd33.txt txt = ./txt/cord-009278-98ebmd33.txt === reduce.pl bib === id = cord-008695-y7il3hyb author = nan title = Pandemic Flu: Clinical management of patients with an influenza-like illness during an influenza pandemic date = 2007-01-25 pages = extension = .txt mime = text/plain words = 25924 sentences = 1616 flesch = 46 summary = Children may be considered at increased risk of complications if they have cough and fever (or influenza-like illness) and temperature >38.5ºC, plus either chronic co-morbid disease or one of following features: breathing difficulties severe earache vomiting >24 hours drowsiness These patients should be offered an antibiotic as well as oseltamivir (in those >1 year of age) and advice on antipyretics and fluids. Children may be considered at increased risk of complications if they have: Cough and fever (or influenza-like illness) and temperature >38.5ºC and either (i) chronic co-morbid disease (see Appendix 2) or (ii) one of the following features • Breathing difficulties • Severe earache • Vomiting > 24 hours • Drowsiness These patients should be offered an antibiotic as well as oseltamivir (in those over one year of age) and advice on antipyretics and fluids. cache = ./cache/cord-008695-y7il3hyb.txt txt = ./txt/cord-008695-y7il3hyb.txt === reduce.pl bib === id = cord-009360-rgwe2pkx author = Pilatz, Adrian title = High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval date = 2019-08-27 pages = extension = .txt mime = text/plain words = 4284 sentences = 228 flesch = 36 summary = Considering infection/inflammation to be an important risk factor in male infertility, the aim of this study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients. Considering infection/inflammation to be an important risk factor in male infertility and the frequent presence of pathogens within the seminal tract, the aim of this prospective study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients undergoing testicular biopsy/TESE. To the best of our knowledge, this is the first prospective study which set out to comprehensively evaluate infection and inflammation in patients presenting with azoospermia using a 2-glass test and analysis of semen, testicular fluid and testicular tissue by measuring inflammatory parameters and performing systematic microbiological investigations. cache = ./cache/cord-009360-rgwe2pkx.txt txt = ./txt/cord-009360-rgwe2pkx.txt === reduce.pl bib === id = cord-009891-gqrhbhbn author = Rassool, G. Hussein title = Current issues and forthcoming events date = 2003-09-03 pages = extension = .txt mime = text/plain words = 3466 sentences = 168 flesch = 49 summary = The Centers for Disease Control and Prevention (CDC), USA, reports that 'transmission to health care workers appears to have occurred after close contact with symptomatic individuals (e.g. persons with fever or respiratory symptoms) before recommended infection control precautions for SARS were implemented (i.e. unprotected exposures).' There is also a possibility that the causative agent can remain viable for extended periods of time after drying on environmental surfaces. Preliminary results of a large-scale trial of a candidate AIDS vaccine announced by the US-based biotechnology company VaxGen suggest that it is possible to protect some individuals from HIV infection. The result is that poor diagnosis of pain in cancer patients remains a significant problem, with many physicians finding it difficult to differentiate between the various pain types; and, many underestimating its severity. Poor diagnosis, poor assessment, the choice of less appropriate treatments, plus patients and physicians fears about controlled drugs such as morphine all contribute to under treatment of cancer pain. cache = ./cache/cord-009891-gqrhbhbn.txt txt = ./txt/cord-009891-gqrhbhbn.txt === reduce.pl bib === id = cord-009512-o4y9s8zf author = Huang, Jiajia title = Primary pulmonary non‐Hodgkin's lymphoma: A retrospective analysis of 29 cases in a Chinese population date = 2010-03-24 pages = extension = .txt mime = text/plain words = 21926 sentences = 1115 flesch = 51 summary = The authors in this study report the incidence and risk factors associated with the development of solid tumors in 4349 pediatric and adult patients who underwent allogeneic stem cell transplant (SCT) for acute myelogenous leukemia (AML) in CR1 or chronic myelogenous leukemia (CML) in first chronic phase. The lower hOCT1 mRNA expression level in LEU from IMA naïve de novo CML patients compared to healthy volunteers as well as its progressive increase after the start of IMA therapy could be explained by the initial presence and subsequent gradual disappearance of tumor cells from the measured cell population. To confirm this hypothesis, we performed an analysis on the relationship of hOCT1 expression with the percentage of immature myeloid cells in the LEU samples (as a marker of disease burden) obtained from IMA naïve de novo CML patients. cache = ./cache/cord-009512-o4y9s8zf.txt txt = ./txt/cord-009512-o4y9s8zf.txt === reduce.pl bib === id = cord-010116-hfzs16jh author = Díaz‐Ravetllat, V. title = Significance of new lung infiltrates in outpatients after lung and heart–lung transplantation date = 2014-04-12 pages = extension = .txt mime = text/plain words = 4254 sentences = 256 flesch = 40 summary = Other causes of pulmonary infiltrates include acute cellular rejection, chronic lung allograft dysfunction Abbreviations: AR, acute rejection; BAL, bronchoalveolar lavage; BOS, bronchiolitis obliterans syndrome; CFU, colony-forming units; CLAD, chronic lung allograft dysfunction; CMV, cytomegalovirus; CRP, C-reactive protein; FEV1, forced expiratory volume in the first second; IQR, interquartile range; ISHLT, International Society of Heart and Lung Transplantation; LTR, lung transplant recipients; LTx, lung transplantation; SOT, solid organ transplant; TBB, transbronchial biopsy (CLAD), and drug toxicity. Patients A retrospective analysis was performed of all LTR and heart-lung transplant recipients attending the outpatient clinic at our institution between September 1, 2006 and October 14, 2011. Pulmonary infiltrates on postoperative chest x-rays are common in lung vascular injury of the donor, re-implantation disease (24) , reperfusion edema (25), or primary graft dysfunction (26) , vascular obstruction, adult respiratory distress syndrome (27) , infection, atelectasis (26) , rejection, pharmacological toxicity, and post-transplantation lymphoproliferative disorders (28) . cache = ./cache/cord-010116-hfzs16jh.txt txt = ./txt/cord-010116-hfzs16jh.txt === reduce.pl bib === id = cord-006860-a3b8hyyr author = nan title = 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date = 1996 pages = extension = .txt mime = text/plain words = 90660 sentences = 5152 flesch = 50 summary = Dept of Pediatrics, University Hospitals Kiel and Mtinster, Germany Resistance to activated protein C (APCR), in the majority of cases associated with the Arg 506 Gin point mutation in the factor V gene is present in more than 50 % of patients < 60 years of age with unexplained thrombophilia. The regular APC resistance test is not applicable to plasma from Orally anticoagulated (OAC) or heparinized patients due to decreased levels of vitamin K-dependent clotting factors and to thrombin inhibition by antithrombin, respectively. On admission an extensive coagulation screen yielded the following results (n/normal, t/elevated, I/reduced, +/positive, -/negative): PT t, aPTT t, Tr n, factor II, V, VIII n, factor VII, IX, XI, XII /,, fibrinogan t, ATIII n, protein C, S *, activated protein C sensitivity ratio 1.92 ($), FV-Leidenmutation PCR -, fibrinolytic system n, TAT t, Ft÷2 t, lupus anticoagulant +, heparin induced platelet antibodies +; no diagnosis of a specific autoimmuna disorder could be made. cache = ./cache/cord-006860-a3b8hyyr.txt txt = ./txt/cord-006860-a3b8hyyr.txt === reduce.pl bib === id = cord-007577-f1jzbtjj author = Raphael Shulman, N. title = Hepatitis-associated antigen date = 2006-09-18 pages = extension = .txt mime = text/plain words = 13821 sentences = 577 flesch = 39 summary = Frequency of HAA in acute hepatitis: After the initial suggestion in 1967 by Blumberg and co-workers [4] that Australia antigen might be related to the infectious agent of viral hepatitis, and the demonstration in 1968 by Okochi and Murakami [5] and Prince [6] that the antigen appeared in blood of patients during the incubation period of serum hepatitis, a number of investigators reported further evidence for existence of a hepatitis-associated antigen (Table II) . The antibodies used diagnostically to measure HAA by precipitin and complement fixation technics all come from patients who have received multiple transfusions and in whom high titer "hyperimmune" anti-HAA developed apparently as a result of repeated exposure to antigen in transfused blood. [29] tested serum obtained at weekly intervals from twenty-two patients with HAA-positive hepatitis during a one to two month period after onset of disease and found only one antibody detectable by agar gel precipitin technics and two antibodies of low titer detectable only by complement fixation. cache = ./cache/cord-007577-f1jzbtjj.txt txt = ./txt/cord-007577-f1jzbtjj.txt === reduce.pl bib === id = cord-009575-bd67ph64 author = Berr, C. title = Risk factors in multiple sclerosis: a population‐based case‐control study in Hautes‐Pyrénées, France date = 2009-01-29 pages = extension = .txt mime = text/plain words = 1965 sentences = 118 flesch = 57 summary = ABSTRACT‐ A population‐based study of the prevalence and risk factors of multiple sclerosis (MS) was conducted in the Hautes‐Pyrénées, the southwestern region of France. The mumps antibody titer was significantly higher in the MS patients than in the controls. Patients and controls were asked whether they had ever contracted the following infectious diseases: rubella, measles, varicella, mumps, viral hepatitis, herpes simplex, zoster, pertussis, chronic sinusitis, and upper airways infections ( Table 2) . Age at the time of immunization was significantly higher for patients than controls (15.8 years versus 8.9 years, A history of familial MS was reported by 4 There was no association between antibody levels and clinical features, including sex, age at onset of MS, and the course of the disease. Nevertheless, MS patients tended to have higher measles antibody titers than controls. Risk factors in multiple sclerosis: tuberculin reactivity, age at measles infection, tonsillectomy and appendicectomy Viral infection in patients with multiple sclerosis and HLA-DR matched controls cache = ./cache/cord-009575-bd67ph64.txt txt = ./txt/cord-009575-bd67ph64.txt === reduce.pl bib === id = cord-009322-7l7slziv author = Kraetsch, Hans-Georg title = Verlauf und prognostische Parameter bei Still-Syndrom des Erwachsenen: Eigene Erfahrungen und Literaturübersicht date = 1997 pages = extension = .txt mime = text/plain words = 2073 sentences = 269 flesch = 57 summary = □ PATIENTS AND METHODS: Ten patients with adult onset of Still's disease (AOSD) were examined one to nine years after the established diagnosis. 1 971 beschfieb Bywaters 14 erwachsene Patienten mit Symptomen ~ihnlich denen einer juvenilen chronischen Polyarthritis, die frª als ,,Still's disease" bezeichnet wurde [3] . Rey Words: AOSD 9 Adult onset of Still's disease 9 Prognostic critefia 9 Course of disease 9 Outcome 9 Review of the literature 9 Case reports Med. Klin Betroffen sind vor allem der Stamm und die proximalen Extremiditen (Abbildung 2, Patient Nr. 8), gelegentlich aber auch das Gesicht [18] . Eine schwere hepatische Beteili~mg trat bei unserem sp~iter verstorbenen Patienten ira P,.ahmen eines hffmophagozytischen Syndroms auf[28], auch dies schon als seltene und lebensbedrohliche Komplikation des AOSD bekannt. Eine Verschmfflerung des Gelenkspaltes in Karpometakarpaloder Interkarpalgelenken mit sp~iterer kn6cherner Ankylosierung gilt als eine ftir das AOSD charakteristische radiologische Verffnderung [1] , die in dieser Forro bei unseren Patienten nicht zu beobachten war. cache = ./cache/cord-009322-7l7slziv.txt txt = ./txt/cord-009322-7l7slziv.txt === reduce.pl bib === id = cord-009507-l74c9x0n author = Singh, Amandeep title = Clinicopathological Conference: Fever, Productive Cough, and Tachycardia in a 22‐year‐old Asian Male date = 2008-01-08 pages = extension = .txt mime = text/plain words = 4395 sentences = 291 flesch = 42 summary = To generate the appropriate differential diagnosis in this case, there are several key features of the patient's history and physical examination that aid in the understanding of his pathologic process: 1) symptom development occurred soon after emigration from Indonesia, 2) the patient's primary symptoms were pulmonary in origin, and 3) secondary cardiac involvement resulted in a large, initially asymptomatic pericardial effusion. 10 Acute infection begins with sudden onset of one or more of the following: high fevers (up to 104-1058F), severe headache, general malaise, myalgia, confusion, sore throat, chills, sweats, nonproductive cough, nausea, vomiting, diarrhea, abdominal pain, and chest pain. In our patient, the most likely cause of the pericardial effusion was infection with tuberculosis. To summarize, this patient's recent immigration, symptoms of intermittent fever and of chronic cough that failed to respond to outpatient antibiotics, and development of large pericardial effusion all are consistent with a diagnosis of tuberculosis. cache = ./cache/cord-009507-l74c9x0n.txt txt = ./txt/cord-009507-l74c9x0n.txt === reduce.pl bib === id = cord-010078-8lkkez3n author = nan title = Invited Speakers date = 2010-11-24 pages = extension = .txt mime = text/plain words = 21351 sentences = 1012 flesch = 43 summary = Both modes of imaging discriminate early malignant lesions from non-specifi c infl ammation, aid in selecting appropriate sites for biopsy and better delineate tumor margins for more precise staging, but are of little value at present in clinical practice since most patients with malignant pleural effusions have extensive pleural involvement that is easy to diagnose with white light pleuroscopy For pleuroscopic guided pleural biopsies, specimens obtained with the rigid forceps are larger than those with the fl ex-rigid pleuroscope since they are limited by size of the fl exible forceps, which in turn depends on the diameter of the working channel. In the United Kingdom, a thrombosis group has been formed to promote awareness among parliamentarians about the risk and management of VTE; to increase knowledge of its causes, effects, and treatments; and to monitor the implementation of government initiatives and other researches being and this program has corrected the wrong perception that PTE is a rare disease in China Pulmonary hypertension (PH) is a common complication of chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) or interstitial lung diseases (ILD). cache = ./cache/cord-010078-8lkkez3n.txt txt = ./txt/cord-010078-8lkkez3n.txt === reduce.pl bib === id = cord-010487-wncgecld author = Rinella, Mary E. title = STELLAR 3 and STELLAR 4: Lessons From the Fall of Icarus date = 2020-04-30 pages = extension = .txt mime = text/plain words = 1408 sentences = 72 flesch = 51 summary = Here, the ASK-1 inhibitor, selonsertib, was compared to placebo in ~1700 patients with NASH and bridging fibrosis (F3, STELLAR-3) or compensated cirrhosis (F4, STELLAR-4). In the absence of a placebo controlled phase 2b study, STELLAR 3 and 4 were substantially informed by a phase 2 study, [5] in which NASH patients with F2/F3 were recruited in a multicenter trial and randomized in a 2:2:1:1:1 ratio to receive 24 weeks of treatment with 6 mg or 18 mg of selonsertib alone; 6 mg or 18 mg of selonsertib with 125 mg of simtuzumab; or 125 mg of simtuzumab alone. The STELLAR studies did not meet their primary outcomes, and selonsertib was ineffective in reversing fibrosis in NASH patients with stage F3 and F4 fibrosis -those most in need of treatment. A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials cache = ./cache/cord-010487-wncgecld.txt txt = ./txt/cord-010487-wncgecld.txt === reduce.pl bib === id = cord-009571-mygj2nd4 author = nan title = Proceedings of the 42nd annual meeting of the american rheumatism association a section of the arthritis foundation june 1 & 2, 1978 new york city abstracts of papers presented date = 2005-11-23 pages = extension = .txt mime = text/plain words = 46150 sentences = 2284 flesch = 49 summary = Levels of Ty cells as well as total T lymphocytes were measured in 19 patients with systemic lupus erythematosus (SLE), 11 with active and 8 with inactive disease, and in 47 normal subjects. The diagnosis of GC arthritis were studied for the presence of GC antigen (AG) and anti-in all seven patients was made by typical clinical presentation, body (AB) in serum and synovial fluid by counter-positive local culture for Ngonorrhoeae (NG) , and response to treatment. A retrospective study was instituted on 10 patients in the UCLA lupus nephritis clinic in an attempt to determine the ability of three serologic indicators-specifically immune complexes (IC), anti-DNA antibodies (DNA-ab), and C3-to predict the activity of SLE renal disease as indicated by changes in 24 hour proteinuria, serum creatinine, and creatinine clearance. cache = ./cache/cord-009571-mygj2nd4.txt txt = ./txt/cord-009571-mygj2nd4.txt === reduce.pl bib === id = cord-006854-o2e5na78 author = nan title = Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date = 2018-04-20 pages = extension = .txt mime = text/plain words = 166047 sentences = 10353 flesch = 47 summary = Totally Laparoscopic ALPPS Combined with the Microwave Ablation for a Patient with a Huge HCC Hua Zhang; Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University Introduction: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel technique for resecting hepatic tumors that were previously considered unresectable due to the insufficient future liver remnant (FLR) which may result in postoperative liver failure (PLF). Not only does this case show that a large epiphrenic diverticulm can be successfully resected via the trans-abdominal laparoscopic approach, this case makes the argument that patients undergoing any minimally-invasive epiphrenic diverticulectomy and myotomy, with or without fundoplication, may be successfully managed with early post-operative contrast studies and dietary advancement, thus decreasing their length of hospitalization and overall cost of treatment. Introduction: There are reports of increased operative duration, blood loss and postoperative morbidity, caused by difficulties in obtaining good visualization and in controlling bleeding when laparoscopic resection is performed in obese patients with colon cancer. cache = ./cache/cord-006854-o2e5na78.txt txt = ./txt/cord-006854-o2e5na78.txt === reduce.pl bib === === reduce.pl bib === id = cord-009982-zgbu46fo author = Cies, Jeffrey J. title = Peramivir for Influenza A and B Viral Infections: A Pharmacokinetic Case Series date = 2019-10-04 pages = extension = .txt mime = text/plain words = 2899 sentences = 167 flesch = 40 summary = DESIGN: Retrospective electronic medical record review of prospectively collected data from critically ill children receiving peramivir for influenza A or B viral infections in the pediatric intensive care unit (PICU). CONCLUSION: The pharmacokinetics of PRV demonstrated in this PICU cohort differs in comparison to healthy pediatric and adult patients, and alterations to dosing regimens may be needed in PICU patients to achieve pharmacodynamic exposures. 20 The current FDA-approved pediatric dosing regimen is recommended based on pharmacokinetic data to approximate a total drug exposure or AUC similar to that achieved in adults that was associated with safety and efficacy. 3 The pharmacokinetic data from these 11 PICU patients suggest that dosing modifications would be needed for PRV to better achieve drug exposures similar to those described earlier 3 and in the PI. cache = ./cache/cord-009982-zgbu46fo.txt txt = ./txt/cord-009982-zgbu46fo.txt === reduce.pl bib === id = cord-010856-3g0123lk author = Araghi, Ariyan S. title = An audit to analyse the two-week wait pathway at an oral cancer specialist district general hospital date = 2020-05-08 pages = extension = .txt mime = text/plain words = 5099 sentences = 278 flesch = 60 summary = Cross-pathway referral for these cancers allows both general medical practitioners (GMPs) and general dental practitioners (GDPs) to refer patients to be seen within two weeks by a specialist secondary care consultant in an oral maxillofacial cancer unit. To analyse whether the positively diagnosed cancer patients were being given their initial diagnosis within 28 days, in preparation for the new guidelines to be implemented in the NHS Long Term Plan (2020) 5. One hundred percent of the patients positively diagnosed with cancer would receive diagnosis within 28 days and subsequent treatment within 62 days in line with the current guidelines for the 2ww referral system for HNCs. The standard for diagnostic cancer yield/positive oncological transformation would be set at 3%, as appropriate for a screening test as set out by NHS England. cache = ./cache/cord-010856-3g0123lk.txt txt = ./txt/cord-010856-3g0123lk.txt === reduce.pl bib === id = cord-010658-67k8pthy author = Bernard, Andie title = PC-FACS May 2020 for July 2020 Issue date = 2020-05-07 pages = extension = .txt mime = text/plain words = 1923 sentences = 123 flesch = 45 summary = To expertly guide patients through this often devastating illness, palliative care professionals will need to keep abreast of the COVID-19 literature as the pandemic evolves and the longer-term outcomes come into sharper focus. Bottom Line: Early reports of COVID-19-associated pneumonia and ARDS provide insights into risk factors, short-term prognosis, and mortality that are important for palliative care professionals to be aware of when counselling patients and families. This article discussed a component of an appropriate response to the COVID-19 pandemic: ensuring that clinicians have discussions about advance care planning (especially with older patients with chronic illness) and goals of care with patients/families. This pandemic heightens the importance of implementing do-not-resuscitate (DNR) orders for appropriate patients: although unwanted/nonbeneficial CPR always risks increasing psychological distress for patients' families, inappropriate CPR now is especially stressful and potentially dangerous for healthcare workers. cache = ./cache/cord-010658-67k8pthy.txt txt = ./txt/cord-010658-67k8pthy.txt === reduce.pl bib === id = cord-009667-8r8j0h08 author = Cao, Bin title = Diagnosis and treatment of community‐acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association date = 2017-09-26 pages = extension = .txt mime = text/plain words = 11049 sentences = 657 flesch = 33 summary = 13, 17 Recently, the results of 2 multicenter Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CAR-TIPS) studies in adults conducted in urban tertiary hospitals in China showed that 88.1%-91.3% of S. Step 3: Predict the potential pathogens of CAP and risks of antibiotic resistance ( Table 2) : considering patient age, season of onset, underlying diseases and risk factors, symptoms or signs, characteristics of chest imaging (X-ray film or CT), laboratory tests, severity of CAP, prior antibacterial therapies and so on. After clinical diagnosis of CAP is established, and etiological test and sampling arranged appropriately, the most potential pathogens should be assessed in terms of patient age, underlying disease, clinical characteristics, results of laboratory and radiography tests, severity of disease, hepatic and renal functions, and history of medication and antimicrobial susceptibility profile, then evaluate the risk for antibiotic resistance, select the appropriate anti-infective agent (s) and dosing regimen ( Table 6 ). cache = ./cache/cord-009667-8r8j0h08.txt txt = ./txt/cord-009667-8r8j0h08.txt === reduce.pl bib === id = cord-010261-sy7esszi author = Tenenbein, Milton title = Early coagulopathy in severe iron poisoning date = 2006-08-17 pages = extension = .txt mime = text/plain words = 1333 sentences = 92 flesch = 49 summary = Our observations suppol:t the presence of an early, reversible coagulopathy dependent on the serum iron concentration in poisoned patients. Its onset is usually delayed for at least 24 hours after iron ingestion, making the early coagulation abnormalities in patients 1 and 2 noteworthy. The coagulation measurements in patient 1 also improved coincident with a precipitous fall in serum iron concentration and prior to the onset of the hepatic coagulopathy. The initial ~hase, occurring within hours of overdose, appears to be a functional, reversible, and serum iron concentration-dependent impairment of coagulation. 6 If additional experience confirms the presence of an early coagulopathy in severe iron poisoning, the presence of early coagulation abnormalities could also suggest the need for deferoxamine therapy. Identification of respiratory virus antigens in middle ear fluids of children with acute otitis media cache = ./cache/cord-010261-sy7esszi.txt txt = ./txt/cord-010261-sy7esszi.txt === reduce.pl bib === id = cord-010999-u2guhh3h author = Blackstone, Eric title = Making Medical Decisions for Incapacitated Patients Without Proxies: Part II date = 2019-11-06 pages = extension = .txt mime = text/plain words = 6590 sentences = 343 flesch = 52 summary = 2019 ) by providing a qualitative, retrospective look at the process of decision-making for PWPs. Using case examples and excerpts from semi-structured interviews with 12 committee members, we will discuss how the protocol has translated into practice. If no legally acceptable surrogate can be located, the ethics consultant contacts the PWP committee members to recruit 2-3 individuals who can meet with representatives from the medical team within 24-48 h. • Demographic questions (age, sex, religion, education, occupation) • Personal experience in healthcare decision-making (for self or family members) • Member's assessment of personal qualifications required for committee membership and preparation for role • Member's experience with PWP cases (mechanics, medical and social information provided, quality of discussion, meeting the patient) • Member's views on how personal values and religious beliefs affect their decision-making • Member's experience and views on the post-decision period (second-guessing, need for feedback, debriefing) cache = ./cache/cord-010999-u2guhh3h.txt txt = ./txt/cord-010999-u2guhh3h.txt === reduce.pl bib === id = cord-009697-dq4y89ab author = Yuen, Eddie title = Role of absolute lymphocyte count in the screening of patients with suspected SARS date = 2003-07-25 pages = extension = .txt mime = text/plain words = 1510 sentences = 92 flesch = 59 summary = 3 This multicentre, placebo-controlled, randomized, double-blind trial in 6213 patients with acute ST-elevation myocardial infarct (STEMI) found that magnesium sulphate, (2 g intravenous bolus over 15 min followed by a 17 g infusion over 24 h), administered within 6 hours of onset of symptoms did not have any effect on the primary end-point of 30 day all-cause mortality when compared with placebo (15.3% 30 day mortality in the magnesium group vs 15.2% in the placebo group; odds ratio 1.0; 95% CI 0.9-1.2; P = 0.96). As the investigators point out in the discussion of their paper, this means that 68 684 patients have been studied over the past 22 years in 14 randomized trials of magnesium in myocardial infarction. Second, a multicentre, placebo-controlled, randomized, double-blind trial of intravenous magnesium sulphate in 248 patients with acute severe asthma was recently reported. cache = ./cache/cord-009697-dq4y89ab.txt txt = ./txt/cord-009697-dq4y89ab.txt === reduce.pl bib === id = cord-011138-y9v5ivzg author = Hatchimonji, Justin S. title = Questioning dogma: does a GCS of 8 require intubation? date = 2020-05-07 pages = extension = .txt mime = text/plain words = 3232 sentences = 179 flesch = 52 summary = We investigated the effect of intubation in trauma patients with a GCS 6–8, with the hypothesis that intubation would increase mortality and length of stay. CONCLUSION: Among patients with GCS of 6 to 8, intubation on arrival was associated with an increase in mortality and with longer ICU and overall length of stay. Likewise, the Eastern Association for the Surgery of Trauma (EAST) practice management guidelines (PMGs) give a level 1 recommendation for intubation for patients with a GCS of 8 [2, 3] . Using IPWRA analysis adjusted for GCS, age, sex, hypotension, maximum head, chest, and abdomen/pelvis abbreviated injury scale (AIS) scores, we determined that the average treatment effect (ATE) of intubation was associated with increased odds of mortality (OR 1.05, 95% CI 1.03-1.06). Among patients with GCS of 6-8, intubation on arrival was associated with increased mortality, ICU days, and overall length of stay. cache = ./cache/cord-011138-y9v5ivzg.txt txt = ./txt/cord-011138-y9v5ivzg.txt === reduce.pl bib === id = cord-010844-y26y5myb author = Lessing, Noah L. title = Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why? date = 2020-04-29 pages = extension = .txt mime = text/plain words = 4431 sentences = 243 flesch = 46 summary = OBJECTIVES: In a cohort of patients with traumatic spine injury (TSI) in Tanzania who did not undergo surgery, we sought to: (1) describe this nonoperative population, (2) compare outcomes to operative patients, and (3) determine predictors of nonoperative treatment. Patients with AO type A0/1/2/3 fractures (p < 0.001), ASIA E exams (p = 0.016), cervical spine injuries (p = 0.005), and central cord syndrome (p = 0.016) were more commonly managed nonoperatively. Surgery for TSI is offered in a small number of tertiary centers throughout Sub-Saharan Africa and other LMICs. Despite studies showing that nonoperative treatment is associated with worse outcomes [3] , operative rates remain low in resource-constrained settings [4, 5] . After multivariate analysis controlling for age, gender, insurance status, mechanism of injury, fracture stability, injury level, and exam on admission (ASIA grade), patients managed nonoperatively were 7.39 times more likely to die compared with patients undergoing surgery (95% CI: 2.18, 30.5 | p = 0.003) ( Table 3 ). cache = ./cache/cord-010844-y26y5myb.txt txt = ./txt/cord-010844-y26y5myb.txt === reduce.pl bib === id = cord-010477-g754gjvh author = Carney, Kevin P. title = A Front-end Redesign With Implementation of a Novel “Intake” System to Improve Patient Flow in a Pediatric Emergency Department date = 2020-02-27 pages = extension = .txt mime = text/plain words = 3735 sentences = 210 flesch = 52 summary = Key process elements included (1) new Flow Nurse/EMT roles, (2) elimination of traditional registration and triage processes, (3) immediate "quick registration" and nurse assessment upon walk-in, (4) direct-bedding of patients, and (5) a novel "Intake" system staffed by a pediatric emergency medicine physician. CONCLUSIONS: Using quality improvement and Lean methodology, an inter-professional team decreased door-to-provider times and LWBS rates in a large pediatric ED by redesigning its front-end processes and implementing a novel pediatric emergency medicine-led Intake system. Strategies employed to improve the front-end processes include the abolishment of traditional nurse-led triage, "split-flow" models that create separate patient streams depending on each individual's particular care needs, direct-bedding of patients, and placing providers in triage. Using QI and Lean methodology, an inter-professional team in a large, tertiary-care pediatric ED designed and implemented a novel front-end system and significantly improved patient flow by decreasing door-to-provider times 49% and LWBS rates by over 50%. cache = ./cache/cord-010477-g754gjvh.txt txt = ./txt/cord-010477-g754gjvh.txt === reduce.pl bib === id = cord-009713-sxd4t2tz author = nan title = Poster Presentations date = 2020-01-10 pages = extension = .txt mime = text/plain words = 43950 sentences = 2945 flesch = 52 summary = Poster No. 010 Seizure, developmental and cognitive outcomes in children post hemispherotomy TT TAY 1 , DR REED 2 , VJ JOSAN 3 , SR RUST 4 , JT TAN 5 1 University of Manchester, Manchester, UK; 2 Neuropsychology Team, Paediatric Psychosocial Service, Royal Manchester Children's Hospital, Manchester, UK; 3 Neurosurgery, Salford Royal NHS Foundation, Manchester, UK; 4 Paediatric Neuropsychology, Royal Manchester Children's Hospital, Manchester, UK; 5 Paediatric Neurology, Royal Manchester Children's Hospital, Manchester, UK Introduction: Patients with focal refractory epilepsy secondary to structural hemispheric changes have been shown in retrospective studies to have significantly improved seizure outcomes following hemispheric disconnection. In a univariate analysis of 682 cases with ≥12 months follow-up data, poor final outcome (defined as modified Rankin Scale [mRS] score 3-6) occurred in 30% and was associated with very young or elderly age at onset, movement disorder, decreased consciousness, autonomic dysfunction, mechanical ventilation, higher mRS score in the acute phase, longer hospital stay, extreme delta brush on EEG, abnormal MRI, CSF pleocytosis and elevated CSF protein (all p<0.05). cache = ./cache/cord-009713-sxd4t2tz.txt txt = ./txt/cord-009713-sxd4t2tz.txt === reduce.pl bib === id = cord-011159-k2kca8zl author = Kamel, Toufik title = Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study date = 2020-01-07 pages = extension = .txt mime = text/plain words = 5114 sentences = 230 flesch = 46 summary = b Patient recruitment exceeded the 500 expected, because we anticipated a number of non-workable case report forms h More than one indication could be present for each BAL i Significantly higher than in the nasal high-flow oxygen therapy or non-invasive ventilation group (p < 0.001), and then in the invasive mechanical ventilation group (p = 0.001) j H0 indicates the time at which BAL has began k Experience in years in the specialty and in terms of number of BAL performed are detailed in Table S1 of the Online resource 1 l We defined the physician performing the BAL as an "experienced physician" when he/she was a pulmonologist or when he/she was an intensivist with the greatest experience (i.e., > 10 years in the specialty or > 50 BAL performed) 35-3.50 ]; p = 0.002) and the amount of BAL fluid (in ml) recovered handled as a linear predictor (OR 1.02 [1.01-1.03] per 1 ml increase; p < 0.01), were statistically significant predictors of a BAL fluid of good quality (Table S6 ). cache = ./cache/cord-011159-k2kca8zl.txt txt = ./txt/cord-011159-k2kca8zl.txt === reduce.pl bib === === reduce.pl bib === id = cord-009788-bc6sc2rc author = Ferguson, J. K. title = Preventing healthcare‐associated infection: risks, healthcare systems and behaviour date = 2009-09-17 pages = extension = .txt mime = text/plain words = 3554 sentences = 200 flesch = 41 summary = The Quality in Australian Health Care Study (QAHCS) 1 estimated that 5.5% of hospital admissions were affected by healthcare-associated infection (HAI), with an estimate at that time of 155 000 infections per annum across Australia. 11 MRSA infected or colonized patients admitted to hospital increase the risk of MRSA spread to healthcare staff and their families. 16 Healthcare staff and other patients must be protected from infectious fine particle (<5 mM) aerosols that are capable of transmitting infection at low doses †Active screening and isolation for methicillin-resistant Staphylococcus aureus-colonized patients/staff is not performed at some Australian sites as it is considered to be an ineffective measure. [22] [23] [24] A national initiative commenced in 2008 to improve hand hygiene, focusing on education, provision of alcohol-based hand rub at every bedside, reliable, regular audits of compliance with effective feedback to staff and management, and measurement of patient infection outcomes (healthcare-associated S. cache = ./cache/cord-009788-bc6sc2rc.txt txt = ./txt/cord-009788-bc6sc2rc.txt === reduce.pl bib === id = cord-010036-6czkzek0 author = Lorentz, I T title = Treatment of idiopathic spasmodic torticollis with botulinum‐A toxin: a pilot study of 19 patients date = 1990-05-01 pages = extension = .txt mime = text/plain words = 3198 sentences = 200 flesch = 52 summary = title: Treatment of idiopathic spasmodic torticollis with botulinum‐A toxin: a pilot study of 19 patients Nineteen patients with spasmodic torticollis, unresponsive to standard therapy, were administered local injections of botulinum‐A toxin into the affected muscles. Botulinum toxin is a very effective and safe method of treatment for spasmodic torticollis, (Med J Aust 1990; 152: 528-530) T he term "dystonia" was coined by Oppenheim in 1911 1 in describing six patients with alterations in muscle tone, sustained posturing and involuntary movements. A 48-year-old male mechanic suffering from haemochromatosis, which was treated with weekly venesections, developed spasmodic torticollis 18 months before he was referred for botulinum toxin treatment. In up to 15% of patients with ST the symptoms may remit in the first five years of the illness, so some cases of improvement may be examples of a natural remission hastened by botulinum toxin injections. Controlled trial of botulinum toxin injections in the treatment of spasmodic torticollis cache = ./cache/cord-010036-6czkzek0.txt txt = ./txt/cord-010036-6czkzek0.txt === reduce.pl bib === id = cord-010929-d598h08w author = Kashiwagi, Hirokazu title = Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision date = 2020-01-02 pages = extension = .txt mime = text/plain words = 11814 sentences = 563 flesch = 42 summary = Patients who do not achieve the therapeutic target with corticosteroids or require long-term administration of high-dose corticosteroids, or patients unable to tolerate corticosteroids due to complications or adverse drug reactions, are transitioned to second-line treatment. High-dose intravenous immunoglobulin, methylprednisolone pulse therapy, or platelet transfusion should be considered for patients with severe bleeding symptoms, marked thrombocytopenia or who urgently require an increase in their platelet count because of surgery or for some other reason. In patients with underlying diseases (hypertension,diabetes,active infections, chronic infections,impaired immune status,osteoporosis,dys lipidemia,peptic ulcer, etc.) with a high probability of problematic adverse drug reactions associated with corticosteroid treatment, it is recommended that corticosteroids be started while controlling complications. However, the percentage of patients who had a partial response with a platelet count of 30,000-50,000/μL was 57.6% in the rituximab group and 46.7% in the standard treatment group, with a relative risk of 1.26 (95% CI: 0.95-1.67, p = 0.11), indicating that there was no significant difference in the bleeding inhibition effect between the two groups. cache = ./cache/cord-010929-d598h08w.txt txt = ./txt/cord-010929-d598h08w.txt === reduce.pl bib === id = cord-006849-vgjz74ts author = nan title = 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date = 2019-09-13 pages = extension = .txt mime = text/plain words = 222162 sentences = 14023 flesch = 48 summary = Methods: We are performing this procedures within a prospective randomized trial that is design to compare the long term results of LRYGB-B versus the standard laparoscopic Roux-en-Y gastric bypass.The video shows our technique in a case of a 46 years old female with a BMI of 46 Kg/m2. Material and methods: We present a video of the surgical intervention of a 32-year-old patient, with functional dyspepsia, with a casual diagnosis of a pseudocystic mass of the right colon after performing a CT scan: giant diverticulum of the hepatic colon angle with fecaloid content inside it under tension The patient goes to the emergency room for acute abdominal pain, pending colonoscopy, antibiotic treatment is established, and a laparoscopic approach is decided upon after the patient's evolution. Method: We present the case of a 65-year-old patient with surgical antecedent of laparoscopic low anterior resection due to rectal cancer, presenting in postoperative period an anastomosis leakage with severe peritonitis was identified and a laparotomy with end colostomy was performed. cache = ./cache/cord-006849-vgjz74ts.txt txt = ./txt/cord-006849-vgjz74ts.txt === reduce.pl bib === id = cord-010141-955r29sd author = Sibila, Oriol title = Nonantibiotic Adjunctive Therapies for Community-Acquired Pneumonia (Corticosteroids and Beyond): Where Are We with Them? date = 2016-12-17 pages = extension = .txt mime = text/plain words = 4019 sentences = 213 flesch = 37 summary = The purpose of this review is to assess the evidence related to corticosteroids and other nonantibiotic adjunctive therapies use and clinical outcomes in patients with CAP, with special interest in studies published in the last 10 years. These authors demonstrated a mortality reduction in the group treated with corticosteroids, a better modulation of systemic inflammatory response, and significant improvement in clinical endpoints, such as chest X-ray, multiple organ dysfunction syndrome severity scale, PaO 2 :FiO 2 ratio, and ICU and hospital stay. Our group demonstrated that acute administration of methylprednisolone (0.5 mg/kg/12 hours during 5 days) decrease treatment failure in a population of 120 patients with severe CAP who had high inflammatory response (defined as CRP greater than 150 mg/L on admission). Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial cache = ./cache/cord-010141-955r29sd.txt txt = ./txt/cord-010141-955r29sd.txt === reduce.pl bib === id = cord-010416-u0yo0lk6 author = Tejada, Sofia title = Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials date = 2020-04-28 pages = extension = .txt mime = text/plain words = 4008 sentences = 207 flesch = 38 summary = A systematic review of randomized controlled trials (RCTs) was conducted to evaluate the efficacy and safety of alternative neuraminidase inhibitor (NAI) regimens compared to standard of care in patients hospitalized for H1N1, H3N2, or B influenza. Thus, the study's aim was to perform a systematic review (SR) of randomized controlled trials (RCT) to evaluate the efficacy and safety of alternative NAI regimens compared with 75 mg orally administered oseltamivir twice/daily or 600 mg intravenously administered peramivir once/daily in patients hospitalized for H1N1, H3N2, or B influenza. The evidence evaluated in this SR indicates that the alternative NAI regimens to orally administered oseltamivir 75 mg twice/daily or intravenously administered peramivir 600 mg once/daily to treat hospitalized patients with influenza infection are equally safe but do not modify meaningful clinical outcomes when compared with the standard dose. cache = ./cache/cord-010416-u0yo0lk6.txt txt = ./txt/cord-010416-u0yo0lk6.txt === reduce.pl bib === id = cord-010461-un9pls28 author = Manohar, Sujal title = A Three-part Quality Improvement Initiative to Increase Patient Satisfaction and Reduce Appointment Time date = 2020-03-09 pages = extension = .txt mime = text/plain words = 3192 sentences = 207 flesch = 53 summary = METHODS: PediPlace introduced 3 interventions: improved patient tracking to measure timing on the electronic health record interface, elimination of script repetition between medical assistants and providers, and patient art kits. PediPlace implemented 3 interventions and measured the impact by tracking survey responses and total appointment length. PediPlace compared appointment lengths between July-December 2018 and January-June 2019, dividing the year into 2 parts before and after 2 of the QI interventions (revising MA and provider scripts and improving tracking). The clinic studied how different factors, such as patient age, patient ethnicity, provider, and time of year, impacted the total appointment length. PediPlace did not examine time spent during each part of the visit, such as "time with provider" or "time waiting for immunizations." This analysis is a potential area for future data collection because even a 5-minute difference in appointment length can alter patient perceptions of the healthcare experience. cache = ./cache/cord-010461-un9pls28.txt txt = ./txt/cord-010461-un9pls28.txt === reduce.pl bib === id = cord-009967-fyqc5bat author = Gleckman, Richard title = Cost‐Effective Antibiotic Prescribing date = 2012-01-24 pages = extension = .txt mime = text/plain words = 5938 sentences = 307 flesch = 30 summary = Recent studies have confirmed the efficacy and reduced expense of oral antibiotics prescribed for selected children with osteomyelitis and septic arthritis.1"22 In 1973, it was reported that favorable results ensued when oral antibiotic therapy was prescribed for hospitalized patients with serious infectionsz3 Fourteen patients with osteomyelitis were treated successfully with oral cephalexin after they had received a short course of parenteral cephaloridine. Adults with disseminated gonococcal infection can be effectively treated with a one week program consisting initially of 2 million units of penicillin G administered every 4 hours followed by oral ampicillin or amoxicillin prescribed as 500 mg four times daily.34,35 Hospitalization is usually recommended to establish the diagnosis of disseminated gonococcal disease since misdiagnosis occurs not infrequently with this disorder.33 Selected patients can complete the oral regimens in an outpatient setting or, alternatively, they can be treated entirely without ho~pitalization.~~ Acceptable oral regimens consist of giving amoxicillin (500 mg four times daily), tetracycline (500 mg four times daily), or erythromycin (500 mg four times daily) for at least 7 days. cache = ./cache/cord-009967-fyqc5bat.txt txt = ./txt/cord-009967-fyqc5bat.txt === reduce.pl bib === id = cord-010564-7c9h16bi author = Unolt, Marta title = Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition date = 2019-09-02 pages = extension = .txt mime = text/plain words = 4682 sentences = 274 flesch = 44 summary = Based on the clinical presentation of these patients and on the recurrent phenotype of the patients with pathogenic variants in the CDC45 gene (Table 1) , reported by Fenwick et al., 5 we further expanded the atypical findings spectrum, to include rare gastrointestinal anomalies, such as intestinal malrotation, imperforate/anteriorly displaced anus and congenital diaphragmatic hernia and short stature (in absence of any endocrine or metabolic cause) and patellar anomalies. 5 identified biallelic pathogenic variants in the CDC45 gene in patients with a recurrent phenotype ( Table 1 ) they reported to be consistent with Meier-Gorlin syndrome (MGS, MIM 224690), a rare autosomal recessive primordial dwarfism disorder, characterized by microtia, short stature, and absent or hypoplastic patellae. Importantly, we suggest that a pathogenic variant in CDC45 should now be considered in every patient with a 22q11.2 deletion who presents with the following findings: craniosynostosis, anorectal anomalies/intestinal malrotation, short stature, upper limb anomalies, and cleft lip and palate. cache = ./cache/cord-010564-7c9h16bi.txt txt = ./txt/cord-010564-7c9h16bi.txt === reduce.pl bib === id = cord-010786-w3kjc6so author = Ghaderi, Sara title = Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway date = 2019-12-23 pages = extension = .txt mime = text/plain words = 3524 sentences = 180 flesch = 38 summary = title: Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway We conducted a population-based registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. We aim to examine risk of acute hospitalization among MS patients up to 3 months following influenza infection and pandemic vaccination in a large population-based cohort consisting of 6755 MS patients using nationwide populationbased Norwegian registries. We applied the self-controlled case series (SCCS) method to estimate incidence rate ratios (IRRs) of acute hospitalization with MS diagnosis in various risk periods following a diagnosis of influenza infection or vaccination, compared with a background period [22] . In model III, the IRR of acute hospitalization among patients was estimated following a diagnosis of seasonal influenza infection in the period from 1st of January, 2008 through 15st May, 2014, excluding the pandemic season (from September 2009-May 2010). cache = ./cache/cord-010786-w3kjc6so.txt txt = ./txt/cord-010786-w3kjc6so.txt === reduce.pl bib === id = cord-010398-5wot7tix author = Clauw, Daniel J. title = Perspectives on Fatigue from the Study of Chronic Fatigue Syndrome and Related Conditions date = 2010-05-31 pages = extension = .txt mime = text/plain words = 10753 sentences = 454 flesch = 40 summary = Also, these terms are consistent with the views held by practitioners who treat these patients and researchers who study them that CFS/ICF is a very heterogeneous disorder that, like many other chronic medical illnesses (eg, hypertension, diabetes), has a multiplicity of etiologic and pathogenic factors that contribute to the expression of the syndrome [12, 13] . There is now unanimity that at least a large subset of patients with CFS have a condition that is much broader than just CFS and has been labeled variously, including "functional somatic syndromes," "medically unexplained symptoms," "chronic multisymptom illnesses," "somatoform disorders," and perhaps most appropriately, "central sensitivity syndromes." Yunus [32] first showed FM to be associated with tension-type headache, migraine, and IBS; this author designed a Venn diagram in 1984 that emphasized the epidemiological and clinical overlaps between these syndromes and primary dysmenorrhea. cache = ./cache/cord-010398-5wot7tix.txt txt = ./txt/cord-010398-5wot7tix.txt === reduce.pl bib === === reduce.pl bib === id = cord-010075-72jodunj author = nan title = Paediatric SIG: Poster Session date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32008 sentences = 1913 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-010075-72jodunj.txt txt = ./txt/cord-010075-72jodunj.txt === reduce.pl bib === id = cord-010460-pczs9alv author = Caruso, Thomas J. title = Retrospective Review of the Safety and Efficacy of Virtual Reality in a Pediatric Hospital date = 2020-04-10 pages = extension = .txt mime = text/plain words = 3801 sentences = 200 flesch = 43 summary = Secondary objectives were to characterize the efficacy of VR in enhancing patient cooperation, describe the integration of VR into Child Life services, and identify interventions that accompanied VR. Secondary objectives of the study were to analyze VR efficacy in enhancing patient cooperation, describe the integration of VR into Child Life services throughout a pediatric hospital, and identify the frequency with which CCLS paired other interventions with VR. The Chariot Program and CCLS collaborated with the hospital information services (IS) department to develop customized child life intervention notes in the EMR. CCLS also documented which coping interventions the patient underwent, including family presence, comfort positioning, diaphragmatic breathing, environmental adaptions, imagery, pharmacologic assistance, tablet, bedside entertainment theater, 25 VR, augmented reality, interactive video game, and/or movie. In the exploratory VR analysis, patients were more likely to be cooperative after receiving a VR coping intervention (with or without accompanying interventions) (99.5%, n = 212, 95% CI 97.4%-100%) compared to preintervention (96.7%, n = 206, 95% CI 93.4%-98.4%, P = 0.041). cache = ./cache/cord-010460-pczs9alv.txt txt = ./txt/cord-010460-pczs9alv.txt === reduce.pl bib === id = cord-011093-d9dbvbcy author = Orange, Jordan S. title = How I Manage Natural Killer Cell Deficiency date = 2019-11-22 pages = extension = .txt mime = text/plain words = 8253 sentences = 339 flesch = 45 summary = Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient's clinical immunodeficiency. In order to be as clear as possible: NKD is a subset of PID in which the NK cell abnormality represents the major immunological defect resulting in the clinical immunodeficiency. As delineated above an example of this broader subset of PIDs that include an impact upon NK cells is NK -SCID, where the lack of NK cells is potentially relevant but not the major immunological defect causing clinical immunodeficiency. That said, to be an NKD, again the NK cell abnormality must represent the primary immunological defect presumably leading to the patient's clinical immunodeficiency. A patient with a known PID who also has abnormal NK cell numbers or functional tests should similarly not be labeled as having an NKD. cache = ./cache/cord-011093-d9dbvbcy.txt txt = ./txt/cord-011093-d9dbvbcy.txt === reduce.pl bib === id = cord-010921-yzv43e8l author = Kaye, Alan David title = Dexmedetomidine in Enhanced Recovery After Surgery (ERAS) Protocols for Postoperative Pain date = 2020-04-02 pages = extension = .txt mime = text/plain words = 7253 sentences = 431 flesch = 44 summary = As such, dexmedetomidine is now being used as part of ERAS protocols along with regional nerve blocks and other medications, to create a satisfactory postoperative outcome with reduced opioid consumption in the Post anesthesia care unit (PACU). This manuscript will comprehensively discuss dexmedetomidine with regards to postoperative pain management, ERAS protocols, pharmacokinetics, pharmacodynamics, cardiovascular and respiratory effects, toxicity, drug interactions, abuse and dependence. Analgesia with non-opioids analgesics like dexmedetomidine are being used as part of an ERAS protocol intraoperatively, along with regional nerve blocks to attain a satisfactory postoperative outcome with reduced requirements of opioids in PACU in the pediatric population. In a 2015 meta-analysis, although dexmedetomidine reduced pain intensity, opioid consumption, and postoperative nausea and vomiting (PONV), it had no effect on recovery time [29] . Postoperative pain control after the use of dexmedetomidine and propofol to sedate patients undergoing ankle surgery under spinal anesthesia: a randomized controlled trial cache = ./cache/cord-010921-yzv43e8l.txt txt = ./txt/cord-010921-yzv43e8l.txt === reduce.pl bib === id = cord-010566-tciwtxud author = Singh, Nina title = Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality date = 1998 pages = extension = .txt mime = text/plain words = 3672 sentences = 182 flesch = 40 summary = Determinants of outcome and the utility of the Child-Pugh score and the acute physiology and chronic health evaluation (APACHE) II score as predictors of outcome were prospectively assessed in 54 consecutive patients with cirrhosis requiring intensive care unit (ICU) management. 9,10 Acute physiology and chronic health evaluation (APACHE) scores were determined to be of prognostic significance in a study in ICU patients with cirrhosis; however, neither Child-Pugh scores nor etiology of liver disease were assessed in that study. 35 Mental status has been shown to be a significant predictor of outcome in ICU patients in a number of clinical settings, e.g., patients with acute renal failure requiring dialysis and transplant recipients. Although Child-Pugh scores, serum bilirubin, creatinine, or the incidence of gastrointestinal bleeding was not different, the patients with liver disease not caused by alcohol may have been more debilitated, as indicated by a significantly greater requirement for mechanical ventilation and a higher incidence of pulmonary infiltrates. cache = ./cache/cord-010566-tciwtxud.txt txt = ./txt/cord-010566-tciwtxud.txt === reduce.pl bib === id = cord-011533-im78xwl8 author = Gloude, Nicholas J. title = Thinking Beyond HLH: Clinical Features of Patients with Concurrent Presentation of Hemophagocytic Lymphohistiocytosis and Thrombotic Microangiopathy date = 2020-05-23 pages = extension = .txt mime = text/plain words = 4879 sentences = 262 flesch = 37 summary = MODS was diagnosed when a patient had symptoms of HLH/TMA and dysfunction of two or more organ systems: renal failure requiring renal replacement therapy (RRT) or cystatin C glomerular filtration rate (GFR) < 50 mL/min, invasive or non-invasive positive pressure ventilator support for > 24 h, diagnosis of pulmonary hypertension (as determined by echocardiogram and cardiology consultation), serositis (pleural or pericardial effusions), severe hypertension requiring either ≥ 2 medications or continuous infusion of an antihypertensive for > 12 h to maintain blood pressure < 99% for age, CNS symptoms (seizures, bleeding, posterior reversible encephalopathy syndrome (PRES), or altered mental status), or gastrointestinal symptoms (ileus and/or bleeding) [20] [21] [22] [23] [24] . We observed a high incidence of clinically significant complement-mediated thrombotic microangiopathy (TMA) associated with multi-organ injury in children and young adults with a diagnosis of HLH. cache = ./cache/cord-011533-im78xwl8.txt txt = ./txt/cord-011533-im78xwl8.txt === reduce.pl bib === id = cord-011360-1n998win author = Zloto, Keren title = Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery date = 2019-11-15 pages = extension = .txt mime = text/plain words = 3404 sentences = 174 flesch = 42 summary = We had reported that the level of circulating cardiac miRNA-208a following surgery can serve as a sensitive biomarker for the postoperative course of pediatric patients with CHD undergoing heart surgery for the repair of their defect [4] . Logistic regression calculations in the group of patients with oxygen saturation levels below 90% yielded a statistically significant association between the preoperative level of miRNA-208a and the risk of developing postoperative complications: the lower the level of miRNA-208a in the patient's blood before the operation, the higher was the risk for developing cardiac complications following surgery (crude OR 1.28; 95% CI 1.02-1.60; p = 0.02). The ability of preoperative levels of miRNA-208a to predict postoperative cardiac complications in the group of patients with oxygen saturation levels below 90% was studied using an ROC curve and the AUC. Our results indeed showed that high expression levels of preoperative circulating miRNA-208a were predictive of a better postoperative outcome, as reflected by fewer complications following surgery and, accordingly, were correlated with a low Aristotle score and a shorter LOH. cache = ./cache/cord-011360-1n998win.txt txt = ./txt/cord-011360-1n998win.txt === reduce.pl bib === id = cord-011413-yv4x8viu author = Shekar, Kiran title = Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date = 2020-05-12 pages = extension = .txt mime = text/plain words = 7479 sentences = 535 flesch = 41 summary = The Extracorporeal Life Support Organization (ELSO) Coronavirus Disease 2019 (COVID-19) Guidelines have been developed to assist existing extracorporeal membrane oxygenation (ECMO) centers to prepare and plan provision of ECMO during the ongoing pandemic. 11 The interim recommendations presented here balance the need to provide high-quality ECMO care to those who may benefit most while being cognizant of available resources and maintaining an environment of patient and staff safety (Figure 1) . In addition, the Extracorporeal Life Support Organization (ELSO) COVID-19 Working Group Members completed a survey on patient selection criteria for ECMO to build consensus. We recommend the following contraindications for ECMO in patients with cardiopulmonary failure due to COVID-19 (Table 1) in centers functioning under significant resource constraints, for example, Contingency Capacity ≥ Tier 1. International ECMO Network (ECMONet): Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients cache = ./cache/cord-011413-yv4x8viu.txt txt = ./txt/cord-011413-yv4x8viu.txt === reduce.pl bib === id = cord-010027-r0tl01kq author = nan title = Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland date = 2015-09-15 pages = extension = .txt mime = text/plain words = 36299 sentences = 2004 flesch = 47 summary = Further profiling of other T cell populations may help to further understand this expression which may act as a biomarker or provide a therapeutic target Biomarkers that are able to distinguish stage II and III colon cancer patients at high risk of developing disease recurrence, who may benefit from adjuvant chemotherapy, are still lacking. *AM supported by the NIHR and the Academy of Medical Sciences ABSTRACTS S·17 Assessment of HER2 Status on Needle Core Biopsy of Breast Cancer: Impact of Histopathological Concordance P M Pigera; AHS Lee; IO Ellis; EA Rakha; Z Hodi Nottingham City Hospital, Nottingham, UK One of the key recommendations introduced in the ASCO/CAP update guideline recommendation on HER2 testing is the novel concept of "histopathological concordance." It is proposed that certain tumour morphological features such as histologic type and grade should trigger repeating a molecular test in cases of "discordance". cache = ./cache/cord-010027-r0tl01kq.txt txt = ./txt/cord-010027-r0tl01kq.txt === reduce.pl bib === id = cord-011296-nutl2ovk author = Wu, Venus Kit Sze title = Prevalence, Clinical Characteristics, and Outcomes Related to Ventilator-Associated Events in Neurocritically Ill Patients date = 2020-01-23 pages = extension = .txt mime = text/plain words = 3569 sentences = 174 flesch = 38 summary = BACKGROUND: The prevalence, characteristics, and outcomes related to the ventilator-associated event(s) (VAE) in neurocritically ill patients are unknown and examined in this study. METHODS: A retrospective study was performed on neurocritically ill patients at a 413-bed level 1 trauma and stroke center who received three or more days of mechanical ventilation to describe rates of VAE, describe characteristics of patients with VAE, and examine the association of VAE on ventilator days, mortality, length of stay, and discharge to home. The main findings of this study are that (1) VAEs are prevalent among neurocritically ill patients, occur within the first week of mechanical ventilation, across age, sex, BMI, and GCS, and the rates differ among various diagnoses, (2) the most common trigger for VAE is an increase in PEEP, and (3) VAE is associated with increased time spent on mechanical ventilation but is not associated with increased in-hospital mortality or discharge to home. cache = ./cache/cord-011296-nutl2ovk.txt txt = ./txt/cord-011296-nutl2ovk.txt === reduce.pl bib === id = cord-011181-9nvwk04v author = Jakimovska, Vesna Miloshevska title = Epidemiological characteristics and early complications after spinal cord injury in Former Yugoslav Republic of Macedonia date = 2019-08-19 pages = extension = .txt mime = text/plain words = 5363 sentences = 279 flesch = 52 summary = STUDY DESIGN: Prospective cohort study OBJECTIVES: To describe epidemiological data and complications after acute traumatic spinal cord injury (tSCI) in Former Yugoslav Republic of Macedonia (FYROM). The University Clinic for Traumatology, Orthopedics, Anesthesia, Reanimation, Intensive Care Unit and Emergency Center (TOARILUC), Mother Teresa, Skopje, FYROM, is a level one trauma hospital and the only public hospital treating patients with SCI in the country. The purpose of this study was to prospectively investigate incidence, cause of injury, demography and SCI characteristics, acute phase mortality/ survival, and early complications after tSCI among patients admitted to the University Clinic for TOARILUC. The information included: demographic data (gender, age at injury, marital status, and employment status), past illnesses, addiction habits (smoking, drugs, and alcohol consumption), preadmission records from patients transported from other hospitals, type of transport to the hospital, date of admission and discharge from TOARILUC, cause and type of injury, associated injuries, and mortality. cache = ./cache/cord-011181-9nvwk04v.txt txt = ./txt/cord-011181-9nvwk04v.txt === reduce.pl bib === id = cord-011284-u4qmvz3c author = Livingston, Nicholas A. title = Addressing Diversity in PTSD Treatment: Clinical Considerations and Guidance for the Treatment of PTSD in LGBTQ Populations date = 2020-03-16 pages = extension = .txt mime = text/plain words = 5249 sentences = 207 flesch = 28 summary = However, evaluations of these interventions have failed to examine the role of LGBTQ identities in recovery from trauma, and existing PTSD treatments do not account for ongoing threat to safety or the pervasive minority stress experienced by LGBTQ patients. To begin the review of current best-practice interventions for PTSD, it is important to note that gold-standard PTSD treatments, such as PE and CPT, were not developed for non-criterion A trauma, and that debate continues regarding the appropriateness or sufficiency of these treatments in addressing the range of clinically significant experiences faced by many LGBTQ individuals (e.g., discrimination [29••] ). Given the pervasive nature of stress, stigma, and discrimination against LGBTQ people, and the concomitant high rates of trauma exposure, it is critical for health care providers to ensure cultural awareness, sensitivity, and responsiveness to the experiences and healthcare needs of this patient population. In this paper, we provided an overview of the key issues with respect to trauma, PTSD, minority stress, and evidence-based treatment for LGBTQ patients with which any health care provider should be aware. cache = ./cache/cord-011284-u4qmvz3c.txt txt = ./txt/cord-011284-u4qmvz3c.txt === reduce.pl bib === id = cord-011255-9q2frk71 author = Kippnich, Maximilian title = Dual-room twin-CT scanner in multiple trauma care: first results after implementation in a level one trauma centre date = 2020-04-25 pages = extension = .txt mime = text/plain words = 3451 sentences = 196 flesch = 57 summary = The time intervals from the arrival of a patient in the resuscitation room to the start of CT and of emergency surgery has been defined as the main quality indicator for the whole process of trauma resuscitation. For those patients, we collected the time to CT (tCT), the time to emergency surgery (tOR), the injury severity score (ISS) and outcome variables (mortality, ventilator-dependent days and length of intensive care unit (ICU) stay). A new and large-scale trauma resuscitation area with a dual-room sliding gantry CT scanner for simultaneous treatment or two multiple trauma patients by its was introduced (SOMATOM Definition Edge, Siemens Healthineers, Erlangen, Germany). Focused Fig. 1 Large-scale trauma resuscitation area with a dual-room sliding gantry CT scanner assessment with sonography for trauma (FAST) is performed only on haemodynamically unstable patients or if the 'leading group' decides to do so. Whole-body multislice computed tomography (MSCT) improves trauma care in patients requiring surgery after multiple trauma cache = ./cache/cord-011255-9q2frk71.txt txt = ./txt/cord-011255-9q2frk71.txt === reduce.pl bib === id = cord-011725-t1jl4cy1 author = Varma, Niraj title = HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date = 2020-06-11 pages = extension = .txt mime = text/plain words = 3643 sentences = 193 flesch = 38 summary = In light of the current pandemic, monitoring strategies should focus on selecting high-risk patients in need of close surveillance and using alternative remote recording devices to preserve personal protective equipment and protect health care workers from potential contagious harm. 21-23 Virtual clinics move far beyond simple telephone contacts by integrating information from photos, video, mobile heart rhythm and mobile health devices recording ECG, and remote cardiovascular implantable electronic device (CIED) interrogations. In the outpatient setting, a recent statement from the US Food & Drug Administration (FDA) "cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems." (This does not affect FDA-approved uses for malaria, lupus, and rheumatoid arthritis.) 51 Exceptions to this practice are acknowledged to occur in some regions, as these drugs have been used outside the United States without regulatory warnings. cache = ./cache/cord-011725-t1jl4cy1.txt txt = ./txt/cord-011725-t1jl4cy1.txt === reduce.pl bib === id = cord-011712-fyrbe8tw author = Venkatesan, Sudhir title = Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection date = 2020-02-01 pages = extension = .txt mime = text/plain words = 4623 sentences = 200 flesch = 40 summary = METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. CONCLUSIONS: When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment. We undertook a one-stage individual participant data (IPD) [16] meta-analysis to explore the association between NAI treatment of patients hospitalized with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) infection and the LoS during the 2009-2010 influenza pandemic. In Hong Kong, a study of 356 adult patients hospitalized with laboratory-confirmed seasonal influenza showed that early oseltamivir treatment was associated with a reduced LoS in both unadjusted and multivariable analyses [9] , compared with no or later treatment, with the median LoS decreasing from 6 to 4 days; this accords with our primary analysis. cache = ./cache/cord-011712-fyrbe8tw.txt txt = ./txt/cord-011712-fyrbe8tw.txt === reduce.pl bib === id = cord-011349-bykvn367 author = Rajasekaran, Raja Bhaskara title = Megaprosthesis in distal femur nonunions in elderly patients—experience from twenty four cases date = 2019-08-07 pages = extension = .txt mime = text/plain words = 3505 sentences = 218 flesch = 53 summary = PURPOSE OF THE STUDY: To evaluate the outcomes and complications using cemented megaprosthesis in elderly patients with distal femur nonunions (DFN). MATERIALS AND METHODS: Between 2012 and 2016, 24 patients of DFN with an average age of 71.8 years (66–83) and an average 1.9(1–3) prior surgery was managed with distal femur replacement using cemented modular endoprosthesis. CONCLUSION: By permitting immediate full weight-bearing ambulation and with most patients returning to an acceptable functional status, cemented megaprosthesis is a viable and useful single-stage management option in elderly patients with DFN. Cemented modular endoprosthetic replacement in managing DFN is a welldescribed option which enables immediate weight-bearing following surgery leading to faster recovery of geriatric patients [9] [10] [11] . This study was performed to evaluate the outcomes and complications following cemented modular distal femoral endoprosthesis used in managing DFN in elderly patients. cache = ./cache/cord-011349-bykvn367.txt txt = ./txt/cord-011349-bykvn367.txt === reduce.pl bib === id = cord-011483-zc6ve6le author = Leclerc, Angela M. title = Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients date = 2020-05-20 pages = extension = .txt mime = text/plain words = 5727 sentences = 260 flesch = 41 summary = Neurostimulant administration data were extracted from the electronic medication administration record, including medication (amantadine, modafinil, or both), starting dose, time from stroke to initiation, and whether the neurostimulant was continued at hospital discharge. Amantadine and modafinil are administered to patients following acute stroke in our intensive care unit (ICU) on an ad hoc basis, but data supporting this practice are largely limited to delayed treatment in rehabilitation or outpatient facilities with very few reports during the acute care hospitalization [17] [18] [19] . Two hundred five patients received amantadine and/ or modafinil during the 3.7 year study period and 118 patients were initially excluded: neurostimulant administered for an indication other than acute stroke (TBI [n = 50], cardiac arrest [n = 15], brain tumor [n = 6], encephalitis [n = 5], or encephalopathy [n = 4]); neurostimulant prescribed prior to hospital admission (n = 27) or administered for < 72 h (n = 8); or history of seizures (n = 3). cache = ./cache/cord-011483-zc6ve6le.txt txt = ./txt/cord-011483-zc6ve6le.txt === reduce.pl bib === id = cord-011297-4um9w2dx author = Brunker, Lucille title = New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report date = 2019-11-28 pages = extension = .txt mime = text/plain words = 2954 sentences = 147 flesch = 38 summary = Despite treatment with multiple anti-epileptic drugs in addition to IV anesthetics, burst suppression was initially unsustainable and the patient remained in super-refractory status epilepticus. Clinical response with a goal of 1–2 bursts per screen on EEG monitor was eventually achieved after a course of rituximab and plasma exchange therapy as well as a 7-day barbiturate coma with a regimen of clobazam, lacosamide, Keppra, and oxcarbazepine followed by a slow taper of phenobarbital and the addition of fosphenytoin. We discuss treatment strategies for new-onset refractory status epilepticus and highlight the role of rapid initiation of burst suppression with high-dose IV anesthetics to ensure neuroprotection while the underlying etiology is addressed with immune-modulating therapy. A midazolam infusion was initiated and up-titrated to 60 mg h −1 but failed to achieve burst suppression, and the patient continued to have generalized epileptic discharges on EEG. cache = ./cache/cord-011297-4um9w2dx.txt txt = ./txt/cord-011297-4um9w2dx.txt === reduce.pl bib === id = cord-011975-8vl45xb7 author = Keser, Tobias title = Risk Factors for Dysphagia and the Impact on Outcome After Spontaneous Subarachnoid Hemorrhage date = 2019-11-15 pages = extension = .txt mime = text/plain words = 3806 sentences = 195 flesch = 41 summary = BACKGROUND: Despite the tremendous impact of swallowing disorders on outcome following ischemic stroke, little is known about the incidence of dysphagia after subarachnoid hemorrhage (SAH) and its contribution to hospital complications, length of intensive care unit stay, and functional outcome. The main goal of the current study was (1) to quantify the rate of swallowing disorders after SAH by using a simple clinical assessment tool, (2) to identify early predictors of dysphagia in all severity grades of SAH patients, and (3) to evaluate how dysphagia contributes to hospital complications, length of ICU stay, and poor outcome. CT computed tomography, EVD external ventricular drain, ICU intensive care unit, IQR interquartile range Statistical analysis was performed using the Wilcoxon rank-sum test (*), the Chi-square test ( †), and the linear-by-linear association test for trend ( ‡) Although it is well known that the high incidence of swallowing disorders after ischemic stroke contributes to impaired quality of life and poor functional outcome, only few studies report the incidence of dysphagia following SAH [9, 10] . cache = ./cache/cord-011975-8vl45xb7.txt txt = ./txt/cord-011975-8vl45xb7.txt === reduce.pl bib === id = cord-010088-s9tfvtao author = nan title = Oral Abstracts date = 2013-11-01 pages = extension = .txt mime = text/plain words = 43522 sentences = 2257 flesch = 49 summary = These include 'incorrect blood component transfused' events, where the blood component was intended for another recipient (frequently due to errors in patient identification at the time of collection of the pre-transfusion sample, or at the time of bedside administration), or did not meet the patient's special needs (such as a patient with a red cell antibody who did not receive the required antigen-negative unit). Methods: Eligibility criteria for inclusion in the study included the following: transfusion of Rh D positive platelets, no anti D detectable before transfusion, no previous exposure to Rh D positive blood components, and results of follow-up testing of anti-D in patients serum available. In addition, the allelic frequency of Hpdel was calculated to be 0.015 by a genetic study of a limited number of the Japanese individuals, suggesting that Hp deficiency might distribute among the Japanese population as a phenotype of serum Hp. Aims: In this report, we present the results obtained from a hemovigilance survey carried out between 1998 and 2012, in which Hp deficiency was identified among Japanese patients who had experienced nonhemolytic TRs (NHTRs), and those obtained from a screening of Hp-deficient Japanese healthy blood donors. cache = ./cache/cord-010088-s9tfvtao.txt txt = ./txt/cord-010088-s9tfvtao.txt === reduce.pl bib === id = cord-011512-gw2sk90q author = Houlston, E. title = A simple pleasure date = 2020-05-22 pages = extension = .txt mime = text/plain words = 1933 sentences = 84 flesch = 54 summary = Sir, the British Orthodontic Society (BOS) and the Oral Health Foundation have recently collaboratively launched a muchawaited campaign, Safe Brace Campaign, alerting the public to the dangers of direct to consumer orthodontics, also known as 'DIY Braces' (www.safebrace.org). Sir, to determine the use and perceived benefit of webinars and online learning, a brief survey was sent to dentists across the UK; 50 responses were received from a mix of those working in general dental practice, hospital and community. 2 The calming and stress reducing effects of listening to music have been widely studied and this simple and cost-effective method of relaxation is something easily accessible to all members of the dental team. Sir, as a DCT3 in Oral Surgery I have seen several patients referred for removal of teeth under general anaesthetic (GA) due to dental anxiety. Experience of listening to music on patient anxiety during minor oral surgery procedures: a pilot study cache = ./cache/cord-011512-gw2sk90q.txt txt = ./txt/cord-011512-gw2sk90q.txt === reduce.pl bib === id = cord-012025-faj682bp author = Savioli, Felicio title = Coagulation profile in severe COVID-19 patients: what do we know so far? date = 2020 pages = extension = .txt mime = text/plain words = 810 sentences = 62 flesch = 38 summary = (7) assessed the coagulation profile and outcomes of 449 severe COVID-19 patients. (8) Moreover, a negative D-dimer test could be used for decision-making on anticoagulation therapy discontinuation in venous thromboembolism patients, however, this approach remains arguable and additional studies are required to validate this proposal. (10) The diagnosis of DIC in critically ill patients is made by standard coagulation tests, which can only determine a 5% of thrombin generation and are not suitable to discriminate patients with prothrombotic states from those with increased risk of bleeding. For the present time, we suggest that additional studies should be performed focusing on coagulation testing, to provide a better understanding of the coagulation profile in severe COVID-19 patients, improve the assessment of coagulation-related risks, and support decisions on the appropriated anticoagulation therapy. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy cache = ./cache/cord-012025-faj682bp.txt txt = ./txt/cord-012025-faj682bp.txt === reduce.pl bib === id = cord-011649-3dlsy8fl author = Limoncelli, Janine title = General Anesthesia Recommendations for Electroconvulsive Therapy During the Coronavirus Disease 2019 Pandemic date = 2020-06-12 pages = extension = .txt mime = text/plain words = 1636 sentences = 80 flesch = 44 summary = 2 Early guidance from the Anesthesia Patient Safety Foundation and other sources regarding airway management in COVID-19positive patients has recommended rapid sequence intubation and avoidance of mask ventilation to reduce the risk of droplet spread and aerosolization of virus. 3 Given the penetrance of COVID-19 in the New York metropolitan area, the Weill Cornell Medicine NewYork-Presbyterian Hospital Anesthesiology and Psychiatry departments collaborated to develop guidelines to ensure that the patients who were in urgent need of ECTwere provided that care while minimizing exposure to the staff and potential spread of disease to other ECT patients. Whereas anesthesia for ECT had been performed by a single anesthesiologist in the past, the donning and doffing of PPE in addition to the necessity of ensuring complete mask fit if positive pressure ventilation is used require 2 anesthesia providers to be available at all times. cache = ./cache/cord-011649-3dlsy8fl.txt txt = ./txt/cord-011649-3dlsy8fl.txt === reduce.pl bib === id = cord-012117-c693oefo author = Diaz-Padilla, Ivan title = A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors date = 2013-10-01 pages = extension = .txt mime = text/plain words = 4691 sentences = 273 flesch = 49 summary = Dose-limiting toxicities (DLTs) were defined as adverse events (AEs) as least possibly related to study medication(s) and fulfilling one of the following criteria: a) grade 3 or 4 neutropenia complicated by fever ≥38.5°C, or grade 4 neutropenia of at least 7 days duration; b) grade 3 thrombocytopenia complicated by hemorrhage or grade 4 thrombocytopenia; or c) any grade 3 or higher non-hematologic toxicity (except anorexia, nausea, vomiting, and diarrhea that was not optimally controlled with appropriate medical intervention); d) any ≥grade 3 electrolyte abnormality including hypophosphatemia, hypocalcemia, or hypomagnesemia that did not resolve within 72 h with appropriate therapy or if it was associated with new ECG changes; e) treatment-related toxicities that resulted in failure to receive at least 75 % of the planned doses of RO4929097 and of temsirolimus despite maximal supportive care measures; f) inability to resume dosing for cycle 2 at the current dose level within 14 days due to treatment-related toxicity. cache = ./cache/cord-012117-c693oefo.txt txt = ./txt/cord-012117-c693oefo.txt === reduce.pl bib === id = cord-011221-rhyxp4v5 author = Fu, Chih-Yuan title = Obesity is Associated with Worse Outcomes Among Abdominal Trauma Patients Undergoing Laparotomy: A Propensity-Matched Nationwide Cohort Study date = 2019-11-11 pages = extension = .txt mime = text/plain words = 2497 sentences = 153 flesch = 47 summary = title: Obesity is Associated with Worse Outcomes Among Abdominal Trauma Patients Undergoing Laparotomy: A Propensity-Matched Nationwide Cohort Study Patients who received laparotomies were analyzed using propensity score matching (PSM) to evaluate the mortality rate and LOS between obese and non-obese patients. In this study, a nationwide analysis was performed using the NTDB to evaluate the role of obesity in abdominal trauma patients who required laparotomies. However, there was no significant difference in mortality rate, hospital LOS, or ICU LOS between the SBP systolic blood pressure, ED emergency department, RR respiratory rate, GCS Glasgow coma scale, ISS injury severity score, BMI body mass index, CI confidence interval obese and non-obese in patients who did not receive laparotomy after matching (Table 3 ). Obesity is associated with increased mortality and LOS in abdominal trauma patients who received laparotomies versus those who did not. cache = ./cache/cord-011221-rhyxp4v5.txt txt = ./txt/cord-011221-rhyxp4v5.txt === reduce.pl bib === id = cord-012115-hpsxi9ay author = Archie, Patrick title = Music-based interventions in palliative cancer care: a review of quantitative studies and neurobiological literature date = 2013-05-30 pages = extension = .txt mime = text/plain words = 6729 sentences = 279 flesch = 38 summary = The Cochrane Library, Ovid, PubMed, CINAHL Plus, PsycINFO, and ProQuest were searched for the subject headings music, music therapy, cancer, oncology, palliative care, pain, anxiety, depression, mood, quality of life, prevalence, neuroscience, functional imaging, endogenous opioids, GABA, 5HT, dopamine, and permutations of these same search terms. RESULTS: Available evidence suggests that music-based interventions may have a positive impact on pain, anxiety, mood disturbance, and quality of life in cancer patients. b Inferior view of neuroanatomic regions affected by music (and implicated in the pathophysiology of pain, anxiety, and/or depression) outcome to cancer patients in palliative care settings, future studies investigating the effect of music-based interventions on pain, anxiety, or mood disturbance in this patient population should incorporate QOL measurements into their outcome assessment. cache = ./cache/cord-012115-hpsxi9ay.txt txt = ./txt/cord-012115-hpsxi9ay.txt === reduce.pl bib === id = cord-011188-59hn9wsv author = Bruce, Lori title = A Pot Ignored Boils On: Sustained Calls for Explicit Consent of Intimate Medical Exams date = 2020-03-09 pages = extension = .txt mime = text/plain words = 8933 sentences = 434 flesch = 45 summary = This paper refutes the main arguments in favor of the status quo, identifies a series of harms related to continuing the current practice, and proposes an explicit consent policy for intimate exams along with specific changes to medical school curriculum and institutional culture. Recent surveys and reports reveal that some physicians and medical students still conduct unconsented intimate exams (UIEs) on male and female patients. Patients and members of the general public are often shocked to learn that physicians and medical students may perform intimate exams on them without explicit consent and believe such exams meet the criteria for battery, malpractice, or sexual assault. Interestingly, Ubel, a physician who examined UIE practices in teaching hospitals in a 2003 survey of 401 medical students, found that completion of the obstetrics/gynecology clerkship is associated with decreased interest in informed consent (Ubel 2003) . cache = ./cache/cord-011188-59hn9wsv.txt txt = ./txt/cord-011188-59hn9wsv.txt === reduce.pl bib === id = cord-011793-hlktpla4 author = Rice, Todd W. title = In Defense of Evidence-based Medicine for the Treatment of COVID-19 Acute Respiratory Distress Syndrome date = 2020-07-17 pages = extension = .txt mime = text/plain words = 1828 sentences = 81 flesch = 42 summary = Although the desire to try to treat these patients with already approved drugs is understandable, what is less understandable is the desire in medical publications and on social media to abandon the principles of evidence-based critical care that we have established over the last 3 decades (9), because "I have never seen patients with ARDS act like this." Large, well-designed, multicenter randomized trials have set the foundation of an evidence-based practice of how to produce the best outcomes for critically ill patients. Instead, improved outcomes are seen through understanding and implementing best practices derived via strong scientific evidence generated from well-designed randomized controlled trials into the routine care of critically ill patients. Maintaining other principles of good critical care, as demonstrated in large, multicenter randomized trials, will also improve outcomes in these critically ill patients with COVID-19, even if "COVID-19 is completely different from other intensive care unit syndromes." Conservative fluid management once out of shock and without renal failure increases time alive and free from ventilation (15) . cache = ./cache/cord-011793-hlktpla4.txt txt = ./txt/cord-011793-hlktpla4.txt === reduce.pl bib === id = cord-011062-ukz4hnmy author = nan title = Poster date = 2020-03-11 pages = extension = .txt mime = text/plain words = 88313 sentences = 5669 flesch = 55 summary = Ming-Yueh Chou 1,3 , Ying-Hsin Hsu 1 , Yu-Chun Wang 1 , Chih-Kuang Liang 1,3 , Li-Ning Peng 2,4 , Liang-Kung Chen 2,4 , Yu-Te Lin 1 ((1) Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; (2) Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan; (3) Department of Geriatric Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan; (4) Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan) Background: Older people with frailty are at risk of adverse outcomes, such as falls, functional decline and mortality, and multi-domain intervention program may prevent those. Conclusion: Our study showed that a multicomponent exercise program is effective for posthospitalization patients because after 24-week intervention there were significant reductions in frailty and improving results in muscle strength and physical performance. Methods: Cross-sectional analysis of 757 communitydwelling older adults who completed multi-domain geriatric screen assessing for social vulnerability, mood, cognition, functional performance, nutrition, physical frailty (FRAIL) and sarcopenia (SARC-F). cache = ./cache/cord-011062-ukz4hnmy.txt txt = ./txt/cord-011062-ukz4hnmy.txt === reduce.pl bib === id = cord-010933-xuztu95a author = Davis, Samuel title = Theoretical bounds and approximation of the probability mass function of future hospital bed demand date = 2018-11-06 pages = extension = .txt mime = text/plain words = 5975 sentences = 271 flesch = 48 summary = Uncertainty in patient resource demand is caused by several stochastic processes, including the number and timing of arrivals and discharges, length of stay (LOS), unit transfers, health improvement and deterioration, surgical complications, and same-day cancellations for outpatient and surgical appointments. Developing and applying an accurate model to forecast patient resource demand for multiple time periods into the future improves both the cost and safety of providing care when coupled with an adaptive staffing strategy. Most models make simplifying assumptions to manage tractability and fit data availability, including assuming stationary or cyclic demand patterns [16, 17, 36] , exponential-based inter-arrival times and LOS distributions [17, 36, 48, 49] , patient homogeneity [10, 31, 36] , singleday forecasts [47] , and point estimates instead of probability mass functions (PMFs) [14, 31] . The goal of this study is to forecast an accurate approximation for the multi-period PMF of bed demand using the exact surgical schedule at the time of the forecast, non-stationary inter-arrival times, and patient-level duration-varying LOS distributions. cache = ./cache/cord-010933-xuztu95a.txt txt = ./txt/cord-010933-xuztu95a.txt === reduce.pl bib === id = cord-011103-sstpidvk author = Younan, Duraid title = Factors Predictive of Ventilator-associated Pneumonia in Critically Ill Trauma Patients date = 2019-11-26 pages = extension = .txt mime = text/plain words = 2391 sentences = 111 flesch = 46 summary = CONCLUSIONS: Among critically ill trauma patients, acute kidney injury, injury to the spine, face or sternum, massive transfusion and intensive care unit length of stay were associated with VAP. Variables collected from the patients' medical records and trauma database included age, race, gender (demographics), presenting vital signs, injury type and severity, the presence of ventilator-associated pneumonia, hospital and intensive care unit length of stay and survival data. We found that, among critically ill trauma patients admitted to the intensive care unit, injury to the spine, face or sternum, massive transfusion, acute kidney injury and intensive care unit length of stay were associated with ventilator-associated pneumonia (VAP). Among critically ill trauma patients admitted to the intensive care unit, acute kidney injury, injury to the spine, face or sternum, massive transfusion and intensive care unit length of stay were associated with VAP. cache = ./cache/cord-011103-sstpidvk.txt txt = ./txt/cord-011103-sstpidvk.txt === reduce.pl bib === id = cord-012459-tge08va0 author = Matthews, Laura J. title = Airway Alert Bracelets: Enhancing Safety in the Coronavirus Disease 2019 Era date = 2020-08-18 pages = extension = .txt mime = text/plain words = 626 sentences = 35 flesch = 51 summary = We have designed a medical alert bracelet, similar to a hospital name band, that is placed on any patient where nonstandard equipment (anything other than iView video laryngoscope [Intersurgical, Wokingham, England] plus bougie) was needed to secure the airway or where the person intubating experienced difficulty. They then remain on the patient's wrist for the duration of their ICU stay and provide a visual alert of their difficult airway, regardless of the bed space or even hospital if they are transferred for ongoing care (Figure) . The presence of this bracelet on a patient prompts a review of the electronic intubation notes before undertaking any procedure where the airway could be "at risk," and appropriate measures to be put in place-for example, a senior anesthetist with the relevant equipment present when airway alert patients are proned or deproned. Airway Alert Bracelets: Enhancing Safety in the Coronavirus Disease 2019 Era Figure. cache = ./cache/cord-012459-tge08va0.txt txt = ./txt/cord-012459-tge08va0.txt === reduce.pl bib === id = cord-012037-9kmul7he author = Veenis, J. F. title = Remote monitoring of chronic heart failure patients: invasive versus non-invasive tools for optimising patient management date = 2019-11-19 pages = extension = .txt mime = text/plain words = 4452 sentences = 208 flesch = 39 summary = Recently, the CardioMEMS device (Abbott Inc., Atlanta, GA, USA), an implantable haemodynamic remote monitoring sensor, has shown promising results in preventing HF-related hospitalisations in chronic HF patients hospitalised in the previous year and in New York Heart Association functional class III in the United States. Multiple studies have investigated the remote monitoring abilities of implantable cardioverter defibrillator/cardiac resynchronisation therapy (ICD/CRT) devices in chronic HF patients to improve HF-related hospitalisation rates (Tab. 2). The IN-TIME RCT showed that using the remote monitoring abilities of the ICD and CRT devices leads to a reduction of a combined endpoint of all-cause death, overnight HF-related hospitalisation, change in New York Heart Association (NYHA) class, and change in patient global self-assessment [19] . In this trial, NYHA class III/IV chronic HF patients were included and investigated as to whether remote haemodynamic monitoring using the ePAD could reduce HF-related hospitalisation, emergency or urgent care visits requiring intravenous therapy. cache = ./cache/cord-012037-9kmul7he.txt txt = ./txt/cord-012037-9kmul7he.txt === reduce.pl bib === id = cord-011327-zsoc4wec author = Martin-Loeches, Ignacio title = Antibiotic prophylaxis in the ICU: to be or not to be administered for patients undergoing procedures? date = 2019-11-28 pages = extension = .txt mime = text/plain words = 1973 sentences = 95 flesch = 27 summary = However, SAP is also commonly practiced in many ICUs. A single-centre study conducted recently in a Belgian ICU showed that SAP and prophylaxis for immunocompromised patients constituted two-thirds of prophylactic antibiotic treatments prescribed [13] . There are no randomised controlled trials on the effects of timing or choice of antibiotic prophylaxis on the outcomes of ICU patients requiring unplanned surgical procedures. However, French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU suggest consideration of selective digestive decontamination with both topical and systemic antibiotics (for a maximum of 96 h) to decrease the rate of pneumonia immediately after urgent intubation based on indirect evidence from several studies [22] . A metaanalysis of studies focused on antibiotic prophylaxis for chest drain insertion in non-ICU patients (i.e. thoracic injury), concluded that treatment after chest drain insertion was significantly associated with a reduced risk of empyema (RR 0.25; 95% CI 0.13-0.49) and pneumonia (RR 0.41; 95% CI 0.24-0.71) when compared with placebo alone [28] . cache = ./cache/cord-011327-zsoc4wec.txt txt = ./txt/cord-011327-zsoc4wec.txt === reduce.pl bib === id = cord-011302-pfepyvaw author = Edlmann, Ellie title = The changing face of neurosurgery for the older person date = 2020-04-25 pages = extension = .txt mime = text/plain words = 3889 sentences = 180 flesch = 43 summary = In this review, we consider changes in practice and current treatment outcomes in older patients with aneurysmal subarachnoid haemorrhage, traumatic head injury, and haemorrhagic strokes. A recent systematic review of endovascular treatment of ruptured aneurysms in patients aged over 65 reported good outcomes in 66%, with a mortality rate of around 26% at 1 year [36] . Koffijberg analysed the cost-effectiveness of treating ruptured aneurysms in patients aged over 70, identifying key parameters including patient age (and thus life expectancy), good or poor clinical condition on presentation, conservative or occlusive treatment (clipping or coiling) and good or poor outcomes [18] . This is supported by collaborations such as IMPACT (International Mission for Prognosis and Analysis of Clinical Trials in TBI) and CRASH (Corticosteroid Randomisation After Significant Head injury), who have used available evidence to develop prognostic calculators for TBI, where age is a corestratifying component and significantly increases chances of a poor outcome [17, 38] . cache = ./cache/cord-011302-pfepyvaw.txt txt = ./txt/cord-011302-pfepyvaw.txt === reduce.pl bib === id = cord-012665-fflye8a3 author = Marques-Vidal, Pedro title = Statistical issues regarding the article by Liu et al. date = 2020-09-02 pages = extension = .txt mime = text/plain words = 241 sentences = 29 flesch = 82 summary = key: cord-012665-fflye8a3 title: Statistical issues regarding the article by Liu et al. cord_uid: fflye8a3 I read with interest the article by Liu et al. [1] on the effect of malnutrition status among elderly patients with COVID-19. I have some questions regarding the analysis of the data. • For each patient, four nutritional risk scores were computed. Comparing the prevalence of "at risk" patients between scores cannot be performed by simple chi-square, as the data come from the same sample (i.e., the data is not independent). It seems that the authors computed the OR for the non-at risk patients. Recomputing the OR leads to a value of 9.80, which is more compatible with the effects of malnutrition on increased LOS. • I am surprised that p values of zero are presented. Clinical significance of nutritional risk screening for older adult patients with COVID-19 cache = ./cache/cord-012665-fflye8a3.txt txt = ./txt/cord-012665-fflye8a3.txt === reduce.pl bib === id = cord-012778-yr8zuvw9 author = Zhang, Lei title = Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China date = 2019-08-06 pages = extension = .txt mime = text/plain words = 5055 sentences = 262 flesch = 46 summary = We quantified the time course of PSP improvement in patients after treatment with these three antipsychotics: olanzapine, risperidone, and aripiprazole reached an E(max) value of 80.3%, 68.2%, and 23.9% at weeks 56.7, 29.2, and 36.8, respectively. In addition, quantitative information on the long-term social functioning of schizophrenic patients treated with SGAs is scarce in current clinical practice [12, 13] , and the available information does not reflect the differences in therapeutic efficacies between various drugs. Using data from the Study of Long-term Outcomes for Schizophrenia by Atypical Antipsychotic Treatment in China (SALT-C) study, which is a multicenter, real-world clinical study, we examined the differences in efficacy between three antipsychotics (olanzapine, risperidone, and aripiprazole) to provide a guide for clinicians when choosing an antipsychotic for the individualized treatment of schizophrenia. The SALT-C study was registered at https://www.clinicaltrials.gov (identifier: NCT02640911) and produced a large data set of real-world schizophrenia patients in China recruited in an open-label 3-year follow-up clinical trial of widely used atypical antipsychotics. cache = ./cache/cord-012778-yr8zuvw9.txt txt = ./txt/cord-012778-yr8zuvw9.txt === reduce.pl bib === id = cord-011875-ga0dzj3v author = Tsolaki, Vasiliki title = Are Patients with COVID-19 Dying of or with Cardiac Injury? date = 2020-07-15 pages = extension = .txt mime = text/plain words = 1306 sentences = 79 flesch = 44 summary = Indeed, they quote a sentence in which Dr. Laghi and I say that physicians do not initiate mechanical ventilation consequent to "slotting a patient into a particular diagnostic pigeonhole." (2) Dr. Modesto-Alapont and colleagues claim that the Berlin definition enhances the ability to make a precise diagnosis of acute respiratory distress syndrome (ARDS) in patients with coronavirus disease (COVID-19). Cardiac involvement probably complicates severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients, but the true incidence (considering specific echocardiographic findings) and the attributable mortality are aspects not yet well clarified. Very few reports have used echocardiographic criteria beyond biomarkers to diagnose cardiac injury, but none have differentiated between myocarditis, cardiomyopathy (stress or septic), ACS, and acute heart failure in the era of COVID-19. In a recent report involving 416 hospitalized patients from Wuhan, 19.7% presented with "acute myocardial injury." The diagnosis relied on increased cardiac biomarker (hypersensitive troponin I) levels, regardless of the electrocardiographic and echocardiographic findings (3). cache = ./cache/cord-011875-ga0dzj3v.txt txt = ./txt/cord-011875-ga0dzj3v.txt === reduce.pl bib === id = cord-013035-7sfj0czv author = Savinelli, Stefano title = Reply date = 2020-09-20 pages = extension = .txt mime = text/plain words = 1259 sentences = 67 flesch = 41 summary = We read with great interest the article by McCarthy et al., 1 regarding the favourable use of tocilizumab in a series of patients presenting with cytokine storm related to coronavirus disease 2019 (COVID-19) infection. Reducing short-term mortality from cytokine release syndrome may come at the expense of long-term fatality rate, due to secondary healthcare or ventilator-associated bacterial or fungal infections, especially in critically ill patients with increased length of hospitalization in intensive care units (ICU). However, observational studies demonstrate favourable outcomes regarding mortality and risk of proceeding to endotracheal intubation when IL-6RA are used in a pre-critical (pre-intensive care unit (ICU)) setting, such as that described in our report, before the onset of severe respiratory failure. To address these questions, our group has designed a phase 2, open-label, two-stage, multicentre, randomized trial comparing different doses of single-dose administration of tocilizumab in adults with severe, non-critical, COVID-19 with evidence of hyperinflammatory state. cache = ./cache/cord-013035-7sfj0czv.txt txt = ./txt/cord-013035-7sfj0czv.txt === reduce.pl bib === id = cord-013149-y0dbhtef author = Wohlfarth, P. title = Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date = 2020-10-12 pages = extension = .txt mime = text/plain words = 2333 sentences = 260 flesch = 35 summary = Timing der Intensivstationsaufnahme Die vorhandenen Daten über kritisch kranke Krebspatienten mit den häufigsten Intensivstationsaufnahmegründen, ARV und Sepsis, zeigen einmütig, dass eine möglichst frühzeitige Verlegung auf die Intensivstation, also bei manifestem oder eventuell auch nur drohendem Organversagen, erfolgen sollte [8, 9] . Bei Patienten mit "chronic obstructive pulmonary disease" (COPD) und hypertensivem Lungenödem stellt die nichtinvasive Beatmung (NIV) den Goldstandard der Therapie dar und es gibt keine evidenzbasierte Rationale, dass dies nicht auch bei Krebspatienten gelten sollte. These include defining proper goals of intensive care treatment, managing acute respiratory failure with diverse differential considerations, treating immunologic side-effects of ever new and innovative cancer therapies, as well as numerous clinical scenarios which may exclusively arise in cancer patients. Cancer · Intensive care unit · Acute respiratory failure · Immunotherapy · iCHOP und womöglich "um jeden Preis" nicht zu intubieren, kann somit als überholt, ja im Fall sekundärerIntubationenbeiNIV-Versagen sogar als potenziell gefährlich angesehen werden. cache = ./cache/cord-013149-y0dbhtef.txt txt = ./txt/cord-013149-y0dbhtef.txt === reduce.pl bib === id = cord-012469-6cvu5umd author = Lewis, Jayne title = Speaking with Frankenstein date = 2020-08-21 pages = extension = .txt mime = text/plain words = 8505 sentences = 414 flesch = 54 summary = As a professor of literature and a professor of medicine, we are especially interested in what it might mean to "speak with" Victor Frankenstein and his Creature because this process can provide creative insight into the relationships that develop between modern-day physicians and the patients incorporates distance and disappointment as well as recognition and rehabilitation, unresolved fear as well as pragmatic hope. In treating Victor "as if" he were the medical doctor he is training to become and the Creature his perceived difficult patient, we do not place Shelley's novel in a cultural history of medicine that it might be seen to allegorize. Speaking with Victor's failure helps us imagine physicians who, instead of mirroring societal fears of decay and death, find the courage to stand with the patients they have helped to birth into a new life story. At the very least, we sense in Victor's evasion of responsibility new openings to speak about the ethical relationship between physicians and patients. cache = ./cache/cord-012469-6cvu5umd.txt txt = ./txt/cord-012469-6cvu5umd.txt === reduce.pl bib === id = cord-012902-efprpk72 author = nan title = Abstracts from the 2020 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS) date = 2020-09-15 pages = extension = .txt mime = text/plain words = 10209 sentences = 701 flesch = 55 summary = Methods: An iontophoretic pilocarpine-induced sweat sample, measures of TEWL (Tewameter ® , COURAGE +KHAZAKA electronic GmbH, Köln, Germany) and a skin punch biopsy were collected from adult, non-pregnant hypertensive patients at the Glasgow Blood Pressure Clinic (n = 90; age: 56 ± 16, range 21-86 years; females = 48.9%; BMI: median = 29.8, interquartile range 26.9-35.2 kg/m²). Results: Subjects with high NM (n = 30, 15 men) had greater body mass index than those with low NM (n = 30, 17 men): (mean ± SD) 31 ± 7 vs 27 ± 4 kg/m 2 (p < 0.05), but the two groups were similar with respect to age and brachial blood pressure (BP). This study investigates the feasibility of CPET for safe and effective cardiovascular exercise prescription in hypertensive patients Methods: 14 subjects (10 Male, 4 Female; aged 61.8 ± 10.8 years) with hypertension and undergoing medical therapy were recruited to the study. This study aims to investigate the patient factors associated with the prescribing of blood pressure lowering medications after any index stroke in Scotland. cache = ./cache/cord-012902-efprpk72.txt txt = ./txt/cord-012902-efprpk72.txt === reduce.pl bib === id = cord-013003-gxd29jxf author = Vora, Darshan title = Surgical management of a complex case of Charcot arthropathy of the spine: a case report date = 2019-08-22 pages = extension = .txt mime = text/plain words = 2262 sentences = 123 flesch = 42 summary = INTRODUCTION: The authors present a case of a 55-year-old male with T10 complete paraplegia diagnosed with Charcot arthropathy of the spine (CAS). CAS is now a well-defined long-term complication following traumatic spinal cord injury (SCI), developing on average 17 years after injury. Here we describe the case of a patient with paraplegia who developed CAS following a traumatic SCI complicated by a complex hospital course. Autonomic dysreflexia associated with Charcot spine following spinal cord injury: a case report and literature review Charcot joint of the spine, a cause of autonomic dysreflexia in spinal cord injured patients Management of autonomic dysreflexia associated with Charcot spinal arthropathy in a patient with complete spinal cord injury: Case report and review of the literature Four-rod instrumentation for treatment of Charcot spinal arthropathy causing autonomic dysreflexia: case report and literature review cache = ./cache/cord-013003-gxd29jxf.txt txt = ./txt/cord-013003-gxd29jxf.txt === reduce.pl bib === id = cord-011836-zib8wkm2 author = Urman, Jesús M. title = Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach date = 2020-06-21 pages = extension = .txt mime = text/plain words = 13598 sentences = 626 flesch = 44 summary = We performed metabolomic and proteomic analyses of bile from patients with benign (n = 36) and malignant conditions, CCA (n = 36) or PDAC (n = 57), undergoing endoscopic retrograde cholangiopancreatography with the aim of characterizing bile composition in biliopancreatic disease and identifying biomarkers for the differential diagnosis of biliary strictures. Alterations in BA In the present study we have performed parallel metabolomic and proteomic analyses of human bile from patients with benign and malignant (CCA and PDAC) biliary stenoses. Therefore, using a novel approach, we have combined metabolomic and proteomic measurements with machine intelligence modeling and synthetic data generation [51, 53, 54] to identify molecular patterns that can discriminate malignant from benign biliary strictures. An equivalent analysis was performed with the proteomic data obtained from a different set of bile samples from control and patients with PDAC-related malignant stenoses. An equivalent analysis was performed with the proteomic data obtained from a different set of bile samples from control and patients with PDAC-related malignant stenoses. cache = ./cache/cord-011836-zib8wkm2.txt txt = ./txt/cord-011836-zib8wkm2.txt === reduce.pl bib === id = cord-013116-n7auvqh3 author = Srinivas, A. title = Testing the limits of UDCs date = 2020-10-09 pages = extension = .txt mime = text/plain words = 794 sentences = 56 flesch = 58 summary = authors: Srinivas, A.; Moshkun, C.; Darcey, J. History revealed that the 17 had been removed four months prior to presentation due to similarly vague symptoms. He had already begun a course of antibiotics and was using chlorhexidine mouth rinses prescribed remotely via an urgent dental centre (UDC). The pain had reduced but there was still discomfort in the area and the patient reported it to feel sharp on his tongue. The patient contacted UDHM six weeks later with ongoing pain and a face-to-face review was arranged. In that time he had not been offered a face-to-face review but rather been given a further two courses of antibiotics after remote UDC consultations. Reflecting back over this patient's history and clinical encounters there were signs that may have pointed towards a nonodontogenic diagnosis. Darcey, Manchester, UK https://doi.org/10.1038/s41415-020-2226-y missing a serious diagnosis or misdiagnosing. cache = ./cache/cord-013116-n7auvqh3.txt txt = ./txt/cord-013116-n7auvqh3.txt === reduce.pl bib === id = cord-013139-b32xg7y7 author = Colak, Fatma Kurt title = An intronic variant in BRAT1 creates a cryptic splice site, causing epileptic encephalopathy without prominent rigidity date = 2020-10-10 pages = extension = .txt mime = text/plain words = 2783 sentences = 147 flesch = 44 summary = Since the discovery of BRAT1 variants as the molecular etiology of lethal neonatal rigidity and multifocal seizure syndrome (RMFSL, OMIM 614498), these variants have also been identified in patients with milder clinical forms including neurodevelopmental disorder with cerebellar atrophy and with or without seizures (NEDCAS, OMIM 618056), epilepsy of infancy with migrating focal seizures (EIMFS), and congenital ataxia (CA). This study aims to examine the consequences and pathogenicity of a novel homozygous splice site variant in BRAT1 in a patient presenting with migrating focal seizures since birth without prominent rigidity. RMFSL was first described in 2012; later, BRAT1 variants were also reported in patients with non-lethal milder clinical forms, including neurodevelopmental disorder with cerebellar atrophy and with or without seizures (NEDCAS, 618056), epilepsy of infancy with migrating focal seizures (EIMFS), and congenital ataxia (CA) [7] [8] [9] [10] . cache = ./cache/cord-013139-b32xg7y7.txt txt = ./txt/cord-013139-b32xg7y7.txt === reduce.pl bib === id = cord-013105-tmhce7p5 author = Kalil, Andre C. title = Less is more: critically ill status is not a carte blanche for unlimited antibiotic use date = 2020-10-09 pages = extension = .txt mime = text/plain words = 1496 sentences = 66 flesch = 28 summary = In addition, we propose that health-care providers can bring concrete and direct benefits to each of our critically ill patients at the bedside by preventing the excessive use of unnecessary antibiotics. The clinical deterioration of mechanically ventilated patients may be associated with a new infection process; however, the majority of ventilator-associated events leading to antibiotic administration is related to noninfectious processes [6] ; thus, the appropriate antimicrobial de-escalation is essential and can be safely done if culture results are negative [7, 8] . For many decades, critically ill patients have been treated with antibiotics during two to three weeks for severe infections including pneumonias, abdominal and urinary infections, all of which still comprise the majority of infections leading to sepsis and admission to the intensive care unit. Effect of aminoglycoside and beta-lactam combination therapy versus beta-lactam monotherapy on the emergence of antimicrobial resistance: a meta-analysis of randomized, controlled trials cache = ./cache/cord-013105-tmhce7p5.txt txt = ./txt/cord-013105-tmhce7p5.txt === reduce.pl bib === id = cord-013370-gktnz644 author = Abreu, Maria T title = Providing Guidance During a Global Viral Pandemic for the Care of Patients With Inflammatory Bowel Disease date = 2020-10-21 pages = extension = .txt mime = text/plain words = 1840 sentences = 83 flesch = 56 summary = We have partnered closely with the European Crohn's and Colitis Organisation because of our shared desire to provide the best guidance to patients with inflammatory bowel disease at a global level, as well as to the physicians that are caring for these patients. The process is called a RAND panel wherein the members of IOIBD, as well as other very knowledgeable practitioners of IBD, voted on a series of statements largely having to do with the risk of infection with the SARS-CoV-2 virus and the development of COVID-19 in patients who have IBD. We urge you to continue to check the IOIBD or the ECCO websites for the most up-to-date information, and we hope to keep updating the guidance in all of the various dimensions of IBD care. cache = ./cache/cord-013370-gktnz644.txt txt = ./txt/cord-013370-gktnz644.txt === reduce.pl bib === id = cord-012934-c6pbr64i author = Hao, Weiming title = Vestibular prognosis in idiopathic sudden sensorineural hearing loss with vestibular dysfunction treated with oral or intratympanic glucocorticoids: a protocol for randomized controlled trial date = 2020-07-22 pages = extension = .txt mime = text/plain words = 5443 sentences = 280 flesch = 43 summary = title: Vestibular prognosis in idiopathic sudden sensorineural hearing loss with vestibular dysfunction treated with oral or intratympanic glucocorticoids: a protocol for randomized controlled trial The primary outcomes will be vestibular function outcomes assessed by sensory organization test, caloric test, video head impulse test, cervical vestibular evoked myogenic potential, and ocular vestibular evoked myogenic potential; the secondary outcomes include self-reported vestibular dysfunction symptoms; dizziness-related handicap, visual analogue scale for vertigo and tinnitus; and pure tone audiometry. To evaluate the recovery of vestibular function, we set the recovery rates of the whole battery of vestibular function tests (SOT/caloric test/vHIT/VEMPs) as the primary outcome, which is the proportion of patients whose abnormal results of vestibular function tests at baseline recover to normal at 4-/8-week follow-up: in this study, we define a 10-dB PTA criterion as clinically significant difference based on a previous RCT [9] . cache = ./cache/cord-012934-c6pbr64i.txt txt = ./txt/cord-012934-c6pbr64i.txt === reduce.pl bib === id = cord-013148-qbxbndsl author = Manzano-Nunez, Ramiro title = Outcomes and management approaches of resuscitative endovascular balloon occlusion of the aorta based on the income of countries date = 2020-10-12 pages = extension = .txt mime = text/plain words = 3931 sentences = 192 flesch = 45 summary = Propensity score matching extracted 1:1 matched pairs of subjects who were from an LMIC or a HIC based on age, gender, the presence of pupillary response on admission, impeding hypotension (SBP ≤ 80), trauma mechanism, ISS, the necessity of CPR on arrival, the location of REBOA insertion (emergency room or operating room) and the amount of PRBCs transfused in the first 24 h. CONCLUSION: There is considerable variation in the management practices of REBOA and the outcomes associated with this intervention between HICs and LMICs. Although we found significant differences in multiorgan and respiratory failure rates, there were no differences in the risk-adjusted odds of mortality between the groups analyzed. In order to address the variations between regions and countries in relation to their income, we aim to compare the management approaches and clinical outcomes of trauma patients resuscitated with REBOA according to the countries' income based on the World Bank Country and Lending Groups. cache = ./cache/cord-013148-qbxbndsl.txt txt = ./txt/cord-013148-qbxbndsl.txt === reduce.pl bib === id = cord-012518-ncrdwtdg author = nan title = Abstractband DOG 2020 date = 2020-08-24 pages = extension = .txt mime = text/plain words = 32627 sentences = 2475 flesch = 59 summary = The improvement in tear film quality (measured by TBUT) was shown after application of trehalose/hyaluronate tear substitute for one month in both, glaucoma and control group patients with mild to moderate dry eye symptoms. Methods: For 351 eyes (275 patients) who underwent DMEK for Fuchs endothelial corneal dystrophy (FECD), donor ECD decrease as compared to preoperative donor ECD was evaluated up to four years after surgery. The present study included fundus images of 111 individuals with a mean refractive error of -9.3 ± 3.8 diopters (range:-20.8, +1.75) and an axial length of 26.8 ± 1.9 mm (range: 22.55, 30.88) Results: The disc-fovea distance increased significantly with longer axial length, with a relatively flat slope in the non-highly myopic eyes (Disc-Fovea-Distance = 24.3 × Axial Length (mm)+514) and a steeper slope in the highly myopic group (Disc-Fovea-Distance = 58.7 × Axial Length (mm)-460). cache = ./cache/cord-012518-ncrdwtdg.txt txt = ./txt/cord-012518-ncrdwtdg.txt === reduce.pl bib === id = cord-012560-p5s0p7fd author = Decavèle, Maxens title = One-year survival of patients with high-grade glioma discharged alive from the intensive care unit date = 2020-08-29 pages = extension = .txt mime = text/plain words = 3703 sentences = 178 flesch = 43 summary = We sought to quantify 1-year mortality and evaluate the association between mortality and (1) functional status, and (2) management of anticancer therapy in patients with high-grade glioma discharged alive from the intensive care unit. On multivariate logistic regression analysis, two factors were independently associated with lower mortality 1 year after ICU admission: continuation of anticancer therapy after ICU discharge (OR 0.18, 95% CI 0.03-0.75, p = 0.028), and Karnofsky performance status at ICU admission (OR 0.90, 95% CI 0.85-0.95, p < 0.001). The main results of the study can be summarized as follows: in HGG patients discharged alive after an unplanned medical ICU stay (1), we observed a substantial proportion of survivors 1 year after ICU admission (more than one quarter of patients) and most of these patients exhibited relatively favorable performance status even 1 year after ICU admission, (2) continuation of anticancer therapy was possible in almost 50% of patients and was strongly associated with cancer progression and use of corticosteroids at admission, and (3) continuation of anticancer therapy and Karnofsky performance status at admission were associated with higher 1-year survival rates. cache = ./cache/cord-012560-p5s0p7fd.txt txt = ./txt/cord-012560-p5s0p7fd.txt === reduce.pl bib === id = cord-013589-3l8kar3k author = Doummar, Diane title = Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia date = 2020-05-28 pages = extension = .txt mime = text/plain words = 4136 sentences = 249 flesch = 47 summary = A homozygous missense variant leading to drastic decrease of PDE2A enzymatic activity was reported in one patient with childhood-onset choreodystonia preceded by paroxysmal dyskinesia and associated with cognitive impairment and interictal EEG abnormalities. The phenotype of the two oldest patients, aged 9 and 26, was characterized by childhood-onset refractory paroxysmal dyskinesia initially misdiagnosed as epilepsy due to interictal EEG abnormalities. Together with previously reported case, our three patients confirm that biallelic PDE2A variants are a cause of childhood-onset refractory paroxysmal dyskinesia with cognitive impairment, sometimes associated with choreodystonia and interictal baseline EEG abnormalities or epilepsy. reported a missense homozygous variant in PDE2A in a patient with cognitive impairment, interictal EEG abnormalities, and childhoodonset chorea [8] . indicate that biallelic variants in PDE2A leading to loss of function are involved in heterogeneous phenotypes characterized by early-onset paroxysmal hyperkinetic movement disorders associated with cognitive impairment and possibly epilepsy. cache = ./cache/cord-013589-3l8kar3k.txt txt = ./txt/cord-013589-3l8kar3k.txt === reduce.pl bib === id = cord-014833-ax09x6gk author = Wu, Jia title = Data Decision and Transmission Based on Mobile Data Health Records on Sensor Devices in Wireless Networks date = 2016-06-20 pages = extension = .txt mime = text/plain words = 4029 sentences = 293 flesch = 61 summary = title: Data Decision and Transmission Based on Mobile Data Health Records on Sensor Devices in Wireless Networks History data, collection data, and doctor-analyzed data could be computed and transmitted to patients using sensor devices. This study establishes a new method that can decide and transmit effective data based on sensor device mobile health in wireless networks. This study establishes a new method that can decide and transmit effective data based on sensor device mobile health in wireless networks. According to an established mobile health system, patients can obtain timely treatment from doctors or hospitals by using wireless sensor devices. In mobile health, sensor devices and mobile device are the cheapest and most convenient means of data collection and transmission among doctors, patients, and hospitals. Formula (8) assumes that a ¼ 0:15; b ¼ 0:35; c ¼ 0:5: Sensor devices may calculate the probability and transmit diagnosis data to the mobile APP to be evaluated by patients and doctors. cache = ./cache/cord-014833-ax09x6gk.txt txt = ./txt/cord-014833-ax09x6gk.txt === reduce.pl bib === id = cord-007890-bie1veti author = nan title = ECC-4 Abstracts date = 2002-04-16 pages = extension = .txt mime = text/plain words = 85992 sentences = 5665 flesch = 50 summary = Effects of Interferon alpha plus ribavirine therapy on frequencies of HCV, HIV and CMV specific CD4-T-cell responses in peripheral blood of HIV/HCV coinfected patients after 6 months of treatment SoA9.5 Methods: Two groups of patients with chronic HCV infection were studied: 26 HIV coinfected progressors with antiretroviral therapy and 13 HIV-negative controls. In order to assess the local temporal trend of antibiotic sensitivity of the most common urinary tract bacterial pathogen, all urine-cultured Escherichia coli isolates were reviewed as to susceptibility profile, and specimen source (community-versus hospital-acquired infection). Methods: A total of 87 penicillin resistant clinical strains isolated from patients at Hacettepe Children's Hospital, Ankara, Turkey between 1999 and 2001 were tested for their in vitro susceptibility to various antibiotics that are commonly used in the treatment of respiratory tract infections. cache = ./cache/cord-007890-bie1veti.txt txt = ./txt/cord-007890-bie1veti.txt === reduce.pl bib === id = cord-014540-27hnlu5v author = Sutthiruk, Nantanit title = Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC): Bangkok, Thailand. 12-15 February 2017 date = 2017-02-22 pages = extension = .txt mime = text/plain words = 24509 sentences = 1304 flesch = 46 summary = A secondary questionnaire was sent to determine whether any cases showed a positive blood or cerebral spinal fluid culture for Extended Spectrum Beta-lactamase (ESBL) producing GNB, AmpC β-lactamases producing GNB, or carbapenem-resistant enterobacteriacae (CRE) between April 2012 and March 2015.The following data were collected; demographic data pertaining to both the care facilities and patients, clinical diagnosis, and outcomes. Utilization of diagnosis-procedure combination data for advancing the antimicrobial stewardship program Haruo Nakayama, Toshiko Ota, Naoko Shirane, Chikako Matuoka, Kentaro Kodama, Masanobu Ohtsuka Toho University Ohashi medical center, Tokyo, Japan Background Infection with antibiotic-resistant bacteria results in increased morbidity, mortality and economic burden. The purpose of this study was to test the effectively of the Infection Control Risk Assessment (ICRA) monitoring tool developed by the Infection Prevention and Control Unit (IPCU) of Asian Hospital and Medical Center with the aim to increase the compliance of construction workers to recommended infection prevention and control measures during construction, renovation and demolition in the hospital. cache = ./cache/cord-014540-27hnlu5v.txt txt = ./txt/cord-014540-27hnlu5v.txt === reduce.pl bib === id = cord-013457-rqon1adg author = De Cannière, Hélène title = Short-Term Exercise Progression of Cardiovascular Patients throughout Cardiac Rehabilitation: An Observational Study date = 2020-09-29 pages = extension = .txt mime = text/plain words = 7360 sentences = 399 flesch = 45 summary = The goal of the study was to obtain a better understanding of the short-term progression of functional capacity throughout multidisciplinary CR, measured as the change in walking distance between baseline six-minute walking test (6MWT) and four consecutive follow-up tests. Although the majority of studies on home-and center-based CR programs report data on changes in exercise capacity measured at baseline and on completion of the intervention limited information is available on the short-term progression in exercise capacity throughout the CR [20] [21] [22] . A one-way repeated measures ANOVA was conducted to determine whether there were statistically significant differences in mean 6MWT distance (6MWD) over the period of a three-month rehabilitation program. Future studies should investigate whether similar progression patterns emerge in both center-based (including with larger patient groups) and in home-based CR programs and whether this short-term information on progression can be used to optimize outcomes by improving exercise capacity and motivation. cache = ./cache/cord-013457-rqon1adg.txt txt = ./txt/cord-013457-rqon1adg.txt === reduce.pl bib === === reduce.pl bib === id = cord-014538-6a2pviol author = Kamilia, Chtara title = Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date = 2017-01-10 pages = extension = .txt mime = text/plain words = 61068 sentences = 3463 flesch = 49 summary = Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). cache = ./cache/cord-014538-6a2pviol.txt txt = ./txt/cord-014538-6a2pviol.txt === reduce.pl bib === id = cord-013380-1jwzbgwb author = Parrilla, Claudio title = A one-year time frame for voice prosthesis management. What should the physician expect? Is it an overrated job? date = 2020-08-17 pages = extension = .txt mime = text/plain words = 3406 sentences = 205 flesch = 47 summary = The management of these issues is considered time demanding, often causes anxiety in non-experienced non-specifically trained specialists and, in the real world, it represents the main obstacle for many physicians to voice prosthesis rehabilitation. The aim of this paper is to analyse a 1-year window of troubleshooting in a multidisciplinary setting for a large cohort of voice prosthesis rehabilitated patients, to quantify how demanding management is and to propose an algorithm that is useful to minimise the time and burden for dedicated clinicians. To address the first issue, we analysed a 1-year time frame of management in a large cohort of voice prosthesis rehabilitated patients and, as a result, we developed a trouble-shooting algorithm with a technical flow chart to achieve quick and correct identification and adequate treatment of complications (Fig. 1) . Our study highlights the importance of a systematic approach in the management of late complications in voice prosthesis rehabilitated patients. cache = ./cache/cord-013380-1jwzbgwb.txt txt = ./txt/cord-013380-1jwzbgwb.txt === reduce.pl bib === id = cord-015090-n6f4xupw author = nan title = PS 339-563 date = 2005-09-10 pages = extension = .txt mime = text/plain words = 26280 sentences = 1560 flesch = 53 summary = We designed this study to examine the effects of fiberoptic bronchoscopy (FOB) with and without BAL on body temperature, systemic arterial pressure, heart rate and supportive therapies requirements in mechanically ventilated patients. Clinical characteristics (Glasgow scale, heart rate, systolic blood pressure), cardiac enzymes (troponin I, total serum creatine kinase and myocardial isoenzyme, myoglobin), ECG changes (ST-T changes, prolonged QT and corrected QT intervals), echocardiographic assessment of cardiac function (left ventricular ejection fraction, hypokinesia) were studied on the day of the admission. It is a prospective study performed during 12 months of the patients with brain trauma admitted in a 24-beds medical-surgical ICU of a 650-beds university hospital. This prospective observational study included 200 adult patients admitted to a 31-bed university hospital medical-surgical ICU during a 3-month period. cache = ./cache/cord-015090-n6f4xupw.txt txt = ./txt/cord-015090-n6f4xupw.txt === reduce.pl bib === id = cord-013558-0sa63lp3 author = Farwana, Reem title = Watch this space: a systematic review of the use of video-based media as a patient education tool in ophthalmology date = 2020-03-09 pages = extension = .txt mime = text/plain words = 2531 sentences = 139 flesch = 46 summary = Eligible articles included peer-reviewed studies involving ophthalmology patients, who received a solely video-based educational intervention to assess for improvement in patient knowledge, behaviour and overall health-related outcomes. This systematic review of the existing literature aimed to assess the efficacy of using video-based media for patient education in ophthalmology. Studies were included in this systematic review if they involved the use of video-based media as a sole intervention for patient education in ophthalmology with endpoints focussed on its impact on patient knowledge, health behaviour or overall clinical outcome. We aimed to study the extent of use of video-based media in influencing patient knowledge, health behaviour and overall clinical outcome. Due to the low number of the studies and heterogeneity of the interventions used and outcomes reported, it is challenging to reach any firm conclusions on the validity of the use of video-based media as a patient education tool in ophthalmology. cache = ./cache/cord-013558-0sa63lp3.txt txt = ./txt/cord-013558-0sa63lp3.txt === reduce.pl bib === id = cord-014670-e31g8lns author = nan title = Poster Sessions 313-503 date = 2004-10-05 pages = extension = .txt mime = text/plain words = 28575 sentences = 1706 flesch = 55 summary = Over a 12-month period patients who needed reintubation after successful trial of weaning and planned extubation, in a polyvalent intensive care unit (ICU) were identified.Data including clinical features (age, sex, SAPS II on admission, Glasgow Coma Score (GCS) on day of extubation, type of patient, length of intubation and mechanical ventilation (MV) before extubation, length of ICU stay (LOS), ICU and hospital mortality) were collected.Moreover we considered two parameters that asses airway patency and protection like predictors of EF:cough strength and suctioning frequency after extubation.Cough strength on command was measured with a semiobjective scale of 0 to 5 (0= weak cough, 5= strong cough). (3/23)(13.2%), pulmonary embolism(1/23)(4.3%)and severe sepsis(1/23)(4.3%).Seven of patients who received reintubation a cause of defective airway manage needed at least one suctioning every two hours; moreover the same patients and other three with alteration in neurological function had weak cough (grade 0 to 2).The LOS of EF patients was 23±24.3 days, their ICU and hospital mortality were 39.1% and 47.8%, respectively, both higher when compared with not reintubated patients.Results of logistic regression showed that SAPS II is the only independent risk-factor of reintubation (odds ratio 1.056, sig. cache = ./cache/cord-014670-e31g8lns.txt txt = ./txt/cord-014670-e31g8lns.txt === reduce.pl bib === id = cord-014933-3jezc081 author = Özdemir, Seray Karagöz title = Investigation of seasonal frequency and pathogens in febrile neutropenia date = 2019-01-15 pages = extension = .txt mime = text/plain words = 1807 sentences = 110 flesch = 51 summary = authors: Özdemir, Seray Karagöz; Iltar, Utku; Salim, Ozan; Yücel, Orhan Kemal; Erdem, Ramazan; Turhan, Özge; Undar, Levent The first aim of study was to determine the difference in frequency of febrile neutropenic episodes (FNEs) according to months and seasons. Febrile neutropenia (FEN) is the most common complication requiring hospitalization and causing mortality in patients with hematological cancer. The primary aim of the study was to investigate whether there is a relationship between the frequency of febrile neutropenic episodes (FNEs) and seasons in hematological cancer patients. In addition, neutrophil count, C-reactive protein (CRP) level, length of hospitalization, culture results of blood and other body specimens, isolated pathogens, detected foci of infection, and antibacterial, antiviral, or antifungal treatments were reviewed. The second aim of the study was to determine the type and frequency of pathogens detected in FNEs in patients with hematologic cancer. cache = ./cache/cord-014933-3jezc081.txt txt = ./txt/cord-014933-3jezc081.txt === reduce.pl bib === id = cord-015082-l629n8is author = nan title = Poster Sessions 323-461 date = 2002-08-29 pages = extension = .txt mime = text/plain words = 26569 sentences = 1648 flesch = 52 summary = 14 patients awaiting urgent cardiac surgical re-vascularisation were studied with measurement of: spirometry; percentage increase in transfer factor from sitting to lying position (TF) as an indicator of micro-vascular lung disease; overnight oximetry on air; and 24hour holter monitoring Patients, who were reintubated on decreased indices of arterial oxygenation under MOSF progressing died in 100% cases ( NIMV is effective method in complex therapy of ARF, developing in postoperative period after cardiac surgery, that leads to significant improvement of lungs biomechanics and gases change function. In a prospective observational study we performed bedside ptO2 measurements in 8 patients with sepsis/septic shock to gain insight in ptO2 values and their dynamic changes related to the course of the illness, as well as investigating the practical applicability of tissue oxygen measurement in the ICU setting. cache = ./cache/cord-015082-l629n8is.txt txt = ./txt/cord-015082-l629n8is.txt === reduce.pl bib === id = cord-015335-l0kjxhd1 author = nan title = Irish Society of Gastroenterology: Proceedings for summer meeting – 26th/27th May 1995 in Galway date = 1995 pages = extension = .txt mime = text/plain words = 8724 sentences = 508 flesch = 52 summary = The results suggest that an aneuploid DNA pattern is a predictor of high risk potential for metastases to the liver and may be a useful tool in the "followup" of patients with gastric carcinoma in detecting those at high risk of developing metastases following surgical resection. A partially purified preparation of oesophageal tumour-derived inimune suppressor factor that has been shown to be free of all known cytokines was tested in dose-ranging studies on cell proliferation and apoptosis using lymphocytes from the mutant and control mice. Currie et al have demonstrated that arginase is cytotoxic to tumour cells by depletion of the essential amino acid L-arginine, therefore the aim of this study was to determine the role of this enzyme in colorectal tumour-derived MOs. Human peripheral blood monocytes (PBM) were isolated from aged-matched controls (CON) and from blood pre-operatively obtained from patients undergoing surgery for colorectal cancer. cache = ./cache/cord-015335-l0kjxhd1.txt txt = ./txt/cord-015335-l0kjxhd1.txt === reduce.pl bib === id = cord-014965-efmozngq author = nan title = Infectious diseases other than CMV (1st Section) date = 2001-06-11 pages = extension = .txt mime = text/plain words = 8007 sentences = 453 flesch = 51 summary = To evaluate the influence of the helicobacter pylori (h.p.) infection on gastrointestinal complications after high-dose chemotherapy and stem cell transplantation (STX) we tested 114 patients (54 female, 60 male) by the 13C-urea breath test prior to initiation of conditioning therapy. 26 immunocompromised patients (15-70 y, median 44; 17 leukemia, 7 myeloma, 2 lymphoma) received 32 courses of ABLC at the median daily dose of 2 mg/kg rounded off to the nearest vial size (range, 1.3-2.7 mg/kg) after autologous (n=7) or allogeneic (n=8) stem cell transplantation or chemotherapy (n=17). Seven of the 12 allogeneic transplanted patients with at least one positive PCR-result had a VZV-disease. All (n=2) of the autologous transplanted patients with a positive PCR-result developed a VZV-disease. Background: Severe acute graft-versus-host-disease (aGvHD) of the gut is still a major complication after allogeneic stem-cell transplantation (SCT) as response rates to treatment (tx) of intestinal GvHD (iGvHD) are lower than those observed for GvHD of the skin. cache = ./cache/cord-014965-efmozngq.txt txt = ./txt/cord-014965-efmozngq.txt === reduce.pl bib === id = cord-015162-6be21d59 author = nan title = Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin date = 2016-05-04 pages = extension = .txt mime = text/plain words = 6831 sentences = 725 flesch = 54 summary = Aim of the study: To investigate whether the use of Ticagrelor in comparison to other platelet-inhibitors is associated with a greater risk of bleeding or death in patients with acute myocardial infarction in the emergency room. Initiale Laborwerte: pH 7,2, pO 2 9,3 kPa (unter 3 l O 2 /min), pCO 2 5,8 kPa, BE -10, HCO 3 17; K+ 3,4; Na 143; Hb 6,8; Kreatinin 106; Harnstoff 3,5; Lactat 7,3; Glucose 9 (je mmol/l); Leukozyten: 12 (je Gpt/l); Methode: Therapie in den ersten 12 Stunden: Übernahme auf die Intensivstation, dort Intubation, rasch sich entwickelnder exzessiver Katecholaminbedarf mit Kreislaufstillstand und Reanimation. This difference does not lead to higher in-hospital mortality as compared to men in Hintergrund: Akute Herzinsuffizienzsyndrome (AHFS) sind die häufigste Ursache für Hospitalisierungen in Deutschland, verursachen enorme Kosten und zeigen eine hohe Mortalität. Ziel der Studie ist es den fungalen Biomarker 1,3-Beta-D-Glucan (BDG) hinsichtlich einer frühen Detektion einer IM und als Outcome-Parameter bei immunsupprimierten Intensivpatienten mit septischen Schock zu evaluieren. cache = ./cache/cord-015162-6be21d59.txt txt = ./txt/cord-015162-6be21d59.txt === reduce.pl bib === id = cord-015389-vwgai4k9 author = nan title = Publication only date = 2009-03-25 pages = extension = .txt mime = text/plain words = 23868 sentences = 1465 flesch = 57 summary = This study evaluates the safety of this approach, in terms of infusion-related toxicity and hematopoietic reconstitution, in 385 consecutive autologous transplantations performed from 4/97 to 9/08 in 348 patients (median age 46; underlying disease: lymphoma in 178, myeloma in 131, acute leukaemia in 17, breast cancer in 22). Patients and methods: Eight pts after allogeneic hematopoetic stem cell transplantation (HSCT) underwent MSCs infusions (median age of pts was 11 years, male/female: 6/2) between 2006 and 2009. Akiyama Tokyo Metropolitan Komagome Hospital (Tokyo, JP) Acute graft-versus-host disease (GVHD) is one of the major factors that have infl uence on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Material and methods: during a 8 years period we have performed 144 stem cells transplantation in 134 patients with different hematological malignancies(AML: 74; ALL: 6; CML: 7; CLL: 1, NHL: 13; Hodgkin Diseases: 16; Multiple myelomas: 24; Aplastic anaemia: 1;Myelofi brosis:1 Ewing Sarcoma: 1; Male:78 Female 66. cache = ./cache/cord-015389-vwgai4k9.txt txt = ./txt/cord-015389-vwgai4k9.txt === reduce.pl bib === id = cord-010980-sizuef1v author = nan title = ECTES Abstracts 2020 date = 2020-05-11 pages = extension = .txt mime = text/plain words = 132644 sentences = 8727 flesch = 53 summary = We hypothesized that presentation to a PTC would yield increased mortality when subspecialty intervention was required and that this would be most pronounced at night when in-house attending coverage is absent at all state PTCs. Materials and methods: A review of the Pennsylvania Trauma Outcome Study (PTOS) database was performed to capture patients aged 12-18 who underwent any non-orthopedic trauma surgery. Traumatic subaxial cervical fractures: functional prognostic factors and survival analysis Introduction: The main goal of this study is to identify the risk factors for poor functional outcomes and to analyze the overall survival (OS) and complications rate in patients with traumatic cervical spinal cord injury (SCI) and subaxial cervical fracture (SACF) treated with open surgical fixation. After applying a multiple imputation on all the study variables, a logistic regression generalized estimating equation after adjustment for age, sex, mechanism of trauma, and the injury severity score as covariates and hospitals as a cluster assessed an association between quartile of patient volume in intensive care unit and hospital mortality. cache = ./cache/cord-010980-sizuef1v.txt txt = ./txt/cord-010980-sizuef1v.txt === reduce.pl bib === id = cord-014980-cz1gx9oj author = Cheng, Qinglin title = Nomogram for the Individualized Prediction of Survival Among Patients with H7N9 Infection date = 2020-03-20 pages = extension = .txt mime = text/plain words = 6145 sentences = 315 flesch = 46 summary = Stepwise selection was applied to the data, which resulted in a final model with 8 independent predictors [including initial PaO(2)/FiO(2) ratio ≤300 mmHg, age ≥60 years, chronic diseases, poor hand hygiene, time from illness onset to the first medical visit, incubation period ≤5 days, peak C-reactive protein ≥120 mg/L], and initial bilateral lung infection. 11 To better evaluate the predictors associated with survival outcomes, based on a matched case−control study (1:2 ratios), we retrospectively investigated the sociodemographic, clinical and epidemiological data of 227 laboratoryconfirmed cases of H7N9 VI in Zhejiang province, China, between March 1, 2013, and May 31, 2019. With 8 variables of training set such as IPFR ≤300 mmHg, IBLI, peak CRP ≥ 120 mg/L, TIOFMV, IP ≤ 5 days, CD, PHH, and age ≥60 years in Table 4 , it was possible to create a nomogram to predict the probability of survival from influenza A (H7N9) (Figure 2 ). cache = ./cache/cord-014980-cz1gx9oj.txt txt = ./txt/cord-014980-cz1gx9oj.txt === reduce.pl bib === id = cord-015930-18qznqp0 author = Denstaedt, Scott J. title = Hemophagocytic Lymphohistiocytosis and Other Culture Negative Sepsis-Like Syndromes in the ICU date = 2019-07-24 pages = extension = .txt mime = text/plain words = 4494 sentences = 235 flesch = 35 summary = Given his unremarkable bone marrow biopsy 7 days before and elevated fibrinogen, the possibility of hemophagocytic lymphohistiocytosis (HLH) was dismissed as his hyperferritinemia and elevated sIL-2R were attributed to history of blood transfusion and occult infection. A recent consensus review on malignancy-associated HLH suggests tailoring treatment to the underlying trigger, performance status, organ function and additional therapies the patient is receiving [12] . In critically ill adults, however, the increased prevalence of conditions which elevate ferritin, such as infection, malignancy, autoimmune disease, liver injury and chronic blood transfusion make hyperferritinemia a nonspecific finding for HLH [26, 27] . While effective in inducing bone marrow remission [43] [44] [45] , CAR-T cells may be associated with the development of cytokine release syndrome (CRS) which frequently requires treatment in the ICU. Several important clinical syndromes, including HLH, MAS, IPS, and CRS can mimic sepsis and cause critical illness through immune dysregulation in the absence of infection. cache = ./cache/cord-015930-18qznqp0.txt txt = ./txt/cord-015930-18qznqp0.txt === reduce.pl bib === id = cord-014533-6qfecv5h author = Velasquez, T. title = ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date = 2016-09-29 pages = extension = .txt mime = text/plain words = 88380 sentences = 5139 flesch = 52 summary = P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. Methods: This descriptive observational study was conducted on consecutive 100 pediatric surgical patients who admitted to PSICUs at Cairo University Hospitals starting from 1/6-1/12/2015.After approval by research ethics committee,informed consents were obtained from parents and pediatric cases aged from 1 month-18 years and stayed for > 48 h were enrolled.MPV and PLC were obtained and recorded at baseline(preoperative values),on the day of ICU admission(day 0),1 st ,2 nd ,3 rd ,5 th and 7 th days.To measure daily MPV changes; (ΔMPV) was constructed and computed where ΔMPV = ([MPVday(X) − MPVday (0)]/MPVday(0) × 100 %. Results: The results obtained after analyzing the two homogeneous groups according to age, gender, type of admission and severity influencing the physiotherapy care in ICU quality indicators, in the Sagrada Esperança clinic, highlights the decrease of the average number of days with mechanical ventilation but it is not observed a significant relation between physical therapy and this indicator (p = 0:06). cache = ./cache/cord-014533-6qfecv5h.txt txt = ./txt/cord-014533-6qfecv5h.txt === reduce.pl bib === id = cord-014987-nycbjqn6 author = nan title = OP 0364-0412 date = 2006-08-24 pages = extension = .txt mime = text/plain words = 9795 sentences = 580 flesch = 55 summary = In the "Prevalence of severe sepsis and septic shock in Intensive Care Units in Germany" study, a prospective observational cross-sectional study, data from 454 ICUs in 310 randomly selected hospitals in Germany were collected by local one-day visits of trained physicians from SepNet's 17 regional study centers. Despite the higher APACHE II score in both groups (median score 21 or 18.5, respectively compared with 16.5 in the enteral group, p<0.01) our results indicate that parenteral nutrition has an important attributable effect on mortality in septic patients. In this follow up study, we document the impact of intensive insulin therapy on long term mortality and objective and subjective well-being of high risk cardiac surgical patients. 4 years after ICU-admission, we assessed long term outcome of the subgroup of cardiac surgical patients (N=970) included in the original insulin trial (1) . cache = ./cache/cord-014987-nycbjqn6.txt txt = ./txt/cord-014987-nycbjqn6.txt === reduce.pl bib === id = cord-016280-d47e3art author = Friedberg, Joseph S. title = Pleura: Anatomy, Physiology, and Disorders date = 2008 pages = extension = .txt mime = text/plain words = 14487 sentences = 746 flesch = 44 summary = In addition to the discomfort, chest tube placement may be accompanied by a number of complications including empyema, lung injury and bleeding, and death." Therefore, coagulation profiles and immunocompetency should be taken into consideration for all patients considered for this procedure . If a large air leak is anticipated or if there is significant effusion associated with the pneumothorax, then a standard 28-French chest tube should be placed. Some of the indications for surgical treatment of a spontaneous pneumothorax include a second pneumothorax (ipsilateral recurrence or a new pneumothorax on the contralateral side); tension physiology; synchronous bilateral pneumothoraces; associated hemothorax (likely secondary to a tom adhesion and complicating approximately 5% of spontaneous pneumothoraces); failure of tube thoracostomy; and lifestyle factors. Chylothorax is an exudative effusion caused by disruption of the lymphatics in the chest, most commonly the thoracic duct, and subsequent drainage of chyle into the pleural space. cache = ./cache/cord-016280-d47e3art.txt txt = ./txt/cord-016280-d47e3art.txt === reduce.pl bib === === reduce.pl bib === id = cord-015334-8p124rwp author = nan title = ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date = 2008-06-11 pages = extension = .txt mime = text/plain words = 51143 sentences = 3291 flesch = 51 summary = Based on the results of the pharmacoeconomic analysis, development of clinical pharmacy and CIVAS for some drugs will be discussed with the paediatric department Background and Objective: Studies show that up to 38% of patients starting treatment with antidepressants fill only a single prescription at the pharmacy, apparently not accepting treatment. Main Outcome Measures: Data collected were: nurses' profile (age, length of service, competencies' self-assessment), knowledge on drugs prescribed to their patients (usage, administration, side-effects, drug interactions…), use of existing tools (i.e. drugs database) and possible tools to be developed by the pharmacy ward to help them in their daily practice. The objectives were:(1)To identify the most relevant minor ailments, agreeing on the specific criteria for referral to the GP.(2)To select the non-prescription drugs, with evidence of safety and effectiveness, for the treatment of the identified minor ailments Design: Qualitative study with an expert panel which was made up of 2 primary care physician from SEMFYC and six community pharmacists (two members of SEFAC and four members of GIAF-UGR). cache = ./cache/cord-015334-8p124rwp.txt txt = ./txt/cord-015334-8p124rwp.txt === reduce.pl bib === id = cord-015569-vy49r1zd author = nan title = Abstracts from the 45(th) Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7(th), 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University) date = 2012-05-17 pages = extension = .txt mime = text/plain words = 18852 sentences = 939 flesch = 51 summary = In this study, in order to test whether the cadherins are required for formation of synapse between gustatory nerve fibers and taste receptor cells, we have investigated expression patterns of cadherin superfamily in the taste buds. Therefore, this study aimed to examine differences in immunoreactivities under various tissue-preparing conditions in rat vallate taste buds for some typical markers of gustatory cells as follows: gustducin, type III inositol triphosphate receptor (IP 3 R3), synaptobrevin-2 (VAMP2), protein gene product 9.5 (PGP9.5), and neural cell adhesion molecule (NCAM). Mainly developing artificial-lipids-based taste sensors with global selectivity, our research group have studied for realization of Ã�taste-odor fusion biosensor system,Ã� which estimates quality (deliciousness and safety) of foods or beverages using several sensor outputs through analysis and evaluation of subjective-objective relation. As a first step, we conducted a series of human sensory tests to investigate perceptual similarities between odorants, and then compared the results with activity patterns evoked on the glomerular layer of the olfactory bulb in rats. cache = ./cache/cord-015569-vy49r1zd.txt txt = ./txt/cord-015569-vy49r1zd.txt === reduce.pl bib === id = cord-015348-qt0worsl author = nan title = Abstract date = 2010-07-30 pages = extension = .txt mime = text/plain words = 74085 sentences = 4714 flesch = 45 summary = However, the application of the compounds in clinical trials has revealed promising results only when predictive procedures have been available for determining which patients will benefit from targeting therapy, so-called eligibility or predictive tests, e.g. Her2 in breast cancer, KRAS and EGFR mutations in colorectal cancer and non-small cell lung cancer. Conclusion: We report on the development of a quantitative tissue-based immunohistochemical (IHC) methodology employing activation-specific antibodies against multiple components of the BCR signaling pathway that will assess the activity of the BCR pathway in formalin-fixed paraffinembedded primary DLBCLs. This approach will identify the subset of patient tumors that are actively signaling through the BCR pathway and, therefore, will predict therapeutic responsiveness to targeted inhibition of BCR signaling. Method: In our study, we investigate 120 cases diagnosed with invasive breast carcinoma in which we established microscopic characterization, immunohistochemical profiles (expression of proliferation markers, steroid receptors and Her2) and computer-assisted morphometric profiles by determining the mean values for nuclear area, cellular area and N/C ratio with Lucia Net Software. cache = ./cache/cord-015348-qt0worsl.txt txt = ./txt/cord-015348-qt0worsl.txt === reduce.pl bib === id = cord-016237-sk1wzghx author = Zhang, Chen title = Infectious Diseases date = 2018-09-07 pages = extension = .txt mime = text/plain words = 1491 sentences = 96 flesch = 29 summary = Patients with life-threatening pneumonia, especially those who are immunocompromised, are more likely to undergo lung biopsy to rule out unusual infections not easily diagnosed using conventional microbiologic methods and for which treatment strategies may be different. Nocardiosis ( Fig. 4 .5) occurs almost exclusively in immunocompromised patients and is caused by a gram-positive filamentous organism (Nocardia spp.) common in soil and as normal oral microflora. Some viral infections cause unique cytopathic changes that can be identified on routinely stained sections (Figs. Fungal infections more commonly seen in immunologically intact hosts may also occur in immunocompromised patients in whom the histologic findings may be more variable. It causes disease in both immunocompetent and immunocompromised patients and may be biopsied or excised because of its tendency to form a localized lung nodule. Pneumocystis pneumonia is affiliated with highly variable histologic features and therefore should always be in the differential diagnosis of infections in immunocompromised patients. cache = ./cache/cord-016237-sk1wzghx.txt txt = ./txt/cord-016237-sk1wzghx.txt === reduce.pl bib === id = cord-005814-ak5pq312 author = nan title = 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date = 1995 pages = extension = .txt mime = text/plain words = 179164 sentences = 12028 flesch = 56 summary = Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. cache = ./cache/cord-005814-ak5pq312.txt txt = ./txt/cord-005814-ak5pq312.txt === reduce.pl bib === id = cord-016248-dxk0i6t7 author = Papa, Joey C. title = Extracorporeal Membrane Oxygenation date = 2009 pages = extension = .txt mime = text/plain words = 6907 sentences = 357 flesch = 49 summary = Indications for support in patients with cardiac pathology are based on clinical signs of decreased peripheral perfusion, including hypotension, despite the administration of fl uid resuscitation and inotropes, oliguria (urine output < 0.5 ml/kg/h), an elevated arterial lactate, and a decreased SvO 2 . The advantages of VV and DLVV over VA ECMO include avoidance of arterial cannulation and permanent ligation of the carotid artery, maintaining pulsatile fl ow to the patient, continued blood fl ow to the lungs, and avoiding arterial emboli. Weaning and Decannulation: As the patient's underlying process improves, less blood fl ow is required to pass through the ECMO circuit in order to maintain adequate tissue oxygenation. According to the 2005 ELSO registry, 13.2% of neonates and 43% of pediatric patients treated with ECMO for respiratory failure required the use of inotropes while on bypass. The incidence of acute renal failure was 10% in neonates and 14% in pediatric patients on ECMO for respiratory support, with 10-15% requiring hemofi ltration or dialysis. cache = ./cache/cord-016248-dxk0i6t7.txt txt = ./txt/cord-016248-dxk0i6t7.txt === reduce.pl bib === id = cord-016211-8j8n9enn author = Lu, Puxuan title = Highly Pathogenic Avian Influenza date = 2015-04-30 pages = extension = .txt mime = text/plain words = 9573 sentences = 570 flesch = 50 summary = Statistical analysis has demonstrated that 60-70 % human infection of avian infl uenza is severe, which may clinically develop into acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Within 1 week after onset, the conditions may rapidly progress and deteriorate into acute lung injury, acute respiratory distress syndrome, pulmonary hemorrhage, pleural effusion, pancytopenia, multiple organ failure, shock, Reye syndrome, and secondary bacterial infection and septicemia. In severe cases of human infection by avian infl uenza, the patients develop pleuritis and pleural effusion at the middle or advanced stage, mostly 6-12 days after the onset. The patients experience typical symptoms of human infection with avian infl uenza, including fever with a body temperature above 38 °C, headache, general pain, fatigue, dry throat, and poor appetite. Some severe cases with human infection of avian infl uenza might develop rapid heart rate, nodal tachycardia, and acute heart failure at day 10-18 after the onset. cache = ./cache/cord-016211-8j8n9enn.txt txt = ./txt/cord-016211-8j8n9enn.txt === reduce.pl bib === id = cord-015946-biu5zxd1 author = Peng, Daizhi title = Research Advances in Biomarker for Sepsis date = 2016-11-16 pages = extension = .txt mime = text/plain words = 5100 sentences = 242 flesch = 40 summary = Most commonly proposed sepsis and infection biomarkers including C-reactive protein (CRP), procalcitonin (PCT) [5, 6] , cytokines (TNF-α, IL-1, IL-6, IL-10, osteopontin) [7, 8] , chemokines [macrophage migration inhibitory factor (MIF), high-mobility-group box 1 (HMGB1)] [9, 10] , soluble receptor [soluble triggering receptor expressed on myeloid cells 1 (sTREM-1), soluble urokinase-type plasminogen activator receptor (suPAR)] [11, 12] etc. When it comes to sepsis, by using genome-wide miRNA profiling with microarray in peripheral blood leukocytes and quantitative RT-PCR, Vasilescu [71] found that miR-150 levels were significantly reduced in both leukocytes and plasma of sepsis patients and had a negative correlation with the level of disease severity measured by the Sequential Organ Failure Assessment (SOFA) score, which made it a biomarker of early sepsis. As they were significantly correlated with disease severity, classical markers of inflammation and bacterial infection, as well as organ failure, high miR-133a levels were considered as independent biomarkers for unfavorable prognosis of critically ill patients. cache = ./cache/cord-015946-biu5zxd1.txt txt = ./txt/cord-015946-biu5zxd1.txt === reduce.pl bib === id = cord-016301-vqmqnipq author = Winnick, Aaron M. title = Elderly Transplant Recipients date = 2011-01-25 pages = extension = .txt mime = text/plain words = 11428 sentences = 504 flesch = 40 summary = Current success in transplanting kidneys into older recipients has quieted misconceptions within medical communities and the general public, among them the erroneous belief that advanced age alone prevents a successful surgical outcome, that the elderly patient with ESRD has a very limited life expectancy, and thus cannot receive a transplant, and that older recipients have poor results based upon outdated information from the previous era of transplantation and immunosuppression. While ECD kidneys carry a relative risk of graft failure greater than 1.7 compared to a reference group of donors aged 10-39 years without any of the above three conditions, elderly recipients of ECD kidneys were found to have a survival benefit compared with waiting-list candidates (RR = 0.75; 95% CI 0.65-0.86; p < 0.0001) [8] . One study evaluated 91 transplant recipients over the age of 60 over a 13-year span and reported a 10-year patient survival of 35% in the elderly group and 60% in the younger patients ( p < 0.05). cache = ./cache/cord-016301-vqmqnipq.txt txt = ./txt/cord-016301-vqmqnipq.txt === reduce.pl bib === id = cord-016110-mlwe7fzz author = Specks, Ulrich title = Pulmonary Manifestations of Vasculitis date = 2014-05-05 pages = extension = .txt mime = text/plain words = 7833 sentences = 415 flesch = 36 summary = In the context of a vasculitis syndrome, the lungs and lower airways can be affected by three major pathologic processes: (1) infl ammatory cell infi ltration and necrosis of the pulmonary parenchyma; (2) infl ammation of the tracheobronchial tree often leading to stenoses; and (3) pulmonary capillaritis causing diffuse alveolar hemorrhage (DAH). DAH can result from a variety of underlying or associated conditions that cause a disruption of the alveolarcapillary basement membrane integrity including immunological infl ammatory conditions causing immune-complex deposition or capillaritis (e.g., anti-GBM disease (Goodpasture's), systemic lupus erythematosus (SLE), ANCA-associated vasculitis), direct chemical/toxic injury (e.g., from toxic or chemical inhalation, abciximab use, all-trans-retinoic acid, trimellitic anhydride, or smoked crack cocaine), physical trauma (e.g., pulmonary contusion), and increased vascular pressure within the capillaries (e.g., mitral stenosis or severe left ventricular failure) (Table 10 .1 ). cache = ./cache/cord-016110-mlwe7fzz.txt txt = ./txt/cord-016110-mlwe7fzz.txt === reduce.pl bib === id = cord-015884-mtpbzgr9 author = Haynes, Alice title = Current Practices for Infection Prevention in the Hospital Settings date = 2013-08-06 pages = extension = .txt mime = text/plain words = 3217 sentences = 152 flesch = 46 summary = The CDC, in cooperation with the Healthcare Infection Control Practices Advisory Committee (HICPAC), established Standard Precautions to address the prevention of the spread of infectious agents in healthcare settings and are the result of combining the key components from Universal Precautions and Body Substance Isolation along with the understanding that all blood and body fl uids, except sweat, are potentially infectious, and inanimate objects are potentially contaminated with infectious agents, therefore are capable of being reservoirs in the chain of transmission of infectious agents [ 11 , 12 ] . Standard Precautions group together infection prevention practices consisting of the use of Personal Protective Equipment (PPE), such as gowns, gloves, masks, goggles or face shields, and the performance of hand hygiene, washing hands with soap and water, especially when they are visibly soiled, or using an alcohol-based hand sanitizer. cache = ./cache/cord-015884-mtpbzgr9.txt txt = ./txt/cord-015884-mtpbzgr9.txt === reduce.pl bib === id = cord-015922-5wwy0m2k author = Marty, Francisco M. title = Infection in the Hematopoietic Stem Cell Transplant Recipient date = 2008 pages = extension = .txt mime = text/plain words = 10254 sentences = 489 flesch = 33 summary = Other prophylactic strategies commonly utilized in HSCT patients include acyclovir to prevent herpes simplex virus (HSV) and VZV reactivation, fluoroquinolones [5] to prevent gram-negative sepsis and fluconazole to prevent yeast infection. It has been suggested that EBV viral load surveillance in peripheral blood be carried out in high risk patients (those with primary EBV infection, anti-T cell antibody therapy for GVHD, HLA-mismatched or T cell-depleted HSCT recipients), with decreased immunosuppression +/− antiviral therapy (acyclovir or ganciclovir) carried out in the setting of high viral loads [1, 4, 41, 42] . Infliximab use in patients with severe graftversus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study cache = ./cache/cord-015922-5wwy0m2k.txt txt = ./txt/cord-015922-5wwy0m2k.txt === reduce.pl bib === id = cord-016208-u12ngkpc author = Andersen, Bjørg Marit title = Intensive Patient Treatment date = 2018-09-25 pages = extension = .txt mime = text/plain words = 4579 sentences = 334 flesch = 50 summary = Intensive care units (ICUs) are treating hospital's poorest patients that need medical assistance during the most extreme period of their life. Intensive patients are treated with extensive invasive procedures, which may cause a risk of hospital infections in 10–30% of the cases. The hospital's management should provide resources and written guidelines regarding infection control work, proper patient/care ratio, sufficient patient areas, isolation capacity and documented competence. Intensive care unit (ICU) should have a large enough area and furnished for a good, safe and effective infection protection [1] . Recent studies indicate that patients in separate ICU rooms will have fewer hospital infections and thus a lower risk of fatal outcome [72, 73] . An outbreak of multidrug-resistant Pseudomonas aeruginosa associated with increased risk of patient death in an intensive care unit Single rooms may help to prevent nosocomial blood stream infection and cross-transmission of methicillin-resistant Staphylococcus aureus in intensive care units cache = ./cache/cord-016208-u12ngkpc.txt txt = ./txt/cord-016208-u12ngkpc.txt === reduce.pl bib === === reduce.pl bib === id = cord-016135-44pgjah8 author = Sen, Ayan title = Postoperative Management of Composite Tissue Graft Transplantation date = 2016-06-03 pages = extension = .txt mime = text/plain words = 2618 sentences = 160 flesch = 42 summary = In this chapter, we will discuss general and specifi c postoperative management of patients following CTA. Face transplantation is a complex and long surgery that is associated with signifi cant perioperative challenges, and multiple postoperative complications. Postoperative severe graft edema is expected in most patients and head elevation at 30-45° will promote venous drainage and prevent VAP [ 1 ] . The most severe infections occur during times of over-immunosuppression, such as the induction phase or management of acute rejection. Maintenance immunosuppression involves a regime of tacrolimus, mycophenolate mofetil, and prednisone, and must be closely followed up for the duration of the patient's or allograft's life. The fi rst hand transplant recipient lost his graft due to rejection from noncompliance. Management of graft failure involves amputation followed by use of prosthesis or another transplant. Helping hands: caring for the upper extremity transplant patient cache = ./cache/cord-016135-44pgjah8.txt txt = ./txt/cord-016135-44pgjah8.txt === reduce.pl bib === id = cord-014976-546zaoxn author = nan title = Publication only date = 2006-03-08 pages = extension = .txt mime = text/plain words = 51926 sentences = 2983 flesch = 53 summary = In order to evaluate if malignant and non malignant hematological diseases quantitatively and qualitatively affect BM derived MSCs, bone marrow from children with acute lymphoblastic leukemia (ALL diagnosis n=9, different phases of treatment n=29, end of therapy n=10), idiopathic thrombocytopenic purpura (n=16), autoimmune neutropenia (n=12) and control patients (solid tumors without BM involvement, n=30) was harvested and the mononuclear cell (MNC) fraction isolated. Case: In our hospital a total of 3 patients with relapsed Hodgkin's disease underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) from an HLA-identical sibling. We report a case of a young male patient of 19 years old with aggressive MS who was treated with a high-dose immunosuppressive regimen (HDIS) using myeloablation followed by autologous blood stem cell transplantation (ASCT) that has induced a dramatic and long-lasting remission of the disease. cache = ./cache/cord-014976-546zaoxn.txt txt = ./txt/cord-014976-546zaoxn.txt === reduce.pl bib === id = cord-015640-zdwmxaz3 author = Tong, C. Y. W. title = Clinical Virology in NICU, PICU and AICU date = 2011-08-10 pages = extension = .txt mime = text/plain words = 6051 sentences = 356 flesch = 44 summary = Viruses are significant causes of nosocomial infections, particularly in intensive care unit (ICU) where seriously ill and vulnerable patients are being cared for. Adherence to effective infection control measures (hand hygiene, enteric precautions; Table 20 .3), as well as adequate staffing and patient cohorting/ isolation can therefore help prevent or manage an outbreak [41] . Neonates and immunocompromised patients can shed the virus for a prolonged time over months, which emphasises the need for rigorous adherence to effective infection control measures (Table 20. Postexposure prophylaxis (PEP) should therefore be offered to all health care workers who have significant exposure to blood or body fluid from a patient known to be at high risk of or to have HIV infection. Preliminary estimation of risk factors for admission to intensive care units and for death in patients infected with A(H1N1)2009 influenza virus cache = ./cache/cord-015640-zdwmxaz3.txt txt = ./txt/cord-015640-zdwmxaz3.txt === reduce.pl bib === id = cord-014687-0am4l5ms author = nan title = SPR 2012 date = 2012-03-29 pages = extension = .txt mime = text/plain words = 98592 sentences = 5600 flesch = 43 summary = This presentation will focus on recent developments that have lead to a better understanding of the embryopathogenesis for fibropolycystic liver diseases (including choledochal cysts and Caroli disease), histopathological findings that have led to new classification systems for of pediatric vascular anomalies, technological advances and contrast agents in magnetic resonance imaging that are useful to characterize and limit the differential diagnosis of hepatic masses. Disclosure: Dr. Annapragada has indicated that he is a stock holder and consultant for Marval Biosciences Inc. Paper #: PA-067 Cardiovascular Image Quality Using a Nanoparticle CT Contrast Agent: Preliminary Studies in a Pig Model Rajesh Krishnamurthy, Radiology, Texas Children's Hospital, rxkrishn@texaschildrens.org; Ketan Ghaghada, Prakash Masand, Abhay Divekar, Eric Hoffman, Ananth Annapragada Purpose or Case Report: Image quality in a separate study using a long circulating, liposomal-based nanoscale blood pool iodinated contrast agent (NCTX) suggests clinical utility in pediatrics, potentially reducing difficulties in contrast-CT of children with congenital heart disease (CHD) including the size of intravenous cannula, need for accurate timing, inability to simultaneously opacify multiple targets of interest (requiring repeated contrast administration and/or repeated imaging). cache = ./cache/cord-014687-0am4l5ms.txt txt = ./txt/cord-014687-0am4l5ms.txt === reduce.pl bib === id = cord-016498-j72vrvqf author = Fong, I. W. title = Issues in Community-Acquired Pneumonia date = 2020-03-07 pages = extension = .txt mime = text/plain words = 8280 sentences = 372 flesch = 38 summary = In a recent study of 70 children <5 years of age hospitalized for CAP without an identifiable etiology and 90 asymptomatic controls, metagenomics [next-generation sequencing] and pan-viral PCR were able to identify a putative pathogen in 34% of unidentifiable cases from nasopharyngeal and oropharyngeal swabs [18] . More recently in Britain, 325 adult patients with confirmed pneumonia admitted to two tertiary-care hospitals had cultures and comprehensive molecular testing [multiplex real-time PCR for 26 respiratory viruses and bacteria] from sputum [96%] and endotracheal aspirate [4% or 13 cases] [32] . Incidence of respiratory viral infections detected by PCR and real-time PCR in adult patients with community-acquired pneumonia: a meta-analysis Severe thinness is associated with mortality in patients with community-acquired pneumonia: a prospective observational study Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial cache = ./cache/cord-016498-j72vrvqf.txt txt = ./txt/cord-016498-j72vrvqf.txt === reduce.pl bib === id = cord-016601-gp259urb author = Bonadonna, Lucia title = Analysis of Microorganisms in Hospital Environments and Potential Risks date = 2017-03-24 pages = extension = .txt mime = text/plain words = 3523 sentences = 192 flesch = 32 summary = Hospital environments are characterized by high infective risk, firstly cause of the compromised immunologic conditions of the patients that make them vulnerable to bacterial, viral, parasitological and fungal opportunistic infections (D'Alessandro et al. The potential transmission of biological matter during surgery operations and medical treatments of infected individuals makes hospital environments strongly designated to become easily contaminated with spread of pathogens among patients (Baglioni and Capolongo 2002) . In addition, technological devices such as hydraulic, heating and air-conditioning systems may represent a potential source of bacteria, fungi (moulds), virus and other organisms if not adequately designed and submitted to a planned preventive maintenance. These difficulties are exacerbated in hospitals where the patient health status, the activities that take place and the potential spread of pathogenic biological agents increase the level of complexity respect to other indoor environments. cache = ./cache/cord-016601-gp259urb.txt txt = ./txt/cord-016601-gp259urb.txt === reduce.pl bib === === reduce.pl bib === id = cord-016127-tbot0fc9 author = Hurtado, F. J. title = Sepsis: Clinical Approach, Evidence-Based at the Bedside date = 2009-11-19 pages = extension = .txt mime = text/plain words = 4875 sentences = 315 flesch = 44 summary = Since 2002 the Surviving Sepsis Campaign was introduced with the initial goal of increasing clinicians' awareness about severe sepsis mortality and to improve outcome in this patient population. Despite the fact that most of these recommendations were not supported by high levels of evidence, they represented the international consensus on the best available standards of care for the management of sepsis. Mortality increases according to the presence of shock, and metabolic markers like arterial lactate are useful to characterize disease severity and the response to treatment [8] . The current management of severe sepsis and septic shock aims to control infection, achieve hemodynamic stabilization, modulate the immune response, and provide metabolic and organ support. The SSC is a global initiative that involves several international organizations with the common objective of elaborating evidence-based guidelines and recommendations for the management of severe sepsis and septic shock. Early goal-directed therapy in the treatment of severe sepsis and septic shock cache = ./cache/cord-016127-tbot0fc9.txt txt = ./txt/cord-016127-tbot0fc9.txt === reduce.pl bib === id = cord-016105-jkaxemmb author = Nakao, Mutsuhiro title = Prevention and Psychological Intervention in Depression and Stress-Related Conditions date = 2011 pages = extension = .txt mime = text/plain words = 4505 sentences = 202 flesch = 37 summary = Through such quasi experience-based studies, medical students can not only acquire knowledge and develop the desired professional attitudes and behaviors but can also come to learn about the psychological and social problems actually experienced by patients. The case-method approach also offers the advantage of using actual cases to learn about the multidimensional issues involved in various aspects of medical practice, such as drawing on knowledge as the basis of actions, understanding the backgrounds of patients, and maintaining awareness of personal motivations and ethical concerns. Based on the need for these procedures, the proposed problem-solving paradigm includes the following phases: (1) defining the problem, (2) measuring its magnitude, (3) understanding key determinants, (4) developing prevention/intervention strategies, (5) setting policy/priorities, (6) identifying the best solution, and (7) implementing and evaluating the solution. Our experiences with CBT have identified problems with using this approach to treat depression in Japan and have underscored issues that require further consideration to improve the effectiveness of treatment offered in actual clinical settings. cache = ./cache/cord-016105-jkaxemmb.txt txt = ./txt/cord-016105-jkaxemmb.txt === reduce.pl bib === id = cord-016177-fz48wydz author = Bezek, Sarah title = Emergency Triage of Highly Infectious Diseases and Bioterrorism date = 2020-01-03 pages = extension = .txt mime = text/plain words = 4381 sentences = 189 flesch = 35 summary = Emergency medical services are a key element in health systems for the evaluation and treatment of patients exposed to highly infectious diseases or bioterrorism agents. • Developing a case definition for person under investigation • Standardized questions for dispatchers to identify possible infection • Preparation for and evaluation upon arrival on scene by EMS personnel • Precautions while transporting patients and contacting appropriate receiving hospital • Monitoring of potentially exposed EMS personnel • Maintenance of transportation vehicles and equipment • Decontamination processes Similar peer-reviewed frameworks have been proposed for a pandemic of influenza and other respiratory illnesses [4] . Appropriate implementation of these principles can potentially help prevent further spread of disease or agent exposure, initiate appropriate care of ill patients, protect essential EMS responders, and promote efficient use of healthcare resources. cache = ./cache/cord-016177-fz48wydz.txt txt = ./txt/cord-016177-fz48wydz.txt === reduce.pl bib === id = cord-016235-2lhrkmrv author = Roden, Anja C. title = Lung date = 2010-05-17 pages = extension = .txt mime = text/plain words = 12865 sentences = 674 flesch = 35 summary = Unlike the situation with heart transplant recipients, chronic vascular rejection in lung transplants has not resulted in graft loss; however, some patients develop pulmonary hypertension particularly those with BOS [92, 111] . However, based on the link between acute rejection and development of BOS, surveillance transbronchial biopsies in asymptomatic lung transplant recipients has become common practice in many large lung transplantation centers because evidence suggests that patients who have multiple episodes of low grade (A1) lesions within the first 12 months posttransplantation develop early onset BOS. A study [49] in which surveillance transbronchial biopsies were performed at 3, 6, 9, and 12 weeks posttransplantation, at the time of symptoms, and for follow-up of acute rejection or CMV pneumonia showed that patients who develop acute small airways rejection within the first year after transplantation are at risk of development of BOS at 1.76, 3.3, and 5.5 years after detection of B3/ B4 lesion (by 1996 ISHLT criteria, see Table 7 .2), B2 lesion or B0/B1 lesion, respectively. cache = ./cache/cord-016235-2lhrkmrv.txt txt = ./txt/cord-016235-2lhrkmrv.txt === reduce.pl bib === id = cord-016372-opojt70e author = DiMarco, Ross F. title = Postoperative Care of the Cardiac Surgical Patient date = 2010 pages = extension = .txt mime = text/plain words = 26961 sentences = 1673 flesch = 42 summary = Ninety percent of all postoperative open-heart patients demonstrate a transient low cardiac output (LCO) related to the release of oxygen free radicals in response to the induced inflammatory state of cardiopulmonary bypass, or from ischemic/reperfusion injury as a result of cardioplegic arrest. Doses greater than 2 mcg/ min (>0.03 mcg/kg/min) produce effects that cause vasoconstriction with an increased SVR potentially decreasing cardiac output further as well as increasing myocardial oxygen demand. 88, 89 The indications for IABP counterpulsation are perioperative ischemia, mechanical complications of myocardial infarction (such as acute mitral regurgitation, ventricular septal defect, and cardiogenic shock), postoperative low cardiac output states not responsive to moderate doses of inotropic agents, and for the acute deterioration of myocardial function to provide temporary support or a bridge to transplantation. Inotropic effect of triiodothyronine in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: an initial experience in patients undergoing open-heart surgery cache = ./cache/cord-016372-opojt70e.txt txt = ./txt/cord-016372-opojt70e.txt === reduce.pl bib === id = cord-015370-4jfgsic7 author = nan title = 55th Annual Meeting of the Austrian Society of Surgery: Graz, June 25—27, 2014 date = 2014-06-03 pages = extension = .txt mime = text/plain words = 46551 sentences = 4856 flesch = 48 summary = Obwohl die fehlerhafte Aufklärung durch Ärzte unter Juristen schon länger ein "Renner" ist, hat sich in der Praxis häufig noch nicht herumgesprochen, wie und vor allem wann der Patient vor einem chirurgischen Eingriff aufgeklärt werden muss. Objective: This study aimed to investigate the effect of single and combined baseline concentrations of b vitamins on postoperative survival of vascular surgery patients over a time of 8.5 years in a region without folate fortification. Laparoscopic resection of 2 gastric duplication cysts in a pediatric patient: report of a case Ergebnisse: Mit Ausnahme von 6 der Mädchen mit 32 funktionellen Zysten, die konservativ behandelt wurden, wurden alle anderen Tumoren nach Durchführung einer Schnellschnittuntersuchung reseziert, bei 2 Mädchen mit malignen Tumoren war nur ein Tumordebulking möglich. Methods: Twenty-two patients, who underwent endoscopic band removal between June 2002 and December 2013, were ret-und in manchen Fällen ist die Amputation der einzige Ausweg, wenn auch diese sorgfältig gegen Risiko und Nutzen einer komplexen Rekonstruktion abgewogen werden muss, um im Endeffekt dem Patienten ein paar Jahre mit hoher Lebensqualität zu ermöglichen. cache = ./cache/cord-015370-4jfgsic7.txt txt = ./txt/cord-015370-4jfgsic7.txt === reduce.pl bib === id = cord-016460-39yniw0t author = Ben-Chetrit, Eldad title = Colchicine date = 2018-07-31 pages = extension = .txt mime = text/plain words = 9575 sentences = 532 flesch = 45 summary = • Rat sarcoma homolog gene family, member A (Rho A) protein is a peptide which controls the action of GTPases thereby affects tubulin dynamics • Pyrin is a specific immune sensor (pattern recognition receptor-PRR) for bacterial modifications of Rho and GTPases • Activation of RhoA inhibits pyrin activity while inactivation of RhoA causes over activation of pyrin resulting in increased production of interleukin (IL)-1, thereby enhancing inflammation • Colchicine may activate RhoA by guanine nucleotide exchange factor (GEF)-H1, thereby suppressing pyrin activity and inflammation • Colchicine also disrupts microtubules structure reducing neutrophils membrane elasticity and relaxation, thereby preventing their extravasation from the blood vessels to the inflammatory site cache = ./cache/cord-016460-39yniw0t.txt txt = ./txt/cord-016460-39yniw0t.txt === reduce.pl bib === id = cord-016413-lvb79oxo author = Efthimiou, Petros title = Adult-Onset Still’s Disease date = 2018-07-14 pages = extension = .txt mime = text/plain words = 6126 sentences = 315 flesch = 40 summary = Adult-onset Still's disease (AOSD) is a rare systemic, autoinflammatory disorder that often presents in adolescence and early adulthood with fever, rash, and polyarthritis. Mutation of perforin and the MUNC13-4 genes have been seen in patients with macrophage activation syndrome (MAS), a known severe, life-threatening complication of AOSD [3] . Patients who have the chronic articular disease pattern can present with joint erosions making the differential diagnosis from RA problematic, especially in the absence of systemic signs and symptoms. Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France Effectiveness of first-line treatment with recombinant interleukin-1 receptor antagonist in steroid-naive patients with new-onset systemic juvenile idiopathic arthritis: results of a prospective cohort study Clinical manifestations of adult-onset Still's disease presenting with erosive arthritis: association with low levels of ferritin and Interleukin-18 cache = ./cache/cord-016413-lvb79oxo.txt txt = ./txt/cord-016413-lvb79oxo.txt === reduce.pl bib === id = cord-016871-1mlamf20 author = Streiff, Agathe title = Hemorrhage and Transfusions in the Surgical Patient date = 2012-10-30 pages = extension = .txt mime = text/plain words = 9056 sentences = 429 flesch = 46 summary = In acutely bleeding patients, massive transfusion protocols are often activated in order to ef fi caciously restore blood volume and hemostasis and thawed plasma is critical to their success [ 5, 6 ] . DCR is also supported by fi ndings from the US Army's Institute of Surgical Research, which demonstrated improvement in outcomes in severely bleeding patients who were transfused in ratios of products similar to whole blood. However, some groups have shown that those patients receiving less than massive transfusion levels may still bene fi t from higher plasma to red blood cell ratios [ 20 ] . Silver et al.'s randomized, double-blind, placebo-controlled trial investigated the role of epoetin alfa, a recombinant erythropoietin, in reducing the RBC transfusion requirement of long-term acute care patients, thereby reducing risks associated with transfusions [ 29 ] . cache = ./cache/cord-016871-1mlamf20.txt txt = ./txt/cord-016871-1mlamf20.txt === reduce.pl bib === id = cord-016300-vw11c2wt author = Jain, Kewal K. title = Biomarkers of Pulmonary Diseases date = 2017-09-18 pages = extension = .txt mime = text/plain words = 5578 sentences = 271 flesch = 42 summary = Association of ECM turnover with severity and outcome of COPD has been assessed in a prospective, observational, multicenter study, Global Initiative for Chronic Obstructive Lung Disease grades II to IV, and serum samples were analyzed at stable state, during exacerbation as well as 4 weeks after exacerbation (Stolz et al. A study has revealed that serum levels of the neuroendocrine activity biomarker chromagranin A (CgA) are increased in male smokers with impaired lung function, and are associated with both respiratory symptoms and the degree of airway obstruction (Sorhaug et al. Although the aim of management of patients with asthma is to control their symptoms and prevent exacerbations and morbidity of the disease, optimal management may require assessment and monitoring of biomarkers, i.e., objective measures of lung dysfunction and inflammation. Several biomarkers have been assessed following treatment with corticosteroids including measures of lung function, peripheral blood and sputum indices of inflammation, exhaled gases and breath condensates. cache = ./cache/cord-016300-vw11c2wt.txt txt = ./txt/cord-016300-vw11c2wt.txt === reduce.pl bib === id = cord-016572-6fu5s89c author = Hage, Chadi A. title = Endemic mycosis date = 2005 pages = extension = .txt mime = text/plain words = 9004 sentences = 571 flesch = 43 summary = All three illnesses occur in normal hosts, although histoplasmosis and coccidioidomycosis are also major opportunistic mycoses in patients with depressed cell-mediated immunity, and especially in patients with acquired immunodeficiency syndrome (AIDS) [4] , [5] . Histoplasmosis, blastomycosis and coccidioidomycosis are major T-cell opportunistic infections, as demonstrated by the very aggressive course seen in patients with AIDS, in whom T-cell deficiency is most severe. The most severe form of progressive disseminated histoplasmosis (PDH) occurs in patients with AIDS with profound T-cell dysfunction [21] . By that time, most patients have either recovered or have required other more invasive methods of diagnosis because of rapidly worsening disease There are two ways to make a rapid diagnosis of PDH, sampling and examination of likely infected tissue with the use of special stains and the use of the ultrasensitive assay for fungal antigens. cache = ./cache/cord-016572-6fu5s89c.txt txt = ./txt/cord-016572-6fu5s89c.txt === reduce.pl bib === id = cord-015024-2xzc0uc5 author = nan title = ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 84393 sentences = 5234 flesch = 52 summary = We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). cache = ./cache/cord-015024-2xzc0uc5.txt txt = ./txt/cord-015024-2xzc0uc5.txt === reduce.pl bib === id = cord-016308-qzkcwrit author = Cochran, Christina L. title = Neonatal Emergencies date = 2015-11-06 pages = extension = .txt mime = text/plain words = 2764 sentences = 323 flesch = 44 summary = • Initial signs of respiratory distress include tachypnoea and increased work of breathing (Table 11 .1 ) • As distress progresses, newborns are at risk of developing respiratory failure and apnoea. • RDS presents in the fi rst days of life (Table 11 .2 ) • Bronchiolitis is a clinical diagnosis based on physical exam and history [ 3 ] . • Consider hypoglycaemia, metabolic dysfunction, hyperbilirubinemia, congenital heart conditions, and neurologic dysfunction when assessing a patient with the above features. • Most cases of hyperbilirubinemia are physiologic, or secondary to normal delayed conjugation and excretion of bilirubin in the newborn, though pathologic aetiologies must be considered. • Management of Hirschsprung's Disease is reviewed in Table 11 .11 • In the case of toxic megacolon, provide resuscitation as clinically indicated and IV antibiotics • Consider thyroid studies in patients with clinical signs or maternal history of antithyroid antibodies. cache = ./cache/cord-016308-qzkcwrit.txt txt = ./txt/cord-016308-qzkcwrit.txt === reduce.pl bib === id = cord-017012-yl0vanuh author = Herberg, Jethro title = Infectious Diseases and the Kidney date = 2009 pages = extension = .txt mime = text/plain words = 23980 sentences = 1301 flesch = 34 summary = Renal involvement in infectious diseases may occur by a variety of mechanisms: direct microbial invasion of the renal tissues or collecting system may take place in conditions such as staphylococcal abscess of the kidney as a result of septicemic spread of the organism or as a consequence of ascending infection; damage to the kidney may be caused by the systemic release of endotoxin or other toxins and activation of the inflammatory cascade during septicemia or by a focus of infection distant from the kidney; ischemic damage may result from inadequate perfusion induced by septic shock; the kidney may be damaged by activation of the immunologic pathways or by immune complexes resulting from the infectious process. However, in addition to this post-infection immunologically mediated disorder, in recent years there have been increasing reports of GAS causing acute renal failure as part of an invasive infection with many features of the staphylococcal toxic shock syndrome (28) . cache = ./cache/cord-017012-yl0vanuh.txt txt = ./txt/cord-017012-yl0vanuh.txt === reduce.pl bib === id = cord-014996-p6q0f37c author = nan title = Posters_Monday_12 October 2009 date = 2009-08-06 pages = extension = .txt mime = text/plain words = 85190 sentences = 5288 flesch = 54 summary = Data recorded on admission were the patient demographics with, acute physiology and chronic health evaluation II score (APACHE II), and type of admission; during intensive care stay, sepsis-related organ failure assessment score (SOFA) and clinical concomitant factors and conditions. For each severe septic patient the following data was registered: time delay, APACHE II and SOFA scores at ICU admission, diagnosis, the rate of compliance with the resucitation and management bundles, microbiological data, evolution of levels of serum lactate, empiric antibiotic therapy, length of stay and mortality in ICU. Sepsis and septic shock remain the most important causes of acute kidney injury (AKI) in critically ill patients and account for more than 50% of cases of acute renal failure (ARF) in intensive care units (ICU). There were no significant differences between the demographic data (sex, age) or the data on admission to intensive care (APACHE II score, ratio of medical to surgical patients) and duration of mechanical ventilation between the two groups. cache = ./cache/cord-014996-p6q0f37c.txt txt = ./txt/cord-014996-p6q0f37c.txt === reduce.pl bib === id = cord-015368-a0qz4tb9 author = nan title = 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date = 2007 pages = extension = .txt mime = text/plain words = 86620 sentences = 6042 flesch = 51 summary = Surgical treatment and evaluation, complications, short and long term patency of our patients were compared to interventional techniques and international literature. The aim of the study was to investigate: i) relevant and combined determinants of the development, management and outcome of a representative patient cohort (n ¼ 9.991) with acute appendicitis enrolled in a prospective unicenter study through a time period of 27 years (middle Europe), and ii) the frequency and impact of specific categories (e.g., characteristics of the medical history, clinical and intraoperative findings, complications), correlation and relative risk factors of the disease and its prognosis. From 01=1997 until 12=2006 198 TEM procedures were performed in 194 patients, 104 males, 90 females, mean age was 68.9 years (38-91), the median hospital stay was 8 days . No conversion to open technique had to be performed, no postoperative surgical complications were observed, one patient died 4 weeks postoperative due to liver failure following esophageal varices bleeding. cache = ./cache/cord-015368-a0qz4tb9.txt txt = ./txt/cord-015368-a0qz4tb9.txt === reduce.pl bib === id = cord-016814-tf17dpo5 author = Enes, Sara Rolandsson title = Clinical Application of Stem/Stromal Cells in COPD date = 2019-08-07 pages = extension = .txt mime = text/plain words = 10751 sentences = 521 flesch = 40 summary = Despite increasing number of preclinical studies demonstrating that systemic MSC administration can prevent or treat experimental COPD and emphysema, clinical studies have not been able to reproduce the preclinical results and to date no efficacy or significantly improved lung function or quality of life has been observed in COPD patients. performed a Phase I, prospective, open-label study (NCT01306513) where they aimed to assess the safety and feasibility of intravenously infused bone marrow-derived MSCs for ten patients with severe emphysema that had serial lung volume reduction surgeries (LVRS). Current clinical trials that aimed to evaluate the effect of MSC administration in COPD patients differ in a wide range of factors such as routes of administration, number of MSC administered, number of administrations, use of fresh MSCs or culture-expanded MSCs. Furthermore, all the investigations discussed above, were phase I-II studies that were underpowered in order to detect potential efficacy and no improved pulmonary function or respiratory quality of life was observed. cache = ./cache/cord-016814-tf17dpo5.txt txt = ./txt/cord-016814-tf17dpo5.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-016559-tqd7m2i1 author = Zheng, Yi title = Application in Medicine Systems date = 2014-10-28 pages = extension = .txt mime = text/plain words = 19346 sentences = 778 flesch = 48 summary = Danshen has the function of effectively dilating the coronary artery, increasing coronary blood flow, reducing heart rate, inhibiting platelet aggregation and thrombopoiesis induced by platelet activation factors, promoting the recovery of injured cardiac muscle, increasing cardiac contractility, and protecting cardiac muscle cells; thus it can be widely applied in treating the diseases of the circulation system. [7] reported the application of 0.5/ 250 ml of puerarin and glucose injection combined with 16 ml of CDI in the treatment of 44 patients with coronary heart disease and angina pectoris, and the results showed that in the treatment group there were 31 patients with a marked effect, 10 patients with an effect, 3 patients without effect, and the total effective rate was 93.2 %. Patients with cerebral hemorrhage were treated with CDI, and the rates of recovery and significant improvement in the treatment group were significantly better than those in the control group, and no side effects were observed. cache = ./cache/cord-016559-tqd7m2i1.txt txt = ./txt/cord-016559-tqd7m2i1.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-016476-78r0rsio author = Jani, Meghna title = Management of the Rheumatoid Arthritis Patient with Interstitial Lung Disease date = 2017-11-29 pages = extension = .txt mime = text/plain words = 15238 sentences = 641 flesch = 35 summary = Several risk factors of leflunomide-induced pneumonitis have been reported in small numbers of patients in case series and retrospective studies including preexisting lung disease [32, 35, 36] , a prescribed loading dose, smoking, low body weight [32] and increased C-reactive protein, hypoalbuminaemia, hypoxia and lymphopaenia [36] . Whilst experience of using abatacept in the context of pre-existing ILD is limited, a case report of rapid-onset interstitial pneumonia 2 days post initiation of Administration, MHRA medicines and healthcare products regulatory agency, NA data not available, RA rheumatoid arthritis a Includes cases reported as idiopathic pulmonary fibrosis, pulmonary fibrosis and pulmonary toxicity treatment has been described in a Japanese patient [103] . Association of disease activity with acute exacerbation of interstitial lung disease during tocilizumab treatment in patients with rheumatoid arthritis: a retrospective, case-control study cache = ./cache/cord-016476-78r0rsio.txt txt = ./txt/cord-016476-78r0rsio.txt === reduce.pl bib === === reduce.pl bib === id = cord-016478-gpl0zbvd author = Barry, Maura title = Cytopenias in Transplant Patients date = 2018-12-08 pages = extension = .txt mime = text/plain words = 5636 sentences = 259 flesch = 32 summary = The differential diagnosis for anemia after solid organ transplant includes hemolysis, drug toxicities, iron deficiency, infection, posttransplant lymphoproliferative disorder, graft-vs.-host disease, and hemophagocytic syndrome. Sirolimus and calcineurin inhibitors such as tacrolimus and cyclosporine have been shown in renal and lung transplant recipients to cause hemolytic anemia, thrombotic thrombocytopenic purpura, and atypical hemolytic uremic syndrome [15] [16] [17] . While this etiology is more often identified as a drug-related phenomenon, particularly due to the immunosuppressants required to prevent organ rejection (see next section), there have been multiple case reports associating CMV infection as a trigger of TMA in the posttransplant setting [53, 54] . When this is identified, numerous case studies in multiple different organ systems (lung, liver, kidney solid organ transplant) have reported that changing from one CI to another (tacrolimus to cyclosporine or vice versa) or to another class of medication such as sirolimus or mycophenolate mofetil can prevent further episodes of TMA from occurring [61] [62] [63] [64] . cache = ./cache/cord-016478-gpl0zbvd.txt txt = ./txt/cord-016478-gpl0zbvd.txt === reduce.pl bib === id = cord-017040-4zajnrsf author = Rihana, Nancy title = Skin Infections date = 2019-08-11 pages = extension = .txt mime = text/plain words = 6486 sentences = 408 flesch = 36 summary = Pseudomonas aeruginosa, usually a nosocomial pathogen has emerged as a common cause of infection in immunocompromised patients; most often in neutropenic leukemics during chemotherapy. The dermatologic manifestations of Pseudomonas sepsis include ecthyma gangrenosum, hemorrhagic bullae, necrotizing/gangrenous or bullous cellulitis, painful vesicular lesions, and small papules on the trunk resembling rose spots of typhoid fever, grouped petechiae, erysipelas-like lesions with hyperesthesia, erythematous or violaceous subcutaneous painful nodules, and necrotizing or malignant external otitis [3] . In the immunocompromised, the typical history of previous trauma or surgery is absent, thus cutaneous Mycobacteria infection are most probably the result of hematogenic dissemination, resulting in multiple skin lesions. Although aspergillus is one of the most common etiologies of invasive fungal infections in patients with underlying malignancies, dermatologic manifestations occurs in less than 5% of cases [41, 42] . Cutaneous lesions typically present in cases of disseminated disease and often mimic other dermatologic infections due its' ability to manifest with many skin findings including papules, plaques, nodules, ulcers or pustules. cache = ./cache/cord-017040-4zajnrsf.txt txt = ./txt/cord-017040-4zajnrsf.txt === reduce.pl bib === id = cord-016960-xhzvp35g author = Berencsi, György title = Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy date = 2012-03-08 pages = extension = .txt mime = text/plain words = 17693 sentences = 1045 flesch = 42 summary = The importance of maternal anti-idiotypic antibodies are believed to prime the fetal immune system with epitopes of etiologic agents infected the mother during her whole life before pregnancy and delivery. Neonatal lupus is a model of passively acquired autoimmunity in which a mother-, who may have systemic lupus erythematosus (SLE) or Sj€ ogren's syndrome (SS) or may be entirely asymptomatic-synthesizes antibodies to SSA/Ro and/or SSB/ La ribonucleoproteins that enter the fetal circulation via trophoblast FcRn receptors and presumably cause tissue injury (Lee 1990 ) as mentioned above. Teplizumab (CD3-specific, hOKT3g1-Ala-Ala), a humanized Fc mutated anti-CD3 monoclonal antibody induced tolerance, on the progression of type 1 diabetes in patients with recent-onset disease even 2 years after the first diagnosis (Herold et al. Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells cache = ./cache/cord-016960-xhzvp35g.txt txt = ./txt/cord-016960-xhzvp35g.txt === reduce.pl bib === id = cord-014464-m5n250r2 author = Sole-Violan, J title = Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date = 2013-03-19 pages = extension = .txt mime = text/plain words = 98961 sentences = 5553 flesch = 54 summary = Results In preliminary analysis of categorical data, a signifi cantly (Fisher exact test) greater proportion of patients with compared with without the following fi ndings did not survive; history of alcohol use (P = 0.05); the presence of lethargy (P = 0.01), confusion (P = 0.03), nausea (P = 0.04), abdominal pain (P = 0.02), or the need for vasopressors (P = 0.002), oxygen, mechanical ventilation, or steroids (all P = 0.004) at presentation; and excessive bleeding at surgery (P = 0.01). Methods To prospectively re-evaluate the normal range and to analyze the potential impact of biometric data on ICG-PDR, we measured ICG-PDR (i.v. injection of 0.25 mg/kg ICG; LiMON, Pulsion, Munich, Introduction Mixed venous oxygen saturation (SVO 2 ) represents a well-recognized parameter of oxygen delivery (DO 2 )-consumption (VO 2 ) mismatch and its use has been advocated in critically ill patients in order to guide hemodynamic resuscitation [1] and oxygen delivery optimization. cache = ./cache/cord-014464-m5n250r2.txt txt = ./txt/cord-014464-m5n250r2.txt === reduce.pl bib === id = cord-016982-qt25tp6t author = Fong, I. W. title = Litigations for Unexpected Adverse Events date = 2010-11-30 pages = extension = .txt mime = text/plain words = 8372 sentences = 453 flesch = 48 summary = The statement of claim alleged the following: (1) isoniazid was directly responsible for the plaintiff's fulminant hepatitis which resulted in the need for a liver transplant, (2) informed consent was never obtained to prescribe the drug, as the plaintiff was never counseled on the adverse effects, nor given a choice of treatment, (3) use of the isoniazid was never indicated, as the patient had no symptoms or signs of active disease, (4) the physician should have realized that the positive Mantoux test was due to a previous BCG vaccination as a child (the defendant was informed of this fact) and therefore there was no need to treat the plaintiff for latent tuberculosis. cache = ./cache/cord-016982-qt25tp6t.txt txt = ./txt/cord-016982-qt25tp6t.txt === reduce.pl bib === id = cord-017217-zjab7o2o author = Ali, Yousaf title = Self Assessment Questions date = 2008-01-08 pages = extension = .txt mime = text/plain words = 9298 sentences = 715 flesch = 52 summary = A 47-year-old patient with Crohn's disease presents for evaluation of new onset arthritis. Although the patient has not had prior thromboses she is at high risk for developing antiphospholipid antibody syndrome in view of these blood tests. A 19-year-old previously healthy student is evaluated for new onset fever, joint pain, and rash. Her lab work reveals leukocytosis with lymphocytic predominance, normal renal function, mild transaminitis, and low serum albumin. Yousaf Ali, Self Assessment Questions in Rheumatology, DOI: 10.1007/ 978-1-59745-497-1, Humana Press, a part of Springer Science + Business Media, LLC 2009 A 55-year-old female with chronic renal failure is seen for evaluation of lower extremity edema and ankle pain. This 41-year-old patient presents with a 4-year history of recurrent sinusitis in the setting of a positive P-ANCA, destructive nasopharyngeal mass, and ophthalmoplegia.The differential diagnosis includes infection with a refractory organism, such as mucormycosis or tuberculosis, malignancy, midline granuloma, or vasculitis. cache = ./cache/cord-017217-zjab7o2o.txt txt = ./txt/cord-017217-zjab7o2o.txt === reduce.pl bib === id = cord-017142-vx3rgs4r author = Nair, Ranjit title = What the Intensivists Need to Know About Critically Ill Myeloma Patients date = 2019-07-09 pages = extension = .txt mime = text/plain words = 9343 sentences = 460 flesch = 36 summary = Suspicion of cast nephropathy in newly diagnosed myeloma patients with serum FLC above 1000 mg/L should be high, especially if associated selective proteinuria composed of FLC/BJP exists, as the degree of renal injury is usually related to tumor load [55] . MM patients are at high risk for cardiac complications secondary multiple factors including an older age group of patients with underlying comorbidities, concurrent kidney involvement, MM-associated deposition disease, and/or anti-MM drug-related side effects. Cardiac amyloidosis can be clinically silent initially, and a MM patient presenting with progressive dyspnea, worsening edema with evidence of heart failure, or dysrhythmia presenting as syncope or hypotensive event requires a thorough work-up to rule out coexisting amyloid disease. Immunosuppression is mediated by disease-and treatment-related factors including decreased ratio of functional to dysfunctional immunoglobulins, defects in antibody opsonization, steroid-related T cell defects, secondary immunodeficiency related to chemotherapy, restricted pulmonary reserve from thoracic rib fractures and opiate use, mucosal damage, indwelling catheters, and presence of renal failure [53, 88, 100] . cache = ./cache/cord-017142-vx3rgs4r.txt txt = ./txt/cord-017142-vx3rgs4r.txt === reduce.pl bib === === reduce.pl bib === id = cord-009567-osstpum6 author = nan title = Abstracts Oral date = 2008-04-23 pages = extension = .txt mime = text/plain words = 131214 sentences = 7728 flesch = 53 summary = Introduction: Previously, it has been demonstrated that FOXP3, a gene required for the development and function of regulatory T cells, was highly expressed in the graft during cardiac rejection, suggesting infiltration of regulatory T cells in the transplanted organ during an allogeneic response. Efficacy and safety parameters assessed at follow-up included: acute rejection; patient and graft survival; renal function, vital signs, basic lab results and immunosuppressive regimen for the patients 10 years after completion of the original study. We analyzed, for the first time, the expression of TLR4 in PBMC from kidney recipients with contrasted situations: operational tolerance and chronic immune-mediated rejection (Banff 2005), compared to patients with normal histology and stable graft function, non transplant patients with renal failure and healthy volunteers. cache = ./cache/cord-009567-osstpum6.txt txt = ./txt/cord-009567-osstpum6.txt === reduce.pl bib === === reduce.pl bib === id = cord-017350-rwqaw5ii author = Venet, F. title = Monitoring Immune Dysfunction in Septic Patients: Toward Tailored Immunotherapy date = 2010-03-10 pages = extension = .txt mime = text/plain words = 3966 sentences = 182 flesch = 36 summary = This review will focus on the immune dysfunctions described so far in septic patients regarding monocytes and T lymphocytes (as examples of innate and adaptive immune cells) and their potential use as biomarkers on a routine standardized basis for prediction of adverse outcome or occurrence of secondary nosocomial infections and for guidance of putative immunotherapy. With that said, the down modulation of CD14 expression on monocytes after septic shock (a cell surface marker decreased during monocyte apoptosis) tends to confirm this increased apoptotic process especially because its downregulation was more pronounced in patients who were not going to survive [12] . A growing body of evidence has now confirmed that the lymphocyte-mediated immune response may be dysfunctional after severe sepsis and may play a major role in the development of a state of immunosuppression in such patients [1, 18] . cache = ./cache/cord-017350-rwqaw5ii.txt txt = ./txt/cord-017350-rwqaw5ii.txt === reduce.pl bib === id = cord-017302-xez0zso3 author = Stephens, R. Scott title = ICU Complications of Hematopoietic Stem Cell Transplant, Including Graft vs Host Disease date = 2019-07-24 pages = extension = .txt mime = text/plain words = 5226 sentences = 289 flesch = 33 summary = Hematopoietic stem cell transplant (HSCT) has become an essential therapeutic modality in the treatment of malignant and non-malignant hematologic disease. Allogeneic transplants are associated with more morbidity and mortality than autologous transplants, and are further categorized based on conditioning regimen (myeloablative [MA] vs non-myeloablative [NMA]), donor-recipient relation (related vs unrelated), HLA matching (full match vs haploidentical vs mismatched), and stem cell source (bone marrow, peripheral blood, umbilical cord blood). Refinement of transplant techniques over the last 2 decades has dramatically decreased transplant-related mortality, but approximately 15% of HSCT patients require critical care [10] and earlier ICU admission has been associated with improved survival rates [11, 12] . Outcomes of stem cell transplant patients with acute respiratory failure requiring mechanical ventilation in the United States Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease cache = ./cache/cord-017302-xez0zso3.txt txt = ./txt/cord-017302-xez0zso3.txt === reduce.pl bib === id = cord-015306-us58wwmp author = nan title = Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date = 2013-06-21 pages = extension = .txt mime = text/plain words = 71194 sentences = 4580 flesch = 53 summary = The incidence of renal involvement varies from 20 to 60% and there have been some reports showing that nephritis might be related to an older age at onset, persistent purpura (> 1 month), severe abdominal pain, and relapsing disease.Recently, several studies have shown that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, resulting in the formation of the circulating immune complexes and their mesangial deposition causing renal injury in HSP nephritis and serum galactose-deficient IgA1 levels were highly inherited in children with HSP nephritis.Regarding the treatment of HSP, one randomized double-blinded controlled study recently showed that patients with abdiminal pain or arthralgia may benefit from early treatment with prednisone, but the drug has not been proven to be capable of preventing the development of renal symptoms. cache = ./cache/cord-015306-us58wwmp.txt txt = ./txt/cord-015306-us58wwmp.txt === reduce.pl bib === id = cord-017309-pt27efu1 author = Gupta, G. S. title = Selectins and Associated Adhesion Proteins in Inflammatory disorders date = 2012-03-20 pages = extension = .txt mime = text/plain words = 25423 sentences = 1303 flesch = 40 summary = Activation of endothelial cells (EC) with different stimuli induces the expression of E-and P-selectins, and other adhesion molecules (ICAM-1, VCAM-1), involved in their interaction with circulating cells. Accordingly, population studies have explored the association of ischaemic heart disease with gene polymorphisms of the inflammatory molecules: tumor necrosis factors (TNF) a and b, transforming growth factors (TGF) b1 and 2, P and E selectins, and platelet endothelial cell adhesion molecule (PECAM) 1. Endothelial dysfunction in type 2 diabetic patients is associated with inflammation, increased levels of circulating soluble adhesion molecules (VCAM-1 and E-selectin), and inducing production of ROS, and urinary albumin excretion (Potenza et al. The A 561 C polymorphism of E-selectin gene may be associated with disease progression in patients with chronic HBV infection and control the expression of plasma soluble levels, while the G 98 T polymorphism may be related to fibrotic severity in Chinese population (Wu et al. cache = ./cache/cord-017309-pt27efu1.txt txt = ./txt/cord-017309-pt27efu1.txt === reduce.pl bib === id = cord-017016-twwa9djm author = Tomashefski, Joseph F. title = Aspiration, Bronchial Obstruction, Bronchiectasis, and Related Disorders date = 2008 pages = extension = .txt mime = text/plain words = 20053 sentences = 1313 flesch = 40 summary = These occult aspirations may lead to interstitial fibrosis, and perhaps account for the 20% to 54 % incidence of associated and unexplained pulmonary fibrosis in patients with esophageal abnormalities, most commonly hiatal hernia or simple reflux,39,40 The role of reflux in asthma, chronic bronchitis, chronic cough, recurrent pneumonia, cystic fibrosis, and sudden infant death syndrome has been reviewed by Allen et al. 130 In their reviews, Phillips and Rao l3l and Penner and colleagues130 note that similar predisposing factors as those with community-acquired pneumonia, such as aspiration and abscess formation, pertain to this entity, but the location helps distinguish it from the other typical sites of aspiration, When in the upper lobes, it appears to progress through necrotizing pneumonia with thrombosis of arteries (pulmonary and bronchial) and veins, [129] [130] [131] Although not strictly abiding by the foregoing definition (of localization in upper lobe), in one case total unilateral lung gangrene was attributed to hilar vessel involvement following treatment of a massive hilar recurrence of Hodgkin's disease. cache = ./cache/cord-017016-twwa9djm.txt txt = ./txt/cord-017016-twwa9djm.txt === reduce.pl bib === id = cord-017324-l3d3t4wh author = DjukanoviĆ, Ljubica title = Balkan nephropathy date = 2008 pages = extension = .txt mime = text/plain words = 6838 sentences = 425 flesch = 42 summary = Balkan nephropathy does not spread beyond its already defined foci; the disease is distributed mosaically : non-endemic villages exist in the most affected regions, and there are spared families and households in the most affected settlements. Optic microscopic, immunofluorescent and electron microscopic studies of renal biopsies in children aged 5-15 from affected families in endemic regions failed to detect any Balkan nephropathy related changes [79] . The diagnosis of Balkan nephropathy is now established according to the first two criteria (residence in endemic village and positive family history) suggested by Danilović [106] , presence of tubular proteinuria and ruling out other renal diseases. Although no specific indicators of Balkan nephropathy have been recognized, epidemiological data, familial history as well as clinical characteristics of the disease enable differential diagnosis. However, recent studies indicated that patients with Balkan nephropathy are at increased risk for the development of upper urothelial tumors in both native and transplanted kidneys [117] . cache = ./cache/cord-017324-l3d3t4wh.txt txt = ./txt/cord-017324-l3d3t4wh.txt === reduce.pl bib === id = cord-017374-clctlm5l author = Diamantaki, Eleni title = Acute Respiratory Failure Before ICU Admission: A Practical Approach date = 2017-06-28 pages = extension = .txt mime = text/plain words = 4304 sentences = 202 flesch = 30 summary = Other frequent causes include cardiogenic and noncardiogenic pulmonary edema (acute respiratory distress syndrome [ARDS]), antineoplastic therapy (chemotherapy, radiation therapy)-induced lung injury, cancer-related medical disorders (such as venous thromboembolism, transfusionrelated acute lung injury), and direct involvement of the respiratory system by malignancy and progression of underlying disease. HRCT yields an overall sensitivity and negative predictive value of 90%, in identifying the cause of ARF in cancer patients with lung infiltrates, but low specificity and positive predictive value [7] . Pulmonary toxicity of antineoplastic agents, known as drug-induced toxicity (DIT), is a common cause of respiratory failure in oncologic patients and should be included in the differential diagnosis of ARF in patients who are on or have been treated with antineoplastic agents. Cardiogenic pulmonary edema (CPE) should always be included in the differential diagnosis of acute respiratory failure in oncologic patients, in particular when chemotherapy with cardiotoxic drugs has been preceded. cache = ./cache/cord-017374-clctlm5l.txt txt = ./txt/cord-017374-clctlm5l.txt === reduce.pl bib === id = cord-017337-vq3edhxn author = Vincent, Jean-Louis title = PIRO: The Key to Success? date = 2009 pages = extension = .txt mime = text/plain words = 3809 sentences = 176 flesch = 47 summary = Building on a system that had emerged at the Fifth Toronto Sepsis Roundtable held in Toronto, Canada, in 2000 [6] , the sepsis defi nitions conference participants, therefore, proposed the PIRO system [5] , which can classify patients on the basis of their predisposing conditions, the nature and extent of the infection, the nature and magnitude of the host response, and the degree of concomitant organ dysfunction. The PIRO system for the grading of sepsis uses clinical and laboratory parameters to aid diagnosis and patient classifi cation, with each element being divided according to the degree of involvement (e.g., infection can be classifi ed as localized, extended, or generalized; immune response can be classifi ed as limited, extensive, or excessive; organ dysfunction can be classifi ed as mild, moderate, severe). Improved classifi cation of septic patients using the PIRO system may, thus, facilitate the development and evaluation of clinical trials of sepsis therapies and will also encourage further study into the pathophysiology and epidemiology of sepsis. cache = ./cache/cord-017337-vq3edhxn.txt txt = ./txt/cord-017337-vq3edhxn.txt === reduce.pl bib === id = cord-017184-1ewi3dka author = nan title = Primary Immunodeficiencies date = 2008 pages = extension = .txt mime = text/plain words = 44492 sentences = 2035 flesch = 45 summary = In this disease, microorganism phagocytosis by polymorphonuclear (PMN) leukocytes appears annulled, and the patient is subject to severe infections supported by capsular bacteria: the deficiency, described in association with severe and recurrent infantile infections [175, 485, 487] , depends on the lack of mannose-binding lectin (MBL) [487] , its Primary Immunodeficiencies a possible atopy dependence on IgA underproduction rather than on IgE hyperproduction ( Fig. 4.1 ): in children with levels of IgA at the minimum normal level, and followed from birth until the age of 18-23 months, a greater severity of atopic manifestations and an increased cumulative incidence of asthma, AD and otitis media with effusion (OME) were observed compared to controls. cache = ./cache/cord-017184-1ewi3dka.txt txt = ./txt/cord-017184-1ewi3dka.txt === reduce.pl bib === id = cord-017392-ja9b5vy9 author = Waterer, G. W. title = Adjunctive and Supportive Measures for Community-Acquired Pneumonia date = 2010-05-20 pages = extension = .txt mime = text/plain words = 4461 sentences = 232 flesch = 35 summary = Randomized, controlled trials have shown corticosteroids reduce mortality in AIDS patients with Pneumocystis carinii pneumonia and significant hypoxia, if instituted at or prior to the onset of anti-pneumocystis therapy [8, 9] . Anecdotally, corticosteroids are frequently used in the setting of severe fungal pneumonia, particularly due to Histoplasmosis [11, 12] , and a small controlled trial of 55 patients supported their use in miliary tuberculosis [13] . Following the success of pre-antibiotic corticosteroids in children with meningitis [14] , Marik and colleagues [15] studied the effect of a single dose of hydrocortisone (10 mg/kg) 30 min prior to antibiotic therapy in a small randomized placebo controlled trial of 30 adult patients with severe CAP (SCAP). Once respiratory failure has ensued, supportive measures such as patient positioning and differential lung ventilation can improve oxygenation at no additional risk in some patients, particularly those with severe unilateral pneumonia. cache = ./cache/cord-017392-ja9b5vy9.txt txt = ./txt/cord-017392-ja9b5vy9.txt === reduce.pl bib === id = cord-017531-fm8gl5b3 author = Andersen, Bjørg Marit title = Scenarios: Serious, Infectious Diseases date = 2018-09-25 pages = extension = .txt mime = text/plain words = 3604 sentences = 288 flesch = 53 summary = All transport of infectious patients from the place of arrival to the hospital should take place in ambulances using the same infection control regime as for the individual infectious disease (contact infection, airborne infection, strict isolation); see isolation regimes; Chaps. • Ambulance staff and other personnel use the contact and airborne infection regime when picking up and transporting a patient. Short-time airborne isolation of exposed cases until the infection state is clarified/effect of antibacterial therapy 82.5.6 Anthrax After Staying in Turkey, Sick on the Plane Home 82.5.6.1 Patient: Strict Isolation-Air Pressure Isolate with Pressure [21, 22] Example: Two out of six people who have been on family visits in Turkey for a week, on farms with goats and skin production, are acutely ill on the plane home with cough, shortness of breath and fever. Less severe disease: isolation of index case and close contacts • Registering: All exposed persons are registered (name, address, telephone number) and followed up. cache = ./cache/cord-017531-fm8gl5b3.txt txt = ./txt/cord-017531-fm8gl5b3.txt === reduce.pl bib === id = cord-017489-ftz9190a author = Richards, Guy A. title = Viruses in the Intensive Care Unit (ICU) date = 2005 pages = extension = .txt mime = text/plain words = 5792 sentences = 330 flesch = 44 summary = Pneumonia is the most common complication, which occurs in high-risk patients including those with comorbid illness such as cardiovascular or pulmonary disease, diabetes, renal failure, immunosuppression, the elderly, or residents of nursing homes. A study performed in our ICU indicates that corticosteroids may dramatically alter the course of the most severe disease and should be considered in addition to antiviral therapy along with appropriate supportive care in any previously well patient with life threatening varicella pneumonia (42). Patients with HIV or AIDS (acquired immunodeficiency syndrome) who are hospitalized with chickenpox appear to be at high risk for developing varicella pneumonia, which manifests in a similar clinical fashion to that in immunocompetent individuals. In another study of 68 adult patients admitted with measles diagnosed on clinical and serological grounds, 9 required intensive care, six mechanical ventilation for approximately 15 days, and two deaths occurred. cache = ./cache/cord-017489-ftz9190a.txt txt = ./txt/cord-017489-ftz9190a.txt === reduce.pl bib === id = cord-017420-tjwxec77 author = Stephens, R. Scott title = Neutropenic Fever in the Intensive Care Unit date = 2019-07-09 pages = extension = .txt mime = text/plain words = 5865 sentences = 290 flesch = 34 summary = Neutropenic patients with septic shock tend to have more frequently positive blood cultures, more fungal infections, more multidrug-resistant bacterial infections, and higher mortality rates than immunocompetent patients. Accordingly, current guidelines for the management of neutropenic fever and sepsis recommend monotherapy with an antipseudomonal beta-lactam unless otherwise dictated by circumstances such as patient allergies, the presence of resistant organisms, or refractory hemodynamic instability [28, 57, 61] . The use of surveillance rectal cultures, performed pre-transplant and then weekly after HSCT, to identify patients with MDR infections and allow immediate initiation of antibiotic therapy targeted against MDR organisms may result in better outcomes [26] . Patients with neutropenia and sepsis are at high risk of developing multi-organ failure, particularly the acute respiratory distress syndrome (ARDS) [4, 5] . Neutropenic sepsis continues to confer a poor prognosis, with recent data suggesting an approximate 46% mortality rate in patients with hematologic malignancies who develop septic shock [7, 39, 47] . cache = ./cache/cord-017420-tjwxec77.txt txt = ./txt/cord-017420-tjwxec77.txt === reduce.pl bib === id = cord-017393-kx8kmdej author = Herbers, Alexandra title = Acute Myelogenous Leukemia and Febrile Neutropenia date = 2009-08-31 pages = extension = .txt mime = text/plain words = 13295 sentences = 566 flesch = 31 summary = Despite numerous clinical studies, since the 1970s, no single empirical antibiotic regimen has been shown to be superior for initial treatment of patients who become febrile during a neutropenic episode after therapy with chemotherapy drugs for hematological malignancies (see Table 5 -2) [4, 9, [34] [35] [36] [37] [38] [39] [40] [41] [42] [43] [44] . Similarly, bacteremias due to Staphylococcus aureus, Pseudomonas aeruginosa, and Clostridium species as well as candidemias are more frequently encountered in patients with acute leukemia who suffer from neutropenic enterocolitis or typhlitis, the most serious disturbance of the delicate balance between mucosal damage and microbial flora in the setting of prolonged exposure to antibiotics after intermediate or high-dose cytarabine chemotherapy. In addition, if a persistently neutropenic patient has no complaints and displays no clinical, radiological, or laboratory evidence of infection, cessation of antibiotic therapy or a change to oral antimicrobials should be considered after 4 days without symptoms. cache = ./cache/cord-017393-kx8kmdej.txt txt = ./txt/cord-017393-kx8kmdej.txt === reduce.pl bib === id = cord-017534-0ai8chbu author = Andersen, Bjørg Marit title = Background Information: Isolation Routines date = 2018-09-25 pages = extension = .txt mime = text/plain words = 9640 sentences = 603 flesch = 51 summary = There is an increased need of isolates for patients with infections, especially due to pulmonary tuberculosis, MRSA, VRE, Clostridium difficile (CD), multiresistant gram-negative bacteria and other "multidrug-resistant organisms" (MDRO) [23, 24, 36, 37, [48] [49] [50] [51] . In 2009, a European investigation was done as regards the number of "high-level isolation rooms" (HIRs), i.e. airborne infection isolation units with negative pressure (not defined) with at least 6 air changes per hour and sluice (anteroom) [61] . CDC defines contact isolation, using gown and gloves when in contact with patients infected with resistant bacteria like MRSA and other MDROs (multidrug-resistant organisms), and single rooms are recommended [19] . Spread of pathogenic infectious agents through the air and droplets requires a defined negative pressure ventilation isolate and a system which reduces airborne infection in the patient's room. cache = ./cache/cord-017534-0ai8chbu.txt txt = ./txt/cord-017534-0ai8chbu.txt === reduce.pl bib === === reduce.pl bib === id = cord-017569-fv88n70v author = Hewlett, Angela title = Viral Hemorrhagic Fever Preparedness date = 2017-09-10 pages = extension = .txt mime = text/plain words = 11178 sentences = 457 flesch = 40 summary = Although each facility may wish to tailor the composition of the HICS team to their own particular needs, and each situation may require adjustment, key team members would typically include logisticians to plan to replenish PPE supply levels and address waste management issues, a public information officer (PIO), medical technical specialists to include infectious disease physicians and nurse leaders to manage the clinical care of the patient and staffing within the patient care unit, a laboratorian to address testing logistics and specimen transport challenges, a clinical research expert to facilitate the use of experimental therapies when necessary, a nurse concierge or other dedicated individual to support family needs, and a behavioral health expert to address staff well-being as well as the psychological and emotional needs of patients and families. The HLCC facilities in the United States that admitted patients infected with Ebola virus disease (EVD) have well developed teams of nurses who are able to provide skilled and effective patient care within their isolation units. cache = ./cache/cord-017569-fv88n70v.txt txt = ./txt/cord-017569-fv88n70v.txt === reduce.pl bib === id = cord-017461-xw02c7u5 author = Kauffman, Carol A. title = Fungal Infections date = 2009-02-02 pages = extension = .txt mime = text/plain words = 5446 sentences = 294 flesch = 40 summary = Candida species are the most common cause of opportunistic fungal infections, and bloodstream infections are usually treated with fluconazole or an echinocandin antifungal agent. The endemic fungi, Histoplasma capsulatum, Coccidioides species, and Blastomyces dermatitidis, cause infection when the mold form is dispersed and inhaled from the environment in those specific areas of the country in which these organisms flourish. Amphotericin B is used for initial treatment of severe histoplasmosis, coccidioi­domycosis, and blastomycosis; itraconazole is the therapy of choice for most mild to moderate infections due to these endemic mycoses. Serious fungal infections can be separated into two major categories: The opportunistic mycoses that include candidiasis, cryptococcosis, and invasive mold infections such as aspergillosis and zygomycosis, and the endemic mycoses, which in the United States, includes histoplasmosis, blastomycosis, and coccidioidomycosis. cache = ./cache/cord-017461-xw02c7u5.txt txt = ./txt/cord-017461-xw02c7u5.txt === reduce.pl bib === id = cord-017516-qbksb83c author = Si, Yain-Whar title = Hidden Cluster Detection for Infectious Disease Control and Quarantine Management date = 2009-09-30 pages = extension = .txt mime = text/plain words = 3358 sentences = 158 flesch = 46 summary = Our prototype Infectious Disease Detection and Quarantine Management System (IDDQMS), which can identify and trace clusters of infection by mining patients' history, is introduced in this paper. The SARS (Severe Acute Respiratory Syndrome) outbreak in 2003 and recent world-wide avian flu infections have contributed to the urgent need to search for efficient methods for prevention and control of highly infectious diseases. Given this background, this research aims to develop a decision support system which can be used to locate the source of an outbreak by mining clusters and communities from the patients' past activities (testimonies) using techniques from infectious disease control, information visualization, and database management systems. IDDQMS (see Figure 1 ) consists of four modules; information extraction, data analysis, hidden cluster detection, and quarantine management. In this paper, we have described our novel prototype system on Infectious Disease Detection and Quarantine Management, which can be used to identify and trace clusters of infection by mining patients' history. cache = ./cache/cord-017516-qbksb83c.txt txt = ./txt/cord-017516-qbksb83c.txt === reduce.pl bib === === reduce.pl bib === id = cord-017772-zpf1xjqi author = Walter, James M. title = Thrombocytopenia in the Intensive Care Unit date = 2019-07-24 pages = extension = .txt mime = text/plain words = 4577 sentences = 279 flesch = 43 summary = In general, ICU patients who develop thrombocytopenia are sicker than patients with normal platelet counts, with higher illness severity scores, more need for vasoactive infusions, and more organ dysfunction [8, 9] . TMAs are a diverse group of disorders that can be classified broadly as primary (thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, drug-mediated, etc.) or secondary to a systemic disorder (disseminated intravascular coagulation, severe hypertension, hemolysis with elevated liver enzymes and low platelets during pregnancy, etc.) [23] . The diagnosis of DIC should be suspected in any critically ill patient with thrombocytopenia, abnormal coagulation parameters (e.g., a prolonged prothrombin and partial thromboplastin times), MAHA, and laboratory evidence of fibrinolysis (e.g., an elevated d-dimer and reduced fibrinogen) [38] . Indeed, a recent systematic review did not identify a single high-quality study that investigated the impact of prophylactic platelet transfusions on bleeding rates in critically ill patients [72] . cache = ./cache/cord-017772-zpf1xjqi.txt txt = ./txt/cord-017772-zpf1xjqi.txt === reduce.pl bib === id = cord-017581-6lubp7io author = Glass, Daniel M. title = Respiratory Diseases of Pregnancy date = 2019-07-24 pages = extension = .txt mime = text/plain words = 2515 sentences = 163 flesch = 43 summary = Pregnant patients can suffer from the same respiratory diseases as the general population in addition to unique syndromes of pregnancy (such as pre-eclampsia and tocolytic induced pulmonary edema, and pregnancy induced cardiomyopathy). Low pulmonary reserves that arise from reductions in functional residual capacity (caused by the gravid uterus and changes in the chest wall morphology) [1] and increased oxygen consumption make pregnant women develop hypoxemia more rapidly during apnea [4] . The most common causes of non-cardiogenic acute pulmonary edema in pregnancy are, fluid overload, preeclampsia, tocolytic agents, sepsis, trauma or following aspiration of gastric contents [6, 7] . A partial pressure of carbon dioxide within the normal range of 36-40 on an arterial blood gas can be an early sign of imminent respiratory failure in the gravid patient. Some of the risk factors for pneumonia in pregnancy include anemia, asthma, antepartum corticosteroids given to enhance fetal lung maturity, and the use of tocolytic agents to induce labor [27] . cache = ./cache/cord-017581-6lubp7io.txt txt = ./txt/cord-017581-6lubp7io.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-017883-6a4fkd5v author = Dutta, Ankhi title = Infection Prevention in Pediatric Oncology and Hematopoietic Stem Cell Transplant Recipients date = 2018-07-16 pages = extension = .txt mime = text/plain words = 6243 sentences = 301 flesch = 35 summary = There are various factors which contribute to the increased susceptibility to infections in pediatric hematology/oncology (PHO) and HSCT patients, most prominent of them being disruption of cutaneous and mucosal barriers (oral, gastrointestinal, etc.), microbial gastrointestinal translocation, defects in cell-mediated immunity, and insufficient quantities and inadequate function of phagocytes. Based upon such data in adults, the IDSA Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer state that fluoroquinolone prophylaxis should be considered for high-risk patients with prolonged severe neutropenia [20] . Though some authors suggest that antibiotic prophylaxis should be considered in children undergoing induction chemotherapy for ALL, there is currently insufficient data to inform definitive guidelines for antibiotic prophylaxis to prevent bacterial infections in pediatric oncology patients [19] [20] [21] . cache = ./cache/cord-017883-6a4fkd5v.txt txt = ./txt/cord-017883-6a4fkd5v.txt === reduce.pl bib === id = cord-017784-4r3fpmlb author = Foccillo, Giampiero title = The Infections Causing Acute Respiratory Failure in Elderly Patients date = 2019-08-06 pages = extension = .txt mime = text/plain words = 3573 sentences = 170 flesch = 31 summary = Severe community-acquired pneumonia and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are causes of acute respiratory failure (ARF) in elderly patients. This process termed immunosenescence or immune dysregulation, together changes in lung function who occur with advancing age, play a critical role in the manifestation of age-related pulmonary diseases such as infections (i.e., pneumonia), chronic obstructive pulmonary disease (COPD), and increased the risk for develop sepsis [1] . Triggering causes of ARF in advanced aged patients are especially acute heart decompensation, severe community-acquired pneumonia (CAP), acute exacerbations of COPD (AECOPD), and pulmonary embolism. Lower respiratory tract infections, including pneumonia and exacerbation of chronic obstructive pulmonary disease, are among the most common causes of ARF in elderly people and the most important cause of hospitalization. Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease cache = ./cache/cord-017784-4r3fpmlb.txt txt = ./txt/cord-017784-4r3fpmlb.txt === reduce.pl bib === === reduce.pl bib === id = cord-017862-9fkjjmvf author = Smith, Roger P. title = Respiratory Disorders date = 2007 pages = extension = .txt mime = text/plain words = 6045 sentences = 342 flesch = 51 summary = Only 12-25% of all "sore throats" seen by physicians have a true pharyngitis-most are simple viral upper respiratory infections such as the common cold. infl uenzae, Staphylococcus aureus, Legionella pneumophila, and Allergens such as pollens, molds, animal dander, dust mites, and cockroaches Irritants such as strong odors and sprays, chemicals, air pollutants, tobacco smoke, and cold air Viral or sinus infections including colds, pneumonia, and sinusitis Exercise, especially in cold, dry air Gastroesophageal refl ux disease (GERD), a condition in which stomach acid fl ows back up the esophagus Medication and foods Emotional anxiety others) is the most common source of infection for most patients. Infl uenza, rubeola and rubella, Mycoplasma pneumonia, group A β-hemolytic streptococcal infections, and allergic rhinitis may all be confused with the common cold and should be considered when appropriate. When a common cold has lasted for 7-10 days and is no better or worse, acute bacterial sinusitis may have developed and additional medical care may be required. cache = ./cache/cord-017862-9fkjjmvf.txt txt = ./txt/cord-017862-9fkjjmvf.txt === reduce.pl bib === === reduce.pl bib === id = cord-018182-lleti89n author = Kassutto, Stacey M. title = Care of the Surgical ICU Patient with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension date = 2016-10-09 pages = extension = .txt mime = text/plain words = 6222 sentences = 310 flesch = 32 summary = Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are frequently encountered in the intensive care unit (ICU). Important differential diagnoses in patients with severe dyspnea and/or impending respiratory failure include congestive heart failure, acute coronary syndrome, pulmonary embolism, cardiac arrhythmia, pneumothorax, pleural effusion, acute infectious processes such as bacterial or viral pneumonia, and exacerbations of other underlying pulmonary conditions such as interstitial lung disease. Given their complexity, the use of RHC and ongoing invasive hemodynamic monitoring is recommended for patients with evidence of RV failure requiring ICU admission, particularly in the setting of vasoactive agent titration [32] . Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbations of chronic obstructive pulmonary disease Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease Noninvasive positive pressure ventilation in the setting of severe acute exacerbations of chronic obstructive pulmonary disease: more effective and less expensive cache = ./cache/cord-018182-lleti89n.txt txt = ./txt/cord-018182-lleti89n.txt === reduce.pl bib === id = cord-017946-fa4ehlb0 author = Lawless, Ryan A. title = Adjuncts to Resuscitation date = 2018-05-26 pages = extension = .txt mime = text/plain words = 5937 sentences = 298 flesch = 36 summary = This chapter will focus on adjuncts to damage control resuscitation (DCR) including massive transfusion protocols, the "other" tenets of damage control resuscitation, hypertonic saline, tranexamic acid, pharmacologic resuscitation, Factor VIIa, and prothrombin complex, and viscoelastic testing. Looking at the incorporation of the other two principles (permissive hypotension and minimizing crystalloids) into a mature trauma center already incorporating a transfusion strategy approaching whole blood, investigators found an improvement in survival among emergent laparotomy patients [4] . The authors noted a significantly improved mortality compared to that predicted by the Trauma Related Injury Severity Score (TRISS) in patients who received fibrinogen concentrate during their initial resuscitation. Animal models of liver injury associated hemorrhagic shock have shown decreased blood loss, increased mean arterial pressure, and significantly higher hemoglobin levels with vasopressin administration compared to standard crystalloid resuscitation [74] . A randomized, placebo-controlled study (AVERT Shock) is currently underway to investigate the potential benefit of vasopressin administration during the early resuscitation of bleeding trauma patients [79]. cache = ./cache/cord-017946-fa4ehlb0.txt txt = ./txt/cord-017946-fa4ehlb0.txt === reduce.pl bib === id = cord-018209-v2crgj5w author = Pastores, Stephen M. title = What Has Been Learned from Postmortem Studies? date = 2010-08-19 pages = extension = .txt mime = text/plain words = 5270 sentences = 327 flesch = 31 summary = Infectious and noninfectious pulmonary complications occur in 30-60% of patients with hematological malignancy and recipients of hematopoietic stem cell transplantation (HSCT) and are associated with signifi cant morbidity and mortality [1] . This chapter will review the infectious and noninfectious pulmonary findings that have been described at autopsy in patients with hematological malignancies, including blood and bone marrow transplant recipients. Table 20 .1 lists the infectious and non-infectious pulmonary disorders reported in autopsy studies of patients with hematologic malignancy, including HSCT recipients. Several autopsy series have reported diagnostic discrepancies between premortem clinical diagnosis and postmortem autopsy findings ranging from 5% to 64% in patients with hematologic malignancy and HSCT recipients (Table 20. Infectious and noninfectious pulmonary diseases are commonly found on postmortem autopsy studies in patients with hematological malignancy and HSCT recipients. Major diagnostic discrepancies between clinical premortem diagnoses and postmortem autopsy findings have been reported in patients with hematologic malignancy. cache = ./cache/cord-018209-v2crgj5w.txt txt = ./txt/cord-018209-v2crgj5w.txt === reduce.pl bib === id = cord-017799-2nvrakbs author = Patel, Zara M. title = Acute Bacterial Rhinosinusitis date = 2018-05-04 pages = extension = .txt mime = text/plain words = 4391 sentences = 220 flesch = 41 summary = Acute bacterial rhinosinusitis most commonly occurs as a complication of viral infection, complicating 0.5-2.0% of cases of the common cold [10] , However, other factors may also predispose to ABRS, such as allergy, immune dysfunction, impaired ciliary function, anatomic narrowing of the sinuses, or poor dentition [11] . Only for suspected complication involving orbit or central nervous system Similar recommendations for adults Initial therapy of ABRS Antibiotics for worsening course or severe onset ("2" or "3" above), but antibiotics or watchful waiting (for up to 3 days) for "persistent illness" ("1" above) cache = ./cache/cord-017799-2nvrakbs.txt txt = ./txt/cord-017799-2nvrakbs.txt === reduce.pl bib === id = cord-018110-mcw4v13c author = Arnold, Andreas title = Inner Ear date = 2010 pages = extension = .txt mime = text/plain words = 15854 sentences = 980 flesch = 46 summary = In the case of partial or no remission, prednisolone treatment should be continued orally for 16 days together with gastric proton pump inhibitors and additional haemodilutive/haemorheological infusion therapy together with α-lipoic acid should be administered as described for high-frequency idiopathic sensorineural hearing loss. Acute tinnitus due to noise-induced damage or acoustic trauma of the inner ear, idiopathic sensorineural hearing loss (sudden deafness), acute attack of Ménière's disease, toxic labyrinthitis, rupture of the round window, perilymphatic fistula of the round or oval window, labyrinthine contusion or fractures of the temporal bone due to head trauma should be treated with a daily dose of 250-500 mg prednisolone intravenously on three consecutive days. cache = ./cache/cord-018110-mcw4v13c.txt txt = ./txt/cord-018110-mcw4v13c.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-018363-qr1pk78u author = Casey, Ashley title = Consultative and Comanagement date = 2015-10-10 pages = extension = .txt mime = text/plain words = 19168 sentences = 1810 flesch = 60 summary = Results of physical examination are as follows: temperature, 38.9 °C (102.1 °F); heart rate, 116 bpm; blood pressure, 96/60 mmHg; respiratory rate, 35 breaths/min; and O 2 saturation, 74 % on 100 % O 2 with a nonrebreather mask. In the past 20 min, the patient has become abruptly short of breath, hypoxic, and severely hypotensive with a blood pressure of 72/palpation mm Hg. On physical exam, she is obtunded and in serve respiratory distress. A 64-year-old female with a past medical history signifi cant for type 2 diabetes mellitus is admitted with increasing shortness of breath. A meta-analysis of 15 studies reports that hyperglycemia increased both in-hospital mortality and incidence of heart failure in patients admitted for acute myocardial infarction. Continuing warfarin treatment at the time of pacemaker in patients with high thrombotic risk was associated with a lower incidence of clinically signifi cant device-pocket hematoma, as opposed to bridging with heparin. cache = ./cache/cord-018363-qr1pk78u.txt txt = ./txt/cord-018363-qr1pk78u.txt === reduce.pl bib === === reduce.pl bib === id = cord-014794-yppi30a0 author = nan title = 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date = 2003-07-31 pages = extension = .txt mime = text/plain words = 158059 sentences = 9041 flesch = 44 summary = These parts were in a high percentage associated with fibrosis and lymphocyte rich areas and showed a higher mitotic activity than usual PTCs. Discussion The differences in the occurrence of TCV and TCmorphology between the presented series and previously reported cases might result from until now not clearly defined tall cell morphology as well as from similarities to PTCs, such as the oxyphilic variant, which is extremely rare in our series, and maybe also from often described squamous changes within PTCs. Due to these data it is not clear which tumor parts have relevance for prognosis and which tumors should be treated more aggressively than others. The aims of this study were to characterize the group of patients with BSOT and evaluate the significance of various molecular markers expression versus serous papillary ovarian carcinomas (SPOC) Material and methods We analyzed a total of 102 cases including: 64 cystadenoma, 10 borderline and 28 cystadenocarcinoma. cache = ./cache/cord-014794-yppi30a0.txt txt = ./txt/cord-014794-yppi30a0.txt === reduce.pl bib === === reduce.pl bib === id = cord-018303-dvuwhpyq author = Garibaldi, Brian T. title = Aeromedical Evacuation of Patients with Contagious Infections date = 2019-02-27 pages = extension = .txt mime = text/plain words = 9008 sentences = 454 flesch = 47 summary = Topics include a review of the ecology of aircraft cabins and engineering features of aircraft ventilation systems that minimize the risk of disease transmission; examples of point source outbreaks related to air travel; in-flight preventive measures including the use of patient isolators; and US military and international policy and legal aspects of transporting patients with communicable diseases. Examples include in-flight transmission of tuberculosis, severe acute respiratory syndrome (SARS), smallpox, and measles.The chapter will also discuss experience in transporting patients with contagious diseases including viral hemorrhagic fevers and new patient isolation technologies that were used for the long-distance transport of patients with Ebola virus disease during the 2014–2016 West African epidemic. In response to concerns generated by lethal viral hemorrhagic fevers, and a possible need to transport patients with these diseases by air, the ventilation and air-conditioning systems on pressurized, long-range transport aircraft were studied to evaluate the aerodynamics of aerosolized microorganisms [19] . cache = ./cache/cord-018303-dvuwhpyq.txt txt = ./txt/cord-018303-dvuwhpyq.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-018545-fk17n2bx author = Dorofaeff, Tavey title = Infections in the PICU date = 2012 pages = extension = .txt mime = text/plain words = 14180 sentences = 981 flesch = 47 summary = Herpes Simplex Virus (HSV, types 1 and 2) (a) Systemic infection in the neonate with shock and coagulopathy and severe liver failure (b) Encephalitis, hepatitis (c) Local (mouth, esophagus, larynx, lungs, heart, liver, kidneys, CNS) or systemic disease in organ and stem cell transplant and immunocompromised patients 2. Pneumonia means inflammation of the lung parenchyma caused by infection and the diagnosis is made clinically in a febrile child with respiratory signs and symptoms who has evidence of consolidation on CXR. • Development of an empyema or less commonly a lung abscess • Underlying lung disease such as: bronchopulmonary dysplasia (BPD, in ex-premies), cystic fibrosis, inhaled foreign body, tracheobronchomalacia or post tracheal surgery, or infected congenital lung cyst • Diagnosed or undiagnosed immunodeficiency states (primary, HIV, leukemia) • Children with neuromuscular diseases, weakness, or spasticity such as muscular dystrophies, myasthenia, spinal muscular atrophy, or cerebral palsy • Inappropriate antibiotics, inappropriately low dose or resistant bacteria • Non bacterial pneumonia (viral pneumonia or alternative pathogen such as Tuberculosis) cache = ./cache/cord-018545-fk17n2bx.txt txt = ./txt/cord-018545-fk17n2bx.txt === reduce.pl bib === === reduce.pl bib === id = cord-018412-kv3vxmcw author = Bambi, Stefano title = Evolution of Intensive Care Unit Nursing date = 2017-10-06 pages = extension = .txt mime = text/plain words = 8546 sentences = 428 flesch = 43 summary = In future, increases in the number of ICU beds relative to bed numbers in other hospital wards will probably be contemplated, even in a scenario of decreasing costs; clinical protocols will be computerized and/or nurse-driven; more multicenter and international trials will be performed; and organizational strategies will concentrate ICU personnel in a few large units, to promote the flexible management of these healthcare workers. Moreover, extracorporeal organ support technologies will be improved; technology informatics will cover all the bureaucratic aspects of healthcare work, aiding the staff in workload assessment; and critical care multidisciplinary rounds and follow-up services for post-ICU patients will be implemented. • Development of methods for fast recognition of acute patients at high risk of rapid deterioration • Minimally invasive organ support technologies • New approaches to enhance patient comfort while reducing changes of consciousness • Effective process and outcome measurements for critical illness research and palliative and EOL care. cache = ./cache/cord-018412-kv3vxmcw.txt txt = ./txt/cord-018412-kv3vxmcw.txt === reduce.pl bib === id = cord-018225-dozmy3lb author = Hawker, Felicity H. title = The liver in critical illness date = 2008 pages = extension = .txt mime = text/plain words = 6814 sentences = 319 flesch = 45 summary = The paper by Harrison and co-workers, again from the King's Liver Unit, investigates the effects of n-acetylcysteine in patients with acute liver failure, and the findings of this study have resulted in widespread use of this agent in this setting. The incidence of hypoxic hepatitis was prospectively studied for 1 year in a group of high-risk patients suffering from low cardiac output in a coronary care unit. In intensive care patients, a rapid decrease in MEGX test values is associated with increased risk of developing multiple organ failure, and a poor outcome, and consequently may have a role in investigation of the role of the liver in the multiple organ failure syndrome. We studied the effect of acetylcysteine on systemic hemodynamics and oxygen transport in 12 patients with acetaminophen-induced fulminant hepatic failure, and 8 patients with acute liver failure from other causes. The increase in oxygen delivery and consumption in response to acetylcysteine may account for its beneficial effect on survival in patients with fulminant hepatic failure induced by acetaminophen. cache = ./cache/cord-018225-dozmy3lb.txt txt = ./txt/cord-018225-dozmy3lb.txt === reduce.pl bib === id = cord-018447-z4jyjczy author = D’Cruz, David P. title = Antiphospholipid (Hughes) Syndrome: An Overview date = 2006 pages = extension = .txt mime = text/plain words = 5167 sentences = 269 flesch = 45 summary = The Antiphospholipid Antibodies in Stroke Study (APASS) Group also found a prevalence of aCL in 4.3% of 257 hospitalized non-stroke patients with a mean age 66 [16] . In a meta-analysis, Wahl examined the risk of venous thromboembolism in aPL-positive patients without autoimmune disease or previous thrombosis. The largest prospective study of 1000 SLE patients showed that after 10 years of follow up there were 68 deaths of whom 18 (26.5%) died from thrombosis associated with aPL [7] . However, studies in patients without lupus who are aPL positive have shown increased carotid intima-media thickness associated with an increased risk of arterial thrombosis [38] . In general, there are no significant differences in the cardinal clinical features of APS, such as arterial or venous thrombosis or pregnancy morbidity, whether the syndrome is primary or secondary to an underlying connective tissue disorder [33, 50] . cache = ./cache/cord-018447-z4jyjczy.txt txt = ./txt/cord-018447-z4jyjczy.txt === reduce.pl bib === id = cord-018454-sy21cpff author = Mitrovic, Stéphane title = Adult-Onset Still’s Disease date = 2019-10-30 pages = extension = .txt mime = text/plain words = 9387 sentences = 495 flesch = 41 summary = (continued) Identifying the disease subset might orientate the therapeutic strategy c Serum ferritin levels are significantly higher in the systemic subtype [110] , but high ferritin levels after adequate treatment may predict chronic articular course [61] d Calprotectin levels help rule out rheumatoid arthritis, but further studies are needed to validate it as a diagnostic biomarker because of no statistical difference between AoSD and septic patients, although the populations were small [42] e Elevated plasma levels of IL-1β, IL-6, and TNFα have been found during AoSD, but the cytokine profile is not specific and cannot differentiate AoSD patients from those with sepsis f S100A12 was found an efficient diagnostic and monitoring biomarker in systemic juvenile arthritis, but further studies are needed for validation in AoSD Procalcitonin, a marker of severe systemic infection, was also found elevated in patients with active AoSD and does not appear relevant to distinguish acute infection from AoSD flare [42, 113] . cache = ./cache/cord-018454-sy21cpff.txt txt = ./txt/cord-018454-sy21cpff.txt === reduce.pl bib === id = cord-018430-u3k8pds6 author = Mason, Jay W. title = Myocarditis date = 2007 pages = extension = .txt mime = text/plain words = 21734 sentences = 1351 flesch = 34 summary = The classification states that "myocarditis is diagnosed by established histological, immunological and immunohistochemical criteria." The Dallas criteria 5 provide consensus-derived histologic criteria: "an inflammatory infiltrate of the myocardium with necrosis and/or degeneration of adjacent myocytes not typical of ischemic damage associated with coronary artery disease." However, many have speculated that less pronounced histologic abnormalities may be present and that additional molecular, immunologic, and immunohistochemical diagnostic criteria can be used productively. 330 These criteria define active myocarditis (see also Fig. 59 .7A) as "an inflammatory infiltrate of the myocardium with necrosis and/or degeneration of adjacent myocytes not typical of ischemic damage associated with coronary artery disease." Furthermore, other causes of inflammation (e.g., connective tissue disorders, infection, drugs) should be excluded. 392 An interesting hypothesis to explain the high frequency of dilated heart muscle disease is the presence of myocarditis in HIV-infected patients with left ventricular dysfunction. The ECG abnormalities suggesting myocardial involvement are present in a high proportion of patients, 414 but clinical evidence of cardiac dysfunction occurs in only 10% to 25% of cases. cache = ./cache/cord-018430-u3k8pds6.txt txt = ./txt/cord-018430-u3k8pds6.txt === reduce.pl bib === id = cord-018620-3kqx8arn author = Rueda, Mario title = Hepatic Failure date = 2016-10-09 pages = extension = .txt mime = text/plain words = 13808 sentences = 842 flesch = 44 summary = In this chapter we will discuss the definition, clinical manifestations, workup, and management of acute and chronic liver failure and the general principles of treatment of these patients. Other mechanisms that may explain this symptom include the endogenous opioids theory which proposes that the liver failure patient has elevated opioid levels secondary to decrease clearance and metabolism. Past medical history plays a key role in determining if the patient has chronic liver disease or if they are experiencing an acute failure. A decrease in glutathione levels, enhanced cytochrome P450 activity secondary to medication use, acetaminophen overdose, or decreased liver function from chronic disease make patients more susceptible to developing toxicity. Patients with hepatitis secondary to shock present with several symptoms related to their hemodynamic instability including altered mental status, respiratory distress, severe hypotension, and renal failure. cache = ./cache/cord-018620-3kqx8arn.txt txt = ./txt/cord-018620-3kqx8arn.txt === reduce.pl bib === id = cord-018623-of9vx7og author = Saghazadeh, Amene title = The Physical Burden of Immunoperception date = 2019-04-27 pages = extension = .txt mime = text/plain words = 5755 sentences = 262 flesch = 37 summary = Further, human studies provided evidence pointing to the increased development of emotional problems and EDR-related disorders in patients with various types of AIDs, such as SLE and multiple sclerosis (MS), in a disease state/severity-dependent manner [12] [13] [14] [15] [16] [17] . Thus, it is not surprising that the inflammatory response and respective cytokines are supposed as one of the possible mechanisms linking the experience of negative emotions or ER-related disorders and the progression of cardiovascular diseases, of course along with the neuroendocrine system and apoptosis signaling pathways [27, 30, [32] [33] [34] [35] . Mice subjected to short-term (1-3 weeks) HFD also exhibited anxiety-like behaviors in addition to learning and memory impairments and had significantly higher levels of homovanillic acid-a metabolite of dopamine-in their hippocampus and cortex but without any alteration in the gene expression of inflammatory markers [89] . Increased emotional distress in daughters of breast cancer patients is associated with decreased natural cytotoxic activity, elevated levels of stress hormones and decreased secretion of Th1 cytokines cache = ./cache/cord-018623-of9vx7og.txt txt = ./txt/cord-018623-of9vx7og.txt === reduce.pl bib === id = cord-018601-mk66097y author = Michelakis, Evangelos D. title = Pulmonary Arterial Hypertension date = 2007 pages = extension = .txt mime = text/plain words = 26230 sentences = 1416 flesch = 44 summary = 18 Primary PHT was defined as mean pulmonary artery (PA) pressure >25 mm Hg at rest (or >30 mm Hg with exercise) in the absence of secondary causes for PHT, a definition different from the current definition of PAH, which includes PHT due to more common diseases like collagen vascular disease, HIV infection, portal hypertension, congenital heart disease as PAH (Table 105 .2). The following tests should be obtained in all patients in whom the cause of PHT is not evident: electrocardiogram (ECG), chest radiograph, arterial blood gases, complete blood count, electrolytes and liver function tests, pulmonary function tests (PFTs), ventilation/ perfusion lung scan, serology for rheumatic diseases (e.g., fluorescent antinuclear antibody, FANA), serology for HIV, ventilation perfusion (V/Q) scan, and an echocardiogram with Doppler assessment of PA acceleration time and tricuspid regurgitation velocity as well as an echo-contrast study, to exclude shunting. cache = ./cache/cord-018601-mk66097y.txt txt = ./txt/cord-018601-mk66097y.txt === reduce.pl bib === id = cord-018595-x3tleomb author = Dodiuk-Gad, Roni P. title = Adverse Medication Reactions date = 2017-04-25 pages = extension = .txt mime = text/plain words = 16304 sentences = 910 flesch = 39 summary = 2. Delayed-type drug hypersensitivity: Delayed-type drug hypersensitivity reactions usually take several days to weeks following drug exposure, with variable clinical presentations that may include Maculopapular Eruption (MPE), Fixed Drug Eruption (FDE), Acute Generalized Exanthematous Pustulosis (AGEP), Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Examples of strong associations of HLA alleles with specific drug-induced hypersensitivity reactions include abacavir, nevirapine, carbamazepine, and allopurinol (Table 25. [61] , who reported the weak associations of HLA-A29, B12, and MPE maculopapular drug eruption, DRESS drug reaction with eosinophilia and systemic symptoms, SJS/TEN Stevens-Johnson syndrome/toxic epidermal necrolysis DR7 in sulfonamide-related TEN, and HLA-A2, B12 in oxicam-related TEN in Europeans [61] . Drug specific cytotoxic T-cells in the skin lesions of a patient with toxic epidermal necrolysis cache = ./cache/cord-018595-x3tleomb.txt txt = ./txt/cord-018595-x3tleomb.txt === reduce.pl bib === id = cord-018801-amet0wx4 author = Park, Caroline title = Care of the Patient with Liver Failure Requiring Transplantation date = 2018-05-04 pages = extension = .txt mime = text/plain words = 4703 sentences = 237 flesch = 30 summary = Depending on acuity, patients with decompensated chronic or acute fulminant liver failure generally require preoperative intensive care unit admission to manage organ dysfunction. Depending on acuity, patients with decompensated chronic or acute fulminant liver failure generally require preoperative intensive care unit (ICU) admission to manage organ dysfunction. In patients that develop AKI post-liver transplantation, treatment includes the prevention of hypotension and decreased use of unnecessary blood products. Early postoperative infections in liver transplant patients are typically bacterial and related to the donor's status (previous infections from advanced cirrhosis), the surgical procedure itself, prolonged use of invasive catheters, and duration of mechanical ventilation. The resulting lack of blood flow and developing ischemia and necrosis from hepatic artery thrombosis present with signs and symptoms similar to fulminant liver failure patients with elevated liver serum tests, coagulopathy, and severe metabolic acidosis. cache = ./cache/cord-018801-amet0wx4.txt txt = ./txt/cord-018801-amet0wx4.txt === reduce.pl bib === id = cord-018638-4pyjhpbk author = Pilania, Rakesh Kumar title = Kawasaki Disease date = 2019-10-30 pages = extension = .txt mime = text/plain words = 5674 sentences = 378 flesch = 50 summary = Acute non-purulent cervical lymphadenopathy Table 4 .2 AHA 2017 diagnostic criteria for KD [28] Diagnosis of classic KD can be proffered in the presence of fever for at least 5 days associated with at least 4 of the 5 following principal clinical features. Cervical lymphadenopathy (>1.5 cm diameter), usually unilateral A careful history may reveal that ≥1 principal clinical features were present during the illness but resolved by the time of presentation Exclusion of other diseases with similar findings (e.g., scarlet fever, viral infections like measles, adenovirus, enterovirus, Stevens-Johnson syndrome, toxic shock syndrome, drug hypersensitivity reactions, systemic juvenile idiopathic arthritis) unusual for KD. Perianal desquamation is virtually pathognomonic of KD and is a useful clinical sign for diagnosis of the disease during the acute phase ( Fig. 4 .3c). Epidemiological and clinical characteristics of Kawasaki disease and factors associated with coronary artery abnormalities in East China: nine years experience cache = ./cache/cord-018638-4pyjhpbk.txt txt = ./txt/cord-018638-4pyjhpbk.txt === reduce.pl bib === id = cord-018714-i291z2ju author = Criado, Paulo Ricardo title = Adverse Drug Reactions date = 2016-12-31 pages = extension = .txt mime = text/plain words = 23904 sentences = 1177 flesch = 38 summary = • If possible identify the physiopathologic mechanism involved in the reaction; • Identify as rapidly as possible the drug inducing the reaction and always opt for its withdrawal; in some circumstances the choice is difficult as there is no alternative drug and its use is essential for the maintenance of life; • A careful and intensive observation is recommended for the occurrence of warning signs regarding the appearance of a potentially severe adverse drug reaction, especially in relation to mucous, oral, ocular, and genital involvement and progression of any present cutaneous eruption; • It is imperative that the drug responsible may be withdrawn on a permanent basis together with chemically related com-pounds, and this advice is also valid for first-degree relatives who can present the same type of reaction. cache = ./cache/cord-018714-i291z2ju.txt txt = ./txt/cord-018714-i291z2ju.txt === reduce.pl bib === id = cord-018907-c84t1bo5 author = Bin-Hussain, Ibrahim title = Infections in the Immunocompromised Host date = 2012 pages = extension = .txt mime = text/plain words = 3646 sentences = 170 flesch = 29 summary = In providing empirical antibiotic therapy in patient with pulmonary infiltrate and defect in cell-mediated immunity one need to consider Pneumocystis jiroveci, nocardia, legionella, mycoplasma, in addition to aerobic Gram-positive cocci and Gram-negative bacilli therefore it is advised to use trimethoprim-sulfamethoxazole, macrolides including erythromycin or clarithromycin and agent active against Gram-positive and Gram-negative; for example, thirdgeneration cephalosporin with or without aminoglycoside with anti-Gram-positive either nafcillin or vancomycin based on the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and penicillin resistant Streptococcus pneumoniae. The factors influencing antimicrobial selection include the types of bacterial isolates found in the institution, antibiotic susceptibility patterns, drug allergies, presence of organ dysfunction, chemotherapeutic regimen whether the patient was receiving prophylactic antibiotics, and condition of the patient at diagnosis, for example, presence of signs and symptoms at initial evaluation and presence of documented sites requiring additional therapy. cache = ./cache/cord-018907-c84t1bo5.txt txt = ./txt/cord-018907-c84t1bo5.txt === reduce.pl bib === id = cord-018809-3nrvm4jt author = McMullin, N. R. title = Hemostatic Resuscitation date = 2006 pages = extension = .txt mime = text/plain words = 6231 sentences = 294 flesch = 46 summary = In combat, fresh whole blood for massive transfusion becomes a blood bank multiplier, providing within a single unit, RBCs, volume, coagulation components, and functional platelets in a warm fluid. Appropriate use following established guidelines can be beneficial and may even be superior to packed RBCs. A fluid containing the vital properties of fresh whole blood would serve as a bridge to allow a patient to be resuscitated without initiating the'bloody cycle of death' that is seen all too often in our current paradigm of massive resuscitation. Appropriate use following established guidelines can be beneficial and may even be superior to packed RBCs. A fluid containing the vital properties of fresh whole blood would serve as a bridge to allow a patient to be resuscitated without initiating the'bloody cycle of death' that is seen all too often in our current paradigm of massive resuscitation. cache = ./cache/cord-018809-3nrvm4jt.txt txt = ./txt/cord-018809-3nrvm4jt.txt === reduce.pl bib === id = cord-018834-4ligp4ak author = Farag, Ehab title = The Perioperative Use of Albumin date = 2016-06-23 pages = extension = .txt mime = text/plain words = 7554 sentences = 379 flesch = 43 summary = HSA is the most important antioxidant capacity of human plasma, in addition to its ability to protect the body from the harmful effects of heavy metals such as iron and copper and reduce their ability to produce reactive oxygen radicals. Recently, its use has been questioned following a widely publicized meta-analysis in 1998 that reported increased mortality in patients who received albumin solutions; the role of albumin administration in critically ill patients became highly controversial. However, the results of this meta-analysis have been challenged by several metaanalyses, randomized controlled trials that not only proved the safety of HSA but its benefi t especially in patients with sepsis, liver failure, hypoalbuminemia, and burns [ 1 -4 ] . HSA administration favorably infl uences plasma thiol-dependent antioxidant status, as well as levels of protein oxidative damage in patients with sepsis and acute respiratory distress syndrome (ARDS) [ 21 , 22 ] . cache = ./cache/cord-018834-4ligp4ak.txt txt = ./txt/cord-018834-4ligp4ak.txt === reduce.pl bib === id = cord-018780-zeok60hn author = Biddinger, Paul D. title = Evaluation of the Person Under Investigation date = 2018-07-07 pages = extension = .txt mime = text/plain words = 5764 sentences = 212 flesch = 42 summary = A patient presenting to healthcare facilities with specific clinical and epidemiological risk factors for infection with one of these pathogens may be termed a person under investigation (PUI) for the disease, and healthcare staff should utilize carefully developed protocols and procedures to guide their subsequent isolation and clinical evaluation practices until the disease has been ruled in or out. After the patient has been safely isolated, senior clinic staff must be notified and must contact appropriate subject matter experts for direction on next steps including (1) whether (based on information already available) the patient meets PUI criteria or if additional information is required; (2) if the latter, direction on the safe use of PPE and distancing from the patient; (3) advice on what types of care can safely be provided in that setting for patients confirmed as PUIs; and (4) instructions on transferring the patient to another more appropriate location for further clinical evaluation and management if deemed necessary. cache = ./cache/cord-018780-zeok60hn.txt txt = ./txt/cord-018780-zeok60hn.txt === reduce.pl bib === id = cord-019046-q6uv2ayi author = Hughes, Amy L. title = Laryngeal Infections date = 2015-07-14 pages = extension = .txt mime = text/plain words = 3588 sentences = 202 flesch = 44 summary = The chapter reviews the diagnostic approach to laryngeal infections, focusing on key points of the history and physical exam, including concerning signs and symptoms suggestive of airway distress. Viral and bacterial laryngitis, croup, epiglottis, recurrent respiratory papillomatosis, as well as some less common causes of bacterial infections are discussed in detail with each etiology's epidemiology, clinical features, associated diagnostic evaluation, and management reviewed. The assessment of a patient with a suspected laryngeal infection should include a prompt evaluation for airway compromise focusing on stridor, increased work of breathing with retractions and accessory muscle use, and cyanosis. In the most severe cases of croup, patients may require direct laryngoscopy, bronchoscopy and intubation, although this is typically avoided as the endotracheal tube can contribute to the development of subglottic stenosis. There are several additional, however, less common causes of laryngeal infection that may present with airway symptoms. cache = ./cache/cord-019046-q6uv2ayi.txt txt = ./txt/cord-019046-q6uv2ayi.txt === reduce.pl bib === id = cord-019010-9xgwjvsv author = Luna, C. M. title = Life-threatening Respiratory Failure from H1N1 Influenza: Lessons from the Southern Cone Outbreak date = 2010-06-23 pages = extension = .txt mime = text/plain words = 4578 sentences = 192 flesch = 35 summary = Consistent with this particular situation, the health system in the metropolitan area of Buenos Aires began to show evidences of collapse, use of ventilators increased critically, achieving an extremely unusual level; about a quarter of the available ICU beds were occupied by young and previously healthy patients with ARDS associated with severe bilateral pneumonia due to 'swine flu' who needed mechanical ventilation. These figures are difficult to extrapolate globally and to confirm, as epidemiological studies looking at the population at risk in different world areas are lacking, but the huge number of severely ill patients with ARDS due to primary influenza pneumonia (an extremely unusual complication) observed in the Southern Cone, suggest that these estimations could be realistic. Viral cultures of respiratory specimens, especially if A 29 year-old obese male with arterial hypertension secondary to Cushing's disease (hypophyseal adenoma) developed bilateral pneumonia and died from respiratory failure secondary to acute respiratory distress syndrome (ARDS) after 13 days on mechanical ventilation, with multiple organ failure, including renal and hemodynamic compromise requiring high doses of vasopressors. cache = ./cache/cord-019010-9xgwjvsv.txt txt = ./txt/cord-019010-9xgwjvsv.txt === reduce.pl bib === === reduce.pl bib === id = cord-015021-pol2qm74 author = nan title = Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date = 1994 pages = extension = .txt mime = text/plain words = 162327 sentences = 9379 flesch = 50 summary = It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. cache = ./cache/cord-015021-pol2qm74.txt txt = ./txt/cord-015021-pol2qm74.txt === reduce.pl bib === id = cord-019043-cqmqwl3i author = Fidalgo, Pedro title = Chronic Kidney Disease in the Intensive Care Unit date = 2014-03-08 pages = extension = .txt mime = text/plain words = 8675 sentences = 409 flesch = 32 summary = The incidence and prevalence of chronic kidney disease (CKD) and end-stage renal disease are increasing, and these patients have a higher risk of developing critical illness and being admitted to the intensive care unit (ICU) compared to the general population. Factors that have been shown to be associated with ICU mortality in ESRD patients are older age, higher illness severity score (i.e., APACHE II or SAPS II), burden of nonrenal organ dysfunction/failure, medical or nonsurgical admission type, and provision and duration of life-sustaining technologies (i.e., mechanical ventilation, vasopressor therapy). Synthetic colloids, such as hydroxyethyl starch (HES), have appeal for resuscitation fluids based on the premise that they attenuate the inflammatory response, mitigate endothelial barrier dysfunction, improve microcirculatory flow, and contribute to more rapid hemodynamic stabilization; however, accumulated data have now suggested use of these fluids in critical illness is associated with dosedependent risk for severe AKI requiring RRT, bleeding complications, and death (Box 32.2). cache = ./cache/cord-019043-cqmqwl3i.txt txt = ./txt/cord-019043-cqmqwl3i.txt === reduce.pl bib === id = cord-019968-o5bdb37q author = Goldwater, Paul N. title = Gastroenteritis in Auckland: An aetiological and clinical study date = 2005-04-14 pages = extension = .txt mime = text/plain words = 3584 sentences = 214 flesch = 51 summary = Faecal specimens from 60 patients (under six years old), most of whom were Maoris and Pacific Islanders admitted to Auckland Hospital with gastroenteritis during the months of June and July 1977, were examined for the presence of faecal viruses, bacterial pathogens and parasites. Non-agglutinable rotavirus, presumably a different serotype, was seen in both gastroenteritis and control patients. In June and July, 1977 , patients admitted to Auckland Hospital with gastroenteritis were studied to determine the relative isolation rates of (1) rotavirus, (2) other viruses identifiable by electronmicroscopy of stools, (3) enterotoxigenic Esch. Three of 18 (17 per cent) control stools contained rotavirus (one of which had non-agglutinable virus detectable on IEM). From Table III it is seen that enterotoxigenic isolates were found in both groups of gastroenteritis patients and also in non-diarrhoeal controls. Rotavirus-like particles that failed to agglutinate on IEM were seen in two gastroenteritis patients' stools and in one control patient's stool. cache = ./cache/cord-019968-o5bdb37q.txt txt = ./txt/cord-019968-o5bdb37q.txt === reduce.pl bib === === reduce.pl bib === id = cord-021713-e0hzcag6 author = nan title = Ribavirin date = 2015-10-21 pages = extension = .txt mime = text/plain words = 10899 sentences = 501 flesch = 37 summary = A 38-year-old man developed ischemic optic neuropathy after taking ribavirin 800 mg/day þ peginterferon alfa for 6 months; his visual acuity and field defect failed to improve despite withdrawal of interferon and therapy with high dose systemic steroids [46] . Type 1 diabetes mellitus and thyroid disease reportedly develop in 0.08-2.6% and 10-15% of patients treated with combined interferon-alfa þ ribavirin for chronic hepatitis C, but rarely coexist; however, both conditions have been reported in a 33-year-old woman [65] . A 49-year-old man who took long-term ribavirin þ peginterferon alfa for chronic hepatitis C developed an autoimmune hemolytic anemia after 56 weeks of therapy and required transfusion and withdrawal of both agents [67] . In a randomized controlled trial of high-dose interferon alfa-2b plus oral ribavirin for 6 or 12 months in 50 patients with chronic hepatitis C, the sequential effects of treatment on hemoglobin, leukocytes, and platelets were recorded [78] . cache = ./cache/cord-021713-e0hzcag6.txt txt = ./txt/cord-021713-e0hzcag6.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-021075-8hba6au3 author = Ouallet, J.-C. title = Aspects cliniques, physiopathologiques, et thérapeutiques de la sclérose en plaques date = 2004-07-29 pages = extension = .txt mime = text/plain words = 25142 sentences = 2490 flesch = 70 summary = Les patients n'ayant eu qu'une poussée ne peuvent pas être classés dans une des quatre formes, alors qu'une majorité d'entre eux présente déjà probablement une SEP et que la répétition des IRM permet d'établir le diagnostic précocement en montrant l'apparition de nouvelles lésions (voir plus loin les critères diagnostiques). Ces critères stipulent que chez des patients ayant eu un premier épisode démyélinisant et réunissant les critères de Barkhof, l'apparition d'une lésion rehaussée par le gadolinium dans un territoire ne correspondant pas à la poussée initiale, sur une IRM réalisée au moins 3 mois après le début des troubles, est suffisante. De même, une méta-analyse des études longitudinales des formes rémittentes et secondairement progressives ayant utilisé le Gd a montré que le nombre de lésions Gd+ mesuré chaque mois pendant 6 mois était modestement prédictif du taux de poussées de l'année suivante mais pas de l'évolution du handicap dans les 12 à 24 mois suivants. cache = ./cache/cord-021075-8hba6au3.txt txt = ./txt/cord-021075-8hba6au3.txt === reduce.pl bib === id = cord-020342-u8jzmloq author = nan title = Index to volume 42, January–June 2003() date = 2003-11-20 pages = extension = .txt mime = text/plain words = 3793 sentences = 373 flesch = 58 summary = Impact on hospital resources of patients with severe congestive heart failure who use the emergency department for primary care Antiemetic therapy in US emergency departments: findings from the year 2000 National Hospital Ambulatory Medical Care Survey database Elevated blood lead levels associated with the consumption of moonshine among emergency department patients in Bioimpedance monitoring changes therapy in dyspneic emergency department patients: the IMPACT trial Use of ischemia-modified albumin in emergency department risk stratification of chest pain is both clinically effective and cost-effective Mathematical model of the hypoventilating patient: implications for the emergency department Clinical characteristics of emergency department patients who rule in versus rule out for pulmonary embolism by computed tomography chest angiography and indirect lower extremity computed tomography venography Role of air bags in preventing motor vehicle crash-related serious injuries: perceptions among emergency department patients Eight-hour emergency department observation for blunt abdominal trauma patients with initially negative diagnostic studies cache = ./cache/cord-020342-u8jzmloq.txt txt = ./txt/cord-020342-u8jzmloq.txt === reduce.pl bib === === reduce.pl bib === id = cord-022050-h24f0fpd author = Naughton, Matthew T. title = Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Asthma date = 2009-05-15 pages = extension = .txt mime = text/plain words = 6991 sentences = 345 flesch = 41 summary = • Hypercapnic chronic obstructive pulmonary disease (COPD) patients should be treated with noninvasive ventilation and supplemental oxygen sufficient to overcome hypoxemia but avoid hyperoxia. Uncontrolled oxygen administration may precipitate acute hypercapnia in patients with acute COPD exacerbations as a result of relaxing hypoxic vasoconstriction, thereby allowing increased perfusion to regions with reduced alveolar ventilation. Most commonly, patients with severe asthma have a history of previous hospitalizations for asthma (some that may be near fatal), low socioeconomic status, female gender, obesity, nighttime symptoms, FEV 1 less than 60% with optimal treatment, continual symptoms, reduced quality of life, use of oral or systemic steroids in the past 12 months, use of more than canister of SABA per month, elevated residual volume-tototal lung capacity (RV:TLC) ratio on pulmonary function testing, and a peak expiratory flow rate variability of more than 30% (i.e., variability-(bestworst)/best reading). Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. cache = ./cache/cord-022050-h24f0fpd.txt txt = ./txt/cord-022050-h24f0fpd.txt === reduce.pl bib === id = cord-021701-yan5q2r7 author = Woolard, Robert H. title = Emergency Department Design date = 2009-05-15 pages = extension = .txt mime = text/plain words = 4083 sentences = 272 flesch = 50 summary = In the aftermath of recent terror events and subsequent disaster planning, hospital architects have begun to design EDs to better meet the needs anticipated from a terror attack. The technology needed to respond to a terrorist event, such as personal protective equipment (PPE), is becoming more widely available and is stored where easily available in EDs. Although mass decontamination can occur close to the disaster scene, EDs are gearing up to decontaminate, isolate, and treat individuals or groups contaminated with biologic or chemical materials. [8] [9] [10] [11] [12] Sensor technology is an area of active research that continues to yield new solutions that are being incorporated into EDs. In concept, all entrances could be designed to identify persons using scanning to detect unwanted chemicals,biologic agents,or explosives and to detain and decontaminate as needed. Overflow patients in hallways and adjacent spaces can be managed with mobile computing, which is available in many EDs. Wireless handheld devices can facilitate preparation for disasters and allow immediate access to information by providers in hallways and decontamination spaces. cache = ./cache/cord-021701-yan5q2r7.txt txt = ./txt/cord-021701-yan5q2r7.txt === reduce.pl bib === id = cord-021917-z9wpjr0d author = Stephens, R. Scott title = Bioterrorism and the Intensive Care Unit date = 2009-05-15 pages = extension = .txt mime = text/plain words = 8255 sentences = 444 flesch = 44 summary = • Health care workers, accustomed to putting the welfare of patients ahead of their own in emergency situations, must be prepared for the proper use of personal protective equipment and trained in specific plans for the response to an infective or bioterrorism event. Although intensivists working in developed countries generally have little experience treating specific illnesses caused by serious bioweapon pathogens, these diseases result in clinical conditions that commonly require treatment in intensive care units (ICUs) (e.g., severe sepsis and septic shock, hypoxemic respiratory failure, and ventilatory failure). An optimal medical response to a bioweapon attack will require all or most of the following: early diagnosis, rapid case finding, large-scale distribution of countermeasures for postexposure prophylaxis or early treatment, immediate isolation of contagious victims, and enhanced capacity for providing medical care to seriously and critically ill victims. cache = ./cache/cord-021917-z9wpjr0d.txt txt = ./txt/cord-021917-z9wpjr0d.txt === reduce.pl bib === id = cord-021816-gk8rwyq4 author = Weinberger, Steven E. title = Pneumonia date = 2018-02-22 pages = extension = .txt mime = text/plain words = 7586 sentences = 365 flesch = 33 summary = In practice, several factors frequently cause enough impairment of host defenses to contribute to the development of pneumonia, even though individuals with such impairment are not considered "immunosuppressed." Viral upper respiratory tract infections, ethanol abuse, cigarette smoking, heart failure, and preexisting chronic obstructive pulmonary disease (COPD) are a few of the contributing factors. Three major settings in which this organism is seen as a cause of pneumonia are (1) as a secondary complication of respiratory tract infection with the influenza virus; (2) in the hospitalized patient, who often has some impairment of host defense mechanisms and whose oropharynx has been colonized by Staphylococcus; and (3) as a complication of widespread dissemination of staphylococcal organisms through the bloodstream. One issue that has sparked controversy is whether an attempt should be made to identify a specific etiologic agent, using Gram stain and culture, in patients with community-acquired pneumonia, or whether empirical therapy should be used based on the patient's risk factors, clinical characteristics, and local bacterial resistance patterns. cache = ./cache/cord-021816-gk8rwyq4.txt txt = ./txt/cord-021816-gk8rwyq4.txt === reduce.pl bib === id = cord-015359-gf32a6f1 author = nan title = B scientific sessions (SS) date = 2002 pages = extension = .txt mime = text/plain words = 159591 sentences = 9768 flesch = 51 summary = Methods and materials: 73 consecutive patients, clinically considered to have stage 1B tumour (confined to the cervix), underwent MR imaging studies at 1 T, according to the following protocol: fast spin-echo (FSE) T2-weighted, gadoliniumenhanced SE Tl-weighted, and fat-suppressed gadolinium-enhanced SE Tlweighted sequences. Purpose: To describe the radiological (thin section CT) findings correlated to activity and remission in ANCA associated pulmonary-renal small vessel vasculitis (SVV) Material and methods: We used retrospective analysis of 37 CTs, 27 in disease activity (8 first manifestations, 19 relapses) 10 im remission of 17 patients with pulmorenal syndrome (9 Wegener, 4 microscopic polyangiitis-MPA, 3 Churg-Strauss-syndrome, 1 idiopathic crescentic glomerulonephritis following the Chapel Hill classification) 7 women, 10 men, median 65.5 years (34 -84). Varghese, P.R. Mueller; Boston, MA/US Purpose: We sought to determine the incidence of malignancy and to assess a possible role for image guided biopsy of this category of renal masses Materials & methods: Of the 397 renal biopsies performed at our institution between 1991 and 2000; a total of 28 patients with 28 category III lesions, were identified for analysis. cache = ./cache/cord-015359-gf32a6f1.txt txt = ./txt/cord-015359-gf32a6f1.txt === reduce.pl bib === === reduce.pl bib === id = cord-022119-bzd9e1q6 author = Orzell, Susannah title = Pharyngitis and Pharyngeal Space Infections: fever, sore throat, difficulty swallowing date = 2018-10-15 pages = extension = .txt mime = text/plain words = 7308 sentences = 416 flesch = 44 summary = Deep neck space infections can also extend directly into the mediastinum or the lungs causing life-threatening mediastinitis or pneumonia, underscoring the importance of early recognition and treatment. The initial approach to a patient with suspected pharyngitis or parapharyngeal space infection, however, should always include a careful assessment for signs of airway compromise. Patients with persistent symptoms, who do not respond to empiric therapy based on the suspected diagnosis of infection, should undergo additional diagnostic testing to evaluate for the presence of the more unusual infectious and noninfectious entities. Deep neck space infections can present as discrete organized abscesses within specific neck spaces, as a soft tissue phlegmons without clearly forming collections of pus, or rarely, as a very rapidly destructive life-threatening process called necrotizing fasciitis. Complications of bacterial pharyngitis and deep neck space infections are uncommon, particularly if appropriate antibiotic therapy has been instituted and immediate surgical concerns have been addressed; however direct extension and invasion into surrounding structures or spaces are always a risk. cache = ./cache/cord-022119-bzd9e1q6.txt txt = ./txt/cord-022119-bzd9e1q6.txt === reduce.pl bib === id = cord-021571-7kbq0v9w author = Heath, Joan A. title = Infections Acquired in the Nursery: Epidemiology and Control date = 2009-05-19 pages = extension = .txt mime = text/plain words = 21244 sentences = 1014 flesch = 41 summary = The fact that a hand hygiene campaign was associated with increased hand hygiene compliance and a lower rate of CONS-positive cultures supports this ~ontention.'~ Enterococcus has been shown to account for 10% of total nosocomial infections in neonates, 6% to 15% of bloodstream infections, 0% to 5% of cases of pneumonia, 17% of urinary tract infections, and 9% of surgical site Sepsis and meningitis are common manifestations of enterococcal infection during NICU outbreak^'^,^^; however, polymicrobial bacteremia and NEC frequently accompany enterococcal sepsis.77 Identified risk factors for enterococcal sepsis, after adjustment for birth weight, include use of a nonumbilical CVC, prolonged presence of a CVC, and bowel resection?' Because Enterococcus colonizes the gastrointestinal tract and can survive for long periods of time on inanimate surfaces, the patient's environment may become contaminated and, along with the infant, serve as a reservoir for ongoing spread of the organism. cache = ./cache/cord-021571-7kbq0v9w.txt txt = ./txt/cord-021571-7kbq0v9w.txt === reduce.pl bib === id = cord-021905-fjcks7w4 author = Win, Patrick H. title = Asthma Triggers: What Really Matters? date = 2009-05-22 pages = extension = .txt mime = text/plain words = 5991 sentences = 297 flesch = 42 summary = The level of cat allergen that is required to induce asthma symptoms is not well defined, so strict avoidance and proper cleaning after an animal has been removed from the household are key to preventing morbidity. Accordingly, improper setting of the central air humidifier (commonly part of a home's central heating and air-conditioning unit) may worsen asthma control; while dehumidifiers set to keep humidity levels lower than 50% may be beneficial in reducing asthma symptoms from house-dust mite exposure. Similar to the aforementioned avoidance measures for pollen-sensitive asthmatic individuals, asthma symptoms from exposure to mold spores may be minimized by staying indoors as much as possible (especially during peak spore concentrations) and keeping home and automobile windows closed. Other important outdoor asthma triggers include exposure to vehicle traffic (especially diesel exhaust), which might exacerbate preexisting allergic conditions by enhancing airway responses to allergen, a potential compounding effect. cache = ./cache/cord-021905-fjcks7w4.txt txt = ./txt/cord-021905-fjcks7w4.txt === reduce.pl bib === id = cord-009997-oecpqf1j author = nan title = 2018 ASPHO ABSTRACTS date = 2018-03-31 pages = extension = .txt mime = text/plain words = 182060 sentences = 10342 flesch = 48 summary = Completed cranial radiation and proceeded to allogeneic stem cell transplant with unrelated cord marrow donor and is disease free at approximately day +200.Case 2: 5 year-old female diagnosed with FLT3 and MLL negative AML and completed treatment per COG AAML1031 study on the low risk arm without Bortezomib. Design/Method: This study was a retrospective chart review that included patients 3 to 23 years old with sickle cell disease type SS and S 0 followed at St. Christopher's Hospital for Children. Background: Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can reduce complications, and improve survival in sickle cell disease (SCD), but are associated with a significant decisional dilemma because of the inherent risk-benefit tradeoffs, and the lack of comparative studies. Brown University -Hasbro Children's Hospital, Providence, Rhode Island, United States Background: Despite clinical advances in the treatment of sickle cell disease (SCD) in pediatric and young adult patients, pain remains a significant source of disease-related morbidity. cache = ./cache/cord-009997-oecpqf1j.txt txt = ./txt/cord-009997-oecpqf1j.txt === reduce.pl bib === id = cord-022103-4zk8i6qb author = Siegel, Jane D. title = Pediatric Healthcare Epidemiology date = 2017-07-18 pages = extension = .txt mime = text/plain words = 12633 sentences = 562 flesch = 30 summary = A series of IPC guidelines have been developed and updated at varying intervals by the HICPAC/CDC, IDSA, Society for Healthcare Epidemiology of America (SHEA), American Academy of Pediatrics, Association for Professionals in Infection Control and Epidemiology, and others to provide evidence-based and rated recommendations for practices that are associated with reduced rates of HAIs, especially those infections associated with the use of medical devices and surgical procedures. (2) clinical microbiology laboratory services needed to support infection control outbreak investigations, including ability to perform molecular diagnostic testing; (3) data-mining programs and information technology specialists; (4) multidisciplinary programs to ensure judicious use of antimicrobial agents and control of resistance; (5) development of effective educational information for delivery to HCP, patients, families, and visitors; and (6) local and state health department resources for preparedness. cache = ./cache/cord-022103-4zk8i6qb.txt txt = ./txt/cord-022103-4zk8i6qb.txt === reduce.pl bib === id = cord-022646-f7qs1obg author = Frey, Noelle V. title = Hematopoietic stem cell transplantation: ASBMT/CIBMTR 2010 tandem meeting highlights and discussion date = 2010-04-27 pages = extension = .txt mime = text/plain words = 21917 sentences = 1117 flesch = 51 summary = The authors in this study report the incidence and risk factors associated with the development of solid tumors in 4349 pediatric and adult patients who underwent allogeneic stem cell transplant (SCT) for acute myelogenous leukemia (AML) in CR1 or chronic myelogenous leukemia (CML) in first chronic phase. The lower hOCT1 mRNA expression level in LEU from IMA naïve de novo CML patients compared to healthy volunteers as well as its progressive increase after the start of IMA therapy could be explained by the initial presence and subsequent gradual disappearance of tumor cells from the measured cell population. To confirm this hypothesis, we performed an analysis on the relationship of hOCT1 expression with the percentage of immature myeloid cells in the LEU samples (as a marker of disease burden) obtained from IMA naïve de novo CML patients. cache = ./cache/cord-022646-f7qs1obg.txt txt = ./txt/cord-022646-f7qs1obg.txt === reduce.pl bib === id = cord-022521-r72jtoso author = Miller, Tracie L. title = Gastrointestinal Complications of Secondary Immunodeficiency Syndromes date = 2010-12-27 pages = extension = .txt mime = text/plain words = 13694 sentences = 812 flesch = 36 summary = However, in the United States and other developed countries, severe malnutrition and new cases of perinatal HIV-1 disease are rare because of relatively high standards of living and effective highly active antiretroviral therapies (HAART) given to pregnant HIV-infected women that prevent transmission of HIV to the infants. Examination of both acute simian immunodeficiency virus (SIV) and HIV infection have documented reduced CD4 cell levels in GALT prior to a detectable reduction in T cells of the peripheral blood, highlighting the gastrointestinal tract's role and susceptibility. Previous studies have shown that activated mucosal T cells play a role in the pathogenesis of enteropathy in the human small intestine 37 and can affect the morphology of the villi and crypts in a manner similar to that seen in patients with HIV-1 infection. Immune restoration disease after the treatment of immunodeficient HIV-infected patients with highly active antiretroviral therapy cache = ./cache/cord-022521-r72jtoso.txt txt = ./txt/cord-022521-r72jtoso.txt === reduce.pl bib === id = cord-022173-kb6mez61 author = Calvillo Batllés, P. title = Hematologic neoplasms: Interpreting lung findings in chest computed tomography() date = 2015-11-06 pages = extension = .txt mime = text/plain words = 5374 sentences = 293 flesch = 37 summary = Chest HRCT plays a fundamental role---urgent when there are clinical signs of severity and early (<24 h) in the absence of a response to antibiotics therapy in 72---96 h because treatment of a possible invasive fungal infection (IFI) requires an early administration, a determinant factor for prognosis. 20, 40 Noninfectious complications secondary to treatment In the 6 h following the transfusion of blood products, the sudden appearance of consolidations simulating an edema and accompanying a respiratory failure usually reflect acute pulmonary damage (APD) called TRALI (transfusion-related alveolar lung injury) which associates high mortality rates. In patients with HP the thoracic HRCT helps us come close to the differential diagnosis of infectious and non-infectious pulmonary complications by integrating image findings and clinical data. cache = ./cache/cord-022173-kb6mez61.txt txt = ./txt/cord-022173-kb6mez61.txt === reduce.pl bib === id = cord-023169-obupqcua author = Chierakul, Wirongrong title = Leptospirosis date = 2013-10-21 pages = extension = .txt mime = text/plain words = 4982 sentences = 318 flesch = 41 summary = The severe illness, characterized by febrile illness with jaundice, acute renal injury and bleeding, is recognized as Weil's disease, though many different local names have been used such as Fort Bragg, mud, swamp and sugar cane fevers. Complications such as cholestatic jaundice, aseptic meningitis, acute renal injury, haemorrhage especially in the lung and myocarditis can occur and lead to a fatal outcome. 24 Complications such as jaundice, acute renal injury, haemorrhage, especially pulmonary haemorrhage, aseptic meningitis, myocarditis, shock, occur early during the course of illness. Acute pancreatitis has been reported rarely, although serum amylase may be raised in up to 60% of patients with severe disease due to renal impairment. Nowadays, the term 'Weil's syndrome' usually refers to the extremely severe form of leptospirosis, characterized by the combination of jaundice, renal dysfunction, and haemorrhagic diathesis, especially pulmonary haemorrhage. Acute febrile illness accompanied by jaundice and renal failure should always include leptospirosis in the differential diagnosis. cache = ./cache/cord-023169-obupqcua.txt txt = ./txt/cord-023169-obupqcua.txt === reduce.pl bib === id = cord-022658-mq91h15t author = nan title = Executive summary date = 2008-12-30 pages = extension = .txt mime = text/plain words = 12004 sentences = 656 flesch = 37 summary = Patients with rhinitis or asthma caused by allergens for which the clinical efficacy and safety of SIT have been documented by placebo-controlled, doubleblind studies, and those requiring daily pharmacotherapy for longer periods (e.g., preventive treatment during a pollen season or perennially) are candidates for SIT. in most cases when significant airway comorbidity is present (asthma, chronic sinusitis, nasal polyps, or otitis media with effusion) when the diagnosis is in question or special diagnostic testing is required when occupational rhinitis is suspected, to distinguish between clear-cut allergic reactions and toxic or nonallergic reactions when poor symptom control necessitates a consultation for environmental control measures, pharmacotherapy, or specific immunotherapy when medication side-effects are intolerable when rhinitis is only part of a complex series of mucosal allergies. cache = ./cache/cord-022658-mq91h15t.txt txt = ./txt/cord-022658-mq91h15t.txt === reduce.pl bib === id = cord-022216-k4pi30sd author = Kliegman, Robert M. title = Neonatal necrotizing enterocolitis date = 2009-05-15 pages = extension = .txt mime = text/plain words = 6110 sentences = 329 flesch = 32 summary = Neonatal necrotizing enterocolitis (NEC) is a disease of unknown origin that predominantly affects premature infants in level II, or more often level III, neonatal intensive care units during the infant's convalescence from the common cardiopulmonary disorders associated with prematurity. 1, 7 Indeed, NEC is the most common cause of gastrointestinal perforation (followed by isolated idiopathic focal intestinal perforation) and acquired short bowel syndrome among patients in the neonatal intensive care unit. 1, 12 Although NEC is noted predominantly in premature neonates, approximately 10% of cases occur in nearly full-term or full-term infants whose preceding risk factors have included polycythemia, cyanotic heart disease or heart disease producing low cardiac output (before or after surgery), chronic diarrhea, endocrine disorders (hypothyroidism, panhypopituitarism, congenital adrenal hyperplasia) or a prior anatomic obstructive gastrointestinal malformation (volvulus or gastroschisis). 1, 12, 14 Alternatively, direct pharmacologic effects of an agent on systemic host defense (vitamin E), motility (morphine) or regional blood flow (indomethacin) may result in mucosal injury, increasing the risks for NEC in susceptible neonates. cache = ./cache/cord-022216-k4pi30sd.txt txt = ./txt/cord-022216-k4pi30sd.txt === reduce.pl bib === id = cord-022594-fx044gcd author = Pirko, Istvan title = Demyelinating Disorders of the Central Nervous System date = 2009-05-18 pages = extension = .txt mime = text/plain words = 25103 sentences = 1371 flesch = 46 summary = If a patient presents with a history of two or more attacks, but objective clinical evidence only suggests one lesion, the following additional data is needed to confirm the diagnosis: the disease process has to be disseminated in space as demonstrated by MRI; alternatively, two or more MRI-detected lesions consistent with MS plus positive CSF would suffice to meet the newly defined criteria. The EBM calculations regarding this trial show an RRR of 24%, and ARR of 11%, and an NNT of 9 patients over 2 years in order to prevent one conversion to "clinically definite MS." These two studies provide support for considering early treatment in patients presenting with first attack, in the presence of multiple asymptomatic MRI lesions, but further studies are needed to determine whether this approach will provide a prolonged benefit on disease course. cache = ./cache/cord-022594-fx044gcd.txt txt = ./txt/cord-022594-fx044gcd.txt === reduce.pl bib === id = cord-022527-a0x6lws3 author = nan title = Eosinophils in Human Disease date = 2012-10-12 pages = extension = .txt mime = text/plain words = 56005 sentences = 2997 flesch = 38 summary = The role of the eosinophils as key players in the pathophysiology of asthma has been debated, despite evidence that the cells are present and activated in the airway lumen and tissue 1 of patients with current asthma; are increased in number when asthma is uncontrolled 2 or severe 3 and decreased when asthma is controlled 4 ; and treatment strategies that aim to control airway eosinophilia are significantly more effective and less expensive in improving asthma control 5,6 and decreasing asthma exacerbations compared to guideline-based clinical strategies. 11 Since allergic asthma is primarily a T-helper type 2 (T h 2)-mediated disease, it is not surprising that cytokines driving eosinophilia are T h 2 cell products: specifically, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5), which signal through specific high-affinity cell-surface receptors linked to a common b-chaindall of which can act as eosinophil growth factors that promote formation of eosinophil/basophil (Eo/B) colony-forming units (CFU) in functional assays. cache = ./cache/cord-022527-a0x6lws3.txt txt = ./txt/cord-022527-a0x6lws3.txt === reduce.pl bib === id = cord-023288-sqr33y72 author = nan title = Paediatric SIG: Poster Session date = 2008-03-12 pages = extension = .txt mime = text/plain words = 30158 sentences = 1762 flesch = 53 summary = Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. cache = ./cache/cord-023288-sqr33y72.txt txt = ./txt/cord-023288-sqr33y72.txt === reduce.pl bib === id = cord-022659-chwk2bs4 author = nan title = Abstracts: Poster session date = 2004-10-08 pages = extension = .txt mime = text/plain words = 49153 sentences = 2598 flesch = 49 summary = We investigated the usefulness of informant-based data in Alzheimer's disease (AD) by comparing caregivers' subjective evaluations of 83 probable A D patients' performance on an abbreviated version of the Memory Self-Report Questionnaire to objective evaluations derived from an extensive battery of neuropsychological tests and to clinicians' evaluations. Compared with 89 subjects (mean age 75.2 yr; 34 men, 55 women) with dementia of the Alzheimer type (DAT), there were no significant group differences for comparable Clinical Dementia Rating stages of dementia for measures of language, Activities of Daily Living, or general cognition. The mean age at onset did not differ significantly between handedness groups (F [ l,lOO] = .82), but the mean duration of symptoms ( Alterations in the optical properties of brain can be used to detect pathological changes in patients with Alzheimer's disease (AD). cache = ./cache/cord-022659-chwk2bs4.txt txt = ./txt/cord-022659-chwk2bs4.txt === reduce.pl bib === id = cord-023168-cd7adns8 author = Thachil, Jecko title = Haematological Diseases in the Tropics date = 2013-10-21 pages = extension = .txt mime = text/plain words = 30224 sentences = 1724 flesch = 44 summary = The most useful laboratory measure of iron status Low value is diagnostic in the presence of anaemia Very high values (>100 µg/L) usually exclude iron deficiency' Being an acute-phase protein, it increases in inflammatory conditions, and certain malignancies, making it unreliable Also increased in tissue damage especially of the liver Levels are falsely decreased in vitamin C deficiency and hypothyroidism Erythrocyte zinc protoporphyrin An intermediate in haem biosynthesis and elevated concentrations indicate interrupted haem synthesis due to iron deficiency when zinc is incorporated in place of iron Can be measured on a drop of blood with a portable haematofluorometer Small sample size makes it very useful as a screening test in field surveys, particularly in children, and pregnant women where inflammatory states may not co-exist Red cells should be washed before measurement (serum bilirubin and fluorescent compounds like some drugs can give falsely high values) although not often done Lead poisoning can give falsely high values Rarely acute myeloid leukaemia and sideroblastic anaemia give slightly high values Useful in that it is not increased in thalassaemias WHO recommends normal level >70 µmol/mol haem Iron studies Serum iron concentration represents the iron entering and leaving the circulation. cache = ./cache/cord-023168-cd7adns8.txt txt = ./txt/cord-023168-cd7adns8.txt === reduce.pl bib === id = cord-019490-m1cuuehi author = nan title = Abstracts cont. date = 2015-12-28 pages = extension = .txt mime = text/plain words = 93588 sentences = 5683 flesch = 50 summary = Tigecycline Evaluation Surveillance Trial (TEST) -Global in vitro antibacterial activity against selected species of glucose non-fermenting organisms Objective: Despite the introduction of new antimicrobials to treat resistant gram-positive bacteria, Staphylococcus aureus continues to be a therapeutic challenge for the clinician. Two prospective studies from our centre identified common causes of CAP in India to be Mycoplasma pneumoniae [MP] and Legionella pneumophila [LP] by serology in 11% each, and SPN in 10% by culture of respiratory secretions/blood/ Conclusion: Although SPN is the most common isolate, the rising numbers of gram negative organisms (38%) and atypical pathogens associated with increasing mortality stress the need for review of initial antibiotic choice for adults with higher PORT classes. Conclusion: The spectrum of isolates among our patients were shifting towards gram positive bacteria with high resistance to different groups of antimicrobial agents limiting few choices for alternative therapies for infection control. cache = ./cache/cord-019490-m1cuuehi.txt txt = ./txt/cord-019490-m1cuuehi.txt === reduce.pl bib === id = cord-023622-tul7bonh author = nan title = Rotaviruses of Man and Animals date = 1975-02-01 pages = extension = .txt mime = text/plain words = 1952 sentences = 100 flesch = 51 summary = Certainly bacterial pathogens may cause both sporadic and epidemic gastroenteritis in children, but they cannot be isolated in up to 75% of cases.2, 3 Whilst it is true that some investigations suggest that enteroviruses or adenoviruses may occasionally cause localised outbreaks of gastroenteritis,4-7 others have shown that these viruses may be detected almost as frequently in controls as among patients. Employing negativestaining techniques on fsecal extracts, FLEWETT and his colleagues found similar particles in children with gastroenteritis in Birmingham 13; indeed, if virologists had only looked at such simply prepared specimens, there is no technical reason why these viruses could not have been detected, say, 15 years ago. Thus, existing evidence suggests that rotaviruses are the most important cause of infantile gastroenteritis throughout the world, but as yet only a limited number of specimens have been examined from those tropical areas where mortality-rates are particularly high. cache = ./cache/cord-023622-tul7bonh.txt txt = ./txt/cord-023622-tul7bonh.txt === reduce.pl bib === id = cord-023303-fxus38mp author = nan title = Lung Cancer/Bronchology SIGs: Combined Poster Session date = 2008-03-12 pages = extension = .txt mime = text/plain words = 30161 sentences = 1760 flesch = 53 summary = Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. cache = ./cache/cord-023303-fxus38mp.txt txt = ./txt/cord-023303-fxus38mp.txt === reduce.pl bib === id = cord-023302-p9pxz44a author = nan title = Cystic Fibrosis SIG: Poster Session date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32008 sentences = 1915 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023302-p9pxz44a.txt txt = ./txt/cord-023302-p9pxz44a.txt === reduce.pl bib === id = cord-023033-tgt69ir6 author = nan title = Poster Session (pp. 78A–178A) date = 2006-02-10 pages = extension = .txt mime = text/plain words = 16102 sentences = 855 flesch = 45 summary = Methods: We performed a retrospective analysis comparing outcomes, and the incidence, timing, and severity of histologic recurrence of HCV following transplantation in patients who underwent living donor liver transplant compared to recipients of cadaveric organs. Local liver immune responses are thought to play a major role in chronic autoimmune diseases directed at biliary epithelium.Using the apical sodium dependent bile acid transporter (ASBT) promoter to drive biliary epithelial cell -specific expression of a membrane form of ovalbumin (OVA), we have previously developed OVA-BIL transgenic mice. Thus, our AIM was to ascertain whether Kupffer cells express death ligands and contribute to hepatocyte apoptosis and liver fibrosis in the bile duct ligated mouse, an animal model of cholestasis. Control experiments confirmed that Y2 protein inhibited IFNa-induced ISRE-mediated signaling in Huh-T7 cells; relative luciferase activity was reduced from 653 (pH771 IFNP nAb increased HCV core Ag replication by 42% and 23% compared to no treatment (p=O.O1). cache = ./cache/cord-023033-tgt69ir6.txt txt = ./txt/cord-023033-tgt69ir6.txt === reduce.pl bib === id = cord-023311-7wqdlha4 author = nan title = Oral Session date = 2010-11-24 pages = extension = .txt mime = text/plain words = 17248 sentences = 956 flesch = 51 summary = Methods We determined the usefulness of preoperative lung function by spirometry in predicting regression of pulmonary hypertension after surgical correction of mitral stenosis among 20 patients who underwent mitral valve surgery at Philippine Heart Center from July to December 2009. Elderly patients exhibited a signifi cantly higher mortality rate that was independently associated with the following: age; residence status; confusion, urea, respiratory frequency and blood pressure (CURB) score; comorbid conditions; and failure of initial therapy. Methods A total of 40 patients (Male: 50%; Female: 50%) admitted and diagnosed with HAP at our Center were followed up to investigate the rate of adherence of physicians on the diagnosis and treatment of HAP based on Level I and II ATS/IDSA 2008 recommendations and to determine its association with outcome (mortality, mechanical ventilation, ICU stay, hospital stay). cache = ./cache/cord-023311-7wqdlha4.txt txt = ./txt/cord-023311-7wqdlha4.txt === reduce.pl bib === === reduce.pl bib === id = cord-023669-3ataw6gy author = Masur, Henry title = Critically Ill Immunosuppressed Host date = 2009-05-15 pages = extension = .txt mime = text/plain words = 11194 sentences = 576 flesch = 34 summary = As the population of patients with cancer, organ transplants, vasculitides, and human immunodefi ciency virus (HIV) infection has grown, intensivists are seeing more and more patients with altered immunity. For instance, if a patient presents with severe hypoxemia and diffuse pulmonary infi ltrates, a health care provider who recognizes a prior splenectomy as the major predisposition to infection would focus the diagnostic evaluation and the empiric therapy on Streptococcus pneumoniae and Haemophilus infl uenzae. Patients with HIV infection develop clinical disease as a result of three basic processes: the direct effect of HIV on specifi c organs (e.g., cardiomyopathy, enteropathy, dementia); immunologically mediated processes (e.g., glomerulonephritis, thrombocytopenia); or opportunistic infections and tumors that are enabled by HIV-induced immunosuppression. For instance, if a patient with HIV infection and a CD4+ T lymphocyte count of 700 cells/µL presents with diffuse pulmonary infi ltrates, the diagnostic evaluation and empiric antimicrobial regimen should focus on S. cache = ./cache/cord-023669-3ataw6gy.txt txt = ./txt/cord-023669-3ataw6gy.txt === reduce.pl bib === id = cord-023186-gqltd6u0 author = nan title = Poster Sessions date = 2019-06-27 pages = extension = .txt mime = text/plain words = 14365 sentences = 814 flesch = 55 summary = Methods: This is a one-year retrospective study that was conducted in our pediatric intensive care unit (PICU) comparing the intervention failure rate of three different Noninvasive respiratory support modalities (bi-level positive airway pressure (BIPAP), continuous positive airway pressure (CPAP) and HFNC) for infants and young children between the ages of 1 month and 2 years admitted with the diagnosis of bronchiolitis. The aim of the study was to determine the association between Methods: Ninety children aged between > 28 days to < 5 years hospitalized with diagnosis of severe CAP in the Pediatric Department of West Nusa Tenggara Province General Hospital from January to October 2018 were enrolled. Arterial blood gases, respiratory rate, peak inspiratory pressure (PIP) and mean airway pressure (MAP) of rat lung during respiratory support, wetto-dry lung weight ratio, lung homogenate and/or bronchoalveolar lavage fluid tumor necrosis factor-α, macrophage inflammatory protein-2, interleukin-6 and total protein levels were measured and compared among groups after study completion. cache = ./cache/cord-023186-gqltd6u0.txt txt = ./txt/cord-023186-gqltd6u0.txt === reduce.pl bib === id = cord-024233-hrzpxdh0 author = nan title = In This Issue/Research Watch/News in Brief date = 2020-04-24 pages = extension = .txt mime = text/plain words = 3258 sentences = 166 flesch = 49 summary = Circulating tumor DNA analysis to assess risk of progression after long-term response to PD-(L)1 blockade in NSCLC Optimal treatment duration of immune checkpoint inhibitors (ICI) in non-small-cell lung cancer (NSCLC) is not well established. Hellman and colleagues evaluated blood samples using Cancer Personalized Profiling by Deep Sequencing (CAPP-Seq) of 31 advanced NSCLC patients with baseline detectable ctDNA and experiencing long-term benefit to PD-(L)1 blockade (defined as progression-free survival-PFS 12 months) in surveillance. Baseline plasma tumor mutation burden predicts response to pembrolizumab-based therapy in patients with metastatic non-small cell lung cancer The phase III KEYNOTE 010 trial demonstrated survival improvement with pembrolizumab as compared with docetaxel in previously treated PD-L1 positive (cut-off 1%) advanced non-small-cell lung cancer (NSCLC) patients. Following this decision, brigatinib is now indicated as monotherapy for the treatment of adult patients with Anaplastic Lymphoma Kinase (ALK) positive advanced non-small-cell lung cancer previously not treated with ALK inhibitors. cache = ./cache/cord-024233-hrzpxdh0.txt txt = ./txt/cord-024233-hrzpxdh0.txt === reduce.pl bib === id = cord-023216-avn8f2w3 author = nan title = Symposium summaries date = 2004-10-18 pages = extension = .txt mime = text/plain words = 55670 sentences = 2569 flesch = 45 summary = • relevant past history • recently recommended home physiotherapy program including inhalation therapy (agents, order and timing), airway clearance therapy (ACT) and physical exercise program and adherence • the possibility of gastroesophageal reflux 5 in relation to physiotherapy • clinical status including subjective and objective measures of the following -amount, color, consistency and ease of expectoration of sputum -oximetry/pulmonary function tests/peak expiratory flow rate -breath sounds on auscultation, respiratory rate and pattern of breathing -exercise tolerance (current activity & incidental exercise/ exercise tolerance tests) -musculo-skeletal problems (posture, pain, muscle tightness/weakness, oedema) -urinary incontinence during coughing and forced expirations Assessment of health related quality of life (HRQOL) in children and adolescents with cystic fibrosis (CF) is important to better understand disease and treatment-related factors that impact function and well-being, and to evaluate the effectiveness of therapies and methods of drug delivery. cache = ./cache/cord-023216-avn8f2w3.txt txt = ./txt/cord-023216-avn8f2w3.txt === reduce.pl bib === id = cord-023017-k6edtg58 author = nan title = AASLD Abstracts (pp. 282A–382A) date = 2006-02-10 pages = extension = .txt mime = text/plain words = 65796 sentences = 3553 flesch = 51 summary = 14/55 (25%) patients in AC who did not discontinue by week 24 received ribavirin dose reduction in comparison to 31/108 ( The clinical outcome in response to combination therapy for treatment of chronic hepatitis C virus (HCV) infection appears to be different for Caucasian versus African American patients. Over the period of combination therapy, most patients in which serum virus titers were reduced to non detectable levels had significant increases in T cell responses to HCV proteins. CHRONIC Background: Recent large prospective trials demonstrated that the combination therapy of interferon (1FN)-alphalribavirin significantly increased the ratio of a sustained virological response in patients with chronic hepatitis C in comparison with IFN monotherapy, especially in patients with high HCV-RNA titer and genotype lb. Results: Patients with chronic HCV infection showed higher MxA gene expression levels than healthy controls, indicating that hepatitis C virus induces IFN production. cache = ./cache/cord-023017-k6edtg58.txt txt = ./txt/cord-023017-k6edtg58.txt === reduce.pl bib === id = cord-023308-af5nihyi author = nan title = COPD SIG: Poster Session 2 date = 2008-03-12 pages = extension = .txt mime = text/plain words = 30159 sentences = 1761 flesch = 53 summary = Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. cache = ./cache/cord-023308-af5nihyi.txt txt = ./txt/cord-023308-af5nihyi.txt === reduce.pl bib === id = cord-023873-fidpskcs author = Meersseman, Wouter title = Invasive Aspergillosis in the Intensive Care Unit: Beyond the Typical Haematological Patient date = 2009-05-04 pages = extension = .txt mime = text/plain words = 4137 sentences = 208 flesch = 39 summary = Finally, to date, the diagnostic utility of recently available non-culture based microbiological tools, including the detection of fungal antigens and the detection of Aspergillus-specific DNA through polymerase chain reaction (PCR) techniques, has not been properly validated in the non-haematology ICU population. In addition, typical ICU patients such as those with chronic obstructive pulmonary disease (COPD) or liver disorders were not considered amongst hosts at high risk for IA in the recently updated EORTC/MSG guidelines [2] . In a recent study published by our group [10] , patients with fever new lung infiltrates were screened for IA using galactomannan testing in bronchoalveolar (BAL) fluid. The concept that increasing fungal burden due to specific ICU treatments for other diseases than IA (e.g. steroids for septic shock) parallels the progression from subclinical to clinical aspergillosis, needs to be explored with more sensitive markers (e.g. PCR). Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease cache = ./cache/cord-023873-fidpskcs.txt txt = ./txt/cord-023873-fidpskcs.txt === reduce.pl bib === id = cord-023314-rwjxk8v4 author = nan title = Asthma & Allergy SIG: Poster Session 1 date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32009 sentences = 1912 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023314-rwjxk8v4.txt txt = ./txt/cord-023314-rwjxk8v4.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-023306-3gdfo6vd author = nan title = TSANZ Oral Abstracts date = 2010-03-01 pages = extension = .txt mime = text/plain words = 23387 sentences = 1370 flesch = 54 summary = Conflict of Interest No. Purpose We examined age trends in the distribution of stage at diagnosis in patients presenting with non-small cell lung cancer (NSCLC) at tertiary hospitals. Methods Eleven healthy male subjects, aged 28(8) (SD) years completed separate visits with (a) no restriction and (b) chest wall strapping to reduce FVC by 30 (7) Introduction Glossopharyngeal breathing (GPB) is used by competitive breath-hold divers to increase lung gas content above TLC to improve performance. Our DC culture results showed that both MHC-I and MHC-II expression on DCs from COPD were significantly down regulated compare to healthy controls, which could affect MHC restricted Ag presentation, and lead to a failure to activate responder T cells. cache = ./cache/cord-023306-3gdfo6vd.txt txt = ./txt/cord-023306-3gdfo6vd.txt === reduce.pl bib === === reduce.pl bib === id = cord-024130-kgzegwon author = Ankita title = COVID-19: An Ophthalmological Update date = 2020-04-30 pages = extension = .txt mime = text/plain words = 2845 sentences = 190 flesch = 51 summary = Conjunctival secretions from patients and asymptomatic contacts of COVID-19 cases may also spread the disease further into the community. In view of the presence of coronavirus in body fluids of patients, and SARS-CoV-2 being similar to SARS-CoV, the risk of transmission through conjunctival secretion and tear cannot be neglected. Patients with conjunctivitis may initially report to an ophthalmologist, possibly making the eye care physician to first suspect a case of COVID-19 (Lu et al. According to a recently published literature on COVID-19 conjunctivitis, tear sample and conjunctival swab are reported to be positive for the novel coronavirus. As per recent AAO guidelines, as a response to the state of national emergency due to COVID-19, eye care practitioners should reduce the number of outpatient The following preventive measures should be taken by the ophthalmologist in the outpatient clinic for general patients (Group 1 and 2) during such outbreaks: Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection cache = ./cache/cord-024130-kgzegwon.txt txt = ./txt/cord-024130-kgzegwon.txt === reduce.pl bib === === reduce.pl bib === id = cord-024614-6bu3zo01 author = Tang, Daxing title = Prevention and control strategies for emergency, limited-term, and elective operations in pediatric surgery during the epidemic period of COVID-19 date = 2020-03-26 pages = extension = .txt mime = text/plain words = 5846 sentences = 300 flesch = 43 summary = Based on the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19, the authors proposed some concrete measures and practical strategies of managing emergency, limited-term, and elective pediatric surgeries during the epidemic period. Based on the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19, the authors proposed some concrete measures and practical strategies of managing emergency, limited-term, and elective pediatric surgeries during the epidemic period. Based on the "Technical Guidelines for the Prevention and Control of New Coronavirus Infection in Medical Institutions (First Edition)," 17 "Diagnosis and Treatment Plan on the New Coronavirus inflicted pneumonia (Sixth trial edition, revised)" 2 (both released by the National Health Commission of China), "Recommendations for the Prevention and Control of General Surgery in the Background of New Coronavirus Outbreak," 6 and other relevant latest reports, we propose the following control measures and practical strategies for pediatric surgery practice during the COVID-19 epidemic. cache = ./cache/cord-024614-6bu3zo01.txt txt = ./txt/cord-024614-6bu3zo01.txt === reduce.pl bib === id = cord-023333-b7w9zrl6 author = nan title = Oeld/Population Health SIG: Poster Session date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32009 sentences = 1914 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023333-b7w9zrl6.txt txt = ./txt/cord-023333-b7w9zrl6.txt === reduce.pl bib === === reduce.pl bib === id = cord-024120-3eemj37r author = Schiff, Gordon D. title = An Interview with Gordon D. Schiff date = 2020-04-29 pages = extension = .txt mime = text/plain words = 5175 sentences = 267 flesch = 49 summary = [10] [11] [12] I also worked on early efforts to leverage health information technology (IT) by linking lab and pharmacy data, 13, 14 demonstrate the value of integrating drug indication into computerized physician order entry (CPOE), 15 identify safety vulnerabilities in current CPOE systems, 16, 17 and conceptualize ways redesigning electronic clinical documentation redesign could prevent diagnostic errors. I believe we have squandered much of its potential to help us achieve the World Health Organization (WHO) Global Patient Safety Challenge aim of "Medication without Harm." 26 These areas of failure include poorly designed decision support, introduction of new types of errors associated with using CPOE systems, frustratingly inefficient work-flows and screens that lead to dangerous workarounds, suboptimal linkages between prescribing systems and pharmacy dispensing databases resulting in prescribers not knowing what drugs have actually been dispensed by pharmacies and pharmacies not knowing when drugs are discontinued by physicians, inadequate monitoring of patients prescribed medications (including adverse effects and adherence), and failure of prescribing systems to help prescribers know the drug-of-choice for a particular indication. cache = ./cache/cord-024120-3eemj37r.txt txt = ./txt/cord-024120-3eemj37r.txt === reduce.pl bib === id = cord-024956-oht0v33s author = Yu, Minhua title = Thin-section Chest CT Imaging of Coronavirus Disease 2019 Pneumonia: Comparison Between Patients with Mild and Severe Disease date = 2020-04-23 pages = extension = .txt mime = text/plain words = 2496 sentences = 157 flesch = 50 summary = title: Thin-section Chest CT Imaging of Coronavirus Disease 2019 Pneumonia: Comparison Between Patients with Mild and Severe Disease The purpose was to compare radiological characteristics of COVID-19 pneumonia on thin-section CT upon admission between patients with mild and severe disease. Thus, the purpose of our current study was to compare radiological characteristics of COVID-19 pneumonia on thin-section CT between patients with mild and severe disease. We studied the findings on chest CT at hospital presentation in patients diagnosed with COVID-19 pneumonia, focusing our comparisons between the patients with mild and severe disease. As for characteristics in CT images, COVID-19 pneumonia seems to be more extensive in the severe form of disease, involving a larger number of lung segments. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in wuhan, china cache = ./cache/cord-024956-oht0v33s.txt txt = ./txt/cord-024956-oht0v33s.txt === reduce.pl bib === id = cord-024073-243addff author = Richards, Guy title = COVID-19 and the Rationale for Pharmacotherapy: A South African Perspective date = 2020-04-17 pages = extension = .txt mime = text/plain words = 3402 sentences = 188 flesch = 49 summary = All of the patients had deteriorated despite routine therapies in the previous week, and the agent is now listed as a treatment option for severe or critical cases with elevated IL-6 in the National Health Commission of the People's Republic of China COVID-19 Diagnosis and Treatment Guide.(35) A very recent case study has described the successful use of Tmab in a patient on maintenance therapy for multiple myeloma who had received bortezomib, thalidomide and dexamethasone therapy approximately 4 years previously and had been on thalidomide maintenance since then. A systematic review of observational studies of corticosteroids administered to patients with SARS-CoV-1 reported no survival benefit and possible harm and increased mortality and secondary infections were noted with severe influenza A; however, the evidence quality was low.(43) A subsequent study noted in the WHO guidelines found no effect on mortality. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study cache = ./cache/cord-024073-243addff.txt txt = ./txt/cord-024073-243addff.txt === reduce.pl bib === === reduce.pl bib === id = cord-023509-tvqpv6fp author = Corrin, Bryan title = Occupational, environmental and iatrogenic lung disease date = 2011-03-02 pages = extension = .txt mime = text/plain words = 42576 sentences = 2457 flesch = 45 summary = As a general rule, exposure to silica dust extends over many years, often 20 or more, before the symptoms of silicosis first appear: by the time the disease becomes overt clinically, much irreparable damage has been inflicted on the lungs. Confusingly, the term 'acute silicosis' has since been applied to a further effect of heavy dust exposure in tunnellers, sand blasters and silica flour workers, namely pulmonary alveolar lipoproteinosis (see below), 71, 72 whilst the terms 'accelerated silicosis' or 'cellular phase silicosis' have been substituted for 'acute silicosis' in referring to the rapid development of early cellular lesions. Asbestosis is defined as diffuse interstitial fibrosis of the lung caused by exposure to asbestos dust. The finely divided fume of several metals is highly toxic to the lungs and capable of producing severe acute and chronic damage to both the conductive airways and the alveoli, resulting in acute tracheobronchitis and bronchiolitis, diffuse alveolar damage, obliterative bronchiolitis and pulmonary fibrosis. cache = ./cache/cord-023509-tvqpv6fp.txt txt = ./txt/cord-023509-tvqpv6fp.txt === reduce.pl bib === === reduce.pl bib === id = cord-023833-xpfibjh2 author = Kilickaya, O. title = Structured Approach to Early Recognition and Treatment of Acute Critical Illness date = 2014 pages = extension = .txt mime = text/plain words = 3386 sentences = 164 flesch = 36 summary = Embracing a safety culture, limiting the number of steps ('less is more'), enhancing and prompting clear prioritized information, patient-and familycentered care delivery (integration of values, beliefs and advanced directives), improved communication and coordination (hand-offs, physician extenders) are all needed for safe and efficient critical care delivery. The advances in information technology, medical informatics and human factors engineering, have provided a tremendous opportunity for the development of novel and user-friendly checklists and decision support tools that can be widely applied in a complex and busy acute care settings [9] . To be successful, these applications need to reduce information overload and the potential for error, facilitate adherence to practice guidelines and enable clear communication and collaborative decision Fig. 3 Outline of the structured approach to early recognition and treatment of acute illness. A structured, reliable and error-free approach to the management of acutely ill or injured patients during the early, most vulnerable period is facilitated by point-of-care checklists and algorithms containing brief prioritized information. cache = ./cache/cord-023833-xpfibjh2.txt txt = ./txt/cord-023833-xpfibjh2.txt === reduce.pl bib === id = cord-025157-7b3v5yct author = Darreau, C. title = Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study date = 2020-05-24 pages = extension = .txt mime = text/plain words = 3615 sentences = 206 flesch = 41 summary = In the multivariate analysis, seven parameters were significantly associated with early intubation and ranked as follows by decreasing weight: Glasgow score, center effect, use of accessory respiratory muscles, lactate level, vasopressor dose, pH and inability to clear tracheal secretions. Several arguments have been put forward in favor of early ventilatory support in septic shock patients, as part of the bundle that should be introduced in the first hours Open Access *Correspondence: nicolas.lerolle@univ-angers.fr 31 Medical Intensive Care Unit, Angers University Hospital, Angers, France Full list of author information is available at the end of the article of care together with antibiotic, fluid, and vasopressor use. To assess use, timing and factors associated with tracheal intubation in septic shock patients, we conducted a multicenter observational prospective study in 30 intensive care units (ICUs) in France and Spain. cache = ./cache/cord-025157-7b3v5yct.txt txt = ./txt/cord-025157-7b3v5yct.txt === reduce.pl bib === id = cord-023239-06a03o14 author = nan title = II. Topic Sessions date = 2016-06-10 pages = extension = .txt mime = text/plain words = 33469 sentences = 1470 flesch = 39 summary = The basics of inhaler technique / device / adherence / allergen exposure are all being maintained A retrospective analysis of follow-up of children with difficult asthma for up to six years revealed that those in whom underlying modifiable factors were identified and addressed had an improvement in lung function and reduction in exacerbations over time, while being able to reduce maintenance dose of inhaled steroids such that the majority fell below the threshold for problematic severe asthma 4 . Long-term follow up of children investigated in infancy and reassessed in later childhood have so far showed that reduced baseline lung function in symptomatic infants was significantly associated with subsequent respiratory morbidity as well as with the need of anti-asthma medication at the age of 3 years. cache = ./cache/cord-023239-06a03o14.txt txt = ./txt/cord-023239-06a03o14.txt === reduce.pl bib === id = cord-024189-t7mbsr25 author = Weyand, Cornelia M. title = Vasculitides date = 2008 pages = extension = .txt mime = text/plain words = 26631 sentences = 1415 flesch = 40 summary = A relatively disease-specifi c manifestation of GCA that is present in about half of the patients is jaw claudication: pain in the masseter or temporalis muscles caused by compromised blood fl ow in the extracranial branches of the carotid artery. Although a high erythrocyte sedimentation rate (ESR) is usually considered a hallmark of GCA, in a recent study 25% of all patients with positive temporal artery biopsies had normal ESRs before the initiation of glucocorticoid therapy (16) . Upregulation of acute phase reactants is helpful in distinguishing PMR from other pain syndromes, yet (as in GCA and TA) not all patients with active disease have elevated markers of infl ammation within their serum. Kawasaki's disease (KD), once known as mucocutaneous lymph node syndrome, is a systemic infl ammatory disorder occurring in children that is accompanied by vasculitis and a risk of coronary artery aneurysms. cache = ./cache/cord-024189-t7mbsr25.txt txt = ./txt/cord-024189-t7mbsr25.txt === reduce.pl bib === === reduce.pl bib === id = cord-019347-tj3ye1mx author = nan title = ABSTRACT BOOK date = 2010-02-19 pages = extension = .txt mime = text/plain words = 107926 sentences = 6940 flesch = 53 summary = Method:Case Report:A 15y/o w/f athlete presented with a two month history of recurrent hives and angioedema which she associated with ingestion of Halloween candy .One week before evaluation she had hives with Coconut as well.Her history was othewise unremarkable except for recurrent UTI'S, annual sinusitis, pneumonia in 1998 as well as migraines.She denied sexual activity.Her physical exam was normal.Results:An evaluation for autoimmune disease revealed normal ESR, ANA, DSDNA, mono and hepatitis serology as well as lyme titers however her CH50 was low17u/ml(normal 26-58U/ml)and evaluation of complement revealed c4 14mg/dl(normal 16-47mg//dl)and c2 <1.3mg/dl(normal 1.6-3.5mg/dl)with normal c3, c5-c9.Her father had nor-malc4 but c2 was 1.4mg/dl (normal 1.6-3.5mg/dl)Her sister had c2 of 1.5mg/dl and normal c4 and her mother had normal c2 and c4.Her workup included positive prick skin test to ragweed, ash and grass and she was started on Rhinocort and Clarinex seasonally.She has been followed for one year with resolution of hives and is asymptomatic.Her diagnosis had been confirmed by a pediatric rheumatologist.Conclusion;We present an atypical case of C2 complement deficiency in an currently asymptomatic individual. cache = ./cache/cord-019347-tj3ye1mx.txt txt = ./txt/cord-019347-tj3ye1mx.txt === reduce.pl bib === id = cord-025666-u8w4sk07 author = Edgar, DW title = Seeding the value based health care and standardised measurement of quality of life after burn debate date = 2020-05-30 pages = extension = .txt mime = text/plain words = 1668 sentences = 89 flesch = 54 summary = These surveys provide us with an important view of an individual's health across multiple domains which go beyond any pathophysiological measure and there is substantial literature validating PROMs in particular, for use after burn injuries [6, 7] . Notwithstanding, the availability of computerised adaptive testing, the instruments established and emerging include: a) Medical Outcome Study Short Form -36 item (SF-36) [9] for generic QoL measurement in adult burn patients. The SF-36 is a widely applied instrument and the most often used generic instrument to assess QoL in burns [8, 10] , it is validated for use in the adult burn patient population [11] , and it covers many domains that are also covered by the most applied burn specific QoL measure [12] . A systematic review of patient-reported outcome measures used in adult burn research Demonstration of the validity of the SF-36 for measurement of the temporal recovery of quality of life outcomes in burns survivors cache = ./cache/cord-025666-u8w4sk07.txt txt = ./txt/cord-025666-u8w4sk07.txt === reduce.pl bib === id = cord-027551-a92lv4sh author = Pinto, Eleonora title = QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer date = 2020-06-22 pages = extension = .txt mime = text/plain words = 4415 sentences = 219 flesch = 38 summary = We have therefore hypothesized that, similar to what was observed with the sleep impairment [16] , the early postoperative HRQL could be improved by ameliorating the quality of nutrition and respiration after esophagectomy and designing a randomized control trial to assess if the adoption of nutritional and respiratory counseling may be effective in enhancing the quality of postoperative QoL after esophagectomy for cancer. This randomized controlled trial aimed to assess the effectiveness of nutritional counseling and/or respirology counseling on postoperative quality of life after esophagectomy for cancer. Thus, the aim of this study was to evaluate the effect of the nutritional and respiratory counseling on quality of life after esophagectomy for cancer. However, nutritional counseling did not influence appetite loss, global quality of life, or eating issues at 3 months after surgery, and receiving nutritional counseling did not result in any significant changes in additional nutritional measures (PA, FFm, Kcal, prot, BMI). Feb-Mar) Longterm nutritional outcome and health related quality of life of patients following esophageal cancer surgery: a meta-analysis cache = ./cache/cord-027551-a92lv4sh.txt txt = ./txt/cord-027551-a92lv4sh.txt === reduce.pl bib === id = cord-025172-qg3jxgch author = Covarrubias, Jose title = Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis date = 2020-05-24 pages = extension = .txt mime = text/plain words = 2816 sentences = 154 flesch = 51 summary = We hypothesized mortality and rates of infectious and inflammatory complications would be higher in HIV positive (HIV+) trauma patients. We hypothesized that a HIV+ trauma cohort would have increased mortality rates, infectious complications (i.e., pneumonia, urinary tract infection (UTI), and sepsis), and inflammatory complications [i.e., acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI)], compared to a propensity-matched HIV− group. TQIP patient inclusion criteria consists of age ≥ 16, presence of at least one valid trauma International Statistical Classification of Diseases and Related Health Problems (ICD) diagnosis code, blunt or penetrating mechanisms of injury, Abbreviated Injury Scale (AIS) score ≥ 3, and having data for hospital or emergency department disposition [13] . Using seven years of data derived from the TQIP database, we demonstrated no differences in mortality or rates of infectious complications between HIV+ and HIV− trauma patients. cache = ./cache/cord-025172-qg3jxgch.txt txt = ./txt/cord-025172-qg3jxgch.txt === reduce.pl bib === === reduce.pl bib === id = cord-024833-e6vcf4un author = nan title = Forum date = 2019-12-19 pages = extension = .txt mime = text/plain words = 8110 sentences = 391 flesch = 48 summary = Approximately 80% of US hospitals rely on data and recommendations from the ECRI Institute to protect patients from unsafe practices and ineffective products, while the ISMP's efforts to improve safety in patients have resulted in changes to clinical practice and public policy, including improvements in drug labelling, packaging, preparation and administration. The FDA has now announced the availability of a draft document entitled "Best Practices in Drug and Biological Product Postmarket Safety Surveillance for FDA Staff", which outlines the agency's approach to timely postmarketing analyses of drugs and biologics, and "includes a high-level overview of tools, methods, and signal detection and evaluation activities, using varied data sources, for drug safety surveillance to provide a broader context and a general overview of our overarching effort and commitment in this area", says Woodcock. Analysis of spontaneous ADR reports to the European Medicine Agency's EudraVigilance database has identified new safety signals for asthma drugs in paediatric patients, say authors of a study published in Drug Safety. cache = ./cache/cord-024833-e6vcf4un.txt txt = ./txt/cord-024833-e6vcf4un.txt === reduce.pl bib === id = cord-025990-nj4ah2yz author = Konca, Capan title = Susceptibility Patterns of Multidrug-Resistant Acinetobacter baumannii date = 2020-06-04 pages = extension = .txt mime = text/plain words = 3224 sentences = 188 flesch = 47 summary = OBJECTIVES: To investigate the antimicrobial resistance patterns of multidrug-resistant Acinetobacter baumannii (MDRAB) in patients in pediatric intensive care units (PICU) in order to determine a guide for the empirical antibiotic treatment of MDRAB. Thus, in order to determine a guide for the empirical antibiotic treatment of MDRAB, the authors investigated the antimicrobial resistance patterns of MDRAB in patients in pediatric intensive care units (PICUs). In 2016, the isolates were found to have a resistance rate of above 90% against all antibiotics except for colistin and trimethoprim/sulfamethoxazole (Table 3 ). In a worrying study of MDRAB antibiotic susceptibility, it was reported that the colistin resistance rate increased to 35.7% in Iran [19] . A 5-year surveillance study on antimicrobial resistance of Acinetobacter baumannii clinical ısolates from a tertiary Greek hospital Antimicrobial susceptibility patterns of an emerging multidrug resistant nosocomial pathogen: Acinetobacter baumannii cache = ./cache/cord-025990-nj4ah2yz.txt txt = ./txt/cord-025990-nj4ah2yz.txt === reduce.pl bib === id = cord-025170-dtbm4ue1 author = Malbrain, Manu L. N. G. title = Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA) date = 2020-05-24 pages = extension = .txt mime = text/plain words = 9180 sentences = 454 flesch = 39 summary = Resuscitation fluids are used to correct an intravascular volume deficit or acute hypovolemia; replacement solutions are prescribed to correct existing or developing deficits that cannot be compensated by oral intake alone [6] ; maintenance solutions are indicated in hemodynamically stable patients that are not able/allowed to drink water in order to cover their daily requirements of water and electrolytes [10, 11] . Despite the unexpectedly low volume of crystalloids, the authors found a small difference in the primary outcome, i.e., the incidence of major adverse kidney events within 30 days (composite of death, new renal replacement therapy or persistent renal dysfunction) in favor of balance solutions. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: The SPLIT randomized clinical trial Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial cache = ./cache/cord-025170-dtbm4ue1.txt txt = ./txt/cord-025170-dtbm4ue1.txt === reduce.pl bib === id = cord-026846-3u3x52f8 author = nan title = Inside This Issue date = 2020-06-22 pages = extension = .txt mime = text/plain words = 359 sentences = 22 flesch = 48 summary = The authors pooled data on 19,833 patients from 18 randomized trials evaluating outcomes after percutaneous coronary intervention, categorized according to the presence of angiography core laboratory-confirmed moderate or severe coronary artery calcification in any target lesion. This has resulted in an inability to care for patients with valvular and structural heart disease in a timely fashion, potentially placing these patients at increased risk for adverse cardiovascular complications, including CHF and death. In this document, the authors suggest guidelines for how to triage patients in need of structural heart disease interventions and provide a framework for how to decide when it may be appropriate to proceed with intervention despite the ongoing pandemic. In particular, the authors address the triage of patients in need of transcatheter aortic valve replacement and percutaneous mitral valve repair. The authors also address procedural issues and considerations for the function of structural heart disease teams during the COVID-19 pandemic. cache = ./cache/cord-026846-3u3x52f8.txt txt = ./txt/cord-026846-3u3x52f8.txt === reduce.pl bib === id = cord-025176-f0frlpwh author = Coimbra, Raul title = Resuming elective surgical services in times of COVID-19 infection date = 2020-05-19 pages = extension = .txt mime = text/plain words = 2884 sentences = 142 flesch = 41 summary = 15 Most recommendations from public health officials have suggested that a steady decrease in the number of new COVID-19 cases over a period of 14 days (decreased incidence), associated with a similar trend in hospital and ICU admission, is necessary to consider resuming elective surgery (box 1). However, it is important that a staged system be implemented with partial reopening followed by interval full reassessment of the system, as the incidence of COVID-19 infection may have decreased further, allowing the opening of more operating rooms, increasing the overall number of procedures performed. After a functional period in stage 1, a reassessment of the COVID-19 infection in the community and in the hospital should occur to determine if adding operating room capacity and increasing the number of surgical cases is warranted. cache = ./cache/cord-025176-f0frlpwh.txt txt = ./txt/cord-025176-f0frlpwh.txt === reduce.pl bib === id = cord-026879-gwzrdeb1 author = Zarrintan, Armin title = Rapidly progressive COVID-19 viral pneumonia: a report of two patients with a focus on imaging findings date = 2020-06-16 pages = extension = .txt mime = text/plain words = 1748 sentences = 103 flesch = 53 summary = CASE PRESENTATION: In the present case report, we discuss two patients who presented with mild symptoms and CT imaging not suggestive of COVID-19, but subsequently had a rapid deterioration, with severe involvement happening in CT imaging. A chest CT scan was obtained from the patient which showed nonspecific findings (few linear and subsegmental atelectasis at lower lobes) which were not suggestive of COVID-19. The patient again presented to the emergency Fig. 1 The first and second rows show the chest CT scan which was obtained at the emergency department, which shows no significant findings consistent with COVID19 except some linear atelectasis. In conclusion, the clinical course of COVID-19 may not follow that of which is presented in available scientific literature, and more attention should be paid to patients not being treated in hospitals, as they can present severe symptoms without any prior radiologic signs. cache = ./cache/cord-026879-gwzrdeb1.txt txt = ./txt/cord-026879-gwzrdeb1.txt === reduce.pl bib === id = cord-027266-jdti1pwa author = Derevitskii, Ilya V. title = The Atrial Fibrillation Risk Score for Hyperthyroidism Patients date = 2020-05-23 pages = extension = .txt mime = text/plain words = 4049 sentences = 274 flesch = 52 summary = In the first approach, the authors study risk factors for atrial fibrillation, predicting the probability of AF development for a specific period using regression analysis. Using the system for ranking we need to create an easy-to-use and interpretable model for assessing the risk of developing atrial fibrillation in patients with thyrotoxicosis. The main objective of the study is to create a practical method for assessing the risk of developing atrial fibrillation in a patient with thyrotoxicosis. The age and heart rate detected at the first examination also increase the probability of atrial fibrillation in patients with thyrotoxicosis and supraventricular extrasystole. This decision tree is a fairly simple and well-interpreted method that can be useful as part of a support and decision-making system for medical professionals working with patients The Atrial Fibrillation Risk Score for Hyperthyroidism Patients with thyrotoxicosis. cache = ./cache/cord-027266-jdti1pwa.txt txt = ./txt/cord-027266-jdti1pwa.txt === reduce.pl bib === id = cord-023913-pnjhi8cu author = Foreman, Stephen title = Broader Considerations of Medical and Dental Data Integration date = 2011-10-08 pages = extension = .txt mime = text/plain words = 47663 sentences = 2231 flesch = 44 summary = So while there has been no shortage of effort paid to improving Medicare, the one common theme in all of the recent initiatives is that dental care has been conspicuously 1 A new study by Hedlund, Jeffcoat, Genco and Tanna funded by CIGNA of patients with Type II diabetes and periodontal disease found that medical costs of patients who received maintenance therapy were $2483.51 per year lower than patients who did not. Examples of integrated care models do exist, such as that presented by (Heuer 2007 ) involving school-linked and school-based clinics with an "innovative health infrastructure." According to Heuer, "Neighborhood Outreach Action for Health (NOAH)" is staffed by two nurse practitioners and a part-time physician to provide "primary medical services to more than 3,200 uninsured patients each year" in Scottsdale, Arizona. cache = ./cache/cord-023913-pnjhi8cu.txt txt = ./txt/cord-023913-pnjhi8cu.txt === reduce.pl bib === id = cord-026392-cvb44v5v author = Dahlberg, Jørgen title = Barriers and challenges in the process of including critically ill patients in clinical studies date = 2020-06-08 pages = extension = .txt mime = text/plain words = 4780 sentences = 256 flesch = 49 summary = RESULTS: Among 279 eligible critically ill patients, 204 (73%) were omitted from the study due to challenges and barriers in the inclusion process. Previous studies have identified obstacles when performing research in critically ill patients at intensive care units (ICU) related to challenges in the recruitment process [1] [2] [3] [4] . The legislation and clinical practice vary across the world, and a prior PubMed search did not disclose any resent Scandinavian research covering the overall barriers and challenges in the process of including critically ill patients in clinical studies. The purpose of this study was to identify practical, medical, legal or ethical barriers and challenges in the process of including critically ill patients in the Norwegian Intensive Care Unit Dalteparin Effect (NORIDES) study. The study revealed that most critically ill patients at ICU were unable to provide written, informed consent for study participation. cache = ./cache/cord-026392-cvb44v5v.txt txt = ./txt/cord-026392-cvb44v5v.txt === reduce.pl bib === id = cord-026653-094bk0t0 author = Gülsen, Askin title = Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events* date = 2020-06-24 pages = extension = .txt mime = text/plain words = 14002 sentences = 779 flesch = 47 summary = This review will evaluate reports of allergic and substance-specific infusion reactions (IR), injection-site reactions (ISR), hypersensitivity reactions (HSR), urticaria, and anaphylaxis caused by BSs. The most common indications for the use of biologics in lung diseases are allergic and severe uncontrolled asthma. The Australian Public Assessment report and the FDA label did not observe an increase in the incidence of severe immunological and anaphylactic reactions related to the use of nintedanib [25, 26] . According to the recent BCCA Drug Manual, it was reported that HSR including anaphylaxis can develop in ≤ 1 % (severe < 1 %), IRs in 1 % (severe ≤ 1 %), and immune-mediated rash in 8-18 % ( severe ≤ 1 %) of patients [58] . The FDA's 2019 label reported infusion-related reactions in 11-24 % of patients (placebo 7-18.0 %), acute urticaria in 1-2 %, acute HSRs in 1.5 %, pruritus in 4 %, and serious IRs and anaphylaxis in < 1 % [159] . cache = ./cache/cord-026653-094bk0t0.txt txt = ./txt/cord-026653-094bk0t0.txt === reduce.pl bib === id = cord-025164-hqj22yxe author = Renew, J. Ross title = Neuromuscular blockade management in the critically Ill patient date = 2020-05-24 pages = extension = .txt mime = text/plain words = 8188 sentences = 383 flesch = 31 summary = ACh: Acetylcholine; AMG: Acceleromyography; ARDS: Acute respiratory distress syndrome; ASA: American Society of Anesthesiologists; CIM: Critical illness myopathy; CINM: Critical illness neuromyopathy; CIP: Critical illness polyneuropathy; DVT: Deep venous thrombosis; ED95: Effective dose that decreases the twitch by 95% from baseline; EEG: Electroencephalography; EMG: Electromyography; GRADE: Grading of Recommendations Assessment, Development, and Evaluation; ICP: Intracranial pressure; ICU: Intensive care unit; ICUAW: Intensive care unit-acquired weakness; KMG: Kinemyography; nAChR: Nicotinic acetylcholine receptors; NAP4: 4th National Audit Project; NMBA: Neuromuscular blocking agent; NMJ: Neuromuscular junction; OR: Operating room; OSA: Obstructive sleep apnea; PaO 2 /FiO 2 : Partial pressure of oxygen to fraction of inspired oxygen; pEEG: Processed electroencephalography; PNS: Peripheral nerve stimulator; RSII: Rapid sequence induction and intubation; SCCM: Society of Critical Care Medicine for all aspects of the work. cache = ./cache/cord-025164-hqj22yxe.txt txt = ./txt/cord-025164-hqj22yxe.txt === reduce.pl bib === id = cord-026991-75sbxnsc author = Sultan, Omar Muayad title = Pulmonary ct manifestations of COVID-19: changes within 2 weeks duration from presentation date = 2020-06-17 pages = extension = .txt mime = text/plain words = 2895 sentences = 156 flesch = 55 summary = This retrospective study aims to determine and compare the pulmonary changes in Iraqi patients with COVID-19 disease across the first two weeks after onset of symptoms using computerized tomography (CT) scan. With the continuing COVID-19 pandemic and the increasing number of patients suspected or confirmed with the disease, the radiologists are facing more and more cases because of the paramount role of imaging, particularly chest CT scans in the workup algorithm. In the current study, we compared the pulmonary radiological features associated with COVID-19 infection between two groups of patients, who underwent chest CT scans after different durations from initial clinical presentations. In conclusion, there is a significant difference in the pulmonary manifestations associated with COVID-19 infection when CT scan conducted earlier or later after the clinical presentation, with alteration, on one hand in the proportion and combination of GGO (becoming less) and consolidation (getting more) and, on another hand, more diffuse and multilobar distribution at the second week. cache = ./cache/cord-026991-75sbxnsc.txt txt = ./txt/cord-026991-75sbxnsc.txt === reduce.pl bib === === reduce.pl bib === id = cord-026868-z9gozm2w author = Mohammad, Abeer title = “She’s dead!” – Nursing simulation practices: A discourse analysis approach date = 2020-06-11 pages = extension = .txt mime = text/plain words = 5467 sentences = 245 flesch = 44 summary = This high prevalence of simulation practices in nursing programs has led to opportunities to research this topic from various angles, including its impact on students' skill performance, self-efficacy, self-confidence, self-satisfaction, and clinical knowledge acquisition. Results: The analyses revealed various training and communication issues including the lack of harmony among the team members (e.g., regarding understanding and performing their assigned roles as well as delegating and conducting delegated tasks) and the students' inability to effectively communicate with the patient as a valuable source of information and to make appropriate and timely clinical decisions regarding patient assessment. 2 This widespread use of simulations in nursing programs has led to opportunities to research this topic from many angles, including its impact on students' skill performance, 6, 7 self-efficacy, [8] [9] [10] self-confidence and satisfaction, [11] [12] [13] and, most importantly, clinical knowledge acquisition. cache = ./cache/cord-026868-z9gozm2w.txt txt = ./txt/cord-026868-z9gozm2w.txt === reduce.pl bib === === reduce.pl bib === id = cord-028557-68jypaaw author = Joshi, Jaiteerth R. title = COVSACK: an innovative portable isolated and safe COVID-19 sample collection kiosk with automatic disinfection date = 2020-07-05 pages = extension = .txt mime = text/plain words = 3791 sentences = 186 flesch = 54 summary = The possible reasons for the virus transmission to the healthcare worker could be due to (1) lack of sufficient quantity of personal protective equipment (PPE) at the most infected places; (2) PPE provided not meeting the quality standard requirements; (3) inadequate or unsuitable isolation chambers for testing of suspected patients; and (4) prevailing unhygienic conditions in the facilities where COVID-19 positive patients are treated. The healthcare worker who is standing outside the chamber inserts his hands through the long cuff gloves and collects the sample from either nose or throat of COVID-19 patient. At the deployed hospital, the first prototype COVSACK unit stands to be highly effective in preventing the transmission of COVID-19 virus to healthcare workers during sample collection from suspected persons, due its in-built features such as air tightness, use of long cuff gloves and automatic disinfectant spraying followed by thorough water flushing after each patient exits the kiosk. cache = ./cache/cord-028557-68jypaaw.txt txt = ./txt/cord-028557-68jypaaw.txt === reduce.pl bib === id = cord-027860-s97hdhh6 author = Zeimet, Anthony title = Infectious Diseases date = 2020-06-22 pages = extension = .txt mime = text/plain words = 28925 sentences = 1728 flesch = 45 summary = Although common upper respiratory bacterial pathogens, such as Moraxella (Branhamella) catarrhalis, Streptococcus pneumoniae, and Haemophilus influenzae, may be isolated from patients with acute bronchitis, their relevance is questionable because these bacteria can be present in the respiratory tract of healthy individuals. In the treatment of Bordetella pertussis, early administration of a macrolide antibiotic and patient isolation will likely decrease coughing paroxysms and limit spread of disease (Braman, 2006) (SOR: A). Risk factors for Pseudomonas infection include severe structural lung disease (e.g., bronchiectasis) and recent antibiotic therapy, health care-associated exposures or stay in hospital (especially in the ICU). Patients who present with severe infection or whose infection is progressing despite empiric antibiotic therapy should be treated more aggressively; the treatment strategy should be based on results of appropriate Gram stain, culture, and drug susceptibility analysis. For suspected MRSA skin infections, oral treatment options include trimethoprim-sulfamethoxazole, clindamycin, and doxycycline of purulent material when performing incision and drainage in the event that the patient fails to improve and antibiotic coverage becomes necessary. cache = ./cache/cord-027860-s97hdhh6.txt txt = ./txt/cord-027860-s97hdhh6.txt === reduce.pl bib === === reduce.pl bib === id = cord-027259-f4sgobcz author = Metsker, Oleg title = Stroke ICU Patient Mortality Day Prediction date = 2020-05-23 pages = extension = .txt mime = text/plain words = 5328 sentences = 204 flesch = 42 summary = On the basis of the analysis of 12 modern prognostic models from 10 countries we can identify some of the most stable (main) predictors for the causes of intra-hospital mortality: age [16, [20] [21] [22] [23] [24] ; type of stroke [25] ; lesion location [25] ; level of consciousness [11, 20, 23, 25, 26] upon admission; NIHSS stroke severity [10, 21, 22, 24] ; comorbidity [22, 27] , Charlson comorbidity index [23] , Atrial fibrillation [11, 22] , case history Transitor ischemic attack (TIA) [31]; hospital complications (high intracranial pressure) [16] , pneumonia, seizures, anxiety/depression, infections, limb pains and constipation [22, 27] . Early mortality in each subgroup was associated with a number of demographic, clinical, and instrumental-laboratory characteristics based on the interpretation of the results of calculating the significance of predictors of binary classification models by machine learning methods from the Scikit-Learn library 2 . cache = ./cache/cord-027259-f4sgobcz.txt txt = ./txt/cord-027259-f4sgobcz.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-028907-m9psxg1f author = Li, Yi title = Extended antiplatelet therapy with clopidogrel alone versus clopidogrel plus aspirin after completion of 9- to 12-month dual antiplatelet therapy for ACS patients with both high bleeding and ischemic risk. Rationale and design of the OPT-BIRISK double blinded, placebo controlled randomized trial date = 2020-07-09 pages = extension = .txt mime = text/plain words = 3535 sentences = 165 flesch = 42 summary = BACKGROUND: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is the cornerstone for prevention ischemic events in patients with acute coronary syndromes (ACS) and undergoing percutaneous coronary intervention (PCI). J o u r n a l P r e -p r o o f 3 / 21 Background Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is the cornerstone to prevent stent thrombosis and atherothrombotic events in patients with acute coronary syndromes (ACS) and/or undergoing percutaneous coronary intervention (PCI) [1] [2] [3] . In order to test this hypothesis, we designed the Optimal antiPlatelet Therapy for high Bleeding and Ischemic RISK patients (OPT-BIRISK) trial, to determine if extended clopidogrel monotherapy will be superior to DAPT with clopidogrel and aspirin following completion of 9 to 12 months DAPT for ACS patients who received drug eluting stent (DES) implantation and possess both high bleeding and high ischemic characteristics. cache = ./cache/cord-028907-m9psxg1f.txt txt = ./txt/cord-028907-m9psxg1f.txt === reduce.pl bib === id = cord-028285-n4dommet author = Weilongorska, Natasha L. title = COVID-19: What are the challenges for NHS surgery? date = 2020-07-02 pages = extension = .txt mime = text/plain words = 9755 sentences = 619 flesch = 46 summary = With there being a short interval from the time of the first COVID-19 case presentation, to the development of a global pandemic, validated management algorithms to support changes in operative strategies are lacking. The key components of NHS preoperative patient screening for COVID-19 are: structured questionnaires with temperature monitoring, viral real-time polymerase chain reaction (RT PCR) for SARS-CoV-2, and chest imaging. Full PPE (fluid resistant gown, double gloving, visor or goggles, fit-tested FFP3 mask or respirator, disposable hat, shoe covers) should be worn in the operating rooms for any suspected or positive COVID-19 case, for AGP 38 (Table 3) , and for procedures for which the risk is unknown. All surgical cases require a discussion about the patient's COVID-19 status, the degree of aerosol risk for each part of the procedure (induction of anaesthesia, extubation, and for all operative phases), with PPE requirement stated for each stage. cache = ./cache/cord-028285-n4dommet.txt txt = ./txt/cord-028285-n4dommet.txt === reduce.pl bib === id = cord-027677-fc410vto author = GOULD, JANE M. title = Pharyngitis, Stomatitis, Peritonsillar, and Retropharyngeal Abscess date = 2020-06-22 pages = extension = .txt mime = text/plain words = 6196 sentences = 365 flesch = 47 summary = Acute retroviral syndrome, a manifestation of acute HIV infection, typically has an incubation period that ranges from 3 to 5 weeks with symptoms that include fever, nonexudative pharyngitis, lymphadenopathy, arthralgia, myalgia, and lethargy. haemolyticum pharyngitis include peritonsillar abscess (PTA) similar to that of GA␤HS infection (see later). Periodic fever associated with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) typically occurs in patients younger than 5 years of age. GA␤HS requires antimicrobial therapy in order to prevent the development of acute rheumatic fever (ARF) and to reduce the risk of suppurative complications such as PTA, retropharyngeal abscess, cervical adenitis, sinusitis, mastoiditis, otitis media, and bacteremia leading to metastatic infection. It usually occurs in older school-age children, adolescents, and young adults as a complication of recurrent bacterial tonsillitis or a secondary bacterial infection following viral pharyngitis. cache = ./cache/cord-027677-fc410vto.txt txt = ./txt/cord-027677-fc410vto.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-022633-fr55uod6 author = nan title = SAEM Abstracts, Plenary Session date = 2012-04-26 pages = extension = .txt mime = text/plain words = 147405 sentences = 8927 flesch = 54 summary = Staff satisfaction was evaluated through pre/ post-shift and study surveys; administrative data (physician initial assessment (PIA), length of stay (LOS), patients leaving without being seen (LWBS) and against medical advice [LAMA] ) were collected from an electronic, real-time ED information system. Communication Background: The link between extended shift lengths, sleepiness, and occupational injury or illness has been shown, in other health care populations, to be an important and preventable public health concern but heretofore has not been fully described in emergency medical services (EMS Objectives: To assess the effect of an ED-based computer screening and referral intervention for IPV victims and to determine what characteristics resulted in a positive change in their safety. Objectives: Using data from longitudinal surveys by the American Board of Emergency Medicine, the primary objective of this study was to evaluate if resident self-assessments of performance in required competencies improve over the course of graduate medical training and in the years following. cache = ./cache/cord-022633-fr55uod6.txt txt = ./txt/cord-022633-fr55uod6.txt === reduce.pl bib === id = cord-028590-rw0okd0p author = Westgarth, David title = What does the future hold for the workforce of tomorrow? date = 2020-07-06 pages = extension = .txt mime = text/plain words = 4657 sentences = 222 flesch = 62 summary = 'Many hospitals have had to adapt to become urgent dental care hubs during the peak of the pandemic, with both the hospitals I work in beginning to start to resume some ' According to a new poll by the mental health charity Mind, many people who were previously well will develop mental health problems as a 'direct consequence of the pandemic and all that follows', with the worst yet to come.' routine services. ' As always, the impact will be greatest on the most vulnerable of the profession: new graduates, many of whom have lost their part-time jobs; young dentists leaving dental foundation training and potentially struggling to find their first associateship; and dental care professional colleagues who are significantly affected by the closure of practices and the expected lengthy return to the provision of dentistry over the coming months. cache = ./cache/cord-028590-rw0okd0p.txt txt = ./txt/cord-028590-rw0okd0p.txt === reduce.pl bib === === reduce.pl bib === id = cord-015354-yknwveyz author = nan title = Abstracts_Poster presentations date = 2007-09-18 pages = extension = .txt mime = text/plain words = 221428 sentences = 13119 flesch = 54 summary = Material and Methods: Fourteen individuals (mean age 47±19y range 21-75y; 4W, 10M; including 10 volunteers and 4 patients with angiographically proved CAD) underwent dynamic PET imaging studies (21 frames) at rest and during adenosine stress (0.14mg/kg/min for 6 min) after injection of 1100MBq of 82Rb (Discovery LS, GEMS). Methods:Twenty-nine patients (21 males,8 females;62±11 yrs) with recent AMI were studied.Within 6 days after AMI, the patients were performed Tl-201 R-RD perfusion SPECT using 4 mCi activity.CMR was carried out 5-20 minutes after 0,15 mmol/kg of iv.Gadobutrol injection.Myocardial perfusion and contrast enhancement was analyzed using a 17 segment model.Myocardial perfusion was scored in Tl-201 SPECT as follows:0=normal (70%-100% maximal myocardial activity(mma), 1= 69-50% mma, 2= 49-30% mma ,3=29-10% mma and 4=<10% mma ;Myocardial contrast enhancement on CMR images was graded as:0=no contrast enhancement, 1=hyperenhancement of 0-25% of the wall thickness(WT) 2=hyperenhancement of 26-50 % of the WT, 3=hyperenhancement of 51-75 % of WT and 4=hyperenhancement of 76-100 % of WT.In CMR the existence of microvascular obstruction(MO) was also evaluated.Total segment scores(TSS) in R,RD and CMR for each patient were calculated by summing of 17 segment score values. cache = ./cache/cord-015354-yknwveyz.txt txt = ./txt/cord-015354-yknwveyz.txt === reduce.pl bib === id = cord-029211-6o7qn2y2 author = nan title = Press review date = 2020-07-15 pages = extension = .txt mime = text/plain words = 6197 sentences = 368 flesch = 52 summary = In this study, we aimed to report the 5-year oncological outcomes, including local recurrence, metastatic disease, and survival. Patients age 18 years and older with T2T3 low rectal cancer, of maximum size 4 cm, who were clinically good responders after chemoradiotherapy (residual tumour ≤ 2 cm) were randomly assigned before surgery to either local excision or total mesorectal excision. The primary objective of this study was to assess the 5-year oncological outcomes of local recurrence, metastatic disease, disease-free survival, overall survival, and cancer-specific mortality, which were the secondary endpoints of GRECCAR 2. After 2 years, overall and disease-free survival tended to be improved in simultaneous as compared with delayed-resection groups (P 0.05), a tendency which persisted for OS after a median follow-up of 47 months. This retrospective monocenter study analyzed the shortand long-term outcomes of pancreatectomies associated with arterial resection for patients with either borderline (27%) or locally advanced (73%) pancreatic adenocarcinoma. cache = ./cache/cord-029211-6o7qn2y2.txt txt = ./txt/cord-029211-6o7qn2y2.txt === reduce.pl bib === id = cord-029466-9sy6icrm author = Ramadan, Ahmad Riad title = Tales of a department: how the COVID-19 pandemic transformed Detroit’s Henry Ford Hospital, Department of Neurology—part I: the surge date = 2020-07-12 pages = extension = .txt mime = text/plain words = 4345 sentences = 205 flesch = 49 summary = In the first 2 weeks, the meetings were focused on ensuring the availability of personal protective equipment (PPE), the shutting down of all neurology outpatient and most inpatient activities, establishment of virtual care activity and seeking volunteers for redeployment openings listed by Incident Command on the daily leadership calls. In order to expand the number of ICU beds, the larger unit, consisting of 18 beds, became an extension of the medical ICU (MICU) for patients with confirmed or suspected COVID-19 and was staffed by internal medicine (IM) physicians and residents. Neurological checks and National Institutes of Health Stroke Scale assessments were performed using video devices to limit exposure to HCPs. Consensus was reached between the stroke team, neurointerventional team and radiology on an amended policy to manage patients receiving thrombectomy during the pandemic. Several neurology residents were redeployed to provide care for patients admitted to the COVID-19 unit under the supervision of an IM staff. cache = ./cache/cord-029466-9sy6icrm.txt txt = ./txt/cord-029466-9sy6icrm.txt === reduce.pl bib === id = cord-029606-2z1tw4xo author = John, Janice title = Developing an Intensive Community Covid-19 Management Strategy: Helping Our Patients Access Patient-Centered Care across a Continuum of Covid-19 Disease Needs date = 2020-05-27 pages = extension = .txt mime = text/plain words = 3161 sentences = 165 flesch = 49 summary = An intensive community management strategy, including outreach to high-risk patients, dedicated telephone triage, and a respiratory clinic, can reduce hospitalizations and improve outcomes for Covid-19. Our model spans the continuum of care and includes six key components: high-risk outreach, telephonic primary care, a phone triage system, a community management group, a respiratory clinic, and integrated emergency room/hospital care ( Figure 1 ). The triage center is a dedicated group of nurses supported by onsite physicians who (1) determine whether patients' symptoms are clinically consistent with Covid-19 using a symptom checklist, (2) risk-stratify patients for severe disease complications using risk stratification criteria (Table 1) (3) determine whether patients meet criteria for testing, (4) conduct robust education (about 10-15 min) on home care with attention to self-isolation and selfquarantine and (5) evaluate patients for symptoms requiring urgent in-person assessment at the respiratory clinic based on identification of potential pulmonary involvement. cache = ./cache/cord-029606-2z1tw4xo.txt txt = ./txt/cord-029606-2z1tw4xo.txt === reduce.pl bib === id = cord-029112-u507i0t0 author = Smith, Keisha title = A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date = 2020-07-13 pages = extension = .txt mime = text/plain words = 20880 sentences = 1243 flesch = 46 summary = Study ALXN1210-COV-305 is a multicenter Phase 3, open-label, randomized, controlled study designed to evaluate the safety and efficacy of intravenous (IV) ravulizumab + best supportive care (BSC), compared with BSC alone in patients with a confirmed diagnosis of SARS-CoV-2 infection, and a clinical presentation consistent with COVID-19 severe pneumonia, acute lung injury, or ARDS. cache = ./cache/cord-029112-u507i0t0.txt txt = ./txt/cord-029112-u507i0t0.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-021206-4zyqqgs0 author = nan title = Scientific and Educational Exhibits date = 2007 pages = extension = .txt mime = text/plain words = 138669 sentences = 8591 flesch = 48 summary = Purpose: To analyze the clinical and imaging fi ndings of BI-RADS category 3 breast lesions by mammographic and ultrasonographic (US) assessment ultimately diagnosed as malignancy in retrospect Methods and Materials: Of 3,207 cases of US-guided core needle biopsy for 4 years, category 3 was given after biopsy, based on mammographic and sonographic evaluation, in 1,099 lesions (41.7%) that were composed of 462 palpable and 637 nonpalpable lesions. Background: Regional kinesis alteration of IVS is associated with different cardiac conditions which may have both pathological and physiological meanings of which the most important are the following: a) left bundle branch block that may determine intra-left ventricular asynchrony and may represent an independent predictor of severe cardiac events in heart failure patients; b) pulmonary embolism that increase right ventricle pressure; c) constrictive pericarditis; d) restrictive cardiomyopathies; e) post-operative cardiac surgery. cache = ./cache/cord-021206-4zyqqgs0.txt txt = ./txt/cord-021206-4zyqqgs0.txt === reduce.pl bib === id = cord-029615-x498xj3m author = Kim, Michelle Kang title = A Primer for Clinician Deployment to the Medicine Floors from an Epicenter of Covid-19 date = 2020-05-04 pages = extension = .txt mime = text/plain words = 2914 sentences = 133 flesch = 44 summary = The first step in effective deployment was for the Department of Medicine (DOM) Chair to name the decision makers and establish a command structure with formalized roles and responsibilities.1 Anticipated responsibilities were divided and delegated based upon those individuals' strengths and networks.2 DOM Vice Chairs were delegated specific responsibilities related to the build-out of the inpatient service (Table 1) , which required full-time commitment and temporary suspension of all non-Covid research and clinical activities. Additional DOM vice chairs coordinated personal protective equipment (PPE) needs with hospital administration, provided education regarding PPE use, onboarded outpatient physicians and facilitated their inpatient electronic medical record (EMR) access and training, and created teaching modules on treatment of the acutely ill Covid patient. In addition, volunteers and locum tenens providers were rapidly onboarded and integrated into teams and schedules.13 All remaining medicine divisions and other departments were asked to identify nurse practitioners (NPs), physician assistants (PAs), residents, and fellows eligible for deployment to the surge medical teams. cache = ./cache/cord-029615-x498xj3m.txt txt = ./txt/cord-029615-x498xj3m.txt === reduce.pl bib === id = cord-029848-dj5xqlz1 author = Mahajan, Vidushi title = Using Telemedicine During the COVID-19 Pandemic date = 2020-05-14 pages = extension = .txt mime = text/plain words = 2134 sentences = 122 flesch = 49 summary = Telemedicine is defined as the delivery of health care services, where distance is a critical factor, by all healthcare professionals using information or communication technology. Telemedicine aims to ensure equitable services to everyone, is costeffective, provides safety to both patient and doctors during pandemics, and offers timely and faster care. Telemedicine can be classified on the basis of mode of communication as (i) audio, video or text-based (video mode is preferred as it allows limited examination as well); (ii) timing of information transmitted as real time or asynchronous exchange; (iii) purpose of consult as first time or follow up (in non-emergent cases or emergency consultation); and (iv) according to individuals involved as patient to medical practitioner, caregiver to medical practitioner, medical practitioner to medical practitioner or health worker to medical practitioner [2] . Doctors should avoid giving advice in such cases and the patient must be referred for an urgent in-person visit to the nearest hospital. cache = ./cache/cord-029848-dj5xqlz1.txt txt = ./txt/cord-029848-dj5xqlz1.txt === reduce.pl bib === id = cord-022650-phsr10jp author = nan title = Abstracts TPS date = 2018-08-14 pages = extension = .txt mime = text/plain words = 119675 sentences = 7010 flesch = 55 summary = 0685 | Skin prick test reactivity to aeroallergens in adult allergy clinic in a tertiary hospital: a 12-year retrospective study Results: Five different human sera were screened for specific IgE level against 29 different allergen sources using test methods of three different suppliers. Conclusion: This multicenter prospective study confirmed that stepwise single-dose OFC to egg will help to clarify the severity of egg allergy, and will contribute to improved food allergy manageMethod: The study design was a retrospective cohort study extracting data from the electronic chart of children older than 4 years who visited our out-patient clinic for egg or milk allergy and who underwent an oral food challenge test (OFC) twice within 24 months between November 2013 and December 2017. Results: In the base case analysis, using Italy clinical practice patients with moderate-to severe allergic rhino-conjunctivitis (SS ranging from 6 to 15 points) and a mean age at entry of 21 years, both SCIT and SLIT were associated with increased cost but superior efficacy compared to pharmacotherapy alone. cache = ./cache/cord-022650-phsr10jp.txt txt = ./txt/cord-022650-phsr10jp.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-023592-w96h4rir author = nan title = Abstracts cont. date = 2015-12-28 pages = extension = .txt mime = text/plain words = 67857 sentences = 4136 flesch = 52 summary = Conclusions: Although the risk of developing more serious gastric lesions increased as the number of virulence factor genes are accumulated in a given Hp strain, we did not find any significant differences or relationship in the cagA, vacA or babA2 status between the Hp isolates from patients with gastritis or peptic ulcer in this study. pneumophila at the serogroup level, it was used in two different outbreaks to demonstrate rapidly the identity of the sequences between strains responsible for severe human infection and those isolated in the hot water reservoir, suggesting a common origin. To determine the antimicrobial resistance in Salmonella and Shigella strains isolated from stool specimens during a 2-year period, from patients admitted to our clinics with a diagnosis of diarrhoea. In our study the susceptibility of 65 bacterial strains isolated in hospital environment (colonising or infecting patients or carried by German cockroaches) to antibiotics and chemical disinfectants was determined. cache = ./cache/cord-023592-w96h4rir.txt txt = ./txt/cord-023592-w96h4rir.txt === reduce.pl bib === id = cord-022501-9wnmdvg5 author = nan title = P1460 – P1884 date = 2015-12-28 pages = extension = .txt mime = text/plain words = 128256 sentences = 7808 flesch = 51 summary = Methods: Using published data on (1) the prevalence of MRSA and other bacterial pathogens causing cSSSI in the US, (2) the in-vitro susceptibility rates of commonly used regimens in cSSSI in the US in relation to the most pervasive pathogens identified above, and (3) estimated costs of failure of initial, empiric treatment from a recent study of a large US multi-hospital database, we developed a model to predict the expected clinical and economic impact of increasing prevalence of MRSA. Small outbreaks of VEB-1 ESBL producing Acinetobacter baumannii in Belgian nursing homes and hospitals through cross-border transfer of patients from northern France Methods: From 01/04 to 03/05, all Belgian acute hospitals were invited to report cases of nosocomial infections/colonisations due to MDR Ab isolates presenting a resistance profile similar to the French epidemic strain (resistance to all agents except carbapenems and colistin) and to send such isolates to the reference laboratory for phenotypic confirmation and for genotypic characterization (PCR of VEB-1 and class 1 Integron, PFGE typing). cache = ./cache/cord-022501-9wnmdvg5.txt txt = ./txt/cord-022501-9wnmdvg5.txt === reduce.pl bib === id = cord-030256-muah207b author = Kapoor, Poonam Malhotra title = COVID-19 Thrombosis: An Unsolved Mystery date = 2020-07-24 pages = extension = .txt mime = text/plain words = 1649 sentences = 92 flesch = 49 summary = The marked elevation of IL-6 in patients with cytokine release syndrome (CRS) led to the institution of successful targeted therapy for the treatment of CRS using IL-6 receptor blockade (tocilizumab). It is widely acknowledged that the majority of COVID-19 patients, especially those with severe disease, are characterized by lymphocytopenia. Where extracorporeal life support (ECLS) expertise is available, it should be considered according to the standard management algorithm for ARDS in supporting patients with viral lower respiratory tract infection. Although there are no published outcomes, early experience in Wuhan, China, indicates that prone position was widely used in patients with COVID-19 related severe ARDS and had possible benefits. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study United States Center for Disease Control interim guidance for clinical management of COVID-19 patients with and without acute respiratory distress syndrome cache = ./cache/cord-030256-muah207b.txt txt = ./txt/cord-030256-muah207b.txt === reduce.pl bib === id = cord-029991-0sy417j0 author = Longhini, Federico title = Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study date = 2020-08-03 pages = extension = .txt mime = text/plain words = 4621 sentences = 239 flesch = 39 summary = BACKGROUND: Besides airway suctioning, patients undergoing invasive mechanical ventilation (iMV) benefit of different combinations of chest physiotherapy techniques, to improve mucus removal. The presence of an endotracheal tube impairs the bronchial mucus velocity transport in anaesthetized dogs [2] ; in critically ill patients undergoing invasive mechanical ventilation (iMV), it seriously impairs cough reflex and mucociliary escalator function [3, 4] , promoting the accumulation of tracheobronchial secretions, leading to sequestration and densification of secretions in the lower airways and increasing the risk of pneumonia [5] and lung atelectasis [6] . The aim of this pilot randomized physiological study is assessing the effects of HFCWO on lung aeration and ventilation distribution, as assessed by EIT, in normosecretive and hypersecretive mechanically ventilated patients. Our study shows that chest physiotherapy by HFCWO may improve lung aeration of hypersecretive mechanically ventilated patients, without affecting gas exchange. cache = ./cache/cord-029991-0sy417j0.txt txt = ./txt/cord-029991-0sy417j0.txt === reduce.pl bib === id = cord-030254-eevqclsy author = Mehta, Chitra title = Management of Coronavirus 2019 date = 2020-04-24 pages = extension = .txt mime = text/plain words = 4032 sentences = 287 flesch = 56 summary = A suspected case has been defined as a patient with acute onset respiratory infection with fever, cough, sore throat, and an epidemiological link in the form of a history of travel 14 days prior to the onset of symptoms to countries afflicted with COVID-19, or a close contact with a confirmed or probable case of COVID-19 14 days prior to symptom onset, or some acute respiratory infection requiring hospitalization with no other etiology fully explaining the clinical presentation, as per WHO guidelines. • In patients with severe COVID-19 infection requiring supplemental oxygen, lopinavir/ritonavir combination plus hydroxychloroquine plus favipiravir 1,600 mg (eight tablets) twice daily as a loading dose followed by 600 mg (three tablets) every 8 hours for 14 days is being used. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical management of severe acute respiratory infection when COVID-19 disease is suspected. cache = ./cache/cord-030254-eevqclsy.txt txt = ./txt/cord-030254-eevqclsy.txt === reduce.pl bib === id = cord-031130-xvkyt3l3 author = Moreno-Duarte, Ingrid title = Heparin Induced Thrombocytopenia for the Perioperative and Critical Care Clinician date = 2020-08-29 pages = extension = .txt mime = text/plain words = 6021 sentences = 317 flesch = 34 summary = RECENT FINDINGS: Heparin-induced thrombocytopenia (HIT) occurs more frequently in surgical patients compared with medical patients due to the inflammatory release of platelet factor 4 and perioperative heparin exposure. Heparinoid exposure by syringe flush, subcutaneous prophylaxis, or therapeutic anticoagulation is common in the operative room (OR) and ICU environments [5] .Only a fraction of those with low platelet counts will develop HIT, which presents in approximately 0.3-0.5% of critically ill patients exposed to heparin [6] . Although HIT is less frequent in cardiac surgical patients compared with orthopedic patients, cardiac surgical patients have a higher frequency of HIT immunization (positive antibody formation) [15] , potentially due to the high intraoperative UFH doses required for anticoagulation on cardiopulmonary bypass [7, 17] . Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells cache = ./cache/cord-031130-xvkyt3l3.txt txt = ./txt/cord-031130-xvkyt3l3.txt === reduce.pl bib === id = cord-010092-uftc8inx author = nan title = Abstract of 29th Regional Congress of the ISBT date = 2019-06-07 pages = extension = .txt mime = text/plain words = 233304 sentences = 13171 flesch = 54 summary = Prospective testing of blood donations in endemic areas of the U.S. revealed 0.38% of donors were positive for Babesia DNA or antibodies (Moritz, NEJM, 2016) Aims: -To report results of ongoing Babesia clinical trial -To explain significance of Babesia as a TT infection Methods: In cobas â Babesia for use on the cobas â 6800/8800 Systems, is a qualitative polymerase chain reaction nucleic acid amplification test, developed to detect in whole blood (WB) donor samples the 4 Babesia species that cause human disease: B. In sensitivity analyses, there were two discrepant results for HIV testing, three for HCV, and five for anti-HBc. Summary/Conclusions: Elecsys â infectious disease parameters on the cobas e 801 analyser demonstrate high specificity/sensitivity for screening first-time blood donor samples, with similar clinical performance to other commercially available assays. cache = ./cache/cord-010092-uftc8inx.txt txt = ./txt/cord-010092-uftc8inx.txt === reduce.pl bib === === reduce.pl bib === id = cord-026031-hnf5vayd author = Ford, Richard B. title = Emergency Care date = 2009-05-21 pages = extension = .txt mime = text/plain words = 112343 sentences = 6645 flesch = 44 summary = Fresh whole blood Coagulopathy with active hemorrhage (disseminated intravascular coagulation, thrombocytopenia; massive acute hemorrhage; no stored blood available) Stored whole blood Massive acute or ongoing hemorrhage; hypovolemic shock caused by hemorrhage that is unresponsive to conventional crystalloid and colloid fluid therapy; unavailability of equipment required to prepare blood components Packed red blood cells Nonregenerative anemia, immune-mediated hemolytic anemia, correction of anemia before surgery, acute or chronic blood loss Fresh frozen plasma Factor depletion associated with active hemorrhage (congenital: von Willebrand's factor, hemophilia A, hemophilia B; acquired: vitamin K antagonist, rodenticide intoxication, DIC); acute or chronic hypoproteinemia (burns, wound exudates, body cavity effusion; hepatic, renal, or gastrointestinal loss); colostrum replacement in neonates Frozen plasma Acute plasma or protein loss; chronic hypoproteinemia; (contains stable colostrum replacement in neonates; hemophilia B and clotting factors) selected clotting factor deficiencies Platelet-rich plasma* Thrombocytopenia with active hemorrhage (immune-mediated thrombocytopenia, DIC); platelet function abnormality (congenital: thrombasthenia in Bassett hounds; acquired: NSAIDs, other drugs) Cryoprecipitate cache = ./cache/cord-026031-hnf5vayd.txt txt = ./txt/cord-026031-hnf5vayd.txt === reduce.pl bib === id = cord-028721-x6f26ahr author = Nistal, Manuel title = Non-neoplastic diseases of the testis date = 2020-06-22 pages = extension = .txt mime = text/plain words = 78172 sentences = 5138 flesch = 41 summary = Congenital decrease of germ cells occurs in numerous conditions, including trisomies 13, 18, and 21, some forms of primary hypogonadism such as Klinefelter's syndrome, anencephaly, many cryptorchid testes, and in patients with posterior urethral valves and severe obstruction of the urinary ducts. 728, 729 Leydig cell hypoplasia This variant of male pseudohermaphroditism is defi ned by insuffi cient testosterone secretion 422 and the following characteristics: predominance of female external genitalia; absence of male secondary sex characteristics at puberty; absence of uterus and fallopian tubes and the presence of epididymis and vas deferens; 46XY karyotype; lack of response to human chorionic gonadotropin stimulation; absence of an enzymatic defect in testosterone synthesis; and small undescended testes that are gray and mucous on section. cache = ./cache/cord-028721-x6f26ahr.txt txt = ./txt/cord-028721-x6f26ahr.txt === reduce.pl bib === id = cord-031544-clzt6kyg author = Clavijo, Raul title = “Online” and “at-home” versus traditional models of health care: enhancing access or impeding optimal therapeutics? date = 2020-09-08 pages = extension = .txt mime = text/plain words = 4303 sentences = 209 flesch = 38 summary = Thus, owing to the lack of physical exposure to clinical settings, it is likely that our patients with sexual dysfunction, with or without infertility, who stand to benefit the most from our taking a potential risk of prescribing medications after virtual care. Overall, the availability of prescription medications with well-defined risk profiles to patients through virtual sources is only likely to enhance the access to care for sexual and reproductive health conditions by easing the pain of embarrassment some patients may experience. In light of the current situation of the COVID pandemic along with the boom of telemedicine, physicians should consider incorporating home-based kits for both male and female fertility testing with the caveats that even though we may not get accurate data all the time, data from these kits can be used to guide care. Although physical examination and in-office diagnostics are paramount for the evaluation of both female and male fertility, an initial telehealth visit can uncover pertinent history, identify risk factors, and establish the physician-patient relationship. cache = ./cache/cord-031544-clzt6kyg.txt txt = ./txt/cord-031544-clzt6kyg.txt === reduce.pl bib === === reduce.pl bib === id = cord-029884-zl0uqmfi author = Horowitz, Robert K. title = MVP (Medical situation, Values and Plan): A memorable and useful model for all Serious Illness Conversations date = 2020-07-30 pages = extension = .txt mime = text/plain words = 3481 sentences = 260 flesch = 61 summary = This step explores the patient's beliefs, goals, ideology, narrative, hopes, fears, and communication, informational and decision-making preferences in the context of the now-understood medical situation. An effective SIC requires the clinician to honor patient and family autonomy and personhood by: ensuring their assent to answer questions and receive information; tailoring that information to their needs, abilities, and preferences, as well as the situational urgency; valuing and learning their history and experience; informing them to the extent possible, reasonable and desired; and ensuring their centrality to the shared decision-making process. â�¢I admire your courage in discussing this hard stuff.â�¢Now that I understand your values, I'd like to offer a recommendation, okay?â�¢If your breathing deteriorates I suggest weâ�¦ (ex.,take resuscitation off the table, and treat your symptoms at homeâ�¦ORâ�¦offer a time-limited ventilator trialâ�¦ORâ�¦)â�¢Does this make sense? cache = ./cache/cord-029884-zl0uqmfi.txt txt = ./txt/cord-029884-zl0uqmfi.txt === reduce.pl bib === id = cord-029150-e242o2ml author = Du, Jiang title = Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic date = 2020-07-08 pages = extension = .txt mime = text/plain words = 4256 sentences = 187 flesch = 32 summary = In early 2020, the COVID-19 outbreak complicated the diagnosis, treatment and rehabilitation of patients with substance use disorders and increased the risks of substance abuse and addictive behaviours, such as online gaming disorders, in the general public. It also adversely impacts the mental state of the general public in several ways and leads to broader symptoms, including anxiety, tension and insomnia, that may increase the risk of alcohol abuse, sedative and hypnotic drug abuse, and other addictive behaviours. 2 3 It is also of utmost importance to ensure the continuous, regular and effective treatment of existing patients with addiction problems, reduce the risk of drug relapse and prevent new cases of addiction during the pandemic. The screening of addictive substance use, prevention and education for clinic patients, as well as the timely identification, diagnosis and treatment of related mental and behavioural problems may all occur under stressful conditions. cache = ./cache/cord-029150-e242o2ml.txt txt = ./txt/cord-029150-e242o2ml.txt === reduce.pl bib === id = cord-021087-n4epxwn9 author = nan title = ECR – Final Programme: Scientific and Educational Exhibits date = 2004 pages = extension = .txt mime = text/plain words = 154170 sentences = 9372 flesch = 48 summary = Conclusions: MRI is useful to identify tumor response to Imatinib Mesylate in advanced GIST as from the early months of therapy with the following indicators of treatment activity: A) Size of lesions; B) signal intensity; C) vascularization; D) amount of degenerative tissue or necrosis; E) presence of peritoneal fluid. Materials and Methods: 34 patients (13 female, 21 male) from two centres with proven myocardial infarction by ECG, clinical and echo criteria underwent stress/ rest Tc99 sestamibi Gated SPECT scanning with a dual headed gamma camera and late contract enhanced MRI on identical 1.5 Tesla scanners in each centre using a protocol which imaged 15 minutes after injection of 0.1 mmol/kg IV gadolinium. These preliminary results illustrate the ability of MRI to assess the integrity of the TFCC and suggests its use as the first imaging method following plain radiography in the evaluation of patients with chronic posttraumatic pain on the ulnar side of the wrist. cache = ./cache/cord-021087-n4epxwn9.txt txt = ./txt/cord-021087-n4epxwn9.txt === reduce.pl bib === id = cord-030370-89n13hml author = Brown, Colin S. title = Ebola Virus Disease in the Obstetric Population date = 2019-04-11 pages = extension = .txt mime = text/plain words = 17486 sentences = 770 flesch = 47 summary = Epidemiological factors Considerations for screening for general populations Early: fever, profound weakness or malaise, headache, myalgia, arthralgia, conjunctivitis, nausea or anorexia, throat pain or difficulty swallowing, abdominal or epigastric pain, diarrhea (bloody or nonbloody) Exposure/Contact: infected animals, bushmeat or fruit also fed on by bats, healthcare workers/ traditional healers also treating EVD, items soiled or touched by positive EVD patient, deceased EVD bodies Sexual intercourse with EVD-positive male or EVD survivor Late: confusion and irritability, hiccups, seizures, chest pain, diarrhea (watery or bloody), vomiting (with or without blood), skin rash, internal or external bleeding, shock, respiratory distress Additional considerations for screening obstetric population Vaginal bleeding of unknown origin, spontaneous abortion, premature labor and/or rupture of membranes, preterm labor, antepartum and postpartum hemorrhage, intrauterine fetal demise, stillbirth, loss of consciousness Exposure to products of conception or deceased fetus of EVD positive patient Being a pregnant woman with history of contact with confirmed EVD patient, recent EVD survivor with an intact pregnancy, newborn of an EVD positive mother, infant breastfed by a recent EVD positive mother WHO Library Cataloguing-in-Publication Data [55] setting, women were often left untreated or were provided minimal intervention by frightened medical staff working in an overwhelmed, under resourced health care system in crisis. cache = ./cache/cord-030370-89n13hml.txt txt = ./txt/cord-030370-89n13hml.txt === reduce.pl bib === id = cord-030918-0w327dgj author = Praena Crespo, Manuel title = Patient-centered primary care pediatrics. Is a paradigm change needed?() date = 2020-08-27 pages = extension = .txt mime = text/plain words = 1315 sentences = 56 flesch = 49 summary = At present, the functional organization of paediatric care in PCTs includes health prevention and promotion activities through healthy child (HC) and school-based health programmes, on-demand visits for management of acute diseases, scheduled appointments for follow-up of chronic diseases and coordination of care delivery by different providers: nurses, midwives, dentists, physical therapists, psychologists, social workers and family physicians. Another high-priority organizational change is the participation of paediatric nurses in the care of the paediatric population, both in the form of on-demand nursing visits for follow-up of patients with acute diseases and, especially, the management of patients with SHCNs through scheduled nursing visits for health education and follow-up of patients with asthma, obesity, diabetes and other chronic diseases requiring nursing care and healthy child programme services. cache = ./cache/cord-030918-0w327dgj.txt txt = ./txt/cord-030918-0w327dgj.txt === reduce.pl bib === id = cord-030531-4uucx9ss author = Randremanana, Rindra Vatosoa title = An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial date = 2020-08-17 pages = extension = .txt mime = text/plain words = 8049 sentences = 388 flesch = 50 summary = All drugs in use for treating plague are registered based on experimental data and anecdotal evidence, and no regimen currently recommended is supported by a randomized clinical trial. The primary endpoint of the trial is to assess the proportion of patients with bubonic plague who have a therapeutic response to treatment (defined as alive, resolution of fever, 25% reduction in the size of measurable buboes, has not received an alternative treatment and no clinical decision to continue antibiotics) as assessed on day 11. The secondary objective is to collect data on the effectiveness of ciprofloxacin in the treatment of pneumonic plague, although the trial is not able to formally assess the non-inferiority of ciprofloxacin monotherapy compared to streptomycin and ciprofloxacin combination therapy in pneumonic plague, Considering the operational and practical complexities of a plague RCT, the study also has additional exploratory objectives to optimize investments: to evaluate the level and kinetics of anti-Y. cache = ./cache/cord-030531-4uucx9ss.txt txt = ./txt/cord-030531-4uucx9ss.txt === reduce.pl bib === id = cord-030502-mvlib8ol author = Hatachi, Takeshi title = Early steroid pulse therapy among children with influenza virus-associated encephalopathy date = 2020-08-12 pages = extension = .txt mime = text/plain words = 4265 sentences = 222 flesch = 44 summary = CONCLUSIONS: We did not observe the effectiveness of early steroid pulse therapy on patient outcomes among children with IAE in our study population including all clinical subtypes of IAE. In this study, we aimed to assess the effectiveness of early steroid pulse therapy on patient outcomes among children with all subtypes of IAE using a nationwide database in Japan. We observed no significant difference in patient outcomes between the propensity score-matched patients with and without early steroid pulse therapy in our study population, including all clinical subtypes of IAE. In our study population including all clinical subtypes of IAE, after adjusting for the factors in Table 1 , we did not observe a significant difference in the proportions of unfavorable outcomes or in-hospital mortality between the patients with and without early steroid pulse therapy within 2 days. cache = ./cache/cord-030502-mvlib8ol.txt txt = ./txt/cord-030502-mvlib8ol.txt === reduce.pl bib === id = cord-031129-wqkdug42 author = Carr, Zyad J. title = An Update on Systemic Sclerosis and its Perioperative Management date = 2020-08-29 pages = extension = .txt mime = text/plain words = 4637 sentences = 232 flesch = 27 summary = RECENT FINDINGS: Evidence shows that patients with SSc demonstrate an increased risk for perioperative myocardial infarction, high rates of interstitial lung disease, pulmonary arterial hypertension, neurological disease, gastric dysmotility disorders, and challenging airway management, all findings that may result in suboptimal perioperative outcomes. Optimal perioperative management and risk stratification should expand beyond the well-described airway challenges and consider numerous systemic manifestations of systemic sclerosis such as pulmonary arterial hypertension, interstitial lung disease, and cardiac sequelae. Separately, pulmonary hypertension related to ILD or SScrelated cardiac involvement may increase both morbidity and mortality in the perioperative period and may be present in 8-12% of SSC patients [23, 25•] . Microstomia is likely a prominent physical feature of challenging airway management in the patient with SSc supported by a meta-analysis of 15 studies that examined risk factors for intensive care unit-related mortality in a mixed ILD population and found a strong correlation between mortality and the application of invasive mechanical ventilation [69] . cache = ./cache/cord-031129-wqkdug42.txt txt = ./txt/cord-031129-wqkdug42.txt === reduce.pl bib === id = cord-030149-hkpjnqm9 author = Fioratti, Iuri title = Strategies for a safe and assertive telerehabilitation practice date = 2020-08-07 pages = extension = .txt mime = text/plain words = 1804 sentences = 125 flesch = 35 summary = Therefore, we have developed a series of practical recommendations that may guide physical therapists throughout the use of technology for the treatment of their patients (Table 1 ). 5, 6 Best practice for chronic musculoskeletal pain includes provision of education/information about the patients' condition and management strategies and encouragement to pursue physical activity or exercises. 7, 19 Previous studies showed barriers to development of therapeutic alliance related to lack of visual cues and misunderstanding, therefore requiring advanced communication skills from clinicians to ensure best telerehabilitation practice. 17 The evidence on acceptability of remote delivery of interventions for a diverse range of medical conditions (eg, pain management, post-surgery, cardiac and pulmonary conditions) 12,29---31 indicate mostly positive findings, including a feeling of closeness despite the distance, 11 ongoing support from health professionals, 32 and continuous motivation for learning. Presenting clear and practical recommendations for telerehabilitation may empower clinicians to better use technology as an alternative mode of delivering physical therapy. cache = ./cache/cord-030149-hkpjnqm9.txt txt = ./txt/cord-030149-hkpjnqm9.txt === reduce.pl bib === id = cord-005460-ezrn8cva author = nan title = Physicians – Poster Session date = 2017-07-28 pages = extension = .txt mime = text/plain words = 287105 sentences = 15681 flesch = 56 summary = Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . cache = ./cache/cord-005460-ezrn8cva.txt txt = ./txt/cord-005460-ezrn8cva.txt === reduce.pl bib === id = cord-023354-f2ciho6o author = nan title = TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date = 2005-06-08 pages = extension = .txt mime = text/plain words = 130046 sentences = 7333 flesch = 54 summary = • enhancement of automation/computerisation; • process control to provide an 'error-free pathway'; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody 'combi' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas' disease infection (for retrieval of otherwise wasted blood); • European Union's in vitro diagnostics directive: this has caused some problems and reduced flexibility. cache = ./cache/cord-023354-f2ciho6o.txt txt = ./txt/cord-023354-f2ciho6o.txt === reduce.pl bib === id = cord-023346-8sqbqjm1 author = nan title = MONDAY: POSTERS date = 2005-06-08 pages = extension = .txt mime = text/plain words = 130043 sentences = 7330 flesch = 54 summary = • enhancement of automation/computerisation; • process control to provide an 'error-free pathway'; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody 'combi' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas' disease infection (for retrieval of otherwise wasted blood); • European Union's in vitro diagnostics directive: this has caused some problems and reduced flexibility. cache = ./cache/cord-023346-8sqbqjm1.txt txt = ./txt/cord-023346-8sqbqjm1.txt === reduce.pl bib === id = cord-030369-4dn02a35 author = Peng, Liang title = Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure) date = 2019-05-21 pages = extension = .txt mime = text/plain words = 35858 sentences = 1603 flesch = 38 summary = Once pulmonary infection is present, the disease condition will likely deteriorate, directly causing death; (3) a majority of infections are nosocomial infection, and pathogens are usually resistant to common antibiotics, making therapy challenging; (4) the pathogens causing infection are diverse but mainly Gram-negative bacteria, although the incidence of Gram-positive and fungal infections is increasing; (5) infection is closely related to the prognosis for liver failure patients. Although their clinical manifestation differ significantly, the "coexistence of acute and chronic failures" is shared by failures of all those organs; (2) CLF classification has been generally recognized at home and abroad, and the necessity of classification are further proved by the difference between CLF and the other three types; (3) CLF cases are relatively large in proportion (nearly 30%), which is still increasing (since the proportion of ALF/SALF are lowering); (4) Complications of CLF are common and are found in various forms, with bad prognosis; (5) In CLF patients with correlation to HBV, virus replication are commonly found, which is closely related to decompensation. cache = ./cache/cord-030369-4dn02a35.txt txt = ./txt/cord-030369-4dn02a35.txt === reduce.pl bib === id = cord-030897-c88tjrai author = Aljohani, Amal H. title = Clinical and Immunological Characterization of Combined Immunodeficiency Due to TFRC Mutation in Eight Patients date = 2020-08-27 pages = extension = .txt mime = text/plain words = 3484 sentences = 216 flesch = 52 summary = PURPOSE: Combined immunodeficiency (CID), due to mutations in TFRC gene that encodes the transferrin receptors (TfR1), is a rare monogenic disorder. Nevertheless, the high rate of consanguineous marriages in the Saudi population [7] and the availability of advanced molecular genetic testing provided us with the opportunity to identify and review a relatively large number of patients with combined immunodeficiency due to mutated TFRC in great detail. The observed neurological involvement in some of the patients in the form of developmental delay, milestone regression, and optic atrophy could be related to recurrent infections and prolonged hospitalization, or it could be part of the disease itself, as mitochondrial iron supply may be affected by this mutation [11] [12] [13] [14] [15] [16] . Patients with WAS and TFRC gene mutations tend to have recurrent infections and thrombocytopenia. The lymphocyte requirement of transferrin and impaired TfR signaling role impaired lymphocyte proliferation to PHA in patients with TFRC gene mutations [4, 17] . cache = ./cache/cord-030897-c88tjrai.txt txt = ./txt/cord-030897-c88tjrai.txt === reduce.pl bib === id = cord-032588-8bfl2qy1 author = nan title = 51. Jahrestagung der Österreichischen Gesellschaft für Innere Medizin date = 2020-09-18 pages = extension = .txt mime = text/plain words = 7862 sentences = 837 flesch = 54 summary = Conclusion: In hospitalized patients CoV is associated with a longer LOS, higher number of complications and much higher in-hospital mortality rates compared to influenza virus infections even in a population with less comorbidities. Women with acute heart failure or >75 years have an increased risk of influenza associated in-hospital mortality, while ICU admission and any malignancy are predictors for male patients. Die Eingriffssicherheit wurde anhand der dokumentierten peri-und postinterventionellen Komplikationen bewertet.Ergebnisse: Von April 2019 bis Februar 2020 wurden 14 Patienten mit NYHA II (33 %) oder III (67 %) aufgrund einer TI Grad III-V mittels Implantation eines oder mehrerer MC an der Trikuspidalklappe behandelt. Pro Patient wurden zwischen 1 und 4 Clips an der Trikuspidalklappe implantiert ( Grundlagen: Roxadustat ist ein oraler "Hypoxia-induceable factor"-Prolyhydroxylase-Inhibitor zur Behandlung von Patienten mit Anämie bei chronischer Niereninsuffizienz (CNI). Der vorliegende Abstract zeigt die Resultate einer Interimsanalyse.Methodik: Die Studie schließt Patienten mit NDP-CNI im Stadium 3 bis 5 mit begleitender Anämie ein und hat sie zu Roxadustat-oder DA-Therapie randomisiert. cache = ./cache/cord-032588-8bfl2qy1.txt txt = ./txt/cord-032588-8bfl2qy1.txt === reduce.pl bib === id = cord-024651-578c9ut5 author = nan title = 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2020-05-11 pages = extension = .txt mime = text/plain words = 84560 sentences = 5089 flesch = 47 summary = Abstract/Case Report Text Introduction: Mutations in the gene encoding signal transducer and activator of transcription 3 (STAT3) cause autosomal dominant hyperimmunoglobulin E syndrome (AD-HIES) characterized by recurrent skin and sinopulmonary infections, atopic dermatitis, and elevated serum immunoglobulin E (IgE) levels. Objective: The purpose of this study is to increase awareness and improve diagnosis of primary immune deficiency (PID) in the heterogenous group of patients with autoimmune cytopenia (AIC) by identifying clinical characteristics and laboratory biomarkers that distinguish those with underlying PID, disease activity and guide mechanism-based targeted therapy. 7 Chief, Laboratory of Clinical Immunology and Microbiology/National Institute of Allergy and Infectious Diseases, NIAID/National Institutes of Health, NIH Abstract/Case Report Text We have previously used the artificial thymic organoid (ATO) system, based on the 3D aggregation and culture of a delta-like canonical Notch ligand 4-expressing stromal cell line (MS5-Dll4) with CD34+ cells, to study T cell differentiation from CD34+ cells obtained from patients carrying defects that are intrinsic to hematopoietic cells (RAG1-2, AK2, IL2RG) or that affect thymus development (DiGeorge syndrome). cache = ./cache/cord-024651-578c9ut5.txt txt = ./txt/cord-024651-578c9ut5.txt === reduce.pl bib === id = cord-032335-6c9gt7t9 author = Segrelles-Calvo, Gonzalo title = Therapeutic limitation in elderly patients: Reflections regarding COVID19() date = 2020-09-19 pages = extension = .txt mime = text/plain words = 1309 sentences = 65 flesch = 52 summary = In a recent editorial, published in The New England Journal of Medicine, the authors address the problem of having to choose between 2 or more patients for the assignment of resources, such as ICU admission. This real situation that arose during the Covid-19 pandemic underlines the need to develop fair resource allocation procedures that include all the stakeholders involved in patient care, and the patient and family themselves, in order to develop prioritization criteria for decisionmaking in times of adversity, without transferring this burden to a single healthcare professional in a specific situation. Among the many changes that will emerge after the Covid-19 pandemic, we believe that one of the most relevant will surely be the expansion of RICUs and the leadership of respiratory medicine in decision-making on borderline patients, such as the elderly, unifying selection criteria, clarifying the concept of frailty, and integrating its use into our clinical practice. cache = ./cache/cord-032335-6c9gt7t9.txt txt = ./txt/cord-032335-6c9gt7t9.txt === reduce.pl bib === id = cord-023049-fio7cjj5 author = nan title = 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date = 2017-06-22 pages = extension = .txt mime = text/plain words = 145485 sentences = 7436 flesch = 48 summary = Clinical efficacy (Medical Research Council sum score, 10-m walk, modified Inflammatory Neuropathy Cause and Treatment score, Overall Neuropathy Limitations Scale, Romberg test) and patient-reported outcomes (36-item Short Form Health Survey , Life Quality Index [LQI] ) were assessed at baseline and at regular intervals until the final visit (10-14 months after switching). To explore the issue of early biomarkers in FAP, we performed skin biopsy and compared IENF density with parameters of nerve conduction studies (NCS) and quantitative sensory testing (QST) on 36 subjects (23 men, aged 55.1 ± 11.1 years) with genetic confirmation of TTR-A97S: 17 patients and 19 carriers. Results: The Gly112Ser mutation causing CMT1C is a mild form of CMT, as patients walked on time, had less weakness than those with Charcot-Marie-Tooth Disease type 1A (CMT1A), had a Charcot Marie Tooth neuropathy score (CMTNS) indicative of mild disease, and had faster ulnar and median motor nerve conduction velocities compared to those with CMT1A. cache = ./cache/cord-023049-fio7cjj5.txt txt = ./txt/cord-023049-fio7cjj5.txt === reduce.pl bib === id = cord-033279-bcf9568a author = Vujaklija Brajković, Ana title = Utility of procalcitonin in a medical intensive care unit in Croatia date = 2020-10-06 pages = extension = .txt mime = text/plain words = 4013 sentences = 200 flesch = 38 summary = Levels of PCT and CRP were significantly increased in patients with positive blood cultures, the infection caused by Gram-negative microorganism regardless of disease severity and pneumonia with complications. In the critical care setting, published studies differ greatly considering patient case mix [3] [4] [5] [6] [7] , the source of infection [3, 4, [6] [7] [8] [9] [10] [11] [12] [13] , the severity of the disease [4, 5, [10] [11] [12] 14] , exclusion criteria as well as cut-offs and laboratory methods for PCT measurements [3, 11, [13] [14] [15] . The PCT and CRP levels were significantly increased in patients with positive blood cultures, the infection caused by Gram-negative microorganism regardless of disease severity (no difference in SOFA and APACHE II scores), and pneumonia with complications (Table 3) . cache = ./cache/cord-033279-bcf9568a.txt txt = ./txt/cord-033279-bcf9568a.txt === reduce.pl bib === id = cord-031710-1xl2isee author = Andrei, Stefan title = Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia – case report date = 2020-09-10 pages = extension = .txt mime = text/plain words = 2582 sentences = 137 flesch = 40 summary = title: Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia – case report CASE PRESENTATION: We present the rare case of successful outcome in a 61-year-old female who developed alveolar haemorrhage and acute respiratory distress syndrome 8 days after a chemotherapy session for her acute lymphoblastic leukaemia, in the context of secondary bone marrow aplasia. We report the case of successfully treated severe Stenotrophomonas maltophilia respiratory infection complicated with pulmonary haemorrhage in a chemotherapyinduced pancytopenia patient diagnosed with acute lymphoblastic leukaemia. To our knowledge, this is the first reported case of pulmonary haemorrhage and ARDS caused by a fulminant Stenotrophomonas maltophilia respiratory infection in Eastern Europe, and it seems to be a rare case of positive outcome in a patient with haematological malignancy. cache = ./cache/cord-031710-1xl2isee.txt txt = ./txt/cord-031710-1xl2isee.txt === reduce.pl bib === id = cord-030216-l38i06v2 author = Liao, Kuang-Ming title = Hospital costs and prognosis in end-stage renal disease patients receiving coronary artery bypass grafting date = 2020-08-08 pages = extension = .txt mime = text/plain words = 3702 sentences = 198 flesch = 44 summary = METHODS: This study analyzed data from the National Health Insurance Research Database in Taiwan for patients who were diagnosed with ESRD and received CABG (ICD-9-CM codes 585 or 586) between January 1, 2004, and December 31, 2009. There have been limited studies investigating the prognosis, risk factors and hospital costs of CABG between ESRD and non-ESRD patients. Thus, the aim of our study was to assess whether ESRD patients on hemodialysis who received CABG experienced higher hospital costs and perioperative and postoperative mortality than CABG patients without ESRD and to evaluate the factors related to outcomes between the two groups. Second, the risk factors for mortality after CABG were hypertension, diabetes, myocardial infarction history, stroke and COPD in ESRD patients compared with non-ESRD patients. ESRD patients with regular hemodialysis, old age, diabetes, and hypertension are at increased risk of stroke [23] [24] [25] , but our study found that these factors were not significantly associated with mortality among ESRD patients after CABG. cache = ./cache/cord-030216-l38i06v2.txt txt = ./txt/cord-030216-l38i06v2.txt === reduce.pl bib === id = cord-030380-okue1kso author = McWilliams, J. Michael title = Professionalism Revealed: Rethinking Quality Improvement in the Wake of a Pandemic date = 2020-07-22 pages = extension = .txt mime = text/plain words = 5912 sentences = 290 flesch = 43 summary = Conceptually, with informed and motivated professionals as their agents, patients effectively become discerning consumers capable of driving healthy competition in health care markets where extrinsic pressure may be needed to encourage highquality care (e.g., primary care physicians [PCPs] directing patients to the safest hospitals or surgeons selecting the best devices). (This article focuses largely on physician agency as an instructive case, but other health care professionals act as agents, too, presenting analogous issues that are no less important.) Potential refinements notwithstanding, the dissatisfying pace of quality improvement over the last 2 decades should tell us that measure-reliant approaches are unlikely to deliver on their promise." As the concept of quality is reduced to that which is measured, improvement redefined as higher scores, extrinsic judgments elevated above unseen efforts, and time for patients and colleagues hijacked by box-checking, demoralization sets in.17 , 18 Purpose is undermined as demands on physicians diverge from their values, professional identity is lost, and intrinsic motivation gives way to a self-fulfilling prophecy that physicians care only about financial incentives. cache = ./cache/cord-030380-okue1kso.txt txt = ./txt/cord-030380-okue1kso.txt === reduce.pl bib === === reduce.pl bib === id = cord-031256-4mxt501d author = Van Der Poorten, Marie-Line M. title = Non-irritating skin test concentrations for ceftazidime and aztreonam in patients with a documented beta-lactam allergy. date = 2020-09-01 pages = extension = .txt mime = text/plain words = 1724 sentences = 121 flesch = 60 summary = Our study shows that the maximal non-irritant concentration (NIC) for ceftazidime and for aztreonam 32 is as high as 20 mg/mL for immediate readings of intradermal skin tests (IDT). (1) 42 This study aims at assessing the NIC for ceftazidime, a third generation cephalosporin, and 43 aztreonam, a synthetic monobactam, both potential safe alternative β-LABs in patients with a 44 documented hypersensitivity reaction to penicillin G, amoxicillin (+/-clavulanic acid) or cefazolin. Diagnosis of their Penicillin G, amoxicillin (+/-clavulanic acid) or cefazolin 52 hypersensitivity was based upon a history complemented by positive STs (immediate and delayed 53 readings), drug-reactive sIgE antibodies, a sIgE-to-tIgE ratio ≥ 0.002, or a graded drug challenge (DC). Our results show that the NICs for ceftazidime and aztreonam, as recommended in the ENDA/EAACI 102 Drug Allergy Interest Group position paper (3) and its update by Romano et al (8) , can further benefit 103 from an assessment in patients who experienced an IDHR or NIDHR to penicillin G, amoxicillin (+/-104 clavulanic acid) or an IDHR to cefazolin. cache = ./cache/cord-031256-4mxt501d.txt txt = ./txt/cord-031256-4mxt501d.txt === reduce.pl bib === id = cord-030962-2xem8inu author = Isea de la Viña, Jesus title = Lung cancer patients on the waiting list in the midst of the COVID-19 crisis: what do we do now?() date = 2020-08-28 pages = extension = .txt mime = text/plain words = 911 sentences = 54 flesch = 55 summary = Reference centers, which have a greater number of cases, have had to vacate wards and intensive care units to make room for patients infected with the coronavirus, so the impossibility of transferring surgical patients from regional to tertiary hospitals to receive specialized care and the waiting list delays caused by the suspension of scheduled operations will soon have an impact on patients with lung cancer (LC) not infected by this virus. The American College of Surgeons (ACS), 1 in their recently published guidelines on the management of patients scheduled for thoracic surgery, categorize the general status of hospitals into 3 phases according to the number of COVID-19 patients admitted: phase 1 -preparation; phase 2 -urgent setting; and phase 3 -ଝ Please cite this article as: Isea de la Viña J, Mayol J, Ortega AL, Alcázar Navarrete AN. cache = ./cache/cord-030962-2xem8inu.txt txt = ./txt/cord-030962-2xem8inu.txt === reduce.pl bib === id = cord-023364-ut56gczm author = nan title = EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date = 2005-06-08 pages = extension = .txt mime = text/plain words = 130049 sentences = 7334 flesch = 54 summary = • enhancement of automation/computerisation; • process control to provide an 'error-free pathway'; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody 'combi' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas' disease infection (for retrieval of otherwise wasted blood); • European Union's in vitro diagnostics directive: this has caused some problems and reduced flexibility. cache = ./cache/cord-023364-ut56gczm.txt txt = ./txt/cord-023364-ut56gczm.txt === reduce.pl bib === === reduce.pl bib === id = cord-030361-0tepkjdl author = Mohammed Abdul, Mubeen Khan title = Hepatitis C Virus in the Elderly in the Direct-Acting Antiviral Era: from Diagnosis to Cure date = 2020-08-11 pages = extension = .txt mime = text/plain words = 4991 sentences = 233 flesch = 42 summary = In a study conducted by Foster and colleagues, data was combined from nine phase 2 and phase 3 clinical trials to evaluate efficacy and safety outcomes in HCV patients ≥ 65 years old treated with the pan-genotypic regimen, glecaprevir/pibrentasvir, for 8, 12, or 16 weeks [28] . Shiffman and colleagues reported outcomes of 123 patients aged 65 years or older enrolled in three phase 3 studies who received sofosbuvir/velpatasvir, a pan-genotypic DAA, for 12 weeks for the treatment of chronic HCV [29] . Safety and efficacy of sofosbuvir/ velpatasvir for the treatment of chronic hepatitis C in patients aged 65 years or older: a retrospective analysis of phase 3 studies The efficacy and safety of direct acting antiviral treatment and clinical significance of drug-drug interactions in elderly patients with chronic hepatitis C virus infection cache = ./cache/cord-030361-0tepkjdl.txt txt = ./txt/cord-030361-0tepkjdl.txt === reduce.pl bib === id = cord-023157-0lqlx2rv author = nan title = Poster Sessions date = 2013-04-18 pages = extension = .txt mime = text/plain words = 128430 sentences = 7726 flesch = 55 summary = The patients revealed the increase of free fatty acids level (2.19 AE 0.10) mmol/l/ml, that meaningfully differed from such indexes in the control group (P < 0.001) and low level of adiponektin (3.70 AE 0.70) mg/ml that confirms their role in development of NAFLD even for persons with normal body weight after the presence of abdominal type of adipose tissue distribution. Results: This study has shown effectiveness in reduction in fasting blood glucose (P < 0.01), systolic blood pressure (P = 0.03), diastolic blood pressure (P = 0.01), weight (P = 0.03), added sugar (P = 0.03) and fat consumption (P < 0.01) while improving physical activity (P < 0.01) and insulin sensitivity (P < 0.01) in the intervention group when compared with the control group at follow up assessment. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. cache = ./cache/cord-023157-0lqlx2rv.txt txt = ./txt/cord-023157-0lqlx2rv.txt === reduce.pl bib === id = cord-032544-2yrqjw1o author = Haroon, Sabrina-Wong-Peixin title = Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial date = 2020-09-04 pages = extension = .txt mime = text/plain words = 5232 sentences = 276 flesch = 41 summary = title: Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial DISCUSSION: Evidence of successful regression or retardation of vascular calcification will support the conduct of larger and longer-term trials aimed at reducing cardiovascular disease mortality and major adverse cardiovascular events in this high-risk population using a safe and inexpensive strategy TRIAL REGISTRATION: ClinicalTrials.gov NCT02870829. [27] A recent randomized trial reporting 1-year outcome of vitamin K2 supplementation in hemodialysis patients found no effect on aortic calcification despite reduction in dp-ucMGP. The proposed "Treatment to Reduce Vascular Calcification in Hemodialysis Patients Using Vitamin K" (Trevasc-HDK) study is therefore timely. Our trial is important even if the study is negative as we will have more insight into the baseline level and role of vitamin Kin Asian patients as well as provide us with the magnitude and progression of calcification in our multiethnic HD population. The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial cache = ./cache/cord-032544-2yrqjw1o.txt txt = ./txt/cord-032544-2yrqjw1o.txt === reduce.pl bib === id = cord-032928-m0awip9y author = Sobh, Eman title = Novel coronavirus disease 2019 (COVID-19) non-respiratory involvement date = 2020-10-01 pages = extension = .txt mime = text/plain words = 4021 sentences = 242 flesch = 43 summary = Coronavirus disease 2019 (COVID-19) is caused by a novel single-strand ribonucleic acid (RNA) coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 primary attacks the lower respiratory system causing viral pneumonia, but it may also affect the heart, gastrointestinal system, liver, kidney, and central nervous system leading to multiple organ failure [3] . Other researchers found elevated serum troponin levels in many patients infected with COVID-19, and it was associated with more severe disease and poor prognosis [21] . The mechanism behind acute myocardial injury caused by SARS-CoV-2 infection might be related to human angiotensin-converting enzyme 2 receptor (ACE2) [20] which are highly expressed in the heart [11] . The results of previous reports indicate that cardiac injury, arrhythmia, and venous thromboembolism should be considered in any suspected or confirmed COVID-19 case and the patient should undergo a prompt clinical evaluation. cache = ./cache/cord-032928-m0awip9y.txt txt = ./txt/cord-032928-m0awip9y.txt === reduce.pl bib === === reduce.pl bib === id = cord-032392-ex3s8evv author = Matthews, Tamyra title = Single cases from multiple perspectives: a qualitative study comparing the experiences of patients, patients’ caregivers, surgeons, and nurses when bad news is delivered about cancer date = 2020-09-18 pages = extension = .txt mime = text/plain words = 6761 sentences = 345 flesch = 58 summary = Interpretative phenomenological analysis (IPA) provided the theoretical framework to examine semistructured interviews exploring participants' lived experiences of the breaking bad news process, and then to directly compare patients', caregivers', and HCPs' accounts that were linked to the same patient's case. The current study sample was determined by the number of linked cases that were able to be formed from the data collected for a larger doctoral study exploring the perspectives of 4 different groups involved in the bad news process: patients, caregivers, surgeons, and nurses. In linked cases that included the bad news deliverer and receiver perspective, the direct comparison highlighted the importance of HCPs recognizing and attending to patients' and caregivers' specific emotional needs ("noticing and meeting emotional needs") and delivering information in the way that suited each patient ("reading different informational needs"). cache = ./cache/cord-032392-ex3s8evv.txt txt = ./txt/cord-032392-ex3s8evv.txt === reduce.pl bib === === reduce.pl bib === id = cord-033135-cxsmxk3b author = Palomo Cobos, Luis title = Chronicity and primary care in times of pandemic() date = 2020-10-03 pages = extension = .txt mime = text/plain words = 1796 sentences = 72 flesch = 46 summary = 1 During the lockdown, primary care professionals reorganized to attend to mild cases at home and actively follow up people with greater vulnerability by phone, caring for their health and avoiding the complications that would require hospital admission. The current situation of the health crisis provoked by COVID-19 and the isolation measures imposed by the state of alarm decreed on 14th March led to the break-down of a series of routines and actions upon which the care of these patients was based, with their continued application being lost. An evaluation (Table 1 ) aimed at determining the functional, mental and social health situation of patients is therefore a way to detect possible changes or delays which occurred throughout lockdown and it is the necessary step before establishing new healthcare interventions, or the assignment of new resources and social-health resources and re-assessment. cache = ./cache/cord-033135-cxsmxk3b.txt txt = ./txt/cord-033135-cxsmxk3b.txt === reduce.pl bib === id = cord-031821-rywdkqcd author = Borregón Rivilla, Miguel title = Coronavirus infection in cancer patients, last update() date = 2020-09-12 pages = extension = .txt mime = text/plain words = 2134 sentences = 115 flesch = 50 summary = In relation to the data we have on the behaviour of the coronavirus pandemic in cancer patients, there are many studies that are being carried out and few already published. The symptomatology has been the usual one observed in the general population with coronavirus infection, highlighting dyspnoea as the main symptom that defines seriously ill patients. The low percentage of the population of cancer patients must be taken into account in most studies, limiting the interpretation that can be made of these data. We hope that clinical and therapeutic studies of coronavirus infection will soon emerge, to shed light on the health crisis we are experiencing. Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan Clinical characteristics and prognosis in cancer patients with COVID-19: A single center's retrospective study A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group cache = ./cache/cord-031821-rywdkqcd.txt txt = ./txt/cord-031821-rywdkqcd.txt === reduce.pl bib === id = cord-031191-63xtga7h author = Barrios Espinosa, Cristian title = Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication date = 2020-08-06 pages = extension = .txt mime = text/plain words = 1819 sentences = 100 flesch = 41 summary = title: Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication These devel-opments create opportunities for early detection of recurrent AF in patients with transitory AF events during acute illness or following non-cardiac surgery, enabling subsequent initiation of anticoagulation and other therapies. Patients without a history of AF and who reverted to sinus rhythm before discharge were included in the study and used a handheld single-lead ECG device for self-monitoring of AF recurrence 3 times per day for 4 weeks. [17] supports the notion that AF recurrence in patients with secondary AF in the setting of non-cardiac surgery or acute illness is common and has potentially important clinical consequences. Self-monitoring for atrial fibrillation recurrence in the discharge period post-cardiac surgery using an iPhone electrocardiogram Selfmonitoring for recurrence of secondary atrial fibrillation following noncardiac surgery or acute illness: a pilot study cache = ./cache/cord-031191-63xtga7h.txt txt = ./txt/cord-031191-63xtga7h.txt === reduce.pl bib === id = cord-033778-u2r0neyc author = Taban, EM title = Observational study of therapeutic bronchoscopy in critical hypoxaemic ventilated patients with COVID-19 at Mediclinic Midstream Private Hospital in Pretoria, South Africa date = 2020-10-13 pages = extension = .txt mime = text/plain words = 2577 sentences = 146 flesch = 48 summary = Flexible fibreoptic bronchoscopy (FFB) has been used for years as a diagnostic and therapeutic adjunct for the diagnosis of potential airway obstruction as a cause of acute respiratory failure or in the management of hypoxaemia ventilated patients. To evaluate the use of FFB as a rescue therapy in mechanically ventilated patients with severe hypoxaemic respiratory failure caused by COVID-19. Patients with severe COVID-19 pneumonia who have persistent hypoxaemia despite the resolution of inflammatory parameters may respond to FFB with removal of mucus plugs. These patients had severe COVID-19 pneumonia with the following characteristics: severe refractory hypoxaemia despite maximal mechanical ventilatory support, including proning and significant deterioration from previous minimal ventilator settings. We have demonstrated that some patients with severe COVID-19 pneumonia and persistent hypoxaemia despite resolution of inflammatory parameters may respond to FFB following removal of mucus plugs. cache = ./cache/cord-033778-u2r0neyc.txt txt = ./txt/cord-033778-u2r0neyc.txt === reduce.pl bib === id = cord-031734-5wnvuk2n author = Wichlas, F. title = War surgery in Afghanistan: a model for mass causalities in terror attacks? date = 2020-09-11 pages = extension = .txt mime = text/plain words = 3120 sentences = 196 flesch = 57 summary = PURPOSE: The aim of the study was to identify solution strategies from a non-governmental (NGO) hospital in a war region for violence-related injuries and to show how high-income countries (HIC) might benefit from this expertise. Apart from surgical wound care and debridements, which were performed on every wound in the operation theatre, laparotomy was the most common surgical procedure, followed by installation of a chest drainage and amputation. The lack of surgical experience might not be relevant as long as a hospital provides a specialist for every probable pathology, but in cases of a sudden high volume of causalities like in a terror attack or train accident, adequate treatment of the injured could get difficult [7, 8] . As much as medical standards in LIC and war zones lag behind, there might be a potential knowledge of primary injury treatment and basic surgical techniques, expectable injury patterns, and experience in dealing with mass causalities by fast decision-making. cache = ./cache/cord-031734-5wnvuk2n.txt txt = ./txt/cord-031734-5wnvuk2n.txt === reduce.pl bib === id = cord-034257-kl2ccmz5 author = de Jonge, Jeroen C. title = PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date = 2020-10-26 pages = extension = .txt mime = text/plain words = 3731 sentences = 209 flesch = 51 summary = title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment AIMS AND DESIGN: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS) is an international, multi-centre, 3 × 2 factorial, randomised, controlled, open-label clinical trial with blinded outcome assessment, which will assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, respectively, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in elderly patients with acute stroke. The primary objective is to assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in older patients with acute stroke. cache = ./cache/cord-034257-kl2ccmz5.txt txt = ./txt/cord-034257-kl2ccmz5.txt === reduce.pl bib === id = cord-022888-dnsdg04n author = nan title = Poster Sessions date = 2009-08-19 pages = extension = .txt mime = text/plain words = 188640 sentences = 9313 flesch = 45 summary = Methods: Phospho-specific Western blot analyses were performed to verify the functionality of the different IFN-g pathway components, intra-and extracellular flow cytometry experiments were employed to determine the expression of antigen processing components and HLA class I cell surface antigens, quantitative real time-PCR experiments to confirm the absence of JAK2 and presence of pathway relevant molecules as well as, genomic PCR and chromosome typing technique to prove the deletion of JAK2. In order to accomplish these objectives we induced priming or tolerance of ovalbumin (OVA 323-339 peptide)-specific T cells from DO11.10 TCR transgenic mice in vitro or, following adoptive transfer of near physiologically relevant numbers of such cells into recipients, in vivo and correlated functional outcome (via proliferation and cytokine readout assays or antibody production) with E3 ubiquitin-protein ligases expression and the ubiquitination status of the TCR signalling machinery. cache = ./cache/cord-022888-dnsdg04n.txt txt = ./txt/cord-022888-dnsdg04n.txt === reduce.pl bib === id = cord-033574-4y53ryoa author = Tashiro, Hiroki title = Biomarkers for Overweight in Adult-Onset Asthma date = 2020-10-02 pages = extension = .txt mime = text/plain words = 2693 sentences = 140 flesch = 53 summary = On serum cytokine and chemokine analyses, the overweight asthma group included significantly more patients with a lower level of tissue growth factor α (TGF-α) (1.1 pg/mL) and higher levels of hsIL-6 (2.5 pg/mL), RANTES/CCL5 (298.5 pg/mL), and vascular endothelial growth factor A (VEGF-A) (63.7 pg/mL), than the non-overweight asthma group (p=0.02, p<0.01, p=0.02, p=0.01, respectively). CONCLUSION: The present study showed that overweight patients with adult-onset asthma were characterized by a higher rate of annual exacerbations and worse lung function despite treatment with high-dose inhaled corticosteroids and lower blood eosinophil counts than non-overweight patients with asthma. 7 Thus, the present study focused only on adult-onset asthma and showed that blood eosinophil counts were significantly lower in overweight patients with asthma than in non-overweight patients with asthma (Table 1) , and they were negatively correlated with BMI (Figure 1 ), consistent with low type 2 inflammation, as described in previous reports. cache = ./cache/cord-033574-4y53ryoa.txt txt = ./txt/cord-033574-4y53ryoa.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-031497-pp0p3en6 author = Rodríguez-Fuster, Alberto title = Tracheal trauma in the context of the current infection by COVID-19. About 2 cases() date = 2020-09-06 pages = extension = .txt mime = text/plain words = 1153 sentences = 79 flesch = 53 summary = Various authors and scientific societies have recommended limiting the number of airway procedures and manipulations and introducing stringent protection measures for health personnel in order to minimize the risk of infection. [2] [3] [4] We report 2 cases of patients diagnosed with SARS-CoV-2 infection and tracheal iatrogenic rupture following airway manipulation. She required OTI + MV for respiratory failure, and during the procedure she incurred a tracheal lesion confirmed by computed tomography and fiberoptic bronchoscopy to be a rupture of the pars membranacea measuring approximately 2 cm. To minimize the risk of aerosols, the patient was maintained in complete muscle relaxation throughout the procedure; preoxygenation and ventilatory pauses-apneas-were performed (as far as possible) in accordance with the recommendations described for tracheotomy. Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations Tracheal trauma after difficult airway management in morbidly obese patients with COVID-19 cache = ./cache/cord-031497-pp0p3en6.txt txt = ./txt/cord-031497-pp0p3en6.txt === reduce.pl bib === id = cord-015324-y44sfr0c author = nan title = Scientific Programme date = 2007-09-01 pages = extension = .txt mime = text/plain words = 197618 sentences = 12774 flesch = 53 summary = In order to further validate this approach, we performed a prospective randomized open-label multicenter trial in 41 low-risk pediatric renal transplant recipients (12 f, 29 m; mean age 10.1 yrs; range, 3.4 to 17.8) on CsA (target trough level 100-200 ng/ml), MMF (1200 mg/m 2 per day) and methylprednisolone (3) (4) mg/m 2 per day), who were randomly assigned >1 year posttransplant to continue steroids or to withdraw over a period of 3 months. We evaluated MMF in 15 children with LN, 11 F/4 M, mean age: 12.4±3.9 yrs, proteinuria >3 g/day, decreased C3 and increased anti-dsDNA serum levels, normal renal function. Patients and methods: 91 children and adolescents (60 male, 31 female, mean age at transplantation 9.7±5.2 years) with stable renal function and observation period exceeding 6 months were included. cache = ./cache/cord-015324-y44sfr0c.txt txt = ./txt/cord-015324-y44sfr0c.txt === reduce.pl bib === id = cord-032930-ohsh46l2 author = Liu, Priscila Menezes Ferri title = Hepatorenal syndrome in children: a review date = 2020-10-01 pages = extension = .txt mime = text/plain words = 7405 sentences = 417 flesch = 42 summary = Hepatorenal syndrome (HRS) occurs in patients with cirrhosis or fulminant hepatic failure and is a kind of pre-renal failure due to intense reduction of kidney perfusion induced by severe hepatic injury. Hepatorenal syndrome occurs in patients with cirrhosis or fulminant hepatic failure and is a kind of pre-renal failure due to intense reduction of kidney perfusion induced by increasingly severe hepatic injury. The persistence of these conditions may cause cardiac dysfunction and decreased kidney function, Legend: SNS, sympathetic nervous system; ADH, antidiuretic hormone; NO, nitric oxide; CO, carbon monoxide; PI 2 , prostaglandin I 2 ; EET, epoxyeicosatrienoic acid; CE, endogenous cannabinoids; Ang I, angiotensin I; Ang II, angiotensin II; Ang-(1-7), angiotensin (1) (2) (3) (4) (5) (6) (7) subunit) in cirrhotic rats as a response to CO stimulation was also reported [16] . cache = ./cache/cord-032930-ohsh46l2.txt txt = ./txt/cord-032930-ohsh46l2.txt === reduce.pl bib === id = cord-034286-m1c98nv7 author = Wijdicks, Eelco F. M. title = Communicating Neurocritical Illness: The Anatomy of Misunderstanding date = 2020-10-27 pages = extension = .txt mime = text/plain words = 3537 sentences = 244 flesch = 54 summary = One starting point for those practicing acute neurology and neurocritical care is a new mnemonic TELL ME (Time course, Essence, Laboratory, Life-sustaining interventions, Management, Expectation), which will assist physicians in standardizing their communication skills before they start a conversation or pick up a phone. These include knowing the time course (new and "out of the blue" or ongoing for some time); extracting the essentials (eliminating all irrelevancies); communicating what tests are known and pending (computerized tomography and laboratory); relaying how much critical support will be needed (secretion burden, intubation, vasopressors); knowing fully which emergency drugs have been administered (e.g., mannitol, antiepileptics, tranexamic acid), when transport is anticipated, and what can be expected in the following hours. In any case, improved provider perceptions of transfer workflow efficiency and patient safety may not be enough; communication must also include solutions for active medical problems and an outline of anticipatory guidance ("what if-what then" scenarios) in the event an acute change in clinical condition occurs. cache = ./cache/cord-034286-m1c98nv7.txt txt = ./txt/cord-034286-m1c98nv7.txt === reduce.pl bib === id = cord-034185-e0am7pa6 author = Piccioni, Federico title = Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date = 2020-10-23 pages = extension = .txt mime = text/plain words = 18220 sentences = 941 flesch = 37 summary = We do not recommend the routine use of either continuous positive airway pressure (CPAP) or non invasive ventilation (NIV) to prevent postoperative pulmonary complications, prolonged length of stay, and mortality (both in ICU and in hospital) in patients undergoing major thoracic surgery. Level of evidence: Fair Strength of recommendation: C A meta-analysis of 45 studies including almost 5800 patients showed that a single perioperative dose of intravenous dexamethasone resulted in significant reductions in pain scores and opioid use, and was associated with shorter stays in the post-anesthesia recovery room, compared with placebo or antiemetic treatment (Waldron et al. Level of evidence: Fair Strength of recommendation: A Multiple clinical trials have shown that, in patients undergoing open thoracotomy or other major surgical procedures, thoracic epidural analgesia (TEA) is superior to intravenous opioid administration in terms of postoperative pain relief, length of hospital stay, and incidence of postoperative complications (Hazelrigg et al. cache = ./cache/cord-034185-e0am7pa6.txt txt = ./txt/cord-034185-e0am7pa6.txt === reduce.pl bib === id = cord-032183-yqqqe325 author = Ning, Qin title = Antiviral Therapy for AECHB and Severe Hepatitis B (Liver Failure) date = 2019-05-21 pages = extension = .txt mime = text/plain words = 32675 sentences = 1658 flesch = 43 summary = Patients awaiting liver transplantation because of HBV-related end-stage liver disease or liver cancer should be given nucleoside analogues with strong HBV inhibition and low drug-resistance, or nucleotides analogues combination treatment, in order to reduce viral load and prevent graft re-infection. The objective of antiviral treatment for HBV-ACLF is to reduce viral load at an appreciably high rate, thereby promoting reduction in hepatocyte cell death and improved survival outcomes by prevention of decompensation related multiorgan complications in this group of severely ill patients. Response-Guided Therapy 4006 study [126] suggested continuous treatment with LAM (10 years) delayed clinical progression in patients with chronic hepatitis and advanced fibrosis by significantly reducing the incidence of the risk of hepatocellular carcinoma and hepatic decompensation. cache = ./cache/cord-032183-yqqqe325.txt txt = ./txt/cord-032183-yqqqe325.txt === reduce.pl bib === id = cord-033019-4eo037jp author = Garnier, Marc title = Answer to the letter by Niño et al date = 2020-10-02 pages = extension = .txt mime = text/plain words = 1095 sentences = 53 flesch = 53 summary = Indeed, the transition, even partial, from in-face to teleconsultation must be prepared and a minimum of prerequisites are necessary, such as: the availability of high-performance computer equipment; the availability of a secretariat to organise the call planning and the sending before the teleconsultation of the documents to be prepared by the patient; the use of secure applications to preserve the confidentiality of the medical data exchanged; or the training of anaesthetists in the institutional tools made available. As this PCR must be carried out as close as possible to the surgery, we agree that the result cannot be available at the time of the anaesthetic consultation. In other cases (i.e. non-aerosol-generating care and no prolonged contact within one metre), the wearing of a simple surgical mask is recommended, including for the care of a proven COVID-19 patient. cache = ./cache/cord-033019-4eo037jp.txt txt = ./txt/cord-033019-4eo037jp.txt === reduce.pl bib === === reduce.pl bib === id = cord-034303-kcu9guxa author = Laimoud, Mohamed title = The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date = 2020-10-27 pages = extension = .txt mime = text/plain words = 3194 sentences = 170 flesch = 44 summary = The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating hospital mortality and neurological outcome after VA-ECMO support for adult patients with cardiogenic shock. The non-survivors and the patients with acute cerebral strokes had significantly higher arterial lactate levels at pre-ECMO initiation, post-ECMO peak and after 24 h of ECMO support compared to the survivors and those without strokes, respectively. CONCLUSION: Progressive hyperlactatemia after VA-ECMO initiation for adult patients with cardiogenic shock is a sensitive and specific predictor of hospital mortality and acute cerebrovascular strokes. The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating in-hospital mortality and neurological outcome after VA-ECMO support for patients with cardiogenic shock. Finally, our study revealed that the hospital mortality and neurological outcome of VA-ECMO were significantly associated with the severity of pre-ECMO shock state and the appropriate recovery of organs perfusion after ECMO support as indicated with changes of blood lactate levels. cache = ./cache/cord-034303-kcu9guxa.txt txt = ./txt/cord-034303-kcu9guxa.txt === reduce.pl bib === === reduce.pl bib === id = cord-034690-x8lkngra author = Ridge, Carole A title = Dual-Energy CT Pulmonary Angiography (DECTPA) Quantifies Vasculopathy in Severe COVID-19 Pneumonia date = 2020-10-29 pages = extension = .txt mime = text/plain words = 3213 sentences = 178 flesch = 46 summary = Qualitative and quantitative analysis of perfused blood volume (PBV) maps recorded: i) perfusion defect 'pattern' (wedge-shaped, mottled or amorphous), ii) presence of PT and CT obstruction index (CTOI) and iii) PBV relative to pulmonary artery enhancement (PBV/PAenh); PBV/PAenh was also compared with seven healthy volunteers and correlated with D-Dimer and CTOI. Accordingly, in the present study we aimed to evaluate the relationships between a quantitative measure of perfusion on DECTPA (relative perfused blood volume, PBV/PAenh) (22) , and i) disease duration, ii) right ventricular dysfunction on echocardiography iii) Ddimer levels and (iv) obstruction score (23) in patients with severe COVID-19 pneumonia. This early data demonstrated perfusion defects on perfused blood volume (PBV) maps, when available, as well as the presence of vascular dilatation on conventional CT, hypercoagulability and an increased dead space in 39 patients suggesting that pulmonary angiopathy was accountable for hypoxia observed in patients requiring mechanical ventilation for severe COVID-19 pneumonia. cache = ./cache/cord-034690-x8lkngra.txt txt = ./txt/cord-034690-x8lkngra.txt === reduce.pl bib === id = cord-032244-s7t5u9lf author = Valente, Serafina title = ANMCO POSITION PAPER: Considerations on in-hospital cardiological consultations and cardiology outpatient clinics during the COVID-19 pandemic date = 2020-08-27 pages = extension = .txt mime = text/plain words = 1511 sentences = 87 flesch = 39 summary = The aim of this document is to propose algorithms for the management of cardiovascular diseases during COVID-19 emergency with the objective of providing patients with optimal care, minimizing contagion risk and appropriately managing personal protective equipment. 9, 10 The objective of this document is to propose management algorithms for cardiovascular disease during the COVID-19 emergency, in order to optimize cardiological assistance for the benefit of patients by minimizing the possibility of contagion, safeguarding healthcare personnel, and rationalizing the use of personal protective equipment (PPE). • angina pectoris • heart failure • arrhythmia In the case of a suspected COVID-19 patient, it is always necessary to try to postpone the medical exam or the appointment (if a cardiac patient cannot wait, refer them to the emergency room which has appropriate access points and safety procedures in place) or manage with the available PPE according to the risk of contagion following specific safety procedures, remembering to disinfect spaces and equipment after the exam/appointment according to local protocols. cache = ./cache/cord-032244-s7t5u9lf.txt txt = ./txt/cord-032244-s7t5u9lf.txt === reduce.pl bib === === reduce.pl bib === id = cord-034746-uxhpufnv author = Nusshag, Christian title = Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date = 2020-11-05 pages = extension = .txt mime = text/plain words = 3642 sentences = 194 flesch = 36 summary = We therefore analyzed standard markers of glomerular proteinuria (e.g. immunoglobulin G [IgG]), urinary nephrin excretion (podocyte injury) and serum levels of the soluble urokinase plasminogen activator receptor (suPAR), a proposed pathomechanically involved molecule in INS, in PUUV-infected patients. On admission, patients suffering from hantavirus infection showed significantly increased urinary nephrin, IgG, α1-MG and serum suPAR levels compared to healthy controls (Fig. 3A ). Though, urinary biomarker levels decreased in both groups over time, patients with severe PCR showed significantly higher levels of nephrin, IgG, ACR and PCR during the first 48 h after admission ( Table 2 ). Our data show a strong association between urinary nephrin levels and the extent of (non-selective) glomerular proteinuria, suggesting that hantavirus infection causes a pronounced podocyte damage and subsequent impairment of the GFB. To date, one other study showed significantly elevated blood suPAR levels and their association with hantavirus disease severity but did not include nephrinuria and the extent of proteinuria in their analysis 19 . cache = ./cache/cord-034746-uxhpufnv.txt txt = ./txt/cord-034746-uxhpufnv.txt === reduce.pl bib === id = cord-103686-er8llst4 author = Carboni Bisso, I. title = Influenza season 2019: analysis of 143 hospitalized cases date = 2020-09-18 pages = extension = .txt mime = text/plain words = 2426 sentences = 164 flesch = 50 summary = Among the patients hospitalized due to influenza severe respiratory infection, it has been estimated that 29 to 6% require admission to the intensive care unit (ICU). In Argentina, there is a significant absence of data regarding influenza severe respiratory disease and, therefore, a lack of knowledge about the impact of this disease at health institutions, hospital mortality, and the profile of patients requiring ICU. Thus, the objective of this work is to describe the history of comorbidities as well as the clinical, laboratory and imaging findings of patients who required hospitalization in a general ward or ICU during 2019 in a high-complexity care hospital from Buenos Aires, capital of Argentina. In this cohort study, we reported the clinical characteristics and risk factors associated with clinical outcomes in patients with laboratory-confirmed influenza who required hospitalization during 2019. cache = ./cache/cord-103686-er8llst4.txt txt = ./txt/cord-103686-er8llst4.txt === reduce.pl bib === id = cord-034898-zjfhpum2 author = Patangi, Sanjay Orathi title = Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective date = 2020-11-07 pages = extension = .txt mime = text/plain words = 7527 sentences = 448 flesch = 39 summary = title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in 'post-cardiotomy cardiogenic shock' — A review with an Indian perspective Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an important modality of managing post-cardiotomy cardiogenic shock with variable outcomes which would otherwise be universally fatal. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has gained popularity over the years as a 'bailout' option after conventional circulatory support methods have proved refractory in the operating room (OR)/intensive care unit (ICU). Long-term survival and major outcomes in post-cardiotomy extracorporeal membrane oxygenation for adult patients in cardiogenic shock Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation Clinical outcomes in patients after extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock: a single-centre experience of 92 cases cache = ./cache/cord-034898-zjfhpum2.txt txt = ./txt/cord-034898-zjfhpum2.txt === reduce.pl bib === id = cord-035024-kx9jfssi author = Elmelhat, Ahmed title = Comparison between Prophylactic versus Therapeutic Doses of Low-Molecular-Weight Heparin in Severely Ill Coronavirus Disease 2019 Patients in Relation to Disease Progression and Outcome date = 2020-10-26 pages = extension = .txt mime = text/plain words = 3189 sentences = 158 flesch = 49 summary = INTRODUCTION: The predominant coagulation abnormalities in patients with coronavirus disease 2019 (COVID-19) suggest a hypercoagulable state and are consistent with uncontrolled clinical observations of an increased risk of venous thromboembolism. CONCLUSION: Our results showed that use of prophylactic dose of enoxaparin might have some benefits compared to the therapeutic dose in terms of less duration of ICU and hospital stay, duration of oxygen support, need and duration of MV, and normalization of inflammatory markers. There was a significant difference between both study groups in enoxaparin duration, time to ferritin and Ddimer improvement, and the duration of MV and O 2 support duration, with longer duration among group 2 cases (therapeutic dose) compared to group 1 (prophylactic dose) in all the above-mentioned variables. Our study compared the effect of different dose regimens of the anticoagulant enoxaparin (prophylactic and therapeutic) that was administered to patients with severe COVID-19 infection, and we compared the clinical outcome as well as improvement in laboratory parameters in both groups. cache = ./cache/cord-035024-kx9jfssi.txt txt = ./txt/cord-035024-kx9jfssi.txt === reduce.pl bib === id = cord-032181-gmcugd8h author = Song, Jian-Xin title = Main Complications of AECHB and Severe Hepatitis B (Liver Failure) date = 2019-05-21 pages = extension = .txt mime = text/plain words = 51165 sentences = 2516 flesch = 37 summary = 3. Hepatorenal syndrome, which is characterized by renal failure, hemodynamic changes in arterial circulation and abnormalities in the endogenous vascular system, is a common clinical complication of end-stage liver disease, and one of the important indicators for the prognosis of patients with severe hepatitis. The latest report indicated that basic laboratory examinations for coagulation function testing in common use at present, such as PT, APTT, international normalized ratio (INR) etc., have little correlation with occurrence of gastrointestinal bleeding in these patients, thereby revealing the importance to search and pay close attention to those complicating disease upregulating bleeding risk, such as bacterial infection, renal failure, hemodynamic change after portal hypertension, dysfunction of endotheliocyte as well as macrophagocyte and so on [107] . cache = ./cache/cord-032181-gmcugd8h.txt txt = ./txt/cord-032181-gmcugd8h.txt === reduce.pl bib === id = cord-035067-ic843wr9 author = de Almeida, Joana Ferro Machado title = COVID-19 and the gastrointestinal tract: what do we already know? date = 2020-11-05 pages = extension = .txt mime = text/plain words = 5453 sentences = 336 flesch = 56 summary = Those infected may be asymptomatic, present typical symptoms (fever, dry cough and dyspnea), gastrointestinal symptoms (diarrhea, nausea, vomiting and abdominal pain) and viral RNA in stools. Information on country of origin, mean age, different comorbidities, typical symptoms (fever, cough, and dyspnea, among others), gastrointestinal symptoms (diarrhea, nausea, vomiting, and abdominal pain), and the presence of viral RNA in feces, when cited, were included in this study for analysis. (19) According to the descriptive, cross-sectional, multicenter study (three hospitals in Hubei, China) by Pan et al., with 204 patients, in which 107 were male, mean age of 52.91±15.98 years, 103 (50.5%) reported some gastrointestinal symptom, such as lack of appetite (81; 78.6%), diarrhea (35; 34.0%), vomiting (4; 3.9%), and abdominal pain (2; 1.9%). (26) Cipriano et al., conducted a systematic review with six studies of patients from China, which points to the possibility of SARS-CoV-2 infection in the gastrointestinal tract and fecal-oral transmission. cache = ./cache/cord-035067-ic843wr9.txt txt = ./txt/cord-035067-ic843wr9.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-034578-i9rdubix author = Vaschetto, Rosanna title = Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date = 2020-10-30 pages = extension = .txt mime = text/plain words = 3678 sentences = 206 flesch = 46 summary = AIM: We aim at characterising a large population of Coronavirus 19 (COVID-19) patients with moderate-to-severe hypoxemic acute respiratory failure (ARF) receiving CPAP outside intensive care unit (ICU), and ascertaining whether the duration of CPAP application increased the risk of mortality for patients requiring intubation. We designed this retrospective multicentre study to describe the clinical characteristics of patients with laboratory-confirmed COVID-19 treated with CPAP outside ICU, to assess 60-day in-hospital mortality, and hospital length of stay (LOS), and to ascertain whether the duration CPAP application prior to CPAP failure affects outcome in patients requiring endotracheal intubation. This multicentre retrospective observational study on 537 patients hypoxemic ARF secondary to laboratory-confirmed COVID-19 infection, shows that CPAP applied to different therapeutic goals i.e., candidate to intubation in the case of CPAP failure and do-not-intubate in which CPAP is considered the ceiling of treatment, is feasible outside ICU. cache = ./cache/cord-034578-i9rdubix.txt txt = ./txt/cord-034578-i9rdubix.txt === reduce.pl bib === === reduce.pl bib === id = cord-035026-2qcsfd87 author = Ugwueze, Chidiebere V. title = COVID-19 and Diabetes Mellitus: The Link and Clinical Implications date = 2020-10-23 pages = extension = .txt mime = text/plain words = 5413 sentences = 329 flesch = 44 summary = The effect of glucocorticoids and catecholamines, invasion of the pancreatic islet cells, drugs used in the treatment of COVID-19, and the lockdown policy may impact negatively on glycemic control of diabetic patients. [40] showed that the clinical outcomes in COVID-19-positive patients with coexisting diabetes and hypertension who use ACE inhibitor or angiotensin II receptor blocker were comparable to those not using the drugs. A clinical trial (NCT04318418) was designed to determine the effect of ACE inhibitors and angiotensin II type 1 receptor blockers on the severity of COVID-19 infection [41] . Some authors have considered the rapidity of worsening glycemic control in stable diabetic patients with CO-VID-19 requiring the use of high insulin dose and suggested the possibility of pancreatic invasion by the SARS-CoV-2 [57, 58] . Once the entry of the virus is established, there is a downregulation of ACE2 receptor and a corresponding Ugwueze/Ezeokpo/Nnolim/Agim/ Anikpo/Onyekachi Dubai Diabetes Endocrinol J 6 DOI: 10.1159/000511354 activation of renin-angiotensin-aldosterone system, which is responsible for the cardiac and pulmonary complications of COVID-19 infection [75] . cache = ./cache/cord-035026-2qcsfd87.txt txt = ./txt/cord-035026-2qcsfd87.txt === reduce.pl bib === === reduce.pl bib === id = cord-104055-47ren7ie author = Lutkenhoff, Evan S. title = EEG power spectra and subcortical pathology in chronic disorders of consciousness date = 2020-09-01 pages = extension = .txt mime = text/plain words = 2479 sentences = 127 flesch = 49 summary = Objective To determine (i) the association between long-term impairment of consciousness after severe brain injury, spontaneous brain oscillations, and underlying subcortical damage, and (ii) whether such data can be used to aid patient diagnosis, a process known to be susceptible to high error rates. Conclusions These results ground, for the first time, electroencephalographic presentation detected with routine clinical techniques in the underlying brain pathology of disorders of consciousness and demonstrate how multimodal combination of clinical, electroencephalographic, and imaging data can be employed in potentially mitigating the high rates of misdiagnosis typical of this patient cohort. Sex, 19 age, time-post-injury, etiology (i.e., TBI vs non-TBI), were included as covariates, 20 along with NBV (to ensure that observed tissue displacement reflect local subcortical 21 shape changes independent of overall brain atrophy ( In this analysis, we related the patients' behavioral presentation, as captured by the 7 CRS-R subscales, with subcortical atrophy. cache = ./cache/cord-104055-47ren7ie.txt txt = ./txt/cord-104055-47ren7ie.txt === reduce.pl bib === === reduce.pl bib === id = cord-102199-mc6zruyx author = Toksvang, Linea Natalie title = Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: a systematic review date = 2019-01-30 pages = extension = .txt mime = text/plain words = 2340 sentences = 144 flesch = 40 summary = title: Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: a systematic review Hepatotoxicity in the form of sinusoidal obstruction syndrome (SOS) occurred in 9–25% of the ALL patients in two of the four included RCTs using 6TG doses of 40–60 mg/m2/day, and long-term hepatotoxicity in the form of nodular regenerative hyperplasia (NRH) was reported in 2.5%. Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial 6-Thioguanine associated nodular regenerative hyperplasia in patients with inflammatory bowel disease may induce portal hypertension Splitting a therapeutic dose of thioguanine may avoid liver toxicity and be an efficacious treatment for severe inflammatory bowel disease: a 2-center observational cohort study Early nodular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapy cache = ./cache/cord-102199-mc6zruyx.txt txt = ./txt/cord-102199-mc6zruyx.txt === reduce.pl bib === id = cord-103214-3lz33pj3 author = Kortuem, S. O. title = The Role of the Emergency Department in Protecting the Hospital as a Critical Infrastructure in the Corona Pandemic Strategies and Experiences of a Rural Sole Acute-Care Clinic date = 2020-09-09 pages = extension = .txt mime = text/plain words = 4293 sentences = 263 flesch = 50 summary = An essential strategic element was a very short-term restructuring of the Emergency Department with the objectives of reducing the number of cases within the clinic, detecting COVID-19 cases as sensitively as possible and separating the patient pathways at an early stage. After establishing a pre-triage with structured algorithms, all confirmed COVID-19 cases were identified before entering the clinic and assigned to an appropriate treatment pathway. . https://doi.org/10.1101/2020.09.07.20185819 doi: medRxiv preprint As of March 27, 2020, a specially developed algorithm for case detection was established, which, in addition to broader range of clinical criteria, focuses on the regionally observable epidemiological events in risk facilities, e. 7%) of the patients, neither direct contact with confirmed COVID-19 cases nor a stay in high-risk areas or facilities could be recorded at the time of pre-triage ( Figure 6 ). At this point, the Emergency Department has the key function of identifying those patients who need treatment with the hospital resources for medical reasons and referring other cases to the outpatient sector. cache = ./cache/cord-103214-3lz33pj3.txt txt = ./txt/cord-103214-3lz33pj3.txt === reduce.pl bib === id = cord-102276-0a8hup5y author = Savage, R. S. title = Development and validation of multivariable machine learning algorithms to predict risk of cancer in symptomatic patients referred urgently from primary care date = 2020-10-27 pages = extension = .txt mime = text/plain words = 3792 sentences = 227 flesch = 57 summary = title: Development and validation of multivariable machine learning algorithms to predict risk of cancer in symptomatic patients referred urgently from primary care In use-case 1, the algorithms correctly identify 20% of patients who do not have cancer and may not need an urgent 2WW referral. 10 We report the development and validation of a set of machine learning algorithms to provide a calibrated risk probability of cancer (a score between zero and one, higher values indicating greater risk of cancer) for triaging symptomatic patients. Table 6 shows test performance characteristics for use-case 2 (triage), to identify patients at higher risk of cancer who would be considered for priority through the urgent referral pathway. This paper reports the development and validation of a set of statistical machine learning algorithms based on routine laboratory blood measurements that can predict cancer outcomes for symptomatic patients referred urgently from primary care for possible cancer diagnosis. cache = ./cache/cord-102276-0a8hup5y.txt txt = ./txt/cord-102276-0a8hup5y.txt === reduce.pl bib === id = cord-048343-nzk8m912 author = Milbrandt, Eric B title = Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics date = 2006-11-15 pages = extension = .txt mime = text/plain words = 5789 sentences = 283 flesch = 33 summary = A large number of pathophysiologic mechanisms are thought to underlie critical illness-associated cognitive dysfunction, including neuro-transmitter abnormalities and occult diffuse brain injury. Markers that could be used to evaluate the influence of specific mechanisms in individual patients include serum anticholinergic activity, certain brain proteins, and tissue sodium concentration determination via high-resolution three-dimensional magnetic resonance imaging. Many of the data supporting occult diffuse brain injury as a cause of critical illness-associated CD come from studies of sepsis and septic encephalopathy, a form of delirium. Lending support to the hypothesis that acute inflammation leads to brain injury and subsequent development of delirium, a recent study found that delirium in postoperative hipfractured patients was significantly associated with serum levels of C-reactive protein, an acute-phase protein that is a marker of acute inflammation [55] . Elevated serum S-100β levels were recently demonstrated in critically ill patients with respiratory failure [69] and in porcine models of endotoxic shock [70] and acute lung injury [71] . cache = ./cache/cord-048343-nzk8m912.txt txt = ./txt/cord-048343-nzk8m912.txt === reduce.pl bib === id = cord-104180-f3hoz9bu author = Kirk-Bayley, Justin title = Recently published papers: inflammation, elucidation, manipulation? date = 2003-07-03 pages = extension = .txt mime = text/plain words = 1548 sentences = 84 flesch = 42 summary = They looked at end-organ epithelial cell apoptosis in a rabbit model of ARDS and at the effects of plasma on epithelial cells from recipients of the injurious ventilatory strategy, and analyzed samples from a previous trial into lung protective ventilation [8] . Choosing the right ventilation strategy for ARDS patients has more benefits than just lung protection, and therapeutic targeting of these factors that induce end organ apoptosis may be the next step. Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study cache = ./cache/cord-104180-f3hoz9bu.txt txt = ./txt/cord-104180-f3hoz9bu.txt === reduce.pl bib === id = cord-035182-ax6v3ak5 author = Griebenow, Reinhard title = Outcomes in CME/CPD - Special Collection: How to make the “pyramid” a perpetuum mobile date = 2020-10-27 pages = extension = .txt mime = text/plain words = 2781 sentences = 165 flesch = 45 summary = To enhance the effect CME may achieve in improving community health the authors suggest a kick-off/keep-on continuum of medical competence, and integration of aspects of public health at all levels from planning to delivery and outcomes measurement in CME. Continuing medical education (CME) should not be an end in itself, but as expressed in Moore's pyramid [1] , help to improve both individual patient and ultimately community health. Continuing medical education (CME) should not be an end in itself, but as expressed in Moore's pyramid [1] , help to improve both individual patient and ultimately community health. On the one hand there is some evidence for the impact of this strategy on physician performance and patient outcomes [82] , but on the other hand this is not the appropriate strategy to address gaps in community health, and tends to create an attitude of unbalanced activism. The impact of CME on physician performance and patient health outcomes: an updated synthesis of systematic reviews cache = ./cache/cord-035182-ax6v3ak5.txt txt = ./txt/cord-035182-ax6v3ak5.txt === reduce.pl bib === id = cord-104507-xx7t26rl author = Safari, Saeid title = Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Severe COVID-19 patients; a Narrative Review date = 2020-08-22 pages = extension = .txt mime = text/plain words = 3425 sentences = 173 flesch = 31 summary = Based on previous experience of blood purification to treat cytokine storm syndrome (CSS) in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), here we aimed to review the current literature on extracorporeal hemoperfusion as a potential therapeutic option for CSS-associated conditions, with a focus on severe COVID-19. To date, various centers in different countries including Italy, China, USA, Germany, and Iran have reported or are investigating the beneficial effects of different hemoperfusion systems, including HA380/HA330 cartridges, CytoSorb, and polymyxin B immobilized fiber column in treatment of critically-ill COVID-19 patients. To date, a large number of experimental and clinical data, mostly from case reports and case series, have introduced CytoSorb as an effective rescue therapy for removal of inflammatory cytokines and achievement of hemodynamic stabilization in critically ill patients with septic shock and kidney failure (47) (48) (49) . cache = ./cache/cord-104507-xx7t26rl.txt txt = ./txt/cord-104507-xx7t26rl.txt === reduce.pl bib === === reduce.pl bib === id = cord-184194-zdxebonv author = Chen, Lichin title = Using Deep Learning and Explainable Artificial Intelligence in Patients' Choices of Hospital Levels date = 2020-06-24 pages = extension = .txt mime = text/plain words = 4915 sentences = 270 flesch = 47 summary = This study used nationwide insurance data, accumulated possible features discussed in existing literature, and used a deep neural network to predict the patients choices of hospital levels. Focusing on the hospital levels of the patients' choices, this study used explainable artificial intelligence (XAI) methods to interpret the effecting features for the general public and individuals. According to a public opinion poll conducted in 2019 [35] , although 85.3% of the respondents agreed that for a mild condition the patient should go to the primary care service nearby instead of tertiary hospitals, 70% considered institutes with higher levels to possess better professional skills, and 49% expressed having confidence in determining the severity of their own condition. According to our result, three features could interpret the majority of patients' choices of hospital levels: the MFPC, LFPC, and physician density. cache = ./cache/cord-184194-zdxebonv.txt txt = ./txt/cord-184194-zdxebonv.txt === reduce.pl bib === === reduce.pl bib === id = cord-103807-x4hrwhkz author = Prokop, J. W. title = Viral Induced Genetics Revealed by Multi-Dimensional Precision Medicine Transcriptional Workflow date = 2020-04-06 pages = extension = .txt mime = text/plain words = 6843 sentences = 375 flesch = 50 summary = Patients often present to the intensive care unit with broad phenotypes, including multiple organ dysfunction syndrome (MODS) resulting from infection, trauma, or other disease processes. Using multi-time point whole blood (cellular/acellular) total transcriptomics in 27 patients, we highlight the promise of simultaneously mapping viral/bacterial load, cell composition, tissue damage biomarkers, balance between syndromic biology vs. The power of RNA generated data likely is in its potential to effect therapeutic changes in individual patients with diverse clinical presentations, such as Multiple Organ Dysfunction Syndrome (MODS). Additional insights from the top mapped bacteria include normal flora elevation of Polynucleobacter necessarius and Bordetella parapertussis in patient 24 suggested to have issues in antigen processing and presentation (case study presented below for RNASEH2B), multiple Streptococcus strains (including pyogenes) identified in patients 11 and 5 that were culture positive, Pandoraea faecigallinarum in patient 10, and Cryobacterium arcticum in patient 10 day 0. cache = ./cache/cord-103807-x4hrwhkz.txt txt = ./txt/cord-103807-x4hrwhkz.txt === reduce.pl bib === id = cord-217201-lvefk7qx author = Wang, Yang title = Ontology-based annotation and analysis of COVID-19 phenotypes date = 2020-08-05 pages = extension = .txt mime = text/plain words = 2483 sentences = 147 flesch = 46 summary = Based on the HP classification, we systematically analyze three nervous phenotypes (loss of smell, loss of taste, and headache) and four abdominal phenotypes (nausea, vomiting, abdominal pain, and diarrhea) identified in patients, and found that patients from Europe and USA turned to have higher nervous phenotypes and abdominal phenotypes than patients from Asia. First, we analyzed the group of COVID-19-related nervous system phenotypes, which includes loss of smell (anosmia), loss of taste (parageusia), and headache ( Figure 1 ). To further study the relation between different comorbidity phenotypes and disease outcomes, we survey the disease data from the literature and compared the incidences of specific comorbidity phenotypes in severe or non-severe COVID-19 patients. In severe disease patients, the incidence of diabetes or kidney failure was higher than that in non-severe patient groups (The X-axis is country/city, report date, number of cases). Based on the HP classification, we systematically analyzed 17 clinical phenotypes of COVID-19 in case reported. cache = ./cache/cord-217201-lvefk7qx.txt txt = ./txt/cord-217201-lvefk7qx.txt === reduce.pl bib === === reduce.pl bib === id = cord-035396-lg7m9xzs author = Bains, Amarpreet S. title = Maintaining Throughput and Reducing Discharge Delays After Increasing Capacity During The Covid-19 Pandemic: A New York City Hospital’s Experience date = 2020-11-12 pages = extension = .txt mime = text/plain words = 2401 sentences = 105 flesch = 49 summary = A command center for coordinating discharges and a streamlined process for arranging home oxygen helped a New York hospital significantly speed up discharges during the Covid-19 pandemic with no negative impact on readmissions. Our second step was to have our Social Work and Case Management departments work closely with our largest DME vendor (who provides over 90% of all oxygen and medical equipment for our patients) to streamline the process for discharging patients home with supplemental oxygen, a process that has historically extended hospitalizations by an entire day or more. We attribute this improvement to: better communication between unit managers and discharge control center; earlier identification of barriers; on-site representative for home oxygen; streamlining of the documentation and authorization processes; providers learning how to optimize documentation; and time saved by many patients not requiring home delivery. cache = ./cache/cord-035396-lg7m9xzs.txt txt = ./txt/cord-035396-lg7m9xzs.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-158252-l43ztxsl author = Pawlowski, Colin title = Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures date = 2020-05-21 pages = extension = .txt mime = text/plain words = 6126 sentences = 221 flesch = 35 summary = We found that compared to COVIDneg at the time of clinical presentation and diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and similarly low platelet counts, with approximately 25% of patients in both cohorts showing outright thrombocytopenia. To this end, we instituted a holistic data science platform across an academic health care system that enables machine intelligence to augment the curation of phenotypes and outcomes from 15.2 million EHR clinical notes and associated 3 million lab tests from 1,192 COVID-19positive (COVIDpos) and 47,344 confirmed COVID-19-negative (COVIDneg) patients over a retrospectively defined 2-month observation period straddling the date of the PCR test (see Methods). Conversely, platelet counts were lower in the COVIDpos cohort at the time of clinical presentation but tended to increase over the subsequent 10 days to levels significantly higher than those in COVIDneg patients (Cohen's D = 0.361, BH-adjusted Mann-Whitney p-value = 0.008, Table 2, Figure 2B ). cache = ./cache/cord-158252-l43ztxsl.txt txt = ./txt/cord-158252-l43ztxsl.txt === reduce.pl bib === id = cord-204125-fvd6d44c author = Chowdhury, Muhammad E. H. title = An early warning tool for predicting mortality risk of COVID-19 patients using machine learning date = 2020-07-29 pages = extension = .txt mime = text/plain words = 3883 sentences = 199 flesch = 47 summary = Lactate dehydrogenase, neutrophils (%), lymphocyte (%), high sensitive C-reactive protein, and age acquired at hospital admission were identified as key predictors of death by multi-tree XGBoost model. The prognostic model, nomogram and LNLCA score can help in early detection of high mortality risk of COVID-19 patients, which will help doctors to improve the management of patient stratification. [21] reported a machine learning approach to select three biomarkers (lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP)) and using them to predict individual patients mortality, 10 days ahead with more than 90 percent accuracy. Although several predictive prognostic models are proposed for the early detection of individuals at high risk of COVID-19 mortality, a major gap remains in the design of state-of-the-art interpretable machine learning based algorithms and high performance quantitative scoring system to classify the most selective predictive biomarkers of patient death. cache = ./cache/cord-204125-fvd6d44c.txt txt = ./txt/cord-204125-fvd6d44c.txt === reduce.pl bib === id = cord-216974-0al3vdh1 author = Ravaud, Philippe title = Reconfiguring health services to reduce the workload of caregivers during the COVID-19 outbreak using an open-source scalable platform for remote digital monitoring and coordination of care in hospital Command Centres date = 2020-03-12 pages = extension = .txt mime = text/plain words = 1459 sentences = 90 flesch = 52 summary = title: Reconfiguring health services to reduce the workload of caregivers during the COVID-19 outbreak using an open-source scalable platform for remote digital monitoring and coordination of care in hospital Command Centres Patients answer simple self-reported questionnaires and their data is transmitted, in real time, to a Command Centre in the nearest reference hospital. Data from remote monitoring of patients are transmitted to a Command Centre, in the nearest reference hospital, and automated algorithms triage patients with early warning signs. Patients with confirmed Covid-19 are assessed by clinicians (in hospital or in community) for: 1) absence of initial signs of severity (based on their age, comorbidities, initial presentation of the disease); 2) their ability to be quarantined at home (e.g., absence of a psychiatric disorder or of a loss of autonomy); and 3) their ability to perform the remote monitoring at home (e.g., basic computer literacy, smartphone availability). cache = ./cache/cord-216974-0al3vdh1.txt txt = ./txt/cord-216974-0al3vdh1.txt === reduce.pl bib === id = cord-103659-wpwfqhp2 author = Almqvist, J. title = Neurological manifestations of coronavirus infections: a systematic review date = 2020-09-01 pages = extension = .txt mime = text/plain words = 6075 sentences = 463 flesch = 46 summary = In order to optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we systematically reviewed neurological and neuroradiological manifestations of SARS-CoV-2 and all other known human coronavirus species (HCoV). . https://doi.org/10.1101/2020.08.26.20182196 doi: medRxiv preprint symptoms/complications, neuropathological findings and/or neuroimaging findings associated to acute or prior coronavirus infection. Several case reports, comprising a total of 11 patients, described neurological complications in SARS-CoV-1, among them critical illness neuro-/myopathy, seizures, persistent sleeping difficulties, persistent anosmia, delirium and generalized pain (Table e-6). Several common neurological symptoms among SARS-CoV-2 patients have been described in these studies, such as fatigue (44 -64% of patients), 42 is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint Retrospective Observational Study of Brain Magnetic Resonance Imaging Findings in Patients with Acute SARS-CoV-2 Infection and Neurological Manifestations cache = ./cache/cord-103659-wpwfqhp2.txt txt = ./txt/cord-103659-wpwfqhp2.txt === reduce.pl bib === id = cord-252159-6t35bxwv author = Ferraù, F. title = What we have to know about corticosteroids use during Sars-Cov-2 infection date = 2020-08-28 pages = extension = .txt mime = text/plain words = 5201 sentences = 237 flesch = 31 summary = PURPOSE: Glucocorticoids (GCs), alone or associated to other drugs, were widely used in the management of patients affected by severe acute respiratory syndrome caused by SARS-CoV-2 infection, during the recent COVID-19 outbreak. RESULTS: GC treatment can cause symptoms of hypercortisolism, especially in patients with individual hypersensibility, or hypoadrenalism after drug withdrawal, due to hypothalamic–pituitary–adrenal (HPA) axis suppression, with consequences in terms of increased morbidity and mortality risk. On the other hand, prolonged steroids treatment can cause symptoms of hypercortisolism, especially in patients with individual hypersensibility, or hypoadrenalism after drug withdrawal, due to hypothalamic-pituitary-adrenal (HPA) axis suppression. This review summarizes the available data on HPA axis impairment in GC-treated Sars-Cov2 patients, focusing on the risk of adrenal insufficiency and on potential drug interactions during concomitant treatments. This review summarizes the available data on HPA axis impairment in GC-treated Sars-Cov2 patients, focusing on the risk of adrenal insufficiency and on potential drug interactions during concomitant treatments. cache = ./cache/cord-252159-6t35bxwv.txt txt = ./txt/cord-252159-6t35bxwv.txt === reduce.pl bib === id = cord-252617-rqm0p19e author = Baker, Paul A. title = What’s inside the box? Or shall we think outside the box? date = 2020-08-28 pages = extension = .txt mime = text/plain words = 827 sentences = 53 flesch = 48 summary = With the deadly and highly transmissible SARS-CoV-2 virus causing the COVID-19 pandemic, there is global concern about the danger of contaminating healthcare workers (HCW), particularly during airway management of infected patients. In this edition of Pediatric Anesthesia, Bryant and Tobias report a laboratory study where there was up to 99.2% decrease of artificial aerosol particles measured outside compared with inside an enclosed clear intubation box using augmented gas flow (suction). 1 At first glance, the concept of a barrier over the patient during airway management seems like a simple and logical option in terms of protecting practitioners from viral infection. Intubation is reported to be a high-risk procedure for aerosol release and transmission of infection to HCWs. Supporting evidence for this comes from a systematic review. The aerosol box for intubation in COVID-19 patients: an in-situ simulation crossover study cache = ./cache/cord-252617-rqm0p19e.txt txt = ./txt/cord-252617-rqm0p19e.txt === reduce.pl bib === === reduce.pl bib === id = cord-252829-gn56tsz3 author = Higginson, Irene J. title = Associations between informal care costs, care quality, carer rewards, burden and subsequent grief: the international, access, rights and empowerment mortality follow-back study of the last 3 months of life (IARE I study) date = 2020-11-03 pages = extension = .txt mime = text/plain words = 5791 sentences = 311 flesch = 57 summary = title: Associations between informal care costs, care quality, carer rewards, burden and subsequent grief: the international, access, rights and empowerment mortality follow-back study of the last 3 months of life (IARE I study) Data: ICrs reported hours and activities, care quality, positive aspects and burdens of caregiving, and completed the Texas Revised Inventory of Grief (TRIG). Multivariable logistic regression analysis explored the association of potential explanatory variables, including IC costs and care quality, on three outcomes: positive aspects and burdens of caregiving, and subsequent grief. Therefore, as part of the International, Access, Rights, and Empowerment (IARE I) study of palliative care in three countries, we aimed to determine and compare the informal care (IC) costs and their associations with selfreported caregiver burden, rewards and subsequent caregiver grief, taking account of care quality, as reported by ICrs. We conducted a mortality follow-back postal survey of key informants (normally relatives and informal carers) of decedents identified by palliative care services in participating hospitals. cache = ./cache/cord-252829-gn56tsz3.txt txt = ./txt/cord-252829-gn56tsz3.txt === reduce.pl bib === id = cord-252473-i4pmux28 author = Rogers, Sharon title = Why can't I visit? The ethics of visitation restrictions – lessons learned from SARS date = 2004-08-31 pages = extension = .txt mime = text/plain words = 1908 sentences = 83 flesch = 42 summary = It could be argued that visitation restrictions, in light of a potential outbreak of a contagious disease, are ethically sound because of the compelling need to protect public health. In a health care institution, visitation restrictions not only affect inpatients but also have an impact on ambulatory patients who must come for diagnostic tests or interventions and who, if deprived access, might develop urgent or emergent conditions. Furthermore, to be consistent with expectations of transparency, the criteria by which exceptionality to the rules of visitation restriction exists should also be published openly throughout the organization for staff, patients and visitors. For example, although current policy allows for specific times of visitation and numbers of visitors per day, a sudden outbreak might dictate a quick lockdown of the facility without patients or family members receiving prior notice. It is ethical to accept that public health protection trumps individual rights to liberal visitation. cache = ./cache/cord-252473-i4pmux28.txt txt = ./txt/cord-252473-i4pmux28.txt === reduce.pl bib === === reduce.pl bib === id = cord-252013-ehyuflg3 author = Bozzani, Antonio title = ACUTE ARTERIAL AND DEEP VENOUS THROMBOEMBOLISM IN COVID-19 PATIENTS date = 2020-09-22 pages = extension = .txt mime = text/plain words = 2533 sentences = 127 flesch = 45 summary = AIM: Our aim was to report the experience of the Department of Vascular Surgery of Pavia (Lombardy), including the lessons learned and future perspectives regarding the management of COVID-19 patients who developed severe acute ischemia with impending lower limb loss or deep vein thrombosis (DVT). CONCLUSIONS: Our study confirms that critically ill, COVID-19 patients who develop arterial and deep vein thrombosis are at high risk of mortality, but if treated properly, there is an improvement in overall survival rate, especially in patients of 60 years of age or younger. The aim of our analysis was to report our experience of the Department of Vascular Surgery of Pavia (Lombardy), focusing on the lessons learned and future perspectives regarding the management of COVID-19 patients who developed severe acute ischemia with impending lower limb loss or deep vein thrombosis (DVT). cache = ./cache/cord-252013-ehyuflg3.txt txt = ./txt/cord-252013-ehyuflg3.txt === reduce.pl bib === id = cord-251957-luw8m3eq author = Griffin, Claire L. title = Aortic Disease in the Time of COVID: Repercussions on Patient Care at an Academic Aortic Center date = 2020-04-30 pages = extension = .txt mime = text/plain words = 1402 sentences = 76 flesch = 50 summary = Here we describe the modifications we have implemented in clinical care provided by the 8 multidisciplinary Aortic Disease Program at our large regional referral institution to address the 9 challenges presented by the COVID-19 pandemic. Unfortunately given the rapid escalation of this worldwide pandemic, we do not 19 have the luxury of waiting for definitive data regarding the effects of COVID-19 on the 20 cardiovascular system-we must proceed in the face of this uncertainty to continue to take care 21 of patients. We have also considered altering our operative plan for patients with aortic disease in need of 13 high-risk operations to take into consideration the current and projected constrained resources of 14 our hospital system due to the pandemic. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During 17 the Coronavirus Disease 2019 (COVID-19) Pandemic cache = ./cache/cord-251957-luw8m3eq.txt txt = ./txt/cord-251957-luw8m3eq.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-252279-0gozdv43 author = Pal, Amit title = Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update date = 2020-06-10 pages = extension = .txt mime = text/plain words = 3858 sentences = 207 flesch = 39 summary = Without a therapeutic vaccine or specific antiviral drugs, and with a desperate attempt to find a cure against novel Corona Virus Disease 2019 (Covid-19) [1] , the limelight was shifted to hydoxychloroquine (derivative of chloroquine that has antimalarial, antiinflammatory, immunosuppressive and antiautophagy activities [2, 3] ; upon a tweet by US president Mr. Donald J. The main aim of this review is to discuss the mode of action of hydroxychloroquine at cellular and molecular levels, that potentially support the clinical efficacy and few adverse side effects observed in Covid-19 patients treated with hydroxychloroquine, which may further help in improving the clinical outcomes by modifying or altering the drug itself or its restricted use in certain individuals by enforcing strict inclusion and exclusion criteria. Due to its cellular and molecular effects as discussed in previous sections, quite a few clinical trials are studying the effectiveness and safety of hydroxychloroquine (also chloroquine) for Covid-19 (https://clinicaltrials.gov/ct2/ results?cond=%22wuhan?coronavirus%22). cache = ./cache/cord-252279-0gozdv43.txt txt = ./txt/cord-252279-0gozdv43.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-252284-cgdcsazr author = Zeng, Jia-Hui title = First case of COVID-19 complicated with fulminant myocarditis: a case report and insights date = 2020-04-10 pages = extension = .txt mime = text/plain words = 1988 sentences = 124 flesch = 50 summary = CONCLUSION: COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. Bedside echocardiography showed an enlarged left ventricle (61 mm), diffuse myocardial dyskinesia along with a low left ventricular ejection fraction (LVEF) (32%), pulmonary hypertension (44 mmHg), and no decrease in right cardiac function (Figs. Recently published COVID-19 studies have shown that cardiac complications, including heart failure, arrhythmia and myocardial infarction, are not uncommon, and the proportion of people with increased Trop I in severe cases is higher than other cases [3, 4] . In this case, the patient had the following features: sudden onset, obvious symptoms of viral infection, rapid emergence of severe hemodynamic disorders, severe myocardial injury, and diffuse decreased ventricular wall movement. In this case, the patient had no history of heart disease; therefore, the decreased cardiac function was likely to be caused by COVID-19. COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. cache = ./cache/cord-252284-cgdcsazr.txt txt = ./txt/cord-252284-cgdcsazr.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-252687-7084pfqm author = Szelenberger, Rafal title = Ischemic Stroke among the Symptoms Caused by the COVID-19 Infection date = 2020-08-19 pages = extension = .txt mime = text/plain words = 7334 sentences = 378 flesch = 37 summary = Many clinical studies have shown an association between SARS-CoV-2 infection and hypercoagulability diagnosed on the basis of abnormal coagulation parameters, including activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer and C-reactive protein level. In this review, the potential mechanism and the effect of the SARS-CoV-2 viral infection on the development of ischemic stroke in COVID-19 patients were carefully studied. study, in which most non-survivor COVID-19 patients' (71.4%) blood tests showed prolonged prothrombin time and an increased D-dimer levels, which indicated the state after activation of the plasma coagulation system [14] . The accumulation of immune cells in the vascular wall in response to the viral infection, especially among patients with ischemic risk factors, induces endothelial dysfunction, migration and proliferation of cells, activation of coagulation cascade and production of fibrous plaques. cache = ./cache/cord-252687-7084pfqm.txt txt = ./txt/cord-252687-7084pfqm.txt === reduce.pl bib === === reduce.pl bib === id = cord-252452-wwkw1uyi author = Rossi, Rosario title = Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action date = 2020-10-03 pages = extension = .txt mime = text/plain words = 1331 sentences = 79 flesch = 47 summary = As a further analysis, to investigate whether the intensity of action of statins could influence the risk of mortality, we divided our 42 patients taking statins into two subgroups, based on the drug's intensity of action, according to the ACC/AHA Classification [5] . The comparison between the survival curves, in contrast to patients who did not take statins, showed no significant differences (Fig. 1b) . The comparison between the survival curves, in contrast to patients who did not take statins, indicated a significant difference between groups. In a recent study, no significant differences in statin chronic assumption were found in COVID-19 patients who developed a cardiac injury, even if this population showed an increased mortality risk in the brief period [11] . The comparison between the survival curves, in contrast to patients who did not take statins, showed no significant differences. The comparison between the survival curves, in contrast to patients who do not take statins, showed a significant differences role against the virus. cache = ./cache/cord-252452-wwkw1uyi.txt txt = ./txt/cord-252452-wwkw1uyi.txt === reduce.pl bib === id = cord-104404-ytszpa4c author = Baig, Muhammad Akbar title = The COVID-19 Intubation and Ventilation Pathway (CiVP); a Commentary date = 2020-03-25 pages = extension = .txt mime = text/plain words = 654 sentences = 49 flesch = 50 summary = authors: Baig, Muhammad Akbar In wake of the current COVID-19 pandemic, which has taken the world by storm, it is imperative to protect the health and safety of physicians and staff involved in acute management of COVID-19 patients. As of now, it is essential to contain a crashing suspected/confirmed COVID-19 patient within the confines of a negative isolation chamber due to a high risk of aerosolization, with strict adherence to personal protective equipment (PPE), exclusively comprising of N95 or preferably a powered air purifying respirator (PAPR) (1). The ARDSnet (acute respiratory distress syndrome network) protocol should be followed for patient ventilation. Following intubation and initial ventilation, immediately proceed to transfer the patient to intensive care unit, after which, perform decontamination of the initial zone and the equipment used. Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease Prone Positioning in Severe Acute Respiratory Distress Syndrome cache = ./cache/cord-104404-ytszpa4c.txt txt = ./txt/cord-104404-ytszpa4c.txt === reduce.pl bib === id = cord-253168-b095rq5i author = Jiménez-Blanco Bravo, Marta title = Heart Failure in the Time of COVID-19 date = 2020-06-26 pages = extension = .txt mime = text/plain words = 1304 sentences = 66 flesch = 54 summary = OBJECTIVE: The aim of this study was to evaluate the results of a follow-up protocol established in an advanced heart failure unit at a single center in Spain during the coronavirus disease 2019 (COVID-19) pandemic. RESULTS: When compared to the preceding months, during the COVID pandemic there was a 56.5% reduction in the ER visits and a 46.9% reduction in hospital admissions, without an increase in mortality (9 patients died in both time periods). CONCLUSION: Our study suggests that implementing an active-surveillance protocol in acutely decompensated heart failure units during the SARS-CoV-2 pandemic can reduce hospital admissions, ER visits and, potentially, viral transmission, in a cohort of especially vulnerable patients. Our study suggests that implementing an active-surveillance protocol in HFUs during the SARS-CoV-2 pandemic can reduce hospital admissions, ER visits and, potentially, viral transmission, in a cohort of especially vulnerable patients. cache = ./cache/cord-253168-b095rq5i.txt txt = ./txt/cord-253168-b095rq5i.txt === reduce.pl bib === id = cord-252531-i3b647wv author = Song, Zaiwei title = Hospital pharmacists’ pharmaceutical care for hospitalized patients with COVID-19: Recommendations and guidance from clinical experience date = 2020-04-03 pages = extension = .txt mime = text/plain words = 3531 sentences = 180 flesch = 31 summary = Results Hospital pharmacists shall support pharmaceutical care services by participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, providing strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy, providing emotional counselling and psychological support, and providing scientific information about COVID-19 vaccines. For COVID-19 patients receiving centralized hospitalized treatment, pharmaceutical care services are https://doi.org/10.1016/j.sapharm.2020.03.027 Received 31 March 2020; Accepted 31 March 2020 indispensable supplement for clinical treatment and management, which is of great significance for improving the level of drug therapy, improving patient's outcome and promoting the overall pandemic control. Based on the Chinese perspective of "centralizing COVID-19 patients and centralized inpatient treatment", the paper established a pharmaceutical care framework of COVID-19 hospitalized patients, including participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy (CPT), providing emotional counselling and psychological support and providing scientific information about COVID-19 vaccines. cache = ./cache/cord-252531-i3b647wv.txt txt = ./txt/cord-252531-i3b647wv.txt === reduce.pl bib === id = cord-252085-8dq3gdo8 author = Kaisy, Dr. Maythem Abdulhassan Al title = Chest Drain Insertion following Pneumothorax due to CPR in a COVID – 19 Patient. date = 2020-08-14 pages = extension = .txt mime = text/plain words = 1157 sentences = 77 flesch = 50 summary = title: Chest Drain Insertion following Pneumothorax due to CPR in a COVID – 19 Patient. Chest Drain Insertion following Pneumothorax due to CPR in a COVID -19 Patient. Thus, in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection lungs are fragile and especially those with positive pressure ventilations, the dangers of pneumothorax arise, and comprehensive management is warranted. A 42 years old male patient was transferred to our hospital, intubated on mechanical ventilation, he had a 1 week history of fever, cough and shortness of breath, with positive PCR test for COVID-19, and CT scan showing extensive bilateral multiple, multilobed ground glass appearance with areas of consolidation, there was no given history of previous lung diseases or smoking history ( Figure 1 ). A portable chest x-ray was ordered, and the patient was found to have significant amount of left sided -pneumothorax with underlying lung collapse , mild mediastinal shift to the right side, with progressive course regarding the right side opacities (Figure 2 ), compared to previous x-ray. cache = ./cache/cord-252085-8dq3gdo8.txt txt = ./txt/cord-252085-8dq3gdo8.txt === reduce.pl bib === id = cord-252243-ua2w6xki author = Cooper, Emily title = Diagnosis and Management of UTI in Primary Care Settings—A Qualitative Study to Inform a Diagnostic Quick Reference Tool for Women Under 65 Years date = 2020-09-07 pages = extension = .txt mime = text/plain words = 8711 sentences = 509 flesch = 57 summary = Results: Staff were very aware of common UTI symptoms and nitrofurantoin as first-line treatment, but some were less aware about when to send a urine culture, second-line and non-antibiotic management, and did not probe for signs and symptoms to specifically exclude vaginal causes or pyelonephritis before prescribing. • Clearly outlines how to clinically assess someone with suspected UTI; • Includes prompts/considerations around differential diagnosis, pyelonephritis, and sepsis; • Clearly outlines the steps for clinical assessment of someone with suspected UTI and when a urine dipstick test or culture is needed; • Provides information on the sensitivity and specificity when using urine dipsticks to diagnose a UTI for women under 65 years; • Has been developed as an update to previous guidance; • Links to latest national guidance on antimicrobial prescribing for UTI management (developed since this study was conducted); • Links to UTI leaflets and resources for women under 65 years that explains evidenced-based prevention and self-care recommendations. cache = ./cache/cord-252243-ua2w6xki.txt txt = ./txt/cord-252243-ua2w6xki.txt === reduce.pl bib === id = cord-253148-3t4o27xp author = Chow, Brian D.W. title = Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio date = 2008-09-19 pages = extension = .txt mime = text/plain words = 2700 sentences = 200 flesch = 50 summary = STUDY DESIGN: From October 2005 through October 2006, we screened respiratory samples from children and adults negative for common respiratory pathogens for HBoV by PCR. CONCLUSIONS: HBoV circulates in Cleveland, OH, in children and adults with similar frequencies, and can warrant hospitalization and intensive care. We sought to further define the clinical and epidemiologic characteristics of HBoV in adult and pediatric patients in Cleveland, OH. Isolates positive for HBoV were screened for common respiratory viruses by RT-PCR with published primer sets. Forty samples (2.2%) tested positive for HBoV by PCR: 36 (90%) pediatric patients and 4 (10%) adult patients. Of pediatric patients who screened positive for HBoV, 27 (84.4%) were admitted to the hospital, including 9 (28.1%) who required intensive care. However, this report suggests that clinical disease associated with HBoV alone may be severe enough to require admission to the hospital in both adults and children and to the intensive care unit in children. cache = ./cache/cord-253148-3t4o27xp.txt txt = ./txt/cord-253148-3t4o27xp.txt === reduce.pl bib === id = cord-252699-0xw9xvox author = de Marcaida, Joy Antonelle title = Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) among Patients at a Movement Disorders Center date = 2020-09-18 pages = extension = .txt mime = text/plain words = 3438 sentences = 151 flesch = 42 summary = Second, we reviewed Hartford HealthCare's EHR to identify patients with Parkinson disease who were admitted for COVID-19 to any of our six affiliate hospitals across the state as a way to estimate the burden of COVID-19 on the population of patients with movement disorders. Of the patients who died, twelve (92%) were greater than 60 years old, eleven (85%) had parkinsonism, eleven (85%) were from an extended care facility, nine (69%) had comorbid dementia, nine (69%) had at least one high-risk comorbid condition, eight (62%) had alteration in mental status as a presenting symptom, and eight (62%) received a medication with antiviral properties (hydroxychloroquine, oseltamivir, amantadine, and memantine), including three who were on an adamantane prior to contracting COVID-19. Within our cohort of patients with movement disorders, factors related to increased mortality were age over 60 years, PD or parkinsonism diagnosis, residing in an extended care facility, comorbid dementia, and comorbid medical conditions. cache = ./cache/cord-252699-0xw9xvox.txt txt = ./txt/cord-252699-0xw9xvox.txt === reduce.pl bib === id = cord-253456-u9num2o9 author = Zhang, Che title = Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series date = 2020-06-16 pages = extension = .txt mime = text/plain words = 4540 sentences = 260 flesch = 49 summary = Suspected patients with clinical and/or radiological features of pneumonia were quarantined prior to SARS-CoV-2 nucleic acid detection according to WHO guidelines for cases with suspected infection [8] as well as the instructions from the Pediatric Branch of the Hubei Medical Association for pediatric cases [9] . Specifically, suspected cases of SARS-CoV-2 infection should meet 1 of the following criteria [10] : (1) at least 1 clinical symptom, including fever, expectation, tachypnea, lethargy, poor feeding, cough, vomiting, and diarrhea; (2) chest radiologic abnormalities consistent with viral pneumonia. Patients were discharged when all the following criteria were met [10] : (1) fever had recovered for at least 3 days; (2) upper respiratory symptoms were alleviated; (3) the exudative lesion was alleviated significantly according to radiological evidence; (4) negative results were obtained for SARS-CoV-2 nucleic acid detection in 2 consecutive tests performed with an interval of 24 hours. cache = ./cache/cord-253456-u9num2o9.txt txt = ./txt/cord-253456-u9num2o9.txt === reduce.pl bib === id = cord-252751-prock3co author = Kalligeros, Markos title = Remdesivir Use Compared to Supportive Care in Hospitalized Patients with Severe COVID-19: A Single-Center Experience date = 2020-08-06 pages = extension = .txt mime = text/plain words = 3948 sentences = 238 flesch = 55 summary = To be considered eligible for trial inclusion, patients had to meet the following criteria: 1) Currently hospitalized, aged ≥ 18 years, 2) SARS-CoV-2 infection confirmed by PCR test ≤ 4 days before trial enrollment 3) SpO2 ≤ 94% on room air or requiring supplemental oxygen at screening 4) Presence of radiographic evidence of pulmonary infiltrates. For each patient we extracted the following information: age, sex, race, ethnicity, days from onset of symptoms, imaging results, weight, vital signs and laboratory values (both on admission and during hospitalization), preexisting medical conditions, admission to the intensive care unit (ICU), use of mechanical ventilation, use of systemic corticosteroids [12] , hospitalization outcome (death or discharge) and incidence of acute kidney injury (AKI) using the KDIGO criteria [13] . In order to provide a cohesive assessment of the efficacy of remdesivir, we compared the clinical outcomes of patients who were hospitalized with severe COVID-19 (requiring supplemental oxygen and having abnormal imaging findings) and received either remdesivir or supportive care. cache = ./cache/cord-252751-prock3co.txt txt = ./txt/cord-252751-prock3co.txt === reduce.pl bib === id = cord-254148-wc762p6v author = Prell, Tino title = Recommendations for Standards of Network Care for Patients with Parkinson’s Disease in Germany date = 2020-05-13 pages = extension = .txt mime = text/plain words = 5349 sentences = 267 flesch = 41 summary = title: Recommendations for Standards of Network Care for Patients with Parkinson's Disease in Germany Thus, one recommendation for standard of care in the initial phase of the disease course is physician awareness of the first signs of PD (which could be achieved with better information and secondary prevention standards in the network) and early referral of patients to a movement disorder specialist (which could be achieved by specific disease management programmes). For these patients, at the border between inpatient and outpatient care and the need for sophisticated treatment strategies, the new comprehensive, individual, and interdisciplinary concept of a PD day clinic has proven to be effective [25] . In general, a neurologist should be responsible for long-term medical care of patients with PD, and movement disorder specialists should be involved when there is a special issue. cache = ./cache/cord-254148-wc762p6v.txt txt = ./txt/cord-254148-wc762p6v.txt === reduce.pl bib === id = cord-252890-of29g89s author = Villarreal-Fernandez, Eduardo title = A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure date = 2020-06-12 pages = extension = .txt mime = text/plain words = 1019 sentences = 57 flesch = 48 summary = A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure Eduardo Villarreal-Fernandez 1 , Ravi Patel 1 , Reshma Golamari 2 , Muhammad Khalid 2 , Ami DeWaters 2 and Philippe Haouzi 1* Indeed, since a profound hypoxemia appears to be the hallmark of COVID-19-associated pneumonia, the initial consensus [2] was to start invasive mechanical ventilation as soon as possible due to the overwhelming number of patients in respiratory failure presenting at the same time in a hospital and to prevent the risk of hypoxic cardiac arrest; (2) avoidance of high-flow nasal cannula (HFNC) to reduce respiratory droplet aerosolization for healthcare workers [3] in what was seen as "inevitable" intubations. After an initial increase in oxygen requirement through day 6, patients in this group were all able to be discharged at a time when most of the early-intubated patients were still mechanically ventilated (Fig. 1) . cache = ./cache/cord-252890-of29g89s.txt txt = ./txt/cord-252890-of29g89s.txt === reduce.pl bib === id = cord-252981-hywvmdjb author = Lockey, Stephen D. title = What’s Important: What Is Our Role in the COVID-19 Pandemic? date = 2020-04-10 pages = extension = .txt mime = text/plain words = 907 sentences = 45 flesch = 56 summary = The public health campaign encouraging social distancing must also provide tips for remaining safe from physical harm. The public must consider 2 important consequences of a trip to the emergency department in today's climate in addition to the harm created by the injury itself: (1) as the virus spreads, they are putting themselves at risk of exposure as providers triage and care for those with the disease; and (2) the time and resources it takes to care for injuries will create additional strain on our hospital system. With more than 25,000 orthopaedic surgeons in practice in the United States 1 caring for patients of all ages and demographics, there are specific steps we can take in order to help the public prevent hospital visits and take extra precautions to remain safe while social distancing. cache = ./cache/cord-252981-hywvmdjb.txt txt = ./txt/cord-252981-hywvmdjb.txt === reduce.pl bib === id = cord-253886-4b3i30hi author = Isakov, Alexander title = Transport and Management of Patients With Confirmed or Suspected Ebola Virus Disease date = 2015-05-21 pages = extension = .txt mime = text/plain words = 3694 sentences = 173 flesch = 41 summary = The foundation of safe care for patients with confirmed or suspected Ebola virus disease is effective infection control practice, which requires implementation of appropriate administrative policies, work practices, and environmental controls, accompanied by focused education, training, and supervision. However, the transport of the first patient with confirmed Ebola virus disease to the United States (Atlanta, GA), the transport of the first US-diagnosed Ebola virus disease case (Dallas, TX), and the first transmission of Ebola virus disease to health care workers in the United States understandably raised anxiety in the EMS community about the appropriate education and training, policies, and procedures, as well as supervision required, to be best prepared for transporting patients with serious communicable disease in the United States. The objectives of these hospital and out-of-hospital collaborations were to close education, training, and practice gaps to best facilitate the care for patients with serious communicable disease while ensuring the safety of the medics and the general public through meticulous implementation of infection control practices as recommended by CDC. cache = ./cache/cord-253886-4b3i30hi.txt txt = ./txt/cord-253886-4b3i30hi.txt === reduce.pl bib === id = cord-254269-x8vpnhd2 author = Hakim, Abraham A. title = Implications for the use of telehealth in surgical patients during the COVID-19 pandemic date = 2020-04-21 pages = extension = .txt mime = text/plain words = 1321 sentences = 81 flesch = 50 summary = A review of the PubMed Central and Medline provides articles examining the role of telemedicine for preoperative, postoperative, and follow up evaluation of surgical patients encompassing the past two decades. We report the summarized findings of these studies, the financial and HIPAA considerations of using telemedicine, potential benefits, pitfalls and strategies for the utilization of telemedicine into the clinical practice of general surgery and its subspecialties during the COVID-19 pandemic. While surgery may not seem like it would lend itself to telehealth practices, multiple studies have shown it can be a viable modality for safe and effective surgical care as an alternative to in-office visits in the pre and post-operative periods. The implementation of telehealth during the COVID-19 pandemic helps anyone and everyone adhere to policies of social distancing and reduce exposure, particularly patients at high risk Current use of telemedicine for post-discharge surgical care: a systematic review cache = ./cache/cord-254269-x8vpnhd2.txt txt = ./txt/cord-254269-x8vpnhd2.txt === reduce.pl bib === id = cord-253638-5f9ofdsc author = Alsaied, Tarek title = Coronavirus Disease 2019 (COVID‐19) Pandemic Implications in Pediatric and Adult Congenital Heart Disease date = 2020-06-10 pages = extension = .txt mime = text/plain words = 5683 sentences = 339 flesch = 49 summary = Given the increased risk for severe COVID‐19 observed in adults with underlying cardiac involvement, there is concern that patients with pediatric and congenital heart disease (CHD) may likewise be at increased risk for severe infection. In this review, we describe the effects of COVID‐19 in the pediatric and young adult population and review the cardiovascular involvement in COVID‐19 focusing on implications for patients with congenital heart disease in particular. 4-Cardiac care team members are at risk for acquiring COVID-19 and may play a role in spreading the disease between patients and in the society at large. It is important to know that 3.8% of the cases reported from China were of healthcare team members suggesting that health care providers are at a significantly increased risk of contracting COVID-19 11, 83 . cache = ./cache/cord-253638-5f9ofdsc.txt txt = ./txt/cord-253638-5f9ofdsc.txt === reduce.pl bib === === reduce.pl bib === id = cord-253417-ihi67m1u author = Paleri, Vinidh title = Rapid implementation of an evidence‐based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow‐up after treatment during the COVID‐19 pandemic: Model for international collaboration date = 2020-05-11 pages = extension = .txt mime = text/plain words = 3533 sentences = 186 flesch = 49 summary = title: Rapid implementation of an evidence‐based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow‐up after treatment during the COVID‐19 pandemic: Model for international collaboration The aim of this study is to demonstrate a rapid implementation of an evidence-based, structured, remote triaging system for assessment of suspected referrals and patients with cancer who are on regular follow-up after treatment for HNC in the United Kingdom (UK). Primary care practitioners' views (12 general practitioners in the North East were interviewed face to face between June 14, 2019 and December 5, 2019) discussing the head and neck cancer risk calculator (version 1) as a means to drive more confidence in the triage of patients to suspected cancer clinics was met with enthusiasm. Rapid implementation of an evidence-based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow cache = ./cache/cord-253417-ihi67m1u.txt txt = ./txt/cord-253417-ihi67m1u.txt === reduce.pl bib === id = cord-253129-v5lck9l7 author = Kim, Kyeong Tae title = Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial date = 2020-02-01 pages = extension = .txt mime = text/plain words = 8900 sentences = 540 flesch = 54 summary = BACKGROUND: Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. The Clinical utilisation of respiratory elastance (CURE) trial is a two-arm, randomised controlled trial (RCT) investigating the performance of PEEP selected at an objective, model-based minimal respiratory system elastance in patients with ARDS. Secondary outcomes include length of time of MV, ventilator-free days (VFD) up to 28 days, ICU and hospital length of stay, AUC of oxygen saturation (SpO(2))/FiO(2) during MV, number of desaturation events (SpO(2) < 88%), changes in respiratory mechanics and chest x-ray index scores, rescue therapies (prone positioning, nitric oxide use, extracorporeal membrane oxygenation) and hospital and 90-day mortality. Following the study, a phase-2 randomised controlled trial (RCT) was designed to assess mechanical ventilation at minimal elastance PEEP in patients with ARDS versus standard practice of care in a single-centre hospital. cache = ./cache/cord-253129-v5lck9l7.txt txt = ./txt/cord-253129-v5lck9l7.txt === reduce.pl bib === === reduce.pl bib === id = cord-253077-61fmul8c author = Vabret, Nicolas title = Immunology of COVID-19: current state of the science date = 2020-05-06 pages = extension = .txt mime = text/plain words = 20227 sentences = 1120 flesch = 45 summary = Lastly, Nonhuman primate (NHP) studies and patient data on SARS-CoV-1 have also shown that virus spike-specific IgG responses can exacerbate acute lung injury due to repolarization of alveolar macrophages into pro-inflammatory phenotypes and enhanced recruitment of inflammatory monocyte via CCL2 and IL-8 (Clay et al., 2012; Liu et al., 2019) . Collectively, these data suggest that cross-talk with monocytes might impair NK cell recognition and killing of SARS-CoV-2infected cells, and antibodies targeting IL-6 and TNF-signaling may benefit enhanced NK cell functions in COVID-19 patients ( Figure 2 ). However, these CD4 T cells lacked phenotypic markers of activation and were specific for C-terminal S protein epitopes that are highly similar to endemic human coronaviruses, suggesting that crossreactive CD4 memory T cells in some populations (e.g., children and younger patients that experience a higher incidence of hCoV infections) may be recruited into an amplified primary SARS-CoV-2-specific response (Braun et al., 2020) . cache = ./cache/cord-253077-61fmul8c.txt txt = ./txt/cord-253077-61fmul8c.txt === reduce.pl bib === === reduce.pl bib === id = cord-253189-uba6dy08 author = Walker, Katie title = The evidence base for scribes and the disruptions of COVID-19 date = 2020-09-21 pages = extension = .txt mime = text/plain words = 1700 sentences = 108 flesch = 57 summary = There has been a major expansion of scribe programs in the United States of America (USA) both in terms of their employment locations, now moving outside the emergency department (ED), and numbers, despite attempts to streamline documentation in electronic health records (EHRs) so that clerical support is no longer required. Many studies note that physicians go home soon after completion of their shift when working with a scribe but can't report the magnitude of the impact. Impact of COVID19 on scribe programs 2020 has provided significant challenges for EM and for all other medical settings as well. In summary, there is now some limited economic evidence for using scribes, with small improvements seen in physician productivity and increased per-patient revenue in the USA, but not patient flow. Impact of scribes on emergency medicine doctors' productivity and patient throughput: multicentre randomised trial An economic evaluation of the costs of training a medical scribe to work in Emergency Medicine cache = ./cache/cord-253189-uba6dy08.txt txt = ./txt/cord-253189-uba6dy08.txt === reduce.pl bib === id = cord-253862-jl1zhg13 author = Khalaf, Khalil title = SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment date = 2020-10-06 pages = extension = .txt mime = text/plain words = 14595 sentences = 760 flesch = 45 summary = Although this novel virus is less severe than the first SARS-CoV outbreak, human-to-human transmission remains very high and the number of cases continues to rise exponentially in major urban areas, highlighting the urgent need to develop new containment, diagnostic, and treatment protocols. In the case of SARS-CoV-2, viral evasion of the innate immune system leads to an increase in cytokine production and late CD4+/CD8+ response, which then leads to pathogenic inflammation in patients with high viral loads. (ChiCTR2000029308), involving severe SARS-CoV-2 cases, compared lopinavir/ritonavir treatment with standard care alone, and they showed that the antivirals yielded no clinical benefits. In an open-label control study conducted by Cai et al., the antiviral activity of favipiravir + IFN-α was compared to that of lopinavir/ritonavir + IFN-α in patients with confirmed SARS-CoV-2 infection. cache = ./cache/cord-253862-jl1zhg13.txt txt = ./txt/cord-253862-jl1zhg13.txt === reduce.pl bib === id = cord-253962-ug7yflxh author = Huang, Dong title = A novel risk score to predict diagnosis with Coronavirus Disease 2019 (COVID‐19) in suspected patients: A retrospective, multi‐center, observational study date = 2020-06-08 pages = extension = .txt mime = text/plain words = 2459 sentences = 198 flesch = 57 summary = title: A novel risk score to predict diagnosis with Coronavirus Disease 2019 (COVID‐19) in suspected patients: A retrospective, multi‐center, observational study BACKGROUND: The aim of the study was to explore a novel risk score to predict diagnosis with COVID‐19 among all suspected patients at admission. We found nine independent risk factors for diagnosis with COVID‐19 at admission to hospital: epidemiological exposure histories (OR:13.32, 95%CI 6.39‐27.75), weakness/fatigue (OR:4.51, 95%CI 1.70‐11.96), heart rate <100 beat/min (OR:3.80, 95%CI 2.00‐7.22), bilateral pneumonia (OR:3.60, 95%CI 1.83‐7.10), neutrophil count ≤6.3×10(9)/L (OR: 6.77, 95%CI 2.52‐18.19), eosinophil count ≤0.02×10(9)/L (OR:3.14, 95%CI 1.58‐6.22), glucose ≥6 mmol/L (OR:2.43, 95%CI 1.04‐5.66), D‐dimer ≥0.5 mg/L (OR:3.49, 95%CI 1.22‐9.96), and C‐reactive protein <5 mg/L (OR:3.83, 95%CI 1.86‐7.92). The current study is conducted aiming to explore the potential early risk factors, and to develop a risk score used for predicting the probability of diagnosis among all suspected COVID-19 patients at early stage. cache = ./cache/cord-253962-ug7yflxh.txt txt = ./txt/cord-253962-ug7yflxh.txt === reduce.pl bib === id = cord-252775-faxiem2w author = Tamagnini, Gabriele title = Cardiac surgery in the time of the novel coronavirus: Why we should think to a new normal date = 2020-07-15 pages = extension = .txt mime = text/plain words = 1722 sentences = 87 flesch = 45 summary = The Cardiac Surgery Departments have to think to a new normal: since the virus will remain endemic in the society, dedicated pathways or even dedicated Teams are pivotal to treat safely the patients, in respect of the safety of the health care workers. Moreover, we need a keen eye on deciding which pathologies have to be treated with priority: Coronary artery Disease showed a higher mortality rate in patients affected by COVID19, but it is, however, reasonable to think that all the cardiac pathologies affecting the lung circulation—such as symptomatic severe mitral diseases or aortic stenosis—might deserve a priority access to treatment, to increase the survival rate in case of an acquired‐Coronavirus infection later on. In epidemiological terms, it would be reasonable to consider a comparison of the age-profile overlap among patients who suffered from more severe COVID-19 with patients who undergo cardiac surgical procedures, since both prevalence of valvular diseases and casefatality rates for COVID-19 increase in the elderly patients. cache = ./cache/cord-252775-faxiem2w.txt txt = ./txt/cord-252775-faxiem2w.txt === reduce.pl bib === id = cord-253704-y0t30xw3 author = Lahiri, Durjoy title = COVID-19 Pandemic: A Neurological Perspective date = 2020-04-29 pages = extension = .txt mime = text/plain words = 4348 sentences = 210 flesch = 40 summary = Even though severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed to principally affect the respiratory system, neurological involvements have already been reported in some published work. Neurological manifestations can further be subdivided into the central nervous system (headache, dizziness, alteration of the sensorium, ataxia encephalitis, stroke, and seizures) and peripheral nervous system (skeletal muscle injury and peripheral nerve involvement including hyposmia and hypogeusia) symptomatology. Even though severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed to mainly affect the respiratory system, neurological involvements have already been reported in some published work. In the present paper, we have reviewed the recently published or pre-print original articles, case reports, and existing open-source data-sets in order to delineate the spectrum of neurological disorders in SARS-CoV-2 positive cases. Another report from China describes a case of acute myelitis, possibly affecting the cervical spinal cord, as evidenced by the clinical features, in a known patient of SARS-CoV-2 infection [22] . cache = ./cache/cord-253704-y0t30xw3.txt txt = ./txt/cord-253704-y0t30xw3.txt === reduce.pl bib === id = cord-253295-82ydczid author = Funkhouser, William K. title = Pathology: the clinical description of human disease date = 2020-07-24 pages = extension = .txt mime = text/plain words = 8864 sentences = 396 flesch = 34 summary = Patient workup uses present illness history with reference to past medical history, review of other organ systems for other abnormalities, review of family history, physical examination, radiographic studies, clinical laboratory studies (for example, peripheral blood or CSF specimens), and anatomic pathology laboratory studies (for example, tissue biopsy or pleural fluid cytology specimens). Obviously, arrival at the correct diagnosis is a function of the examining physician and pathologist (fund of knowledge, experience, alertness), the prevalence of the disease in question in the particular patient (age, race, sex, site), and the sensitivity/ specificity of the screening tests used (physical exam, vital signs, blood solutes, tissue stains, genetic assays). However, understanding the molecular and cellular pathogenesis of a disease allows development of screening methods to determine risk for clinically unaffected individuals, as well as mechanistic approaches to specific therapy. cache = ./cache/cord-253295-82ydczid.txt txt = ./txt/cord-253295-82ydczid.txt === reduce.pl bib === id = cord-254446-yxqbe1dj author = Ren, Yunzhao R. title = A Comprehensive Updated Review on SARS‐CoV‐2 and COVID‐19 date = 2020-05-29 pages = extension = .txt mime = text/plain words = 6723 sentences = 426 flesch = 49 summary = The disease name -COVID-19‖ and the associated virus name -SARS-CoV-2‖ were coined by the World Health Organization (WHO) and the Coronavirus Study Group of the International Committee on Virus Taxonomy, respectively, on February 11 1, 2 . Interestingly, pharyngeal swab viral nucleic acid screening results of 2,510 patients between January 23 and February 25 from a hospital fever clinic in Hunan Province (a neighboring province of Hubei) demonstrated that the positive rate of SARS-CoV-2 (1.3%) was lower than that of Influenza A (2.3%) and Influenza B (3.3%) 42 . Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial cache = ./cache/cord-254446-yxqbe1dj.txt txt = ./txt/cord-254446-yxqbe1dj.txt === reduce.pl bib === id = cord-253402-6sgeraws author = Remuzzi, Andrea title = COVID-19 and Italy: what next? date = 2020-03-13 pages = extension = .txt mime = text/plain words = 2847 sentences = 119 flesch = 55 summary = There is now grave concern regarding the Italian national health system's capacity to effectively respond to the needs of patients who are infected and require intensive care for SARS-CoV-2 pneumonia. At present, our national health system's capacity to effectively respond to the needs of those who are already infected and require admission to an intensive care unit for ARDS, largely due to SARS-CoV-2 pneumonia, is a matter of grave concern. Given that the mortality of patients who are critically ill with SARS-CoV-2 pneumonia is high and that the survival time of non-survivors is 1-2 weeks, the number of people infected in Italy will probably impose a major strain on critical care facilities in our hospitals, some of which do not have adequate resources or staff to deal with this emergency. We predict that if the exponential trend continues for the next few days, more than 2500 hospital beds for patients in intensive care units will be needed in only 1 week to treat ARDS caused by SARS-CoV-2-pneumonia in Italy. cache = ./cache/cord-253402-6sgeraws.txt txt = ./txt/cord-253402-6sgeraws.txt === reduce.pl bib === id = cord-253746-15w4gquq author = Goldman, Michel title = Reflections on the Collaborative Fight Against COVID-19 date = 2020-09-17 pages = extension = .txt mime = text/plain words = 1633 sentences = 75 flesch = 41 summary = As therapeutic interventions in the early phase of the disease are attracting more and more interest, we argue that now is the time to involve patients' organizations in the design of clinical protocols in order to define the most relevant end-points and assess the risk-benefit balance of new therapies. In this editorial perspective, we argue that patients' voice will be essential to ensure uptake in the wider public of new therapies and vaccines resulting from these initiatives. Therefore, it is essential that trials are designed to include sufficient numbers of patients within the period of time during which the pandemic is expected to be active. Furthermore, patient reported outcomes are essential to assess the impact of therapeutic interventions on the long-term consequences of COVID-19 (13) . It is therefore important that patient organizations are involved early on in the design of clinical trials. cache = ./cache/cord-253746-15w4gquq.txt txt = ./txt/cord-253746-15w4gquq.txt === reduce.pl bib === id = cord-253970-sbj869yy author = Agarwal, Amit title = Neurological emergencies associated with COVID-19: stroke and beyond date = 2020-08-11 pages = extension = .txt mime = text/plain words = 2417 sentences = 149 flesch = 40 summary = There is limited knowledge on the neurologic manifestations of COVID-19 at present, with a wide array of neurological complications reported, ranging from ischemic stroke to acute demyelination and encephalitis. The second subset of neurological presentation involves a response to the cytokine storm and multi-system inflammation including acute demyelination, vasculitis, necrotizing encephalopathy, and posterior reversible encephalopathy syndrome. Table 1 provides a summary of the most common (1) vascular complications with stroke secondary to arterial or venous thrombosis, related to the known hypercoagulable state seen in COVID [4, 5, 14] , and (2) much broader gamut including diffuse leukoencephalopathy, acute demyelination, posterior reversible encephalopathy syndrome (PRES), necrotizing encephalopathy, and focal cytotoxic edema, primarily seen as a consequence of systemic inflammation and cytokine storm seen with COVID-19 [6] [7] [8] [9] [10] [11] [12] [13] . The most common neurological presentation reported has been ischemic stroke, secondary to arterial or venous thrombosis, because of the hypercoagulable state associated with COVID-19. cache = ./cache/cord-253970-sbj869yy.txt txt = ./txt/cord-253970-sbj869yy.txt === reduce.pl bib === id = cord-254428-n0uwy77g author = Zhao, Wen title = Clinical characteristics and durations of hospitalized patients with COVID-19 in Beijing: a retrospective cohort study date = 2020-03-17 pages = extension = .txt mime = text/plain words = 3390 sentences = 202 flesch = 53 summary = Multivariable stepwise Cox regression model showed bilateral pneumonia on CT scan, shorter time from the illness onset to admission, the severity of disease and lymphopenia were independently associated with longer hospitalized duration. In the present study, we reported the retrospective data of 77 hospitalized patient with COVID-19 in Beijing, China, with 64 (83.1%) discharged home alive by the end of follow-up. Previous studies reported that the duration of the illness onset to hospital admission in the early stage of this outbreak was 7 to 12.5 days. Currently, few studies reported the average hospital length of stay of discharged patients COVID-19. Bilateral pneumonia on CT scan, shorter period of illness onset to admission, lymphopenia, severity of disease are the risk factors for longer hospitalization duration of COVID-19. Bilateral pneumonia on CT scan, shorter period of illness onset to admission, lymphopenia, severity of disease are the risk factors for longer hospitalization duration of COVID-19. cache = ./cache/cord-254428-n0uwy77g.txt txt = ./txt/cord-254428-n0uwy77g.txt === reduce.pl bib === id = cord-254478-scc9wee0 author = To, Kelvin Kai-Wang title = Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study date = 2020-03-23 pages = extension = .txt mime = text/plain words = 5189 sentences = 294 flesch = 53 summary = title: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study Comprehensive data for serial respiratory viral load and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not yet available. Nasopharyngeal and throat swabs are usually obtained for serial viral load monitoring of respiratory infections but gathering these specimens can cause discomfort for patients and put health-care workers at risk. We aimed to ascertain the serial respiratory viral load of SARS-CoV-2 in posterior oropharyngeal (deep throat) saliva samples from patients with COVID-19, and serum antibody responses. We present findings of an observational cohort study of the temporal profile of viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from posterior oropharyngeal saliva samples and serum antibody responses, dated by symptom onset and correlated with clinical findings. cache = ./cache/cord-254478-scc9wee0.txt txt = ./txt/cord-254478-scc9wee0.txt === reduce.pl bib === id = cord-254040-s3k51rkk author = Bombaci, Alessandro title = Telemedicine for management of patients with amyotrophic lateral sclerosis through COVID-19 tail date = 2020-10-06 pages = extension = .txt mime = text/plain words = 2142 sentences = 104 flesch = 37 summary = In this context, patients affected by chronic neurological diseases, such as amyotrophic lateral sclerosis (ALS), are at risk to be lost at follow-up, leading to a higher risk of morbidity and mortality. In this context, patients affected by chronic neurological diseases, such as amyotrophic lateral sclerosis (ALS), are at risk of being lost at follow-up with a consequently higher morbidity and mortality. Neurological examination and ALS Functional Rating Scale revised (ALSFRSr) are the most important tools to monitor disease progression. In a recent randomized trial comparing remote nutritional counseling with or without mobile health technology in ALS patients, Nu Planit application was an acceptable and useful mobile app to check nutritional status [17] . In conclusion, implementing telemedicine services for patients with ALS is necessary to allow direct clinical evaluation during COVID-19 pandemic, in order to plan the appropriate medical and nursing care, avoiding hospitalizations or urgent interventions. Telemedicine for patients with amyotrophic lateral sclerosis during COVID-19 pandemic: an Italian ALS referral center experience cache = ./cache/cord-254040-s3k51rkk.txt txt = ./txt/cord-254040-s3k51rkk.txt === reduce.pl bib === id = cord-253730-cdkzvfib author = Suzuki, Emily title = Assessment of the Need for Early Initiation of Rehabilitation Treatments in Patients with Coronavirus Disease 2019 date = 2020-08-13 pages = extension = .txt mime = text/plain words = 3452 sentences = 188 flesch = 45 summary = OBJECTIVE: The aim of this study was to describe the clinical characteristics of coronavirus disease (COVID-19) patients, including risk factors for deep vein thrombosis and pulmonary embolism, and to evaluate the need for rehabilitation to prevent pulmonary embolism. The clinical characteristics and blood test results of patients with no history on admission of oral anticoagulant use were evaluated to assess the importance of inflammation and clotting function as risk factors for pulmonary embolism. 8) Because hypercoagulability and hyperinflammation have been reported in patients with COVID-19, we compared coagulability and inflammation by sex and the severity of COVID-19 to identify risk factors for PE that can be used to determine the necessity of early rehabilitation intervention to prevent PE. Considering the high risk of hospital-acquired infections and the worldwide shortage of medical resources, including not only PPE but also physicians, nurses, and rehabilitation therapists, it is understandable that the guidelines for physiotherapy do not recommend affirmative intervention for patients with moderate to severe COVID-19. cache = ./cache/cord-253730-cdkzvfib.txt txt = ./txt/cord-253730-cdkzvfib.txt === reduce.pl bib === id = cord-254990-nrzwn6oz author = Mayer, Kirby P. title = Recovery from COVID-19 and acute respiratory distress syndrome: the potential role of an intensive care unit recovery clinic: a case report date = 2020-09-10 pages = extension = .txt mime = text/plain words = 3117 sentences = 169 flesch = 49 summary = The purpose of this case report is to highlight the potential role of intensive care unit recovery or follow-up clinics for patients surviving acute hospitalization for coronavirus disease 2019. CASE PRESENTATION: Our patient was a 27-year-old Caucasian woman with a past medical history of asthma transferred from a community hospital to our medical intensive care unit for acute hypoxic respiratory failure due to bilateral pneumonia requiring mechanical ventilation (ratio of arterial oxygen partial pressure to fraction of inspired oxygen, 180). CONCLUSION: We present this case report to suggest that patients surviving coronavirus disease 2019 with subsequent development of acute respiratory distress syndrome will require more intense intensive care unit recovery follow-up. The patient's family reported no travel history or exposure risk, but, given the Fig. 1 Chest radiograph obtained on day 1 of admission to intensive care unit revealed bibasilar airspace disease patient's clinical symptoms, a test for COVID-19 was performed. cache = ./cache/cord-254990-nrzwn6oz.txt txt = ./txt/cord-254990-nrzwn6oz.txt === reduce.pl bib === id = cord-005453-4057qib7 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date = 2019-07-03 pages = extension = .txt mime = text/plain words = 275771 sentences = 16876 flesch = 56 summary = To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. cache = ./cache/cord-005453-4057qib7.txt txt = ./txt/cord-005453-4057qib7.txt === reduce.pl bib === id = cord-255233-rvgj6pvk author = Munday, Molly-Rose title = A Pilot Study Examining Vitamin C Levels in Periodontal Patients date = 2020-07-28 pages = extension = .txt mime = text/plain words = 3895 sentences = 238 flesch = 51 summary = Methods: Patients were invited to participate following assessment and treatment at the Westmead Centre of Oral Health Periodontic Clinic, regardless of current disease stage or treatment. Conclusion: Although a small study, this rate of vitamin C deficiency in the periodontal clinic is clinically important and correlations with disease severity and CRP suggests biological importance. Vitamin C deficiency is more common in smokers, the elderly and people of lower socio-economic status, potentially putting those groups at increased risk of periodontal diseases [24, 25] . Patients were eligible to participate in this study if they were an adult attending the Westmead Centre of Oral Health (WCOH) Periodontic Clinic. Patients were eligible to participate in this study if they were an adult attending the Westmead Centre of Oral Health (WCOH) Periodontic Clinic. This study reports that a significant proportion of patients attending the Periodontics Clinic at the Westmead Centre of Oral Health have vitamin C deficiency. cache = ./cache/cord-255233-rvgj6pvk.txt txt = ./txt/cord-255233-rvgj6pvk.txt === reduce.pl bib === id = cord-255197-79yfslu1 author = Soo, Chun Ian title = Telehealth: “virtual” lifeline for home-ventilated patients during the COVID-19 pandemic date = 2020-09-28 pages = extension = .txt mime = text/plain words = 1155 sentences = 63 flesch = 38 summary = title: Telehealth: "virtual" lifeline for home-ventilated patients during the COVID-19 pandemic Telehealth appears useful to fill in the void for home-ventilated patients to maintain the much-needed connectivity with their healthcare team during the #COVID19 pandemic https://bit.ly/3ftvjxW The emergence of PAP devices also resulted in a higher number of patients requiring long-term medical care and ventilation. HMV support generally comprises a mobile healthcare team (HCT), which delivers services to the patient at their homes or long-term care facility. In contrast, telehealth is an umbrella term that encompasses telemedicine and the distribution of nonclinical services such as medical information and provider training [4] . Through information and communications technology, telehealth provides a network link to enable remote collaboration between the patient or their caregivers and HCTs, who are geographically separated. Technological advances in home non-invasive ventilation monitoring: reliability of data and effect on patient outcomes cache = ./cache/cord-255197-79yfslu1.txt txt = ./txt/cord-255197-79yfslu1.txt === reduce.pl bib === === reduce.pl bib === id = cord-254993-bndl93qr author = Sonnweber, Thomas title = Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study date = 2020-10-21 pages = extension = .txt mime = text/plain words = 3684 sentences = 192 flesch = 41 summary = To shed light on the regulation of iron metabolism and its impact on monocyte immune effector functions at the cellular level, we investigated the mRNA expression of key mediators of iron homeostasis as well as cytokine expression in PBMCs. In line with serum hepcidin measurements, we also found increased hepcidin mRNA (HAMP, for hepcidin antimicrobial peptide) expression in PBMCs isolated from subjects who previously had severe to critical COVID-19 as compared to those who suffered from milder disease (Fig. 2) . In contrast, the immune effector function of PBMCs was related to COVID-19 severity, as mononuclear cells obtained from patients, who suffered from severe to critical disease, demonstrated higher levels of interleukin 10 (IL10, p = 0.044) and tumour necrosis factor (TNF, p = 0.024) mRNA expression as compared to subjects with a milder course of COVID-19 (Fig. 2) . cache = ./cache/cord-254993-bndl93qr.txt txt = ./txt/cord-254993-bndl93qr.txt === reduce.pl bib === id = cord-254357-5s84kimn author = Morse, Alan R title = Decreasing Avoidable Vision Loss: Identifying Antecedents of Adherence date = 2020-11-02 pages = extension = .txt mime = text/plain words = 2937 sentences = 144 flesch = 34 summary = Adherence to medication treatment protocols and active participation by individuals in their medical care are important for all patients, but especially for those with chronic conditions such as vision loss. 13 Lack of patient-physician communication can impair treatment effectiveness and result in vision loss since as many as 30% of all prescriptions are never filled 14 and within 6 months, an estimated 50% of prescriptions that are filled are no longer being used; 15 whether cost is a factor in such cases is unknown. 23, 24 For patients with AMD or diabetic eye disease, failure keeps scheduled appointments for intravitreal injections or monitoring undermines treatment efficacy, impairs successful patient outcomes and results in loss of vision that might have been avoided. Active participation by individuals in their medical care is important for all patients, but especially for those with chronic conditions such as vision loss. cache = ./cache/cord-254357-5s84kimn.txt txt = ./txt/cord-254357-5s84kimn.txt === reduce.pl bib === id = cord-254852-qr5gdmbc author = Grief, Samuel N. title = Guidelines for the Evaluation and Treatment of Pneumonia date = 2018-08-14 pages = extension = .txt mime = text/plain words = 4731 sentences = 300 flesch = 39 summary = A 2015 prospective, multi-center study by the Centers for Disease Control and Prevention identified a responsible pathogen in only 38% of cases of community-acquired pneumonia (CAP) in adults requiring hospitalization. 13 However, more extensive diagnostic testing should be considered in patients who are at risk for infection with unusual pathogens, who are not responding to treatment, or when additional testing is likely to change antibiotic management (Table 3) . Their analysis of 13 randomized controlled trials found significantly decreased mortality in severe pneumonia, decreased need for mechanical ventilation, decreased occurrence of acute respiratory distress syndrome, decreased time to clinical stability, and shorter duration of hospitalization. Elderly patients with pneumonia may not exhibit typical symptoms or physical examination findings seen in younger adults, such as pleuritic chest pain, cough, fever, and leukocytosis. Impact of inappropriate antibiotic therapy on mortality in patients with ventilator-associate pneumonia and blood stream infection: a meta-analysis cache = ./cache/cord-254852-qr5gdmbc.txt txt = ./txt/cord-254852-qr5gdmbc.txt === reduce.pl bib === === reduce.pl bib === id = cord-255300-btyth32l author = Kang, Swan title = Oculoplastic video-based telemedicine consultations: Covid-19 and beyond date = 2020-05-12 pages = extension = .txt mime = text/plain words = 1176 sentences = 65 flesch = 44 summary = Telemedicine offers distinct benefits to patients, clinicians, and communities during the current crisis: it supports social distancing measures by minimising the need for patients and clinicians to travel to hospitals; it enables continued service delivery at a time when in-person outpatient activity has been severely restricted, supporting patients continued access to medical care, promoting patient confidence and reducing patient and clinician anxiety; and reducing the anticipated surge in demand when normal services resume by allowing existing referral, surgery booking, follow-up and discharge pathways to continue. In response to the Covid-19 pandemic, our institution has rapidly deployed video consultations using Attend Anywhere, a browser-based platform that allows clinicians to work through a list of patients in a virtual waiting room. When greater resolution imaging was required, for example of an eyelid lesion, patients were usually able to take a good-quality photograph themselves using a smartphone camera, and digitally transfer this to the evaluating clinician to review, during the video consultation. cache = ./cache/cord-255300-btyth32l.txt txt = ./txt/cord-255300-btyth32l.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-254382-xy8se56o author = Santos, C. title = Comparative Incidence and Outcomes of COVID-19 in Kidney or Kidney-Pancreas Transplant Recipients Versus Kidney or Kidney-Pancreas Waitlisted Patients: A Pilot Study date = 2020-07-25 pages = extension = .txt mime = text/plain words = 3660 sentences = 243 flesch = 42 summary = In this retrospective cohort pilot study, we determined the incidence and outcomes of COVID-19 in kidney or kidney-pancreas transplant recipients and kidney or kidney-pancreas waitlisted patients in our center. We hypothesize that these patients have an incidence proportion of COVID-19 similar to the general population, but that transplanted patients have greater occurrences of hospitalization, intensive care unit admission, mechanical ventilation and death compared to waitlisted patients due to chronic immunosuppression. Demographic data, vital signs (temperature and body mass index), laboratory results, hospitalization, intensive care unit admission, mechanical ventilation, and death were captured from the electronic datasets, whereas comorbidities, organ type, cause of renal disease, induction and maintenance immunosuppression, presenting symptoms for COVID-19, oxygen supplementation, chest radiographic findings, and treatments tried for COVID-19 were collected by manual chart review. . https://doi.org/10.1101/2020.07.20.20157990 doi: medRxiv preprint Previous epidemiologic studies on COVID-19 in kidney transplant recipients focused on assembling cohorts of patients diagnosed with COVID-19 and describing their clinical features and outcomes. cache = ./cache/cord-254382-xy8se56o.txt txt = ./txt/cord-254382-xy8se56o.txt === reduce.pl bib === === reduce.pl bib === id = cord-254377-j8e8gb0l author = Ali, Sadaf title = Acute cor pulmonale from saddle pulmonary embolism in a patient with previous Covid-19 – should we prolong prophylactic anticoagulation? date = 2020-06-13 pages = extension = .txt mime = text/plain words = 1447 sentences = 87 flesch = 43 summary = However, the risk associated with mild and moderate illness from Covid-19 is unknown, and there is no current recommendation for prophylaxis against thromboembolism in patients after hospital treatment unless there are established thrombophilic risk factors. We report the case of a 52-year old woman, who presented with massive saddle pulmonary embolism after one week of initial hospital discharge, successfully thrombolysed that raises the question of consideration of extended prophylactic anticoagulation even in low risk Covid-19 cases. 3 We report a case of acute massive PE successfully managed by thrombolysis in a patient who was discharged after one week of initial hospital treatment for Covid-19 pneumonia which raises serious concerns about the indication for extended prophylactic anticoagulation in such cases. Emerging data and clinical experience suggest an increased prevalence of venous thromboembolic events (VTE) in COVID-19, especially in patients with severe disease requiring hospitalization, and even among those who are not critically ill. cache = ./cache/cord-254377-j8e8gb0l.txt txt = ./txt/cord-254377-j8e8gb0l.txt === reduce.pl bib === id = cord-254777-h8hw4m9f author = Tanner, Tamara title = Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19 date = 2020-07-29 pages = extension = .txt mime = text/plain words = 4731 sentences = 248 flesch = 42 summary = Cytokine storm syndromes include various entities, depending on the inciting factor: primary Hemophagocytic Lymphohistiocytosis [HLH] in children with specific genetic mutations; secondary HLH due to infection or malignancy, macrophage activation syndrome due to rheumatologic disease and cytokine release syndrome (CRS) when hyperinflammation is due to CAR T-cell therapy. Although still under investigation, ADE has been proposed as a potential mechanism underlying the newly described MIS-C, based on the observation that a majority of the patients have evidence of existing antibodies to SARS-CoV-2 and the inflammatory condition seems to lag behind the COVID-19 infection peak by approximately 4-6 weeks. The rationale for use of IL-6 blockade in serious COVID-19 infections is based on the observation that for the subset of patients with severe manifestations, IL-6 is most likely one of the drivers of the cytokine storm, and elevated levels of IL-6 have been consistently shown [14] . cache = ./cache/cord-254777-h8hw4m9f.txt txt = ./txt/cord-254777-h8hw4m9f.txt === reduce.pl bib === === reduce.pl bib === id = cord-254595-by2j7byz author = Rao, Sandesh S. title = Establishing Telemedicine in an Academic Total Joint Arthroplasty Practice: Needs and Opportunities Highlighted by the COVID-19 Pandemic date = 2020-04-23 pages = extension = .txt mime = text/plain words = 957 sentences = 57 flesch = 48 summary = To help control spread of this pandemic, many centers have boosted telemedicine capability to care for patients who would typically be seen in person in outpatient settings, including total joint arthroplasty clinics. We review key components relevant to the establishment and effective use of telemedicine, focused on patient education, practice logistics, technological considerations, and sensitive patient health information–associated compliance factors, which are necessary to provide care remotely for total joint arthroplasty patients. Orthopaedic surgeons who primarily perform total joint arthroplasty (TJA) of the hip and 41 knee treat a predominantly outpatient population that is at high risk for complications and death 42 from 44, 54] Most patients of adult reconstruction clinics are older than 60 years, 43 and many have comorbidities that put them at high risk of contracting severe acute respiratory 44 syndrome coronavirus 2 (SARS-CoV-2) if exposed. [65] Therefore, an effective and efficient 45 TJA telemedicine practice may enable providers to continue delivering care while preventing 46 unnecessary exposure of at-risk patients to the outpatient clinic during this pandemic. cache = ./cache/cord-254595-by2j7byz.txt txt = ./txt/cord-254595-by2j7byz.txt === reduce.pl bib === id = cord-023211-kt5gt26t author = nan title = Poster Session Abstracts date = 2007-08-29 pages = extension = .txt mime = text/plain words = 221224 sentences = 11772 flesch = 52 summary = Previous studies performed using fluorescence halide efflux measurements and short-circuit current voltage clamp have shown that treatment with PPARγ (peroxisome proliferator activated receptor gamma) agonists, such as pioglitazone and FLL (FMOC-L-leucine), resulted in an increased biosynthesis and trafficking of ∆F508-CFTR to the cell surface. Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom Recent progress in the development of small molecule correctors and potentiators capable of restoring CFTR function have increased the need for pre-clinical test models including cultured airway epithelial cells from human CF patients as well as CF mouse models. Clinical studies have linked increased sputum and peripheral blood neutrophil MPO activity with increased airflow obstruction in cystic fibrosis (CF) patients of the same age, gender, airway bacterial flora, and CFTR genotype. Because patients expressing low levels of normal CFTR mRNA (5-20%) have mild disease symptoms, these studies demonstrate that the incorporation of the ciliated cell-specific FOXJ1 promoter into gene therapy vectors may be useful for treatment of CF. cache = ./cache/cord-023211-kt5gt26t.txt txt = ./txt/cord-023211-kt5gt26t.txt === reduce.pl bib === id = cord-255519-tcobane8 author = Bartels, Matthew N. title = Acute Medical Conditions: Cardiopulmonary Disease, Medical Frailty, and Renal Failure date = 2020-10-02 pages = extension = .txt mime = text/plain words = 19990 sentences = 1027 flesch = 33 summary = The population of patients who benefit from both cardiac and pulmonary rehabilitation is increasing as the population ages and heart disease remains a leading cause of global morbidity and mortality. Many patients with stroke, vascular disease, or other conditions can be included in active cardiac and pulmonary rehabilitation programs or benefit from the application of cardiopulmonary rehabilitation principles to their rehabilitation. For secondary prevention in patients with known cardiopulmonary disease, exercise should be at a safe level at 60% or more of the maximum heart rate to achieve a training effect. 82 Rehabilitation is focused on a program that resembles exercise for patients with heart failure, with the addition of close monitoring of oxygen saturation and the use of appropriate levels of supplemental oxygen to prevent hypoxemia. Individuals who are disabled tend to have lower activity levels, which puts them at increased risk of cardiac and pulmonary disease and may present obstacles for a standard rehabilitation program for a person who is newly disabled and who has preexisting cardiopulmonary limitations. cache = ./cache/cord-255519-tcobane8.txt txt = ./txt/cord-255519-tcobane8.txt === reduce.pl bib === id = cord-256109-dkp0fwe3 author = Mazzulli, Tony title = Severe Acute Respiratory Syndrome–associated Coronavirus in Lung Tissue date = 2004-01-17 pages = extension = .txt mime = text/plain words = 2554 sentences = 115 flesch = 53 summary = Efforts to contain severe acute respiratory syndrome (SARS) have been limited by the lack of a standardized, sensitive, and specific test for SARS-associated coronavirus (CoV). Efforts to contain severe acute respiratory syndrome (SARS) have been limited by the lack of a standardized, sensitive, and specific test for SARS-associated coronavirus (CoV). All patients who met the current World Health Organization case definition of probable SARS and who underwent a postmortem examination in Canada during the March-April 2003 outbreak were included in this study. The clinical description and RT-PCR results for the 11 patients with probable SARS from whom postmortem lung tissue samples were examined are summarized in Table 1 . By using a standardized RT-PCR assay, SARS-CoV has been unequivocally identified in the lung tissue of all patients who died with probable SARS but not in any of the controls. cache = ./cache/cord-256109-dkp0fwe3.txt txt = ./txt/cord-256109-dkp0fwe3.txt === reduce.pl bib === id = cord-255831-nrc35tug author = Alviggi, Carlo title = COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management date = 2020-05-13 pages = extension = .txt mime = text/plain words = 4469 sentences = 243 flesch = 45 summary = The prolonged lockdown of health services providing high-complexity fertility treatments –as currently recommended by many reproductive medicine entities– is detrimental for society as a whole, and infertility patients in particular. Along these lines, the ART calculator -a clinical predictive model used to estimate the number of mature (metaphase II) oocytes needed to obtain at least one euploid embryo in couples undergoing ARTindicates that 13 (95% confidence interval [CI]: 11-16), 16 (95% CI: [13] [14] [15] [16] [17] [18] [19] [20] , and 19 (95% CI: [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] oocytes are needed for women aged 38, 39, and 40 years, respectively [10, 11] . Based on female age, ovarian reserve, and previous history of ovarian stimulation -if available-, 'low prognosis' patients were stratified into four specific subgroups, each of which with a distinct prognosis concerning the likelihood of conceiving and delivering a baby with the use of ART (Supplementary Figure 3) . cache = ./cache/cord-255831-nrc35tug.txt txt = ./txt/cord-255831-nrc35tug.txt === reduce.pl bib === id = cord-256011-0cr4ejxu author = de Castro-Hamoy, Leniza title = Age Matters but it should not be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID-19 date = 2020-06-16 pages = extension = .txt mime = text/plain words = 4410 sentences = 185 flesch = 51 summary = This paper examines the fairness of recommendations contained in resource allocation guidelines in the Philippines that have implications for the way elderly patients could be treated or excluded from some forms of critical care treatment in the context of the ongoing Corona virus emergency. Anticipating a surge in demand for ventilators and other critical care equipment at the height of the COVID-19 pandemic, many institutions, agencies, and responsible authorities have had to issue guidelines or recommendations for the allocation of scarce medical resources in their respective territories or jurisdictions. After starting with an examination of the principle of net utility, the commentary goes on to explore and clarify what the TFG means by "maximizing prognosis." It emphasizes the importance of invoking short-term-rather than long-term-prognosis as a criterion to determine a patient's ability to benefit from the use of critical care resources during the period of scarcity. cache = ./cache/cord-256011-0cr4ejxu.txt txt = ./txt/cord-256011-0cr4ejxu.txt === reduce.pl bib === id = cord-256262-lwc4ghj2 author = Gangneux, Jean-Pierre title = Invasive fungal diseases during COVID-19: We should be prepared date = 2020-04-06 pages = extension = .txt mime = text/plain words = 1141 sentences = 60 flesch = 36 summary = Among various causes of morbidity and mortality in COVID-19 patients, the frequency and impact of co-infections has still been poorly studied, particularly in patients with an acute respiratory distress syndrome (ARDS). In France, IFI account for a high risk of mortality in patients with co-morbidities from 9.2% to 40% depending on the fungal disease (8) . Invasive mucormycosis is increasingly reported (thanks to the improvement of diagnostic tools) in susceptible patients such as those suffering from diabetes, hematological malignancies, solid organ transplantation or chronic respiratory diseases and superficial injuries in burned patients or after local traumatism. In case of positivity of any of these tests, a confirmation step with blood biomarkers will be implemented depending on the positive results, with serum galactomannan and/or serum beta-D-glucan and/or cryptococcal antigenemia and/or blood qPCR for Aspergillus or mucorales, -national multicentric studies that aim to explore the risk of fungal co-infection during COVID-19 with joint consortia of ICU and Mycology specialists. cache = ./cache/cord-256262-lwc4ghj2.txt txt = ./txt/cord-256262-lwc4ghj2.txt === reduce.pl bib === id = cord-256051-87alqfkd author = Revzin, Margarita V. title = Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications date = 2020-10-01 pages = extension = .txt mime = text/plain words = 8850 sentences = 448 flesch = 39 summary = Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in coronavirus disease 2019 (COVID-19), which was declared an official pandemic by the World Health Organization on March 11, 2020. Although SARS-CoV-2 disease (or coronavirus disease 2019 ) primarily manifests as a lung infection, with symptoms ranging from those of a mild upper respiratory infection to severe pneumonia and acute respiratory distress syndrome (ARDS), other multisystemic manifestations of this disease and related complications are becoming more commonly recognized (3) . Thromboembolic complications, including pulmonary embolism (PE), peripheral venous and arterial thrombosis, and acute stroke (seen also in patients older than 50 years without risk factors) have all been reported (50-57). On the basis of the pattern and distribution of the opacities and the presence or absence of certain clinical signs (such as obesity), the authors developed a chest radiography severity scoring system that could be used as a prognostic factor of outcomes in young adult patients with COVID-19 (Fig 3) . cache = ./cache/cord-256051-87alqfkd.txt txt = ./txt/cord-256051-87alqfkd.txt === reduce.pl bib === id = cord-254494-wbfgrez1 author = Shi, Chunhong title = Barriers to Self-Management of Type 2 Diabetes During COVID-19 Medical Isolation: A Qualitative Study date = 2020-10-14 pages = extension = .txt mime = text/plain words = 5751 sentences = 338 flesch = 45 summary = RESULTS: Barriers to diabetes self-management identified by patients with diabetes during isolation were categorized into five major themes: inadequate knowledge and behavioral beliefs, shortage of resources, suffering from health problems, negative emotions, and lack of support. Studies in developed countries such as the United States, Canada, the United Kingdom, and Singapore have found that common barriers to self-management include poor communication between patients and healthcare providers, limited accessibility to healthcare facilities, lack of family support, inadequate disease knowledge and limited disease treatment methods, lack of motivation for change, physical and cognitive disorders, limited access to diabetes education, and financial barriers. This study addressed a gap in this field by interviewing patients with diabetes subjected to medical isolation after recovering from COVID-19 to gain a deeper understanding of the barriers to diabetes self-management, and provide new perspectives and approaches for the design of interventions and formulation of policies. cache = ./cache/cord-254494-wbfgrez1.txt txt = ./txt/cord-254494-wbfgrez1.txt === reduce.pl bib === id = cord-255037-i9guxtix author = Reda, Gianluigi title = Reply to “CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report” Analysis of six hematological centers in Lombardy: On behalf of CLL commission of Lombardy Hematology Network (REL) date = 2020-08-04 pages = extension = .txt mime = text/plain words = 1177 sentences = 62 flesch = 40 summary = The authors also refer to the recent recommendations for the management of cancer patients in COVID era published by the EHA Infectious Disease Scientific Working Group Executive Committee. On the one hand, CLL is associated with a disease-related disruption of both humoral and cell-mediated immunity, on the other hand, patient-related factors such as age, disease stage, and type of treatment received play an important role [6] . Ibrutinib, an irreversible inhibitor of Bruton's tyrosine kinase (Btk) currently represents a milestone in the treatment of CLL and has been approved by FDA for the treatment of several B-cell malignancies and chronic graft-versus-host disease (cGVHD). Among 2902 CLL patients, 23 cases of COVID infections have been reported with molecular testing for SARS-CoV-2. In addition to its role on Btk, ibrutinib shows off-target inhibiting activity on IL-2-inducible T-cell kinase (Itk) and is thus capable of rebalancing the disease-inherent Th1/Th2 unbalance toward a Th1 phenotype in CLL patients. CLL and COVID-19 at the hospital clinic of Barcelona: an interim report cache = ./cache/cord-255037-i9guxtix.txt txt = ./txt/cord-255037-i9guxtix.txt === reduce.pl bib === id = cord-255435-mr239gai author = Sher, Yelizaveta title = A CASE REPORT OF COVID-19 ASSOCIATED HYPERACTIVE ICU DELIRIUM WITH PROPOSED PATHOPHYSIOLOGY AND TREATMENT date = 2020-05-19 pages = extension = .txt mime = text/plain words = 3528 sentences = 182 flesch = 35 summary = Delirium, which is highly prevalent in general intensive care unit (ICU) populations, is expected to be frequent and prominent in COVID-19 patients hospitalized with acute respiratory distress syndrome (ARDS) in ICU. Delirium, which is highly prevalent in general intensive care unit (ICU) populations, is expected to be frequent and prominent in COVID-19 patients hospitalized with acute respiratory distress syndrome (ARDS) in ICU. In addition to case presentation, we discuss a proposed delirium pathophysiology in COVID-19 associated delirium and a systematized approach to evaluation and management of such patients. Intravenous valproic acid (VPA; titrated to 1250 mg per day) was also started for management of agitation and symptoms of hyperactive delirium and to facilitate tapering of multiple other sedative deliriogenic medications. At our center, the following medications have been used in management of agitation in patients with COVID-19 ICU-associated hyperactive delirium, including the described patient, with following considerations. cache = ./cache/cord-255435-mr239gai.txt txt = ./txt/cord-255435-mr239gai.txt === reduce.pl bib === === reduce.pl bib === id = cord-255460-r5p5helx author = Aggarwal, Sadhna title = Drug repurposing for breast cancer therapy: Old weapon for new battle date = 2019-09-21 pages = extension = .txt mime = text/plain words = 7318 sentences = 420 flesch = 42 summary = A phase III clinical trial 'Breast Cancer Trial of Oral Everolimus-2 (BOLERO-2)' that included everolimus in combination with exemestane was successfully completed in 2012 leading to the approval of everolimus by US FDA for the treatment of HR + , HER2 − advanced metastatic cancers that are resistant to letrozole or anastrazole [125, 126] . Docetaxel and paclitaxel are used as neoadjuvant or adjuvant therapy as single agent or in combination with other chemotherapeutic agents for the treatment of early, advanced and metastatic breast cancer in pre-and postmenopausal women. We thus conclude that comprehensive approach of selecting the most appropriate gene-protein-pathway-target-drug modeling via integration of system biology and bioinformatics holds the high potential of providing more efficient, safer and cost-effective chemotherapeutics for treatment of even the most stringent forms of breast cancer (metastatic and triple negative). cache = ./cache/cord-255460-r5p5helx.txt txt = ./txt/cord-255460-r5p5helx.txt === reduce.pl bib === id = cord-255807-7goz1agp author = Hak, E. title = Conventional Influenza Vaccination Is Not Associated with Complications in Working-Age Patients with Asthma or Chronic Obstructive Pulmonary Disease date = 2003-04-15 pages = extension = .txt mime = text/plain words = 4312 sentences = 194 flesch = 41 summary = By using a nested case-control design, the authors studied the effectiveness of the influenza vaccine in reducing severe and fatal complications in 4,241 and 5,966 primary care, working-age patients aged 18–64 years who had asthma or chronic obstructive pulmonary disease during the 1998–1999 and 1999–2000 influenza epidemics in the Netherlands. The risk of influenza-related morbidity and mortality during influenza epidemics is high (1) (2) (3) (4) , and nonexperimental studies have shown that vaccination against influenza prevents respiratory and cardiac complications during epidemics in elderly patients with chronic obstructive pulmonary disease (COPD) (5, 6) . We determined the occurrence of respiratory and cardiac morbidity during influenza periods and the clinical effectiveness of vaccination in reducing these complications in patients aged 18-64 years who had asthma or COPD by using a prospective, nested case-control design. cache = ./cache/cord-255807-7goz1agp.txt txt = ./txt/cord-255807-7goz1agp.txt === reduce.pl bib === id = cord-010119-t1x9gknd author = nan title = Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date = 2017-09-04 pages = extension = .txt mime = text/plain words = 230193 sentences = 13234 flesch = 55 summary = Conclusion: The wide distribution in the concentration of bioactive lipids among 405 stored RBC units suggests that lipid degradation is highly donor-Background/Case Studies: To ensure availability of biological products to hospitals, blood banks have developed and validated multiple storage conditions for each of their products to maximize shelf life and quality. 1 The Department of Blood Transfusion, The PLA General Hospital, 2 The Department of Blood Transfusion, Air Force General Hospital, PLA Background/Case Studies: Recently, multi researches have reported that longer term-stored red blood cells(RBCs) units were associated with increased risks of clinically adverse events, especially in critically ill patients. Weak D types 1, 2 and 3 express all the major RhD epitopes and these patients can be managed as RhD-positive, which may lead to a reduction in unnecessary Rh immunoglobulin (RhIG) administration and conservation of RhD-negative RBCs. Study Design/Method: RHD genotyping was performed on all patient samples with weaker than expected or discrepant RhD typing results, utilizing a commercially available genotyping kit manufactured by Immucor (RHD BeadChip). cache = ./cache/cord-010119-t1x9gknd.txt txt = ./txt/cord-010119-t1x9gknd.txt === reduce.pl bib === id = cord-256030-5xzuilc1 author = Michel, Pierre-Antoine title = Home hemodialysis during the COVID-19 epidemic: comment on the French experience from the viewpoint of a French home hemodialysis care network date = 2020-11-11 pages = extension = .txt mime = text/plain words = 1749 sentences = 74 flesch = 47 summary = According to the data from the French Biomedicine Agency, during the peak period of the epidemic, between March 1 and June 15, 2020, only 7 of the 423 patients on home hemodialysis in France were diagnosed with COVID-19; the incidence is similar to that observed in patients treated with peritoneal dialysis (1.8%). For instance, in the Ile de France region, one of the most affected by the pandemic, data from the Biomedicine Agency indicate that 930 out of 8,025 patients (11.5%) on in-center hemodialysis were diagnosed with COVID-19, whereas only 4 out of 109 patients on home hemodialysis developed the disease (3.6%) (p = 0.001). Furthermore, globally 52 of our 55 patients later agreed to have a SARS-CoV-2 serology test performed, which was positive in the 2 patients Therefore, within the limits of a small series, and while waiting for additional data, we would like to confirm that our experience underlines the importance of developing an efficient home hemodialysis network, able to patients in a time of epidemic. cache = ./cache/cord-256030-5xzuilc1.txt txt = ./txt/cord-256030-5xzuilc1.txt === reduce.pl bib === === reduce.pl bib === id = cord-256290-pyrmtps3 author = Kerr, Colm title = Prevalence of smell and taste dysfunction in a cohort of CoVID19 outpatients managed through remote consultation from a large urban teaching hospital in Dublin, Ireland date = 2020-07-15 pages = extension = .txt mime = text/plain words = 1348 sentences = 85 flesch = 57 summary = Assessment of smell and taste function should be conducted at the point of CoVID19 testing to further investigate their association with disease presence. At the time of our study, The European Centre for Disease Prevention and Control did not specifically delineate taste and smell disturbances as features of CoVID19. As such, our study investigated the prevalence of these features in a cohort of newly diagnosed COVID19 patients triaged to management in an outpatient setting through a telephone clinic. Our study has found that, in a cohort of patients with confirmed mild CoVID19 disease suitable for remote medical management, approximately half of them experienced new onset smell or taste dysfunction. Further work should also investigate the prevalence of olfactory and gustatory disturbance in all patients being tested for CoVID19, in order to evaluate the diagnostic value of these features in predicting the presence of the disease. cache = ./cache/cord-256290-pyrmtps3.txt txt = ./txt/cord-256290-pyrmtps3.txt === reduce.pl bib === id = cord-256888-tdx12ccj author = Bradley, Benjamin T title = Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series date = 2020-07-16 pages = extension = .txt mime = text/plain words = 5006 sentences = 300 flesch = 45 summary = To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling. 8 Post-mortem studies have shown pulmonary, renal, and small vessel injury, with particles resembling virus observed in the kidney by electron microscopy. By electron microscopy, aggregates of uniform, round enveloped particles ranging in size from around 70 nm to 100 nm with peripheral spike-like projections consistent with the morphology described for SARS-CoV-2 were observed in the lung, trachea, kidney, and large intestine of patient 8 and patient 13. [9] [10] [11] [12] We present a case series of autopsy findings in 14 patients who died after SARS-CoV-2 infection. The major histopathological observation in our series of patients who died with COVID-19 was diffuse alveolar damage-type lung injury in the acute or organising phases (12 [86%] of 14 patients). cache = ./cache/cord-256888-tdx12ccj.txt txt = ./txt/cord-256888-tdx12ccj.txt === reduce.pl bib === id = cord-257035-ob1xncbs author = Rigatelli, Gianluca title = Intubation and Ventilation amid COVID-19: Comment date = 2020-05-11 pages = extension = .txt mime = text/plain words = 730 sentences = 47 flesch = 43 summary = The recent published literature regarding the occurrence of acute respiratory syndrome (ARDS) in COVID-19 patients have mainly focused attention on the role of computed tomography in evaluating the radiological manifestations and temporal progression of the disease, 2 while few data have been presented regarding the use of lung ultrasonography, 3 especially in the evaluation of the disease course. have recently highlighted that lung recruitability can be effectively assessed bedside in COVID-19 patients with ARDS. The authors did not report data regarding the use of lung ultrasonography for the cited purposes. Since treatment of severe ARDS from COVID-19 is an ongoing challenge, it is important to learn from the patients who have been treated to gain an understanding of the disease's epidemiology, its biologic mechanisms, and the effects of new pharmacologic interventions. Lung ultrasound can be used to predict the potential of prone positioning and assess prognosis in patients with acute respiratory distress syndrome cache = ./cache/cord-257035-ob1xncbs.txt txt = ./txt/cord-257035-ob1xncbs.txt === reduce.pl bib === id = cord-256618-tt3p0tki author = Liao, Yun title = Role of pharmacists during the COVID‐19 pandemic in China ‐ Shanghai Experiences date = 2020-06-14 pages = extension = .txt mime = text/plain words = 2484 sentences = 155 flesch = 46 summary = They work with pharmacists at SPHCC, having responsibilities that include drug supplies, dispensing, pharmacy intravenous admixture services (PIVAS), prescription audits, medication reconciliations, pharmacotherapy, therapeutic drug monitoring, and patient education. Fangcang, which sounds similar to Noah's Ark in Chinese, is a large, temporary hospital built by converting public venues, such as stadiums and exhibition halls, into health care facilities to isolate patients with mild to moderate symptoms of an infectious disease from their families and communities, while providing medical care, disease monitoring, food, shelter, and social activities. They work with the 35 pharmacists and 5 clinical pharmacists at SPHCC, having responsibilities over drug supplies, dispensing, pharmacy intravenous admixture services (PIVAS), prescription audits, medication reconciliations, pharmacotherapy, therapeutic drug monitoring (TDM), and patient education. According to the criteria stated in the "Expert Consensus on Comprehensive Treatment of COVID-19 in Shanghai", 4 individuals with an epidemiological history (resided in or visited an epidemic area within 14 days) and clinical symptoms (fever or respiratory symptoms, imaging features, decreased lymphocyte count) are considered suspected cases. cache = ./cache/cord-256618-tt3p0tki.txt txt = ./txt/cord-256618-tt3p0tki.txt === reduce.pl bib === id = cord-256508-ce59ovan author = Asselah, Tarik title = COVID-19: discovery, diagnostics and drug development date = 2020-10-08 pages = extension = .txt mime = text/plain words = 9214 sentences = 556 flesch = 46 summary = To date, with the exception of intravenous Remdesivir and dexamethasone, which have modest effects in moderate to severe COVID-19, no strong clinical evidence supports the efficacy and safety of any other drugs against SARS-CoV-2. The current diagnostic strategy to identify patients with COVID-19 is to test samples taken from the respiratory tract to assess for the presence of SARS-CoV-2 specific nucleic acid targets [47] . The neutralization assay is a laboratory-based test that uses live virus and cell culture methods to determine if patient antibodies can prevent viral infection in vitro [72] . A randomized, controlled, openlabel trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection and severe respiratory illness COVID-19 was performed [126] . Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals cache = ./cache/cord-256508-ce59ovan.txt txt = ./txt/cord-256508-ce59ovan.txt === reduce.pl bib === id = cord-256535-fz5p2u6p author = Oki, Sogo title = Long-Term Clinical Outcome and Prognosis After Thrombectomy in Patients With Concomitant Malignancy date = 2020-10-15 pages = extension = .txt mime = text/plain words = 3376 sentences = 166 flesch = 47 summary = Among the eight patients who survived more than 2 weeks from onset, four patients showed good clinical outcome [modified Rankin Scale (mRS) <2] at 60 days posttreatment and were able to continue treatment for malignancy. The development of endovascular thrombectomy (EVT) is a recent advancement, and numerous randomized clinical trials have proved the efficacy of EVT for the treatment of acute ischemic stroke (AIS) in patients with large vessel occlusion (LVO) (6) (7) (8) (9) (10) (11) . Patient information, including age, sex, location of malignancy, cell type, cancer staging, malignancy treatment before stroke onset, concomitant stroke risk factors (hypertension, diabetes, hyperlipidemia, atrial fibrillation, pulmonary embolism or deep venous thrombosis, and previous history of stroke), premorbid antiplatelet/anticoagulant drug, and blood D-dimer level at admission (17) were obtained from the medical records. cache = ./cache/cord-256535-fz5p2u6p.txt txt = ./txt/cord-256535-fz5p2u6p.txt === reduce.pl bib === id = cord-255805-wlr8nod3 author = Liu, Yan title = Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19: A case report date = 2020-10-16 pages = extension = .txt mime = text/plain words = 3830 sentences = 202 flesch = 43 summary = The clinical data and the evolution of the disease process of a critical novel coronavirus pneumonia patient who has been successfully treated by mechanical ventilation through tracheal intubation in the intensive care isolation ward of Taihe Hospital in Shiyan City (Hubei Medical College Affiliated Hospital) were analyzed and summarized, to provide a clinical reference for the diagnosis and treatment of critical COVID-19 patients. On March 22, the patient again performed bedside bronchoscopy to clear the airway secretions and successfully removed the tracheal intubation, given nasal high-flow oxygen therapy and continued to anti-infection, airway management, nutritional support, immunity enhancement, and respiratory function exercises treatment. [6] [7] [8] In this case, as the patients condition developed and progressed, the patients diagnosis, which was based on imaging, blood gas analysis and other tests, had been considered secondary bronchial fistula, bacterial lung infection, and acute respiratory distress syndrome (ARDS): persistent carbon dioxide retention and hypercarbonemia after mechanical ventilation by endotracheal intubation. cache = ./cache/cord-255805-wlr8nod3.txt txt = ./txt/cord-255805-wlr8nod3.txt === reduce.pl bib === id = cord-255652-3n2dxljj author = Challener, Douglas W. title = Screening for COVID-19: Patient factors predicting positive PCR test date = 2020-05-19 pages = extension = .txt mime = text/plain words = 1162 sentences = 67 flesch = 50 summary = title: Screening for COVID-19: Patient factors predicting positive PCR test SARS-CoV-2, the novel coronavirus causing COVID-19, was isolated in patients from Wuhan, China, in December 2019 and sparked a global pandemic in early 2020. At the Mayo Clinic in Rochester, Minnesota, we began screening patients for COVID-19 on a large scale on March 12, 2020, after Minnesota's first case was reported on March 10, 2020. The COVID-19-negative patients were selected in a random fashion by matching age (±5 years), sex, collection date, and testing location (Minnesota, Wisconsin, or Arizona) with the positive patients. This study investigates the results of testing ambulatory patients in a relatively low prevalence area in early March 2020 and suggests that exposure to the disease is more predictive of a positive test than any examined symptom. In this analysis, exposure to confirmed SARS-CoV-2 and recent travel were both significantly more predictive of a positive test than the presence of any symptoms. cache = ./cache/cord-255652-3n2dxljj.txt txt = ./txt/cord-255652-3n2dxljj.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-257206-av2k44ig author = Chen, Ruey title = Effects of a SARS prevention programme in Taiwan on nursing staff's anxiety, depression and sleep quality: A longitudinal survey date = 2006-02-28 pages = extension = .txt mime = text/plain words = 5064 sentences = 278 flesch = 59 summary = Abstract The aim of this research is to determine the levels of anxiety, depression, and sleep quality a severe acute respiratory syndrome (SARS) nursing staff experienced before and after a SARS prevention program. Using general estimating equations (GEE) statistical analysis to control possible for affecting factors, we found that the nursing staff's anxiety and depression along with sleep quality started to improve 2 weeks after the initiation of SARS prevention controls. This research is to describe the anxiety level, depression level, and sleep quality of nursing staff who cared for SARS patients during a sweeping epidemic and the effects of a SARS prevention program. Tables 2 and 3 show the effects of the SARS prevention program on nursing staff through their self-reported levels of anxiety and depression as well as sleep quality. cache = ./cache/cord-257206-av2k44ig.txt txt = ./txt/cord-257206-av2k44ig.txt === reduce.pl bib === id = cord-256556-1zea3wa1 author = Lou, Yan title = Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial date = 2020-10-25 pages = extension = .txt mime = text/plain words = 4228 sentences = 225 flesch = 50 summary = The percentage of patients who turned viral negative after 14-day treatment was 70%, 77%, and 100% in the baloxavir marboxil, favipiravir, and control group respectively, with the medians of time from randomization to clinical improvement was 14, 14 and 15 days, respectively. Then, an exploratory single center, open-label, randomized, controlled trial was conducted to evaluate the efficacy and safety of adding baloxavir marboxil or favipiravir to the current standard antiviral treatment in patients confirmed as COVID-19 who are still positive for the SARS-CoV-2 (ChiCTR2000029544). This trial was an exploratory single center, open-label, randomized, controlled trial to evaluate the efficacy and safety of adding baloxavir marboxil or favipiravir to the current standard antiviral treatment in patients confirmed as COVID-19 who are still positive for the SARS-CoV-2 (ChiCTR2000029544). The activity against SARS-CoV-2 was tested in vitro for the antiviral drugs used in this trial, including arbidol, ritonavir, lopinavir, darunavir, baloxavir acid, and favipiravir. cache = ./cache/cord-256556-1zea3wa1.txt txt = ./txt/cord-256556-1zea3wa1.txt === reduce.pl bib === id = cord-256849-8w2avwo2 author = Koenig, Kristi L. title = Identify-Isolate-Inform: A Tool for Initial Detection and Management of Measles Patients in the Emergency Department date = 2015-03-18 pages = extension = .txt mime = text/plain words = 2864 sentences = 172 flesch = 52 summary = title: Identify-Isolate-Inform: A Tool for Initial Detection and Management of Measles Patients in the Emergency Department The "Identify-Isolate-Inform" tool will assist emergency physicians to be better prepared to detect and manage measles patients presenting to the emergency department. Emergency physicians must rapidly inform the local public health department and hospital infection control personnel of suspected measles cases. Following a brief review of measles, this paper describes the novel 3I tool, initially developed for Ebola virus disease, 4 as adapted for use in the initial detection and management of measles patients in the emergency department (ED). During a measles outbreak, after donning appropriate respiratory protection, emergency physicians (EP) should carefully assess the oropharynx in patients presenting with non-specific viral syndromes and assess for the presence of Koplik spots. 12 Conversely, patients with signs and symptoms of measles (prodrome of fever, cough/coryza/conjunctivitis, Koplik spots followed by rash), should be immediately masked and isolated using airborne precautions. cache = ./cache/cord-256849-8w2avwo2.txt txt = ./txt/cord-256849-8w2avwo2.txt === reduce.pl bib === id = cord-256639-4e0irb6d author = Jean-Michel, Vanessa title = Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation date = 2020-09-06 pages = extension = .txt mime = text/plain words = 842 sentences = 61 flesch = 49 summary = title: Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation The Food and Drug Administration recently issued a midazolam shortage and reported a more than 50% consumption increase for other common sedative drugs such as propofol due to high demand for patients with COVID-19 [3] . For these patients, barbiturate therapy induce deep coma with bispectral index score lower than 20 and, as a result, prolonged MV [4] . Midazolam and propofol were completely stopped one hour after the thiopental loading dose in all patients. Another drug option for sedation of critically ill patients with COVID-19 could be inhaled volatile anaesthetics [9, 10] . Some studies have reported that inhaled agents such as isoflurane and sevoflurane shorten awakening and extubation times in mechanically ventilated patients compared to benzodiazepines or propofol. Thiopental seems to be an acceptable substitute to sedative drugs in this period of high midazolam and propofol demand for ICU patients with COVID-19. cache = ./cache/cord-256639-4e0irb6d.txt txt = ./txt/cord-256639-4e0irb6d.txt === reduce.pl bib === id = cord-256893-3sh87h2x author = Yang, Li title = COVID-19: immunopathogenesis and Immunotherapeutics date = 2020-07-25 pages = extension = .txt mime = text/plain words = 5347 sentences = 300 flesch = 42 summary = The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. The number of people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is rapidly increasing worldwide. The effect of elevated cytokine production on clinical manifestations Increasing evidence shows that viral infection can induce severe syndromes of shock and organ failure; 8,57 this phenomenon was also investigated for COVID-19. Treg cell-based therapy The dysregulated inflammatory processes caused by SARS-CoV-2 in patients with severe COVID-19 are partially due to the dysfunction of Tregs, which are responsible for inhibiting inflammation. cache = ./cache/cord-256893-3sh87h2x.txt txt = ./txt/cord-256893-3sh87h2x.txt === reduce.pl bib === === reduce.pl bib === id = cord-257147-i48qljv6 author = Karakas, Mahir title = Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) date = 2020-08-11 pages = extension = .txt mime = text/plain words = 3501 sentences = 191 flesch = 47 summary = Clinical information for the 8 patients before and after the Adrecizumab administration was obtained from the hospital information system and included the following: demographic data, including anamnesis and physical examination; treatment and therapies, including mechanical ventilation and antiviral therapies; clinical data, including PaO2/FiO2, the SOFA score (range 0-24, with higher scores indicating a more severe illness), and the SAPS-II score (higher scores indicating a more severe illness); and laboratory data, including bio-ADM, DPP3, the white blood cell count, lactate, the liver and kidney function, and inflammatory factors (CRP, procalcitonin, and interleukin-6). In this preliminary uncontrolled case series of eight extreme-critically ill patients with COVID-19 and ARDS, the administration of the non-neutralizing anti-ADM antibody Adrecizumab was followed by a favorable outcome. In this preliminary uncontrolled case series of eight extreme-critically ill patients with COVID-19 and ARDS, the administration of the non-neutralizing anti-ADM antibody Adrecizumab was followed by a favorable outcome. cache = ./cache/cord-257147-i48qljv6.txt txt = ./txt/cord-257147-i48qljv6.txt === reduce.pl bib === === reduce.pl bib === id = cord-256856-jw1d6uig author = Sohinki, Daniel title = What Coronavirus Disease 2019 Has Taught Us About Modern Electrophysiology Practice date = 2020-08-15 pages = extension = .txt mime = text/plain words = 2070 sentences = 104 flesch = 40 summary = EP seems uniquely suited to adopt telemedicine as a care delivery platform as an undeniably technical specialty that is increasingly reliant on objective, preacquired data in a manner that does not require the patient to physically interact with a physician to share in clinical decision-making (Figure 1) . 1 A large study using Consumer Assessment of Healthcare Providers and Systems data demonstrated no difference in patient satisfaction when comparing in-person and telehealth visits. These results can then be communicated to the physician via electronic health records, fax, secure messaging, or the telemedicine platform itself, thereby ensuring longitudinal care. Today, however, with the advent of smartphone and smartwatch technologies, consumer electronics have become an attractive modality for ambulatory ECG recording, capable of rapid, high-quality rhythm strip acquisition and transmission, enabling remote physician review. Patient satisfaction management in office visits and telehealth in health care technology. cache = ./cache/cord-256856-jw1d6uig.txt txt = ./txt/cord-256856-jw1d6uig.txt === reduce.pl bib === === reduce.pl bib === id = cord-257717-fbfe5vt4 author = Wallis, Christopher J.D. title = The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future date = 2020-09-04 pages = extension = .txt mime = text/plain words = 7908 sentences = 371 flesch = 35 summary = EVIDENCE ACQUISITION: A collaborative narrative review was conducted using literature published through May 2020 (PubMed), which comprised three main topics: reduced in-person interactions arguing for increasing virtual and image-based care, optimisation of the delivery of care, and the effect of COVID-19 in health care facilities on decision-making by patients and their families. Several themes emerged during the COVID-19 pandemic that would be critical or beneficial to genitourinary cancer care in the future ( Fig. 1) : first, reduced in-person interactions argued for increasing virtual and image-based care; second, optimising the delivery of care to include better triage, understanding and addressing mental health implications due to less in-person care, and maintaining high-quality research and education endeavours are necessary; and third, the presence of SARS-CoV-2 in health care facilities may affect decision-making by patients and their families. cache = ./cache/cord-257717-fbfe5vt4.txt txt = ./txt/cord-257717-fbfe5vt4.txt === reduce.pl bib === id = cord-257600-0plhquk9 author = Calles, Antonio title = Outcomes of COVID-19 in Patients With Lung Cancer Treated in a Tertiary Hospital in Madrid date = 2020-09-16 pages = extension = .txt mime = text/plain words = 6981 sentences = 353 flesch = 47 summary = Differences in health-care systems, in the incidence and prevalence of SARS-CoV-2 infection by geographic regions, and patient access to intensive support care -including MVand treatment with antivirals or anti-IL6/IL1 agents may ultimately influence outcomes in patients with lung cancer affected by COVID-19. We aimed to describe the clinical characteristics of lung cancer patients with COVID-19 attended in a tertiary hospital in Madrid, one of the most hit regions by coronavirus in the world so far, and analyze factors associated with worse outcome, including type of treatment receiving at the time of COVID-19 diagnosis. We performed SARS-CoV-2 RT-PCR to every suspicious case and included all lung cancer patients attended at our hospital (emergency room, hospitalization, ambulatory office, day care area). Data from Wuhan, in China, showed that active cancer treatment received in the 14 days before SARS-CoV-2 infection had an increase on the risk of severe outcomes of COVID-19 (HR 4.079, 95%CI, 1.086-15.322; p = 0.037) (9) . cache = ./cache/cord-257600-0plhquk9.txt txt = ./txt/cord-257600-0plhquk9.txt === reduce.pl bib === id = cord-258027-f3rr5el1 author = Østby, Anne‐Cathrine title = Respiratory virology and microbiology in intensive care units: a prospective cohort study date = 2013-05-18 pages = extension = .txt mime = text/plain words = 5259 sentences = 268 flesch = 38 summary = Our aim was to determine the frequency of 12 common respiratory viruses in patients admitted to intensive care units with respiratory symptoms, evaluate the clinical characteristics and to compare the results to routine microbiological diagnostics. The information included the following: age, gender, underlying comorbidity, use of immunosuppressant drugs, respiratory symptoms, diagnoses on admission, diagnoses on discharge, length of hospital stay, ICU stay and intubation, Simplified Acute Physiology Score II (SAPS II)scores, administration of antibiotics, non-invasive ventilation, chest x-ray, laboratory analyses and results of the physical examination, which included temperature, saturation, stethoscopic findings and clinical signs of respiratory infection or distress. Viruses -Of the 122 patients included in the study group, 19 (16%) were positive for a virus, of which the most frequently detected were influenza A (n = 9) and RSV (n = 3, Fig. 2 ). cache = ./cache/cord-258027-f3rr5el1.txt txt = ./txt/cord-258027-f3rr5el1.txt === reduce.pl bib === === reduce.pl bib === id = cord-257344-d13at1y5 author = Ghasemiyeh, Parisa title = COVID-19 Outbreak: Challenges in Pharmacotherapy Based on Pharmacokinetic and Pharmacodynamic Aspects of Drug Therapy in Patients with Moderate to Severe Infection date = 2020-09-18 pages = extension = .txt mime = text/plain words = 5683 sentences = 297 flesch = 41 summary = Patients with predisposing diseases are highly prone to COVID-19 and manifesting severe infection especially with organ function damage such as acute respiratory distress syndrome, acute kidney injury, septic shock, ventilator-associated pneumonia, and death. Patients with underlying diseases are highly prone to present with severe infection especially with organ function damage such as acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), septic shock, and ventilator-associated pneumonia (VAP) 10, 13 . Results of another systematic review and meta-analysis on 53 randomized clinical trials on administration of hydroxychloroquine in COVID-19 management revealed that hydroxychloroquine administration (case group) was significantly associated with higher incidence of total adverse effects in comparison to placebo or no treatment (control group) in overall population of patients with COVID-19 45 . Almost all of the potential drugs in COVID-19 treatment containing chloroquine, hydroxychloroquine, ribavirin, and lopinavir/ritonavir have hepatic metabolism. cache = ./cache/cord-257344-d13at1y5.txt txt = ./txt/cord-257344-d13at1y5.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-257051-ntnfu5ns author = Tack, Christopher Topol title = “Physio Anywhere”: digitally-enhanced outpatient care as a legacy of coronavirus 2020 date = 2020-07-18 pages = extension = .txt mime = text/plain words = 1380 sentences = 77 flesch = 40 summary = Remote working via telemedicine (telephone or video-assisted consultation) displaces the need for face-to-face contact whilst providing care within patients' own homes [2] . Despite the relative infancy of remote working in physiotherapy, there is an emerging body of evidence that supports its incorporation in clinical practice as both an assessment and rehabilitation tool. However, telemedicine, aided by an ever-increasing number of digital health tools, can significantly increase patients' confidence in undertaking exercise and improve compliance and adherence to exercise-based rehabilitation programmes, compared to usual physiotherapy care [21] [22] . Digital health tools provide images and videos J o u r n a l P r e -p r o o f of exercises, patient advice and education and include reminders for patients to carry out prescribed exercise programs given by their physiotherapist in a 'virtual' exercise class, which can be remotely delivered and adherence monitored. cache = ./cache/cord-257051-ntnfu5ns.txt txt = ./txt/cord-257051-ntnfu5ns.txt === reduce.pl bib === id = cord-258293-7q9zj8c2 author = Marini, Alessandra title = Letter to the Editor Regarding 'Coronavirus Disease 2019 (COVID-19) and Neurosurgery: Literature and Neurosurgical Societies Recommendations Update' date = 2020-05-26 pages = extension = .txt mime = text/plain words = 921 sentences = 52 flesch = 46 summary = with intracranial or spinal oncological pathology (rapidly evolving intracranial hypertension with deteriorating 4 state of consciousness, acute hydrocephalus, spinal cord compression with rapid tetra or paraparesis); Class A + 5 are the patients who requirie treatment within a maximum of 7-10 days, with intracranial tumors with mass 6 effect or with progressive neurological deficit, without deterioration of consciousness and patients requiring 7 treatment within a month, namely Class A, with neurological alteration or suspected malignant lesion, related 8 This resulted in progression of the neurological 4 symptoms, without an early neurosurgical evaluation, until the onset of acute deficit which actually led to the 5 emergency room access. symptoms were consciousness alteration and seizures; in our survey approximately 10,7 % of the acute-onset 0 patients reported to have previously refused the surgical treatment, in the weeks before, correlated to concerns 1 about the hospitalization during the Coronavirus emergency. In conclusion, during the COVID-19 pandemic the neurosurgical urgent and emergency onset of neuro-6 oncological cases increased, in comparison to 2019. Illustrative Table regarding the epidemiological variations in neuro-oncological patients' onset during the COVID-19 crisis cache = ./cache/cord-258293-7q9zj8c2.txt txt = ./txt/cord-258293-7q9zj8c2.txt === reduce.pl bib === id = cord-258067-par61wwh author = Di Martino, Marcello title = Elective Surgery During the SARS-CoV-2 Pandemic (COVID-19): A Morbimortality Analysis and Recommendations on Patient Prioritisation and Security Measures date = 2020-06-20 pages = extension = .txt mime = text/plain words = 3464 sentences = 178 flesch = 42 summary = Conclusions The patients undergoing the surgical procedures showed high rates of COVID-19 infection and postoperative complications, especially the patients with oncological diseases. The following variables were analysed: age; sex; functional status (defined according to the ECOG scale) (21); personal background; diagnosis; type of surgical intervention; the timing of SARS-CoV-2 infection; the treatment required (Table 1) ; the severity of the respiratory infection (according to the BRCSS) (20) ; and postoperative complications (according to the Dindo-Clavien classification) (19) . Ten (16.9%) of the oncological patients, one (1%) of those operated on electively for benign diseases and four (7%) of the urgent surgery group presented with a SARS-CoV-2 infection, with statistically significant differences in the infection rate of the three groups (p = 0.004) ( Table 2) . Patients undergoing elective surgery before and during the peak of the COVID-19 pandemic showed a high rate of postoperative complications, with a SARS-CoV-2 infection rate of up to 16% in patients undergoing oncologic surgical procedures. cache = ./cache/cord-258067-par61wwh.txt txt = ./txt/cord-258067-par61wwh.txt === reduce.pl bib === === reduce.pl bib === id = cord-257467-b8o5ghvi author = Smith, Barbara A. title = Anesthesia as a Risk for Health Care Acquired Infections date = 2010-12-31 pages = extension = .txt mime = text/plain words = 4506 sentences = 276 flesch = 42 summary = This article further discusses the risks for HAIs apparent in intravascular cannulation, endotracheal intubation, and the development of surgical site infections, and examines occupational measures to prevent infections in the health care worker. Although endotracheal intubation during surgery is generally a controlled safe procedure, this artificial airway predisposes the body to exposure to respiratory pathogens whether from the health care provider, the environment, or equipment. 12 A recent practice advisory prepared by the American Society of Anesthesiologists (ASA) concurs with the implementation of aseptic technique when handling neuraxial needles and catheters, and states it should include "hand washing, wearing of sterile gloves, wearing of caps, wearing of masks covering both the mouth and nose, use of individual packets of skin preparation, and sterile draping of the patient." The same advisory does not make a specific recommendation regarding the type of skin antisepsis to use. cache = ./cache/cord-257467-b8o5ghvi.txt txt = ./txt/cord-257467-b8o5ghvi.txt === reduce.pl bib === id = cord-258278-25rhf91v author = Mowla, Ashkan title = Unusual Pattern of Arterial Macrothrombosis Causing Stroke in a Young Adult Recovered from COVID-19 date = 2020-09-25 pages = extension = .txt mime = text/plain words = 2052 sentences = 107 flesch = 46 summary = Herein, we report a 36-year-old man with no significant past medical history who recently recovered from a mild COVID-19 infection and presented with unusual pattern of arterial macrothrombosis causing AIS. However, most of these patients had significant co-morbidities and established cardiovascular risk factors, making it difficult to confirm COVID-19 as the precipitating cause (3) While coagulopathy and vascular endothelial dysfunction have been widely reported as a consequence of severe COVID-19 infection, these findings are proposed to be directly related to the severity of the respiratory illness, (4) and the prevalence of this prothrombotic state among milder or asymptomatic cases is not yet established. Herein, we report an unusual pattern of arterial macrothrombosis presenting as large vessel stroke in a 36-year-old patient with no prior medical history (PMH) who had recently recovered from a mild COVID-19 infection. In conclusion, we report a young adult with no underlying comorbidities who recently recovered from COVID-19 infection and presented with AIS due to multicentric large vessel occlusion. cache = ./cache/cord-258278-25rhf91v.txt txt = ./txt/cord-258278-25rhf91v.txt === reduce.pl bib === id = cord-257781-ybpliz32 author = Jones, Eben title = Subcutaneous Emphysema, Pneumomediastinum, and Pneumothorax in Critically Ill Patients With Coronavirus Disease 2019: A Retrospective Cohort Study date = 2020-09-17 pages = extension = .txt mime = text/plain words = 3472 sentences = 190 flesch = 44 summary = IMPORTANCE: Management of severe coronavirus disease 2019 relies on advanced respiratory support modalities including invasive mechanical ventilation, continuous positive airway pressure, and noninvasive ventilation, all of which are associated with the development of subcutaneous emphysema, pneumomediastinum, and pneumothorax (herein collectively termed barotrauma). Barotrauma cases had longer illness duration prior to critical care admission (10 vs 7 d; interquartile range, 8–14 and 6–10, respectively; p = 0.073) and were more often treated with continuous positive airway pressure or noninvasive ventilation as the initial modality of advanced respiratory support (87.5% vs 36.0%; p = 0.007). Subcutaneous emphysema, pneumomediastinum, and pneumothorax-herein collectively termed "barotrauma" (referring to the manifestation, rather than etiologic mechanism, of airway tract damage and resultant extra-alveolar air)-are known complications of all forms of positive pressure respiratory support and are associated with multiple organ failure and death (6) . cache = ./cache/cord-257781-ybpliz32.txt txt = ./txt/cord-257781-ybpliz32.txt === reduce.pl bib === id = cord-257839-kfzc4pwq author = Ferguson, Katie title = COVID-19 associated with extensive pulmonary arterial, intracardiac and peripheral arterial thrombosis date = 2020-08-03 pages = extension = .txt mime = text/plain words = 2800 sentences = 176 flesch = 48 summary = We present this case to highlight the extensive COVID-19-associated thrombotic complications that can occur, even despite periods of high-dose prophylactic and therapeutic anticoagulation. In recent case series, elevated D-dimer levels were reported in 43% 6 of the patients and were associated with disease severity and increased mortality. 5 Findings that shed new light on the possible pathogenesis of a disease or an adverse effect Several case series exist which explore the incidence of venous and arterial thrombosis in patients with COVID-19. 10 The latter includes a study of 10 ICU patients with COVID-19 pneumonia in whom D-dimer levels and viscoelastic measures reduced in response to increased prophylactic dosing. [11] [12] [13] Twitter Nathaniel Quail @DrNatQuail and Kevin G Blyth @kevingblyth Acknowledgements Dr Joe Sarvesvaran's care and compassion were integral to this patient's journey to recovery and we would like to acknowledge his support with writing this case report, and for selecting the key images to include. cache = ./cache/cord-257839-kfzc4pwq.txt txt = ./txt/cord-257839-kfzc4pwq.txt === reduce.pl bib === id = cord-258416-1jrbu8ox author = Drenovska, Kossara title = Covid‐19 pandemic and the skin date = 2020-09-21 pages = extension = .txt mime = text/plain words = 1977 sentences = 121 flesch = 40 summary = Following patients with psoriasis on biological therapy, as well as other inflammatory and autoimmune cutaneous disorders such as atopic dermatitis, pemphigus, pemphigoid diseases, and skin cancer provoked the interest of dermatologists. Here, we summarize skin conditions during the COVID‐19 pandemic, patient information, and expert recommendations and give an overview about the registries launched to document skin changes during COVID‐19, as well as details about certain patient groups infected with SARS‐CoV‐2, for example, psoriasis, atopic dermatitis, and autoimmune bullous diseases. 33 In a French prospective study on the incidence and types of COVID-19-associated cutaneous manifestations, skin involvement was reported in only 4.9% (five patients of 103) and presented as erythematous rash (two patients) and urticaria (two patients). Future case-controlled studies may potentially confirm AGA as a predictive factor for increased COVID-19 severity and contribute to the development of antiandrogen therapy for SARSNeonatal rashes Skin rashes in newborns of COVID-19-infected mothers were reported in two boys out of four infants from China. cache = ./cache/cord-258416-1jrbu8ox.txt txt = ./txt/cord-258416-1jrbu8ox.txt === reduce.pl bib === id = cord-256634-gg8hptfg author = Rhodes, N. J. title = Multicenter point-prevalence evaluation of the utilization and safety of drug therapies for COVID-19 date = 2020-06-06 pages = extension = .txt mime = text/plain words = 4107 sentences = 260 flesch = 50 summary = Conclusions: While we observed high rates of supportive care for patients with COVID-19, we also found that ADRs were common among patients receiving drug therapy including in clinical trials. The objective of this point-prevalence study was to characterize the drug therapies used in the management of COVID-19, including supportive care and combination therapies, in an attempt to identify safety signals among acutely ill hospitalized patients. Data elements collected included facility demographics, total number of hospital and ICU beds prior to the pandemic, U.S. Census region location, patient populations served, facility type (e.g., academic, community, inpatient rehabilitation), and active clinical trial site status. In addition to whether patients were receiving supportive care or drug therapies targeted at SARS-CoV-2, we collected basic patient demographic information and vital status (e.g., age, sex, comorbidities, oxygen requirement, and ICU status). Patients were significantly more likely to receive COVID-19 directed drug therapy if they were enrolled in a clinical trial (26.9% vs 3.2%; P <0.001). cache = ./cache/cord-256634-gg8hptfg.txt txt = ./txt/cord-256634-gg8hptfg.txt === reduce.pl bib === === reduce.pl bib === id = cord-257732-3xuy6tbn author = Azzi, Lorenzo title = Saliva is a reliable tool to detect SARS-CoV-2 date = 2020-04-14 pages = extension = .txt mime = text/plain words = 3510 sentences = 201 flesch = 56 summary = OBJECTIVES: This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data. At present, Real Time reverse transcription Polymerase Chain Reaction (rRT-PCR) on respiratory specimens represents the gold standard test for detection of SARS-CoV-2 infection. 10 , 11 Sputum and oropharyngeal secretions have recently been suggested as a possible target for the molecular diagnosis of COVID-19, 12 and salivary droplets represent the main source of the human-to-human transmission of the SARS-CoV-2 infection when social distance is less than 2 m. There were not significant differences regarding the clinical and anamnestic history between males and females, with the only exception of the values of serum LDH, which were higher in the female patients' haematochemical analyses carried out on the day of saliva collection ( p = 0.025). cache = ./cache/cord-257732-3xuy6tbn.txt txt = ./txt/cord-257732-3xuy6tbn.txt === reduce.pl bib === id = cord-257336-rpx71ww5 author = Doukas, Sotirios G. title = E-cigarette or vaping induced lung injury: A case series and literature review date = 2020-10-03 pages = extension = .txt mime = text/plain words = 4718 sentences = 231 flesch = 48 summary = Given the rapidly growing number of cases, a detailed report of clinical characteristics recognized in EVALI cases with radiological findings of lung injury will not only provide a better understanding of the natural history of the disease, but also create a strong foundation for the development of evidence-based guidelines for the diagnosis, prognosis, and treatment of this condition. Here, we present data from a series of ten cases that recognize clinical characteristics in hospitalized EVALI patients with radiological findings of lung injury. Our ten-case series data recognized that clinical characteristics in hospitalized EVALI patients with radiological findings of lung injury, may include both respiratory and gastrointestinal or constitutional symptoms and based on the current literature may be misdiagnosed. E-cigarette or vaping product-use-associated lung injury (EVALI): A case report of a pneumonia mimic with severe leukocytosis and weight loss cache = ./cache/cord-257336-rpx71ww5.txt txt = ./txt/cord-257336-rpx71ww5.txt === reduce.pl bib === id = cord-257433-qgkwylmk author = Candeloro, Elisa title = An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era date = 2020-10-15 pages = extension = .txt mime = text/plain words = 3560 sentences = 170 flesch = 58 summary = We collected the data on the patients that were referred to our hospital from March 9 to April 19 2020 either for ischemic or hemorrhagic stroke or for intracerebral cerebral hemorrhage (ICH), i.e., a timeframe of 42 days following the promulgation of the decree of the Lombardy Governor for the institution of the hub-and-spoke system. For each patient we acknowledged how he/she had reached the hospital (without or with the regional emergency transportation system AREU), the individual risk factors, the kind of stroke according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification (4), the location of the stroke according to Oxfordshire Classification (OCSP) (5), the therapeutic procedures (IVT, EVT, CEA), and a justification in case no procedure was undertaken, the NIH Stroke Scale (NIHSS) score before and after the procedure. cache = ./cache/cord-257433-qgkwylmk.txt txt = ./txt/cord-257433-qgkwylmk.txt === reduce.pl bib === === reduce.pl bib === id = cord-257309-sazs5wgh author = Ho, Hsi-en title = Clinical Outcomes and Features of Covid-19 in Patients with Primary Immunodeficiencies in New York City date = 2020-10-08 pages = extension = .txt mime = text/plain words = 1341 sentences = 87 flesch = 49 summary = title: Clinical Outcomes and Features of Covid-19 in Patients with Primary Immunodeficiencies in New York City Main Text: Coronavirus disease 2019 (Covid-19) remains an ongoing pandemic, and data on the clinical impact of SARS-CoV-2 infection in patients with primary immunodeficiency diseases (PIDs) are limited (1) (2) (3) . Here, we report the clinical features and outcomes of Covid-19 in patients from a large PID center in New York City during this period. Twelve out of 16 patients required hospitalization, 5 of which involved intensive care unit In all, 4/16 individuals died (CVID, n=2; hypogammaglobulinemia, n=1; IgA-IgG2 deficiency, n=1) and 12/16 individuals recovered from COVID-19. Lymphopenia in Covid-19 has been associated with disease severity in patients without PIDs (5) . This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) by the American Academy of Allergy, Asthma and Immunology (AAAAI). cache = ./cache/cord-257309-sazs5wgh.txt txt = ./txt/cord-257309-sazs5wgh.txt === reduce.pl bib === === reduce.pl bib === id = cord-258117-5gpo8smn author = Le Naour, Julie title = Trial watch: IDO inhibitors in cancer therapy date = 2020-06-14 pages = extension = .txt mime = text/plain words = 8522 sentences = 471 flesch = 34 summary = 10, 58, 59 In this setting, preclinical studies have revealed an interesting paradox: while IDO inhibitors have a negligible effect on established tumors as single-agent, combination of IDO inhibitors and immunotherapies including checkpoint blockers targeting cytotoxic T lymphocyte-associated protein 4 (CTLA4) or PD-1 yields a synergistic effect to control cancer burden and favor survival. 142 These disappointing results suggested that this combinatorial therapy did not improve the clinical outcome of melanoma patients receiving pembrolizumab, confirming that the role of epacadostat (or IDO1 inhibitors in general) in advanced solid tumors with robust PD-1 signaling remains unclear. [210] [211] [212] Along similar lines, the Phase III study NCT03661320 compared the efficacy, tolerability and safety of three therapeutic regimens for MIBC: neoadjuvant standard of care chemotherapy with cisplatin [213] [214] [215] [216] [217] and gemcitabine, 218,219 (NAC) versus NAC combined with nivolumab or nivolumab plus BMS-986205, followed by continuation of adjuvant immunotherapy (nivolumab with or without the IDO1 inhibitor) post radical cystectomy. cache = ./cache/cord-258117-5gpo8smn.txt txt = ./txt/cord-258117-5gpo8smn.txt === reduce.pl bib === id = cord-258727-mhg56j20 author = Kolar, Dusan title = Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic date = 2020-08-08 pages = extension = .txt mime = text/plain words = 428 sentences = 23 flesch = 49 summary = It is also worth noting that most of the patients with severe and refractory mood disorders and comorbid anxiety disorders followed in the mood disorders specialized clinic remained stable and well served remotely via telemedicine instead of in-person visits over the last 3-4 months of COVID-19 pandemic. Patients are well supported by their family members who stay at home during the COVID-19 lockdown and this experience of togetherness obviously was beneficial for patients with mood disorders. Finally, many people are working from home during the COVID-19 pandemic. Working from home is beneficial for some patients with mood and anxiety disorders as they are not exposed to social stress at their work place. Psychiatric emergency department volume during Covid-19 pandemic COVID-19 pandemic: impact on psychiatric care in the United States Psychiatrist experience of remote consultations by telephone in an outpatient psychiatric department during the COVID-19 pandemic cache = ./cache/cord-258727-mhg56j20.txt txt = ./txt/cord-258727-mhg56j20.txt === reduce.pl bib === id = cord-258708-da6x5rxa author = Hafiane, Anouar title = SARS-CoV-2 and the cardiovascular system date = 2020-07-16 pages = extension = .txt mime = text/plain words = 4033 sentences = 253 flesch = 43 summary = The coronavirus disease COVID-19 is a public health emergency caused by a novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In COVID-19, particular attention has been given to the role of angiotensin-(Ang) converting enzyme 2 (ACE2), and the binding site for SARS-CoV-2 cellular entry (3). One of the clinical features of patients infected with SARS-CoV-2 included abnormal features such as acute cardiac injury (12%) (22) . Significance of the SARS-CoV-2 infection in the CV system is reflected through incidences of acute myocardial injury, arrhythmias, ACS, sepsis, septic shock, viral myocarditis, and heart failure. Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection 19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection cache = ./cache/cord-258708-da6x5rxa.txt txt = ./txt/cord-258708-da6x5rxa.txt === reduce.pl bib === id = cord-258583-5qdthy0j author = Yan, He title = Multiple organ injury on admission predicts in‐hospital mortality in patients with COVID‐19 date = 2020-09-30 pages = extension = .txt mime = text/plain words = 2580 sentences = 154 flesch = 48 summary = We aimed to explore the association between OI and mortality according to the number of affected organs (heart, liver, and kidney) in patients with COVID-19. The primary findings of this investigation were the following: Clinical studies suggested SARS-CoV-2 infection was associated with heart, kidney, and liver injury, which could serve as possible risk factors for increased disease severity. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Clinical characteristics of non-ICU hospitalized patients with coronavirus disease 2019 and liver injury: a retrospective study A comparative study of clinical presentation and risk factors for adverse outcome in patients hospitalised with acute respiratory disease due to MERS coronavirus or other causes Association of reninangiotensin system inhibitors with severity or risk of death in patients with hypertension hospitalized for coronavirus disease 2019 (COVID-19) infection in Wuhan, China Multiple organ injury on admission predicts in-hospital mortality in patients with COVID-19 cache = ./cache/cord-258583-5qdthy0j.txt txt = ./txt/cord-258583-5qdthy0j.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-258888-amimzjee author = Ananth, Lakshmi title = Management of ENT Surgical Emergencies Amidst COVID-19 Lockdown: Our Experience in a Tertiary Referral Hospital date = 2020-07-23 pages = extension = .txt mime = text/plain words = 3667 sentences = 187 flesch = 48 summary = Appropriate protocols for screening, triage and management of non-COVID patients with due precautions and infection control strategies can ensure that emergencies get timely and appropriate attention while preventing spread of infection among patients and healthcare workers. In this article, we describe our experience with the triage and management of ENT & Lakshmi Ananth lakshmiananth@yahoo.com emergencies at a tertiary referral hospital in the setting of a lockdown with limited resources and the protocol followed by us to maximize the safety of health care personnel involved and avoiding the possibility of hospital transmission of infection. In the absence of testing facility, the above suggested protocol will be helpful while performing surgeries even after the lockdown period ends in order to minimize the risk of hospital transmission of infection and increase the safety of patients and healthcare workers. cache = ./cache/cord-258888-amimzjee.txt txt = ./txt/cord-258888-amimzjee.txt === reduce.pl bib === === reduce.pl bib === id = cord-258758-sz8chn5e author = Resch, Tim title = Atypical COVID -19 presentation in patient undergoing staged TAAA repair date = 2020-05-16 pages = extension = .txt mime = text/plain words = 1294 sentences = 77 flesch = 56 summary = title: Atypical COVID -19 presentation in patient undergoing staged TAAA repair Patient was tested positive for Covid 19 virus and later during hospitalization developed more typical fever and respiratory symptoms that were managed medically. The 2 typical presenting symptoms in the majority of patients range from common upper respiratory 3 tract signs such as cough, sore throat and fever to more severe shortness of breath and severe 4 respiratory dysfunction. 9 We present a case of COVID 19 infection with atypical debut in a patient having undergone 10 staged, endovascular thoraco-abdominal repair 2 weeks previously. 14 The patient underwent stage 1, percutaneous thoracic endovascular repair (TEVAR) with 15 placement of a thoracic stent-graft from the left subclavian artery to 4 cm proximal to the celiac 16 artery origin (Fig 3) . Short-term outcome of spinal cord ischemia after endovascular repair of thoracoabdominal aortic 3 aneurysms Staged endovascular repair of thoracoabdominal 9 aortic aneurysms limits incidence and severity of spinal cord ischemia cache = ./cache/cord-258758-sz8chn5e.txt txt = ./txt/cord-258758-sz8chn5e.txt === reduce.pl bib === id = cord-258402-9s57thvn author = Dabas, Vineet title = Management of Orthopaedic Accidental Emergencies Amidst COVID-19 Pandemic: Our Experience in Preparing to Live with Corona date = 2020-09-10 pages = extension = .txt mime = text/plain words = 3703 sentences = 193 flesch = 51 summary = INTRODUCTION: With increasing prevalence of coronavirus cases (including among health care providers), the current advice for orthopaedic surgeons is to favor non-operative management of most injuries and reduce face-to-face follow-up. The standard operating procedures (SOPs) were implemented which were based upon the recommendations of ICMR, Ministry of Health and Family Welfare, GOI and Indian Orthopaedic Association (IOA) [10] , and targeted to provide optimum healthcare at a minimum risk to the treating team as well as other patients admitted to the hospital. Among the non-COVID-19 suspects, who were shifted to non-isolation zone, those who could be managed conservatively were given adequate primary treatment like fluids, analgesics and splintage and were discharged at the earliest so as to minimize the risk of infection transmission to them as well as health care workers. cache = ./cache/cord-258402-9s57thvn.txt txt = ./txt/cord-258402-9s57thvn.txt === reduce.pl bib === id = cord-258315-yt1ytasw author = Kato, Hideaki title = Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship date = 2020-05-13 pages = extension = .txt mime = text/plain words = 1776 sentences = 111 flesch = 54 summary = title: Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship Abstract We investigated the clinical course of individuals with 2019 novel coronavirus disease (COVID-19) who were transferred from the Diamond Princess cruise ship to 12 local hospitals. In this study, we describe the clinical conditions, treatment, and the clinical course of the patients positive for SARS-CoV-2 who were transferred from the Diamond Princess cruise ship for further medical care to the participating hospitals in this study. The patients' vital signs, laboratory data, chest radiographs, or computed tomography (CT) findings at the time of admission and treatment, and the data on the clinical course and prognosis were collected using case report forms. Notably, the severity of this disease in the patients transferred from the cruise ship was very high compared with that previously reported in the general population in China [5, 6] . cache = ./cache/cord-258315-yt1ytasw.txt txt = ./txt/cord-258315-yt1ytasw.txt === reduce.pl bib === id = cord-259801-xuvcrvo2 author = Koch, Christian A. title = The Various Faces of Hyperthyroidism date = 2020-06-05 pages = extension = .txt mime = text/plain words = 2063 sentences = 109 flesch = 37 summary = It starts out with an important article by Hoermann and colleagues underscoring the biochemically heterogeneous expression of thyroid hormone activities in subclinical/overt hyperthyroidism and exogenous thyrotoxicosis (1) . In their study of 461 patients composed of untreated thyroid autonomy, Graves' disease, and levothyroxine TSH suppressive therapy after thyroidectomy for thyroid carcinoma, they demonstrate that deiodinase activity is markedly reduced in patients with exogenous thyrotoxicosis compared to patients with endogenous hyperthyroidism because of a lack of TSH stimulation, inhibition by levothyroxine, and the absence of a functioning thyroid gland. Cipolla and colleagues share their experience performing total thyroidectomy on 594 patients with Graves' disease between age 32 y and 56 y underscoring that it is a safe and effective treatment in experienced hands (15) . Zhou and colleagues underscore the important role of neural monitoring during thyroid surgery for Graves' disease in their retrospective series including 55 thyroidectomies and 82 procedures with intermittent intraoperative neuromonitoring (IONM) and 72 procedures with continuous IONM (19) . cache = ./cache/cord-259801-xuvcrvo2.txt txt = ./txt/cord-259801-xuvcrvo2.txt === reduce.pl bib === id = cord-259229-e8m8m4ut author = Samidurai, Arun title = Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic Strategies date = 2020-09-16 pages = extension = .txt mime = text/plain words = 10768 sentences = 530 flesch = 38 summary = Emerging evidence reveals a direct interplay between COVID-19 and dire cardiovascular complications, including myocardial injury, heart failure, heart attack, myocarditis, arrhythmias as well as blood clots, which are accompanied with elevated risk and adverse outcome among infected patients, even sudden death. Respiratory illness and acute cardiac injury are major clinical manifestations observed in patients infected with SARS-CoV-2 during the late stage complications of the disease [38] . Based on the available clinical data, potential myocardial injury is a relevant challenge among hospitalized patients with COVID-19 with increased risk of mortality; therefore, it is essential for multidisciplinary assessment, including blood pressure control in hypertensive patients as well as cardiovascular evaluation and therapy to reduce the morality for COVID-19 infection. Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients with Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China cache = ./cache/cord-259229-e8m8m4ut.txt txt = ./txt/cord-259229-e8m8m4ut.txt === reduce.pl bib === id = cord-258133-zsweppku author = Fischer, M. title = COVID-19 paranoia in a patient suffering from schizophrenic psychosis – a case report date = 2020-04-17 pages = extension = .txt mime = text/plain words = 1125 sentences = 59 flesch = 48 summary = Here we report the case of a patient with schizophrenia presenting with COVD-19related delusions and hallucinations, illustrating the potential of COVID-19 to precipitate entry into a psychotic phase and impact symptom manifestation. This case report shows the impact of the COVID-19 crisis on the psychopathology of a patient with paranoid psychosis leading to the outbreak of a psychotic phase with paranoid-hallucinatoric experiencing and unrealistic expectations and concerns. This observation may be in line with the previous reports that higher levels of concurrent anxiety in patients with schizophrenia correlated with lower perception of personal risk of infection with swine flu, although the reason for this effect is unclear (Maguire et al., 2019a) . Overall, the current case report illustrates the potential for the psychological context of the COVID-19 emergency to influence emergence and manifestations of symptoms of psychosis, and indicates that measured, balanced and responsible reporting of the COVID-19 crisis in the media will be important to minimize the risk of overreactions in at risk persons and to avoid entry into psychotic episodes. cache = ./cache/cord-258133-zsweppku.txt txt = ./txt/cord-258133-zsweppku.txt === reduce.pl bib === id = cord-258128-qtmjgrml author = Mirjalili, Mahtabalsadat title = Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen date = 2020-07-03 pages = extension = .txt mime = text/plain words = 6450 sentences = 369 flesch = 38 summary = 12 In one case report regarding the successful treatment of a kidney transplant recipient with pneumonia caused by SARS-CoV-2 in China, all the immunosuppressants were stopped and the patient received 5 g intravenous immunoglobulin (IVIG) on the first day and then 10 g/day for the next 11 days, with 40 mg/day methylprednisolone for 12 days and 5 million units/day interferon as atomization inhalation. 17, 18 Considering that adverse clinical outcomes and increased mortality and morbidity following the administration of corticosteroids in patients with respiratory infections caused by respiratory syncytial virus (RSV), influenza, SARS-CoV-1, or MERS-CoV may be due to an increased risk of secondary bacterial infections, their use for the prevention of disease progression or its treatment remains under discussion. So far, few studies have been conducted regarding the use of this drug in liver and kidney transplant patients, but if it is administered to this population, its adverse effects and interactions with immunosuppressants and other medications used in transplant patients, such as fluoroquinolones for the treatment of Gram-negative infections, should be considered. cache = ./cache/cord-258128-qtmjgrml.txt txt = ./txt/cord-258128-qtmjgrml.txt === reduce.pl bib === id = cord-259448-deya8dwn author = Li, Caixia title = Differential microRNA expression in the peripheral blood from human patients with COVID‐19 date = 2020-09-22 pages = extension = .txt mime = text/plain words = 2648 sentences = 172 flesch = 56 summary = The expression levels of various miRNAs were detected by high‐throughput sequencing, and correlation analysis was performed on the target genes that are primed by miRNAs. KEY FINDINGS: Compared with the healthy controls, 35 miRNAs were upregulated and 38 miRNAs were downregulated in the human patients with COVID‐19. 16 In this study, to better understand the miRNA expression pattern in peripheral blood collected from human COVID-19 patients and healthy donors, high-throughput sequencing, and bioinformatics analysis were employed. The differential miRNA expression found in COVID-19 patients may regulate the immune responses and viral replication during viral infection. As shown in Figure 3 , there were significant differences in the miRNA expression between the COVID-19 patients and the control group. In the present study, the differential miRNA expression in peripheral blood from COVID-19 patients and healthy donors was observed. cache = ./cache/cord-259448-deya8dwn.txt txt = ./txt/cord-259448-deya8dwn.txt === reduce.pl bib === id = cord-259699-48jg7ci7 author = González-Calatayud, Dra Mariel title = Observational study of the suspected or confirmed cases of sars COV-2 infection needing emergency surgical intervention during the first months of the pandemic in a third level hospital: Case series date = 2020-10-24 pages = extension = .txt mime = text/plain words = 2797 sentences = 131 flesch = 46 summary = METHOD: We conducted an observational study of patients undergoing surgical intervention in the operating room assigned as COVID, where we considered age, sex, treating department, type of intervention, and initial biomarkers (first five days of hospitalization), days of hospital stay, days in the Intensive Care Unit and reason for discharge. We conducted an observational study of patients undergoing surgical intervention in the operating room assigned as COVID, where we considered age, sex, treating department, type of intervention, and initial laboratory tests (first five days of hospitalization): ferritin, D-dimer, total leucocyte count, total lymphocyte count, lymphocytes (%), platelets, lactate dehydrogenase, fibrinogen, and procalcitonin; we also considered days of hospital stay (DOHS), days in the Intensive Care Unit (ICU), and reason for discharge. Indeed, it has been decided to reduce elective surgical treatment, we have also observed that patients undergoing emergency surgery with suspicion or confirmation of SARS-Cov-2 infection have significant mortality depending on the performed surgical procedure, without relevant findings regarding biomarkers. cache = ./cache/cord-259699-48jg7ci7.txt txt = ./txt/cord-259699-48jg7ci7.txt === reduce.pl bib === id = cord-258930-60yn4hg7 author = D’Amico, Ferdinando title = Inflammatory bowel diseases and COVID-19: the invisible enemy date = 2020-04-16 pages = extension = .txt mime = text/plain words = 1027 sentences = 65 flesch = 47 summary = All biological and immunosuppressive treatments were discontinued, visits in person were replaced by online consultations, and 318 patients were daily recommended to wash their hands frequently, to reduce the time spent outside the home and to use masks outside the home 7 . It is important to underline that a relevant percentage of evaluated patients had risk factors of infection: chronic diseases (15.4%), immunosuppressive agent therapy (11.0%), elderly (10.4%), high-risk professional categories (7.5%), and biological therapy (6.3%) 7 . Telemedicine has also been associated with a reduction in gastroenterological consultations and hospitalizations and could be a valid alternative to improve the quality of IBD patient care during the COVID-19 outbreak 23 . Comparative Risk of Serious Infections With Biologic and/or Immunosuppressive Therapy in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis Protection of 318 inflammatory bowel disease patients from the outbreak and rapid spread of COVID-19 infection in Wuhan cache = ./cache/cord-258930-60yn4hg7.txt txt = ./txt/cord-258930-60yn4hg7.txt === reduce.pl bib === id = cord-258916-jbdz1pk0 author = Andreae, MH title = Data and Debriefing Observations on Healthcare Simulation to Prepare for the COVID-19 Pandemic: Healthcare Simulation for COVID-19 date = 2020-07-15 pages = extension = .txt mime = text/plain words = 2882 sentences = 161 flesch = 40 summary = We report on data and debriefing observations in the context of an immersive simulation conducted to (a) train clinicians and (b) test new protocols and kits, developed in table-top exercises without prior clinical experience to fit anticipated clinical encounters in the setting of the rapidly expanding COVID-19 pandemic. We simulated scenarios with particular relevance for anesthesiology, perioperative and critical care, including (1) cardiac arrest, (2) emergency airway management, (3) tele-instruction for remote guidance and supervision, and (4) transporting an intubated patient. • Immersive healthcare simulation employing anticipated clinical encounters may be useful to test COVID-19 [8, 10, 11] and other airborne contagious disease hospital protocols, developed with limited clinical experience, to detect shortcoming before such gaps become apparent in clinical care and threaten patient or provider safety. cache = ./cache/cord-258916-jbdz1pk0.txt txt = ./txt/cord-258916-jbdz1pk0.txt === reduce.pl bib === id = cord-258498-0mvxwo3w author = Shah, Saleha title = COVID-19 and paediatric dentistry- traversing the challenges. A narrative review date = 2020-08-21 pages = extension = .txt mime = text/plain words = 13560 sentences = 748 flesch = 49 summary = This review article informs about measures which reduce facility risk, manage symptomatic patients and protect personal health care and management with reference to paediatric dentistry. 5, 6, 7 The risk of SARS-CoV-2 transmission via aerosols generated during dental procedures cannot be eliminated when practicing in the absence of Airborne Precautions (airborne infection isolation rooms or single-patient rooms, respiratory protection program, N95 respirators). 47 Primary prevention encompasses prenatal health care, avoidance of night time bottle feed with sugary drinks or milk, restricting sugar intake and frequency for children younger than 24 months, avoiding frequent/nocturnal breast or bottle feeding after 1 year, exposure to dietary fluoridate (water, milk, salt), use of an age appropriate amount of fluoride toothpaste containing at least 1000ppm fluoride for brushing at least twice a day, dental visit in the first year of life and regular applications of 5% fluoride. cache = ./cache/cord-258498-0mvxwo3w.txt txt = ./txt/cord-258498-0mvxwo3w.txt === reduce.pl bib === id = cord-259204-27t269pd author = Grimaldi, D. title = Characteristics and outcomes of Acute Respiratory Distress Syndrome related to COVID-19 in Belgian and French Intensive Care Units according to antiviral strategies. The COVADIS multicenter observational study. date = 2020-07-07 pages = extension = .txt mime = text/plain words = 3871 sentences = 223 flesch = 50 summary = Background Limited data are available for antiviral therapy efficacy especially for the most severe patients under mechanical ventilation suffering from Covid-19 related Acute Respiratory Distress Syndrome (ARDS). Methods Observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, comparing antiviral strategies (none, hydroxychloroquine (HCQ), lopinavir/ritonavir (L/R), others (combination or remdesivir). Limited data are available for antiviral therapy efficacy especially for the most severe patients under mechanical ventilation suffering from Covid-19 related Acute Respiratory Distress Syndrome (ARDS). Observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, comparing antiviral strategies (none, hydroxychloroquine (HCQ), lopinavir/ritonavir (L/R), others (combination or remdesivir). In moderate to severe ARDS COVID-19 patients, we did not observe an association between treatment with hydroxychloroquine or lopinavir/ritonavir and ventilatory free days as compared to no antiviral treatment. cache = ./cache/cord-259204-27t269pd.txt txt = ./txt/cord-259204-27t269pd.txt === reduce.pl bib === === reduce.pl bib === id = cord-259984-csdf1a69 author = Raffiq, Azman title = COVID-19 Pandemic and Its Impact on Neurosurgery Practice in Malaysia: Academic Insights, Clinical Experience and Protocols from March till August 2020 date = 2020-10-27 pages = extension = .txt mime = text/plain words = 16400 sentences = 871 flesch = 47 summary = For emergent/unavoidable case for a known or undetermined COVID-19 patient, the surgeon and all OT personnel in the surgical suite should use PAPR, which filter the air being breathed in addition to face shields and other standard PPE. In routine clinical care of COVID-19 suspected or confirmed infections, surgical masks are acceptable PPE, except in the case of aerosol generating procedures (intubation, high flow nasal cannula, non-invasive ventilation, bronchoscopy, administration of nebulised medications, etc). Hospitals, professional societies and ministries of health could also provide physician and nursing staff with basic ICU and ventilator management refresher education to improve their capacity to care for COVID-19 patients. Designated COVID-19 hospitals may not be able to support all elective cases, in particular those that require post-operative intensive care or significant use of blood and blood products Surgeons, in consultation with anaesthetist, nursing colleagues as well as patients (or legally accepted next of kin), should weigh the risks of proceeding (exposure, lack of resources) against those of deferment, (progression of disease, worse patients outcomes) including the expectation of delay of 2-3 months or more or until the COVID-19 is less prevalent Figure 6 . cache = ./cache/cord-259984-csdf1a69.txt txt = ./txt/cord-259984-csdf1a69.txt === reduce.pl bib === === reduce.pl bib === id = cord-260456-kjmab3og author = Hegde, Shruti title = Massive Pulmonary Embolism Complicating Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report date = 2020-10-28 pages = extension = .txt mime = text/plain words = 1856 sentences = 127 flesch = 51 summary = title: Massive Pulmonary Embolism Complicating Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report On bedside TTE, there was evidence of right heart strain and elevated pulmonary artery systolic pressure of 45 mmHg. All data was indicative of a massive APE as the etiology for his hemodynamic collapse. Furthermore, timely diagnosis can be made to aid in appropriate management with the help of bedside TTE and ECG in cases where CTPA is not feasible secondary to the patient's hemodynamic instability. (1) Patients with severe coronavirus disease 2019 (COVID-19) pneumonia are hypercoagulable and are at risk for acute pulmonary embolism (APE). (2) Massive acute pulmonary embolism should always be considered in the differential diagnosis for sudden and rapid hemodynamic decline in patients with COVID-19. (3) Critical care bedside echocardiography along with other clinical indicators helps in timely diagnosis and thus treatment of APE in patients with COVID-19 pneumonia, which is lifesaving. cache = ./cache/cord-260456-kjmab3og.txt txt = ./txt/cord-260456-kjmab3og.txt === reduce.pl bib === id = cord-260503-yq4dtf8n author = SAMARANAYAKE, LAKSHMAN P. title = Severe acute respiratory syndrome and dentistry A retrospective view date = 2004-09-30 pages = extension = .txt mime = text/plain words = 6836 sentences = 383 flesch = 54 summary = Objectives The authors trace the emergence of the SARS outbreak from southern China and its spread worldwide, discuss the viral etiology of the infection and its clinical features, and review the infection control guidelines issued during the outbreak by the health authorities in Hong Kong, the Centers for Disease Control and Prevention, the World Health Organization and the American Dental Association. Conclusions and Clinical Implications Researchers believe that a combination of factors, including the universal infection control measures that the dental community has implemented and/or the low degree of viral shedding in the prodromal phase of SARS, may have obviated the spread of the disease in dental settings. Interim domestic infection control precautions for aerosol-generating procedures on C L I N I C A L P R A C T I C E patients with severe acute respiratory syndrome (SARS) cache = ./cache/cord-260503-yq4dtf8n.txt txt = ./txt/cord-260503-yq4dtf8n.txt === reduce.pl bib === id = cord-259969-q65k590s author = Kösters, Katrin title = Cutaneous Vasculitis in a Patient With COVID-19 date = 2020-10-05 pages = extension = .txt mime = text/plain words = 824 sentences = 59 flesch = 43 summary = We describe a 43-year-old patient with coronavirus disease 2019 who developed a bullous hemorrhagic rash that progressed to necrotic lesions. Small blood vessel occlusion by microthrombi, which has been described in patients with coronavirus disease 2019 (COVID-19) [1] , could not be demonstrated. Under suspicion of a SARS-CoV-2-induced cutaneous vasculitis, the patient was treated with prednisolone at 0.5 mg per kilogram. Variable and heterogenous skin manifestations in patients with COVID-19 have been described that appear before, during, and after the disease [2] . However, other groups have described skin manifestations in up to 20% of COVID patients [4, 5] . However, our case demonstrates a small/medium-sized vessel vasculitis with involvement of mucous membranes as the cause of skin manifestations in a patient with COVID-19 that appeared late in the disease. Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging issue cache = ./cache/cord-259969-q65k590s.txt txt = ./txt/cord-259969-q65k590s.txt === reduce.pl bib === id = cord-259747-sl9q63oc author = Remmelink, Myriam title = Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients date = 2020-08-12 pages = extension = .txt mime = text/plain words = 4541 sentences = 244 flesch = 48 summary = BACKGROUND: Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients. IHC revealed positive cells with a heterogeneous distribution in the lungs of 11 of the 17 (65%) patients; RT-PCR yielded a wide distribution of SARS-CoV-2 in different tissues, with 8 patients showing viral presence in all tested organs (i.e., lung, heart, spleen, liver, colon, kidney, and brain). In this post-mortem study, we included the first 17 adult patients (> 18 years) who died in our hospital (either in a COVID-19 unit or an intensive care unit) from March 13, 2020, with confirmed SARS-CoV-2 infection (i.e., positive RT-PCR assay on nasopharyngeal swab and/or bronchoalveolar lavage specimen). This post-mortem study showed several histopathological abnormalities in COVID-19 non-survivors; however, none of the findings was specific for direct viral injury, even though SARS-CoV-2 was detected in all examined organs using RT-PCR. cache = ./cache/cord-259747-sl9q63oc.txt txt = ./txt/cord-259747-sl9q63oc.txt === reduce.pl bib === id = cord-259073-dixskemz author = Ward, Christine F. title = Altered Mental Status as a Novel Initial Clinical Presentation for COVID-19 Infection in the Elderly date = 2020-05-15 pages = extension = .txt mime = text/plain words = 2126 sentences = 124 flesch = 47 summary = The elderly are the most vulnerable to significant adverse complications from COVID 19 and AMS should be considered as a possible sign of infection to initiate treatment early in the course of the disease, perhaps before respiratory symptoms are apparent. In this report, we present four patients diagnosed with COVID-19 who initially presented with altered mental status without fever or cough or respiratory distress. Each of the four patients developed AMS without fever or respiratory symptoms and were transferred to the local emergency department and were tested for the COVID-19 virus as part of their medical work up. Recognizing the COVID-19 infection early is especially important in the frail elderly, particularly for individuals in communal living facilities where isolating these patients can help limit the spread of the virus, There is evidence from previous viral epidemics of associated neuropsychiatric symptoms. cache = ./cache/cord-259073-dixskemz.txt txt = ./txt/cord-259073-dixskemz.txt === reduce.pl bib === id = cord-259907-yqmi0cqy author = Maxwell, Cynthia title = Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) No. 225, April 2009 date = 2009-10-31 pages = extension = .txt mime = text/plain words = 3419 sentences = 211 flesch = 49 summary = title: Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) No. 225, April 2009 Labour triage and antenatal hospital admission Actions • Assessment is made as to whether the patient has suspected or probable SARS [1, 14] • Upon arrival in the labour and delivery triage unit, pregnant patients presenting with fever N38°C and respiratory symptoms and one of the associated symptoms (cough, unexplained hypoxia, shortness of breath, or dyspnea) and history of an exposure to an individual with probable SARS are immediately transferred to the designated isolation room, which is equipped with negative pressure ventilation. • Parents and family are counselled to look for symptoms and signs of SARS in the mother and newborn, especially in the first 10 days following delivery, and to report to any findings to the health care team Summary SARS, a life-threatening respiratory illness caused by a novel coronavirus, was responsible for a worldwide outbreak in 2003. cache = ./cache/cord-259907-yqmi0cqy.txt txt = ./txt/cord-259907-yqmi0cqy.txt === reduce.pl bib === id = cord-260525-bohv78hi author = Mei, Yang title = Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza date = 2020-07-31 pages = extension = .txt mime = text/plain words = 4168 sentences = 228 flesch = 47 summary = We compiled laboratory results from the first 14 days of the hospitalized patients using parameters that are most significantly different between COVID-19 and influenza and hierarchically clustered COVID-19 patients. Patients in the highest risk cluster had leukocytosis including neutrophilia and monocytosis, severe anemia, increased red blood cell distribution width, higher BUN, creatinine, D-dimer, alkaline phosphatase, bilirubin, and troponin. Overall, our study reveals significant differences in the laboratory parameters between the hospitalized COVID-19 and influenza patients. Compared to influenza patients, the most significant differences over the course of 14 days of hospitalization in COVID-19 patients were worsening anemia, worsening leukocytosis, and an increase in D-dimer, BUN, and ALT. Instead of comparing clinical endpoints to evaluate risks as performed in most of the published studies, we stratified the hospitalized COVID-19 patients through clustering of their laboratory results that were most significantly different from influenza patients (i.e. complete blood count, D-dimer, BUN, and ALT) during the first 14 days of hospitalization. cache = ./cache/cord-260525-bohv78hi.txt txt = ./txt/cord-260525-bohv78hi.txt === reduce.pl bib === id = cord-260215-gsnjlhjd author = Dhanani, Jayesh title = Fundamentals of aerosol therapy in critical care date = 2016-10-07 pages = extension = .txt mime = text/plain words = 8319 sentences = 485 flesch = 36 summary = Given that respiratory diseases are the commonest causes of critical illness, use of aerosol therapy to provide high local drug concentrations with minimal systemic side effects makes this route an attractive option. The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). NIV non-invasive ventilation, HME heat and moisture exchanger, pMDI pressurized metered dose inhaler, AAD adaptive aerosol device, VMN vibrating mesh nebulizer, DPI dry powder inhaler, PEEP positive end-expiratory pressure Fig. 3 Effects of regional lung aeration and pneumonia on drug concentration in lungs. The patient position, formulation, temperature, endotracheal tube size, presence of airway obstruction or ventilatory asynchrony, flow pattern, respiratory rate, dose and frequency applied or position of the nebulizer in the circuit are important factors that influence delivery to the lung. cache = ./cache/cord-260215-gsnjlhjd.txt txt = ./txt/cord-260215-gsnjlhjd.txt === reduce.pl bib === id = cord-259585-mjtxiu0t author = Occhipinti, Vincenzo title = Challenges in the Care of IBD Patients During the CoViD-19 Pandemic: Report From a “Red Zone” Area in Northern Italy date = 2020-04-21 pages = extension = .txt mime = text/plain words = 2803 sentences = 122 flesch = 46 summary = Every possible effort was made to quickly increase the capacity of intensive care units (ICUs) to accommodate the alarming numbers of very sick CoViD-19 patients, including constructing new units in unused areas of the hospital or converting surgical rooms into ICUs. These drastic measures were implemented in a very short period of time, and although necessary to counteract the devastation brought about by the outbreak, they also posed tremendous challenges to the care of patients with GI conditions, including those with inflammatory bowel diseases (IBD). However, for patients on biologic therapies, we have implemented a mandatory phone call-in the day before any planned hospital visit to screen for possible CoViD-19 symptoms or contact with infected individuals and to reassure patients that all possible precautions are being taken by the IBD center to reduce the risk of infection. cache = ./cache/cord-259585-mjtxiu0t.txt txt = ./txt/cord-259585-mjtxiu0t.txt === reduce.pl bib === id = cord-259329-8pta6o6a author = Haimovich, Adrian title = Development and validation of the quick COVID-19 severity index (qCSI): a prognostic tool for early clinical decompensation date = 2020-07-21 pages = extension = .txt mime = text/plain words = 4823 sentences = 275 flesch = 44 summary = The objective of this study was to derive a risk stratification tool to predict 24 hour respiratory decompensation in admitted patients with COVID-19. 12 Second, to aid healthcare providers in assessing illness severity in COVID-3 19 patients, we present predictive models of early respiratory failure during hospitalization and compare them to three benchmarks accessible using data in the electronic health record: the Elixhauser comorbidity index, 13 the quick sequential organ failure assessment (qSOFA), 14, 15 and the CURB-65 pneumonia severity score. This was a retrospective observational cohort study to develop a prognostic model of early respiratory decompensation in patients admitted from the emergency department with COVID-19. 1Consistent with clinical observations, we noted a significant rate of progression to critical respiratory illness within the first 24 hours of hospitalization in COVID-19 patients. cache = ./cache/cord-259329-8pta6o6a.txt txt = ./txt/cord-259329-8pta6o6a.txt === reduce.pl bib === === reduce.pl bib === id = cord-260083-c1r9zn43 author = Lucatelli, Pierleone title = Heparin-Related Major Bleeding in Covid-19-Positive Patient: Perspective from the Outbreak date = 2020-05-28 pages = extension = .txt mime = text/plain words = 524 sentences = 38 flesch = 40 summary = • Bleeding patients usually require blood transfusion which is in short supply during the Covid pandemic due to the lockdown and fear of entering medical facilities • Biocontainment transfer of Covid-19-positive patients within the hospital is complex and not easy to achieve [5] In view of these considerations, interventional radiology plays a crucial role and a dedicated treatment pathway should be set up. In conclusion, although major bleeding seems to be rare in Covid-19 patients, its management is complex for several reasons: the need to continue anticoagulation, shortage of blood products, multiple sites of haemorrhage and logistic issues. Ethical Approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. cache = ./cache/cord-260083-c1r9zn43.txt txt = ./txt/cord-260083-c1r9zn43.txt === reduce.pl bib === id = cord-260180-kojb8efv author = Elsoukkary, Sarah S. title = Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience date = 2020-09-17 pages = extension = .txt mime = text/plain words = 4600 sentences = 269 flesch = 49 summary = METHODS: We report the clinicopathologic findings from 32 autopsy studies conducted on patients who died of COVID-19 including routine gross and microscopic examination with applicable special and immunohistochemical staining techniques. The purpose of this study is to describe clinical and pathologic findings in major organ systems of patients who died from SARS-CoV-2 infection. In this study, we described the unique and multisystem clinical and pathologic findings in 32 autopsies of patients who died from the novel coronavirus, SARS-CoV-2. On histologic examination, we observed findings secondary to the patients' preexisting conditions in the heart, lungs, liver, and kidneys, as well as changes secondary to SARS-CoV-2 infection such as various stages of DAD and multiple thromboemboli in large and small vessels in multiple organs. While the lung findings are most significant for the majority of those infected, other organ systems are frequently involved including with widespread microscopic thromboses in numerous organs, as well as liver, kidney, and lymph node pathology. cache = ./cache/cord-260180-kojb8efv.txt txt = ./txt/cord-260180-kojb8efv.txt === reduce.pl bib === id = cord-259411-434acu0h author = Aljehani, Faisal A. title = Inpatient Diabetes and Hyperglycemia Management Protocol in the COVID-19 Era date = 2020-07-06 pages = extension = .txt mime = text/plain words = 1461 sentences = 80 flesch = 45 summary = Here we present a flow chart (figure 1) for the management of diabetes and hyperglycemia in non-critically ill patients as an attempt to standardize a protocol that may be used across different services in the hospital without the need of a diabetes specialist. Experts have suggested that we need to revise guidelines to allow more usage of non-insulin anti-diabetic medications for hospitalized patients (14) . Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline Efficacy of basal-bolus insulin regimens in the inpatient management of non-critically ill patients with type 2 diabetes: A systematic review and meta-analysis. Debate on Insulin vs Non-insulin Use in the Hospital Setting-Is It Time to Revise the Guidelines for the Management of Inpatient Diabetes? Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery) cache = ./cache/cord-259411-434acu0h.txt txt = ./txt/cord-259411-434acu0h.txt === reduce.pl bib === id = cord-260700-u12aa739 author = Kainulainen, Leena title = Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia date = 2010-06-10 pages = extension = .txt mime = text/plain words = 3686 sentences = 248 flesch = 46 summary = title: Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia OBJECTIVE: We conducted a prospective 12-month follow-up study of respiratory tract infections in 12 adult patients with primary hypogammaglobulinemia. METHODS: Nasal swab samples and induced sputum samples were taken at the onset of acute respiratory tract infection and every 3 months thereafter. CONCLUSIONS: Despite adequate immunoglobulin replacement therapy, patients with primary hypogammaglobulinemia have increased susceptibility to respiratory tract viral infections. Using modern diagnostic techniques, we wanted to study the occurrence of respiratory tract infections, especially viral infections, in patients with primary hypogammaglobulinemia who were receiving regular immunoglobulin replacement therapy. If the spouse of the patient had acute symptoms of respiratory tract infection, she or he took nasal swabs at home according to the instructions of the research nurse and sent the vials by post. First, despite adequate immunoglobulin replacement therapy, most patients with primary hypogammaglobulinemia had increased susceptibility to respiratory tract viral infections. cache = ./cache/cord-260700-u12aa739.txt txt = ./txt/cord-260700-u12aa739.txt === reduce.pl bib === id = cord-260630-vvpzp73r author = Mandell, Lionel A. title = Etiologies of Acute Respiratory Tract Infections date = 2005-08-15 pages = extension = .txt mime = text/plain words = 2623 sentences = 120 flesch = 52 summary = In this issue of Clinical Infectious Diseases, there are 2 articles that provide us with some insight into the various etiologic agents that can cause acute respiratory tract infection (ARTI) in general practice patients in The Netherlands [1] and into the significance of the human metapneumovirus (hMPV) in patients with community-acquired pneumonia (CAP) and exacerbations of chronic obstructive pulmonary disease (COPD) in Quebec, Canada [2] . The objectives of the Dutch study were to estimate the incidence of influenza-like illnesses (ILIs) and of other ARTIs in patients visiting their general practitioners (to determine the etiologic agents) and to test the hypothesis that asymptomatic persons with subclinical infection may act as sources of transmission [1] . Nose and throat swab specimens were obtained from case patients and control subjects, and viral cultures and PCR tests were performed for detection of adenovirus, coronavirus, enterovirus, hMPV, influenza virus, parainfluenza virus, rhinovirus, and respiratory syncytial virus (RSV), as well as for Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Chlamydophila psittaci. cache = ./cache/cord-260630-vvpzp73r.txt txt = ./txt/cord-260630-vvpzp73r.txt === reduce.pl bib === id = cord-260232-98gtlad6 author = Chenna, Avantika title = Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade date = 2020-06-29 pages = extension = .txt mime = text/plain words = 4301 sentences = 247 flesch = 50 summary = title: Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade We present the case series of four patients (2 men and 2 women; 1 Caucasian and 3 African Americans; two survived and two died) with confirmed COVID-19, presenting with respiratory symptoms and acute kidney injury, who have been on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. We also discussed the role of ACE2 and the renin-angiotensin system (RAS) blockade in patients with COVID-19 infection along with pathogenesis. We presented the case series of four patients who were on angiotensin-converting enzyme inhibitors (ACE inhibitors) or angiotensin receptor blockers (ARBs) with COVID-19 infection and acute renal failure. hypothesized that the use of ACE2 modulation medications in hypertensive and diabetic patients increased the risk of developing severe COVID-19 infection [1] . cache = ./cache/cord-260232-98gtlad6.txt txt = ./txt/cord-260232-98gtlad6.txt === reduce.pl bib === === reduce.pl bib === id = cord-261062-9zhe3ejy author = Zhu, Shu-Ting title = Utility of Point-of-Care Lung Ultrasound for Clinical Classification of COVID-19 date = 2020-09-21 pages = extension = .txt mime = text/plain words = 2743 sentences = 149 flesch = 51 summary = In this study, the utility of point-of-care lung ultrasound for the clinical classification of coronavirus disease (COVID-19) was prospectively assessed. Twenty-seven adult patients with COVID-19 underwent bedside lung ultrasonography (LUS) examinations three times within the first two weeks of admission to the isolation ward. Early studies suggested that the irregular pleural line with small subpleural consolidations, white lung, confluents and irregular vertical artifacts (B-lines) are ultrasonic manifestations of COVID-19 pneumonia , and LUS scores have been used for the identification of patients with lung involvement and disease severity (Vetrugno et al. According to Spearman correlation test results (Table 2) Then, we divided the LUS scores into three scales (low ≤9; 9 35 compared with BMI < 25 kg/m 2 [14] . cache = ./cache/cord-262928-l2bqcd0l.txt txt = ./txt/cord-262928-l2bqcd0l.txt === reduce.pl bib === id = cord-262973-mydn7ver author = Zhang, Dekang title = Experts Consensus on Epidemic Prevention and Control in Radiotherapy Centers during the COVID-19 Outbreak: Experiences from Sichuan Province date = 2020-06-30 pages = extension = .txt mime = text/plain words = 2652 sentences = 149 flesch = 53 summary = In order to minimize the adverse impact of this unexpected epidemic on patients who need radiotherapy, the expert group of our radiotherapy center immediately formulated comprehensive emergency plans and prevention and control measures, partitioned the work area, launched online staff training, and optimized the radiotherapy process after the outbreak, which provided a strong guarantee for the safe and orderly operation of our radiotherapy center and kept the infection rate to an extremely low level. Patients need to perform hand hygiene disinfection and wear masks and overshoes correctly, every time they enter the radiotherapy center. To minimize the risk of cross-infection, radiotherapy centers should adjust entrances and exits to separate patient passages from medical staff passages and form a one-way channel in the internal area if possible. The level III area, such as the operator room of the accelerator, is where medical staff go after contact with patients and is classified as intermediate risk. cache = ./cache/cord-262973-mydn7ver.txt txt = ./txt/cord-262973-mydn7ver.txt === reduce.pl bib === id = cord-262784-r9gq2oan author = Tian, Suochen title = Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China date = 2020-05-12 pages = extension = .txt mime = text/plain words = 3729 sentences = 183 flesch = 49 summary = title: Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China Methods: We analyzed retrospective data regarding general characteristics, epidemiologic history, underlying chronic diseases, clinical symptoms and complications, chest computed tomography findings, biochemical monitoring, disease severity, treatments, and outcomes among 37 adult patients with COVID-19. Patient diagnosis, release from quarantine, and disease severity among all cases were determined according to the "Protocol for the Diagnosis and Treatment of Novel Coronavirus Pneumonia" issued by the National Health Commission of the People's Republic of China and the National Administration of Traditional Chinese Medicine (8, 9) . The present study retrospectively analyzed the general characteristics, epidemiological history, chronic underlying diseases, clinical symptoms, complications, chest computed tomography (CT) findings, biochemical features, disease severity, treatment plans, and outcomes of 37 patients. cache = ./cache/cord-262784-r9gq2oan.txt txt = ./txt/cord-262784-r9gq2oan.txt === reduce.pl bib === id = cord-263061-ocplcdiv author = Rivetti, Luigi title = Management of Pacemaker Implantation during COVID-19 Infection date = 2020-10-24 pages = extension = .txt mime = text/plain words = 1362 sentences = 65 flesch = 46 summary = This is the first case of complete atrioventricular block in a symptomatic patient affected by the COVID-19 infection treated with early pacemaker implantation to minimize the risk of virus contagion. Recently, the European Society of Cardiology (ESC) Guidance [2] and Italian position paper [3] about the treatment of cardiovascular (CV) disease in COVID 19 infection patients have been published; however, the suggested management of atrioventricular (AV) conduction disorder patients is not matching between the two proposed guidelines. Hence, the ESC recommendation [2] suggested a medical drug approach with isoprenaline and atropine and the implantation of temporary PM (tPM), leading the potential pPM after recovery from the COVID-19 infection. Conversely, the Italian position paper [3] recommends avoiding in any cases the tPM for risk infection, thus preferring early pPM implantation. cache = ./cache/cord-263061-ocplcdiv.txt txt = ./txt/cord-263061-ocplcdiv.txt === reduce.pl bib === id = cord-262987-7h91n9ro author = Bin Traiki, Thamer A. title = Impact of COVID-19 pandemic on patient satisfaction and surgical outcomes: A retrospective and cross sectional study date = 2020-08-21 pages = extension = .txt mime = text/plain words = 3326 sentences = 168 flesch = 49 summary = OBJECTIVE: The objective of this study was to evaluate the impact of the COVID-19 pandemic on patient satisfaction and surgical outcomes at King Khalid University Hospital in Saudi Arabia. In light of the above, systematized research is needed to understand the change, if any, in the dynamics of patient care, satisfaction, and post-surgical outcomes with regards to revised infrastructure and policies in hospitals in the wake of infectious pandemics like COVID-19. During study period, there were confirmed COVID-19 cases among health care workers (5 cases) and patients (11 cases) in our hospital, and the hospital administration implemented new polices and strict preventative measures to minimize the rate of adverse surgical outcomes among patients, which is also confirmed by the higher level of patient's satisfaction as detailed above. cache = ./cache/cord-262987-7h91n9ro.txt txt = ./txt/cord-262987-7h91n9ro.txt === reduce.pl bib === id = cord-262998-cugd2t1l author = Singh, Vishwendra title = The novel coronavirus and challenges for general and paediatric dentists date = 2020-05-02 pages = extension = .txt mime = text/plain words = 1325 sentences = 83 flesch = 48 summary = Frequent hand washing lasting at least 20 s with soap and water, use of hand sanitizers with at least 60% alcohol, avoiding touching mucosal surfaces (mouth, nose, eyes) with unwashed hands, practicing proper cough etiquette, wearing a face mask (if symptomatic), limiting exposure to affected people and maintaining a distance of at least 2 m from others are the suggested preventive steps [1] . It is therefore imperative that guidelines and protocols are made for effectively and efficiently handling patients with COVID-19 in the dental clinic and minimizing risk of nosocomial transmissions. Patients with respiratory infections (current or in the last 48 h) and those with travel histories to COVID-19-affected regions should be reported to the health department and should be rescheduled. The International Association of Paediatric Dentistry [13] has also made recommendations for parents to maintain optimal oral health of children and avoiding dental clinic visits: cache = ./cache/cord-262998-cugd2t1l.txt txt = ./txt/cord-262998-cugd2t1l.txt === reduce.pl bib === id = cord-263292-qjfe2t9v author = Sansone, A. title = Addressing male sexual and reproductive health in the wake of COVID-19 outbreak date = 2020-07-13 pages = extension = .txt mime = text/plain words = 3912 sentences = 210 flesch = 39 summary = Despite being a trivial matter for patients in intensive care units (ICUs), erectile dysfunction (ED) is a likely consequence of COVID-19 for survivors, and considering the high transmissibility of the infection and the higher contagion rates among elderly men, a worrying phenomenon for a large part of affected patients. Testicular function in COVID-19 patients requires careful investigation for the unclear association with testosterone deficiency and the possible consequences for reproductive health. However, independently of whether testosterone is a friend or foe for COVID-19, it should be acknowledged that the testis is a target for SARS-CoV-2 and the possibility for long-lasting consequences on the endocrine function exists, even for recovered patients. Drugs such as β-blockers and antihypertensive agents, routinely used in COVID-19 patients, have the potential to impair sexual function [41] ; therefore, both the cardiovascular consequences and their treatment might ease progression from subclinical to a clinically overt ED [42, 43] . cache = ./cache/cord-263292-qjfe2t9v.txt txt = ./txt/cord-263292-qjfe2t9v.txt === reduce.pl bib === id = cord-263055-4f25h9l4 author = Fogarty, Helen title = More on COVID‐19 coagulopathy in Caucasian patients date = 2020-05-25 pages = extension = .txt mime = text/plain words = 1191 sentences = 67 flesch = 39 summary = We are grateful for the comments of Marrietta et al, [1] and welcome the opportunity to provide further details on the coagulopathy observed in our patients with COVID-19 infection [2]. The weight-adjusted low molecular weight heparin (LMWH) thromboprophylaxis used in the study is that routinely used for hospital in-patients in our institution, consistent with national recommendations [3,4] With respect to the cohort of patients with COVID-19 enrolled in our study, it is important to highlight that 74% of patients received enoxaparin 40mg (4000 IU) subcutaneously once daily. This hypothesis is supported by emerging data suggesting that the incidence of thrombotic complications in critically ill patients with COVID-19 may be >30%, even in patients receiving LMWH thromboprophylaxis. From the literature, it is clear that other centres have already elected to institute increased LMWH doses for selected patients with severe COVID-19 infection. cache = ./cache/cord-263055-4f25h9l4.txt txt = ./txt/cord-263055-4f25h9l4.txt === reduce.pl bib === id = cord-263285-89zqgqx1 author = Sethi, Sanjum S. title = Right Ventricular Clot in Transit in COVID-19: Implications for the Pulmonary Embolism Response Team date = 2020-05-29 pages = extension = .txt mime = text/plain words = 1855 sentences = 117 flesch = 45 summary = After presenting a case of right ventricular thrombus in a COVID-19 patient, we discuss the unique challenges in the workup and treatment of COVID-19 patients highlighting our COVID-19 modified pulmonary embolism response team (PERT) algorithm. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19related critical illness and multiorgan dysfunction in a subset of those infected. Given these findings, the pulmonary embolism response team (PERT) was consulted and the patient was given 100 mg (over 2 hours) of tissue-type plasminogen activator (tPA) and systemic anticoagulation with unfractionated heparin once the tPA infusion was complete. The usual risk stratification schema for acute pulmonary embolism rely on a combination of hemodynamic clinical parameters, such as hypoxemia, tachycardia, and hypotension along with serum biomarkers, such as troponin or brain natriuretic peptide followed by confirmatory imaging tests. cache = ./cache/cord-263285-89zqgqx1.txt txt = ./txt/cord-263285-89zqgqx1.txt === reduce.pl bib === id = cord-263214-h6lkvlj3 author = Bassi, Massimiliano title = BEDSIDE TRANSCERVICAL-TRANSTRACHEAL POST-INTUBATION INJURY REPAIR IN A COVID-19 PATIENT date = 2020-04-22 pages = extension = .txt mime = text/plain words = 1319 sentences = 89 flesch = 42 summary = title: BEDSIDE TRANSCERVICAL-TRANSTRACHEAL POST-INTUBATION INJURY REPAIR IN A COVID-19 PATIENT We report the case of a COVID-19 patient developing pneumomediastinum and subcutaneous emphysema secondary to post-intubation tracheal injury. We performed a bedside tracheal injury surgical repair, after failure of conservative management, with resolution of pneumomediastinum and subcutaneous emphysema and improvement of patient's conditions. However, some patients need hospitalization for respiratory support and a relevant rate (ranging between 9.8 and 15.2%) requires oro-tracheal intubation (OTI) for invasive ventilation. We present a case of a COVID-19 patient who develops massive pneumomediastinum and subcutaneous emphysema for post-intubation tracheal injury. Considering the hemodynamic and respiratory instability after conservative management, a bedside surgical tracheostomy with primary suture of the tracheal lesion was performed. In order to reduce the risk of epidemic spread and avoid transporting, in absence of a COVID-19 dedicated operating room, the procedure was performed bedside. cache = ./cache/cord-263214-h6lkvlj3.txt txt = ./txt/cord-263214-h6lkvlj3.txt === reduce.pl bib === id = cord-263064-n4c0m5hn author = Choudhury, Ivana title = COVID-19 as a Possible Cause of Functional Exhaustion of CD4 and CD8 T-cells and Persistent Cause of Methicillin-Sensitive Staphylococcus aureus Bacteremia date = 2020-07-04 pages = extension = .txt mime = text/plain words = 2242 sentences = 117 flesch = 42 summary = We report a case of a 73-year-old male with a history of diabetes mellitus, osteomyelitis, methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia who recently completed an extended intravenous course of cefazolin eight days back, and presented with MSSA bacteremia complicated by epidural abscess, endocarditis, and aortic root abscess. A 73-year-old male recently treated for methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia secondary to presumed source of non-healing diabetic foot ulcer (completed a six weeks course of intravenous (IV) cefazolin eight days ago, negative transesophageal echocardiogram (TEE)) presented to our emergency department with lower back pain with extension to the left flank region, urinary incontinence, and an altered mental status. For a patient with MSSA bacteremia and COVID-19, such as ours, CD4 and CD8 Tcell functional exhaustion may be why our patient required an extended course of IV antibiotic therapy. Our patient presented with a recurrent and persistent MSSA bacteremia and osteomyelitis, complicated by a spinal epidural abscess, bioprosthetic valve endocarditis and aortic root abscess despite appropriate antibiotic therapy. cache = ./cache/cord-263064-n4c0m5hn.txt txt = ./txt/cord-263064-n4c0m5hn.txt === reduce.pl bib === id = cord-263716-ywsm11aw author = Zhou, Yifan title = Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management date = 2020-05-04 pages = extension = .txt mime = text/plain words = 1795 sentences = 145 flesch = 60 summary = Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. At the later clinical symptomatic phase, the immune system is fully activated and the disease may enter the severe infection stage in this phase. Although many patients are known for their respiratory symptoms, they had neurological symptoms in their first 1–2 days of clinical symptomatic phase, and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase. 3 However, we have found that many patients had neurological symptoms in their early stages, 4 and ischaemic stroke often happened around 2 weeks after the onset of infection. 9 Patients with COVID-19 often have insidious clinical symptoms, without fever or coughing, even though their lungs may have rather severe damages. His nucleic acid testing of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was positive. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China cache = ./cache/cord-263716-ywsm11aw.txt txt = ./txt/cord-263716-ywsm11aw.txt === reduce.pl bib === id = cord-262878-ygvbqmxd author = de Carranza, María title = Aortic thrombus in patients with severe COVID-19: review of three cases date = 2020-07-09 pages = extension = .txt mime = text/plain words = 1895 sentences = 93 flesch = 39 summary = Thrombotic arterial events (APE or cerebral stroke) have been previously related to other viral infections, especially among HIV patients, but no acute aortic events have been reported [10] . In our hospital, we established a specific screening protocol to rule out APE in COVID-19 patients with a significant increase of D-Dimer, even with the improvement of clinical and analytical parameters. CXR presented a rapid progression of opacities and a significant increase in acute reactants such as ferritin and IL-6 were detected, so a single dose of 600 mg of tocilizumab was administered following hospital protocols (severity criteria). We have described three moderate-severe COVID-19 patients over 60 years with cardiovascular risk factors, who presented aortic thrombus despite the use of LMWH prophylaxis, in slow and poor clinical progression with highly increased inflammatory markers. Our local incidence for incidental aortic thrombus is 0.75% in moderate-severe COVID-19 patients, representing 6.6% of 45 cases of arterial thrombosis (including pulmonary embolism). High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients cache = ./cache/cord-262878-ygvbqmxd.txt txt = ./txt/cord-262878-ygvbqmxd.txt === reduce.pl bib === id = cord-263046-3aerbonz author = Hadfield, James N. title = The Evolving COVID-19 Effect on Hip Fracture Patients date = 2020-06-15 pages = extension = .txt mime = text/plain words = 1311 sentences = 70 flesch = 52 summary = Despite this, we have had outbreaks of COVID-19 infections in green zone wards, most notably in our elderly hip fracture patients who tested negative on admission but then became COVID positive in the days after surgery. Early observations and a departmental audit of hip fracture patients admitted during March and April of this year (surgically stabilised) demonstrated a trend to higher 30-day mortality in patients who subsequently tested COVID positive after surgery compared to those who did not. During the coronavirus pandemic, surgical teams operating on COVID-19 positive patients were subject to stringent personal protective equipment (PPE) protocols in theatre. Given the likely increased mortality associated with COVID-19, it is essential that we ensure vulnerable patient groups such as hip fractures continue to receive optimal care regardless of infection status. It can be concluded that patients who present to hospital with a hip fracture and have an initial positive COVID-19 test contracted the virus prior to admission. cache = ./cache/cord-263046-3aerbonz.txt txt = ./txt/cord-263046-3aerbonz.txt === reduce.pl bib === id = cord-263031-cco2vh0f author = Vultaggio, Alessandra title = Considerations on Biologicals for Patients with allergic disease in times of the COVID‐19 pandemic: an EAACI Statement date = 2020-06-05 pages = extension = .txt mime = text/plain words = 2870 sentences = 177 flesch = 41 summary = We discuss immunological and clinical considerations for patients on biologic agents (biologicals)targeting the type 2 inflammatory response due to difficult-to-treat allergic diseases in the context of COVID-19. In other coronavirus infections such as severe acute respiratory syndrome (SARS), type I IFN are critical for the initiation of immune response and virus clearance. In line with a paucity of mechanistic data on COVID-19 in the context of type 2 inflammation, knowledge on the disease course in patients treated with biologicals targeting type 2 inflammation due to severe asthma or other atopic diseases, such as CSU, AD and CRSwNP, is scarce to absent. In the past years, new biological therapies for severe asthma, atopic dermatitis (AD), chronicrhinosinusitis with nasal polyps (CRSwNP) and chronic spontaneous urticaria (CSU) have been developed targeting different aspects of the type 2 immune response. cache = ./cache/cord-263031-cco2vh0f.txt txt = ./txt/cord-263031-cco2vh0f.txt === reduce.pl bib === id = cord-263691-ovsi38bx author = Sadler, Diego title = Practical and cost-effective model to build and sustain a cardio-oncology program date = 2020-07-16 pages = extension = .txt mime = text/plain words = 5457 sentences = 265 flesch = 38 summary = This study describes how to establish a successful cardio-oncology program, with limited resources, in order to effectively manage the unique care required by this patient population. There are multiple factors that may lead to decreased healthcare access and poor clinical outcomes for many of these patients, including: the lack of knowledge regarding the association between cancer and heart disease, lack of early detection of potentially cardio-toxic effects of certain cancer-related treatments, the prevalence of an aging population amongst cancer survivors [5] . We defined the success of our program by the ability to start and maintain a new service line in our institution, meeting the needs of a growing patient population, our strong cooperation with the oncology department, the achieved goal of bringing awareness of cardiovascular health in cancer patients, and by specific clinical benefits to multiple patients as described herein. cache = ./cache/cord-263691-ovsi38bx.txt txt = ./txt/cord-263691-ovsi38bx.txt === reduce.pl bib === id = cord-263599-cqol8zf2 author = Goodman, Larry title = Infectious diarrhea date = 1999-07-31 pages = extension = .txt mime = text/plain words = 11532 sentences = 640 flesch = 50 summary = A large number of organisms have been associated with diarrhea in humans, and most laboratories routinely screen for Salmonella, Shigella, and Campylobacter. Patients with these conditions requhe prompt treatment, A large number of organisms have been associated with diarrhea in humans, and most laboratories routinely screen for Salmonella, ShigelEa, and Campylobacter. Incubation periods shorter than 12 hours suggest an enterotoxin-producing organism; fever and white blood cells in the stool are generally associated with an invasive pathogen. A recent report about a food-borne outbreak demonstrated that ETEC was also a cause of diarrhea in patients who had not been traveling.30 ETEC organisms were isolated from 5 people who had attended a labor union banquet in Milwaukee with attendees from throughout the United States. 70 However, similar studies are not available for infections caused by an invasive organism such as Salmonella, Shigella, or Campylobacter or for C d@cileassociated diarrhea. cache = ./cache/cord-263599-cqol8zf2.txt txt = ./txt/cord-263599-cqol8zf2.txt === reduce.pl bib === id = cord-263191-osa3ylkl author = Pericàs, Juan M. title = Hospital at home for the management of COVID-19: preliminary experience with 63 patients date = 2020-09-29 pages = extension = .txt mime = text/plain words = 1729 sentences = 80 flesch = 45 summary = We aimed to describe the characteristics and outcomes of patients with COVID-19 transferred from the hospital to a HaH unit during the peak of the first wave of the pandemic in Barcelona, Spain. (1) Caregiver available 24 h at the patients' home; (2) home conditions allowing patient isolation from cohabitants; (3) early discharge from hospital ward: more than 6 days since the start of symptoms; no fever in the last 24 h; respiratory rate < 22 rpm and oxygen saturation > 95% with F i O2 < 0.35; C Reactive protein < 5 mg/dl or descending, normal LDH or descending, lymphocytes > 800 cells/mm 3 or ascending; no radiological progression of pneumonia; (4) admission from Emergency room: bilateral pneumonia in patient without high-risk factors (> 65 years old, hypertension, chronic obstructive pulmonary disease, cardiovascular disease, diabetes, cancer, and immunosuppression); respiratory infection without pneumonia, or unilobar pneumonia in patients with risk factors. cache = ./cache/cord-263191-osa3ylkl.txt txt = ./txt/cord-263191-osa3ylkl.txt === reduce.pl bib === id = cord-263530-t9ryky6f author = Kamal, Yasmine Mohamed title = Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully date = 2020-09-16 pages = extension = .txt mime = text/plain words = 2480 sentences = 158 flesch = 45 summary = ► Abdominal CT was normal ► Brain MRI with contrast, performed after 2 weeks to comply with our hospital's protocol that only allows COVID-19-negative patient to get in contact with the MRI machine, revealed abnormal signal intensity in the temporal lobe cortex bilaterally in a rather symmetrical fashion. Seven hundred and fifty milligrams of intravenous acyclovir sodium, three times per day, was started empirically before the cerebrospinal fluid (CSF) results were obtained, addressing the possibility of herpes simplex virus (HSV) I and II encephalitis. The early suspicion of COVID-19 encephalitis and performing the appropriate CSF studies was the key to establishing the correct diagnosis and timely management. ► A red flag of the possibility of COVID-19 encephalitis should be raised whenever patients present with abnormal behaviour, acute psychosis, confusion state or drowsiness. cache = ./cache/cord-263530-t9ryky6f.txt txt = ./txt/cord-263530-t9ryky6f.txt === reduce.pl bib === id = cord-263883-7ba0huwy author = Ansarin, Khalil title = Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial date = 2020-07-19 pages = extension = .txt mime = text/plain words = 3119 sentences = 186 flesch = 51 summary = The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ventilation, and mortality in patients with COVID-19. The current study, an open-label, randomized clinical trial, examined the efficacy of early start of oral bromhexine, in the intensive care unit (ICU) admission, rate of mechanical ventilation, and mortality in patients with COVID-19 pneumonia. The data presented in this clinical trial confirmed that the early-onset treatment with oral bromhexine 8 mg three times a day not only effectively mitigated the respiratory symptoms, but also significantly decreased the rate of ICU admissions, intubation, mechanical ventilation, and mortality in COVID-19 disease. The data analysis of this clinical trial also showed that cardinal respiratory symptoms (cough, lassitude, and dyspnea) in patients with COVID-19 disease who received bromhexine treatment was remarkably less than the standard group. cache = ./cache/cord-263883-7ba0huwy.txt txt = ./txt/cord-263883-7ba0huwy.txt === reduce.pl bib === id = cord-263241-qzerj9bs author = Liu, Liu title = Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction date = 2020-08-20 pages = extension = .txt mime = text/plain words = 1538 sentences = 103 flesch = 53 summary = title: Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction In this study, the clinical data from hospitalized patients were retrospectively analyzed at their admission to identify if there is any evidence of proximal tubule injury. The patients were diagnosed and classified according to the "Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 4)." [3] Patients with a history of chronic kidney disease (CKD) and with any abnormal urinalysis result in the past 3 months before admission were excluded. This study found that 10.1% of the patients presented with renal glucosuria, 34.2% with mild proteinuria, 25.8% with hyponatremia, and 20.4% with hypouricemia. The presence of renal glucosuria, mild proteinuria, and hyponatremia in patients with COVID-19 indicated the possibility of proximal tubular injury, highlighting the necessity for further investigation. Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction cache = ./cache/cord-263241-qzerj9bs.txt txt = ./txt/cord-263241-qzerj9bs.txt === reduce.pl bib === id = cord-264327-uzlavmhx author = Singh, Rajat title = Novel Coronavirus Disease 2019 in a Patient on Durable Left Ventricular Assist Device Support date = 2020-04-17 pages = extension = .txt mime = text/plain words = 882 sentences = 59 flesch = 44 summary = To the best of our knowledge, we present here the first confirmed case of COVID-19 in a patient on left ventricular assist device (LVAD) support. In the following days, the patient developed progressive hypotension requiring initiation of vasopressor agents, acute oliguric renal failure requiring continuous renal replacement therapy, and refractory hypoxemia consistent with acute respiratory distress syndrome (ARDS). While it has previously been shown that prone positioning unloads the right ventricle in ARDS due to improved pulmonary pressures, (1) the use of this maneuver in the setting of LVAD has not been well described and may be adversely associated with increase in RV pressures and subsequent RV failure. This report describes the first known presentation of illness secondary to SARS-CoV-2 in a patient with long-term LVAD support. Cellular immunity impaired among patients on left ventricular assist device for 6 months cache = ./cache/cord-264327-uzlavmhx.txt txt = ./txt/cord-264327-uzlavmhx.txt === reduce.pl bib === id = cord-263882-s5oxr6es author = Najar Nobar, Niloufar title = Patients with specific skin disorders who are affected by COVID‐19: what do experiences say about management strategies? : A systematic review date = 2020-06-18 pages = extension = .txt mime = text/plain words = 2543 sentences = 145 flesch = 41 summary = It seems that in patients with any severe and serious dermatologic disorders, under treatment with systemic agents, if there is not any suspicion about concurrent infection or any high risk exposures, not only it is not recommend to cessation therapy but only emphasize that these drugs could prevent disease flare-up and control cytokine storm that both in a negative direction, affect the COVID-19 course (41) (42) (43) (44) (45) (46) (47) (48) . So in this systematic review we focused on specific patient groups with a dermatologic disorder (usually under therapy) that concomitantly have been infected by the new corona virus and summed up their data in all aspects of underlying and infectious disease course and management. At the time of the COVID-19, the biologic agents were discontinued except for one case (which was treated with Guselkumab) but the patients did not report any severe exacerbation of their underlying dermatologic disease despite treatment discontinuation. cache = ./cache/cord-263882-s5oxr6es.txt txt = ./txt/cord-263882-s5oxr6es.txt === reduce.pl bib === id = cord-263066-umvojci8 author = Smondack, P. title = Kinésithérapie et COVID-19 : de la réanimation à la réhabilitation à domicile. Synthèse des recommandations internationales date = 2020-10-13 pages = extension = .txt mime = text/plain words = 5669 sentences = 533 flesch = 63 summary = Ainsi, l'indication doit être discutée en staff pluridisciplinaire et le MK ne doit pas entrer dans la chambre du patient uniquement pour évaluer les besoins en kinésithérapie, mais uniquement quand ces besoins ont été évalués au préalable et que la nécessité d'actes kinésithérapiques a été décidée [14, 18] . Les patients présentant des formes modérées nécessitant une hospitalisation sans passage en réanimation sont également pris en charge dans ces services. Ces mesures d'hygiène, notamment le port du masque chirurgical, le lavage des mains et la distanciation sociale doivent s'appliquer dans la mesure du possible pour tous les patients, même non infectés par le SARS-CoV-2 [4, 10, 15, 20, 34] . Les MK ont donc un rôle essentiel dans la prise en charge des patients atteints de COVID-19 et ce, sur du long terme, plusieurs semaines après la maladie. cache = ./cache/cord-263066-umvojci8.txt txt = ./txt/cord-263066-umvojci8.txt === reduce.pl bib === id = cord-264073-yhztrscf author = Betonico, Gustavo Navarro title = Challenges in COVID‐19 medical response: a nephrology perspective date = 2020-06-20 pages = extension = .txt mime = text/plain words = 1704 sentences = 104 flesch = 47 summary = 2 Some strategies to minimize the risk of spreading SARS-CoV-2 throughout the dialysis units are simple such as a phone call to the patients just before their HD session asking about any signs of fever or respiratory symptoms. All rights reserved Patients infected with COVID-19 often present clinical markers of kidney injury. 5 According to the available reports, Acute Kidney Injury (AKI) occurs in approximately 3 -15% of patients with COVID-19 infection. 6 Most patients with COVID-19 are affected by mild or asymptomatic renal disease, but those who develop AKI usually share the most severe phenotype of the disease, characterized by cytokine storm, acute lung injury and, eventually, hypercoagulability. 11 In general, dialysis indications in COVID-19 patients follow the same recommendations as in other acute kidney injuries. Management of Patients on Dialysis and With Kidney Transplant During Covid-19 Coronavirus Infection Review Intensive care management of coronavirus disease 2019 ( COVID-19 ): challenges and recommendations cache = ./cache/cord-264073-yhztrscf.txt txt = ./txt/cord-264073-yhztrscf.txt === reduce.pl bib === id = cord-264180-0vd3tr9j author = Gupta, Anupam K title = Is It Safe to Perform Lung Surgery During the Coronavirus Pandemic? date = 2020-08-14 pages = extension = .txt mime = text/plain words = 1635 sentences = 107 flesch = 61 summary = All patients who remained for at least one-day inpatient post-lung surgery were assessed to see if they had an increased incidence of coronavirus infection during the hospital stay or at the follow-up office visit. As of April 20, 2020, we have reported 55 cases requiring intensive care unit (ICU) care at our tertiary medical center Boca Raton Regional Hospital (400 bedded hospital) in Florida and over 250 coronavirus positive patients. From February 1, 2020, to April 14, 2020, the patients who underwent lung surgery were evaluated for the incidence of coronavirus infection during the hospital stay and on postoperative follow-up. Patients underwent surgery after triage and if they fulfilled guidelines set by the American College of Surgeons and hospital review board, so that hospital resources were not exhausted during an increasing number of COVID cases in our community. cache = ./cache/cord-264180-0vd3tr9j.txt txt = ./txt/cord-264180-0vd3tr9j.txt === reduce.pl bib === id = cord-263793-bmadusm6 author = Velissaris, Dimitrios title = Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group date = 2020-05-12 pages = extension = .txt mime = text/plain words = 3753 sentences = 227 flesch = 55 summary = In light of the accumulating evidence on the negative predictive value of soluble urokinase plasminogen activator receptor (suPAR), a group of experts from the fields of intensive care medicine, emergency medicine, internal medicine and infectious diseases frame a position statement on the role of suPAR in the screening of patients admitted to the emergency department. The main content of this statement is that sUPAR is a non-specific marker associated with a high negative predictive value for unfavourable outcomes; levels < 4 ng/ml indicate that it is safe to discharge the patient, whereas levels > 6 ng/ml are an alarming sign of risk for unfavourable outcomes. Since the group has shown long-term expertise in the clinical value of suPAR (soluble urokinase plasminogen activator receptor), we decided to frame a position paper on the role of suPAR in the early detection of risk of unfavourable outcome for patients admitted to the ED. cache = ./cache/cord-263793-bmadusm6.txt txt = ./txt/cord-263793-bmadusm6.txt === reduce.pl bib === id = cord-264122-n64tm6qr author = Gaballa, Salem title = COVID-19 Fears May Be Worse Than the Virus: A Case of Cardiogenic Shock Secondary to Post-Myocardial Infarction Ventricular Septum Rupture date = 2020-06-24 pages = extension = .txt mime = text/plain words = 2326 sentences = 133 flesch = 47 summary = title: COVID-19 Fears May Be Worse Than the Virus: A Case of Cardiogenic Shock Secondary to Post-Myocardial Infarction Ventricular Septum Rupture We report a sad and unfortunate case of an 87-year-old female who was experiencing pressure-like chest pain but presented to the emergency room five days later out of fear of catching COVID-19 from the hospital. Ventricular septal rupture (VSR) is an uncommon but fatal mechanical complication of myocardial infarction (MI). Ventricular septal rupture following acute myocardial infarction Post-infarction ventricular septal defect: risk factors and early outcomes Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction: a report from the SHOCK Trial Registry Ventricular septal rupture after acute myocardial infarction Surgical repair of ventricular septal defect after myocardial infarction: outcomes from the Society of Thoracic Surgeons National Database cache = ./cache/cord-264122-n64tm6qr.txt txt = ./txt/cord-264122-n64tm6qr.txt === reduce.pl bib === id = cord-263908-4ti8l2ea author = Gupta, Ritesh title = Diabetes and COVID-19: evidence, current status and unanswered research questions date = 2020-05-13 pages = extension = .txt mime = text/plain words = 3693 sentences = 201 flesch = 46 summary = Similarly, despite the recognition of angiotensin converting enzyme 2 (ACE2) as the receptor for severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), and the role of ACE2 in lung injury; there are conflicting results with the use of angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) in these patients. There is a need to further study the natural course of COVID-19 in patients with diabetes and to understand the individual, regional and ethnic variations in disease prevalence and course. It is not known whether patients with diabetes with well-controlled blood glucose levels have an increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). While one study in China did not find any association of ACE inhibitor use with severity of disease, there was an increased mortality in patients with COVID-19 receiving ACE inhibitors and ARBs in another study [29, 30] . cache = ./cache/cord-263908-4ti8l2ea.txt txt = ./txt/cord-263908-4ti8l2ea.txt === reduce.pl bib === id = cord-264368-p2fwuh0i author = Gozgec, Elif title = Left Ventricular Thrombus in a Patient Infecting by Covid-19 date = 2020-07-28 pages = extension = .txt mime = text/plain words = 246 sentences = 26 flesch = 55 summary = key: cord-264368-p2fwuh0i title: Left Ventricular Thrombus in a Patient Infecting by Covid-19 cord_uid: p2fwuh0i A 74-year-old woman presented with general condition disorder, nausea and vomiting. The patient had general condition disorder but had no known systemic disease, history of trauma, or medication. Thorax computed tomography (CT) showed bilateral pleural effusion, consolidated areas with air bronchogram in the right hilar region, ground-glass densities in some peripheral locations ( Figure 1A) , abnormal enlargement of the left ventricular apex, and a hypodense appearance that could be compatible with thrombus ( Figure 1B-C, asterisks) . With the present findings, the patient was diagnosed with multiple organ failure due to possible COVID-19. The COVID-19 disease, which has been declared a pandemic by the world health organization, has a variable spectrum of symptoms from asymptomatic carriers to multiple organ failure. These patients have been shown to be susceptible to thrombus. Ventricular thrombus as in our case is a very rare condition. cache = ./cache/cord-264368-p2fwuh0i.txt txt = ./txt/cord-264368-p2fwuh0i.txt === reduce.pl bib === id = cord-264751-2l3cqhe2 author = Gawie-Rotman, Moran title = Purpuric rash and fever among hospitalized children aged 0–18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology date = 2019-02-22 pages = extension = .txt mime = text/plain words = 3257 sentences = 171 flesch = 44 summary = 8e11 The purpose of the present study is to describe all the cases with PRF occurring in children aged 0 18 years diagnosed and hospitalized at the pediatric departments of the Soroka University Medical Center, Beer-Sheva, Israel, during the period 2005 2016, and to compare their microbiologic laboratory, clinical, therapeutic and outcome characteristics in relation to the various etiologies of this syndrome. We conducted a retrospective study enrolling all the children aged 0 -18 years hospitalized at the pediatric departments of the Soroka University Medical Center, Beer-Sheva, Israel, during the period 01/2005 12/2016, with a diagnosis of purpuric rash accompanied by a fever >38 C. The aim of the present study was to determine the etiology of all cases of PRF occurring in children aged 0 18 years hospitalized in southern Israel during the period 2005 2016, and compare their microbiologic, laboratory, clinical, therapeutic and outcome characteristics in relation to the various etiologies of this syndrome. cache = ./cache/cord-264751-2l3cqhe2.txt txt = ./txt/cord-264751-2l3cqhe2.txt === reduce.pl bib === id = cord-264647-9r443j3l author = Talamonti, G. title = Spinal epidural abscess in COVID-19 patients date = 2020-09-10 pages = extension = .txt mime = text/plain words = 2920 sentences = 192 flesch = 49 summary = OBJECTIVE: To report the peculiarity of spinal epidural abscess in COVID-19 patients, as we have observed an unusually high number of these patients following the outbreak of SARS-Corona Virus-2. METHODS: We reviewed the clinical documentation of six consecutive COVID-19 patients with primary spinal epidural abscess that we surgically managed over a 2-month period. A primary abscess represents the rarest form of spinal epidural abscess, which is usually secondary to invasive procedures or spread from adjacent infective sites, such as spondylodiscitis, generally occurring in patients with diabetes, obesity, cancer, or other chronic diseases. To our knowledge, cases of spinal epidural abscess in COVID-19 patients have not been reported to date. During the last three months, six patients with SARS-Corona Virus-2 (SARS-COV-2) were referred to us for acute spinal cord syndrome due to primary spinal epidural abscess (SEA) [1] . cache = ./cache/cord-264647-9r443j3l.txt txt = ./txt/cord-264647-9r443j3l.txt === reduce.pl bib === id = cord-264673-67zopf7s author = Shi, Hongbo title = The inhibition of IL-2/IL-2R gives rise to CD8(+) T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia date = 2020-06-08 pages = extension = .txt mime = text/plain words = 3359 sentences = 209 flesch = 55 summary = The count and percentage of lymphocytes were significantly decreased in critical patients compared to common and severe patients with COVID-19 pneumonia. The absolute lymphocyte count in patients with COVID-19 pneumonia was remarkably decreased compared with normal controls (Fig. 1a) . In addition, the percentage of lymphocyte in white blood cells (WBC) decreased in turn in common, severe, and critical patients, and the differences among them were statistically significant (Fig. 1d) . In addition, the expression of IL-2Rβ and IL-2Rγc in common, severe, and critical patients was significantly lower than that in normal Table 1 Clinical categorization of the patients with COVID-19 pneumonia by National Health Commission of China. The most significant finding of this study was the low level of IL-2 in plasma and low expression of IL-2R in PBMC of critical patients, which may result in the remarkable decrease of CD8 + T cell and lymphocytes in critical patients with COVID-19 pneumonia. cache = ./cache/cord-264673-67zopf7s.txt txt = ./txt/cord-264673-67zopf7s.txt === reduce.pl bib === id = cord-264295-7ojvhwb0 author = Maddaloni, Ernesto title = Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II) date = 2020-10-01 pages = extension = .txt mime = text/plain words = 4689 sentences = 203 flesch = 39 summary = Data collected included: demographic information (age and sex); presence of diabetes (defined as at least one random blood glucose value > 200 mg/dl, or fasting blood glucose > 126 mg/dl, or HbA 1c > 6.5%, or self-reported history of diabetes with ongoing anti-diabetes therapy), type of diabetes (type 1, type 2, other); smoking habits (never, ex, current); prior history of hypertension, dyslipidemia, chronic obstructive pulmonary disease (COPD), heart failure, cardiovascular events (myocardial infarction, percutaneous coronary intervention, coronary artery-bass graft or stroke), malignancy (any neoplasia diagnosed within the last five years or active neoplasia); presenting symptoms of SARS-CoV-2 infection (fever, cough, cold, conjunctivitis, chest pain, dyspnea, nausea, vomiting, diarrhea). Logistic regression models adjusted for age and sex were used to investigate associations of the primary and secondary outcomes with diabetes, and with other risk factors explored in the study, namely hypertension, dyslipidemia, COPD, heart failure, previous cardiovascular events, malignancy and smoking status (never vs. cache = ./cache/cord-264295-7ojvhwb0.txt txt = ./txt/cord-264295-7ojvhwb0.txt === reduce.pl bib === id = cord-264449-p3tgjuj4 author = Majumdar, PK title = Orthopaedic Surgery in Times of COVID-19 in India date = 2020-07-17 pages = extension = .txt mime = text/plain words = 1734 sentences = 92 flesch = 45 summary = The fear of asymptomatic carriers in patients and colleagues should not weigh on the decision to operate but should be evaluated by the urgency of the procedure; existing and anticipated COVID-19 cases in the hospital and region; availability of PPE, beds and staff; and finally, age and health of the patient. In one of Indonesian public hospitals, Orthopaedic surgeons are only allowed to perform surgeries on emergency, malignancy, and infection cases, whereas elective surgeries shall be postponed indefinitely. To lessen the number of visits, some Orthopaedic surgeons extend the length of post-operative joint replacement stay of their patients up to 10-14 days to receive the multidisciplinary care, including rehabilitation and wound care. Evidence of COVID-19 transmission from asymptomatic individuals 1 brings challenges to orthopaedic practice in terms of nosocomial transmission, isolation and cohorting requirements and increased post operative complications in undetected individuals. Pre-and post-operative screening in limited-term elective cancer surgery patients during the COVID-19 pandemic cache = ./cache/cord-264449-p3tgjuj4.txt txt = ./txt/cord-264449-p3tgjuj4.txt === reduce.pl bib === id = cord-263628-ac9gld5l author = Sivapalan, Pradeesh title = Proactive prophylaxis with azithromycin and hydroxychloroquine in hospitalized patients with COVID-19 (ProPAC-COVID): a statistical analysis plan date = 2020-10-20 pages = extension = .txt mime = text/plain words = 3487 sentences = 205 flesch = 52 summary = The ProPac-COVID trial evaluates whether combination therapy with macrolide azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy, and pre-emptive treatment of supra-infections can shorten hospitalization duration and reduce the risk of non-invasive ventilation, treatment in the intensive care unit, and death in patients with acute hospital admission and a positive test for 2019-nCoV and symptoms of COVID-19 disease. The objective of this randomized, placebo-controlled, double-blinded multi-center trial is to investigate whether 15-day treatment with azithromycin and hydroxychloroquine added to standard of care can shorten hospitalization and reduce the risk of non-invasive ventilation, admittance to ICU, and death. The interim analysis will focus on reporting the following: selected baseline data (those readily available from the baseline data list below), primary outcome (in an O' Brien-Fleming Plot), and all-cause mortality at 30 days (chi-square or Fisher's exact test, whichever appropriate). cache = ./cache/cord-263628-ac9gld5l.txt txt = ./txt/cord-263628-ac9gld5l.txt === reduce.pl bib === id = cord-262766-ndn6iwre author = Easom, Nicholas title = 68 Consecutive patients assessed for COVID-19 infection; experience from a UK regional infectious disease unit date = 2020-03-06 pages = extension = .txt mime = text/plain words = 2964 sentences = 145 flesch = 45 summary = Clinical assessment of possible infection with SARS-CoV-2, the novel coronavirus responsible for the outbreak of COVID-19 respiratory illness, has been a major activity of infectious diseases services in the UK and elsewhere since the first report of cases in December 2019. In addition, many mild respiratory viral infections were managed as influenza 10 , with significant resource implications, both for healthcare services and patients Here we describe our experience of the first 68 patients we have tested for SARS-CoV-2 at a Regional Infectious Diseases unit (RIDU) in the UK. Specialist Infectious Diseases consultant-delivered assessment of a group of patients who predominantly have mild illness is unlikely to be sustainable, especially as the case-definition broadens to include a wider geographical area and/or COVID-19 patients requiring inpatient care becomes more common in the UK. cache = ./cache/cord-262766-ndn6iwre.txt txt = ./txt/cord-262766-ndn6iwre.txt === reduce.pl bib === id = cord-264504-nnvof29x author = Malentacchi, Maria title = Concomitant brain arterial and venous thrombosis in a COVID‐19 patient date = 2020-06-05 pages = extension = .txt mime = text/plain words = 822 sentences = 53 flesch = 41 summary = COVID‐19 infection can cause a severe pneumonia which, in some cases, can lead to admission in intensive care unit for respiratory support.(1) In severe cases, systemic thrombotic complication has been described, including cerebrovascular disease (5.7‐23% of cases).(2,3) COVID-19 infection can cause a severe pneumonia which, in some cases, can lead to admission in intensive care unit for respiratory support. Our case underlines that one of the main causes for clinical deterioration and death during COVID-19 infection is coagulopathy that can involve both arterial and venous systems. [2] [3] 5 As far as we know, the simultaneous occurrence of venous and arterial thrombosis of the brain has not been described yet, and it could represent an important cause of neurological impairment in patients affected by COVID-19: prompt execution of neuroradiological examination of the Accepted Article parenchyma and post-contrast imaging of both arterial and venous systems could allow to perform a correct diagnosis and to apply the more appropriate treatment strategy. cache = ./cache/cord-264504-nnvof29x.txt txt = ./txt/cord-264504-nnvof29x.txt === reduce.pl bib === id = cord-264889-1vsvcza2 author = Jackson, Craig T. title = The Ties That Bind: A Coronavirus Disease Journey date = 2020-10-16 pages = extension = .txt mime = text/plain words = 1129 sentences = 65 flesch = 55 summary = We certainly could not know that we would face that challenge in complementary roles-as patient and as critical care physician. Like so many other friends from distant pasts, we reconnected on social media, sharing advice and personal experiences during the current pandemic. " Although the critical care community is changing practice to improve outcomes (1-3), our shared experience of COVID delirium-one as patient and the other as physicianfriend-offered a powerful lesson for both of us. Each patient's ties to the outside serve as reminders of the importance of team-the care team and the patient's own team of partner, friends, and family-during the critical care journey. Thus, a partner can become a "project manager" to help share in the patient experience. As friends on a COVID journey, we shared our appreciation of ICU care as a team sport. COVID-19: ICU delirium management during SARS-CoV-2 pandemic COVID-19: What do we need to know about ICU delirium during the SARS-CoV-2 pandemic? cache = ./cache/cord-264889-1vsvcza2.txt txt = ./txt/cord-264889-1vsvcza2.txt === reduce.pl bib === id = cord-264042-4hc2i25r author = Chim, Harvey title = Severe Acute Respiratory Syndrome in a Naval Diver date = 2006-06-17 pages = extension = .txt mime = text/plain words = 2133 sentences = 132 flesch = 50 summary = In the early recovery period, potential problems during diving are caused by inadequate lung ventilation in relation to exercise level and increased breathing resistance attributable to weak respiratory muscles, with corresponding risk of hypoxia and hypercapnia, as well as decreased ability to respond to nonrespiratory problems during diving. From our experience, we suggest that computed tomographic scans of the thorax, lung function tests, and careful follow-up monitoring should play a vital role in the assessment of patients during the convalescent period, before certification of fitness to dive. S evere acute respiratory syndrome (SARS) is an emerging infectious disease that was first reported in Guangdong Province in southern China in November 2002 and subsequently caused outbreaks in Singapore, Hong Kong, Southeast Asia, and Canada. In the week following diagnosis of SARS in this patient, only essential personnel in the diving unit were required to report to work to prevent the possible spread of SARS. cache = ./cache/cord-264042-4hc2i25r.txt txt = ./txt/cord-264042-4hc2i25r.txt === reduce.pl bib === id = cord-263294-9r84f19u author = Chen, Siyu title = Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia date = 2020-04-10 pages = extension = .txt mime = text/plain words = 1069 sentences = 69 flesch = 50 summary = The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID‐19) and provide help for clinical prevention and treatment. All five cases of pregnant women confirmed COVID‐19 were collected among patients who admitted to the Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020. Our study collected a total of five pregnant women with COVID-19, who were hospitalized for regular delivery in Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020 (Table 1 ). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy: report of two cases & review of the literature Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia cache = ./cache/cord-263294-9r84f19u.txt txt = ./txt/cord-263294-9r84f19u.txt === reduce.pl bib === id = cord-264829-ynel6ore author = Momtazmanesh, Sara title = Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool date = 2020-07-13 pages = extension = .txt mime = text/plain words = 7952 sentences = 447 flesch = 48 summary = The aims of this systematic review and meta-analyses were (1) to calculate pooled frequency of newly developed and pre-existing CVD, hypertension, diabetes mellitus, cardiac symptoms as the initial presentations of COVID-19, elevation of cardiac and inflammatory biomarkers, acute hepatic, and renal injury; (2) to investigate association of newly developed and pre-existing CVD (including any acquired cardiac disease, encompassing ischemic and non-ischemic cardiomyopathies, or congenital heart disease) hypertension, and elevated cardiac and inflammatory biomarkers with severity of the disease and mortality; (3) to define the clinical spectrum and mechanisms of the newly developed cardiovascular diseases in the pediatric and adult population, the spectrum of newly developed arrhythmias and electrocardiographic changes and the pathologic findings of cardiac autopsies; and (4) to propose a TRST for timely detection and appropriate pathophysiologically targeted treatment of high-risk COVID-19 patients with associated CVD. cache = ./cache/cord-264829-ynel6ore.txt txt = ./txt/cord-264829-ynel6ore.txt === reduce.pl bib === id = cord-264543-b4zwinh2 author = Daher, Valéria Barcelos title = Anosmia: A marker of infection by the new corona virus date = 2020-06-12 pages = extension = .txt mime = text/plain words = 1719 sentences = 99 flesch = 51 summary = [4] The objective of this case report is to describe anosmia and ageusia as emergent initial symptoms of COVID-19 (Coronavirus Disease 2019). After clinical diagnosis, it was instituted home treatment with Oseltamivir 75 mg an oral tablet every 12 hours for five days, Azithromycin 500mg, one oral tablet per day for five days, Acetylcysteine syrup 40mg /ml 15 ml orally at night for 5 days and dipyrone if pain or fever, resulting in marked improvement of the signals and symptoms presented by the patient in five days, however, with persistence of anosmia and ageusia. In the case described, the patient presented as initial symptoms anosmia (absence of smell) and ageusia (change in taste) followed by odynophagia, cough, low fever, chest pain and mild respiratory distress, so it was considered suggestive of Covid-19 and confirmed, later, by the laboratory examination (RT-PCR) of the patient. [6] This examination was performed on the patient of the case at the time of the diagnosis and during the anosmia period and showed no structural changes. cache = ./cache/cord-264543-b4zwinh2.txt txt = ./txt/cord-264543-b4zwinh2.txt === reduce.pl bib === id = cord-264843-cwtdkylo author = Chen, Justin A. title = COVID-19 and telepsychiatry: Early outpatient experiences and implications for the future date = 2020-07-09 pages = extension = .txt mime = text/plain words = 4033 sentences = 237 flesch = 44 summary = Within psychiatry, a sudden relaxing of insurance and regulatory barriers during the month of March 2020 enabled clinicians practicing in a wide range of settings to quickly adopt virtual care in order to provide critical ongoing mental health supports to both existing and new patients struggling with the pandemic's impact. In this article, we briefly review the extensive literature supporting the effectiveness of telepsychiatry relative to in-person mental health care, and describe how payment and regulatory challenges were the primary barriers preventing more widespread adoption of this treatment modality prior to COVID-19. Finally, we provide clinical suggestions for optimizing telepsychiatry based on our experience, make a call for advocacy to continue the reduced insurance and regulatory restrictions affecting telepsychiatry even once this public health crisis has passed, and pose research questions that can help guide optimal utilization of telepsychiatry as mainstay or adjunct of outpatient psychiatric treatment now and in the future. cache = ./cache/cord-264843-cwtdkylo.txt txt = ./txt/cord-264843-cwtdkylo.txt === reduce.pl bib === id = cord-265052-hfuvm1oh author = Turan, Çağrı title = Change of the diagnostic distribution in applicants to dermatology after COVID ‐19 pandemic: What it whispers to us? date = 2020-06-12 pages = extension = .txt mime = text/plain words = 4090 sentences = 237 flesch = 55 summary = Before and after COVID-19, the diagnostic distribution of patients applied to the dermatology outpatient clinics for three periods consisting of 4-weeks was as in Table 2 . Apart from this, the diagnoses of those who applied to the outpatient clinic more than once during this period were as follows in order of frequency: anogenital warts (n = 19/56, 33.9%), verruca vulgaris (59/365, 16.2%), scabies (17/180, 9.4%), psoriasis (11/140,7 .9%), idiopathic generalized pruritus (17/315, 5.4%), urticaria/angioedema (20/394, 5.1%), atopic dermatitis (14/308, 4.5%), bacterial skin/mucosa diseases (10/268, 3.7%), superficial fungal skin/nail infections (15/503, 3.0%). After the COVID-19 pandemic, which rapidly affected the whole world, there were significant changes in the application to outpatient clinics due to reasons such as measures, call to "stay at home", and panic in the community. In our study, we found a significant increase in the frequency of diagnoses such as idiopathic generalized pruritus, pityriasis rosea, alopecia areata, bacterial skin/mucosa diseases, and zona zoster/post-zoster neuralgia after COVID-19. cache = ./cache/cord-265052-hfuvm1oh.txt txt = ./txt/cord-265052-hfuvm1oh.txt === reduce.pl bib === id = cord-265799-qda5awuc author = Carothers, Chancey title = Acetylcysteine for the Treatment of Suspected Remdesivir‐Associated Acute Liver Failure in COVID‐19: A Case Series date = 2020-10-02 pages = extension = .txt mime = text/plain words = 3152 sentences = 157 flesch = 50 summary = We report two cases of suspected remdesivirassociated acute liver failure (ALF) in patients with COVID-19 in which the liver failure improved with the addition of continuous infusion acetylcysteine and discontinuation of potentially hepatotoxic medications. 10 The EUA fact sheet provided by the manufacturer states that in the original compassionate use program of remdesivir in patients with severe or critical illness with COVID-19, liver function test abnormalities were reported in 12% of patients with a time to onset from first dose ranging from 1-16 days. One published case report by Leegwater discusses a case of acute liver failure 5 days after initiation of remdesivir in a patient with severe COVID-19 pneumonia. The use of the novel antiviral remdesivir in the treatment of COVID-19 pneumonia may put patients at risk of drug-associated acute liver failure. cache = ./cache/cord-265799-qda5awuc.txt txt = ./txt/cord-265799-qda5awuc.txt === reduce.pl bib === id = cord-264779-71s7e18i author = Neumann, Natalie R. title = Medical Toxicology and COVID-19: Our Role in a Pandemic date = 2020-04-30 pages = extension = .txt mime = text/plain words = 1930 sentences = 114 flesch = 42 summary = As medical toxicologists we serve as a fund of knowledge for our healthcare colleagues and the public: we provide physicians with information regarding antidotal therapy, drug-drug interactions, and novel therapeutics. Neumann natalie.neumann@cuanschutz.edu treatment of toxicities born of the use and misuse of approved and alternative therapies is a service our field can readily provide to an otherwise overburdened medical system. Interpreting the nature of end-organ dysfunction as it pertains to therapeutic drug administration and overdose is well within the wheelhouse of medical toxicology and represents both a service our field may provide and a potential research frontier. Lastly, poison centers, historically considered an underutilized source for reporting adverse drug reactions, may be more mindful of tracking and reporting toxicity from novel therapies [26] . Medical experts explain the use and potential adverse effects of chloroquine and hydroxychloroquine for COVID-19 cache = ./cache/cord-264779-71s7e18i.txt txt = ./txt/cord-264779-71s7e18i.txt === reduce.pl bib === id = cord-264972-hrbo3awj author = Yee, Colin title = Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting date = 2016-11-01 pages = extension = .txt mime = text/plain words = 1701 sentences = 93 flesch = 36 summary = title: Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting A retrospective cohort design was used to study the impact of a multiplex respiratory virus panel polymerase chain reaction test in 186 adult patients with suspected influenza-like illness. The objective of our study was to evaluate the impact of the MRVP test on the use of antiviral and antimicrobial therapy among adult patients in a hospital setting (either emergency room or inpatients) with suspected influenza-like illness. We evaluated whether the MRVP test result was associated with the changes in management in antiviral and antibiotic treatment (see the definition in Supplementary Appendix S1), after stratifying by patient location. We conclude that the MRVP test could potentially positively impact the clinical management of respiratory viral infections in adult patients. cache = ./cache/cord-264972-hrbo3awj.txt txt = ./txt/cord-264972-hrbo3awj.txt === reduce.pl bib === id = cord-265053-x70501t3 author = Pourhomayoun, Mohammad title = Predicting Mortality Risk in Patients with COVID-19 Using Artificial Intelligence to Help Medical Decision-Making date = 2020-04-01 pages = extension = .txt mime = text/plain words = 1855 sentences = 105 flesch = 48 summary = In the wake of COVID-19 disease, caused by the SARS-CoV-2 virus, we designed and developed a predictive model based on Artificial Intelligence (AI) and Machine Learning algorithms to determine the health risk and predict the mortality risk of patients with COVID-19. We used several machine learning algorithms including Support Vector Machine (SVM), Artificial Neural Networks, Random Forest, Decision Tree, Logistic Regression, and K-Nearest Neighbor (KNN) to predict the mortality rate in patients with COVID-19. In this study, we proposed a data-driven predictive analytics algorithm based on Artificial Intelligence (AI) and machine learning to determine the health risk and predict the mortality risk of patients with COVID-19. After preprocessing the data, we use machine learning algorithms to develop a predictive model to classify the data, predict the medical condition, and calculate the probability and risk of mortality. Table 1 demonstrates the prediction accuracy for predicting mortality in patients with COVID-19 using 10-fold cross-validation for various machine learning algorithms. cache = ./cache/cord-265053-x70501t3.txt txt = ./txt/cord-265053-x70501t3.txt === reduce.pl bib === id = cord-265721-wmz3wywi author = Saini, Kamal S. title = Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy date = 2020-06-22 pages = extension = .txt mime = text/plain words = 1974 sentences = 99 flesch = 35 summary = Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19. The pharmaceutical industry, contract research organisations (CROs), and academia have spent decades developing drugs for cancer-induced inflammation, immune dysfunction, and coagulopathy; given that this triad is also seen in patients affected by COVID-19, it is reasonable to consider testing selected anticancer agents in a rational manner against this viral illness. cache = ./cache/cord-265721-wmz3wywi.txt txt = ./txt/cord-265721-wmz3wywi.txt === reduce.pl bib === id = cord-265082-gjbabh4g author = Xuan, Tian-ming title = Primary percutaneous coronary intervention in a COVID-19 patient with ST-segment elevation myocardial infarction after lung transplantation: a case report date = 2020-05-09 pages = extension = .txt mime = text/plain words = 1980 sentences = 98 flesch = 45 summary = title: Primary percutaneous coronary intervention in a COVID-19 patient with ST-segment elevation myocardial infarction after lung transplantation: a case report We present an unusual case of a patient with bilateral-lung transplantation due to severe coronavirus disease 2019 , who subsequently suffered complications with acute myocardial infarction and underwent primary percutaneous coronary intervention (PCI). Based on the clinical characteristics of this case, we propose that the possible mechanism of myocardial infarction here included severe pulmonary infection, imbalance between coagulation and fibrinolysis subsequent to lung transplantation, changes in blood flow shear stress, and possible cytokine storms, which in combination led to plaque rupture in the LAD artery. In terms of treating acute myocardial infarction, considering that the patient had recent 2019-nCoV infection and bilateral-lung transplantation, we organized multiple rounds of multi-disciplinary discussions and decided that primary coronary intervention rather than thrombolytic therapy was suitable for the patient. In addition to the patient's underlying severe coronary atherosclerosis, factors such as viral infection, inflammatory cytokine storm, hypoxia, blood loss, and bilateral-lung transplantation may contribute to the pathophysiology of myocardial infarction. cache = ./cache/cord-265082-gjbabh4g.txt txt = ./txt/cord-265082-gjbabh4g.txt === reduce.pl bib === id = cord-264924-ds6jv5ek author = Tambyah, Paul A title = Severe acute respiratory syndrome from the trenches, at a Singapore university hospital date = 2004-11-30 pages = extension = .txt mime = text/plain words = 5458 sentences = 274 flesch = 53 summary = Summary The epidemiology and virology of severe acute respiratory syndrome (SARS) have been written about many times and several guidelines on the infection control and public health measures believed necessary to control the spread of the virus have been published. The epidemiology and virology of severe acute respiratory syndrome (SARS) have been written about many times and several guidelines on the infection control and public health measures believed necessary to control the spread of the virus have been published. The severe acute respiratory syndrome (SARS) coronavirus is a novel pathogen that emerged in southern China at the end of 2002 and because of a single event in a hotel in Hong Kong one night in February 2003, spread to three continents. Mild illness associated with severe acute respiratory syndrome coronavirus infection: lessons from a prospective seroepidemiologic study of health-care workers in a teaching hospital in Singapore cache = ./cache/cord-264924-ds6jv5ek.txt txt = ./txt/cord-264924-ds6jv5ek.txt === reduce.pl bib === id = cord-265278-wf5pbvvt author = Fishman, Jay A. title = Case 29-2020: A 66-Year-Old Man with Fever and Shortness of Breath after Liver Transplantation date = 2020-09-17 pages = extension = .txt mime = text/plain words = 5266 sentences = 317 flesch = 40 summary = In transplant recipiAfter infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viral replication ensues in the respiratory epithelium, followed by viremia and systemic spread to organs by means of the angiotensin-converting-enzyme 2 receptor. 22 Graft rejection and toxic effects from calcineurin inhibitors may be difficult to distinguish from The varied presentation of SARS-CoV-2 infection reflects diversity in host immune responses, notably in immunosuppressed transplant recipients. Although the use of antiinflammatory drugs (e.g., high-dose glucocorticoids or interleukin-6 receptor antagonists) in solid-organ transplant recipients may have the additional benefit of protecting against rejection among patients who are receiving tapering courses of the immunosuppressive agents, especially when calcineurin inhibitors are discontinued because of severe disease, their efficacy in the context of solidorgan transplantation warrants testing in clinical trials. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection cache = ./cache/cord-265278-wf5pbvvt.txt txt = ./txt/cord-265278-wf5pbvvt.txt === reduce.pl bib === id = cord-264952-0t0t4x0y author = Smith, Sean R title = Proposed Workflow for Rehabilitation in a Field Hospital Setting During the COVID‐19 Pandemic date = 2020-05-15 pages = extension = .txt mime = text/plain words = 2973 sentences = 196 flesch = 51 summary = [1, 5] Without rehabilitation, numerous patients may require extra days in the field hospital setting, taking up needed bed space and increasing use of PPE and healthcare personnel. Patients with more impaired function and who have clear barriers to discharge modifiable with rehabilitation intervention -including not being able to navigate steps to enter their house and requiring assistance for transfers -will be triaged to receive as much physical and occupational therapy as resources allow, with physiatry involvement as indicated to help with discharge planning and symptom management. When a field hospital has no dedicated space for rehabilitation, patients should receive appropriate ongoing therapies and be provided with information regarding bed exercises, exercises with family, and home exercise programs that appropriately address the symptoms of the disease. cache = ./cache/cord-264952-0t0t4x0y.txt txt = ./txt/cord-264952-0t0t4x0y.txt === reduce.pl bib === id = cord-265111-d44ireu5 author = D’Ardes, Damiano title = Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids date = 2020-08-31 pages = extension = .txt mime = text/plain words = 3103 sentences = 148 flesch = 45 summary = A longer duration of COVID-19 with delayed clinical healing (symptom-free) occurred in patients presenting at admission a lower PaO(2)/FiO(2) ratio (p < 0.001), a more severe clinical presentation (p = 0.001) and a lower lymphocyte count (p = 0.035). All adult patients were diagnosed with COVID-19 according to World Health Organization (WHO) interim guidance: they had clinical symptoms of COVID-19 and confirmation of SARS-CoV-2 infection through instrumental signs and a positive result on RT-PCR assays of nasopharyngeal swab specimens. The specific inclusive criteria were as follows: (1) patients confirmed by positive detection of SARS-CoV-2 RNA from nasopharyngeal/throat swabs by RT-PCR with clinical data suggesting for COVID-19, (2) patients aged more than 18 years old and (3) patients with a known date of performing different RT-PCR assays. Disease severity and lower lymphocyte levels at admission also predict longer SARS-CoV-2 viral shedding. cache = ./cache/cord-265111-d44ireu5.txt txt = ./txt/cord-265111-d44ireu5.txt === reduce.pl bib === id = cord-265098-u5qssib9 author = Fu, Xin-yan title = Effect of COVID-19 outbreak on the treatment time of patients with acute ST-segment elevation myocardial infarction date = 2020-09-17 pages = extension = .txt mime = text/plain words = 1355 sentences = 80 flesch = 55 summary = title: Effect of COVID-19 outbreak on the treatment time of patients with acute ST-segment elevation myocardial infarction OBJECTIVE: To explore the effect of COVID-19 outbreak on the treatment time of patients with ST-segment elevation myocardial infarction (STEMI) in Hangzhou, China. METHODS: We retrospectively reviewed the data of STEMI patients admitted to the Hangzhou Chest Pain Center (CPC) during a COVID-19 epidemic period in 2020 (24 cases) and the same period in 2019 (29 cases). Cumulative mortality was showed in Kaplan-Meier survival curves after the surgery in the 2020 group was significantly different higher than the 2019 group during the 28 days.The diagnosis and treatment process of STEMI patients during an epidemic should be optimized to improve their prognosis. Suggestions on management strategies for ST-segment elevation acute myocardial infarction (STEMI) combined with novel coronavirus infection Impact of symptom onset to first medical contact time on the prognosis of patients with acute ST-segment elevation myocardial infarction cache = ./cache/cord-265098-u5qssib9.txt txt = ./txt/cord-265098-u5qssib9.txt === reduce.pl bib === id = cord-264610-kxebc12r author = Chen, Yu title = Clinical characteristics of IgG4-RD patients infected with COVID-19 in Hubei, China date = 2020-05-16 pages = extension = .txt mime = text/plain words = 1700 sentences = 98 flesch = 45 summary = title: Clinical characteristics of IgG4-RD patients infected with COVID-19 in Hubei, China Since IgG4-RD patients may be susceptible to infections due to the immune-related disease itself and the medications they take, we conducted a study to investigate COVID-19 infection rate in Hubei IgG4-RD patients during the recent outbreak in Hubei province, and to characterize the clinical manifestation of COVID-19 in IgG4-RD patients. Therefore, theoretically IgG4-RD patients have a high risk of progressing to severe/critical COVID-19 once infected and thus need to be identified and properly treated as early as possible. In summary, we describe the infection status and clinical characteristics of COVID-19 among IgG4-RD patients under the pandemic situation in this study. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in cache = ./cache/cord-264610-kxebc12r.txt txt = ./txt/cord-264610-kxebc12r.txt === reduce.pl bib === id = cord-265818-wme1360n author = Cooley, Laura title = Trust and Communication: Responding to Uncertainty date = 2020-07-15 pages = extension = .txt mime = text/plain words = 562 sentences = 40 flesch = 48 summary = Patients and families often struggle with the uncertainties related to personal health and the delivery of care. Heightened emotional states threaten the quality of communication encounters for both patients/families and clinicians/staff. Encouragingly, despite the recent difficulties threatening relationships in health care, clinicians and staff have resiliently responded to the challenge. A recent article published Harvard Business Review highlighted upward trends in patient experience scores during the spring months of the 2020 COVID-19 pandemic: "For example, ratings of the skill of physicians rose 2.4% nationally, 2.8% in Washington and 10.4% in New York. (2) In this issue of The Journal of Patient Experience, I am pleased to feature several "Special Collection" submissions reflecting the context of COVID-19 and/or Telehealth. While our collective energy may continue to be influenced by the pandemic, this issue also contains an assortment of patient experience research and perspective articles. Implications of the current COVID-19 pandemic for communication in healthcare cache = ./cache/cord-265818-wme1360n.txt txt = ./txt/cord-265818-wme1360n.txt === reduce.pl bib === id = cord-265230-ozyx8u64 author = Takahari, Daisuke title = Managing a gastrointestinal oncology practice in Japan during the COVID-19 pandemic: single institutional experience in The Cancer Institute Hospital of Japanese Foundation for Cancer Research date = 2020-10-21 pages = extension = .txt mime = text/plain words = 5741 sentences = 276 flesch = 42 summary = In order to reduce the use of medical resources to avoid the risk of COVID-19 infections in both cancer patients and health care providers, oncologists now have to draw the line for cancer treatments by maintaining their efficacy while avoiding severe adverse events. By contrast, for treating patients with high risk and/or during the pandemic, we must choose between reducing the intensity of chemotherapy (e.g., omission of the 5-FU bolus for CRC, replacement of infusional 5-FU by capecitabine or S-1 for ESCC, gastric cancer (GC), and CRC), delaying treatment, skipping cycles, or stopping (i.e., treatment maintenance phase and salvage chemotherapy with relatively few benefits). As first-line chemotherapy, for patients with high tumor burden or tumor-related signs/symptoms or low risk of COVID-19 infection, combination of fluoropyrimidine and oxaliplatin (if HER2 is positive, plus trastuzumab) is recommended as a standard regimen [38] . cache = ./cache/cord-265230-ozyx8u64.txt txt = ./txt/cord-265230-ozyx8u64.txt === reduce.pl bib === id = cord-265812-1hcp36cw author = De Jong, Cornelis N. title = Etanercept for steroid-refractory acute graft-versus-host disease: A single center experience date = 2017-10-26 pages = extension = .txt mime = text/plain words = 3168 sentences = 186 flesch = 53 summary = W.; Van der Klift, Marjolein; Cornelissen, Jan J.; Broers, Annoek E. High dose glucocorticosteroids, are currently recommended as first-line treatment for grade II-IV aGVHD resulting in overall complete responses (CR) in 40%-50% of patients. CONCLUSION: Second-line treatment with etanercept does induce responses in SR-aGVHD of the gut but appears to be associated with poor long-term survival even in responding patients. High dose systemic glucocorticosteroids (steroids) are currently recommended as first-line treatment for grade II-IV aGVHD resulting in overall complete responses (CR) in 40%-50% of patients [2, 3] . Studies evaluating second-line treatment with the anti-TFNα agent etanercept have shown promising results with overall response rates of 50-80% [8] [9] [10] . In conclusion, although second-line treatment of SR-aGVHD of the gut with etanercept was associated with a promising initial response rate, overall survival appeared very poor, mainly due to progression of GVHD and opportunistic infections. cache = ./cache/cord-265812-1hcp36cw.txt txt = ./txt/cord-265812-1hcp36cw.txt === reduce.pl bib === id = cord-265967-y4639p9m author = Rottenberg, Yakir title = Geriatric patient-centered care during the COVID-19: Provision of interactions vs. the imposition of isolation date = 2020-06-18 pages = extension = .txt mime = text/plain words = 458 sentences = 40 flesch = 59 summary = title: Geriatric patient-centered care during the COVID-19: Provision of interactions vs. 1 Older persons diagnosed with cancer, their families, and the medical staff face a meticulous trade-off between aggressive physical/social distancing and maintaining as close an interaction with family and community life as possible. This seems to contradict older patients' preference for autonomy and decision-making about their life and health. It can be hypothesized that the COVID-19 virus and the chronic condition of cancer goals of the older patients population increases with age. In most families, the current isolation policy and total uncertainty alongside the fears of older patients with cancer becoming infected contradict the basic physical needs of security, namely, the need to touch, embrace, hear the sound of a familiar voice, and not be abandoned. The illness trajectory of elderly cancer patients across cultures: SIOG position paper Palliative care of cancer in the older patient cache = ./cache/cord-265967-y4639p9m.txt txt = ./txt/cord-265967-y4639p9m.txt === reduce.pl bib === id = cord-265022-p5cab562 author = Kotfis, Katarzyna title = COVID-19: ICU delirium management during SARS-CoV-2 pandemic date = 2020-04-28 pages = extension = .txt mime = text/plain words = 5426 sentences = 256 flesch = 34 summary = Indeed, patients with COVID-19 are at accelerated risk for delirium due to at least seven factors including (1) direct central nervous system (CNS) invasion, (2) induction of CNS inflammatory mediators, (3) secondary effect of other organ system failure, (4) effect of sedative strategies, (5) prolonged mechanical ventilation time, (6) immobilization, and (7) other needed but unfortunate environmental factors including social isolation and quarantine without family. Given early insights into the pathobiology of the virus, as well as the emerging interventions utilized to treat the critically ill patients, delirium prevention and management will prove exceedingly challenging, especially in the intensive care unit (ICU). Many hospitalized patients with COVID-19 will develop delirium, and given early insights into the pathobiology of this virus indicating invasion into the brain stem, as well as the emerging interventions utilized to treat these critically ill patients, delirium prevention and management may prove exceedingly challenging, especially in the intensive care unit (ICU). cache = ./cache/cord-265022-p5cab562.txt txt = ./txt/cord-265022-p5cab562.txt === reduce.pl bib === id = cord-266010-ectnfv5z author = Pediconi, Federica title = Breast imaging and cancer diagnosis during the COVID-19 pandemic: recommendations from the Italian College of Breast Radiologists by SIRM date = 2020-07-13 pages = extension = .txt mime = text/plain words = 2737 sentences = 120 flesch = 39 summary = The Italian College of Breast Radiologists by the Italian Society of Medical Radiology (SIRM) provides recommendations for breast care provision and procedural prioritization during COVID-19 pandemic, being aware that medical decisions must be currently taken balancing patient's individual and community safety: (1) patients having a scheduled or to-be-scheduled appointment for in-depth diagnostic breast imaging or needle biopsy should confirm the appointment or obtain a new one; (2) patients who have suspicious symptoms of breast cancer (in particular: new onset palpable nodule; skin or nipple retraction; orange peel skin; unilateral secretion from the nipple) should request non-deferrable tests at radiology services; (3) asymptomatic women performing annual mammographic follow-up after breast cancer treatment should preferably schedule the appointment within 1 year and 3 months from the previous check, compatibly with the local organizational conditions; (4) asymptomatic women who have not responded to the invitation for screening mammography after the onset of the pandemic or have been informed of the suspension of the screening activity should schedule the check preferably within 3 months from the date of the not performed check, compatibly with local organizational conditions. cache = ./cache/cord-266010-ectnfv5z.txt txt = ./txt/cord-266010-ectnfv5z.txt === reduce.pl bib === id = cord-265934-wjdxqj8h author = Singh, Amrita K. title = A Review of Telemedicine Applications in Otorhinolaryngology: Considerations During the Coronavirus Disease of 2019 Pandemic date = 2020-10-01 pages = extension = .txt mime = text/plain words = 4195 sentences = 282 flesch = 40 summary = 21 Recent studies on remote free flap monitoring provide clear examples of how telemedicine can not only expedite care, but also improve patient outcomes. There is a further need for controlled studies comparing telemedicine to in-person assessment of head and neck cancer patients in terms of cost, safety, surveillance adherence, and oncologic outcomes. published clinical practice guidelines for the management of dysphagia in the COVID-19 pandemic, suggesting use of telemedicine for triage and remote evaluation. 63 High levels of patient satisfaction were also achieved with smartphone-based follow-up of facial cosmetic surgery and reviewing images remotely. Telemedicine has a wide applicability in pediatric ORL for obtaining patient history and assessing need for common surgeries such as obstructive sleep apnea, recurrent tonsillitis, and recurrent otitis media (Table VII) . Utilization of SAF techniques have already proven useful in head and neck oncology consultations, remote otologic and audiologic evaluation, cochlear implant and hearing aid management, laryngeal ultrasonography, nasolaryngoscopy, as well as CT sinus review. cache = ./cache/cord-265934-wjdxqj8h.txt txt = ./txt/cord-265934-wjdxqj8h.txt === reduce.pl bib === id = cord-266456-10tjzqep author = Sadeghipour, Parham title = Management of ST‐segment‐elevation myocardial infarction during the coronavirus disease 2019 (COVID‐19) outbreak: Iranian“247” National Committee's position paper on primary percutaneous coronary intervention date = 2020-04-22 pages = extension = .txt mime = text/plain words = 1438 sentences = 102 flesch = 47 summary = title: Management of ST‐segment‐elevation myocardial infarction during the coronavirus disease 2019 (COVID‐19) outbreak: Iranian"247" National Committee's position paper on primary percutaneous coronary intervention Such safety concerns, along with the acceptable mortality benefit of the new generation of fibrinolytic agents, have placed thrombolytic therapy as a potential first choice on several occasions during the outbreak. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction (ASSENT-4 PCI): randomised trial Impact of coronavirus disease 2019 (COVID-19) outbreak on ST-segment-elevation myocardial infarction care in Hong Kong The management of antiplatelet therapy in acute coronary syndrome patients with thrombocytopenia: a clinical conundrum Management of ST-segment-elevation myocardial infarction during the coronavirus disease 2019 (COVID-19) outbreak: Iranian"247" National Committee's position paper on primary percutaneous coronary intervention cache = ./cache/cord-266456-10tjzqep.txt txt = ./txt/cord-266456-10tjzqep.txt === reduce.pl bib === id = cord-265848-afkeuwup author = nan title = Chapter 2 Emergency Management of Poisoning date = 2007-12-31 pages = extension = .txt mime = text/plain words = 27412 sentences = 1589 flesch = 39 summary = With the use of drugs having a short duration of action, RSI also is advantageous because it is a measure that permits temporary airway control for the patient with mildly compromised airway reflexes who requires gastrointestinal decontamination (lavage followed by activated charcoal administration) but who does not require prolonged intubation. The management of gastrointestinal disturbance in the toxic patient includes following the general principles of blood, fluid, and electrolyte resuscitation, when indicated; judicious use of parenteral antiemetics to control persistent vomiting; specific measures such as antidotal therapy (e.g., in iron or organophosphate poisoning); or interventional therapy, such as charcoal hemoperfusion (in theophylline overdose) or hemodialysis (in lithium overdose), when indicated. cache = ./cache/cord-265848-afkeuwup.txt txt = ./txt/cord-265848-afkeuwup.txt === reduce.pl bib === id = cord-265262-r01u4jr6 author = Cannarella, Rossella title = Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients date = 2020-10-13 pages = extension = .txt mime = text/plain words = 8737 sentences = 471 flesch = 47 summary = Furthermore, recent findings on novel coronavirus disease (COVID-19) epidemiology have shown a greater mortality in male compared with female patients and a role of T in promoting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection of the host cells has been demonstrated. To accomplish the aims of the study, we performed a search on PubMed, Scopus, Ovid and Science Direct, and the following keywords were used: hypogonadism, TD, TRT, blood pressure, hypertension, ischemic heart disease, heart failure, stroke, obesity, insulin, diabetes, metabolic disorders, prostatic hyperplasia, prostate cancer, COVID-19, and SARS-CoV2. 45 In 2017, a meta-analysis including 39 randomized controlled trials (RCTs) and 10 observational studies with a total of about 5500 patients did not find any significant association between TRT and myocardial infarction, stroke, or mortality, even if the quality of the evidence was low. cache = ./cache/cord-265262-r01u4jr6.txt txt = ./txt/cord-265262-r01u4jr6.txt === reduce.pl bib === id = cord-265472-b1s4stvz author = Guimarães, Luísa Eça title = Vaccines, adjuvants and autoimmunity date = 2015-10-31 pages = extension = .txt mime = text/plain words = 14633 sentences = 821 flesch = 40 summary = In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. We can infer that a similar response may be associated with different safety in relation to the development of autoimmune reactions to vaccines, particularly in the patients with genetic predisposition to an enhanced response to vaccine inoculation [85] . HSP was associated with seasonal influenza, influenza A (H1N1), pneumococcal and meningococcal disease, hepatitis A virus (HAV), HBV, anti-human papilloma virus (HPV) vaccines, and following multiple combinations of vaccines, such as typhoid, cholera and yellow fever [139, [171] [172] [173] . Hepatitis B vaccination and undifferentiated connective tissue disease: another brick in the wall of the autoimmune/inflammatory syndrome induced by adjuvants (Asia) cache = ./cache/cord-265472-b1s4stvz.txt txt = ./txt/cord-265472-b1s4stvz.txt === reduce.pl bib === id = cord-266294-ua22udlc author = Koch, Oliver title = 29 Antiviral drugs date = 2010-12-31 pages = extension = .txt mime = text/plain words = 10777 sentences = 526 flesch = 47 summary = Metabolism The hemochromatosis gene polymorphism HFE 187C> G and possibly mitochondrial haplogroup J gave relative protection against lipoatrophy during antiretroviral drug therapy in a trial in which 96 patients were randomized to didanosine þ stavudine or zidovudine þ lamivudine, combined with efavirenz and/ or nelfinavir in AIDS Clinical Trials Group (ACTG) 384 sub-study A5005s (20 C ). Gastrointestinal In a retrospective obser vational study of highly active antiretroviral therapy (HAART), 27 of 50 patients who took indinavir in combination with zidovudine and lamivudine developed nausea and were significantly more likely to stop taking the treatment than those who were taking zidovudine þ lamivudine þ tenofovir (24 c ). cache = ./cache/cord-266294-ua22udlc.txt txt = ./txt/cord-266294-ua22udlc.txt === reduce.pl bib === id = cord-266255-898h9rl1 author = nan title = Full Issue PDF date = 2020-08-31 pages = extension = .txt mime = text/plain words = 17676 sentences = 980 flesch = 45 summary = Thus, in addition to a more severe LHD at baseline, patients whose TR progress represents a subset characterized by an accelerated course of LHD, including a more rapid increase in LA size, pulmonary pressures, and higher rates of new atrial fibrillation, reduction in LVEF, worsening valvular disease, and need for pacemaker or device therapy. Increased LA LGE has been found to be associated with future diagnosis of atrial arrhythmias in patients with preexisting cardiac disease (9) but no study has investigated the prognostic value of LA LGE in a population-based cohort or by use of continuous monitoring. Positron Emission Tomography) study revealed that total sympathetic denervation size independently predicts appropriate ICD therapy for fast VA (7 ACE ¼ angiotensin converting enzyme; ARB ¼ angiotensin-II-receptor blocker; CFR ¼ coronary flow reserve; CI ¼ confidence interval; HED ¼ hydroxyephedrine; HR ¼ hazard ratio; LVEDVi ¼ leftventricular end-diastolic volume index; LVEF ¼ left-ventricular ejection fraction; MBF ¼ myocardial blood flow; NT-proBNP ¼ N-terminal prohormone of brain natriuretic peptide; NYHA ¼ New York Heart Association; RI ¼ retention index. cache = ./cache/cord-266255-898h9rl1.txt txt = ./txt/cord-266255-898h9rl1.txt === reduce.pl bib === id = cord-266079-nv28ppft author = Dai, Jinghong title = Corticosteroid treatment in severe COVID-19 pneumonia: two cases and literature review date = 2020-05-25 pages = extension = .txt mime = text/plain words = 2384 sentences = 141 flesch = 41 summary = Coronavirus disease 2019 (COVID-19) pneumonia, firstly reported in Wuhan, Hubei province, China, has rapidly spread around the world with high mortality rate among critically ill patients. In the following sections, we present two representative confirmed severe COVID-19 cases according to WHO interim guidance [1] who have received corticosteroid treatment during their hospitalization. Clark Russell and his colleagues [4] summarized the available clinical evidence on corticosteroid therapy in severe COVID-19 [5] , Middle East respiratory syndrome (MERS) [6] and influenza [7] against corticosteroid use in 2019 novel coronavirus pneumonia, except in the setting of a clinical trial. Reports showed that the proper use of corticosteroids could reduce the mortality of critically ill SARS patients and shorten their hospital stay without causing secondary infections and other complications [8] . reported that methylprednisolone treatment might be beneficial for patients with COVID-19 who developed acute respiratory distress syndrome (ARDS) [10] . cache = ./cache/cord-266079-nv28ppft.txt txt = ./txt/cord-266079-nv28ppft.txt === reduce.pl bib === id = cord-266469-n484zqq1 author = King, Michael J. title = Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system date = 2020-07-04 pages = extension = .txt mime = text/plain words = 4127 sentences = 209 flesch = 44 summary = title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system Data is rapidly emerging given the novel nature of this devastating disease, with a paucity of published reports investigating abdominal presenting symptoms and subsequent CT imaging findings in COVID-19 patients. The purpose of our study is to describe the demographic, clinical, biological, and lung base CT findings in COVID-19 patients presenting with acute abdominal complaints, either in isolation or in combination with respiratory complaints. In this study, we described demographic, clinical, biological, and lung base CT findings in a population of COVID-19 patients who presented to our Health System with acute abdominal complaints, either in isolation or in combination with respiratory complaints. In conclusion, we report demographic, clinical, biological, and lung base CT findings in a group of patients presenting to our Health System with acute abdominal complaints who were found to have COVID-19. cache = ./cache/cord-266469-n484zqq1.txt txt = ./txt/cord-266469-n484zqq1.txt === reduce.pl bib === id = cord-266583-avhiqlgy author = Kim, Hae Jin title = Ultra-Low-Dose Chest CT in Patients with Neutropenic Fever and Hematologic Malignancy: Image Quality and Its Diagnostic Performance date = 2014-07-18 pages = extension = .txt mime = text/plain words = 4618 sentences = 678 flesch = 59 summary = PURPOSE: The aim of this study was to evaluate the image quality of ultra-low-dose computed tomography (ULDCT) and its diagnostic performance in making a specific diagnosis of pneumonia in febrile neutropenic patients with hematological malignancy. Mean radiation expose dose of ULDCT was 0.60±0.15 mSv. Each observer regarded low-dose CT scans as unacceptable in only four (1.9%), one (0.5%), and three (1.5%) cases of ULDCTs. Sensitivity and area under the ROC curve in making a specific pneumonia diagnosis were 63.0%, 0.65 for reader 1; 63.0%, 0.61 for reader 2; and 65.0%, 0.62 for reader 3; respectively CONCLUSION: ULDCT, with a sub-mSv radiation dose and acceptable image quality, provides ready and reasonably acceptable diagnostic information for pulmonary infection in febrile neutropenic patients with hematologic malignancy cache = ./cache/cord-266583-avhiqlgy.txt txt = ./txt/cord-266583-avhiqlgy.txt === reduce.pl bib === id = cord-266214-l8pmhcd5 author = Wang, Xiaogang title = Management Strategies for Patients After CABG Surgery in the Outbreak of the COVID-19 Pandemic date = 2020-09-21 pages = extension = .txt mime = text/plain words = 2640 sentences = 141 flesch = 46 summary = CONCLUSION: The management strategy here we proposed could improve the outcome of patients after CABG during the pandemic and benefit both cardiovascular patients and health-care workers. According to the data reported by the Chinese Center for Disease Control and Prevention, elderly patients with preexisting medical comorbidities are prone to severe illness and death after infection, which places the patients recovering from CABG surgery at a higher of infection. It is reported that in the over 40,000 confirmed cases, the casefatality rate of patients with CVD, diabetes, or hypertension is notably higher than average, which indicates the control of blood glucose (BG) and blood pressure (BP) playing a significant role in the prevention and outcome of COVID-19 infection for patients after CABG. Self-monitoring of COVID-19-related symptoms, including cough, fever, and dyspnea, is recommended for cardiovascular health-care workers, and a SARS-CoV-2 virus test should be considered when any kind of suspected exposure to infection occurs. cache = ./cache/cord-266214-l8pmhcd5.txt txt = ./txt/cord-266214-l8pmhcd5.txt === reduce.pl bib === id = cord-266463-ci0g1dno author = Lopes, Renato D. title = Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date = 2020-05-13 pages = extension = .txt mime = text/plain words = 5179 sentences = 280 flesch = 47 summary = title: Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Secondary outcomes include progression of COVID-19 disease, all-cause mortality, death from vascular causes, myocardial infarction, stroke, transient ischemic attack, new or worsening heart failure, myocarditis, pericarditis, arrhythmias, thromboembolic events, hypertensive crisis, respiratory failure, hemodynamic decompensation, sepsis, renal failure, troponin, B-type natriuretic peptide, N-terminal-pro hormone and D-dimer levels. The secondary objectives are to compare the impact of continued use versus discontinuation of reninangiotensin system inhibition on COVID-19 disease severity, all-cause mortality, cardiovascular death, acute myocardial infarction, new or worsening heart failure, hypertensive crisis, transient ischemic attack, and stroke at 30 days. Patients ≥18 years of age with a confirmed diagnosis of COVID-19 who are on chronic renin-angiotensin system inhibitor (ACEI/ARB) therapy will be assessed for the BRACE CORONA trial. cache = ./cache/cord-266463-ci0g1dno.txt txt = ./txt/cord-266463-ci0g1dno.txt === reduce.pl bib === id = cord-266429-0xaz8kbs author = Bader, Feras title = Heart failure and COVID-19 date = 2020-07-27 pages = extension = .txt mime = text/plain words = 5003 sentences = 223 flesch = 37 summary = A more recent large global observational study that included 169 hospitals from three continents and close to 9000 patients found coronary artery disease and congestive heart failure (mortality of 15.3%, vs. Pressure guide, physician-directed, patient self-management has been previously shown to not only reduce heart failure related hospitalizations but also lead to higher frequency of medication adjustments including neurohormonal antagonists [59] . When infected by the virus, immunosuppression may influence the typical clinical presentation of COVID-19 patients who are also heart transplant recipients, resulting in unusual symptoms such as gastrointestinal manifestations [65] . Reported cases from a European transplantation center showed that solid organ recipients with COVID-19 had a more severe clinical course and high complications rates when compared with the general populations [65] . Considerations for heart failure care during the coronavirus disease 2019 (COVID-19) pandemic. Association of renin-angiotensin system inhibitors with severity or risk of death in patients with hypertension hospitalized for coronavirus disease 2019 (COVID-19) infection in Wuhan, China cache = ./cache/cord-266429-0xaz8kbs.txt txt = ./txt/cord-266429-0xaz8kbs.txt === reduce.pl bib === id = cord-266722-qfn2dc1q author = Wormser, Gary P. title = Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date = 1987-06-30 pages = extension = .txt mime = text/plain words = 5482 sentences = 272 flesch = 38 summary = Antibiotic therapy and menstruation can have a profound effect on the composition of this group of microorganisms.2 Disturbance of the delicate host-commensal relationship may cause a clinically significant infection due to these "nonpathogens." This may occur in response to the aforementioned factors (eg, pregnancy predisposing to vaginal candidiasis) or because of disruption of the anatomic barrier (eg, local mucosal infection at a site of trauma, or injury from cytotoxic drugs) or in association with exogenous infection (eg, rhinoviral infection leading to secondary bacterial otitis media). The skin lesions are tender and consist of papules and clear vesicles with a surrounding zone of erythema.617 Pharyngitis with tonsillar exudate persisting for 4 or more days with a negative throat culture for group A streptococci, or occurring in association with diffuse lymphadenopathy, splenomegaly or with many atypical lymphocytes on blood smear suggests the possibility of infectious mononucleosis (IM) (Epstein-Barr virus). cache = ./cache/cord-266722-qfn2dc1q.txt txt = ./txt/cord-266722-qfn2dc1q.txt === reduce.pl bib === id = cord-266775-4npowkkz author = Xu, Jun title = Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis date = 2005-10-15 pages = extension = .txt mime = text/plain words = 3449 sentences = 167 flesch = 46 summary = In the present study, we isolated a SARS coronavirus strain from a brain tissue specimen obtained from a patient with SARS with significant central nervous symptoms. In the present study, we isolated a SARS-CoV strain from a brain tissue specimen obtained during autopsy from a patient with SARS who became severely sick and showed significant central nervous symptoms during the course of his illness. Immunohistochemistry stains for N protein of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in a specimen of brain tissue obtained from the patient with SARS during autopsy. With regard to the superinfection with invasive Aspergillus in the brain and other organs of the patient, we think that severe immunodepression resulting from the damage to the immune system induced by SARS-CoV infection, combined with high-dosage treatment with a corticosteroid, provided access for conditional pathogens, causing a superinfection with invasive Aspergillus in multiple organs [24] . cache = ./cache/cord-266775-4npowkkz.txt txt = ./txt/cord-266775-4npowkkz.txt === reduce.pl bib === id = cord-266450-g9vihgbk author = Tran, Michael title = SARS-CoV-2 and pulmonary embolism: who stole the platelets? date = 2020-09-03 pages = extension = .txt mime = text/plain words = 1498 sentences = 93 flesch = 38 summary = Careful attention to his daily platelet count suggested the possibility of immune mediated heparin-induced thrombocytopenia (HIT) which was confirmed by laboratory testing and resolved when anticoagulation was switched to a direct thrombin inhibitor. CONCLUSIONS: Since excessive platelet activation and in situ thrombosis occur in HIT, this case underscores the need to consider that thrombocytopenia in patients with SARS-CoV-2—most of whom receive heparinoids—may be unrecognized HIT. Emerging reports suggest the possibility of HIT developing in SARS-CoV-2 patients receiving heparin anticoagulation [4, 5] . The patient's platelet count decreased from 487 k/uL to a nadir of 91 k/uL over the following 4 days, raising the concern for heparin induced thrombocytopenia (HIT) with an intermediate pretest probability by the 4Ts score of 4 ( Table 1 ). Platelet count and time points for anticoagulation administration and laboratory testing COVID-19 patients receiving heparin-involved treatment. cache = ./cache/cord-266450-g9vihgbk.txt txt = ./txt/cord-266450-g9vihgbk.txt === reduce.pl bib === id = cord-266160-464v4g8o author = Bajaj, Jasmohan S title = Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort date = 2020-07-13 pages = extension = .txt mime = text/plain words = 3689 sentences = 198 flesch = 49 summary = COVID-19 and cirrhosis characteristics, development of organ failures and acute-on-chronic liver failure (ACLF) and mortality (inpatient death+hospice) were compared. Patients with cirrhosis alone had higher cirrhosis-related complications, maximum model for end-stage liver disease (MELD) score and lower BiPAP/ventilation requirement compared with patients with cirrhosis+COVID-19, but CCI and ACLF rates were similar. CONCLUSIONS: In this multicentre North American contemporaneously enrolled study, age/gender-matched patients with cirrhosis+COVID-19 had similar mortality compared with patients with cirrhosis alone but higher than patients with COVID-19 alone. Cirrhosis-alone patients had higher rates of grade III/IV HE, developed a higher model for end-stage liver disease (MELD) score and required more endoscopic procedures, including variceal banding, and large-volume paracentesis, than the cirrhosis+COVID-19 group. We conclude in this multicentre study that patients hospitalised with COVID-19 in the setting of cirrhosis have an inpatient mortality rate that is similar to that of patients admitted due to cirrhosis alone but higher than those admitted with COVID-19 without cirrhosis. cache = ./cache/cord-266160-464v4g8o.txt txt = ./txt/cord-266160-464v4g8o.txt === reduce.pl bib === id = cord-266730-mio282vy author = Li, Long‐quan title = COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis date = 2020-03-23 pages = extension = .txt mime = text/plain words = 1309 sentences = 95 flesch = 58 summary = We statistically analyzed the clinical symptoms and laboratory results of COVID‐19 patients and explained the discharge rate and fatality rate with a single‐arm meta‐analysis. The results of the random effects model meta-analysis showed that the fatality rate of the COVID-19 patients was 5% (95% CI 15, 27 found that the fatality rate of patients with viral pneumonia increased when they had a basic disease and mixed bacterial infection, which was consistent with the results of our study. Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis cache = ./cache/cord-266730-mio282vy.txt txt = ./txt/cord-266730-mio282vy.txt === reduce.pl bib === id = cord-266478-642m488a author = Gino, Bruno title = Automated Inflating Resuscitator (AIR): Design and Development of a 3D-Printed Ventilator Prototype and Corresponding Simulation Scenario Based on the Management of a Critical COVID-19 Patient date = 2020-07-11 pages = extension = .txt mime = text/plain words = 5438 sentences = 334 flesch = 49 summary = title: Automated Inflating Resuscitator (AIR): Design and Development of a 3D-Printed Ventilator Prototype and Corresponding Simulation Scenario Based on the Management of a Critical COVID-19 Patient The aim of this technical report is twofold: first, to describe the design and manufacturing process of the automated inflating resuscitator (AIR), a 3D-printed ventilator training device which operates on the principle of pushing a bag valve mask; second, to present a simulation scenario that can be used for training health professionals how to use this and similar, low-cost, 3D-printed ventilators in the context of ventilator shortages caused by COVID-19. In addition to the description of the ventilator, we also present a simulation case using AIR to train safety, operational ability, crisis resource management, and communication skills. If there is a limited supply of participants, the paramedics team can only be reported by the facilitators, as the main objective of this simulation is training with the use of AIR and care involving a patient with COVID-19. cache = ./cache/cord-266478-642m488a.txt txt = ./txt/cord-266478-642m488a.txt === reduce.pl bib === id = cord-266750-41gth6o0 author = Puzzitiello, Richard N. title = Inflammatory and Coagulative Considerations for the Management of Orthopaedic Trauma Patients With COVID-19: A Review of the Current Evidence and Our Surgical Experience date = 2020-05-14 pages = extension = .txt mime = text/plain words = 3742 sentences = 221 flesch = 39 summary = A better understanding of this relationship can inform the development of evidencebased management strategies in these patients and limit admissions to overcrowded ICUs. To demonstrate and further define these developing theories on the coagulative and inflammatory risks associated with the surgical treatment of trauma patients with COVID-19, we will present an unexpected outcome on such a patient at our institution. In addition, the hypercoagulable state secondary to COVID-19 and the inflammatory load of intramedullary reaming, fat emboli, and pulmonary embolism resulted in a "second hit" that may have cumulatively pushed our patient past a "tipping point" and into respiratory failure (Fig. 4) . The level of cytokine response, hypercoagulability, and pulmonary dysfunction associated with the COVID-19 virus may predispose to a catastrophic "second hit" after even low-energy trauma. Careful consideration and risk/benefit analysis, including preoperative evaluation of systemic inflammation and respiratory status, is paramount in patients with COVID-19 presenting with orthopaedic trauma injuries. cache = ./cache/cord-266750-41gth6o0.txt txt = ./txt/cord-266750-41gth6o0.txt === reduce.pl bib === id = cord-266455-rbblg4pu author = Poole, Stephen title = Rapid syndromic molecular testing in pneumonia: The current landscape and future potential date = 2019-12-03 pages = extension = .txt mime = text/plain words = 4839 sentences = 232 flesch = 35 summary = Syndromic diagnostic testing using novel, rapid multiplexed molecular platforms represents a new opportunity for rapidly targeted antimicrobial therapy to improve patient outcomes and facilitate antibiotic stewardship. This is an FDA approved and CE marked platform that uses nested real-time PCR to detect 34 clinically important respiratory targets (15 semi-quantitative bacterial targets, 3 qualitative atypical bacterial targets, 8 [30] [31] [32] Furthermore, the pneumonia panel detects pathogens in a much higher proportion of samples than culture. Rapid syndromic molecular platforms have the potential to significantly improve the use of antibiotics and clinical outcomes in patient with pneumonia, but high quality randomised controlled trials are urgently required to evaluate their clinical impact. an observational study comparing the performance of two multiplex PCR platforms against routine microbiology for the detection of potential pathogens in patients with suspected hospital acquired/ventilator associated pneumonia (HAP/VAP) across cache = ./cache/cord-266455-rbblg4pu.txt txt = ./txt/cord-266455-rbblg4pu.txt === reduce.pl bib === id = cord-266475-t04pukea author = Balestri, R. title = Late onset of acral necrosis after SARS‐CoV‐2 infection resolution date = 2020-05-26 pages = extension = .txt mime = text/plain words = 862 sentences = 46 flesch = 45 summary = [1] [2] [3] [4] SARS-CoV-2 has been hypothesized as the aetiologic agent of CLL, on the basis of the temporal correlation between the "burst" of skin manifestations and the viral pandemic, even though we have scarce evidence of swab-confirmed infections. Authors have therefore suggested some pathogenetic mechanisms such as a delayed immunemediated reaction to the virus in genetically-predisposed patients 1 or an early IFN-I response in young patients, muting early viral replication but also inducing microangiopathic changes. [4] [5] [6] We would like to report a case of SARS-CoV-2-related acro-ischemia, peculiar for several reasons: i) the patient presented real acral ischemia that progressed toward necrosis; ii) she was otherwise completely asymptomatic; iii) she was on regular medication with warfarin for atrial fibrillation. Characterization of acute acro-ischemic lesions in non-hospitalized patients: a case series of 132 patients during the COVID-19 outbreak cache = ./cache/cord-266475-t04pukea.txt txt = ./txt/cord-266475-t04pukea.txt === reduce.pl bib === id = cord-266905-j9ljwqv0 author = Ecker, Jeffrey L. title = Laboring Alone?: Brief Thoughts on Ethics and Practical Answers During the COVID-19 Pandemic date = 2020-05-15 pages = extension = .txt mime = text/plain words = 3575 sentences = 171 flesch = 57 summary = Condensation: To minimize risk of exposure to health care workers, some have proposed eliminating 4 spouses, partners and other visitors to support women during their labor and delivery. In most institutions, however, labor and delivery units have been rare exceptions to the "no-visitor" 23 rules, for visitors there are felt to have, in the words of the New York Department of Health, an 24 "essential" role in process of care, and not having a partner present for the birth of a child seems 25 unimaginable,unkind and, for some, even traumatic. As 100 noted above, the process of labor and delivery requires close quarters, but it is difficult to estimate the 101 true incremental risk that comes with accompanying and supporting a patient, especially if members of 102 the health care team are symptom free and wearing appropriate PPE. cache = ./cache/cord-266905-j9ljwqv0.txt txt = ./txt/cord-266905-j9ljwqv0.txt === reduce.pl bib === id = cord-266744-31p212aq author = Dick, Lachlan title = Changes in Emergency General Surgery During Covid-19 in Scotland: A Prospective Cohort Study date = 2020-08-28 pages = extension = .txt mime = text/plain words = 2250 sentences = 141 flesch = 48 summary = title: Changes in Emergency General Surgery During Covid-19 in Scotland: A Prospective Cohort Study The proportion of patients undergoing surgery increased (19.1 vs 42.3 per cent, p = < 0.05) as did the mean operating time (102.4 vs 145.7 min, p = < 0.05). CONCLUSION: Covid-19 has significantly impacted the number of admissions to emergency general surgery. Of the 36 patients undergoing surgery during 2020, 5 (13.9 per cent) had a change in the surgical procedure. Furthermore, in our cohort, only 50 per cent of patients diagnosed with acute appendicitis underwent Covid-19 testing. Furthermore, 12 (75 per cent) patients were deemed to require surgical management as opposed to the intercollegiate recommendation of a conservative approach [9] again suggesting an increase in severity. Covid-19 has significantly impacted the number of admissions to emergency general surgery. Author's reply-clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection cache = ./cache/cord-266744-31p212aq.txt txt = ./txt/cord-266744-31p212aq.txt === reduce.pl bib === id = cord-267020-4mpc246u author = Teixeira, Cassiano title = The medical decision-making process in the time of the coronavirus pandemic date = 2020 pages = extension = .txt mime = text/plain words = 2299 sentences = 142 flesch = 45 summary = In this context, we must prevent intuitive decision-making and insecurity from leading us to exhaust the available critical-care beds before they are truly necessary, while still recognizing the importance of rapid decision-making in emergency situations. The disease pandemic caused by the novel coronavirus has triggered significant changes in the medical decision-making process relating to critically ill patients. The disease pandemic caused by the novel coronavirus has triggered significant changes in the medical decision-making process relating to critically ill patients. The disease pandemic caused by the novel coronavirus has triggered significant changes in the medical decision-making process relating to critically ill patients. (2) (3) (4) More experienced doctors use intuitive and automatic cognitive processing -the infamous "clinical eye." Basically, this system relies on heuristics (mental shortcuts) to assess to what extent the patient's symptoms fit the patterns and prototypes of diseases that professionals have stored in their memory. cache = ./cache/cord-267020-4mpc246u.txt txt = ./txt/cord-267020-4mpc246u.txt === reduce.pl bib === id = cord-267142-ys7z7j8j author = Cheema, Marvi title = Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19) date = 2020-04-02 pages = extension = .txt mime = text/plain words = 2462 sentences = 132 flesch = 47 summary = This case emphasizes the importance of ensuring that first-line health care providers, including ophthalmologists, optometrists, emergency physicians, and family physicians, consider COVID-19 on the differential for any patient with recent travel who presents with acute conjunctivitis. At the time of the visits to our clinic (March 3rd and 5th), the patient did not meet provincial health authority recommendations for testing of coronavirus infectious disease 2019 (COVID-19) based on country of travel. 8 Given this, eye care professionals, most notably ophthalmologists, may be the first point of contact in the health care field for patients with possible COVID-19, before the onset of characteristic respiratory symptoms. The case emphasizes the importance for eye care professionals to remain vigilant and consider SARS-CoV-2 as the causative agent in patients presenting with viral conjunctivitis, particularly in high-risk patients with travel to areas of active transmission of the virus. cache = ./cache/cord-267142-ys7z7j8j.txt txt = ./txt/cord-267142-ys7z7j8j.txt === reduce.pl bib === id = cord-266932-567lbktm author = Escalard, Simon title = Early Brain Imaging Shows Increased Severity of Acute Ischemic Strokes With Large Vessel Occlusion in COVID-19 Patients date = 2020-08-19 pages = extension = .txt mime = text/plain words = 1439 sentences = 78 flesch = 47 summary = title: Early Brain Imaging Shows Increased Severity of Acute Ischemic Strokes With Large Vessel Occlusion in COVID-19 Patients METHODS: We performed a comparative cohort study between patients with COVID-19 who had anterior circulation large vessel occlusion and early brain imaging within 3 hours from onset, in our institution during the 6 first weeks of the COVID-19 outbreak and a control group admitted during the same calendar period in 2019. Patients with COVID-19 had more severe strokes than patients without COVID-19, with a significantly lower clot burden score (median: 6.5 versus 8, P=0.016), higher rate of multivessel occlusion (50% versus 8.8%, P=0.005), lower DWI-ASPECTS (Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores; median: 5 versus 8, P=0.006), and higher infarct core volume (median: 58 versus 6 mL, P=0.004). CONCLUSIONS: Early brain imaging showed higher severity large vessel occlusion strokes in patients with COVID-19. Early brain imaging showed higher severity of anterior circulation large vessel occlusion strokes in patients with COVID-19. cache = ./cache/cord-266932-567lbktm.txt txt = ./txt/cord-266932-567lbktm.txt === reduce.pl bib === id = cord-267124-8efdzlc0 author = Wichmann, Dominic title = Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study date = 2020-05-06 pages = extension = .txt mime = text/plain words = 4062 sentences = 240 flesch = 50 summary = In response to the pandemic spread of SARS-CoV-2, the authorities of the German federal state of Hamburg ordered mandatory autopsies in all patients dying with a diagnosis of COVID-19 confirmed by polymerase chain reaction (PCR). During autopsy, tissue samples for histology were taken from the following organs: heart, lungs, liver, kidneys, spleen, pancreas, brain, prostate and testes (in males), ovaries (in females), small bowel, saphenous vein, common carotid artery, pharynx, and muscle. In this autopsy study of 12 consecutive patients who died of COVID-19, we found a high incidence of deep venous thrombosis (58%). In studies that examined deceased patients with COVID-19 without relying on autopsy, no increased rates of pulmonary embolism were observed clinically. To our knowledge, only 3 case reports have been published on patients with COVID-19 who have undergone complete autopsy and a few more in which only lung tissue was examined (7, 8) . cache = ./cache/cord-267124-8efdzlc0.txt txt = ./txt/cord-267124-8efdzlc0.txt === reduce.pl bib === id = cord-266512-xh6zed03 author = Scala, Enrico title = Atopic statusprotects from severe complications of COVID‐19 date = 2020-08-16 pages = extension = .txt mime = text/plain words = 1297 sentences = 70 flesch = 44 summary = In infection, the Th2 response counteractsthe microbicidal Th1 response, which could limit the tissue damage induced by Th1-mediated inflammation (4) on one hand, but also cause a less efficient anti-virus response, as shown in a study on experimental Coronavirus 229E infection in healthy volunteers, where atopy appeared to be associated with a more severe rhinitis score (5) .Further, atopic subjects show a reduced expression of ACE2, the SARS-CoV-2 receptor, which could be associated with reduced susceptibility to the virus (6) . The multiple logistic regression analysis(details in supplementary material) confirmed a significant association between atopic status andmilder COVID-19;non-atopic patients had a significantly higher risk of having severe Covid-19 (OR adj 3.0, 95% CI 1.6-5.7, p =0.001) ( Table 1) In severe SARS-CoV-2 infection hyper-expressed cytokines include IFN-gamma, TNF-alpha, and IL-6, which cause fever, fatigue, flu-like symptoms, vascular leakage due to endothelial dysfunction, cardiomyopathy, hypotension, lung injury, activation of the coagulation cascade, and diffuse intravascular coagulation (7) . cache = ./cache/cord-266512-xh6zed03.txt txt = ./txt/cord-266512-xh6zed03.txt === reduce.pl bib === id = cord-267287-qodj254z author = Pintado, Juan F. title = How COVID-19 has affected Emergent Visits to a Latin-American Trauma Department: Experience at a Peruvian National Trauma Referral Center date = 2020-11-03 pages = extension = .txt mime = text/plain words = 3661 sentences = 180 flesch = 49 summary = The current study's overall aim was to examine the impact of the current COVID-19 outbreak on the number of non-COVID-related patient presentations to a major national emergency traumatology/orthopedics referral center in Latin America. Numbers of non-follow-up patients presenting to the traumatology/ orthopedics service were counted and compared between January through April 2019 and January through April 2020; and between the month immediately prior to the Peruvian government's implementation of national lock-down measures (Feb 16—Mar 15; Period 1) and the month immediately following (Mar 16—Apr 15; Period 2). Our institute, which performs more trauma and orthopedic surgeries than any other center in Peru [6] , was declared a national referral center for patients with suspected or confirmed COVID-19 during the pandemic. On the other hand, strengths include it being the first to report on the impact of the present global crisis on Latin-American traumatology and orthopedic services, and that our institution is our country's largest tertiary referral center for trauma cases within the Peruvian National Health Service. cache = ./cache/cord-267287-qodj254z.txt txt = ./txt/cord-267287-qodj254z.txt === reduce.pl bib === id = cord-267621-oc8bw7ft author = Kevorkian, Jean-Philippe title = Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study date = 2020-09-01 pages = extension = .txt mime = text/plain words = 1196 sentences = 82 flesch = 37 summary = title: Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study 5 Therefore, to address the effectiveness of early short-course corticosteroid/furosemide treatment in the non-critically ill COVID-19 patient, we designed a retrospective observational cohort study. In the corticosteroid/furosemide treatment group, incidence of invasive MV or death given once daily for up to ten days reduced 28-day mortality by one-third among mechanically ventilated COVID-19 patients and by one-fifth among patients treated with oxygen, while no benefit was observed in patients not receiving respiratory support at randomization. To conclude, our data provides evidence that early short-course of corticosteroids combined to furosemide reduces the risk of invasive MV requirement or 28-day mortality in the non-critically ill COVID-19 patients. cache = ./cache/cord-267621-oc8bw7ft.txt txt = ./txt/cord-267621-oc8bw7ft.txt === reduce.pl bib === id = cord-267357-7aap2cte author = Elston, Dirk M. title = The coronavirus (COVID-19) epidemic and patient safety date = 2020-02-16 pages = extension = .txt mime = text/plain words = 604 sentences = 46 flesch = 44 summary = title: The coronavirus (COVID-19) epidemic and patient safety The coronavirus (COVID-19) epidemic and patient safety Dirk M. Elston, MD Charleston, South Carolina I n this issue of the JAAD, Chen et al 1 discuss patient safety measures in a Chinese dermatology clinic during the coronavirus outbreak (2019-nCoV acute respiratory disease), including patient screening, respiratory precautions, and telemedicine consultations. 2, 3 Large health care organizations often address these issues during in-processing of employees, but many dermatologists practice in private clinics and should review existing policies to prepare for the inevitability of contagious patients entering the clinic. Prior outbreaks of virulent coronavirus strains have also been associated with severe respiratory syndromes and patient deaths. 4 Our responsibility for patient and employee safety is not limited to respiratory pathogens. Prevention of transmission of blood-borne infections deserves special mention, and readers should review the JAAD continuing medical education articles that focused on patient safety and blood-borne pathogens (https://www.jaad. cache = ./cache/cord-267357-7aap2cte.txt txt = ./txt/cord-267357-7aap2cte.txt === reduce.pl bib === id = cord-267041-i94lyfsh author = Ellner, Jerrold J. title = Management of acute and chronic respiratory tract infections date = 1988-09-16 pages = extension = .txt mime = text/plain words = 3288 sentences = 178 flesch = 39 summary = ELLNER, M.D. Cleveland, CM Pharyngitis, bronchitis, and pneumonia represent the most common respiratory tract infections. Potentially pathogenic bacteria can be isolated in most sputum specimens from persons with chronic bronchitis, even in the absence of symptoms of acute infectious exacerbation, Although it is true that Streptococcus pneumoniae is isolated in increased quantities when patients experience exacerbation [Sl, it is not clear in the SYMPOSIUM ON CEFIXIME / ELLNER Determination of the Cause of Pneumonia * Is the current condition accurately termed "acute," or is it really chronic? Although the Gram's stain may suggest that the cause of a pneumonia is not bacterial by the finding of inflammatory cells and no organisms, the clinical presentation can be even more useful for distinguishing a bacterial from a nonbacterial infection. The search for elastin fibers appears to be a generally useful adjunct for diagnosis not only in hospitalized patients but in all persons with pneumonia, particularly when symptoms do not fit the classic patterns of either bacterial or nonbacterial syndromes. cache = ./cache/cord-267041-i94lyfsh.txt txt = ./txt/cord-267041-i94lyfsh.txt === reduce.pl bib === id = cord-267525-tg4uwent author = Rezaei, Shawheen J. title = Neuromyelitis optica practice and prescribing changes in the setting of Covid19: A survey of neurologists date = 2020-07-11 pages = extension = .txt mime = text/plain words = 2987 sentences = 149 flesch = 47 summary = PURPOSE: This study reports and analyzes the findings from the responses of 192 neurologists in the United States and Canada to a new survey instrument distributed in April 2020 to assess NMO practice and prescribing changes during the Covid19 pandemic. The objective of this study is to document the prescribing and treatment patterns of neurologists with expertise in NMO patient care during the Covid19 pandemic. Neurologists also indicated several unmet needs for their NMO patients, including improved testing for Covid19, more information on the risks of NMO treatment in this context, and increased telemedicine access. Neurologists across the United States and Canada believe that Covid19 poses a higher-thanbaseline risk of disease among their NMO patients, in part due to the immunosuppressive nature of most NMO treatments currently available and necessarily in use. cache = ./cache/cord-267525-tg4uwent.txt txt = ./txt/cord-267525-tg4uwent.txt === reduce.pl bib === id = cord-268155-b8lqo52f author = Farrugia, Albert title = Plasma from donors convalescent from SARS-CoV-2 infection – A matter of priorities date = 2020-06-12 pages = extension = .txt mime = text/plain words = 443 sentences = 37 flesch = 45 summary = title: Plasma from donors convalescent from SARS-CoV-2 infection – A matter of priorities In the interim, donor panels for hyperimmune Ig production may be constructed and an optimal path for the provision of this medicine may be developed, hopefully with harmonisation between the major regulatory agencies. Convalescent plasma harvested from voluntary donors in state blood services is at risk of being deflected from therapeutic use through preferential patient allocation to clinical trials for other Covid-19 therapies funded by large pharmaceutical companies. Given the continued body of evidence and public effort in the collection and use of convalescent plasma, it is to be hoped that this treatment will be considered as a first line modality and will not be obstructed by commercial considerations. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Effectiveness of convalescent plasma therapy in severe COVID-19 patients Donor centers for convalescent plasma cache = ./cache/cord-268155-b8lqo52f.txt txt = ./txt/cord-268155-b8lqo52f.txt === reduce.pl bib === id = cord-268049-7xqln70d author = Montrief, Tim title = COVID-19 respiratory support in the emergency department setting date = 2020-08-08 pages = extension = .txt mime = text/plain words = 5197 sentences = 337 flesch = 45 summary = DISCUSSION: Patients presenting with SARS-CoV-2 infection are at high risk for acute respiratory failure requiring airway management. [29] [30] [31] [32] Based on currently available evidence, the WHO states that "HFNC and NIV systems with good interface fitting do not create widespread dispersion of exhaled air and therefore should be associated with [a] low risk of airborne transmission." 15 The risk of respiratory pathogen transmission when using HFNC is subject to a variety of factors, including the duration of support, maximal flow rate, patient sneezing or coughing, cannula fit, and patient cooperation. 35 Many guidelines, including those by Australian and New Zealand Intensive Care Society (ANZICS), the WHO, and the Surviving Sepsis Campaign recommend the use of HFNC in COVID-19 patients presenting with acute hypoxemic respiratory failure unresponsive to conventional oxygen therapy. 20 Notably, the SCCM guidelines on the management of critically ill patients with COVID-19 recommend "a trial of NIV with close monitoring and shortinterval assessment for worsening of respiratory failure" if HFNC is not available and there is no urgent indication for intubation. cache = ./cache/cord-268049-7xqln70d.txt txt = ./txt/cord-268049-7xqln70d.txt === reduce.pl bib === id = cord-267300-zbipv9er author = Alalwan, Adel A title = A Hemodialysis Patient with Severe COVID-19 Pneumonia date = 2020-05-06 pages = extension = .txt mime = text/plain words = 2350 sentences = 143 flesch = 48 summary = Even though end-stage renal disease (ESRD) patients are particularly susceptible to COVID-19 infection and can develop severe to critical disease, there are limited studies and case reports about COVID-19 in ESRD patients. Even though ESRD patients are particularly susceptible to COVID-19 infection and can develop severe to critical disease, there are limited studies and case reports about COVID-19 in ESRD patients. We report a case of an ESRD patient on regular hemodialysis with severe COVID-19 pneumonia. This report describes the clinical presentation of this disease in a hemodialysis patient, the diagnostic process, the laboratory and imaging investigations, as well as the course of treatment. reported five cases of COVID-19 disease in hemodialysis patients in Zhongnan Hospital of Wuhan University. Lopinavir-ritonavir and Ribavirin have been used successfully as monotherapies in the treatment of mild COVID-19 pneumonia in hemodialysis patients [8, 10] . COVID-19 in hemodialysis patients: a report of 5 cases cache = ./cache/cord-267300-zbipv9er.txt txt = ./txt/cord-267300-zbipv9er.txt === reduce.pl bib === id = cord-268168-yzvag38x author = Scolnick, Barbara title = Remission from Chronic Anorexia Nervosa With Ketogenic Diet and Ketamine: Case Report date = 2020-07-30 pages = extension = .txt mime = text/plain words = 4653 sentences = 243 flesch = 53 summary = We report the case of a 29 year-old woman who struggled with severe and enduring anorexia nervosa for 15 years, and experienced a complete recovery following a novel treatment of adopting a ketogenic diet followed by ketamine infusions. CONCLUSIONS: This is the first report of a ketogenic diet used specifically for the treatment of anorexia nervosa, followed by a short series of titrated IV ketamine infusions leading to complete remission of severe and enduring anorexia nervosa, with weight restoration, and sustained cessation of cognitive and behavioral symptoms, for 6 months. Complete and sustained remission of chronic anorexia nervosa is quite rare, and the novel use of a ketogenic diet and IV ketamine treatment in this potentially lethal condition suggests avenues for further research, and hope for patients and their families. We report a case of severe and chronic AN treated successfully by adopting a ketogenic (KG) diet for 3 months followed by a series of intravenous ketamine infusions. cache = ./cache/cord-268168-yzvag38x.txt txt = ./txt/cord-268168-yzvag38x.txt === reduce.pl bib === id = cord-268140-s5lailkp author = Atal, Shubham title = IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? date = 2020-06-13 pages = extension = .txt mime = text/plain words = 5174 sentences = 258 flesch = 41 summary = Considering the proven role of cytokine dysregulation in causing this hyperinflammation in the lungs with IL-6 being a key driver, particularly in seriously ill COVID-19 patients, it is crucial to further explore selective cytokine blockade with drugs like the IL-6 inhibitors tocilizumab, sarilumab, and siltuximab. Considering the proven role of cytokine dysregulation in serious COVID-19 and interleukin (IL)-6 being the key driver of this hyperinflammation, which can cause multi-organ failure, a series of clinical trials with IL-6 inhibitors like tocilizumab, sarilumab and siltuximab are underway. Another Italian Phase II open-label trial (NCT04315480) with tocilizumab 8 mg/kg single dose is being conducted in patients with severe multifocal interstitial pneumonia due to COVID-19 to evaluate its role in the virus-induced cytokine storm, in blocking deterioration of lung function or even promoting a rapid improvement of clinical conditions, preventing naso-tracheal intubation and/or death [51] . cache = ./cache/cord-268140-s5lailkp.txt txt = ./txt/cord-268140-s5lailkp.txt === reduce.pl bib === id = cord-267132-nb0j6k3h author = Loveday, H.P. title = epic3: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England date = 2013-12-10 pages = extension = .txt mime = text/plain words = 43396 sentences = 2281 flesch = 43 summary = Clinical effectiveness (i.e. using prevention measures that are based on reliable evidence of efÀ cacy) is a core component of an effective strategy designed to protect patients from the risk of infection, and when combined with quality improvement methods can account for signiÀ cant reductions in HCAI such as meticillin-resistant Staphylococcus aureus (MRSA) and Clostridium difÀ cile. Full text conÀ rms that the article: relates to infections associated with hospital hygiene; is written in English; is primary research (randomised controlled trials, prospective cohort, interrupted time series, controlled before-after, quasi-experimental, experimental studies answering speciÀ c questions), a systematic review or a meta-analysis including the above designs; and informs one or more of the review questions. 334 In a prospective cohort study using data from two randomised trials and a systematic review to estimate rates of PICC-related bloodstream infection in hospitalised patients, the author concluded that PICCs used in high-risk hospitalised patients are associated with a rate of CR-BSI similar to conventional CVCs placed in the internal jugular or subclavian veins (two to À ve per 1000 catheter-days). cache = ./cache/cord-267132-nb0j6k3h.txt txt = ./txt/cord-267132-nb0j6k3h.txt === reduce.pl bib === id = cord-268347-xz6fptol author = Kow, Chia Siang title = Pharmacotherapeutic considerations for systemic rheumatic diseases amid the COVID-19 pandemic: more questions than answers date = 2020-08-16 pages = extension = .txt mime = text/plain words = 2665 sentences = 132 flesch = 33 summary = It is not known for certain if there is an association between any pharmacological agent used for rheumatologic treatment, including biological and non-biological disease-modifying antirheumatic drugs (DMARDs), and an increased risk of COVID-19 acquisition or adverse outcomes from COVID-19, although these agents have been associated with an overall higher risk of infections. To illustrate, the aforementioned prospective case series [3] that included 86 patients from New York with confirmed or presumptive COVID-19 with concurrent immunemediated inflammatory disease reported no increased odds of COVID-19 hospitalization among those who were receiving biological agents or Janus kinase (JAK) inhibitors at baseline [adjusted odds ratio (OR) 0.85; 95% CI 0.71-1.02]. There are proven benefits for initiation or continuation of any pharmacological agents for the management of systemic rheumatic diseases, including treatment with conventional DMARDs and other immunosuppressive agents (e.g. hydroxychloroquine/chloroquine, sulfasalazine, methotrexate, leflunomide, tacrolimus, ciclosporin, mycophenolate mofetil and azathioprine), as well as biological DMARDs, such as abatacept, tocilizumab and JAK inhibitors (e.g. tofacitinib, baricitinib and upadacitinib). cache = ./cache/cord-268347-xz6fptol.txt txt = ./txt/cord-268347-xz6fptol.txt === reduce.pl bib === id = cord-267788-ukz2wz4a author = Jaffe, Allan S title = Myocardial injury in severe COVID-19 infection date = 2020-06-07 pages = extension = .txt mime = text/plain words = 1909 sentences = 121 flesch = 51 summary = [1] [2] [3] [4] In this issue of the European Heart Journal, the group from Wuhan Renmin University describe, in one of the larger cohorts (n = 671) reported to date, the importance of increases in cardiac troponin I (cTnI) in patients with a COVID-19 infection who were sick enough to require respiratory support. However, in critically ill patients, supply-demand imbalance leading to myocardial injury is more common, 10 due to the metabolic stress of the infection because of tachycardia, hypoxia, acidosis, and hypotension with or without substantial pre-existing epicardial coronary disease. Although arrhythmias have been described in the present and other studies of COVID-19, it is not clear that, in the absence of drugs that prolong the QTc interval which some now use as therapy, the incidence of these are greater than one might expect from patients with any severe respiratory infection leading to myocardial injury. cache = ./cache/cord-267788-ukz2wz4a.txt txt = ./txt/cord-267788-ukz2wz4a.txt === reduce.pl bib === id = cord-267947-dnv2xl0h author = Gornet, Jean-Marc title = What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19? date = 2020-04-24 pages = extension = .txt mime = text/plain words = 3745 sentences = 167 flesch = 40 summary = Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. At the outset of the epidemic, there was a reported case of a 22-year-old female patient presenting with isolated febrile diarrhea along with normal blood test and negative fecal culture; on the other hand, chest scan revealed bilateral pneumopathy suggesting COVID-19 [7] . In a recent retrospective study involving 1141 patients presenting with documented infection, the frequency of initially isolated digestive disorders came to 16%, whereas in 96% of cases, injured lungs appeared on CT-scan [8] . This has also been reported in COVID-19, with a well-documented case of positive RT-PCR results in stools (during 7 days after hospital admission there were also 4 other negative RT-PCR test results, 2 on throat swabs, and the other 2 on sputum) in a patient presenting with non-severe bilateral pneumopathy [14] . cache = ./cache/cord-267947-dnv2xl0h.txt txt = ./txt/cord-267947-dnv2xl0h.txt === reduce.pl bib === id = cord-267402-kca05rvz author = South, Kieron title = Preceding infection and risk of stroke: An old concept revived by the COVID-19 pandemic date = 2020-07-24 pages = extension = .txt mime = text/plain words = 6248 sentences = 335 flesch = 41 summary = What follows herein is a detailed summary of the current literature surrounding COVID-19, encompassing the immune and inflammatory responses to infection, thrombotic manifestations and vascular consequences of infection with a focus on possible mechanisms by which these elements may contribute to acute stroke events. 89 This is not the case in COVID-19 (and the previous SARS outbreak) and a recent retrospective cohort study has suggested an incidence of stroke 7-8 times higher in patients hospitalized with COVID-19 infection compared with those hospitalized by influenza, 90 supporting the possibility of a SARS-CoV-2-driven hyper-coagulant state. [91] [92] [93] Obesity, in particular, is emerging as a prominent risk factor in the development of severe COVID-19 disease and is generally associated with increased incidence and increased severity of respiratory viral infection. Notably, the cytokine IL-33 is persistently elevated in obese individuals and is capable of stimulating endothelial cells to release pro-coagulant tissue factor 97 which may expose them to more severe COVID-19 disease and/or stroke. cache = ./cache/cord-267402-kca05rvz.txt txt = ./txt/cord-267402-kca05rvz.txt === reduce.pl bib === id = cord-268254-1mg7a17c author = Liu, Li title = High neutralizing antibody titer in intensive care unit patients with COVID-19 date = 2020-07-20 pages = extension = .txt mime = text/plain words = 3475 sentences = 200 flesch = 53 summary = This study determined the seroprevalence of 733 non-COVID-19 individuals from April 2018 to February 2020 in the Hong Kong Special Administrative Region and compared the neutralizing antibody (NAb) responses of eight COVID-19 patients admitted to the intensive care unit (ICU) with those of 42 patients not admitted to the ICU. In this study, the absence of NAb in the serum of over 733 HKSAR residents indicates that SARS-CoV-2 is unlikely to have spread silently in Hong Kong before its emergence in COVID-19 patients. During our manuscript revision, a preprint paper indicated that SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease [26] . Neutralizing antibodies responses to SARS-CoV-2 in COVID-19 inpatients and convalescent patients. SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications. cache = ./cache/cord-268254-1mg7a17c.txt txt = ./txt/cord-268254-1mg7a17c.txt === reduce.pl bib === id = cord-268252-6g0vbd08 author = Richards, Wayne title = Being a dentist in the pandemic date = 2020-06-26 pages = extension = .txt mime = text/plain words = 524 sentences = 60 flesch = 54 summary = The authors provide information on the COVID-19 pandemic in order to inform front-line dentists. The paper is as essay on the available information relating to: Background to the pandemic • Coronaviruses in general • Pathogenesis • COVID-19 • Clinical manifestations • Patient characteristics • Diagnosis • Protocol for managing the disease in the clinical setting • Transmission dynamics • Transmission dynamics in dentistry practice • Infection control • Mouth rinses • Rubber dam isolation • Anti-retraction handpiece • Appropriate disinfectants • Management of medical waste. The authors apply available international guidelines to provide a protocol for managing possible exposure to patients or those suspected of having a 2019-nCoV infection. Practice point • Cross infection protocols will prove essential to protect dentists, patients and society at large in the current pandemic. In dentistry face to face contact with patients means dental personnel are exposed to respiratory tract secretions, blood, saliva and other contaminated body fluids. cache = ./cache/cord-268252-6g0vbd08.txt txt = ./txt/cord-268252-6g0vbd08.txt === reduce.pl bib === id = cord-268455-btuzihsy author = de Santiago, Javier title = COVID-19: gynecologic cancer surgery at a single center in Madrid date = 2020-07-07 pages = extension = .txt mime = text/plain words = 2968 sentences = 170 flesch = 46 summary = The aim of this study was to evaluate surgical treatment of gynecological cancer patients during the COVID-19 outbreak in our center. During this period, the hospital was divided into two separate areas, independent of each other, assisting COVID-19 cases and at the same time allocating resources to surgical care, follow-up, or ongoing treatments of patients with cancer. Our study showed that we were able to safely manage 126 gynecological cancer surgeries in the COVID free zone during the pandemic, avoiding delays or cancellations. The number of low complexity surgeries with short hospital stays included in the study may have influenced the risk of postoperative contagion, and the fact that the PCR test before surgery was not performed in half of the patients due to low availability could have reduced the diagnosis of the infection. This study, conducted in a partial COVID-19 free hospital, showed that with adequate preventive and protective measures, cancer surgery was possible and did not significantly compromise patients or healthcare workers. cache = ./cache/cord-268455-btuzihsy.txt txt = ./txt/cord-268455-btuzihsy.txt === reduce.pl bib === id = cord-268211-egy8rgtl author = Barrasa, Helena title = SARS-Cov-2 in Spanish Intensive Care: Early Experience with 15-day Survival In Vitoria date = 2020-04-09 pages = extension = .txt mime = text/plain words = 2681 sentences = 181 flesch = 53 summary = Methods: We identified patients from the two public hospitals in Vitoria who were admitted to ICU with confirmed infection by SARS-CoV-2. Conclusion: This early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring mechanical ventilation. Because of mortality reports in Wuhan [5] suggesting a close association, we assessed correlation between plasma procalcitonin at ICU admission and 7-day mortality. Our findings suggest that an oxygenation strategy emphasising optimisation of oxygenation, intubation based on clinical criteria of hyperventilation and avoiding ventilator-induced lung injury associated with non-invasive mechanical ventilation would be life-saving in a significant proportion of patients. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring prolonged mechanical ventilation. cache = ./cache/cord-268211-egy8rgtl.txt txt = ./txt/cord-268211-egy8rgtl.txt === reduce.pl bib === id = cord-268632-p1rsz8fk author = Tartari, Federico title = Herpes zoster in COVID‐19‐positive patients date = 2020-06-12 pages = extension = .txt mime = text/plain words = 366 sentences = 34 flesch = 57 summary = cord_uid: p1rsz8fk 1 The disease was defined as COVID-19 (Coronavirus Disease 2019) 1 and principally affects the respiratory tract with a clinical scenario ranging from common cold to severe pneumonia. 2 The clinical scenario differs with most patients only needing supportive care, while others require admission to an intensive care unit (ICU) for invasive mechanical ventilation. 2 In Italy, the first person-to-person transmission of the SARS-CoV-2 was recorded on February 21, 2020, and to date (04/28/2020) the number of COVID-19 positive subjects is more than 100,000. However, little is known on the cutaneous manifestations of COVID-19-positive patients. [3] [4] [5] We aim to expand our knowledge by reporting four zoster infections in COVID-19-positive patients observed between March and April 2020. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Decreased absolute numbers of CD3+ T cells and CD8+ T cells during aging in herpes zoster patients cache = ./cache/cord-268632-p1rsz8fk.txt txt = ./txt/cord-268632-p1rsz8fk.txt === reduce.pl bib === id = cord-268324-86a0n0dc author = Charitos, Ioannis A title = Special features of SARS-CoV-2 in daily practice date = 2020-09-26 pages = extension = .txt mime = text/plain words = 6117 sentences = 279 flesch = 42 summary = The severe acute respiratory syndrome-coronavirus-2 (commonly known as SARS-CoV-2) is a novel coronavirus (designated as 2019-nCoV), which was isolated for the first time after the Chinese health authorities reported a cluster of pneumonia cases in Wuhan, China in December 2019. The clinical picture of critical patients with severe inflammatory-induced lung disease and with sepsis or septic shock needing intensive care support and mechanical ventilation is characterized by a wide range of signs and symptoms of life-threatening multiorgan dysfunction or failure, including dyspnoea, tachypnoea (respiratory rate of > 30/min), tachycardia, chest pain or tightness, hypoxemia, virus-induced distributive shock, cardiac dysfunction, elevations in multiple inflammatory cytokines, renal impairment with oliguria, altered mental status, functional alterations of organs expressed as laboratory data of hyperbilirubinemia, acidosis [serum lactate level > 2 mmol/L (18 mg/dL)], coagulopathy, and thrombocytopenia. cache = ./cache/cord-268324-86a0n0dc.txt txt = ./txt/cord-268324-86a0n0dc.txt === reduce.pl bib === id = cord-268540-wrjzr3ws author = Park, You Jeong title = Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics date = 2020-08-13 pages = extension = .txt mime = text/plain words = 16363 sentences = 868 flesch = 45 summary = A potential target for drug development for COVID-19 also involves inhibition of ACE2, the host cell receptor for the S protein of SARS-CoV-2 that is primed by TMPRSS2 protease and may prevent the entry of the virus. As previously described, the intermolecular interaction between the viral SP and human ACE2 Phase II CAStem cells will be intravenously injected into patients with or without acute respiratory distress syndrome (ARDS) induced by COVID-19. Phase II Patients with acute respiratory distress syndrome caused by COVID-19 will be treated with intravenous UC-MSCs at a dose 1 million xKg. Patient improvement will be evaluated over three weeks, along with the assessment of the immune profile, investigating the stem cells' effect on the cytokine storm. The similarities in systemic multi-organ complications between H7N9 and Sars-Cov-2 infections, along with direct evidence of the benefits of MSCs transplantation for COVID-19, further supports the potential of stem cells as an effective treatment [138] . cache = ./cache/cord-268540-wrjzr3ws.txt txt = ./txt/cord-268540-wrjzr3ws.txt === reduce.pl bib === id = cord-268531-igjeai8c author = Zerah, Lorène title = Clinical Characteristics and Outcomes of 821 Older Patients With SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards: A Multicenter Retrospective Cohort Study date = 2020-08-26 pages = extension = .txt mime = text/plain words = 4030 sentences = 210 flesch = 46 summary = title: Clinical Characteristics and Outcomes of 821 Older Patients With SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards: A Multicenter Retrospective Cohort Study On multivariate analysis, at COVID-19 onset, the probability of in-hospital mortality was increased with male gender (odds ratio [OR] 1.85; 95% CI 1.30–2.63), ADL score <4 (OR 1.84; 95% CI 1.25–2.70), asthenia (OR 1.59; 95% CI 1.08–2.32), quick Sequential Organ Failure Assessment score ≥2 (OR 2.63; 95% CI 1.64–4.22), and specific COVID-19 anomalies on chest computerized tomography (OR 2.60; 95% CI 1.07–6.46). Although age has been widely reported as a major risk factor for severe COVID-19 and death, no large geriatric cohort of older patients hospitalized in a geriatric ward has been described. The objective of this multicentric French retrospective study was to describe the clinical characteristics and outcomes of a large cohort of older patients with confirmed COVID-19 who were admitted to acute care geriatric wards and to determine the prognostic factors of in-hospital mortality. cache = ./cache/cord-268531-igjeai8c.txt txt = ./txt/cord-268531-igjeai8c.txt === reduce.pl bib === id = cord-268561-vq1uhj5i author = da Silva, Severino Jefferson Ribeiro title = Clinical and Laboratory Diagnosis of SARS-CoV-2, the Virus Causing COVID-19 date = 2020-08-04 pages = extension = .txt mime = text/plain words = 9916 sentences = 594 flesch = 47 summary = 11 The causative agent was identified as a novel CoV, eventually named SARS-CoV-2, and the respiratory syndrome associated with the infection was designated as coronavirus disease-2019 (COVID-19) by the World Health Organization (WHO). In direct tests, the clinical sample is examined directly for the presence of particles, virus antigens, or viral nucleic acids, whereas indirect methods detect the serological response against the infection (Figure 2 ). 11 Culture-based methods for SARS-CoV-2 detection have been used in research and public health laboratories in different parts of the world, but virus isolation is not recommended as a routine diagnostic procedure because it has low sensitivity, it is time-consuming, and it requires BSL-3 containment. 11 In addition to unequivocally confirming the diagnosis of a SARS-CoV-2 infection, regular sequencing of a percentage of patient samples from clinical cases can be used to monitor changes in the viral genome over time and trace transmission patterns. cache = ./cache/cord-268561-vq1uhj5i.txt txt = ./txt/cord-268561-vq1uhj5i.txt === reduce.pl bib === id = cord-268879-ajd7ofc8 author = Hui, David S. title = Contemporary Concise Review 2018: Respiratory infections and tuberculosis date = 2019-03-30 pages = extension = .txt mime = text/plain words = 3689 sentences = 192 flesch = 39 summary = The huge clinical burden of common respiratory viruses, such as respiratory syncytial virus (RSV) and seasonal influenza, on healthcare resources and utilization highlights the importance for developing more effective treatment modalities in order to reduce morbidity and mortality. 20 The therapeutic role of baloxavir in older or immunocompromised patients with severe seasonal or avian A(H7N9) influenza especially with some time delay in administration of the drug later in the clinical course of the infection or in combination with an NAI requires investigation. While the sizeable protective effects of metformin in the abovementioned studies suggest a potential role of the drug as host-directed therapy in the treatment of latent TB infection and active TB, randomized trials are need to delineate its exact role(s) before introduction into clinical practices. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: impact of β-lactam plus macrolide combination therapy cache = ./cache/cord-268879-ajd7ofc8.txt txt = ./txt/cord-268879-ajd7ofc8.txt === reduce.pl bib === id = cord-268886-mpceglk1 author = Bourne, T. title = ISUOG Consensus Statement on rationalization of gynecological ultrasound services in context of SARS‐CoV‐2 date = 2020-04-08 pages = extension = .txt mime = text/plain words = 3086 sentences = 198 flesch = 46 summary = Given the challenges of the current coronavirus (SARS-CoV-2) pandemic and to protect both patients and ultrasound providers (physicians, sonographers, allied professionals), the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) has compiled the following expert-opinion-based guidance for the rationalization of ultrasound investigations for gynecological indications. While these are extremely troublesome conditions, patients and healthcare providers should consider delaying ultrasound evaluation until resolution of the COVID-19 pandemic. Although associated symptoms (mass effect leading to pressure, bladder/bowel symptoms) are not usually acute or life-threatening, they may signal advanced ovarian cancer, in which case, it may be reasonable to recommend that ultrasound assessment should be carried out by an expert soon and appropriate treatment commenced. • Abdominopelvic 'mass' without associated symptoms (SOON or LATER): the healthcare provider may consider delaying the ultrasound evaluation until the resolution of the pandemic if there is a known history of pelvic pathology, such as leiomyoma. cache = ./cache/cord-268886-mpceglk1.txt txt = ./txt/cord-268886-mpceglk1.txt === reduce.pl bib === id = cord-268326-sbz3uk5h author = Bonam, Srinivasa Reddy title = Lysosomes as a therapeutic target date = 2019-09-02 pages = extension = .txt mime = text/plain words = 17899 sentences = 839 flesch = 37 summary = With a focus on lysosomal dysfunction in autoimmune disorders and neurodegenerative diseases — including lupus, rheumatoid arthritis, multiple sclerosis, Alzheimer disease and Parkinson disease — this Review critically analyses progress and opportunities for therapeutically targeting lysosomal proteins and processes, particularly with small molecules and peptide drugs. Alterations in lysosomal functions, either in the fusion processes involved in the general pathways mentioned above or related to the function of lyso somal enzymes and non enzymatic proteins, can result in broad detrimental effects, including failure to clear potentially toxic cellular waste, inflammation, apopto sis and dysregulation of cellular signalling 8 . cache = ./cache/cord-268326-sbz3uk5h.txt txt = ./txt/cord-268326-sbz3uk5h.txt === reduce.pl bib === id = cord-268617-1t7yaoct author = Ismaili, Nabil title = COVID-19 and Gynecological Cancers: A Summary of International Recommendations date = 2020-08-31 pages = extension = .txt mime = text/plain words = 3974 sentences = 216 flesch = 42 summary = Given this epidemiological context, the establishment of guidelines for patients with gynecological cancers, requiring multidisciplinary management during the global COVID-19 pandemic, is crucial to limit their infection while maintaining their chances for a cure. The surgical prioritization is determined according to: The highest priority should be given to the surgical treatment of high-risk cancers, especially those candidates for minimally invasive surgery (such as robotic surgery) and short hospital stay, in addition to potentially curative procedures for early-stage cancers. In stage II endometrial cancer, proceed with radical surgery and consider adjuvant therapy for patients with high-risk factors (same as stage I). For patients with advanced stage (stages III/IV) high-grade epithelial (serous or endometrioid) ovarian cancer, the standard treatment is based on primary debulking surgery and adjuvant chemotherapy (protocol based on the result of the surgery). cache = ./cache/cord-268617-1t7yaoct.txt txt = ./txt/cord-268617-1t7yaoct.txt === reduce.pl bib === id = cord-268952-3j43p9j3 author = Ueda Oshima, Masumi title = Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach date = 2020-09-26 pages = extension = .txt mime = text/plain words = 3636 sentences = 154 flesch = 37 summary = Situated in the initial epicenter of the pandemic, the Blood and Marrow Transplant (BMT) Program at Fred Hutchinson Cancer Research Center (Fred Hutch)/Seattle Cancer Care Alliance (SCCA) was at the forefront of delivering care to transplant patients during the surge of this public health crisis. In early March 2020 when community transmissions resulted in a steep increase of COVID-19 cases in Washington state, the individual risk for hematopoietic cell transplant (HCT) patients who acquired the infection was unknown. In early March 2020, the Institute for Health Metrics and Evaluation at the UW predicted that the COVID-19-driven demand for healthcare resources including acute and intensive care hospital beds and ventilators might exceed the available supply in Washington state and particularly in our region [6] . Once a COVID-19 vaccine is available, vaccination approaches for the posttransplant period in immunosuppressed patients, vaccination of caregivers, family, and clinical staff, and even assessing potential benefits of vaccinating donors prior to stem cell donation will have to be determined. cache = ./cache/cord-268952-3j43p9j3.txt txt = ./txt/cord-268952-3j43p9j3.txt === reduce.pl bib === id = cord-269051-nl0jfqxt author = Patel, Krish title = Use of the IL‐6R Antagonist Tocilizumab in Hospitalized COVID‐19 Patients date = 2020-08-03 pages = extension = .txt mime = text/plain words = 1922 sentences = 108 flesch = 55 summary = Baseline patient demographic and clinical characteristics including severity of COVID-19 illness using the Chinese CDC definition were recorded up to 10 days prior to anti-cytokine therapy. Survival and clinical outcomes were assessed for 42 tocilizumab-treated patients and 41 matched controls for whom at least 7 days of follow-up data were available or who had been discharged or died before 7 days following administration of tocilizumab or the corresponding time for the matched controls. The median time from hospitalization to receipt of tocilizumab therapy was 4 days (IQR, 4) and similar between severely and critically ill patients. At last follow-up 15 (71.4%) severely ill patients have been discharged, 4 (19.0%) died, with 2 (9.5%) remaining hospitalized ( Figure 1G ). In this retrospective cohort study, we report on use of tocilizumab in the treatment of severely and critically ill hospitalized COVID-19 patients. cache = ./cache/cord-269051-nl0jfqxt.txt txt = ./txt/cord-269051-nl0jfqxt.txt === reduce.pl bib === id = cord-268843-zml9lbve author = Cuvelier, Geoffrey D.E. title = Clinical presentation, immunologic features, and hematopoietic stem cell transplant outcomes for IKBKB immune deficiency date = 2018-10-31 pages = extension = .txt mime = text/plain words = 5812 sentences = 253 flesch = 39 summary = In the Canadian province of Manitoba, our group has periodically managed young infants of Northern Cree First Nations (Aboriginal) descent presenting with early-onset and life-threatening viral, bacterial, Mycobacterial, and fungal infections, clinically resembling severe combined immune deficiency (SCID). Herein we describe the clinical presentation, immunologic features, and HSCT outcomes for the largest cohort of infants with IKBKB immune deficiency resulting from complete loss of IKKβ expression published to date. Supporting a more profound immune deficiency are the other six reported patients with IKBKB mutations, who also presented with severe bacterial, fungal and viral infections as young infants. Like IKBKB immune deficiency, patients with hypermorphic NFKBIA mutations that result in reduced degradation of IκBα, present with multiple and severe bacterial, fungal and viral infections starting at an early age, typically before 3-months. cache = ./cache/cord-268843-zml9lbve.txt txt = ./txt/cord-268843-zml9lbve.txt === reduce.pl bib === id = cord-269087-f9hyntvf author = Li, X. title = A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19 date = 2020-04-04 pages = extension = .txt mime = text/plain words = 4280 sentences = 236 flesch = 49 summary = Results: We included 25 published literature references related to the epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. The risk factors which may suggest severe or critical progress for children are: Fast respiratory rate and/or; lethargy and drowsiness mental state and/or; lactate progressively increasing and/or; imaging showed bilateral or multi lobed infiltration, pleural effusion or rapidly expending of lesions in a short period of time and/or; less than 3 months old or those who underly diseases. To help better understand how it would affect children and what is the latest specific clinical and research finding on children with it, we provide a mini-review based on 25 literature references covering the fields of epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. According to the current literature on the pediatric cases, children confirmed with COVID-19 mostly had good prognosis, with considerably less severe to critical progress (5.9%) as compared to adult patients (18.5%). cache = ./cache/cord-269087-f9hyntvf.txt txt = ./txt/cord-269087-f9hyntvf.txt === reduce.pl bib === id = cord-268939-ws74xprt author = Ozoner, Baris title = Neurosurgery Practice During Coronavirus Disease 2019 (COVID-19) Pandemic date = 2020-05-28 pages = extension = .txt mime = text/plain words = 5138 sentences = 391 flesch = 46 summary = The increased burden has substantially impacted the neurosurgery practice and intensive modifications were required in surgical scheduling, inpatient and outpatient clinics, management of emergency cases, and even academic activities. Operations of COVID-19 positive patients, and emergency cases, where screening can not be obtained, should be performed following level 3 protective measures. [5] [6] [7] In neurosurgery practice, intensive modifications were required in surgical scheduling, administration of inpatient and outpatient clinics, management of emergency cases, and even academic & educational activities. 26 A recent study from Wuhan City, China reported that some severe COVID-19 patients developed neurologic manifestations, such as acute cerebrovascular diseases (5.7%), and impaired consciousness (14.8%). 76, 80 Also, a patient with a mass lesion in the sellar region that underwent endonasal endoscopic surgery in Neurosurgery Department, Tongji Medical College, Wuhan City, China was diagnosed with COVID-19 after surgery, and disease was confirmed in 14 healthcare professionals in the same clinic afterwards. cache = ./cache/cord-268939-ws74xprt.txt txt = ./txt/cord-268939-ws74xprt.txt === reduce.pl bib === id = cord-269031-sz8ieltb author = Solé, G title = Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network date = 2020-04-20 pages = extension = .txt mime = text/plain words = 5744 sentences = 245 flesch = 37 summary = Abstract In France, the epidemic phase of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in February 2020 and resulted in the implementation of emergency measures and a degradation in the organization of neuromuscular reference centers. In the context of NM diseases, particular attention must be paid to two experimental COVID-19 treatments, hydroxycholoroquine and azithromycin: risk of exacerbation of myasthenia gravis and QT prolongation in patients with pre-existing cardiac involvement. In France, the epidemic phase of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in February 2020 and resulted in the implementation of emergency measures and a degradation in the organization of neuromuscular reference centers. The main addressed topics pertain to the disease itself, its mode of transmission, the official national public health recommendations to prevent it, the behaviors to adopt in case symptoms appear, and its consequences specific to the neuromuscular patient (e.g., relating to the management of steroids and immunosuppressor treatments, medical appointments, rehabilitation, and 6 ventilation). cache = ./cache/cord-269031-sz8ieltb.txt txt = ./txt/cord-269031-sz8ieltb.txt === reduce.pl bib === id = cord-269280-1zbxjmxu author = Shao, Connie title = The COVID trolley dilemma date = 2020-05-14 pages = extension = .txt mime = text/plain words = 2900 sentences = 152 flesch = 59 summary = As the first wave of this pandemic subsides, hospital systems are faced with prioritizing which surgical services can resume while simultaneously minimizing the disruption of ongoing care for the remaining COVID-19 patients. Patients requiring oncologic surgery now face a "double jeopardy" of increased exposure to COVID-19 due to frequent interactions with medical facilities, but also worse outcomes associated with delaying surgery. As the immediate wave of morbidity and mortality associated directly with the COVID-19 pandemic subsides, the effects of delaying both diagnosis and surgery will be revealed. Guidelines, such as those created by ACS, for careful and precarious resumption of local "elective" surgeries are moot when conservation efforts are overrun by an uncontrolled Ro. At a time that we do not have herd immunity and a vaccine does not yet exist, government-mandated orders are necessary to protect our patients, ourselves, and those who will become our patients. cache = ./cache/cord-269280-1zbxjmxu.txt txt = ./txt/cord-269280-1zbxjmxu.txt === reduce.pl bib === id = cord-269099-q5nyzlhs author = Lee, Jisun title = Exploring the spatial arrangement of patient rooms for minimum nurse travel in hospital nursing units in Korea date = 2020-07-23 pages = extension = .txt mime = text/plain words = 7532 sentences = 357 flesch = 55 summary = The agent-based simulation was conducted to model nurses' walking trails, and the distance of one nurse travel to assigned patient rooms was measured for each nurse. The agent-based simulation was conducted to model nurses' walking trails, and the distance of one nurse travel to assigned patient rooms was measured for each nurse. With revisions in the spatial arrangement of patient rooms, locating multibed rooms near the nurse station, symmetric room layout centering the nurse station, and planning both single/double-bed and multi-bed rooms on one side of corridors, nurse travel distance decreased more than 15%. In the racetrack type units where single/double-bed and multi-bed rooms are located on the opposite sides of the floor (with the service core in the middle), nurses have to travel along both sides to care assigned patients. Among Korean inpatient unit case studies, Shin and Kang (2016) assessed nurse walking distances using traditional point-to-point linear measurement based on field interviews of nurses' patient room assignments. cache = ./cache/cord-269099-q5nyzlhs.txt txt = ./txt/cord-269099-q5nyzlhs.txt === reduce.pl bib === id = cord-269009-0i2bvt77 author = D’Souza, Rohan title = A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID‐19 date = 2020-08-05 pages = extension = .txt mime = text/plain words = 3295 sentences = 205 flesch = 36 summary = Should patients develop coronavirus disease (COVID‐19) pneumonia requiring hospital admission for treatment of hypoxia, the risk for thromboembolic complications increases greatly. 2 As pregnancy is a prothrombotic state, the possibility of an increased risk of thrombosis in pregnant women with COVID-19 has become an area of concern, and a number of international organiPatients with severe COVID-19 may be at risk for pulmonary thromboembolic complications through at least two distinct mechanisms -immunothrombosis and hospital-associated venous thromboembolism (VTE). 12 A recent study of patients with severe COVID-19 demonstrated a correlation between IL-6 and fibrinogen levels, 3 further supporting the theory that massive activation of the acute phase response, with increased production of coagulation factors, appears to be the predominant prothrombotic mechanism in COVID-19. A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID-19 cache = ./cache/cord-269009-0i2bvt77.txt txt = ./txt/cord-269009-0i2bvt77.txt === reduce.pl bib === id = cord-269564-r5mmsnbx author = Hans, Diana title = Rapidly Fatal Infections date = 2008-05-31 pages = extension = .txt mime = text/plain words = 7549 sentences = 426 flesch = 46 summary = Reports have suggested a mortality rate of 30% to 70% despite aggressive treatment [35] TSS is most commonly caused by Staphylococcus aureus and group A streptococcus. Unfortunately, complicated group A streptococcus infections are shown to have a high mortality rate despite aggressive antibiotic therapy, and penicillin has been shown to have limited effects if not initiated early in the disease. Fifty-three percent of the patients were positive for MRSA, and the risk factors associated with colonization included recent antibiotic use (within 3 months), hospitalization within the past year, skin or soft tissue infection on admission, and HIV infection [68] . PVL-positive S aureus pneumonia typically occurred in younger patients (median age, 14.8 years) who were previously healthy, and 75% were found to have had a viral infection in the preceding days. Two deadly viral infections that have emerged in recent years include severe acute respiratory syndrome (SARS) and influenza A (H5N1), also known as avian influenza or bird flu. cache = ./cache/cord-269564-r5mmsnbx.txt txt = ./txt/cord-269564-r5mmsnbx.txt === reduce.pl bib === id = cord-269289-6uog10j4 author = Mabillard, Holly title = Electrolyte Disturbances in SARS-CoV-2 Infection date = 2020-07-22 pages = extension = .txt mime = text/plain words = 5684 sentences = 289 flesch = 44 summary = These include additional respiratory complications (pulmonary fibrosis -reported in 21% of those hospitalised with SARS-CoV-2 9 months post-discharge in one study 3 ) 7 , cardiovascular complications (acute cardiac injury (7% 8 ), cardiomyopathy (1/3 patients 9 ), cardiac tamponade, heart failure, dysrhythmias (17% 8 ) and venous thromboembolic events (20% 10 )) 11 , neurological complications (myopathy, acute stroke (5.7% of those with severe infection 12 ), Guillain-Barre syndrome (0.4% hospitalised patients 11 ) and encephalopathy) 13 , acute liver and/or pancreatic injury (29% and 17% respectively in one cohort) 14 , cytokine storm syndrome, septic shock, DIC, diarrhoea, Kawasaki-like disease 14 and renal complications (acute tubular injury, rhabdomyolysis, proteinuria, secondary focal segmental glomerulosclerosis and possible renin-angiotensinaldosterone system activation) 15 . The study reported that the degree of hypokalaemia correlated with severity of SARS-CoV-2 symptoms and they suggested that hypokalaemia can be difficult to correct as seen in two patients because the renal potassium wasting persists until clinical recovery from the virus. cache = ./cache/cord-269289-6uog10j4.txt txt = ./txt/cord-269289-6uog10j4.txt === reduce.pl bib === id = cord-269190-w74bjtq1 author = Lennox, Angela M. title = Care of the Geriatric Rabbit date = 2010-02-11 pages = extension = .txt mime = text/plain words = 3434 sentences = 227 flesch = 43 summary = This article examines the spectrum of disease that can affect the geriatric rabbit as well as crucial factors concerning the clinical management of the animal up to the end of its life. Though designed for dogs and cats, the author and others have used this product in rabbits with chronic renal failure requiring longer-term at-home subcutaneous administration of fluid (see Hospice and end-oflife issues later in this article) (Fig. 1) . In some cases all teeth are eventually lost, and patients survive with good to excellent quality of life on a diet of liquid Critical Care (Oxbow Animal Health, Murdoch, NE). Causes are varied, and can include chronic renal failure and acquired dental disease. Use is not recommended in humans and tested animal patients that are dehydrated, or have liver or renal disease (due to reduction of blood flow to the kidneys). cache = ./cache/cord-269190-w74bjtq1.txt txt = ./txt/cord-269190-w74bjtq1.txt === reduce.pl bib === id = cord-269205-g6eyvnou author = Nilsen, Marci Lee title = Prevision of multidisciplinary head and neck cancer survivorship care during the 2019 novel coronavirus pandemic date = 2020-05-18 pages = extension = .txt mime = text/plain words = 3828 sentences = 186 flesch = 46 summary = These guidelines address five key areas: (a) surveillance for recurrence, (b) screening for second primary cancers, (c) assessment and management of physical and psychosocial effects of cancer and treatment, (d) health promotion, and (e) care coordination. Based on the PROs and patient assessment, the visit is personalized to provide an evaluation of recurrence, prevention of second primaries, identification of treatment-effects, and, subsequently, coordination of care. The COVID-19 pandemic has led to changes in medical oncology and radiation oncology care, including surveillance after completion of treatment, in an effort to still provide the care needed, but also reduce risks as much as possible. Prior to the COVID pandemic, our goal as a head and neck program has been to offer at least one visit with medical oncology and radiation oncology at the primary cancer center in order to help develop the plan and offer clinical trials if applicable for all patients. cache = ./cache/cord-269205-g6eyvnou.txt txt = ./txt/cord-269205-g6eyvnou.txt === reduce.pl bib === id = cord-269275-b7xxk48t author = Tang, Xiaojia title = Neurological manifestations in COVID-19 and its possible mechanism date = 2020-09-27 pages = extension = .txt mime = text/plain words = 4631 sentences = 260 flesch = 44 summary = SARS-CoV-2 has been reported to be associated with Guillain-Barré syndrome, rhabdomyolysis, acute cerebrovascular disease, central nervous system infections and other neurological diseases. Four formal reports have described neurological problems in SARS patients, including polyneuropathy [35] , myopathy and rhabdomyolysis [36] , large artery ischemic stroke [37] and central nervous system infections [38] . In a study by Mao et al., 214 patients diagnosed with COVID-19 were enrolled, and six (2.80%) of them developed acute cerebrovascular disease (five cases of ischemic stroke and one case of cerebral hemorrhage). Strokes are not uncommon in critically ill patients with multiple comorbidities, so SARS-CoV-2 infections in humans may increase the risk of stroke. Since some COVID-19 patients have complained of headaches, nausea etc, care providers should be alert for central nervous system infections caused by SARS-CoV-2 if such patients also exhibit symptoms such as a fever, epilepsy and disturbances of consciousness. cache = ./cache/cord-269275-b7xxk48t.txt txt = ./txt/cord-269275-b7xxk48t.txt === reduce.pl bib === id = cord-269105-yuphgyrn author = Dumantepe, Mert title = Subsegmental Thrombus in COVID-19 Pneumonia: Immunothrombosis or Pulmonary Embolism? Data Analysis of Hospitalised Patients With Coronavirus Disease date = 2020-08-24 pages = extension = .txt mime = text/plain words = 1324 sentences = 81 flesch = 38 summary = Thrombotic complications due to considerable inflammation, cytokine-mediated microvascular damage and pulmonary immunothrombosis formation seem to have emerged as an important issue in people infected with COVID-19. Cytokine-mediated microvascular damage, hypoxia, systemic inflammation, microangiopathy, coagulation pathway activation, and eventual immunothrombosis development have been described as key features of severe COVID-19 [4] . COVID-19 infection is related with high morbidity and mortality, mainly due to respiratory failure, with microvascular hyaline membrane and pulmonary immunothrombosis formation presumably playing a crucial role. In patients with COVID-19 pneumonia, presenting with disease progression or worsening of respiratory symptoms and significant elevation of D-Dimer levels, more attention should be paid to the occurrence of potential pulmonary embolism (PE) with or without deep venous thrombosis (DVT). During the study period, four COVID-19 pneumonia patients in conjunction with high-risk PE were treated with EKOS ™ Acoustic Pulse Thrombolysis ( [11] . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China cache = ./cache/cord-269105-yuphgyrn.txt txt = ./txt/cord-269105-yuphgyrn.txt === reduce.pl bib === id = cord-268974-7bqh1yas author = Capitelli-McMahon, Helen title = Characterising non-melanoma skin cancer undergoing surgical management during the COVID-19 pandemic date = 2020-11-02 pages = extension = .txt mime = text/plain words = 482 sentences = 29 flesch = 52 summary = title: Characterising non-melanoma skin cancer undergoing surgical management during the COVID-19 pandemic Our findings show that throughout the height of the COVID-19 pandemic our department saw significantly larger NMSC lesions, with a higher proportion of these being SCCs that required more complex reconstruction following excision. Larger, more invasive lesions may be likely to result in an increase in incomplete excision margins. Despite prioritisation of oncological services throughout the pandemic thus far, our findings show substantial differences in the patients accessing skin oncology services in our centre. It appears that current delays to definitive surgical treatment of smaller, less aggressive BCCs may mean patients are missing the opportunity to benefit from early excision of these lesions. Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic Global incidence of incomplete surgical excision in adult patients with non-melanoma skin cancer: study protocol for a systematic review and meta-analysis of observational studies cache = ./cache/cord-268974-7bqh1yas.txt txt = ./txt/cord-268974-7bqh1yas.txt === reduce.pl bib === id = cord-270019-er70ehk4 author = Yang, Kunyu title = Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study date = 2020-05-29 pages = extension = .txt mime = text/plain words = 4268 sentences = 242 flesch = 48 summary = title: Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study METHODS: We did a retrospective, multicentre, cohort study of 205 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and with a pathological diagnosis of a malignant tumour in nine hospitals within Hubei, China, from Jan 13 to March 18, 2020. Multivariable regression analysis showed that receiving chemotherapy within 4 weeks before symptom onset (odds ratio [OR] 3·51 [95% CI 1·16–10·59]; p=0·026) and male sex (OR 3·86 [95% CI 1·57–9·50]; p=0·0033) were risk factors for death during admission to hospital. 5 In particular, male sex and receiving chemotherapy within 4 weeks before symptom onset were identified as risk factors for death in patients with cancer who were diagnosed with COVID-19. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China cache = ./cache/cord-270019-er70ehk4.txt txt = ./txt/cord-270019-er70ehk4.txt === reduce.pl bib === id = cord-270079-vwnzp6zj author = Galanis, Nikiforos title = Coagulopathy in COVID-19 infection: a case of acute upper limb ischemia date = 2020-07-02 pages = extension = .txt mime = text/plain words = 1260 sentences = 70 flesch = 39 summary = We report a case of severe coagulopathy manifesting with right upper limb arterial and deep vein thrombosis in an 80-year-old male patient with severe COVID-19 associated pneumonia. At that point, his coagulation laboratory tests were deranged, and he eventually developed dry gangrene in his right thumb and index finger, as well as a deep venous thromboembolism in his right axillary vein. Since the beginning of the pandemic, it has become evident that COVID-19 infection does not only affect the respiratory tract but in some patients it seems to evolve to a systemic disease with severe complications such as acute respiratory distress syndrome (ARDS) and multi-organ failure [1] . We present a case of an 80-year-old patient with confirmed COVID-19 infection, who developed severe coagulopathy with peripheral arterial infarcts and deep venous thromboembolism. Seven days later, while his general condition was deteriorating, he developed acute ischemia in his right thumb and index finger (Fig. 2) . cache = ./cache/cord-270079-vwnzp6zj.txt txt = ./txt/cord-270079-vwnzp6zj.txt === reduce.pl bib === id = cord-269345-5tlyy8jp author = Minuz, Pietro title = High rate of pulmonary thromboembolism in patients with SARS-CoV-2 pneumonia date = 2020-06-18 pages = extension = .txt mime = text/plain words = 690 sentences = 46 flesch = 54 summary = Recently, thromboembolic events have been reported in 20/81 patients with severe SARS-CoV-2 32 pneumonia admitted to intensive care units (ICUs). In our case series, the involvement of segmental and subsegmental branches of the pulmonary 75 arteries along with the peculiar multiple and bilateral filling defects distribution, suggest a non-76 embolic origin of the pulmonary arteries thrombosis [4] . Compared to the rates previously reported in patients with pneumonia or other severe infections, a 81 higher prevalence of PTE in patients with SARS-CoV-2 pneumonia might be inferred from this 82 small series. The absence of major risk factors for thromboembolic events in 5 out of 6 patients 83 seems to further confirm the role of bilateral SARS-CoV-2 pneumonia as a risk factor for PTE. Prevalence of venous thromboembolism in patients with 119 severe novel coronavirus pneumonia cache = ./cache/cord-269345-5tlyy8jp.txt txt = ./txt/cord-269345-5tlyy8jp.txt === reduce.pl bib === id = cord-269425-e9iyso7n author = Bhattacharjee, Sukrita title = Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review date = 2020-09-19 pages = extension = .txt mime = text/plain words = 5418 sentences = 319 flesch = 46 summary = A systematic review was done to analyze the clinical profile and outcomes in a total of 45 cases of new-onset ITP in COVID-19 patients described in literature until date. Diagnosis of ITP in patients with moderate-to-severe COVID-19 poses a major diagnostic as well as therapeutic challenge to clinicians owing to presence of multiple concomitant conditions including HLH, DIC, sepsis, antibiotic use, heparin prophylaxis, and thromboembolic events. The following data were extracted from the included studies: age of the patient at presentation, gender, COVID-19 illness severity, comorbidities, medication use, nadir platelet count, onset of COVID-19 symptoms to diagnosis of ITP, bleeding manifestations of ITP, time to recovery from start of treatment, and clinical outcomes. Bone marrow study in these few selected cases of ITP would reveal low number of megakaryocytes, as seen in one patient of this review, who presented with severe thrombocytopenia (count 2 × 10 9 /μL) [7] . cache = ./cache/cord-269425-e9iyso7n.txt txt = ./txt/cord-269425-e9iyso7n.txt === reduce.pl bib === id = cord-269554-fzu6dy4e author = Hussein, M. H. title = Asthma in COVID-19: An extra chain fitting around the neck? date = 2020-07-15 pages = extension = .txt mime = text/plain words = 3091 sentences = 198 flesch = 51 summary = Univariate analysis of COVID-19 outcomes revealed that asthma was significantly associated with higher rate of endotracheal intubation (40.3% vs 27.8%, p = 0.036), mechanical ventilation (both invasive and non-invasive) (70.7% vs 52.2%, p = 0.039), and longer hospital length of stay (15.14 ± 12.48 days vs 11.51 ± 10.58 days, p = 0.015). Asthma was not associated with a higher rate of Intensive Care Unit (ICU) admission (22.2% vs 14.9%, p = 0.12), acute respiratory distress syndrome (37.5% vs 30.9%, p = 0.27), or death (9.7% vs 13.5%, p = 0.45) among COVID-19 patients. On comparison to non-asthmatic obese patients, obese asthmatic patients were more likely to develop sepsis (25.9% vs 14.2%, p = 0.042), had higher risk of ICU admission (48.1% vs 33.2%, p = 0.042), and required prolonged intubation (2.73 ± 3.63 days vs 1.38 ± 2.07, p = 0.032).Impact of asthma comorbidity on COVID-19 outcomes cache = ./cache/cord-269554-fzu6dy4e.txt txt = ./txt/cord-269554-fzu6dy4e.txt === reduce.pl bib === id = cord-269469-7pmnxi9a author = Bikdeli, Behnood title = Anticoagulation in COVID-19: Randomized trials should set the balance between excitement and evidence date = 2020-10-08 pages = extension = .txt mime = text/plain words = 1060 sentences = 72 flesch = 42 summary = [10] [11] [12] Such results were embraced by some clinicians and clinical institutions, leading to a change in their routine practice, including recommendations for escalated-dose prophylaxis in all, or some hospitalized patients with COVID-19. Multiple randomized trials have been registered and are at various stages of progress to identify the optimal antithrombotic therapy for outpatients, inpatients, and critically-ill patients with COVID-19. 18 In a pilot single-center study, the authors randomly The authors should be congratulated for completing the first randomized controlled trial of anticoagulant therapy in patients with COVID-19. Anticoagulation, Mortality, Bleeding and Pathology Among Patients Hospitalized with COVID-19: A Single Health System Study Intermediate versus Standard-dose Prophylactic anticoagulation and Statin Therapy versus Placebo in Critically-ill Patients with COVID-19: Rationale and Design of the INSPIRATION/ INSPIRATION-S Studies Anticoagulant interventions in hospitalized patients with COVID-19: A scoping review of randomized controlled trials and call for international collaboration Therapeutic versus prophylactic anticoagulation for severe COVID-19: a randomized phase II clinical trial (HESACOVID) cache = ./cache/cord-269469-7pmnxi9a.txt txt = ./txt/cord-269469-7pmnxi9a.txt === reduce.pl bib === id = cord-269690-6r2bfydw author = De Lorenzo, Rebecca title = Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study date = 2020-10-14 pages = extension = .txt mime = text/plain words = 4421 sentences = 245 flesch = 44 summary = Primary outcome was need of follow-up, defined as the presence at follow-up of at least one among: respiratory rate (RR) >20 breaths/min, uncontrolled blood pressure (BP) requiring therapeutic change, moderate to very severe dyspnoea, malnutrition, or new-onset cognitive impairment, according to validated scores. At regression tree analysis, the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO(2)/FiO(2)) and body mass index (BMI) at ED presentation, and age emerged as independent predictors of the need of follow-up. Demographical data (i.e. age, gender, and ethnicity), comorbidities (i.e. hypertension, HTN, coronary artery disease, CAD, diabetes mellitus, DM, chronic obstructive pulmonary disease, COPD, chronic kidney disease, CKD, active cancer, and current psychiatric disorder according to DSM-5), as well as body mass index (BMI), axillary body temperature, and laboratory values (i.e. the ratio of arterial oxygen partial pressure, PaO 2 in mmHg, to fractional inspired oxygen, FiO 2 , expressed as a fraction, PaO 2 /FiO 2 , white blood cell count, WBC, neutrophil to lymphocyte ratio, NLR, liver enzymes, lactate dehydrogenase, LDH, C-reactive protein, CRP, estimated glomerular filtration rate, eGFR using the CKD-EPI equation) at ED presentation were extracted for all patients. cache = ./cache/cord-269690-6r2bfydw.txt txt = ./txt/cord-269690-6r2bfydw.txt === reduce.pl bib === id = cord-269503-ij4u980v author = Amaratunga, Eluwana A title = Bradycardia in Patients With COVID-19: A Calm Before the Storm? date = 2020-06-13 pages = extension = .txt mime = text/plain words = 3493 sentences = 208 flesch = 44 summary = This is a retrospective case series of four patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to St. Luke's University Health Network ICU between 24 March 2020 and 5 April 2020. A study involving 138 patients infected with COVID-19 in Wuhan, China, demonstrated cardiogenic shock, arrhythmia, and acute cardiac injury to be among common complications; 8.7%, 16.7%, 7.2% respectively [1] . Patient demographics, comorbidities, presenting day of illness since symptom onset, admission heart rate, duration of illness at intubation, duration of illness at onset of bradycardia, vital signs [blood pressure, mean arterial pressure (MAP), oxygen saturation, respiratory rate, temperature], laboratory studies (including cTnI, ferritin, C-reactive protein, D-dimer, fibrinogen), as well as medications and dose adjustments were investigated and compared against episodes of bradycardia. As previously described, acute myocardial injury was thought to be the most common cardiac manifestation in COVID-19 patients and potential for developing cardiac arrhythmias has been noted in a few studies. cache = ./cache/cord-269503-ij4u980v.txt txt = ./txt/cord-269503-ij4u980v.txt === reduce.pl bib === id = cord-270294-g95skuik author = Johnstone, Jennie title = Viral Infection in Adults Hospitalized With Community-Acquired Pneumonia Prevalence, Pathogens, and Presentation date = 2008-12-31 pages = extension = .txt mime = text/plain words = 4441 sentences = 202 flesch = 43 summary = Furthermore, viral etiology studies in pneumonia are difficult to interpret as noninvasive viral detection methods are often considered to be only markers of infection rather than the cause of pneumonia." Clearly, much better knowledge of the potential role of respiratory viruses present in patients with pneumonia is needed. More recently, the introduction of highly sensitive nucleic acid amplification tests (NATs) has dramatically improved our ability to detect multiple viral pathogens such as influenza, respiratory syncytial virus (RSV), rhinovirus, parainfluenza, and adenovirus. [13] [14] [15] To date, there have been few studies, 5, 7, [9] [10] [11] 16 ,17 reported in patients with pneumonia using NATs to detect viral infection, and these studies have either not included clinical data 7.9.11 or have not tested for all potentially important respiratory viruses in a comprehensive manner.lv-!? cache = ./cache/cord-270294-g95skuik.txt txt = ./txt/cord-270294-g95skuik.txt === reduce.pl bib === id = cord-270509-roc93m4f author = Radhakrishnan, Suma title = Guidelines for Surgical Tracheostomy and Tracheostomy Tube Change During the COVID-19 Pandemic: A Review Article date = 2020-06-22 pages = extension = .txt mime = text/plain words = 1523 sentences = 138 flesch = 53 summary = We also did explore the current literature and recommendations for tracheostomy in patients with COVID-19 and studied the previous data from severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), the virus responsible for the SARS outbreak of 2003. • The benefit of performing early tracheostomy in critically ill COVID-19 patients are unclear from available data [1] . • To reduce time in contact with aerosolized secretionscomplete paralysis of patient to prevent coughing; stopping mechanical ventilation just before entering trachea; reducing use of suction during the procedure [14] . 4. Tracheotomy is performed under direct vision without movement of patient; tracheostomy tube is inserted, followed by inflation of the balloon. Effect of early versus late or no tracheostomy on mortality and pneumonia of critically ill patients receiving mechanical ventilation: a systematic review and metaanalysis Surgical considerations for tracheostomy during the COVID-19 pandemic: lessons learned from the severe acute respiratory syndrome outbreak cache = ./cache/cord-270509-roc93m4f.txt txt = ./txt/cord-270509-roc93m4f.txt === reduce.pl bib === id = cord-270153-krhkqcev author = Khosla, Seema title = Implementation of Synchronous Telemedicine into Clinical Practice date = 2020-08-04 pages = extension = .txt mime = text/plain words = 5447 sentences = 365 flesch = 61 summary = Synchronous telemedicine allows clinicians to expand their reach by using technology to take care of patients who otherwise may not be seen. If the clinician is planning to transition current in-person patients to a telemedicine model, or if it has been determined that there is room in the clinic schedule, the next step is to assess the financial feasibility of a telemedicine practice. It is vital to take the time to create an appropriate clinical experience for both the patient and the clinician, which involves setting up the environment and paying attention to specific details that will allow the clinician to execute a successful telemedicine encounter. 26 Clinicians are able to reach patients who would otherwise never be seen by using telemedicine technology. Many of these health care consumers also expect to be able to have a face-to-face visit with their clinicians on demand in the convenience of their homes or places of work. cache = ./cache/cord-270153-krhkqcev.txt txt = ./txt/cord-270153-krhkqcev.txt === reduce.pl bib === id = cord-269591-lu415jcp author = nan title = Recommendations Regarding COVID19 Infection in Rheumatic Patients in Greece date = 2020-03-31 pages = extension = .txt mime = text/plain words = 835 sentences = 55 flesch = 41 summary = authors: nan Based on the above limited data, our National Society, taking into account the critical situation with the COVID19 infection worldwide and the potential risk for severe disease in our patients: Although the World Health Organisation (WHO), 6 the National Organisation of Public Health in Greece (https:// eody.gov.gr/covid-19-odigies-therapeias/) and experts in the field 7 do not recommend glucocorticoids (GCs) in patients with severe COVID19 infection, in a recent retrospective study from China, administration of methylprednisolone in patients with acute respiratory distress syndrome (ARDS) resulted in a significant reduction in mortality (from 62% to 46%, Hazard Ratio = 0.38). WHO: Clinical Management Of Severe Acute Respiratory Infection (SARI) When COVID-19 Disease Is Suspected. Risk Factors Associated With Acute Respiratory Distress Syndrome And Death In Patients With Coronavirus Disease 2019 Pneumonia In Wuhan, China cache = ./cache/cord-269591-lu415jcp.txt txt = ./txt/cord-269591-lu415jcp.txt === reduce.pl bib === id = cord-270348-5804ffwx author = Angelino, Andrew F. title = Design and implementation of a regional inpatient psychiatry unit for asymptomatic SARS-CoV-2 positive patients. date = 2020-07-02 pages = extension = .txt mime = text/plain words = 5818 sentences = 334 flesch = 59 summary = To prevent COVID-19 outbreaks in our units, we next decided to require universal nasal swab testing for SARS-CoV-2 for all medically asymptomatic patients being admitted to psychiatric units 3 . Second, we realized that we needed to decide where to care for SARS-CoV-2 positive, medically asymptomatic patients with mental illnesses who required hospitalization-those without symptoms of COVID-19. In light of the above, we concluded it would best serve our patients if we developed an inpatient psychiatric unit capable of accepting SARS-CoV-2 infected patients without COVID-19 symptoms, or with mild enough symptoms that they would not require medical hospitalization. Further, it is highly beneficial for continuity of care if the patient requires transfer to a medical COVID-19 unit that the psychiatrist be able to follow them there and maintain the psychiatric treatments as indicated. cache = ./cache/cord-270348-5804ffwx.txt txt = ./txt/cord-270348-5804ffwx.txt === reduce.pl bib === id = cord-266713-rghowch1 author = Reyes-Bueno, JA title = Case fatality of COVID-19 in patients with neurodegenerative dementia date = 2020-10-07 pages = extension = .txt mime = text/plain words = 2799 sentences = 181 flesch = 52 summary = DISCUSSION Our results suggest that case fatality of COVID-19 is significantly higher among patients with primary degenerative dementia than in other patients with similar mean ages and comorbidities. S a m p l e c h a r a c t e r i s t i c s COVID-19 was diagnosed according to the classification of the Spanish Ministry of Health: confirmed cases (patients with positive RT-PCR results for SARS-CoV-2) and probable cases (patients with a severe acute respiratory infection requiring hospitalisation and with clinical and radiological characteristics compatible with COVID-19, in the absence of RT-PCR confirmation). 13 These results are similar to our own: we found a COVID-19-associated case fatality rate of 43.4% in patients with dementia; this was significantly higher than the rate in the control group. Heart diseases were more prevalent in the group of patients with primary degenerative dementia, and were associated with a statistically significant increase in the mortality rate. Our study suggests that the case fatality of COVID-19 is significantly higher in patients with primary degenerative dementia than among other patients with similar ages and comorbidities. cache = ./cache/cord-266713-rghowch1.txt txt = ./txt/cord-266713-rghowch1.txt === reduce.pl bib === id = cord-269981-xm0by310 author = Shen, Cheng title = Perioperative preparation in thoracic day surgery: Battle against COVID‐19 date = 2020-06-17 pages = extension = .txt mime = text/plain words = 1662 sentences = 90 flesch = 48 summary = The day surgery center of West China Hospital is a hospital-based surgical setting that has nine operating rooms, a post-anesthesia care unit (PACU), 33 beds, and two nurse stations. Patients have to visit appropriate specialist clinics to evaluate whether they qualify for thoracic day surgery. In this scenario, patients must complete a thoracic specialist clinic evaluation and a COVID-19 epidemic survey. For the first time, patients must bring all their test results and anesthesia consultation to the Day Surgery Appointment Center for the surgeon to review and confirm whether all the tests have been completed prior to surgery. Generally, postoperative patients will transfer to the day surgery center ward after PACU for stage II recovery. To our knowledge, our data provide the first direct program and clinical pathway for thoracic day surgery to prevent the spread of COVID-19. cache = ./cache/cord-269981-xm0by310.txt txt = ./txt/cord-269981-xm0by310.txt === reduce.pl bib === id = cord-270124-tqhkzd2w author = Campos, Fábio Guilherme title = General recommendations to the colorectal surgeon during the COVID-19 pandemic date = 2020-06-19 pages = extension = .txt mime = text/plain words = 2196 sentences = 123 flesch = 46 summary = The present article aimed to bring to the colorectal surgeon the current recommendations and general safety measures in order to prevent infection dissemination, to improve surgical planning in terms of timing and specific technical aspects. Since its appearance in China, in December of last year, the infection J o u r n a l P r e -p r o o f caused by the new coronavirus, SARS-CoV-2 (known as COVID-19), has spread rapidly and was declared a pandemic by the World Health Organization (WHO) in March of this year. While there is an increasing number of new cases and deaths, there is a recommendation to delay elective surgeries (including selected cancer cases) in order to provide medical resources and beds (including ICUs), increase the hospital areas that can be used, concentrate hospital activities for emergency care and, mainly, reduce the chances of cross-infection of doctors, patients and visitors. [15] General recommendations and care measures during surgical procedures Any procedure performed on a COVID-19-positive or suspected patient must be performed in a specific room. cache = ./cache/cord-270124-tqhkzd2w.txt txt = ./txt/cord-270124-tqhkzd2w.txt === reduce.pl bib === id = cord-270210-gfy2ytg5 author = Drent, Marjolein title = Benefit of Wearing an Activity Tracker in Sarcoidosis date = 2020-08-22 pages = extension = .txt mime = text/plain words = 4444 sentences = 243 flesch = 51 summary = The aim of this study was to estimate the effect of continuous activity monitoring using an electronic activity tracker (AT) on exercise performance and fatigue of sarcoidosis patients, compared to controls (cohort study), and the effect of additional personal coaching (randomized trial) over a period of 3 months. Exercise performance of patients wearing an AT (Group I) improved compared with controls (Group II), including the 6MWD, % predicted (∆4.4 ± 9.1 versus ∆0.7 ± 5.0, respectively), and fatigue levels decreased (∆−3.9 ± 5.7 versus ∆−1.8 ± 5.3). The aim of this study was to estimate (1) the potential effect of continuous activity monitoring using an electronic AT, compared with a historical control group in a cohort study and (2) the effect of additional personal coaching of sarcoidosis patients in a randomized trial. Wearing an AT in general, even without personal coaching by a physical therapist, improved exercise capacity and reduced fatigue in sarcoidosis patients. cache = ./cache/cord-270210-gfy2ytg5.txt txt = ./txt/cord-270210-gfy2ytg5.txt === reduce.pl bib === id = cord-270327-v4td3zsa author = Atallah, Bassam title = A Marker of Systemic Inflammation or Direct Cardiac Injury: Should Cardiac Troponin Levels be Monitored in COVID-19 Patients? date = 2020-04-29 pages = extension = .txt mime = text/plain words = 1691 sentences = 95 flesch = 47 summary = The first and perhaps most significant overlap between COVID-19 and cardiac disease lies in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)'s pathogenicity and virulence. Of this cohort, 19.7% of patients had cardiac injury, accompanied by more comorbidities, and higher levels of C-reactive protein (CRP), procalcitonin, creatine kinasemyocardial band (MB fraction), myoglobin, high-sensitivity troponin I (hs-cTnI), N-terminal pro-B-type natriuretic peptide (NT-proBNP), aspartate aminotransferase (AST) and creatinine. 5 With relation to COVID-19, a meta-analyses of four studies that included a total of 341 patients in China found the values of cTnI to be significantly increased in cases of severe disease (SMD, 25.6 ng/L; 95% CI, 6.8-44.5 ng/L) compared to milder forms. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres. cache = ./cache/cord-270327-v4td3zsa.txt txt = ./txt/cord-270327-v4td3zsa.txt === reduce.pl bib === id = cord-270525-nmebqrb1 author = Núñez-Velasco, Santiago title = Response to SARS-CoV-2 Pandemic in a Non-COVID-19 Designated Latin-American Neurosurgery Department date = 2020-05-11 pages = extension = .txt mime = text/plain words = 2660 sentences = 133 flesch = 53 summary = METHODS An organized response regarding personnel, surgical case selection, operating room behavior, and facility reorganization were designed to prevent an internal coronavirus outbreak in the neurosurgery department at the Fray Antonio Alcalde Civil Hospital of Guadalajara. Based on the epidemiological and biological information available in the literature on COVID-19, specific measures adapted to our resources were implemented to design a protocol of organized administration of human resources both assistant and administrative, optimized surgical procedures, proper handling of personal protective equipment and adaptation of the facilities of the neurosurgery department of the FAAHC when treating neurosurgical patients with no SARS-CoV-2 known condition. This would lead us to a catastrophic scenario because there are reports of a 12% of hospital-associated transmission of the virus as the mechanism of infection of patients, that in our case are weak and many of them immunosuppressed; thus, cases of contamination of health-care personnel have also been reported, especially in non-designated COVID areas in which precautions might relax. cache = ./cache/cord-270525-nmebqrb1.txt txt = ./txt/cord-270525-nmebqrb1.txt === reduce.pl bib === id = cord-270391-703js942 author = Rai, Harpreet K title = Atypical Presentation of Panhypopituitarism date = 2020-07-09 pages = extension = .txt mime = text/plain words = 1699 sentences = 116 flesch = 41 summary = Additional workup showed a deficiency of all the anterior pituitary hormones likely secondary to mass effect. Pituitary apoplexy, for example, presents with the rapid development of symptoms causing sudden impairment of adrenocorticotropic hormone (ACTH) secretion and, consequently, the sudden onset of cortisol deficiency symptoms. We describe a patient who presented following a syncopal episode with a wide range of differential diagnoses based on initial laboratory results, clinical course, and workup, ultimately leading to the diagnosis of panhypopituitarism. 2020 The patient was discharged with recommendations for outpatient follow-up with the endocrinology team for continued monitoring of his pituitary hormone level deficiencies and sellar mass. Patients admitted to the hospital for further workup of syncope usually undergo an extensive cardiac and neurological assessment. The patient presented above was diagnosed with a sellar mass leading to hyposecretion of all the pituitary hormones. Postural hypotension and syncope are the most common presentations of secondary adrenal insufficiency and panhypopituitarism. cache = ./cache/cord-270391-703js942.txt txt = ./txt/cord-270391-703js942.txt === reduce.pl bib === id = cord-269835-mz7i66qp author = Furfaro, Federica title = SFED recommendations for IBD endoscopy during COVID-19 pandemic: Italian and French experience date = 2020-06-11 pages = extension = .txt mime = text/plain words = 7275 sentences = 295 flesch = 38 summary = The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has required a complete change in the management of patients with inflammatory bowel disease (IBD) who need to undergo endoscopic procedures. In particular, recommendations regarding the use of personal protective equipment to prevent COVID-19 transmission, both for patients and health-care professionals, are proposed and different scenarios in endoscopic IBD management are evaluated to suggest when endoscopy could be rescheduled and replaced by alternative biomarkers. The panel of experts con sidered possible aerosolization during colonoscopy, in particular during the insertion and removal of instruments through the biopsy channel and the presence of the virus in the stool and advised on the use of N95 masks for lower gastrointestinal procedures as a precautionary measure to protect the endoscopist from the risk of possible COVID-19 transmission from the patient if infected by SARS-CoV-2 (ref. cache = ./cache/cord-269835-mz7i66qp.txt txt = ./txt/cord-269835-mz7i66qp.txt === reduce.pl bib === id = cord-270388-nozh463l author = Damiani, M. title = Extracorporeal Cytokine Hemadsorption in Severe COVID-19 Respiratory Failure date = 2020-06-29 pages = extension = .txt mime = text/plain words = 1051 sentences = 73 flesch = 53 summary = Despite the extracorporeal cytokine hemadsorption device CytoSorb was granted FDA emergency approval for critically ill COVID19 patients, to our knowledge no published studies are currently available to support its use. 4 An alternative treatment able to reduce circulating cytokines in critically ill patients is CytoSorb (Aferetica srl, Italy), a device containing adsorbent polymer beads designed to irreversibly remove cytokines currently used for septic shock and other conditions where elevated levels of cytokines are present. Despite the lack of published results, based on bench performance testing and reported clinical experience, CytoSorb was granted FDA emergency approval for critically ill SARS-CoV-2 patients on April 10, 2020. . https://doi.org/10.1101/2020.06.28.20133561 doi: medRxiv preprint C-reactive protein (CRP) levels and respiratory parameters including the PaO2/FiO2 ratio (P/F) were assessed daily. Further studies are required to assess if CytoSorb can improve the clinical outcome of critically ill patients. cache = ./cache/cord-270388-nozh463l.txt txt = ./txt/cord-270388-nozh463l.txt === reduce.pl bib === id = cord-269511-bfd1dmt3 author = Salacup, Grace title = Characteristics and Clinical Outcomes of COVID‐19 Patients in an Underserved‐Inner City Population: A Single Tertiary Center Cohort date = 2020-07-03 pages = extension = .txt mime = text/plain words = 3453 sentences = 229 flesch = 51 summary = Multivariate logistic regression was Accepted Article used to look at the factors associated with inpatient mortality as primary outcome, and need for vasopressors, CRRT/HD, and mechanical ventilation as secondary outcomes. In this retrospective single center study, clinical characteristics were described, and risks factors were determined in association with inpatient death, need for intubation, need for CRRT/HD, and vasopressor use among hospitalized COVID-19 patients in an underserved minority population. Multivariate regression analysis showed that age as a continuous variable is significantly associated with inpatient mortality (p<0.001) with mean age higher amongst patient who died compared to those who survived (73 years old vs 64 years old; p<0.0001). Although African American patients, who were 70% of our study population, tended to have higher rates of obesity, hypertension, and diabetes, there were no significant difference compared to other races (see Table S2 ). Patients in this study who received COVID-19 specific treatment (steroid, tocilizumab, and hydroxychloroquine) had poor clinical outcomes. cache = ./cache/cord-269511-bfd1dmt3.txt txt = ./txt/cord-269511-bfd1dmt3.txt === reduce.pl bib === id = cord-269776-hj1s3ipp author = Agostoni, Angelo title = Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond date = 2004-09-11 pages = extension = .txt mime = text/plain words = 49824 sentences = 2688 flesch = 44 summary = Concerning HAE-I and HAE-II, just as variations in serum concentrations of APP appear to determine which individuals in a normal population develop angioedema with a second perturbation of kinin metabolism, such as the use of ACE inhibitors, 96 it could be speculated that variations in either kinin activation or inactivation pathways might contribute to the differences in severity of angioedema in individuals with a pre-existing perturbation in kinin metabolism, such as a mutation in C1-INH (as occurs in HAE). 13, 14, 27 This increase in plasma bradykinin was demonstrated both for patients with HAE with C1-INH deficiency and for patients with drug-associated angioedema who had an angioedematous attack in conjunction with ACE inhibitor treatment. The patient's daughter had recurrent skin angioedema and gastrointestinal pain attacks since age 12 years; therefore, with a normal C1-INH concentration and activity in both mother and daughter, a diagnosis of HAE type III was assumed. cache = ./cache/cord-269776-hj1s3ipp.txt txt = ./txt/cord-269776-hj1s3ipp.txt === reduce.pl bib === id = cord-270712-v6nnnzhm author = Woodcock, J. A. title = Test, test, test! date = 2020-06-26 pages = extension = .txt mime = text/plain words = 1678 sentences = 101 flesch = 60 summary = patients' general medical practitioners (GMPs), funding restraints have resulted in NHS Clinical Commissioners advising against the routine prescription of high fluoride toothpaste in primary medical settings. For oncology patients without a regular GDP, or those who may have intermittent treatment in a tertiary dental centre, accessing prescriptions for high fluoride products may be particularly challenging during COVID-19. Sir, there are two reasons why the current guidelines pose an existential risk to dental practice: • The additional costs involved plus the required fallow periods make general practice dentistry unsustainable • The necessity to approach our patients while dressed like Darth Vader will raise perceived levels of fear and panic among them. It is important to reflect that we have always been an infection aware profession and have therefore often been at the forefront of infection control in the surgery for both our patients and the whole dental team. cache = ./cache/cord-270712-v6nnnzhm.txt txt = ./txt/cord-270712-v6nnnzhm.txt === reduce.pl bib === id = cord-270776-oulnk1b3 author = Chau, Tai-nin title = Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome date = 2004-08-15 pages = extension = .txt mime = text/plain words = 2775 sentences = 142 flesch = 45 summary = title: Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome Purpose To determine whether the initial chest radiograph is helpful in predicting the clinical outcome of patients with severe acute respiratory syndrome (SARS). Results Bilateral disease and involvement of more than two zones on the initial chest radiograph were associated with a higher risk of liver impairment and poor clinical outcome. Together with the clinical characteristics of SARS, such as fever and chest symptoms, and a recent history of contact with a suspected or confirmed SARS patient, radiographic evidence of infiltrates consistent with pneumonia or acute respiratory distress syndrome is important in establishing the diagnosis (5) . Studies involving patients with community-acquired pneumonia (10) , acute interstitial pneumonia (11) , or idiopathic pulmonary fibrosis (12) have shown that quantitative and qualitative changes on chest radiographs might predict clinical outcome. cache = ./cache/cord-270776-oulnk1b3.txt txt = ./txt/cord-270776-oulnk1b3.txt === reduce.pl bib === id = cord-270665-z4l3lq39 author = Tian, Qing title = Endoscopic mask innovation and protective measures changes during the COVID‐19 pandemic: experience from a Chinese hepato‐biliary‐pancreatic unit date = 2020-07-23 pages = extension = .txt mime = text/plain words = 1833 sentences = 115 flesch = 44 summary = However, due to the distinctive epidemiological characteristics of SARS‐CoV‐2 (the virus causing COVID‐19), healthcare providers are exposed to the patient's respiratory and gastrointestinal fluids, rendering endoscopy a high risk for transmitting a nosocomial infection. This article introduces preventive measures for endoscopic treatment enacted in our medical center during COVID‐19, including the adjustment of indications, the application of endoscope protective equipment, the design and application of endoscopic masks and splash‐proof films, and novel recommendations for bedside endoscope pre‐sterilization. During the COVID-19 pandemic, due to the distinctive epidemiological characteristics of SARS-CoV-2, endoscopy poses a high risk of nosocomial infection, since healthcare providers are exposed to the patient's respiratory and gastrointestinal fluids 6 . 6) All medical personnel who a) have fever or respiratory symptoms, b) had contact with suspected or confirmed COVID-19 patients, c) live in or had contact with individuals residing in areas where the disease is prevalent, or d) recently returned from a high-pandemic area or country should undergo self-isolation for 14 days. cache = ./cache/cord-270665-z4l3lq39.txt txt = ./txt/cord-270665-z4l3lq39.txt === reduce.pl bib === id = cord-270654-cz2y6ta9 author = Deftereos, Spyridon G. title = The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design date = 2020-04-03 pages = extension = .txt mime = text/plain words = 2114 sentences = 136 flesch = 43 summary = Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. Based on the aforementioned data, the question which arises is whether colchicine, administered in a relatively low dose, could potentially have an effect the patients' clinical course by limiting the myocardial necrosis and pneumonia development in the context of COVID-19. Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation cache = ./cache/cord-270654-cz2y6ta9.txt txt = ./txt/cord-270654-cz2y6ta9.txt === reduce.pl bib === id = cord-271603-zy4l9vtf author = Skali, Hicham title = Guidance and Best Practices for Reestablishment of Non-Emergent Care in Nuclear Cardiology Laboratories During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Information Statement from ASNC, IAEA, and SNMMI date = 2020-10-17 pages = extension = .txt mime = text/plain words = 3726 sentences = 206 flesch = 42 summary = title: Guidance and Best Practices for Reestablishment of Non-Emergent Care in Nuclear Cardiology Laboratories During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Information Statement from ASNC, IAEA, and SNMMI • For SPECT myocardial perfusion imaging studies in inpatients who are not eligible for stress only testing, consider performing the rest injection in the patient's inpatient room, to avoid completely or minimize waiting time in the laboratory. The nuclear cardiology laboratory's protocols and patient scheduling templates will need to be closely monitored and refined multiple times over the coming months as the COVID-19 pandemic slowly recedes, with potential for local or widespread waves of new COVID-19 infections. • Providers and institutions should monitor local data and follow national, state, and department of public health recommendations for possible second COVID-19 waves that may require decreasing nuclear cardiology laboratory activities and enhanced protective measures. cache = ./cache/cord-271603-zy4l9vtf.txt txt = ./txt/cord-271603-zy4l9vtf.txt === reduce.pl bib === id = cord-270245-zziwb2jy author = Russell, Beth title = Factors Affecting COVID-19 Outcomes in Cancer Patients: A First Report From Guy's Cancer Center in London date = 2020-07-22 pages = extension = .txt mime = text/plain words = 4112 sentences = 192 flesch = 47 summary = Being of Asian ethnicity [3.73 (1.28–10.91)], receiving palliative treatment [5.74 (1.15–28.79)], having an initial cancer diagnosis >24 months before [2.14 (1.04–4.44)], dyspnea [4.94 (1.99–12.25)], and increased CRP levels [10.35 (1.05–52.21)] were positively associated with COVID-19 death. During a median follow-up of 37 days, the following cancer patient characteristics were found to be positively associated with COVID-19 death: Asian ethnicity, palliative treatment, initial cancer diagnosis >24 months, dyspnea at presentation, and high CRP levels. Apart from the CCC-19 Consortium (16) , no study to date has specifically looked at COVID-19 severity at presentation in COVID-19 positive cancer patients and hence our observation of an association with time since cancer diagnosis and presenting symptoms needs further validation in other large cohorts with homogenous definitions of inclusion criteria, testing strategies, and outcome measures. cache = ./cache/cord-270245-zziwb2jy.txt txt = ./txt/cord-270245-zziwb2jy.txt === reduce.pl bib === id = cord-270723-cjfglili author = Fteiha, Bashar title = QTc prolongation among hydroxychloroquine sulfate‐treated COVID‐19 patients: An observational study date = 2020-10-15 pages = extension = .txt mime = text/plain words = 3317 sentences = 191 flesch = 50 summary = Age > 65 years, congestive heart failure, severity of disease, C‐reactive protein level, hypokalemia and furosemide treatment, were all associated with QTc prolongation. CONCLUSION: In patients treated with HCQ, QTc prolongation was associated with the presence of traditional risk factors such as hypokalemia and furosemide treatment. All rights reserved Univariate analysis revealed that in COVID-19 patients treated with HCQ, age above 65 years, severe or critical illness, congestive heart failure, hypokalemia, furosemide treatment and increased CRP level were all significantly associated with the composite endpoint (Table 2) . However, multivariate analysis in this small dataset also suggested that in COVID-19 patients treated with HCQ, concomitant hypokalemia and furosemide treatment were strongly associated with QTc prolongation. In conclusion, our study shows that QTc prolongation among HCQ-treated patients was associated with traditional, modifiable risk factors such as hypokalemia and furosemide treatment which are both commonly observed in COVID-19 patients. cache = ./cache/cord-270723-cjfglili.txt txt = ./txt/cord-270723-cjfglili.txt === reduce.pl bib === id = cord-270763-idkylpb6 author = Fontes, Cristina Asvolinsque Pantaleão title = Influenza A virus H1N1 associated pneumonia - acute and late aspects evaluated with high resolution tomography in hospitalized patients date = 2020-09-30 pages = extension = .txt mime = text/plain words = 3927 sentences = 193 flesch = 45 summary = The purpose of this study was to review the acute and late phase pulmonary findings in influenza A(H1N1) associated pneumonia using high resolution computed tomography (HRCT), and to determine the importance of performing end expiration series. RESULTS: Ground glass opacities, consolidations, and the combination of both were associated with the acute phase, whereas persistence or worsening of the lesions, lesion improvement, and air trapping in the end expiration series (as seen using HRCT, n=6) were observed in the late phase. In this study, the findings were divided according to the acute and late (10 days to 4 months after first onset of respiratory symptoms) phases of the disease, in patients with persistent pulmonary complaints. The images obtained in our study in patients with influenza A (H1N1) pneumonia included areas of consolidation and/or ground glass opacities, unilateral or bilateral findings, and predominated at the periphery of the lungs. cache = ./cache/cord-270763-idkylpb6.txt txt = ./txt/cord-270763-idkylpb6.txt === reduce.pl bib === id = cord-270876-kul6bs3w author = Morris, Nathaniel P. title = Virtual Visits and the Future of No-Shows date = 2020-06-08 pages = extension = .txt mime = text/plain words = 1301 sentences = 71 flesch = 53 summary = 2 By allowing patients to remotely attend appointments through audiovisual applications, virtual visits bring promise for decreasing outpatient no-shows. Patients can attend virtual visits from anywhere, including their homes, their workplaces, or even their parked cars, decreasing the burdens of making it to in-person appointments. In the study of general surgery outpatients from 2018, 123 (55%) of 223 patients reported they would prefer in-person appointments over virtual ones, even when accounting for the time and cost of coming to in-person appointments. 2 Patients and clinicians might struggle with setting up the technology needed for virtual visits, which might waste time and resources. For example, a 2019 study from Canada of home virtual visits for 75 patients at a stroke prevention clinic reported a no-show rate of 2 (3%) out of 81 appointments, but the study did not include comparisons of no-show rates for in-person clinic visits. Why do patients miss their appointments at primary care clinics? cache = ./cache/cord-270876-kul6bs3w.txt txt = ./txt/cord-270876-kul6bs3w.txt === reduce.pl bib === id = cord-270740-3su8pc3f author = Sultan, Sherif title = COVID-19 Cytokine Storm and Novel Truth date = 2020-05-22 pages = extension = .txt mime = text/plain words = 2381 sentences = 140 flesch = 56 summary = A Chinese scientist(5) used a bio-informatics model to describe the hypothesis of COVID 19 as methemoglobin, where the COVID-19 virus structural protein sticks to heme -displaces oxygen -which alters the iron-free ion, leading to inflammation of alveolar macrophages, which culminate in a systemic response ending in a cytokine storm . What we must focus on is that COVID19 attacks RBCs. Patients have frequently been found COVID-19, SARS2 is not 'pneumonia' nor ARDS Through the current experience across the world, invasive ventilation is becoming the last resort, as emergency intubation from the Chinese, Italian and American experience evidences higher mortality, not to mention complications from tracheal scarring and stiff lung during the duration of intubation. The lung damage seen on CT scans is due to the oxidative stress released from the hemolysed red blood cells, which in turn overwhelm the natural defenses against pulmonary oxidative stress and cause a cytokine storm. cache = ./cache/cord-270740-3su8pc3f.txt txt = ./txt/cord-270740-3su8pc3f.txt === reduce.pl bib === id = cord-270933-ecmg8kti author = Ali, Ashaq title = COVID-19: Clinical aspects and therapeutics responses date = 2020-07-03 pages = extension = .txt mime = text/plain words = 1655 sentences = 102 flesch = 51 summary = Furthermore our newly applied combination (Lianhuaqingwen and Arbidol Hydrochloride) showed effects in 5-7 days for patients with mild symptoms and was found effective with 98 % recovery rate. The significant alternation in laboratory findings during hospitalization was a high level of C reactive protein, lymphopenia, increases in WBC, and neutrophil count ( Both patients with mild symptoms and asymptomatic, received TCM LH Capsule in combination with Arbidol Hydrochloride tablets, with dosage and duration detail in (Table 03 ). Findings of the current study have shown that the treatment of COVID-19 patients with LH capsule in combination with Arbidol Hydrochloride resulted in significant recovery. Furthermore, the combination of LH with Aribidol hydrochloride can be used as effective therapeutics against COVID-19, specifically for Patients with mild symptoms. The effect of Arbidol Hydrochloride on reducing mortality of Covid-19 patients: a retrospective study of real world date from three hospitals in Wuhan cache = ./cache/cord-270933-ecmg8kti.txt txt = ./txt/cord-270933-ecmg8kti.txt === reduce.pl bib === id = cord-271358-5666nsb9 author = Roncon, Loris title = Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date = 2020-05-06 pages = extension = .txt mime = text/plain words = 420 sentences = 33 flesch = 47 summary = authors: Roncon, Loris; Zuin, Marco; Rigatelli, Gianluca title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment Doubtless this is a very important issue in the management of COVID-19 patients, but can heparin be administered in all cases? Should we consider a dose reduction in those patients with a severe thrombocytopenia? In this regard, it is would be important also to establish different anticoagulant strategies in COVID-19 patients with thrombocytopenia which is frequently observed in clinical practice. This article does not contain any studies with human participants performed by any of the authors. Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis Thrombocytopenia and its association with mortality in patients with COVID-19 Loris Roncon and Marco Zuin are equally contributed to the manuscript as first author cache = ./cache/cord-271358-5666nsb9.txt txt = ./txt/cord-271358-5666nsb9.txt === reduce.pl bib === id = cord-271180-cnrs0zpg author = Rizvi, Saniya title = Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date = 2020-09-18 pages = extension = .txt mime = text/plain words = 3896 sentences = 220 flesch = 49 summary = CytosorbentsⓇ cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. The following is a case report on a patient encounter and management course through the course of illness in which the Cytosorbents Ⓡ filter was used for his presentation of COVID-19 with severe ARDS, worsening renal dysfunction and evidence of evolving cytokine storm. Chest x-ray hospital day 16, 5 days after the initiation of cytokine filter when the patient developed worsening hypoxia and increased oxygen requirements as indicated in Table 2 below. cache = ./cache/cord-271180-cnrs0zpg.txt txt = ./txt/cord-271180-cnrs0zpg.txt === reduce.pl bib === id = cord-271149-qnhlfozo author = Huo, Xiang title = Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014 date = 2016-09-01 pages = extension = .txt mime = text/plain words = 3679 sentences = 193 flesch = 46 summary = Disease severity, proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient's direct medical cost of hospitalization. The mean direct cost of hospitalization with H7N9 (US$ 10 969) estimated in this research is much higher than that of hospitalization There are 1, 7 and 3 missing data in District, Health insurance and Family member monthly average income respectively associated with seasonal influenza (US$ 1 797) [11] and the healthcare costs per patient with severe acute respiratory syndrome (SARS) in Beijing (US$ 1 886) most likely due to higher rates of ICU admission and death [12, 13] and the use of more expensive modern medical devices [14] . The mean direct medical costs of hospitalized H7N9 patients were found to be ¥12 060 (US$1 861), ¥136 120 (US$21 006) and ¥218 610 (US$33 736) (estimated by model), or ¥12 790 (US$1 974), ¥96 780 (US$14 935) and ¥228 650 (US$35 285) (medians observed) for mild, severe and dead cases respectively in this study. cache = ./cache/cord-271149-qnhlfozo.txt txt = ./txt/cord-271149-qnhlfozo.txt === reduce.pl bib === id = cord-270799-2pmpspuj author = Zayet, Souheil title = Clinical features of COVID-19 and influenza: A comparative study on Nord Franche-Comte cluster date = 2020-06-16 pages = extension = .txt mime = text/plain words = 2849 sentences = 167 flesch = 57 summary = Fever or feeling of fever, fatigue, cough and pain 133 symptoms (myalgia, arthralgia and headache) were the fourth most prevalent symptoms for both 134 diseases (COVID-19 and influenza A/B) without significant statistical differences except for frontal 135 headache and other localization of headache. The onset of 145 these symptoms (from illness onset) didn't differ between the two groups except for fever which 146 appeared earlier in COVID-19 than in influenza (respectively 1.9 days [±1.5] vs 2.7 days [±1.5], 147 p=0.045). However, we noticed two otorhinolaryngological symptoms recently described 169 with SARS-CoV-2: anosmia and dysgeusia, present in half of our patients. On the other hand, sore throat, conjunctival hyperemia, tearing, sneezing, sputum production, 222 dyspnea, vomiting and rhonchi at pulmonary auscultation were more frequently described in 223 influenza group than COVID-19 group with statistically significant differences. cache = ./cache/cord-270799-2pmpspuj.txt txt = ./txt/cord-270799-2pmpspuj.txt === reduce.pl bib === id = cord-271220-sntawlnf author = Tadic, Marijana title = COVID‐19 and diabetes: Is there enough evidence? date = 2020-05-29 pages = extension = .txt mime = text/plain words = 2431 sentences = 127 flesch = 42 summary = Additionally, data indicate that hypertension, diabetes, and cardiovascular diseases are important risk factors for progression and unfavorable outcome in COVID‐19 patients. Even though the number of studies with follow-up is rather limited, these data are suggesting that hypertension, diabetes, and cardiovascular disease are underlying conditions associated with adverse outcome-admission in intensive care unit, mechanic ventilation, and death [6] [7] [8] [9] 13, 18 (Table 3) . In one of the largest study published (n = 1099) so far, diabetes was present in 7.4% of COVID-19 patients and it was significantly more prevalent in patients with severe form of disease and those who experienced primary outcome end point (admission to an intensive care unit, the use of mechanical ventilation, or death). In meta-analysis that included 1558 patients with COVID-19, it was found that diabetes, as well as hypertension and chronic obstructive pulmonary disease, was associated with exacerbation and admission to intensive care unit. cache = ./cache/cord-271220-sntawlnf.txt txt = ./txt/cord-271220-sntawlnf.txt === reduce.pl bib === id = cord-270628-jtj30v0r author = Alharthy, Abdulrahman title = Prospective Longitudinal Evaluation of Point‐of‐Care Lung Ultrasound in Critically Ill Patients With Severe COVID‐19 Pneumonia date = 2020-08-14 pages = extension = .txt mime = text/plain words = 4249 sentences = 250 flesch = 45 summary = [1] [2] [3] [4] [5] [6] Lung US was suggested to be particularly useful during the COVID-19 pandemic because of its ability to identify subtle lung parenchymal changes early in the course of disease, monitor the evolution of pulmonary lesions in hospitalized patients, and guide mechanical ventilation therapy in critically ill patients with acute respiratory failure and acute respiratory distress syndrome. [14] [15] [16] [17] [18] [19] [20] [21] [22] Chest computed tomography (CT) rapidly became the mainstream imaging method in the diagnosis and monitoring of COVID-19 pneumonia by identifying the typical pattern of ground glass opacities with variable infiltrates and consolidations, while showing a high correlation with laboratory detection of the virus by real-time polymerase chain reaction (RT-PCR) assays. [23] [24] [25] [26] [27] [28] [29] [30] Hence, in this study, the primary end point was to analyze the lung US findings in critically ill patients with severe COVID-19 pneumonia or admission to the ICU longitudinally throughout their disease course. cache = ./cache/cord-270628-jtj30v0r.txt txt = ./txt/cord-270628-jtj30v0r.txt === reduce.pl bib === id = cord-271262-xglhx928 author = Ghia, Samit title = “ANESTHESIA STAT” TO INTUBATE A COVID-19 PATIENT: IMPLICATIONS FOR THE ANESTHESIOLOGIST date = 2020-05-15 pages = extension = .txt mime = text/plain words = 3280 sentences = 184 flesch = 37 summary = Although reducing exposure of medical personnel is of obvious importance, there has been a dearth of literature discussing clinical strategies during the induction and intubation of COVID-19 patients. Ketamine could be a good agent for COVID-19 patient inductions; however, the anesthesiologist must be wary of cardiac failure with induction doses, especially if there is any preexisting history of cardiac disease or concern for viral cardiomyopathy. Prior to entering the COVID-19 patient's room, a review of the chart or a discussion with the primary team should include past medical history, current hemodynamic state, pertinent labs and findings, current medication regimens and the need to intubate over other strategies to improve oxygenation and ventilation. Upon entering the COVID-19 patient room, after securing appropriate personal and procedural equipment, the anesthesiologist should quickly move to the head of the bed while assessing the patient's current oxygenation and airway. cache = ./cache/cord-271262-xglhx928.txt txt = ./txt/cord-271262-xglhx928.txt === reduce.pl bib === id = cord-271887-blwrpf38 author = Sampa, Masuda Begum title = Redesigning Portable Health Clinic Platform as a Remote Healthcare System to Tackle COVID-19 Pandemic Situation in Unreached Communities date = 2020-06-30 pages = extension = .txt mime = text/plain words = 5654 sentences = 271 flesch = 47 summary = Our initial examination of the suitability of the PHC and its associated technologies as a key contributor to public health responses is designed to "flatten the curve", particularly among unreached high-risk NCD populations in developing countries. Portable Health Clinic (PHC) services, which is an RHS, have proven efficacy in providing necessary information and preventive measures for people without access to healthcare facilities [17] [18] [19] . No previous study to date has examined the scopes of designing and developing an RHS based on the general requirements to facilitate primary screening and triaging COVID-19 and primary healthcare services for preventing COVID-19 and controlling NCDs. However, such screening and triaging COVID-19 by an RHS is important for cost-effective check-ups and for reducing the risk of transmission for unreached communities with various needs. In its existing functional form, deploying the PHC and related RHS technologies for socially distanced populations during a public health emergency, such as the COVID-19 pandemic, is beneficial in reducing the risk of transmission to frontline healthcare professionals. cache = ./cache/cord-271887-blwrpf38.txt txt = ./txt/cord-271887-blwrpf38.txt === reduce.pl bib === id = cord-271212-y8denvju author = Xu, Xia title = Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China date = 2020-07-25 pages = extension = .txt mime = text/plain words = 3097 sentences = 165 flesch = 52 summary = title: Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. From February 3, 2020, to March 20, 2020, we conducted a retrospective study focusing on the clinical characteristics of confirmed cases of COVID-19 in Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, during which the rapid growth speed of diagnosis rated up to 58% in Wuhan, Hubei province. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China cache = ./cache/cord-271212-y8denvju.txt txt = ./txt/cord-271212-y8denvju.txt === reduce.pl bib === id = cord-271660-5sfkhg19 author = Sun, Hsin-Yun title = Impact of introducing fluorescent microscopy on hospital tuberculosis control: A before-after study at a high caseload medical center in Taiwan date = 2020-04-03 pages = extension = .txt mime = text/plain words = 3884 sentences = 192 flesch = 40 summary = METHODS: We measured the impact of switch to fluorescent microscopy on the smear detection rate of culture-confirmed pulmonary TB, timing of respiratory isolation, and total non-isolated infectious person-days in hospital at a high-caseload medical center (approximately 400 TB cases annually) in Taipei. Hospitalized patients had typical presentations of pulmonary TB if they had: (a) a prolonged cough for >3 weeks; (b) clinical suspicion of pulmonary TB based on chest radiography, such as cavitary pulmonary lesions, upper lobe diseases, or miliary lesions; or (c) already received a confirmed diagnosis of pulmonary TB by a positive sputum culture of Mycobacterium tuberculosis, positive acid-fast stain (AFS), or positive TB PCR, before the hospitalization. Our previous survey on age/sex-standardised TB incidence ratio of HCWs (using general population as reference)---the excess TB risk that are attributable to nosocomial TB transmission---in Medical Center A showed a drop of this risk, from 3.11 in 2006 to 1.37 in 2012 [23] , and the decrease in time-to-isolation and total non-isolated infectious patient-days was in parallel in the present study. cache = ./cache/cord-271660-5sfkhg19.txt txt = ./txt/cord-271660-5sfkhg19.txt === reduce.pl bib === id = cord-271871-8grkln6o author = Singer, J. S. title = Low Prevalence (0.13%) of COVID-19 Infection in Asymptomatic Pre-operative/Pre-procedure Patients at a Large Academic Medical Center Informs Approaches to Perioperative Care date = 2020-08-14 pages = extension = .txt mime = text/plain words = 2842 sentences = 158 flesch = 43 summary = Abstract Background The COVID-19 pandemic has resulted in reduced performance of elective surgeries and procedures at medical centers across the U.S. Awareness of the prevalence of asymptomatic disease is critical for guiding safe approaches to operative/procedural services. Conclusions These data demonstrating low levels (0.13% prevalence) of COVID-19 infection in an asymptomatic population of patients undergoing scheduled surgeries/procedures in a large urban area have helped to inform perioperative protocols during the COVID-19 pandemic. These data demonstrating low levels (0.13% prevalence) of COVID-19 infection in an asymptomatic 117 population of patients undergoing scheduled surgeries/procedures in a large urban area have helped to 118 inform perioperative protocols during the COVID-19 pandemic. As a large urban referral center, we adopted the CDC and ACS recommendations early in the pandemic, 327 suspending elective surgical and interventional procedures, and later relaxing those suspensions while 328 balancing local/regional COVID-19 epidemiology, data regarding our pre-operative/pre-procedure 329 testing results, and health system resources and priorities. cache = ./cache/cord-271871-8grkln6o.txt txt = ./txt/cord-271871-8grkln6o.txt === reduce.pl bib === id = cord-271920-1dzkgt6w author = Carpenter, Christopher R. title = Diagnosing COVID‐19 in the Emergency Department: A Scoping Review of Clinical Exam, Labs, Imaging Accuracy and Biases date = 2020-06-16 pages = extension = .txt mime = text/plain words = 7248 sentences = 523 flesch = 48 summary = 3 As waves of COVID-19 patients present to ED's in coming months with symptoms or potential exposures, understanding the diagnostic accuracy and reliability of history, physical exam, routine labs, advanced imaging, and an evolving array of COVID-19 diagnostics will be essential knowledge to inform the timing of testing, optimal specimen and test selection, shared decision-making, and ultimately derivation of clinical instruments to guide disposition, follow-up, and shared The search strategy used a combination of standardized terms and key words, including but not limited to (Covid-19 OR Novel Coronavirus OR SARS-COV-2) AND (diagnosis OR polymerase chain reaction OR serology OR CRISPR-CAS OR sensitivity/specificity) (Appendix). 40,42 It is known, however, that false negatives are frequent, so current recommendations advise incorporating patient's exposure risk, clinical signs and symptoms, routine lab and imaging findings, serology, and (when available) CT results into real-time determination of COVID-19 status. cache = ./cache/cord-271920-1dzkgt6w.txt txt = ./txt/cord-271920-1dzkgt6w.txt === reduce.pl bib === id = cord-271896-1ad18z11 author = Janowitz, Tobias title = Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series date = 2020-06-04 pages = extension = .txt mime = text/plain words = 3627 sentences = 202 flesch = 47 summary = CONCLUSIONS: The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with COVID-19. Based on a national institute of health (nih)-endorsed Protocol to research Patient experience of cOViD-19, we collected longitudinal severity scores of five symptoms (cough, shortness of breath, fatigue, headaches and anosmia) and general unwellness on a four-point ordinal scale modelled on performance status scoring. Based on a national institute of health (nih)-endorsed Protocol to research Patient experience of cOViD-19, we collected longitudinal severity scores of five symptoms (cough, shortness of breath, fatigue, headaches and anosmia) and general unwellness on a four-point ordinal scale modelled on performance status scoring. The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with cOViD-19. cache = ./cache/cord-271896-1ad18z11.txt txt = ./txt/cord-271896-1ad18z11.txt === reduce.pl bib === id = cord-272427-jqs00ilp author = Li, Yu-xuan title = The impact of COVID-19 on gastric cancer surgery: a single-center retrospective study date = 2020-10-02 pages = extension = .txt mime = text/plain words = 2656 sentences = 166 flesch = 50 summary = After admission during the COVID period, the waiting time before surgery was longer (PCG: 3[IQR: 2,5] vs. Based on our experiences during the pandemic period, we propose some surgical strategies for gastric cancer patients. We aimed to compare the differences in demographics, baseline characteristics, clinicopathological features, and health economics between the two groups to investigate the feasibility of gastric surgery during the pandemic of COVID-19. These data included patient demographics and baseline characteristics (sex, age, body mass index, comorbidity, clinical TNM classification, pathological TNM classification, hemoglobin, CEA, CA199, AFP, CA724), origin of patients (from local district or other provinces), operative method (open surgery or laparoscopic surgery), operating time, estimated blood loss, postoperative complications, postoperative fever, waiting time before admission, length of postoperative hospital stay, hospital costs etc. Length of postoperative hospital stay was defined as the period from the time when patient had undergone surgery to discharge. In conclusion, there are no studies on the impact of COVID-19 on gastric cancer patients. cache = ./cache/cord-272427-jqs00ilp.txt txt = ./txt/cord-272427-jqs00ilp.txt === reduce.pl bib === id = cord-271944-oxtus5vb author = Joseph, Rudman title = Seizure And COVID-19: Association and Review of Potential Mechanism date = 2020-10-13 pages = extension = .txt mime = text/plain words = 2360 sentences = 166 flesch = 48 summary = Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, this highly transmissible virus has since spread rapidly around the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a novel coronavirus that causes Coronavirus Disease of 2019 (COVID19) , a disease that can present with a variety of symptoms [1] . The most common symptoms at the onset of COVID-19 illness are fever, cough, and fatigue; in severe cases, patients may develop severe pneumonia, acute respiratory distress syndrome, and organ failure [4] . This article presents a review of the current literature on seizures linked with SARS-COV 2 infection and describes possible underlying mechanisms. describes the demographic data, time to onset of neurological symptoms, diagnostic criteria, intervention, and outcomes from 11 studies of seizures associated with SARS-COV-2 infection. cache = ./cache/cord-271944-oxtus5vb.txt txt = ./txt/cord-271944-oxtus5vb.txt === reduce.pl bib === id = cord-272143-6ej3eibd author = Benavides‐Nieto, Marta title = The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy date = 2018-12-21 pages = extension = .txt mime = text/plain words = 1875 sentences = 133 flesch = 40 summary = We have evaluated these infections in children with humoral immunodeficiencies who required immunoglobulin replacement therapy, considering their relationship with symptoms, lung function, bacterial co‐infection, and outcomes. CONCLUSIONS: In our experience, viral respiratory tract infections can cause significant respiratory symptoms and impaired lung function, in children with HID, despite immunoglobulin replacement therapy. Children with severe T-cell immunodeficiencies present impaired clearance of respiratory viruses, and pulmonary complications of viral infections are leading causes of morbidity and mortality in this group of patients. 1 However, the role of respiratory viruses in children with other types of primary immunodeficiency (PID), mainly those with humoral immunodeficiencies (HID) or diseases of immune dysregulation, has hardly been studied. 2, 7 We report, to the best of our knowledge, the first study that analyses respiratory viruses in pediatric patients with predominantly antibody deficiency who required IRT, considering their relationship with clinical symptoms and pulmonary function, bacterial co-infection, treatment and outcomes. cache = ./cache/cord-272143-6ej3eibd.txt txt = ./txt/cord-272143-6ej3eibd.txt === reduce.pl bib === id = cord-272553-bcmta2he author = Wang, Zhiqiang title = Clinical characteristics and laboratory results of pregnant women with COVID‐19 in Wuhan, China date = 2020-07-03 pages = extension = .txt mime = text/plain words = 1664 sentences = 103 flesch = 47 summary = METHODS: A retrospective study to review and compare clinical data including electronic medical records and laboratory tests from pregnant and nonpregnant patients admitted the Central Hospital of Wuhan, China from December 8, 2019 to April 1, 2020. Laboratory test results showed that levels of inflammation markers such as white blood cell count, neutrophil count and percentage, C‐reactive protein, procalcitonin, and D‐dimer were significantly higher in pregnant women, whereas mean lymphocyte percentage was significantly lower compared with nonpregnant women. Therefore, the aim of the present study was to investigate and report the clinical characteristics and laboratory test results of pregnant women with COVID-19 to strengthen the knowledge base. 6 The treatment strategy in the present study folThe clinical characteristics of pregnant patients extracted from medical records were gestational age; time interval between symptom onset and admission; time interval between hospitalization and delivery; delivery mode; length of hospital stay; initial symptoms (fever, cough, abdominal pain, blood-tinged mucus, ruptured membranes at term, chest tightness, asthma, fatigue, poor appetite, headache, nausea, and vomiting); and maternal comorbidities (gestational diabetes, gestational hypertension, intrahepatic cholestasis of pregnancy, premature rupture of membranes, and obesity). cache = ./cache/cord-272553-bcmta2he.txt txt = ./txt/cord-272553-bcmta2he.txt === reduce.pl bib === id = cord-272318-8yfg1j0o author = Reddy, Sujan T. title = Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series date = 2020-06-11 pages = extension = .txt mime = text/plain words = 3392 sentences = 197 flesch = 41 summary = To further characterize cerebrovascular disease (CVD) in COVID-19, we review the current literature of published cases and additionally report the clinical presentation, laboratory and diagnostic testing results of 12 cases with COVID-19 infection and concurrent CVD from two academic medical centers in Houston, TX, USA, between March 1 and May 10, 2020. To date, few studies have reported cerebrovascular complications in COVID-19 [3, 4] and 4 small case series have described the clinical and laboratory findings in patients with COVID-19 and concurrent stroke [5] [6] [7] [8] . We review the current literature of published cases and describe our experience of 12 cases with COVID-19 infection and concurrent cerebrovascular disease (CVD) to highlight the clinical presentation and proposed mechanisms of central nervous system (CNS) involvement by SARS-CoV-2. Additionally, we performed a retrospective chart review of all hospitalized cases with confirmed COVID-19 infection (SARS-CoV-2 RT-PCR positive) and CVD (ischemic and hemorrhagic stroke) between March 1 and May 10, 2020 seen at two comprehensive stroke centers in Houston, TX, USA. cache = ./cache/cord-272318-8yfg1j0o.txt txt = ./txt/cord-272318-8yfg1j0o.txt === reduce.pl bib === id = cord-272071-445ivhx0 author = Wunsch, Hannah title = Mechanical Ventilation in COVID-19: Interpreting the Current Epidemiology date = 2020-07-01 pages = extension = .txt mime = text/plain words = 2632 sentences = 124 flesch = 47 summary = What we are seeing in the current publications on COVID-19 are different rates of invasive mechanical ventilation across the world that have always existed, but these differences are now writ large because it is a particularly high-stakes game of worldwide data interpretation and a desperation to learn as much as possible from the experiences of others. This variability in preferences is intertwined with resources and always will be a huge factor in understanding the data coming out of different countries; for example, in 2008, Gray and colleagues published a large randomized controlled trial comparing noninvasive ventilation to conventional oxygen therapy for patients with acute cardiogenic pulmonary edema. Similarly, information on care preferences, such as how many patients preferred not to receive mechanical ventilation (because of age, comorbidity, or other personal preference) would aid in interpreting data, such as when reporting that only 20.2% of those who died with COVID-19 received this intervention (12) . cache = ./cache/cord-272071-445ivhx0.txt txt = ./txt/cord-272071-445ivhx0.txt === reduce.pl bib === id = cord-272727-a5ngjuyz author = Bertsimas, D. title = From predictions to prescriptions: A data-drivenresponse to COVID-19 date = 2020-06-29 pages = extension = .txt mime = text/plain words = 3596 sentences = 209 flesch = 53 summary = Specifically, we propose a comprehensive data-driven approach to understand the clinical characteristics of COVID-19, predict its mortality, forecast its evolution, and ultimately alleviate its impact. Each column reports 128 cohort-level statistics on demographics (e.g., average age, gen-129 der breakdown), comorbidities (e.g., prevalence of diabetes, 130 hypertension), symptoms (e.g., prevalence of fever, cough), 131 treatments (e.g., prevalence of antibiotics, intubation), lab 132 values (e.g., average lymphocyte count), and clinical outcomes 133 (e.g., average hospital length of stay, mortality rate). The models with lab values provide 309 algorithmic screening tools that can deliver COVID-19 risk 310 predictions using common clinical features. These findings 333 are also in agreement with clinical reports: an elevated CRP 334 generally indicates an early sign of infection and implies lung 335 lesions from COVID-19 (27), elevated levels of leukocytes 336 suggest cytokine release syndrome caused by SARS-CoV-2 337 virus (28), and lowered levels of serum calcium signal higher 338 rate of organ injury and septic shock (29) . cache = ./cache/cord-272727-a5ngjuyz.txt txt = ./txt/cord-272727-a5ngjuyz.txt === reduce.pl bib === id = cord-272585-346ef6qy author = Lombardi, JM title = Addressing a National Crisis: The Spine Hospital and Department's Response to the COVID-19 Pandemic in New York City date = 2020-05-31 pages = extension = .txt mime = text/plain words = 5078 sentences = 262 flesch = 51 summary = title: Addressing a National Crisis: The Spine Hospital and Department's Response to the COVID-19 Pandemic in New York City As peak infections spread across the United States, we hope this article will serve as a resource for other spine departments on how to manage patient care and healthcare worker deployment during the COVID-19 crisis. Our institution has been on the forefront of the COVID-19 pandemic, as we treated "patient zero" in New York City, who presented to our Emergency Department (ED) on February 28 th . Published data by healthcare providers in Asia and Europe demonstrated that the most substantial threat to COVID-19 patient morbidity and mortality was the lack of adequate critical care resources including intensive care unit (ICU) beds and respiratory support [8] [9] . It is vital to note that although redeployment was an important initiative to our department during this time of crisis, our primary concern was to maintain an adequate workforce to meet all orthopaedic surgical demands at our institution. cache = ./cache/cord-272585-346ef6qy.txt txt = ./txt/cord-272585-346ef6qy.txt === reduce.pl bib === id = cord-271483-33kuvpl7 author = Shojaei, Amirahmad title = COVID-19 and off label use of drugs: an ethical viewpoint date = 2020-05-08 pages = extension = .txt mime = text/plain words = 3184 sentences = 153 flesch = 42 summary = Based on USFDA regulation, investigational use of off-label medications helps the development of their safety and efficacy which needs to be used in the context of a clinical study protocol [18] . Likewise, we would like to define pseudo-research as using off-label medications in clinical practice without obtaining the patient's informed consent, and finally publishing the results of drug efficacy as a research article. To do this, the national and international regulatory bodies such as USFDA, and EU, as well as the national ones such as the National Committee of Ethics in Biomedical Research of Iran, should step out of their routine and codify a range of guidelines to address therapeutic and/or investigational use of off-label medications by highlighting the safety concerns of the off-label uses as well as respecting patients autonomy especially in critical situations such as the COVID-19 outbreak. However, the physicians should be careful that the information about the efficacy and safety of off-label medication in clinical practice should not be published as a research article. cache = ./cache/cord-271483-33kuvpl7.txt txt = ./txt/cord-271483-33kuvpl7.txt === reduce.pl bib === id = cord-272419-y3ebt4jm author = Monari, Caterina title = A Focus on the Nowadays Potential Antiviral Strategies in Early Phase of Coronavirus Disease 2019 (Covid-19): A Narrative Review date = 2020-08-09 pages = extension = .txt mime = text/plain words = 6476 sentences = 318 flesch = 46 summary = Possible inhibition of SARS-CoV-2 3-chymotrisyn-like (3CL)-protease and papain-like protease Lopinavir is excreted in the gastrointestinal (GI) tract, and thus coronavirus-infected enterocytes might be exposed to higher concentrations of the drug LPV/r tab 200/50 mg: 2 tab BID LPV/r oral sol 80/20 mg: 5 mL BID DRV/cobi tab 800/150 mg: 1 tab QD Gastrointestinal: diarrhea, nausea, vomiting, increased amylase, lipase, total cholesterol and triglycerides (risk factor for pancreatitis) Hepatotoxicity: increasing in GGT, AST, ALT, total bilirubin, hepatitis Cardiological: QT-and PR-interval prolongation, hypertension, bradyarrhytmias; torsade de pointes have been reported in patients treated with LPV/r Metabolical: hyperglycemia and diabetes mellitus, increased uric acid Recently, a randomized, controlled, open-label trial comparing the efficacy of LPV/r versus standard of care was conducted in 199 hospitalized adult patients with severe COVID-19: no significant difference between the two groups neither in the time of clinical improvement (hazard ratio [HR] 1.31; 95% CI 0.95-1.80; p 0.09), nor in the 28-day mortality rate (19.2% versus 25.0%; 95% CI −17.3 to 5.7) was observed [40] . cache = ./cache/cord-272419-y3ebt4jm.txt txt = ./txt/cord-272419-y3ebt4jm.txt === reduce.pl bib === id = cord-272154-nrm9ulj5 author = Gupta, Ravi title = Guidelines of the Indian Society for Sleep Research (ISSR) for Practice of Sleep Medicine during COVID-19 date = 2020-07-04 pages = extension = .txt mime = text/plain words = 5690 sentences = 354 flesch = 54 summary = Under these circumstances, the Indian Society for Sleep Research (ISSR) created a task force to develop guidelines for the practice of sleep medicine, not only for the Indian environment but also for other countries that are affected by the COVID-19 pandemic. As sleep services resume operations, there is a need to find innovative ways to reduce contact with COVID-19 patients, follow personal protection guidelines, as well as social distancing. Indian Society for Sleep Research (ISSR) created a task force to develop guidelines for the practice of sleep medicine that are applicable not only to India but also to other countries that are affected by the COVID-19 pandemic. Various levels of sleep studies, telemedicine, and positive airway pressure (PAP) therapy are the major aspects, given emphasis by the task force group of ISSR in these guidelines. cache = ./cache/cord-272154-nrm9ulj5.txt txt = ./txt/cord-272154-nrm9ulj5.txt === reduce.pl bib === id = cord-272135-a09bf50o author = Brouqui, Philippe title = Infection control in the management of highly pathogenic infectious diseases: consensus of the European Network of Infectious Disease date = 2009-04-22 pages = extension = .txt mime = text/plain words = 6629 sentences = 370 flesch = 48 summary = However, because the modes of infectious agent transmission are often underestimated, as was recently reported for infl uenza and SARS, 55 and because tuberculosis cannot be identifi ed without biological testing, EUNID recommends that droplet precaution should be upgraded to airborne precaution each time Situations in which a patient would need to be admitted to an HLIU • Patients with an unknown human-to-human transmittable or a potentially transmittable epidemic febrile illness that is native or imported from abroad • Patients with a known infectious disease caused by a group 3 or 4 agent* At admission of patients with HID to an emergency department • Systematically apply standard precautions and cough and respiratory etiquette • Set up at least one single room with a dedicated route and direct access, or an isolation room as recommended by EUNID for a referral hospital, † if HLIU cannot be used for ruling out HID diagnoses • Off er special training to the emergency department team • Retain close relationships with the HLIU team of the referral hospital cache = ./cache/cord-272135-a09bf50o.txt txt = ./txt/cord-272135-a09bf50o.txt === reduce.pl bib === id = cord-272112-egsha2j7 author = Tartarone, Alfredo title = COVID-19 and cancer care: what do international guidelines say? date = 2020-08-07 pages = extension = .txt mime = text/plain words = 2412 sentences = 111 flesch = 43 summary = The recently published Italian recommendations advise to evaluate case by case the possibility of postponing a treatment, considering the biological aspects of cancer, the clinical characteristics of the patient and the potential health risks for COVID-19 infection [9] . According to French guidelines, clinical management of cancer patients during the COVID-19 pandemic should be based on the following priority order: curative or non-curative intent of the treatment, age, life expectancy, time since diagnosis and symptoms [11] . TERAVOLT data confirmed a high mortality rate among patients with lung cancer who develop COVID-19; in both studies similar independent factors were associated with increased mortality, which included older age, number of comorbidities, poor performance status, active cancer and administration of chemotherapy alone or in combination with other treatments at the time of infection. cache = ./cache/cord-272112-egsha2j7.txt txt = ./txt/cord-272112-egsha2j7.txt === reduce.pl bib === id = cord-272975-gzsd4ybt author = Antony, Arun title = Systematic review of EEG findings in 617 patients diagnosed with COVID-19 date = 2020-10-19 pages = extension = .txt mime = text/plain words = 3554 sentences = 237 flesch = 46 summary = Significance EEG abnormalities are common in COVID-19 related encephalopathy and correlates with disease severity, preexisting neurological conditions including epilepsy and prolonged EEG monitoring. [6] [7] [8] Individual studies stress a specific population demographic or peculiar aspect of the EEG, but together provide a mosaic of EEG findings in varied groups from children to elderly, and asymptomatic patients to those with severe encephalopathy and status epilepticus. Here, we perform a systematic study of the EEG findings in patients with COVID-19 to synthesize the available data and to elucidate common patterns. Of interest, frontal lobe findings were common and included focal slowing, Diffuse background slowing was the most common EEG finding reported in two-thirds (68.6%) of patients indicating that a diffuse non-specific encephalopathy was the most common brain abnormality in this condition. The earliest available report of neurological complication of SARS-COV infection was a patient with respiratory failure and seizures, although EEG was not performed. cache = ./cache/cord-272975-gzsd4ybt.txt txt = ./txt/cord-272975-gzsd4ybt.txt === reduce.pl bib === id = cord-272655-qeojdpez author = Remolina, Yuly Andrea title = Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia date = 2015-11-17 pages = extension = .txt mime = text/plain words = 4309 sentences = 204 flesch = 42 summary = OBJECTIVES: To identify the viral aetiology in adult patients with severe acute respiratory infection (SARI) admitted to sentinel surveillance institutions in Bogotá in 2012. DESIGN: A cross-sectional study was conducted in which microarray molecular techniques for viral identification were used on nasopharyngeal samples of adult patients submitted to the surveillance system, and further descriptions of clinical features and relevant clinical outcomes, such as mortality, need for critical care, use of mechanical ventilation and hospital stay, were obtained. Under this initiative, countries have developed surveillance systems by following cases of influenza-like illness and severe acute respiratory infections (SARIs), which are clinically diagnosed among patients with fever, coughing or sore throat, difficulty breathing and the need for hospitalization [3] . In our study, viruses were identified as the most frequent causal agents of SARI requiring hospitalization in 2012, with most cases showing a high rate of viral co-infection, a high degree of morbidity, prolonged hospital stays and frequent needs for ICU management and mechanical ventilation. cache = ./cache/cord-272655-qeojdpez.txt txt = ./txt/cord-272655-qeojdpez.txt === reduce.pl bib === id = cord-273090-fdzkfo1u author = He, Susu title = Relationship between Chest CT manifestations and immune response in COVID-19 patients date = 2020-06-20 pages = extension = .txt mime = text/plain words = 2816 sentences = 140 flesch = 58 summary = In critically ill patients, the decrease of absolute value of CD4 + T cells and increase of IL-6 level are significantly correlated with the volume of lung lesions. There have been many reports that most of the 2019-nCoV patients have chest CT manifestations of pneumonia, typically showing bilateral ground-glass shadows and patchy shadows, and a few can also appear as consolidation shadows and interstitial lesions, the laboratory showed that the lymphocytes count in most patients decreased [6] [7] [8] [9] , with gradually worsened the disease, the lymphocytes absolute count continued to decline [9] , and has been There are reports in the literature that the proinflammatory cytokines IL-2, IL-6, IL-8, IL-10, and TNF-α are elevated in some 2019-nCoV patients [7] [8] . The purpose of this study is to investigate changes in lymphocytes counts and cytokines levels induced by 2019-nCoV and their effects on lung lesions, to determine the severity of the disease, and to select markers that could prompt early clinical intervention. cache = ./cache/cord-273090-fdzkfo1u.txt txt = ./txt/cord-273090-fdzkfo1u.txt === reduce.pl bib === id = cord-272630-2na1gndu author = Benito, Daniel A. title = Local spikes in COVID-19 cases: Recommendations for maintaining otolaryngology clinic operations date = 2020-08-20 pages = extension = .txt mime = text/plain words = 2089 sentences = 132 flesch = 48 summary = The Coronavirus Disease-2019 (COVID-19) pandemic has created an unprecedented economic and public health crisis in the United States. As healthcare system strain became imminent, the Centers for Medicare and Medicaid Services (CMS) 3 , the Surgeon General, and the American College of Surgeons (ACS) [4] recommended postponing elective procedures in efforts to mitigate the spread of disease and preserve personal protective equipment (PPE). [12] In addition, patients who may require office-based procedures should be screened and should be strongly considered to undergo COVID-19 testing prior to arrival, if possible ( Table 2 ). In-person examinations pose obvious risks of SARS-CoV2 (novel coronavirus) transmission among patients, family and friends of patients, and clinical staff. High-Risk Aerosol Generating Procedures in COVID-19: Respiratory Protective Equipment Considerations. Protecting patients and healthcare personnel from COVID-19: considerations for practice and outpatient care in cardiology How to train health personnel to protect themselves from SARS-CoV-2 (novel coronavirus) infection when caring for a patient or suspected case cache = ./cache/cord-272630-2na1gndu.txt txt = ./txt/cord-272630-2na1gndu.txt === reduce.pl bib === id = cord-272677-6t9kl3hq author = Wu, w. title = Key Points of Clinical and CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) Imported Pneumonia Based On 21 Cases Analysis date = 2020-03-06 pages = extension = .txt mime = text/plain words = 4067 sentences = 269 flesch = 56 summary = Conclusions: Fever and cough are the typical clinical features of NCP patients, and chest CT mainly manifested as multiple lesions in both lungs, often accompanied by GGO, vascular enlargement and cobblestone/reticular pattern.Changes in these main CT features can indicate development of the disease. Conclusions: Fever and cough are the typical clinical features of NCP patients, and chest CT mainly manifested as multiple lesions in both lungs, often accompanied by GGO, vascular enlargement and cobblestone/reticular pattern.Changes in these main CT features can indicate development of the disease Keywords: 2019-nCov; New coronavirus pneumonia; Chest CT; Ground glass opacification Based on the clinical observations and summary, the main diagnostic criteria [6] of 2019-nCov infections are : 1) Contact history of the epidemic area and related patients; 2) Nucleic acid is positive; 3) Fever, cough, shortness of breath and other clinical symptoms; 4) Laboratory examination showed that white blood cells were normal or decreased and lymphocytes decreased; 5) Lung lesions. cache = ./cache/cord-272677-6t9kl3hq.txt txt = ./txt/cord-272677-6t9kl3hq.txt === reduce.pl bib === id = cord-272778-aixiioii author = Chen, Qingqing title = Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China date = 2020-04-28 pages = extension = .txt mime = text/plain words = 3021 sentences = 175 flesch = 53 summary = We recorded demographic data including age and gender, the clinical data including underlying diseases, medical history, exposure history, symptoms, signs, laboratory findings, chest computed tomographic (CT) scans, and treatment measures (ie, antiviral therapy, corticosteroid therapy, respiratory support), Sequential Organ Failure Assessment (SOFA) score, MuLBSTA score, the Acute Physiology and Chronic Health Evaluation (APACHE) II, epidemiological, and outcomes data. For severely and non-severely ill patients, refer to Diagnosis and Treatment of Pneumonia caused by SARS-CoV-2 (version 7) [19] issued by of National Health Commission of the People's Republic of China. Last, we took reference on Diagnosis and Treatment of Pneumonia Caused by SARS-CoV-2 (version 7) [19] issued by of National Health Commission of the People's Republic of China, to define the severity of COVID-19, so its applicability may be limited. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study cache = ./cache/cord-272778-aixiioii.txt txt = ./txt/cord-272778-aixiioii.txt === reduce.pl bib === id = cord-273045-ele1cz86 author = Johnson, Claire D. title = Response of Practicing Chiropractors during the Early Phase of the COVID-19 Pandemic: A Descriptive Report date = 2020-06-13 pages = extension = .txt mime = text/plain words = 13963 sentences = 878 flesch = 54 summary = authors: Johnson, Claire D.; Green, Bart N.; Konarski-Hart, Karen K.; Hewitt, Elise G.; Napuli, Jason G.; Foshee, William K.; Brown, Jason W.; Kopansky-Giles, Deborah; Stuber, Kent J.; Lerede, Caterina; Charlton, Scott T.; Field, Jonathan R.; Botelho, Marcelo B.; Da Silva, Kendrah L.; Tønner, Gitte; Yap, Terrence BK.; Gkolfinopoulos, Vasileios S.; Quintero, Gabriel; Agaoglu, Mustafa H. 68 The Texas Board of Chiropractic Examiners issued guidelines on appropriateness of chiropractic care through April 30 that stated, "Licensees should only provide essential chiropractic services for patients with current or recurrent complaints of pain or disability which adversely affects the patient's ability to engage in the essential activities of daily living or work, or adversely affects the patient's quality of life, and with anticipation of material improvement under chiropractic care." 69 As of May 1, updated orders included that licensed chiropractors could provide wellness care but, "should continue to adhere to safety and prevention best practices specified in the most current advice from the Centers for Disease Control." 70 William Foshee. cache = ./cache/cord-273045-ele1cz86.txt txt = ./txt/cord-273045-ele1cz86.txt === reduce.pl bib === id = cord-272976-pb2bjpop author = Washington, Lacey title = ACR Appropriateness Criteria(®) on Acute Respiratory Illness date = 2009-10-01 pages = extension = .txt mime = text/plain words = 2856 sentences = 131 flesch = 33 summary = In a patient with acute respiratory illness (cough, sputum production, chest pain, and/or dyspnea), the need for chest imaging depends on the severity of illness, age of the patient, clinical history, physical and laboratory findings, and other risk factors. Chest radiographs seem warranted when one or more of the following are present: age ≥ 40; dementia; a positive physical examination; hemoptysis; associated abnormalities (leukocytosis, hypoxemia); or other risk factors, including coronary artery disease, congestive heart failure, or drug-induced acute respiratory failure. computed tomography (CT), depends on many factors, including the severity of the illness; the age of the patient; the presence of fever, leukocytosis, or hypoxemia; clinical history; the presence of other risk factors; and the results of physical examination. On the basis of these studies, chest radiography seems warranted in ARI when Ն1 of the following is present: age Ͼ40 years; dementia; positive results on physical examination; hemoptysis; associated abnormalities (leukocytosis, hypoxemia); or other risk factors, including coronary artery disease, congestive heart failure, or druginduced acute respiratory failure. cache = ./cache/cord-272976-pb2bjpop.txt txt = ./txt/cord-272976-pb2bjpop.txt === reduce.pl bib === id = cord-273426-55vu6b3u author = Iba, Toshiaki title = Coagulopathy of Coronavirus Disease 2019 date = 2020-05-26 pages = extension = .txt mime = text/plain words = 4536 sentences = 257 flesch = 31 summary = Conclusions: Severe acute respiratory syndrome coronavirus 2/ coronavirus disease 2019 frequently induces hypercoagulability with both microangiopathy and local thrombus formation, and a systemic coagulation defect that leads to large vessel thrombosis and major thromboembolic complications, including pulmonary embolism in critically ill hospitalized patients. Conclusions: Severe acute respiratory syndrome coronavirus 2/ coronavirus disease 2019 frequently induces hypercoagulability with both microangiopathy and local thrombus formation, and a systemic coagulation defect that leads to large vessel thrombosis and major thromboembolic complications, including pulmonary embolism in critically ill hospitalized patients. (Crit Care Med 2020; XX:00-00) Key Words: coagulopathy; coronavirus; coronavirus disease 2019; disseminated intravascular coagulation; hypercoagulability; thromboembolism I ncreasing communications worldwide have reported that hospitalized, critically ill coronavirus disease 2019 (COVID-19) patients are frequently developing laboratory abnormalities compatible with hypercoagulability and clinically a high prevalence of thromboembolic events (1). cache = ./cache/cord-273426-55vu6b3u.txt txt = ./txt/cord-273426-55vu6b3u.txt === reduce.pl bib === id = cord-273641-8l57mnjt author = Sadr, Sara title = Isolated severe thrombocytopenia in a patient with COVID-19: A case report date = 2020-05-29 pages = extension = .txt mime = text/plain words = 1438 sentences = 79 flesch = 46 summary = A narrow diagnostic approach where only febrile patients with pulmonary symptoms are evaluated for a COVID-19 diagnosis will result in many missed diagnoses; so it is important that physicians are familiar with atypical and rare presentations of COVID-19, such as isolated thrombocytopenia. The emerging disease caused by a novel coronavirus with a high transmission rate, predominantly pulmonary symptoms and a reported mortality rate ranging between 2.0-4.4% has become a global pandemic [1, 7, 8] , and the infection can cause systemic involvement including respiratory, neurological and hematopoietic complications [3, 4] . In another study which observed the hematologic impacts of COVID-19, 20 % of patients showed abnormalities that included mild thrombocytopenia as severe as it has been reported in other viral infections such as dengue fever [14] . Severe thrombocytopenia has been reported in one case of COVID-19 that was associated with pulmonary symptoms as well as neurological complications [15] . cache = ./cache/cord-273641-8l57mnjt.txt txt = ./txt/cord-273641-8l57mnjt.txt === reduce.pl bib === id = cord-273091-40gda9n9 author = Marrie, Thomas J. title = Empiric treatment of ambulatory community-acquired pneumonia: always include treatment for atypical agents date = 2005-03-01 pages = extension = .txt mime = text/plain words = 4364 sentences = 244 flesch = 45 summary = reviews studies that attempt to answer whether it is necessary to include antibiotics that are active against ''atypical'' pneumonia agents as part of the empiric therapy of CAP. Sobradillo and colleagues [55] performed a prospective randomized, double-blind study of doxycycline (Doryx) and erythromycin in the treatment of 48 patients who had Q fever pneumonia. Pneumonia requiring hospitalization: data from large retrospective studies and from observational studies Oosterheert and colleagues [68] performed a systematic review to determine the evidence for the current recommendations for the empiric antimicrobial therapy of patients hospitalized with CAP. There are no data from proper studies to answer whether it is necessary to include antibiotics that are active against atypical pneumonia agents as part of the empiric therapy of CAP. There are no data from proper studies to answer whether it is necessary to include antibiotics that are active against atypical pneumonia agents as part of the empiric therapy of CAP. cache = ./cache/cord-273091-40gda9n9.txt txt = ./txt/cord-273091-40gda9n9.txt === reduce.pl bib === id = cord-273602-cq276tj8 author = Bavishi, Chirag title = Acute myocardial injury in patients hospitalized with COVID-19 infection: A review date = 2020-06-06 pages = extension = .txt mime = text/plain words = 2116 sentences = 123 flesch = 39 summary = Randomized trials are urgently needed to investigate treatment modalities to reduce the incidence and mortality associated with COVID-19 related acute myocardial injury. In this concise review, we will focus on acute myocardial injury in COVID-19 infection, its prevalence, plausible pathophysiologic mechanisms, guidance on the use of cardiac biomarkers, and general management strategies. In a prospective cohort study by Du et al(11) of 179 patients with COVID-19 pneumonia, troponin I ≥0.05 ng/mL was independently associated with mortality in addition to age ≥65 years, pre-existing cardiovascular (CV) or cerebrovascular diseases and CD3+CD8+ Tcells ≤75 cells/μL. Epidemiological studies and randomized trials are urgently needed to investigate treatment modalities regulating immune function and inhibiting inflammatory responses to reduce the incidence and mortality associated with COVID-19 related acute myocardial injury. Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality cache = ./cache/cord-273602-cq276tj8.txt txt = ./txt/cord-273602-cq276tj8.txt === reduce.pl bib === id = cord-273869-buavj9mm author = Rosés-Gibert, Pau title = Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain date = 2020-09-08 pages = extension = .txt mime = text/plain words = 1892 sentences = 135 flesch = 49 summary = title: Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain METHODS: A retrospective descriptive study was performed collecting data on 36 patients under 14 years old, presenting suspicious acral skin manifestations for coronavirus disease 2019 (COVID-19). The management of patients presenting chilblain-like lesions and acral purpuric macules is not well established. Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients COVID-19) infection-induced chilblains: a case report with histopathological findings Chilblain and acral purpuric lesions in Spain during covid confinement: retrospective analysis of 12 cases Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients Chilblains-like lesions in children following suspected COVID-19 infection Assessment of acute acral lesions in a case series of children and adolescents during the COVID-19 pandemic cache = ./cache/cord-273869-buavj9mm.txt txt = ./txt/cord-273869-buavj9mm.txt === reduce.pl bib === id = cord-273119-jfy0iviy author = Julka-Anderson, Naman title = How COVID-19 is testing and evolving our communication skills date = 2020-06-25 pages = extension = .txt mime = text/plain words = 2275 sentences = 137 flesch = 68 summary = In UK radiotherapy departments, radiation therapist (review radiographer)-led clinics moved to telephone-based clinics to reduce the time spent by patients in a hospital environment. The pandemic has forced patients to slow down and really focus on themselves which has led to picking up physical and mental health changes earlier. As a radiation therapist (therapeutic radiographer) and member of the radiotherapy review team, I see patients throughout their radiotherapy treatments to address their physical and emotional side effects. Those of us in the radiotherapy review team have changed to telephone appointments to minimize time spent by patients in a hospital environment. Telephone reviews aren't a new process within healthcare (4); oncology teams use telephone triage when patients report treatment related side effects. In my opinion, radiotherapy reviews are more in depth than triage calls as they cover all aspects of a patient's care and side effects to help them live with and beyond cancer. cache = ./cache/cord-273119-jfy0iviy.txt txt = ./txt/cord-273119-jfy0iviy.txt === reduce.pl bib === id = cord-273283-gb0m6fue author = Altschul, David J. title = A novel severity score to predict inpatient mortality in COVID-19 patients date = 2020-10-07 pages = extension = .txt mime = text/plain words = 3372 sentences = 169 flesch = 49 summary = While the SOFA score is also predictive of mortality for COVID-19, it does not address the additional thrombotic mitigators of severe illness 11 www.nature.com/scientificreports/ development of disseminated intravascular coagulation (DIC), and now being used to help guide the use of anticoagulation for patients with COVID-19 [12] [13] [14] . This study is an observational cohort study validating a novel, simple COVID-19 in-hospital mortality score to predict inpatient mortality risk in 4711 patients with confirmed SARS-CoV-2 infection using a combination of presentation vital signs, and basic admission laboratory values. A ROC curve analysis was performed in the derivation cohort (Fig. 1) , the novel COVID-19 severity score achieved an AUC of 0.824 (95% CI 0.814-0.851) indicating a good discrimination for patients with higher risk www.nature.com/scientificreports/ www.nature.com/scientificreports/ of in-hospital mortality. cache = ./cache/cord-273283-gb0m6fue.txt txt = ./txt/cord-273283-gb0m6fue.txt === reduce.pl bib === id = cord-273175-bao8xxe2 author = Tran, Viet-Thi title = COVID-19–related perceptions, context and attitudes of adults with chronic conditions: Results from a cross-sectional survey nested in the ComPaRe e-cohort date = 2020-08-06 pages = extension = .txt mime = text/plain words = 3858 sentences = 205 flesch = 49 summary = It assessed participants' perception of their risk of severe illness with COVID-19; their context (i.e., work, household, contacts with external people); and their attitudes in situations involving frequent or occasional contacts with symptomatic or asymptomatic people. Results of the survey were described globally and for the subgroup of patients considered at high risk of a severe illness according to the French High Council for Public Health (Box 1). Among patients at high risk of a severe illness according to the French High Council for Public Health, 5% continued working, 15% had a household member working outside of the home and 7% reported regular contacts with people outside of their home. The only variable found associated with use of face masks with asymptomatic people (or refusal to see these people) was patients' perception of high risk of severe infection by COVID-19 (odds ratio 1.93, 95% confidence interval 1.53-2.43). cache = ./cache/cord-273175-bao8xxe2.txt txt = ./txt/cord-273175-bao8xxe2.txt === reduce.pl bib === id = cord-273567-8fp3a9h8 author = Zipprich, Hannah M. title = Knowledge, Attitudes, Practices, and Burden During the COVID-19 Pandemic in People with Parkinson’s Disease in Germany date = 2020-05-29 pages = extension = .txt mime = text/plain words = 5383 sentences = 276 flesch = 54 summary = Methods: Semi-structured telephone interviews were performed with 99 patients with Parkinson's disease (PD) and 21 controls to explore knowledge, attitudes, practices, and burden in order to elucidate nonadherence to preventive measures. Since then, local and national governments have taken unprecedented measures in response to the outbreak of SARS-CoV-2-induced coronavirus disease in 2019 (COVID-19), including quarantining infected individuals and their family members, canceling public transportation, exit controls, travel restrictions, contact restrictions, curfews, school closures, and requiring people to wear mouth and nose masks [4, 5] . The semi-structured questionnaire consisted of 22 questions to assess the patient's current situation and adherence to the ongoing regulations, with four of these questions examining the patient's knowledge of preventive measures (questions 4, 5, 6, and 7), three capturing their attitude toward the virus (questions 8, 9, and 16) , and six exploring practices and behavioral changes regarding COVID-19 (questions 10, 11, 12, 13, 14, and 15 ). cache = ./cache/cord-273567-8fp3a9h8.txt txt = ./txt/cord-273567-8fp3a9h8.txt === reduce.pl bib === id = cord-273875-vpp0l6ij author = Johnson, Miguel title = Creating a ‘safe haven’ for the most vulnerable; Early Reports of Management Strategies for Breast Cancer Patients in the UK during the COVID -19 Pandemic times date = 2020-09-20 pages = extension = .txt mime = text/plain words = 766 sentences = 40 flesch = 49 summary = title: Creating a 'safe haven' for the most vulnerable; Early Reports of Management Strategies for Breast Cancer Patients in the UK during the COVID -19 Pandemic times Standard cancer surgical and chemotherapy treatment requiring hospitalization or daily visit had to be suspended to reduce at the minimum the exposure of these vulnerable patients to the possible infection [2] . This thus creates a conundrum in the management of this cohort of patient in the COVID-19 era, as one must aim to prevent compromise to the standard of care while sensibly employing strategies to mitigate the acquisition of the COVID-19 virus in this highly vulnerable group. Our facility's reorganization strategies involved creating a "COVID-19 free" centre by employing rigorous screening protocols of all patients undergoing surgery as well as development of virtual teams [5] . The establishment of a COVID-19 free environment has allowed for the maintenance of the high standard of care in breast cancer patients, a highly vulnerable group [1] . cache = ./cache/cord-273875-vpp0l6ij.txt txt = ./txt/cord-273875-vpp0l6ij.txt === reduce.pl bib === id = cord-273929-kpcmy9x8 author = Shah, Jatin P. title = The impact of COVID‐19 on Head and Neck surgery, education, and training date = 2020-04-25 pages = extension = .txt mime = text/plain words = 2541 sentences = 122 flesch = 53 summary = With a fragile future, how do we conduct our day-to-day activities, and plan to retain our robust education and training programs, to educate and train the next generation of head and neck surgeons? 1 The drastic changes that have affected our work and life during the past 2 months have taught us that remote communications, education, teaching, learning and training are possible and have to be incorporated in our current systems. The IFHNOS has taken a lead on developing the first remote learning online fellowship program in head and neck surgery and oncology, which has been in existence for the past 6 years. In head and neck surgery, the stringent follow-up schedule was designed on the basis that nearly 80% of the patients who were to recur, would have recurred in the first 24 months, with a median time to recurrence of 9 months. The impact of COVID-19 on Head and Neck surgery, education, and training cache = ./cache/cord-273929-kpcmy9x8.txt txt = ./txt/cord-273929-kpcmy9x8.txt === reduce.pl bib === id = cord-273695-p5p7kvpp author = Fominskiy, Evgeny V. title = Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy date = 2020-07-13 pages = extension = .txt mime = text/plain words = 3510 sentences = 205 flesch = 54 summary = title: Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy BACKGROUND: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. OBJECTIVE: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. The present study aimed to assess the prevalence, patient characteristics clinical outcomes, and predictors of AKI and need of RRT in patients with COVID-19 receiving mechanical ventilation in the intensive care unit (ICU). This is the first report on the prevalence, patient characteristics, risk factors for, and outcome of AKI among COVID-19 patients receiving invasive ventilation in the ICU of a large tertiary hospital in a Western healthcare system. cache = ./cache/cord-273695-p5p7kvpp.txt txt = ./txt/cord-273695-p5p7kvpp.txt === reduce.pl bib === id = cord-273408-jtpaue0z author = Romeyke, Tobias title = COVID-19 Case Report: An 84-Year-Old Man with Exacerbation of Multiple Comorbidities Due to COVID-19 Managed by a Multidisciplinary Team Using Patient-Reported Outcomes date = 2020-08-21 pages = extension = .txt mime = text/plain words = 3045 sentences = 201 flesch = 48 summary = Patient: Male, 84-year-old Final Diagnosis: Acute bronchitis • chronic multiple pain with spondylosis with radiculopathy: lumbar region • chronic renal failure CKD 4 • derailed type 2 diabetes mellitus • diabetes mellitus type 2 • eart failure • hyperuricaemia • progressive aortic stenosis • pulmonary hypertension • SARS-CoV2 Symptoms: Appetite loss • fever • pain • sore throat Medication: — Clinical Procedure: — Specialty: General and Internal Medicine OBJECTIVE: Unusual clinical course BACKGROUND: When treating patients with comorbidities who are infected with severe acute respiratory syndrome as a result of SARS-CoV-2, it is crucial to offer multidisciplinary treatment that takes into consideration all of the health conditions with which they have been diagnosed. We collected clinical and patient-reported data on quality of life, physical functions, the sensation of pain, psychological well-being, and symptoms while taking into account the degree of chronicity of the conditions, the level of the patient's pain, and his hospitalization in an isolation ward. cache = ./cache/cord-273408-jtpaue0z.txt txt = ./txt/cord-273408-jtpaue0z.txt === reduce.pl bib === id = cord-273587-nja58vxw author = Rendeiro, A. F. title = Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression date = 2020-09-09 pages = extension = .txt mime = text/plain words = 8910 sentences = 467 flesch = 46 summary = By profiling mild and severe COVID-19 patients and healthy donors with flow cytometry, we demonstrate that SARS-CoV-2 is associated with broad dysregulation of the circulating immune system, characterized by the relative loss of lymphoid cells coupled to expansion of myeloid cells. While we observed no significant differences in the relative abundance of KIR receptors among COVID-19 patients with mild disease and healthy controls (Figure 3f) , a significantly higher proportion of cells expressed CD158i (NKG2A) in severe patients compared with mild or convalescent individuals. Despite the backdrop of a relative decrease in B cell numbers as disease progresses, we observed only a mild, non-significant increase in plasmacytoid cells in patients with severe COVID-19 compared with healthy donors (Figure 4a) . The resulting network of significant effects identified several clinical factors associated with specific immune cell populations, highlighting how age, sex, and disease severity jointly influence the circulating immune systems in patients with COVID-19 (Figure 6a) . cache = ./cache/cord-273587-nja58vxw.txt txt = ./txt/cord-273587-nja58vxw.txt === reduce.pl bib === id = cord-274199-3stjueja author = Baldi, Enrico title = COVID-19 kills at home: the close relationship between the epidemic and the increase of out-of-hospital cardiac arrests date = 2020-06-20 pages = extension = .txt mime = text/plain words = 4307 sentences = 193 flesch = 48 summary = Our aim was to assess whether the difference in the number of OHCAs between 2020 and 2019 was statistically correlated with the COVID-19 epidemic trend and to look for clinical pre-hospital elements supporting this evidence. All the Emergency Medical System (EMS) electronic records have been reanalysed and the number of patients with suspected COVID-19 (fever for at least 3 days before OHCA associated with cough and/or dyspnoea) or with a diagnostic pharyngeal swab (performed before OHCA or after death) have been computed. We highlighted an increase in medical aetiology over other types of aetiologies, and this further reinforces the hypothesis that the increase in the incidence of OHCAs is probably related to the direct (i.e. respiratory failure at home, SCD due to SARS-CoV-2 myocardial involvement or treatment) or indirect (i.e. lack of EMS activation in the case of time-dependent pathologies) effect of the COVID-19 epidemic. cache = ./cache/cord-274199-3stjueja.txt txt = ./txt/cord-274199-3stjueja.txt === reduce.pl bib === id = cord-273614-qmp2tqtb author = Tahir, Faryal title = Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): A Comprehensive Review date = 2020-05-08 pages = extension = .txt mime = text/plain words = 7164 sentences = 413 flesch = 53 summary = However, multiple studies that highlight the clinical features, laboratory findings, and prognosis of acute myocardial injury (AMI) in COVID-19-affected individuals have been published. The study concluded that severe respiratory illness with 2019n-CoV infection with deteriorating complications was associated with ICU admission and a higher mortality rate [24] . This study concluded that patients with very severe COVID-19 have a higher percentage of increased cTnI levels and their mortality rate can be improved by protecting them from myocardial injury [40] . The study concluded that cardiac injury is a prevalent condition among hospitalized patients with COVID-19 in Wuhan, China, and it is associated with a higher risk of in-hospital mortality [41] . Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study (Epub ahead of print) Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China (Epub ahead of print) cache = ./cache/cord-273614-qmp2tqtb.txt txt = ./txt/cord-273614-qmp2tqtb.txt === reduce.pl bib === id = cord-274184-hm516x6p author = Elli, Luca title = Endoscopy during the Covid-19 outbreak: experience and recommendations from a single center in a high-incidence scenario date = 2020-04-27 pages = extension = .txt mime = text/plain words = 4843 sentences = 280 flesch = 50 summary = From the abovementioned reasons we must deduce that: -in high SARS-CoV-2 incidence areas where PCR assays are not extensively performed, Covid-19 cannot be ruled out by simple clinical examination or epidemiological link; -the greatest amount of efforts and precautions are required to minimize the spread of the disease and to preserve medical staff from infection. In our current situation, which is characterized by high incidence of Covid-19 and relative scarcity of surveillance assays in asymptomatic subjects, for the abovementioned reasons we recommend different modalities of individual protection based on a strict clinical and epidemiological stratification of patients with potential SARS-CoV-2 infection undergoing endoscopic examination. In this setting, regardless of the classification of patients (high/low-risk, , in order to prevent the medical staff from becoming infected, we suggest high-performance personal protection equipment, i.e. a N95 or FFP2/FFP3 respirator, a hairnet, a double pair of gloves, a disposable waterproof surgical gown, a face shield (which we prefer because it allows to protect, and then spare, respirators) or goggles, and work safety clogs (Table 1) . cache = ./cache/cord-274184-hm516x6p.txt txt = ./txt/cord-274184-hm516x6p.txt === reduce.pl bib === id = cord-273913-xem3alih author = Marraha, Farah title = A Review of the Dermatological Manifestations of Coronavirus Disease 2019 (COVID-19) date = 2020-08-11 pages = extension = .txt mime = text/plain words = 4225 sentences = 234 flesch = 48 summary = In this review, we discuss these various cutaneous manifestations and skin problems related to personal protective equipment, as well as different cutaneous anti-COVID-19 drug-associated reactions. e first case infected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was reported in Wuhan, China, in late November 2019. ese skin lesions can guide clinicians for diagnosis if the patients present other COVID-19 symptoms; however, viral infection cannot be the only cause; mediated inflammatory responses and drug reactions can also be suspected. e aim of our literature review is to report the various cutaneous manifestations described to date associated with COVID-19, the skin problems related to personal protective equipment, and the different cutaneous anti-COVID-19 drug reactions [6, 7] . e frequency of the skin lesions associated with COVID-19 infection varies according to the series; in a Chinese study of 1099 positive cases, the incidence was only 0.2%, while in an Italian series of 88 patients it was 20.4% [42] . cache = ./cache/cord-273913-xem3alih.txt txt = ./txt/cord-273913-xem3alih.txt === reduce.pl bib === id = cord-274250-95yzt1gj author = Mortaz, Esmaeil title = Silent hypoxia: higher NO in red blood cells of COVID-19 patients date = 2020-10-16 pages = extension = .txt mime = text/plain words = 2716 sentences = 159 flesch = 48 summary = The major clinical feature of severe COVID-19 requiring ventilation is acute respiratory distress syndrome (ARDS) with multi-functional failure as a result of a cytokine storm with increased serum levels of cytokines. The kinetics and allosteric regulation of Hb nitrosylation by oxygen and pH are consistent with the physiologic mechanisms that modulate tissue blood flow, namely acidosis and hypoxemia and tissue hypoxia leads to NO generation by the RBC via SNO-protein transfer of NO activity [12] . To examine the hypothesis that NO is important in regulating vasodilation during hypoxia in these subjects we studied intracellular levels of NO in COVID-19 patients. In our study, intracellular RBC NO of COVID-19 patients is significantly higher than in healthy controls and this may enable the release of oxygen to tissues resulting in the clinical manifestation of silent hypoxia in these patients. cache = ./cache/cord-274250-95yzt1gj.txt txt = ./txt/cord-274250-95yzt1gj.txt === reduce.pl bib === id = cord-273317-2e3vmdx4 author = Shekhar, Rahul title = Neurological Complications Among Native Americans with COVID-19: Our Experience at a Tertiary Care Academic Hospital in the U.S. date = 2020-08-24 pages = extension = .txt mime = text/plain words = 1488 sentences = 109 flesch = 56 summary = OBJECTIVE: To study the central nervous system (CNS) complications in patients with COVID-19 infection especially among Native American population in the current pandemic of severe acute respiratory syndrome virus (COVID-19). METHODS: Patients with confirmed COVID-19 infection at University of New Mexico hospital (UNMH) were screened for development of neurological complications during Feb 01 to April 29, 2020 via retrospective chart review. Out of seven patients, majority were Native Americans females, and developed neurological complications including subarachnoid hemorrhage (SAH), Intraparenchymal hemorrhage (IPH), Ischemic stroke (IS) and seizure. CONCLUSION: Patients with serious CNS complications secondary to COVID-19 infection were observed to be Native Americans. 4 We share a case series of seven patients, all except one of whom, were Native Americans (NA), and experienced CNS complications during the admission of COVID-19. Patients diagnosed with COVID-19 via reverse transcriptase-polymerase chain reaction (RT-PCR) from nasal swab were screened for development of neurological complications (ischemic stroke, intracerebral hemorrhage, sub-arachnoid hemorrhage, seizure, and encephalitis). cache = ./cache/cord-273317-2e3vmdx4.txt txt = ./txt/cord-273317-2e3vmdx4.txt === reduce.pl bib === id = cord-273758-hhd8xnve author = Ciardullo, S. title = Impact of diabetes on COVID-19-related in-hospital mortality: a retrospective study from Northern Italy date = 2020-08-10 pages = extension = .txt mime = text/plain words = 3404 sentences = 164 flesch = 46 summary = Nonetheless, it remains controversial whether diabetes could be considered an independent risk factor for greater severity of illness and death, with some studies showing a detrimental effect [5] [6] [7] and others a neutral influence [8] [9] [10] , also depending on adjustment for confounding variables. As expected, patients who experienced in-hospital death were older (78 vs 68 years, p < 0.001) and had a higher prevalence of most comorbidities including CVD (46.4% vs 32.5%, p = 0.007) and hypertension (78.1 vs 56.8%, p < 0.001), whereas only a trend was found for diabetes (23.2 vs 15.6%, p = 0.064) and no significant differences were found in gender distribution. In the present study we show that among patients hospitalized for COVID-19 in a single center in Northern Italy, a history of diabetes was associated with an increased mortality risk, which was independent from several confounding factors and comorbidities. cache = ./cache/cord-273758-hhd8xnve.txt txt = ./txt/cord-273758-hhd8xnve.txt === reduce.pl bib === id = cord-274542-fpzk5k79 author = Patti, Giuseppe title = Questions and Answers on Practical Thrombotic Issues in SARS-CoV-2 Infection: A Guidance Document from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology date = 2020-11-03 pages = extension = .txt mime = text/plain words = 5628 sentences = 239 flesch = 32 summary = UFH should be limited to patients with CrCl < 30 mL/min An invasive "catheter"-based therapy for PE is indicated in selected cases with contraindication to anticoagulant drugs, recurrent events despite adequate anticoagulation, or when systemic fibrinolysis cannot be performed For the risk stratification of patients with VTE, monitoring of the following parameters is useful: troponin, BNP, D-dimer, blood cell count, fibrinogen, prothrombin time, activated partial thromboplastin time, and degradation products of fibrin After the initial approach, DOACs may represent an option for in-hospital treatment of a VTE episode in patients with clinical stability and decreasing inflammation After a VTE episode, DOACs should represent the therapy of choice at discharge The use of imaging techniques in diagnosing a VTE episode is complex, because of the risk of viral transmission to other patients and to healthcare workers, and must be regulated by specific in-hospital protocols aimed at limiting such risk. cache = ./cache/cord-274542-fpzk5k79.txt txt = ./txt/cord-274542-fpzk5k79.txt === reduce.pl bib === id = cord-274481-k1dp1ilv author = Falavigna, Maicon title = Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology date = 2020 pages = extension = .txt mime = text/plain words = 6973 sentences = 447 flesch = 44 summary = Summary of the evidence: the systematic review identified three comparative clinical trials with available data on the effects of hydroxychloroquine (HCQ) in COVID-19 patients: two open randomized clinical trials (29, 30) in a patient population with mild to moderate disease, and one cohort study. Recommendation 2 -we suggest against the routine use the hydroxychloroquine or chloroquine plus azithromycin combination for treatment of COVID-19 patients (weak recommendation; Level of Evidence very low). Recommendation 4 -We suggest the use of empirical oseltamivir treatment in patients with Severe Acute Respiratory Syndrome (SARS) or flu-like syndrome with risk factors for complications when a diagnosis of influenza cannot be ruled out (weak recommendation; Level of Evidence very low). Summary of the evidence -two randomized clinical trials assessed the use of lopinavir/ritonavir in COVID-19 patients. cache = ./cache/cord-274481-k1dp1ilv.txt txt = ./txt/cord-274481-k1dp1ilv.txt === reduce.pl bib === id = cord-274008-p3st70u3 author = Mann, E. R. title = Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis date = 2020-06-16 pages = extension = .txt mime = text/plain words = 6004 sentences = 359 flesch = 49 summary = Here we report the outcome of a longitudinal immune profiling study in hospitalised patients during the peak of the COVID-19 pandemic in the UK and show the relationship between immune responses and severity of the clinical presentation. Although, as reported previously 4 , a higher neutrophil to lymphocyte ratio (NLR) on hospital admission was observed in those patients whose disease trajectory was ultimately severe, whereas there were no appreciable differences observed in monocytes (figure 1A, 1B and table 1). Longitudinal analysis revealed that in the majority of patients (70%) (irrespective of severity) T cell frequencies in whole blood increased prior to hospital discharge, while neutrophil frequencies reciprocally decreased (figure 1E). Severe COVID-19, on the other hand, was associated with monocytes displaying increased expression of the cell cycle marker, Ki67 (normally <5% in healthy peripheral blood), irrespective of whether monocytes were stimulated or not (figure 3C and appendix 6C), which strongly correlated with hospital data for CRP (figure 3C). cache = ./cache/cord-274008-p3st70u3.txt txt = ./txt/cord-274008-p3st70u3.txt === reduce.pl bib === id = cord-273945-b1lekw47 author = Bongiovanni, Alberto title = Comment on ‘Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey” by Alice Indini et al. date = 2020-05-16 pages = extension = .txt mime = text/plain words = 606 sentences = 37 flesch = 47 summary = title: Comment on 'Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey" by Alice Indini et al. Comment on 'Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey" by Alice Indini et al. In this scenario a multidisciplinary approach is useful because it permits a more accurate identification of SRE risk , avoiding unnecessary medical visits, orienting patients towards the right procedure/treatment, reducing contact with healthcare operators and consequently lowering the risk of COVID-19 contamination even if the multidisciplinary meeting seems to be contraindicated. However, in the present COVID-19 emergency greater emphasis is needed on risk assessment, prevention strategies and effective therapies in order to optimise oncologic resources and to guarantee the patients' continuum of care. We believe our experience could provide a feasible model of care to manage BM patient and at the same time prevent and reduce COVID-19 infection. cache = ./cache/cord-273945-b1lekw47.txt txt = ./txt/cord-273945-b1lekw47.txt === reduce.pl bib === id = cord-274494-heu6rmbt author = Pablos, Jose L title = Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases date = 2020-06-12 pages = extension = .txt mime = text/plain words = 3116 sentences = 170 flesch = 36 summary = 10 11 Since timely obtaining methodologically rigorous data on the prevalence of severe SARS-CoV-2 infection in our patients under different therapies is challenging at this moment, 8 we have performed an exploratory analysis of the relative prevalence of hospital-diagnosed COVID-19 in large multicentric cohorts of rheumatic patients under follow-up. All aggregated groups of patients with AI/IMID showed higher rates of COVID-19, and analyses of the different groups confirmed increased prevalence in all diagnostic groups but SLE, where it was remarkably lower than those in the other groups and similar to that in the reference population (table 1 and figure 1 ). Our systematic approach identified a significant number of patients with different rheumatic conditions and immunomodulatory therapies with SARS-CoV-2 PCR-confirmed diagnosis that allowed us to describe the prevalence of hospital COVID-19 and to identify differences between diagnostic and therapeutic groups. cache = ./cache/cord-274494-heu6rmbt.txt txt = ./txt/cord-274494-heu6rmbt.txt === reduce.pl bib === id = cord-274666-0d8oz51l author = Han, Yi title = Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study date = 2020-06-24 pages = extension = .txt mime = text/plain words = 3807 sentences = 197 flesch = 54 summary = Conclusions: This study showed that LDH could be identified as a powerful predictive factor for early recognition of lung injury and severe COVID-19 cases. To assess the risk factors of the demographics, characteristics, and laboratory indicators on the severity of COVID-19 patients, logistic regression analysis was performed on the parameters of significant difference using t test. Apart from the risk factors above, patient age, white blood cell count, neutrophil count, serum AST, ALT, LDH, Urea, CRP, and D-dimer level were all associated with the severity of COVID-19 patients. As a result, serum lymphocytes (OR:0.2, 95% CI:0.04-0.96, P < 0.05), CRP (OR:1.026, 95% CI:1.006-1.046, P < 0.05), and LDH (OR:1.009, 95% CI:1.002-1.016, P < 0.05) were found to be independent risk factors for the severity of COVID-19 patients ( Table 3) . And importantly, lymphocytes, especially CD3 + , CD4 + , and CD8 + T cells in the peripheral blood of COVID-19 patients, which was relevant with serum LDH, were also dynamically correlated with the severity of the disease. cache = ./cache/cord-274666-0d8oz51l.txt txt = ./txt/cord-274666-0d8oz51l.txt === reduce.pl bib === id = cord-274632-d9z0m2l8 author = Chenna, Avantika title = Coronavirus Disease 2019 (COVID-19) in a Renal Transplant Patient date = 2020-05-09 pages = extension = .txt mime = text/plain words = 1265 sentences = 77 flesch = 46 summary = Transplant patients are particularly at a higher risk of contracting COVID-19 because of their immunosuppressed state, and they have the propensity to develop opportunistic infections [1] . Transplant patients are particularly at a higher risk of contracting COVID-19 because of their immunosuppressed state, and they have the propensity to develop opportunistic infections [1] . Here, we describe a case of a renal transplant patient who developed COVID-19 and, unfortunately, died from the infection despite all medical management. The illness from COVID-19 in renal transplant recipients ranged from mild to severe, and few patients presented with atypical symptoms [1, 3] . Transplant patients constitute a population more vulnerable to develop COVID-19 because of their immunosuppressed state and higher risk for opportunistic infections. Case report of COVID-19 in a kidney transplant recipient: does immunosuppression alter the clinical presentation? Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19) cache = ./cache/cord-274632-d9z0m2l8.txt txt = ./txt/cord-274632-d9z0m2l8.txt === reduce.pl bib === id = cord-274557-2071770h author = Späth, Peter J. title = On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events date = 2015-02-05 pages = extension = .txt mime = text/plain words = 10243 sentences = 530 flesch = 40 summary = i.e., cold-ethanol or ion-exchange chromatography, contaminants, route of application, i.e., intra muscular (IMIG), intravenous (IVIG), or subcutaneous (SCIG), the rate of increase of the exogenous IgG in the circulation of the recipient over time and, last but not least an eventually existing risk factor from patients' side ( Figure 1 ) as well as incorrect handling of the concentrate are factors having a role in inducing non-infectious AEs related to administration of IgG concentrates ( Table 1) . The complement-mediated AEs were considered to be caused by aggregates in the product ("spontaneous complement activation" or anti-complementary activity or ACA) or by in vivo formation of immune complexes (ICs, patient's condition related; e.g., subclinical infections or the unnoticed presence of anti-IgA antibodies) and therefore only IgG concentrates with low or absent ACA is accepted by authorities for human use. cache = ./cache/cord-274557-2071770h.txt txt = ./txt/cord-274557-2071770h.txt === reduce.pl bib === id = cord-274245-pgfqkwqg author = Rali, Aniket S title = Cardiopulmonary Ultrasonography for Severe Coronavirus Disease 2019 Patients in Prone Position date = 2020-05-14 pages = extension = .txt mime = text/plain words = 528 sentences = 38 flesch = 45 summary = title: Cardiopulmonary Ultrasonography for Severe Coronavirus Disease 2019 Patients in Prone Position Upon arrival to the emergency room, the patient was noted to be severely hypoxaemic by pulse oximetry (66%) and in impeding respiratory failure, so she was emergently intubated for mechanical ventilatory support. The patient's chest X-ray at the time of admission showed diffuse bilateral pulmonary opacities consistent with multifocal pneumonia or pulmonary oedema ( Figure 1 ). Polymerase chain reaction (PCR) testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was sent and came back positive after 48 hours. The patient was diagnosed with severe acute respiratory distress syndrome (ARDS), so was treated with inhaled pulmonary vasodilators, neuromuscular blockade and prone-position ventilation. Forty-eight hours after initial presentation, the patient's PCR testing for SARS-CoV-2 returned positive, confirming the diagnosis of COVID-19. Critical care ultrasonography in acute respiratory failure cache = ./cache/cord-274245-pgfqkwqg.txt txt = ./txt/cord-274245-pgfqkwqg.txt === reduce.pl bib === id = cord-274331-0i2opmcn author = Wang, Catherine J. title = COVID‐19 infection on IL‐23 inhibition date = 2020-07-14 pages = extension = .txt mime = text/plain words = 388 sentences = 32 flesch = 53 summary = Given mild symptoms, the patient was discharged. The patient was discharged 1 week later on home quarantine. The patient in this manuscript has given informed consent to publication of his case details. In our case, the patient recovered from COVID-19 before his next scheduled risankizumab dose. However, more data needs to be obtained about biologics in COVID-19 patients, in particular whether or not biologic dosage timeline should be adjusted based on resolution of infection. A database to collect information on COVID-19 patients on biologic therapy and their outcomes would be instrumental to guide clinicians on best practices for now and in future pandemics. In conclusion, this case illustrates that IL-23 inhibition via biologic therapy in COVID-19 may not correlate with severe respiratory disease. TH17 responses in cytokine storm of COVID-19: an emerging target of JAK2 inhibitor Fedratinib SARS-CoV-2 infection in a psoriatic patient treated with IL-23 inhibitor cache = ./cache/cord-274331-0i2opmcn.txt txt = ./txt/cord-274331-0i2opmcn.txt === reduce.pl bib === id = cord-273996-z5vlw6nm author = Di Dalmazi, Guido title = Comparison of the effects of lockdown due to COVID-19 on glucose patterns among children, adolescents, and adults with type 1 diabetes: CGM study date = 2020-10-28 pages = extension = .txt mime = text/plain words = 4895 sentences = 243 flesch = 51 summary = The aims of the study were to investigate continuous glucose monitoring (CGM) metrics in children and adults with T1D during lockdown and to identify their potentially related factors. In adults, considering the changes in SDglu and TIR occurred before and during lockdown, we identified a group with improved TIR and SDglu who performed more physical activity, one with improved glucose variability who was younger than the other patients, and one with worsened glucose variability who showed higher perceived stress than others. ► Time in range and SD of glucose measured by CGM improved in adult patients with type 1 diabetes during lockdown due to the COVID-19 pandemic. To perform unsupervised clustering, we did not consider %CV among parameters of glycemic variability because it was not significantly different between the time periods before and during lockdown neither in the whole groups of patients nor in the three groups divided by age-range (children, teenagers, and adults), according to paired-samples comparison. cache = ./cache/cord-273996-z5vlw6nm.txt txt = ./txt/cord-273996-z5vlw6nm.txt === reduce.pl bib === id = cord-274782-yymo9i6r author = Şahbat, Yavuz title = Management of orthopedic oncology patients during coronavirus pandemic date = 2020-07-02 pages = extension = .txt mime = text/plain words = 1930 sentences = 116 flesch = 49 summary = At first glance, the coronavirus disease 2019 (COVID‐19) pandemic and orthopedics may seem to be unrelated disciplines, but the provision of healthcare services to patients who require them proves that these two fields are parts of the same whole. The main purpose of this article is to discuss how orthopedic oncology clinics should be organized during the pandemic and to present the process management scheme for patients requiring orthopedic surgery, including trauma surgery, from diagnosis to treatment, together with our experiences. The main purpose of this article is to discuss how orthopedic oncology clinics should be organized during the pandemic and to present the process management scheme for patients requiring orthopedic surgery, including trauma surgery, from diagnosis to treatment, together with our experiences. We obtained data from the hospital information system regarding all oncologic orthopedics and trauma surgery patients operated on and followed between 11 March 2020, the date of the first confirmed case of coronavirus in Turkey, and 11 May 2020. cache = ./cache/cord-274782-yymo9i6r.txt txt = ./txt/cord-274782-yymo9i6r.txt === reduce.pl bib === id = cord-274563-jimw6skv author = Fiumara, Agata title = COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date = 2020-08-22 pages = extension = .txt mime = text/plain words = 3524 sentences = 163 flesch = 50 summary = During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. Methods: Based on the feeling that our patients were experiencing profound distress, we designed a structured telephone interview with the aim to evaluate how, and to which extent, the pandemic outbreak was changing their behavior and feelings about their chronic disease, the impact on therapies, and future expectations. Moreover, a striking similarity emerged between the groups regarding forced home reclusion and the profound feeling to be excluded by normal life, well-known to those affected by a chronic rare disease. Based on the feeling that our patients were experiencing profound distress, we designed a structured interview [3, 4] with the aim to evaluate how, and to which extent, the COVID-19 pandemic was changing our patients' behavior and feelings about their chronic disease, the impact on therapies, and their future expectations. cache = ./cache/cord-274563-jimw6skv.txt txt = ./txt/cord-274563-jimw6skv.txt === reduce.pl bib === id = cord-274556-531jlpwr author = Li, Wenrui title = Impact of COVID-19 on Peripheral Arterial Disease Treatment date = 2020-06-02 pages = extension = .txt mime = text/plain words = 253 sentences = 23 flesch = 56 summary = key: cord-274556-531jlpwr title: Impact of COVID-19 on Peripheral Arterial Disease Treatment With the conditions of PAD patients getting more serious when they come to the hospital, it is necessary to choose appropriate treatment to control perioperative complications and mortality. Prior to this, it is more important for patients to maintain the medical treatment of PAD [3] . Also, continuity of follow-up is key [4] , it is necessary to evaluate the patient's condition through telephone and phone application (obtain pictures of the patient's ischemia limb), and urge them to go to hospital in time when the condition worsens. Finally, on the basis of controlling the covid-19 pandemic, daily medical activities should be resumed as soon as possible to provide reasonable treatment for more patients with PAD. Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia Thinking beyond the box: preparing for the end of COVID-19 outbreak in a vascular surgery department cache = ./cache/cord-274556-531jlpwr.txt txt = ./txt/cord-274556-531jlpwr.txt === reduce.pl bib === id = cord-274282-hvx5m2bx author = Liu, Yang title = Association between ages and clinical characteristics and outcomes of coronavirus disease 2019 date = 2020-04-27 pages = extension = .txt mime = text/plain words = 1540 sentences = 86 flesch = 53 summary = This study showed that clinical features and prognosis of the disease vary among patients of different ages and a thorough assessment of age may help clinicians worldwide to establish risk stratification for all COVID-19 patients. However, the ages related clinical characteristics, diseases courses and outcomes other than death in COVID-19 patients remain unclear. A unified observation endpoint date was set (March 7, 2020) in our study, primary outcome of the disease course and second outcome of respiratory failure rate for all COVID-19 patients in both groups were compared. In this study, we demonstrated that the clinical characteristics and outcomes of 221 COVID-19 patients were closely related to the different ages. In conclusion, the clinical features and prognosis of the disease vary among patients of different ages and a thorough assessment of age may help clinicians worldwide to establish risk stratification for all COVID-19 patients. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China cache = ./cache/cord-274282-hvx5m2bx.txt txt = ./txt/cord-274282-hvx5m2bx.txt === reduce.pl bib === id = cord-274121-3w6kc0c9 author = Ramiro, Sofia title = Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date = 2020-07-20 pages = extension = .txt mime = text/plain words = 5757 sentences = 267 flesch = 47 summary = Objectives To prospectively investigate in patients with severe coVid-19-associated cytokine storm syndrome (css) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. Objectives To prospectively investigate in patients with severe coVid-19-associated cytokine storm syndrome (css) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. ► A strategy involving a course of high-dose glucocorticoids, followed by tocilizumab if needed, has shown to accelerate respiratory recovery, lower hospital mortality and reduce the likelihood of invasive mechanical ventilation compared with supportive care only in COVID-19-associated CSS. cache = ./cache/cord-274121-3w6kc0c9.txt txt = ./txt/cord-274121-3w6kc0c9.txt === reduce.pl bib === id = cord-274779-0emfl1e5 author = Andrews, Jinsy A. title = Amyotrophic lateral sclerosis care and research in the United States during the COVID‐19 pandemic: Challenges and opportunities date = 2020-06-05 pages = extension = .txt mime = text/plain words = 1835 sentences = 113 flesch = 50 summary = Coronavirus disease 2019 has created unprecedented challenges for amyotrophic lateral sclerosis (ALS) clinical care and research in the United States. Most of the 133 sites surveyed between April 21, 2020 and May 1, 2020 are affiliated with academic medical centers in the United States, have multidisciplinary care teams, see large numbers of patients, and participate in a variety of ALS research studies, including clinical trials. The most commonly used measure of ALS progression in clinics and in trials, the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R), can be obtained reliably and easily over the phone or by telemedicine. The COVID-19 pandemic has created an unprecedented challenges to ALS clinical care and research. Our combined experiences of clinician-patient interactions during this pandemic will provide us with new paradigms that will likely improve the efficiency of clinical care and availability of research participation. cache = ./cache/cord-274779-0emfl1e5.txt txt = ./txt/cord-274779-0emfl1e5.txt === reduce.pl bib === id = cord-275041-fcdwitxy author = Ayerbe, Luis title = The association of treatment with hydroxychloroquine and hospital mortality in COVID-19 patients date = 2020-09-30 pages = extension = .txt mime = text/plain words = 3258 sentences = 171 flesch = 50 summary = The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with hydroxychloroquine, azithromycin, heparin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality. Using limited evidence and clinical experience, doctors have treated COVID-19 patients with different drugs to eliminate or reduce the presence of the virus, including hydroxychloroquine (HCQ) [9] [10] [11] [12] . The association between treatment with HCQ and mortality was examined with four different logistic regression models: model one was adjusted for age and gender; model two included age and gender, together with temperature > 37 °C, and saturation of oxygen < 90% on admission, which were both associated with mortality in an exploratory analysis; model three had all the variables previously mentioned together with treatment with azithromycin, steroids, heparin, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir; finally, to account for the change in clinical management during the study period, model four was adjusted for all the previously mentioned demographic, clinical severity measures, and drugs, together with a categorical variable for date of admission (before the 10th of March, 11-20th of March, 20-31st March, 1st-10th of April, and 11-20th of April). cache = ./cache/cord-275041-fcdwitxy.txt txt = ./txt/cord-275041-fcdwitxy.txt === reduce.pl bib === id = cord-274355-6hiutrct author = Satheesan, Manoj Kumar title = A numerical study of ventilation strategies for infection risk mitigation in general inpatient wards date = 2020-02-22 pages = extension = .txt mime = text/plain words = 4945 sentences = 274 flesch = 56 summary = This study investigates the transport mechanism and deposition patterns of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) within a typical six bedded general inpatient ward cubicle through numerical simulation. Although it is widely assumed that increasing the air change rate (ACH) can reduce infection risks, it was shown that the risk of exposure to pathogens could increase with an increased ventilation rate under certain circumstances BUILD SIMUL https://doi.org/10.1007/s12273-020-0623-4 Satheesan et al. As the number of research studies on ventilation systems for general inpatient wards with respect to air change rate and exhaust airflow rate is limited, this study evaluates the combined impacts of these two parameters on the airflow as well as infection risk distributions of droplet nuclei of size 0.167 μm (i.e. MERS-CoV) within an air-conditioned general inpatient ward cubicle. Furthermore, the randomness associated with particle deposition rates (r w , r c , and r f ) under different air change rate conditions can be attributed to the asymmetric airflow distribution patterns and locations of the infected patients. cache = ./cache/cord-274355-6hiutrct.txt txt = ./txt/cord-274355-6hiutrct.txt === reduce.pl bib === id = cord-274934-s8xppipe author = Gebbia, Vittorio title = Patients With Cancer and COVID-19: A WhatsApp Messenger-Based Survey of Patients’ Queries, Needs, Fears, and Actions Taken date = 2020-05-15 pages = extension = .txt mime = text/plain words = 3391 sentences = 185 flesch = 46 summary = PURPOSE: This descriptive investigation was undertaken at three oncology units to report queries, needs, and fears related to severe acute respiratory syndrome coronavirus 2 (COVID-19) of patients with cancer and to avoid uncontrolled treatment delays or withdrawal, behavioral mistakes, and panic. In this article, we report real-world data and a descriptive analysis of patients' needs and fears as well as of misinformation obtained through the WhatsApp instant messaging system (WM; Facebook, Menlo Park, CA) in daily practice during the COVID-19 pandemic. To better understand how patients talk and feel about this potential critical health CONTEXT Key Objective Are instant messaging systems useful to oncologists to care for patients with cancer and to mitigate their anxieties and fears during the severe acute respiratory syndrome coronavirus 2 (COVID-19) outbreak? Knowledge Generated The WhatsApp instant messaging system is a useful and rapid tool to inform and reassure patients with cancer and to facilitate patient triage in a real-word setting of the pandemic spread of COVID-19. cache = ./cache/cord-274934-s8xppipe.txt txt = ./txt/cord-274934-s8xppipe.txt === reduce.pl bib === id = cord-274324-obhrbxu4 author = Tian, Wenjie title = Predictors of mortality in hospitalized COVID‐19 patients: A systematic review and meta‐analysis date = 2020-05-22 pages = extension = .txt mime = text/plain words = 3017 sentences = 200 flesch = 48 summary = Our systematic review and meta-analysis of 14 published articles involving 4659 patients is the first to provide a comprehensive analysis of the demographic features, comorbidities, and laboratory abnormalities that are associated with mortality in COVID-19. In this meta-analysis, we found that baseline cardiometabolic disease and evidence of increased acute inflammation and end-organ damage (cardiac, renal, liver and hematologic) on admission were associated with increased risk of mortality due to COVID-19 infection. Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis Arterial hypertension and risk of death in patients with COVID-19 infection: systematic review and meta-analysis Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China cache = ./cache/cord-274324-obhrbxu4.txt txt = ./txt/cord-274324-obhrbxu4.txt === reduce.pl bib === id = cord-275110-safr9z37 author = Alexander, Paul Elias title = COVID-19 research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine date = 2020-04-21 pages = extension = .txt mime = text/plain words = 3337 sentences = 169 flesch = 45 summary = At this time, more than ever, the high-quality, robust, comparative evidence from ethical randomized controlled trials (RCTs) is urgently needed to assess patient-important outcomes, including mortality, morbidity, need for life support, safety, and toxicity, informing on the safe use of chloroquine or hydroxychloroquine (with and without azithromycin) in people with COVID-19. This issue of potential harmful effects and the urgent need for high-quality, methodologically robust studies also comes from a recent pre-publication (not yet peer-reviewed) of in vitro activity of hydroxychloroquine or chloroquine in combination with metformin (used in treatment of type 2 diabetes to lower blood sugar in humans) in mice (25) . The use of existing drug treatments such as chloroquine and hydroxychloroquine outside of current guidelines and recommendations may result in adverse effects, including serious illness and death, affect patients with other diseases who may benefit from its use, and hinder the ability to conduct clinical trials if there are high demands to sue these agents by clinicians and patients. cache = ./cache/cord-275110-safr9z37.txt txt = ./txt/cord-275110-safr9z37.txt === reduce.pl bib === id = cord-274860-7ec2jcoq author = Salazar, Eric title = Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date = 2020-11-04 pages = extension = .txt mime = text/plain words = 4738 sentences = 234 flesch = 47 summary = title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG We recently reported results from interim analysis of a propensity-score matched study suggesting that early treatment of COVID-19 patients with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG significantly decreases mortality. In the aggregate, the analysis confirms and extends our previous preliminary finding that transfusion of COVID-19 patients soon after hospitalization with high titer anti-spike protein RBD IgG present in convalescent plasma significantly reduces mortality. In our previous study, interim analysis revealed that, relative to matched controls, patients transfused with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG within 72 hrs of hospital admission had significantly reduced mortality at 28 days post-transfusion. The data confirm our previous findings that transfusion of patients soon after hospital admission with high titer anti-spike protein RBD IgG present in convalescent plasma significantly decreases mortality. cache = ./cache/cord-274860-7ec2jcoq.txt txt = ./txt/cord-274860-7ec2jcoq.txt === reduce.pl bib === id = cord-274802-7ioiwsd8 author = Varghese, Praveen Mathews title = Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies date = 2020-08-19 pages = extension = .txt mime = text/plain words = 19657 sentences = 1033 flesch = 42 summary = Proteomic and transcriptomic studies on bronchoalveolar lavage (BAL) samples from COVID-19 patients have also revealed considerable insights into the expression of SARS-CoV-2 receptors, co-receptors, immune responses, as well as risk factors for severe disease e.g. age and co-morbidities. Furthermore, treatment with a recombinant C5a antibody on 2 male COVID-19 patients aged 54 and 67 years showed significant benefit in suppressing complement hyperactivation, which contributes to the excessive immune response causing aggravated inflammatory lung injury, a hallmark of SARS-CoV-2 pathogenesis and lethality (242) . Consistent with endothelial injury, the significantly elevated levels of von Willebrand factor found in the patient with severe COVID-19 has led to the idea that the infection of the ACE2 expressing endothelium by SARS-CoV-2 induces injury and activates the complement , which sets up a feedback loop that maintains a state of inflammation (243, (268) (269) (270) . Initial clinical studies in China involving 100 SARS-CoV-2 infected patients, who were treated with Chloroquine, showed amelioration of pneumonia, shortened disease progression, increased resolution of lung lesions on CT, and a better virus-negative conversion (313, 314) . cache = ./cache/cord-274802-7ioiwsd8.txt txt = ./txt/cord-274802-7ioiwsd8.txt === reduce.pl bib === id = cord-275257-upj8mvzn author = Hwang, E. Shelley title = Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change date = 2020-06-14 pages = extension = .txt mime = text/plain words = 8495 sentences = 389 flesch = 40 summary = Perspectives are provided on: (1) maintaining a safe environment for surgical oncology care; (2) redirecting the multidisciplinary model to guide surgical decisions; (3) harnessing telemedicine to accommodate requisite physical distancing; (4) understanding interactions between SARS CoV-2 and cancer therapy; (5) considering the ethical impact of professional guidelines for surgery prioritization; and (6) advocating for our patients who require oncologic surgery in the midst of the COVID-19 pandemic. The panel provides perspectives on: (1) creating a safe environment for surgical oncology care, (2) redirecting the multidisciplinary model to guide surgical decisions, (3) harnessing telemedicine to accommodate requisite physical distancing, (4) understanding interactions between SARS CoV-2 and cancer therapy, (5) considering the ethical impact of professional guidelines for surgery prioritization, and (6) advocating for our patients who require oncologic surgery in the midst of the COVID-19 pandemic. cache = ./cache/cord-275257-upj8mvzn.txt txt = ./txt/cord-275257-upj8mvzn.txt === reduce.pl bib === id = cord-274871-jlquvz51 author = Nori, Priya title = Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge date = 2020-07-24 pages = extension = .txt mime = text/plain words = 2205 sentences = 132 flesch = 40 summary = title: Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge We observed bacterial or fungal coinfections in COVID-19 patients admitted between March 1 and April 18, 2020 (152 of 4,267, 3.6%). Few studies have addressed bacterial or fungal coinfections or the emergence of antimicrobial resistance in coronavirus disease 2019 (COVID-19) patients. Patient demographics, central venous catheter status, ICU status, mechanical ventilation status, imaging, laboratory results, administered antibiotics per days of therapy (DOT), and disposition (admitted, discharged, deceased) were obtained from the electronic medical record. We observed widespread empiric antibiotic use throughout the pandemic and clinically relevant bacterial and fungal coinfections in patients with advanced COVID-19 and multiple risk factors for nosocomial infection (mechanical ventilation, central venous catheters, treatment with corticosteroids or biologics, and prolonged hospitalization). 2,6 Moreover, 79% of coinfected patients received antibiotics in the 30 days preceding positive cultures and 98% received them during the index COVID-19 hospitalization. cache = ./cache/cord-274871-jlquvz51.txt txt = ./txt/cord-274871-jlquvz51.txt === reduce.pl bib === id = cord-275185-9br8lwma author = Zeng, Hao title = The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series date = 2020-10-06 pages = extension = .txt mime = text/plain words = 6613 sentences = 360 flesch = 53 summary = Following CP transfusion, six out of eight patients showed improved oxygen support status; chest CT indicated varying degrees of absorption of pulmonary lesions in six patients within 8 days; the viral load was decreased to a negative level in five patients who had the previous viremia; other laboratory parameters also tended to improve, including increased lymphocyte counts, decreased C-reactive protein, procalcitonin, and indicators for liver function. Herein, we performed a retrospective observational study involving eight critical or severe patients with COVID-19 from four designated hospitals in the southwest region of China, aiming to explore the potential efficacy and safety of CP therapy, and to provide more evidence for the quality control of donated plasma and reasonable clinical application of CP transfusion. 23 Assessing the effects of neutralizing activity of CP on the patients' clinical efficacy, we found that patients treated by CP with high NAT50 (>1:640) had more obvious improvement than patients receiving low NAT50 value (≤1:640) of CP, including shorter negative conservation time of viral RNA, and higher increment of IgG level after CP transfusion. cache = ./cache/cord-275185-9br8lwma.txt txt = ./txt/cord-275185-9br8lwma.txt === reduce.pl bib === id = cord-275260-xuhxqkyj author = Sardu, Celestino title = Hyperglycaemia on admission to hospital and COVID-19 date = 2020-07-06 pages = extension = .txt mime = text/plain words = 1203 sentences = 67 flesch = 46 summary = The analysis of the data obtained on a very large population (1317 patients) provided important information, highlighting a role for BMI in disease severity, but did not correctly interpret the data on the role of hyperglycaemia at admission to hospital. Moreover, increased plasma glucose on admission to hospital was associated with poorer outcomes in patients with mild, moderate and severe COVID-19 [2] [3] [4] . To investigate the role of early glycaemic control in the outcomes of patients with COVID-19, we studied 132 consecutive hospitalised hyperglycaemic patients with moderate disease, admitted to Infectious diseases departments (Vanvitelli University, Naples Italy; San Sebastiano Caserta Hospital, Caserta, Italy). Fig. 1 (a) Blood glucose levels on admission to hospital and after 24 h for patients with (n = 60) and without severe disease (n = 72) at 20 days after hospitalisation. cache = ./cache/cord-275260-xuhxqkyj.txt txt = ./txt/cord-275260-xuhxqkyj.txt === reduce.pl bib === id = cord-275518-p03sl946 author = Borsa, Stefano title = Call of duty: neuro-oncology outpatient management during the COVID-19 pandemic in Milan, ITALY date = 2020-07-10 pages = extension = .txt mime = text/plain words = 752 sentences = 64 flesch = 62 summary = title: Call of duty: neuro-oncology outpatient management during the COVID-19 pandemic in Milan, ITALY Our hospital's neuro-oncological outpatient clinic is a tertiary center for brain tumor patients, with a regular workload of 15 patients/week. Since the SARS-CoV-2 outbreak reached the pandemic status, our hospital was identified as a COVID-19 referral center. Within the framework of the emergent plan re-organizing the regional health-care system, we were able to operate 3-4 patients with brain tumors per week and to guarantee neuro-oncological visits three times per week. As a further measure to limit the patients' accesses to the outpatient clinic, we encouraged the use of e-mails, telephone, and image-transfer tools to provide continuity of care. Such a multidisciplinary effort may enhance our response to the pandemic and contribute to the development of shared guidelines for modifying the approach to patients' follow-up, as it is already emerging in other medical fields 5 Neuro-oncology Management During the COVID-19 cache = ./cache/cord-275518-p03sl946.txt txt = ./txt/cord-275518-p03sl946.txt === reduce.pl bib === id = cord-275266-e6omvo5x author = Kort, Nanne P title = Resuming hip and knee arthroplasty after COVID-19: ethical implications for well-being, safety and the economy date = 2020-07-07 pages = extension = .txt mime = text/plain words = 5308 sentences = 259 flesch = 47 summary = 7, 8 These economic factors will influence the decision to re-start elective total joint Resuming hip and knee arthroplasty after COVID-19: ethical implications for well-being, safety and the economy arthroplasty during the COVID-19 pandemic. This specific, informed consent (IC) for elective surgery in times of COVID-19 requires further discussion with the patient about higher risk of virus transmission including from healthcare workers, the long incubation period (up to 14 days), the variable nature of the disease from mild to fatal, and discussions regarding ceilings of care and the potential need for ventilation. In this challenging time, when reinstating elective surgery in a risky scenario with limited resources, surgeons have the responsibility to follow a shared decision-making process with the patient that includes an understanding of the legal aspects of complications, and COVID-19 specific, informed consent. cache = ./cache/cord-275266-e6omvo5x.txt txt = ./txt/cord-275266-e6omvo5x.txt === reduce.pl bib === id = cord-275214-mqvw0219 author = Burlacu, Alexandru title = Is Thrombophilic Genetic Profile Responsible for an Acute Ischemic Stroke in a COVID-19 Male Patient? date = 2020-10-15 pages = extension = .txt mime = text/plain words = 1019 sentences = 70 flesch = 39 summary = title: Is Thrombophilic Genetic Profile Responsible for an Acute Ischemic Stroke in a COVID-19 Male Patient? presented a recent study (published in August 2020 in the Clinical and Applied Thrombosis/Hemostasis), a comprehensive review of the COVID-19 induced coagulopathy with its particular traits, the specificity of thromboembolic events and potential therapeutic interventions. In this particular context, the authors underline that the conventional clinical assessment of the risk of thrombotic events may not be efficient due to disease's particular evolution. Three days before the neurological event, the patient presented with mild respiratory symptoms erroneously interpreted as a non-COVID-19 pulmonary infection. We strongly suspect that subtle genetic risk factors for thrombotic events may influence the COVID-19 course, might hold the key to understanding the significant heterogeneity of COVID-19 manifestations, and may prove useful in assessing the COVID-19 patients' risk for thrombosis and severe disease. Unpuzzling COVID-19 prothrombotic state: are preexisting thrombophilic risk profiles responsible for heterogenous thrombotic events? cache = ./cache/cord-275214-mqvw0219.txt txt = ./txt/cord-275214-mqvw0219.txt === reduce.pl bib === id = cord-275004-qzg03dvg author = Veras, Flavio Protasio title = SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology date = 2020-09-14 pages = extension = .txt mime = text/plain words = 6380 sentences = 383 flesch = 51 summary = The concentration of NETs was augmented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neutrophils released higher levels of NETs. Notably, we found that viable SARS-CoV-2 can directly induce the release of NETs by healthy neutrophils. The well-known similarities between sepsis and key events involved in the COVID-19 pathophysiology, such as cytokine overproduction (Mehta et al., 2020) , microthrombosis (Magro et al., 2020; Dolhnikoff et al., 2020) , and acute respiratory distress syndrome (Lai et al., 2020) , led us to hypothesize that NETs are triggered during SARS-CoV-2 infection and might contribute to tissue injury in COVID-19 patients. In summary, in the present study, we demonstrated that in COVID-19 patients, circulating and lung-infiltrating neutrophils are releasing higher levels of NETs. We also showed that SARS-CoV-2 directly stimulates neutrophils to release NETs in mechanisms dependent on ACE2 and serine protease activity axis and effective viral replication. cache = ./cache/cord-275004-qzg03dvg.txt txt = ./txt/cord-275004-qzg03dvg.txt === reduce.pl bib === id = cord-275477-blu6wjhu author = Trimaille, Antonin title = COVID-19 et pathologie thromboembolique veineuse date = 2020-09-29 pages = extension = .txt mime = text/plain words = 2413 sentences = 227 flesch = 50 summary = Fréquence de la pathologie thrombo-embolique veineuse au cours des formes modérées de J o u r n a l P r e -p r o o f Dans une étude analyse une cohorte de 1240 patients consécutifs hospitalisés en dehors des services de Réanimation pour des formes modérées de COVID-19, les auteurs ont observé une incidence d'embolie pulmonaire confirmée à l'angioscanner de 8.3% (17) . En outre, il semble que les ETEV pourraient en partie survenir de manière asymptomatique au cours de la COVID-19 dans la mesure où les études utilisant un screening systématique ont retrouvé des incidences d'ETEV allant jusqu'à près de 50% des patients hospitalisés avec formes modérées (22, 23) . Helms et al ont observé une incidence de complications thrombo-emboliques de 18 Ainsi, les patients hospitalisés pour une forme sévère de COVID-19, en service de réanimation, présentent des ETEV très fréquemment, potentialisant la sévérité de l'atteinte respiratoire. cache = ./cache/cord-275477-blu6wjhu.txt txt = ./txt/cord-275477-blu6wjhu.txt === reduce.pl bib === id = cord-275349-b35pt3mo author = Lenz, Heinz-Josef title = The Emergence of Baricitinib: A Story of Tortoises Versus Hares date = 2020-07-06 pages = extension = .txt mime = text/plain words = 1403 sentences = 63 flesch = 37 summary = The artificial intelligence algorithms predicted that baricitinib would inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of cells [2] , (an effect later confirmed in human liver spheroids) [3] , combined with its better-known anti-inflammatory properties. Consequently, the combined potential antiviral and anti-inflammatory effects of this dually acting drug could be ideal for halting the progression of the disease in hospitalized patients, when taken for a limited duration. This new paper in the journal extends the previous published reports of baricitinib treatment in mild-tomoderate COVID19 patients and provides further evidence that baricitinib could be a potential treatment for unwell hospitalized patients with this disease, independent of severity. One would be advised to remain vigilant of such signals reflecting thromboembolic or infection risk in randomized controlled trials testing a variety of immunomodulatory therapies in COVID-19 patients, either alone or in combination, especially in view of associations between clots and SARS-CoV-2 infection [10] . cache = ./cache/cord-275349-b35pt3mo.txt txt = ./txt/cord-275349-b35pt3mo.txt === reduce.pl bib === id = cord-276249-9opsg7p2 author = Roberto, Katrina T. title = Electroencephalographic findings in COVID-19 patients: A systematic review date = 2020-09-15 pages = extension = .txt mime = text/plain words = 3122 sentences = 186 flesch = 44 summary = Patients with critical medical illnesses are known to be at risk for neurological complications like seizures and status epilepticus; however, the evidence is substantially limited in the context of COVID-19 infection (3) . Thus, the objective of this study was to review the EEG findings in patients diagnosed with COVID-19 infection through a systematic review of published relevant articles. We considered case reports/series, cross-sectional and cohort studies that reported on descriptive EEG findings in patients diagnosed with COVID-19 infection. Other electroencephalographic findings reported in the available literature include isoelectric EEG consistent with brain death in two cases (1.1%) in one study and fast activity superimposed on slow waves in three patients (1.7%) (22, 23) . Although it is well known that critically ill patients are at high risk for seizures and Focal non-epileptic slowing is another EEG abnormality seen in a number of COVID-19 cases. EEG findings in acutely ill patients investigated for SARS-CoV2/COVID-19: a small case series preliminary report cache = ./cache/cord-276249-9opsg7p2.txt txt = ./txt/cord-276249-9opsg7p2.txt === reduce.pl bib === id = cord-275154-vwnpred5 author = Bermejo-Martin, Jesus F title = Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza date = 2009-12-11 pages = extension = .txt mime = text/plain words = 4648 sentences = 260 flesch = 48 summary = Conclusions While infection with the nvH1N1 induces a typical innate response in both mild and severe patients, severe disease with respiratory involvement is characterized by early secretion of Th17 and Th1 cytokines usually associated with cell mediated immunity but also commonly linked to the pathogenesis of autoimmune/inflammatory diseases. Conclusions While infection with the nvH1N1 induces a typical innate response in both mild and severe patients, severe disease with respiratory involvement is characterized by early secretion of Th17 and Th1 cytokines usually associated with cell mediated immunity but also commonly linked to the pathogenesis of autoimmune/inflammatory diseases. To determine if host immune responses play a potential role in the evolution of mild or severe nvH1N1 illness we performed an analysis of systemic chemokine and cytokine levels in serum from severe and mild nvH1N1 patients shortly following the onset of symptoms. cache = ./cache/cord-275154-vwnpred5.txt txt = ./txt/cord-275154-vwnpred5.txt === reduce.pl bib === id = cord-275340-q8d7rvnj author = Sun, JingKang title = Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 date = 2020-06-21 pages = extension = .txt mime = text/plain words = 6629 sentences = 285 flesch = 47 summary = CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells. ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; CQ, chloroquine; HCQ, hydroxychloroquine; CoVs, coronaviruses; MAPK, mitogen-activated protein kinase; MHC-II, major histocompatibility complex class II; TLR, toll-like receptor; cGAS, cyclic GMP-AMP synthase; IFN, interferon; IL, interleukin; TNF-α, tumor necrosis factor-α. The authors deemed that the anti-inflammatory effect of low-dose HCQ and the activity of inhibiting viral replication may have important significance in critically ill patients with COVID-19. cache = ./cache/cord-275340-q8d7rvnj.txt txt = ./txt/cord-275340-q8d7rvnj.txt === reduce.pl bib === id = cord-276241-4g6pa7kz author = Yurttaş, Berna title = Characteristics and outcomes of Behçet’s syndrome patients with Coronavirus Disease 2019: a case series of 10 patients date = 2020-07-09 pages = extension = .txt mime = text/plain words = 1735 sentences = 109 flesch = 54 summary = Recently two European centers reported that the prevalence of SARS-CoV-2 infection among patients with systemic autoimmune diseases was comparable to that observed in the general population [8, 9] . Table 2 shows presenting symptoms, laboratory tests, length of hospital stay and management related to COVID-19. Due to parenchymal CNS involvement with a progressive relapsing course, he received several immunosuppressive agents including cyclophosphamide and Case no 3, 4, 5 and 6 had been diagnosed with COVID-19 pneumonia. Our case series suggests that BS patients are much younger and appear to have increased risk for severe outcome when infected with COVID-19 compared to the general population. In line with our observations, very recently a study from Wuhan, China, reported that respiratory failure was more commonly observed in RD patients infected with COVID-19 compared to those without RD [15] . High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study cache = ./cache/cord-276241-4g6pa7kz.txt txt = ./txt/cord-276241-4g6pa7kz.txt === reduce.pl bib === id = cord-276132-tv5y1eqc author = Ray, Upasana title = COVID-19: The Impact in Oncology Care date = 2020-10-23 pages = extension = .txt mime = text/plain words = 5696 sentences = 243 flesch = 39 summary = The COVID-19 pandemic has imposed a critical challenge to the current oncology care and practices including late diagnoses, delayed anti-cancer treatment, and static clinical trials. Delaying anti-cancer treatment in the ongoing pandemic cannot be recommended as a sensible choice to reduce the associated infection risk in patients. The American Society of Clinical Oncology (ASCO) recommends that in cancer patients diagnosed with the infection, the immunosuppressive therapies should be withheld until the symptoms resolve like complete remission of fever without use of antipyretics along with a negative COVID-19 test. Nevertheless, contact limitation and physical distancing guidelines continue to be an important part of the cancer treatment strategies during the pandemic in order to protect the patients, health-care personnel and non-COVID-19 patients being treated in the same organization. A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan cache = ./cache/cord-276132-tv5y1eqc.txt txt = ./txt/cord-276132-tv5y1eqc.txt === reduce.pl bib === id = cord-275440-fl4dsu7d author = Turnidge, John title = Responsible Prescribing for Upper Respiratory Tract Infections date = 2012-10-10 pages = extension = .txt mime = text/plain words = 6473 sentences = 375 flesch = 45 summary = Generic strategies, including eliciting patient expectations, avoiding the term 'just a virus', providing a value-for-money consultation, providing verbal and written information, empowering patients, conditional prescribing, directed education campaigns, and emphasis on symptomatic treatments, should be used as well as discussion of alternative medicines when relevant. Detailed strategies for acute sinusitis have not been worked out but restricting antibacterial prescribing to certain clinical complexes is currently recommended by several authorities because of the high natural resolution rate. Given that resistance to antibacterials in the common bacterial respiratory pathogens, especially Streptococcus pneumoniae, is increasing worldwide, [5] it is time to critically review prescribing practices in patients with URTI and find methods for not prescribing antibacterials to patients who are unlikely to benefit. [27] There is a difference between the bacteriology of previously untreated acute otitis media and that of patients with persistent infection, [28] resistant bacteria being more common in the latter. cache = ./cache/cord-275440-fl4dsu7d.txt txt = ./txt/cord-275440-fl4dsu7d.txt === reduce.pl bib === id = cord-276264-wgzh3f5m author = Navlakha, S. title = Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning date = 2020-08-25 pages = extension = .txt mime = text/plain words = 4665 sentences = 322 flesch = 53 summary = Although previous studies have uncovered factors that increase risk of severe COVID-19 infection --e.g., older age, obesity, or pre-existing heart or lung disease [1] [2] [3] [4] --the clinical course and outcome of patients with COVID-19 illness remains variable and difficult for clinicians to predict. To help clinicians predict COVID-19 severity [5, 6] , we turned to robust machine learning methods to identify high-risk cancer patients based on their pre-existing conditions and initial clinical manifestations. In this study, we developed a model to predict clinical outcomes (level of oxygen support needed) in cancer patients, using only clinical variables that were available on or before COVID-19 diagnosis (called time zero). Previous machine learning studies have reported impressive performance predicting COVID-19 outcomes for non-cancer patients using only a few clinical variables. We used machine learning algorithms to identify clinical variables predictive of severe COVID-19 illness in cancer patients at time zero. cache = ./cache/cord-276264-wgzh3f5m.txt txt = ./txt/cord-276264-wgzh3f5m.txt === reduce.pl bib === id = cord-276288-upv2o8f6 author = Prior, Sarah Jane title = Person-centred data collection methods to embed the authentic voice of people who experience health challenges date = 2020-07-21 pages = extension = .txt mime = text/plain words = 3680 sentences = 189 flesch = 42 summary = The patient or consumer voice in healthcare has evolved from an aspiration to becoming an expectation, which in some developed countries is respected by inclusion in nationally auditable standards (Australian Commission on Safety and Quality in Health-Care. Understanding the characteristics of the population is key to ensuring appropriate representation of consumers in person-centred or patient involvement research methods. 4 Direct engagement of patients and other consumers in research and health service improvement activities requires careful methodological planning around desirability and feasibility and the practical implications for the involvement of patients and consumer as participants. 5 The following examples of person-centred research methods enable the authentic voice of individuals who experience health challenges to be collected. 11 Codesign using focus groups is an opportunity for patients and other consumers to consider and discuss their experiences within healthcare systems and services in a collaborative, participatory setting. cache = ./cache/cord-276288-upv2o8f6.txt txt = ./txt/cord-276288-upv2o8f6.txt === reduce.pl bib === id = cord-276090-n8c2jpr6 author = Patel, Hiren N. title = Cerebellar Infarction Requiring Surgical Decompression in patient with COVID 19 Pathological Analysis, Brief Review date = 2020-07-29 pages = extension = .txt mime = text/plain words = 2871 sentences = 162 flesch = 41 summary = CONCLUSION: A young man with COVID-19 and suspected immune dysregulation, complicated by a large cerebrovascular ischemic stroke secondary to vertebral artery thrombosis requiring emergent neurosurgical intervention for decompression with improved neurological outcomes. angiography, CXR denotes chest X-ray, FiO2 denotes fraction of inspired oxygen, SARS-COV-2 denotes severe acute respiratory syndrome coronavirus 2, STAT denotes statum which is Latin meaning immediately, t-PA denotes tissue plasminogen activator, WHO denotes World Health Organization. A young man with COVID-19 and suspected immune dysregulation, complicated by a large cerebrovascular ischemic stroke secondary to vertebral artery thrombosis requiring emergent neurosurgical intervention for decompression with improved neurological outcomes. COVID-19 complicated with cerebral and large vessel vasculitis and its treatment will require a need for randomized clinical trials showing benefit in outcomes and mortality. This is a report of a patient with COVID-19 immune dysregulation who developed an acute cerebellar ischemic stroke secondary to vertebral artery thrombosis. cache = ./cache/cord-276090-n8c2jpr6.txt txt = ./txt/cord-276090-n8c2jpr6.txt === reduce.pl bib === id = cord-275272-qdg8sqpy author = Soares-Júnior, José Maria title = Gynecology and women’s health care during the COVID-19 pandemic: Patient safety in surgery and prevention date = 2020-06-16 pages = extension = .txt mime = text/plain words = 2038 sentences = 132 flesch = 45 summary = In this context, based on a recent publication regarding patient safety in elective surgeries (9) (10) (11) , as well as on the law of access to treatment and laws related to women's health care (23, 24) , we propose the inclusion of gynecological surgery cases, stratified as follows ( Figure 1 ): Emergency (o1h): Peritonitis by tubo-ovarian and/or pelvic abscess, necrotizing fasciitis in surgeries for pelvic and breast neoplasms; DOI: 10.6061/clinics/2020/e2063 Urgent (o24h): Postoperative infections, acute inflammatory abdomen (adnexal tortoise, myoma tortoise, ovarian cysts), hemorrhagic conditions (ovarian cysts); Elective urgent (o2 weeks): Surgeries for neoplasms of the lower genital tract and breast previously diagnosed by pathological examination; Essential Elective (42 to o3 months): Hysteroscopy for abnormal uterine bleeding (unknowledge causes, suspected malignancy, and menopausal transition), postmenopausal bleeding (suspected malignancy), cervical conization or looped electro excision procedure (to exclude neoplasm in the lower genital tract); Non-essential/elective surgery: Infertility procedures, family planning procedures (bilateral tubal ligation procedure). cache = ./cache/cord-275272-qdg8sqpy.txt txt = ./txt/cord-275272-qdg8sqpy.txt === reduce.pl bib === id = cord-276267-77903fld author = Al‐Ani, Aysha H. title = Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient date = 2020-05-26 pages = extension = .txt mime = text/plain words = 5481 sentences = 355 flesch = 42 summary = 6 Consequently, there is a concern that IBD patients are at greater risk of developing COVID-19 and at increased risk of progressing to a more severe clinical course or even death compared to the general population. 18 Furthermore, there is a recent case report of a possible SARS-CoV-2 gastrointestinal infection causing acute haemorrhagic colitis and signalling COVID-19 disease. Clinical assessment of risk factors for infection in inflammatory bowel disease patients Protection of 318 inflammatory bowel disease patients from the outbreak and rapid spread of COVID-19 infection in Wuhan Risk of infection with methotrexate therapy in inflammatory diseases: a systematic review and meta-analysis Comparative risk of serious infections with biologic and/or immunosuppressive therapy in patients with inflammatory bowel diseases: a systematic review and meta-analysis Infection-related hospitalizations are associated with increased mortality in patients with inflammatory bowel diseases Respiratory tract infections in patients with inflammatory bowel disease: safety analyses from vedolizumab clinical trials cache = ./cache/cord-276267-77903fld.txt txt = ./txt/cord-276267-77903fld.txt === reduce.pl bib === id = cord-275979-cx2h5bsw author = Scutelnic, Adrian title = Vascular Events, Vascular Disease and Vascular Risk Factors—Strongly Intertwined with COVID-19 date = 2020-10-08 pages = extension = .txt mime = text/plain words = 6747 sentences = 342 flesch = 46 summary = According to the INTERSTROKE study, the 10 most frequent modifiable vascular risk factors are arterial hypertension, physical inactivity, overweight, dyslipidaemia, smoking, unhealthy diet, cardiac pathologies, diabetes mellitus, stress/depression and overconsumption of alcohol. Also, a higher rate of infection with COVID-19, severe COVID-19 and bad outcome has been demonstrated in patients with pre-existing vascular disease and vascular risk factors. A higher rate of infection with COVID-19, severe COVID-19, and worse outcome has been demonstrated in patients with pre-existing vascular disease and risk factors, compared with young and healthy persons [1, 6, 8-11, 28, 29] . Several potential mechanisms increasing this risk of COVID-19 in patients with diabetes mellitus have been proposed: (1) higher affinity of cellular binding of SARS-CoV-2 and higher levels of circulating furin facilitating virus entry, (2) increased ACE2 expression in the lungs, (3) decreased viral clearance, (4) diminished T cell function, (5) increased susceptibility to inflammation and cytokine storm syndrome and (6) co-existence of vascular disease and risk factors [5] . cache = ./cache/cord-275979-cx2h5bsw.txt txt = ./txt/cord-275979-cx2h5bsw.txt === reduce.pl bib === id = cord-276303-lgywz9ea author = Rello, Jordi title = COVID-19, steroids and other immunomodulators: The jigsaw is not complete date = 2020-10-25 pages = extension = .txt mime = text/plain words = 1627 sentences = 80 flesch = 46 summary = Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial cache = ./cache/cord-276303-lgywz9ea.txt txt = ./txt/cord-276303-lgywz9ea.txt === reduce.pl bib === id = cord-276359-syr9av09 author = Piva, Simone title = Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy date = 2020-04-14 pages = extension = .txt mime = text/plain words = 3312 sentences = 204 flesch = 49 summary = title: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy In addition to describing the clinical management of such patients, this study details a proposed severity scale that was used to communicate with non-intensivists for management and triage, and for a step-up approach to drug therapy including antivirals, desamethasone and selective cytokine blockers. Creation of a severity scale to assess patients with COVID is of value to hospitals and physicians facing such shortages. The pandemic spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease, COVID-19, has resulted in massive strain in healthcare systems in several countries. The experience of Lombardy is interesting in that despite Italy having the third most number of ICU beds per capita, after the United States and Germany, physicians have had to limit resources due to shortages [1] . cache = ./cache/cord-276359-syr9av09.txt txt = ./txt/cord-276359-syr9av09.txt === reduce.pl bib === id = cord-276234-2nkeq4ud author = Siedlecki, Jakob title = COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic date = 2020-05-06 pages = extension = .txt mime = text/plain words = 3702 sentences = 227 flesch = 46 summary = Indeed, ophthalmologists seem to rank among the medical specialties with the highest risk for COVID-19 infection, probably due to close patient contact during examination, e.g., at the slit lamp [4] , and possible conjunctival involvement during the course of the disease [5, 6] . In this paper, a systematic review of current COVID-19 literature relevant for ophthalmological practice is performed, with a special focus on modes of transmission, the prevention thereof, structural adjustments of clinical care required during the pandemic, and possible ocular manifestations of this novel disease. The novel coronavirus SARS-CoV 2, currently causing the COVID-19 pandemic, has severe implications for ophthalmologybe it because the eyes represent an important route of infection, most probably through lacrimal drainage into the nasal mucosa, or because of ocular manifestations, which, even if rather rare, can represent the first symptoms of this novel disease [29] . cache = ./cache/cord-276234-2nkeq4ud.txt txt = ./txt/cord-276234-2nkeq4ud.txt === reduce.pl bib === id = cord-276524-th6eu11h author = Atallah, Bassam title = Thrombotic events following tocilizumab therapy in critically ill COVID-19 patients: a Façade for prognostic markers date = 2020-09-09 pages = extension = .txt mime = text/plain words = 2630 sentences = 141 flesch = 42 summary = His D-dimer was over 6 times the upper limit of normal (ULN) and started on intensified prophylaxis with unfractionated heparin infusion (UFH) 7500 units TID per our COVID anticoagulation protocol [4] . D-dimer was over 6 times ULN on transfer: Patient was directly placed on high intensity thromboprophylaxis with heparin 7500 SC TID and received tocilizumab on second day of admission. Additionally, the fact that thrombotic events continued to be observed despite decrease in inflammatory markers and the proactive anticoagulative approach adopted, raises more questions about the coagulative mechanisms at play in COVID-19, and the appropriate management strategy. Additionally, the fact that thrombotic events continued to be observed despite decrease in inflammatory markers and the proactive anticoagulative approach adopted, raises more questions about the coagulative mechanisms at play in COVID-19, and the appropriate management strategy. cache = ./cache/cord-276524-th6eu11h.txt txt = ./txt/cord-276524-th6eu11h.txt === reduce.pl bib === id = cord-275506-3t5gf66c author = Agbuduwe, Charles title = Hematolological Manifestations of COVID‐19: From Cytopenia to Coagulopathy date = 2020-07-14 pages = extension = .txt mime = text/plain words = 4280 sentences = 265 flesch = 39 summary = [45] A retrospective study of COVID-19 patients admitted to ICU identified DVT in 25% with advanced age, lower lymphocyte counts and elevated D-dimers being significant risk factors. [63] Currently, the evidence base for the clinical management of COVID-19 is mostly limited to case series and other relatively small observational studies of hospitalised patients. Similar to findings in SARS patients, [64] lymphopenia is the most commonly reported hematological abnormality in COVID-19 and recent data shows that it can be predictive of disease severity. The use of convalescent plasma may, in addition, provide neutralising antibodies against SARS-CoV-2 and a small-scale clinical trial has reported modest but encouraging results in severely-ill but not in critical COVID-19 patients. In view of the increased thrombotic risk associated with COVID-19, prophylactic anticoagulation with low Accepted Article molecular weight heparin is recommended for all hospitalised patients with the disease and clinical trials are needed to investigate the role of more intensive anticoagulation and other experimental therapies. cache = ./cache/cord-275506-3t5gf66c.txt txt = ./txt/cord-275506-3t5gf66c.txt === reduce.pl bib === id = cord-275742-7jxt6diq author = Batarseh, Feras A. title = Preventive healthcare policies in the US: solutions for disease management using Big Data Analytics date = 2020-06-23 pages = extension = .txt mime = text/plain words = 7208 sentences = 424 flesch = 55 summary = Our work's main objective (hypothesis) is two-tier: through one of the largest and most representative national health datasets for population-based surveillance, data imputations and machine learning models (such as clustering) offer preventive care pointers by grouping patients into heterogeneous clusters, and providing data-driven predictions and policies for healthcare in the US. The Center for Disease Control and Prevention (CDC) reported on those states, and presented multiple cases to help increase public trust in immunizations: "We hope this report is a reminder to healthcare professionals to make a strong vaccine recommendation to their patients at every visit and make sure parents understand how important it is for their children to get all their recommended vaccinations on time" [5, 8] . 2. We aim to collect more CDC data variables to provide more correlations and further tests for imputations, and compare with other NHANES predictive models for specific diseases such as periodontitis [39] . cache = ./cache/cord-275742-7jxt6diq.txt txt = ./txt/cord-275742-7jxt6diq.txt === reduce.pl bib === id = cord-276405-yfvu83r9 author = Brat, Gabriel A. title = International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium date = 2020-08-19 pages = extension = .txt mime = text/plain words = 5729 sentences = 285 flesch = 46 summary = Because EHRs are not themselves agile analytic platforms, we have been successfully building upon the open source and free i2b2 (for Informatics for Integrating Biology and the Bedside) toolkit [10] [11] [12] [13] [14] [15] [16] [17] to manage, compute, and share data extracted from EHRs. In response to COVID-19, we have organized a global community of researchers, most of whom are or have been members of the i2b2 Academic Users Group, to rapidly set up an ad hoc network that can begin to answer some of the clinical and epidemiological questions around COVID-19 through data harmonization, analytics, and visualizations. Laboratory value trajectories Our initial data extraction included 14 laboratory markers of cardiac, renal, hepatic, and immune dysfunction that have been strongly associated with poor outcomes in COVID-19 patients in previous publications. cache = ./cache/cord-276405-yfvu83r9.txt txt = ./txt/cord-276405-yfvu83r9.txt === reduce.pl bib === id = cord-276438-nynri6my author = Lu, Jiade J. title = Experience of a Radiation Oncology Center Operating During the COVID-19 Outbreak date = 2020-04-10 pages = extension = .txt mime = text/plain words = 1544 sentences = 70 flesch = 48 summary = As the executive vice president of the Shanghai Proton and Heavy Ion Center (SPHIC), a tertiary cancer treatment facility on the front line against the COVID-19 epidemic responsible for patient care and infection control, our experience and opinions might be helpful for colleagues in the United States as a reference. Anyone with a body temperature over 37.3 o C and pertinent contact/travel history is transferred to a fever clinic at a designated hospital (special clinics of major general hospitals established during the 2003 SARS epidemic to triage and treat patients with fever) to rule out COVID-19 infection. From a professional point of view, I do not think it is necessary to delay chemotherapy or radiation treatment for patients with cancer because of COVID-19, unless an infection is confirmed or highly suspected or there are other medical reasons. Except for head and neck cancer treatments, all patients are required to wear a surgical mask during transportation and radiation therapy. cache = ./cache/cord-276438-nynri6my.txt txt = ./txt/cord-276438-nynri6my.txt === reduce.pl bib === id = cord-276343-sb3vd7fq author = Humar, Atul title = Assessment of Adenovirus Infection in Adult Lung Transplant Recipients Using Molecular Surveillance date = 2006-12-31 pages = extension = .txt mime = text/plain words = 3526 sentences = 211 flesch = 45 summary = [5] [6] [7] [8] Overall, lung transplant recipients with adenovirus infection appear to be at high risk for severe necrotizing pneumonitis, resulting in significant graft dysfunction and associated with high mortality. 9, 10 Infection of the allograft by adenovirus has also been associated with acute and chronic rejection and graft dysfunction in studies of lung and heart transplant recipients. 11, 12 However, recent data have suggested that adenovirus re-activation and viremia may be relatively common in transplant recipients and, in most cases, may not be associated with adverse clinical sequelae, especially if there is no evidence of allograft infection. In patients with detectable adenovirus viremia by PCR, clinical disease was attributed to adenovirus if detectable viremia was accompanied by compatible symptoms (including febrile illnesses, respiratory, gastrointestinal disease or evidence of infection of the allograft) in the absence of another defined etiology. cache = ./cache/cord-276343-sb3vd7fq.txt txt = ./txt/cord-276343-sb3vd7fq.txt === reduce.pl bib === id = cord-275913-85u6v3ib author = Bauernschmitt, Robert title = Valve-in-valve transcatheter aortic valve replacement in a young patient with a suspected COVID-19 infection: a surgical dilemma in the era of the COVID-19 pandemic date = 2020-06-08 pages = extension = .txt mime = text/plain words = 1076 sentences = 55 flesch = 43 summary = On admission, the patient underwent a computed tomography scan which demonstrated interstitial infiltration in the left lung, highly suspicious for a COVID-19 infection that could not be confirmed by reverse transcription polymerase chain reaction (RT-PCR) testing. We decided to perform transcatheter aortic valve replacement to avoid cardiopulmonary bypass with shorter operative times, presumably shorter ventilation times and duration of intensive care unit stay, and thus a lesser risk for pulmonary complications. Following discussion in the local heart team and with the consent of the patient, we decided to perform valve-in-valve transcatheter aortic valve replacement (TAVR) to prevent the potential complications of a prolonged reroot-replacement with its long operative and cardiopulmonary bypass times, which could lead to an increased time on the respirator in the ICU. Figure 1: Computed tomography scan on admission with interstitial infiltration highly suspicious for a COVID-19 infection. cache = ./cache/cord-275913-85u6v3ib.txt txt = ./txt/cord-275913-85u6v3ib.txt === reduce.pl bib === id = cord-276495-q22jnkn2 author = Belizário, José Ernesto title = Trained innate immunity, COVID-19 therapeutic dilemma, and fake science date = 2020-07-06 pages = extension = .txt mime = text/plain words = 2769 sentences = 132 flesch = 44 summary = This type of immunological memory or epigenetic programming to a pre-activated state allows the generation of a sustained and more effective non-specific response, even after years, although in the protocols of these studies, the innate immunity was evaluated after 3 months (2). Various clinical trials are underway to evaluate trained immunity through BCG vaccination in healthy volunteers under the coordination of Dr. Mihail Netea (Radboud University Medical Center, Nijmegen, the Netherlands). To our knowledge, there are no published articles or clinical evidences that show that BCG immunization protects against SARS-CoV-2 in Brazil. The journal The Lancet, in May 2020, published the results of an observational, longitudinal, and retrospective clinical study based on medical records of COVID-19 patient cohorts treated across 6 countries and 671 hospitals, with different technical capabilities and diverse drug protocols (13) . cache = ./cache/cord-276495-q22jnkn2.txt txt = ./txt/cord-276495-q22jnkn2.txt === reduce.pl bib === id = cord-276635-0ciy732e author = Nijjer, Sukhjinder Singh title = Optimal management of acute coronary syndromes in the era of COVID-19 date = 2020-09-02 pages = extension = .txt mime = text/plain words = 4483 sentences = 279 flesch = 48 summary = While PPCI remains the treatment of choice for STEMI, the number of COVID-19 cases in Wuhan and Lombardy raised sufficient concerns that thrombolysis should be considered in certain circumstances. Low-risk patients with low Global Registry of Acute Coronary Events (GRACE) scores and small troponin-rises can be stratified, and if appropriate, then early urgent angiography can be considered on an 'outpatient' basis without inpatient stays. The treatment for ACS is well established, and while Key points ► Prompt and early revascularisation, with appropriate personal protective equipment, remains the default treatment approach for patients with acute coronary syndrome in the COVID-19 era. ► Critically unwell patients with ST-elevation myocardial infarction, without onsite catheter lab facilities or too unstable for transfer should be considered for thrombolysis and activation of services for facilitated PCI if necessary. Effect of the COVID-19 pandemic on ST-segment-elevation myocardial infarction presentations and in-hospital outcomes cache = ./cache/cord-276635-0ciy732e.txt txt = ./txt/cord-276635-0ciy732e.txt === reduce.pl bib === id = cord-276327-wyevh4xv author = Sheng, Calvin C title = Canakinumab to reduce deterioration of cardiac and respiratory function in SARS‐CoV‐2 associated myocardial injury with heightened inflammation (canakinumab in Covid‐19 cardiac injury: The three C study) date = 2020-08-24 pages = extension = .txt mime = text/plain words = 3239 sentences = 192 flesch = 37 summary = We designed a proof‐of‐concept randomized controlled trial to evaluate whether treatment with canakinumab prevents progressive respiratory failure and worsening cardiac dysfunction in patients with SARS‐CoV2 infection, myocardial injury, and high levels of inflammation. The three C Study is a prospective, IRB approved, blinded randomized-controlled Phase II study designed to evaluate whether treatment with canakinumab prevents progressive heart and respiratory failure in patients with Covid-19 associated myocardial injury and increased inflammation. This blinded randomized controlled trial is designed as a proof of concept study to demonstrate whether IL-1β antagonism can dampen the deleterious autoinflammatory response to SARS-CoV2 infection in patients with myocardial injury and heightened inflammation. In evaluating this hypothesis, the Three C study will help inform whether targeting inappropriate activation of the innate immune system should be investigated in larger clinical trials to improve survival in patients with Covid-19 and myocardial injury. cache = ./cache/cord-276327-wyevh4xv.txt txt = ./txt/cord-276327-wyevh4xv.txt === reduce.pl bib === id = cord-276676-lgt0rzob author = Moka, Eleni title = Best Practice in Cardiac Anesthesia during the COVID-19 Pandemic: Practical Recommendations date = 2020-07-03 pages = extension = .txt mime = text/plain words = 5882 sentences = 274 flesch = 35 summary = Indeed, the pandemic has already affected cardiac surgery units in multiple ways: limited number of available ICU beds and ventilation sites, necessity to postpone or cancel elective and/or complex cardiac interventional procedures, patients developing COVID-19 post cardiac surgery, coronavirus patients necessitating urgent cardiac operations, cardiac anesthetists' in-hospital transfer to staff and support ICUs in front of the pandemic, infected health care providers with consequent shortage of medical and nursing practitioners, restrictions in clinical meetings, and cancelation of training and continuing medical education [6, 8] . Based on the current understanding of COVID-19 pathophysiology and the clinical characteristics of cardiovascular surgical patients, in this review, the authors highlight related anesthesia concerns and provide practical recommendations in reference to perioperative planning and management of patients undergoing cardiac surgery, along with a focus on disease control and prevention in the times of COVID-19 outbreak. cache = ./cache/cord-276676-lgt0rzob.txt txt = ./txt/cord-276676-lgt0rzob.txt === reduce.pl bib === id = cord-276856-88d3vzbs author = Petersen, Lonnie G. title = Single ventilator for multiple patients during COVID19 surge: matching and balancing patients date = 2020-06-18 pages = extension = .txt mime = text/plain words = 644 sentences = 46 flesch = 53 summary = title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients With a potential COVID19-induced ventilator shortage, supporting multiple patients on a single ventilator seems a simple solution to maximize resources. Beyond cross-contamination and increased dead space, matching patients to ensure appropriate individual ventilation peak pressures (P peak ), tidal volumes (V tidal ), and positive endexpiratory pressures (PEEP) is a concern, especially given the dynamic clinical presentation of the COVID19 patients with complicated acute respiratory distress syndrome (ARDS). One-way valves on both inspiratory and expiratory limbs ensured unidirectional flow, which both reduces functional dead space and the risk of crosscontamination between patient A and B, and seemingly also facilitated stable ventilation of B as A deteriorated. Finally, each class of ventilators requires a specific set up; if the method is considered, use the calm before the patient surge to familiarize, and ameliorate the many risks associated with sharing a ventilator. A single ventilator for multiple simulated patients to meet disaster surge cache = ./cache/cord-276856-88d3vzbs.txt txt = ./txt/cord-276856-88d3vzbs.txt === reduce.pl bib === id = cord-276621-9exp8e7h author = Jacobs, Jeremy M. title = Prolonged Mechanical Ventilation: Symptomatology, Well-Being, and Attitudes to Life date = 2020-09-06 pages = extension = .txt mime = text/plain words = 4430 sentences = 223 flesch = 48 summary = This study aims to describe the mood, well-being, distressing symptoms, and attitudes toward prolonged ventilation among PMV patients treated either at home or long-term acute care (LTAC). RESULTS: Participants were aged 61.7 ± 20.7 years, commonly suffered progressive neuromuscular disease (43.5%) or chronic lung disease (29%), were functionally dependent, treated at home (64.5%) or LTAC (35.5%), and had a mean PMV duration of 36.6 months (interquartile range 10.8-114.1). Although no significant differences were observed in the severity of the 10 r-ESAS subitem symptoms between home and LTAC, nonetheless, well-being was reported as asymptomatic or mildly impaired by 54% of home PMV patients compared with 26% among long-term care, with similar rates of severely impaired well-being reported by 10% and 11% of patients, respectively. cache = ./cache/cord-276621-9exp8e7h.txt txt = ./txt/cord-276621-9exp8e7h.txt === reduce.pl bib === id = cord-276927-rxudwp2v author = Barbas, Carmen Sílvia Valente title = Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome date = 2012-08-23 pages = extension = .txt mime = text/plain words = 7991 sentences = 374 flesch = 35 summary = Rapid administration of antibiotics and resuscitative measures in case of sepsis and septic shock associated with protective ventilatory strategies and early short-term paralysis associated with differential ventilatory techniques (recruitment maneuvers with adequate positive end-expiratory pressure titration, prone position, and new extracorporeal membrane oxygenation techniques) in severe ARDS can help improve its prognosis. Incorporation of modified risk factors such as acute increase of respiratory rate, presence of tachypnea, detection of pulse oximeter desaturation, increased necessity of oxygen supplementation, presence of low pH, acidosis, or hypoxemia in an arterial blood gas sample in clinical practice can improve the clinicians' ability to perform early diagnosis and prompt therapeutic intervention in ARDS [17] . cache = ./cache/cord-276927-rxudwp2v.txt txt = ./txt/cord-276927-rxudwp2v.txt === reduce.pl bib === id = cord-276782-3fpmatkb author = Garbey, M. title = A Model of Workflow in the Hospital During a Pandemic to Assist Management date = 2020-05-02 pages = extension = .txt mime = text/plain words = 5717 sentences = 295 flesch = 61 summary = The objective is to assist management in anticipating the load of each care unit, such as the ICU, or ordering supplies, such as personal protective equipment, but also to retrieve key parameters that measure the performance of the health system facing a new crisis. In some hospitals, the floor might be shared by patients who are 92 recovering from COVID-19 and palliative care patients.Despite this, we will separate 93 these functional units in our model to clarify the workflow process according to what 94 each patient stage requires in terms of resources and time to deliver adequate care. Number of Staff required at each care unit per beds in reference to the Workflow of Figure 1 Let us describe the data set we are using to construct our model. cache = ./cache/cord-276782-3fpmatkb.txt txt = ./txt/cord-276782-3fpmatkb.txt === reduce.pl bib === id = cord-276784-8lmg97zc author = Boziki, Marina Kleopatra title = COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated Demyelination date = 2020-06-04 pages = extension = .txt mime = text/plain words = 4769 sentences = 225 flesch = 33 summary = Moreover, the management of chronic neurological diseases, such as Multiple Sclerosis (MS), underwent guided modifications, such as an Extended Interval Dose (EID) of Disease-Modifying Treatment (DMT) administration, in order to minimize patients' exposure to the health system, thus reducing the risk of SARS-CoV-2 infection. In this review, we summarize existing evidence of key immune pathways that the SARS-CoV-2 modifies during COVID-19 and the relevant implication for MS and other autoimmune diseases with associated demyelination (such as Systemic lupus erythematosus and Antiphospholipid syndrome), including the context of potential neuroinvasion by SARS-Cov-2 and the alterations that DMT induces to the immune system. In this respect, the clinical implication of SARS-CoV-2 infection in PwMS needs to be carefully evaluated in long-term prospective studies that assess not only physical disability measurements but also cognition, patient-reported outcomes, and quality of life, thus aiming to elucidate COVID-19-related long-term effects on MS-related neurological status and beyond. cache = ./cache/cord-276784-8lmg97zc.txt txt = ./txt/cord-276784-8lmg97zc.txt === reduce.pl bib === id = cord-276834-20lcihf4 author = Idilman, Ilkay S. title = Lung and kidney perfusion deficits diagnosed by dual-energy computed tomography in patients with COVID-19-related systemic microangiopathy date = 2020-08-29 pages = extension = .txt mime = text/plain words = 4508 sentences = 249 flesch = 48 summary = title: Lung and kidney perfusion deficits diagnosed by dual-energy computed tomography in patients with COVID-19-related systemic microangiopathy We evaluated lung and kidney perfusion abnormalities in patients with COVID-19 by dual-energy computed tomography (DECT) and investigated the role of perfusion abnormalities on disease severity as a sign of microvascular obstruction. CONCLUSIONS: We found that a large proportion of patients with mild-to-moderate COVID-19 had PDs in their lungs and kidneys, which may be suggestive of the presence of systemic microangiopathy with micro-thrombosis. KEY POINTS: • Pulmonary perfusion abnormalities in COVID-19 patients, associated with disease severity, can be detected by pulmonary DECT. Here, we aimed to evaluate lung and kidney perfusion abnormalities in COVID-19 patients by dual-energy computed tomography (DECT) and to investigate the role of perfusion abnormalities on disease severity as a sign of microvascular obstruction. Perfused blood volume (PBV) images and iodine maps were generated using DECT post-processing software ("Lung PBV" and "Virtual unenhanced" in syngo Dual Energy; Siemens Healthineers) on a dedicated workstation. cache = ./cache/cord-276834-20lcihf4.txt txt = ./txt/cord-276834-20lcihf4.txt === reduce.pl bib === id = cord-276592-dsilwfl1 author = Chou, Calvin L title = How COVID-19 Disrupts—and Enhances—My Clinical Work date = 2020-04-08 pages = extension = .txt mime = text/plain words = 1381 sentences = 72 flesch = 61 summary = Now, in this new era of attention to hand hygiene and social distancing, I paranoically and abashedly attempt to reproduce the sterile technique I learned from my days in the basic science lab, expanding my alcohol wiping to doorknobs and surfaces throughout the medical center-indeed, to any possible hideout of renegade coronavirus. I have to remind myself to begin each virtual encounter with a warm hello, an explicitly stated wish that we could be meeting in person, a sound and lighting check, and a brief check-in with the patient about how they are coping with current public health recommendations. With this intentional centering, which takes a bit more effort than usual, I can hear that most of my patients describe anxiety about what they could or should do, and this response leads to prioritizing that concern on the list of topics that we collaboratively generate. He assents, and I ask, "What do you know of social distancing?" He says, "To tell you the truth, it doesn't make a lot of sense. cache = ./cache/cord-276592-dsilwfl1.txt txt = ./txt/cord-276592-dsilwfl1.txt === reduce.pl bib === id = cord-277189-fe8ego7f author = Szabados, Bernadett title = Clinical Characteristics and Outcome for Four SARS-CoV-2-infected Cancer Patients Treated with Immune Checkpoint Inhibitors date = 2020-05-26 pages = extension = .txt mime = text/plain words = 1698 sentences = 103 flesch = 50 summary = Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with higher mortality among cancer patients, particularly in those on systemic therapy. During this period, 11 patients (15%) developed symptoms consistent with coronavirus disease 2019 (COVID-19) and four (5%) tested positive. These data suggest that the higher risk of COVID-19 death associated with systemic therapy in cancer may not apply to patients on ICIs. Assessment of COVID-19 severity in these patients can be complicated by the underlying cancer and its treatment. Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 ) is associated with higher mortality among cancer patients [1] . Current data on COVID-19 mortality among cancer patients group treatment modalities such as immune therapy and targeted therapy (n = 7) together, which is flawed [3] . The fever and cough resolved 5 d later, and the patient resumed his cancer treatment after completion of his self-isolation period. cache = ./cache/cord-277189-fe8ego7f.txt txt = ./txt/cord-277189-fe8ego7f.txt === reduce.pl bib === id = cord-277096-zvb7n9wo author = Bond, David A. title = Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date = 2018-11-29 pages = extension = .txt mime = text/plain words = 3709 sentences = 179 flesch = 41 summary = 7 cHL is characterized by a relatively small proportion of pathologic Reed-Sternberg (RS) cells within a reactive inflammatory milieu and is associated with a state of increased Clinical Practice Points ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) is a widely used front-line regimen for the treatment of early and advanced stage classical Hodgkin lymphoma (cHL). We identified 3 patients experiencing febrile hypotensive reactions following ABVD chemotherapy at our institution with shared baseline clinical features, including stage IVB disease, high risk disease by International Prognostic Score, male gender, and Epstein-Barr virus-positive cHL. 15 Subsequent cases of fatal or life-threatening febrile, hypotensive reactions in patients with lymphoma treated with bleomycin as part of multi-agent therapy have been reported, [16] [17] [18] [19] including a patient with a febrile, hypotensive reaction following treatment with ABVD associated with tumor lysis syndrome (TLS) and markedly elevated serum IL-6. cache = ./cache/cord-277096-zvb7n9wo.txt txt = ./txt/cord-277096-zvb7n9wo.txt === reduce.pl bib === id = cord-277148-xzpuc22p author = Ammirati, Enrico title = UPDATE ON ACUTE MYOCARDITIS date = 2020-06-01 pages = extension = .txt mime = text/plain words = 5852 sentences = 280 flesch = 37 summary = Acute myocarditis (AM), a recent-onset inflammation of the heart, has heterogeneous clinical presentations, varying from minor symptoms to high-risk cardiac conditions with severe heart failure, refractory arrhythmias, and cardiogenic shock. In the last decade, the measurement of high-sensitive (hs) troponin levels for identifying myocardial injury and the use of cardiac magnetic resonance imaging (CMRI) for characterizing myocardial tissue changes, allowed to diagnose AM non-invasively and with reasonable accuracy, in a wider population of patients including low-risk subjects. Attention will be paid to contemporary outcomes and predictors of prognosis, the emerging entity of immune checkpoint inhibitors (ICI)-associated myocarditis, updated CMRI diagnostic criteria, new data on the use of temporary mechanical circulatory supports (MCS) in FM. Thus, simple factors such as clinical presentation, wide QRS, and reduced LVEF on admission can help identifying high-risk patients, in whom EMB is recommended to guide subsequent therapeutic strategies (e.g. search for specific etiologies or associated conditions, immunosuppressive regimen, short-term temporary MCS, and screening for HTx listing). cache = ./cache/cord-277148-xzpuc22p.txt txt = ./txt/cord-277148-xzpuc22p.txt === reduce.pl bib === id = cord-277260-7se220oz author = Gosain, Rohit title = COVID-19 and Cancer: a Comprehensive Review date = 2020-05-08 pages = extension = .txt mime = text/plain words = 5926 sentences = 306 flesch = 39 summary = Since the emergence of the first case in Wuhan, China, in December 2019, tremendous research efforts have been underway to understand the mechanisms of infectivity and transmissibility of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a fatal virus responsible for abysmal survival outcomes. Data from China thus far have shown that cancer patients infected with COVID-19 are at 3.5 times the risk of requiring mechanical ventilation or ICU admission, compared to the general population [9•] . The CALAVI trial will be initiated as a randomized global clinical trial to assess the potential of acalabrutinib in the treatment of the cytokine storm associated with severely ill COVID-19 patients [86] . An exploratory meta-analysis of 32 studies showed evidence of reduced mortality after receiving various doses of convalescent plasma in patients with severe acute respiratory infections of viral etiology [92] . Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China cache = ./cache/cord-277260-7se220oz.txt txt = ./txt/cord-277260-7se220oz.txt === reduce.pl bib === id = cord-277014-iz8jo44e author = Hu, Weihua title = Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study date = 2020-10-16 pages = extension = .txt mime = text/plain words = 3643 sentences = 202 flesch = 43 summary = This study indicates that severity of the disease, the length of stay in the hospital of surviving patients, and mortality were higher among COVID-19 patients with sodium balance disorders. CONCLUSION: Sodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with COVID-19 in Hubei, China, and it is associated with a higher risk of severe illness and increased in-hospital mortality. reported hyponatremia to be much common (50%) amongst hospitalized COVID-19 patients in the United States [13] , and recently study further suggested that serum sodium concentration was inversely correlated with IL-6, and hyponatremia was associated with a more severe outcome of COVID-19 disease [14] . The associative disorders of serum sodium balance, their clinical characteristics, severity, and outcomes in SARS-CoV-2 infected patients have not been established. It was revealed that disease severity, the length of hospital stay for surviving patients, and mortality were high among COVID-19 patients with sodium balance disorders. cache = ./cache/cord-277014-iz8jo44e.txt txt = ./txt/cord-277014-iz8jo44e.txt === reduce.pl bib === id = cord-277328-9s8fwg1h author = Zhuang, Yuandi title = Dynamic changes on chest CT of COVID-19 patients with solitary pulmonary lesion in initial CT date = 2020-09-04 pages = extension = .txt mime = text/plain words = 3918 sentences = 217 flesch = 59 summary = RESULTS: 22 COVID-19 patients (11 males and 11 females, with an average age of 40.7 ± 10.3) developed a solitary pulmonary lesion within 4 days after the onset of symptoms, the peak time of CT score was about 11 days (with a median CT score of 6), and was discharged about 19 days. The inclusion criteria were as follows:(1) Patients with positive detection of SARS-CoV-2 in respiratory or blood specimens; (2) initial chest CT scan appearing as solitary lesion; (3) meeting the discharge criteria in the diagnosis and treatment of COVID-19 (trial 7th edition) published by the National Health Commission of the People's Republic of China [9] ; (4) patients underwent ≥ 3 chest CT scans before discharge, and CT imaging data were complete and accessible. Spearman rank correlation test was performed, because the discharge time and the peak CT score did not coincide with normal distribution and Spearman r and p values were provided in graphs the time of maximum lung lesions during hospitalization, among whom four were patients with severe COVID 19. cache = ./cache/cord-277328-9s8fwg1h.txt txt = ./txt/cord-277328-9s8fwg1h.txt === reduce.pl bib === id = cord-277535-u283k70i author = Vaja, Rakesh title = Drugs and the liver date = 2020-09-22 pages = extension = .txt mime = text/plain words = 4012 sentences = 239 flesch = 49 summary = Additionally, drugs can also modify how the liver functions and cause dysfunction or even failure of the organ both by a direct effect on the liver or by alteration in liver blood flow. Furthermore, once a patient has been recognized to be suffering with liver dysfunction or failure drug choice and dosing regime will need to be rationalized. After reading this article you should: C understand the mechanisms of drug metabolism by the liver C have an appreciation of alterations to drug choice and dosing regimens in patients with liver disease due to their altered pharmacokinetics C know the management of a patient with paracetamol overdose There are many different isoforms of CYP450, classified according to their amino acid sequencing into families, subfamilies and individual genes. NSAIDS are contraindicated for systemic use in most liver disease patients, because of increased bioavalibilty, the high risk of precipitating gastrointestinal bleeding and renal failure. cache = ./cache/cord-277535-u283k70i.txt txt = ./txt/cord-277535-u283k70i.txt === reduce.pl bib === id = cord-276641-40r4mitg author = Elkhouly, Enas A title = Should cancer treatment be continued during the COVID-19 pandemic? A single Egyptian institution experience date = 2020-07-23 pages = extension = .txt mime = text/plain words = 3109 sentences = 235 flesch = 60 summary = The aim of this article is based on the fact that the potential threat of COVID-19 to immunocompromised cancer patients as a result of their disease or the treatment delivered is thought to be significant, so it is of great importance to study the best measures to be used by oncology centres to prevent or limit the exposure of cancer patients to COVID-19 and to provide cancer treatment to patients in need, as safely and as correctly as possible. After the appearance of COVID-19 in Egypt, it should be a must to take a rapid action by MCOD, until the arrival of national strategies from higher authorities, so the outpatients were classified into two groups: Group 1 patients under follow-up either as control or hormonal therapy (HT) and Group 2 patients under active treatments (surgery, chemotherapy (ChT), radiotherapy (RT), biological therapy or immunotherapy) either as neoadjuvant or adjuvant treatment or for metastatic disease. cache = ./cache/cord-276641-40r4mitg.txt txt = ./txt/cord-276641-40r4mitg.txt === reduce.pl bib === id = cord-277539-xt2nt11e author = Kochhar, Anuraj Singh title = Dentistry during and after COVID-19 Pandemic: Pediatric Considerations date = 2020 pages = extension = .txt mime = text/plain words = 4502 sentences = 296 flesch = 50 summary = Despite the avalanche of information that has exploded in relation to this rapidly spreading disease, there is a lack of consolidated information to guide dentists regarding clinical management including precautions to take materials to use and postprocedure care, during and after the COVID-19 pandemic. This review aims to provide a comprehensive summary from the available literature on COVID-19, its insinuation in dentistry, recommendations that have been published, and the actual in-practice implications, so a plan can be formulated and adapted to the circumstances of each dental practice during the pandemic and the times to follow. The purpose of this review is to provide a comprehensive summary from the available literature on COVID-19, its insinuation in dentistry, recommendations that have been published, and the actual in-practice implications, so a plan of measures can be formulated and adapted according to the circumstances of each dental practice during the pandemic and the times to follow. cache = ./cache/cord-277539-xt2nt11e.txt txt = ./txt/cord-277539-xt2nt11e.txt === reduce.pl bib === id = cord-277201-jzjxsetx author = Mazo, Jahinover title = More than Just Pneumonia: Acute Pulmonary Embolism in Two Middle-Aged Patients with COVID-19 date = 2020-07-30 pages = extension = .txt mime = text/plain words = 2648 sentences = 141 flesch = 40 summary = We suspect that a prothrombotic inflammatory response provoked by coronavirus disease could be the culprit, acting as an additive effect on middle-aged patients with known risk factors for venous thromboembolism. In addition to coagulation factor abnormalities, other reported findings of increased D-dimers, ferritin, and lactate dehydrogenase further support the assertion that a prothrombotic response to the virus is driving the thromboembolic events among COVID-19 patients [9] . Severe COVID-19 infections have also been associated with an inflammatory prothrombotic state, also potentially playing a key role behind the increase in reported thromboembolic complications. We suspect that the existing risk factors present along with the superimposed prothrombotic state induced by COVID-19 induced inflammatory response may have precipitated the development of the venous thromboembolism resulting in PE. e CHEST Guideline and Expert Panel Report on management of venous thromboembolism (VTE) in COVID-19 patients outlines various recommendations for management of acute VTE. cache = ./cache/cord-277201-jzjxsetx.txt txt = ./txt/cord-277201-jzjxsetx.txt === reduce.pl bib === id = cord-277146-4a4vz36h author = Aggarwal, Mukul title = Hemostatic Abnormalities in COVID-19: An Update date = 2020-08-11 pages = extension = .txt mime = text/plain words = 4630 sentences = 271 flesch = 40 summary = Multiple reports have reported the presence of deranged parameters of coagulation in patients of In this review, we will discuss the various pathophysiological mechanisms leading to COVID-19 associated coagulopathy (CAC), derangement in laboratory parameters, incidence, and risk factors of venous thromboembolism (VTE) and prevention and treatment of CAC. Pulmonary Intravascular Coagulation, its Histopathological Evidence and Contribution of Cytokine Storm COVID-19 patients have been shown to have high levels of D-dimer [8, 9] but unlike patients of sepsis, they only have a mild prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT), mild thrombocytopenia [4, 9] . They recommend standard dose LMWH as most preferred agent followed by UFH then DOAC for acutely ill and critical hospitalized patients with COVID-19. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy cache = ./cache/cord-277146-4a4vz36h.txt txt = ./txt/cord-277146-4a4vz36h.txt === reduce.pl bib === id = cord-277498-hdhq99k2 author = Chua, Melvin L.K. title = Follow-up and management of head and neck cancer patients during the 2019 novel coronavirus (SARS-CoV-2) disease pandemic date = 2020-05-15 pages = extension = .txt mime = text/plain words = 3345 sentences = 158 flesch = 45 summary = title: Follow-up and management of head and neck cancer patients during the 2019 novel coronavirus (SARS-CoV-2) disease pandemic These scenarios would be considered high-risk for SARS-CoV-2 transmission, and the HCW consulting the patient would require full personal protection equipment (PPE) consisting of N95 mask, surgical gowns, gloves, and goggles/face shields 16 . Following the completion of treatment any patient with direct contact with a SARS-CoV-2 infected individual or who has personally tested positive or has symptoms of COVID-19 should not be seen in an oncology clinic for a follow-up visit. When it is challenging to distinguish between post-treatment edema and residual tumor on imaging, a detailed physical exam including endoscopy may be required, and as aforementioned, full PPE is required to protect the HCW from transmission of SARS-CoV-2 through aerosolization during NPL. Herein, we focused on the impact of this pandemic on the management of head and neck cancer patients who are undergoing or have completed radiation treatment. cache = ./cache/cord-277498-hdhq99k2.txt txt = ./txt/cord-277498-hdhq99k2.txt === reduce.pl bib === id = cord-277207-2my86ums author = Zhou, H. title = Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19) date = 2020-04-15 pages = extension = .txt mime = text/plain words = 3609 sentences = 234 flesch = 47 summary = We also presented bone marrow aspiration pathology of three patients with delayed phase thrombocytopenia, showing impaired maturation of megakaryocytes. There were two inclusion criteria for this study: (1) each patient was confirmed by real-time reverse transcription PCR (real-time RT-PCR) and were diagnosed as having COVID-19 according to WHO interim guidance [6] ; (2) all patients underwent chest computerized tomography (CT) and complete panel of routine laboratory tests, including compete blood count, blood biochemistry, blood coagulation function, test of key inflammatory cytokines (IL-4, IL-6, IL-10, IFN-γ, TNF-α), and lymphocytes subset analysis. We collected data on age, gender, respiratory rate, smoking and comorbidities (Hepatitis B, Hepatitis C, HIV, hepatosplenomegaly, hematological system disease, rheumatic immune system disease, cardio cerebrovascular disease, endocrine system disease, respiratory system disease, digestive system disease, nervous system disease and malignant tumor), symptoms from onset to hospital admission (fever, cough, dyspnea, pharyngalgia, diarrhea, anorexia, abdominal pain, palpitation, hypodynamia, paresthesia, myalgia and dizziness), laboratory values on admission (blood routine, blood coagulation function, blood biochemistry, C-reactive protein, inflammatory cytokines and lymphocyte Subsets ), treatment (antiviral agents, antibacterial agents, antifungal agents, corticosteroids, inhaled interferon-α, All rights reserved. cache = ./cache/cord-277207-2my86ums.txt txt = ./txt/cord-277207-2my86ums.txt === reduce.pl bib === id = cord-277576-3dvt6uj7 author = Demir, Erol title = COVID‐19 in kidney transplant recipients: A multicenter experience in Istanbul date = 2020-07-13 pages = extension = .txt mime = text/plain words = 2243 sentences = 169 flesch = 51 summary = INTRODUCTION: Management of COVID‐19 in kidney transplant recipients should include treatment of the infection, regulation of immunosuppression, and supportive therapy. MATERIAL AND METHODS: Kidney transplant recipients diagnosed with COVID‐19 from five major transplant centers in Istanbul, Turkey, were included in this retrospective cohort study. [1] [2] [3] [4] [5] [6] [7] Although uremia and kidney transplantation are not considered a risk factor in COVID-19, SARS-CoV-2 often causes a moderate or severe infection in kidney transplant recipients. Kidney transplant recipients diagnosed with COVID-19 from five major transplant centers in Istanbul, Turkey, were included in this retrospective cohort study. 2, 4, 5 To the best of our knowledge, the use of favipiravir and anakinra in the treatment of COVID-19 in kidney transplant recipients has not been previously reported. In conclusion, COVID-19 has been seen to more commonly cause moderate or severe pneumonia in kidney transplant recipients, possibly due to immunosuppressive therapy. cache = ./cache/cord-277576-3dvt6uj7.txt txt = ./txt/cord-277576-3dvt6uj7.txt === reduce.pl bib === id = cord-275828-c6d6nk7x author = Mikasa, Keiichi title = JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date = 2016-07-31 pages = extension = .txt mime = text/plain words = 39672 sentences = 2522 flesch = 42 summary = -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 1 g/twice a day or 2 g/once a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Cases of late-onset hospital-acquired pneumonia or ventilator-associated pneumonia in which the risk of resistant bacteria is high An antimicrobial drug with anti-pseudomonal activity that targets non-glucose-fermentative gram-negative rod should be administered [50, 51, 68] -To treat polymicrobial infection, the administration of an antimicrobial drug with an activity against obligate anaerobe is not always necessary [67, 70] . -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 2 g/once a day or 1 g/twice a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Late-onset hospital-acquired pneumonia or cases in which there is a risk of multi-drug-resistant bacteria In addition to the above pathogens, the involvement of non-glucose-fermentative gram negative bacteria or ESBLproducing enteric bacteria must be considered. For the treatment of immunodeficiency-/blood disease-related pneumonia in children, antimicrobial drug therapy should also be basically selected, considering causative microorganisms. cache = ./cache/cord-275828-c6d6nk7x.txt txt = ./txt/cord-275828-c6d6nk7x.txt === reduce.pl bib === id = cord-277700-nxm1jr0x author = Chassagnon, Guillaume title = AI-Driven CT-based quantification, staging and short-term outcome prediction of COVID-19 pneumonia date = 2020-04-22 pages = extension = .txt mime = text/plain words = 4879 sentences = 245 flesch = 49 summary = (i) Two independent cohorts with quantification based on ensemble 2D & 3D consensus neural networks reaching expert-level annotations on massive evaluation, (ii) Consensus-driven bio(imaging)-marker selection on the principle of prevalence across methods leading to variables highly-correlated with outcomes & (iii) Consensus of linear & non-linear classification methods for staging and prognosis reaching optimal performance (minimum discrepancy between training & testing). The approach relied on (i) a disease quantification solution that exploited 2D & 3D convolutional neural networks using an ensemble method, (ii) a biomarker discovery approach sought to determine the share space of features that are the most informative for staging & prognosis, & (iii) an ensemble robust supervised classification method to distinguish patients with severe vs non-severe short-term outcome and among severe patients those intubated and those who did not survive. cache = ./cache/cord-277700-nxm1jr0x.txt txt = ./txt/cord-277700-nxm1jr0x.txt === reduce.pl bib === id = cord-277399-0w8is9xm author = Esteves, Sandro C. title = SARS‐CoV‐2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services date = 2020-05-22 pages = extension = .txt mime = text/plain words = 4160 sentences = 216 flesch = 38 summary = The prolonged lockdown of health facilities providing non‐urgent gamete cryopreservation—as currently recommended by many reproductive medicine entities and regulatory authorities due to the SARS‐CoV‐2 pandemic will be detrimental for subgroups of male infertility patients. These groups include infertility patients (eg, azoospermic and cryptozoospermic) undergoing medical or surgical treatment to improve sperm quantity and quality, as well as males of reproductive age affected by inflammatory and systemic auto‐immune diseases who are about to start treatment with gonadotoxic drugs or who are under remission. Sperm banking should be considered in men with HH who respond to therapy, that is, have viable spermatozoa in the ejaculate, in particular, when the continuation of gonadotropin therapy during the SARS-CoV-2 pandemic is neither possible (eg, due to economic or logistic reasons), nor desired. We propose remedies to mitigate the consequences of a prolonged cessation of andrological services due to the SARS-CoV-2 pandemic to vulnerable subgroups of male infertility patients. cache = ./cache/cord-277399-0w8is9xm.txt txt = ./txt/cord-277399-0w8is9xm.txt === reduce.pl bib === id = cord-277430-x02u7oh0 author = Zhang, Hongyan title = Outcomes of novel coronavirus disease 2019 (COVID‐19) infection in 107 patients with cancer from Wuhan, China date = 2020-06-23 pages = extension = .txt mime = text/plain words = 3182 sentences = 157 flesch = 44 summary = Secondary analyses included the reporting of clinical presentation and outcomes based on the different cancer types, and the association between mortality due to COVID-19 and whether the patient was receiving ongoing active anticancer treatment (systemic therapy, local therapy, or a combination). 5, 16 Rather, in the current study cohort of 107 patients, we observed that active anticancer treatment within 1 month of a diagnosis of COVID-19 was associated with profound lymphopenia (median of 0.55 vs 1.05 for those on follow-up) and markedly elevated inflammatory markers of C-reactive protein (36.00 vs 27.40) and procalcitonin (0.17 vs 0.06). The results of the current study demonstrated the clinical characteristics and outcomes of COVID-19 in a large cohort of 107 patients with different cancer types, and suggested a high incidence of severe illness and case fatality rates compared with the community population. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. cache = ./cache/cord-277430-x02u7oh0.txt txt = ./txt/cord-277430-x02u7oh0.txt === reduce.pl bib === id = cord-277178-nbotxv35 author = Vindrola-Padros, C. title = Remote home monitoring (virtual wards) during the COVID-19 pandemic: a living systematic review date = 2020-10-09 pages = extension = .txt mime = text/plain words = 5044 sentences = 307 flesch = 51 summary = Objectives: The aim of this review was to analyse the implementation and impact of remote home monitoring models (virtual wards) during COVID-19, identifying their main components, processes of implementation, target patient populations, impact on outcomes, costs and lessons learnt. There is a paucity of published literature on the models of care developed to implement remote home monitoring across different healthcare contexts during the COVID-19 pandemic, the experiences of staff implementing these models and patients receiving care, the use of data for monitoring progress, resources required, as well as the impact of these models on clinical, process and economic outcomes. The included articles were analysed using a data extraction form developed in REDCap (Research Electronic Data Capture) that extracted data on: the design and general characteristics of the model, patient populations, main reported process and clinical outcomes and its potential economic impact. cache = ./cache/cord-277178-nbotxv35.txt txt = ./txt/cord-277178-nbotxv35.txt === reduce.pl bib === id = cord-277486-12uah5qi author = Kopp, Kristen title = Interdisciplinary Model for Scheduling Post-discharge Cardiopulmonary Care of Patients Following Severe and Critical SARS-CoV-2 (Coronavirus) Infection date = 2020-08-14 pages = extension = .txt mime = text/plain words = 3178 sentences = 146 flesch = 32 summary = As Covid-19 can severely implicate the respiratory and cardiovascular systems, potential pulmonary, and/or cardiovascular sequelae may be anticipated in patients following severe and critical SARS-CoV-2 infection meriting coordinated post-discharge management to identify residual effects and to mitigate potential worsening of pre-existing conditions. The WHO report Interim Guidance: Clinical Management of Covid 19, released 27 May 2020 however anticipates potential sequelae in patients with severe and critical SARS-CoV-2 infection following treatment with mechanical ventilation, sedation, and/or prolonged bed rest based on evidence from general critical care populations. A coordinated post-discharge care concept for patients surviving Covid-19 is therefore warranted to identify any cardiopulmonary sequelae and to mitigate possible worsening of preexisting disease following severe and critical SARS-Cov-2 infection. Short, intermediate and long-term effects following severe and critical SARS-CoV-2 infection are unknown, and significant sequelae may be expected, especially in patient populations experiencing ARDS, sepsis, and/or multiple organ dysfunction, as well as patients with exacerbation or progression of preexisting pulmonary or cardiovascular disease. cache = ./cache/cord-277486-12uah5qi.txt txt = ./txt/cord-277486-12uah5qi.txt === reduce.pl bib === id = cord-277323-jqr2hkv2 author = Thampi, Swapna title = Considerations for resuscitation and transfer of paediatric patients with COVID-19 date = 2020-04-27 pages = extension = .txt mime = text/plain words = 261 sentences = 27 flesch = 48 summary = key: cord-277323-jqr2hkv2 authors: Thampi, Swapna; Melvin Lee, Chang Chuan; Zhi Ng, Beatrice Hui; Anne Yap, Andrea Pek title: Considerations for resuscitation and transfer of paediatric patients with COVID-19 cord_uid: jqr2hkv2 Swapna Thampi 1* , Chang Chuan Melvin Lee 1 with severe and critical disease being more prevalent in younger children. 6 As the pandemic spreads, we will encounter more paediatric patients with COVID-19 disease who require resuscitation and transfer. A Novel Coronavirus from Patients with Pneumonia in China Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients cache = ./cache/cord-277323-jqr2hkv2.txt txt = ./txt/cord-277323-jqr2hkv2.txt === reduce.pl bib === id = cord-277210-xaj2623u author = Weinkove, Robert title = Managing haematology and oncology patients during the COVID‐19 pandemic: interim consensus guidance date = 2020-05-13 pages = extension = .txt mime = text/plain words = 6044 sentences = 315 flesch = 38 summary = • Adopt measures within cancer centres to reduce risk of nosocomial SARS-CoV-2 acquisition; support population-wide social distancing; reduce demand on acute services; ensure adequate staffing; and provide culturally safe care. Patients with cancer could be at elevated risk of severe COVID-19, while delivery of cancer therapies could be disrupted by quarantines, social distancing measures, and interruption of routine health care delivery by the pandemic. 38 Community spread of COVID-19 has the potential to diminish the donor pool, to threaten the capacity of cancer services to provide routine transfusion support, and to increase the risks that transfusion-dependent patients will come into contact with other individuals with SARS-CoV-2. We present interim guidance for clinicians caring for patients with cancer who may be particularly vulnerable both to severe COVID-19 and the potential impact of the pandemic on the provision of cancer investigations and treatment. cache = ./cache/cord-277210-xaj2623u.txt txt = ./txt/cord-277210-xaj2623u.txt === reduce.pl bib === id = cord-277818-8w15dz20 author = Jaichenco, Andre L. title = Infectious Disease Considerations for the Operating Room date = 2018-02-09 pages = extension = .txt mime = text/plain words = 9728 sentences = 528 flesch = 39 summary = Hand hygiene is a well-known and effective solution to the problem of bacterial transmission within and across patients and is considered the most important and cost-effective individual intervention in the prevention of health care–associated infections in children and health care providers Compliance with the current "5 moments" World Health Organization guidelines could make a major inroad into reducing provider hand and workspace contamination. These findings have clinical implications for the risk of colonization and subsequent HCIs-for example, SSIs. This calls attention to the need to develop and enforce strict hand hygiene guidelines for personnel who are providing anesthesia care, but more importantly the need to increase compliance with environmental disinfection of the OR (between cases and terminal cleaning), and to study further the directions of the spread of pathogens in the OR and anesthesia work areas. cache = ./cache/cord-277818-8w15dz20.txt txt = ./txt/cord-277818-8w15dz20.txt === reduce.pl bib === id = cord-277803-7p1qu2rf author = Rubino, Francesco title = Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery date = 2020-05-07 pages = extension = .txt mime = text/plain words = 6087 sentences = 284 flesch = 35 summary = Given the uncertainty regarding the effects and duration of the COVID-19 outbreak, combined with the progressive nature of obesity, diabetes, and related conditions, delaying bariatric and metabolic surgery could increase the risks for morbidity and mortality in surgical candidates. cache = ./cache/cord-277803-7p1qu2rf.txt txt = ./txt/cord-277803-7p1qu2rf.txt === reduce.pl bib === id = cord-277811-j58qvyum author = Mehrani, Hossein title = Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis date = 2011-01-07 pages = extension = .txt mime = text/plain words = 4086 sentences = 226 flesch = 51 summary = title: Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis Haptoglobin α1 chain isoforms (spots 21, 22 and 23) were only detected in the plasma of the severe lung diseases patients but were not detectable in healthy controls ( Figure 2B and 2C). In this study we present plasma proteome analysis of SM exposed patients compared to the healthy controls. In our recent study of BAL fluid proteomics patterns in SM exposed patients we also found that haptoglobin isoforms were significantly elevated in moderate and severe lung disease patients compared to mild and healthy controls [13] . In conclusion, this study complements our previous BAL fluid proteome analysis of patients exposed to SM gas which resulted in identification of number of differentially expressed proteins. Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis cache = ./cache/cord-277811-j58qvyum.txt txt = ./txt/cord-277811-j58qvyum.txt === reduce.pl bib === id = cord-278325-ykcd7d59 author = Cheung, Carmen Ka Man title = Coronavirus Disease 2019 (COVID-19): A Haematologist's Perspective date = 2020-07-28 pages = extension = .txt mime = text/plain words = 7672 sentences = 379 flesch = 39 summary = Two meta-analyses showed that a lower platelet count is associated with an increased risk of severe disease and mortality in patients with COVID-19 and may serve as a marker for progression of illness [53, 54] . Experience from previous SARS patients, caused by SARS-CoV-1, suggested that coronavirus could cause thrombocytopenia by direct viral infection of bone marrow haematopoietic stem cells via CD13 or CD66a, formation of auto-antibodies and immune complexes, disseminated intravascular coagulopathy (DIC), and consumption of platelet in lung epithelium [61, 62] . The International Society on Thrombosis and Haemostasis (ISTH) suggested all patients (including non-critically ill) who require hospital admission for COVID-19 infection should receive a prophylactic dose of LMWH unless contraindicated (Table 2 ) [102] . Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19 cache = ./cache/cord-278325-ykcd7d59.txt txt = ./txt/cord-278325-ykcd7d59.txt === reduce.pl bib === id = cord-276758-k2imddzr author = Siegel, Jane D. title = 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings date = 2007-12-07 pages = extension = .txt mime = text/plain words = 46228 sentences = 2479 flesch = 35 summary = Activities currently assigned to ICPs in response to emerging challenges include (1) surveillance and infection prevention at facilities other than acute care hospitals (eg, ambulatory clinics, day surgery centers, LTCFs, rehabilitation centers, home care); (2) oversight of employee health services related to infection prevention (eg, assessment of risk and administration of recommended treatment after exposure to infectious agents, tuberculosis screening, influenza vaccination, respiratory protection fit testing, and administration of other vaccines as indicated, such as smallpox vaccine in 2003); (3) preparedness planning for annual influenza outbreaks, pandemic influenza, SARS, and bioweapons attacks; (4) adherence monitoring for selected infection control practices; (5) oversight of risk assessment and implementation of prevention measures associated with construction and renovation; (6) prevention of transmission of MDROs; (7) evaluation of new medical products that could be associated with increased infection risk (eg, intravenous infusion materials); (8) communication with the public, facility staff, and state and local health departments concerning infection control-related issues; and (9) participation in local and multicenter research projects. cache = ./cache/cord-276758-k2imddzr.txt txt = ./txt/cord-276758-k2imddzr.txt === reduce.pl bib === id = cord-278477-9a7gmzz3 author = Huh, Kyungmin title = Impact of obesity, fasting plasma glucose level, blood pressure, and renal function on the severity of COVID-19: a matter of sexual dimorphism? date = 2020-10-21 pages = extension = .txt mime = text/plain words = 3233 sentences = 182 flesch = 53 summary = Aims This study aimed to assess whether body mass index (BMI), fasting plasma glucose (FPG) levels, blood pressure (BP), and kidney function were associated with the risk of severe disease or death in patients with COVID-19. To examine the association between baseline health status and the risk of severe disease in patients with COVID-19, we performed a case-control study, using data from the nationwide registry of COVID-19 cases and from the biennial health checkup database in South Korea. In the present study based on a nationwide COVID-19 registry combined with an independent regular health checkup data, the effect of FPG levels and eGFR on the risk of severe or fatal COVID-19 varied between sex and age groups. In our retrospective study using a nationwide health checkup database, high FPG levels and low eGFR were significantly associated with the risk of severe COVID-19 (including fatal illness among women. cache = ./cache/cord-278477-9a7gmzz3.txt txt = ./txt/cord-278477-9a7gmzz3.txt === reduce.pl bib === id = cord-278300-6cr9h7no author = Lu, X. title = Classification of COVID-19 in intensive care patients: towards rational and effective clinical triage date = 2020-04-11 pages = extension = .txt mime = text/plain words = 1271 sentences = 98 flesch = 46 summary = We aimed to bridge the gap between disease classification and clinical outcome in intensive care patients, data of which are scarce and such classification could help in individual evaluation and provide effective triage for treatment and management. We constructed a fully Bayesian latent variable model for integrative clustering of six data categories, including demographic information, symptoms, original comorbidities, vital signs, blood routine tests and inflammatory marker measurements. We identified four prognostic types of COVID-19 in intensive care patients, presenting a stepwise distribution in age, respiratory condition and inflammatory markers, suggesting the prognostic efficacy of these indicators. Little attention has been paid to the clinical characteristics and outcomes of intensive care patients with COVID-19, data of which are scarce but are of paramount importance to reduce mortality. We aimed to bridge the gap between disease classification and clinical outcome in intensive care patients, which could help in individual evaluation and provide effective triage for treatment and management. cache = ./cache/cord-278300-6cr9h7no.txt txt = ./txt/cord-278300-6cr9h7no.txt === reduce.pl bib === id = cord-277889-8u685f45 author = Costela-Ruiz, Víctor J. title = SARS-CoV-2 infection: the role of cytokines in COVID-19 disease date = 2020-06-02 pages = extension = .txt mime = text/plain words = 9212 sentences = 552 flesch = 49 summary = The majority of patients infected with COVID-19 have normal or reduced white cell counts and lymphocytopenia, and those with severe disease have shown significantly elevated levels of neutrophils, dimer-D, and urea in blood, with a continuing decrease in lymphocytes. detected elevated levels of the antagonistic receptor of IL-1 (IL-1Ra) in 14 severe cases of COVID-19, and this marker has been associated with increased viral load, loss of pulmonary function, lung damage, and mortality risk [55] . observed that its expression during infection with an influenza virus had negative effects on CD8 + memory T cells [71] .Various studies of COVID-19 patients have detected elevated IL-4 levels as part of the cytokine storm associated with severe respiratory symptoms [16, 17, 43, 72] . Elevated IL-17 levels have been reported in patients with SARS-CoV-2 as part of the cytokine storm [17] , and they have been associated with the viral load and disease severity [56] . cache = ./cache/cord-277889-8u685f45.txt txt = ./txt/cord-277889-8u685f45.txt === reduce.pl bib === id = cord-278549-br9rr713 author = Madanelo, M. title = The impact of the COVID‐19 pandemic on the utilization of emergency urological services date = 2020-05-14 pages = extension = .txt mime = text/plain words = 1717 sentences = 106 flesch = 54 summary = OBJECTIVES: To compare the number of patients attending the Urology ED of Centro Hospitalar Universitário do Porto (CHUP), as well as their demographic characteristics, the reasons for admission, the clinical severity under the Manchester triage system (MTS), and the need for emergency surgery or hospitalization, during the pandemic and the equivalent period in 2019. The aim of this study was to compare the number of patients who attended the Urology emergency ward of a Portuguese Tertiary Hospital -Centro Hospitalar Universitário do Porto (CHUP), as well as their demographic characteristics and the main causes of presentation to the ED, during the COVID-19 pandemic and the equivalent period at the previous year. During the COVID-19 pandemic, on the aforementioned dates, 46.4% fewer patients visited our urological emergency service compared with the homologous period of time one year ago (122 vs. However, significantly fewer female patients sought emergency urological services during the COVID-19 pandemic period (32.7% vs. cache = ./cache/cord-278549-br9rr713.txt txt = ./txt/cord-278549-br9rr713.txt === reduce.pl bib === id = cord-278364-58d8kfdf author = Mohapatra, S. title = Sterilization and Disinfection date = 2017-03-31 pages = extension = .txt mime = text/plain words = 6548 sentences = 434 flesch = 49 summary = The medical device or the surgical instrument that comes in contact with the sterile tissue or the mucus membrane of the patient during the various processes is associated with increased risk of introduction of pathogens into the patient's body. Moreover, there is chance of transmission of infection from patient to patient; from patient or to health care personnel, and vice versa; or from the environment to the patient through the improper sterilized or disinfected devices. Patients care equipment are divided into three categories (critical, semicritical, and noncritical) depending on the intended use and risk of transmission of infection. These items do not need sterilization; however, they should be regularly cleaned and disinfected with LLD to decrease the transmission of infective organisms (Table 59 .6). Various recommendations for the prevention of VAP include (1) appropriate cleaning, disinfection, and sterilization of ventilator equipment, (2) maintenance of ventilator circuits, and (3) routine care of patients requiring ventilation. cache = ./cache/cord-278364-58d8kfdf.txt txt = ./txt/cord-278364-58d8kfdf.txt === reduce.pl bib === id = cord-277739-eb4z3u66 author = Hu, Ke title = Efficacy and Safety of Lianhuaqingwen Capsules, a repurposed Chinese Herb, in Patients with Coronavirus disease 2019: A multicenter, prospective, randomized controlled trial date = 2020-05-16 pages = extension = .txt mime = text/plain words = 3665 sentences = 195 flesch = 48 summary = title: Efficacy and Safety of Lianhuaqingwen Capsules, a repurposed Chinese Herb, in Patients with Coronavirus disease 2019: A multicenter, prospective, randomized controlled trial In the latest publication, Lianhuaqingwen (LH) capsule (Shijiazhuang Yiling Pharmaceutical Co. Ltd., Shijiazhuang, China) was a manufactured product of the traditional Chinese medicine formula marketed in China that could significantly inhibit SARS-CoV-2 replication, alter the viral morphology and confer anti-inflammatory activity in vitro . On the basis of usual treatment, we sought to explore the safety and efficacy of LH capsules in patients with Covid-19 by conducting a multicenter randomized controlled trial in mainland China. Eligibility criteria consisted of the following: 1) Laboratory-confirmed cases with according to the Protocol for Diagnosis and Treatment of Novel Coronarvirus Pneumonia (4 th edition) which was issued by the National Health Commission (General Office Of The National Health And Health Commission, 2020) (Panel 1); 2) Being symptomatic (either having fever, coughing, or fatigue) plus radiologic abnormalities consistent with pneumonia; 3) Patients aged 18 years or greater of either sex. cache = ./cache/cord-277739-eb4z3u66.txt txt = ./txt/cord-277739-eb4z3u66.txt === reduce.pl bib === id = cord-278547-y0hvq0qf author = Testori, Alberto title = Extraordinary emergency measures set up by a Breast Unit to prevent COVID‐19: Report of our experience date = 2020-06-25 pages = extension = .txt mime = text/plain words = 686 sentences = 47 flesch = 52 summary = These measures are also justified by data, suggesting patients with cancer are more susceptible to infection and respiratory complications related to COVID-19 compared to those without cancer, due to immunosuppressive state caused by malignancy and chemotherapy. If reconstruction was needed, patient was admitted on the same day of surgery in a dedicated ward and discharged the day after. In case of patient with COVID-19 and no possibility to postpone surgery, a dedicated surgical theater and ward was available. A recent paper showed a slight prevalence of male patient with diagnosis of COVID-19 and a higher fatality rate (2.8%) when compared to female (1.7%). Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) -China cache = ./cache/cord-278547-y0hvq0qf.txt txt = ./txt/cord-278547-y0hvq0qf.txt === reduce.pl bib === id = cord-277992-49mantab author = Harikrishnan, S. title = Cardiological society of India position statement on COVID-19 and heart failure date = 2020-05-13 pages = extension = .txt mime = text/plain words = 2472 sentences = 165 flesch = 48 summary = The following were reported in CMR in one of the patients with myopericarditis who had ventricular systolic dysfunction : increased wall thickness with diffuse biventricular hypokinesis, especially in the apical segments, marked biventricular myocardial interstitial edema, and diffuse late gadolinium enhancement involving the entire biventricular wall 18 Cardiological Society of India recommends fibrinolytics and pharmacological therapy as treatment of choice in stable STEMI. COVID-19 patients who are diagnosed as having asymptomatic left ventricular systolic dysfunction or clinically overt heart failure should receive standard guideline directed therapy.Careful management of fluid balance, careful monitoring of electrolytes and renal function is very important.Another cardiovascular co-morbidity which can co-exist is venous thromboembolism and adequate prophylactic measures need to be undertaken 13 . Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19) EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF HEART TRANSPLANT RECIPIENTS DURING THE 2019 CORONAVIRUS OUTBREAK IN WUHAN, CHINA: A DESCRIPTIVE SURVEY REPORT cache = ./cache/cord-277992-49mantab.txt txt = ./txt/cord-277992-49mantab.txt === reduce.pl bib === id = cord-277643-xh8z9v0m author = Khatiwada, Asmita Priyadarshini title = Paradigm shift of drug information centers during the COVID-19 pandemic date = 2020-07-20 pages = extension = .txt mime = text/plain words = 3930 sentences = 184 flesch = 38 summary = Pharmacists played a crucial role in direct patient care, medication information, and proper drug distribution with proactive communication among themselves and with other HCPs during the severe acute respiratory syndrome (SARS) pandemic. However, new roles including immunization, contraception, public awareness, identifying infected patients and redirecting them to hospitals and isolation centers, logistics, supplies and clinical management, and being an information hub for patients and HCPs regarding the disease, transmission, preventive measures, management approaches, and investigational medications were identified [14, 15] . Even though the various services provided by the pharmacists during different pandemics were not directly through DICs, pharmacists were actively involved in the dissemination of information on the disease and investigational World Health Organization (WHO)-approved/non-approved medications to the patients, HCPs and the public. Detailed information on COVID-19 and its effects in patients with various health conditions, such as cardiovascular disease (CVD), diabetes mellitus, neurological issues, and respiratory illnesses, can be disseminated to HCPs and patients/ public via DICs, thereby promoting the role of pharmacists in patient management. cache = ./cache/cord-277643-xh8z9v0m.txt txt = ./txt/cord-277643-xh8z9v0m.txt === reduce.pl bib === id = cord-278937-lkuuftno author = Beydon, N. title = Lung function testing during a pandemic: an international perspective date = 2020-10-11 pages = extension = .txt mime = text/plain words = 1872 sentences = 105 flesch = 47 summary = This review aims to summarize different practices of PFT laboratory management in different countries, including patient appointments, personal protective equipment, testing room requirements and telemedicine during and immediately following the COVID pandemic. Considering that there is a possibility of disease transmission to the patients and staff from asymptomatic carriers, precautions for pulmonary function testing (PFT) laboratories have been controversial (5) . These include postponing testing in non-urgent cases, personal protective equipment (PPE) for the respiratory technicians and PFT lab room characteristics such as negative pressure and adequate ventilation, HEPA filters, extensive hygiene measures and social distancing (6) (7) (8) (9) . At some centers, a negative COVID test is required within 72 hours before performing PFTs. Patients and visitors are expected to have a face mask/covering to enter the hospital. Testing personnel: Respiratory therapists or nurses performing all types of pulmonary function testing are screened daily for COVID symptoms by questionnaires and by temperature measurement in many centers. cache = ./cache/cord-278937-lkuuftno.txt txt = ./txt/cord-278937-lkuuftno.txt === reduce.pl bib === id = cord-278332-fbksw3om author = Schlick, Cary Jo R. title = Adequate Lymphadenectomy as a Quality Measure in Esophageal Cancer: Is there an Association with Treatment Approach? date = 2020-06-09 pages = extension = .txt mime = text/plain words = 3945 sentences = 216 flesch = 40 summary = As such, analyses of the impact of quality measure adherence on overall survival in esophageal cancer have relied on the NCCN definition of at least 15 lymph nodes for adequate lymphadenectomy, regardless of the use of neoadjuvant therapy. Thus, the objectives of this study were to (1) explore trends in adequate lymphadenectomy rates over time; (2) evaluate unadjusted lymphadenectomy yield in esophageal cancer based on treatment characteristics; and (3) identify independent factors associated with adequate lymphadenectomy. Considering this finding in light of the fact that many patients do not achieve adequate lymphadenectomy, we argue that the oncologic community should accept a generalized lymphadenectomy threshold regardless of the therapeutic approach, and instead focus on modifiable With regard to surgical approach, we found an increased number of examined lymph nodes with laparoscopic and robotic surgery in comparison with the open approach. However, a focus on surgical approach and esophagectomy volume, which are modifiable factors associated with adequate lymphadenectomy, may promote continuous quality improvement in esophageal cancer care. cache = ./cache/cord-278332-fbksw3om.txt txt = ./txt/cord-278332-fbksw3om.txt === reduce.pl bib === id = cord-278943-f80ucqqp author = Calvillo-Argüelles, Oscar title = Modified Routine Cardiac Imaging Surveillance of Adult Cancer Patients and Survivors during the COVID-19 Pandemic date = 2020-04-16 pages = extension = .txt mime = text/plain words = 1648 sentences = 97 flesch = 39 summary = Many routine tests have relatively low yield for detecting abnormal findings or modifying clinical care in asymptomatic patients.(3) Thus, it may be possible to adopt temporary measures during this pandemic which strike a balance between the early detection and prevention of cancer therapy related cardiac dysfunction (CTRCD) and risk of COVID-19 transmission. Thus, with anthracycline initiation, regardless of dose, it may be reasonable to prioritize baseline cardiac imaging for patients with: 1) established or suspected CVD based on past medical history (e.g. myocardial infarction, cardiomyopathy, arrhythmia, moderate or greater valvular disease); 2) signs or symptoms of cardiac dysfunction; 3) ≥2 risk factors for CTRCD, including age ≥ 60 years, hypertension, diabetes, dyslipidemia, smoking, or obesity. The optimal surveillance regimen during anthracycline chemotherapy remains incompletely In patients who develop CTRCD and require cardiac treatments and/or withholding of cancer therapy, repeat imaging should continue as per institutional standard of care.(10) cache = ./cache/cord-278943-f80ucqqp.txt txt = ./txt/cord-278943-f80ucqqp.txt === reduce.pl bib === id = cord-278672-pxzsntfg author = Milenkovic, Aleksandar title = Extensions and Adaptations of Existing Medical Information System in Order to Reduce Social Contacts During COVID-19 Pandemic date = 2020-06-16 pages = extension = .txt mime = text/plain words = 4609 sentences = 237 flesch = 45 summary = During outbreaks, especially those with a pandemic character, the following key activities [1] which are updated with COVID-19 strategy [2] have been identified whose strict implementation has an impact on the reduction of number of infected people and suppression of the spread of epidemic: 6 . This paper presents the adaptation and extension of existing medical information system (MIS) as an efficient response to the rapid COVID-19 epidemic spread, mostly through influencing the reduction of social contacts and earliest possible identification of potentially infected persons. According to the research findings the integration of patient self-triage tools into electronic health record (EHR) systems has a great potential in improving the triage efficiency and preventing unnecessary visits during the COVID-19 pandemic. The developed subsystem for the use of existing data from MIS MEDIS.NET in the education of students at the Faculty of Medicine and newly employed workers, as well as for medical research [47] , enables tracking and studying the COVID-19 disease at this stage. cache = ./cache/cord-278672-pxzsntfg.txt txt = ./txt/cord-278672-pxzsntfg.txt === reduce.pl bib === id = cord-278106-ev1nx60h author = Cancarevic, Ivan title = Coronavirus Disease 2019 (COVID-19) in Cancer Patients date = 2020-04-26 pages = extension = .txt mime = text/plain words = 2479 sentences = 130 flesch = 50 summary = The Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the most talked-about clinical entity in early 2020. Management presents its own set of challenges, including but not limited to, deciding whether postponing cancer treatment until the infection resolves is going to benefit the patient and how to organize all aspects of patient care when social contact is as limited as it is for patients newly diagnosed with COVID-19. found that the prevalence of cancer among patients infected with SARS-CoV-2 (COVID-19) was higher than in the general population [12] . We would strongly encourage clinicians to keep reporting any cases of cancer patients infected with SARS-CoV-2, their management, and the outcome in order to further our understanding of this complex issue. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges The treatment and outcome of a lung cancer patient infected with SARS-CoV-2 cache = ./cache/cord-278106-ev1nx60h.txt txt = ./txt/cord-278106-ev1nx60h.txt === reduce.pl bib === id = cord-278682-s4gfbsqy author = Chan, W-M title = Precautions in ophthalmic practice in a hospital with a major acute SARS outbreak: an experience from Hong Kong date = 2005-04-29 pages = extension = .txt mime = text/plain words = 4131 sentences = 218 flesch = 47 summary = The ultimate infectivity of the tears secretion and ocular discharge from SARS patients may bring impacts on not only the daily ophthalmic practice but also the universal infection control measures practiced by general public and health-care workers. Discard gloves, wash or alcohol-rub the hands and then put on new gloves in-between case Wear glove in high-risk procedure General categories: for all patients attending the ophthalmic outpatients in which the SARS status is not certain. In a case-control study among 254 Hong Kong health-care workers with documented exposure to SARS patients, none of the 69 staff reporting use of four infection control measures, namely mask, gloves, gowns, and hand washing, was infected. Hospital Authority guideline on infection control of Severe Acute Respiratory Syndrome (SARS) cache = ./cache/cord-278682-s4gfbsqy.txt txt = ./txt/cord-278682-s4gfbsqy.txt === reduce.pl bib === id = cord-278984-0zof6s4d author = El-Tallawy, Salah N. title = Pain Management During the COVID-19 Pandemic date = 2020-08-25 pages = extension = .txt mime = text/plain words = 6475 sentences = 337 flesch = 46 summary = Understanding both the general problems facing chronic pain patients as well as specific problems in the COVID-19 era including deconditioning, increased mental health concerns, financial burdens, and potential for medication-induced immune-suppression is vital in the appropriate management of patients. Understanding both the general problems facing chronic pain patients as well as specific problems in the COVID-19 era including deconditioning, increased mental health concerns, financial burdens, and potential for medication-induced immune-suppression is vital in the appropriate management of patients. Recent recommendations for the safe use of non-opioid analgesics, opioid analgesics, and interventional pain management procedures are vital to know and understand specifically during the pandemic era. Immunosuppression as a result of medication, whether chronic opioid therapy or the use of oral or injectable steroids (e.g., in interventional pain procedures), is especially concerning during a time of global pandemic. Telemedicine has become an effective way of providing necessary medical services to patients with chronic pain during the COVID-19 epidemic. cache = ./cache/cord-278984-0zof6s4d.txt txt = ./txt/cord-278984-0zof6s4d.txt === reduce.pl bib === id = cord-278319-44bvju3g author = Gonzales, Ralph title = Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background date = 2001-06-30 pages = extension = .txt mime = text/plain words = 4804 sentences = 258 flesch = 39 summary = Four prospective studies (1984 to 1990) examined the accuracy of patient history and physical examination for diagnosing radiographic pneumonia in adults with acute respiratory illness in outpatient and emergency department settings, and a clinical decision tool to determine the need for radiography was developed. [42] [43] [44] [45] [46] [47] [48] [49] [50] By the mid-1990s, published reviews of randomized, placebo-controlled trials 51,52 had concluded that routine antibiotic treatment of acute bronchitis does not have a consistent impact on duration or severity of illness or on potential complications, such as development of pneumonia. In epidemiologic studies, respiratory viruses, particularly influenza, appear to cause the large majority of cases of uncomplicated acute bronchitis according to culture, antibody (48) productive cough of any times daily for 10 days group (n = 24) vs. Randomized, controlled trials have demonstrated a consistent benefit of therapy with albuterol versus placebo for uncomplicated acute bronchitis in reducing the duration and severity of cough (in one study, the "placebo" was erythromycin). cache = ./cache/cord-278319-44bvju3g.txt txt = ./txt/cord-278319-44bvju3g.txt === reduce.pl bib === id = cord-278993-w5aa0elj author = Tonetti, Tommaso title = Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy date = 2020-10-12 pages = extension = .txt mime = text/plain words = 3922 sentences = 171 flesch = 44 summary = We retrospectively studied consecutive critically ill patients with confirmed Covid-19 who were referred to the hospitals of the Lombardy, Veneto and Emilia-Romagna regions during the first 2 weeks of the Italian outbreak (February 24March 8, 2020) . The present study describes how the Italian health-care system of three northern Italian regions responded to the increasing need for clinical resources for critically ill patients during the first 14 days of the Covid-19 outbreak through the 28.7% increase in ICU beds and the increasing use of non-invasive respiratory support outside the ICU. Our data show that, compared to patients admitted to the ICU, patients receiving respiratory support outside the ICU were significantly older, had more comorbidities and had a higher PaO 2 /FiO 2 ratio and a lower PaCO 2 . cache = ./cache/cord-278993-w5aa0elj.txt txt = ./txt/cord-278993-w5aa0elj.txt === reduce.pl bib === id = cord-278592-67y4f9av author = Kurup, Asok title = Control of a hospital-wide vancomycin-resistant Enterococci outbreak date = 2008-03-24 pages = extension = .txt mime = text/plain words = 3037 sentences = 174 flesch = 49 summary = To eradicate a hospital-wide outbreak, a coordinated strategy between March and June 2005 comprised (1) formation of a VRE task force, (2) hospital-wide screening, (3) isolation of carriers, (4) physical segregation of contacts, (5) surveillance of high-risk groups, (6) increased cleaning, (7) electronic tagging of VRE status, and (8) education and audits. 1 In 2004, a localized VRE outbreak in a hematology ward of Singapore General Hospital (SGH) involving 6 inpatients was blamed on overseas importation of the index case with breaches in infection control measures, resulting in subsequent dissemination in that ward. Patients with high-risk acquisition for VRE-like end-stage renal failure (ESRF) on dialysis, those with hematologic or oncologic malignancies, those transferred from other local or overseas hospitals, or those with hospital admissions after January 1, 2005 were defined as ''unknowns.'' Records of ''contacts'' and ''unknowns'' were electronically tagged to facilitate VRE screening by stool or rectal swab on 2 separate occasions at least 24 hours apart. cache = ./cache/cord-278592-67y4f9av.txt txt = ./txt/cord-278592-67y4f9av.txt === reduce.pl bib === id = cord-278536-b4eyegx5 author = Piazza, Gregory title = Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19 date = 2020-11-03 pages = extension = .txt mime = text/plain words = 1467 sentences = 93 flesch = 34 summary = OBJECTIVES: To assess the frequency of arterial and venous thromboembolic disease, risk factors, prevention and management patterns, and outcomes in patients with COVID-19, the authors designed a multicenter, observational cohort study. CONCLUSIONS: Major arterial or venous thromboembolism, major adverse cardiovascular events, and symptomatic venous thromboembolism occurred with high frequency in patients with COVID-19, especially in the intensive care setting, despite a high utilization rate of thromboprophylaxis. Whereas the morbidity and mortality associated with COVID-19 are usually attributed to acute respiratory distress syndrome (ARDS) and end-organ failure, cardiovascular complications, including myocardial infarction (MI), ischemic stroke, and pulmonary embolism (PE), also cause disability and death in these patients (1) (2) (3) . Among those admitted to the non-ICU setting (n ¼ 229), the frequency of major arterial or venous thromboembolism, major adverse cardiovascular events, and symptomatic VTE was also elevated but lower than for those with critical illness. cache = ./cache/cord-278536-b4eyegx5.txt txt = ./txt/cord-278536-b4eyegx5.txt === reduce.pl bib === id = cord-279052-8hxdfdls author = Boet, S. title = Protocol for a multicentre randomized controlled trial of normobaric versus hyperbaric oxygen therapy for hypoxemic COVID-19 patients date = 2020-07-16 pages = extension = .txt mime = text/plain words = 4123 sentences = 247 flesch = 46 summary = Secondary outcomes will include: (a) clinical outcomes (length of hospital stay, days with oxygen supplementation, oxygen flow values to obtain a saturation by pulse oximetry [≥]90%, intensive care admission and length of stay, days on invasive mechanical ventilation or high flow oxygen, sleep quality, fatigue, major thrombotic events, the 7-level COVID ordinal outcomes scale on Day 28; mortality, safety); (b) biological outcomes (plasma inflammatory markers); and (c) health system outcomes (cost of care and cost-effectiveness). Secondary objectives: To evaluate the effect of HBOT on: (a) other clinical outcomes (i.e., length of hospital stay; days with oxygen supplementation; daily oxygen flow values required to obtain saturation values ≥90%; ICU admission; ICU length of stay; days on invasive mechanical ventilation or high flow oxygenation; major arterial and venous thrombotic events, such as stroke, pulmonary embolism, deep vein thrombosis; sleep quality; fatigue; the 7-level COVID ordinal outcomes scale assessed on Day 28, mortality, and safety; (b) biologic inflammatory markers, including markers of immune activation response and inflammation; and (c) cost of care for COVID-19 patients and cost-effectiveness of HBOT. cache = ./cache/cord-279052-8hxdfdls.txt txt = ./txt/cord-279052-8hxdfdls.txt === reduce.pl bib === id = cord-279134-s6c7m94h author = Chen, Haiyang title = When cancer encounters COVID-19 in China: what have we suffered, experienced and learned date = 2020-05-16 pages = extension = .txt mime = text/plain words = 4361 sentences = 206 flesch = 45 summary = Therefore, it is of significance to summarize the relevant experience of China in the prevention and control of COVID-19 infection and treatment of patients with cancer during the epidemic. The delay of surgery because of COVID-19 epidemic may significantly affect the prognosis of patients with early stage lung cancer. It's reported that a patient with NSCLC was treated with Kaletra (lopinavir/ritonavir) and osimertinib at the same time after the diagnosis of mild COVID-19 infection; 2 weeks after Kaletra treatment, pneumonia was cured and the tumor remained stable (23) . In the early stage of the epidemic, cross-infection in hospital is one of the most risk for patients and medical workers, so it is very important to screen COVID-19 patients as soon as admission of patients for cancer hospitals. cache = ./cache/cord-279134-s6c7m94h.txt txt = ./txt/cord-279134-s6c7m94h.txt === reduce.pl bib === id = cord-279158-dsnniuo6 author = Luo, Y. title = Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study date = 2020-05-22 pages = extension = .txt mime = text/plain words = 3903 sentences = 200 flesch = 47 summary = title: Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study Through a systematic review, meta-analysis and retrospective cohort study, we found that the low blood sodium population may significantly increase the risk and severity of SARS-CoV-2 infection. In this study, we aimed to find a key risk factor for SARS-CoV-2 epidemic by investigating the relationship between the blood sodium concentration and the severity of patients with COVID-19 through a systematic reviews, meta-analysis and retrospective cohort study. For the systematic review and meta-analysis, median or mean values of serum sodium, chloride and potassium concentrations from each report were considered as an independent variable for statistical analysis, and an unpaired t-test was used to compare the differences between the groups related to the severity of disease. In this study, we found that the patients infected by SARS-CoV-2 on admission have presented the low blood sodium levels (hyponatremia) that were related to the disease severity. cache = ./cache/cord-279158-dsnniuo6.txt txt = ./txt/cord-279158-dsnniuo6.txt === reduce.pl bib === id = cord-279111-jaa45kyc author = Ieven, M. title = Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries date = 2018-02-12 pages = extension = .txt mime = text/plain words = 4079 sentences = 208 flesch = 46 summary = OBJECTIVES: To describe the role of bacteria (including bacterial resistance), viruses (including those recently described) and mixed bacterial–viral infections in adults presenting to primary care with lower respiratory tract infection (LRTI). Methods: In all, 3104 adults with LRTI were enrolled, of whom 141 (4.5%) had community-acquired pneumonia (CAP), and 2985 matched controls in a prospective study in 16 primary care networks in Europe, and followed patients up at 28e35 days. Methods: In all, 3104 adults with LRTI were enrolled, of whom 141 (4.5%) had community-acquired pneumonia (CAP), and 2985 matched controls in a prospective study in 16 primary care networks in Europe, and followed patients up at 28e35 days. Our primary objective was to describe the viral and bacterial aetiology in adult patients presenting to primary care with LRTI and in those with community-acquired pneumonia (CAP). cache = ./cache/cord-279111-jaa45kyc.txt txt = ./txt/cord-279111-jaa45kyc.txt === reduce.pl bib === id = cord-279435-ffgd2ets author = ALBalawi, Hani B title = COVID-19: Precautionary Guidelines for Ophthalmologists date = 2020-06-25 pages = extension = .txt mime = text/plain words = 3183 sentences = 148 flesch = 49 summary = Healthcare providers, particularly ophthalmologists, are at high risk of a COVID-19 infection through unprotected contact with eye secretions during routine ophthalmic examinations that involve the use of direct ophthalmoscopy and slit-lamp examinations, which are usually performed in a setting that allows for close doctor-patient contact. In fact, ophthalmologists are at high risk of contracting the COVID-19 virus through unprotected eye contact with secretions during routine ophthalmic examinations with direct ophthalmoscopy and slit-lamp examinations, which are usually performed in a setting that has close doctor-patient contact. A three-stage control measure to reduce the transmission of the virus in the ophthalmology department in Hong Kong was based on text messaging to reschedule refill visits [6] ; a triage to identify patients with fever, conjunctivitis, and respiratory symptoms; asking those who recently traveled to areas infected with the virus to postpone their ophthalmology visits for 14 days; and the avoidance of micro-aerosol generating procedures, nasal endoscopy, and operations under general anesthesia. cache = ./cache/cord-279435-ffgd2ets.txt txt = ./txt/cord-279435-ffgd2ets.txt === reduce.pl bib === id = cord-278838-qraq5aho author = Mirouse, Adrien title = Severe varicella-zoster virus pneumonia: a multicenter cohort study date = 2017-06-07 pages = extension = .txt mime = text/plain words = 4702 sentences = 261 flesch = 44 summary = Half the patients received mechanical ventilation within 1 (1–2) day following ICU admission (the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO(2)/FiO(2)) = 150 (80–284), 80% with acute respiratory distress syndrome (ARDS)). Sequential Organ Failure Assessment (SOFA) score on day 1 (odds ratio (OR) 1.90 (1.33–2.70); p < 0.001), oxygen flow at ICU admission (OR 1.25 (1.08–1.45); p = 0.004), and early bacterial co-infection (OR 14.94 (2.00–111.8); p = 0.009) were independently associated with the need for mechanical ventilation. Results are presented for the imputed data Candidate predictors were: age, any comorbidity, underlying immunosuppression, SOFA score at day 1, oxygen flow at ICU admission, alveolar consolidation on chest X-ray, antibiotics at ICU admission, and early bacterial co-infection CI confidence interval, ICU intensive care unit, OR odds ratio, SOFA Sequential Organ Failure Assessment In our study, the overall mortality was 24% and reached 43% in patients who received invasive mechanical ventilation. cache = ./cache/cord-278838-qraq5aho.txt txt = ./txt/cord-278838-qraq5aho.txt === reduce.pl bib === id = cord-278256-dmrtsxik author = Qiu, Haiyan title = Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study date = 2020-03-25 pages = extension = .txt mime = text/plain words = 3458 sentences = 199 flesch = 50 summary = title: Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study INTERPRETATION: Although all paediatric patients in our cohort had mild or moderate type of COVID-19, the large proportion of asymptomatic children indicates the difficulty in identifying paediatric patients who do not have clear epidemiological information, leading to a dangerous situation in community-acquired infections. All children with COVID-19 had been infected either by close contact with adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or by exposure to the epidemic area. By contrast with findings in adults, children with COVID-19 had milder clinical manifestations; nearly half of paediatric patients were asymptomatic (ie, no fever and no cough). When compared with children with SARS, paediatric patients with COVID-19 had much milder disease in terms of the prevalence of fever, cough, pneumonia, and severe case type. cache = ./cache/cord-278256-dmrtsxik.txt txt = ./txt/cord-278256-dmrtsxik.txt === reduce.pl bib === id = cord-279299-5djtiomq author = CAO, HUI-FANG title = A confirmed severe case of human infection with avian-origin influenza H7N9: A case report date = 2014-12-30 pages = extension = .txt mime = text/plain words = 2563 sentences = 127 flesch = 45 summary = The day after admission to the Jingnan District Centre Hospital of Shanghai (Shanghai, China), the patient was diagnosed with severe H7N9 avian influenza infection by nasopharyngeal swab and blood sampling detection. In the present study, the patient exhibited a rapid deterioration; however, a diagnosis of H7N9 avian influenza was only confirmed after five days of continuous fever. Considering the initial diagnosis of severe pneumonia complicated with type I respiratory failure, the patient was administered oxygen therapy and methylprednisolone to reduce the systemic inflammatory response, and biapenem (0.6 g twice daily, i.v) and azithromycin (0.5 g/day, i.v) were applied as anti-infective agents. Combining the epidemiological history and the rapid progression in the pulmonary lesions of the patient (Fig. 3) , a diagnosis of human infection with H7N9 avian influenza was considered. cache = ./cache/cord-279299-5djtiomq.txt txt = ./txt/cord-279299-5djtiomq.txt === reduce.pl bib === id = cord-279357-83hisxro author = de Leon, Jose title = Clozapine is strongly associated with the risk of pneumonia and inflammation date = 2020-04-16 pages = extension = .txt mime = text/plain words = 4953 sentences = 254 flesch = 45 summary = Clinicians need to remember that (1) systemic inflammations can increase clozapine level; (2) clozapine, by itself, can cause inflammation, particularly during titration that is too rapid for that patient; (3) clozapine may increase the risk of infection; and (4) more specifically, clozapine may be particularly strongly associated with the risk of pneumonia. 13 Therefore, based on the US 8 14 and Chinese experiences [11] [12] [13] as well as on the literature, 10 we proposed that clinicians need to be very alert regarding clozapine patients' risk of clozapine intoxications during any kind of systemic inflammation associated with fever and/or CRP elevations. Some case reports and observational studies previously reviewed in another article 11 suggest that infections can increase the serum concentrations of antipsychotics metabolised by CYP3A4. cache = ./cache/cord-279357-83hisxro.txt txt = ./txt/cord-279357-83hisxro.txt === reduce.pl bib === id = cord-279456-oouylyx9 author = Henchi, Sonia title = First COVID-19 sub-intensive respiratory unit in Europe: the Italian experience date = 2020-06-23 pages = extension = .txt mime = text/plain words = 1501 sentences = 101 flesch = 47 summary = European SARS-CoV-2 pandemic epicenter was detected in Northern Italy, in a little Italian town of Lodi province, the Lodi Hospital was therefore rapidly saturated, and in particularly the departments of respiratory diseases and Intensive Care Unit had been largely involved. In this paper, we describe how the first Sub-intensive Respiratory Unit in Europe completely dedicated to COVID-19 patients was organized and managed in our hospital. SARS-CoV-2 related disease, COVID-19, presents a wide spectrum of clinical manifestations, from flu-like symptoms to severe pneumonia and acute respiratory distress syndrome (ARDS) [2] . In UTISIR were admitted patients testing positive to SARS-CoV-2 throat swab with phenotype 3,4,5, ICU patients weaned from intubation, with tracheostomy and transferred from other low-intensity care departments of the hospital, when appropriated. 4. Respiratory failure with suspected ARDS or severe pneumonia: CPAP or intubation required → hospitalization in COVID-19 ICU or COVID19 UTISIR. cache = ./cache/cord-279456-oouylyx9.txt txt = ./txt/cord-279456-oouylyx9.txt === reduce.pl bib === id = cord-279056-mmcoqtb5 author = Seirafianpour, Farnoosh title = Cutaneous manifestations and considerations in COVID‐19 pandemic: A systematic review date = 2020-07-08 pages = extension = .txt mime = text/plain words = 4651 sentences = 262 flesch = 46 summary = BACKGROUND: COVID‐19 had a great impact on medical approaches among dermatologist OBJECTIVE: This systematic review focuses on all skin problems related to COVID‐19, including primary and secondary COVID‐related cutaneous presentations and the experts recommendations about dermatological managements especially immunomodulators usage issues METHOD: Search was performed on PubMed, Scopus, Embase and ScienceDirect. Totally 5 article were about skin drug reactions of COVID-19 treatments; two of them were original studies as case reports that were summarized in Table 7 (in the supplement file). In overall, non-infected non-at risk patients with immune-medicated dermatologic disorders under usage of immunosuppressive immunomodulator drugs like biologic agents are not needed to be alter regimen or discontine the therapies during pandemic, even these drugs may control the deteriorating cytokine storms also prevented disease flare-ups which both were associated with poorer outcomes and more complications in COVID-19 course, although strict adherence to quarantine and personal-social preventive hygiene performances are highly recommended especially in these groups of patients. cache = ./cache/cord-279056-mmcoqtb5.txt txt = ./txt/cord-279056-mmcoqtb5.txt === reduce.pl bib === id = cord-279557-hk77e3pp author = Drosten, Christian title = Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection date = 2013-06-17 pages = extension = .txt mime = text/plain words = 4214 sentences = 243 flesch = 55 summary = BACKGROUND: The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, Tunisia, Morocco, France, Italy, Germany, and the UK. [4] [5] [6] Here, we provide a full description of a fatal case of MERS-CoV infection imported to Munich, Germany, from Abu Dhabi, including a chronological profi le of virus concentrations in diverse body compartments. We subjected all available MERS-CoV genome sequences to phylogenetic analysis, including a correlation and regression analysis of known dates of virus isolation versus tree branch lengths (fi gure 3). Without quantitative laboratory data from well documented cases of MERS-CoV infection, most considerations had been made on the basis of an assumed analogy to severe acute respiratory syndrome (SARS). The recorded viral load profi le, with highest RNA concentrations in bronchoalveolar lavage and tracheobronchial aspirates, confi rms suggestions made in another report about the preferential use of lower-respiratory-tract samples for virus diagnostic tests. cache = ./cache/cord-279557-hk77e3pp.txt txt = ./txt/cord-279557-hk77e3pp.txt === reduce.pl bib === id = cord-279480-nqp1pc9v author = Ring, Laurence E. title = What Obstetricians should know about Obstetric Anesthesia during the COVID-19 pandemic date = 2020-08-26 pages = extension = .txt mime = text/plain words = 2783 sentences = 144 flesch = 39 summary = Suggested modifications include an added emphasis on avoiding general anesthesia, a strong encouragement to infected individuals to opt for early neuraxial analgesia, and the prevention of emergent cesarean delivery, whenever possible. Compared to standard care in noninfected patients, the anesthesiologist may be more likely to replace a questionably functional epidural catheter in COVID-19 infected patients, in hopes to avoid urgent situations that may increase the odds for patient adverse outcomes (e.g. accidental dural puncture during a replacement of epidural catheter, or general anesthesia if urgent cesarean delivery) or avoidable exposures for healthcare providers (rushed replacement of neuraxial analgesia/anesthesia or general anesthesia in the operating room). If there does need to be a cesarean delivery on a patient who does not have an epidural catheter and is COVID-19 positive, the anesthesia team will need to weigh the risk of general anesthesia, including the risk staff exposure, to the possible risk of delay due to placement of a neuraxial block (typically a single shot spinal). cache = ./cache/cord-279480-nqp1pc9v.txt txt = ./txt/cord-279480-nqp1pc9v.txt === reduce.pl bib === id = cord-279238-d49jvws2 author = Folesani, Gianluca title = Cardiac surgery model during COVID-19 pandemic: now it’s time to ramp up date = 2020-07-09 pages = extension = .txt mime = text/plain words = 504 sentences = 39 flesch = 62 summary = The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) spread rapidly from China 1 worldwide and on March 11 th 2020 the WHO declared the so-called COVID-19 a pandemic. All kind of Surgery Units stopped to treat elective cases focusing on urgent/emergent patients to minimize Intensive Care Unit beds utilization. Patients with underlying cardiovascular diseases have an increased risk of developing into the severe form of COVID-19 4 , while health-care workers are exposed to the risk of contagion or to become vectors of transmission. Emilia-Romagna is the third Region for the number of infections, after Lombardy and Piedmont, and the S.Orsola Hospital, University of Bologna, became the main regional Hub center for COVID-19. Actually, in our center, each patient undergoes nasopharingeal swab one day before the hospitalization. If there's an emergent case, a nasopharingeal swab is performed and the patient is considered suspect until the result of the test. cache = ./cache/cord-279238-d49jvws2.txt txt = ./txt/cord-279238-d49jvws2.txt === reduce.pl bib === id = cord-279197-cesemos0 author = Block, Keith I. title = Integrative Cancer Therapies: Learning From COVID-19 date = 2020-06-21 pages = extension = .txt mime = text/plain words = 4112 sentences = 228 flesch = 40 summary = Not only has COVID-19 suddenly converted us to a reliance on telehealth that is likely to persist in the future, it has also highlighted the use of some integrative therapies commonly used by cancer patients that have previously been thought to be too controversial for conventional clinics, but that might bear further research attention. For instance, 3 meta-analyses of randomized trials of chemotherapy in colorectal cancer patients found that performance status predicted mortality, [12] [13] [14] in addition to treatment side effects. Along with the previously published beneficial effects of parenteral fish oil emulsions in cancer patients, 30 these vitamin C trials raise the question of the potentials of other unconventional intravenous treatments in cancer patients. Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer cache = ./cache/cord-279197-cesemos0.txt txt = ./txt/cord-279197-cesemos0.txt === reduce.pl bib === id = cord-279550-7u2hksxm author = Wang, Kai title = Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection date = 2020-08-03 pages = extension = .txt mime = text/plain words = 2656 sentences = 190 flesch = 56 summary = METHODS: Blood samples (n=173) were collected from 30 COVID-19 patients over a 3-month period after symptom onset and analyzed for SARS-CoV-2-specific NAbs, using the lentiviral pseudotype assay, coincident with the levels of IgG and proinflammatory cytokines. Thus, serological testing, especially to detect NAbs, is essential in determining the onset of the serological immune response, evaluating the potential capacity of the host body for viral clearance, and identifying donors for passive antibody therapy trials. 12, 13 However, the dynamics and roles of SARS-CoV-2-specific NAbs and their correlation with antibody responses have not been explored in COVID-19 patients more than two months after symptom onset. Furthermore, to determine if there was a statistical correlation between NAb levels and virus-specific IgG levels in COVID-19 patients, serum samples were grouped by time (weeks) after symptom onset. In summary, we determined the dynamics of NAb titers within 3 months after symptom onset in 30 SARS-CoV-2-infected patients and found a positive correlation between NAb titers and IgG antibodies. cache = ./cache/cord-279550-7u2hksxm.txt txt = ./txt/cord-279550-7u2hksxm.txt === reduce.pl bib === id = cord-279513-m4jdc8ua author = Onesti, Concetta Elisa title = Oncological care organisation during COVID-19 outbreak date = 2020-08-26 pages = extension = .txt mime = text/plain words = 4145 sentences = 204 flesch = 49 summary = A triage for patients with cancer before hospital or clinic visits was conducted by 90.5% of centres before consultations, 95.2% before day care admissions and in 100% of the cases before overnight hospitalisation by means of phone calls, interactive online platforms, swab test and/or chest CT scan. The topics investigated in the survey included preventive measures taken before and after admission to the hospital, instructions given to patients and professionals, general measures for risk reduction of virus spread, specific measures in the hospitalisation unit, general organisation of the centre, organisation of multidisciplinary meetings and activities of other healthcare professionals, staff management and antibody testing. Patients were subjected to a triage for signs of infection prior to presenting to the oncology units in the majority of the centres, notably in 19/21 institutions (90.5%) before consultations, in 20/21 (95.2%) before day care outpatient infusion room admissions and in 20/20 (100%) before overnight hospitalisation (figure 2). cache = ./cache/cord-279513-m4jdc8ua.txt txt = ./txt/cord-279513-m4jdc8ua.txt === reduce.pl bib === id = cord-279667-ikfduu2k author = Ronnje, Louise title = Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery date = 2020-09-04 pages = extension = .txt mime = text/plain words = 3361 sentences = 207 flesch = 50 summary = title: Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery Severe COVID-19 promptly improved by the termination of the pregnancy or atypical HELLP (Hemolysis, Elevated Liver Enzymes and Low Platelet Count) exacerbated by concomitant COVID-19 infection could not be ruled out. CONCLUSIONS: This case adds to the growing body of evidence which raises concerns about the possible negative maternal outcomes of COVID-19 infection during pregnancy and advocates for pregnant women to be recognized as a vulnerable group during the current pandemic. We report a case of severe COVID-19 during in third trimester pregnancy, which led to an emergency Caesarean section and preterm delivery at 32 + 6 weeks of gestational age. Atypical presentation of HELLP could not be ruled out and the importance of a multidisciplinary team in the treatment and management of severe COVID-19 during pregnancy is critical for positive patient outcome. cache = ./cache/cord-279667-ikfduu2k.txt txt = ./txt/cord-279667-ikfduu2k.txt === reduce.pl bib === id = cord-279570-lgbqpfh5 author = Fragkou, Paraskevi C. title = Clinical characteristics and outcomes of measles outbreak in adults: a multicenter retrospective observational study of 93 hospitalized adults in Greece date = 2020-08-26 pages = extension = .txt mime = text/plain words = 2743 sentences = 166 flesch = 48 summary = In this study we aim to describe the clinical characteristics and complications of measles infection in hospitalized adults during the recent epidemic in Greece. All adult hospitalized patients (≥18 years old) with serologically confirmed and/or clinical features compatible with measles were included. In this study, we describe our experience from the recent outbreak of measles in adult hospitalized patients in Greece [8] . One obese female patient with a Grade II hepatic involvement and pneumonitis that progressed rapidly into acute respiratory distress syndrome (ARDS) requiring mechanical ventilation, died within 6 days of her admission due to high-risk pulmonary embolism (PE) despite being treated with ribavirin. In this study we describe the clinical features and outcomes of mostly healthy and young adult hospitalized patients with measles. In summary, in this study we presented the clinical characteristics of measles infection during the recent epidemic in hospitalized adults in Greece. cache = ./cache/cord-279570-lgbqpfh5.txt txt = ./txt/cord-279570-lgbqpfh5.txt === reduce.pl bib === id = cord-279396-qmixem8i author = Carter, Chris title = COVID-19 Disease: a critical care perspective date = 2020-06-01 pages = extension = .txt mime = text/plain words = 5302 sentences = 288 flesch = 49 summary = In addition to the relatively high numbers of COVID-19 patients developing severe respiratory failure resulting in acute respiratory distress syndrome (ARDS) and requiring intubation and ventilatory support, the current data suggests an average length of stay for COVID patients in intensive care of eight days. The critical care nurse needs to recognise that patients who develop severe COVID-19 can rapidly develop Type 1 Respiratory Failure, ARDS and therefore require ventilatory support. 18 In non COVID-19 patients with increasing respiratory failure the use of High Flow Nasal Oxygen (HFNO) or Non-Invasive Ventilation (NIV) such as Continuous Positive Airway Pressure (CPAP) may be used as a treatment strategy. 40 There is also a suggestion that an increased number of healthcare professionals is needed when providing care, particularly in critical care for procedures requiring two nurses to one patient (2:1) when PPE is worn. cache = ./cache/cord-279396-qmixem8i.txt txt = ./txt/cord-279396-qmixem8i.txt === reduce.pl bib === id = cord-279846-g0ro8pbb author = Terrigno, Vittorio R title = Right Atrial Thrombus in a Patient With COVID-19 date = 2020-07-28 pages = extension = .txt mime = text/plain words = 1056 sentences = 65 flesch = 47 summary = We highlight the successful use of half-dose anticoagulation in the treatment of right atrial thrombus in a patient with COVID-19. To our knowledge, this is a first reported case of right atrial thrombus in a COVID-19 patient who was treated successfully with half-dose anticoagulation. In another three-center retrospective study of 184 COVID-19 ICU patients from the Netherlands, the authors reported 31% incidence of thrombotic complications. Therefore, the true incidence is likely higher.Our case supports the need to think of initiating therapeutic anticoagulation early in the course of critically ill patients with COVID-19. In addition to this, our case also highlights the use of half-dose anticoagulation therapy to treat a right atrial thrombus. To our knowledge, this is the first reported case of right atrial thrombus in a COVID-19 patient that resolved with a half dose of thrombolytic therapy. We highlight the ability to treat a right atrial thrombus in a patient with COVID-19 with half-dose anticoagulation. cache = ./cache/cord-279846-g0ro8pbb.txt txt = ./txt/cord-279846-g0ro8pbb.txt === reduce.pl bib === id = cord-279732-cea0nt8z author = Bentley, Suzanne K. title = Guidance and Patient Instructions for Proning and Repositioning of Awake, Non‐Intubated COVID‐19 Patients date = 2020-06-29 pages = extension = .txt mime = text/plain words = 963 sentences = 62 flesch = 43 summary = Literature and experience from healthcare teams in the midst of the pandemic suggest that any COVID‐19 patients with respiratory compromise severe enough to warrant admission should be considered for proning. Prior studies on proning awake, non-intubated patients with hypoxemic acute respiratory failure, 1,2 as well as evolving study of similar COVID-19 patients, [3] [4] [5] [6] coupled with experience and dramatic anecdotal evidence from the COVID-19 pandemic, suggest the importance of proning all such patients with COVID-19 to improve oxygenation and reduce respiratory effort. Literature and experience from healthcare teams in the midst of the pandemic suggest that any COVID-19 patients with respiratory compromise severe enough to warrant admission should be considered for proning. All rights reserved Care Society Guidance for Prone Positioning of the Conscious COVID-19 Patient 7 includes the following absolute contraindications: acute respiratory distress (requiring higher level intervention e.g. immediate need for intubation), hemodynamic instability, agitation or altered mental status, unstable spine, thoracic injury, or recent abdominal surgery. cache = ./cache/cord-279732-cea0nt8z.txt txt = ./txt/cord-279732-cea0nt8z.txt === reduce.pl bib === id = cord-279790-zzvetjrt author = Zeng, Liujun title = Strategic plan for management in oral and maxillofacial surgery during COVID-19 epidemic date = 2020-04-11 pages = extension = .txt mime = text/plain words = 989 sentences = 54 flesch = 47 summary = However, in China, there are still numerous patients with other diseases, especially trauma and cancer requiring surgical treatment. If the oral cancer patient also suffers from COVID-19 or is an asymptomatic virus carrier, check-up and treatment procedures probably cause the spread of the virus through droplets, posing a significant risk to the medical staff. During the epidemic, chemotherapy or radiotherapy can be used as the alternative to surgical treatment in some oral cancer patients. The surgical personnel during operation are required to wear standard personal protection, including N95 masks, disposable protective clothing, disposable shoe covers, goggles or face screen protection. Oral and maxillofacial surgery generally involves the upper respiratory tract, and the surgical site is often contaminated by saliva, so when the electrosurgical equipment is used, powerful suction should be applied to reduce the diffusion of surgical smoke and aerosols. Moreover, for novel coronavirus-infected patients including asymptomatic virus carriers, the virus can spread through splashing of respiratory secretions when the patients cough. cache = ./cache/cord-279790-zzvetjrt.txt txt = ./txt/cord-279790-zzvetjrt.txt === reduce.pl bib === id = cord-279571-chiadufa author = Cui, Xiaoyang title = Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study date = 2020-07-24 pages = extension = .txt mime = text/plain words = 3928 sentences = 226 flesch = 54 summary = Compared with patients without AKI, patients with AKI had more severe organ dysfunction, as indicated by a higher level of disease severity status, higher sequential organ failure assessment (SOFA) score on admission, an increased prevalence of shock, and a higher level of respiratory support. CONCLUSION: Our findings show that admission SOFA score was an independent risk factor for AKI in COVID-19 patients, and patients with AKI had higher in-hospital mortality. In particular, acute kidney injury (AKI) is a common, serious complication in critically ill patients, which may result in increased mortality, longer hospital stays, and higher medical costs [5] . The aim of this study was to evaluate the incidence, risk factors, and impact on mortality of AKI in critically ill patients with COVID-19. In our study, AKI patients had a significant higher mortality rate after adjusting for admission SOFA score, severity status, respiratory support method, and shock. cache = ./cache/cord-279571-chiadufa.txt txt = ./txt/cord-279571-chiadufa.txt === reduce.pl bib === id = cord-280070-c1bkhgaz author = Azadeh, Natalya title = The Role of Infection in Interstitial Lung Diseases A Review date = 2017-10-31 pages = extension = .txt mime = text/plain words = 6524 sentences = 399 flesch = 40 summary = Prognosis can vary according to the type of ILD, but many exhibit gradual progression with an unpredictable clinical course in individual patients, as seen in idiopathic pulmonary fibrosis and the phenomenon of "acute exacerbation"(AE). Diagnostic evaluations of patients with suspected ILD also need to consider infections, since they can cause various histopathologic patterns commonly associated with ILDs including NSIP, LIP, organizing pneumonia, and eosinophilic pneumonia, among others (Table 1) . Richter et al 19 19 It is currently difficult to determine whether patients with IPF are more susceptible to infection or colonization due to abnormal lung parenchyma, associated traction bronchiectasis, and immunosuppressive medications (which historically have been commonly used for treatment of ILDs), or whether bacteria are involved as triggers of AE or in the pathogenesis of IPF. Histopathologic features and outcome of patients with acute exacerbation of idiopathic pulmonary fibrosis undergoing surgical lung biopsy Acute exacerbation of idiopathic pulmonary fibrosis: role of Chlamydophila pneumoniae infection cache = ./cache/cord-280070-c1bkhgaz.txt txt = ./txt/cord-280070-c1bkhgaz.txt === reduce.pl bib === id = cord-279719-z0wuajpx author = Martin-Fumadó, Carles title = Medico-legal and ethical considerations on resource limitation and clinical decisions during the COVID-19 pandemic date = 2020-07-15 pages = extension = .txt mime = text/plain words = 4957 sentences = 263 flesch = 46 summary = Resource rationing has been necessary in the COVID-19 pandemic, and therefore consensus documents have been published for decision-making based on four fundamental ethical values: maximization of benefits, treating people equally, contributing to creating social value and giving priority to the worst off, from which specific recommendations derive: maximize benefits; prioritize health workers; do not prioritize attendance on a first-COme, first-served basis; be sensitive to scientific evidence; recognize participation in research and apply the same principles to COVID-19 patients as to non-COVID-19 patients. The aspects associated with the principle of justice expressed by Beauchamp and Childress will therefore be of key importance in resolving the ethical and medical-legal problems arising from the fair assignation of resources during the COVID-19 pandemic. cache = ./cache/cord-279719-z0wuajpx.txt txt = ./txt/cord-279719-z0wuajpx.txt === reduce.pl bib === id = cord-279483-gwikyux2 author = Wong, Joshua Guoxian title = Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department date = 2020-11-02 pages = extension = .txt mime = text/plain words = 4297 sentences = 247 flesch = 43 summary = title: Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department We aim to provide an evidence-based clinical decision support tool for antibiotic prescribing using prediction models developed from local data. From 2009 to 2010, adults had the highest rate of inappropriate antibiotic use for acute respiratory tract infections (URTIs, influenza, and viral pneumonia), with 500 antibiotic prescriptions per 1000 ED visits for adults aged 20-64 years and 666 per 1000 visits for those aged > = 65 years [10] . In this study, we aim to develop prediction models based on local clinical and laboratory data to guide antibiotic prescribing for adult patients with uncomplicated URTI with the ultimate goal of deploying them as an evidencebased clinical decision support tool for routine practice. Antibiotic prescribing for patients with upper respiratory tract infections by emergency physicians in a Singapore tertiary hospital cache = ./cache/cord-279483-gwikyux2.txt txt = ./txt/cord-279483-gwikyux2.txt === reduce.pl bib === id = cord-280129-a97rvtzl author = Honore, Patrick M. title = Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation date = 2020-06-16 pages = extension = .txt mime = text/plain words = 553 sentences = 39 flesch = 49 summary = authors: Honore, Patrick M.; Barreto Gutierrez, Leonel; Kugener, Luc; Redant, Sebastien; Attou, Rachid; Gallerani, Andrea; De Bels, David title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation Patrick M. Both patients were treated with classical medical therapy including lactulose, but, despite increasing doses of lactulose for 3 days, ammonia levels remained unchanged. Retrospectively, we hypothesize that the pre-admission diarrhea may have resulted in secondary carnitine deficiency, as described in the literature [3] , leading to hyperammonemia unresponsive to medical therapy [4] . As we did not measure serum carnitine levels and we did not supply the patients with carnitine supplementation, the diagnosis of carnitine deficiency in these cases remains only a hypothesis. Liver injury in critically ill patients with COVID-19: a case series cache = ./cache/cord-280129-a97rvtzl.txt txt = ./txt/cord-280129-a97rvtzl.txt === reduce.pl bib === id = cord-280097-f7ky61ds author = Zarogoulidis, Paul title = Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? date = 2011-01-07 pages = extension = .txt mime = text/plain words = 3167 sentences = 194 flesch = 55 summary = title: Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? BACKGROUND: The World Health Organization alert for the H1N1 influenza pandemic led to the implementation of certain measures regarding admission of patients with flu-like symptoms. The aim of this study was to retrospectively examine the characteristics of all subjects admitted to the Unit of Infectious Diseases with symptoms indicating H1N1 infection, and to identify any differences between H1N1 positive or negative patients. The purpose of this study was to investigate the potential differences on admission between H1N1 positive and negative patients with flu-like symptoms. These elevated values (C-reactive protein and WBC) are known to be associated with bacterial infection and early antibiotic treatment prevents progression of the disease as reported in previous studies [19] [20] [21] . Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? cache = ./cache/cord-280097-f7ky61ds.txt txt = ./txt/cord-280097-f7ky61ds.txt === reduce.pl bib === id = cord-280278-gq1hnnwh author = Chi, Meng title = A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management date = 2020-06-08 pages = extension = .txt mime = text/plain words = 807 sentences = 56 flesch = 50 summary = Health care workers are exposed to high-risk environments when patients infected with COVID-19 require advanced airway management. However, patients cannot wear masks during positive pressure ventilation and endotracheal intubation, exposing health care workers to high-risk environments, even if effective protective measures were taken. The PVC membrane should be sufficiently large (> 100 cm × 100 cm is recommended) to cover the head of the patient and have a hole (sealed when necessary) in the center for the connection between the face mask and the circuit during oxygen inhalation and positive pressure ventilation. Before advanced airway management, the PVC membrane with an assembled face mask under the membrane is placed over the patient's mouth and nose for the induction of intubation (Fig. 1a) . Our appliance reduces the spread of droplets and aerosols from patients, blocking the airborne transmission route of the virus to a large extent and providing a new layer of protection for health care workers during advanced airway management. cache = ./cache/cord-280278-gq1hnnwh.txt txt = ./txt/cord-280278-gq1hnnwh.txt === reduce.pl bib === id = cord-279736-udsbcqfs author = Abdalkader, Mohamad title = Roadmap for Resuming Elective Neuroendovascular Procedures Following the First COVID-19 Surge date = 2020-07-27 pages = extension = .txt mime = text/plain words = 1887 sentences = 74 flesch = 31 summary = As we emerge from the peak of the COVID-19 pandemic's initial surge, we prepare for re-entry of elective neurointerventional procedures to optimize the care of patients and mitigate infectious risk, while concurrently preserving ongoing capacity to care for patients with COVID-19. Anticipated potential limitations in health care resources (personal protective equipment (PPE), ventilators, personnel, hospital space) resulted in triaged delays of non-emergent endovascular procedures and surgeries [1] [2] [3] . We discuss several aspects of care that should be considered during the neuroendovascular resumption of an elective phase including hospital bed capacity, PPE resources, pre-procedure testing and post-procedure care. While the re-introduction of neurointerventional elective procedures can expose an additional specific and related risk of infection and stress, advance preparation and the development of modified pre-procedure protocols, intra-procedural protocols (sharing similarities with acute neurological emergencies) [7] [8] [9] , and post-procedural protocols can help organize the care of the patient, optimize peri-procedural risk to both patient and health care provider, and accommodate for appropriate resource allocation. cache = ./cache/cord-279736-udsbcqfs.txt txt = ./txt/cord-279736-udsbcqfs.txt === reduce.pl bib === id = cord-280005-i9fp5rys author = Wang, Mengmei title = Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -- a Single-Center, Randomized, Controlled Clinical Trial date = 2020-09-21 pages = extension = .txt mime = text/plain words = 3185 sentences = 172 flesch = 49 summary = title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -a Single-Center, Randomized, Controlled Clinical Trial CONCLUSIONS: In COVID-19 patients with prolonged PCR positivity, no benefit in terms of the duration of viral shedding was observed with the combined treatment of leflunomide and IFN α-2a beyond IFN α-2a alone. Based on that background, we conducted a prospective randomized, controlled, open-label trial, to evaluate the efficacy and safety of oral leflunomide to treat hospitalized COVID-19 patients with prolonged post-symptomatic viral shedding. Fifty eligible patients were randomly assigned to a combination treatment group that received leflunomide (50 mg, q12h, three consecutive times, orally; then 20 mg, once a day for 8 days; a total course of 10 days) plus nebulized IFN -2a (3 million IU each time, adding 2 ml of sterilized water, atomization inhalation twice daily for 10 days), or to a control group that received nebulized IFN -2a This was an open-label, prospective randomized, controlled trial, which was conducted at East Campus, Renmin Hospital of Wuhan University. cache = ./cache/cord-280005-i9fp5rys.txt txt = ./txt/cord-280005-i9fp5rys.txt === reduce.pl bib === id = cord-280507-1nf2ycp3 author = Álvarez‐Román, MT title = Clinical trials and Haemophilia during the COVID‐19’ pandemic: Madrid’s Experience date = 2020-05-16 pages = extension = .txt mime = text/plain words = 1090 sentences = 61 flesch = 49 summary = Communication between all members of a research team is key to adapting the development of clinical trials to the context of the epidemiological crisis of coronavirus. Communication between all members of a research team is key to adapting the development of clinical trials to the context of the epidemiological crisis of coronavirus. These shipments of medication coincided with visits made by telephone by the investigator delegated as responsible for the research team, and by the study coordinator and/or the trial nurse. Regarding in-person visits with patients, there were two occasions where patients picked up the medication at the beginning of March at Hospital La Paz. One paediatric patient received prophylaxis by nurses because the training for the administration of the treatment had not yet taken place. All rights reserved There was another in-person visit by an adult patient for the administration of subcutaneous medication by the nurses of the centre, because he was not trained to administer it himself. cache = ./cache/cord-280507-1nf2ycp3.txt txt = ./txt/cord-280507-1nf2ycp3.txt === reduce.pl bib === id = cord-280628-ok62havd author = Groß, Sonja title = SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications date = 2020-04-30 pages = extension = .txt mime = text/plain words = 4453 sentences = 252 flesch = 43 summary = COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS-CoV-2 while gaining time to explore and improve treatment options especially for cardiovascular disease (CVD) and immunocompromised patients, who appear to be at high-risk to die from cardiopulmonary failure. Since the coronavirus disease (COVID19) is still an emerging pandemic with more than 2.1 million confirmed cases worldwide [1] , special focus is currently directed towards the understanding of why people are hospitalized, receive intensive care, and frequently die as a consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. While higher mortality rates among CVD patients are also associated with other respiratory diseases (especially influenza virus-induced flu or previous SARS epidemics), the question was put forward, whether people treated for heart-related illness are more prone to SARS-CoV-2 viral infection, based on first epidemiological evidence, but particularly based on the presumed upregulation of the SARS-CoV-2 entry receptor. cache = ./cache/cord-280628-ok62havd.txt txt = ./txt/cord-280628-ok62havd.txt === reduce.pl bib === id = cord-280280-9jr7ekbu author = Bertoncelli, Deborah title = COVID19: potential cardiovascular issues in pediatric patients date = 2020-05-11 pages = extension = .txt mime = text/plain words = 3393 sentences = 181 flesch = 36 summary = Ongoing studies and accumulated data are detailing the features and the effects of the new coronavirus disease 19 (COVID 19) in the adult population, and cardiovascular involvement is emerging as the most significant and life-threatening complication, with an increased risk of morbidity and mortality in patients with underlying cardiovascular disease. At present, though the limited data on the effects of COVID 19 in pediatric patients, children seem to count for a little proportion of SARS-COV 2 infection, and present with less severe disease and effects However infants and toddlers are at risk of developing critical course. Coronavirus disease 19 (COVID-19) is a severe acute respiratory syndrome for which the etiologic agent is the novel beta coronavirus SARS-CoV-2, first described in December 2019 in China in a cluster of patients presenting with pneumonia. The main presenting clinical feature of the disease is pneumonia, ranging from asymptomatic or mildly symptomatic to severe acute respiratory distress syndrome, but cardiovascular involvement is emerging as one of the most significant and life-threatening complications of SARS-CoV-2 infection (1, 2) . cache = ./cache/cord-280280-9jr7ekbu.txt txt = ./txt/cord-280280-9jr7ekbu.txt === reduce.pl bib === id = cord-280111-6hiuzkvz author = Maspero, Cinzia title = Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic date = 2020-06-17 pages = extension = .txt mime = text/plain words = 6913 sentences = 358 flesch = 44 summary = This literature review aims at reducing in-office appointments by providing an overview of the technologies available and their reliability in the long-distance monitoring of patients, i.e., teledentistry. As no reviews have yet been carried out on the efficacy of teleassistance in orthodontics as a way to manage patients at a distance, we would like to report on the evidence available as to the possibility of implementing new technologies in teleassistance, generally known by teleorthodontics to help during the COVID-19 pandemic to remotely monitor patients' conditions. The attitudes toward teleassistance in orthodontics, and in general, dentistry by respective dental care professionals, was investigated in several studies which confirmed it was as an effective alternative to in-office visits for several routine procedures and to make consultations more accessible to dentists and patients [23, 38] . cache = ./cache/cord-280111-6hiuzkvz.txt txt = ./txt/cord-280111-6hiuzkvz.txt === reduce.pl bib === id = cord-280060-gzby85u9 author = Rello, Jordi title = Management of infections in critically ill returning travellers in the intensive care unit—II: clinical syndromes and special considerations in immunocompromised patients() date = 2016-04-28 pages = extension = .txt mime = text/plain words = 5493 sentences = 297 flesch = 38 summary = 2 A International Journal of Infectious Diseases 48 (2016) 104-112 significant number of immunocompromised patients may also be migrants who may return to their countries of origin to visit friends and relatives, and may acquire travel-associated infections. 26 Cases of Chagas disease (Trypanosoma cruzi) either as a consequence of reactivation of a latent infection not identified at the time of transplant (because an unrecorded travel history or stay in an endemic area) or by transmission through the organ donor, can also be associated with a high mortality. There have also been case reports of severe disease from other travel-associated infections, such as salmonellosis, Vibrio parahaemolyticus, and visceral leishmaniasis in immunocompromised patients. Less common pathogens such as Staphylococcus aureus, avian influenza viruses such as H7N9 and H5N1, the Middle East respiratory syndrome coronavirus (MERS-CoV), and Gram-negative rods such as Burkholderia pseudomallei must also be considered, as well as a few other pathogens that do not usually cause pneumonia, such as malaria. cache = ./cache/cord-280060-gzby85u9.txt txt = ./txt/cord-280060-gzby85u9.txt === reduce.pl bib === id = cord-280360-rh37d5wc author = Gibson, David S. title = Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease date = 2009-05-02 pages = extension = .txt mime = text/plain words = 8297 sentences = 388 flesch = 41 summary = title: Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis -Proteomic patterns of joint inflammation in early stage disease 1 We initially performed a study of the proteins expressed within synovial fluid and plasma in early JIA in order to discover novel biomarkers which distinguish between local and systemic components of joint inflammation in arthritis. The simultaneous analysis of individual paired plasma and synovial fluids from ten patients ( Table 1 , study group A) was used to initially isolate joint-specific protein expression profiles, without introducing bias from inter-individual differences. A number of proteins with consistent synovial and plasma 'specific' expression patterns are highlighted and quantified to demonstrate the ability to reliably differentiate molecular fingerprints of local and systemic disease across patient groups by this gel based approach. cache = ./cache/cord-280360-rh37d5wc.txt txt = ./txt/cord-280360-rh37d5wc.txt === reduce.pl bib === id = cord-280348-vrnxucye author = Argano, Christiano title = Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry date = 2020-07-27 pages = extension = .txt mime = text/plain words = 4641 sentences = 257 flesch = 39 summary = Chronic obstructive pulmonary disease (COPD) represents an important leading cause of morbidity and mortality with high economic and social costs: according to the WHO, COPD is the fourth most common cause of death worldwide, and it is estimated to be the third by 2020; furthermore, the global burden of COPD is expected to increase in the coming years, due to the prevalence of smoking and aging of the world population [1] . The following clinical characteristics were evaluated: respiratory and non-respiratory disease distribution at hospital admission (according to International Classification of Diseases-Ninth Revision); cognitive status and mood disorders (by the Short-Blessed-Test [SBT] [9] and the Geriatric-Depression-Scale [GDS] [10] ,respectively; performance in activities of daily living at hospital admission (measured by means of the Barthel Index [BI] [11] ; severity and comorbidity index(assessed by the Cumulative-Illness-Rating-Scale CIRS-s and CIRS-c, respectively) [12] , glomerular filtration rate (using the Chronic Kidney Disease Epidemiology Collaboration-formula [13] ), length of hospital stay, drugs prescriptions (at admission, discharge, at 3 and 12 months follow-up), destination at discharge, in-hospital and 3-month and 1-year mortality rate. cache = ./cache/cord-280348-vrnxucye.txt txt = ./txt/cord-280348-vrnxucye.txt === reduce.pl bib === id = cord-280848-z0sbztkw author = Setzen, Michael title = COVID-19 and rhinology: A look at the future date = 2020-04-15 pages = extension = .txt mime = text/plain words = 2882 sentences = 133 flesch = 47 summary = These include protocols pertinent to safety, in-office Rhinologic procedures, the substitution of imaging for endoscopy, and understanding the appropriate role of telemedicine. There has been controversy and significant concern regarding endoscopic evaluation of patients in the office, especially nasal endoscopy and flexible laryngoscopy, since performing these procedures puts one in direct contact with the virus as it resides primarily in nose and nasopharynx. To decrease nasal endoscopy procedures and minimize risk, organizations such as the American Rhinologic Society (ARS) should consider guidelines examining when it is appropriate to go straight to CT in select cases of possible COVID-19 now and in the future. In-Office CT sinus will continue to play an important role as a point of service procedure in lieu of nasal endoscopy in patients with COVID-19 or suspected thereof. This makes nasal endoscopy and other in-office rhinologic procedures a concern for the Otolaryngologist with increased risk for infection. cache = ./cache/cord-280848-z0sbztkw.txt txt = ./txt/cord-280848-z0sbztkw.txt === reduce.pl bib === id = cord-280030-neqycg6v author = Sewlall, Nivesh H. title = Clinical Features and Patient Management of Lujo Hemorrhagic Fever date = 2014-11-13 pages = extension = .txt mime = text/plain words = 6567 sentences = 339 flesch = 49 summary = BACKGROUND: In 2008 a nosocomial outbreak of five cases of viral hemorrhagic fever due to a novel arenavirus, Lujo virus, occurred in Johannesburg, South Africa. Distinctive treatment components of the one surviving patient included rapid commencement of the antiviral drug ribavirin and administration of HMG-CoA reductase inhibitors (statins), N-acetylcysteine, and recombinant factor VIIa. CONCLUSIONS: Lujo virus causes a clinical syndrome remarkably similar to Lassa fever. We describe the clinical features of the five recognized cases of Lujo hemorrhagic fever (LHF) in the 2008 outbreak in South Africa and summarize their clinical management, as well as providing additional epidemiologic detail, with a focus on the risks for secondary transmission. In 2008, an outbreak of a novel hemorrhagic fever virus called Lujo occurred in Johannesburg, South Africa, with secondary transmission from the index patient to four healthcare workers. cache = ./cache/cord-280030-neqycg6v.txt txt = ./txt/cord-280030-neqycg6v.txt === reduce.pl bib === id = cord-280233-avmisu31 author = Chase, J. Geoffrey title = Safe doubling of ventilator capacity: a last resort proposal for last resorts date = 2020-05-14 pages = extension = .txt mime = text/plain words = 1641 sentences = 105 flesch = 54 summary = In light of the COVID-19 pandemic, this commonsense approach was recently clarified in a SCCM-ASA-AARC-AACN-ASPF-CHEST consensus statement on the Society of Critical Care Medicine (SCCM) website [1] : 'We recommend that clinicians do not attempt to ventilate more than one patient with a single ventilator while any clinically proven, safe, and reliable therapy remains available (ie, in a dire, temporary emergency)' [1] . In-parallel is a critical point, as inspiration and expiration all take place at the same time, so there is thus no change to respiratory rate (RR) and tidal volume or driving pressure are adjusted for the number of patients. Instead of the same RR and higher tidal volume or driving pressure, in-series breathing doubles the RR and keeps the other ventilator settings the same. PC driving pressure and VC tidal volume would have to be the same as ventilators currently do not have the capability to enable alternating breath settings. cache = ./cache/cord-280233-avmisu31.txt txt = ./txt/cord-280233-avmisu31.txt === reduce.pl bib === id = cord-280241-h16s6wwm author = McStay, R. title = COVID-19: looking beyond the peak. Challenges and tips for radiologists in follow-up of a novel patient cohort date = 2020-10-08 pages = extension = .txt mime = text/plain words = 4857 sentences = 215 flesch = 40 summary = Following on from initial statements in the acute phase of the pandemic (1) (2), this update from the British Society of Thoracic Imaging group aims to provide an overview of the multisystem complications of COVID-19 with a focus on the thoracic manifestations, in particular the lung parenchymal and pulmonary vascular sequelae. The authors will also explore the British Thoracic Society (BTS) guidance on the respiratory follow-up of patients with COVID-19, including the resource implications for departments, discuss the potential use of structured reporting of follow-up imaging and outline future opportunities for longitudinal data collection and research. A perilobular pattern of organising pneumonia (32) , recognised in the acute phase of the disease, may also be present on follow-up but may dissipate on later imaging, especially if unaccompanied by signs of fibrosis (Fig. 10) . cache = ./cache/cord-280241-h16s6wwm.txt txt = ./txt/cord-280241-h16s6wwm.txt === reduce.pl bib === id = cord-280821-kc0ut4oy author = Venturini, Elisabetta title = Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date = 2020-09-24 pages = extension = .txt mime = text/plain words = 5481 sentences = 315 flesch = 45 summary = The Italian Society of Pediatric Infectious Diseases steering and scientific committee developed a position paper on treatment of children with COVID-19, reviewing the current literature on this topic and providing indications based on the available literature data. Currently, American guidelines on COVID-19 treatment published in May 2020, recommend both in children and adults to use lopinavir/ritonavir only in the context of clinical trials, given the lack of effectiveness reported now in literature [9, 12] . The latest Chinese guidelines on SARS-Cov-2 pneumoniae do not recommend the use of a specific antiviral for the treatment of COVID-19, and nevertheless include lopinavir/ritonavir among the available therapeutic options for hospitalized patients [29] . In May 2020, following an assessment of the emergency use authorization criteria and available scientific evidence, the FDA issued an emergency use authorization allowing for the administration of remdesivir intravenously by health care providers for the treatment of COVID-19 suspected or laboratoryconfirmed in adults and pediatric patients hospitalized with severe disease [34] . cache = ./cache/cord-280821-kc0ut4oy.txt txt = ./txt/cord-280821-kc0ut4oy.txt === reduce.pl bib === id = cord-280984-2j8ckz14 author = Roux, CH title = Impact of home confinement during the COVID‐19 pandemic on medication use and disease activity in spondyloarthritis patients date = 2020-06-17 pages = extension = .txt mime = text/plain words = 788 sentences = 57 flesch = 46 summary = title: Impact of home confinement during the COVID‐19 pandemic on medication use and disease activity in spondyloarthritis patients Home confinement, imposed as part of the social distancing measures in the fight against the coronavirus disease 2019 (COVID‐19), poses several problems for patients with spondyloarthritis (SpA), including the lack of physical activity, psychological factors, and the confusion related to the prescriptions of NSAIDs. We investigated the impact of confinement on the medication intake and disease activity in SpA patients in a questionnaire‐based survey. We investigated the impact of confinement on the medication intake and disease activity in SpA patients in a questionnaire-based survey. However, this is the first study providing information on therapy compliance during home confinement and the frequency of COVID-19 in SpA patients. Thus, this survey shows that home confinement linked to the COVID-19 pandemic is associated with worsening of the disease and a reduction or suspension of medication intake, in particular NSAIDs, in SpA patients. cache = ./cache/cord-280984-2j8ckz14.txt txt = ./txt/cord-280984-2j8ckz14.txt === reduce.pl bib === id = cord-280996-anq680a1 author = Agarwal, Arnav title = High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission date = 2020-06-15 pages = extension = .txt mime = text/plain words = 7117 sentences = 383 flesch = 42 summary = title: High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission Review 1: we synthesized results from randomized-controlled trials (RCTs) comparing HFNC to conventional oxygen therapy (COT) in critically ill patients with acute hypoxemic respiratory failure. Conclusions High-flow nasal cannula may reduce the need for invasive ventilation and escalation of therapy compared with COT in COVID-19 patients with acute hypoxemic respiratory failure. Conclusions High-flow nasal cannula may reduce the need for invasive ventilation and escalation of therapy compared with COT in COVID-19 patients with acute hypoxemic respiratory failure. We conducted two rapid systematic reviews commissioned by the WHO to summarize the evidence for the efficacy, safety, and risk of aerosol generation and infection transmission during HFNC use among patients with acute hypoxemic respiratory failure due to COVID-19. cache = ./cache/cord-280996-anq680a1.txt txt = ./txt/cord-280996-anq680a1.txt === reduce.pl bib === id = cord-280961-fka8c69p author = Zhang, Rui title = CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city date = 2020-04-11 pages = extension = .txt mime = text/plain words = 3651 sentences = 211 flesch = 50 summary = METHODS: This was a retrospective analysis of the clinical and thoracic CT features of 120 consecutive patients with confirmed SARS-CoV-2 pneumonia admitted to a tertiary university hospital between January 10 and February 10, 2020, in Wuhan city, China. (c) Unenhanced axial CT images of a 27-year-old male doctor with a history of exposure to confirmed SARS-CoV-2 patients, initially presenting with fever (39°C), nonproductive cough, dyspnea, and myalgia (c1) who progressed to a severe case requiring oxygen supplementation (c2). (d) Unenhanced axial CT images of a 52-year-old male doctor with asthma and exposure to confirmed SARS-CoV-2 patients, initially presenting with fever (39°C), non-productive cough, dyspnea, and myalgia who rapidly progressed to a severe form requiring mechanical ventilation. In this study, we reported the clinical characteristics and chest CT findings at presentation for all types of SARS-CoV-2 pneumonia severity. cache = ./cache/cord-280961-fka8c69p.txt txt = ./txt/cord-280961-fka8c69p.txt === reduce.pl bib === id = cord-280431-tuzdng4h author = Alinier, Guillaume title = 5 Basing a Nonclinician's Career upon Simulation The Personal Experience of a Physicist date = 2008-12-31 pages = extension = .txt mime = text/plain words = 3506 sentences = 149 flesch = 41 summary = The triggers for this rapid growth have not only been recent technological developments in terms of personal computer power, but primarily clinical educators believing in the potential of simulation training approaches to help others effectively acquire life-saving skills in a safe and controlled environment. At the same time, I assumed responsibility for the development of the University of Hertfordshire's Intensive Care and Emergency Simulation Center concentrating primarily on delivering simulation-based training to nursing and paramedical students and evaluating the teaching effectiveness of this approach [6] . Similarly, you can greatly contribute to the success of your center's simulation programs by effectively communicating with other educators to refine scenarios provided to your participants, develop the simulation environment and new props. You might be able to use your skills and technical knowledge to further develop their ideas and improve aspects of the simulation training experience of participants. cache = ./cache/cord-280431-tuzdng4h.txt txt = ./txt/cord-280431-tuzdng4h.txt === reduce.pl bib === id = cord-280944-uphs5gvl author = Stagnell, S. title = COVID and consent date = 2020-07-10 pages = extension = .txt mime = text/plain words = 872 sentences = 54 flesch = 54 summary = Sir, current guidance from the RCS Recommendations for paediatric dentistry during the COVID-19 pandemic is very clear: ' Access to general anaesthesia will be significantly reduced for the foreseeable future' . Sir, prior to the COVID-19 pandemic, patients undergoing invasive procedures were subject to confirming their consent through written means, a process which is considered common within surgical fields. 1 The guidance issued by the FGDP on 1 June suggested a move towards provision of 'digital packs' and it seems many standard operating procedures (SOPs) being issued by practices include the provision of digital information packs with consent forms to patients. With dental practices now resuming a limited level of practice and possibly experiencing the level of frustrations with lack of treatment provisions for anxious patients, oral sedation with Diazepam is an invaluable tool in enabling patients the access to care they require. Careful case selection is of course key to its successful use, and requires the triaging clinician to be thorough in ascertaining dental history and indication of sedation need. cache = ./cache/cord-280944-uphs5gvl.txt txt = ./txt/cord-280944-uphs5gvl.txt === reduce.pl bib === id = cord-281060-1ud5hzlh author = Méndez Maestro, Irune title = Skin manifestations in patients hospitalized with confirmed COVID‐19 disease: a cross‐sectional study in a tertiary hospital date = 2020-09-24 pages = extension = .txt mime = text/plain words = 1588 sentences = 104 flesch = 49 summary = BACKGROUND: COVID‐19 cutaneous manifestations have been recently described and classified in five different clinical patterns, including acral erythema‐edema (pseudo‐chilblain), maculopapular exanthemas, vesicular eruptions, urticarial lesions, and livedo or necrosis. We decided to perform this study to describe the real prevalence and directly examine the skin findings in hospitalized patients in our institution with a confirmed diagnosis of COVID-19 disease. We performed a cross-sectional study, which included COVID19 Based on recent reports 4-16 and on the Spanish group classification in clinical patterns, 17 we included acral erythemaedema (pseudo-chilblain), maculopapular exanthemas, vesicular eruptions, urticarial lesions, and livedo or necrosis areas. All skin findings can be included in the recently described clinical patterns of cutaneous manifestations of COVID-19 disease. In our study, we did not correlate the severity of the COVID-19 disease with the different skin patterns because all of the patients we included had very similar clinical characteristics of COVID-19 (moderate-severe infection that required hospitalization). cache = ./cache/cord-281060-1ud5hzlh.txt txt = ./txt/cord-281060-1ud5hzlh.txt === reduce.pl bib === id = cord-281130-9tawihti author = Schirinzi, Annalisa title = Pentraxin 3: Potential prognostic role in SARS-CoV-2 patients admitted to the emergency department date = 2020-11-02 pages = extension = .txt mime = text/plain words = 1037 sentences = 58 flesch = 49 summary = (4) that evaluated the role of complement related pattern recognition molecules, including C-reactive protein (CRP) and Pentraxin 3 (PTX3), as markers of short-term mortality in intensive care patients. In order to evaluate the potential prognostic value of PTX3 and its correlation with the severity of SARS-CoV-2, measurement of PTX3 in serum samples of patients (n= 75, male/female 47/28, age 69 years (median) 59-75 years (IQR)) with COVID-19 microbiology proven infection (from March to May 2020) was carried out using an enzyme-linked immunosorbent assay (ELISA) (DSX, Technogenetics srl, Milano, Italy), in addition to routine laboratory tests performed at admission. Moreover, PTX3 correlated (Spearman test) with some inflammation biochemical parameters commonly evaluated in SARS-CoV-2 patients, in particular with IL-6 (r =0.69, p<0.001), PCT (r =0.52, p<0.001), PSP (r =0.52, p<0.001), LDH (r =0.62, p<0.001), CRP (r =0.59, p<0.001), and D-dimer (r =0.43, p<0.001). Taken together, data obtained from our preliminary study suggest a potential prognostic role of PTX3 in SARS-CoV-2 patients, with higher levels associated with poor outcome. cache = ./cache/cord-281130-9tawihti.txt txt = ./txt/cord-281130-9tawihti.txt === reduce.pl bib === id = cord-281003-7pdhxdzc author = Farmakis, Dimitrios title = COVID‐19 and thalassaemia: A position statement of the Thalassaemia International Federation date = 2020-07-13 pages = extension = .txt mime = text/plain words = 2829 sentences = 159 flesch = 44 summary = METHODS: The present statement summarizes the key challenges concerning the management of haemoglobinopathies, with particular focus on patients with either transfusion‐dependent or non‐transfusion‐dependent thalassaemia, identifies the gaps in knowledge and suggests measures and strategies to deal with the pandemic, based on available evidence and expert opinions. The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected millions across the world, having caused hundreds of thousands deaths. However, disease-related complications may affect multiple organs including the heart, liver, endocrine glands, lungs and the immune system, thus rendering this patient population at an increased risk to develop serious complications during COVID-19. 2, 3, 11 This is especially so in patients who receive suboptimal management and lack access to modern therapy and Thalassaemia patients do not have the same risk of pulmonary infections with sickle cell disease patients but, they may have multiple organ complications, often due to iron overload, including cardiac and hepatic, diabetes mellitus and endocrine disease. cache = ./cache/cord-281003-7pdhxdzc.txt txt = ./txt/cord-281003-7pdhxdzc.txt === reduce.pl bib === id = cord-280551-9hoxy5ok author = Kim, Donghee title = Predictors of Outcomes of COVID-19 in Patients with Chronic Liver Disease: US Multi-center Study date = 2020-09-17 pages = extension = .txt mime = text/plain words = 3585 sentences = 189 flesch = 49 summary = We performed survival analysis to identify independent predictors of all-cause mortality and COVID-19 related mortality, and multivariate logistic regression to determine the risk of severe COVID-19 in patients with CLD. The liver-specific factors associated with independent risk of higher overall mortality were alcohol-related liver disease (ALD) (hazard ratio [HR] 2.42, 95% confidence interval [CI] 1.29-4.55), decompensated cirrhosis (HR 2.91 [1.70-5.00]) and hepatocellular carcinoma (HCC) (HR 3.31 [1.53-7.16]). Future studies will be needed to analyze specific subgroups within the spectrum of alcohol liver disease (ALD) who are at higher risk for adverse outcomes with COVID-19. We identify decompensated cirrhosis, ALD, and HCC to be determinants of mortality in patients with CLD, and additionally show that Hispanic ethnicity is independently associated with severe COVID-19. In this large study of 867 patients from 21 centers across the US with CLD with COVID-19 we determine that patients with alcohol related liver disease (ALD), decompensated cirrhosis and hepatocellular carcinoma have a high risk for allcause mortality from COVID-19. cache = ./cache/cord-280551-9hoxy5ok.txt txt = ./txt/cord-280551-9hoxy5ok.txt === reduce.pl bib === id = cord-280794-k591vqji author = Bauer, Melissa E. title = Neuraxial Procedures in COVID-19–Positive Parturients: A Review of Current Reports date = 2020-04-20 pages = extension = .txt mime = text/plain words = 837 sentences = 59 flesch = 43 summary = Because anesthesiologists must take into account the risk of meningitis or encephalitis associated with neuraxial procedures in the setting of untreated viremia, we reviewed publications reporting outcomes in COVID-19-positive pregnant women in the current pandemic in an attempt to address this concern. In general, the risk of causing meningitis or encephalitis is extremely low with neuraxial procedures, even in infected patients. Before performing a neuraxial procedure in these patients, it would be advisable to review a recent platelet count given that one-third of patients with COVID-19 infection have been reported to have thrombocytopenia compared with 7%-12% of patients during pregnancy alone. 7 In pregnant women, a platelet count of 70,000 × 10 6 /L has a low risk for spinal epidural hematoma, and lower levels should be considered in cases such as these with a high risk for respiratory compromise with general anesthesia. cache = ./cache/cord-280794-k591vqji.txt txt = ./txt/cord-280794-k591vqji.txt === reduce.pl bib === id = cord-280554-9jp85yzz author = Lamure, Sylvain title = Determinants of outcome in Covid-19 hospitalized patients with lymphoma: A retrospective multicentric cohort study date = 2020-10-13 pages = extension = .txt mime = text/plain words = 4536 sentences = 225 flesch = 48 summary = The data obtained concerning lymphoma history included the date of diagnosis, pathological classification according to the WHO classification for lymphoid neoplasms [19] , number of treatment lines, past autologous or allogeneic stem cell transplant, chimeric antigen receptor (CAR) T-cell therapy, detailed bendamustine and anti-CD20 monoclonal antibody use (date of first and last administration), and lymphoma status at admission for Covid-19 (complete or partial remission, diagnosed at admission, under first or second line treatment, in watch and wait follow-up, or refractory/ relapsed). Covariates considered in this analysis were age ( 70 years versus below), gender, BMI ( 30 kg/m 2 versus below), smoking status, presence of comorbidities (overall or hypertension, diabetes, chronic lung disease, or past history of cancer) and ongoing antihypertensive treatment with an ACE inhibitor or angiotensin-receptor blocker (ARB), main lymphoma subtypes (Hodgkin lymphoma, B-cell non-Hodgkin lymphoma (NHL), or T-cell NHL), recent administration of corticosteroids (within one month), use of bendamustine (within one year), or anti-CD20 monoclonal antibody (within one year), time between diagnosis of lymphoma and hospitalization for Covid-19 (< 2 years versus 2 years), past history of autologous stem cell transplant, and lymphoma status (refractory/relapsed versus others). cache = ./cache/cord-280554-9jp85yzz.txt txt = ./txt/cord-280554-9jp85yzz.txt === reduce.pl bib === id = cord-281039-a7q5nzwn author = Rodilla, Enrique title = Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 date = 2020-09-28 pages = extension = .txt mime = text/plain words = 4806 sentences = 246 flesch = 45 summary = Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). First, a previous diagnosis of HT increased the risk of all-cause death in COVID-19 patients who required hospitalization on the order of approximately 20% and independently of age and other cardiovascular comorbidities, such as HF and atrial fibrillation. Second, previous treatment with ACEIs/ARBs in hypertensive patients was not associated with a higher risk of all-cause mortality in hypertensive hospitalized COVID-19 patients compared to other antihypertensive drugs. cache = ./cache/cord-281039-a7q5nzwn.txt txt = ./txt/cord-281039-a7q5nzwn.txt === reduce.pl bib === id = cord-280358-ru2hv6pz author = Auvinen, R. title = Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients: a prospective observational study date = 2020-06-29 pages = extension = .txt mime = text/plain words = 4219 sentences = 271 flesch = 50 summary = title: Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients: a prospective observational study Objective We compared the clinical characteristics, findings and outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) or influenza to detect relevant differences. Our prospective population-based influenza study was already recruiting hospitalized adult patients with severe acute respiratory infection (SARI), which gave us the opportunity to enroll COVID-19 patients since the beginning of the outbreak. In previous studies, along with age and other comorbidities, obesity has been a risk factor for severe disease and ICU admission in both COVID-19 and influenza, which supports our findings [30, 31] . . https://doi.org/10.1101/2020.06.29.20140632 doi: medRxiv preprint epidemic, occasionally SARS-CoV-2 detection alone was conducted without influenza testing on clinical grounds, however, of the COVID-19 patients included in this study, 21 (75%) were tested for influenza and no co-infections were found. cache = ./cache/cord-280358-ru2hv6pz.txt txt = ./txt/cord-280358-ru2hv6pz.txt === reduce.pl bib === id = cord-281064-b69p44uq author = Ozder, Aclan title = A Novel Indicator Predicts 2019 Novel Coronavirus Infection in Subjects with Diabetes date = 2020-07-03 pages = extension = .txt mime = text/plain words = 3499 sentences = 195 flesch = 51 summary = Analysis of 11 studies regarding laboratory abnormalities in patients with COVID-19 did not mention raised blood glucose or diabetes as predictor of severe disease [12] . Previous results of complete blood count of the enrolled same non-diabetic individuals with Covid infection which were studied during their last visit to any out-patient clinic at the hospital before onset of Covid infection were yielded from the archive records via patient information management system of the hospital. The MPV values of age-and sex-matched 160 laboratory confirmed Covid patients without diabetes admitted to the Covid out-patient clinic were detected as 10.49 ± 0.96 and 10.66 ± 0.94 before and after Covid infection in these individuals, respectively (p=0.37). We thought that the statistically significant difference in MPV between diabetic patients before onset of Covid infection and healthy individuals was caused by hyperglycemia in diabetes. cache = ./cache/cord-281064-b69p44uq.txt txt = ./txt/cord-281064-b69p44uq.txt === reduce.pl bib === id = cord-281276-rffp6qe2 author = Rhazi, Karima El title = Ethical issues related to the hydroxychloroquine treatment prescription for Covid-19 date = 2020-06-17 pages = extension = .txt mime = text/plain words = 3414 sentences = 186 flesch = 50 summary = The paper conclude that, since health authorities in some countries recommended this off-label use treatment, physicians are challenged by the requirement of veracity while providing care to their patients and the implications of such a requirement; they are facing the challenge of balancing this guideline and their own conviction. To date and after the fifth months into the novel coronavirus pandemic, no drugs have demonstrated safety and efficacy in randomized controlled trials for patients with COVID-19. This decision has raised many questions and some ethical issues related to the hydroxychloroquine treatment prescription might emerge during the Covid-19 patients' management. Reluctancy regarding the use of this drug for the treatment of patients with Covid-19 is justified by the absence of a high level of scientific evidence namely randomized controlled clinical trials proving the superiority of this drug for this indication, as we discussed above. cache = ./cache/cord-281276-rffp6qe2.txt txt = ./txt/cord-281276-rffp6qe2.txt === reduce.pl bib === id = cord-281283-h6yai7sx author = Ma, Jun title = Emergency response strategy for containing COVID-19 within a psychiatric specialty hospital in the epicenter of the COVID-19 epidemic in China date = 2020-08-04 pages = extension = .txt mime = text/plain words = 2194 sentences = 108 flesch = 40 summary = Because SARS-CoV-2 is highly infectious, and the general population is susceptible, it is difficult to effectively prevent the spread of COVID-19 based on the current instruments, medical staff, and management modes of mental health institutions. On February 13, the Wuhan epidemic prevention and control command instructed that an isolation ward should be established to treat patients with mental illnesses with confirmed or suspected of COVID-19 infection. During the outbreak, all impairmentspecific settings were replanned to allow for the most effective prevention and control of COVID-19, and the functions of the psychiatric wards were reallocated according to the following plan 9 : (1) a ward for confirmed COVID-19 patients: this ward is used for the treatment of COVID-19 patients, and the patients are classified and managed according to disease severity; secondary protections should be implemented. cache = ./cache/cord-281283-h6yai7sx.txt txt = ./txt/cord-281283-h6yai7sx.txt === reduce.pl bib === id = cord-281175-og3myz22 author = Tapper, Elliot B. title = The COVID-19 pandemic will have a long-lasting impact on the quality of cirrhosis care date = 2020-04-13 pages = extension = .txt mime = text/plain words = 2675 sentences = 156 flesch = 43 summary = The coronavirus disease 2019 (COVID-19) pandemic has shattered the meticulously developed processes by which we delivered quality care for patients with cirrhosis. We describe how this impact unfolds over 3 waves; i) an intense period with prioritized high-acuity care with delayed elective procedures and routine care during physical distancing, ii) a challenging 'return to normal' following the end of physical distancing, with increased emergent decompensations, morbidity, and systems of care overwhelmed by the backlog of deferred care, and iii) a protracted period of suboptimal outcomes characterized by missed diagnoses, progressive disease and loss to follow-up. This includes an intensification of the preventative care provided to patients with compensated cirrhosis, proactive chronic disease management, robust telehealth programs, and a reorganization of care delivery to provide a full service of care with flexible clinical staffing. Coordination of care associated with survival and healthcare utilization in a population-based study of patients with cirrhosis cache = ./cache/cord-281175-og3myz22.txt txt = ./txt/cord-281175-og3myz22.txt === reduce.pl bib === id = cord-281106-vzb5xzza author = Zerwes, S. title = COVID-19-Infektion – Risiko für thrombembolische Komplikationen date = 2020-09-01 pages = extension = .txt mime = text/plain words = 1929 sentences = 204 flesch = 38 summary = According to current data, the risk of thromboembolic events in hospitalized COVID-19 patients is significantly increased, making thrombosis prophylaxis with low molecular weight or unfractionated heparin necessary. Neben den bekannten Ursachen der Thromboseentstehung, wurden bei der COVID-Erkrankung spezielle Pathomechanismen beobachtet, die zur Bildung von Thrombosen sowohl im venösen als auch im arteriellen System beitragen können. Auch wenn die Mechanismen noch nicht in Ihrer Gesamtheit erfasst sind, so ist bereits jetzt ersichtlich, dass die thrombembolischen Komplikationen im Zusammenhang mit dem SARS-CoV-2-Virus auf eine exzessive Inflammationsreaktion, Veränderung von Blutflusseigenschaften, direkte virusbedingte Thrombozytenaktivierung und Endothelschädigung zurückzuführen sind [3] . Diese Hypothese wird von nahezu allen bisher publizierten Arbeiten zu thrombembolischen Ereignissen bei COVID-19-Patienten postuliert und könnte eine Erklärung für die deutlich erhöhte Anzahl von TVT bieten [1, 7, 17, 28, 39] . Eine einheitliche Nomenklatur besteht noch nicht, die Pu-blikationmitdergrößtenSerie benennt es als "Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2" (PIMS-TS) [36] . cache = ./cache/cord-281106-vzb5xzza.txt txt = ./txt/cord-281106-vzb5xzza.txt === reduce.pl bib === id = cord-281332-5mddyv0n author = Wilson, Michael R. title = A novel cause of chronic viral meningoencephalitis: Cache Valley virus date = 2017-07-25 pages = extension = .txt mime = text/plain words = 4008 sentences = 232 flesch = 42 summary = Interpretation: Cache Valley virus, a mosquito-borne orthobunyavirus, has only been identified in 3 immunocompetent North American patients with acute neuroinvasive disease. This report demonstrates that metagenomic next generation sequencing allows for unbiased pathogen identification, the early detection of emerging viruses as they spread to new locales, and the discovery of novel disease phenotypes. This report demonstrates that metagenomic next generation sequencing allows for unbiased pathogen identification, the early detection of emerging viruses as they spread to new locales, and the discovery of novel disease phenotypes. Here, we report the effective deployment of metagenomic next generation sequencing (mNGS) to diagnose Cache Valley virus (CVV), a mosquito-borne orthobunyavirus, 4 in an Australian patient with a primary immunodeficiency suffering from chronic meningoencephalitis. 41 Because CVV is rarely identified as a cause of human disease and has not been reported in Australia previously, there are no traditional candidate-based diagnostic tests for this virus available in Australia. cache = ./cache/cord-281332-5mddyv0n.txt txt = ./txt/cord-281332-5mddyv0n.txt === reduce.pl bib === id = cord-281346-bjhdy8mg author = Palacios Cruz, M. title = COVID-19, a worldwide public health emergency() date = 2020-04-21 pages = extension = .txt mime = text/plain words = 3481 sentences = 190 flesch = 51 summary = This new species of coronavirus has been termed 2019-nCoV and has caused a considerable number of cases of infection and deaths in China and, to a growing degree, beyond China, becoming a worldwide public health emergency. 2019-nCoV has high homology to other pathogenic coronaviruses, such as those originating from bat-related zoonosis (SARS-CoV), which caused approximately 646 deaths in China at the start of the decade. 17 Moreover, a recently published study estimated that 95% of the cases of 2019-nCoV infections in Wuhan showed symptoms before the 12th of January 2020, 18,19 a fact that, combined with the virus' incubation period, suggests a high possibility of the disease's travelrelated propagation. According to the WHO, a suspected case involves a patient with severe acute respiratory infection (fever, cough, requiring hospitalization) and with no other etiology that completely explains the clinical presentation, as well as a history of travel or residence in China during the 14 days before symptom onset. cache = ./cache/cord-281346-bjhdy8mg.txt txt = ./txt/cord-281346-bjhdy8mg.txt === reduce.pl bib === id = cord-281561-r10y2sgb author = Tiwari, Nidhi title = Novel β-Coronavirus (SARS-CoV-2): Current and Future Aspects of Pharmacological Treatments date = 2020-08-27 pages = extension = .txt mime = text/plain words = 6877 sentences = 384 flesch = 45 summary = Another invitro study reported that Ribavirin, analogue of guanosine nucleotide having wide spectrum of antiviral activity, used along with LPV/RTV to treat SARS-COV-2 viral infection in china (ChiCTR2000029387) . reported remdesivir shows possible efficacy better as compared to placebo group in hospitalized patients for the treatment of SARS-CoV-2 virus. The effectiveness and safety concern of darunavir/cobicistat combination is being evaluated under development of clinical trials phase 3 by enrolling 30 COVID-19 patients and estimated completion of study on December 31, 2020. Recently, retrospective cohort study showed high dose of anakinra (5 mg/kg, BD,iv) produces beneficial and efficacious effects in 72% Covid-19 infected patients associated with ARDS (Cavalli et al., 2020) . Based on case study of patients with SARS-CoV2 infection and also confirmed severe pneumonia and ARDS treated with i.v. infusion of eculizumab along with anticoagulant therapy (Enoxaparin 4000 IU/day s.c), antiviral therapy (LPV 800 mg/day + RTV 200 mg/day), hydroxychloroquine 400 mg/day, ceftriaxone 2 g/day IV, vitamin C 6 g/day for 4 days. cache = ./cache/cord-281561-r10y2sgb.txt txt = ./txt/cord-281561-r10y2sgb.txt === reduce.pl bib === id = cord-281391-0qkku2jd author = Miller-Handley, Hilary title = Treatment Options for COVID-19 in Patients with Reduced or Absent Kidney Function date = 2020-09-17 pages = extension = .txt mime = text/plain words = 4720 sentences = 276 flesch = 47 summary = COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, was first identified in the Hubei Province of China in late 2019. Because of these findings, chloroquine and hydroxychloroquine were used as early therapies in the treatment of COVID-19, and its use was further propagated by a small, retrospective, biased study from France with 36 patients which showed decrease in viral burden, and improved outcomes in patients treated with hydroxychloroquine [17] . A retrospective study from the Veterans Affairs, looked at hospitalized patients who received hydroxychloroquine and showed no evidence that use of hydroxychloroquine reduced the risk of progression of disease including mechanical ventilation and death [20] . Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial cache = ./cache/cord-281391-0qkku2jd.txt txt = ./txt/cord-281391-0qkku2jd.txt === reduce.pl bib === id = cord-281752-64mrflcr author = Vespignani, Hervé title = Report of EEG Finding on Critically Ill Patients with COVID‐19 date = 2020-06-13 pages = extension = .txt mime = text/plain words = 2115 sentences = 116 flesch = 49 summary = Of the 26 patients studied, 5 patients had EEGs that showed Periodic Discharges (PD) consisting of high amplitude frontal monomorphic delta waves with absence of epileptic activity. However, the presence of the monomorphic biphasic high amplitude delta waves associated with occasional myoclonic muscular activity could also possibly be indicative of brain injury either related to anoxia, severe hypoxia, anesthesia, or the direct effects of COVID-19 itself. The reported onset of loss of consciousness or confusion and cognitive impairment in COVID-19 infected patients with EEGs revealing biphasic delta PDs may suggest an injury or localized brain defect attributed to encephalopathy related to a unique and acute CNS process. When hospitalized patients infected with SARS-CoV-2 (COVID-19) present with an unexplained loss of consciousness, confusion or altered mental status, impaired arousal, and abnormal paroxysmal movements (myoclonus), it is suggested that an EEG be performed as part of the diagnostic assessment of the patient to determine an etiology and to identify potentially treatable CNS disorders. cache = ./cache/cord-281752-64mrflcr.txt txt = ./txt/cord-281752-64mrflcr.txt === reduce.pl bib === id = cord-281887-b511bjdy author = Ribeiro, Reitan title = Perioperative Cancer Care in the Context of Limited Resources during the COVID-19 Pandemic: Brazilian Society of Surgical Oncology Recommendations date = 2020-09-26 pages = extension = .txt mime = text/plain words = 4739 sentences = 234 flesch = 45 summary = DISCUSSION: The rational use of resources to reduce the risk of surgical cancer patients being operated on during the incubation period of a corona virus infection is important in this context. CONCLUSIONS: We present a protocol, focused on the patients' outcomes, for safe and rational use of resources to reduce the risk of surgical cancer patients being operated on during the virus incubation period, in the context of areas with limited resources. Our objective was to present the Brazilian Society of Surgical Oncology (BSSO) protocol for rational use of resources and for reducing the risk of surgical cancer patients being operated on during the coronavirus incubation period, in the context of areas with limited resources, and focused on patient outcomes. In light of all the previous considerations, Table 3 presents our suggested protocol for the rational use of resources to reduce the risk of surgical cancer patients from being operated on during the COVID-19 incubation period, in the context of areas with limited resources. cache = ./cache/cord-281887-b511bjdy.txt txt = ./txt/cord-281887-b511bjdy.txt === reduce.pl bib === id = cord-281945-jvnjzjds author = Radnis, Caitlin title = Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia date = 2020-09-06 pages = extension = .txt mime = text/plain words = 2808 sentences = 155 flesch = 43 summary = Survivors of critical illness and ARDS often experience neurocognitive impairment but, to date, there is scant literature correlating radiographic hypoxic brain injury to hypoxemia related to ARDS. In this case series, we describe three cases of hypoxic brain injury seen on magnetic resonance imaging (MRI) in patients with hypoxemia secondary to COVID-19-related ARDS. Of patients with severe disease, approximately 16% had acute respiratory distress syndrome (ARDS), 14.5% required invasive mechanical ventilation, and 99% had pneumonia [4] . A recent autopsy case series found evidence of hypoxic changes in the brain tissue of patients who had succumbed to COVID-19, but there was no report of whether these patients developed ARDS, duration of mechanical ventilation if required, whether extracorporeal membrane oxygenation (ECMO) was used, presence or absence of cardiac arrest, or cause of death [21] . In this case series, we describe three cases of hypoxic brain injury seen on MRI, along with clinical correlations, in patients with hypoxemia secondary to COVID-19 related ARDS. cache = ./cache/cord-281945-jvnjzjds.txt txt = ./txt/cord-281945-jvnjzjds.txt === reduce.pl bib === id = cord-281344-iswbgqqe author = Jonker, Leonie T. title = Perioperative telemonitoring of older adults with cancer: Can we connect them all? date = 2020-09-04 pages = extension = .txt mime = text/plain words = 3935 sentences = 186 flesch = 37 summary = MATERIAL AND METHODS: This is a retrospective analysis of a prospective cohort study with older patients (≥ 65 years) undergoing cancer-related surgery, who were identified for a perioperative telemonitoring study. This study is a retrospective analysis of a prospective cohort study with older patients undergoing cancer-related surgery, who were identified for a perioperative telemonitoring study (Netherlands trial registration number: NL 8253) [19] . The twelve patients who were discharged to an SNF were significantly older (mean age 79.0 versus 73.6 years old [p = 0.01]), had a higher ASA classification (ASA 3-4 58% versus 29% [p = 0.05]), used more medication (% polypharmacy 92% versus 50% [p = 0.00]) and were more often living alone or in a nursing home before surgery (50% versus 30%, 17% versus 0% [p = 0.00]). The main barriers to older adults' participation in a perioperative telemonitoring study were lack of internet access at home, digital illiteracy, and a perceived high mental burden. cache = ./cache/cord-281344-iswbgqqe.txt txt = ./txt/cord-281344-iswbgqqe.txt === reduce.pl bib === id = cord-282183-k0pn0ie2 author = Spiezia, Luca title = More severe hypercoagulable state in acute COVID-19 pneumonia as compared to other pneumonia. date = 2020-10-01 pages = extension = .txt mime = text/plain words = 1724 sentences = 98 flesch = 43 summary = Interestingly, we and two other Italian groups recently reported hypercoagulable whole blood profiles in COVID-19 patients admitted to Intensive Care Units for acute respiratory failure [4] [5] [6] . Therefore, we aimed to study traditional and whole blood thromboelastometry profiles -via a ROTEM ® sigma apparatus (Instrumentation Laboratory Werfen, Barcelona, Spain) -in a group of patients consecutively admitted to Internal Medicine wards of Padova University Hospital for acute pneumonia: cases were COVID-19 patients with pneumonia and controls were patients with pneumonia from different etiology. Although several papers, including one by our group, have previously reported COVID-19-related hypercoagulability in patients admitted to Intensive Care Units 4-6 , the present study focuses more closely on the comparison of coagulation profiles between COVID-19 patients with acute pneumonia and non COVID-19 patients with acute pneumonia. cache = ./cache/cord-282183-k0pn0ie2.txt txt = ./txt/cord-282183-k0pn0ie2.txt === reduce.pl bib === id = cord-281566-6v5zfue6 author = Hamilos, Daniel L. title = Host-microbial interactions in patients with chronic rhinosinusitis date = 2013-11-28 pages = extension = .txt mime = text/plain words = 11724 sentences = 629 flesch = 37 summary = 12 Our group found that cultured airway epithelial cells from patients with CRSsNP had an exaggerated response to stimulation with the combination of double-stranded RNA (a Toll-like receptor [TLR] 3 agonist and surrogate for viral infection) plus cigarette smoke extract, with exaggerated production of RANTES and hBD-2. Ramanathan et al 3 showed that culturing human sinonasal epithelial cells in the presence of the T H 2 cytokines IL-4 or IL-13 for 36 hours reduced expression of antimicrobial innate immune genes by using real-time PCR, ELISA, and flow cytometry, including TLR9, hBD-2, and SP-A. This has been shown in cultured airway epithelial cells and dispersed T lymphocytes from NPs. Fungi are commonly detected in the attached mucus of sinus tissues in patients with CRS 47,165 and can induce eosinophil activation and degranulation. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells cache = ./cache/cord-281566-6v5zfue6.txt txt = ./txt/cord-281566-6v5zfue6.txt === reduce.pl bib === id = cord-281298-qheq9lc8 author = Merks, Piotr title = The legal extension of the role of pharmacists in light of the COVID-19 global pandemic date = 2020-06-12 pages = extension = .txt mime = text/plain words = 2154 sentences = 149 flesch = 48 summary = Some of the novel legal extensions aimed at aiding overloaded healthcare systems are as follows: authorisation to prepare hand and surface disinfectants, eligibility to renew chronic treatment prescriptions, as well as filling pro auctore and pro familia prescriptions by pharmacists, performing COVID-19, influenza, and Group A Streptococcus screening tests, and vaccine administration. The important role of pharmacies, which form an integral part of 43 the healthcare system, should be emphasised in the daily delivery of medicines, therapeutics, vaccines, and key health services to the public. The role of pharmacies in a crisis, such as the current pandemic, is of crucial importance because they are often the first and the last point of contact with the health care system for 48 patients who need reliable information and advice. [2] [3] [4] Pharmacists play an important role in patient care during a pandemic both in 51 community pharmacies 5, 6 and in the hospital setting. cache = ./cache/cord-281298-qheq9lc8.txt txt = ./txt/cord-281298-qheq9lc8.txt === reduce.pl bib === id = cord-282483-0zsvhoog author = Ghisa, Matteo title = Reorganization of the Functional Gastrointestinal Disorders Unit during the SARS-CoV-2 Outbreak - Practical Recommendations date = 2020-07-10 pages = extension = .txt mime = text/plain words = 663 sentences = 42 flesch = 46 summary = While endoscopy with biopsies and radiology remain our most effective weapons to identify or manage these disorders, procedures such as high-resolution manometry (HRM) and reflux monitoring are the most specialized techniques able to clarify unclear clinical scenarios and improve patients' management. If an appointment is necessary, the day before the visit, health care professionals (HCPs) should call the patients to confirm it and to ask questions A rapid and functional reorganization of all the activities of a motility laboratory is mandatory to maintain as good as possible the standards of care, to reduce risks for both patients and healthcare personnel and to leave resources available to tackle this pandemic. However, considering that the efficacy of herd immunity is uncertain, a vaccine is not yet available and another wave of infections may arrive, COVID-19 could become a long-term problem and therefore it is necessary to permanently integrate these services in our way of providing medical care. cache = ./cache/cord-282483-0zsvhoog.txt txt = ./txt/cord-282483-0zsvhoog.txt === reduce.pl bib === id = cord-282219-7kzbnymp author = Wu, Liu title = The effect of massage on the quality of life in patients recovering from COVID-19: A systematic review protocol date = 2020-06-05 pages = extension = .txt mime = text/plain words = 2455 sentences = 167 flesch = 50 summary = title: The effect of massage on the quality of life in patients recovering from COVID-19: A systematic review protocol Secondary outcomes were accompanying symptoms (such as myalgia, expectoration, stuffiness, runny nose, pharyngalgia, anhelation, chest distress, dyspnea, crackles, headache, nausea, vomiting, anorexia, diarrhea) disappear rate, negative COVID-19 results rate on 2 consecutive occasions (not on the same day), average hospitalization time, clinical curative effect, and improved quality of life. CONCLUSION: The conclusion of our study will provide evidence to judge whether massage is an effective intervention on the quality of life in patients recovering. [6] Coronaviruses (CoVs), mainly targeting human respiratory system, are responsible for health-threatening outbreaks including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome, and lastly coronavirus disease 2019 (COVID-19). We will include articles related to massage therapy of patients recovering from COVID-19. This article will use the evidence quality rating method to evaluate the results obtained from this analysis. cache = ./cache/cord-282219-7kzbnymp.txt txt = ./txt/cord-282219-7kzbnymp.txt === reduce.pl bib === id = cord-282097-a1pwq4fi author = Hoertel, N. title = Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study date = 2020-10-27 pages = extension = .txt mime = text/plain words = 4403 sentences = 248 flesch = 49 summary = When examining the association between the cumulative dose of dexamethasone received during the visit and the endpoint, we found that the administration of a cumulative dose between 60 mg to 150 mg among patients who required respiratory support was significantly associated with a lower risk of death in the crude, unadjusted analysis (HR, 0.28; SE, 0.58, p=0.028), the adjusted multivariable analysis (HR, 0.24; SE, 0.65, p=0.030), and in the univariate Cox regression model in the matched analytic sample (HR, 0.32; SE, 0.58, p=0.048), whereas no significant association was observed with a different dose. When examining the association between the cumulative dose of dexamethasone received during the visit and the endpoint, we found that the administration of a cumulative dose between 60 mg to 150 mg among patients who required respiratory support was significantly associated with a lower risk of death in the crude, unadjusted analysis (HR, 0.28; SE, 0.58, p=0.028), the adjusted multivariable analysis (HR, 0.24; SE, 0.65, p=0.030), and in the univariate Cox regression model in the matched analytic sample (HR, 0.32; SE, 0.58, p=0.048), whereas no significant association was observed with a different dose. cache = ./cache/cord-282097-a1pwq4fi.txt txt = ./txt/cord-282097-a1pwq4fi.txt === reduce.pl bib === id = cord-281729-z321pebe author = Santos, Cláudia title = Pathophysiology of acute fibrinous and organizing pneumonia – Clinical and morphological spectra date = 2019-05-02 pages = extension = .txt mime = text/plain words = 3045 sentences = 150 flesch = 36 summary = Three clinical cases of patients presenting severe lung disease requiring mechanical ventilation and prolonged intensive care fitted on the variable spectra of AFOP histopathology and had poor outcome: a 23 year-old women had AFOP in the context of antiphospholipid syndrome pulmonary compromise; a 35 year-old man developed a letal intensive care pneumonia with AFOP pattern registered in post-mortem biopsy; and a 79 year-old man died 21 days after intensive care unit treatment of a sub-pleural organizing pneumonia with intra-alveolar fibrin, seen in post-mortem biopsy. Reporting these three clinical cases had the purpose to highlight the acute presentation of AFOP as a particular lung disease more recently described, initially confused with pneumonia, running with severe respiratory failure and immediate need for mechanic ventilation, with no response to antibiotics or steroids. cache = ./cache/cord-281729-z321pebe.txt txt = ./txt/cord-281729-z321pebe.txt === reduce.pl bib === id = cord-282043-cs1oyohu author = Giustino, Gennaro title = Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC Focus Seminar date = 2020-10-27 pages = extension = .txt mime = text/plain words = 1923 sentences = 114 flesch = 27 summary = Both direct viral infection and indirect injury resulting from inflammation, endothelial activation, and microvascular thrombosis occur in the context of coronavirus disease 2019. Although originally believed to be a syndrome characterized by acute lung injury, respiratory failure, and death, it is now apparent that severe coronavirus disease 2019 (COVID-19) is further characterized by exuberant cytokinemia, with resultant endothelial inflammation, microvascular thrombosis, and multiorgan failure (2) . Myocardial injury can be detected in w25% of hospitalized patients with COVID-19 and is associated with an increased risk of mortality. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Acute myocardial injury in patients hospitalized with COVID-19 infection: a review Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 cache = ./cache/cord-282043-cs1oyohu.txt txt = ./txt/cord-282043-cs1oyohu.txt === reduce.pl bib === id = cord-281733-bsq0ewac author = Veyseh, Maedeh title = Left gonadal vein thrombosis in a patient with COVID-19-associated coagulopathy date = 2020-09-07 pages = extension = .txt mime = text/plain words = 2461 sentences = 169 flesch = 45 summary = We report an unusual case of ovarian vein thrombosis and pulmonary embolism associated with COVID-19 presenting with abdominal pain. We report an unusual case of ovarian vein thrombosis and pulmonary embolism associated with COVID-19 presenting with abdominal pain. To our knowledge, this is the first reported case of COVID-19 with absent respiratory symptoms and presentation with venous thrombosis in an unusual location. To our knowledge, this is the first reported case of COVID-19 with absent respiratory symptoms and presentation with venous thrombosis in an unusual location. 8 9 Our patient was distinctive in terms of presentation as she lacked the common respiratory symptoms, rather acute venous thrombosis in an unusual location prompted the diagnosis of COVID-19. 1 24 In summary, we present an interesting case with an unusual presentation of COVID-19 who presented with abdominal pain and no significant respiratory symptoms and was diagnosed with thrombosis of the left ovarian vein. cache = ./cache/cord-281733-bsq0ewac.txt txt = ./txt/cord-281733-bsq0ewac.txt === reduce.pl bib === id = cord-282660-9x937eus author = Muñoz Vives, Josep Maria title = Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study date = 2020-05-06 pages = extension = .txt mime = text/plain words = 3213 sentences = 173 flesch = 51 summary = title: Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study All patients who were ≥65 years of age, presented to the Emergency Department of the participating hospitals during this period with a diagnosis of proximal femoral fracture, and had a minimum follow-up of 10 days were included in the cohort. Included participants were patients ‡65 years of age presenting to the Emergency Department of the participating hospitals with the clinical and radiographic diagnosis of a proximal femoral fracture (31-A and 31-B according to the OTA/AO classification 19 ) from a low-energy mechanism from March 14, 2020 (on the day that the Spanish government declared a state of national alarm due to COVID-19 and the pandemic surpassed 2,000 patients and 50 deaths from COVID-19 in Spain) until April 4, 2020, with a minimum of 10 days of follow-up. cache = ./cache/cord-282660-9x937eus.txt txt = ./txt/cord-282660-9x937eus.txt === reduce.pl bib === id = cord-282361-gje78nb1 author = Gökce, Mehmet İlker title = How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE–IAU multicenter collaborative cohort study date = 2020-05-20 pages = extension = .txt mime = text/plain words = 3248 sentences = 154 flesch = 43 summary = In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic. Information on the type of the stone related conditions, management strategies, anesthesiologic evaluation, anesthesia methods, and any alterations related to COVID-19 pandemic was collected. Rate of preoperative testing, emergency procedures, conservative approaches and topical/regional anesthesia increased after 21 days. The primary end point of the study was to collect information on the type of the stone related conditions, management strategies, anesthesiologic evaluation, anesthesia methods, and any alterations related to COVID-19 pandemic. While some guidelines suggest PCR testing in suspicious cases, the guidelines for sections with a high likelihood of virus load, such as otolaryngology, suggest that it can be performed Fig. 2 Summary of preoperative additional testing, alteration in anesthesia method and stone related procedures in the European cohort in all patients [14] . cache = ./cache/cord-282361-gje78nb1.txt txt = ./txt/cord-282361-gje78nb1.txt === reduce.pl bib === id = cord-282589-xof56j98 author = Lopes, M. I. F. title = Beneficial effects of colchicine for moderate to severe COVID-19: an interim analysis of a randomized, double-blinded, placebo controlled clinical trial date = 2020-08-11 pages = extension = .txt mime = text/plain words = 3972 sentences = 200 flesch = 53 summary = We present the interim analysis of a single-center randomized, double-blinded, placebo controlled clinical trial of colchicine for the treatment of moderate to severe COVID-19, with 38 patients allocated 1:1 from April 11 to July 06, 2020. We conducted a randomized, double-blinded, placebo controlled clinical trial to evaluate the use of colchicine for the treatment of hospitalized patients with moderate to severe COVID-19. As secondary endpoints we assessed clinical and laboratory parameters: measures of serum CRP, serum LDH and relation neutrophil to lymphocyte of peripheral blood samples from day zero to day 7; the number, type, and severity of adverse events; frequency of interruption of the study protocol due to adverse events; and frequency of QT interval above 450 ms. Patients who received colchicine in this randomized, double-blinded, placebo controlled clinical trial presented better evolution in terms of the need for supplemental oxygen and the length of hospitalization. cache = ./cache/cord-282589-xof56j98.txt txt = ./txt/cord-282589-xof56j98.txt === reduce.pl bib === id = cord-281804-lhnw8jx5 author = Sonis, Jonathan D. title = Humanism in the Age of COVID-19: Renewing Focus on Communication and Compassion date = 2020-04-24 pages = extension = .txt mime = text/plain words = 1987 sentences = 99 flesch = 42 summary = While video and telephonic alternatives to bedside evaluation may facilitate communication with patients while maintaining physical separation to limit healthcare worker exposure and preserve PPE, these solutions may not be as effective in older patients, who commonly have hearing and visual impairment, challenges with manual dexterity due to arthritis, and cognitive impairment, all of which impede effective use of such technology. 22 Not only will reducing variability improve adherence to isolation and other outpatient management recommendations, but providing frontline staff with comprehensive, pre-written instructions reduces the work burden associated with individual patient discharges and allows for the inclusion of extended information surrounding expected disease course, follow-up planning, and support resources for those suffering from the psychological effects of isolation or requiring local resources such as access to food. cache = ./cache/cord-281804-lhnw8jx5.txt txt = ./txt/cord-281804-lhnw8jx5.txt === reduce.pl bib === id = cord-282535-gnuhjs32 author = Cook, Gordon title = Real‐world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID‐19 disease) in patients with Multiple Myeloma receiving systemic anti‐cancer therapy. date = 2020-05-21 pages = extension = .txt mime = text/plain words = 1301 sentences = 68 flesch = 50 summary = title: Real‐world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID‐19 disease) in patients with Multiple Myeloma receiving systemic anti‐cancer therapy. . The UK index case was identified on the 31 st of January, 2020 and given the rapid spread and high mortality rate of COVID-19, it is imperative to define the impact on patients with co-existing medical conditions (3) . Multiple Myeloma (MM), the second most common haematological malignancy, is a cancer of the mature B-cell lineage and is associated with both cellular and humoral immune dysfunction that renders patients susceptible to infections, especially of the respiratory tract (4) (5) (6) (7) . This coupled with a median age at presentation of 70 years in a population with frequent co-existing medical conditions, means the outcomes of MM patients infected with COVID-19 warrants particular attention. cache = ./cache/cord-282535-gnuhjs32.txt txt = ./txt/cord-282535-gnuhjs32.txt === reduce.pl bib === id = cord-282430-u5ukqc5z author = Fenton, Mark E. title = An Expanded COVID-19 Telemedicine Intermediate Care Model Using Repurposed Hotel Rooms date = 2020-10-15 pages = extension = .txt mime = text/plain words = 2172 sentences = 94 flesch = 38 summary = The Pleural Pressure Working Group's planned RECRUIT (Recruitment Assessed by Electrical Impedance Tomography: Feasibility, Correlation with Clinical Outcomes and Pilot Data on Personalised PEEP Selection) project (https:// www.plugwgroup.org/), which aims to compare the results of different bedside methods to titrate PEEP based on EIT, might provide us with some answers on how to titrate PEEP using EIT data. Bruni and colleagues have built the clinical care model around twice daily assessment of patients by a respiratory physician using remote monitoring (no details of how monitoring is done were included) (1). We really thank Fenton and colleagues for their interest in our article (1) and the pleasing comments regarding our telemedicine-supported hotel accommodation model for patients with coronavirus disease (COVID-19) . Electrical impedance tomography for positive end-expiratory pressure titration in COVID-19-related acute respiratory distress syndrome Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial cache = ./cache/cord-282430-u5ukqc5z.txt txt = ./txt/cord-282430-u5ukqc5z.txt === reduce.pl bib === id = cord-282021-m1lh7mzd author = El Shamy, Osama title = Telenephrology with Remote Peritoneal Dialysis Monitoring during Coronavirus Disease 19 date = 2020-04-28 pages = extension = .txt mime = text/plain words = 1569 sentences = 74 flesch = 48 summary = In California's COVID-19 epicenter, some Silicon Valley hospitals place emphasis on data privacy, main-El Shamy/Tran/Sharma/Ronco/ Narayanan/Uribarri Am J Nephrol 2 DOI: 10.1159/000508023 taining strict policies with strong preference for providers and patients to use hospital-approved technology. Performing monthly telehealth visits would not be possible for this patient population without the ability to remotely monitor their treatments to assess the quality of the home therapy delivered and troubleshoot any issues that may arise. To date, over 90% of Mount Sinai's home dialysis patients have had their monthly visits conducted through telehealth without having to come to the unit for any of their needs. In less urban areas not currently affected as much by COVID-19, such as at Baylor Scott and White Healthcare in Temple, Texas, nephrologists are bracing for an onslaught and have preemptively started using telemedicine for the monthly visits with their home dialysis patients while utilizing the benefits of Sharesource to re-motely monitor, adjust, and troubleshoot their patients' dialysis treatments. cache = ./cache/cord-282021-m1lh7mzd.txt txt = ./txt/cord-282021-m1lh7mzd.txt === reduce.pl bib === id = cord-282151-mai4eggf author = Bai, Lu title = Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China date = 2015-12-16 pages = extension = .txt mime = text/plain words = 3752 sentences = 250 flesch = 57 summary = METHODS: During October 26, 2009, and January 23, 2010, adult patients with pneumonia with laboratory-confirmed or clinically suspected A(H1N1) infections were observed for clinical characteristics, high-resolution chest CT scan, and lung function test changes during acute and 3-month convalescent phases. Multivariate Cox regression identified two independent risk factors for death: progressive dyspnea after resolution of fever (relative risk, 5.852; 95% CI, 1.395-24.541; P = .016) and a higher APACHE (Acute Physiology and Chronic Health Evaluation) II score on presentation (relative risk for each point, 1.312; 95% CI, 1.140-1.511; P < .001). 6 Many studies have been published on the clinical manifestations of A(H1N1) pneumonia during the acute phase of illness, [7] [8] [9] [10] [11] [12] [13] [14] [15] but no information has been reported on symptoms and radiographic and lung function changes in convalescence. Information recorded included demographic data, underlying medical conditions, symptoms, signs, laboratory and chest radiograph fi ndings before therapy and during follow-up, and the clinical course, treatment, and adverse events during hospital stay. cache = ./cache/cord-282151-mai4eggf.txt txt = ./txt/cord-282151-mai4eggf.txt === reduce.pl bib === id = cord-282724-zzkqb0u2 author = Moore, Jason H. title = Ideas for how informaticians can get involved with COVID-19 research date = 2020-05-12 pages = extension = .txt mime = text/plain words = 7588 sentences = 315 flesch = 33 summary = Some key considerations and targets of research include: (1) feature engineering, transforming raw data into features (i.e. variables) that ML can better utilize to represent the problem/target outcome, (2) feature selection, applying expert domain knowledge, statistical methods, and/or ML methods to remove 'irrelevant' features from consideration and improve downstream modeling, (3) data harmonization, allowing for the integration of data collected at different sites/institutions, (4) handling different outcomes and related challenges, e.g. binary classification, multi-class, quantitative phenotypes, class imbalance, temporal data, multi-labeled data, censored data, and the use of appropriate evaluation metrics, (5) ML algorithm selection for a given problem can be a challenge in itself, thus strategies to integrate the predictions of multiple machine learners as an ensemble are likely to be important, (6) ML modeling pipeline assembly, including critical considerations such as hyper-parameter optimization, accounting for overfitting, and clinical interpretability of trained models, and (7) considering and accounting for covariates as well as sources of bias in data collection, study design, and application of ML tools in order to avoid drawing conclusions based on spurious correlations. cache = ./cache/cord-282724-zzkqb0u2.txt txt = ./txt/cord-282724-zzkqb0u2.txt === reduce.pl bib === id = cord-282704-qg2o0ug4 author = Li, Xun title = Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China date = 2020-02-25 pages = extension = .txt mime = text/plain words = 2257 sentences = 159 flesch = 60 summary = title: Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China Methods The clinical records, laboratory findings and radiologic assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. All 25 dead patients with COVID-19 tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by use of RT-PCR on samples from there respiratory tract. In the presents study, all the patients were died of respiratory failure, which indicated that the lung is the most common target organ of SARS-CoV-2. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study cache = ./cache/cord-282704-qg2o0ug4.txt txt = ./txt/cord-282704-qg2o0ug4.txt === reduce.pl bib === id = cord-282474-74273qgk author = Roehrig, Stefan title = Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial date = 2020-09-11 pages = extension = .txt mime = text/plain words = 2881 sentences = 190 flesch = 55 summary = title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial OBJECTIVES: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We define ARDS according to the "Berlin" definition integrating the oxygenation index (P/F ratio), the level of Positive End Expiratory Pressure (PEEP), radiological and clinical findings. TRIAL REGISTRATION: The protocol was registered before starting subject recruitment under the title: "Flow controlled ventilation in ARDS associated with COVID-19" in ClinicalTrials.org with the registration number: NCT04399317. Although the severely ill patients will need intubation and invasive ventilation according to ARDS treatment strategies including low tidal volumes and low end-expiratory pressures, not all patients recover their pulmonary function [3, 4] . cache = ./cache/cord-282474-74273qgk.txt txt = ./txt/cord-282474-74273qgk.txt === reduce.pl bib === id = cord-282730-pawasfh4 author = Contreras, Carlo M. title = Telemedicine: Patient-Provider Clinical Engagement During the COVID-19 Pandemic and Beyond date = 2020-05-08 pages = extension = .txt mime = text/plain words = 3568 sentences = 216 flesch = 45 summary = RESULTS: At many institutions, the number of telemedicine visits dramatically increased within days following the institution of novel coronavirus pandemic restrictions on in-person clinical encounters. To minimize interruption of crucial clinical services and the associated revenue, a rapid transition from in-person outpatient visits to telemedicine encounters was implemented by many academic medical centers and adopted by surgery departments throughout the country. The Centers for Medicare and Medicaid Services (CMS) sought to decrease in-person medical visits by issuing a temporary and emergency relaxation of telemedicine rules via the 1135 waiver and the Coronavirus Preparedness and Response Supplemental Appropriations Act. Enacted on March 6, 2020, this act allowed Original Medicare enrollees the same telemedicine benefits that had been extended to Medicare Advantage enrollees in January 2020. In addition, on March 13, 2020 the FCC funded the Rural Health Care Program that aims to make telemedicine services available to geographically remote patients. cache = ./cache/cord-282730-pawasfh4.txt txt = ./txt/cord-282730-pawasfh4.txt === reduce.pl bib === id = cord-282610-zim7nond author = Proal, Amy title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity date = 2018-12-04 pages = extension = .txt mime = text/plain words = 12428 sentences = 723 flesch = 38 summary = title: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity Intracellular pathogens, including many associated with ME/CFS, drive microbiome dysbiosis by directly interfering with human transcription, translation, and DNA repair processes. The gut microbiome can initiate and promote colorectal cancer at all stages of tumorigenesis by acting as an inducer of DNA damage, generating epigenetic changes, regulating cell growth, and modulating host immune responses (80) . If ME/CFS is driven by successive infection, treatments that support or activate the human immune system could improve microbiome health by allowing patients to better target persistent pathogens. Antibodies and/or clonal T cells identified in patients with ME/CFS are likely activated in response to many of these persistent microbiome pathogens. In ME/CFS, the immune response, metabolism, central nervous system, and human gene expression are all linked by the activity of the microbiome and its associated proteins/metabolites. cache = ./cache/cord-282610-zim7nond.txt txt = ./txt/cord-282610-zim7nond.txt === reduce.pl bib === id = cord-282504-m3npy0om author = Kastritis, Efstathios title = Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID‐19 pandemic date = 2020-06-01 pages = extension = .txt mime = text/plain words = 4642 sentences = 217 flesch = 44 summary = Patients with light chain (AL) amyloidosis have an underlying usually low-grade plasma or B-cell malignancy causing their disease, and they receive chemotherapy (Merlini, et al 2018) , thus, being at higher risk for infections (Kristinsson, et al 2012) , including from SARS-CoV-2, and probably at higher risk for severe COVID-19 (Pietrantonio and Garassino 2020) . Treatments for AL amyloidosis have not been developed in the context of multiple randomized studies, thus, we have limited data to propose one therapy over the other or assess the importance of full vs reduced dosing of critical drugs such as bortezomib or For selected patients who have achieved a satisfactory hematologic response (for example CR or VGPR or even PR with organ response), the treating physician may discuss to complete therapy earlier or continue with a less intensive schedule (for example reduce weekly to bi-weekly bortezomib). cache = ./cache/cord-282504-m3npy0om.txt txt = ./txt/cord-282504-m3npy0om.txt === reduce.pl bib === id = cord-283141-dh8j7lyl author = Haskologlu, Sule title = Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency date = 2020-03-11 pages = extension = .txt mime = text/plain words = 2600 sentences = 172 flesch = 47 summary = [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] Since the parental consanguinity rate is high (23.2%) in Turkey, DOCK8 deficiency has an important place among CIDs. Here, we retrospectively evaluated the clinical and immunologic features and treatment modalities of 20 patients with DOCK8 deficiency and follow-up results of hematopoietic stem cell transplant (HSCT) in 11 patients among them as a single-center experience. clinic, DOCK8 deficiency, follow-up, hematopoietic stem cell transplantation, immunological features Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 (DOCK8) deficiency Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency Clinical and immunological correction of DOCK8 deficiency by allogeneic hematopoietic stem cell transplantation following a reduced toxicity conditioning regimen Successful hematopoietic stem cell transplantation after myeloablative conditioning in three patients with dedicator of cytokinesis 8 deficiency (DOCK8) related Hyper IgE syndrome cache = ./cache/cord-283141-dh8j7lyl.txt txt = ./txt/cord-283141-dh8j7lyl.txt === reduce.pl bib === id = cord-282780-34j7gquo author = Lai, Kevin E. title = Tele-Neuro-Ophthalmology During the Age of COVID-19 date = 2020-06-26 pages = extension = .txt mime = text/plain words = 6297 sentences = 292 flesch = 46 summary = In addition, a physician can use phone visits to triage visual symptoms with a normal dilated eye examination by another provider or discuss medication compliance and tolerance, neuroimaging findings, and laboratory test results. Before COVID-19, a telemedicine visit might follow an initial in-person visit: the patient could complete local visual field testing, fundus photographs, OCT, and/or MRI, and then review the results with the neuro-ophthalmologist over phone or video as the case history is discussed. Patients who have Apple iPhone 7 Plus or who do not have an assistant available can use "Vision@home," an online test validated for both near (40 cm) and distance (2 m, assistant needed) visual acuities that is accessible free on their phone browser at www.visionathome.com.au (9) . Conceptually, technological privacy and security refer to how the user (doctor-patient), the company providing the platform (e.g., Zoom and Google), and everyone else on the internet (external parties) relate to each other (see Supplemental Digital Content 15, Figure E8 , http://links.lww. cache = ./cache/cord-282780-34j7gquo.txt txt = ./txt/cord-282780-34j7gquo.txt === reduce.pl bib === id = cord-282963-p04c5nn7 author = Oliveros, Estefania title = Rapid Deterioration of Hospital-Acquired COVID-19 in a Patient on Extracorporeal Left Ventricular Assist Support date = 2020-09-21 pages = extension = .txt mime = text/plain words = 1063 sentences = 74 flesch = 46 summary = DESIGN: : We present a unique case report of hospital-acquired COVID-19 in a patient on temporary mechanical circulatory support. Emphasize the importance of early advanced care planning in patients with heart failure and COVID-19 3. Over the course of 2 hours the patient developed severe hypoxemia with oxygen saturations of 70%, followed by hypotension and low flows through the Centrimag®. While predictors of rapid disease progression have yet to be elucidated, early trends of inflammatory markers may be helpful to risk stratify COVID-19 patients and identify those who are likely to become critically ill (1). Presently broad testing of asymptomatic patients and HCW for COVID-19 is not available but may have impacted disease transmission in this case. It illustrates the high risk for development of COVID-19 for vulnerable hospitalized patients. It illustrates the high risk for development of COVID-19 for vulnerable hospitalized patients. Clinical Pathology of Critical Patients with Novel Coronavirus Pneumonia (COVID-19). cache = ./cache/cord-282963-p04c5nn7.txt txt = ./txt/cord-282963-p04c5nn7.txt === reduce.pl bib === id = cord-282783-ps5jyjkl author = nan title = Full Issue PDF date = 2020-09-30 pages = extension = .txt mime = text/plain words = 15926 sentences = 843 flesch = 41 summary = The Childhood Cancer Survivor Study showed a 10-fold higher risk of pericardial disease in all CCS versus siblings (30year cumulative incidence, 3 .0%) and a dose-response relation with chest RT (11) . The literature on ECG abnormalities in large cohorts of long-term CCS is sparse (46, 47) , Data on the use of ambulatory ECG monitoring to define the prevalence of brady-and tachyarrhythmias induced by cardiotoxic cancer treatments are needed, but must be carefully weighed against the potential patient burden and clinical significance. Interestingly, a prior study in testicular cancer survivors showed that those patients who were exposed to cisplatin-based chemotherapy nearly 3 to more than 20 years ago had a more severe reduction in FMD and higher levels of circulating endothelial cells than those not exposed (13) . cache = ./cache/cord-282783-ps5jyjkl.txt txt = ./txt/cord-282783-ps5jyjkl.txt === reduce.pl bib === id = cord-282956-f7if9e5q author = Yaghi, Shadi title = SARS2-CoV-2 and Stroke in a New York Healthcare System date = 2020-05-26 pages = extension = .txt mime = text/plain words = 2888 sentences = 151 flesch = 40 summary = BACKGROUND AND PURPOSE: With the spread of coronavirus disease 2019 (COVID-19) during the current worldwide pandemic, there is mounting evidence that patients affected by the illness may develop clinically significant coagulopathy with thromboembolic complications including ischemic stroke. METHODS: We conducted a retrospective cohort study of consecutive patients with ischemic stroke who were hospitalized between March 15, 2020, and April 19, 2020, within a major health system in New York, the current global epicenter of the pandemic. In this multi-ethnic study, we report key demographic and clinical characteristics of patients who develop ischemic stroke associated with acute severe acute respiratory syndrome CoV-2 coronavirus infection. The observed rate of imaging-confirmed acute ischemic stroke in hospitalized patients with COVID-19 of 0.9% was lower compared with prior reports from Chinese COVID-19 studies. cache = ./cache/cord-282956-f7if9e5q.txt txt = ./txt/cord-282956-f7if9e5q.txt === reduce.pl bib === id = cord-282867-kbyxdegu author = Shah, Sayed Zulfiqar Ali title = Scaling the Need, Benefits, and Risks Associated with COVID-19 Acute and Postacute Care Rehabilitation: A Review date = 2020-08-26 pages = extension = .txt mime = text/plain words = 4542 sentences = 247 flesch = 39 summary = The main aim of this study is to review and summarize the evidence regarding the supportive role of physical rehabilitation techniques in managing COVID-19-associated pneumonia. In this review, we also emphasize the use of rehabilitation techniques in the management of pneumonia in COVID-19-infected patients. The purpose of this study was to review the evidence regarding the supportive role of treatment options available in physical rehabilitation to manage COVID-19 pneumonia effectively. Evidence strongly supports that many rehabilitation techniques including chest physiotherapy and physical therapy modalities can be of great support to manage COVID-19-associated pneumonia [9, 10] . Common problems identified in COVID-19 patients that could be managed by rehabilitation specialists in the postacute phase include musculoskeletal pain, joint pain, reduced range of motion, muscular weakness, neuropathy and myopathy, pulmonary dysfunction, dysphagia, dyspnea, confusion, and impaired activities of daily living. cache = ./cache/cord-282867-kbyxdegu.txt txt = ./txt/cord-282867-kbyxdegu.txt === reduce.pl bib === id = cord-283165-mdkr9qo0 author = Russell, C.D. title = Diagnosis and features of hospital-acquired pneumonia: a retrospective cohort study date = 2015-12-15 pages = extension = .txt mime = text/plain words = 3885 sentences = 202 flesch = 36 summary = The aim of this study was to retrospectively evaluate the accuracy of the diagnosis of HAP in inpatients on acute internal medicine and general surgical wards receiving intravenous antimicrobials for a clinical diagnosis of HAP made by the patient's team. This was a retrospective observational cohort study of medical and surgical inpatients receiving intravenous antimicrobials for a clinical diagnosis of HAP at a tertiary care hospital in Edinburgh, UK. To be classified as radiologically confirmed HAP in this study, chest X-ray evidence of a new or progressive lung infiltrate was required (reported by a radiologist), consistent with the 2005 ATS/IDSA guidelines. In comparison to community-acquired pneumonia, where the culture-positive rate of sputum samples at our institution has been reported as 30%, a bacterial pathogen was identified from 17 of 35 (48.6%) samples from patients with radiologically confirmed HAP and therefore has greater potential to influence management. cache = ./cache/cord-283165-mdkr9qo0.txt txt = ./txt/cord-283165-mdkr9qo0.txt === reduce.pl bib === id = cord-282912-jegpgqqi author = Pilato, Emanuele title = Mechanical complications of Myocardial Infarction during Covid-19 Pandemic: An Italian single-Centre experience: Heart ruptures in covid-19 era date = 2020-09-18 pages = extension = .txt mime = text/plain words = 1393 sentences = 64 flesch = 44 summary = This phenomenon caused a significant reduction in acute coronary syndrome-related interventional procedures with a subsequent increase in critical hospitalizations and post-infarction mechanical complications. A case series of cardiac ruptures during the COVID-19 lockdown and the surgical treatment of a huge post-ischemic cardiac pseudoaneurysm complicated by a "contained" free wall rupture are presented. Serum analysis and ECG were negative for a new ACS, but the echocardiogram revealed the presence of a huge dilatation of the cardiac apex (6.5 cm x 5.2 cm) complicated by subacute rupture of its posterior wall and by organized thrombosis inside it (figure 1A). All patients were discharged in very good general state but this report, in our opinion, demonstrated and confirmed two key points of the ACS treatment: early coronary revascularization reduces significantly the incidence of the mechanical complication but COVID-19 pandemic could completely thwart these prevention strategies and change the cardiac surgery population that we will have to deal with in the next months [5] . cache = ./cache/cord-282912-jegpgqqi.txt txt = ./txt/cord-282912-jegpgqqi.txt === reduce.pl bib === id = cord-283738-v3h7p297 author = Makar, Michael title = Gastrointestinal Findings in a Patient With COVID-19 date = 2020-06-11 pages = extension = .txt mime = text/plain words = 1428 sentences = 103 flesch = 52 summary = The novel coronavirus (severe acute respiratory syndrome coronavirus 2) that causes coronavirus disease 2019 was discovered in December 2019 in Wuhan, China, and has rapidly spread across the world becoming a pandemic and disrupting societies, economies, and public health. We present a patient diagnosed with coronavirus who presented with several days of GI symptoms and discuss the relevance of GI disease and liver injury in these patients. 9 We present a patient diagnosed with COVID-19 who presented with several days of GI symptoms and discuss the relevance of GI disease and liver injury in these patients. 2 Several studies have reported that patients may initially present with GI symptoms such as diarrhea and nausea a few days before developing pulmonary manifestations. We present a patient with 3 days of nausea, vomiting, and diarrhea before developing fever and acute respiratory distress syndrome from COVID-19. Digestive symptoms in COVID-19 patients with mild disease severity: Clinical presentation, stool viral RNA testing, and outcomes cache = ./cache/cord-283738-v3h7p297.txt txt = ./txt/cord-283738-v3h7p297.txt === reduce.pl bib === id = cord-283513-3f4rsgzm author = Jaywant, Abhishek title = Behavioral interventions in acute COVID-19 recovery: A new opportunity for integrated care date = 2020-07-07 pages = extension = .txt mime = text/plain words = 1265 sentences = 82 flesch = 35 summary = title: Behavioral interventions in acute COVID-19 recovery: A new opportunity for integrated care Here, we describe how neuropsychology and consultation-liaison psychiatry have collaborated to implement interventions within this unit to facilitate patients' recovery. Consistent with early reports [4] , we have found a high prevalence of cognitive dysfunction in COVID-19 patients on our recovery unit. To facilitate orientation and memory, all patient rooms have a large whiteboard on which providers write their names and where patients' rehabilitation goals and progress are recorded. Psychoeducation on rehabilitation; clinician-led mindfulness; virtual reality-based mindfulness; cognitive restructuring; problem-solving; brief psychotherapy scheduled prior to PT/OT; cognitive-behavioral psychotherapy group; chair yoga. Use of room whiteboard to track date, location, names of providers, and rehabilitation goals and progress; clinicians wear large ID tags and assist in reorientation; "memory books." Early intraintensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients cache = ./cache/cord-283513-3f4rsgzm.txt txt = ./txt/cord-283513-3f4rsgzm.txt === reduce.pl bib === id = cord-283215-dgysimh5 author = Al-Jabir, Ahmed title = Impact of the coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation) date = 2020-05-12 pages = extension = .txt mime = text/plain words = 9055 sentences = 492 flesch = 43 summary = Prioritisation of surgical services during this pandemic must be a careful balance of patient needs and resource availability and the European Association of Urology Guidelines Office offer the following suggestions for factors that must be taken into account [3] Whilst there have been no publication of guidelines by any professional association for the management of stone surgery during the COVID-19 pandemic, there have been some guidance published by Proietti et al [48] suggesting telephone triage of patients followed by prioritisation based on stone size and location, the presence of any obstructive uropathy, patient symptoms, presence of any stents or nephrostomy tubes and any other complicating factors such as renal failure or a solitary kidney. With guidelines specific to each specialty being implemented and followed, surgeons should be able to continue to provide safe and effective care to their patients during the COVID-19 pandemic. cache = ./cache/cord-283215-dgysimh5.txt txt = ./txt/cord-283215-dgysimh5.txt === reduce.pl bib === id = cord-283517-7gd0f06m author = Deak, Eszter title = Right-Sizing Technology in the Era of Consumer-Driven Health Care date = 2017-08-01 pages = extension = .txt mime = text/plain words = 6857 sentences = 331 flesch = 45 summary = Today, we have molecular point-ofcare (mPOC) devices that can provide a rapid diagnostic answer within 20 minutes in a clinic, multiplex PCR sample-to-answer devices that can screen for >20 analytes in a single specimen in about an hour, high-volume automation that can enhance throughput and efficiency in the clinical microbiology laboratory with digital imaging, and next-generation sequencing (NGS) that can reveal a treasure trove of information in a single test. Factors may include syndrome-specific diagnostic needs, ease of use, the need for rapid results, improved sensitivity and specificity, operational needs (such as staffing and expertise), laboratory design (such as centralized versus decentralized models), cost, consumer demand, and the potential for improved patient outcomes. Considerations that go into the selection of a test or instrument platform for implementation include perceived turnaround time needs for improved patient care, sample volume requirements, number of tests expected, suitability for the intended laboratory based on available expertise and desired workflow, as well as cost. cache = ./cache/cord-283517-7gd0f06m.txt txt = ./txt/cord-283517-7gd0f06m.txt === reduce.pl bib === id = cord-284163-3jmqzemf author = Seffer, Malin-Theres title = Heparin 2.0: A New Approach to the Infection Crisis date = 2020-07-02 pages = extension = .txt mime = text/plain words = 2982 sentences = 156 flesch = 43 summary = This narrative review will give a brief overview regarding some of the extracorporeal devices that could be used to treat COVID-19 patients, including the Seraph® 100 Microbind® Affinity Blood Filter, produced by ExThera Medical (Martinez, CA, USA), first licensed in the European Economic Area in 2019. Bacteria, viruses, fungi, and toxins have been shown to bind to the immobilized heparin in a similar way to the interaction with heparan sulfate on the cell surface. Of note, it has recently been demonstrated that SARS-CoV-2 attaches to heparin through its surface protein Spike 1 receptor-binding domain [21] . The Seraph ® 100 Microbind ® Affinity Blood Filter is an extracorporeal hemoperfusion device whose functional core, that is, polyethylene beads (diameter of 0.3 mm) with immobilized heparin bound to it, mimics a naturally mammalian cell surface (Fig. 1) . Cytokines in blood from septic patients interact with surface-immobilized heparin cache = ./cache/cord-284163-3jmqzemf.txt txt = ./txt/cord-284163-3jmqzemf.txt === reduce.pl bib === id = cord-283583-pwlbrxn3 author = Zhang, Xiao-Ai title = Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012 date = 2015-01-09 pages = extension = .txt mime = text/plain words = 3779 sentences = 207 flesch = 51 summary = A higher frequency of severe clinical outcome and nervous system manifestation were also observed in the SAFV-positive HFMD patients. A patient was considered to be infected with SAFV when positive detection was obtained in any type of the samples. Genetic characterization of SAFVs. A phylogenetic tree was constructed based on the VP1 nucleotide sequences of Saffold cardiovirus detected in clinical samples of 82 patients in the current study, and sequences downloaded from GenBank by maximum likelihood method using MEGA 6.0 (Figure 1) . Detection of SAFV in sera and CSFs. Additional 171 CSFs were collected from patients with HFMD-associated encephalitis, and six (3.5%) were found to be SAFV-positive using real-time RT-PCR, and five were further confirmed by nested RT-PCR targeting the 59-UTR. In our study, SAFVs were co-detected with other viruses in 14 (82.4%), 9 (75.0%), and 28 (32.6) specimens in ARTI, diarrhea and HFMD patients respectively. cache = ./cache/cord-283583-pwlbrxn3.txt txt = ./txt/cord-283583-pwlbrxn3.txt === reduce.pl bib === id = cord-283779-mudwcypl author = Lauretani, Fulvio title = Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications date = 2020-05-11 pages = extension = .txt mime = text/plain words = 9727 sentences = 500 flesch = 42 summary = The chronic increase in inflammatory cytokines, augmented by COVID-19 infection, may explain the higher tendency for "the cascade leading to pulmonary fibrosis and insufficiency and activation of clotting" and poorer clinical prognosis, especially in multimorbid older persons (4) . In case of persistent fever, higher than 37.5°C for a time longer than 3 days and peripheral oxygen level lower than 95% after starting therapy, we should consider and proceed to hospitalization especially in multimorbid older patients with cardiac, respiratory diseases and diabetes. First, patients at risk for poor outcomes and higher mortality following infection with SARS-CoV-2, namely older adults and multimorbid individuals, should be checked for malnutrition through screening and assessment. Older patients infected by COVID-19 often experience atypical and less severe symptoms in older persons, side-effects of the drugs and require specific nutritional and motor treatment for avoiding disability and death. cache = ./cache/cord-283779-mudwcypl.txt txt = ./txt/cord-283779-mudwcypl.txt === reduce.pl bib === id = cord-283682-4fcyoyea author = Chan, Edward D. title = Mycoplasma pneumoniae-Associated Bronchiolitis Causing Severe Restrictive Lung Disease in Adults Report of Three Cases and Literature Review date = 1999-04-30 pages = extension = .txt mime = text/plain words = 3963 sentences = 256 flesch = 37 summary = title: Mycoplasma pneumoniae-Associated Bronchiolitis Causing Severe Restrictive Lung Disease in Adults Report of Three Cases and Literature Review There were two with respiratory bronchiolitis, one with panbronchiolitis, one patient with bronchiolitis obliterans organizing pneumonia (BOOP), and six with acute inflammatory bronchiolitis. Conclusions In adults, Mycoplasma-associated bronchiolitis without pneumonia is rarely reported, but in hospitalized patients, it may be more common than expected and may be associated with severe physiologic disturbances. In another patient, an acute obstructive defect with hyperinflation, a diffuse and fine granular pattern on chest radiograph, and a cold agglutinin titer of 1:1,024 were found, consistent with constrictive bronchiolitis due to either a viral or Mycoplasma infection. Fraley et al 12 described a patient with respiratory failure from M pneumoniae pneumonia who had both acute necrotizing pneumonitis with consolidation and "bronchiolitis obliterans" on open lung biopsy specimen. cache = ./cache/cord-283682-4fcyoyea.txt txt = ./txt/cord-283682-4fcyoyea.txt === reduce.pl bib === id = cord-283267-72wrzw09 author = Moores, Lisa K. title = Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report date = 2020-06-02 pages = extension = .txt mime = text/plain words = 8241 sentences = 474 flesch = 40 summary = The recognition of the coagulopathy with COVID-19, and the early evidence that suggests that thrombosis in these patients is higher than that seen in similarly ill hospitalized patients with other respiratory infections has led to the urgent need for practical guidance regarding prevention, diagnosis, and treatment of VTE. 19 Pooled risk estimates for benefits and harms of anticoagulant thromboprophylaxis in critically ill medical patients without COVID-19 differ across meta-analyses, 19, 22, 46 but practice guidelines consistently recommend anticoagulant thromboprophylaxis with LMWH (or unfractionated heparin [UFH]) over no such therapy. Our literature search did not identify any randomized trials assessing the efficacy and safety of anticoagulants for the treatment of acute VTE in hospitalized or critically ill COVID-19 patients. Our literature search did not identify any randomized trials or prospective cohort studies assessing the efficacy or safety of any thrombolytic therapies for the management of critically ill patients with COVID-19 without objective evidence of VTE and VTE-associated hypotension. cache = ./cache/cord-283267-72wrzw09.txt txt = ./txt/cord-283267-72wrzw09.txt === reduce.pl bib === id = cord-284038-93s3ffoy author = Keyhanian, Kiandokht title = SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation date = 2020-11-07 pages = extension = .txt mime = text/plain words = 11701 sentences = 592 flesch = 42 summary = Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. Growing number of case reports and/or series indicate that a variety of neurological conditions and post-viral triggered autoimmune complications, as we discuss below, occur in association with SARS-CoV-2 infection which mainly include Guillain-Barré syndromes (GBSs) (table 2), myopathy and rhabdomyolysis (table 2) , encephalopathy, meningoencephalitis, encephalomyelitis, and myelitis (table 3) . Moreover, two cases of acute necrotizing encephalopathy (ANE) in patients with COVID-19 positivity from nasopharyngeal and oropharyngeal swab, but without CSF PCR for SARS-CoV-2 data, were reported in the literature (Poyiadji, Shahin, 2020 , Radmanesh et al. cache = ./cache/cord-284038-93s3ffoy.txt txt = ./txt/cord-284038-93s3ffoy.txt === reduce.pl bib === id = cord-283826-lgyc3sro author = Stiehm, E. Richard title = Therapeutic Use of Immunoglobulins date = 2010-11-05 pages = extension = .txt mime = text/plain words = 9752 sentences = 562 flesch = 37 summary = medical science and thereby placed in the hands of the physician a victorious weapon against illness and death.' ' Since then antibodies in multiple forms (animal and human serums, immune globulins and monoclonal antibodies) have been developed, primarily for prevention of infectious diseases, and less commonly for their treatment. Thus regular use of IVIG in antibody-deficient patients in doses of 400 to 600 mg/kg every 3 to 4 weeks or an equivalent amount given subcutaneously decreases the frequency and severity of otitis and other respiratory tract infections [27, 28] . High-dose IVIG (sufficient to increase the serum IgG levels to 1000 mg/mL) has been used successfully in immunodeficient patients with enteroviral encephalomyelitis [80] [81] [82] [83] . Because IgG represents the major defense of humoral immunity against infection, these patients also require immunoglobulin replacement therapy. Individualizing the dose of intravenous immune serum globulin for therapy of patients with primary humoral immunodeficiency cache = ./cache/cord-283826-lgyc3sro.txt txt = ./txt/cord-283826-lgyc3sro.txt === reduce.pl bib === id = cord-284188-ujdla954 author = Smith, Silas W. title = Virtual Urgent Care Quality and Safety in the Time of Coronavirus date = 2020-10-16 pages = extension = .txt mime = text/plain words = 5905 sentences = 353 flesch = 50 summary = To assess patient and provider data, systems effectiveness, and ability to provide care with and without admission to the ED, 17, 18 we identified the following variables from the cohort records: provider type, patient age, self-assigned gender, visit date, self-assigned race/ethnicity, 19 comorbidities, previous primary care visits (as an indirect marker of regular access to care), VUC return visits, ED referrals and spontaneous ED visits, ED and dispositions, intubations, and deaths following VUC visits. We evaluated and manually reviewed all patients identified for follow-up to assess outcomes including ED referral during follow-up screening call, hospital admission and course, presence or absence of ED referral on index VUC visit, mortality, and interval metrics. 17 While no direct comparators existed during the pandemic, when decision thresholds to present to the ED were multifactorial, to provide context for departments managing patients as outpatients, we evaluated similar outcomes of patients presenting for ED care who were discharged (not admitted) during the same time period. cache = ./cache/cord-284188-ujdla954.txt txt = ./txt/cord-284188-ujdla954.txt === reduce.pl bib === id = cord-283719-zmizyx7e author = Cheng, Yuan-Yang title = Rehabilitation Programs for Patients with COronaVIrus Disease 2019: Consensus Statements of Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation date = 2020-08-17 pages = extension = .txt mime = text/plain words = 2815 sentences = 175 flesch = 40 summary = An online consensus meeting of an expert panel comprising members of the Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation was held to provide recommendations for rehabilitation protocols in each of the five COVID-19 stages, namely (1) outpatients with mild disease and no risk factors, (2) outpatients with mild disease and epidemiological risk factors, (3) hospitalized patients with moderate to severe disease, (4) ventilator-supported patients with clear cognitive function, and (5) ventilator-supported patients with impaired cognitive function. For patients with advanced disease severity, a well-designed rehabilitation program is even more crucial to improve pulmonary secretion clearance, ameliorates side-effects related to a prolonged bedridden state, and even prevents intensive care unit-acquired weakness. 8 Altogether, potentially significant risk factors for severe COVID-19 that should be identified and considered when designing rehabilitation programs include old age, male gender, hypertension, diabetes, respiratory disease, and CVD. 29 Chest physiotherapy strategies that promote airway clearance include the following: Another important issue in the rehabilitation of patients with moderate to severe disease is preventing deconditioning due to acute illness. cache = ./cache/cord-283719-zmizyx7e.txt txt = ./txt/cord-283719-zmizyx7e.txt === reduce.pl bib === id = cord-283806-a6exd6dn author = Menardi, Endrj title = Telemedicine during COVID‐19 pandemic date = 2020-05-30 pages = extension = .txt mime = text/plain words = 683 sentences = 31 flesch = 40 summary = From 2017 the home monitoring outpatient follow‐up service has been systematically organized mainly for the peculiar geographical features (typically mountainous, vast and with few roads) of the territory served by our hospital, making difficult for patients the access to the health care facilities. From 2017 the home monitoring outpatient follow-up service has been systematically organized mainly for the peculiar geographical features (typically mountainous, vast and with few roads) of the territory served by our hospital, making difficult for patients the access to the health care facilities. We have 454 patients (373 pts -ICDs/Cardiac resynchronization therapy defibrillators (CRT-Ds), 11 pts -PMs/Cardiac resynchronization therapy pacemaker (CRT-P) and 70 pts -ILRs) followed with home monitoring systems, with automatic and periodical transmissions regarding device setting, clinical features and alarms. cache = ./cache/cord-283806-a6exd6dn.txt txt = ./txt/cord-283806-a6exd6dn.txt === reduce.pl bib === id = cord-284042-awl5bb0j author = Carrascosa, J.M. title = Cutaneous Manifestations in the Context of SARS-CoV-2 Infection (COVID-19)() date = 2020-10-15 pages = extension = .txt mime = text/plain words = 3952 sentences = 216 flesch = 45 summary = From the pathogenic point of view, the immune response triggered by infection with SARS-CoV-2 may result in harmful effects, such as endothelial cell dysfunction and activation of J o u r n a l P r e -p r o o f coagulation pathways; this may explain the cardiovascular and thrombotic complications that affect a subgroup of patients. 19 Vesicular lesions, usually monomorphic, appear early on and may at times precede other symptoms (in 15% of patients), 11 although in most cases, up to 79.2% in a series of 24 patents reported by Fernandez-Nieto et al., 20 they occur at the onset of other symptoms. 21 reported the case of a female patient who developed an urticarial rash, accompanied by odynophagia and arthralgia, before developing the full clinical manifestations of COVID-19. cache = ./cache/cord-284042-awl5bb0j.txt txt = ./txt/cord-284042-awl5bb0j.txt === reduce.pl bib === id = cord-283231-ju71zm7w author = Yu, Juan title = RE: Respiratory Infectious Disease in Resource Limited Setting: Radiology Management Advice date = 2020-04-15 pages = extension = .txt mime = text/plain words = 558 sentences = 40 flesch = 56 summary = title: RE: Respiratory Infectious Disease in Resource Limited Setting: Radiology Management Advice Dear Dr. Joob, Dr. Wiwanitkit, and Editors-In many countries and regions where access to health care is limited, it is important for medical institutions to develop appropriate programmes to prevent and control respiratory infections. Special examination rooms and passageways should be reserved for suspected patients. If there is no special examination room for suspected patients, try to divide the time period for the ordinary patients and suspected patients. The use of mobile X-ray machines is also a good option in emergency departments, intensive care units, and isolation rooms. It is best to use a special examination room, if not, the method of inspection by time interval is adopted (1,2). (5) Layout of radiology department: The examination room and operation room that directly contact with patients are contaminated areas, and there should be a buffer zone between contaminated areas and cleaning areas. cache = ./cache/cord-283231-ju71zm7w.txt txt = ./txt/cord-283231-ju71zm7w.txt === reduce.pl bib === id = cord-284365-g46myqe7 author = Guo, Qian title = Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study date = 2020-05-19 pages = extension = .txt mime = text/plain words = 4758 sentences = 229 flesch = 47 summary = Using a mixed-method triangulation design (QUAN + QUAL), this study investigated and compared the mental status and inflammatory markers of 103 patients who, while hospitalized with mild symptoms, tested positive with COVID-19 and 103 matched controls that were COVID-19 negative. Results revealed that COVID-19 patients, when compared to non-COVID controls, manifested higher levels of depression (P < 0.001), anxiety (P < 0.001), and post-traumatic stress symptoms (P < 0.001). The Patient Health Questionnaire, 9-item version (PHQ-9) (Kroenke et al., 2001) , Generalized Anxiety Disorder Assessment 7-item version (GAD-7), Perceived Stress Scale, 10-item version (PSS-10) (Barbosa-Leiker et al., 2013a) , and the PTSD Checklist for DSM-5 (PCL-5) were used to assess the levels of psychological distress of all participants (Wortmann et al., 2016) . Compared with normal controls, patients with COVID-19 presented higher levels of depression, anxiety, and post-traumatic stress symptoms. cache = ./cache/cord-284365-g46myqe7.txt txt = ./txt/cord-284365-g46myqe7.txt === reduce.pl bib === id = cord-284387-cjziykrz author = Garcia-Castrillo, Luis title = European Society For Emergency Medicine position paper on emergency medical systems’ response to COVID-19 date = 2020-05-04 pages = extension = .txt mime = text/plain words = 2346 sentences = 125 flesch = 44 summary = Second, protective measures by health services, especially in public and open environments like emergency departments (EDs) where isolation of potentially infected patients is a real challenge or clinical wards is vital [10] . Clinical care of suspected patients with COVID-19 should focus on early recognition, and immediate isolation, as well as appropriate infection prevention measures and control measures with care taken to optimise supportive care. (1) An informative, coordinated campaign for public and healthcare professionals, focused on mechanisms of contagion [4] , personal protection equipment (PPE) use, and a clinical pathway for the suspected patients infected with COVID-19. (5) The development and implementation of cleaning protocols, considering that coronavirus has been isolated on inanimate objects, and healthcare workers were infected by SARS, even without direct contact with sick patients [15] . The patient, relative or general practitioner may alert the emergency number indicating that a potential case of SARS-CoV-2 infection with severe symptoms is seeking care. cache = ./cache/cord-284387-cjziykrz.txt txt = ./txt/cord-284387-cjziykrz.txt === reduce.pl bib === id = cord-284298-tcied4l5 author = Ojeahere, Margaret Isioma title = Management of psychiatric conditions and delirium during the COVID-19 pandemic across continents: The lessons thus far date = 2020-09-19 pages = extension = .txt mime = text/plain words = 6816 sentences = 351 flesch = 40 summary = In the present study, twenty one early career psychiatrists (9 females and 12 males) from thirteen countries, comprising at least one from five of the seven continents (Africa, Asia, Europe, North J o u r n a l P r e -p r o o f America and South America) were approached without coercion by the lead (MIO) and co-lead (RdF) authors via WhatsApp and emails to share insights and experiences about the challenges and good practices faced in the management of delirium and other psychiatric conditions manifesting in patients with COVID-19 and during the COVID-19 era. Finally, the mental health sector should use the lessons from this pandemic to develop protocols and guidelines for the management of psychiatric conditions in periods of infectious disease outbreaks to increase their level of preparedness globally (Table 4) . cache = ./cache/cord-284298-tcied4l5.txt txt = ./txt/cord-284298-tcied4l5.txt === reduce.pl bib === id = cord-283969-wqrzaxsu author = Antonucci, Michele title = The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis date = 2020-10-28 pages = extension = .txt mime = text/plain words = 2927 sentences = 157 flesch = 44 summary = title: The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis Introduction and objectives We aimed to evaluate how the corona virus disease of 2019 (COVID-19) outbreak influenced emergency department (ED) admissions for urolithiasis, hospitalizations and clinical management of the hospitalized Patients. 3 Urolithiasis represents a frequent cause of ED admissions, accounting for 1%---2% of emergency visits 4 : in a report from a large series of patients admitted to ED in a big Italian hospital, 16% of patients with non-traumatic abdominal pain had a diagnosis of renal or ureteral stone. We performed a multicentric retrospective analysis of ED admissions for urolithiasis in three high volume urology department (>100 surgical procedures for stone disease per year) in Rome -Italy between March and April 2020 and in the same period of 2019. cache = ./cache/cord-283969-wqrzaxsu.txt txt = ./txt/cord-283969-wqrzaxsu.txt === reduce.pl bib === id = cord-284454-malfatni author = McCall, W. Travis title = Caring for Patients From a School Shooting: A Qualitative Case Series in Emergency Nursing date = 2020-08-19 pages = extension = .txt mime = text/plain words = 5449 sentences = 283 flesch = 48 summary = [5] [6] [7] [8] Therefore, providing care to patients who are injured during school-associated shooting events is likely to be particularly stressful for emergency nurses. The purpose of this study was to learn how emergency nurses describe their experiences to identify themes and findings that may translate to practices for improving the mental health and wellness of emergency nurses who care for patients from a multicasualty, school-associated shooting incident. Another participant predicted that community or critical access emergency departments receiving patients from a multicasualty school shooting event may experience even greater emotional challenges because these departments are more likely to have staff who may personally know the victims or their families. Learning from emergency nurses who care for patients from a multicasualty, school-associated shooting event may promote personal and departmental preparedness and improve coping and recovery among the involved clinicians. cache = ./cache/cord-284454-malfatni.txt txt = ./txt/cord-284454-malfatni.txt === reduce.pl bib === id = cord-284545-vn60yd46 author = Sanyaolu, Adekunle title = Comorbidity and its Impact on Patients with COVID-19 date = 2020-06-25 pages = extension = .txt mime = text/plain words = 3742 sentences = 182 flesch = 49 summary = Furthermore, older patients, especially those 65 years old and above who have comorbidities and are infected, have an increased admission rate into the intensive care unit (ICU) and mortality from the COVID-19 disease. This article is part of the Topical Collection on Covid-19 * Adekunle Sanyaolu sanyakunle@hotmail.com 1 Federal Ministry of Health, Abuja, Nigeria A retrospective study of middle-aged and elderly patients with COVID-19 found that the elderly population is more susceptible to this illness and is more likely to be admitted to the ICU with a higher mortality rate [3] . Authorities speculate that subjects with comorbidities were linked to a more severe disease outcome when infected with the novel coronavirus when compared with patients with no underlying disease [31] . Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China cache = ./cache/cord-284545-vn60yd46.txt txt = ./txt/cord-284545-vn60yd46.txt === reduce.pl bib === id = cord-284175-5rre1kbn author = Elsaid, Ossama title = Ventricular Fibrillation Storm in Coronavirus 2019 date = 2020-08-29 pages = extension = .txt mime = text/plain words = 1089 sentences = 87 flesch = 37 summary = Herein, we describe the clinical course of an otherwise healthy patient who experienced persistent ventricular tachycardia and fibrillation which is believed to be directly related to inflammation, as opposed to acute myocardial injury or medications that can prolong the QT interval. One study reported ventricular tachycardia (VT)/VF in 5.9% (11/187) of COVID-19 patients (Table 2 3-9 ), with elevated troponin-T increasing risk, suggesting that myocardial injury precipitates arrhythmia 2 . Tocilizumab was shown to have a robust shortening of the QTc prolongation induced by abundant inflammatory cytokines in patients with acute rheumatoid arthritis 16 . As such, this report suggests that the hyper-inflammatory state in COVID-19 patients can induce ventricular arrhythmias, which may cease abruptly following a reduction in inflammation, in our case from convalescent serum and/or hydrocortisone therapy. QT interval prolongation and torsade de pointes in patients with COVID-19 treated with hydroxychloroquine/azithromycin cache = ./cache/cord-284175-5rre1kbn.txt txt = ./txt/cord-284175-5rre1kbn.txt === reduce.pl bib === id = cord-284332-p4c1fneh author = Bosma, Karen J. title = Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date = 2012-09-19 pages = extension = .txt mime = text/plain words = 14516 sentences = 721 flesch = 37 summary = [47] Although both of these studies were conducted prior to the 1994 AECC definition, ARDS was strictly defined in the aforementioned studies, including a PaO 2 /FiO 2 ratio <150 or intrapulmonary shunt >20% in patients requiring mechanical ventilation and who had diffuse infiltrates on chest radiograph without clinical evidence of heart failure as pulmonary arterial occlusion pressures were <18 mmHg. Building on the results of these two studies, Sinuff and colleagues [48] developed practice guidelines for prophylactic ketoconazole use, and tested the implementation and efficacy of these guidelines in two ICUs (one control and one active comparator). [119] A phase II study enrolling 98 patients with ALI compared an antioxidant enteral feeding formula containing eicosapentaenoic acid, g-linolenic acid and antioxidant vitamins with placebo, and observed improved oxygenation, reduced pulmonary inflammation, fewer days of mechanical ventilation and fewer non-pulmonary organ failures in the treatment arm, although there was no difference in mortality between this approach and the control group. cache = ./cache/cord-284332-p4c1fneh.txt txt = ./txt/cord-284332-p4c1fneh.txt === reduce.pl bib === id = cord-284526-a5kgo4ct author = Gavriilaki, Eleni title = Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses date = 2020-08-27 pages = extension = .txt mime = text/plain words = 6004 sentences = 319 flesch = 32 summary = Experience from previous coronaviruses has triggered hypotheses on the role of endothelial dysfunction in the pathophysiology of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which are currently being tested in preclinical and clinical studies. Recent evidence suggests that signs and symptoms of severe coronavirus disease-2019 (COVID-19) infection resemble the clinical phenotype of endothelial dysfunction and share mutual pathophysiological mechanisms [1] . Experience from previous coronaviruses has triggered studies testing hypotheses on the role of the endothelial dysfunction in patients with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Α high rate of VTE (43%, mainly PE) overall was reported in another series of 150 ICU patients in which patients with COVID-19associated acute respiratory distress syndrome (ARDS) had higher rates of thrombotic complications compared with non-COVID-19-ARDS [65] . Autoantibodies against human epithelial cells and endothelial cells after severe acute respiratory syndrome (SARS)-associated coronavirus infection cache = ./cache/cord-284526-a5kgo4ct.txt txt = ./txt/cord-284526-a5kgo4ct.txt === reduce.pl bib === id = cord-284983-xvtkso79 author = Vigiola Cruz, Mariana title = Safety and Efficacy of Bedside Peritoneal Dialysis Catheter Placement in the COVID-19 Era: Initial Experience at a New York City Hospital date = 2020-05-26 pages = extension = .txt mime = text/plain words = 3938 sentences = 187 flesch = 39 summary = title: Safety and Efficacy of Bedside Peritoneal Dialysis Catheter Placement in the COVID-19 Era: Initial Experience at a New York City Hospital INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is common in critically ill patients with COVID-19. Unparalleled numbers of patients with AKI and shortage of dialysis machines and operative resources prompted consideration of expanded use of urgent-start peritoneal dialysis (PD) and evaluation of the safety and efficacy of bedside surgical placement of PD catheters. The catheter should be flushed with heparinized saline following each critical step of the procedure to ensure adequate Insertion of the catheters in surgical clinic for ambulatory patients with CKD mimics the ICU bedside technique, with slight modifications. In our limited series, bedside placement of peritoneal dialysis catheters in the early phases of the COVID-19 pandemic offered a safe and effective option for establishment of access for renal replacement therapy. cache = ./cache/cord-284983-xvtkso79.txt txt = ./txt/cord-284983-xvtkso79.txt === reduce.pl bib === id = cord-284251-brn5izwo author = Melmed, Kara R. title = Risk factors for intracerebral hemorrhage in patients with COVID-19 date = 2020-09-24 pages = extension = .txt mime = text/plain words = 3640 sentences = 189 flesch = 41 summary = We performed a retrospective cohort study of adult (age ≥ 18 years) patients admitted to the NYU Langone Health System (NYU Langone Medical Center, NYU Brooklyn, NYU Winthrop, or NYU Langone Orthopedic Hospital) who had both a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) test result and neuroimaging performed between March 1 and April 27, 2020. We used binary logistic regression models to estimate the odds ratios and 95% confidence intervals (OR, 95% CI) of therapeutic anticoagulation use and ICH in patients hospitalized with COVID-19 adjusting for previously identified factors associated with ICH (age, gender, ethnicity, hypertension, systolic blood pressure) and might plausibly be associated with ICH in COVID-19 patients. Binary logistic regression models were used to assess for mortality in both ICH and non-ICH patients adjusting for previously reported risk factors, age [7] and maximum hospital SOFA score, [18] as a marker for disease severity. cache = ./cache/cord-284251-brn5izwo.txt txt = ./txt/cord-284251-brn5izwo.txt === reduce.pl bib === id = cord-285354-bp2dozzg author = Costanzi, Andrea title = In response to: Surgery in the COVID-19 phase 2 Italian scenario: Lessons learned in Northern Italy spoke hospitals date = 2020-07-01 pages = extension = .txt mime = text/plain words = 1312 sentences = 77 flesch = 55 summary = 1097 W e read with interest the article "COVID-19 outbreak in Northern Italy: Viewpoint of the Milan area surgical community," which reported the pandemic surge response of our colleagues within tertiary hospitals in Lombardy. As surgeons operating in spoke hospitals, we have paved through the pandemic in an unusual and unexpected way, many of us having to turn from surgical specialists into coronavirus disease (COVID) ward doctors. Nonetheless, being a surgeon used to emergencies in peripheral hospitals was a valuable resource during the COVID mass casualty incident because of our commitment to patients and acute care background. 1 Our daily schedule changed dramatically when we were asked to cancel elective surgery to increase the hospital capacity in mechanical respirators and intensive care personnel for COVID-19 patients. Surgery in the coronavirus disease 2019 phase 2 Italian scenario:Lessons learned in northern Italy spoke hospitals W e thank Dr. Costanzi and colleagues for their appreciation and interesting insights about our work. cache = ./cache/cord-285354-bp2dozzg.txt txt = ./txt/cord-285354-bp2dozzg.txt === reduce.pl bib === id = cord-285469-b61y9ezi author = Hernández-Fernández, Francisco title = Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description date = 2020-07-09 pages = extension = .txt mime = text/plain words = 7007 sentences = 368 flesch = 42 summary = The aim of our study is to describe the clinical characteristics, laboratory findings, neuroimaging and available pathological anatomy data, as well as the presentation, therapeutic management and clinical outcomes of patients with acute CVD in a healthcare setting with a high incidence of transmission of this virus. We registered all hospitalized patients with COVID-19 reported during this period, and included all patients diagnosed with acute CVD, both ischaemic and haemorrhagic, treated consecutively by neurology, neurosurgery and the intensive care unit. Bivariates studies were designed to contrast the main variables among CVD patients, between ischaemic/haemorrhagic subtypes within the COVID-19 group, and to assess clinical prognosis. The other three haemorrhagic cases were detected on varying days of clinical evolution because having been intubated, sedated and treated for SARS-CoV-2 infection, the neurological manifestations were masked prior to tracheal extubation, when difficulty arousing these patients was observed. cache = ./cache/cord-285469-b61y9ezi.txt txt = ./txt/cord-285469-b61y9ezi.txt === reduce.pl bib === id = cord-285472-cj5r3xt1 author = Kaur, Parminder title = Acute upper limb ischemia in a patient with COVID-19 date = 2020-05-13 pages = extension = .txt mime = text/plain words = 1113 sentences = 59 flesch = 42 summary = Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with upper and lower respiratory tract symptoms, with complications related to cytokine storm syndrome and acute respiratory distress syndrome. As per American Society of Hematology, some patients with severe coronavirus disease 2019 (COVID-19) have fulminant activation of coagulation and consumption of coagulation factors, which meets the criteria for disseminated intravascular coagulation as per International Society on Thrombosis and Haemostasis. Thus, complement inhibition may be a reasonable treatment for COVID-19-related systemic thrombosis by reducing the innate immune-mediated consequences of severe coronavirus infection [10] . In conclusion, we report a COVID-19 patient who developed arterial thrombosis leading to acute ischemia in the right upper extremity. Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia cache = ./cache/cord-285472-cj5r3xt1.txt txt = ./txt/cord-285472-cj5r3xt1.txt === reduce.pl bib === id = cord-285360-svczr721 author = Ganesh, Aravind title = Ignorance is not bliss: managing uncertainty in acute stroke treatment in the COVID-19 era date = 2020-10-31 pages = extension = .txt mime = text/plain words = 1608 sentences = 68 flesch = 34 summary = Treatment delays may seem inevitable with competing priorities like donning/doffing PPE, greater attention to the patient's respiratory status with more frequent pre-emptive intubation, and a Fig. 1 During typical emergency medical scenarios like ischemic stroke, there are various factors that are immediately available ("known") at the time of decision-making for physicians, patients, and their caregivers/ proxies, whereas other factors are potentially knowable but lost to an "information bottleneck" and still others lie hidden behind a "knowledge barrier" (a). The COVID-19 pandemic has resulted in a constellation of systemic and workflow changes that have resulted in additional unique challenges in information flow for emergency medical decision-making (b). Nevertheless, by appreciating the underlying pitfalls in information flow, we can adopt a more proactive and nuanced approach to emergency decision-making and potentially mitigate the impact of COVID-19 on patient care (Fig. 1d) . cache = ./cache/cord-285360-svczr721.txt txt = ./txt/cord-285360-svczr721.txt === reduce.pl bib === id = cord-284979-lyt98od1 author = Sia, Charmaine Si Min title = Critical Coronavirus Disease 2019 in a Hemodialysis Patient: A Proposed Clinical Management Strategy date = 2020-07-30 pages = extension = .txt mime = text/plain words = 2859 sentences = 161 flesch = 43 summary = We report our experience in treating the first case of COVID-19 in a HD patient in Singapore who had a severe clinical course including acute respiratory distress syndrome and propose a clinical management strategy. We also highlight the importance of early recognition and intervention for disease control, dialysis support in an acute hospital isolation facility, deisolation protocol, and discharge planning due to prolonged viral shedding. A case series of an outbreak in a dialysis center in Wuhan, where HD patients were observed to have a milder disease course or total absence of symptoms with lower levels of serum inflammatory cytokines, suggested that this is due to the inability to mount an effective cellular immune response and hence an absence of cytokine release syndrome [3] . We examined international guidelines provided by different centers [14] and proposed a workflow based on the time points of the clinical course of COVID-19 disease in ESKD patients (Fig. 3) . cache = ./cache/cord-284979-lyt98od1.txt txt = ./txt/cord-284979-lyt98od1.txt === reduce.pl bib === id = cord-284995-8lyr3gs4 author = Fiorina, Laurent title = COVID-19 et troubles du rythme date = 2020-10-02 pages = extension = .txt mime = text/plain words = 1416 sentences = 147 flesch = 59 summary = Les connaissances dans ce domaine sont encore loin d'être exhaustives mais plusieurs séries publiées concernant les patients atteints de la COVID-19 retrouvent une proportion significative de troubles du rythme, dont certains pouvant potentiellement mener à une issue fatale. Sur une série de 146 patients hospitalisés pour la COVID-19, 20% avaient une atteinte myocardique (définie comme une élévation significative de troponine I, avec des signes électrocardiographiques (ECG) compatibles avec une ischémie myocardique) résultant en une J o u r n a l P r e -p r o o f mortalité de 51.2% comparée à 4.5% chez les patients sans atteinte myocardique [2] . Troubles du rythme observés à la phase aigüe : Description -Les palpitations étaient un symptôme de présentation initial de la maladie chez 7.3% des patients hospitalisés pour la COVID-19 dans une série de Wuhan en Chine [7] . cache = ./cache/cord-284995-8lyr3gs4.txt txt = ./txt/cord-284995-8lyr3gs4.txt === reduce.pl bib === id = cord-284576-nemh4wdo author = Sims, Jonathan T. title = Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19 date = 2020-09-10 pages = extension = .txt mime = text/plain words = 1643 sentences = 91 flesch = 42 summary = Methods Blood samples from adult patients hospitalized with COVID-19 were analyzed using high-throughput and ultrasensitive proteomic platforms and compared with ageand sex-matched healthy controls to provide insights into differential regulation of 185 markers. Objective: To identify and characterize the host inflammatory response to SARS-CoV-2 59 infection, we assessed levels of proteins related to immune responses and cardiovascular 60 disease, in patients stratified as mild, moderate, and severe, versus matched healthy controls. Objective: To identify and characterize the host inflammatory response to SARS-CoV-2 59 infection, we assessed levels of proteins related to immune responses and cardiovascular 60 disease, in patients stratified as mild, moderate, and severe, versus matched healthy controls. Furthermore, in a limited series of patients who were sampled 69 frequently confirming reliability and reproducibility of our assays, we demonstrate that 70 intervention with baricitinib attenuates these circulating biomarkers associated with the cytokine 71 The COVID-19 pandemic created an overwhelming need to define host-derived molecular 96 mediators of disease severity evident in hospitalized patients. cache = ./cache/cord-284576-nemh4wdo.txt txt = ./txt/cord-284576-nemh4wdo.txt === reduce.pl bib === id = cord-285897-ahysay2l author = Wu, Guangyao title = Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study date = 2020-07-02 pages = extension = .txt mime = text/plain words = 3803 sentences = 178 flesch = 42 summary = OBJECTIVE: To develop and validate machine-learning model based on clinical features for severity risk assessment and triage for COVID-19 patients at hospital admission. CONCLUSION: The machine-learning model, nomogram, and online-calculator might be useful to access the onset of severe and critical illness among COVID-19 patients and triage at hospital admission. Therefore, our objective is to develop and validate a prognostic machine-learning model based on clinical, laboratory, and radiological variables of COVID-19 patients at hospital admission for severity risk assessment during hospitalization, and compare the performance with that of PSI as a representative clinical assessment method. This international multicenter study analyzed individually and in combination, clinical, laboratory and radiological characteristics for COVID-19 patients at hospital admission, to retrospectively develop and prospectively validate a prognostic model and tool to assess the severity of the illness, and its progression, and to compare these with PSI scoring. cache = ./cache/cord-285897-ahysay2l.txt txt = ./txt/cord-285897-ahysay2l.txt === reduce.pl bib === id = cord-284804-6i5zbmm1 author = Pan, Feng title = Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study date = 2020-05-18 pages = extension = .txt mime = text/plain words = 4632 sentences = 254 flesch = 52 summary = Methods: In this case-control study, patients with severe COVID-19 in this newly established isolation center on admission between 27 January 2020 to 19 March 2020 were divided to discharge group and death event group. In the course, persistently lower lymphocyte with higher levels of CRP, PCT, IL-6, neutrophil, LDH, D-dimer, cardiac troponin I (cTnI), brain natriuretic peptide (BNP), and increased CD4+/CD8+ T-lymphocyte ratio and were observed in death events group, while these parameters stayed stable or improved in discharge group. The bivariate and multivariate logistic regressions were used to investigate the risk factors for death events involving the stratified clinical, radiographic, and laboratory parameters with significant differences between two groups on admission, and the odds ratio (OR) with 95% confidence interval (95%CI) were calculated. Besides, more abnormities of biochemical and hematological parameters were observed in death event group compared with discharge group, such as neutrophil, lymphocyte, CRP, PCT, LDH, D-dimer, cTnI, and BNP ( Table 2) . cache = ./cache/cord-284804-6i5zbmm1.txt txt = ./txt/cord-284804-6i5zbmm1.txt === reduce.pl bib === id = cord-285291-pep4opiq author = Remy, Kenneth E. title = Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists* date = 2020-04-29 pages = extension = .txt mime = text/plain words = 7168 sentences = 423 flesch = 41 summary = T he worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has already resulted in critical care demands overwhelming resources in nations such as Italy (1) . Prone positioning for at least 12 hours daily in adults with severe ARDS may increase ventilator-free days, reduce in-hospital mortality, and reduce the need for rescue therapies like inhaled nitric oxide and extracorporeal membrane oxygenation (ECMO) (16, (65) (66) (67) (68) . Nonpharmacologic approaches to these modifiable risk factors include frequent environmental reorientation, cognitive stimulation, minimizing sleep interruptions, engaging familiar visitors, limiting use of sedative medications, and scheduled sedation "holidays." These strategies have consistently shown improved clinical outcomes in critically ill patients and are now considered standard of care (117) . EPVent-2 Study Group: Effect of titrating positive end-expiratory pressure (PEEP) with an esophageal pressure-guided strategy vs an empirical high PEEP-FIO 2 strategy on death and days free from mechanical ventilation among patients with acute respiratory distress syndrome: A randomized clinical trial cache = ./cache/cord-285291-pep4opiq.txt txt = ./txt/cord-285291-pep4opiq.txt === reduce.pl bib === id = cord-284944-hcgfe9wv author = Silvin, Aymeric title = Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19 date = 2020-08-05 pages = extension = .txt mime = text/plain words = 10781 sentences = 503 flesch = 46 summary = Thus, we performed high dimensional flow cytometry and single cell RNA sequencing of COVID-19 patient peripheral blood cells and detected the disappearance of non-classical CD14LowCD16High monocytes, the accumulation of HLA-DRLow classical monocytes, and the release of massive amounts of calprotectin (S100A8/S100A9) in severe cases. Validating these discovery experiments, we performed mass cytometry analysis of an independent cohort of 12 patients (four in each group; control, mild and severe) ( Table S5) , which showed a lower fraction of CD14 Low CD16 High non-classical monocytes in severe compared to mild patients ( Figure 3F and 3G ). This study presents evidence that patients who develop a severe COVID-19 exhibit high levels of calprotectin and inflammatory cytokines and chemokines correlating with an emergency myelopoiesis generating ROS-and NOS-expressing immunosuppressive myeloid cells (HLA-DR Low monocytes and immature subsets of neutrophils). cache = ./cache/cord-284944-hcgfe9wv.txt txt = ./txt/cord-284944-hcgfe9wv.txt === reduce.pl bib === id = cord-285818-eh12luma author = Louis, Shreya title = Continuous Electroencephalography Characteristics and Acute Symptomatic Seizures in COVID-19 Patients date = 2020-08-26 pages = extension = .txt mime = text/plain words = 3429 sentences = 217 flesch = 53 summary = Objective As concerns regarding neurological manifestations in COVID-19 (coronavirus disease 2019) patients increase, limited data exists on continuous electroencephalography (cEEG) findings in these patients. This high percentage of epileptiform abnormalities (EAs) in a specific brain region in COVID-19 patients behooves the question if this is a potential epileptic effect from the SARS-CoV-2 infection or if this is a limitation with the EEG requisition method itself; since patients did not receive the minimum required 21-electrode clinical EEG recommended by American Clinical Neurophysiological Society ACNS) (Sinha et al. Whilte the main goal of this study was to report cEEG findings in a cohort of critically ill COVID-19 patients, the putative associations between survival, clinical outcomes (discharge disposition), cohort characteristics (e.g. comorbidities, age, gender) and EEG findings were also explored. As such, the two COVID-19 patients with clinical acute symptomatic seizures captured on EEG from our cohort are rare findings. cache = ./cache/cord-285818-eh12luma.txt txt = ./txt/cord-285818-eh12luma.txt === reduce.pl bib === id = cord-285467-uxfk6k3c author = Ragni, Enrico title = Management of osteoarthritis during COVID‐19 pandemic date = 2020-05-21 pages = extension = .txt mime = text/plain words = 7077 sentences = 353 flesch = 37 summary = Since an effective immune response against viral infections depends on cytotoxic T cells activation (25) , experimental evidence supports the observation that overexpression of inflammatory cytokines like IL-6 during the viral immune response might be associated with a decreased viral clearance by impairing the polarization and functionality of Th1 and CD8 cells (26), contributing to the worsening of the COVID-19 symptoms, and their management may appear an intriguing therapeutical approach. Overall, the administration of drugs for the control of inflammation, inhibiting the response of the immune system, may be detrimental in the initial phases of the viral infection, reducing the ability of the body to react to the presence of SARS-CoV-2, as observed in patients chronically treated for rheumatoid arthritis (27) . All rights reserved This shall prompt orthopaedics and clinicians in general to evaluate with extreme care the clinical conditions of OA patients not only under the perspective of OA symptoms management but also for undercurrent comorbidities, naturally occurring or OA-treatment-related, that, in the era of COVID-19 pandemic, may strongly affect patients outcomes more than the net combination of SARS-CoV-2 infection and OA. cache = ./cache/cord-285467-uxfk6k3c.txt txt = ./txt/cord-285467-uxfk6k3c.txt === reduce.pl bib === id = cord-285414-vd2d7db2 author = Yu, Qian title = Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients date = 2020-04-27 pages = extension = .txt mime = text/plain words = 3080 sentences = 188 flesch = 48 summary = title: Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients In this study, we aimed to assess the imaging characteristics and risk factors associated with adverse composite endpoints in patients with COVID-19 pneumonia. In this study, we aimed to report the quantitative imaging characteristics and risk factors for adverse composite endpoints, including admission to ICU, acute respiratory failure occurrence, and shock during hospitalization in patients with COVID-19 pneumonia in Jiangsu province, China. In this retrospective, cohort, and AI-assisted study, we reported the imaging risk factors associated with adverse clinical composite endpoints, including admission to ICU, acute respiratory failure, and shock during hospitalization in patients with COVID-19 pneumonia in Jiangsu province, China. Our study of 421 COVID-19 patients suggested an increased pulmonary lesion in bilateral upper lungs were independent risk factors for adverse clinical outcomes, which as far as we know, has not been reported. cache = ./cache/cord-285414-vd2d7db2.txt txt = ./txt/cord-285414-vd2d7db2.txt === reduce.pl bib === id = cord-285755-zblitbo0 author = Zhang, F. title = Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study date = 2020-03-24 pages = extension = .txt mime = text/plain words = 3069 sentences = 164 flesch = 42 summary = [Results] A total of 110 patients with confirmed (n=80) or suspected (n=30) COVID-19 were screened and 48 patients (female 31.3%, mean age 70.58{+/-}13.38 year old) among them with high-sensitivity cardiac troponin I (hs-cTnI) test within 48 hours after admission were included, of whom 17 (17/48, 35.4%) died in hospital while 31 (31/48, 64.6%) were discharged or transferred to other hospital. [Conclusions] Cardiac injury defined by hs-cTnI elevation and elevated d-dimer on admission were risk factors for in-hospital death, while higher SpO2 could be seen as a protective factor, which could help clinicians to identify patients with adverse outcome at the early stage of COVID-19. Short-term prognosis of COVID-19 patients are discrepancy and in-hospital mortality risk are high in severe cases[1] [2] Although previous study had indicated that several risk factors were independently associated with short-term mortality, such as elevated d-dimer, older age and higher Sequential Organ Failure Assessment (SOFA) score [2] , few studies focused on cardiac injury with COVID-19 patients. cache = ./cache/cord-285755-zblitbo0.txt txt = ./txt/cord-285755-zblitbo0.txt === reduce.pl bib === id = cord-284910-vjcrhwqz author = Kirresh, Ali title = COVID-19 infection and high intracoronary thrombus burden date = 2020-07-30 pages = extension = .txt mime = text/plain words = 1773 sentences = 88 flesch = 38 summary = Emerging evidence demonstrates a strong association with a pro-thrombotic state and we present the first patient admitted with COVID-19 and an inferior ST-segment elevation myocardial infarction (STEMI) with evidence of high intracoronary thrombus burden. We review the mechanism of the high thrombus burden, which may be driven by the significant cytokine storm, endothelial dysfunction, increase risk of coronary plaque rupture and hypercoagulability. We present the first patient admitted with inferior ST-segment elevation myocardial infarction (STEMI) with evidence of high intracoronary thrombus burden and provide a review of potential underlying mechanisms. There are emerging theories regarding the mechanism of increased thrombus burden seen in COVID-19, central to which seems to be a significant proinflammatory state (8). Plaque rupture results in an increase in tissue factor (TF), collagen and platelet activation causing increased fibrin production and a higher thrombus burden (16) . cache = ./cache/cord-284910-vjcrhwqz.txt txt = ./txt/cord-284910-vjcrhwqz.txt === reduce.pl bib === id = cord-285226-4ydvjmr3 author = Sekhar, Laligam N. title = The Future of Skull Base Surgery: A View Through Tinted Glasses date = 2020-06-27 pages = extension = .txt mime = text/plain words = 3704 sentences = 224 flesch = 51 summary = This leads to an examination of recent developments in the field and outlines several promising areas of future improvement in skull base surgery, per se, as well as identifying new hospital support systems needed to accommodate these changes. These include, but are not limited to advances in imaging, Raman Spectroscopy and Microscopy, 3-dimensional printing and rapid prototyping, master-slave and semi-autonomous robots, artificial intelligence applications in all areas of medicine, tele-medicine, and green technologies in hospitals. 44 45 More recent technological introductions have proceeded to revolutionize the 46 treatment of challenging skull base pathology including the introduction of 47 endoscopic surgery, advances in neuroimaging, radiosurgery and high energy 48 focused radiotherapy, the perfection of vascular bypasses for replacement of 49 major arteries and venous sinuses involved by tumors 1,2,3 , and the use of skull 50 base approaches to treat complex vascular lesions. Humanoid robotic nursing assistants 558 will be developed and widely used in future due to health care worker shortages, 559 patients' desire to have 24x7 nursing assistance, and the needs created by 560 infectious diseases wherein human-human contact must be minimized. cache = ./cache/cord-285226-4ydvjmr3.txt txt = ./txt/cord-285226-4ydvjmr3.txt === reduce.pl bib === id = cord-285757-fiqx4tll author = Mäkelä, M. J. title = Lack of Induction by Rhinoviruses of Systemic Type I Interferon Production or Enhanced MxA Protein Expression During the Common Cold date = 1999 pages = extension = .txt mime = text/plain words = 1825 sentences = 97 flesch = 50 summary = To study whether MxA protein expression is systemically upregulated during rhinovirus infection, blood specimens were collected from 40 patients with common cold and MxA expression in mononuclear cells analyzed by flow cytometry. In conclusion, expression of MxA in blood lymphocytes and an apparently systemic type I interferon response is not induced during rhinovirus infection or during most other cases of common cold in young adult patients. In the present study, the induction of a systemic IFN response as reflected by the expression of MxA protein in blood lymphocytes of patients with rhinovirus infection was examined. Our data suggests that type I IFN production in serum is not comparable to that seen in most other respiratory viral infections in vivo, since the rhinovirus-positive patients had only low or no expression of the MxA protein and no IFN-a/b was detectable in serum samples. cache = ./cache/cord-285757-fiqx4tll.txt txt = ./txt/cord-285757-fiqx4tll.txt === reduce.pl bib === id = cord-285867-61y4aamj author = Kichloo, Asim title = Atezolizumab-Induced Bell’s Palsy in a Patient With Small Cell Lung Cancer date = 2020-10-13 pages = extension = .txt mime = text/plain words = 1973 sentences = 124 flesch = 43 summary = Neurotoxicity is a rare complication of immune checkpoint inhibitor therapy, and facial palsy as a complication of atezolizumab therapy has only been reported in one additional study. We present the case of a 68-year-old female with a history of small cell carcinoma of the lung presenting with sudden-onset facial palsy and numbness of the distal extremities in the setting of receiving atezolizumab immunotherapy. Clinicians should be aware of this rare adverse effect in order to enact early management including temporary cessation of therapy to prevent morbidity in patients undergoing immunotherapy. 10 Facial palsy secondary to immune checkpoint inhibitor therapy is rare, occurring in only 5 of 364 patients in one retrospective study. Facial palsy is a rare side effect of immune checkpoint inhibitor therapy with atezolizumab. The diagnosis of facial palsy secondary to immune checkpoint inhibitor therapy is one of exclusion, and clinicians should be aware of this as a potential adverse event. cache = ./cache/cord-285867-61y4aamj.txt txt = ./txt/cord-285867-61y4aamj.txt === reduce.pl bib === id = cord-285907-xoiju5ub author = Chang, Shang-Miao title = Comparative study of patients with and without SARS WHO fulfilled the WHO SARS case definition date = 2005-05-31 pages = extension = .txt mime = text/plain words = 3607 sentences = 192 flesch = 59 summary = Abstract To differentiate severe acute respiratory syndrome (SARS) from non-SARS illness, we retrospectively compared 53 patients with probable SARS and 31 patients with non-SARS who were admitted to Mackay Memorial Hospital from April 27 to June 16, 2003. SARS patients with an initially normal chest X-ray study developed infiltrates at a mean of 5 ± 3.44 days after onset of fever (21/22 SARS vs. Severe acute respiratory syndrome (SARS) is a rapidly progressive disease caused by a novel coronavirus. Initial chest X-ray studies were normal in 22 of 53 SARS patients (41%) and 5 of 31 non-SARS patients (16%) ( Table 4 ). All except 1 of the 22 SARS patients with an initially normal chest X-ray study eventually developed abnormalities (mean FD 5 Ϯ 3.44). No non-SARS patient with an initially negative chest X-ray developed abnormalities on follow-up films. cache = ./cache/cord-285907-xoiju5ub.txt txt = ./txt/cord-285907-xoiju5ub.txt === reduce.pl bib === id = cord-286227-foeb0g7u author = Potekaev, Nikolai N. title = Clinical characteristics of dermatologic manifestations of COVID‐19 infection: case series of 15 patients, review of literature, and proposed etiological classification date = 2020-07-03 pages = extension = .txt mime = text/plain words = 1102 sentences = 73 flesch = 46 summary = A 59-year-old male patient presented with fever of 39°C and a rash of the lower extremities in combination with hemorrhagic elements which were consistent with polymorphic cutaneous vasculitis ( Fig. 3a ,b). A 47-year-old female patient with COVID-19 pneumonia developed acral urticarial highly pruritic rash on upper and lower extremities 5 days after the laboratory diagnosis (Fig. 7a, b ). A 71-year-old male patient, 2 weeks prior to our examination, developed papulovesicular eruptions while having escalating clinical symptoms of COVID-19 infection (fever, weakness, cough, shortness of breath) (Fig. 8a,b) . A 46-year-old female patient with confirmed COVID-19 infection and bilateral pneumonia presented with papulovesicular elements in the chest area (Fig. 9) . A 56-year-old male patient with COVID-19 infection presented with skin lesions, also called "bilateral inguinal purple rash." Large pink-red plaques were observed in both inguinal folds with a transition to the inner thighs, with a brownish tint and abundance of follicular papules along the periphery (Fig. 13) . cache = ./cache/cord-286227-foeb0g7u.txt txt = ./txt/cord-286227-foeb0g7u.txt === reduce.pl bib === id = cord-285588-ug7upa3r author = Ajibade, Ayomikun title = Telemedicine in cardiovascular surgery during COVID‐19 pandemic: A systematic review and our experience date = 2020-08-16 pages = extension = .txt mime = text/plain words = 4136 sentences = 196 flesch = 39 summary = [23] [24] [25] TM has already been adapted into primary care, with telephone consultations and home-monitoring systems already are in regular use in general practice, however, with the adjustments made to secondary and tertiary care services in the COVID-19 era, it is unclear as to whether TM can meet the needs of complex specialities such as cardiovascular surgery. 48 While some trials show that superiority of using TM over conventional management may be debatable, the majority of the research indicates that the monitoring of clinical parameters of cardiac patients during COVID-19 is likely to be useful in not only the overall management of the changing health status of patients, but also more specifically in facilitating effective remote presurgical triaging, detecting cardiac deterioration, and managing potential postsurgical complications. Combinations of regular virtual consultations and remote monitoring of clinical parameters are feasible for cardiac surgery patients and would be useful to assess and triage before surgery. cache = ./cache/cord-285588-ug7upa3r.txt txt = ./txt/cord-285588-ug7upa3r.txt === reduce.pl bib === id = cord-286418-9ho5fg3h author = Jenkins, Ian title = Lessons from Walking the Medical Distancing Tightrope date = 2020-05-28 pages = extension = .txt mime = text/plain words = 2625 sentences = 144 flesch = 45 summary = Like many academic programs before the pandemic, UCSD's Division of Hospital Medicine emphasized interdisciplinary bedside rounding, focusing on clinical care, quality, patient experience, and teaching. SARS-CoV2, capable of spreading from presymptomatic and asymptomatic persons, 3 threatened to injure or kill high-risk hospitalized patients (i.e. elderly, or with comorbid illnesses) as well as healthcare workers (HCW), making them patients instead of caregivers during our projected surge. 8 For example, on April 9, UCSD Health had a total census of 471 patients (56% occupancy) of which only 4.2% had COVID, with 10 patients on the hospital medicine service, 8 on ventilators (5.2% of capacity), and only 3 total deaths to date. AAMC guidelines advise that medical students not be involved in patient care unless COVID risks are low and protective equipment and testing are available. 12 As we contemplate the future of hospital care and training, we continue to monitor our distancing efforts for signs of adverse effects on safety, efficiency, and experience. cache = ./cache/cord-286418-9ho5fg3h.txt txt = ./txt/cord-286418-9ho5fg3h.txt === reduce.pl bib === id = cord-286403-gdkwabcj author = Rosovsky, Rachel P. title = Diagnosis and Treatment of Pulmonary Embolism During the COVID-19 Pandemic: A Position Paper from the National PERT Consortium date = 2020-08-27 pages = extension = .txt mime = text/plain words = 2364 sentences = 146 flesch = 40 summary = title: Diagnosis and Treatment of Pulmonary Embolism During the COVID-19 Pandemic: A Position Paper from the National PERT Consortium However, the unique aspects of this virus confound both the diagnosis and treatment of PE, and thus require modification of established algorithms.1-6 Important considerations include adjustment of diagnostic modalities, incorporation of the pro-thrombotic contribution of COVID-19, management of two critical cardio-respiratory illnesses in the same patient, and protecting patients and health care workers while providing optimal care. The National Pulmonary Embolism Response Team (PERT) Consortium, the largest organization in the world specifically dedicated to improving outcomes in PE and advancing the science around this disease, recently published consensus recommendations for the diagnosis, treatment and follow-up for patients with acute PE. Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report cache = ./cache/cord-286403-gdkwabcj.txt txt = ./txt/cord-286403-gdkwabcj.txt === reduce.pl bib === id = cord-285298-r7p44wpe author = Parsonage, William A. title = CSANZ Position Statement on the Evaluation of Patients Presenting With Suspected Acute Coronary Syndromes During the COVID-19 Pandemic # date = 2020-05-21 pages = extension = .txt mime = text/plain words = 2141 sentences = 112 flesch = 45 summary = The position statement complements, and should be read in conjunction with, the National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016: Section 2 'Assessment of Possible Cardiac Chest Pain'. • Early identification of low risk patients who do not require further testing for ischaemia, either by 1) Using a single test of serum troponin level on presentation, or 2) Clinical risk stratification and serial testing of ECG and troponin only • Identification of low risk patients who can safely be discharged from ED with expedited out-patient review and consideration of further testing Whilst these criteria can be used on an individual patient basis, substantial 'system wide' gains are possible using a strategic approach to chest pain assessment [4] . cache = ./cache/cord-285298-r7p44wpe.txt txt = ./txt/cord-285298-r7p44wpe.txt === reduce.pl bib === id = cord-285732-xew5ar1e author = Eperjesiova, Bianka title = Spontaneous Pneumomediastinum/Pneumothorax in Patients With COVID-19 date = 2020-07-03 pages = extension = .txt mime = text/plain words = 799 sentences = 58 flesch = 46 summary = No spontaneous air leak case series have been described in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patient population thus far. We described seven spontaneous air leak cases we found in our coronavirus disease 2019 (COVID-19) positive 976-patient cohort. Air leak in hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients has been sparsely published as case reports, however, the presence of non-invasive ventilation and positive airway pressure were reported prior to this finding [3] [4] . Studies of a severe acute respiratory syndrome with SARS did identify air leak as a frequent complication, often with no relation to intubation or positive pressure ventilation [1] [2] [3] [4] [5] . Of these, we found 20 cases of air leak; three traumatic/post-procedure, 10 post-intubation/mechanical ventilation, and seven spontaneous (five cases of pneumomediastinum and two isolated pneumothorax). One out of seven spontaneous air leak patients expired. Spontaneous pneumomediastinum in patients with severe acute respiratory syndrome cache = ./cache/cord-285732-xew5ar1e.txt txt = ./txt/cord-285732-xew5ar1e.txt === reduce.pl bib === id = cord-286096-h275nner author = Huijskens, Elisabeth G. W. title = Viral and bacterial aetiology of community‐acquired pneumonia in adults date = 2012-08-22 pages = extension = .txt mime = text/plain words = 3714 sentences = 192 flesch = 47 summary = Methods Between April 2008 and April 2009, 408 adult patients (aged between 20 and 94 years) with community‐acquired pneumonia were tested for the presence of respiratory pathogens using bacterial cultures, real‐time PCR for viruses and bacteria, urinary antigen testing for Legionella and Pneumococci and serology for the presence of viral and bacterial pathogens. All samples were tested using real-time PCR for the presence of respiratory viruses and bacteria including adenovirus (AdV), human bocavirus (hBoV), KI-and WU polyomaviruses (KIPyV and WUPyV), human metapneumovirus (hMPV), human rhinovirus (HRV), human coronaviruses (HCoV) (OC43, NL63, HKU and 229E), parainfluenza viruses (PIV), 1-4 influenza viruses A and B (InfA, InfB), respiratory syncytial virus (RSV), Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila psittaci, Chlamydophila pneumoniae, Coxiella burnetii and Streptococcus pneumoniae. This study revealed the viral and bacterial aetiology in 263 (64AE5%) of 408 patients with community-acquired pneumonia. cache = ./cache/cord-286096-h275nner.txt txt = ./txt/cord-286096-h275nner.txt === reduce.pl bib === id = cord-286638-bqxyb61p author = Singh, Awadhesh Kumar title = Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations date = 2020-04-09 pages = extension = .txt mime = text/plain words = 4824 sentences = 281 flesch = 46 summary = The disease burden of coronavirus infectious disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) has been increasing continuously with more than a million confirmed patients and more than 45 thousand deaths globally [1] . Emerging data suggests that COVID-19 is common in patients with diabetes, hypertension, and cardiovascular disease (CVD), although the prevalence rate varied in different studies as well in country-wise data. Evolving data also suggest that patients of COVID-19 with diabetes are more often associated with severe or critical disease varying from 14 to 32% in different studies [15e18, 20, 22, 24] . Though there is limited data about the association of blood glucose levels with disease course in COVID-19 at present, data from other infections like SARS and influenza H1N1 has shown that patients with poor glycemic control have increased risk of complications and death [60, 61] . cache = ./cache/cord-286638-bqxyb61p.txt txt = ./txt/cord-286638-bqxyb61p.txt === reduce.pl bib === id = cord-286525-0354438s author = Lee, Todd C. title = Tocilizumab versus the covid19 tempest: all’s well that ends well or much ado about nothing? date = 2020-09-29 pages = extension = .txt mime = text/plain words = 1440 sentences = 85 flesch = 46 summary = One of the unexpected findings from this study was an observed lack of benefit from steroids in contrast to the RECOVERY randomized controlled trial results [4] or a recent meta-analysis of steroid trials in critically ill patients. The phase III COVACTA trial (NCT04317092) found tocilizumab did not reduce mortality in hospitalized patients with severe COVID-19 pneumonia [11] . Similarly a large trial of sarilumab (NCT04315298) in severe and critical COVID-19 was stopped by the data safety monitoring board due to lack of benefit and a potential signal for harm in non-ventilated patients [12] and a second international trial (NCT04327388) also failed to meet its primary or key secondary outcomes [13] . Reconciling their results with those from randomized control trials raises important questions about the causal effect of the hyperinflammatory response and its role in the development of severe COVID-19. Sanofi provides update on Kevzara® (sarilumab) Phase 3 trial in severe and critically ill COVID-19 patients outside the cache = ./cache/cord-286525-0354438s.txt txt = ./txt/cord-286525-0354438s.txt === reduce.pl bib === id = cord-286477-0euaaspo author = Li, Xiaochen title = Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan date = 2020-04-12 pages = extension = .txt mime = text/plain words = 3243 sentences = 190 flesch = 57 summary = This study aims to describe and compare the 141 epidemiological, demographic, clinical, laboratory and radiological characteristics as well as the 142 complications, treatment and outcomes of hospitalized patients with nonsevere and severe 143 COVID-19. Comparison of findings between nonsevere and severe cases in 223 the patients with positive viral nucleic acid test pre-admission showed essentially the similar 224 differences to that in the total patients (see Table E1 in the Online Repository). In the follow-up period, the complications of COVID-19 were assessed , including acute 297 respiratory distress syndrome (ARDS) (38.3%), cardiac injury (21.7%), liver dysfunction (19.3%), 298 acute kidney injury (17.3%), bacteremia (7.7%), diffuse intravascular coagulation (7.7%), and 299 hyperglycemia (33.2%) ( This study provided a comprehensive data on the epidemiological, demographic, clinical, 338 laboratory, and radiological characteristics as well as the complications, treatment, and outcomes 339 of hospitalized patients with nonsevere and severe COVID-19 in Wuhan. cache = ./cache/cord-286477-0euaaspo.txt txt = ./txt/cord-286477-0euaaspo.txt === reduce.pl bib === id = cord-286574-t9z2ynt5 author = nan title = Speaker presentations date = 2017-09-30 pages = extension = .txt mime = text/plain words = 14833 sentences = 690 flesch = 40 summary = Data on the economic impact of AMR in major pathogens showed that healthcare costs significantly increase in the treatment of infections caused by antibiotic-resistant strains (Maragakis et al. In principle, the major high-level goals consist of optimizing the use of such drugs in health and agriculture and minimizing environmental contamination; sustaining the development of new classes of antimicrobials drugs and other medicines and making them affordable and accessible to all who need them; and much more effective application of infection control and prevention principles. These new agents are bound to change the paradigm for the treatment of infections caused by colistin-resistant Gram-negatives, but uncertainties are still likely to remain, including which agent to use, how to optimize dosing in to maximize efficacy and minimize toxicity as well as potential for development of resistance, and whether use of more than one agent would still be needed. cache = ./cache/cord-286574-t9z2ynt5.txt txt = ./txt/cord-286574-t9z2ynt5.txt === reduce.pl bib === id = cord-286237-x6dr6rsh author = Maes, Bastiaan title = Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial date = 2020-06-03 pages = extension = .txt mime = text/plain words = 11252 sentences = 579 flesch = 49 summary = -mechanical ventilation > 24 h at randomization -clinical frailty scale above 3 -active bacterial or fungal infection -unlikely to survive beyond 48h -neutrophil count below 1500 cells/microliter -platelets below 50.000/microliter -Patients enrolled in another investigational drug study -patients on high dose systemic steroids (> 8 mg methylprednisolone or equivalent for more than 1 month) for COVID-19 unrelated disorder -patients on immunosuppressant or immunomodulatory drugs -patients on current anti-IL1 or anti-IL6 treatment -signs of active tuberculosis -serum transaminase levels >5 times upper limit of normal, unless there are clear signs of cytokine release syndrome defined by LDH >300 IU/L and ferritin >700 ng/ml -history of (non-iatrogenic) bowel perforation or diverticulitis -Pregnant or breastfeeding females (all female subjects deemed of childbearing potential by the investigator must have negative pregnancy test at screening) 5.2.1. cache = ./cache/cord-286237-x6dr6rsh.txt txt = ./txt/cord-286237-x6dr6rsh.txt === reduce.pl bib === id = cord-286683-mettlmhz author = Ortiz-Prado, Esteban title = Clinical, molecular and epidemiological characterization of the SARS-CoV2 virus and the Coronavirus disease 2019 (COVID-19), a comprehensive literature review date = 2020-05-30 pages = extension = .txt mime = text/plain words = 13299 sentences = 726 flesch = 45 summary = Interestingly, the increased amounts of proinflammatory cytokines in serum associated with pulmonary inflammation and extensive lung damage described both in SARS [59] and MERS diseases [60] were also reported in the early study of 41 patients with COVID-19 in Wuhan [41] . A recently published case report of a patient with mild-to-moderate COVID-19 revealed the presence of an increased activated CD4+ T cells and CD8+ T cells, antibody-secreting cells (ASCs), follicular helper T cells (TFH cells), and anti-SARS-CoV-2 IgM and IgG antibodies, suggesting that both cellular and humoral responses are important in containing the virus and inhibiting severe pathology [82] . Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series cache = ./cache/cord-286683-mettlmhz.txt txt = ./txt/cord-286683-mettlmhz.txt === reduce.pl bib === === reduce.pl bib === id = cord-286743-z0e5arlm author = Langer-Gould, Annette title = Early Identification of COVID-19 Cytokine Storm and Treatment with Anakinra or Tocilizumab date = 2020-08-06 pages = extension = .txt mime = text/plain words = 4258 sentences = 213 flesch = 43 summary = Subsequently, a shift in practice by clinicians at some of our medical centers aimed to identify early COVID19-CS through laboratory abnormalities in patients with increasing O2 requirements and to initiate combined treatment with anakinra and corticosteroids occurred. Data were extracted by manual reviewing the EHR, including onset of dyspnea and other COVID-19 symptoms, age, sex, comorbidities, smoking status, tocilizumab and anakinra use, other J o u r n a l P r e -p r o o f treatments rendered for hydroxychloroquine, and/or corticosteroids) , fever (>100.4F), hypotension requiring pressors, dates of admission, intubation, extubation, discharge and/or death. The primary purpose of analyses was to describe clinical outcomes among tocilizumab-or anakinra-treated COVID-19 patients and to examine whether differences in outcomes could be accounted for by COVID19-CS severity and/or duration at the time of treatment initiation (baseline). cache = ./cache/cord-286743-z0e5arlm.txt txt = ./txt/cord-286743-z0e5arlm.txt === reduce.pl bib === id = cord-287048-5od0ssyk author = Areaux, Raymond G. title = Your eye doctor will virtually see you now: synchronous patient-to-provider virtual visits in pediatric tele-ophthalmology date = 2020-08-03 pages = extension = .txt mime = text/plain words = 3046 sentences = 160 flesch = 43 summary = Summary Community transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) in the United States on February 26, 2020, and the rapid spread that followed forced patients, providers, payors, and policy makers to adapt to an unprecedented, nearly instant, and enormous demand for virtual care. The arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, or COVID-19) obliterated these barriers as executive orders forced patients, providers, and payors to adapt to an unprecedented, nearly instant, and enormous demand for virtual care. Regarding the use of synchronous patient-to-provider virtual visits (SPPVV) in pediatric ophthalmology, we have pooled our collective experience at three academic practices across the country to describe initial workflows, technology solutions, use cases, and barriers to care. Regarding the use of synchronous patient-to-provider virtual visits (SPPVV) in pediatric ophthalmology, we have pooled our collective experience at three academic practices across the country to describe initial workflows, technology solutions, use cases, and barriers to care. cache = ./cache/cord-287048-5od0ssyk.txt txt = ./txt/cord-287048-5od0ssyk.txt === reduce.pl bib === id = cord-287102-o19uwryp author = Amit, Moran title = Clinical Course and Outcomes of Severe Covid-19: A National Scale Study date = 2020-07-18 pages = extension = .txt mime = text/plain words = 4182 sentences = 204 flesch = 52 summary = The factors associated with outcomes of critically ill patients with coronavirus disease 2019 (Covid-19) who required treatment in an intensive care unit (ICU) are yet to be determined. The recorded data included the following: age, sex, medical comorbidities (i.e., smoking status, hypertension, diabetes, ischemic heart disease, chronic heart failure, cancer, chronic kidney disease, immunosuppression, cirrhosis, and dementia), medication history, vital signs, chest X-rays, laboratory studies on admission to the ICU, anti-Covid-19 pharmacological therapy in the ICU (antimalarials, antivirals, anti-inflammatories, and plasma from recovered patients), respiratory support method (invasive or noninvasive mechanical ventilation and oxygen mask), renal replacement therapy, nutrition methods (enteral and total parenteral nutrition), the use of extracorporeal membrane oxygenation (ECMO), complications, and outcome. In this nation-based registry study of critically ill patients with Covid-19 who were admitted to ICUs in Israel, the majority of patients were 55 years and older men, and a large proportion required mechanical ventilation. cache = ./cache/cord-287102-o19uwryp.txt txt = ./txt/cord-287102-o19uwryp.txt === reduce.pl bib === id = cord-285772-4xt4anq5 author = Huang, Rui title = Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study date = 2020-05-08 pages = extension = .txt mime = text/plain words = 3379 sentences = 217 flesch = 59 summary = This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. Several studies have reported the clinical characteristics of COVID-19 patients who were hospitalized in Wuhan (the outbreak center of the infection) [4, 6, 7] . conducted a retrospective, single-center study which included 99 confirmed cases of COVID-19 in Wuhan and found that the virus was more likely to infect older men with comorbidities, and the mortality rate was as high as 11% [4] . Another single-center study which analyzed 138 hospitalized patients with confirmed COVID-19 in Wuhan, found that 26% of patients received ICU care and the mortality rate was only 4.3% [7] . In this multi-center study, we aimed to describe the clinical characteristics of COVID-19 and to identify the risk factors of severe illness among inpatients with confirmed COVID-19 in Jiangsu province, which is located in the east of China. cache = ./cache/cord-285772-4xt4anq5.txt txt = ./txt/cord-285772-4xt4anq5.txt === reduce.pl bib === id = cord-287117-3v9nyagt author = Monteagudo, Luke Adam title = Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome date = 2020-04-21 pages = extension = .txt mime = text/plain words = 4638 sentences = 266 flesch = 47 summary = OBJECTIVE: The objective of this study was to report the benefit of a therapeutic approach consisting of intravenous (IV) continuous anakinra (recombinant human interleukin‐1 receptor antagonist) infusions in treating severely ill adult patients with secondary hemophagocytic lymphohistiocytosis or macrophage activation syndrome (MAS). The diagnosis of MAS was made using the HLH-2004 criteria, which require five of the eight following findings: fever greater than or equal to 38.5°C, splenomegaly; peripheral blood cytopenias (at least two of the following: hemoglobin level less than 9 g/dl, platelet count less than 100 000 cells per μl, and absolute neutrophil count less than 1000 cells per μl); hypertriglyceridemia (fasting triglyceride level greater than 265 mg/dl) and/or hypofibrinogenemia (fibrinogen level less than 150 mg/dl); hemophagocytosis in the bone marrow, spleen, lymph node, or liver; low or absent natural killer cell activity; ferritin level greater than 500 ng/ml; and elevated soluble CD25 levels (sIL-2Rα) two SDs above age-adjusted laboratory-specific norms. cache = ./cache/cord-287117-3v9nyagt.txt txt = ./txt/cord-287117-3v9nyagt.txt === reduce.pl bib === id = cord-286293-f5qg7vcz author = Ullah, Waqas title = COVID-19 complicated by Acute Pulmonary Embolism and Right-Sided Heart Failure date = 2020-04-17 pages = extension = .txt mime = text/plain words = 1094 sentences = 78 flesch = 47 summary = Since the end of December 2019, when the first cases of novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) were detected in Wuhan, China, the disease has spread exponentially. [2] In up to 15% of patients, the natural course of the disease is complicated by severe interstitial pneumonia, which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure including acute kidney injury, disseminated intravascular coagulation and death. [2] To our knowledge, there have been no reported cases of COVID-19 complicated by massive pulmonary embolism and right-sided heart failure. [4] A higher risk of vessel thrombosis has been correlated with the severity of the disease and multiorgan involvement, leading support to the argument of therapeutic anticoagulation of COVID-19 patients with elevated d-dimer levels. In the present case, the patient had elevated CRP and d-dimer levels with no other risk factor for pulmonary embolism, indicating COVID-19 related hypercoagulable state as possible etiology for thrombosis in the pulmonary vasculature. cache = ./cache/cord-286293-f5qg7vcz.txt txt = ./txt/cord-286293-f5qg7vcz.txt === reduce.pl bib === id = cord-286611-e1i1wemo author = Benziger, Catherine P. title = The Telehealth Ten: A Guide for a Patient-Assisted Virtual Physical Exam date = 2020-07-18 pages = extension = .txt mime = text/plain words = 1781 sentences = 114 flesch = 62 summary = We propose the "Telehealth Ten", which is a patient-assisted clinical examination to help guide clinicians through this new territory. Observing the patient's gait and level of effort to walk into the room and to sit up on the exam table can be useful to assess his or her functional performance. This evaluation can be enhanced using digital devices, such as wearables for heart rate and electrocardiogram (ECG) and home monitoring devices (scale, blood pressure cuff, and pulse oximeter), which are potentially available to patients. We propose the "Telehealth Ten", which is a patient-assisted clinical examination to help guide clinicians through this new territory (Table 1) . We recommend that patients use a validated, digital, upper arm blood pressure (BP) cuff to measure their BP and heart rate and an electronic scale for measuring daily body weight. Ask patients to look at their face, neck, arms including elbows, chest, abdomen, and legs. cache = ./cache/cord-286611-e1i1wemo.txt txt = ./txt/cord-286611-e1i1wemo.txt === reduce.pl bib === id = cord-286853-9gbel3pq author = Kim, Jiwon title = Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19 date = 2020-10-27 pages = extension = .txt mime = text/plain words = 2125 sentences = 108 flesch = 35 summary = BACKGROUND: Coronavirus disease 2019 (COVID-19) is a growing pandemic that confers augmented risk for right ventricular (RV) dysfunction and dilation; the prognostic utility of adverse RV remodeling in COVID-19 patients is uncertain. OBJECTIVES: The purpose of this study was to test whether adverse RV remodeling (dysfunction/dilation) predicts COVID-19 prognosis independent of clinical and biomarker risk stratification. Cardiac injury has also been reported to predict prognosis among COVID-19-infected patients, as evidenced by outcomes data that troponin elevation was present in 46% of nonsurvivors as opposed to 1% of survivors (5) and was associated with a >10-fold increased risk of mortality among hospitalized COVID-19 patients (6) . Related to this, it is important to note that whereas our results demonstrate adverse RV remodeling to strongly predict mortality in critically ill patients with COVID-19, available study data was insufficient to establish the mechanism for RV dilation or dysfunction. cache = ./cache/cord-286853-9gbel3pq.txt txt = ./txt/cord-286853-9gbel3pq.txt === reduce.pl bib === id = cord-286843-8qh1pblc author = Quah, Jessica title = Impact of microbial Aetiology on mortality in severe community-acquired pneumonia date = 2018-09-04 pages = extension = .txt mime = text/plain words = 4060 sentences = 215 flesch = 38 summary = Univariate and multivariate logistic regression showed that serum procalcitonin, APACHE II severity score and mixed viral-bacterial infection were associated with increased risk of hospital mortality. Postulated prohibitive factors against the routine performance of viral diagnostics tests in patients with severe CAP may include a lack of clear clinical guidelines, perceived low cost-effectiveness and the paucity of effective anti-viral therapies for respiratory viruses other than influenza. Our primary hypothesis was that respiratory viruses were important causative pathogens in severe CAP and was associated with increased mortality when present with bacterial pathogens in mixed viral-bacterial co-infections. performed a prospective observational study on physician practices in the use of respiratory virus diagnostics demonstrating that despite clinical guideline recommendations on testing of respiratory viruses during influenza season, less than half of patients admitted to the intensive care unit with pneumonia were tested for viral pathogens [14] . cache = ./cache/cord-286843-8qh1pblc.txt txt = ./txt/cord-286843-8qh1pblc.txt === reduce.pl bib === id = cord-287515-oe7adj91 author = Rello, Jordi title = Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China date = 2020-03-03 pages = extension = .txt mime = text/plain words = 1381 sentences = 76 flesch = 44 summary = Prior experience with viral pneumonia, including influenza and MERS-coronavirus, suggest that steroids can contribute to higher mortality, increase viral replication with longer periods of viral clearance and more superinfections (including invasive pulmonary aspergillosis, as already reported in the Wuhan cohort) [5, 6] . Another difference is that most COVID-19 infected patients were diagnosed with viral pneumonia, whereas acute exacerbations of COPD or bronchospasm or myocarditis were more common in influenza. Use of noninvasive ventilation is controversial, showing limited efficacy in MERS and is associated with very high levels of aerosol spread, exposing staff at much greater risk of infection [11, 12] . Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a singlecentered, retrospective, observational study High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A/H1N1 v cache = ./cache/cord-287515-oe7adj91.txt txt = ./txt/cord-287515-oe7adj91.txt === reduce.pl bib === id = cord-287468-e5h4tmy6 author = Lopez, Alexandre title = Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results date = 2020-08-08 pages = extension = .txt mime = text/plain words = 1978 sentences = 124 flesch = 52 summary = The primary objective of our study was to assess the effects of hydroxychloroquine according to its plasma concentration in ICU patients. reported that hydroxychloroquine and azithromycin was associated with viral load reduction in nasopharyngeal samples in patients after six days of treatment [6] . The Surviving Sepsis Campaign guidelines on the management of Covid-19 patients concluded there was insufficient evidence to recommend the use of antiviral drugs and hydroxychloroquine in ICU patients [7] . Confirmed Covid-19 patients with acute respiratory failure were included in the study if they completed the criteria: i) age of 18 or older and; ii) polymerase chain reaction (PCR) documented SARS-CoV-2 in nasopharyngeal samples upon ICU admission. In conclusion, our results showed that there was no association between the plasma concentration of hydroxychloroquine and the viral and clinical evolution of ICU patients admitted for Covid-19. cache = ./cache/cord-287468-e5h4tmy6.txt txt = ./txt/cord-287468-e5h4tmy6.txt === reduce.pl bib === id = cord-287373-7xjn05k8 author = Lian, Xin title = Under the coronavirus disease 2019(COVID-19) pandemic circumstance, how to administrate cancer patients with fever during radiotherapy date = 2020-06-05 pages = extension = .txt mime = text/plain words = 374 sentences = 23 flesch = 54 summary = key: cord-287373-7xjn05k8 title: Under the coronavirus disease 2019(COVID-19) pandemic circumstance, how to administrate cancer patients with fever during radiotherapy cord_uid: 7xjn05k8 2.The screen process of patient with fever during radiotherapy in the center. All fever patients were screened by fever clinic with COVID 2019 nucleic acid, Patients with fever had been suspended from radiation therapy until the outcome of negative screen test results and the relive of fever symptoms, the average duration of suspension was 5.5 days (3-11), see figure 2 for details. It is suggested that fever patients with anti-tumor therapy during COVID-19 epidemic should carefully be concerned. Scientific and reasonable arrangements for the treatment and strict screen procedure for fever patient will ensure the maximization of the rights and interests of cancer patients. Risk of COVID-19 for patients with cancer COVID-19 outbreak and cancer patient management: viewpoint from radio-oncologists cache = ./cache/cord-287373-7xjn05k8.txt txt = ./txt/cord-287373-7xjn05k8.txt === reduce.pl bib === id = cord-287222-wojyisu0 author = Zhou, Min title = Coronavirus disease 2019 (COVID-19): a clinical update date = 2020-04-02 pages = extension = .txt mime = text/plain words = 5683 sentences = 276 flesch = 35 summary = Of the first 99 laboratory-confirmed patients, 49 (49%) had been exposed to HSWM, which was reported to be the possible initial source of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) [5] . New Coronavirus Infection Diagnosis and Treatment Scheme (Trial Version) published by Military Support Hubei Medical Team also put forward that for mild to moderate COVID-19 patients, corticosteroids should not be given principally and highdose corticosteroid pulse therapy was not recommended. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19) cache = ./cache/cord-287222-wojyisu0.txt txt = ./txt/cord-287222-wojyisu0.txt === reduce.pl bib === id = cord-287210-sars5dmi author = Woo, Patrick C. Y. title = Clinical and Molecular Epidemiological Features of Coronavirus HKU1–Associated Community-Acquired Pneumonia date = 2005-12-01 pages = extension = .txt mime = text/plain words = 3345 sentences = 206 flesch = 56 summary = However, the clinical and molecular epidemiological features of CoV-HKU1–associated pneumonia are unknown MethodsProspectively collected (during a 12-month period) nasopharyngeal aspirates (NPAs) from patients with community-acquired pneumonia from 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection of CoV-HKU1. All prospectively collected NPAs from patients with community-acquired pneumonia that were sent to the clinical microbiology laboratories of 4 hospitals in Hong Kong during a 12-month period (22 March 2003 [the beginning of the SARS epidemic in Hong Kong] to 21 March 2004) for detection of SARS-CoV and were found to be negative for SARS-CoV RNA, by reverse-transcription polymerase chain reaction (RT-PCR) [20] , were included in the study. Sequence analysis revealed 0%-2% nucleotide differences between the sequences of the fragments and the sequence of the pol gene from The epidemiological, clinical, and radiological characteristics of the 10 patients with CoV-HKU1-associated community-acquired pneumonia are summarized in table 2. cache = ./cache/cord-287210-sars5dmi.txt txt = ./txt/cord-287210-sars5dmi.txt === reduce.pl bib === id = cord-287508-133inel2 author = Vasudevan, Rajiv S. title = Persistent Value of the Stethoscope in the Age of COVID-19 date = 2020-06-19 pages = extension = .txt mime = text/plain words = 3738 sentences = 189 flesch = 39 summary = • Stethoscopes are clinically valuable and integral to the doctor-patient connection; • Technological advancement will augment the utility of the stethoscope; • The stethoscope has high utility for assessment of COVID-19 patients; • Pathogen contamination in light of COVID-19 is a concern for the stethoscope; • Innovations in stethoscope hygiene will allow safe auscultation. During times of increased concern about contamination and spread of infections, physicians may opt to forgo their stethoscopes due to a lack of clear guidance on cleaning, lack of access to proper hygiene materials, or inconvenience with current personal protective equipment guidelines. Rather than forgoing a tool that might be useful in the prognostication of infected patients with cardiopulmonary abnormalities, it is important that novel hygienic and technological interventions be investigated to allow safe usage of the stethoscope. Advances in stethoscope technology will improve the auscultatory capabilities of health care workers and allow less contact with patients in transmission-based precautions. cache = ./cache/cord-287508-133inel2.txt txt = ./txt/cord-287508-133inel2.txt === reduce.pl bib === id = cord-287367-1sdt9zz8 author = Andrews, Denise title = Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use date = 2017-10-10 pages = extension = .txt mime = text/plain words = 6429 sentences = 297 flesch = 48 summary = title: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use Consequently, though respiratory viruses are frequently isolated in community acquired pneumonia (CAP) [2] and are reported to be responsible for 12.8% of CAP cases admitted to UK hospitals [3] , the decision to manage as a viral RTI or treat for bacterial infection including Mycoplasma pneumoniae or Chlamydia pneumoniae ('atypical bacteria') is based upon the clinical scenario and severity criteria such as the CURB-65 score. We undertook a study to assess the FilmArray® RP panel as a POC test compared to routine, laboratory-based detection methods in order to assess the impact on length of stay and antibiotic utilization. The aim of the study was to determine whether in adults presenting with upper respiratory tract infection (URTI)/ influenza-like illness (ILI) +/− lower respiratory tract infection (LRTI), FilmArray® RP panel POC testing, when compared to the routine, laboratory-based RP testing was associated with length of hospital stay or antimicrobial use. cache = ./cache/cord-287367-1sdt9zz8.txt txt = ./txt/cord-287367-1sdt9zz8.txt === reduce.pl bib === id = cord-287161-hqrql1lh author = McGrail, D. E. title = COVID-19 Case Series at UnityPoint Health St. Lukes Hospital in Cedar Rapids, IA date = 2020-07-19 pages = extension = .txt mime = text/plain words = 2237 sentences = 146 flesch = 48 summary = A retrospective, descriptive study of all patients tested for SARS-CoV2 on admission for illness to a community hospital in Iowa from 3/21/20 thru 6/14/20 consisted of evaluation as to demographics, presentation and hospital course. Overall survival of the COVID-19 patients was 88%, 77% in the critically ill, 59% of those mechanically ventilated and 33% of those requiring new dialysis. In this case series, we aim to describe epidemiological, clinical, laboratory, and treatment outcomes of confirmed COVID-19 patients admitted 3/21/2020 thru 6/14/2020 to UPH St. Luke's Hospital, one of the two hospitals in Cedar Rapids. This early peak in ICU resources is a reflection of transitioning from an early intubation intervention for COVID-19 related acute hypoxic respiratory failure to a strategy of utilizing high flow nasal cannula and noninvasive ventilation(i.e BiPAP) as supported in the literature 15 . In addition, our data indicates a significant portion of the critically ill patients whom were mechanically ventilated required hemodialysis support, 47%(9 of 19). cache = ./cache/cord-287161-hqrql1lh.txt txt = ./txt/cord-287161-hqrql1lh.txt === reduce.pl bib === id = cord-287520-51kmd2ds author = Carneiro, Arie title = Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date = 2020-05-20 pages = extension = .txt mime = text/plain words = 4537 sentences = 282 flesch = 49 summary = Therefore, most worldwide authorities are recommending to avoid, as much as possible, patient's elective visits to hospitals, as well as a judicious use of the operating room in order to mitigate the strain put on the health system. If it is not possible to separate an entire surgical block, we suggest designating specific rooms for the care of patients with COVID-19 that will not be used for regular cases. The gold standard test for investigation of the upper urinary tract is uro-tomography, but in times when we need to consider the use of resources, ultrasound could potentially be used since many imaging services are overloaded due to the frequent indication of thoracic CTs for the diagnosis and follow-up of patients with Sars-Cov-2. -In Intermediate-risk and high-risk non--muscle-invasive bladder cancers: Clinically fit patients with no major comorbidities should receive induction therapy followed by at least 1-year maintenance BCG. cache = ./cache/cord-287520-51kmd2ds.txt txt = ./txt/cord-287520-51kmd2ds.txt === reduce.pl bib === id = cord-286607-5i406twr author = Esposito, Susanna title = The Gut Microbiota-Host Partnership as a Potential Driver of Kawasaki Syndrome date = 2019-04-05 pages = extension = .txt mime = text/plain words = 6223 sentences = 250 flesch = 30 summary = Kawasaki syndrome (KS) is a necrotizing vasculitis of smalland medium-sized vessels mostly affecting children under 5 years of age; a host of clinical and epidemiological data supports the notion that KS might result from an infectious disease. All studies available to date have confirmed that an imbalance in the gut microbiota might indirectly interfere with the normal function of innate and adaptive immunity, and that variable microbiota interactions with environmental factors, mainly infectious agents, might selectively drive the development of KS in genetically susceptible children. The microbiota, a microbial community of trillions of microorganisms and at least 1,000 different bacterial species, some eukaryotic fungi and viruses, and which covers every surface of the human body, plays a contributory role in many infections, immune-mediated disorders, rheumatologic diseases, and disorders of the nervous system. cache = ./cache/cord-286607-5i406twr.txt txt = ./txt/cord-286607-5i406twr.txt === reduce.pl bib === id = cord-287544-n32iscmr author = Solaimanzadeh, Isaac title = Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19 date = 2020-05-12 pages = extension = .txt mime = text/plain words = 5448 sentences = 282 flesch = 41 summary = title: Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19 A retrospective review was conducted on CCB use in hospitalized patients in search of any difference in outcomes related to specific endpoints: survival to discharge and progression of disease leading to intubation and mechanical ventilation. Nifedipine and amlodipine were found to be associated with significantly improved mortality and a decreased risk for intubation and mechanical ventilation in elderly patients hospitalized with COVID-19. Nifedipine and amlodipine were found to be associated with significantly improved mortality and a decreased risk for intubation and mechanical ventilation in elderly patients hospitalized with COVID-19. A retrospective review of patients on either nifedipine or amlodipine was conducted in search of any difference in outcomes, including survival to discharge and progression of disease leading to intubation and mechanical ventilation. cache = ./cache/cord-287544-n32iscmr.txt txt = ./txt/cord-287544-n32iscmr.txt === reduce.pl bib === id = cord-287558-yc8aw2pg author = Duffy, Eamon Y. title = Primary and Secondary Prevention of Cardiovascular Disease in the Era of the Coronavirus Pandemic date = 2020-04-20 pages = extension = .txt mime = text/plain words = 707 sentences = 41 flesch = 38 summary = Telemedicine and remote monitoring will make it easier to frequently reach patients to optimize risk factor control, titrate medications, assess diets and physical activity levels, and integrate reminders to meet daily goals, among other capabilities. Besides health implications, the economic effect of the COVID-19 pandemic will be enormous and preventive cardiologists will need to adapt to a landscape of potential economic recession, with some patients facing financial hardship. The same will be true for research on patient-and context-level determinants associated with adverse cardiovascular outcomes during lockdowns and on opportunities to improve these. Marked advances in telemedicine in the post-COVID-19 era will provide an opportunity to enhance the care of primary and secondary prevention patients, with implications not only for CVD outcomes but also for reducing the burden of complications and deaths in current and future viral outbreaks. cache = ./cache/cord-287558-yc8aw2pg.txt txt = ./txt/cord-287558-yc8aw2pg.txt === reduce.pl bib === id = cord-287648-nhsn4cru author = Cameli, Matteo title = Usefulness of echocardiography to detect cardiac involvement in COVID‐19 patients date = 2020-07-12 pages = extension = .txt mime = text/plain words = 3041 sentences = 160 flesch = 36 summary = Therefore, the use of echocardiography, according to the safety local protocols and ensuring the use of personal protective equipment, could be useful firstly to discriminate between primary cardiac disease or COVID‐19–related myocardial damage, and then for assessing and monitoring COVID‐19 cardiovascular complications: acute myocarditis and arrhythmias, acute heart failure, sepsis‐induced myocardial impairment, and right ventricular failure derived from treatment with high‐pressure mechanical ventilation. 7 In two studies by Shi et al 8 and Guo et al, 9 among 460 and 187 patients hospitalized for COVID-19, respectively, 20% and 28% had acute myocardial injury, which was associated with higher mortality and incidence of complications, such as acute respiratory distress syndrome (ARDS), malignant arrhythmias, acute renal injury, and coagulopathy. 21 Accordingly, current reports suggest that the majority of COVID-19 patients with myocardial injury without evidence of epicardial coronary artery thrombosis, show imaging data supporting the diagnosis of acute myocarditis 21, 22 ; also, cases of fulminant myocarditis and fatal arrhythmias have been described. cache = ./cache/cord-287648-nhsn4cru.txt txt = ./txt/cord-287648-nhsn4cru.txt === reduce.pl bib === id = cord-287376-wxldnlih author = Krüger, Colin M. title = Can surgery follow the dictates of the pandemic “keep your distance”? Requirements with COVID-19 for hygiene, resources and the team date = 2020-08-03 pages = extension = .txt mime = text/plain words = 3977 sentences = 218 flesch = 46 summary = Finally, the choice of surgical method, whether open surgery or minimally invasive procedures, is critical in determining how many colleagues are exposed to the risk of infection from COVID-19 patients, sometimes for hours. Here, robot-assisted surgery can comply with the pandemic's requirement to "keep your distance" in a unique way, since the surgeon can operate at virtually any distance from the surgical site, at least with regard to aerosol formation and exposure. There were two central factors in the German hospital landscape that led to the restrictions described below: First, the call by the German Federal Ministry of Health to substantially increase the number of intensive care beds which would allow invasive ventilation of patients by temporarily postponing elective procedures; and second, the shortage of personal protective equipment (PPE), which is mainly produced in China, that accompanied the beginning of the pandemic. cache = ./cache/cord-287376-wxldnlih.txt txt = ./txt/cord-287376-wxldnlih.txt === reduce.pl bib === id = cord-287786-zfe0el8i author = Dudoignon, Emmanuel title = Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19 date = 2020-06-18 pages = extension = .txt mime = text/plain words = 1011 sentences = 69 flesch = 49 summary = title: Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19 Abstract The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. Characterisation and understanding of COVID-19 renal injury would improve the management of patients admitted to the intensive care unit (ICU). Here, we describe the renal response of patients with COVID-19 patients admitted to an intensive care unit (ICU), with a particular focus on the activation of the renin-angiotensin-aldosterone system. Patients admitted to the ICU of St-Louis Hospital (Paris) between March 22 and April 15, 2020 for acute respiratory distress syndrome (Berlin Definition [7] ) with acute kidney injury (AKI, defined according to the Kidney Disease-Improving Global Outcome criteria [8] and using the admission serum creatinine as the baseline) were screened. Patients with AKI showed direct (increased plasma renin and aldosterone concentration) and indirect (low urine sodium concentration) markers of activation of the RAAS [3] . cache = ./cache/cord-287786-zfe0el8i.txt txt = ./txt/cord-287786-zfe0el8i.txt === reduce.pl bib === id = cord-286334-d9v5xtx7 author = Li, Rui title = Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date = 2020-04-30 pages = extension = .txt mime = text/plain words = 12955 sentences = 719 flesch = 50 summary = More detailed monitoring on how these physiological parameters change over time (perhaps including more complex cytokine studies), in these severely ill, influenza A(H1N1)pdm09-infected patients admitted to ICU-ECMO units, may eventually yield data to improve their management and clinical outcomes. 5 In the current study, we characterized a new HCV subtypes among chronic hepatitis C patients in Yunnan, China, initially designated as 6xi, further analyzed its evolutionary history and investigated its baseline RAS by next generation sequencing (NGS) method. The samples met the following inclusion criteria: (1) hepatitis C antibody-positive for 6 months with normal serum alanine aminotransferase (ALT) levels; (2) subject was residing in Yunnan province and was over 18 years old; (3) complete demographic information and clinical data were available; (4) consented to the use of patient information in studies on HCV epidemics; and (5) were treatment-naïve during sampling. cache = ./cache/cord-286334-d9v5xtx7.txt txt = ./txt/cord-286334-d9v5xtx7.txt === reduce.pl bib === id = cord-287538-qbf5lv7d author = Nucera, Eleonora title = Latex Allergy: Current Status and Future Perspectives date = 2020-09-28 pages = extension = .txt mime = text/plain words = 6676 sentences = 354 flesch = 42 summary = The following eligibility criteria were used for article inclusion: population: patients with latex allergy and/or at risk for anaphylaxis; intervention: any approaches or protocols that incorporated a strategy for latex allergy and anaphylaxis management; comparator: any studies irrespective of whether there was a comparator included in the study design; outcomes: any related to prevalence, diagnostics, and treatments including primary prevention and immunotherapy; and study design: experimental studies and observational studies. 65 On the other hand, only a small case series of nine patients has described the efficacy of accelerator-free medical gloves in the secondary prevention of allergic contact dermatitis (ACD) caused by rubber accelerators in HCWs. 66 Gentili et al 67 showed that an effective and exemplary example of secondary prevention of latex allergy is feasible for infants born with spina bifida. cache = ./cache/cord-287538-qbf5lv7d.txt txt = ./txt/cord-287538-qbf5lv7d.txt === reduce.pl bib === id = cord-287505-ihqzpdar author = Narain, Sonali title = Comparative Survival Analysis of Immunomodulatory Therapy for COVID-19 'Cytokine Storm' date = 2020-10-17 pages = extension = .txt mime = text/plain words = 3650 sentences = 222 flesch = 42 summary = Patients were subdivided into six groups—no immunomodulatory treatment (standard of care) and five groups that received either corticosteroids, anti-interleukin 6 antibody (tocilizumab) or anti-interleukin-1 therapy (anakinra) alone or in combination with corticosteroids. Furthermore, corticosteroid use either alone or in combination with tocilizumab or anakinra was associated with reduced hospital mortality for patients with COVID-19 cytokine storm compared to standard of care. In this retrospective study, we leveraged this natural experiment to compare mortality in patients meeting criteria for CCS who received different combinations of these immunomodulatory drugs. Primary objective: To compare in-hospital mortality among COVID-19 patients with CCS who received combinations of immunomodulatory treatments versus SoC. Our study is the largest retrospective analysis to date reporting on outcomes comparing the use of immunomodulatory therapies such as corticosteroids, tocilizumab and anakinra in the treatment of COVID-19 CCS. Corticosteroid use, either alone or in combination with tocilizumab or anakinra, was associated with lower hospital mortality compared to standard of care. cache = ./cache/cord-287505-ihqzpdar.txt txt = ./txt/cord-287505-ihqzpdar.txt === reduce.pl bib === id = cord-287497-93oiiqqi author = Tagliamento, Marco title = Italian survey on managing immune checkpoint inhibitors in oncology during COVID‐19 outbreak date = 2020-06-14 pages = extension = .txt mime = text/plain words = 3228 sentences = 199 flesch = 49 summary = The objectives of this survey were to examine the impact of COVID-19 outbreak on the perception of Italian physicians involved in the administration of ICIs about SARS-CoV-2 related risks in cancer patients receiving these therapies, and their attitudes towards the management of ICIs in oncology. The perception of respondents regarding the potential increased risk of severe events related to SARS-CoV-2 infection in cancer patients treated with ICIs is displayed in Figure 1B . 17 Moreover, besides the overlapping between cancer-related signs/symptoms or side effects of oncological treatments (including irAEs) and COVID-19 manifestations, additional issues could emerge from the differential diagnosis between radiological findings of lung involvement from SARS-CoV-2 and pneumonitis induced by ICIs. 9, 24 To the best of our knowledge, this is the first study exploring the perception of physicians towards these unsolved issues, and whether the outbreak has modified the clinical practice in managing the treatment with ICIs in oncology. cache = ./cache/cord-287497-93oiiqqi.txt txt = ./txt/cord-287497-93oiiqqi.txt === reduce.pl bib === id = cord-287742-y1j9x5ne author = Lee, Kai Wei title = Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis date = 2020-10-06 pages = extension = .txt mime = text/plain words = 6545 sentences = 292 flesch = 45 summary = Therefore, we performed a systematic review and meta-analysis of currently available epidemiological, clinical, and laboratory data related to both stroke and COVID-19 infection. We, therefore, performed a systematic review and metaanalysis involving the epidemiological, clinical presentation, imaging characteristics, and laboratory finding related to both stroke and COVID-19 infection. The following data were extracted from every study: the last name of the first author, year of publication, country, severity status, study design, patient characteristics (ethnicity composition, gender, and mean age), comorbidities (diabetes, hyperlipidemia, hypertension, ischemic heart disease, heart failure, previous stroke, chronic kidney disease/end-stage renal disease, number of stroke patients per overall participants, any information relevant to strokes such as the location of stroke [arterial or venous]), types of stroke (ischemic or haemorrhagic), classification of stroke, mortality rate, and blood parameters. The aim of this current study is to perform a systematic review and meta-analysis concerning the epidemiological, clinical presentation, imaging characteristics, and laboratory findings related to both stroke and COVID-19 infection. cache = ./cache/cord-287742-y1j9x5ne.txt txt = ./txt/cord-287742-y1j9x5ne.txt === reduce.pl bib === id = cord-287901-56goaqir author = Maudgil, D.D. title = Cost effectiveness and the role of the National Institute of Health and Care Excellence (NICE) in interventional radiology date = 2020-10-17 pages = extension = .txt mime = text/plain words = 5021 sentences = 276 flesch = 46 summary = Costs for the same procedure can vary widely, e.g., the "Getting it Right First Time" (GIRFT) Vascular Surgery report noted that reported cost for elective endovascular aortic repair (EVAR) varied between £2,251 and £19,690 for no apparent reason and with no indication that lower cost procedures were less effective 2,4 ; CES encompass a wider societal perspective than just the clinician's or patient's point of view alone, helping demonstrate equitable resource allocation in a publicly funded service 3 ; CES allow evaluation of short-and long-term costs and benefits, which are often under-or overestimated; and 4 CES provide an explicit and accountable framework for decision making, which can be re-examined as data accumulate, particularly important with evolving techniques and experience as in interventional radiology (IR). cache = ./cache/cord-287901-56goaqir.txt txt = ./txt/cord-287901-56goaqir.txt === reduce.pl bib === id = cord-287765-nsdequl9 author = Taiwo, Olutosin title = Smart healthcare support for remote patient monitoring during covid-19 quarantine date = 2020-09-15 pages = extension = .txt mime = text/plain words = 7111 sentences = 359 flesch = 50 summary = To this end, a remote smart home healthcare support system (ShHeS) is proposed for monitoring patients' health status and receiving doctors' prescriptions while staying at home. In this paper, we propose a mobile application-based prototype smart home healthcare system for efficient and effective health monitoring for the elderly and disabled for their convenient and independent living while at home. Smart home automation as an emerging area of IoT has been applied in various areas such as: easy and assisted daily living especially for the provision of support to humans [17] , remote control of home appliances [18, 19] , detection of movement in the house [20] , energy management in the home [21] and security [22] , and provision of healthcare services to out-patients, disabled and elderly persons [10, 23, 24] . The proposed system described in our work is intended to perform a dual function of controlling home appliances as well as monitoring and recording the patient's physiological data such as blood pressure, body temperature, pulse rate, body weight and sugar level and other symptoms related to a specific virus. cache = ./cache/cord-287765-nsdequl9.txt txt = ./txt/cord-287765-nsdequl9.txt === reduce.pl bib === id = cord-287957-diyz54qy author = Deriba, Berhanu Senbeta title = Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities date = 2020-10-13 pages = extension = .txt mime = text/plain words = 4256 sentences = 226 flesch = 45 summary = title: Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities Therefore, this study aimed to assess patient satisfaction and associated factors among chronic patients who had a follow-up in North Shoa healthcare facilities. Therefore, this study aimed to assess patient satisfaction and associated factors during the COVID-19 pandemic among chronic patients who had follow-up at public health facilities in the North Shoa Zone, Oromia region, Ethiopia. Patients who maintained and observed better social distancing at the registration place, waiting for the outpatient department, laboratory, and pharmacy services as a means of the COVID-19 prevention in the healthcare facilities were significantly associated with patient satisfaction. Availability of sign and direction indicators, availability of ordering drugs, social distancing status in the healthcare facility, availability of alcohol, and sanitizer for hand cleaning at the healthcare facility entrance to prevent and control COVID-19 were factors associated with the satisfaction of patients with chronic diseases. cache = ./cache/cord-287957-diyz54qy.txt txt = ./txt/cord-287957-diyz54qy.txt === reduce.pl bib === id = cord-287874-wl0wlxh6 author = Wang, Ling title = Quadruple therapy for asymptomatic COVID-19 infection patients date = 2020-05-03 pages = extension = .txt mime = text/plain words = 5530 sentences = 267 flesch = 45 summary = From 31 January 2020 to 10 February 2020, the patient was given quadruple therapy, including lopinavir/ritonavir tablets (400/100 mg every 12 h), arbidol tablets (0.2 g every 8 h), Lianhuaqingwen granules (a Chinese patent medicine, 6 g every 8 h) orally, and recombinant human interferon-α2b injection via aerosol (6.0 × 10 6 IU with 2 ml of sterilized water for injection every 12 h). • Quadruple therapy, which is lopinavir/ritonavir tablets, arbidol tablets, Lianhuaqingwen granules, and recombinant human interferon-α2b (IFN-α2b) injection via aerosol, is a common regimen for patients with COVID-19 in China. From 31 January 2020 to 10 February 2020, the patient was treated with four drugs, which are oral administration of lopinavir/ritonavir tablets (400/100 mg every 12 h), arbidol tablets (0.2 g every 8 h), and Lianhuaqingwen granules (a Chinese patent medicine, 6 g every 8 h) and atomization inhalation of recombinant human interferon-α2b injection (6.0 × 10 6 IU with 2 ml of sterilized water for injection every 12 h). cache = ./cache/cord-287874-wl0wlxh6.txt txt = ./txt/cord-287874-wl0wlxh6.txt === reduce.pl bib === id = cord-288033-9xu1ujcq author = Zeng, Jie title = How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People’s Hospital date = 2020-03-11 pages = extension = .txt mime = text/plain words = 431 sentences = 37 flesch = 56 summary = Combined with epidemiological history and body temperature screening, if suspected of SARS-CoV-2 infection, they will be admitted to the hospital isolation ward for rapid nucleic acid test. Patients suspected or diagnosed with SARS-CoV-2 infection should be isolated and begin thrombolytic therapy immediately, if within reperfusion time. High-risk patients with contraindications for thrombolysis need to assess the risk of infection and the benefit of PCI. In case of patients within the reperfusion time window and no contraindication to thrombolysis, thrombolytic therapy is performed in an isolation ward. Patients within the reperfusion time window with contraindications for thrombolysis or failure of thrombolysis need to comprehensively evaluate the risks of PCI and infection control. comprehensively evaluate the risks of PCI and infection control. The confirmed case should be transferred to the isolation ward until patient recovery and then it was assessed whether further invasive interventions are needed. cache = ./cache/cord-288033-9xu1ujcq.txt txt = ./txt/cord-288033-9xu1ujcq.txt === reduce.pl bib === id = cord-287732-abzpfdcu author = Martindale, Robert title = Nutrition Therapy in Critically Ill Patients with Coronavirus Disease (COVID‐19) date = 2020-05-27 pages = extension = .txt mime = text/plain words = 6232 sentences = 371 flesch = 42 summary = These variables have implications for nutritional interventions: [1] older patients are at-risk for pre-existing disease and sarcopenia which increases their risk for pre-existing malnutrition and increased risk of refeeding syndrome, [2] severe acute respiratory distress syndrome (ARDS) with refractory hypoxemia may require prone-positioning and/or extracorporeal membrane oxygenation (ECMO), [3] circulatory failure and concomitant feeding may increase the risk of gut ischemia and feeding intolerance, [4] multiple organ failure (MOF) and the need for early enteral nutrition (EN) to attenuate or mitigate gut derived inflammation, and [5] cytokine release syndrome which alters nutrient utilization (especially lipids). Recommendation 1: We recommend all healthcare providers, including dietitians, nurses, and physicians follow PPE standards set forth by the CDC and/or the WHO and adhere to their institutional guidelines when conducting bedside nutritional assessments for all patients with confirmed or suspected COVID-19 disease. cache = ./cache/cord-287732-abzpfdcu.txt txt = ./txt/cord-287732-abzpfdcu.txt === reduce.pl bib === id = cord-287895-63wy5ztb author = Aponte Martín, Diego Mauricio title = Use of a new face shield for patients of the endoscopy unit to avoid aerosol exchange in the COVID-19 era date = 2020-07-04 pages = extension = .txt mime = text/plain words = 932 sentences = 73 flesch = 61 summary = title: Use of a new face shield for patients of the endoscopy unit to avoid aerosol exchange in the COVID-19 era Because these procedures are performed in a contaminated environment, there is a higher risk that patients and health workers will be infected. Although there is an absence of new data about transmission of the virus as an aerosol, a previous study revealed that health workers who are exposed to this kind of procedure have a 4.66 times greater probability (95% confidence interval, 3.1-6.9) of infection in comparison with others. Our current interest in the Colombia University endoscopic unit is to decrease as much as possible aerosol contamination from patients and health workers. In conclusion, we have found that wearing the face shield we have specially designed results in less contact between the patient and the environment and yields an important decrease in the quantity of droplets and aerosols produced during the procedure. Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review cache = ./cache/cord-287895-63wy5ztb.txt txt = ./txt/cord-287895-63wy5ztb.txt === reduce.pl bib === id = cord-288158-6gicgsj8 author = Mahammedi, Abdelkader title = Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study date = 2020-05-21 pages = extension = .txt mime = text/plain words = 1099 sentences = 76 flesch = 46 summary = title: Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study Of 725 consecutive hospitalized patients with coronavirus disease 2019, 108 (15%) had acute neurologic symptoms necessitating neurologic imaging. Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study E271 10 had acute ischemic infarcts and two had intracranial hemorrhage. The main neurologic imaging hallmark was acute ischemic infarcts, which were present in 34 of the 108 patients (31%) (30 [28%] on CT scans and four [20%] on MRI scans). Our study demonstrated that the neurologic imaging features of hospitalized patients with COVID-19 were variable, without a specific pattern but dominated by acute ischemic infarcts and intracranial hemorrhages. Currently, we have a poor mechanistic understanding of the neurologic symptoms in patients with COVID-19, whether these are arising from critical illness or from direct central nervous system invasion of severe acute respiratory syndrome coronavirus 2 (10). cache = ./cache/cord-288158-6gicgsj8.txt txt = ./txt/cord-288158-6gicgsj8.txt === reduce.pl bib === id = cord-287953-prn8cnvo author = Shin, Nina title = Effects of operational decisions on the diffusion of epidemic disease: A system dynamics modeling of the MERS-CoV outbreak in South Korea date = 2017-05-21 pages = extension = .txt mime = text/plain words = 6245 sentences = 302 flesch = 41 summary = However, a number of hypotheses were generated to explain the spread, including: excessive patients' freedom in seeking medical care at only large hospitals, inadequate quarantine, questionable government transparency, such as belated reports of infected hospital names, and the cultural social norm of visiting patients as standard etiquette ( Choe, 2015a ( Choe, , 2015b ; Korea Centers for Disease Control and Prevention, 2015 ) . Using a macro-level system dynamics modeling approach, our study intends to investigate the effect of operational decisions, such as patient-room design, occupancy control at emergency room and patient-visitor management, on the patient-care performance, such as number of infected patients (secondary infections) and financial burden on patients. The model illustrated in Fig. 3 depicts a high-level overview dynamics model of causal relationships between operational decisions (patient room designs, occupancy control at emergency room, patient-visitor management) and patient care performance (number of infected patients and average cost per patient). cache = ./cache/cord-287953-prn8cnvo.txt txt = ./txt/cord-287953-prn8cnvo.txt === reduce.pl bib === id = cord-288040-uuqfvvmk author = Kapoor, Saloni title = Developing a pediatric ophthalmology telemedicine program in the COVID-19 crisis date = 2020-09-02 pages = extension = .txt mime = text/plain words = 3080 sentences = 175 flesch = 47 summary = Synchronous telemedicine can be further divided into encounters scheduled for the provider by a scheduler, with the patient being given specific instructions as to how to join a virtual clinic room at a given time or can be triggered by a patient wanting advice or an examination as the need arises, with a provider team available 24/7. The medical records of patients to be seen at the Ophthalmology Department of UPMC Children's Hospital of Pittsburgh between March 21 and April 10 were reviewed by a provider (MP, KKN, PP, EM, CL EK), and all visits in the study period were categorized as follows: (1) requiring an in-person visit, (2) face-to-face visit that could be postponed, and (3) consultation required but could be virtual. To ensure that patients were consistently informed that their physician deemed the visit to be necessary and that it could be completed via telemedicine, a standardized script was used by schedulers. cache = ./cache/cord-288040-uuqfvvmk.txt txt = ./txt/cord-288040-uuqfvvmk.txt === reduce.pl bib === id = cord-288102-iom6lu7o author = Han, Jing title = Analysis of factors affecting the prognosis of COVID-19 patients and viral shedding duration date = 2020-06-25 pages = extension = .txt mime = text/plain words = 4291 sentences = 226 flesch = 51 summary = The clinical characteristics of patients with COVID-19 were analysed to determine the factors influencing the prognosis and virus shedding time to facilitate early detection of disease progression. The clinical characteristics of 185 patients with COVID-19 diagnosed in Tianjin were analysed retrospectively to determine the factors affecting their prognoses and the duration of viral shedding with the aim of facilitating early treatment and improving patient prognosis. We found that a lower PaO 2 /FiO 2 at the time of admission is a risk factor for a poor prognosis in patients with severe COVID-19. In our study, univariate analysis results showed that age was a risk factor for prolonged viral shedding duration, but no significant difference was found in the multivariate Cox analysis. This study showed that diabetes mellitus, age, the time from symptom onset to treatment and PaO 2 /FiO 2 can predict the prognosis of patients with COVID-19. cache = ./cache/cord-288102-iom6lu7o.txt txt = ./txt/cord-288102-iom6lu7o.txt === reduce.pl bib === id = cord-288067-36amafub author = Ashraf, Mohammad Ali title = COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes date = 2020-04-24 pages = extension = .txt mime = text/plain words = 4374 sentences = 285 flesch = 56 summary = Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and post-discharge follow-up were analyzed. The most common presenting symptoms are non-specific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. We reported detailed information about the potential source of exposure, household contact information, outcomes of potential therapies, and post-discharge follow-up, as well as demographic, clinical, and paraclinical characteristics. Patients who came to the hospital were examined by an infectious-disease specialist, and classified into three groups according to disease severity based on Iran's national guideline for the diagnosis and treatment of COVID-19 in outpatients and inpatients (Figure1). We compared demographic characteristics, hospitalization data, and potential treatment outcomes in critically ill and non-critically ill patients. 12 Recent potential exposures, household contact information, demographics, clinical characteristics, laboratory, and radiologic findings, and patients' outcomes were extracted as shown in table1. cache = ./cache/cord-288067-36amafub.txt txt = ./txt/cord-288067-36amafub.txt === reduce.pl bib === id = cord-288222-8fqfbys2 author = Hardy, Michaël title = Prothrombotic Disturbances of Hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Study date = 2020-10-24 pages = extension = .txt mime = text/plain words = 1198 sentences = 69 flesch = 47 summary = The aim of this prospective study was therefore to describe the longitudinal changes in hemostasis parameters assessed daily in 21 COVID-19 patients during their intensive care unit (ICU) stay. Our main findings were that (i) daily standard measurements consistent with a prothrombotic state persisted over the first days and improved thereafter, but did not normalize in all patients; (ii) increased thrombin potential (hypercoagulability) and decreased fibrinolysis were frequent and (iii) a high inter-patient variability was observed. Patients initially were in a high inflammatory state (median CRP levels of 204 mg/dL during the first ten days after ICU admission); CRP levels progressively decreased over time thereafter. In light of these results and of the current knowledge on hemostasis disturbances of COVID-19 patients, we suggest that a close monitoring of a sensible set hemostatic parameters would be useful to assess individual thrombotic risk. cache = ./cache/cord-288222-8fqfbys2.txt txt = ./txt/cord-288222-8fqfbys2.txt === reduce.pl bib === id = cord-287758-da11ypiy author = Mônica Vitalino de Almeida, Sinara title = COVID-19 therapy: what weapons do we bring into battle? date = 2020-09-10 pages = extension = .txt mime = text/plain words = 17412 sentences = 1034 flesch = 45 summary = The increase in studies related to SARS-CoV-2 during the first semester in 2020 has allowed the rather speedy identification of promising therapeutic targets for both developing immunotherapies and producing/identifying antiviral drugs. 5, 64 So far, structural proteins and enzymes that participate actively in the process of viral replication are the most investigated targets for the development of molecules for anti-CoVs therapies (FIG. Based on results from previous studies as well, nelfinavir was considered a likely therapy for COVID-19 after its indication for clinical trials as a promising anti-SARS drug. 218 In addition to this well-known antitumor effect, imatinib has also shown in-vitro antiviral properties against several virus, such as infectious bronchitis virus (a viral model for studying the role of tyrosine kinase activity during CoV infection), by interfering with virus-cell fusion, 219 and other RNA viruses including coxsackie virus, 220 hepatitis C virus, 221 Ebola, 222 among others, mainly by blocking viral entry or egress from the host cell. cache = ./cache/cord-287758-da11ypiy.txt txt = ./txt/cord-287758-da11ypiy.txt === reduce.pl bib === id = cord-288009-8i3gsq9p author = Javor, S. title = Why not consider an endothelin receptor antagonist against SARS‐CoV‐2? date = 2020-04-25 pages = extension = .txt mime = text/plain words = 668 sentences = 50 flesch = 46 summary = Medical Hypotheses journal homepage: www.elsevier.com/locate/mehy Bosentan is a dual endothelin-receptor antagonist approved for the treatment of pulmonary arterial hypertension (PAH) in New York Heart Association functional classification (NYHA) II-IV and in scleroderma patients [10] . Guo et al [13] described a case of 57-year-old man with influenza A (H7N9) virus infection initially treated with empirical antibacterial therapy and oseltamivir with progression to acute respiratory distress syndrome and mechanical ventilation. Ritonavir and lopinavir, given together to sup-press HIV-replication, have been associated with bosentan to treat PAH in HIV-infected patients without dosage adjustment of protease inhibitors with good tolerability [14] . In conclusion, we think bosentan could be considered, in association with other approved drugs, in the treatment of SARS-CoV-2 to improve hemodynamics, potentiate antiviral effects and to prevent lung fibrosis. Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells cache = ./cache/cord-288009-8i3gsq9p.txt txt = ./txt/cord-288009-8i3gsq9p.txt === reduce.pl bib === id = cord-288271-p074ffpt author = Mathies, D. title = A Case of SARS‐CoV‐2‐pneumonia with successful antiviral therapy in a 77‐year‐old male with heart transplant date = 2020-04-21 pages = extension = .txt mime = text/plain words = 2473 sentences = 155 flesch = 52 summary = In this report, we present a 77‐year old patient with a heart transplant under relevant immunosuppressive therapy who was tested positive for SARS‐CoV‐2 after several days of dyspnoea, dry cough and light general symptoms. All rights reserved Diagnosis: SARS-CoV-2-Infection with viral pneumonia in a patient with heart transplant due to coronary artery disease with ischemic cardiomyopathy In this case the combination of radiologic signs of viral pneumonia and the supposed high-risk state of severe immunosuppression led to the decision to start an antiviral therapy immediately after receiving the positive rtPCR-results although the patient presented only mild symptoms. [13] A second question is whether patients with a solid organ transplant who receive immunosuppressive medication are at greater risk for a severe manifestation of a SARS-CoV 2-Infection or might even benefit from a reduced immunologic reaction. For SARS-CoV 2 we found two cases of patients with a heart transplant of which one had only mild manifestations and one required mechanical ventilation but survived [9] . cache = ./cache/cord-288271-p074ffpt.txt txt = ./txt/cord-288271-p074ffpt.txt === reduce.pl bib === id = cord-287991-10jz1dz2 author = Goshen-Lago, Tal title = The Potential Role of Immune Alteration in the Cancer–COVID19 Equation—A Prospective Longitudinal Study date = 2020-08-26 pages = extension = .txt mime = text/plain words = 4497 sentences = 235 flesch = 47 summary = Conclusion: Our results indicate a similar rate of asymptomatic COVID19 infection in cancer patients and healthcare workers in a longitudinal study throughout the pandemic time. During the study interval, there was no documented symptomatic case of COVID19 among the recruited participants, nor in the general patient population of the cancer center or in the healthcare workers cohort. Furthermore, when analyzing the myeloid lineage, we found a substantial increase in myeloid cells in cancer patients compared to healthcare workers (both SARS-CoV-2 IgG-), in line with previous studies [11, 12] . Our results may indicate that due to differential immune cell profile of cancer patients who are treated with immunomodulatory agents, the host response to the SARS-COV2 may lessen symptom severity. Our results may indicate that due to differential immune cell profile of cancer patients who are treated with immunomodulatory agents, the host response to the SARS-COV2 may lessen symptom severity. cache = ./cache/cord-287991-10jz1dz2.txt txt = ./txt/cord-287991-10jz1dz2.txt === reduce.pl bib === id = cord-288197-drto66xt author = Chen, Huijun title = Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records date = 2020-02-12 pages = extension = .txt mime = text/plain words = 3927 sentences = 225 flesch = 54 summary = METHODS: Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Findings from this small group of cases suggest that there is currently no evidence for intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia in late pregnancy. Evidence of vertical transmission was assessed by testing for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in amniotic fluid, cord blood, breastmilk, and neonatal throat swab samples from six of nine patients. Based on data from this small group of patients, there is currently no evidence of vertical transmission in pregnant women who develop COVID-19 pneumonia in the third trimester. cache = ./cache/cord-288197-drto66xt.txt txt = ./txt/cord-288197-drto66xt.txt === reduce.pl bib === id = cord-288558-rthnj6wd author = Cheng, V. C. C. title = Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome date = 2004-02-15 pages = extension = .txt mime = text/plain words = 3801 sentences = 201 flesch = 46 summary = The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log 10 vs. A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log 10 vs. In this retrospective study, we attempt to correlate the virus load of SARS coronavirus shedding from the nasopharynx, the upper end of the aerodigestive tract, with the presence of diarrhea in a cohort of patients with SARS. cache = ./cache/cord-288558-rthnj6wd.txt txt = ./txt/cord-288558-rthnj6wd.txt === reduce.pl bib === id = cord-288580-onzzpkye author = HALAÇLI, Burçin title = Critically ill COVID-19 patient date = 2020-04-21 pages = extension = .txt mime = text/plain words = 3805 sentences = 208 flesch = 46 summary = This pandemic is accepted as a viral pneumonia pandemic not a simple flu, therefore, intensive care unit (ICU) admission, follow-up, and management of the critically ill patients with COVID-19 is extremely important. HFNO therapy and NIMV support may be applied in selected hypoxemic respiratory failure cases with proper PPE because of high risk of aerosol generation. However, these patients should be followed closely in terms of clinical deterioration, if no positive response is obtained in the first few hours (refractory hypoxemia, tachypnoea, tidal volume (Vt) > 9 mL/kg meaning increased minute ventilation and work of breathing). In the light of the data obtained from COVID-19 pandemic and hospital follow-up of these critically ill patients, the needfulness of intensive care units with well-organized structure and trained HCW, has emerged once again. Expert consensus on preventing nosocomial transmission during respiratory care for critically ill patients infected by 2019 novel coronavirus pneumonia cache = ./cache/cord-288580-onzzpkye.txt txt = ./txt/cord-288580-onzzpkye.txt === reduce.pl bib === id = cord-288371-uyj4iske author = Arrieta, Oscar title = Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: The THOCOoP cooperative group date = 2020-06-20 pages = extension = .txt mime = text/plain words = 6664 sentences = 382 flesch = 46 summary = Long-term Follow-up on NRG Oncology RTOG 0915 (NCCTG N0927): A Randomized Phase 2 Study Comparing 2 Stereotactic Body Radiation Therapy Schedules for Medically Inoperable Patients With Stage I Peripheral Non-Small Cell Lung Cancer Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial. Phase III study of the Eastern Cooperative Oncology Group (ECOG 2597): induction chemotherapy followed by either standard thoracic radiotherapy or hyperfractionated accelerated radiotherapy for patients with unresectable stage IIIA and B non-small-cell lung cancer Usefulness of serum carcinoembryonic antigen (CEA) in evaluating response to chemotherapy in patients with advanced non small-cell lung cancer: a prospective cohort study Randomized phase III trial of single-agent pemetrexed versus carboplatin and pemetrexed in patients with advanced non-small-cell lung cancer and Eastern Cooperative Oncology Group performance status of 2 Carboplatin-or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data cache = ./cache/cord-288371-uyj4iske.txt txt = ./txt/cord-288371-uyj4iske.txt === reduce.pl bib === id = cord-288181-9thl46oe author = Fekkar, Arnaud title = Fungal Infection during COVID-19: Does Aspergillus Mean Secondary Invasive Aspergillosis? date = 2020-09-15 pages = extension = .txt mime = text/plain words = 1536 sentences = 92 flesch = 38 summary = The authors report a high incidence of presumed invasive pulmonary aspergillosis (6 of 31; 19.4%) among patients with coronavirus disease (COVID-19) admitted to intensive care. The association between aspergillosis and COPD is well known; in a recent prospective study, 14% of patients with COPD exacerbations had respiratory samples with Aspergillus spp. We thank Fekkar and colleagues for their thoughtful comments on our case series of patients with coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA) (1). Cohort studies in patients with influenza-associated pulmonary aspergillosis (IAPA) in the ICU demonstrated that any indication of Aspergillus through positive culture or galactomannan (GM) detection is highly indicative of invasive aspergillosis (2) . Reports of presumed CAPA cases that survive without antifungal therapy, such as those presented by Fekkar and Alanio, are very informative and suggest that in patients with COVID-19, Aspergillus colonization is more common compared with in patients with influenza (5) . cache = ./cache/cord-288181-9thl46oe.txt txt = ./txt/cord-288181-9thl46oe.txt === reduce.pl bib === id = cord-288255-p8uzrsbd author = Goossens, Gijs H. title = Obesity and COVID-19: A Perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity date = 2020-08-13 pages = extension = .txt mime = text/plain words = 7043 sentences = 333 flesch = 36 summary = authors: Goossens, Gijs H.; Dicker, Dror; Farpour-Lambert, Nathalie J.; Frühbeck, Gema; Mullerova, Dana; Woodward, Euan; Holm, Jens-Christian Evidence from studies in humans indicates that people with obesity are characterized by systemic low-grade inflammation, higher susceptibility to infections, dampened immune response to infectious agents, as well as higher morbidity and mortality associated with infections, and demonstrate an impaired immune response to vaccinations and antimicrobial treatment [25] [26] [27] [28] . Together, these findings imply that evaluation of cytokine profiles and immune cell subsets in patients with SARS-CoV-2 infection, and a deeper understanding of the underlying processes, will significantly contribute to better treatment strategies and clinical management of COVID-19 [37] . At the same time, the rapidly emerging clinical data require ongoing scrutiny to understand not only the risks and benefits of single drugs to tackle COVID-19, but also the interaction with pharmacological agents commonly used in people with obesity and related NCDs, including type 2 diabetes and cardiovascular diseases, who are especially at risk of or hospitalized with SARS-CoV-2 infection. cache = ./cache/cord-288255-p8uzrsbd.txt txt = ./txt/cord-288255-p8uzrsbd.txt === reduce.pl bib === id = cord-288051-wp8v2mc5 author = Sánchez-González, Álvaro title = What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date = 2020-09-01 pages = extension = .txt mime = text/plain words = 3616 sentences = 267 flesch = 47 summary = Seven days after the clinical onset, the risk of transmission decreases in mildsymptomatic patients, but it may be extended over 24 days in severe cases [11•, 15] . The clinical spectrum of SARS-CoV-2 infection varies widely, including asymptomatic infection, mild upper respiratory tract illness, severe viral pneumonia with respiratory failure, and even death [9, 11•] (Fig. 1) . Corticosteroids are recommended in the treatment of septic shock, exacerbation of chronic obstructive respiratory disease and these COVID-19's patients with respiratory deterioration and quick radiological progression associated with sings of cytokine storm (cytopenia, maintained fever, an increase of inflammatory reactants: D-dimer > 1000 ng/mL, ferritin > 1000 ng/mL, fibrinogen > 100 ng/mL, IL-6 > 40 pg/mL) [6, 23••] . Results from 237 patients, 158 assigned to remdesivir, showed no differences in time to clinical improvement, 28day mortality, oxygen support, hospitalization, or viral load. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Effective treatment of severe COVID-19 patients with tocilizumab cache = ./cache/cord-288051-wp8v2mc5.txt txt = ./txt/cord-288051-wp8v2mc5.txt === reduce.pl bib === id = cord-289006-7dv1zsp9 author = Tan, Kimberly-Anne title = Addressing Coronavirus Disease 2019 in Spine Surgery: A Rapid National Consensus Using the Delphi Method via Teleconference date = 2020-05-14 pages = extension = .txt mime = text/plain words = 4529 sentences = 219 flesch = 43 summary = The following topics were discussed: repurposing of surgeons, continuity of spine services, introduction of telemedicine, triaging of spinal surgeries, preoperative testing, new challenges in performing spine surgery, and preparing for the post-pandemic era. The aforementioned challenges in clinical practice brought about by the COVID-19 pandemic raise the question of whether we can use present-day technology to improve patient care. The orthopedic spine service of the National University Hospital has had a long-standing tradition of auditing all upcoming spine surgery cases every week and has reported this to be especially beneficial during the COVID-19 pandemic where resource availability is constantly changing. While the following set of guidelines provide a framework to help spine services triage their patients, the need to continually evaluate the operating lists on a case-by-case and resource-dependent basis remains crucial during this pandemic. cache = ./cache/cord-289006-7dv1zsp9.txt txt = ./txt/cord-289006-7dv1zsp9.txt === reduce.pl bib === id = cord-288697-9dywuhkc author = Noone, Rachel title = LETTER TO THE EDITOR: NEW ONSET PSYCHOSIS AND MANIA FOLLOWING COVID-19 INFECTION date = 2020-08-08 pages = extension = .txt mime = text/plain words = 1312 sentences = 87 flesch = 49 summary = Here we present two case reports of adult patients with COVID-19 infections who presented with severe psychosis and mania with no prior psychiatric history and in the absence of significant medical or pulmonary symptoms and an unremarkable neurological work-up. Clinical presentation: Patient-A presented with one week of insomnia and two days of altered behavior including confusion, decreased appetite, and grandiosity and making odd statements. Three weeks prior to his ED admission, Patient-A was diagnosed with presumed COVID-19, treated with oral azithromycin, and told to self-quarantine. J o u r n a l P r e -p r o o f These cases illustrate an association of neuropsychiatric symptoms with COVID-19 infection, in the absence of personal or family history of psychiatric illness, as well as the absence of hypoxemia, cerebral infarction or significant pulmonary involvement. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic cache = ./cache/cord-288697-9dywuhkc.txt txt = ./txt/cord-288697-9dywuhkc.txt === reduce.pl bib === id = cord-288790-5uzgenty author = Govil, Gaurav title = Rehabilitation of Arthroplasty Patient During Covid-19 date = 2020-05-24 pages = extension = .txt mime = text/plain words = 321 sentences = 27 flesch = 50 summary = key: cord-288790-5uzgenty title: Rehabilitation of Arthroplasty Patient During Covid-19 cord_uid: 5uzgenty The established protocols were sidelined and patients asked to care on their own with dictum being "stay home and stay safe". The majority may respond well to the rehabilitation protocols adopted in pre-Covid era [4] . The induction of patient into an orthopaedic or arthroplasty programme should be a systematic team approach with the inclusion of established patient-specific home-based rehabilitation protocol. Plans that need consideration [3] are: Physical therapy will be even more crucial in the medium to long-term response to assist the orthopaedic and arthroplasty patient to regain optimal function and to help them return to their previous level of activities [3] . Management of orthopaedic patients during COVID-19 pandemic in India: A guide Orthopaedics in times of COVID 19 Total knee arthroplasty rehabilitation protocol: What makes the difference? cache = ./cache/cord-288790-5uzgenty.txt txt = ./txt/cord-288790-5uzgenty.txt === reduce.pl bib === id = cord-288509-l6yn2er7 author = Kalu, Peter title = The rules for online clinical engagement in the COVID era date = 2020-08-22 pages = extension = .txt mime = text/plain words = 3025 sentences = 165 flesch = 49 summary = As a result, even in the absence of a good evidence base, online video consultation platforms such as Attend Anywhere have been implemented across secondary care, with a national licence for NHS trusts from April 2020. 2 In this paper we review current technical, medical and legal guidelines for video consulting to assist hospital doctors who are conducting remote consultations as a result of COVID-19. Although observational studies and randomised control trials of video consultation in primary, secondary and tertiary care generally report a positive patient and clinician experience with remote consultation technology 8, 10, [16] [17] [18] [19] , studies of specific platforms are limited. Evidence regarding the use of telemedicine in secondary care is currently limited but is likely to grow in the post-COVID era as organisations such as the GMC are already conducting surveys of remote consultation and prescribing. cache = ./cache/cord-288509-l6yn2er7.txt txt = ./txt/cord-288509-l6yn2er7.txt === reduce.pl bib === id = cord-289064-435bp4rt author = Muniangi-Muhitu, Hermine title = Covid-19 and Diabetes: A Complex Bidirectional Relationship date = 2020-10-08 pages = extension = .txt mime = text/plain words = 5744 sentences = 290 flesch = 43 summary = Identified risk factors for disease severity and death from SARS-Cov2 infection include older age, male sex, diabetes, obesity and hypertension. We consider roles for the immune system, the observed phenomenon of microangiopathy in severe Covid-19 infection and the potential for direct viral toxicity on metabolically-relevant tissues including pancreatic beta cells and targets of insulin action. (18) , patients with diabetes and hypertension who had been treated with ACE inhibitors or angiotensin receptor blockers (ARB) had a high number of ACE2 receptors in the lung, and could therefore be at higher risk of developing severe symptoms, if infected with Covid-19. With respect to the glycemic deterioration seen in patients with preexisting T2D during Covid-19, a very recent report (63) provides the intriguing observation that ACE2 expression at both the mRNA and protein is increased substantially in human beta cells in response to response to inflammatory cytokines, presumably rendering these cells more susceptible to infection. cache = ./cache/cord-289064-435bp4rt.txt txt = ./txt/cord-289064-435bp4rt.txt === reduce.pl bib === id = cord-289179-3zfur0zh author = Mascarin, Maurizio title = How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients date = 2020-04-11 pages = extension = .txt mime = text/plain words = 543 sentences = 38 flesch = 50 summary = title: How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients According to Liang 1 , as of Jan 31, 2020, based on a cohort of patients in China, 1% of coronavirus disease (COVID-19) cases had a history of cancer. Starting mid-February 2020, we applied these rules for outpatients undergoing radiotherapy: 1) telephonic triage the day before the first admission, and specific clinical triage the day of admission in a dedicated area; 2) daily detailed medical history to detect the possibility of COVID-19 contagion; 3) postponement of non-essential check-ups; 4) medical evaluation or nasopharyngeal swab for patients with rhinitis, conjunctivitis, cough or fever in order to access the hospital; 5) education on hand-washing, no touching mouth, nose, and eyes; 6) couch and mask disinfection after every radiotherapy fraction; 7) compulsory surgical masks for patients, parents and healthcare workers; 8) no volunteers allowed; 9) nasopharyngeal swabs only for people with symptoms or family risk conditions. In most hospitals worldwide, the radiotherapy department is shared by pediatric, adult and elderly patients. cache = ./cache/cord-289179-3zfur0zh.txt txt = ./txt/cord-289179-3zfur0zh.txt === reduce.pl bib === id = cord-288606-h8pmqwmk author = Alhmoud, Eman title = Anticoagulation clinic drive-up service during COVID-19 pandemic in Qatar date = 2020-07-03 pages = extension = .txt mime = text/plain words = 1942 sentences = 90 flesch = 46 summary = Among efforts to safely manage warfarin patients during this pandemic, we introduced a hospital drive-up anticoagulation testing service. Among our efforts to enhance patients' safety and minimize contact time at the healthcare facility while maintaining standard clinical care for warfarin patients, we introduced a hospital drive-up anticoagulation testing service at Al Wakra Hospital (AWH) in Qatar. AWH drive-up anticoagulation testing service was launched in April, 2020 as part of HMC's strategy to stay ahead of the pandemic and to assure patients who expressed concerns about visiting the anticoagulation clinic at AWH due to COVID-19 spread. This service is one of the efforts of healthcare providers to reduce the risk of exposure of anticoagulation patients to COVID-19 by reducing the contact time with the different personnel at the hospital and by maintaining those patients at a safe distance from others. cache = ./cache/cord-288606-h8pmqwmk.txt txt = ./txt/cord-288606-h8pmqwmk.txt === reduce.pl bib === id = cord-288575-srpc68t8 author = Yamakage, Michiaki title = Anesthesia in the times of COVID-19 date = 2020-05-25 pages = extension = .txt mime = text/plain words = 1314 sentences = 74 flesch = 36 summary = As anesthesiologists, our work in operating rooms, emergency departments, and/or intensive care units often brings us in close proximity to the patient's airway, exposing us to their aerosolized respiratory secretions. Wen X and Li Y briefly, but adequately, described anesthesia procedures for emergency surgery in patients with suspected or confirmed COVID-19 in their letter [4] . [25] described the anesthetic management of cardiac surgical patients in their literature; we, could not, however, find any further information regarding this, especially in relation to cardiac anesthesia. Anesthesia procedure of emergency operation for patients with suspected or confirmed COVID-19 Anesthetic management of patients with COVID 19 infections during emergency procedures Anesthesia management and perioperative infection control in patients with the novel coronavirus Recommendations for anesthesia in patients suspected of COVID-19 coronavirus infection Chinese society of anesthesiology expert consensus on anesthetic management of cardiac surgical patients with suspected or confirmed Coronavirus disease 2019 cache = ./cache/cord-288575-srpc68t8.txt txt = ./txt/cord-288575-srpc68t8.txt === reduce.pl bib === id = cord-288810-ab7k70c4 author = Zheng, Yingyan title = Development and Validation of a Prognostic Nomogram Based on Clinical and CT Features for Adverse Outcome Prediction in Patients with COVID-19 date = 2020-06-24 pages = extension = .txt mime = text/plain words = 3369 sentences = 188 flesch = 42 summary = title: Development and Validation of a Prognostic Nomogram Based on Clinical and CT Features for Adverse Outcome Prediction in Patients with COVID-19 OBJECTIVE: The purpose of our study was to investigate the predictive abilities of clinical and computed tomography (CT) features for outcome prediction in patients with coronavirus disease (COVID-19). The prognostic nomogram based on the combination of clinical and CT features could be a useful tool for predicting adverse outcomes of patients with COVID-19. Chest CT manifestations of regional involvement, scattering distribution, transverse distribution, the number of involved https://doi.org/10.3348/kjr.2020.0485 kjronline.org pulmonary segments, extent, shape, ground-glass opacity (GGO), consolidation, crazy-paving sign, halo sign, reversed halo sign (RHS), air bronchogram, bronchiectasis, vascular enlargement, pleural thickening, pleural retraction, pleural effusion, and mediastinal lymphadenopathy were assessed. The nomogram developed using a combination of clinical and CT features could aid in https://doi.org/10.3348/kjr.2020.0485 kjronline.org predicting adverse outcomes for patients with COVID-19. cache = ./cache/cord-288810-ab7k70c4.txt txt = ./txt/cord-288810-ab7k70c4.txt === reduce.pl bib === id = cord-289046-frhpt8n9 author = Fix, Oren K. title = Telemedicine and Telehepatology During the COVID‐19 Pandemic date = 2020-05-21 pages = extension = .txt mime = text/plain words = 1474 sentences = 87 flesch = 51 summary = The Coronavirus Preparedness and Response Supplemental Appropriations Act (H.R. 6074) was signed into law on March 6, 2020, and provides a temporary waiver of many of the CMS restrictions and requirements regarding telemedicine services during the COVID-19 public health emergency. When these barriers to telemedicine were removed, providers, hospitals, and health systems rapidly embraced telemedicine or scaled up existing programs to meet the sudden demand for remote, synchronous patient care. Some patients with new physical symptoms or recent hepatic decompensation are best evaluated in person but may avoid seeking medical care due to social distancing policies or concerns about exposure to COVID-19 in the health care setting. For established patients with decompensated liver disease, review telemedicine can offer rapid evaluation and avoid the need for an in-person appointment when, for example, adjusting diuretics or medications for hepatic encephalopathy. As we look to a future beyond the COVID-19 pandemic, we have an opportunity to consider telemedicine's place in the routine delivery of patient care. cache = ./cache/cord-289046-frhpt8n9.txt txt = ./txt/cord-289046-frhpt8n9.txt === reduce.pl bib === id = cord-288552-7lp07v5i author = Vahedi, Ensieh title = The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study date = 2020-06-19 pages = extension = .txt mime = text/plain words = 4914 sentences = 232 flesch = 40 summary = CONCLUSION: This study revealed the beneficial effect of the short-term use of low-dose prednisolone in combination with azithromycin, naproxen and lopinavir/ritonavir (regimen I), in decreasing ALOS compared to regimen II. Therefore, the present study aimed to evaluate short-term effects of regimen I (azithromycin, prednisolone, naproxen, and lopinavir/ritonavir) in group I patients in comparison to regimen II (meropenem, levofloxacin, vancomycin, hydroxychloroquine, and oseltamivir) in group II patients in the treatment of COVID-19 infection. The patients' medical information including demographic data, COVID-19 test using a real-time RT-PCR via throatswab specimens, clinical features, routine laboratory tests, chest CT scans (before and after discharge) according to the WHO interim guidance [23] , treatment measures, comorbidities and data on the outcomes were extracted independently by two physicians through a standard case record form provided by the hospital. cache = ./cache/cord-288552-7lp07v5i.txt txt = ./txt/cord-288552-7lp07v5i.txt === reduce.pl bib === id = cord-289311-0wgafqdz author = Kim, Jee-Eun title = Neurological Complications during Treatment of Middle East Respiratory Syndrome date = 2017-06-30 pages = extension = .txt mime = text/plain words = 3555 sentences = 209 flesch = 44 summary = Since the first case of Middle East respiratory syndrome (MERS) was reported in Saudi Arabia in 2012, 1,826 laboratory-confirmed cases have been documented in 27 countries, and 35.5% of these patients have died from this novel virus. A triple antiviral treatment regimen comprising subcutaneous pegylated interferon alpha-2a (180 µg per week for 2 weeks), high-dose oral ribavirin [2,000 mg loading dose, followed by 1,200 mg every 8 h (q8h) for 4 days and then 600 mg q8h for 4-6 days], and oral lopinavir/ritonavir (400 mg/100 mg q12h for 10 days) was administered to all patients regardless of disease severity, which was in accordance with the interim recommendations generated during the early period of the Korean MERS epidemic. 10 GI: gastrointestinal, HFNC: high-flow nasal cannula oxygen therapy, IFN: type 1 interferon, IVIG: intravenous immunoglobulin, LR: lopinavir/ritonavir, MERS: Middle East respiratory syndrome, PSI: Pneumonia Severity Index, Rb: ribavirin, SAPS II: Simplified Acute Physiology Score II. cache = ./cache/cord-289311-0wgafqdz.txt txt = ./txt/cord-289311-0wgafqdz.txt === reduce.pl bib === id = cord-289542-u86ujtur author = Razavian, Narges title = A validated, real-time prediction model for favorable outcomes in hospitalized COVID-19 patients date = 2020-10-06 pages = extension = .txt mime = text/plain words = 8068 sentences = 379 flesch = 45 summary = Here, we use 3345 retrospective and 474 prospective hospitalizations to develop and validate a parsimonious model to identify patients with favorable outcomes within 96 h of a prediction, based on real-time lab values, vital signs, and oxygen support variables. In this article, we describe how a collaboration among data scientists, electronic health record (EHR) programmers (vendorand health system-based), clinical informaticians, frontline physicians, and clinical leadership led to the development, prospective validation, and implementation of a machine learning model for real-time prediction of favorable outcomes within a 96 h window among hospitalized COVID-19 patients. Our approach differs from prior work in that we: (1) predict favorable outcomes (as opposed to adverse outcomes), (2) use a large COVID-19 patient cohort admitted across our hospitals, (3) design a model that can easily be extended to other institutions, (4) prospectively validate performance, and (5) integrate our model in the EHR to provide a real-time clinical decision support tool. cache = ./cache/cord-289542-u86ujtur.txt txt = ./txt/cord-289542-u86ujtur.txt === reduce.pl bib === id = cord-289054-fh95b5n4 author = Au Yong, Phui S. title = Reducing droplet spread during airway manipulation: lessons from the COVID-19 pandemic in Singapore date = 2020-04-15 pages = extension = .txt mime = text/plain words = 1181 sentences = 77 flesch = 53 summary = E-mail: angie.au.yong.p.s@singhealth.com.sg Keywords: airway management; COVID-19; extubation; infection control; intubation; operating room; prevention EditordCoronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization 1 on March 11, 2020 because of its rapid worldwide spread. 2 Airway manipulation poses a high risk of viral transmission to humans within close contact because of the proximity of the respiratory secretions that can aerosolise from coughing and gagging. The Singapore General Hospital instituted guidelines for airborne and contact precautions, including (i) environmental, reducing staff during airway manipulation, regular disinfection and sterilisation, sufficient air exchange time; and (ii) personal protective equipment (PPE). The main aim of constructing a tent or screen is that, if the patient coughs/gags during intubation, secretions will land under the sheet. A videolaryngoscope and tracheal tube can be passed under the plastic tent for intubation. Alternatively, Supplementary Fig 4 shows the use of a large plastic screen for intubation. cache = ./cache/cord-289054-fh95b5n4.txt txt = ./txt/cord-289054-fh95b5n4.txt === reduce.pl bib === id = cord-289457-06gwrpu0 author = Berth, Sarah H. title = Secondary Causes of Myositis date = 2020-10-06 pages = extension = .txt mime = text/plain words = 3811 sentences = 233 flesch = 29 summary = The term "myositis" is often used interchangeably with "idiopathic inflammatory myopathy" (IIM), referring to primary autoimmune diseases of muscle including dermatomyositis, inclusion body myositis (IBM), antisynthetase syndrome, and necrotizing autoimmune myopathy [1] [2] [3] [4] [5] [6] . Another case series of three patients with dermatomyositis-associated cGVHD showed improvement with immunosuppression via combination treatment of corticosteroids, tacrolimus, rituximab, mycophenolate mofetil, and/or IVIG [43] . Patients with polymyositis or dermatomyositis that underwent intensive aerobic exercise combined with resistance training in a randomized controlled trial have improved muscle function, quality of life, and possible reduced disease activity [89] . A pilot study of 20 patients with refractory dermatomyositis or polymyositis using abatacept found that almost half of their patients showed reduced disease activity and improved muscle performance after treatment for 6 months [98] , and there is now a phase III, randomized, double-blind trial to further evaluate abatacept for myositis treatment (ClinicalTrials.gov identifier: NCT02971683). cache = ./cache/cord-289457-06gwrpu0.txt txt = ./txt/cord-289457-06gwrpu0.txt === reduce.pl bib === id = cord-289115-bntcn0m6 author = Thangaraju, Pugazhenthan title = Role of Dupilumab in Approved Indications of COVID-19 Patient: an Efficacy-Based Nonsystematic Critical Analysis date = 2020-09-10 pages = extension = .txt mime = text/plain words = 2136 sentences = 110 flesch = 49 summary = There are isolated case reports and series that document a milder course of COVID-19 infection in patients who have already been on dupilumab therapy for treatment of conditions such as atopic dermatitis and chronic rhino-sinusitis with nasal polyp. While it has already been in use in dermatology clinics for the treatment of atopic dermatitis (AD), it was most recently approved for the indication of chronic rhinosinusitis with nasal polyp (CRSwNP) by the US Food and Drug Association (FDA) on the 26th of June, 2019 [1] . We included clinical trials, research studies, case reports, and randomized control trials that employed the use of dupilumab at any point in the treatment of patients who were laboratory confirmed cases of COVID19. Details that were extracted included author and journal details, year of publication, sample size, age, sex, indication for rational use of dupilumab, duration for treatment, adverse effects observed, and course of COVID-19 infection. COVID-19 infection in a patient with severe chronic rhinosinusitis with nasal polyps during therapy with dupilumab cache = ./cache/cord-289115-bntcn0m6.txt txt = ./txt/cord-289115-bntcn0m6.txt === reduce.pl bib === id = cord-289219-qjxdggz3 author = Sebio-García, Raquel title = Pulmonary Rehabilitation: Time for an Upgrade date = 2020-08-25 pages = extension = .txt mime = text/plain words = 1866 sentences = 78 flesch = 37 summary = Pulmonary rehabilitation is a notoriously known but highly underused intervention aimed to restore or improve functional capacity, symptom management and health-related quality of life among patients with chronic respiratory diseases. Since early 1980s, pulmonary rehabilitation has been acknowledged as a comprehensive intervention with hundreds of studies being performed over the past thirty years demonstrating its benefits on multiple outcomes; nevertheless, there are still multiple unresolved challenges, and new ones are currently emerging, with the COVID-19 outbreak now in the spotlight. PR stems from a comprehensive evaluation of the patient aimed to design an individually-tailored, multi-component intervention to optimise symptom control, pulmonary function, exercise capacity and health-related quality of life [1] . The effectiveness of PR on different outcomes such as exercise capacity, muscle function, dyspnoea and symptom control, is quite robust, so it is currently recommended in the management of different chronic respiratory conditions, especially for patients with chronic obstructive pulmonary disease (COPD). cache = ./cache/cord-289219-qjxdggz3.txt txt = ./txt/cord-289219-qjxdggz3.txt === reduce.pl bib === id = cord-289690-af6lsj1g author = Svobodova, Tamara title = Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date = 2015-02-10 pages = extension = .txt mime = text/plain words = 3546 sentences = 211 flesch = 39 summary = BACKGROUND: GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. CONCLUSION: We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic celland B-lymphopenia, irrespective of severity of the clinical phenotype. Defects of transcription factor GATA-2 have recently been identified in a few overlapping phenotypes associated with myeloid malignancies: dendritic cell, monocyte, B-and NK-cell deficiency; MonoMAC syndrome (monocytopenia with Mycobacterium avium complex infections); Emberger syndrome (early onset primary lymphedema, multiple warts, sensorineural deafness, dysmorphism); and familial MDS/AML with no additional known phenotype. We present an adolescent male with GATA-2 deficiency and early manifestation of diffuse parenchymal lung disease (DPLD) as well as an atypical course of Epstein-Barr virus (EBV) infection. cache = ./cache/cord-289690-af6lsj1g.txt txt = ./txt/cord-289690-af6lsj1g.txt === reduce.pl bib === id = cord-289719-64ugdvfe author = Tenforde, Mark W. title = Characteristics of Adult Outpatients and Inpatients with COVID-19 — 11 Academic Medical Centers, United States, March–May 2020 date = 2020-07-03 pages = extension = .txt mime = text/plain words = 3166 sentences = 148 flesch = 46 summary = During April 15-May 24, 2020, telephone interviews were conducted with a random sample of adults aged ≥18 years who had positive reverse transcription-polymerase chain reaction (RT-PCR) test results for SARS-CoV-2 in outpatient and inpatient settings at 11 U.S. academic medical centers in nine states. During April 15-May 24, 2020, telephone interviews were conducted with a random sample of adults aged ≥18 years who had positive reverse transcription-polymerase chain reaction (RT-PCR) test results for SARS-CoV-2 in outpatient and inpatient settings at 11 U.S. academic medical centers in nine states. To explore the spectrum of illness across health care settings and potential community SARS-CoV-2 exposures after issuance of national social distancing guidelines on March 16, 2020 (4), 11 academic medical centers in nine states conducted telephone-based surveys of a sample of patients with positive SARS-COV-2 test results during April 15-May 24, 2020 (testing dates = March 31-May 10, 2020). cache = ./cache/cord-289719-64ugdvfe.txt txt = ./txt/cord-289719-64ugdvfe.txt === reduce.pl bib === id = cord-289088-7uoia564 author = Ding, Qiang title = The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China date = 2020-03-30 pages = extension = .txt mime = text/plain words = 1517 sentences = 88 flesch = 49 summary = title: The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China In conclusion, those patients with both COVID‐19 and influenza virus infection did not appear to show a more severe condition because based on the laboratory findings, imaging studies, and patient prognosis, they showed similar clinical characteristics as those patients with COVID‐19 infection only. In this study, we describe the clinical characteristics of those patients who got infected with COVID-19 as well as influenza virus. On one hand, this study showed that the clinical characteristics of patients with both COVID-19 and influenza virus infection were similar to those of COVID-19 infection, but the symptoms of nasal tampon and pharyngalgia may be more prone to appear, which would be more convinced when more cases included. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China cache = ./cache/cord-289088-7uoia564.txt txt = ./txt/cord-289088-7uoia564.txt === reduce.pl bib === id = cord-289322-5ciaonf0 author = Chen, X. title = Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study date = 2020-03-06 pages = extension = .txt mime = text/plain words = 3871 sentences = 239 flesch = 56 summary = title: Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study Methods: In this double-center, observational study, we recruited all consecutive patients with laboratory confirmed COVID-19 from January 23 to February 14, 2020 in two designated hospitals in Hunan province, China. Epidemiological and clinical data from patients' electronic medical records were collected and compared between mild, moderate and severe/critical group in detail. Our study also showed the proportion of patients who had been to Wuhan in severe/critical group (48.0%) and moderate group (43.4%) were higher than mild group (17.2%). 77.6% patients with available coagulation function test result had elevated fibrinogen on admission, and the proportion in severe/critical group was even higher, which have not been observed in other studies. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study cache = ./cache/cord-289322-5ciaonf0.txt txt = ./txt/cord-289322-5ciaonf0.txt === reduce.pl bib === id = cord-289008-c4cu3vrp author = Wallis, Christopher J.D. title = Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic date = 2020-05-03 pages = extension = .txt mime = text/plain words = 9353 sentences = 446 flesch = 44 summary = Patients with muscle-invasive bladder cancer are at risk of disease progression, with radical cystectomy delays beyond 12 wk from diagnosis or completion of neoadjuvant chemotherapy. To this end, PubMed was searched from inception until April 2, 2020 to identify studies examining the association between delays in treatment and clinical outcomes, including upstaging, recurrence, and mortality for patients with bladder cancer (BC; both muscle-invasive and non-muscle-invasive disease), prostate cancer (PCa), kidney cancer, upper tract urothelial cancer, germ cell tumors, and penile cancer. Where radiotherapy is planned to be administered, a recent Cochrane Database systematic review and meta-analysis of 10 studies including 8278 patients demonstrated that for those with intermediate-and high-risk PCa, hypofractionation is associated with equivalent oncologic outcomes (MFS, disease-specific survival, and OS), as well as functional outcomes [64] . cache = ./cache/cord-289008-c4cu3vrp.txt txt = ./txt/cord-289008-c4cu3vrp.txt === reduce.pl bib === id = cord-290006-63sa00ju author = Ko, Jane P. title = Approach to Peribronchovascular Disease on CT date = 2018-12-20 pages = extension = .txt mime = text/plain words = 6389 sentences = 453 flesch = 37 summary = 14 Other lymphoproliferative disorders affecting the lung and pleura also include nodular lymphoid hyperplasia and Castleman's disease, which lack monoclonal proliferation, in addition to primary effusion lymphoma that affects pleural, pericardial, or peritoneal spaces in immunocompromised individuals such as with acquired immune deficiency syndrome (AIDS). 43 Subsequently, a number of etiologies known to cause a reversed-halo sign and include infection such as zygomycosis, invasive apergillosis, tuberculosis, histoplasmosis, cryptococcosis, Pneumocystis jirovecii pneumonia, paracoccidioidomycosis; infarct from pulmonary embolism; eosinophilic processes; post-lung ablation and stereotactic body radiation therapy changes; lung adenocarcinomas; granulomatosis with polyangiitis; lymphoproliferative disorders; and sarcoidosis. Aspergillus infection affects immunocompromised patients, such as those on steroids, leukemia, and after bone marrow and organ transplantation, often in the form of angioinvasive aspergillosis (ANG), although airway invasive aspergillus (AIA) is another manifestation that is associated with peribronchial opacities. Viral infections affect the lung interstitum and present on CT with centrilobular nodules, ground-glass opacity, consolidation, and bronchial wall thickening (Fig. 7) . cache = ./cache/cord-290006-63sa00ju.txt txt = ./txt/cord-290006-63sa00ju.txt === reduce.pl bib === id = cord-289574-engwi8h3 author = An, Peng-jiao title = Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications date = 2020-05-23 pages = extension = .txt mime = text/plain words = 3188 sentences = 220 flesch = 39 summary = Accumulating evidence suggested that the progression of COVID-19 is associated with lymphopenia and excessive inflammation, and a subset of severe cases might exhibit cytokine storm triggered by secondary hemophagocytic lymphohistiocytosis (sHLH). Previously, it has been found that the serum levels of pro-inflammatory cytokines [IFN-γ, IL-1, IL-6, IL-12, and transforming growth factor-β (TGF-β)], and chemokines (CCL2, CXCL9, CXCL10, and IL-8) in SARS-CoV infected patients were higher than those in healthy individuals. Procalcitonin (PCT), released by bacterial infectious tissues under the irritation of pro-inflammatory cytokines, is a more specific marker of serious bacterial infection compared to C-reactive protein (CRP) and IL-6 [111] PCT-based strategy has been applied to guide antibiotic use in ICU or emergency wards, since the serum PCT levels in patients with severe bacterial infections are much higher than those with simple viral infections or non-specific inflammatory diseases [111] [112] [113] . The definition and risks of Cytokine Release Syndrome-Like in 11 COVID-19-Infected Pneumonia critically ill patients: Disease Characteristics and Retrospective Analysis cache = ./cache/cord-289574-engwi8h3.txt txt = ./txt/cord-289574-engwi8h3.txt === reduce.pl bib === id = cord-289581-aozg3o9o author = nan title = Abstracts der 54. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date = 2016-08-25 pages = extension = .txt mime = text/plain words = 16405 sentences = 1905 flesch = 54 summary = Daher geht eine erhöhte Neutrophile/Lymphozyten Ratio (NLR) mit einem ungünstigen kardiometabolischen Profil einher und konnte bereits als Marker für kardiovaskuläre Erkrankungen im Erwachsenenalter bei Pa-tientInnen ohne Diabetes mellitus herangezogen werden. Ziel: Wir bestimmten den zeitlichen Verlauf der Symptome während und bis zu 9 Stunden nach dem Fruktosetest bei Kindern die sensitiv auf Fruktose reagierten. 60 konsekutive Patienten (Alter: 10-15 Jahre; 28 männlich, 33 weiblich) mit chronisch abdominellen Beschwerden erhielten einen Fruktose H2-Atemtest zur Abklärung des Verdachts auf Kohlenhydratmalabsorption; eine 20 % Fruktoselösung wurde dafür verabreicht, 1 g/kg Körpergewicht bis zu maximal 25 g.Die Diagnose einer Fruktosemalabsorption wurde gestellt, wenn der Anstieg der H2-Atemluftkonzentration über 20 ppm betrug. Nach HDMTX-Gabe zeigten sich in der untersuchten Kohorte breit gestreute und großteils signifikante Blutbildveränderungen, welche jedoch zusätzlich durch die protokollgemäße, gleichzeitige Gabe von Purinethol (6-Mercaptopurin) (mit-)verursacht sein können. Wir berichten von einem 5-jährigen Mädchen bei dem aufgrund erheblicher therapieassoziierter Toxizität im Rahmen der Therapie eines Medulloblastoms die Erstdiagnose einer Ataxia teleangiectasia vor Auftreten charakteristischer Stigmata gestellt wurde. cache = ./cache/cord-289581-aozg3o9o.txt txt = ./txt/cord-289581-aozg3o9o.txt === reduce.pl bib === id = cord-289169-3u7qgxud author = Fang, Xiaowei title = Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 date = 2020-04-11 pages = extension = .txt mime = text/plain words = 494 sentences = 42 flesch = 52 summary = title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 In the present study, all patients were from a single center, and all swab samples were tested using a unified approach at the Chinese Center for Disease Control to avoid measurement bias. In fact, a similar study analyzing data from 72 patients with COVID-19 was conducted at the First Affiliated Hospital of Zhejiang University, and the conclusions were consistent with the results of the present study (7) . In conclusion, low-dose corticosteroid therapy may not delay viral clearance in patients with COVID-19; however, this still needs to be confirmed by well-designed and large-scale Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome Retrospective study of low-to-moderate dose glucocorticoids on viral clearance in patients with novel coronavirus pneumonia cache = ./cache/cord-289169-3u7qgxud.txt txt = ./txt/cord-289169-3u7qgxud.txt === reduce.pl bib === id = cord-289816-rlwoy8ms author = Tedeschi, Delio title = Acute myocardial infarction and large coronary thrombosis in a patient with COVID‐19 date = 2020-08-07 pages = extension = .txt mime = text/plain words = 1450 sentences = 74 flesch = 41 summary = This is a case report of a 60‐year‐old male, without any cardiovascular risk factor and no cardiac history admitted to hospital with a diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID‐19). Due to high levels of proinflammatory mediators, diffuse coronary thrombosis could occur even in patients without cardiac history or comorbidities. This clinical case suggests that coronary thrombosis in COVID‐19 patients may be unresponsive to optimal pharmacological (GP IIb–IIIa infusion) and mechanical treatment (PCI). The chest X-ray revealed evidence of pneumonia with bilateral multiple interstitial ill-defined patchy opacities ( When admitted, the patient was treated with dexamethasone (12 mg iv), hydroxychloroquine (200 mg twice daily), antiviral drugs (lopinavir/ritonavir-2 tablets 200/50 mg twice daily), oxygen support (Venturi mask FiO2 40%), antibiotic prophylaxis with ceftriaxone (2 g iv), and venous thromboembolic (VTE) prophylaxis with enoxaparin (4,000 U.I. sc). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China cache = ./cache/cord-289816-rlwoy8ms.txt txt = ./txt/cord-289816-rlwoy8ms.txt === reduce.pl bib === id = cord-289859-b1k9uyp6 author = Hodges, Kevin title = Successful management of COVID‐19 and associated coagulopathy in a patient with durable left ventricular assist device date = 2020-08-13 pages = extension = .txt mime = text/plain words = 1055 sentences = 63 flesch = 38 summary = title: Successful management of COVID‐19 and associated coagulopathy in a patient with durable left ventricular assist device Patients with durable left ventricular assist devices pose special problems for management in the setting of COVID‐19 infection. We describe the successful management of a 44‐year‐old man with severe COVID‐19 infection and HeartMate 3 left ventricular assist device. Patients with durable left ventricular devices (LVADs) pose special problems for management in the setting of COVID-19 infection. [1] [2] [3] We present the case of a patient with ischemic cardiomyopathy supported by durable LVAD who developed severe COVID-19 infection with acute respiratory distress syndrome complicated by coagulopathy. Management of COVID-19 infection in the context of durable LVAD support requires careful institutional planning and a multidisciplinary approach. Successful management of COVID-19 and associated coagulopathy in a patient with durable left ventricular assist device cache = ./cache/cord-289859-b1k9uyp6.txt txt = ./txt/cord-289859-b1k9uyp6.txt === reduce.pl bib === id = cord-289553-gygvhzcc author = Alvarez, Roger A. title = Home Nitric Oxide Therapy for COVID-19 date = 2020-07-01 pages = extension = .txt mime = text/plain words = 1825 sentences = 89 flesch = 43 summary = 130-132) present an interesting and compelling case of a patient with pulmonary arterial hypertension (PAH) who was treated remotely in an ambulatory setting with inhaled nitric oxide (iNO) (5) . In a randomized and placebo-controlled trial of ambulatory patients with fibrotic lung disease requiring long-term oxygen, INOpulse therapy was associated with greater physical activity than placebo, and in an acute dose escalation study of patients with pulmonary hypertension associated with pulmonary fibrosis, iNO delivered through the INOpulse system lead to a 30% reduction in pulmonary vascular resistance, with improvements in Q _ and pulmonary artery compliance (15) . The Hestia criteria identified a cohort of patients with acute PE who completed outpatient therapy with a low risk of adverse events, including recurrent venous thromboembolism (2%), all-cause mortality (1%), and major bleeding (0.7%). cache = ./cache/cord-289553-gygvhzcc.txt txt = ./txt/cord-289553-gygvhzcc.txt === reduce.pl bib === id = cord-289930-7xm6q68s author = Li, Yang title = Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational study date = 2020-08-21 pages = extension = .txt mime = text/plain words = 4331 sentences = 199 flesch = 42 summary = In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation, namely, the therapeutic window. According to the currently known molecular mechanisms and pathophysiology data on severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS), and influenza patients, critically ill patients usually undergo the following stages: virus invasion, immune activation, excessive inflammatory response, acute respiratory distress syndrome (ARDS), and, in the end, possible recovery or death [6] [7] [8] [9] [10] [11] . Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids could benefit patients with LDH levels of less than two times ULN, who may be in the early phase of excessive inflammation. Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids could benefit patients with LDH levels of less than two times ULN, who may be in the early phase of excessive inflammation. cache = ./cache/cord-289930-7xm6q68s.txt txt = ./txt/cord-289930-7xm6q68s.txt === reduce.pl bib === id = cord-289114-ifnk41oq author = Singh, Angaraj title = Effect of pre‐existing diseases on COVID‐19 infection and role of new sensors and biomaterials for its detection and treatment date = 2020-10-28 pages = extension = .txt mime = text/plain words = 6894 sentences = 470 flesch = 54 summary = The SARS-CoV-2 infected patients with the cardiovascular problem have a higher fatality rate as compared to general COVID-19 patients. The ACE-2 has been suggested as a medicine for the treatment of diabetes because it reduces inflammation .Therefore, the diabetes and COVID-19 patients treated with ACE-2 have higher risk of infection (Zachary, 2020) . Although, the specific drug for SARS-CoV-2 is not discovered till date, the medical observers are attempting with different antiviral drugs for the treatment of COVID-19 infection . All rights reserved patients demonstrated that the combination of a new antiviral drug remdesivir and chloroquine slowed down the growth of SARS-CoV-2 (Abdul et al., 2017) . Convalescent plasma therapy has been observed as a better alternative for the treatment of severely infected COVID-19 patients. A research report suggested that plasma treatment is more effective at the initial stage (within 14 days of symptoms) of COVID-19 infection. cache = ./cache/cord-289114-ifnk41oq.txt txt = ./txt/cord-289114-ifnk41oq.txt === reduce.pl bib === id = cord-289533-hip9qtu5 author = Smulever, Anabella title = Thyroid cancer in the Era of COVID-19 date = 2020-08-04 pages = extension = .txt mime = text/plain words = 2822 sentences = 130 flesch = 41 summary = Since this disease is considered an immunosuppressive status by itself, especially in some types of cancer, the medical community has become increasingly concerned about the potentially deleterious effects that COVID-19 infection may cause in these patients. However, the limited current medical evidence suggests that there is no reason to believe that merely a history of thyroid cancer is enough to have an increased risk of developing COVID-19 infection or to evolve into a poor outcome. The frequency and modality of surveillance for patients with thyroid cancer in the COVID-19 pandemic must be adapted according to the risk of recurrence and the response to treatment. Patients with an excellent, indeterminate, or biochemical incomplete response to treatment do not constitute a risk group for COVID-19 infection, and the frequency of structural disease is less than 4%, 15%, and 20%, respectively [14] . cache = ./cache/cord-289533-hip9qtu5.txt txt = ./txt/cord-289533-hip9qtu5.txt === reduce.pl bib === id = cord-289854-p8okfa4b author = Flores, Gabriel title = Spontaneous Brainstem Hemorrhagic Stroke in the Setting of Novel Coronavirus Disease 2019 – A Case Report date = 2020-10-05 pages = extension = .txt mime = text/plain words = 1422 sentences = 90 flesch = 44 summary = In this report, we outline the clinical presentation of a 40-year-old male who developed severe coughing and sneezing before presenting to the emergency department with confusion, somnolence, and respiratory distress. On hospital day four, his neurological examination deteriorated to quadriparesis and only cough and gag reflexes remaining intact after which his family opted for comfort measures only. Since initial reports in December 2019 from Wuhan, China, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus two (SARS-CoV-2) has become a global pandemic. Our patient is a 40-year-old male with past medical history of obesity, hypertension, and type two diabetes mellitus who developed severe coughing and sneezing before presenting to the emergency department with confusion, somnolence, and respiratory distress. Severe cough was reported to cause cerebral hemorrhage in patients with whooping cough as early as 1885 [8] . Increased risk of intracerebral hemorrhage adds to the complexity of management of patients with COVID-19. cache = ./cache/cord-289854-p8okfa4b.txt txt = ./txt/cord-289854-p8okfa4b.txt === reduce.pl bib === id = cord-289806-6ihptx6n author = Martinez, Rebecca title = Critical Obstetric Patients During the Coronavirus Disease 2019 Pandemic: Operationalizing an Obstetric Intensive Care Unit date = 2020-10-07 pages = extension = .txt mime = text/plain words = 3186 sentences = 155 flesch = 39 summary = The pandemic brought near-complete cessation of nonurgent hospital activities with the rapid expansion of critical care services, with the notable exception of the labor and delivery unit (LDU), which continued to have a full complement of patients presenting for obstetric care. By the time the obstetric ICU (OBICU) was fully operational (end of March), the volume demand was mildly curtailed by some patients electing to leave NYC; however, interinstitutional transfers for maternal or fetal indications provided steady demands for care, with fluctuations occurring week by week. However, a key difference is that the critical care attendings (ICU oversight) are not ultimately responsible for patient care decisions and provide ad hoc consultations if deemed needed by the obstetric anesthesia attending. Daily online lectures by the Internal Medicine or Anesthesia departments review critical care topics that are both general in nature and specific to SARS-CoV-2 infection; these lectures while targeted at residents were available to all members of the OBICU team. cache = ./cache/cord-289806-6ihptx6n.txt txt = ./txt/cord-289806-6ihptx6n.txt === reduce.pl bib === id = cord-289775-40bi87iz author = Haines, David E. title = Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety date = 2014-05-07 pages = extension = .txt mime = text/plain words = 28535 sentences = 1331 flesch = 35 summary = The specific criteria for recredentialing are determined by each individual hospital, but should generally parallel the following recommendations: ABIM CCEP board certification and IBHRE certification are limited to 10 years; to stay current for CCEP, the physician must complete a series of CME and/or practice improvement activities 9 ; recertification examination for CCEP and CCDS are each required at 10-year intervals; to ensure that cognitive and technical skills are maintained, the physician's clinical competence must be evaluated and documented on a regular basis; it is the responsibility of the medical staff credentialing committee to ensure that physicians perform the necessary number of evaluations and procedures needed to maintain their expertise 31 and also that they participate in regular CME activities. The procedure report should include, at minimum, all the following: the primary and secondary operators, the indication for the procedure, names and doses of any medications administered, catheter/pacing/ICD lead model and serial numbers, insertion sites and intracardiac destinations, findings and procedure performed, complications encountered, and fluoroscopic exposure (fluoroscopy time, radiation dose, and the dose-area product) by an Advanced Cardiac Life Support (ACLS)/Pediatric Advanced Life Support (PALS)-certified nurse. cache = ./cache/cord-289775-40bi87iz.txt txt = ./txt/cord-289775-40bi87iz.txt === reduce.pl bib === id = cord-289828-3k088z9n author = De Salvo, Andrea title = How to be together and carry on our project activities during COVID‐19 pandemic in Rome date = 2020-08-03 pages = extension = .txt mime = text/plain words = 1052 sentences = 58 flesch = 59 summary = [3] [4] [5] In the last few years, numerous initiatives and dedicated programs were developed worldwide with the aim to help these patients to deal with diagnosis and treatments, and also to allow them to imagine, dream, design, learn, and maintain relationships with their peers in and outside the hospital walls. AYA with cancer are more vulnerable to experience high levels of fear and Play4You gave them a coping strategy based on game sharing. The aim of this report was to share with the community that takes care of AYAs; this model is able to reach and help more patients at home, in hospital or elsewhere, simply by using relatively old tools such as Internet connection, individuals' smartphones, and selected RPGs. Psychosocial dimensions of cancer in adolescents and young adults The experience of loneliness among young adult cancer patients Health and supportive care needs of young adult cancer patients and survivors cache = ./cache/cord-289828-3k088z9n.txt txt = ./txt/cord-289828-3k088z9n.txt === reduce.pl bib === id = cord-290041-zxlq63n5 author = Srivastava, Arnav title = Delaying Surgery for Clinical T1b-T2bN0M0 Renal Cell Carcinoma: Oncologic Implications in the COVID-19 Era and Beyond date = 2020-10-20 pages = extension = .txt mime = text/plain words = 2992 sentences = 184 flesch = 50 summary = MATERIALS AND METHODS: We retrospectively abstracted cT1b-T2bN0M0 RCC patients from the National Cancer Database (NCDB), stratifying them by clinical stage and time from diagnosis to surgery. 1 These delayed surgeries include many potentially curative urologic oncologic surgeries 2, 3 , such as partial and radical nephrectomies for renal cell carcinoma (RCC), which remain the preferred curative treatment for localized kidney cancer. Our retrospective analysis using the NCDB is the largest study to date to examine the risks of surgical delay on up-staging and OS in cT1b-T2b RCC. 16 Additionally, our grouping points of <1 month, 1-3 months, >3 months were selected based on prior literature and our clinical practice during the COVID-19 pandemic where local institutions delayed most kidney cancer cases by 1-3 months. In most patients with clinically localized cT1b tumors, surgery may be safely delayed for up to 6 months without significant sacrifices in overall survival. Impact of Time-To-Surgery and Surgical Delay on Oncologic Outcomes for Renal Cell Carcinoma cache = ./cache/cord-290041-zxlq63n5.txt txt = ./txt/cord-290041-zxlq63n5.txt === reduce.pl bib === id = cord-290028-oyd7vzj6 author = Unruh, Mark title = Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis date = 2020-10-20 pages = extension = .txt mime = text/plain words = 7668 sentences = 339 flesch = 45 summary = This will be accomplished with a randomized controlled trial (RCT) in which 126 participants treated with HD in community-based dialysis facilities with chronic insomnia will be assigned 1:1:1 to telehealth CBT-I, trazodone, or medication placebo, respectively; short-term effectiveness of each treatment arm will be determined at the end of 6-weeks of treatment and long-term effectiveness at 25-weeks. Study design and overview SLEEP-HD is a parallel-group RCT wherein 126 HD patients treated in community-based dialysis facilities in Seattle and Albuquerque will be randomized 1:1:1 over 31 months to 6-week treatment with telehealth Cognitive Behavioral Therapy for Insomnia (CBT-I), trazodone, or medication placebo (Fig. 1) . cache = ./cache/cord-290028-oyd7vzj6.txt txt = ./txt/cord-290028-oyd7vzj6.txt === reduce.pl bib === id = cord-289612-4x5t4c5u author = Alsuliman, Tamim title = COVID-19 paraclinical diagnostic tools: Updates and future trends date = 2020-06-20 pages = extension = .txt mime = text/plain words = 7353 sentences = 387 flesch = 48 summary = Laboratory-confirmed SARS-CoV-2 infection requires the detection of viral nucleic acid in respiratory tract samples by the use of real-time reverse-transcription polymerase chain reaction (rRT-PCR) assay. In the course of this phase, upper respiratory specimens were tested by RT-PCR for viral RNA and the majority of the patients showed positive results for SARS-CoV-2. These results contrast with another German smaller study by Wolfel et al., conducted on 9 COVID-19 patients, with no discernible difference in viral loads or detection rates when comparing nasal and throat swabs [38] . found that 66.67% of laboratory-confirmed COVID-19 patients were tested positive for SARS-CoV-2 RNA in stool specimens. enrolled a total of 173 confirmed cases of COVID-19 by the use of rRT-PCR on samples from the respiratory track reported that the seroconversion sequentially appeared for the total antibody (Ab), IgM and then IgG, with a median time of 11, 12 and 14 days, respectively. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases cache = ./cache/cord-289612-4x5t4c5u.txt txt = ./txt/cord-289612-4x5t4c5u.txt === reduce.pl bib === id = cord-290081-pjg00t7g author = Dunkerley, Sarah title = Patient care modifications and hospital regulations during the COVID-19 crisis created inequality and functional hazard for patients with orthopaedic trauma date = 2020-08-07 pages = extension = .txt mime = text/plain words = 2921 sentences = 183 flesch = 56 summary = PURPOSE: The COVID pandemic has decreased orthopaedic fracture operative intervention and follow-up and increased the use of virtual telemedicine clinics. We surveyed 100 virtual fracture clinic follow-up patients for satisfaction, time off work and travel. New virtual follow-up fracture clinics reduced patient face-to-face appointments. All the patients brought into hospital were 'normal' decisions and all those in the virtual fracture clinic review clinic were 'COVID' due to lack of normal face-to-face interaction. The PIFU patients were subdivided into 3 groups: 'normal' decisions, 'COVID' decisions based on lack of clinical review or follow-up, and 'COVID' decisions based on potential mal-unions (see Fig. 1 ). Of the 11 patients who were brought back for a face-to-face follow-up, five were due to future appointments to have a cast removed and six were due to the clinician deciding they needed a clinical assessment in hospital (thus a repeat appointment). cache = ./cache/cord-290081-pjg00t7g.txt txt = ./txt/cord-290081-pjg00t7g.txt === reduce.pl bib === id = cord-289973-1mczuxsy author = Biran, Noa title = Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study date = 2020-08-14 pages = extension = .txt mime = text/plain words = 5218 sentences = 271 flesch = 41 summary = 14 Understanding the limitations of observational studies, but with the urgency to assess potential therapeutic approaches, the 13 hospitals within the Hackensack Meridian Health network (NJ, USA) considered offlabel use of tocilizumab in patients with severe SARSCoV2 infection who required intensive care unit (ICU) support. Adjusted Cox proportional hazards regression models were fitted to estimate the associ ation between tocilizumab use and overall survival, using clini cally likely confounders including age, gender, diabetes, chronic obstructive pulmonary disease (COPD) or asthma, hypertension, cancer, renal failure, obesity, oxygena tion less than 94%, quick Sequential Organ Failure Assessment (qSOFA) score, use of steroids, Creactive protein 15 mg/dL or higher, and intubation or mech anical ven tilator support. Propensity score-matched patients (n=630)* First, we calculated a propensity score of receiv ing tocilizumab treatment for each patient using multi variable logistic regression with the confounders age, gender, diabetes, COPD or asthma, hypertension, cancer, renal failure, obesity, oxygenation less than 94%, qSOFA score, use of steroids, Creactive protein 15 mg/dL or higher, and intubation or mechanical ventilator support. cache = ./cache/cord-289973-1mczuxsy.txt txt = ./txt/cord-289973-1mczuxsy.txt === reduce.pl bib === id = cord-290200-csmisulw author = Friedlaender, Alex title = Rethinking the Optimal Duration of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer Throughout the COVID-19 Pandemic date = 2020-05-12 pages = extension = .txt mime = text/plain words = 4022 sentences = 189 flesch = 50 summary = Immune checkpoint inhibitors (ICPIs) have revolutionized the management and prognosis of fit patients with advanced non-small cell lung cancer (NSCLC). In the OAK trial, assessing the efficacy of the anti-PD-L1 antibody, atezolizumab, until progression or unacceptable toxicity in previously treated advanced NSCLC, regardless of PD-L1 expression, patients, 28% of those in the experimental arm demonstrated long-term survival, defined as greater or equal to 24 months (10). In the Checkmate 153 trial, continuous nivolumab treatment resulted in grade 3 or higher immune-related adverse events in 8% of patients, compared to 4% in the 1-year fixed duration cohort, but very few new safety events took place after the first year of therapy (8) . CheckMate 153: randomized results of continuous vs 1-year fixed-duration nivolumab in patients with advanced non-small-cell lung cancer Early immune-related adverse events and association with outcome in advanced non-small cell lung cancer patients treated with nivolumab: a prospective cohort study cache = ./cache/cord-290200-csmisulw.txt txt = ./txt/cord-290200-csmisulw.txt === reduce.pl bib === id = cord-290551-a02tueuu author = Singh, Shailendra title = Impact of Obesity on Outcomes of Patients with COVID-19 in United States: A Multicenter Electronic Health Records Network Study. date = 2020-08-21 pages = extension = .txt mime = text/plain words = 2708 sentences = 157 flesch = 54 summary = title: Impact of Obesity on Outcomes of Patients with COVID-19 in United States: A Multicenter Electronic Health Records Network Study. We performed a retrospective cohort study using TriNetX (Cambridge, MA, USA), a global federated health research network that provided access to electronic medical records of patients from multiple large member healthcare organizations (HCOs) in United States. Our study using a large nationally representative database showed that COVID-19 patients with any degree of obesity had a significantly higher risk of hospitalization and intubation or death compared to patients without obesity. An analysis of a larger group of selected patients using diagnostic criteria of obesity as any time before the index event (after PSM n=9769) showed a higher risk for composite outcomes in the obesity group ( J o u r n a l P r e -p r o o f cache = ./cache/cord-290551-a02tueuu.txt txt = ./txt/cord-290551-a02tueuu.txt === reduce.pl bib === id = cord-290401-t87i3exo author = Bassetti, Matteo title = Principles of antimicrobial stewardship for bacterial and fungal infections in ICU date = 2017-09-12 pages = extension = .txt mime = text/plain words = 1638 sentences = 77 flesch = 36 summary = Source control performed after 12 h was not associated with higher mortality, implying that in high-risk patients even beyond the 12-h timeframe from admission, it may contribute to improved outcomes [5] . In another Spanish retrospective cohort of intraabdominal candidiasis (IAC), source control along with early antifungal treatment was associated with improved survival in both ICU and surgical wards, standing out as the main goal for decreasing mortality of IAC episodes inside and outside the ICU [13] . Numerous studies have demonstrated that the delay of initiation of antifungal therapy was associated with significant increases in both in-hospital mortality and the cost of care for patients with IC [16] . Association between source control and mortality in 258 patients with intra-abdominal candidiasis: a retrospective multi-centric analysis comparing intensive care versus surgical wards in Spain cache = ./cache/cord-290401-t87i3exo.txt txt = ./txt/cord-290401-t87i3exo.txt === reduce.pl bib === id = cord-290065-ouua7wnq author = Kashi, Mahine title = Severe arterial thrombosis associated with Covid-19 infection date = 2020-05-16 pages = extension = .txt mime = text/plain words = 705 sentences = 52 flesch = 40 summary = title: Severe arterial thrombosis associated with Covid-19 infection • We observed very severe arterial thrombotic complications in COVID-19 patients with cardiovascular history despite the use of antiplatelet or anticoagulant therapy, including five irreversible lower limb ischemia and two thoracic aortic free floating thrombi. • Further studies are needed to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients with peripheral arterial occlusive disease or thrombophilia. reporting the incidence of thrombotic complications in critically ill ICU patients diagnosed with Covid-19 1 . We report seven cases of severe arterial thrombotic events in patients infected with Covid-19. On We describe very severe arterial thrombotic complications occurring in COVID-19 patients despite the use of antiplatelet or anticoagulant therapy, including irreversible lower limb ischemia and free floating thrombi in the thoracic aorta. Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy cache = ./cache/cord-290065-ouua7wnq.txt txt = ./txt/cord-290065-ouua7wnq.txt === reduce.pl bib === id = cord-290295-gl144dh9 author = Martínez-López, Joaquín title = Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality date = 2020-10-19 pages = extension = .txt mime = text/plain words = 4086 sentences = 186 flesch = 36 summary = Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. There are cumulative data indicating that patients with cancer may be at increased risk for more severe COVID-19 and associated complications, including those receiving or not receiving treatment within the month prior to infection 5, 6 , although other recent results suggest mortality may be primarily associated with age, male sex, and comorbidities 7 . To our knowledge, this is the first large case-series study to describe comprehensively the clinical characteristics of COVID-19 in hospitalized MM patients, compare outcomes with a noncancer cohort of COVID-19 patients, and identify preadmission prognostic factors of inpatient mortality. cache = ./cache/cord-290295-gl144dh9.txt txt = ./txt/cord-290295-gl144dh9.txt === reduce.pl bib === id = cord-290267-ke696q8j author = Fang, Huilin title = Impact of comorbidities on clinical prognosis in 1280 patients with different types of COVID-19 date = 2020-10-13 pages = extension = .txt mime = text/plain words = 4880 sentences = 284 flesch = 52 summary = In this study, we included patients with COVID-19, divided them into ordinary, severe, and critical types according to the clinical manifestations at admission, and aimed to assess the impact of comorbidities on prognosis in patients with three different types of COVID-19, and to provide reference for the treatment of these patients. According to the Diagnosis and Treatment Program of Novel Coronavirus Pneumonia (Trial Seventh Edition) issued by the National Health Commission, all patients were divided into ordinary, severe, and critical types based on their clinical manifestations at admission. These results indicated that comorbidities can significantly affect the clinical course (length of hospital stay, time from onset to discharge) of ordinary patients, reduce the cure rate, and increase mortality rate of critical patients. In terms of clinical symptoms, ordinary patients without hypertension, diabetes, and coronary heart disease had a significantly higher proportion of fever compared with patients who had those comorbidities (p<0.05). cache = ./cache/cord-290267-ke696q8j.txt txt = ./txt/cord-290267-ke696q8j.txt === reduce.pl bib === id = cord-290658-r2bqqovo author = Qian, Hao title = Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: a Retrospective in-ICU Study date = 2020-10-16 pages = extension = .txt mime = text/plain words = 3550 sentences = 197 flesch = 44 summary = OBJECTIVE: The aim of this study was to investigate the incidence, clinical presentation, cardiovascular (CV) complications and mortality risk of myocardial injury on admission in critically ill ICU inpatients with COVID-19. We conducted a retrospective study of data from 77 patients admitted to a newly constructed ICU in Wuhan, compared patients with and without myocardial injury, detailed the relationship of myocardial injury with the survival rate and CV outcomes, and presented the following conclusions: 1) Myocardial injury is a common complication in critically ill COVID-19 patients; 2) Additionally, we further compared the mortality and time from ICU admission to death between the myocardial injury and non-myocardial injury patients, which suggested the predictive value of co-existing myocardial injury on admission as a high-risk factor in critically ill patients with COVID-19 in this study. cache = ./cache/cord-290658-r2bqqovo.txt txt = ./txt/cord-290658-r2bqqovo.txt === reduce.pl bib === id = cord-290341-ei768v4s author = Anstey, D. Edmund title = The cardiac intensive care unit and the cardiac Intensivist during the COVID-19 surge in New York City() date = 2020-07-03 pages = extension = .txt mime = text/plain words = 4209 sentences = 228 flesch = 44 summary = Herein we discuss the evolving role of the cardiac intensivist and changes to the CICU in the era of the COVID-19 pandemic and provide recommendations based on our own experiences at NewYork-Presbyterian Columbia University Irving Medical Center. There are several domains across which innovation may occur including the physical layout of the CICU, the timing of laboratory and diagnostic studies, medication administration, clinical monitoring, and the management of cardiac arrests. Timing of Lab Testing and Diagnostic Studies: As typical of critically ill patients, patients in an intensive care setting with COVID-19 will require frequent testing as part of their clinical assessment and management. The cardiac intensivist and staff also serve as a consultative resource throughout the hospital to other clinicians given the clinical expertise of the CICU in the management of critically ill patients with cardiovascular complications of COVID-19. cache = ./cache/cord-290341-ei768v4s.txt txt = ./txt/cord-290341-ei768v4s.txt === reduce.pl bib === id = cord-290712-flj352ql author = Bi, Jianping title = Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? date = 2020-09-04 pages = extension = .txt mime = text/plain words = 1345 sentences = 90 flesch = 49 summary = title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? Those studies mainly addressed whether chemotherapy could predict for hospitalization, severe disease, and mortality in cancer patients with COVID-19 infection. To address this knowledge gap, this study's findings suggest that administering chemotherapy to this population is associated with a very low short-term risk of SARS-CoV-2 reactivation. Third, the duration of follow-up in this study was relatively short and it may take a longer period of time to determine immune-related alterations caused by chemotherapy in cancer patients who have recovered from COVID-19 infection. Nevertheless, when conservatively interpreted, our study indicates no overt short-term increase in the risk for SARS-CoV-2 reactivation following immunosuppressive chemotherapy in this uniquely vulnerable population. To our knowledge, this is the first study reporting that recovered COVID-19 cancer patients remain negative in the short-term for SARS-CoV-2 after delivery of chemotherapy. cache = ./cache/cord-290712-flj352ql.txt txt = ./txt/cord-290712-flj352ql.txt === reduce.pl bib === id = cord-290051-22gwwrpw author = Masaki, Shigenori title = Endotracheal intubation in patients with COVID-19 using an ultrathin flexible gastrointestinal endoscope date = 2020-10-16 pages = extension = .txt mime = text/plain words = 1275 sentences = 77 flesch = 40 summary = Therefore, we simulated fiberoptic endotracheal intubation on a mannequin representing the patient, using an ultrathin flexible gastrointestinal endoscope as an alternative to the bronchoscope, in order to maintain distance from the patient during the procedure. Therefore, we simulated fiberoptic endotracheal intubation on a mannequin representing the patient, using an ultrathin flexible gastrointestinal endoscope as an alternative to the bronchoscope, in order to maintain distance from the patient during the procedure. The flexible tip-steerable control and length of the gastrointestinal endoscope contributed to shortening the procedure time and maintaining distance from the patients. The flexible tip-steerable control and length of the gastrointestinal endoscope contributed to shortening the procedure time and maintaining distance from the patients. Endotracheal intubation using an ultrathin flexible gastrointestinal endoscope is a quick and reliable procedure that can be performed while maintaining distance from the patient. cache = ./cache/cord-290051-22gwwrpw.txt txt = ./txt/cord-290051-22gwwrpw.txt === reduce.pl bib === id = cord-289852-4uxb70rh author = Kassem, Dina H. title = Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis date = 2020-09-30 pages = extension = .txt mime = text/plain words = 6959 sentences = 342 flesch = 44 summary = Thus, harnessing the immunomodulatory properties of mesenchymal stem cells (MSCs) to ameliorate that cytokine-storm can indeed provide a golden key for the treatment of COVID-19 patients, especially severe cases. In fact, MSCs transplantation can improve the overall outcome of COVID-19 patients via multiple mechanisms; first through their immunomodulatory effects which will help to regulate the infected patient inflammatory response, second via promoting tissue-repair and regeneration, and third through their antifibrotic effects. Similar studies are also warranted to compare the therapeutic benefit of a certain MSCs type, and its derived EVs. Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies Expanded umbilical cord mesenchymal stem cells (UC-MSCs) as a therapeutic strategy in managing critically ILL COVID-19 patients: the case for compassionate use Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial cache = ./cache/cord-289852-4uxb70rh.txt txt = ./txt/cord-289852-4uxb70rh.txt === reduce.pl bib === id = cord-290195-8uaai9nv author = Stebbing, Justin title = Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients date = 2020-05-30 pages = extension = .txt mime = text/plain words = 6584 sentences = 326 flesch = 46 summary = Furthermore, baricitinib treatment resulted in a significant reduction (p<0.05) from baseline in plasma IL-6 at week 12 in patients with active RA who had an inadequate response to methotrexate from a phase 2b (Tanaka, Emoto et al., 2016) , randomized, placebo-controlled, dose-ranging study (Fig. 1B) . As shown in Figure 3A , all four patients showed improvement with baricitinib treatment in signs and symptoms such as cough, fever, and reduction in plasma IL-6 levels, along with a reduction in the SARS-CoV-2 RNA viral load, as detected by the real-time reverse-transcriptase-polymerase chain reaction (RT-PCR) signal from the nasopharyngeal carriage. Therefore, the impact of baricitinib on the subsequent development of protective humoral and cell-mediated anti-viral immunity in COVID-19 patients must be evaluated in randomized clinical trials (Ottoviani & Stebbing, 2020) . The finding that baricitinib is a potent AAK1/BIKE/GAK inhibitor that may reduce host cell infectivity, along with reaffirmation of its anti-cytokine profile, provide reasons to study this intervention in randomized clinical trials. cache = ./cache/cord-290195-8uaai9nv.txt txt = ./txt/cord-290195-8uaai9nv.txt === reduce.pl bib === id = cord-290750-85731og8 author = Danese, Silvio title = Management of IBD during the COVID-19 outbreak: resetting clinical priorities date = 2020-03-25 pages = extension = .txt mime = text/plain words = 1798 sentences = 86 flesch = 49 summary = Because of the very high transmission capacity, the WHO declared the outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection a public health emergency of international concern. Additional recommendations for patients with IBD from the IOIBD: • Medicines such as mesalamine are safe • If possible, withdraw from steroid use • Biologic agents used to treat IBD (e.g. anti-TNF agents, ustekinumab and vedolizumab) are generally safe; there are no recommendations to stop taking these medications and the effects of these drugs are present for many months • Thiopurines and tofacitinib tend to inhibit the immune response to viral infections, but stopping these agents in the short-term will not help • Get the influenza vaccination • Stay at home and minimize social contact c | Strategies to enable maintenance of our biologic agent clinic during the COVID-19 outbreak in Italy include checkpoints at hospital entrances for symptom screening and use of surgical masks for clinical staff and patients. cache = ./cache/cord-290750-85731og8.txt txt = ./txt/cord-290750-85731og8.txt === reduce.pl bib === id = cord-290975-2kmvyovm author = Martinotti, Giovanni title = Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy date = 2020-09-03 pages = extension = .txt mime = text/plain words = 4250 sentences = 195 flesch = 41 summary = In this paper, we aim at evaluating the impact that the COVID-19 pandemic, and the relative containment measures, have had on a real-life sample of patients suffering from substance use disorders (SUDs) and/or behavioral addictions. Within the general population, problems such as feelings of frustration, aggressive behavior (2) , post-traumatic stress symptoms (PTSS), depression, anxiety, insomnia, perceived stress, and adjustment disorder symptoms (ADS) have increased (3) , with the consequent risk of self-medication through the abuse of alcohol and/or psychoactive substances and with a greater tendency to engage in pathological behaviors (gambling and internet addiction). The aim of this study was to evaluate the impact that the COVID-19 pandemic, and the relative containment measures adopted by the Italian Government, had on patients with SUDs and/or behavioral addictions; to assess the psychopathological burden in terms of depression, anxiety, post-traumatic load; and to evaluate the relevance of craving symptoms and their correlation with psychiatric symptoms and quality of life. cache = ./cache/cord-290975-2kmvyovm.txt txt = ./txt/cord-290975-2kmvyovm.txt === reduce.pl bib === id = cord-290326-umv0q4d7 author = Stachowska, Ewa title = Nutritional Support in Coronavirus 2019 Disease date = 2020-06-12 pages = extension = .txt mime = text/plain words = 5115 sentences = 241 flesch = 40 summary = Consequently, due to lack of specific COVID-19 data, the recommendations in our review are based on viral and bacterial pneumonia studies, as well as recommendations made for critically ill patients. Nutritional treatment for critically ill patients diagnosed with COVID-19 (especially in case of respiratory and multiorgan failure) [22] is a key element of comprehensive treatment aimed to reduce the mortality. American Society for Parenteral and Enteral Nutrition (ASPEN) criteria for increased risk for aspiration are: inability to protect the airway, mechanical ventilation, age > 70 years, reduced level of consciousness, poor oral care, inadequate nurse: patient ratio, supine positioning, neurologic deficits, gastroesophageal reflux, transport out of the ICU, and use of bolus intermittent EN. Poor nutritional status is a prognostic factor for mortality in severe pneumonia and critical illness, especially for elderly patients. ESPEN and ASPEN guidelines for nutritional support in critical illness are applicable for COVID-19 patients requiring ICU support. cache = ./cache/cord-290326-umv0q4d7.txt txt = ./txt/cord-290326-umv0q4d7.txt === reduce.pl bib === id = cord-291016-c83fs5ih author = Gori, Tommaso title = Perspective: cardiovascular disease and the Covid-19 pandemic date = 2020-04-10 pages = extension = .txt mime = text/plain words = 1623 sentences = 71 flesch = 42 summary = Furthermore, the new, emergency-driven changes to hospital logistics conflict with important principles of treatment of patients with acute coronary syndromes: patients with an undefined contact history or ambiguous symptoms are often approached as potential Sars-Cov-2 positive at the time of their medical contact. It is now of paramount importance that communication media inform the population that most large centers have restructured their admission protocols to provide a rapid and Covid-secure care of patients with acute coronary syndromes while still addressing the diagnosis of Sars-CoV-2 infection. International experts and the European Society of Cardiology "strongly recommend that physicians and patients should continue treatment with their usual anti-hypertensive therapy", given the lack of clinical or scientific evidence to suggest that treatment with angiotensin-converting enzyme inhibitors or angiotensinreceptor blockers might favor the spread or the severity of Sars-CoV-2 infection [9] . cache = ./cache/cord-291016-c83fs5ih.txt txt = ./txt/cord-291016-c83fs5ih.txt === reduce.pl bib === id = cord-291265-qmylxndp author = Moravvej, Zahra title = COVID-19 pandemic: Ophthalmic practice and precautions in a tertiary eye hospital in Iran date = 2020-04-23 pages = extension = .txt mime = text/plain words = 1219 sentences = 84 flesch = 50 summary = title: COVID-19 pandemic: Ophthalmic practice and precautions in a tertiary eye hospital in Iran 7 Here, we address the prevention strategies employed against COVID-19 according to assessments of infection control experts and ophthalmologists, in Amiralmomenin Hospital a tertiary referral eye hospital in Guilan, Iran. To avoid redundant visits to the hospital, patients who were managed in an outpatient setting were contacted via phone by eye-care professionals at appropriate intervals. Environmental surfaces frequently touched by staff and patients, such as light switches, door knobs, and nursing stations were cleaned according to Centers for Disease Control and Prevention (CDC) recommendations. The personal protective equipment for the eye-care nursing staff, ophthalmology residents, and attending eye surgeons included Latex gloves, eye protection (goggles or face shields), a surgical-style face mask, a long-sleeved fluid-resistant gown, and disposable shoe covers. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection Interim infection prevention and control recommendations for patients with suspected or confirmed coronavirus disease 2019 (COVID-19) in healthcare settings cache = ./cache/cord-291265-qmylxndp.txt txt = ./txt/cord-291265-qmylxndp.txt === reduce.pl bib === id = cord-290611-fhaguv3f author = Ghio, Stefano title = Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hospital in Northern Italy date = 2020-09-22 pages = extension = .txt mime = text/plain words = 3755 sentences = 158 flesch = 44 summary = Since the onset of coronavirus disease 2019 (COVID19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence has shown that patients with confirmed COVID-19 may present elevated blood levels of high-sensitivity TnI (hs-TnI) during hospital stay, which might reflect ischemic cardiovascular complications or acute myocarditis [1] [2] [3] . The main finding is that, in this cohort, in-hospital mortality was associated with older age, respiratory failure and elevated plasma levels of hs-TnI whereas cardiovascular comorbidities were not an independent risk factor at multivariable analysis. However, when age and respiratory failure at hospital admission were analyzed together with cardiac involvement in a multivariable analysis, only older age, a P/F ratio < 200 and elevated hs-TnI plasma levels were significant predictor of death and of the combined outcome. cache = ./cache/cord-290611-fhaguv3f.txt txt = ./txt/cord-290611-fhaguv3f.txt === reduce.pl bib === id = cord-291052-nstfe15a author = Cag, Yasemin title = A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort date = 2020-08-27 pages = extension = .txt mime = text/plain words = 1930 sentences = 125 flesch = 54 summary = This manuscript aims to present a treatment algorithm we applied to manage COVID-19 patients admitted to our hospital. We administered hydroxychloroquine plus doxycycline to mild cases (isolated at home) for 3 days and lopinavir plus doxycycline to moderate and severe cases (hospitalized) for 5 days. Second, moderate to severe cases were hospitalized and prescribed with a regimen of lopinavir plus doxycycline plus ceftriaxone for 5 days. We hospitalized moderate to severe cases and administered lopinavir combined with doxycycline and ceftriaxone to 343 patients, among whom 161 had positive PCR test results (161/343, 46.9%). We administered hydroxychloroquine to mild cases isolated at home, lopinavir plus doxycycline to hospitalized moderate to severe cases, and favipiravir in the salvage treatment. We concluded that home isolation of mild cases is an effective means to manage the burden of disease, while lopinavir plus doxycycline is an alternative to current treatment regimens for COVID-19. cache = ./cache/cord-291052-nstfe15a.txt txt = ./txt/cord-291052-nstfe15a.txt === reduce.pl bib === id = cord-290832-zmj59rc3 author = Recinella, Guerino title = Prognostic role of nutritional status in elderly patients hospitalized for COVID-19: a monocentric study date = 2020-10-08 pages = extension = .txt mime = text/plain words = 2985 sentences = 169 flesch = 44 summary = AIMS: To assess the role of nutritional status as an independent prognostic factor for in-hospital death in elderly patients. At univariate analysis, age (HR 1.045 [CI 1.008–1.082]), cognitive impairment (HR 1.949 [CI 1.045–3.364]), C-reactive protein (HR 1.004 [CI 1.011–1.078]), lactate dehydrogenases (HR 1.003 [CI 1.001–1.004]) and GNRI moderate–severe risk category (HR 8.571 [CI 1.096–67.031]) were risk factors for in-hospital death, while albumin (HR 0.809 [CI 0.822–0.964]), PaO(2)/FiO(2) ratio (HR 0.996 [CI 0.993–0.999]) and body mass index (HR 0.875 [CI 0.782–0.979]) were protective factors. The main result of our study is that impaired nutritional status, assessed by the GNRI, together with the PaO 2 /FiO 2 ratio, is an independent predictor of in-hospital mortality in elderly patients with symptomatic SARS-CoV-2 infection. Future larger and multicentric studies are needed to validate our results on the prognostic value of GNRI in predicting in-hospital death and to further explore the role of other nutritional parameters in elderly patients hospitalized for COVID-19. cache = ./cache/cord-290832-zmj59rc3.txt txt = ./txt/cord-290832-zmj59rc3.txt === reduce.pl bib === id = cord-290856-6de0mwg0 author = Abbo, Aharon (Ronnie) title = Technological Developments and Strategic Management for Overcoming the COVID-19 Challenge within the Hospital Setting in Israel date = 2020-07-31 pages = extension = .txt mime = text/plain words = 4152 sentences = 188 flesch = 40 summary = A second key component of this challenge was the overwhelming surge in patient burden and the relative lack of trained staff and medical equipment which required rapid re-organization of large systems and augmenting health care efficiencies to unprecedented levels. This review article describes the early research and development response in Israel under the scope of in-hospital patient care, such as non-contact sensing of patients' vital signs, and how it could potentially be weaved into a practical big picture at the hospital or national level using a strategic management system. This review article describes the early research and development response in Israel under the scope of in-hospital patient care, and how it could potentially be weaved into a practical strategic big picture that could help confront the next wave or any upcoming health crisis. The C 4 I™ system is a command and control tactical system integrating computing, communication, and intelligence information (for health care applications this applies for patient sensors), developed for military use by Elbit Systems. cache = ./cache/cord-290856-6de0mwg0.txt txt = ./txt/cord-290856-6de0mwg0.txt === reduce.pl bib === id = cord-290947-5ewpvo4j author = Carda, Stefano title = The role of physical and rehabilitation medicine in the COVID-19 pandemic: the clinician's view date = 2020-04-18 pages = extension = .txt mime = text/plain words = 1545 sentences = 85 flesch = 43 summary = The Chinese Center for Disease Control recently published data on 44,672 patients infected with SARS-CoV-2 (1) , showing that 88% of patients were < 70 years old, with an overall mortality rate of 2%, but 19% of cases needed hospitalization in an intensive care unit (ICU). The proportion of patients with COVID-19-related disability will be rapidly growing, and a prompt response from physical medicine and rehabilitation (PMR) specialists is crucial to reduce disability and help re-establish and optimize the function of the acute hospital setting. The most common forms are 1) mild: no dyspnea, no low blood oxygen saturation (SatO2); 2) moderate: dyspnea, SatO2 94% to 98%, radiological signs of pneumonia; 3) severe: dyspnea, SatO2 ≤ 93%, respiratory rate (RR) >30/min, radiological progression of lesions, with O2 supplementation required, eventually with non-invasive ventilation; and 4) critical: patients need mechanical ventilation. cache = ./cache/cord-290947-5ewpvo4j.txt txt = ./txt/cord-290947-5ewpvo4j.txt === reduce.pl bib === id = cord-291024-9g4om4sf author = Isakbaeva, Elmira T. title = SARS-associated Coronavirus Transmission, United States date = 2004-02-17 pages = extension = .txt mime = text/plain words = 3669 sentences = 160 flesch = 53 summary = To better assess the risk for transmission of the severe acute respiratory syndrome–associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. To that end, we obtained serial biologic specimens and clinical and exposure data for 5 to 10 weeks after onset of illness from seven laboratory-confirmed U.S. SARS patients and their household contacts. We detected SARS-CoV in fecal and respiratory specimens and found that SARS case-patients may have high concentrations of virus in stools during the 2nd week of illness and continue to shed the virus in feces until at least 26 days after onset of symptoms. All upper respiratory specimens in the first 2 weeks after onset were negative for SARS-CoV by RT-PCR; this finding differs from a report in Hong Kong, where viral RNA was detected in nasopharyngeal aspirates of 68% of case-patients at day 14 (21) . cache = ./cache/cord-291024-9g4om4sf.txt txt = ./txt/cord-291024-9g4om4sf.txt === reduce.pl bib === id = cord-291340-8gj0ofmp author = Misra, Anoop title = Balanced Nutrition is Needed in Times of COVID19 Epidemic in India: A Call for Action for all Nutritionists and Physicians date = 2020-08-27 pages = extension = .txt mime = text/plain words = 2147 sentences = 123 flesch = 40 summary = In a Cochrane review [26] , and other studies [27] probiotics were shown to decrease upper respiratory infections through their effect on the gut lung axis [28] Role of several other nutrients and food constituents like Vitamins(E, B) Carotenoids, minerals (Fe, Zn, Mg, Cu, Se), and polyphenols in immunity have been suggested because of their effects on inflammatory cascade, antioxidant activities and effects on nitrous oxide signalling pathways [25] (Table 1) . Controlled trials also show reduced complications when serum albumin level is adequate [44] .In a recent scoping review(four studies in patients with ventilator-related pneumonia and acute respiratory distress syndrome, and the other 4 in patients with ventilator-associated pneumonia), intravenous ascorbic acid, intramuscular cholecalciferol, enteral and intramuscular vitamin E, enteral zinc sulphate, and oral and parenteral glutamine were given as interventions. cache = ./cache/cord-291340-8gj0ofmp.txt txt = ./txt/cord-291340-8gj0ofmp.txt === reduce.pl bib === id = cord-290836-jldfrec9 author = Laosa, Olga title = Rapid assessment at hospital admission of mortality risk from COVID-19: the role of functional status date = 2020-10-08 pages = extension = .txt mime = text/plain words = 1857 sentences = 120 flesch = 55 summary = Objective To evaluate the role of functional status along with other used clinical factors on the occurrence of death in patients hospitalized with COVID-19. Estimated model coefficients served to calculate the expected probability of death for a selected combination of five variables: Barthel, sex, age, comorbidities and severity index (qSOFA). Evidence is even smaller regarding the joint 47 Therefore, the aim of this study was to evaluate, in patients hospitalized with COVID50 19, the role of limitations in activities of daily living along with other habitual clinical 51 factors on death during hospitalization, building a predictive model. Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study cache = ./cache/cord-290836-jldfrec9.txt txt = ./txt/cord-290836-jldfrec9.txt === reduce.pl bib === id = cord-290771-18dj37dj author = Tzeng, Ching-Wei D. title = Cancer Surgery Scheduling During and After the COVID-19 First Wave: The MD Anderson Cancer Center Experience date = 2020-05-18 pages = extension = .txt mime = text/plain words = 4865 sentences = 225 flesch = 37 summary = CONCLUSIONS: Cancer surgeons should continue to use their oncologic knowledge to determine the window of opportunity for each surgical procedure, based on tumor biology, preoperative treatment sequencing, and response to systemic therapy, to safely guide patients through this cautious recovery phase. Total surgical case volume by week during early COVID-19 response, in which MD Anderson Cancer Center implemented goals to create a ''moat'' around hospitalized patients, to reduce workforce and visitor traffic, and to limit ''elective'' cases. Because the Department of Surgical Oncology and MD Anderson Cancer Center have traditionally favored neoadjuvant therapy for many solid tumors, we strategically initiated or continued this treatment sequencing when possible to postpone surgery to beyond the late April peak of COVID-19 incidence in the Houston area. cache = ./cache/cord-290771-18dj37dj.txt txt = ./txt/cord-290771-18dj37dj.txt === reduce.pl bib === id = cord-291168-4u4cssky author = Martin-Villares, Cristina title = Outcome of 1890 tracheostomies for critical COVID-19 patients: a national cohort study in Spain date = 2020-08-04 pages = extension = .txt mime = text/plain words = 3217 sentences = 215 flesch = 55 summary = METHODS: A multicentric prospective observational study of 1890 COVID-19 patients undergoing tracheostomy across 120 hospitals was conducted over 7 weeks in Spain (March 28 to May 15, 2020). The group has performed a national multicentric prospective observational study on 1890 COVID-19 critical patients undergoing tracheostomy in a total of 120 hospitals in Spain. On early March, 2020, at a very critical moment of the pandemic in Spain and without published data yet from initial experiences in China or Italy, Spanish otolaryngologists began their first tracheostomies in Madrid (March, 11) and Barcelona (March, 16) , with the onrush of more than a thousand patients in their respective overcrowded ICUs, which doubled its current capacity. Between March 28 and May 15, the Spanish COVID Group, encompassing 120 hospitals, performed 1890 tracheostomies, the equivalent of 16.4% of all registered ICU patients with mechanical ventilation in Spain. cache = ./cache/cord-291168-4u4cssky.txt txt = ./txt/cord-291168-4u4cssky.txt === reduce.pl bib === id = cord-291397-look6ddt author = Roberto, Palumbo title = Current treatment of COVID-19 in renal patients: hope or hype? date = 2020-09-28 pages = extension = .txt mime = text/plain words = 5827 sentences = 326 flesch = 46 summary = Given the lack of specific therapy about the ongoing SARS-CoV-2 infection, we conducted a brief review to summarize the mechanism of action and the potentially side effects of the treatment currently available, focusing on the effects of the drugs on renal disease at different stages in terms of therapeutic management and survival. A randomized clinical trial, handled by a Chinese group, suggested that in hospitalized adult patients with severe infection, no benefit was observed with lopinavir/ritonavir beyond standard care in terms of time to clinical improvement, reduction of mortality and safety (side effects and discontinuation of treatment) [29, 30] . Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial cache = ./cache/cord-291397-look6ddt.txt txt = ./txt/cord-291397-look6ddt.txt === reduce.pl bib === id = cord-291176-evb6yt0r author = Giorgi Rossi, Paolo title = Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy date = 2020-08-27 pages = extension = .txt mime = text/plain words = 4559 sentences = 213 flesch = 46 summary = In this report, based on the cohort of all residents in the province of Reggio Emilia who were SARS-CoV-2-positive at nasal and pharyngeal swab and with symptoms (COVID-19 cases) since the inception of the epidemic, we describe patient characteristics and explore their role as putative prognostic factors in predicting the occurrence of hospital admission or death. We considered the following patient characteristics: age, sex, place of birth (Italy or abroad), time span (in days) from symptom onset to diagnosis/ hospitalization, and comorbidities, whose prognostic role was explored both singly (chronic obstructive pulmonary disease, arrhythmia, diabetes, coronary heart disease, heart failure, vascular diseases, obesity) and by computing the Charlson Comorbidity Index, which provides an overall measure of an individual patient's complexity [12] . While in this study we focused on the risk of hospitalization and death in a cohort of COVID-19 patients diagnosed during the epidemic in Northern Italy, it also provided us with the opportunity to describe the pattern of distribution of the disease in the whole population. cache = ./cache/cord-291176-evb6yt0r.txt txt = ./txt/cord-291176-evb6yt0r.txt === reduce.pl bib === id = cord-291025-u5z8zji3 author = Karami, Parisa title = Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings date = 2020-04-11 pages = extension = .txt mime = text/plain words = 2872 sentences = 157 flesch = 50 summary = title: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings According to the data, several clinical outcomes such as sepsis, respiratory failure, acute respiratory distress syndrome (ARDS), septic shock, coagulopathy, acute cardiac injury, and acute kidney injury are significantly (all P-values < 0.0001) higher in non-survivor patients compared to survivors. To our knowledge, this case is the first maternal death reported for pregnant patients diagnosed with COVID-19 so far. An early study has evaluated the outcome of nine pregnant patients with COVID-19 without any specific underlying diagnosed diseases (all gestational ages ≥36 weeks). Another study evaluated 13 pregnant patients (two cases < and 11 cases≥ 28 week of gestation) diagnosed with COVID-19. This case with the mentioned clinical, imaging, and laboratory data was the first report of COVID-19 pregnancy mortality. cache = ./cache/cord-291025-u5z8zji3.txt txt = ./txt/cord-291025-u5z8zji3.txt === reduce.pl bib === id = cord-291244-o4isx15k author = Ikuyama, Yuichi title = Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date = 2020-05-31 pages = extension = .txt mime = text/plain words = 2382 sentences = 133 flesch = 44 summary = Herein, we report a case of critical COVID-19 pneumonia treated with extracorporeal membrane oxygenation from symptom onset day 19 (SOD#19) to SOD#30. Here, we report the clinical course of a patient with a severe case of COVID-19 complicated with acute respiratory distress syndrome (ARDS). We report the patient's response to intensive care, including invasive ventilation in the early stage of the illness and extracorporeal membrane oxygenation (ECMO) with antiviral, immunomodulatory, and glucocorticoid therapies as the illness progressed. In this case, ECMO showed great effectiveness 13 in treating the patient's rapidly deteriorating respiratory status due to pneumonia. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study • A critical case of 76-year-old female with COVID-19 pneumonia.• No significant clinical benefits of lopinavir-ritonavir and peramivir treatment.• The pneumonia rapidly progressed to acute respiratory distress syndrome.• Extracorporeal membrane oxygenation from illness day 21 to 31 lead to recovery. cache = ./cache/cord-291244-o4isx15k.txt txt = ./txt/cord-291244-o4isx15k.txt === reduce.pl bib === id = cord-291388-tt9eq7e0 author = Wang, Jann-Tay title = Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients date = 2004-05-17 pages = extension = .txt mime = text/plain words = 4355 sentences = 226 flesch = 50 summary = Previous reports have described some major clinical findings of SARS, including the temporal progression of clinical symptoms and chest radiography, the outcomes, suggested treatment protocol, and risk factors for death (4, 5) . We report on the clinical features of our SARS patients with pneumonia, with emphasis on temporal progression of laboratory findings, treatment outcome, and risk factors for poor prognosis. Methylprednisolone was usually administered in the second week of the disease if any of the following occurred: a flare of fever, progression of clinical symptoms (such as dyspnea or diarrhea), a surge or resurge of CRP level, or rapid deterioration of chest radiographic findings (development of new infiltration). A previous study reported the temporal progression of clinical and radiologic findings in SARS patients and indicated that several parameters would become more severe in the second and third week of disease (5). cache = ./cache/cord-291388-tt9eq7e0.txt txt = ./txt/cord-291388-tt9eq7e0.txt === reduce.pl bib === id = cord-291469-cohrewj5 author = Cortese, Bernardo title = How is the cardiovascular patient managed during Covid‐19 pandemic? A report from the frontline date = 2020-05-20 pages = extension = .txt mime = text/plain words = 490 sentences = 30 flesch = 61 summary = His father had died of sudden death after 3 days of remittent chest pain and dyspnea, but did not come to our emergency room for the Luckily, we expect that the vast majority of patients with cardiovascular disease in the Covid-era will survive, and will ultimately develop heart failure in the next few months. Since the beginning of the pandemic, we have heard of protocols, distance, masks, lock-down, but not a single word has been spent regarding how will we be able to manage the new cardiovascular pandemic in the next few months, when everything will be open again and patients will not refuse to come to our emergency rooms and office visits. However, since the median stay of a Covid-19 patient in Lombardy is 23 days if he had a transit through the ICU, and 14 days if not, 3-5 it is expected that in the next 2-3 months all hospitals in the region will have dedicated resources and wards for this disease. cache = ./cache/cord-291469-cohrewj5.txt txt = ./txt/cord-291469-cohrewj5.txt === reduce.pl bib === id = cord-291413-cgec7150 author = Al-Jehani, Hosam title = MENA-SINO Consensus Statement on Implementing Care Pathways for Acute Neurovascular Emergencies During the COVID-19 Pandemic date = 2020-08-25 pages = extension = .txt mime = text/plain words = 3757 sentences = 240 flesch = 48 summary = There are several challenges facing endovascular therapy for stroke, including shortages of medical staff who may be deployed for COVID-19 coverage or who may have contracted the infection and are thus quarantined, patients avoiding early medical care, a lack of personal protective equipment, delays in door-to-puncture time, anesthesia challenges, and a lack of high-intensity intensive care unit and stroke ward beds. As a leading regional neurovascular organization, the Middle East North Africa Stroke and Interventional Neurotherapies Organization (MENA-SINO) has established a task force composed of medical staff and physicians from different disciplines to establish guiding recommendations for the implementation of acute care pathways for various neurovascular emergencies during the current COVID-19 pandemic. As a leading regional neurovascular organization, the Middle East North Africa Stroke and Interventional Neurotherapies Organization (MENA-SINO) has established a task force composed of medical staff and physicians from different disciplines to establish guiding recommendations for the implementation of acute care pathways for various neurovascular emergencies during the current COVID-19 pandemic. cache = ./cache/cord-291413-cgec7150.txt txt = ./txt/cord-291413-cgec7150.txt === reduce.pl bib === id = cord-291624-fod0eyuj author = Malone, Robert W. title = COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms date = 2020-06-22 pages = extension = .txt mime = text/plain words = 6496 sentences = 354 flesch = 43 summary = We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H (2) activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release. Patients with COVID-19 disease can present with a range of mild to severe non-speci c clinical signs and symptoms which develop two to fourteen days after exposure to SARS-CoV-2. The most likely mechanisms of actions include: via antiviral activity, via novel human targets, or via the on-target mechanism described in the current FDA market authorization-famotidine is a histamine receptor H 2 antagonist (and inverse agonist). To assess the possibility that famotidine may inhibit SARS-CoV-2 infection by other routes, a Vero E6 cell-based assay was performed to compare median tissue culture infectious doses (TCID50/mL) of famotidine, remdesivir, and hydroxychloroquine ( Figure 2 ). In both of these studies, the observed non-in ammatory edema in early-stage COVID-19 pulmonary disease is consistent with histamine release by mast cells. cache = ./cache/cord-291624-fod0eyuj.txt txt = ./txt/cord-291624-fod0eyuj.txt === reduce.pl bib === id = cord-291588-tp89j1kk author = Dorche, Maryam Sharifian title = Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic date = 2020-08-07 pages = extension = .txt mime = text/plain words = 5579 sentences = 431 flesch = 42 summary = During the current pandemic, 370 patients with SARS-CoV-2 infection out of 37 studies (Table 3) were reported to suffer from AIS or transient ischemic attack (TIA). (145) Acute Necrotizing Encephalopathy(ANE) which was reported in 8 patients (Table 3) with COVID-19 is a distinct entity defined as rapid onset of neurological symptoms often secondary to a viral infection such as herpes viruses and influenza. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series Evolution and resolution of brain involvement associated with SARS-CoV2 infection: A close Clinical -Paraclinical follow up study of a case EEG Findings in Acutely Ill Patients Investigated for SARS-CoV-2/COVID-19: A Small Case Series Preliminary Report. Guillain-Barré syndrome in a patient infected with SARS-CoV-2, a case report Guillain-Barré Syndrome as a Neurological Complication of Novel COVID-19 Infection: A Case Report and Review of the Literature cache = ./cache/cord-291588-tp89j1kk.txt txt = ./txt/cord-291588-tp89j1kk.txt === reduce.pl bib === id = cord-291686-kgewmqg5 author = Patel, Surendra title = Prioritizing cardiovascular surgical care in COVID‐19 pandemic: Shall we operate or defer? date = 2020-07-15 pages = extension = .txt mime = text/plain words = 1620 sentences = 98 flesch = 46 summary = Moreover there is lack of sufficient data regarding impact of COVID-19 on post operative outcomes in patients who were infected with novel coronavirus and underwent cardiac and thoracic procedures. Peng et al 3 reported that patient who underwent thoracic surgery at the time of pandemic and later found to be affected with the novel coronavirus had greater than anticipated incidence of severe illness as well as case fatality rate, thus emphasizing the importance of correct triage and prioritizing cases to be considered for cardiac and thoracic surgery. 14 American college of surgeons has defined triage guidelines for vascular surgery patients, 8 and have provided guidelines regarding whether to postpone or not, vascular surgical procedures including, ascending aortic aneurysm, peripheral aneurysms, aortic dissection, mesenteric ischemia, peripheral vascular disease, trauma, venous thromboembolism, and amputation of limbs (Table 2) . cache = ./cache/cord-291686-kgewmqg5.txt txt = ./txt/cord-291686-kgewmqg5.txt === reduce.pl bib === id = cord-291417-p49ukyhx author = Mikulska, Malgorzata title = Tocilizumab and steroid treatment in patients with COVID-19 pneumonia date = 2020-08-20 pages = extension = .txt mime = text/plain words = 4441 sentences = 219 flesch = 44 summary = METHODS: This observational single-center study included patients with COVID-19 pneumonia who were not intubated and received either standard of care (SOC, controls) or SOC plus early (within 3 days from hospital admission) anti-inflammatory treatment. This observational single-center study included patients with COVID-19 pneumonia who were not intubated and received either standard of care (SOC, controls) or SOC plus early (within 3 days from hospital admission) anti-inflammatory treatment. We hypothesized that outcomes such as no need for intubation and survival of patients with severe COVID-19 pneumonia in whom tocilizumab and/or methylprednisolone were administered in addition to standard of care (SOC) could be better than in those who received only SOC. In this observational study in non-intubated patients with mainly severe COVID-19 pneumonia, the early addition of tocilizumab and/or methylprednisolone to SOC resulted in adjusted failure-free survival of 86.5% and 80.8% at day 14 and 30, which was, respectively, 10.7% and 16.7% higher than in SOC patients. cache = ./cache/cord-291417-p49ukyhx.txt txt = ./txt/cord-291417-p49ukyhx.txt === reduce.pl bib === id = cord-291430-rsu6xviv author = Zhang, Qian title = A Mysterious Paratracheal Mass: Parathyroid Carcinoma date = 2020-07-11 pages = extension = .txt mime = text/plain words = 1775 sentences = 117 flesch = 49 summary = He was subsequently found to have parathyroid carcinoma as the cause of the acute encephalopathy with impressive serum calcium and parathyroid hormone levels. According to a systemic review conducted from 1995-2003 by Ruda et al., parathyroid carcinoma accounted for 0.74% of cases out of the total study population of 22,225 patients [3] . On days 4-10 of hospitalization, the patient became more lucid as serum calcium level had normalized to 9.1 mg/dL with treatment. The patient remained to have normal serum calcium levels with elevated PTH levels for the next few days. The primary treatment for parathyroid carcinoma is surgical resection, as it offers the greatest chance for potential cure [11] . However, it is advised that the serum calcium levels should be controlled prior to surgery as our patient's hypercalcemia was normalized after being treated with intravenous fluids, calcitonin, cinacalcet, and pamidronate. Surgical treatment of parathyroid carcinoma (review) cache = ./cache/cord-291430-rsu6xviv.txt txt = ./txt/cord-291430-rsu6xviv.txt === reduce.pl bib === id = cord-291670-mqj071gp author = Raredon, M. S. B. title = Pressure-Regulated Ventilator Splitting (PReVentS): A COVID-19 Response Paradigm from Yale University date = 2020-04-06 pages = extension = .txt mime = text/plain words = 8502 sentences = 488 flesch = 56 summary = -Pressure-control ventilation mode is optimal and assumed for this design -Pressure readouts on the ventilator screen reflect unmodified pressures delivered by the ventilator, and are not representative of what each patient is seeing -PIP and PEEP for each patient are obtained by adding/subtracting each patient's valve settings from displayed ventilator settings -see below -Tidal volume readout on the ventilator is total tidal volume for both patients -Additional monitors may be deployed in-line for each patient, to measure tidal volumes and airway pressures individually and in real time -FIO2 and respiratory rate are the same for both patients -Tidal volumes will differ for each patient, depending on PIP, PEEP and lung compliance -A short circuit from the ventilator outflow to ventilator inflow is necessary to avoid triggering of circuit occlusion alarm and to allow ventilator bias flow -Because of changes to the expected circuit, ventilator alarms will not always work as expected, and an alternate alarm strategy must be employed (see discussion below) cache = ./cache/cord-291670-mqj071gp.txt txt = ./txt/cord-291670-mqj071gp.txt === reduce.pl bib === id = cord-292056-dtdyxhq4 author = Ghogawala, Zoher title = Editorial. COVID-19 and spinal surgery date = 2020-04-17 pages = extension = .txt mime = text/plain words = 1393 sentences = 74 flesch = 51 summary = Second, the neurosurgery workflow was changed dramatically by the cancellation of elective surgery cases in order to increase hospital capacity for future COVID-19 patients. In most hospitals, all interventional spine procedures have been postponed to decrease patient exposure to COVID-19 and allow surgeons to focus their efforts on the treatment of patients who require urgent care. As more patients are admitted to hospitals with active COVID-19 infections, the risk of exposure for spinal surgeons increases. While caring for COVID-19-positive patients who might need emergency spine surgery, all personnel are required to wear N95 masks and no personnel other than the anesthesiologist are allowed in the OR for 30 minutes following intubation. As elective surgery has been reduced in hospitals, many spinal surgeons have been asked to participate in the care of medical patients. Having models to compensate physicians and hospitals for the effective use of telehealth will be one positive aspect of this crisis, which has provided many opportunities for new learning. cache = ./cache/cord-292056-dtdyxhq4.txt txt = ./txt/cord-292056-dtdyxhq4.txt === reduce.pl bib === id = cord-292345-zc209dfx author = Carroll, Elizabeth title = Catastrophic Intracranial Hemorrhage in Two Critically Ill Patients with COVID-19 date = 2020-05-26 pages = extension = .txt mime = text/plain words = 1580 sentences = 90 flesch = 51 summary = Although it has been noted that COVID-19 may increase risk for acute cerebrovascular events, including both ischemic and hemorrhagic stroke [2] , to our knowledge, this is the first report of patients with COVID-19 who had catastrophic intracranial hemorrhages. To address this, Thachil noted that use of anticoagulation in patients with elevated D-dimers may decrease mortality by both preventing thrombi and dampening the inflammatory response triggered by COVID-19 [7] . Thus, at our center, it was decided that therapeutic anticoagulation should be initiated empirically for patients with COVID-19 who have a D-dimer > 10,000 ng/ mL and considered for patients who have a D-dimer between 2000 and < 10,000 ng/mL using treatment dose enoxaparin or heparin titrated to a low therapeutic anti-Xa goal of 0.3-0.5 U/mL. cache = ./cache/cord-292345-zc209dfx.txt txt = ./txt/cord-292345-zc209dfx.txt === reduce.pl bib === id = cord-291566-jwlvustd author = Wells Mulherin, Diana title = ASPEN Report on Nutrition Support Practice Processes With COVID‐19: The First Response date = 2020-07-16 pages = extension = .txt mime = text/plain words = 5727 sentences = 272 flesch = 49 summary = This paper summarizes clinician reports on these changed processes, including overall nutrition care, nutrition assessment, enteral nutrition and parenteral nutrition care steps, and food and oral supplement delivery. Experience and research on nutrition support therapy in patients with COVID-19 has brought about new healthcare practice processes that include telemedicine, personal protective equipment (PPE), and exposure limitations. Inpatient nutrition support clinicians working from home have found it challenging to be involved in patient care rounds. Nutrition clinicians are also using telephone or video conferencing to round with the primary medical teams to see patients together and limit going into patients' rooms to minimize COVID-19 exposure. Some dietitians are reporting that patients with COVID-19 infections are in negative-pressure rooms, and therefore they do not need to wear entire PPE on the patient care unit, which allows them greater access to other healthcare professionals. cache = ./cache/cord-291566-jwlvustd.txt txt = ./txt/cord-291566-jwlvustd.txt === reduce.pl bib === id = cord-291697-wpnq9wc0 author = Riechelmann, Rachel P title = Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group date = 2020-05-22 pages = extension = .txt mime = text/plain words = 5855 sentences = 390 flesch = 44 summary = RESULTS: Overall and tumour-specific recommendations were made by stage (including surgical, locoregional, radiotherapy, systemic treatments and follow-up strategies) for the most common gastrointestinal malignancies: esophagus, gastric, pancreas, bile duct, hepatocellular, colorectal, anal cancer and neuroendocrine tumours. All the recommendations proposed in this manuscript, besides being evidencebased, aimed at the following objectives: (1) to prioritise curative-intent cancer treatments during the pandemic; (2) to support the treatment of aggressive tumours when effective therapies are available; (3) to decrease the number of or delay oncological non-priority surgeries; (4) to decrease hospital visits (e.g., substitute intravenous for similarly effective oral drugs; propose when and to whom treatments delays/ interruption/watchful waiting can be offered); (5) to minimise anticancer therapy-related immunosuppression in specific high-risk groups (here defined as: elderly, comorbid illnesses [especially diabetes, cardiovascular and/or pulmonary concurrent diseases], fragility, ECOG 2 or higher). cache = ./cache/cord-291697-wpnq9wc0.txt txt = ./txt/cord-291697-wpnq9wc0.txt === reduce.pl bib === id = cord-292315-7vwybku8 author = Jung, Gyuwon title = Too Much Information: Assessing Privacy Risks of Contact Trace Data Disclosure on People With COVID-19 in South Korea date = 2020-06-18 pages = extension = .txt mime = text/plain words = 7867 sentences = 373 flesch = 51 summary = Then, an ordinal scale of relative privacy risk levels was introduced for evaluation, and the assessment was performed on the personal information included in the contact trace data, such as demographics, significant places, sensitive information, social relationships, and routine behaviors. As shown in Table 2 , the released contact trace data included (1) the patient's demographics (i.e., nationality, gender, age, and residence), (2) infection information (i.e., infection route and confirmation date), and (3) travel log in time series (e.g., transport modes and visited places). The codebook has an ordinal scale of privacy risk levels and the scale quantifies relative risks from five major categories: demographics (nationality, gender, age), significant places (residence, workplace), sensitive information (hobby, religion, accommodation), social relationships, and routine behavior. In particular, the data from Sejong revealed the most detailed information on significant places (the average privacy risk levels for residence and workplace in Sejong were over level 3), whereas Ulsan showed a relatively high percentage of data disclosure on social relationships (i.e., 72.4% of the confirmed patients in Ulsan). cache = ./cache/cord-292315-7vwybku8.txt txt = ./txt/cord-292315-7vwybku8.txt === reduce.pl bib === id = cord-292474-dmgd99d6 author = Berardi, Giammauro title = Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center date = 2020-06-04 pages = extension = .txt mime = text/plain words = 4605 sentences = 222 flesch = 43 summary = As the Italian National Institute for the Infectious Diseases, we have hospitalized the first Italian COVID-19 patients and since then, our general surgery department had to face this reality [16] . Pancreatic resections, total gastrectomies, major hepatectomies, and multivisceral resections as well as liver and kidney transplantations were considered as the high-risk surgical procedures because of the increased likelihood of postoperative ICU admission. On January 31, 2020 (Day 0), the first two COVID-19-positive patients in Italy were admitted to the department of infectious diseases of our hospital with mild fever and atypical pneumonia requiring no invasive treatment. Considering only the transplantations and the operations performed for cancer, patients in the second period had fewer comorbidities, lower ASA score, CCI, and RCRI, being overall at lower risk of postoperative ICU admission (Table 3) . As an institutional policy, our transplant center remained opened and we decided to continue with our standard surgical oncology activity, improving selection of patients to limit the need for postoperative intensive care management. cache = ./cache/cord-292474-dmgd99d6.txt txt = ./txt/cord-292474-dmgd99d6.txt === reduce.pl bib === id = cord-292054-x0saq938 author = Hashizume, Misato title = Outlook of IL-6 signaling blockade for COVID-19 pneumonia date = 2020-10-05 pages = extension = .txt mime = text/plain words = 3798 sentences = 182 flesch = 43 summary = Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population. Elevated tissue and serum levels of IL-6 have been implicated in the disease pathology of several inflammatory and autoimmune disorders including multiple myeloma, Crohn's disease, rheumatoid arthritis (RA), Castleman disease, systemic juvenile idiopathic arthritis (sJIA), polyarticular juvenile idiopathic arthritis (pJIA), adult-onset Still's disease (AOSD), ankylosing spondylitis, psoriatic arthritis, systemic lupus erythematosus, giant cell arteritis (GCA), Takayasu arteritis (TAK), systemic sclerosis, and cytokine-release syndrome (CRS), and targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic conditions such as RA, JIA, AOSD, GCA, TAK, and others such as Castleman disease or chimeric antigen receptor (CAR) T cell-induced CRS [2] . cache = ./cache/cord-292054-x0saq938.txt txt = ./txt/cord-292054-x0saq938.txt === reduce.pl bib === id = cord-291687-kwu0otpi author = Judson, Gregory L. title = Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection date = 2020-06-13 pages = extension = .txt mime = text/plain words = 5569 sentences = 273 flesch = 40 summary = A review of 44,672 confirmed COVID-19 cases from Wuhan, China, demonstrated increased mortality in patients with cardiovascular disease (10.5%), diabetes (7.3%), and hypertension (6%), which was significantly higher than the overall case-fatality rate of 2.3% [22] . These initial cases series have shown a similar relationship between underlying cardiac comorbidities with a higher prevalence of hypertension, diabetes, coronary artery disease, and obesity in patients requiring mechanical ventilation [24] . Early studies reported a prevalence of acute cardiac injury of 12% in the entire cohort as defined by either high sensitivity troponin (Hs Tn) or the MB fraction of creatinine kinase (CK-MB) [ 99 th percentile or new echocardiographic or electrocardiographic abnormalities with greater elevations in cardiac biomarkers among patients requiring ICU care [1, 20] . Case cohort studies included data in patients for whom the outcome and illness course helped further elucidate the role of cardiac injury in COVID-19 disease. cache = ./cache/cord-291687-kwu0otpi.txt txt = ./txt/cord-291687-kwu0otpi.txt === reduce.pl bib === id = cord-292561-iy06b9h9 author = Miesbach, Wolfgang title = COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation date = 2020-07-17 pages = extension = .txt mime = text/plain words = 4889 sentences = 262 flesch = 45 summary = The novel coronavirus infection (COVID-19) is caused by the new coronavirus SARS-CoV-2 and is characterized by an exaggerated inflammatory response that can lead to severe manifestations such as adult respiratory syndrome, sepsis, coagulopathy, and death in a proportion of patients. 5 While most patients show only mild symptoms, 6 a characteristic feature of COVID-19 is that a proportion of patients develop severe complications within a short time after infection, such as adult respiratory syndrome (ARDS) or disseminated intravascular coagulation (DIC), sepsis followed by organ failure, and death. 15 These laboratory changes are consistent with previous studies which showed that hypoalbuminemia, lymphopenia, and C-reactive protein 4 mg/dL were the predictive factors for the progression of pneumonia to respiratory failure in MERS-CoV-infected patients and that elevated lactate dehydrogenase (LDH) levels were associated with hospital-acquired infection with SARS-CoV. cache = ./cache/cord-292561-iy06b9h9.txt txt = ./txt/cord-292561-iy06b9h9.txt === reduce.pl bib === id = cord-291855-wtwz94sy author = Tambone, Vittoradolfo title = Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic date = 2020-06-16 pages = extension = .txt mime = text/plain words = 1149 sentences = 58 flesch = 45 summary = title: Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic According to the above, we propose the following five ethical criteria for the triage of patients in conditions of limited resources, such as the COVID pandemic. It is rooted in the idea of human dignity, which gives birth to the humanitarian imperative conveyed in the first core principle of "disaster medicine"; the common good also means that, in a Global Health framework, patients are not just isolated individuals but persons with strong ties to their communities, and therefore both patient and community need to be taken into account (5); (b) no one must be abandoned or discriminated against for any reason (6); (c) before denying a necessary referral of a patient to an ICU, due to lack of resources, it is required to consider alternatives both for the immediate case and, based on the experience gained, for similar future cases. cache = ./cache/cord-291855-wtwz94sy.txt txt = ./txt/cord-291855-wtwz94sy.txt === reduce.pl bib === id = cord-291873-inzzywps author = Tognetto, Daniele title = Managing ophthalmic practices in a referral emergency COVID‐19 hospital in north‐east Italy date = 2020-06-01 pages = extension = .txt mime = text/plain words = 721 sentences = 48 flesch = 47 summary = To diminish the risk of contamination, some healthcare facilities, included our hospital, were assigned as referral regional care centre for COVID-19 patients. According to our recent experience, we share a series of measures to prevent the nosocomial transmission of the disease and to reduce the risk of contamination for patients, caregivers and administrative staff. The triaging system screens patients through temperature measurements, and a questionnaire about upper respiratory symptoms, fever, myalgia and anosmia, domicile or travelling in hot areas, and contact history with confirmed or suspected COVID-19 patients within the past 14 days. Patients who meet one of these criteria are addressed to a separate controlled circuit to test for COVID-19 positivity. In our practice, patients with an urgent surgical condition (such as retinal detachment, endophthalmitis, open globe trauma and sight-threatening uncontrolled ocular pressure) are first screened for COVID-19. Precautionary measures needed for ophthalmologists during pandemic of the coronavirus disease 2019 (COVID-19) cache = ./cache/cord-291873-inzzywps.txt txt = ./txt/cord-291873-inzzywps.txt === reduce.pl bib === id = cord-292620-t8ocqm6g author = Somani, S. title = Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19 date = 2020-05-22 pages = extension = .txt mime = text/plain words = 2768 sentences = 171 flesch = 48 summary = Methods and Findings: Retrospective cohort study of patients with confirmed SARS-CoV-2 discharged alive from five hospitals in New York City with index hospitalization between February 27th-April 12th, 2020, with follow-up of [≥]14 days. Of 2,864 discharged patients, 103 (3.6%) returned for emergency care after a median of 4.5 days, with 56 requiring inpatient readmission. Patients who returned had higher proportion of COPD and hypertension with shorter LOS on index hospitalization, and a trend towards lower rates of in-hospital treatment-dose anticoagulation. . https://doi.org/10.1101/2020.05.17.20104604 doi: medRxiv preprint Certain index hospitalization laboratory values on discharge differed among patients who returned vs. Finally, returning patients had shorter LOS on index hospitalization with notably a lower frequency of ICU care and inpatient anticoagulation. Among patients discharged following admission for COVID-19, the rate of return to hospital was relatively low, with only half requiring readmission. cache = ./cache/cord-292620-t8ocqm6g.txt txt = ./txt/cord-292620-t8ocqm6g.txt === reduce.pl bib === id = cord-292394-91b3mm6c author = Ashish, A. title = Early CPAP reduced mortality in covid-19 patients. Audit results from Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust. date = 2020-06-02 pages = extension = .txt mime = text/plain words = 1717 sentences = 106 flesch = 57 summary = The use of Continuous Positive Airway Pressure (CPAP) in patients with COVID-19 has now become established as a common clinical practice based on recent experience. Using routinely collected data, the use of CPAP as a supportive non-invasive ventilatory treatment is described in 35 patients with COVID infection. Although the analysis is affected by a small sample size, the results have shown good evidence that supports the early use of CPAP in patients with COVID-19 infection. . https://doi.org/10.1101/2020.05.28.20116152 doi: medRxiv preprint indicates a preference for early CPAP clinical strategy when treating patients with COVID-19. At this early stage in the treatment of COVID-19 respiratory infections the evidence presented supports the early use of CPAP in such patients. Continuous positive airway pressure and noninvasive ventilation in prehospital treatment of patients with acute respiratory failure: a systematic review of controlled studies cache = ./cache/cord-292394-91b3mm6c.txt txt = ./txt/cord-292394-91b3mm6c.txt === reduce.pl bib === id = cord-292493-lx7zfgoi author = Firstenberg, Michael S. title = Isolation protocol for a COVID-2019 patient requiring emergent surgical intervention: case presentation date = 2020-04-19 pages = extension = .txt mime = text/plain words = 2352 sentences = 116 flesch = 50 summary = Few specific guidelines are available to outline the steps necessary to adequately maintain appropriate isolation precautions in patients who require emergent surgical interventions and who are either confirmed SARS-CoV2 or who are awaiting the results of testing. The purpose of this discussion is to outline the steps our U.S. institution undertook in managing a patient who required emergent cardiac surgery for an acute aortic syndrome who was presumptively infected, and did test positive on post-operative day two. Given the findings of pulmonary infiltrates, upon admission, he was placed in strict droplet and contact precautions in a negative air-flow Intensive Care Unit (ICU) room as a potential COVID-2019 case. Written surgical and anesthesia consent was obtained by the operating surgeon and anesthesiologist wearing appropriate personal protective equipment (PPE) that included N-95 mask, face shield, gown, and gloves). cache = ./cache/cord-292493-lx7zfgoi.txt txt = ./txt/cord-292493-lx7zfgoi.txt === reduce.pl bib === id = cord-292335-al6v3b9x author = Crotty, Matthew P. title = Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship date = 2015-11-18 pages = extension = .txt mime = text/plain words = 4443 sentences = 224 flesch = 34 summary = METHOD: This was a single-center retrospective cohort study to evaluate the impact of antibacterials in viral pneumonia on clinical outcomes and subsequent multidrug-resistant organism (MDRO) infections/colonization. CONCLUSION: This study found that long-course antibacterial use in the setting of viral pneumonia had no impact on clinical outcomes but increased the incidence of subsequent MDRO infection/colonization. The relationship between viral and bacterial respiratory infections creates a difficult situation for clinicians determining the appropriate use of antimicrobials as they treat hospitalized patients with pneumonia while also trying to minimize the development and selection of resistant organisms. This study aimed to describe the use of continued empiric antibacterials in patients with known viral pneumonia and to determine the impact of such therapies on subsequent bacterial infections/colonization and clinical outcomes. This study compared a cohort of 174 patients with viral pneumonia and mixed viral-bacterial infection based on exposure to continued empiric antibacterials after respiratory virus identification. cache = ./cache/cord-292335-al6v3b9x.txt txt = ./txt/cord-292335-al6v3b9x.txt === reduce.pl bib === id = cord-292485-vk5xy3zn author = Prasad, Narayan title = The adverse effect of COVID pandemic on the care of patients with kidney diseases in India date = 2020-07-06 pages = extension = .txt mime = text/plain words = 3490 sentences = 180 flesch = 53 summary = We aimed to analyze the effect of lockdown imposed due to COVID-19 pandemic on the care of patients with kidney diseases in India. METHODS: We surveyed 19 major hospitals (8 in public and 11 in private sector) to determine the effect of lockdown on the care of patients with kidney disease, including those on dialysis after the first 3 weeks of lockdown. CONCLUSION: Lack of preparedness before lockdown resulted in an interruption in health care services and posed an immediate adverse effect on the outcome of dialysis and kidney disease patients in India. This survey clearly demonstrates the impact of the COVID-19 pandemic and lockdown on the care of patients with kidney diseases in India, a low-middle income country. In many private hospitals, services were affected due to lockdown restrictions, lack of internal protocols to handle the pandemic, fear of infection to medical staff, and an unwillingness to risk the business from non-COVID patients (22). cache = ./cache/cord-292485-vk5xy3zn.txt txt = ./txt/cord-292485-vk5xy3zn.txt === reduce.pl bib === id = cord-292350-cmrtg91a author = Mondal, Samhati title = Thromboembolic disease in COVID-19 patients: A brief narrative review date = 2020-09-14 pages = extension = .txt mime = text/plain words = 4000 sentences = 207 flesch = 29 summary = Table 1 & 2 summarize the various thrombotic complications noted in COVID-19 patients as published as of June 6 th , 2020 obtained by a literature search on PubMed and EMBASE using combinations of the following MeSH terms: COVID-19, SARS-COV2, novel corona virus, thrombosis, thromboembolic complications, pulmonary embolism. Clinical signs and symptoms of thrombosis such as cutaneous manifestations ("COVID toe") [84] , overt line thrombosis, arterial or venous clots, unexplained increase in oxygen requirement, or organ dysfunction should raise suspicion and prompt further investigation and/or discussion about therapeutic intervention [7] As new information becomes available, it appears increasingly important to routinely monitor platelet count, PT/aPTT, d-dimer, and fibrinogen to assist in anticipating and managing thrombotic complications. ICU patients positive for COVID-19 with elevated d-dimer levels and/or clinico-radiological suspicion for thrombosis as noted above should be considered for therapeutic anticoagulation only after careful assessment of their bleeding risk. cache = ./cache/cord-292350-cmrtg91a.txt txt = ./txt/cord-292350-cmrtg91a.txt === reduce.pl bib === id = cord-292387-2xv3wgaq author = D′Agostino, Armando title = Brief Psychotic Disorder During the National Lockdown in Italy: An Emerging Clinical Phenomenon of the COVID-19 Pandemic date = 2020-08-06 pages = extension = .txt mime = text/plain words = 4555 sentences = 240 flesch = 44 summary = Approximately 2 months after the COVID-19 outbreak in Lombardy and 50 days into national lockdown, we began to hospitalize patients with brief psychotic episodes at a remarkable rate. We report a case series of all consecutive patients admitted to the 2 psychiatric inpatient units of the San Paolo University Hospital who were discharged with a diagnosis of BPD during the COVID-19 pandemic lockdown in Milan, Italy (March 9 to May 18). In order to standardize the evaluation criteria, the following set of instruments was employed: the Brief Psychiatric Rating Scale (BPRS) 20 was performed as a global measure of psychopathology upon admission and at discharge; the presence of stressful life events in the 12 months before the lockdown was assessed using Paykel's interview for recent life events 21 ; the Structured Clinical Interview for DSM (SCID-II) 22 was performed to evaluate the presence of a personality disorder; and the Temperament and Character Inventory-240 items (TCI-240) 23 was administered to investigate personality dimensions. cache = ./cache/cord-292387-2xv3wgaq.txt txt = ./txt/cord-292387-2xv3wgaq.txt === reduce.pl bib === id = cord-292826-lus0tqmi author = Joseph, Tony title = Trauma care in a low-COVID pandemic environment: A new normal date = 2020-06-12 pages = extension = .txt mime = text/plain words = 1267 sentences = 60 flesch = 46 summary = Injury 51 (2020) [1245] [1246] Contents lists available at ScienceDirect Injury journal homepage: www.elsevier.com/locate/injury Editorial Trauma care in a low-COVID pandemic environment: A new normal A pandemic is defined as an outbreak of a disease that spreads quickly over a wide geographical area and infects a high proportion of a population. As we have seen with the current COVID-19 pandemic, some countries have managed to control spread early (eg Taiwan, Singapore, New Zealand and Australia) by immediate action involving physical distancing, widespread testing, contact tracing, isolation of positive cases and supportive treatment. Current recommendations [5] for the management of injured patients in a COVID-19 environment include bypassing the Emergency Department for uncomplicated injuries, minimising invasive procedures, in particular those that are AGPs, and providing surgical treatment that is only absolutely essential. Editorial / Injury 51 (2020) [1245] [1246] The COVID 19 pandemic presents challenges for trauma clinicians with the ongoing risk of virus transmission for both patients and clinical staff which will need to be managed over the coming months or longer. cache = ./cache/cord-292826-lus0tqmi.txt txt = ./txt/cord-292826-lus0tqmi.txt === reduce.pl bib === id = cord-292094-vmsdhccp author = Mandell, Lionel A. title = Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults date = 2007-03-01 pages = extension = .txt mime = text/plain words = 28389 sentences = 1424 flesch = 37 summary = Severity-of-illness scores, such as the CURB-65 criteria (confusion, uremia, respiratory rate, low blood pressure, age 65 years or greater), or prognostic models, such as the Pneumonia Severity Index (PSI), can be used to identify patients with CAP who may be candidates for outpatient treatment. A respiratory fluoroquinolone should be used for penicillin-allergic patients.) Increasing resistance rates have suggested that empirical therapy with a macrolide alone can be used only for the treat-ment of carefully selected hospitalized patients with nonsevere disease and without risk factors for infection with drug-resistant pathogens. Advantages include the high specificity, the ability of some assays to distinguish between influenza A and B, the rapidity with which the results can be obtained, the possibly reduced use of antibacterial agents, and the utility of establishing this diagnosis for epidemiologic purposes, especially in hospitalized patients who may require infection control precautions. cache = ./cache/cord-292094-vmsdhccp.txt txt = ./txt/cord-292094-vmsdhccp.txt === reduce.pl bib === id = cord-293167-3bd3adip author = Nepal, Gaurav title = Neurological manifestations of COVID-19: a systematic review date = 2020-07-13 pages = extension = .txt mime = text/plain words = 5534 sentences = 311 flesch = 44 summary = Most patients infected by SARS-CoV-2 have presented with a mild clinical course: beginning with fever and dry cough, progressing to a form of mild or moderate respiratory disease, and resolving without specific treatment [2] . A retrospective observational study from Wuhan, China, reported that six (2.8%) patients, out of the 214 reviewed COVID-19 cases, developed ischemic stroke. A retrospective observational study from a different center in Wuhan, China, found eleven (5.0%) patients, out of 221 reviewed COVID-19 cases, developed acute ischemic stroke. Those who had COVID-19 infection with new onset of ischemic stroke were more likely to have a severe SARS-CoV-2 presentation, an advanced age (71.6 ± 15.7 years versus 52.1 ± 15.3 years), and preexisting cardiovascular risk factors including hypertension, diabetes, and previous cerebrovascular disease. A retrospective observational study from Wuhan, China, reported one (0.45%) patient, out of 221 reviewed COVID-19 cases, who developed intracerebral hemorrhage. cache = ./cache/cord-293167-3bd3adip.txt txt = ./txt/cord-293167-3bd3adip.txt === reduce.pl bib === id = cord-293285-w8c3ma8l author = Lanza, F title = Reflection on passive immunotherapy in those who need most: some novel strategic arguments for obtaining safer therapeutic plasma or autologous antibodies from recovered COVID ‐19 infected patients date = 2020-05-14 pages = extension = .txt mime = text/plain words = 1503 sentences = 68 flesch = 40 summary = title: Reflection on passive immunotherapy in those who need most: some novel strategic arguments for obtaining safer therapeutic plasma or autologous antibodies from recovered COVID ‐19 infected patients In this mini-report we propose three potential additional options as the source of such autologous Ab and provide some operational arguments, on evidence based to support implementation such strategic approaches urgently for those in need to save lives: a] the use of hyperimmune immunoglobulin concentrates, which derives from plasma of physiologically immunized donors. However, in western countries the use of convalescent plasma and related strategies may become a reality provided that our hospitals will recommend obtaining an informed consent from recovered COVID-infected patients in order to collect and store their FFP and their derived bioproducts. Use of convalescent whole blood or plasma collected from patients recovered from Ebola virus disease for transfusion, as an empirical treatment during outbreaks cache = ./cache/cord-293285-w8c3ma8l.txt txt = ./txt/cord-293285-w8c3ma8l.txt === reduce.pl bib === id = cord-293143-1k170shh author = Dieninghoff, Doris title = Fatal HBoV-1 infection in adult female cystic fibrosis patient date = 2016-07-18 pages = extension = .txt mime = text/plain words = 1752 sentences = 90 flesch = 47 summary = A clinical case of fatal HBoV infection in an adult cystic-fibrosis patient awaiting lung transplantation is reported. A clinical case of fatal HBoV infection in an adult cystic-fibrosis patient awaiting lung transplantation is reported. The human bocavirus (HBoV) is a parvovirus that is associated with acute and chronic infections of the upper and lower respiratory tract, persists in some tissues and solid cancers and putatively may play an aetiologic role in the development of idiopathic lung fibrosis [1] [2] [3] [4] [5] [6] [7] [8] . To date, no animal model exists, thus studies on the pathology of HBoV infections are limited to clinical studies, case descriptions, and air-liquid interface cell culture models that have been shown to mimic some important steps of the infection cycle [1, 7, [10] [11] [12] . cache = ./cache/cord-293143-1k170shh.txt txt = ./txt/cord-293143-1k170shh.txt === reduce.pl bib === id = cord-293333-mqoml9o5 author = Scharbarg, Emeric title = From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves date = 2020-10-03 pages = extension = .txt mime = text/plain words = 5785 sentences = 330 flesch = 59 summary = The second local model refers to a single node of the health system network, i.e. it models the flows of patients with a smaller granularity at the level of a regional hospital care center for COVID-19 infected patients. In particular apart the high transmission rate, other two aspects were immediately pointed out by the physicians which did strongly influence the diffusion of the disease and the medical resources: first it was estimated that a large delay of time (10 to 14 days) is present between the moment in which a person becomes infected and can infect, and the instant in which symptoms become evident and the person is isolated and sent to quarantine. The subsystem (2) consisting by I q , R and D q is then further discussed in Section 4: a group of people who are aware of their infection define the flow of admissions in a local hospital and are split into two populations, the patients admitted in conventional hospitalization and the patients admitted in intensive care. cache = ./cache/cord-293333-mqoml9o5.txt txt = ./txt/cord-293333-mqoml9o5.txt === reduce.pl bib === id = cord-293575-h3wc7j4v author = Adrish, Muhammad title = Association of smoking status with outcomes in hospitalised patients with COVID-19 date = 2020-10-05 pages = extension = .txt mime = text/plain words = 2658 sentences = 181 flesch = 55 summary = Univariate Cox model for survival analysis by smoking status showed that among smokers only current smokers had higher risk of death compared with never smokers (HR 1.61, 95% CI 1.22 to 2.12, p<0.001). CONCLUSION: In our large single-centre retrospective database of patients hospitalised with COVID-19, smoking was associated with development of critical illness and higher likelihood of death. Our hospital is located in New York City where 13.1% of the Key Messages ► Does the smoking status affect outcomes of hospitalised patients with COVID-19. We included adult patients (aged 18 and above) with known smoking status who were hospitalised with COVID-19 for whom severity of illness could be established and had final disposition status at the time of the study. Use of tocilizumab was suggested in patients with evidence of disease progression (defined as worsening respiratory status or radiographic findings) and increasing inflammatory markers early in their acute COVID-19 illness. cache = ./cache/cord-293575-h3wc7j4v.txt txt = ./txt/cord-293575-h3wc7j4v.txt === reduce.pl bib === id = cord-293180-f1ulk9ce author = Li, R W K title = Severe Acute Respiratory Syndrome (SARS) and the GDP. Part II: Implications for GDPs date = 2004-08-14 pages = extension = .txt mime = text/plain words = 4289 sentences = 295 flesch = 51 summary = Special management protocols and modified measures that regulate droplet and aerosol contamination in a dental setting have to be introduced and may include the reduction or avoidance of droplet/aerosol generation, the disinfection of the treatment field, application of rubber dam, pre-procedural antiseptic mouthrinse and the dilution and efficient removal of contaminated ambient air. In the first part of this two-part article an account of the epidemiology, virology, pathology and management of Severe Acute Respiratory Syndrome (SARS) was provided together with public health issues and general aspects of infection control. On the other hand smaller droplets (or aerosols, generally under 10 µm in size) or small-particle residue of evaporated droplets are usually airborne and are entrained in the air for a lengthy period • SARS is a highly infectious disease and dental personnel are likely to be at risk because of the nature of their profession, working in close proximity to the patient. cache = ./cache/cord-293180-f1ulk9ce.txt txt = ./txt/cord-293180-f1ulk9ce.txt === reduce.pl bib === id = cord-292952-z7ajsf2r author = Wong, Anselm title = COVID‐19 and toxicity from potential treatments: Panacea or poison date = 2020-05-12 pages = extension = .txt mime = text/plain words = 1425 sentences = 97 flesch = 53 summary = One of the repercussions of promotion of medications/treatments prior to the results of large robust clinical trials being available is that people may start to self-medicate and potentially overdose. As emergency doctors, we need to be able to tease out the disease process of COVID-19 from potential side effects of trial medications or overdose of these. A small (n = 42), non-randomised open label trial showed decreased viral load in patients receiving hydroxychloroquine (600 mg daily for 10 days) and azithromycin. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected data to emulate a target trial Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial cache = ./cache/cord-292952-z7ajsf2r.txt txt = ./txt/cord-292952-z7ajsf2r.txt === reduce.pl bib === id = cord-293522-gg706q8s author = Toumi, Mondher title = Commentary on “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial” by Gautret et al date = 2020-05-13 pages = extension = .txt mime = text/plain words = 5234 sentences = 277 flesch = 51 summary = title: Commentary on "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial" by Gautret et al The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were recently published by Philippe Gautret et al. This study provides outstanding results for the combination of hydroxychloroquine and azithromycin over the standard of care, but the evidence was deemed insufficiently robust to warrant a public health decision to widen the use of hydroxychloroquine for the treatment of COVID-19. The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were published in the International Journal of Antimicrobial Agents by Philippe Gautret et al. The US Centers for Disease Control and Prevention provides information on the use of hydroxychloroquine and chloroquine in the USA to treat coronavirus 2infected patients. cache = ./cache/cord-293522-gg706q8s.txt txt = ./txt/cord-293522-gg706q8s.txt === reduce.pl bib === id = cord-293570-gh6ykmea author = Gupta, Rajib K. title = Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease: a report of 2 cases date = 2020-08-04 pages = extension = .txt mime = text/plain words = 3479 sentences = 201 flesch = 52 summary = Renal biopsy findings in hospitalized COVID-19 patients presenting solely with acute kidney injury (AKI) have recently been described in published literature in few case reports. We herein describe two cases where the patients presented primarily with nephrotic syndrome with a temporal association with COVID-19; the two renal biopsies showed two different histologic lesions on light microscopy (at least on initial biopsy) with diffuse podocytopathy as the sole ultrastructural lesion for both cases. BP was controlled to 128/84 mmHg. Follow-up: Two subsequent COVID-19 RT-PCR tests came back negative on the 4th and the 5th of May. He was commenced on oral prednisone 60 mg a day on the 8th of May. Unfortunately, there was no response to high-dose steroids and the patient continued to have nephrotic-range proteinuria and worsening renal function. cache = ./cache/cord-293570-gh6ykmea.txt txt = ./txt/cord-293570-gh6ykmea.txt === reduce.pl bib === id = cord-293086-6282sb6b author = Liddell, Kathleen title = Who gets the ventilator? Important legal rights in a pandemic date = 2020-05-11 pages = extension = .txt mime = text/plain words = 5502 sentences = 268 flesch = 48 summary = 2 As a result, at present, the only central guidance comes from the 'COVID-19 Rapid Guideline' issued by the National Institute for Health and Care Excellence (NICE), which recommends triaging admission to the ICU based on frailty assessments, but provides little concrete guidance on how to allocate or re-allocate ventilators once a patient is in the ICU. At present, the prognostic tools required to produce an effective decision support system (triage protocol) are lacking along with most of the infrastructure, processes, legal protections, and training for critical care triage.' 13 It is difficult to attribute relative probabilities of survival to patients, or to anticipate length of bed stay, with a novel disease like COVID-19. Thus, if ventilation is clinically indicated, it is doubtful that doctors can Current controversy unilaterally decide to withhold care on the grounds that a scarce resource would be more effectively used on future (anticipated) patients. cache = ./cache/cord-293086-6282sb6b.txt txt = ./txt/cord-293086-6282sb6b.txt === reduce.pl bib === id = cord-293730-dlqo6fep author = Caratozzolo, Salvatore title = The impact of COVID-19 on health status of home-dwelling elderly patients with dementia in East Lombardy, Italy: results from COVIDEM network date = 2020-09-12 pages = extension = .txt mime = text/plain words = 3723 sentences = 179 flesch = 47 summary = Information on age, sex, education, clinical characteristics including dementia diagnosis, dementia severity by Clinical Dementia Rating scale (CDR) [6] , Mini Mental State Examination (MMSE) [7] , and Basic Activity of Daily Life (BADL) [8] , walking, total number of chronic diseases and type of diseases among a pre-defined list (hypertension, COPD, renal disease, heart disease, cancer, gastrointestinal diseases, hepatic disease, diabetes, thyroid disorders, arthritis), number of drugs, and flu vaccination were obtained from previous medical records based on the last recorded visit at CDCD. Findings from our study showed that COVID-19 affected over 10% of home-dwelling older patients with dementia who showed high risk of adverse outcomes, such as unplanned hospitalization and mortality. Findings of this study are in line with previous reports [10] [11] [12] and add new insight by showing that COVID-19 exerted a relevant impact on health status of home-dwelling elderly patients with dementia determining a high rate of hospitalization and mortality. cache = ./cache/cord-293730-dlqo6fep.txt txt = ./txt/cord-293730-dlqo6fep.txt === reduce.pl bib === id = cord-294057-fbox3a5q author = Schlegl, Sandra title = Bulimia nervosa in times of the COVID‐19 pandemic—Results from an online survey of former inpatients date = 2020-08-07 pages = extension = .txt mime = text/plain words = 2812 sentences = 149 flesch = 53 summary = It was divided into seven parts: (a) Sociodemographic and other information such as age, sex, current self-reported height and weight, occupational situation during the COVID-19 pandemic, and contact history with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that is, current or previous own confirmed infection or infection of others (yes/no answers); (b) Overall impact of the COVID-19 pandemic on ED symptoms and general well-being, that is, deterioration of symptomatology and quality of life, adverse effects on therapy, incidence of new symptoms (5-point scale with 1 = strongly agree to 5 = strongly disagree); (c) Worries, for example, regarding infections, relapses, food insecurity, finances, and job (5-point scale with 1 = extremely worried to 5 = not at all worried); (d) General psychopathology and interpersonal conflicts (5-point scale with 1 = significantly worsened to 5 = significantly improved); (e) Specific ED symptoms and behaviours (5-point scale from 1 = significantly worsened/much more to 5 = significantly improved/much less); (f) Health care utilisation before and during the COVID-19 pandemic (yes/no answers); (g) Use and helpfulness of strategies as suggested by Fernandez-Aranda et al. cache = ./cache/cord-294057-fbox3a5q.txt txt = ./txt/cord-294057-fbox3a5q.txt === reduce.pl bib === id = cord-293964-hz5uow2b author = Hermann, Matthias title = Feasibility and Efficacy of Cardiopulmonary Rehabilitation following COVID-19 date = 2020-07-22 pages = extension = .txt mime = text/plain words = 2728 sentences = 163 flesch = 46 summary = Infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2), hereafter referred as COVID-19, often affects patients with chronic health conditions and takes a more severe course in patients with comorbidities such as cardiovascular disease, diabetes mellitus, and obesity. Within two days after admission for rehabilitation all patients were assessed with questionnaires, such as Chronic Respiratory Questionnaire (CRQ), Hospital Anxiety and Depression Scale (HADS), and Cumulative Illness Rating scale (CIRS) and Functional Independence Measure (FIM). To measure changes during rehabilitation, functional assessments with 6-minute walk test (6-MWT) and Feeling Thermometer (FT) were performed on admission and before discharge. Exercise capacity was measured at hospital admission and discharge using the 6-min walk test (6-MWT), performed once at the beginning and once at the end of the CR program after 20 days, according to the guidelines of the American Thoracic Society (ATS) and carried out by experienced, well-instructed examiners. cache = ./cache/cord-293964-hz5uow2b.txt txt = ./txt/cord-293964-hz5uow2b.txt === reduce.pl bib === id = cord-294487-hcuzxhb3 author = Shenoi, Susan title = Telemedicine in pediatric rheumatology: this is the time for the community to embrace a new way of clinical practice date = 2020-10-31 pages = extension = .txt mime = text/plain words = 2102 sentences = 122 flesch = 37 summary = The current COVID 19 global pandemic has forced a paradigm shift with many centers rapidly adopting virtual visits to conduct care resulting in rapid expansion of use of telemedicine amongst practices. BODY: This commentary discusses practical tips for physicians including guidance around administrative and governance issues, preparation for telemedicine, involving the multidisciplinary care team, and teaching considerations. CONCLUSION: This commentary provides a starting framework for telemedicine use in pediatric rheumatology and further work on validation and acceptability is needed. Virtual care models with remote clinics and video visits (e-visits or telemedicine) have become widespread practice overnight. This commentary describes practical creative approaches based on our experiences and discusses the potential for telemedicine to address unmet needs in the wider context of pediatric rheumatology. Young patients (< 3 years) are more challenging to keep on task with a virtual joint exam, but a care-giver only visit to discuss symptoms or medication side effects is often feasible. Decreasing patient cost and travel time through pediatric rheumatology telemedicine visits cache = ./cache/cord-294487-hcuzxhb3.txt txt = ./txt/cord-294487-hcuzxhb3.txt === reduce.pl bib === id = cord-294073-65h2mkdy author = Ke, Jia title = Strategies and recommendations for the management of gastrointestinal surgery during the COVID-19 pandemic: experience shared by Chinese surgeons date = 2020-07-03 pages = extension = .txt mime = text/plain words = 4150 sentences = 234 flesch = 43 summary = We also recommend that each hospital should establish a group of diagnostic experts with responsibilities for risk stratification, especially for patients under investigation who need urgent surgery. • It is known that fever is one of the most common symptoms of COVID-19 and that patients with certain GI diseases (e.g. acute appendicitis, gastric perforation, intestinal obstruction) who required urgent care with emergency GI surgery often present with high fever as well. COVID-19-positive patients with GI bleeding with hemodynamic stability should undergo conservative treatments first, including angioembolization, before endoscopic treatment due to the high risk of endoscopy being an aerosol-generating procedure. For confirmed/high-risk COVID-19 patients and PUIs, diagnostic and therapeutic GI endoscopies should be performed in a negative-pressure room with Level Three precautions. For all surgical personnel involved in GI surgery for confirmed/ high-risk COVID-19 patients or for PUIs for COVID-19, we recommend the following protective measures (Figure 1 ). cache = ./cache/cord-294073-65h2mkdy.txt txt = ./txt/cord-294073-65h2mkdy.txt === reduce.pl bib === id = cord-292856-7hjzzxtm author = Viasus, Diego title = Influenza A(H1N1)pdm09-related pneumonia and other complications date = 2012-10-31 pages = extension = .txt mime = text/plain words = 4215 sentences = 294 flesch = 34 summary = The main complications reported in hospitalized adults with influenza A(H1N1)pdm09 were pneumonia (primary influenza pneumonia and concomitant/secondary bacterial pneumonia), exacerbations of chronic pulmonary diseases (mainly chronic obstructive pulmonary disease and asthma), the need for intensive unit care admission (including mechanical ventilation, acute respiratory distress syndrome and septic shock), nosocomial infections and acute cardiac events. The main complications reported in hospitalized adults with influenza A(H1N1)pdm09 were pneumonia (primary influenza pneumonia and concomitant/secondary bacterial pneumonia), exacerbations of chronic pulmonary diseases (mainly chronic obstructive pulmonary disease and asthma), the need for intensive unit care admission (including mechanical ventilation, acute respiratory distress syndrome and septic shock), nosocomial infections and acute cardiac events. 6, 34, 35 Chronic pulmonary diseases, mainly COPD and asthma, are frequent comorbidities reported in hospitalized patients with influenza A(H1N1)pdm09 virus infection. cache = ./cache/cord-292856-7hjzzxtm.txt txt = ./txt/cord-292856-7hjzzxtm.txt === reduce.pl bib === id = cord-293547-29i3u83s author = Pfaar, O title = COVID‐19 pandemic: Practical considerations on the organization of an allergy clinic – an EAACI/ARIA Position Paper date = 2020-06-12 pages = extension = .txt mime = text/plain words = 8811 sentences = 512 flesch = 42 summary = RESULTS: Based on diagnostic and treatment standards developed by EAACI, on international information regarding COVID‐19, on guidelines of the World Health Organization (WHO) and other international organizations as well as on previous experience, a panel of experts including clinicians, psychologists, IT experts and basic scientists along with EAACI and the "Allergic Rhinitis and its Impact on Asthma (ARIA)" inititiative have developed recommendations for the optimal management of allergy clinics during the current COVID‐19 pandemic. CONCLUSIONS: This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients whilst ensuring necessary safety in the current COVID‐19 pandemic. In the current SARS-CoV-2 pandemic, the European Task Force on Atopic Dermatitis (ETFAD) recommends to continue all immune-modulating treatment since exacerbations of underlying diseases can have a large negative impact on the patient's immunity [30] . cache = ./cache/cord-293547-29i3u83s.txt txt = ./txt/cord-293547-29i3u83s.txt === reduce.pl bib === id = cord-294336-fqobpo47 author = Soy, Mehmet title = Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic date = 2020-06-25 pages = extension = .txt mime = text/plain words = 5792 sentences = 279 flesch = 38 summary = This paper aims to review the pathogenesis and the clinical picture of HLH, and its severe complication, the cytokine storm, with a special emphasis on the developed classification criteria sets for rheumatologists, since COVID-19 infection has clinical symptoms resembling those of the common rheumatologic conditions and possibly triggers HLH. Hemophagocytic lymphohistiocytosis (HLH) comprises two different conditions that may be difficult to distinguish from one another: A primary form that occurs due to genetic disorders and a secondary form that is triggered by various infections, autoimmune/autoinflammatory diseases, or chemicals [1, 2] . In this review, we aim to contribute to the rheumatologists' awareness of the life-threatening rare complication of HLH, the cytokine storm, to prevent a possible misdiagnosis in the presence of the clinical and laboratory features of COVID-19 resembling or mimicking to that of an underlying or a new-onset rheumatological condition. cache = ./cache/cord-294336-fqobpo47.txt txt = ./txt/cord-294336-fqobpo47.txt === reduce.pl bib === id = cord-294108-uvnh0s9r author = Dube, Taru title = Repurposed Drugs, Molecular Vaccines, Immune‐Modulators, and Nanotherapeutics to Treat and Prevent COVID‐19 Associated with SARS‐CoV‐2, a Deadly Nanovector date = 2020-10-25 pages = extension = .txt mime = text/plain words = 13885 sentences = 845 flesch = 44 summary = [2, [8] [9] [10] This article discusses SARS-CoV-2 nanostructure, the virus biology in connection to its epidemiology, clinical manifestations, and potential and future therapeutic options including repurposed drugs, vaccine/protein therapies, immune therapies, and nanotherapeutics. Mechanisms such as inhibition of viral enzymes (DNA and RNA polymerases, 3CL pro, TMPRSS2, reverse transcriptase, neuraminidase, endonucleases, and other proteases) or processes such as ACE2 cellular receptor inhibitors and endosomal acidification mediators prohibiting viral fusion; molecules interfering with glycosylation of the viral protein, viral assembly, new viral particle transport, and release, and immunomodulation of cytokine release can be potential targets in developing various antiviral drugs for the SARS-CoV-2. [85] A randomized, placebo-controlled, Phase IV clinical trial assessing the safety and efficacy of umifenovir as an adjuvant therapy to the combined therapeutic regimen of IFN 1a, lopinavir/ritonavir and hydroxychloroquine in moderate to severe COVID-19 patients (NCT04350684) is underway. cache = ./cache/cord-294108-uvnh0s9r.txt txt = ./txt/cord-294108-uvnh0s9r.txt === reduce.pl bib === id = cord-293852-r72c6584 author = Greco, S. title = Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era date = 2020-10-31 pages = extension = .txt mime = text/plain words = 8163 sentences = 468 flesch = 40 summary = Different studies found that the values of cardiac Troponins were increased in COVID-19 patients with more severe disease [4, 5, [68] [69] [70] , indicating an association of SARS-CoV-2 with myocardial damage. Moreover, the single-cell RNA-sequencing (scRNAseq) approach has been used to profile the SARS-CoV-2 host-response in the PBMCs of COVID-19 patients, and to comprehensively characterize the immunological changes [124] [125] [126] [127] [128] [129] [130] . However, SARS-CoV-2 infection of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) induced cytotoxic effects and RNA-seq findings highlighted significant transcriptional changes in gene pathways related to cellular metabolism and immune response [131] [132] [133] . This analysis also revealed several host-derived lncRNAs differentially expressed in COVID-19 patient-derived lung tissue, and in SARS-CoV-2 infected epithelial cells, including MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) and NEAT1 (nuclear-enriched autosomal transcript 1) [151] (Fig. 5) . cache = ./cache/cord-293852-r72c6584.txt txt = ./txt/cord-293852-r72c6584.txt === reduce.pl bib === id = cord-293472-d3iwlpsr author = Afilalo, Marc title = Evaluation and Management of Seasonal Influenza in the Emergency Department date = 2012-04-06 pages = extension = .txt mime = text/plain words = 9919 sentences = 516 flesch = 38 summary = During influenza season (testing should be done in the following persons if the result will influence clinical management) Outpatient immunocompetent persons of any age at high risk of developing influenza complications (eg, hospitalization or death) presenting with acute febrile respiratory symptoms 5 days or less after illness onset (when virus is usually being shed) Outpatient immunocompromised persons of any age presenting with febrile respiratory symptoms, irrespective of time since illness onset (because immunocompromised persons can shed influenza viruses for weeks to months) Hospitalized persons of any age (immunocompetent or immunocompromised) with fever and respiratory symptoms, including those with a diagnosis of community-acquired pneumonia, irrespective of time since illness onset Elderly persons and infants presenting with suspected sepsis or fever of unknown origin, irrespective of time since illness onset Children with fever and respiratory symptoms presenting for medical evaluation, irrespective of time since illness onset Persons of any age who develop fever and respiratory symptoms after hospital admission, irrespective of time since illness onset Immunocompetent persons with acute febrile respiratory symptoms who are not at high risk of developing complications secondary to influenza infection may be tested for purposes of obtaining local surveillance data cache = ./cache/cord-293472-d3iwlpsr.txt txt = ./txt/cord-293472-d3iwlpsr.txt === reduce.pl bib === id = cord-294270-do6i6ymq author = Banu, Buyukaydin title = Pneumonia date = 2019-11-29 pages = extension = .txt mime = text/plain words = 7319 sentences = 426 flesch = 37 summary = A population-based cohort study with 46,237 elderly patients found that immunosuppression, COPD, smoking, congestive heart failure, diabetes, malignancy, and previous hospitalizations for pneumonia are independent risk factors for developing the disease in this age group (Barlow et al., 2007) . Presence of comorbidities such as chronic heart, lung, liver or renal disease; diabetes mellitus; alcoholism; malignancies; asplenia; immunosuppressing conditions or use of immunosuppressing drugs; or use of antimicrobials within the previous 3 months A respiratory fluoroquinolone (moxifloxacin, gemifloxacin, or levofloxacin [750 mg]) (strong recommendation) (1 point) ATS, American Thoracic Society; CAP, community-acquired pneumonia; ICU, ıntensive care unit; IDST, Infectious Diseases Society of America; PIRO, predisposition, infection, response and organ dysfunction score; PS CURXO80, pH, systolic blood pressure, confusion, urea nitrogen, respiratory rate, x-ray finding, oxygen arterial pressure and age of 80 years or more; SMART-COP, systolic blood pressure, multilobar chest radiography, albumin level, respiratory rate, tachycardia, confusion, oxygenation and pH; BUN, blood urea nitrogen; WBC, white blood cell. cache = ./cache/cord-294270-do6i6ymq.txt txt = ./txt/cord-294270-do6i6ymq.txt === reduce.pl bib === id = cord-294184-jte9xx5e author = Macleod, Jack title = Surgery during COVID-19 crisis conditions: can we protect our ethical integrity against the odds? date = 2020-06-12 pages = extension = .txt mime = text/plain words = 2742 sentences = 175 flesch = 48 summary = Careful consideration of ethical principles must guide production of local guidance ensuring consistent patient selection thus preserving equality as well as quality of clinical services. As a surgical department operating under COVID-19 (severe acute respiratory syndrome coronavirus 2) crisis conditions, a multitude of ethical, practical and medical dilemmas are encountered. Coupling the unclear risk profile of COVID-19 with a lack of alternatives to provide the gold standard surgery, what is the ethical justification for performing a substitute procedure on this cohort of patients? hoW CAn We eThICAlly proVIde The TrAdITIonAl gold sTAndArd, or AlTernATIVe, operATIon To pATIenTs durIng The CoVId-19 CrIsIs? One such framework has formed the basis of healthcare ethics: initially proposed by Beauchamp and Childress in 1979, the four principles of patient care are beneficence, non-maleficence, respect for autonomy and justice. For those patients requiring acute treatment, an alternative to the conventional gold standard can be performed if its known inferiority is outweighed by the reduced risk of COVID-19-related complications. cache = ./cache/cord-294184-jte9xx5e.txt txt = ./txt/cord-294184-jte9xx5e.txt === reduce.pl bib === id = cord-293634-4rryqbnu author = Rosen, Kelsey title = Delivering Telerehabilitation to COVID-19 Inpatients:A Retrospective Chart Review Suggests It Is a Viable Option date = 2020-07-16 pages = extension = .txt mime = text/plain words = 3592 sentences = 185 flesch = 34 summary = Based on the algorithm, COVID-19 inpatients were selected to receive telerehabilitation if they could ambulate independently, could use technology, had stable vital signs, required minimal supplemental oxygen, and were cognitively intact. The purpose of the inpatient telerehabilitation PT program for COVID-19 patients was to safely assess barriers to discharge, deliver patient education, and provide a home exercise program (HEP) all while minimizing staff exposure. Success of the inpatient telerehabilitation program was determined based on the ability to create an algorithm, train staff, deliver education efficiently, maintain patient and staff safety during interventions, and ensure patients discharged home safely. Despite these limitations, we believe that this retrospective review provides preliminary data on how to implement an inpatient telerehabilitation program and suggests that selected COVID-19 patients can be discharged successfully after this method of treatment. cache = ./cache/cord-293634-4rryqbnu.txt txt = ./txt/cord-293634-4rryqbnu.txt === reduce.pl bib === id = cord-294349-ps3qlho2 author = Al-Sharif, Eman title = Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye date = 2020-09-03 pages = extension = .txt mime = text/plain words = 7053 sentences = 340 flesch = 43 summary = PURPOSE: Several studies have reported conflicting results on ocular manifestations and transmission of coronavirus disease 2019 (COVID-19) whose causative virus, SARS-CoV-2, belongs to the coronavirus family, the seventh recognized as a human pathogen and the third causing a severe clinical syndrome. Coronavirus disease 2019, known as COVID-19, is an emerging infection which is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that was first reported in Wuhan city, China, late in December 2019 [4] . Clinical ocular manifestations were absent in all SARS-CoV-1 patients, and viral RNA was detected in the conjunctival secretions and tears in three cases out of 120 (2.5%) with a range of 0-8% [6] [7] [8] [9] . Similarly, a small study testing the conjunctival secretions and tears (collected twice over 2-3 days) of 30 confirmed COVID-19 patients demonstrated the presence of viral RNA (in both samples) in one patient only who also showed clinical signs of conjunctivitis [12] . cache = ./cache/cord-294349-ps3qlho2.txt txt = ./txt/cord-294349-ps3qlho2.txt === reduce.pl bib === id = cord-294443-w6p3f5qc author = Nadar, Sunil K. title = Managing hypertension during the COVID-19 pandemic date = 2020-05-14 pages = extension = .txt mime = text/plain words = 1642 sentences = 82 flesch = 48 summary = Concern was therefore raised at the start of the pandemic that ACE inhibitors and angiotensin receptor blockers (ARBs), medications that are commonly used for hypertension and heart failure, could have a potential deleterious effect [11] , as ACE2 is widely expressed in the cardiovascular system and is up regulated by these drugs in some tissues in a subset of animal models [12, 13] . Subsequent data have raised the possibility that patients treated with ACE inhibitors or ARBs do indeed have a better outcome, with the crucial caveat that the possibility of unmeasured confounding and bias precludes drawing cause-effect conclusions from the clinical studies available thus far. A recent retrospective study from China comparing outcomes on hospitalised patients with COVID-19 with and without ACE inhibitors or ARBs for hypertension has suggested that in the former all-cause mortality was lower (adjusted HR, 0.42; 95% CI, 0.19-0.92; P = 0.03) [18] . Retrospective study of risk factors for severe SARS-Cov-2 infections in hospitalized adult patients. cache = ./cache/cord-294443-w6p3f5qc.txt txt = ./txt/cord-294443-w6p3f5qc.txt === reduce.pl bib === id = cord-294617-i8j36bol author = Dhar, Shabir A title = My fear, my morals: a surgeon’s perspective of the COVID crisis date = 2020-10-14 pages = extension = .txt mime = text/plain words = 1915 sentences = 134 flesch = 65 summary = Initially the surgical specialties had a marginal role in the patient care, but as the timeline has expanded, the surgeon is being increasingly called upon to participate in this prolonged tussle [1] . Questions about the pandemic enforced surgical prioritization and the potential problems that the patient might face due to the delay, down the line, continue to challenge our ethical principles. The dominant view in ethics literature is that no individual health professional has a specific positive obligation to treat a patient when doing so places the professional at risk. As the authorities develop and change their policies especially regarding the management of COVID positive pregnant patients, our obstetric surgeons feel as if they are riding an emotional roller coaster. Ethics for surgeons during the COVID-19 pandemic; review article Your country needs you?' the ethics of allocating staff to high risk clinical roles in the management of patients with COVID-19 cache = ./cache/cord-294617-i8j36bol.txt txt = ./txt/cord-294617-i8j36bol.txt === reduce.pl bib === id = cord-293922-knzv4jvj author = Zuo, Y. title = Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients date = 2020-09-02 pages = extension = .txt mime = text/plain words = 3049 sentences = 202 flesch = 48 summary = Results: We found markedly elevated levels of tPA and PAI-1 among patients hospitalized with COVID-19. Conclusion: While both tPA and PAI-1 are elevated among COVID-19 patients, extremely high levels of tPA enhance spontaneous fibrinolysis and are significantly associated with mortality in some patients. These data indicate that fibrinolytic homeostasis in COVID-19 is complex with a subset of patients expressing a balance of factors that may favor fibrinolysis and suggests that further study of tPA as a potential biomarker is warranted. Utilizing established Luminex platforms, we measured total PAI-1 and tPA levels in the plasma of 118 patients hospitalized with COVID-19 and 30 healthy controls. Elevated PAI-1 and its associated hypofibrinolytic state were observed in the 2002 SARS-CoV epidemic [22] , while recent characterizations of COVID-19 patients have suggested impaired global fibrinolysis [16, 23] . Interestingly, in our large cohort of hospitalized COVID-19 patients, we observed elevated levels of not only PAI-1, but also tPA. cache = ./cache/cord-293922-knzv4jvj.txt txt = ./txt/cord-293922-knzv4jvj.txt === reduce.pl bib === id = cord-294139-78c5h7la author = Yamakawa, Mai title = Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis date = 2020-08-29 pages = extension = .txt mime = text/plain words = 3096 sentences = 171 flesch = 45 summary = The frequency of common comorbidities (hypertension, dyslipidemia, diabetes mellitus, acute coronary syndrome /coronary artery disease), atrial fibrillation, stroke/transient ischemic attack, and malignancy), etiology of stroke if specified in the articles, and treatment (tissue plasminogen activator (tPA), mechanical thrombectomy, and anticoagulation were calculated by summation of events divided by the number of total patients from all studies whose information is available for each value. The salient findings of the study can be summarized as the followings; (1) the frequency of stroke in hospitalized COVID-19 patients was 1.1%, with mean days from COVID-19 symptom onset to stroke at 8 days, most commonly cryptogenic; (2) even with early case series with younger patients without a pre-existing medical condition, the mean age was 66.6, with slight male preponderance (65.6%); (3) stroke risk factors such as hypertension, dyslipidemia, and prior strokes were common as comorbidities; altered mental status was as frequent as 51.4 % as presenting symptom of stroke; (4) elevation of d-dimer and CRP were reproduced after synthesis of results; (5) case fatality rate was as high as 44.2% in patients with COVID-19 and stroke. cache = ./cache/cord-294139-78c5h7la.txt txt = ./txt/cord-294139-78c5h7la.txt === reduce.pl bib === id = cord-293704-tnik6sd3 author = Tey, Jeremy title = Navigating the challenges of the COVID-19 outbreak: perspectives from the radiation oncology service in singapore date = 2020-03-31 pages = extension = .txt mime = text/plain words = 3512 sentences = 220 flesch = 51 summary = There is a higher risk of mortality of COVID-19 in cancer patients and hence unique considerations for a radiation oncology department operating in an infectious disease outbreak. There is a higher risk of mortality of COVID-19 in cancer patients and hence unique considerations for a radiation oncology department operating in an infectious disease outbreak. This includes interventions, business continuity plans and workflow in managing a COVID-19 positive patient on radiotherapy. With the evolving COVID-19 outbreak, there needs to be provisions and policies to ensure continuity of radiation oncology services. There should be provisions within the department such that continuity of radiation oncology services will not be impacted as there is possibility of staff managing confirmed cases and therefore needs to be self-quarantined at home. Nonetheless, radiation oncology departments can act to better position themselves to continue radiotherapy services in the face of resource limitations brought on by the outbreak, as well as to protect staff and patients. cache = ./cache/cord-293704-tnik6sd3.txt txt = ./txt/cord-293704-tnik6sd3.txt === reduce.pl bib === id = cord-295123-x2gxgave author = Zhou, Wei title = Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia date = 2020-02-21 pages = extension = .txt mime = text/plain words = 1705 sentences = 77 flesch = 36 summary = However, according to the Chinese government's daily report, 13.2-21.3% of patients with 2019-nCoV infection developed into severe or fatal illness (Fig. S1a ), which is characterized by the rapid development to acute respiratory distress syndrome (ARDS) or septic shock. On February 7, 2020, the China's National Health Commission released the fifth trial version of Diagnosis and Treatment Scheme for Pneumonitis with 2019-nCoV Infection, and provided a systematic treatment strategy for severe cases. Some scholars may not support the corticosteroids treatment for novel coronavirus pneumonia (NCP), because observational studies and systematic reviews have indicated inconclusive clinical evidence on the effect of corticosteroids therapy for viral pneumonias (such as SARS, MERS and H1N1). Evidently, all these results strongly suggest that proper use of low-dose corticosteroids may bring survival advantages for critically ill patients with 2019-nCoV, but this treatment should be strictly performed on NCP patients with definite clinical indications (such as refractory ARDS, sepsis or septic shock) according to the recommended guidelines. cache = ./cache/cord-295123-x2gxgave.txt txt = ./txt/cord-295123-x2gxgave.txt === reduce.pl bib === id = cord-294636-xes8g0x4 author = Brindle, Mary E. title = Approaching Surgical Triage During the COVID-19 Pandemic date = 2020-05-07 pages = extension = .txt mime = text/plain words = 2133 sentences = 134 flesch = 50 summary = The harm caused by failure to modify the surgery schedule has been clearly demonstrated in countries like China where ongoing elective operations and nonessential clinic visits contributed to early rates of in-hospital COVID-19 transmission 2 ; and from Italy where resources consumed through elective surgery including personal protective equipment left health care workers vulnerable when the pandemic crested. Although nonoperative care of appendicitis may have a failure rate between 14 and 30%, the majority of patients will get out of hospital without surgery and will not consume the human and material resources that are most needed in COVID-19 management. 9. COVID-19 surgical care pathways and a COVID-19 Operating room will need to be maintained after the peak of the pandemic has passed as patients with COVID-19 will continue to present with conditions requiring surgery. cache = ./cache/cord-294636-xes8g0x4.txt txt = ./txt/cord-294636-xes8g0x4.txt === reduce.pl bib === id = cord-294294-66udu5y4 author = Bullock, Travis S. title = Outpatient surgery in patients with ankle fractures minimises hospital admissions and utilisation of healthcare resources date = 2020-08-08 pages = extension = .txt mime = text/plain words = 3192 sentences = 170 flesch = 41 summary = CONCLUSION: Strategic outpatient management of acute closed ankle fractures is associated with acceptable rates of unplanned emergency department visits, hospital readmissions, and SSIs. In the context of the recent SARS-CoV-2 outbreak, outpatient management of these injuries may aide in the mitigation of nosocomial infections and the preservation of finite healthcare resources. Our study data shows that outpatient surgical fixation represents a reasonable approach to these injuries, as we demonstrated acceptable rates of unplanned ED visits, hospital readmissions, and SSIs. Based on these findings, we suggest that a safe and properly implemented outpatient protocol may be beneficial in mitigating the risk of inpatient viral transmission, safeguarding frontline healthcare workers, and conserving finite resources. In this context, we would also like to emphasise the potential benefit of outpatient surgery for controlling nosocomial infections as it has been suggested that longer pre-operative admissions for surgical fixation of ankle fractures may increase rates, thereby increasing downstream resource utilisation and hospital staffing demands [5, 27] . cache = ./cache/cord-294294-66udu5y4.txt txt = ./txt/cord-294294-66udu5y4.txt === reduce.pl bib === id = cord-294527-fct2y5vn author = Guadarrama-Ortiz, Parménides title = Neurological Aspects of SARS-CoV-2 Infection: Mechanisms and Manifestations date = 2020-09-04 pages = extension = .txt mime = text/plain words = 8820 sentences = 441 flesch = 37 summary = The human infection of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health emergency of international concern that has caused more than 16.8 million new cases and 662,000 deaths as of July 30, 2020. Although coronavirus disease 2019 (COVID-19), which is associated with this virus, mainly affects the lungs, recent evidence from clinical and pathological studies indicates that this pathogen has a broad infective ability to spread to extrapulmonary tissues, causing multiorgan failure in severely ill patients. In this context, SARS-CoV-2 can also cause viral meningitis and encephalitis, as demonstrated by a recent report of a 64-yearold patient with laboratory-confirmed COVID-19 who presented neurologic manifestations during the infection, including lethargy, clonus, and pyramidal signs in the lower limbs as well as stiff neck and Brudzinski sign (76) . Future studies are required to evaluate the serologic features of anti-glycolipid antibodies in patients with COVID-19 to elucidate possible mechanisms underlying the association between SARS-CoV-2 infection and Guillain-Barré syndrome. cache = ./cache/cord-294527-fct2y5vn.txt txt = ./txt/cord-294527-fct2y5vn.txt === reduce.pl bib === id = cord-294079-px9c20il author = Chua, Horng-Ruey title = Ensuring Sustainability of Continuous Kidney Replacement Therapy in the Face of Extraordinary Demand: Lessons From the COVID-19 Pandemic date = 2020-06-04 pages = extension = .txt mime = text/plain words = 3928 sentences = 200 flesch = 38 summary = Consumption of CKRT resources can be made more efficient by optimizing circuit anticoagulation to preserve filters, extending use of each vascular access, lowering blood flows to reduce citrate consumption, moderating the CKRT intensity to conserve fluids, or running accelerated KRT at higher clearance to treat more patients per machine. Specifically, we aimed to: (i) develop projections regarding the demand for CKRT that are revised weekly in accordance with prevailing rates; (ii) improve efficiency of existing care practices to avoid future rationing; (iii) optimize stocks of consumables by trimming current consumption and diversifying sources, while preventing hoarding; (iv) ramp up clinical and nursing training but maintain realistic workforce awareness; and most importantly, (v) collaborate widely at a national and regional level, and stay in close communication despite the social disconnect forced by COVID-19 (Fig.1) . cache = ./cache/cord-294079-px9c20il.txt txt = ./txt/cord-294079-px9c20il.txt === reduce.pl bib === id = cord-293740-4c3yemi3 author = Ferrando, Carlos title = Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS date = 2020-07-29 pages = extension = .txt mime = text/plain words = 4327 sentences = 253 flesch = 51 summary = METHODS: This is a multicenter, prospective, observational study in consecutive, mechanically ventilated patients with ARDS (as defined by the Berlin criteria) affected with with COVID-19 (confirmed SARS-CoV-2 infection in nasal or pharyngeal swab specimens), admitted to a network of 36 Spanish and Andorran intensive care units (ICUs) between March 12 and June 1, 2020. [temperature, mean arterial pressure (MAP), heart rate], laboratory parameters (blood test, coagulation, biochemical), ventilatory parameters [tidal volume (VT), inspiratory oxygen fraction (FiO 2 ), respiratory rate (RR), PEEP, plateau pressure (Pplat), driving pressure (DP), respiratory system compliance (Crs)], the use of adjunctive therapies [recruitment maneuvers (RM), prone position, neuromuscular blocking agents (NMBA), extracorporeal membrane oxygenation (ECMO)], pharmacological treatments, disease chronology [time from onset of symptoms and from hospital admission to initiation of mechanical ventilation (MV), ventilator-free days (VFDs) during the first 30 days, ICU length of stay (LOS)]. cache = ./cache/cord-293740-4c3yemi3.txt txt = ./txt/cord-293740-4c3yemi3.txt === reduce.pl bib === id = cord-294628-ecg13s7a author = Chia, Ming Li title = Managing COVID-19 in a Novel, Rapidly Deployable Community Isolation Quarantine Facility date = 2020-09-17 pages = extension = .txt mime = text/plain words = 3676 sentences = 206 flesch = 52 summary = During the coronavirus disease 2019 (COVID-19) pandemic, Singapore implemented large-scale institutional isolation units called Community Care Facilities (CCFs) to combat the outbreak in the community by housing low-risk COVID-19 patients from April to August 2020. During the coronavirus disease 2019 (COVID-19) pandemic, Singapore implemented large-scale institutional isolation units called Community Care Facilities (CCFs) to combat the outbreak in the community by housing low-risk COVID-19 patients from April to August 2020. In the first month, a total of 3758 patients were admitted to 4 halls, 4929 in-house medical consults occurred, 136 patients were transferred to a hospital, 1 patient died 2 weeks after discharge, and no health care workers became infected. As such, isolation centers called Community Care Facilities (CCFs) were set up throughout the country to house patients with COVID-19 who were at low risk for dying of the disease. cache = ./cache/cord-294628-ecg13s7a.txt txt = ./txt/cord-294628-ecg13s7a.txt === reduce.pl bib === id = cord-294371-xot2oj2t author = Citgez, Bulent title = Management of Breast Cancer during the COVID-19 Pandemic date = 2020-06-10 pages = extension = .txt mime = text/plain words = 2222 sentences = 130 flesch = 49 summary = In this review, we tried to explain how to prevent the negative effects of the COVID-19 pandemic on the diagnosis and treatment of breast cancer patients. In this process, as in many other types of cancer, there are also challenges in the management of breast cancer treatment due to the limited use of resources and the working discipline of the healthcare staff according to the pandemic conditions. High-priority: Recommendations are applied to patients whose condition is either clinically unstable or who have life-threatening cancer burden and requires immediate hospital treatment. [7] Diagnostic imaging for an abnormal mammogram or for suspicious symptoms of breast cancer, biopsies for BI-RADS 4 or 5 lesions, and breast MRI for the extent of disease evaluation or pre-chemotherapy assessment are still being performed in hospitals having sufficient resources because pandemic may be long-lasting and this may threaten patients' lives in the long run. ER+ early breast cancer patients should have neoadjuvant endocrine therapy before surgery during the COVID-19 pandemic. cache = ./cache/cord-294371-xot2oj2t.txt txt = ./txt/cord-294371-xot2oj2t.txt === reduce.pl bib === id = cord-294907-i836d6im author = Alabdali, Abdullah title = The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak at King Abdul-Aziz Medical City-Riyadh from Emergency Medical Services Perspective date = 2020-05-20 pages = extension = .txt mime = text/plain words = 3294 sentences = 159 flesch = 48 summary = Early in 2013, KAMC-R launched the Infection Disease Epidemic Plan (IDEP), in response to the MERS-CoV outbreak, which consists of three phases that activate based on the number of confirmed cases reported to/within the hospital. 7 Following thatthe hospital medical director initiated major actions such as isolation rooms for suspected or confirmed case, implementing a screening process for all health care workers and new patients, education and training on identifying symptoms of the disease, and means of protection. Therefore, the first steps were prevention; this included early identification of any symptoms that might encounter patients or health care workers, screening the EMS providers at the beginning of each shift and after each transport through temperature checks, followed by tacking employees sick leave records. In this experience, it was clear that paramedics needed training, and once provided, they were confident and competent in transporting critically ill positive MERS-CoV patients. cache = ./cache/cord-294907-i836d6im.txt txt = ./txt/cord-294907-i836d6im.txt === reduce.pl bib === id = cord-294933-oc2glu4a author = Cinesi Gómez, César title = Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection date = 2020-06-19 pages = extension = .txt mime = text/plain words = 5643 sentences = 337 flesch = 45 summary = The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. The present document has been developed by consensus among the scientific societies involved in acute respiratory failure in adult patients, and seeks to provide a more detailed description of the recommendations on the use of non-invasive respiratory support (NIRS) in the management of acute respiratory failure (ARF) secondary to infection by the newly emergent SARS-CoV-2 coronavirus, which causes so-called COVID-19 disease, as a complement to the information emitted by the Spanish Ministry of Health, Consumer Affairs and Social Wellbeing (Ministerio de Sanidad, Consumo y Bienestar Social [MSC]), 1,2 which is frequently updated and establishes a series of general recommendations. cache = ./cache/cord-294933-oc2glu4a.txt txt = ./txt/cord-294933-oc2glu4a.txt === reduce.pl bib === id = cord-294064-vdpak3fm author = Iqbal, Muhammad Rafaih title = Single centre concept of ‘cold site’ elective surgery during the peak of COVID-19 pandemic: A cohort study date = 2020-10-06 pages = extension = .txt mime = text/plain words = 3028 sentences = 190 flesch = 59 summary = title: Single centre concept of 'cold site' elective surgery during the peak of COVID-19 pandemic: A cohort study Our hospital utilised local private hospital as a dedicated cold site (CS) for urgent elective surgery during the peak of the COVID-19 pandemic. CONCLUSION: Urgent elective surgery is safe and feasible during the COVID-19 pandemic if a dedicated cold site is available. A mortality of 19% has been reported in a recent study on 278 patients undergoing elective surgery who were diagnosed with COVID-19 peri-operatively (6) . This was a retrospective review of a prospectively maintained database of consecutive patients undergoing urgent elective surgery at the dedicated CS during the COVID-19 pandemic. J o u r n a l P r e -p r o o f J o u r n a l P r e -p r o o f ¨ This study reports findings of a dedicated cold site elective surgery during the peak of COVID-19 pandemic. cache = ./cache/cord-294064-vdpak3fm.txt txt = ./txt/cord-294064-vdpak3fm.txt === reduce.pl bib === id = cord-294959-xy8976jz author = Hsu, Elisabeth title = Allium fistulosum congee as a home remedy to ward off the corona virus at an early stage date = 2020-06-30 pages = extension = .txt mime = text/plain words = 976 sentences = 64 flesch = 67 summary = title: Allium fistulosum congee as a home remedy to ward off the corona virus at an early stage Elisabeth Hsu a,* , Buxian Zhu b , Zewan Ding b , a Institute of Social and Cultural Anthropology, School of Anthropology and Museum Ethnography, University of Oxford, Oxford, UK b Chinese Medicine, Oxford, UK At the early stage of COVID-19, patients experience flu-like symptoms such as fever, chills, headaches, sore throat and etc. 3 Based on prior experience, several COVID-19 patients were successfully treated with Allium fistulosum congee. Two to three hours after the first taking of Allium fistulosum congee, the patient started to sweat with lots of phlegm coming out and the body temperature dropped from 38.5°C to 37.3°C. Other patients who were in the early or mild stage recovered much sooner, usually within three to four days taking Allium fistulosum congee. cache = ./cache/cord-294959-xy8976jz.txt txt = ./txt/cord-294959-xy8976jz.txt === reduce.pl bib === id = cord-294969-57xgqf2g author = Green, Bart N. title = Rapid Deployment of Chiropractic Telehealth at 2 Worksite Health Centers in Response to the COVID-19 Pandemic: Observations from the Field date = 2020-06-11 pages = extension = .txt mime = text/plain words = 5987 sentences = 370 flesch = 53 summary = Therefore, the purpose of this paper is to describe the rapid deployment of remote musculoskeletal care through telehealth, particularly using real time video conferencing, for chiropractic services integrated in 2 health centers located on 2 campuses of a large company in California. There were 3 distinct challenges to operationalizing remote RTVCs: (1) the chiropractors had to conduct their part of the visits from their homes; (2) the patients had to access visits from home; and (3) there was no direct contact with the interprofessional provider team, health center management, or technical support. The setting and context of the WSHC environment is a key part of how we have operationalized the use of chiropractic RTVCs. The interprofessional collaborative team that staffs the health center greatly facilitates the ability to transition rapidly from in-clinic care to RTVCs. The providers have a regular practice of working as a team. cache = ./cache/cord-294969-57xgqf2g.txt txt = ./txt/cord-294969-57xgqf2g.txt === reduce.pl bib === id = cord-295514-vhymj0rw author = Lim, Peter A title = Impact of a viral respiratory epidemic on the practice of medicine and rehabilitation: Severe acute respiratory syndrome date = 2004-08-01 pages = extension = .txt mime = text/plain words = 5277 sentences = 244 flesch = 43 summary = Severe acute respiratory syndrome (SARS) is a new respiratory viral epidemic that originated in China but has affected many parts of the world, with devastating impact on economies and the practice of medicine and rehabilitation. Rehabilitation was significantly affected by SARS, because strict infection control measures run counter to principles such as multidisciplinary interactions, patients encouraging and learning from each other, and close physical contact during therapy. Rehabilitation medicine was increasingly affected by everstricter infection control measures regarding close contacts and interactions between health care workers. Rehabilitation medicine was directly affected when the entire neurology ward, including patients and health care staff, were transferred out to TTSH for isolation and observation because of suspicious clusters of fevers that involved both patients and staff. Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts cache = ./cache/cord-295514-vhymj0rw.txt txt = ./txt/cord-295514-vhymj0rw.txt === reduce.pl bib === id = cord-294768-bs6thjw2 author = Alonso-Fernández, Alberto title = Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study date = 2020-08-25 pages = extension = .txt mime = text/plain words = 4652 sentences = 278 flesch = 49 summary = title: Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study CONCLUSIONS: Patients with COVID-19 pneumonia and D-dimer values higher than 1 μg/mL presented a high prevalence of PE, regardless of clinical suspicion. [12] found, in a retrospective study in 184 intensive care unit (ICU) patients with severe COVID-19 pneumonia, a high prevalence of thrombotic complications and, by far, pulmonary embolism (PE) was the most frequent. Pulmonary embolism in COVID-19 pneumonia with high D-dimer values: A prospective study procoagulant (D-dimer) markers that correlated with the extend of the thromboembolic episode compared to those patients without PE. We included patients with D-dimer values higher than 1 μg/mL, which have been associated with disease severity and in-hospital mortality in patients with COVID-19 infection. Pulmonary embolism in COVID-19 pneumonia with high D-dimer values: A prospective study of our patients, allocated in the non-PE group, was not on enoxaparin prophylaxis during hospitalization. cache = ./cache/cord-294768-bs6thjw2.txt txt = ./txt/cord-294768-bs6thjw2.txt === reduce.pl bib === id = cord-295216-eff02z0i author = Ahluwalia, Ranbir title = The impact of imposed delay in elective pediatric neurosurgery: an informed hierarchy of need in the time of mass casualty crisis date = 2020-05-20 pages = extension = .txt mime = text/plain words = 5228 sentences = 327 flesch = 46 summary = While some recommendations apply to neurosurgery, particularly endoscopic sinonasal and skull base recommendations [2] , no manuscripts exist to systematically stratify risk associated with delay in common pediatric neurosurgical procedures. Urgent cases that present an immediate threat to the patient's life or neurologic well-being (e.g., shunt malfunction, acute hematoma evacuation, tumor with hydrocephalus, empyema, spinal cord compression) are straightforward and undergo prompt surgical intervention. [27] of the membership of the American Society of Pediatric Neurosurgery (ASPN) demonstrated a strong preference for using presence of a syrinx regardless of symptoms in the setting of Chiari I malformation as a threshold for surgery [27] . In a cohort of 35 patients with total obstetric brachial palsy injury, younger age at the time of surgery correlated with better functional recovery (r = − 0.356, p = 0.049), particularly with finger and thumb flexion [59] . Patients with Chiari malformation type I presenting with acute neurological deficits: case series cache = ./cache/cord-295216-eff02z0i.txt txt = ./txt/cord-295216-eff02z0i.txt === reduce.pl bib === id = cord-294557-4h0sybiy author = Stogiannos, N. title = Coronavirus disease 2019 (COVID-19) in the radiology department: What radiographers need to know date = 2020-06-04 pages = extension = .txt mime = text/plain words = 6725 sentences = 377 flesch = 50 summary = Objectives include to: i) outline pathophysiology and basic epidemiology useful for radiographers, ii) discuss the role of medical imaging in the diagnosis of Covid-19, iii) summarise national and international guidelines of imaging Covid-19, iv) present main clinical and imaging findings and v) summarise current safety recommendations for medical imaging practice. CXR imaging of suspected or confirmed Covid-19 cases should be performed with portable equipment within specifically designated isolated rooms for eliminating the risks of cross-infection within the Radiology department. After the outbreak of the Covid-19 pandemic, many professional bodies and learned societies have been quick to issue official guidelines on how medical imaging should optimally be performed for early diagnosis and related management of these patients, but also how staff should be protected from cross-infection. Chest radiographic and CT findings of the 2019 novel Coronavirus disease (COVID-19): analysis of nine patients treated in Korea Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis cache = ./cache/cord-294557-4h0sybiy.txt txt = ./txt/cord-294557-4h0sybiy.txt === reduce.pl bib === id = cord-295086-tc3re52f author = Lu, Guoguang title = Dynamic changes in routine blood parameters of a severe COVID-19 case date = 2020-05-13 pages = extension = .txt mime = text/plain words = 1749 sentences = 82 flesch = 49 summary = METHODS: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. RESULTS: Our study found that the patient's condition worsened in the first week after admission; white blood cells (WBCs), neutrophils, lymphocytes, monocytes, eosinophils, erythrocytes, hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. The number of WBCs, neutrophils, monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. In addition, it should be noted that monocytes and eosinophils were extremely low within 10 days after admission, which might indicate that the patient's condition was serious, and then gradually recovered to normal. cache = ./cache/cord-295086-tc3re52f.txt txt = ./txt/cord-295086-tc3re52f.txt === reduce.pl bib === id = cord-295332-wlnss6bg author = AL Shareef, Khaled title = Cytokine Blood Filtration Responses in COVID-19 date = 2020-05-28 pages = extension = .txt mime = text/plain words = 2679 sentences = 155 flesch = 50 summary = This work reviews effective methods of using filtration devices in treatment to reduce the level of various inflammatory mediators and discharge patients from the ICU faster. Another study involved 38 patients with septic shock associated with AKI who were treated with CVVHD with HCO membrane for 72 h. A crossover randomized double-blinded study was conducted to investigate the effect of the oXiris membrane on 16 septic shock patients with AKI. This membrane with continuous hemodiafiltration (CHDF) was used to treat 34 septic shock patients in addition to the conventional treatment according to the Surviving Sepsis Campaign guidelines. Severe acute pancreatitis patients (the study group) were treated with a combination of CPFA and CVVH, while the control group received CVVH. The authors recommend using blood filtration devices in addition to current treatment to reduce the number of patients admitted to ICUs. Correction to: clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. cache = ./cache/cord-295332-wlnss6bg.txt txt = ./txt/cord-295332-wlnss6bg.txt === reduce.pl bib === id = cord-294700-pb5k21da author = Dulek, Daniel E title = Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute COVID-19 in Pediatric Patients date = 2020-08-18 pages = extension = .txt mime = text/plain words = 14522 sentences = 835 flesch = 38 summary = Although the majority of SARS-CoV-2 infections in pediatric populations result in minimal or mild COVID-19 in the acute phase of infection, a small subset of children develop severe and even critical disease in this phase with concomitant inflammation that may benefit from immunomodulation. The framework presented herein offers an approach to decision-making regarding immunomodulatory therapy for severe or critical pediatric COVID-19 and is informed by currently available data, while awaiting results of placebo-controlled randomized clinical trials. Given the lack of available results from randomized-controlled trials of immunomodulatory therapy in children with COVID-19, the risk-benefit ratio for most pediatric patients points toward supportive care as the key management strategy. In the absence of such opportunity, and recognizing that definitive evidence is lacking, consideration for use of immunomodulatory agents in cases of SARS-CoV-2 infection with clinical and biochemical evidence of cytokine storm physiology (e.g., features of secondary HLH) should be limited to patients with clear evidence of critical COVID-19 disease and risk for multi-organ failure. cache = ./cache/cord-294700-pb5k21da.txt txt = ./txt/cord-294700-pb5k21da.txt === reduce.pl bib === id = cord-295323-snrt9odv author = Yadav, Sandeep Kumar title = Creating Backup Management Resources for Spine Care during the Coronavirus Disease 2019 Pandemic date = 2020-05-14 pages = extension = .txt mime = text/plain words = 1137 sentences = 60 flesch = 46 summary = Although the prevention and treatment of COVID 19 has become the priority for the majority of the population, most medical professionals are facing the challenge of balancing the management of this pandemic and treating patients with other diseases. Although the prevention and treatment of COVID 19 has become the priority for the majority of population, most medical professionals are facing the dilemma of balancing out essential healthcare for patients suffering from other diseases. Medical care personnel from all specialties are facing this situation and have established guidelines and recommendations that have contributed to the literature and are providing guidance for managing the pandemic. Thus, minimizing unnecessary patient visits, issuing preventive instructions to predisposed patients, ensuring the safety of the operative team, are maximizing the use of digital media for postoperative care surveillance are vital in the ongoing scenario. cache = ./cache/cord-295323-snrt9odv.txt txt = ./txt/cord-295323-snrt9odv.txt === reduce.pl bib === id = cord-294593-mh1uh1b3 author = Boloori, Alireza title = Misalignment of Stakeholder Incentives in the Opioid Crisis date = 2020-10-16 pages = extension = .txt mime = text/plain words = 6457 sentences = 305 flesch = 41 summary = Some of these issues include the inefficacy of conventional payment mechanisms in providing incentives for providers, practice guidelines in pain management that are not easily implementable across different medical specialties, barriers in adopting multi-modal pain management strategies, low capacity of providers/treatments to address opioid/substance use disorders, the complexity of addressing the co-occurrence of chronic pain and opioid use disorders, and patients' non-adherence to opioid substitution treatments. These include the implementation of prescription drug monitoring programs [54, 55] , statewide Medicaid program initiatives such as coordinated care organizations [56] [57] [58] , educational outreach and academic detailing for providers [59] [60] [61] , advances in medicine/surgery that lower post-surgical dependence on narcotics [62, 63] , the fentanyl patch-for-patch program [64] , pharmacy consult intervention [65] , quality measure development and/or quality improvement [66] , using data analytics to predict the risk of overdose [67] , and schedule change of opioid analgesics [68] . cache = ./cache/cord-294593-mh1uh1b3.txt txt = ./txt/cord-294593-mh1uh1b3.txt === reduce.pl bib === id = cord-294810-mq9vjnro author = Huang, Qiong title = Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China date = 2020-05-14 pages = extension = .txt mime = text/plain words = 3439 sentences = 195 flesch = 52 summary = title: Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China Background Clinical characteristics of patients with the coronavirus disease 2019 (COVID-19) may present differently within and outside the epicenter of Wuhan, China. According to the clinical manifestations, the confirmed COVID-19 patients can be divided into mild, common, severe, and critical type groups based on the China National Health Commission Diagnosis and Treatment Plan of Novel Coronavirus Pneumonia (trial version 6) [7] . The blood test also showed that in general, patients with severe COVID-19 had worse results such as electrolyte and inflammatory biomarker abnormalities than those in patients with the common-type infection. In this study, we reported the clinical characteristics of patients with COVID-19 as well as therapies they received during hospitalization in Hunan province, China. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series cache = ./cache/cord-294810-mq9vjnro.txt txt = ./txt/cord-294810-mq9vjnro.txt === reduce.pl bib === id = cord-295414-v10454ns author = Baktash, Vadir title = Vitamin D status and outcomes for hospitalised older patients with COVID-19 date = 2020-08-26 pages = extension = .txt mime = text/plain words = 3757 sentences = 234 flesch = 46 summary = 1 Furthermore, research by Alipio and colleagues 2 , in a retrospective study, provides evidence of an association between vitamin D deficiency and adverse outcome in patients with COVID-19. Among patients with vitamin D deficiency in the COVID-19-positive group, there was a higher average peak in D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and a higher incidence of NIV support and HDU admission (30.77% vs 9.68%) (p=0.042). The main findings of our study suggest that older patients with lower serum concentrations of 25(OH)D, when compared with aged-matched vitamin D-replete patients, may demonstrate worse outcomes from COVID-19. In non-communicable diseases, both viral and bacterial, vitamin D deficiency has been associated with increased morbidity and mortality as well as a higher incidence of acute respiratory distress syndrome in critically unwell patients. • Older patients with COVID-19 infection and vitamin D deficiency (≤30 nmol/L) have higher peak D-dimer level and higher incidence of NIV support and HDU admission. cache = ./cache/cord-295414-v10454ns.txt txt = ./txt/cord-295414-v10454ns.txt === reduce.pl bib === id = cord-295371-ccqne6nu author = Stoj, Victoria J. title = Dermatology residents and the care of patients with coronavirus disease 2019 (COVID-19) date = 2020-04-04 pages = extension = .txt mime = text/plain words = 610 sentences = 49 flesch = 63 summary = title: Dermatology residents and the care of patients with coronavirus disease 2019 (COVID-19) Additionally, there is an American Academy of Dermatology Code of Medical Ethics that states, ''It is .unethical for a dermatologist .to refuse the management of a patient because of medical risk, real or imagined (page 18, section 1C).'' 4 Subsequently, in the current pandemic, it is a dermatologist's duty to treat patients in the clinic, in the hospital, in the emergency room, and in the intensive care unit if called upon. The current COVID-19 pandemic is a public health crisis that requires physicians, of all specialties, to step up and help. The bottom line is that to fulfill your obligation as a professional in the house of medicine, ensure medical care is delivered to those in need (distributive justice), help patients, and do no harm (beneficence and nonmaleficence,) and for your own dignity, do not call a lawyer! cache = ./cache/cord-295371-ccqne6nu.txt txt = ./txt/cord-295371-ccqne6nu.txt === reduce.pl bib === id = cord-295144-tyyc81uc author = Stradner, Martin H. title = Rheumatic Musculoskeletal Diseases and COVID-19 A Review of the First 6 Months of the Pandemic date = 2020-10-09 pages = extension = .txt mime = text/plain words = 9901 sentences = 442 flesch = 39 summary = In this review, we summarize the published cases of COVID-19 infections in RMD patients, including patients with inflammatory arthritis and connective tissue diseases as well as anti-phospholipid syndrome and Kawasaki syndrome. It also reviews the general risk of viral infections in patients with RMD, the impact of disease modifying anti-rheumatic drugs (DMARDs) on the outcome of infections, and gives a comparison between present and previous coronavirus pandemics. This argues against a protective role of HCQ (in the usually administered dose for RMD patients) in SARS-CoV-2 infection, which is also supported by pharmacological in vitro data describing a much higher level needed for effective viral inhibition (61) . In conclusion, data published in the first 6 months do not consistently describe a higher risk for infection with SARS-CoV-2 or a more severe course of COVID-19 in patients with either inflammatory arthritis or connective tissue diseases. cache = ./cache/cord-295144-tyyc81uc.txt txt = ./txt/cord-295144-tyyc81uc.txt === reduce.pl bib === id = cord-295700-lzaxzuwe author = Shi, Shaobo title = Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 date = 2020-05-11 pages = extension = .txt mime = text/plain words = 3841 sentences = 192 flesch = 42 summary = CONCLUSION: The risk of in-hospital death among patients with severe COVID-19 can be predicted by markers of myocardial injury, and was significantly associated with senior age, inflammatory response, and cardiovascular comorbidities. The major findings of the present study are as follows: (i) myocardial injury is not uncommon among patients with severe COVID-19, especially among those who die; (ii) elevated levels of myocardial markers predict risk for in-hospital death; and (iii) senior age, inflammatory response, and underlying cardiovascular-related comorbidities are associated with myocardial injury in patients with COVID-19. To further analyse related factors of myocardial injury by multivariable regression, senior age, comorbidities (e.g. hypertension, coronary heart disease, chronic renal failure, and chronic obstructive pulmonary disease), and inflammatory markers (e.g. PCT and C-reactive protein) were predictors of in-hospital myocardial injury in patients with severe COVID19 . cTnI and CK-MB levels predict risk for in-hospital death, and myocardial injury is associated with senior age, inflammatory response, and cardiovascular-related comorbidities. cache = ./cache/cord-295700-lzaxzuwe.txt txt = ./txt/cord-295700-lzaxzuwe.txt === reduce.pl bib === id = cord-296018-lgx5k2kp author = Lee, Jong-Bin title = Evaluation of prognosis related to compliance with supportive periodontal treatment in patients with chronic periodontitis: a clinical retrospective study date = 2019-04-17 pages = extension = .txt mime = text/plain words = 5374 sentences = 246 flesch = 48 summary = title: Evaluation of prognosis related to compliance with supportive periodontal treatment in patients with chronic periodontitis: a clinical retrospective study Additionally, the number of newly decayed and extracted teeth and changes in alveolar bone levels around the teeth and implants were significant prognostic factors related to PC-SPT. In addition, the majority of studies mainly focused on classifying patients based on previous dental treatments and on conducting comparisons based on clinical indices in periodontal tissues without considering the SPT period [13] [14] [15] . Using patients' clinical and radiographic records, the number of newly decayed teeth, alveolar bone level changes around the teeth and implants, the number of newly extracted teeth, https://doi.org/10.5051/jpis.2019.49.2.76 Importance of supportive periodontal treatment https://jpis.org and implant removal during SPT were examined. The effect of PC-SPT on treatment prognosis was evaluated by studying its relationship with the number of newly decayed and extracted teeth and the direction of alveolar bone change around teeth and implants. cache = ./cache/cord-296018-lgx5k2kp.txt txt = ./txt/cord-296018-lgx5k2kp.txt === reduce.pl bib === id = cord-295800-w0dup04b author = So, Loletta K-Y title = Development of a standard treatment protocol for severe acute respiratory syndrome date = 2003-05-10 pages = extension = .txt mime = text/plain words = 2401 sentences = 140 flesch = 50 summary = Add combination treatment with ribavirin and methylprednisolone when: q Extensive or bilateral chest radiographic involvement q Or persistent chest radiographic involvement and persistent high fever for 2 days q Or clinical, chest radiographic, or laboratory findings suggestive of worsening q Or oxygen saturation <95% in room air Standard corticosteroid regimen for 21 days q Methylprednisolone 1 mg/kg every 8 h (3 mg/kg daily) intravenously for 5 days q Then methylprednisolone 1 mg/kg every 12 h (2 mg/kg daily) intravenously for 5 days q Then prednisolone 0·5 mg/kg twice daily (1 mg/kg daily) orally for 5 days q Then prednisolone 0·5 mg/kg daily orally for 3 days q Then prednisolone 0·25 mg/kg daily orally for 3 days q Then off Ribavirin regimen for 10-14 days q Ribavirin 400 mg every 8 h (1200 mg daily) intravenously for at least 3 days (or until condition becomes stable) q Then ribavirin 1200 mg twice daily (2400 mg daily) orally Pulsed methylprednisolone q Give pulsed methylprednisolone if clinical condition, chest radiograph, or oxygen saturation worsens (at least two of these), and lymphopenia persists q Give as methylprednisolone 500 mg twice daily intravenously for 2 days, then back to standard corticosteroid regimen Ventilation q Consider non-invasive ventilation or mechanical ventilation if oxygen saturation <96% while on >6 L per min oxygen or if patient complains of increasing shortness of breath conditioning) was increased to 10-12 changes per h. cache = ./cache/cord-295800-w0dup04b.txt txt = ./txt/cord-295800-w0dup04b.txt === reduce.pl bib === id = cord-294788-9usyb1nn author = Baek, Woong Kee title = A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 date = 2020-05-03 pages = extension = .txt mime = text/plain words = 4459 sentences = 231 flesch = 46 summary = Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the virus strain that causes coronavirus disease 2019 (COVID-19), was first identified in Wuhan, China in December 2019. It is suspected that the acute respiratory distress syndrome (ARDS)-like picture in SARS-CoV-2-infected patients is precipitated and worsened by the excess monocytes in response to GM-CSF, which is released by rapidly activated CD4+T-cell lineage [17] . have reported that the cytokine profile and the trend of the inflammatory markers of SARS-CoV-2-infected patients present similarly to the secondary hemophagocytic lymphohistiocytosis (sHLH), whose severe clinical presentation is related to the cytokine storm [23] . There is no consensus yet on how to treat SARS-CoV-2-infected patients who present with a wide spectrum of clinical symptoms and severity. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Epub ahead of print) cache = ./cache/cord-294788-9usyb1nn.txt txt = ./txt/cord-294788-9usyb1nn.txt === reduce.pl bib === id = cord-295971-jtv1jj2z author = Cho, Sun Young title = MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study date = 2016-07-09 pages = extension = .txt mime = text/plain words = 4637 sentences = 208 flesch = 56 summary = BACKGROUND: In 2015, a large outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection occurred following a single patient exposure in an emergency room at the Samsung Medical Center, a tertiary-care hospital in Seoul, South Korea. INTERPRETATION: Our results showed increased transmission potential of MERS-CoV from a single patient in an overcrowded emergency room and provide compelling evidence that health-care facilities worldwide need to be prepared for emerging infectious diseases. Excluding three patients with confi rmed MERS-CoV infection who were not identifi ed in the initial patient contact investigation (appendix p 5), the overall attack rate for patients in the emergency room was 4% (30 of 675). No MERS-CoV infection was reported in patients and visitors who had been in the emergency room on May 29 during the time period when they were exposed only to zones II (n=81) or III (n=15), while Patient 14 was confi ned to zone IV. cache = ./cache/cord-295971-jtv1jj2z.txt txt = ./txt/cord-295971-jtv1jj2z.txt === reduce.pl bib === id = cord-296113-syi2fwuo author = Peng, Mian title = Two mechanically ventilated cases of COVID-19 successfully managed with a sequential ventilation weaning protocol: Two case reports date = 2020-08-06 pages = extension = .txt mime = text/plain words = 2618 sentences = 148 flesch = 51 summary = BACKGROUND: Patients with critical coronavirus disease 2019 (COVID-19), characterized by respiratory failure requiring mechanical ventilation (MV), are at high risk of mortality. When their condition did not improve after 2 h of NIV, each patient was advanced to MV [tidal volume (Vt), 6 mL/kg ideal body weight (IBW); 8-10 cmH(2)O of positive end-expiratory pressure; respiratory rate, 20 breaths/min; and 40%-80% FiO(2)] with prone positioning for 12 h/day for the first 5 d of MV. CONCLUSION: A MV protocol attentive to intubation/extubation timing, prone positioning early in MV, infection control, and sequential withdrawal of respiratory support, may be an effective regimen for patients with critical COVID-19. In accordance with this recommendation, we summarize our weaning procedure and associated experience with two critical COVID-19 patients, including intubation timing, use of the prone position, infection control, and sedation titration. cache = ./cache/cord-296113-syi2fwuo.txt txt = ./txt/cord-296113-syi2fwuo.txt === reduce.pl bib === id = cord-296182-hhswage4 author = Meng, Lingzhong title = Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience date = 2020-04-08 pages = extension = .txt mime = text/plain words = 6532 sentences = 364 flesch = 44 summary = Healthcare providers, who are tasked with taking care of critically ill patients, need to perform the best practices of intubation and ventilation tailored explicitly to the victims of this sweeping COVID-19 outbreak and, at the same time, adhere to strict self-protection precautions. The Chinese Society of Anesthesiology Task Force on Airway Management released a fast-track publication with the recommendation to proceed with endotracheal intubation for patients showing no improvement in respiratory distress, tachypnea (respiratory rate greater than 30 per minute), and poor oxygenation (Pao 2 to Fio 2 ratio less than 150 mmHg) after 2-h highflow oxygen therapy or noninvasive ventilation. Although the aerosol-generating potential of noninvasive ventilation is a potential concern to some providers, 19 the bilevel positive airway pressure machine is widely used amid this outbreak for patients with acute hypoxemic respiratory failure in Wuhan and the rest of China. cache = ./cache/cord-296182-hhswage4.txt txt = ./txt/cord-296182-hhswage4.txt === reduce.pl bib === id = cord-295798-x7or932x author = Ferrey, Antoney J. title = A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease date = 2020-03-28 pages = extension = .txt mime = text/plain words = 3030 sentences = 157 flesch = 46 summary = title: A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease During this interval, he reported nausea, vomiting, diarrhea, and low-grade fevers but was not suspected of COVID-19 infection until he developed respiratory symptoms and was admitted to the hospital. We present a case of COVID-19 in the United States in a long-term dialysis-dependent ESRD patient reported thus far in the 2020 COVID-19 pandemic. The following day the patient traveled by commercial airline from Southern California to Utah where he presented to an emergency department for continued intermittent vomiting and fevers but was now reporting mild congestion and cough. This case report highlights the importance of considering COVID-19 infection in a variety of clinical presentation that may not initially include typical respiratory symptom to prevent ongoing exposure of potentially affected individuals to the general population. cache = ./cache/cord-295798-x7or932x.txt txt = ./txt/cord-295798-x7or932x.txt === reduce.pl bib === id = cord-295523-5pv7kw6i author = Picchianti Diamanti, Andrea title = Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity date = 2020-05-08 pages = extension = .txt mime = text/plain words = 7905 sentences = 390 flesch = 39 summary = However, in about 20% of patients, the infection progresses to severe interstitial pneumonia and can induce an uncontrolled host-immune response, leading to a life-threatening condition called cytokine release syndrome (CRS). We critically review the rationale for the adoption of immunosuppressive agents, commonly used in autoimmune diseases, in the treatment of SARS-CoV-2 infection and report current knowledge of ongoing studies. The exacerbated reaction to infections or to biological therapy is caused by the rapid recruitment of macrophages and neutrophils, which produce pro-inflammatory cytokines and alter the fragile balance between a controlled immune response and a host-damaging reaction. As of now, four clinical trials are recruiting patients with COVID-19, severe acute respiratory failure, and CRS, aiming at evaluating the safety and effectiveness of anakinra alone or in combination with anti-IL-6 agents (NCT04330638, NCT0432402, NCT04357366, NCT04339712). High disease activity is associated with an increased risk of infection in patients with rheumatoid arthritis cache = ./cache/cord-295523-5pv7kw6i.txt txt = ./txt/cord-295523-5pv7kw6i.txt === reduce.pl bib === id = cord-295794-glcg36si author = Seghers, Victor J. title = After the initial COVID-19 surge: a phased radiology departmental re-opening plan date = 2020-08-22 pages = extension = .txt mime = text/plain words = 4747 sentences = 201 flesch = 37 summary = Social distancing, stay home/work safe orders, protective measures for vulnerable individuals (e.g., immunocompromised patients), masking protocols, visitation policies, testing and many more measures resulted in an accelerated but necessary ramping down of elective hospital services [4] [5] [6] [7] [8] [9] . While the radiologist-in-chief also participates in daily meetings with other clinical service chiefs and executive leadership for the hospital, the radiologist-in-chief is an integral member of the systemwide "Phased Recovery and Redesign Team" as well, which includes team captains for infection control, surgery, anesthesia, emergency and urgent care centers, radiology, pathology, ambulatory medicine, specialty care centers, e-health, revenue cycle and billing, and marketing and public relations. This can include patient-directed online scheduling and expanded access to imaging, offering same-day service with hours and locations adapted to the patient and family lifestyle; improved use of virtual dashboards to more easily track various metrics including MR efficiency, sedation utilization, and length of patient stay in the imaging department; and investment in Table 2 Radiology: the opportunity to re-design operations post COVID-19 cache = ./cache/cord-295794-glcg36si.txt txt = ./txt/cord-295794-glcg36si.txt === reduce.pl bib === id = cord-296588-q2716lda author = Hanson, Kimberly E title = Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19 date = 2020-06-16 pages = extension = .txt mime = text/plain words = 10179 sentences = 681 flesch = 47 summary = OBJECTIVE: The IDSA's goal was to develop an evidence-based diagnostic guideline to assists clinicians, clinical laboratorians, patients and policymakers in decisions related to the optimal use of SARS-CoV-2 nucleic acid amplification tests. It is important to note as well, that not all specimens were collected from the same patient at the same time, the time of collection from symptom onset was not provided in all studies and various approaches for establishing SARS-CoV-2 positivity were used to define positive results (i.e., clinical evaluation, detection different gene targets versus nucleic acid sequencing). While NP swab collection is widely used and the primary specimen type for commercial direct SARS-CoV-2 test platforms, based on current available evidence, clinical practice, and availability of testing resources, the panel believes there are comparable alternative methods for sampling the nasal passages. cache = ./cache/cord-296588-q2716lda.txt txt = ./txt/cord-296588-q2716lda.txt === reduce.pl bib === id = cord-296494-6kn4mr04 author = Saban-Ruiz, J. title = COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs. The Role of Aging Beyond Topics date = 2020-05-12 pages = extension = .txt mime = text/plain words = 6444 sentences = 326 flesch = 50 summary = Bearing this in mind, it is quite likely, that if we have fewer complications, particularly severe ones (cardiac arrest, ventricular tachyarrhythmia, acute heart failure, acute coronary syndrome, haemorrhagic or massive ischaemic stroke), this integrated approach could cut down the elevated mortality in the highest risk group (cancer, COPD and oldest subjects with comorbidities), usually preceded by a multi-organ failure. In aged COVID-19 patients or with history of coronary artery disease (CAD) an acute coronary syndrome (ACS) can also be seen for plaque vulnerability in the presence of a pro-inflammatory state with cytokine release (71) but from the experience in animals, could it be plausible that any of them could be due to arteritis? The third aspect would be the combination of T2DM and Heart failure (HF) (the most frequent cardiac complication in any of the phases of the disease), which is present in a high percentage of patients, especially those at higher risk. cache = ./cache/cord-296494-6kn4mr04.txt txt = ./txt/cord-296494-6kn4mr04.txt === reduce.pl bib === id = cord-296562-3h2oqb9k author = Guillén, Lucía title = Preemptive interleukin-6 blockade in patients with COVID-19 date = 2020-10-08 pages = extension = .txt mime = text/plain words = 4874 sentences = 246 flesch = 44 summary = In contrast to other respiratory viral infections like influenza, a major pathogenic mechanism implicated in severe clinical manifestations of COVID-19 is an aberrant host immune response resulting in an excessive cytokine and chemokine release known as "cytokine storm" or "cytokine release syndrome" 2,3 . In a sensitivity analysis including only the 55 patients with confirmed SARS-CoV-2 infection by RT-PCR, the significant variables in the adjusted multivariate model were a NLR > 2.55 (OR 5.26; 95% CI 1.02-25), higher Charlson comorbidity index (OR 1.56; 95% CI 1.04-2.34) per unit, and higher SOFA score (OR 5.05; 95% CI 1.10-23.24) (Supplementary Table 2 ). This biomarker reflects excessive inflammation and dysregulation of immune cells that play a central role in severity of disease in viral infections 23 , and has been associated with mortality in patients hospitalized with COVID-19 24 . www.nature.com/scientificreports/ four comorbidities are included in the Charlson index, and have been associated with higher disease severity in patients with COVID-19 31 . cache = ./cache/cord-296562-3h2oqb9k.txt txt = ./txt/cord-296562-3h2oqb9k.txt === reduce.pl bib === id = cord-296013-6ej3pd0u author = Trinidad, John title = Telemedicine for Inpatient Dermatology Consultations in Response to the COVID-19 Pandemic date = 2020-04-24 pages = extension = .txt mime = text/plain words = 328 sentences = 25 flesch = 40 summary = key: cord-296013-6ej3pd0u title: Telemedicine for Inpatient Dermatology Consultations in Response to the COVID-19 Pandemic cord_uid: 6ej3pd0u 3 Inpatient 46 dermatology services will continue to provide impactful care throughout the COVID-19 crisis 47 with a particular need to help allocate scarce resources. Outpatient 55 teledermatology services have the potential to increase access to dermatology care, and to 56 address health care disparities for urban-underserved and rural populations. 5 Dermatologists are poised to 58 utilize teledermatology to increase access to dermatologic care for hospitalized patients, reduce 59 the risk of infection of patients, trainees and staff, and reduce the use of precious resources such 60 as personal protective equipment (PPE) and medical supplies. Characterisation and diagnosis of ulcers in 108 inpatient dermatology consultation services: A multi-centre study Improved patient access and outcomes with the 111 integration of an eConsult program (teledermatology) within a large academic medical 112 center cache = ./cache/cord-296013-6ej3pd0u.txt txt = ./txt/cord-296013-6ej3pd0u.txt === reduce.pl bib === id = cord-296605-p67twx7a author = LAU, Arthur Chun-Wing title = Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) date = 2004-03-10 pages = extension = .txt mime = text/plain words = 4846 sentences = 247 flesch = 38 summary = title: Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) Most SARS patients would require high flow oxygen supplementation, 20–30% required intensive care unit (ICU) or high dependency care, and 13–26% developed acute respiratory distress syndrome (ARDS). The management of critically ill SARS patients requires timely institution of pharmacotherapy where applicable and supportive treatment (oxygen therapy, noninvasive and invasive ventilation). More than onethird of all the SARS patients required high flow oxygen therapy [4] , 20-30% required intensive care unit (ICU) admission or high dependency care, and 13-26% developed acute respiratory distress syndrome (ARDS) [5, 6] . Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China Evaluation of non-invasive positive pressure ventilation in treatment for patients with severe acute respiratory syndrome Clinical observation of non-invasive positive pressure ventilation (NIPPV) in the treatment of severe acute respiratory syndrome (SARS) cache = ./cache/cord-296605-p67twx7a.txt txt = ./txt/cord-296605-p67twx7a.txt === reduce.pl bib === id = cord-296219-zzg9hds0 author = Battaglini, Denise title = Neurological Manifestations of Severe SARS-CoV-2 Infection: Potential Mechanisms and Implications of Individualized Mechanical Ventilation Settings date = 2020-08-12 pages = extension = .txt mime = text/plain words = 7486 sentences = 369 flesch = 33 summary = Within this Abbreviations: ACE2, angiotensin-converting enzyme-2; ANE, acute necrotizing encephalopathy; ARDS, acute respiratory distress syndrome; BALF, bronchoalveolar lavage fluid; BBB, blood brain-barrier; CA, Ammon's horn; CD, cluster of differentiation; CI, confidence interval; CNS, central nervous system; CoV, coronavirus; COVID-19, coronavirus disease 2019; CT, computed tomography; CXCR, chemokine receptor; DIC, disseminated intravascular coagulation; DO 2 , oxygen delivery; DPP4, dipeptidyl dipeptidase-4; ECMO, extracorporeal membrane oxygenation; FiO 2 fraction of inspired oxygen; FOX, forkhead box; HLH, hemophagocytic lymphohistiocytosis; ICAM, intracellular adhesion molecule; ICH, intracerebral hemorrhage; ICP, intracranial pressure; IFN, interferon; MERS, Middle East respiratory syndrome; MHV, mouse hepatitis virus; MRI, magnetic resonance images; nCoV, novel coronavirus; OR, odds ratio; PaCO 2 , partial pressure of carbon dioxide; PaO 2 partial pressure of oxygen; PbtO 2 brain tissue oxygenation tension; PCR, polymerase chain reaction; PEEP, positive end-expiratory pressure; PRES posterior reversible encephalopathy syndrome; RM, recruitment maneuvers; RNA, ribonucleic acid; SARS, severe acute respiratory syndrome; TLRs, toll-like receptor; TMPRSS2 transmembrane serine protease 2; TNF, tumor necrosis factor; WHO, World Health Organization. cache = ./cache/cord-296219-zzg9hds0.txt txt = ./txt/cord-296219-zzg9hds0.txt === reduce.pl bib === id = cord-295703-no45mgyd author = ALTAY, O. title = Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date = 2020-10-05 pages = extension = .txt mime = text/plain words = 3977 sentences = 231 flesch = 50 summary = Combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate is being studied for the treatment of patients with COVID-19. CONCLUSIONS In patients with mild-to-moderate COVID-19, CMCS resulted in a significant reduction in recovery time and liver enzymes associated with hepatic function compared to placebo. Recently, we performed integrative analysis of multi-omics data on different metabolic conditions and found that combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and Lcarnitine tartrate may be used for treatment of the patients with non-alcoholic fatty liver diseases (11, 12) . In this randomized, open-label, placebo-controlled, phase 2 trial involving ambulatory COVID-19 patients, we found that the combination of CMCS and hydroxychloroquine significantly reduced the average recovery time compared with hydroxychloroquine and placebo (6.6 days vs 9.3 days, respectively). cache = ./cache/cord-295703-no45mgyd.txt txt = ./txt/cord-295703-no45mgyd.txt === reduce.pl bib === id = cord-296676-2anl2agl author = Goldberg, Michael F. title = Neuroradiologic manifestations of COVID-19: what the emergency radiologist needs to know date = 2020-08-21 pages = extension = .txt mime = text/plain words = 4158 sentences = 213 flesch = 43 summary = Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global pandemic with a wide spectrum of clinical signs and symptoms. These neurologic manifestations were more common in severely affected patients, tended to occur early in the disease course, and could be the initial, presenting clinical evidence of COVID-19 [4] . Lastly, the authors note that ECMO alone (in the absence of SARS-CoV-2 infection) is a risk factor for intracranial hemorrhage, further limiting the generalizability of this small case series. Regardless, prior studies that evaluated neuroimaging findings of patients infected with other members of the Betacoronavirus genus have also demonstrated significant abnormalities, including intracranial hemorrhage and evidence of acute disseminated encephalomyelitis (ADEM), which could represent sequelae of inflammatory response and/or direct CNS infection [50, 51] . On behalf of the CoCo Neurosciences study group (2020) Retrospective observational study of brain magnetic resonance imaging findings in patients with acute SARS-CoV-2 infection and neurological manifestations cache = ./cache/cord-296676-2anl2agl.txt txt = ./txt/cord-296676-2anl2agl.txt === reduce.pl bib === id = cord-296440-18vpg419 author = Beurnier, Antoine title = Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation date = 2020-07-30 pages = extension = .txt mime = text/plain words = 3554 sentences = 206 flesch = 49 summary = The objective of this study was to investigate the characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who required hospitalisation during the spring 2020 outbreak in Paris, France. As the world faces the coronavirus disease 2019 (COVID-19) pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, concerns have arisen about a possible increased risk of asthma exacerbations. In Wuhan, authors pointed out a rate of 0.9% [3] , markedly lower than that in the local population; in another study investigating the clinical characteristics and allergy status of 140 patients infected by SARS-CoV-2 in Wuhan, no patient were reported as being asthmatic [3] . All adult patients hospitalized from March 15, 2020 to April 15, 2020 with a diagnosis of SARS-CoV-2 infection and reporting a history of asthma were included. Moreover, obesity, hypertension and diabetes were the most common comorbidities observed in our cohort of hospitalized asthmatics with COVID-19, which is consistent with earlier research in other patient groups [4] [23] . cache = ./cache/cord-296440-18vpg419.txt txt = ./txt/cord-296440-18vpg419.txt === reduce.pl bib === id = cord-296331-i4hyzqcv author = Adapa, Sreedhar title = COVID-19 Pandemic Causing Acute Kidney Injury and Impact on Patients With Chronic Kidney Disease and Renal Transplantation date = 2020-06-04 pages = extension = .txt mime = text/plain words = 5086 sentences = 289 flesch = 49 summary = COVID-19 infection causes acute kidney injury (AKI) and is an independent risk factor for mortality. The impact of COVID-19 infection on chronic kidney disease (CKD) and renal transplant patients is also discussed in the manuscript. Acute kidney injury (AKI) was seen in 5-15% of the cases infected with SARS-CoV and MERS-CoV, and had a higher mortality rate of 60-90% as per the literature [12] . We summarized the finding from multiple studies including patient characteristics, co-morbidities, incidence of AKI in general as well as ICU/severely ill patients, number of patients requiring continuous renal replacement therapy (CRRT), extracorporeal membrane oxygenation (ECMO) and mortality in Table 2 [9-11, 13, 19, 22-24, 26-32] . Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Infection. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan cache = ./cache/cord-296331-i4hyzqcv.txt txt = ./txt/cord-296331-i4hyzqcv.txt === reduce.pl bib === id = cord-296694-2js639bk author = Price, Laura C title = Thrombosis and COVID-19 pneumonia: the clot thickens! date = 2020-06-18 pages = extension = .txt mime = text/plain words = 2396 sentences = 120 flesch = 38 summary = The true prevalence of thrombosis associated with COVID-19 infection is unknown, as most studies to date do not include systematic and comprehensive investigation protocols. Two recent Dutch studies have reported cumulative incidences of thrombotic events between 48 and 49% respectively in their ICUs in patients with COVID-19 pneumonia [10, 11] . refine this further by describing a 50% cumulative incidence of pulmonary embolism (PE), diagnosed by CT-pulmonary angiogram (PA), in COVID-19 patients admitted to ICU in two hospitals of the University of Paris (ERJ ref Bompard). In addition to ACE2 mediated SARS-CoV-2 viral entry, recent reports of affinity of the SARS-CoV-2 spike protein and CD147, a membrane glycoprotein and extracellular matrix metalloproteinase inducer expressed on a variety of haematopoietic cell lines, suggest another potentially novel mechanism of thrombosis and inflammation in the arterial and venous circulations [27] . High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients cache = ./cache/cord-296694-2js639bk.txt txt = ./txt/cord-296694-2js639bk.txt === reduce.pl bib === id = cord-297127-nhgm09db author = Hasseli, Rebecca title = National registry for patients with inflammatory rheumatic diseases (IRD) infected with SARS-CoV-2 in Germany (ReCoVery): a valuable mean to gain rapid and reliable knowledge of the clinical course of SARS-CoV-2 infections in patients with IRD date = 2020-09-02 pages = extension = .txt mime = text/plain words = 4093 sentences = 218 flesch = 45 summary = OBJECTIVES: Patients with inflammatory rheumatic diseases (IRD) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be at risk to develop a severe course of COVID-19. 2 In this situation, patients with inflammatory rheumatic diseases (IRD) may face a particular risk as their disease, especially when clinically active, and their immunomodulatory treatment may impact the course of COVID-19 infection. However, firm knowledge of the course of SARS-CoV-2 infection in patients with IRD is missing, and therefore, evidence-based recommendations for the management of COVID-19 in patients with rheumatic disorders and antirheumatic treatments are lacking. As necessary data cannot be extracted from clinical charts or health insurance records, the DGRh and the Justus-Liebig University Giessen decided to establish a web-based registry, which allows a rapid and timely collection of IRD cases with confirmed SARS-CoV-2 infections in Germany to analyse the clinical course of SARS-CoV-2 infections in patients with IRD and to develop guidance for the management of patients with IRD during the COVID-19 pandemic. cache = ./cache/cord-297127-nhgm09db.txt txt = ./txt/cord-297127-nhgm09db.txt === reduce.pl bib === id = cord-296607-h2zwlyz7 author = Watson, Ryan A. title = Anti-coagulant and anti-platelet therapy in the COVID-19 patient: a best practices quality initiative across a large health system date = 2020-06-09 pages = extension = .txt mime = text/plain words = 7738 sentences = 370 flesch = 35 summary = What is clear is that patients appear to be at higher risk for thrombotic disease states including acute coronary syndrome (ACS), venous thromboembolism (VTE) such as deep vein thrombosis (DVT) or pulmonary embolism (PE), or stroke. In most scenarios, direct oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) are recommended over warfarin due to large randomized controlled trials showing noninferiority or superiority for stroke reduction and superiority for bleeding risk in patients with non-valvular atrial fibrillation [29] [30] [31] [32] . The use of UFH or LMWH may be considered in patients with high potential stroke risk and new onset atrial fibrillation; however, heparin drips require constant monitoring and titration of dosing during hospitalization leading to increased nursing exposure to potential COVID-19 patients. A French cohort of ICU patients on pharmacologic prophylaxis found a high prevalence of thrombotic complications including PE, stroke, circuit clotting of continuous renal replacement therapy or extracorporeal membrane oxygenation (ECMO) with minimal bleeding risk suggesting the need for higher doses of prophylactic anticoagulation in this patient population [70] . cache = ./cache/cord-296607-h2zwlyz7.txt txt = ./txt/cord-296607-h2zwlyz7.txt === reduce.pl bib === id = cord-296881-2g81sjnl author = Nabil, Ahmed title = Current coronavirus (SARS-CoV-2) epidemiological, diagnostic and therapeutic approaches: An updated review until June 2020 date = 2020-07-20 pages = extension = .txt mime = text/plain words = 4802 sentences = 253 flesch = 43 summary = On May 7, 2020, Gilead Sciences, announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) has granted regulatory approval of Veklury® (Remdesivir) as a treatment for SARS-CoV-2 infection, the virus that causes COVID-19 acute respiratory syndrome, under an exceptional approval pathway. In COVID-19 infection, a massive number of T-lymphocytes and mononuclear macrophages are activated, emitting different cytokines such as interleukin-6 (IL-6), which binds to the IL-6 receptor on its target cells, causing the cytokine storm and severe inflammatory responses in most organs including lungs, liver, kidney and other tissues and organs. Moreover, in July 2020 the WHO discontinued clinical trials with hydroxychloroquine and lopinavir/ritonavir treatment arms for COVID-19 (WHO, 2020b), where both therapies produced little and no reduction in the mortality of hospitalized SARS-CoV-2 cases when compared to standard of care. COVID-19 infection and treatment with hydroxychloroquine cause severe haemolysis crisis in a patient with glucose-6-phosphate dehydrogenase deficiency cache = ./cache/cord-296881-2g81sjnl.txt txt = ./txt/cord-296881-2g81sjnl.txt === reduce.pl bib === id = cord-297208-f4ob3ox6 author = Pisano, Antonio title = Cardiothoracic surgery at the time of COVID-19 pandemic: lessons from the East (and from a previous epidemic) for western battlefields date = 2020-05-06 pages = extension = .txt mime = text/plain words = 1376 sentences = 62 flesch = 39 summary = 1 Evidently, countries which faced the severe acute respiratory syndrome (SARS) outbreak, the first coronavirus pandemic of the current century which affected more than 8000 people (mainly in China, Vietnam, Singapore and Canada) in 2003 7 , were much more prepared, both culturally and in terms of facilities and equipment, as compared with western countries (many of which had to face, in the initial stages of the emergency, the shortage of even simple and cheap devices such as surgical masks). cache = ./cache/cord-297208-f4ob3ox6.txt txt = ./txt/cord-297208-f4ob3ox6.txt === reduce.pl bib === id = cord-297132-lhfa9fl5 author = Aghagoli, Ghazal title = Neurological Involvement in COVID-19 and Potential Mechanisms: A Review date = 2020-07-13 pages = extension = .txt mime = text/plain words = 5940 sentences = 280 flesch = 36 summary = In this review, we synthesize a range of clinical observations and initial case series describing potential neurologic manifestations of COVID-19 and place these observations in the context of coronavirus neuro-pathophysiology as it may relate to SARS-CoV-2 infection. The novel 2019 coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) results in a variety of symptoms including fever, cough, and fatigue [1] . The Kawasaki-like syndrome that is now described in young patients following COVID-19 infection and associated with a hyper-inflammatory state is further suggestive of a vascular inflammatory potential of SARS-CoV-2 [48, 49] . Once established in the CNS, SARS-CoV, the virus responsible for Severe Acute Respiratory Syndrome (SARS), has been shown to be capable of inducing rapid transneuronal spread and death of infected neurons in transgenic mice models expressing human ACE2 receptors [63] . cache = ./cache/cord-297132-lhfa9fl5.txt txt = ./txt/cord-297132-lhfa9fl5.txt === reduce.pl bib === id = cord-297138-t8b3914h author = Duijker, G. title = Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection: Results from a double-blind randomized controlled trial date = 2015-04-02 pages = extension = .txt mime = text/plain words = 6832 sentences = 325 flesch = 49 summary = Conclusions Compared with placebo the essential-oil extract of three Cretan aromatic plants provided no detectable statistically significant benefit or harm in the patients with upper respiratory illness, although descriptive differences were identified in favorable direction mainly in the virus-positive population. As stated above, this study reports the results of the effectiveness of an extract based on three Cretan aromatic plants in the reduction of duration and severity of symptoms of patients with upper respiratory tract infections, utilizing a standardized questionnaire, physical examination measurements and the decrease of inflammation assayed by C-reactive protein [CRP] levels. Severity of symptoms over the study period was compared between intervention and control groups, using the 19-item WURSS-21 scores, with both univariate techniques and multiple linear regression models, adjusting for age, sex, initial CRP level, body mass index (BMI) and the presence of chronic diseases. cache = ./cache/cord-297138-t8b3914h.txt txt = ./txt/cord-297138-t8b3914h.txt === reduce.pl bib === id = cord-297093-ld89vmct author = Clark, Kristina E N title = Safety of intravenous Anakinra in COVID-19 with evidence of hyperinflammation, a case series date = 2020-08-04 pages = extension = .txt mime = text/plain words = 3236 sentences = 198 flesch = 46 summary = CONCLUSION: Intravenous anakinra is safe to use in patients with COVID-19 and evidence of supra-added bacterial infection. These patients all showed evidence of hyperinflammation with raised inflammatory markers, and CRP, and were given intravenous anakinra, with safe and successful use, suggesting the potential benefit from IL-1 blockade in this subgroup of patients with confirmed COVID-19. We present four cases of immunosuppressed patients, receiving beneficial effects from the use of intravenous anakinra to treat severe COVID-19 with hyperinflammation and concomitant bacterial infections. Our case series supports the hypothesis of IL-1 blockade as an important disease modifying treatment in those patients with severe late stage COVID-19, with evidence of cytokine storm. We believe that administering intravenous anakinra at the height of the cytokine storm has profound beneficial effects, both clinically and biochemically on patients with severe COVID-19 infection. cache = ./cache/cord-297093-ld89vmct.txt txt = ./txt/cord-297093-ld89vmct.txt === reduce.pl bib === id = cord-297327-19dfgfz6 author = Drożdżal, Sylwester title = COVID-19: Pain Management in Patients with SARS-CoV-2 Infection—Molecular Mechanisms, Challenges, and Perspectives date = 2020-07-20 pages = extension = .txt mime = text/plain words = 5672 sentences = 319 flesch = 41 summary = Many patients with SARS-CoV-2 infection will suffer from severe pain and require reliable pain assessment to provide adequate analgesia, often with multiple drugs, including opioids, nonPutative mechanisms of myalgia and headache during viral infection. Many patients with SARS-CoV-2 infection will suffer from severe pain and require reliable pain assessment to provide adequate analgesia, often with multiple drugs, including opioids, non-steroidal inflammatory drugs or analgosedation [52] . Recently, concerns about the possible higher frequency of adverse effects and exacerbation of symptoms of viral respiratory tract infections, such as COVID-19, in patients treated with NSAIDs have been raised [67] . There are reports of a significantly higher use of opioids because of sedation requirements during respiratory failure caused by SARS-CoV-2, which highlights the importance of undertaking a study aiming to determine efficacious and safe procedures of pain management in patients with COVID-19. cache = ./cache/cord-297327-19dfgfz6.txt txt = ./txt/cord-297327-19dfgfz6.txt === reduce.pl bib === id = cord-297532-ktiwfcop author = De Fata Salvatores, Gaia title = Patients with bullous disorders during COVID‐19 period: management and adherence to treatment date = 2020-05-26 pages = extension = .txt mime = text/plain words = 558 sentences = 34 flesch = 44 summary = SARS-CoV2 infection has now spread all over the world and higher mortality rates have been reported among elderly and comorbid (diabetes, cardiovascular disease, immunosuppression) patients. We want to share our experience about the management of patients with bullous disorders, in particular pemphigoid disease in our outpatient clinic during COVID-19 pandemic. 10 patients (6 women and 4 men) with a median age of 68.5 years, affected by bullous pemphigoid, all histologically confirmed, were already followed in our Day-Hospital service before the COVID-19 pandemic spread. Weekly telephonic consultations were performed in order to control patients adherence to treatment and to avoid the risk of COVID-19 infection. In literature, several articles suggesting the use of teledermatology services, such as video-call visits, e-mail and mobile applications as useful tool to take care of patients during this pandemic period have already been cache = ./cache/cord-297532-ktiwfcop.txt txt = ./txt/cord-297532-ktiwfcop.txt === reduce.pl bib === id = cord-297638-ab70s980 author = Stephens, Angela J. title = General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic date = 2020-04-28 pages = extension = .txt mime = text/plain words = 4515 sentences = 286 flesch = 42 summary = 31 Additionally, this trial also demonstrated increased maternal morbidity, such as hemorrhage and infection, associated with expectant management of PPROM after 34 weeks that would further increase exposure to different medical personnel, movement between different hospital settings (i.e., labor, operating room, and intensive care unit), and overall length of stay. Although there has been a recent trend to allow a longer second stage of labor in hope of reducing the cesarean delivery rate due to failure to progress in the second stage, a prolonged second stage may be ill advised during the COVID-19 pandemic due to an increased risk of respiratory secretion exposures to visitors and medical personnel. An Analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks' gestation: a multicentre randomized controlled trial (MICADO STUDY) cache = ./cache/cord-297638-ab70s980.txt txt = ./txt/cord-297638-ab70s980.txt === reduce.pl bib === id = cord-297832-picpuzvo author = Salazar, Rafael title = Decreased Mortality in Patients With Severe Bronchospasm Associated With SARS-CoV-2: An Alternative to Invasive Mechanical Ventilation date = 2020-10-06 pages = extension = .txt mime = text/plain words = 1768 sentences = 110 flesch = 47 summary = The number of patients with acute episodes of severe bronchospasm needing intubation and ventilatory support has increased rapidly during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) pandemic. Anteroposterior chest X-ray at the time of acute bronchospasm with Radiographic Assessment of Lung Edema (RALE) score 2 The initial management comprised placing the patient in the prone position and administering oxygen at high flow through a non-rebreather mask with flow between 10 and 15 liters per minute until reaching 100% FiO 2 . To improve ventilatory mechanics and ultimately postpone the need for IMV due to acute bronchospasm in patients diagnosed with COVID-19, we put in place a therapeutic approach consisting of early respiratory therapy and pharmacological bronchospasm rescue approach. The therapeutic bundle of early respiratory therapy, consisting of deep inspiration with inspiratory hold, and pharmacological bronchospasm rescue decreased the need for invasive mechanical ventilation in patients with bronchospasm associated with SARS-CoV-2 and reduced the mortality rate. cache = ./cache/cord-297832-picpuzvo.txt txt = ./txt/cord-297832-picpuzvo.txt === reduce.pl bib === id = cord-296773-5o4hr6ir author = Zeneli, A. title = Mitigating strategies and nursing response for cancer care management during the COVID‐19 pandemic: an Italian experience date = 2020-10-02 pages = extension = .txt mime = text/plain words = 4696 sentences = 207 flesch = 42 summary = In the early phase of the pandemic, the search of emerging literature was aimed at finding peer-reviewed information needed to keep nursing teams and other healthcare professionals upto-date in the following areas: disease physiopathology and symptoms, ways of person-to-person transmission; evidence or recommendations on infection prevention and control precaution measures; epidemiology, reusable equipment and environmental cleaning procedures, diagnostic tests, efficacy of personal protective equipment (PPE) and communication strategies in healthcare organizations during health emergency events. Patient, caregiver and employee safety, patient health outcomes, use of resources Adopted strategies and instruments for achieving goals Risk assessment to screen those with flu-like symptoms and refer them to their general practitioner for early communication, isolation and treatment for COVID-19 to prevent severe disease; telephone triage of patients before planning their visit to hospital; triaging patients and their caregivers before their access to cancer services; Continuity of essential services, appropriate case management Communication instruments cache = ./cache/cord-296773-5o4hr6ir.txt txt = ./txt/cord-296773-5o4hr6ir.txt === reduce.pl bib === id = cord-297759-arg71du6 author = Triantafyllou, Tania title = Esophageal cancer: challenges, concerns, and recommendations for management amidst the COVID-19 pandemic date = 2020-06-22 pages = extension = .txt mime = text/plain words = 3740 sentences = 157 flesch = 30 summary = The primary aim of this review is to summarize the salient evidence for recommendations and optimal treatment strategies for patients with esophageal cancer amidst the COVID-19 pandemic. In a viral pandemic, clinicians should balance the need to perform life-prolonging surgery and offer perioperative therapies with a patient's risk of contracting severe pneumonia if infected with SARS-CoV-2. The active surveillance strategy could be an alternative approach for clinically complete responders after neoadjuvant therapy in an effort to avoid possible exposure to COVID-19, which may be particularly beneficial considering the patients' immunosuppressed status [23] . Similarly to the organ-preserving approach in rectal cancer patients who present a complete response after neoadjuvant or definite therapies, the "active surveillance" pathways have been designed as a rationale for clinical complete responders after neoadjuvant chemoradiotherapy in the treatment of EC. Active surveillance versus immediate surgery in clinically complete responders after neoadjuvant chemoradiotherapy for esophageal cancer: a multicenter propensity matched study cache = ./cache/cord-297759-arg71du6.txt txt = ./txt/cord-297759-arg71du6.txt === reduce.pl bib === id = cord-296936-5gkx4jxa author = An, M. H. title = Treatment Response to Hydroxychloroquine and Antibiotics for mild to moderate COVID-19: a retrospective cohort study from South Korea date = 2020-07-07 pages = extension = .txt mime = text/plain words = 3788 sentences = 218 flesch = 49 summary = Results: Kaplan-Meier curves drawn using propensity score-matched data revealed no differences between the length of time to viral clearance and duration of hospital stay between the two treatment arms (p=0.18, p=0.088). Conclusions: HQ with antibiotics was not associated with better clinical outcomes in terms of time to viral clearance, length of hospital stay, and duration of symptoms compared to conservative treatment alone. There were significant differences between two groups before propensity score matching in all endpoints: time to viral clearance, hospital stay, and symptom duration ( Table 2) . This retrospective cohort study compared treatment response to two different treatment protocols in mild to moderate COVID-19 patients using several clinical outcome measures. HQ with antibiotics was not associated with better clinical outcomes and did not reduce time to viral clearance, length of hospital stays, and duration of symptoms compared to conservative treatment in mild to moderate COVID-19 patients. cache = ./cache/cord-296936-5gkx4jxa.txt txt = ./txt/cord-296936-5gkx4jxa.txt === reduce.pl bib === id = cord-297414-zq16s9ud author = Koh, Adrian H. C. title = What COVID-19 has taught us: lessons from around the globe date = 2020-06-13 pages = extension = .txt mime = text/plain words = 1777 sentences = 95 flesch = 51 summary = This was integrated with the NHI PharmaCloud System, which allowed thorough checks on the travel and medical history of preregistered patients for all outpatient clinic visits, day This article is part of a topical collection on Perspectives on COVID-19 surgery, scheduled examinations, or hospital admissions in advance [8] . Measures in the clinic include plastic barrier shields mounted to slit lamps and machines; all staff are asked to wear cap, eye goggles, protective clothing, surgical mask, and glove during clinic; video calls to check the patients with fever and red eye but not yet diagnosed with COVID at the emergency department. The fact is, telemedicine has been proposed and discussed for several decades before the COVID pandemic, but the current situation where many countries have imposed lockdowns and restrictions to travel to clinics and hospitals has greatly accelerated its use and implementation [10] . Virtual visits in ophthalmology: timely advice for implementation during the COVID-19 public health crisis cache = ./cache/cord-297414-zq16s9ud.txt txt = ./txt/cord-297414-zq16s9ud.txt === reduce.pl bib === id = cord-297836-y9vt6wvu author = Tan, Yi Quan title = Re: Kristian D. Stensland, Todd M. Morgan, Alireza Moinzadeh, et al. Considerations in the Triage of Urologic Surgeries During the COVID-19 Pandemic. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.027: The Forgotten Urological Patient During the COVID-19 Pandemic: Patient Safety Safeguards date = 2020-05-08 pages = extension = .txt mime = text/plain words = 768 sentences = 54 flesch = 45 summary = https://doi.org/10.1016/j.eururo.2020.03.027: The Forgotten Urological Patient During the COVID-19 Pandemic: Patient Safety Safeguards As described by Stensland et al [1] , urology services have been reduced significantly, with manpower and resources redeployed and reallocated to frontline departments, focusing attention to urgent-only cases during the COVID-19 pandemic [2] . In this letter, we add to the considerations provided by Stensland et al by highlighting important patient safety strategies and safeguards used at a tertiary urological centre amid the climate of resource scarcity during this pandemic. Our national university centre for organ transplantation maintained our cadaveric-donor and living-donor kidney transplantation programmes during this period, with rigorous protocols to screen donors and recipients for COVID-19 to prevent transmission to these immunocompromised patients. With the global focus on patients affected by COVID-19, appropriate levels of urological care must be maintained as patient safety safeguards, especially for certain vulnerable populations. cache = ./cache/cord-297836-y9vt6wvu.txt txt = ./txt/cord-297836-y9vt6wvu.txt === reduce.pl bib === id = cord-298067-awo3smgp author = Li, Huanjie title = Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report date = 2020-07-10 pages = extension = .txt mime = text/plain words = 4853 sentences = 268 flesch = 51 summary = Through associating infection symptoms with the transmission routes of virus and the patient course of the disease, we expect to provide guidelines for clinical diagnosis and the basis for suppressing the spread of the virus and antiviral treatment. On February 1, 2020, respiratory samples of four patients were confirmed SARS-CoV-2 infections by real-time PCR in Jinan Central Hospital, Shandong province, China. Summarizing the published articles, including SARS-CoV and SARS-CoV-2, we combined with epidemiological and clinical data to analyze the possible routes of asymptomatic patients with virus infection in order to provide the basis for suppressing the spread of the virus, and antiviral treatment and advice for the protection of medical staff. The study found that the detection of SARS-CoV-2 nucleic acid positive in a few feces of patients with confirmed COVID-19 cases indicated the presence of a live virus. cache = ./cache/cord-298067-awo3smgp.txt txt = ./txt/cord-298067-awo3smgp.txt === reduce.pl bib === id = cord-297494-6yxmaihl author = Katsurada, Naoko title = The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study date = 2017-12-06 pages = extension = .txt mime = text/plain words = 4336 sentences = 217 flesch = 38 summary = However, influenza virus A and B were associated with three-fold higher mortality in patients with chronic respiratory disease but not with other comorbidities (ARR 3.38, 95% CI 1.54–7.42). We conducted this prospective multicentre study to determine the distribution of viruses associated with pneumonia in adults and to establish their virus-specific effects on pneumonia mortality stratified by age group and comorbidity status. To the best of our knowledge, this study is the first to systematically investigate virus-specific effects on pneumonia mortality by age group and comorbidity status among adults. In our study, multiple viruses were identified in 5.1% of virus-associated pneumonia and were associated with higher mortality than single viral infection in patients with chronic respiratory disease and other comorbidities. Systematic reviews have shown that multiple viral infections in patients with respiratory disease are not associated with disease severity [27, 28] ; however, the majority of previous studies included young children but not adults. cache = ./cache/cord-297494-6yxmaihl.txt txt = ./txt/cord-297494-6yxmaihl.txt === reduce.pl bib === id = cord-297001-4g3wb8qi author = Tal, Shir title = Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? date = 2020-05-12 pages = extension = .txt mime = text/plain words = 4626 sentences = 236 flesch = 47 summary = Understanding the true impact of VTE on patients with COVID-19 will potentially improve our ability to reach a timely diagnosis and initiate proper treatment, mitigating the risk for this susceptible population during a complicated disease. However, many of the COVID-19 patients may present with high levels of D-dimer due to other causes -inflammation, disseminated intravascular coagulation, advanced age, or infection [23] suggesting the need for CTPA as an initial rule-out test as well. Finally, based on the correlation between high levels of D-dimer and severe COVID-19 disease [7, 37] as well as higher mortality rate [5, 38] , the International Society on Thrombosis and Haemosthasis (ISTH) and American Society of Hematology (ASH) guidelines [39] advises prophylactic LMWH in all hospitalized COVID-19 patients in the absence of any contraindications (active bleeding and platelet count less than 25 × 10 9 /L) [34, 40] . cache = ./cache/cord-297001-4g3wb8qi.txt txt = ./txt/cord-297001-4g3wb8qi.txt === reduce.pl bib === id = cord-298325-2gm4fnqi author = Shah, Sonia title = Novel use of home pulse oximetry monitoring in COVID‐19 patients discharged from the emergency department identifies need for hospitalization date = 2020-06-17 pages = extension = .txt mime = text/plain words = 4001 sentences = 245 flesch = 52 summary = title: Novel use of home pulse oximetry monitoring in COVID‐19 patients discharged from the emergency department identifies need for hospitalization OBJECTIVES: Our objective was to evaluate patient‐reported oxygen saturation (SpO(2)) using pulse oximetry as a home monitoring tool for patients with initially non‐severe COVID‐19 to identify need for hospitalization. CONCLUSIONS: This study found that home pulse oximetry monitoring identifies need for hospitalization in initially non‐severe COVID‐19 patients when a cut off of SpO(2) 92% is used. Our objective was to evaluate patient-reported oxygen saturation using pulse oximetry as a home monitoring tool for patients with initially non-severe COVID-19 to identify need for hospitalization. Our results found that pulse oximetry as a home monitoring tool identifies need for hospitalization in initially non-severe COVID-19 patients when a cut off of SpO 2 92% is used. This study found that home pulse oximetry monitoring identifies need for hospitalization in initially non-severe COVID-19 patients when resting home oxygen saturation drops below 92%. cache = ./cache/cord-298325-2gm4fnqi.txt txt = ./txt/cord-298325-2gm4fnqi.txt === reduce.pl bib === id = cord-298034-0ntxm28a author = Tepper, Joel E. title = Ethical Issues in Radiation Oncology During a Pandemic date = 2020-05-22 pages = extension = .txt mime = text/plain words = 1416 sentences = 75 flesch = 53 summary = Medicine in the United States has generally followed ethical principles espoused by Immanuel Kant where the individual patient takes priority in decision-making. With the advent of coronavirus disease 2019 as a major health event, radiation oncologists in some situations need to alter the manner in which they act with individual patients. The longstanding general ethical principles followed in the United States are based largely on concepts elucidated by Immanuel Kant and emphasize individual autonomy. Our US radiation oncology community fortunately rarely faces such emergency situations, but the present COVID-19 pandemic is forcing us to address serious ethical issues. We need to consider not just the impact of radiation therapy on that patient, but also the impact on other patients, health care workers, and society at large. Much cancer treatment is multi-modality, combining radiation therapy with surgery, chemotherapy, and/or immunotherapy, but it may be appropriate to alter standard sequencing in some situations. cache = ./cache/cord-298034-0ntxm28a.txt txt = ./txt/cord-298034-0ntxm28a.txt === reduce.pl bib === id = cord-298516-0eda4mzs author = Fadlallah, Ali title = LASIK procedures during COVID-19 date = 2020-08-05 pages = extension = .txt mime = text/plain words = 586 sentences = 44 flesch = 56 summary = This prospective study was performed in May 2020 following Dubai Health Care City Authority HSE protocol. 3 The preoperative phase started by taking the temperature of the patients, looking for symptoms such as cough or dyspnea, before they entered the center and by doing an intensive medical interview concerning any suspicious exposures or travels. Perioperatively, the procedure was performed in a sterilized environment; staff wore an N95 mask, sterile gloves, and a disposable gown, and patients wore a surgical mask. As for the staff of 7, no one tested COVID polymerase chain reaction positive before or after this study, and no one developed any of the aforementioned symptoms. In conclusions, after following an HSE plan adapted to the American Academy of Ophthalmology, the American College of Surgeons, and U.S. Centers for Disease Control and Prevention recommendations and guidelines, it might be safe to do short outpatient elective procedures requiring topical anesthesia if all personal protective equipment are available. cache = ./cache/cord-298516-0eda4mzs.txt txt = ./txt/cord-298516-0eda4mzs.txt === reduce.pl bib === id = cord-297518-6y2uzcde author = Leulseged, T. W. title = Determinants of Developing Symptomatic Disease in Ethiopian COVID-19 Patients date = 2020-10-13 pages = extension = .txt mime = text/plain words = 3323 sentences = 181 flesch = 50 summary = Results: The result of the multivariable binary logistic regression shows that age group (AOR= 1.818, 95% CI= 1.210, 2.731, p-value=0.004 for 30-39 years; AOR= 1.611, 95% CI= 1.016, 2.554, p-value=0.043 for 40-49 years and AOR= 4.076, 95% CI= 2.582, 6.435, p-value=0.0001 for years and above), sex (AOR= 1.672, 95% CI= 1.216, 2.299, p-value=0.002) and history of diabetes mellitus (AOR= 2.406, 95% CI= 1.384, 4.181, p-value=0.002) were found to be significant factors that determine the development of symptomatic disease in COVID-19 patients. . https://doi.org/10.1101/2020.10.09.20209734 doi: medRxiv preprint Therefore, the objective of this study was to assess the determinants of having symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia. Based on the chi-square/ Fischer's exact test result, a significant difference in the presence of symptom was found among the different age groups, sex, different COVID-19 severity, those with a history of pre-existing co-morbid illness, cardiac disease, hypertension, diabetes mellitus, asthma and the need of oxygen supplement. cache = ./cache/cord-297518-6y2uzcde.txt txt = ./txt/cord-297518-6y2uzcde.txt === reduce.pl bib === id = cord-297506-1xjgsz4y author = Jansen, Jaclyn H. title = A novel presentation of COVID-19 via community acquired infection date = 2020-03-31 pages = extension = .txt mime = text/plain words = 498 sentences = 39 flesch = 66 summary = COVID-19 is a novel coronavirus first detected in Wuhan, China in late 2019. A 76 year old male patient presented with his wife for altered mental status and lethargy. She reported the patient had not had fevers at home or dry cough, however she had recently experienced a dry cough. The patient had no known history of pulmonary disease. When vital signs were obtained the patient was found to have an oxygen saturation of 70% on room air. The patient was then weaned and able to maintain oxygen saturation of 93% on 5 L via nasal cannula. The patient was admitted to the progressive care unit for respiratory support and COVID-19 rule out. On follow-up, patient tested positive for COVID-19 with declining respiratory status over the next 24 h. Features, evaluation and treatment coronavirus (COVID-19) Update: public health response to the coronavirus disease 2019 outbreak -United States cache = ./cache/cord-297506-1xjgsz4y.txt txt = ./txt/cord-297506-1xjgsz4y.txt === reduce.pl bib === id = cord-298679-w0yp4u19 author = Iftimie, Simona title = Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain date = 2020-09-03 pages = extension = .txt mime = text/plain words = 3587 sentences = 184 flesch = 48 summary = Logistic regression analyses showed that fever, pneumonia, acute respiratory distress syndrome, diabetes mellitus and cancer were the variables that showed independent and statistically significant associations with mortality. This is one of the first studies to describe the factors associated with mortality in patients infected with SARS-CoV-2 in Spain, and one of the few in the Mediterranean area. The objective of the present study has been to characterize our patients' epidemiology and to identify the risk factors associated with mortality for this disease in our geographical area. Logistic regression analyses showed that the presence of fever, pneumonia, acute respiratory distress syndrome, type 2 diabetes mellitus and cancer were the only variables that showed an independent and statistically significant association with mortality when they were adjusted for differences in age, gender, smoking status and alcohol intake (Tables 2 and 3) . Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China cache = ./cache/cord-298679-w0yp4u19.txt txt = ./txt/cord-298679-w0yp4u19.txt === reduce.pl bib === id = cord-297840-z5l6vdsr author = Río, Francisco García title = Air Travel and Respiratory Disease date = 2007-02-28 pages = extension = .txt mime = text/plain words = 16164 sentences = 949 flesch = 54 summary = 57 In any case, to establish a medical opinion on risk in air travel, the type, reversibility, and degree of functional impairment caused by the disease must be assessed along with the tolerance of the patient for the predicted flight altitude and the length of exposure. Supplementary oxygen is recommended during air travel for patients who have an estimated in-flight PaO 2 of less then 50 mm Hg obtained with prediction equations or, preferably, a hypoxic challenge test ( Figure 6 ). It also seems wise to extend that treatment option to those cases and in which the in-flight cabin pressure corresponds to an altitude of greater than 2438 m (8000 feet) and the patient has very severe COPD (FEV 1 ≤30%), where limitations may be present in the mechanisms of compensation for hypoxemia, or diseases that alter oxygen transport. cache = ./cache/cord-297840-z5l6vdsr.txt txt = ./txt/cord-297840-z5l6vdsr.txt === reduce.pl bib === id = cord-297425-vcqqssm8 author = Aries, James A. title = Clinical Outcome of Coronavirus Disease 2019 in Haemato‐oncology Patients date = 2020-05-18 pages = extension = .txt mime = text/plain words = 1402 sentences = 76 flesch = 49 summary = However, the prognosis varies widely between groups, with age over 60 years and underlying conditions including hypertension, diabetes, cardiovascular disease and cancer identified as risk factors for severe disease and death.(3) The initial reports from China show that patients with cancer are over‐represented among individuals who develop severe Covid‐19 after contracting the virus.(4) Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy. (3) The initial reports from China show that patients with cancer are over-represented among individuals who develop severe Covid-19 after contracting the virus.(4) Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy. cache = ./cache/cord-297425-vcqqssm8.txt txt = ./txt/cord-297425-vcqqssm8.txt === reduce.pl bib === id = cord-298094-ctikhqvr author = Elias, Pierre title = The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19 date = 2020-08-15 pages = extension = .txt mime = text/plain words = 4165 sentences = 248 flesch = 52 summary = The principal findings of this study include: (1) rapid clinical deterioration is common in admitted patients, with 53% of intubations occurring within 48 hours, (2) 33% of admitted patients either died or required mechanical ventilation within fourteen days of COVID-19 diagnosis, and (3) combining abnormal ECG and abnormal respiratory vital signs quickly identifies a group of patients at high risk for mechanical ventilation or death. In this study, we sought to determine if data available early in a patient's emergency department presentation (demographics, comorbidities, vital signs, and ECG) could prognosticate the composite outcome of mechanical ventilation or death by 48 hours after COVID-19 diagnosis. In this study, we sought to determine if data available early in a patient's emergency department presentation (demographics, comorbidities, vital signs, and ECG) could prognosticate the composite outcome of mechanical ventilation or death by 48 hours after COVID-19 diagnosis. cache = ./cache/cord-298094-ctikhqvr.txt txt = ./txt/cord-298094-ctikhqvr.txt === reduce.pl bib === id = cord-298403-ilpzj2sv author = Mintz, Yoav title = Minimally Invasive Surgery is the Key to Patient and Operating room team Safety During the COVID19 Pandemic as well as in the “new normal” or chronic Pandemic State to come date = 2020-08-18 pages = extension = .txt mime = text/plain words = 745 sentences = 40 flesch = 35 summary = title: Minimally Invasive Surgery is the Key to Patient and Operating room team Safety During the COVID19 Pandemic as well as in the "new normal" or chronic Pandemic State to come In cases of emergency or oncological surgery the decision whether to perform abdominal surgery by laparotomy or laparoscopy is dependent on the COVID-19 status, the complexity of the operation, and the respiratory status. Patients with moderately compromised respiratory function requiring mask oxygen therapy or non-invasive ventilation (i.e. Continuous Positive Airway Pressure) can also be operated safely by laparoscopy. Patients with moderately to severely compromised respiratory function with interstitial pneumonia and ARDS, who are ventilated but have good respiratory system compliance (> 50 ml/cm H 2 O) can be safely operated via laparoscopy. At the present time, aside from the potential pulmonary repercussions, there is no evidence that laparoscopy is more dangerous than laparotomy for patients with COVID-19 disease 5 . cache = ./cache/cord-298403-ilpzj2sv.txt txt = ./txt/cord-298403-ilpzj2sv.txt === reduce.pl bib === id = cord-298056-svwtfshi author = Fabio, Ciceri title = Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy date = 2020-06-12 pages = extension = .txt mime = text/plain words = 3319 sentences = 169 flesch = 46 summary = Multivariable analysis showed older age, coronary artery disease, cancer, low lymphocyte count and high RALE score as factors independently associated with an increased risk of mortality. CONCLUSION: In a large cohort of COVID-19 patients of European origin, main risk factors for mortality were older age, comorbidities, low lymphocyte count and high RALE. 14 In this report we describe the demographical, clinical, radiological and laboratory characteristics, as well as the clinical outcomes and the risk factors for mortality, of the first 500 patients with COVID-19 admitted to San Raffaele Scientific Institute, a tertiary care academic hospital in Milan, Italy. With a clinical observation longer than one months from the last patient admitted, w e were able to identify early predictors of mortality related to patient characteristics, radiological and laboratory findings at hospital admission for COVID-19. cache = ./cache/cord-298056-svwtfshi.txt txt = ./txt/cord-298056-svwtfshi.txt === reduce.pl bib === id = cord-298787-4vo9gpiu author = Frost, Holly M. title = Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1–3 date = 2013-10-16 pages = extension = .txt mime = text/plain words = 3897 sentences = 238 flesch = 51 summary = A retrospective chart review and comparison of patients positive for HPIV types 1–4 by multiplex polymerase chain reaction between 2009 and 2012 at Children's Hospital Colorado was performed. Human parainfluenza viruses (HPIVs) are among the most common causes of acute respiratory tract infections in children [1] [2] [3] [4] [5] [6] . However, these studies have primarily been conducted outside North America and are limited by small sample sizes and often included patients with concurrent respiratory viral infections, making it difficult to assess the true clinical significance or epidemiology of HPIV-4 in pediatric patients. Previous studies have implicated HPIV-4 as a cause of upper and lower respiratory tract infections in children, but have not definitively demonstrated its epidemiology secondary to limited sample sizes [12, 18] . The study was performed at a large tertiary care children's hospital, most likely selecting the more seriously ill patients with HPIV infections. cache = ./cache/cord-298787-4vo9gpiu.txt txt = ./txt/cord-298787-4vo9gpiu.txt === reduce.pl bib === id = cord-299024-jkqdzt87 author = Mangner, Norman title = Paraneoplastic syndrome and SARS-CoV-2 – incremental effect of two thrombogenic conditions? date = 2020-10-21 pages = extension = .txt mime = text/plain words = 1071 sentences = 65 flesch = 40 summary = We present the case of a patient with a non-bacterial thrombotic aortic valve endocarditis experiencing severe thromboembolic complications and an acute right internal carotid artery occlusion in the context of a paraneoplastic syndrome and an asymptomatic SARS-CoV-2 infection, despite treatment with different and overlapping anticoagulant medication. This case describes a patient with non-bacterial thrombotic aortic valve endocarditis that developed despite treatment with a factor-Xa-inhibitor and who subsequently suffered a myocardial infarction and two strokes within a short period of time in the context of a paraneoplastic syndrome and asymptomatic SARS-CoV-2 infection. Paraneoplastic syndromes are often linked to increased thrombogenicity; however, non-bacterial thrombotic aortic valve endocarditis is rare even in the situation of cancer. 3 This case highlights the many-sided effects of paraneoplastic syndromes and SARS-CoV-2 infection in patients being already at increased risk for thrombotic complications due to underlying disease. cache = ./cache/cord-299024-jkqdzt87.txt txt = ./txt/cord-299024-jkqdzt87.txt === reduce.pl bib === id = cord-298894-t5hyfum3 author = Rifino, Nicola title = Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy date = 2020-10-07 pages = extension = .txt mime = text/plain words = 4682 sentences = 247 flesch = 44 summary = Neurological manifestations were classified as: (a) cerebrovascular disease [53 pts (38.7%)] including 37 ischemic and 11 haemorrhagic strokes, 4 transient ischemic attacks, 1 cerebral venous thrombosis; (b) peripheral nervous system diseases [31 (22.6%)] including 17 Guillain–Barrè syndromes; (c) altered mental status [49 (35.8%)] including one necrotizing encephalitis and 2 cases with RT-PCR detection of SARS-Cov-2 RNA in CSF; (d) miscellaneous disorders, among whom 2 patients with myelopathy associated with Ab anti-SARS-CoV-2 in CSF. COVID-19 diagnosis was confirmed: (1) by real-time reverse-transcriptase polymerase-chain-reaction (RT-PCR) on nasopharyngeal specimens [13] ; or (2) by RT-PCR on bronchoalveolar lavage (BAL) obtained by bronchoscopy in case of high clinical suspicion of SARS-CoV-2 infection and negative test results on at least two nasopharyngeal swabs performed at least 24 h apart; or (3) in the presence of characteristic radiological interstitial pneumonia associated with typical symptoms (fever, dry cough, dyspnea), even with negative RT-PCR, with no other possible aetiologic explanation. cache = ./cache/cord-298894-t5hyfum3.txt txt = ./txt/cord-298894-t5hyfum3.txt === reduce.pl bib === id = cord-298967-vjyh1xvh author = Bertossi, Dario title = Safety guidelines for non‐surgical facial procedures during covid‐19 outbreak date = 2020-06-07 pages = extension = .txt mime = text/plain words = 2005 sentences = 130 flesch = 51 summary = METHODS: A virtual meeting was conducted with the members (n=12) of the European Academy of Facial Plastic Surgery Focus Group to outline the safety protocol for the non‐surgical facial aesthetic procedures for aesthetic practices in order to protect the clinic staff and the patients from SARS‐CoV‐2 infection. While many medical Accepted Article practices are being run with online consultations 10 , some countries have recently decided to allow the opening of practices requiring one-on-one contact like dental, physiotherapy, for emergencies provided they strictly follow the guidelines detailing the infection control measures [12] [13] . In our largely elective field, both staff and resources should ideally be allocated through careful protocols in order to prevent COVID-19 infection. In response to this pandemic, our focus group has developed a process to stratify procedures and clinical levels with protocols that aim to minimize the risk of contagion and the diffusion of COVID-19 infection. cache = ./cache/cord-298967-vjyh1xvh.txt txt = ./txt/cord-298967-vjyh1xvh.txt === reduce.pl bib === id = cord-298974-69xjc5yq author = Adegboye, Oyelola A. title = Network Analysis of MERS Coronavirus within Households, Communities, and Hospitals to Identify Most Centralized and Super-Spreading in the Arabian Peninsula, 2012 to 2016 date = 2018-05-07 pages = extension = .txt mime = text/plain words = 4305 sentences = 190 flesch = 47 summary = The transmission connectivity networks of people infected with highly contagious Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia were assessed to identify super-spreading events among the infected patients between 2012 and 2016. e variables considered in this study were age, gender, patient type (whether the patient is a healthcare worker (HCW) or nonhealthcare worker), health outcome (dead or alive) as at the last day of follow-up, patient comorbidity status, types of exposure to known risk factors (animal contact and camel contact indirectly or directly or through consumption of camel products), and place of infection (classified as hospital, community, and household/ family). Patient 1664 was favoured (based on degree, closeness, betweenness, and eigenvector network centrality metrics) as the most important in the transmission network by having the highest number of secondary cases. In this study, several network centrality metrics (degree, betweenness, closeness, eigenvector, and 2-reach) were used to quantify the connectivity among MERS cases and to identify which patient requires prioritization for intervention. cache = ./cache/cord-298974-69xjc5yq.txt txt = ./txt/cord-298974-69xjc5yq.txt === reduce.pl bib === id = cord-297870-m7n43k4p author = Azevedo, Rafael Bellotti title = Covid-19 and the cardiovascular system: a comprehensive review date = 2020-07-27 pages = extension = .txt mime = text/plain words = 5108 sentences = 211 flesch = 30 summary = Moreover, as in other respiratory infections, preexisting CV diseases and risk factors can increase the severity of COVID-19, leading to the aggravation and decompensation of chronic underlying cardiac pathologies as well as acute-onset of new cardiac complications [3] , highlighting that myocardial injury can be present in approximately 12% of hospitalized patients with SARS-CoV-2 infection [1] . Within the CV manifestations of COVID-19, we can highlight four different aspects: (a) CV risk factors and established CV disease is associated with a worse prognosis, (b) appearance of acute CV complications in previously healthy individuals, (c) promising therapies with antimalarials and antivirals present important CV side effects, and (d) questioning the safety of the use of renin-angiotensin-aldosterone system (RAAS) inhibitors regarding an increased risk of COVID-19 [1] . cache = ./cache/cord-297870-m7n43k4p.txt txt = ./txt/cord-297870-m7n43k4p.txt === reduce.pl bib === id = cord-299082-s8bm40vy author = Wang, Yueying title = Cardiac arrhythmias in patients with COVID‐19 date = 2020-07-26 pages = extension = .txt mime = text/plain words = 3714 sentences = 247 flesch = 40 summary = 5, 6, 9, 10, [12] [13] [14] [15] Several investigators have reported cardiac function and structural abnormalities in patients with SARS-CoV-2 infection, including acute heart failure (HF), 3,10,16 takotsubo syndrome, 17 ,18 viral myocarditis, 19 and acute myocardial infarction. In addition to exacerbating the previous cardiomyopathy and conduction disorders, inducing arrhythmia events, SARS-CoV-2 may also induce electrophysiological abnormalities in patients with no previous history of heart disease under a variety of mechanisms. Clinical features and mechanism of heart injury in patients suffered from severe acute respiratory syndrome. Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19) cache = ./cache/cord-299082-s8bm40vy.txt txt = ./txt/cord-299082-s8bm40vy.txt === reduce.pl bib === id = cord-299489-6v225vte author = Gómez-Hernández, María Teresa title = TWICE LUCKY: ELDERLY PATIENT SURVIVING BOTH COVID-19 AND SERENDIPITOUS LUNG CARCINOMA date = 2020-07-25 pages = extension = .txt mime = text/plain words = 506 sentences = 32 flesch = 48 summary = So that, before transferring the patient we performed a new PCR test with a negative result. Once here, since the patient had not complied the 14 days of individual isolation after discharge, a serologic test was ordered to verify if the infection was active or passed; the result was positive, but unfortunately there was no possibility to know about which kind of immunoglobulins was elevated (Ig G or Ig M) due to the lack of reactants. Until a few days ago, only urgent procedures and high priority oncological elective surgery in non-COVID-19 patients were performed and always balancing the risk of delaying therapy against the availability of hospital resources and potential exposure of COVID-19 on a case-bycase basis. In addition, whenever possible, the elective surgical activity has been transferred to COVID-free areas to avoid potential contracting intra-hospital infections. Since previous reports have revealed that there are asymptomatic patients infected with SARS-CoV-2 (4,5), all patients needing a surgical intervention should be tested. cache = ./cache/cord-299489-6v225vte.txt txt = ./txt/cord-299489-6v225vte.txt === reduce.pl bib === id = cord-299681-smhto9em author = Elsaie, Mohamed L. title = Herpes zoster might be an indicator for Latent COVID 19 infection date = 2020-05-23 pages = extension = .txt mime = text/plain words = 691 sentences = 49 flesch = 54 summary = In this report we describe two cases COVID infection who first presented with herpes zoster. We are here by suggesting that the clinical presentation of HZ at the time of the current pandemic even in patients giving mild or no suggestive history of upper respiratory symptoms should be considered as an alarming sign for a recent subclinical SARS CoV2 infection. Most patients with COVID-19 exhibit mild to moderate symptoms, but approximately 15% of the cases progress to severe pneumonia and about 5% eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure (3, 4) . We present two cases of clinically diagnosed Herpes zoster infection attending two different clinics, both patients' showed no or mild symptoms of COVID 19 infection and denied any history of contact with known or suspected COVID19 cases. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan cache = ./cache/cord-299681-smhto9em.txt txt = ./txt/cord-299681-smhto9em.txt === reduce.pl bib === id = cord-299222-vmofcrim author = Rivas‐Pollmar, María Isabel title = Thromboprophylaxis in a patient with COVID‐19 and severe hemophilia A on emicizumab prophylaxis date = 2020-06-11 pages = extension = .txt mime = text/plain words = 1571 sentences = 78 flesch = 37 summary = All rights reserved Due to uncertainty about the risk of an increased prothrombotic state in CAC in association with emicizumab prophylaxis, thromboprophylaxis with low molecular weight heparin (LMWH), enoxaparin 40 mg once daily, was started. Bearing in mind the low risk of thrombosis with emicizumab in SHA without inhibitors, but because some of the mechanisms associated with the risk of thrombosis described above could be risk factors for the development of CAC, and in the absence of literature or guidelines for the management of such patients, our consensus clinical decision was to administer prophylactic doses of LMWH and to monitor laboratory parameters to follow up the disease and cytokine release storm. But we proposed the use of prophylactic dose of LMWH in SHA on emicizumab treatment at diagnosis, based on the low rate of bleeding complications associated with its cache = ./cache/cord-299222-vmofcrim.txt txt = ./txt/cord-299222-vmofcrim.txt === reduce.pl bib === id = cord-299570-1xz5r95f author = Martínez-García, M title = Telemedicina con telemonitorización en el seguimiento de pacientes con COVID-19 date = 2020-06-05 pages = extension = .txt mime = text/plain words = 1611 sentences = 159 flesch = 58 summary = Métodos: Estudio observacional prospectivo de los pacientes con diagnóstico de COVID-19 por PCR positiva y considerados de alto riesgo que se siguieron con telemedicina y telemonitorización en el Área Sanitaria de Lugo entre el 17 de marzo y el 17 de abril de 2020. Conclusiones: Nuestros datos sugieren que la telemedicina con telemonitorización domiciliaria, utilizada de forma proactiva, permite un seguimiento clínicamente útil y seguro en pacientes con COVID-19 de alto riesgo. Our study suggests that telemedicine with home telemonitoring, used proactively, allows for monitoring high-risk patients with COVID-19 in a clinically useful and secure way. Our study suggests that telemedicine with home telemonitoring, used proactively, allows for monitoring high-risk patients with COVID-19 in a clinically useful and secure way. Los datos de este estudio sugieren que el seguimiento domiciliario con telemedicina y telemonitorización en pacientes COVID-19 es un sistema bien aceptado, útil y seguro. cache = ./cache/cord-299570-1xz5r95f.txt txt = ./txt/cord-299570-1xz5r95f.txt === reduce.pl bib === id = cord-299124-g70v4crs author = Lancaster, Elizabeth M. title = Impact of the COVID-19 pandemic on an academic vascular practice and a multi-disciplinary limb preservation program date = 2020-09-12 pages = extension = .txt mime = text/plain words = 2176 sentences = 116 flesch = 51 summary = Early analysis of patient outcomes following pandemic-related practice changes suggest that patients with chronic limb threatening ischemia (CLTI) have been presenting with more severe foot infections and are more likely to require major limb amputation compared to 6 months prior. As our society and health care system adapt to the new changes required in the post-COVID era, it is critical that we pay special attention to the most vulnerable subsets of patients with vascular disease, particularly those with CLTI and limited access to care. Faculty, fellows, and residents provide care for vascular patients at the main UCSF campus as 10 well as two partner hospitals; the San Francisco Veteran Affairs (SFVA) Medical Center and 11 Providers prioritized in-person clinic visits for patients 9 with advanced lower extremity peripheral artery disease (PAD) with concern for CLTI (e.g. new 10 tissue loss), given that physical examination and vascular studies are essential for evaluation. cache = ./cache/cord-299124-g70v4crs.txt txt = ./txt/cord-299124-g70v4crs.txt === reduce.pl bib === id = cord-299333-qu0bmov5 author = Reddy, Gireesh B. title = Clinical Characteristics and Multisystem Imaging Findings of COVID-19: An Overview for Orthopedic Surgeons date = 2020-08-17 pages = extension = .txt mime = text/plain words = 4412 sentences = 235 flesch = 37 summary = Since December 2019, infections with severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), a novel betacoronavirus strain responsible for coronavirus disease 2019 (COVID19) , rapidly progressed from an isolated cluster of cases in the Hubei province of east central China to a pandemic, with significant global health and economic repercussions [4, 5, 10, 24, 25, 27, 28, 44, 58, 80, 91] . Early reports from Italy and China indicated that although pulmonary diseases including ARDS and diffuse pneumonia comprise the predominant lethal complications of COVID-19, patients have also presented with or developed significant cardiac signs and symptoms [50] . COVID-19 musculoskeletal and neurologic manifestations are being reported with increased frequency, particularly in patients with more severe respiratory disease, indicating coronavirus neurotropism possibly directly related with higher viral loads, which are now detectable in cerebrospinal fluid [20] . cache = ./cache/cord-299333-qu0bmov5.txt txt = ./txt/cord-299333-qu0bmov5.txt === reduce.pl bib === id = cord-299156-1dwsm3ie author = Shemer, Asaf title = Ocular involvement in coronavirus disease 2019 (COVID-19): a clinical and molecular analysis date = 2020-09-14 pages = extension = .txt mime = text/plain words = 3509 sentences = 214 flesch = 56 summary = The aim of this study was to assess the clinical and molecular ocular involvement among patients with confirmed COVID-19 admitted to a tertiary care facility. CONCLUSIONS: Among patients admitted to a tertiary referral center with confirmed COVID-19, active conjunctival injection was noted in one out of five cases, and was associated with loss of smell and taste. Among patients with COVID-19, active conjunctival injection was associated with loss of smell and loss of taste as part of the clinical presentation (66.7% vs 7.7%, p = 0.018). In this study, we evaluated the ocular signs and symptoms, as well as the presence of SARS-CoV-2 in conjunctival swab samples among patients with COVID-19 in one tertiary referral center during March and April of 2020. To conclude, among patients admitted to a tertiary referral center with confirmed COVID-19, active conjunctival injection was present in 19% of cases and was associated with loss of smell and taste as part of the clinical presentation. cache = ./cache/cord-299156-1dwsm3ie.txt txt = ./txt/cord-299156-1dwsm3ie.txt === reduce.pl bib === id = cord-299449-226dd23u author = Bernhardt, Denise title = Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas date = 2020-05-05 pages = extension = .txt mime = text/plain words = 4200 sentences = 221 flesch = 45 summary = It is acknowledged that the SARS-CoV-2 pandemic will require center specific discussions of appropriate resource allocation that considers patient and provider safety, resource constraints, and a realistic evaluation of the impact of therapy upon Incurable brain tumors. This international multidisciplinary group of experts in HGG provides a risk-adapted framework for decisions in both pandemic scenarios, considering both ethical issues and resource constraints, in order to minimize the irreparable damage associated with withholding necessary treatments. We recognize that during the pandemic the challenges of ICU capacity, conservation of PPE, availability of health care professional expertise and the risk for patients' exposure to SARS-CoV-2 may reduce the ability to provide optimal surgical management. Patients and caregivers should be included in the decision-making process as much as possible, and this should include all relevant data on chemotherapy and radiotherapy, as well as the individual risk profile associated with a potential SARS-CoV-2 infection. cache = ./cache/cord-299449-226dd23u.txt txt = ./txt/cord-299449-226dd23u.txt === reduce.pl bib === id = cord-300038-1fjb6b8e author = Cantini, Fabrizio title = Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact date = 2020-04-23 pages = extension = .txt mime = text/plain words = 1261 sentences = 81 flesch = 48 summary = According to a recent report 3 , COVID-19, the disease caused by SARS-CoV-2, is characterized by three clinical patterns: no symptoms, mild to moderate disease, severe pneumonia requiring admission to Intensive Care Unit (ICU) in up to 31% of the patients 3 . On this basis, we assessed the safety of baricitinib therapy combined with lopinavir-ritonavir in moderate COVID-19 pneumonia patients and we evaluated its clinical impact. All consecutive hospitalized patients (March 16 th -30 th ) with moderate COVID-19 pneumonia, older than 18 years, were treated for 2 weeks with baricitinib tablets 4 mg/day added to ritonavirlopinavir therapy. The last consecutive patients with moderate COVID-19 pneumonia receiving standard of care therapy (lopinavir/ritonavir tablets 250 mg/bid and hydroxychloroquine 400 mg/day/orally for 2 weeks) admitted before the date of the first baricitinib-treated patient served as controls. These preliminary results on 12 patients with moderate COVID-19 pneumonia confirmed the safety of baricitinib therapy in a clinical context different from RA 7 . cache = ./cache/cord-300038-1fjb6b8e.txt txt = ./txt/cord-300038-1fjb6b8e.txt === reduce.pl bib === id = cord-299835-92karhpl author = Ho, Khek Y. title = Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore date = 2004-02-17 pages = extension = .txt mime = text/plain words = 3524 sentences = 163 flesch = 52 summary = title: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore Participating HCWs completed a questionnaire and provided paired serum samples, which were analyzed by 2 different laboratories blinded to clinical data, by use of an enzyme-linked immunosorbent assay based on a protocol developed by the Centers for Disease Control and Prevention and a dot-blot immunoassay, with confirmation by a viral neutralization assay. Of the 372 HCWs participating in the present study, 8 were found to have positive antibodies to the SARS coronavirus in both samples by use of both test methods, and 6 had pneumonia and had been hospitalized for either probable or suspected SARS infection, whereas 2 had fever but did not have changes on chest radiographs. cache = ./cache/cord-299835-92karhpl.txt txt = ./txt/cord-299835-92karhpl.txt === reduce.pl bib === id = cord-299881-weptfpa2 author = Halvachizadeh, Sascha title = The impact of SARS-CoV-2 (COVID-19) pandemic on trauma bay management and guideline adherence in a European level-one-trauma centre date = 2020-07-28 pages = extension = .txt mime = text/plain words = 3332 sentences = 179 flesch = 45 summary = This study aims to work out potential adjustments of trauma bay algorithms during a global pandemic in order to reduce contamination and to increase safety for patients and medical personnel. In order to contain spreading of SARS Cov-2, the suggested recommendations of adjusting trauma bay protocols for severely injured patients include (1) minimizing trauma bay team members with direct contact to the patient; (2) reducing repeated examination as much as possible, with rationalized use of protective equipment; and (3) preventing potential secondary inflammatory insults. These guidelines include recommendations for the minimum number of required medical professionals in the trauma bay (e.g., anesthesiologists, traumatologist, neurosurgeons, nurses, technicians etc..), initial assessments according to Advanced Trauma Life Support (e.g., blood pressure measurements, respiratory rate, auscultation and examination of body regions, etc.), and settings around the trauma bay management, such as operation room or computer tomography availability [5, 6] . cache = ./cache/cord-299881-weptfpa2.txt txt = ./txt/cord-299881-weptfpa2.txt === reduce.pl bib === id = cord-300356-oorac5he author = Nair, Girish B. title = Community-Acquired Pneumonia: An Unfinished Battle date = 2011-10-05 pages = extension = .txt mime = text/plain words = 7378 sentences = 340 flesch = 41 summary = 20 Risk factors for community-acquired P aeruginosa pneumonia include bronchiectasis, immunocompromised state, use of multiple courses of antibiotics, prolonged glucocorticoids in patients with COPD, and recent hospitalization. One of the most important decisions in the management of pneumonia is to assess the severity of the disease, which can be used to predict mortality risk and may be Nair & Niederman a surrogate measure to define the site of care (outpatient, hospital ward, or ICU). 61, 62 Although administration of therapy within 4 to 6 hours of arrival at the hospital can reduce mortality, it is important to only use antibiotics when the diagnosis is certain, because indiscriminate use of antibiotics in the absence of radiographic pneumonia has limited benefit and a real risk of Community-Acquired Pneumonia antibiotic-associated adverse events, including drug-induced infectious diarrhea. cache = ./cache/cord-300356-oorac5he.txt txt = ./txt/cord-300356-oorac5he.txt === reduce.pl bib === id = cord-299621-m4kdkmey author = Kumar, A. title = Outbreak of Middle East respiratory syndrome coronavirus, Saudi Arabian experience date = 2017-08-31 pages = extension = .txt mime = text/plain words = 1869 sentences = 84 flesch = 41 summary = Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified from a 60-year-old Saudi male patient admitted to a private hospital in Jeddah, Saudi Arabia on June13, 2012, with history of fever, cough, expectoration, and shortness of breath who eventually expired 11 days after admission from progressive respiratory failure. In April 2012, a cluster of cases of pneumonia occurred in health care workers of an intensive care unit in a hospital in Zarqa, Jordan, of which 2 patients died, both of whom were confirmed to be infected with the novel coronavirus by retrospective analysis of stored sample. New respiratory illness room with portable High efficiency particulate arrestors (HEPA) was created to isolate suspected MERS-CoV infected patients within the Emergency Medical Services. Until date (July 2017), there are no healthcare associated MERS-CoV Infection among patients, visitors and HCWs of our hospital and improved compliance with the IPC policies and procedures were achieved. cache = ./cache/cord-299621-m4kdkmey.txt txt = ./txt/cord-299621-m4kdkmey.txt === reduce.pl bib === id = cord-299750-zkrlm3ds author = Cui, Wei title = Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China date = 2010-05-31 pages = extension = .txt mime = text/plain words = 4965 sentences = 273 flesch = 52 summary = We describe the clinical characteristics and factors associated with the death of patients who were hospitalized with 2009 H1N1 influenza pneumonia in Shenyang, China, from November to December 2009. Therefore, this report summarizes the clinical manifestations, clinical outcomes and the risk factors associated with death in hospitalized pneumonia patients associated with 2009 H1N1 influenza infections in Shenyang, China, during November to December 2009. They used a standardized form that included demographic data, seasonal influenza vaccination history for the previous year, smoking status, underlying medical conditions, clinical signs and symptoms, selected laboratory tests including C reactive protein (CRP), white blood cell classification and count, lactic dehydrogenase (LDH), creatine kinase (CK), glutamic-oxaloacetic transaminase (AST), glutamic alanine aminotransferase (ALT), albumin (Alb), CD4, CD8 and CD3 T cell counts, blood gas analyses, blood or sputum cultures, radiographic findings, intervals between symptom onset and initiation of oseltamivir therapy, treatment course and length of stay. cache = ./cache/cord-299750-zkrlm3ds.txt txt = ./txt/cord-299750-zkrlm3ds.txt === reduce.pl bib === id = cord-299254-kqpnwkg5 author = Sun, Yingcheng title = INSMA: An integrated system for multimodal data acquisition and analysis in the intensive care unit date = 2020-04-28 pages = extension = .txt mime = text/plain words = 4608 sentences = 210 flesch = 41 summary = In this paper, we proposed a multimodal data acquisition and analysis system called INSMA, with the ability to acquire, store, process, and visualize multiple types of data from the Philips IntelliVue patient monitor. Enormous volumes of multimodal physiological data are generated including physiological waveform signals, patient monitoring alarm messages, and numerics and if acquired, synchronized and analyzed, this data can been effectively used to support clinical decision-making at the bedside [10, 18] . We have been working on building the Integrated Medical Environment (tIME) [10] to address this critical opportunity and in this paper, we discuss an integrated system (INSMA) that supports multimodal data acquisition, parsing, real-time data analysis and visualization in the ICU. Advances in informatics, whether through data acquisition, physiologic alarm detection, or signal analysis and visualization for decision support have the potential to markedly improve patient treatment in ICUs. Clinical monitors have the ability to collect and visualize important numerics or waveforms, but more work is needed to interface to the monitors and acquire and synchronize multimodal physiological data across a diverse set of clinical devices. cache = ./cache/cord-299254-kqpnwkg5.txt txt = ./txt/cord-299254-kqpnwkg5.txt === reduce.pl bib === id = cord-300344-57vxlctl author = Roof, Kevin S. title = Virtual On Treatment Visits: Implementation, Patient Perspectives, Barriers, Limitations, Benefits and Opportunities. date = 2020-10-16 pages = extension = .txt mime = text/plain words = 4337 sentences = 241 flesch = 52 summary = PURPOSE: To report our initial experience with weekly tele-video "virtual" on treatment visits (vOTVs), describe the logistics of implementation, report results of patient and physician surveys, and discuss barriers, limitations, and benefits of vOTVs during the COVID-19 pandemic. Physicians participating in the vOTVs felt very comfortable in their ability to manage patients though this platform (5.0), and on average did not report any difference in terms of efficiency of visits (3.0). Our experience suggests that vOTVs can be implemented rapidly using available technology, and with a high degree of patient and physician satisfaction during this pandemic with similar efficiency to in person OTVs. COVID-19 can cause serious illness or death, particularly in high risk groups. In an effort to further minimize patient, and staff risk of COVID-19 exposure, the American Society for Radiation Oncology (ASTRO) lobbied for coverage of virtual on treatment visits (vOTVs). cache = ./cache/cord-300344-57vxlctl.txt txt = ./txt/cord-300344-57vxlctl.txt === reduce.pl bib === id = cord-300995-tqz2bkdo author = Tagliaferri, Luca title = Skin cancer triage and management during COVID‐19 pandemic date = 2020-04-25 pages = extension = .txt mime = text/plain words = 1411 sentences = 65 flesch = 45 summary = The worldwide medical community is striving to pursue the most appropriate clinical choices in the worst event of pandemic of the modern times [1], with over 1 million patients affected by COVID‐19 (i.e., swab positive patients with or without symptoms) reported so far [1]. The worldwide medical community is striving to pursue the most appropriate clinical choices in the worst event of pandemic of the modern times [1] , with over 1 million patients affected by COVID-19 (i.e., swab positive patients with or without symptoms) reported so far [2] . All rights reserved We therefore propose that the oncological risk and the risk of SARS-CoV-2 infection need to be considered and balanced in order to provide a weighted and controlled strategy to advanced skin cancer patients. A useful approach, as already suggested by other authors, is to identify the different classes of priorities, both for the patients and for health professionals [5, 6] .Only a few national and international societies have released specific recommendations for skin cancer patients [7] . cache = ./cache/cord-300995-tqz2bkdo.txt txt = ./txt/cord-300995-tqz2bkdo.txt === reduce.pl bib === id = cord-300044-vn4c6wh7 author = Kim, Ji Won title = From White Count to White Out() date = 2015-08-05 pages = extension = .txt mime = text/plain words = 2848 sentences = 182 flesch = 43 summary = Rare causes, such as pneumonia from atypical agents from an undiagnosed immunodeficiency, congenital heart disease, methemoglobinemia, and pulmonary malformations, should be entertained as possible components of the differential diagnosis in the ED. In this child, the differential diagnosis narrows significantly to a pulmonary etiology in a patient who had infiltrates on chest radiograph and whose respiratory distress and hypoxia responded readily to supplemental oxygen, making the diagnosis of congenital heart disease unlikely. Viral bronchiolitis typically presents with upper respiratory symptoms followed by lower respiratory infection resulting in wheezing and rales in children younger than two years of age. 1 Pneumonia is another common cause of hypoxia and respiratory distress in children and can be the result of both bacterial and viral infections. 6, 7 PCP is one of the opportunistic infections with which patients with Hyper IgM syndrome may present. cache = ./cache/cord-300044-vn4c6wh7.txt txt = ./txt/cord-300044-vn4c6wh7.txt === reduce.pl bib === id = cord-299679-6z9e5gi6 author = Rello, Jordi title = Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers date = 2020-05-21 pages = extension = .txt mime = text/plain words = 1961 sentences = 112 flesch = 37 summary = Many intubated patients present with phenotype 4, characterised by pulmonary hypoxic vasoconstriction, being associated with severe hypoxaemia with "normal" (>40 mL·cmH(2)O(−1)) lung compliance and likely representing pulmonary microvascular thrombosis. Phenotype 5 is often associated with high plasma procalcitonin and has low pulmonary compliance, Which is a result of co-infection or acute lung injury after noninvasive ventilation. The clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is broad, ranging from asymptomatic infection to flu-like illness (sometimes with digestive disturbances) to viral pneumonia. Phenotype 2 represents 80% of hospitalisations and is characterised by the presence of hypoxaemia or small opacities on chest radiographs and these patients should be referred for close respiratory monitoring ( particularly respiratory rate and oxygen saturation measure by pulse oximetry) because they are at risk of rapid deterioration progressing to death if intubation is not timely instituted. cache = ./cache/cord-299679-6z9e5gi6.txt txt = ./txt/cord-299679-6z9e5gi6.txt === reduce.pl bib === id = cord-299784-xxxdjfbc author = Bettari, Luca title = Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting date = 2020-04-10 pages = extension = .txt mime = text/plain words = 747 sentences = 59 flesch = 47 summary = title: Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting The correct management of patients with coronavirus disease 2019 and acute coronary syndrome is still uncertain. We describe the percutaneous treatment of an unprotected left main coronary artery in a patient who is positive for coronavirus disease 2019 with unstable angina, dyspnea and fever. The use of the Impella CP cardiac assist system to provide left ventricular support during high-risk percutaneous coronary interventions is recommended in such settings, because its efficacy is supported by randomized@LBettari. Realworld use of the Impella 2.5 circulatory support system in complex high-risk percutaneous coronary intervention: the USpella Registry Supported high-risk percutaneous coronary intervention with the Impella 2.5 device the Europella registry KEY WORDS COVID-19, high-risk PCI, personal protection equipment APPENDIX For supplemental videos, please see the online version of this paper Personal Protection During High-Risk PCI in a COVID-19 Patient cache = ./cache/cord-299784-xxxdjfbc.txt txt = ./txt/cord-299784-xxxdjfbc.txt === reduce.pl bib === id = cord-300608-eju7wnb9 author = Sheervalilou, Roghayeh title = COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease date = 2020-05-26 pages = extension = .txt mime = text/plain words = 7391 sentences = 384 flesch = 47 summary = 2.1 | Respiratory system SARS-CoV-2 tends to infect the respiratory tract, thus, pneumonia is a primary clinical finding in patients with COVID-19 Li, Guan, et al., 2020; Zhu et al., 2020) . A number of investigations recently conducted on COVID-19 have reported that IL-6 levels was actually higher in the patients with severe disease (Cai, 2020; Chen, Liu, et al., 2020; Xiang et al., 2020) . Impaired liver function tests have been reported for a number of patients with SARS-CoV-2 infection, suggesting hepatic damage as an extrapulmonary complication of COVID-19 in almost one half of the patients (Chen, Zhou, et al., 2020; Wang, Hu, et al., 2020) . Since H7N9 and SARS-CoV-2 can result in similar complications, for example, ARDS and respiratory failure, MSC-based therapy might lead to a new path in treatment of COVID-19-associated pneumonia . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan cache = ./cache/cord-300608-eju7wnb9.txt txt = ./txt/cord-300608-eju7wnb9.txt === reduce.pl bib === id = cord-300774-5mrkmctl author = Hernández-Mora, Miguel Górgolas title = Compassionate Use of Tocilizumab in Severe SARS-CoV2 Pneumonia date = 2020-10-25 pages = extension = .txt mime = text/plain words = 4340 sentences = 230 flesch = 50 summary = INTRODUCTION: Tocilizumab is an interleukin 6 receptor antagonist which has been used for the treatment of severe SARS-CoV-2 pneumonia (SSP), aiming to ameliorate the cytokine release syndrome (CRS) -induced acute respiratory distress syndrome (ARDS). Patients with severe SARS-CoV-2 pneumonia (SSP) die due to poor oxygenation despite ventilatory support and different treatments including drugs with anti-viral activity, such as remdesivir, lopinavir/ritonavir, interferon beta, hydroxychloroquine; and/or anti-inflammatory drugs, such as corticosteroids, azithromycin and low molecular weight heparin amongst other [2] [3] [4] [5] . However, clinical and pathological studies of SARS-CoV-2 disease indicate that a systemic cytokine storm due to macrophage activation may be the leading cause of death in the vast majority of patients, usually occurring two to four weeks after primary infection [14] [22] [23] . cache = ./cache/cord-300774-5mrkmctl.txt txt = ./txt/cord-300774-5mrkmctl.txt === reduce.pl bib === id = cord-300559-vuuxthx2 author = Deng, Ming title = Obesity as a Potential Predictor of Disease Severity in Young COVID‐19 Patients: A Retrospective Study date = 2020-06-29 pages = extension = .txt mime = text/plain words = 4164 sentences = 251 flesch = 53 summary = Logistic regression analysis showed that male, high body mass index (especially obesity), elevated fasting blood glucose and urinary protein positive are all risk factors for severe young COVID‐19 patients. The analysis showed that a high body mass index (especially obesity), an elevated FBG level, an elevated LDH level, and urinary protein positivity were all risk factors for severe COVID-19 in these young patients. A recently published study from China also showed that in metabolic-associated fatty liver disease patients, obesity can increase the risk for severe COVID-19 by about 6-fold [22] . Notably, in the present study, all of the severely or critically ill COVID-19 patients were males, an observation which may also be related to the distribution of obesity in China. Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease cache = ./cache/cord-300559-vuuxthx2.txt txt = ./txt/cord-300559-vuuxthx2.txt === reduce.pl bib === id = cord-299346-f13xly6q author = Awad, Mohamed E. title = Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed Coronavirus Disease 2019 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current Coronavirus Disease 2019 Pandemic date = 2020-04-10 pages = extension = .txt mime = text/plain words = 4216 sentences = 254 flesch = 42 summary = title: Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed Coronavirus Disease 2019 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current Coronavirus Disease 2019 Pandemic To reduce the occupational risk in treating suspected or confirmed COVID-19 urgent orthopaedic patients, recommended precautions and preventive actions (triage area, ED consultation room, induction room, operating room, and recovery room) are reviewed. HCPs in high-risk areas should adhere to infection prevention and control practices, which includes the appropriate use of engineering controls (negative pressure rooms), administrative controls, and personal protective equipment (PPE) ( 6 Per CDC recommendations, a clinically suspected/ confirmed COVID-19 patient should wear a cloth face covering, over nose, and mouth and a surgical mask should be reserved for HCP and first responders. It is recommended for an environmental services worker to increase the Flowchart demonstrating the the recommended use of personal protective equipment for different activities at various settings managing suspected/clinically Coronavirus disease 2019 patients. cache = ./cache/cord-299346-f13xly6q.txt txt = ./txt/cord-299346-f13xly6q.txt === reduce.pl bib === id = cord-300866-cso6l6ze author = Bao, Yi title = Clinical Features of COVID-19 in a Young Man with Massive Cerebral Hemorrhage—Case Report date = 2020-05-23 pages = extension = .txt mime = text/plain words = 4252 sentences = 217 flesch = 50 summary = Both SARS-CoV-2 nucleic acid tests were negative (24 h interval), Fig. 2 The treatment of COVID-19 patients with intracerebral hemorrhage suggesting that antiviral treatment was effective. On February 29, the patient did not have high fever again, the results of the cerebrospinal fluid review showed that it was light red, no clot, protein decreased to 0.8 g/L, sugar increased to 4.45 mmol/L, and white blood cells decreased to 37 × 10 6 G/L, of which monocytes accounted for 74%. The patient's cerebrospinal fluid showed improvement, and since the two re-examinations of SARS-CoV-2 nucleic acid test was negative, and the antiviral treatment with Abidol, Ribavirin, and Oseltamivir had reached the course of treatment, so it was discontinued. However, in combination with the patient's high fever, lymphocytopenia, increased neutrophils, and poor antibacterial treatment effect, the clinical manifestations conform to the COVID-19 characteristics, and nucleic acid detection is required. cache = ./cache/cord-300866-cso6l6ze.txt txt = ./txt/cord-300866-cso6l6ze.txt === reduce.pl bib === id = cord-301011-xbuqd0j5 author = Felten-Barentsz, Karin M title = Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19 date = 2020-06-18 pages = extension = .txt mime = text/plain words = 3952 sentences = 259 flesch = 39 summary = In line with international initiatives, this article aims to provide guidance and detailed recommendations for hospital-based physical therapists managing patients hospitalized with COVID-19 through a national approach in the Netherlands. A working group conducted a purposive scan of the literature and drafted initial recommendations based on the knowledge of symptoms in patients with COVID-19, and current practice for physical therapist management for patients hospitalized with lung disease and patients admitted to the intensive care unit (ICU). 12 In line with this international study 12 and the consensus statement of Italian respiratory therapists 13 we aim to provide guidance and detailed recommendations for hospital-based physical therapists managing patients hospitalized with COVID-19 through a national approach in the Netherlands. Physical therapist management for patients hospitalized with COVID-19 comprises elements of respiratory support and active mobilization. Physical therapist management for patients hospitalized with COVID-19 comprises elements of respiratory support and active mobilization. cache = ./cache/cord-301011-xbuqd0j5.txt txt = ./txt/cord-301011-xbuqd0j5.txt === reduce.pl bib === id = cord-300183-z3fwtwqb author = Ahmed, Taha title = Community and healthcare system-related factors feeding the phenomenon of evading medical attention for time-dependent emergencies during COVID-19 crisis date = 2020-08-25 pages = extension = .txt mime = text/plain words = 3444 sentences = 214 flesch = 50 summary = Moreover, a comprehensive review of literature is performed to illustrate the potential factors delaying and decreasing timely presentations and interventions for time-dependent medical emergencies like ST-segment elevation myocardial infarction (STEMI). Moreover, a comprehensive review of literature is performed to illustrate the potential factors delaying and decreasing timely presentations and interventions for time-dependent medical emergencies like ST-segment elevation myocardial infarction (STEMI). There is a delay and decrease in presentations and timely interventions for medical emergencies like STEMI during the current era of COVID-19 crisis. ► Several community and healthcare-system-related factors delay and decrease the presentation and intervention for time-dependent non-communicable diseases such as STsegment elevation myocardial infarction (STEMI) in the era of COVID-19 crisis. Delayed Presentation of Acute ST Segment Elevation Myocardial Infarction Complicated with Heart Failure in the Period of COVID-19 Pandemic -Case Report Complication of late presenting STEMI due to avoidance of medical care during the COVID-19 pandemic cache = ./cache/cord-300183-z3fwtwqb.txt txt = ./txt/cord-300183-z3fwtwqb.txt === reduce.pl bib === id = cord-300510-fhpkdqr0 author = Mojoli, Francesco title = Our recommendations for acute management of COVID-19 date = 2020-05-08 pages = extension = .txt mime = text/plain words = 1083 sentences = 73 flesch = 41 summary = 7. Perform early intubation if poor response to continuous positive airway pressure in terms of oxygenation: do not trust patients' relatively good respiratory mechanics and feeling of improved dyspnoea, since these patients may have relatively normal lung compliance and the only clinical sign of fatigue may be high respiratory rate. As soon as possible according to gas exchanges (PaO 2 /FiO 2 > 150 with FiO2 < 50%) and lung ultrasound score (≤ 12), start assisted ventilation with a sigh while maintaining moderate to high positive end-expiratory pressure to prevent derecruitment. Abbreviations SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2; ICU: Intensive care unit Assessment of lung aeration and recruitment by CT scan and ultrasound in acute respiratory distress syndrome patients Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China The authors read and approved the final manuscript. cache = ./cache/cord-300510-fhpkdqr0.txt txt = ./txt/cord-300510-fhpkdqr0.txt === reduce.pl bib === id = cord-300697-p96i25uc author = Chen, Taojiang title = A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report date = 2020-09-29 pages = extension = .txt mime = text/plain words = 2182 sentences = 128 flesch = 43 summary = title: A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report CASE PRESENTATION: We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Additionally, despite the clinical manifestations of coronavirus disease 2019 (COVID-19) are dominated by respiratory symptoms, evidences from recent studies have suggested that SARS-CoV-2 has the ability to actively infect and replicate in the gastrointestinal tract [3] . Herein, we described an old-aged COVID-19 patient with multiple risk factors for severe disease and ultimately died from massive GIB at Wuhan Union Hospital. cache = ./cache/cord-300697-p96i25uc.txt txt = ./txt/cord-300697-p96i25uc.txt === reduce.pl bib === id = cord-300458-jeuwaj50 author = Maisch, Bernhard title = COVID-19—What we know and what we need to know: There are more questions than answers date = 2020-04-23 pages = extension = .txt mime = text/plain words = 1156 sentences = 73 flesch = 57 summary = COVID-19-What we know and what we need to know: There are more questions than answers This collection of short statements from the editors of HERZ/Cardiovascular Diseases is a strong signal to the readers of our journal in critical times. But we also fear that with a low herd immunity a second wave of infection might follow, since no proven antiviral treatment for COVID-19 exists and vaccination is not yet available [3] . Pulmonology demonstrates with every ventilated patient that COVID-19 is a potentially lethal lung disease. The first reported Chinese patient with suspected myocarditis from SARS-CoV-2 was treated with ventilation, methylprednisolone, i.v. immunoglobulins and inotropics and survived [4] . A total of 55 authors (!) have described in an observational study with 66 COVID-19 patients without a control group a beneficial effect in the New England Journal of Medicine [5] . 2020) compassionate use of remdesivir for patients with severe Covid-19 cache = ./cache/cord-300458-jeuwaj50.txt txt = ./txt/cord-300458-jeuwaj50.txt === reduce.pl bib === id = cord-300445-qzu4gz2d author = Zhang, Xiao-lei title = Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives date = 2020-09-23 pages = extension = .txt mime = text/plain words = 7247 sentences = 376 flesch = 37 summary = Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. However, chloroquine phosphate and its derivative hydroxychloroquine, which have been used for decades in the treatment and prevention of malaria and chronic inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, were discovered to have a high inhibitory potency against SARS-CoV-2 infection in vitro [2] [3] [4] [5] and favorable clinical and virologic benefits in COVID-19 patients [6] [7] [8] [9] [10] , and they have emerged as important therapies for COVID-19 in several countries, including China, France, USA, and India, although the mechanisms of their anti-COVID-19 effects remain unclear. cache = ./cache/cord-300445-qzu4gz2d.txt txt = ./txt/cord-300445-qzu4gz2d.txt === reduce.pl bib === id = cord-300080-l0fyxtva author = Venkat, Arvind title = Ethical Issues in the Response to Ebola Virus Disease in US Emergency Departments: A Position Paper of the American College of Emergency Physicians, the Emergency Nurses Association and the Society for Academic Emergency Medicine date = 2015-03-10 pages = extension = .txt mime = text/plain words = 8369 sentences = 336 flesch = 43 summary = With the presentation of patients with Ebola to US acute care facilities, ethical questions have been raised in both the press and medical literature as to how US emergency departments, emergency physicians, emergency nurses and other stakeholders in the healthcare system should approach the current epidemic and its potential for spread in the domestic environment. With the presentation of patients with Ebola to US acute care facilities, ethical questions have been raised in both the press and medical literature as to how US emergency departments, emergency physicians, emergency nurses and other stakeholders in the healthcare system should approach the current epidemic and its potential for spread in the domestic environment. WHAT 41 It is anticipated that patients with a confirmed EVD diagnosis will be transferred to these hospitals which will have enough PPE and other treatment requirements (isolation rooms, dedicated equipment and designated physicians, nurses and other necessary health care professionals and staff with proper training under CDC guidelines) to manage patients for at least 7 days, after which governmental agencies would assist in acquiring more supplies and expertise if needed. cache = ./cache/cord-300080-l0fyxtva.txt txt = ./txt/cord-300080-l0fyxtva.txt === reduce.pl bib === id = cord-300303-d4qmtysd author = de Azambuja, Evandro title = ESMO Management and treatment adapted recommendations in the COVID-19 era: Breast Cancer date = 2020-05-20 pages = extension = .txt mime = text/plain words = 6968 sentences = 292 flesch = 34 summary = The global preparedness and response to the rapid escalation to severe acute respiratory syndrome coronavirus (SARS-CoV)-2-related disease (COVID-19) to a pandemic proportion has demanded the formulation of a reliable, useful and evidence-based mechanism for health services prioritisation, to achieve the highest quality standards of care to all patients. The global preparedness and response to the rapid escalation to severe acute respiratory syndrome coronavirus (SARS-CoV)-2-related disease to a pandemic proportion has demanded the formulation of a reliable, useful and evidence-based mechanism for health services prioritisation, to achieve the highest quality standards of care to all patients. The global preparedness and response to the rapid escalation of severe acute respiratory syndrome coronavirus (SARS-CoV)-2-related disease at a pandemic proportion has demanded the prompt development of a reliable, applicable and evidenceinformed mechanism for the priority-setting of health services, to assure the attainment of the highest standards of quality care to all. cache = ./cache/cord-300303-d4qmtysd.txt txt = ./txt/cord-300303-d4qmtysd.txt === reduce.pl bib === id = cord-301079-n1nytr6k author = Tan, Li title = Air and surface contamination by SARS-CoV-2 virus in a tertiary hospital in Wuhan, China date = 2020-07-27 pages = extension = .txt mime = text/plain words = 3556 sentences = 205 flesch = 60 summary = Results A total of 367 air and surface swabbing samples were collected from the patient care areas of 15 mild and 9 severe/critical COVID-19 patients. Here we collected air and surface samples from isolation wards and ICU units of a tertiary hospital in Wuhan, with the aim to evaluate environmental contamination after enhancement of infection prevention and control measures (IPC) during the COVID-19 pandemic. We also compared environmental contamination of low-and high-touch surfaces, patient hands and PPE of HCP, and the results were also linked to clinical data of sampling patients. Another study found only 1 out of 14 surgical masks worn by mild and severe COVID-19 patients tested positive for SARS-CoV-2 . Environmental contamination of the SARS-CoV-2 viral RNA could be found even in seroconverted patients in healthcare settings, and the contamination risk was higher in high-touch areas near severe/critical patients. cache = ./cache/cord-301079-n1nytr6k.txt txt = ./txt/cord-301079-n1nytr6k.txt === reduce.pl bib === id = cord-301281-yur5hs2h author = Zelek, Wioleta M. title = Complement Inhibition with the C5 Blocker LFG316 in Severe COVID-19 date = 2020-11-01 pages = extension = .txt mime = text/plain words = 1671 sentences = 87 flesch = 44 summary = We here report the contribution of complement activation and impact of complement blockade in severe COVID-19, defined as marked respiratory impairment requiring intensive care and ventilation support. Five patients were selected, based on high levels of TCC (above the mean 1 2 SD for controls; 7.14 mg/L) and either treatment failure (patients 1-3) or failure to improve (patients 4 and 5) where death was not considered imminent (clinical judgement), for inclusion in a compassionate use study of complement blockade using LFG316 (tesidolumab; Novartis Managed Access Program), a C5-blocking monoclonal antibody (mAb) that prevents generation of the proinflammatory effectors C5a and membrane attack complex (6) . We describe a preliminary evaluation of the potential benefit of C5 blockade in severe COVID-19; we show that the C5-blocking mAb LFG316 could be administered in critically ill mechanically ventilated patients with COVID-19; a single dose of LFG316 blocked C5 activity and complement activation for at least 4 days in all treated patients. cache = ./cache/cord-301281-yur5hs2h.txt txt = ./txt/cord-301281-yur5hs2h.txt === reduce.pl bib === id = cord-301391-5dvf1mi0 author = Islam, Md. Milon title = Breathing Aid Devices to Support Novel Coronavirus (COVID-19)Infected Patients date = 2020-08-19 pages = extension = .txt mime = text/plain words = 4402 sentences = 266 flesch = 53 summary = It is a matter of hope that the recent deployment of small-scale technologies like 3D printer, microcontroller, ventilator, Continuous Positive Airway Pressure (CPAP) are mostly used to resolve the problem associated with medical equipment's for breathing. We described the most recent developed breathing aid devices such as oxygen therapy devices, ventilator, and CPAP throughout the review. The review described breathing aid devices like oxygen therapy devices, ventilators, and CPAP devices. Breathing aid devices are used to support the patients who have acute respiration problem due to pneumonia associated diseases like COVID-19, asthma, and dry coughing. The key feature of this study is that without any respiration tubes, the proposed device can provide necessary ventilation to the patient's lungs with the blower unit. A lowcost, microcontroller controlled electro-mechanical device is developed in [61] for the respiratory support of COVID-19 infected patients. [66] proposed a multi-powered CPAP device for respiratory support for the patients having a breathing problem. cache = ./cache/cord-301391-5dvf1mi0.txt txt = ./txt/cord-301391-5dvf1mi0.txt === reduce.pl bib === id = cord-301342-ikvpkhfp author = Xue, Katherine S title = Parallel evolution of influenza across multiple spatiotemporal scales date = 2017-06-27 pages = extension = .txt mime = text/plain words = 6104 sentences = 301 flesch = 50 summary = Viral variants that arise in the global influenza population begin as de novo mutations in single infected hosts, but the evolutionary dynamics that transform within-host variation to global genetic diversity are poorly understood. Recent deep-sequencing studies of human clinical samples suggest that influenza accumulates relatively limited genetic diversity within hosts during most acute infections (Dinis et al., 2016; Poon et al., 2016; Sobel Leonard et al., 2016; Debbink et al., 2017) , in line with earlier studies in dogs and horses Hoelzer et al., 2010) . We sequenced the full viral genome to high coverage directly from patient nasal wash samples by using influenza-specific reverse transcription and PCR (Hoffmann et al., 2001) to enrich for viral genetic material (Figure 2-figure supplement 1). Strikingly, many of the HA mutations that arise in parallel in multiple patients in our study also reach a high global frequency, which may reflect concordant antigenic selection at the within-host and global scales. cache = ./cache/cord-301342-ikvpkhfp.txt txt = ./txt/cord-301342-ikvpkhfp.txt === reduce.pl bib === id = cord-300811-l4y7df2f author = Aggarwal, Gaurav title = Association of Cardiovascular Disease with Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis date = 2020-04-28 pages = extension = .txt mime = text/plain words = 2537 sentences = 147 flesch = 46 summary = We conducted a meta-analysis of recent studies that reported the association of CVD with worse prognosis and increased mortality in COVID-19 patients. Inclusion criteria were observational case-control or cohort studies on COVID-19 patients with a history of CVD included, which reported outcomes of COVID-19 infection severity, clearly outlined the definition of "severe disease" and with sample size >10. To this end, we carried out a pooled analysis of current studies and evaluate the association between underlying or previous history of CVD conditions and outcomes of infection severity in COVID-19 patients. Pooled analysis of these studies did not find a significant association between previous history of CVD and mortality in severe COVID-19 disease (OR=1.72; 95% CI: 0.97-3.06, I 2 =0%, Cochran's Q=1.56, p=0.46). A total of 3 (n= 566) studies reported data on mortality in all hospitalized patients COVID-19 disease and pre-existing history of CVD. cache = ./cache/cord-300811-l4y7df2f.txt txt = ./txt/cord-300811-l4y7df2f.txt === reduce.pl bib === id = cord-301146-no9pw4gn author = Lattenist, R. title = COVID-19 in Adult Patients with Hematological Disease: Analysis of Clinical Characteristics and Outcomes date = 2020-07-07 pages = extension = .txt mime = text/plain words = 867 sentences = 57 flesch = 52 summary = authors: Lattenist, R.; Yildiz, H.; De Greef, J.; Bailly, S.; Yombi, J.C. title: COVID-19 in Adult Patients with Hematological Disease: Analysis of Clinical Characteristics and Outcomes However, data on patients with COVID-19 and an underlying hematological disease as well as on specific risks factors in this particularly immunocompromised population are scarce [2] [3] [4] [5] . The association between lower hemoglobin level at presentation and a higher mortality rate was also found by Mehta et al. In our small cohort of patients, we found no association between the myeloid/lymphoid character of the underlying disease and COVID-19 fatality (data not shown) but, to mention, our series did not include any MPN or MDS except under the form of a progression to secondary acute myeloid leukemia. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study cache = ./cache/cord-301146-no9pw4gn.txt txt = ./txt/cord-301146-no9pw4gn.txt === reduce.pl bib === id = cord-301087-9vl5pqi7 author = Teh, Benjamin W. title = Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital date = 2014-12-10 pages = extension = .txt mime = text/plain words = 2634 sentences = 147 flesch = 41 summary = The epidemiology, risk factors and outcomes of viral respiratory tract infections (vRTI) are not well described in patients with multiple myeloma managed with novel agents, the current standard of care. Whilst the epidemiology, clinical outcomes and risk factors associated with viral RTI (vRTI) are well known in the haematopoietic stem cell transplant (HSCT) setting and supported by appropriate management guidelines, these characteristics have not been reported in myeloma patients managed with novel agents [5, 6] . Patients were identified retrospectively from chemotherapy drug dispensing and microbiology databases using the following criteria: a confirmed diagnosis of multiple myeloma, received active therapy with IMiD or PI and tested positive for respiratory viral (RV) infection by nucleic acid amplification testing (NAT) at Peter MacCallum Cancer Centre (PMCC) from January 2009 to December 2012. Clinical records of eligible patients were reviewed using a standardized tool to capture the following: patient demographics, myeloma therapy, seasonality of infection, radiological changes, clinical features and outcomes (length of stay (LOS)), requirement for intensive care (ICU) management and all-cause mortality at 30 days). cache = ./cache/cord-301087-9vl5pqi7.txt txt = ./txt/cord-301087-9vl5pqi7.txt === reduce.pl bib === id = cord-301592-n5ns3m34 author = Ivaska, Lauri title = Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection date = 2017-01-07 pages = extension = .txt mime = text/plain words = 4142 sentences = 249 flesch = 47 summary = We aimed to document the viral and bacterial aetiology of pharyngitis and to assess the pathogenic role of viruses by determining the myxovirus resistance protein A (MxA) in the blood as a marker of interferon response. We aimed to document the viral and bacterial aetiology of pharyngitis and to assess the pathogenic role of viruses by determining the myxovirus resistance protein A (MxA) in the blood as a marker of interferon response. Methods: In this prospective observational study, throat swabs and blood samples were collected from children (age 1e16 years) presenting to the emergency department with febrile pharyngitis. Methods: In this prospective observational study, throat swabs and blood samples were collected from children (age 1e16 years) presenting to the emergency department with febrile pharyngitis. 23e25 The aim of this study was to document the microbial causes of acute pharyngitis in children and adolescents in an outpatient setting and to evaluate the causative role of viruses by determining myxovirus resistance protein A (MxA) and other biomarker levels. cache = ./cache/cord-301592-n5ns3m34.txt txt = ./txt/cord-301592-n5ns3m34.txt === reduce.pl bib === id = cord-300963-1n1f8mf2 author = Gajendran, Mahesh title = Inflammatory bowel disease amid the COVID-19 pandemic: impact, management strategies, and lessons learned date = 2020-10-12 pages = extension = .txt mime = text/plain words = 6681 sentences = 350 flesch = 46 summary = Previous studies based on SARS-CoV-1 showed that the "cytokine storm" was strongly associated with viral sepsis, inflammation-induced lung injury, and acute respiratory distress syndrome (ARDS) [32, 34] . With regard to IBD-specific risk factors, it is speculated that patients on immunosuppressive agents, those with active IBD symptoms, malnutrition, and frequent visits to clinics or hospitals are at greater risk of acquiring SARS-CoV-2 infection [50] . The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) maintains a registry for reporting COVID-19 in IBD patients called SECURE-IBD registry. Hence, all the societies have recommended that patients continue their IBD medications to sustain remission, because the risk of disease flare-up outweighs the chance of contracting SARS-CoV-2 infection. The management strategy will depend on multiple factors, such as the patient's age, the severity of the COVID-19 infection, the clinical status of the IBD, and the presence of other comorbid conditions. cache = ./cache/cord-300963-1n1f8mf2.txt txt = ./txt/cord-300963-1n1f8mf2.txt === reduce.pl bib === id = cord-301832-6czrdmzb author = Leber, Danielle title = PC-FACS September 1, 2020 date = 2020-09-06 pages = extension = .txt mime = text/plain words = 2363 sentences = 156 flesch = 49 summary = This single-site prospective longitudinal study (1998) (1999) (2000) (2001) (2002) (2003) (2004) (2005) (2006) (2007) (2008) (2009) (2010) (2011) (2012) (2013) (2014) (2015) (2016) among nondisabled community-living persons age ≥70 years evaluated risk factors and intervening illnesses and injuries (ie, events) associated with reduced recovery after episodes of progressive and catastrophic SD. To access this article, link to PubMed. Background: Clinical effectiveness is defined as the application of the best knowledge (from research, clinical experience, and patient preferences), to achieve optimum processes and care outcomes. This study evaluated care effectiveness in an Ireland SPCU, including an analysis of the temporal relationship among unit admission, patients' phase of illness, and different aspects of patient and family distress. To access this article, link to PubMed. Background: Studies evaluating the effects of pre-existing mental health disorders (MHDs) on patients diagnosed with lung cancer universally find mental illness to be associated with increased mortality. cache = ./cache/cord-301832-6czrdmzb.txt txt = ./txt/cord-301832-6czrdmzb.txt === reduce.pl bib === id = cord-301811-ykpiorgo author = Tanaka, Takuma title = Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing date = 2020-10-28 pages = extension = .txt mime = text/plain words = 5530 sentences = 296 flesch = 55 summary = title: Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing We estimated the numbers of undiagnosed symptomatic patients and the lower bound of the number of total infected individuals per diagnosed patient before and after the declaration of the state of emergency in Hokkaido, Japan. The present analysis uses the distributions of the cluster size and patients' time from onset to diagnosis, which are released by the health officials, to estimate the model parameters. At the same time, the nodes in the connected component containing the diagnosed node are also removed from the network, which corresponds to the contact tracing of the infected individuals (Fig 2, gray open circles) . In this paper, we have formulated a model to describe the spreading of infection and the quarantine of infected individuals, and estimated the number of undiagnosed symptomatic and asymptomatic COVID-19 patients in Hokkaido. cache = ./cache/cord-301811-ykpiorgo.txt txt = ./txt/cord-301811-ykpiorgo.txt === reduce.pl bib === id = cord-301805-sb0ij8k7 author = Fuentes, Blanca title = Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study date = 2020-11-04 pages = extension = .txt mime = text/plain words = 3834 sentences = 235 flesch = 44 summary = METHODS: This translational study consists of two studies conducted in parallel: The first study is an observational, multicenter, prospective clinical study in which 340 patients with acute IS will be subcutaneously implanted a sensor to continuously monitor blood glucose levels for 96 h. DISCUSSION: The GLIAS-III study will be the first translational approach analyzing the prognostic influence of GV, evaluated by the use of subcutaneous glucose monitors, in acute stroke. We hypothesized that GV, assessable by means of continuous subcutaneous monitoring devices, could act as a powerful prognostic predictor of mortality, possibly higher than assessment of mean or maximum blood glucose levels and that the different treatment regimens used in routine clinical practice could modify glycemic variability. No laboratory data other than HbA1c will be collected for Discussion: The GLIAS-III study will be the first translational approach analyzing the prognostic influence of GV, evaluated by the use of subcutaneous glucose monitors, in acute stroke. cache = ./cache/cord-301805-sb0ij8k7.txt txt = ./txt/cord-301805-sb0ij8k7.txt === reduce.pl bib === id = cord-301340-lhh04pum author = Jamieson, Frances B. title = Human Torovirus: A New Nosocomial Gastrointestinal Pathogen date = 1998-11-17 pages = extension = .txt mime = text/plain words = 3401 sentences = 184 flesch = 39 summary = Torovirus-like particles purified from stool specimens were further shown to be toroviruses on the basis of their morphology, immunospecific interactions with Breda virus antiserum, ability to elicit an immune response following infection, and the high degree of homology of the 3 end of their genome with that of the Berne and Breda viruses [19] . At a different time from that of study 1, patients whose stool specimens were positive for torovirus, rotavirus, or astrovirus by electron microscopy were enrolled in study 2. In torovirus-positive patients, stool specimens were examined daily by electron microscopy during the hospitalization and at follow-up. Nine additional torovirus-positive patients developed bloody diarrhea within 2-15 days after study enrollment and had no other pathogen in the stool sample. Stool specimens collected on a follow-up visit 2-6 months after study enrollment from 168 patients infected with torovirus showed that 14 were shedding the virus. cache = ./cache/cord-301340-lhh04pum.txt txt = ./txt/cord-301340-lhh04pum.txt find: cannot fork: Resource temporarily unavailable ===== Reducing email addresses parallel: Warning: Only enough available processes to run 58 jobs in parallel. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf parallel: Warning: or /proc/sys/kernel/pid_max may help. cord-002240-38aabxh1 cord-003798-nki2sasr cord-002145-yq7iwp42 cord-001221-due9tloa cord-004646-zhessjqh cord-000843-e1bn79ui cord-005646-xhx9pzhj cord-006523-zxn4oqly cord-006343-c0amee70 cord-000977-ka4261wc cord-008596-zhk82cor cord-009891-gqrhbhbn cord-013116-n7auvqh3 cord-014540-27hnlu5v cord-014538-6a2pviol cord-014687-0am4l5ms cord-014794-yppi30a0 cord-023239-06a03o14 cord-025157-7b3v5yct cord-027805-p0bhju1s cord-021206-4zyqqgs0 cord-029332-yn603pvb cord-030962-2xem8inu cord-035030-ig4nwtmi cord-035067-ic843wr9 cord-035090-gnfeyddv cord-252539-kx8ew3ap cord-252085-8dq3gdo8 cord-255746-ir73lpi8 cord-257781-ybpliz32 cord-257839-kfzc4pwq cord-258888-amimzjee cord-259767-x9s8qprc cord-259073-dixskemz cord-264889-1vsvcza2 cord-264779-71s7e18i cord-266744-31p212aq cord-268531-igjeai8c cord-269289-6uog10j4 cord-270245-zziwb2jy cord-273426-55vu6b3u cord-276359-syr9av09 cord-276405-yfvu83r9 cord-278993-w5aa0elj cord-279570-lgbqpfh5 cord-281733-bsq0ewac cord-282783-ps5jyjkl cord-284298-tcied4l5 cord-284545-vn60yd46 cord-285291-pep4opiq cord-284944-hcgfe9wv cord-286237-x6dr6rsh cord-287376-wxldnlih cord-289054-fh95b5n4 cord-291024-9g4om4sf cord-294079-px9c20il cord-295216-eff02z0i cord-296182-hhswage4 cord-300038-1fjb6b8e cord-300963-1n1f8mf2 cord-304457-8g36h1bz cord-309360-cpis1l4u cord-309728-7vfotgrr cord-312918-iof45k1r cord-309517-yh4d414y cord-312033-iarl77n0 cord-313349-ikjivfce cord-316845-k9zvsfvj cord-317811-mxsujb5u cord-319742-ypkt01rn cord-321594-x5wv9p7n cord-321149-hffj7s4o cord-322534-eikz07zz cord-323225-ou7pppum cord-328384-jzfr2t3p cord-327836-6o66a4i5 cord-328039-xt17gvcp cord-330573-rr2r8245 cord-334367-w96iqo6q cord-335095-epsi5qq7 cord-335975-m6lkrehi cord-336000-v88bq4bx cord-337088-xxyhmn1t cord-336390-ptnpgh3j cord-337520-qp0ga6q8 cord-337906-qis8h3r3 cord-337431-3rrvm787 cord-338182-cetv78ba cord-341202-1pg7rq2d cord-340880-2qop8tcp cord-342068-zhk3wmou cord-343452-4m0ub9iv cord-345028-56hg62be cord-346345-jc9bq0zu cord-348578-chfb4i15 cord-349396-a6zyioc1 cord-349678-79zlgjqi cord-352889-fl61z3w3 cord-353200-5csewb1k cord-355038-o2hr5mox cord-356371-w9ejgzvu Creating transaction Updating adr table ===== Reducing keywords cord-000001-ug7v899j cord-001313-f72hl6du cord-000831-zwfxnd7r cord-000308-cxr1ul7q cord-000229-9fr0m92p cord-000716-fhm8abxp cord-002782-mena480g cord-002977-o0dvwzxk cord-000284-00rk8fb5 cord-003533-8m0vyxq8 cord-000522-d498qj2b cord-002240-38aabxh1 cord-002514-pp06m5xk cord-004379-91a7sgir cord-001421-6t5puo6p cord-002294-qa8e90qv cord-000457-e50a0suk cord-001322-7xmxcm35 cord-004986-en7taikk cord-001617-ff3j7i7i cord-003828-bhfghcby cord-003404-eqgc8v7y cord-003520-f3jz59pt cord-001661-dj9bxhwb cord-003701-i70ztypg cord-004310-hl7fa4af cord-002956-e5ihpe4i cord-004147-9bcq3jnm cord-004342-9uok77wb cord-001879-bn7h0kcw cord-004314-gtwtakpr cord-002774-tpqsjjet cord-004404-s6udpwxq cord-002757-upwe0cpj cord-004096-obrq7q57 cord-003291-zuqx6ksy cord-003798-nki2sasr cord-001154-7k59ogn0 cord-000161-hxjxczyr cord-001078-5m29nugu cord-001493-3yu2di1g cord-003219-iryb3v0z cord-000904-g6ffaer1 cord-000891-5r2in1gw cord-004636-t6qldq3s cord-004450-daxz9yhp cord-000268-480d3yfv cord-002145-yq7iwp42 cord-005482-v5iayczy cord-003686-1pfk4qve cord-003198-1kw5v6rm cord-004532-flo9139j cord-001293-dfaxj3bv cord-005425-0hxow3sj cord-005496-cnwg4dnn cord-004646-zhessjqh cord-003011-vclnb0eh cord-003446-yp5d29fk cord-001536-ta1i0ata cord-002853-vj8t28hn cord-000843-e1bn79ui cord-003832-q1422ydi cord-003376-2qi4aibx cord-004464-nml9kqiu cord-004263-m1ujhhsc cord-002626-jzwwses4 cord-004186-m817oudw cord-002724-gtv9syzi cord-004643-uu4uipfy cord-003615-vpzzsdld cord-004339-7nwpic3d cord-005420-60ie0pfd cord-004515-x22q1f21 cord-004949-icsey27p cord-001221-due9tloa cord-005503-hm8tvkt3 cord-003532-lcgeingz cord-005452-ouookpd8 cord-005606-c8c2rfzi cord-005569-9d51l6bn cord-005147-mvoq9vln cord-005481-00rezmqj cord-005480-yg7salqt cord-005587-8iwsvku9 cord-005487-vac061r8 cord-005646-xhx9pzhj cord-004894-75w35fkd cord-004675-n8mlxe7p cord-005478-5iu38pr6 cord-005697-l1zmrq4p cord-006179-7uv4yfv2 cord-005819-fp5khzd5 cord-005105-twsy61oq cord-005705-j765ruj1 cord-006181-fkh2fzbr cord-005861-3k8h3euj cord-006302-pnnkfid0 cord-005692-n4vxazst cord-006544-yr4u61qv cord-005992-mu917isy cord-005717-x7gsqlwp cord-006518-al94gxjw cord-006545-c12m75gq cord-005795-sgi54hq8 cord-006841-3u56erru cord-006236-2gpwf4z2 cord-006679-nhbofufv cord-005808-w0763esk cord-006750-cg2i2bae cord-006332-ikh45wuy cord-006394-ucthbqvt cord-005750-54hul2lw cord-006621-0fxpn7qf cord-006523-zxn4oqly cord-005497-w81ysjf9 cord-006343-c0amee70 cord-006391-esnsa4u5 cord-006000-ekwpkzqv cord-005953-5z89yeb6 cord-006563-qmigctkp cord-006344-de4dhv4b cord-006226-fn7zlutj cord-005816-i54q5gsu cord-006701-q8qh1kas cord-000083-3p81yr4n cord-006426-baf2d47y cord-005777-6rvfsx4p cord-006363-xov4xwpa cord-006714-q7wy76e2 cord-007575-5ekgabx5 cord-006508-rje9bnph cord-006856-b1w25ob5 cord-006464-s8rjoyse cord-006768-r2pa9qw0 cord-007444-c9vu8ako cord-006517-845w9r6l cord-006444-eq56zhtd cord-007567-vst954ef cord-006862-5va1yyit cord-006595-brpngt14 cord-007321-7gi6xrci cord-007564-ljqrxjvv cord-007009-4wbvdg1r cord-006869-g2q1gpp0 cord-006864-t5qsjyfi cord-006460-3ayc0hne cord-006828-i88on326 cord-000718-7whai7nr cord-005881-oswgjaxz cord-006702-ekf6mja9 cord-007563-33jxxp1b cord-006924-1i3kf01j cord-006882-t9w1cdr4 cord-006975-u5ecibta cord-007818-jfp9uumb cord-007786-cu831tl7 cord-006888-qfnukav4 cord-008672-luoxomif cord-007833-wkv808ix cord-007580-qwh8ei60 cord-000977-ka4261wc cord-007696-83v9yfa6 cord-007788-09t52zix cord-006876-v2m5l5wz cord-007865-1oyl6clq cord-006880-9dgmdtj8 cord-007798-9ht7cqhu cord-006182-kck5e1ry cord-008596-zhk82cor cord-005727-li8pwigg cord-009417-458rrhcm cord-009278-98ebmd33 cord-009285-1ddfywfa cord-008695-y7il3hyb cord-009360-rgwe2pkx cord-009891-gqrhbhbn cord-009512-o4y9s8zf cord-010116-hfzs16jh cord-006860-a3b8hyyr cord-007577-f1jzbtjj cord-009575-bd67ph64 cord-009322-7l7slziv cord-009507-l74c9x0n cord-010078-8lkkez3n cord-009571-mygj2nd4 cord-010487-wncgecld cord-009982-zgbu46fo cord-010856-3g0123lk cord-009667-8r8j0h08 cord-010658-67k8pthy cord-010261-sy7esszi cord-010999-u2guhh3h cord-009697-dq4y89ab cord-011138-y9v5ivzg cord-010844-y26y5myb cord-010477-g754gjvh cord-009713-sxd4t2tz cord-006466-e1phpqes cord-006854-o2e5na78 cord-011159-k2kca8zl cord-006870-f5w6fw6q cord-009788-bc6sc2rc cord-010036-6czkzek0 cord-010929-d598h08w cord-006849-vgjz74ts cord-010141-955r29sd cord-010416-u0yo0lk6 cord-010461-un9pls28 cord-010564-7c9h16bi cord-010786-w3kjc6so cord-009967-fyqc5bat cord-010398-5wot7tix cord-010075-72jodunj cord-010460-pczs9alv cord-009664-kb9fnbgy cord-011093-d9dbvbcy cord-010921-yzv43e8l cord-010566-tciwtxud cord-011533-im78xwl8 cord-011360-1n998win cord-011413-yv4x8viu cord-010027-r0tl01kq cord-011296-nutl2ovk cord-011181-9nvwk04v cord-011284-u4qmvz3c cord-011255-9q2frk71 cord-011725-t1jl4cy1 cord-011712-fyrbe8tw cord-011349-bykvn367 cord-011483-zc6ve6le cord-011297-4um9w2dx cord-011975-8vl45xb7 cord-010088-s9tfvtao cord-011512-gw2sk90q cord-012025-faj682bp cord-011649-3dlsy8fl cord-011221-rhyxp4v5 cord-012117-c693oefo cord-011188-59hn9wsv cord-012115-hpsxi9ay cord-011793-hlktpla4 cord-011062-ukz4hnmy cord-010933-xuztu95a cord-011103-sstpidvk cord-012459-tge08va0 cord-011327-zsoc4wec cord-011302-pfepyvaw cord-012665-fflye8a3 cord-012778-yr8zuvw9 cord-011875-ga0dzj3v cord-013035-7sfj0czv cord-013149-y0dbhtef cord-012469-6cvu5umd cord-012902-efprpk72 cord-012037-9kmul7he cord-013003-gxd29jxf cord-011836-zib8wkm2 cord-013116-n7auvqh3 cord-013139-b32xg7y7 cord-013105-tmhce7p5 cord-013370-gktnz644 cord-012934-c6pbr64i cord-012518-ncrdwtdg cord-013148-qbxbndsl cord-014833-ax09x6gk cord-012560-p5s0p7fd cord-013589-3l8kar3k cord-007890-bie1veti cord-013457-rqon1adg cord-014540-27hnlu5v cord-013380-1jwzbgwb cord-014538-6a2pviol cord-014712-5u4e00q6 cord-015090-n6f4xupw cord-013558-0sa63lp3 cord-014670-e31g8lns cord-014933-3jezc081 cord-015082-l629n8is cord-015335-l0kjxhd1 cord-014965-efmozngq cord-015389-vwgai4k9 cord-015162-6be21d59 cord-010980-sizuef1v cord-015930-18qznqp0 cord-014980-cz1gx9oj cord-014533-6qfecv5h cord-014987-nycbjqn6 cord-015365-iqdi99pd cord-016280-d47e3art cord-015334-8p124rwp cord-015569-vy49r1zd cord-015348-qt0worsl cord-016237-sk1wzghx cord-005814-ak5pq312 cord-016248-dxk0i6t7 cord-015946-biu5zxd1 cord-016211-8j8n9enn cord-016110-mlwe7fzz cord-016301-vqmqnipq cord-015884-mtpbzgr9 cord-016135-44pgjah8 cord-015922-5wwy0m2k cord-016208-u12ngkpc cord-015126-cyhcbk1j cord-014976-546zaoxn cord-015640-zdwmxaz3 cord-014687-0am4l5ms cord-016498-j72vrvqf cord-016601-gp259urb cord-015372-76xvzvdg cord-016127-tbot0fc9 cord-016105-jkaxemmb cord-016177-fz48wydz cord-016235-2lhrkmrv cord-016372-opojt70e cord-015370-4jfgsic7 cord-016460-39yniw0t cord-016413-lvb79oxo cord-016300-vw11c2wt cord-016308-qzkcwrit cord-016871-1mlamf20 cord-015024-2xzc0uc5 cord-015368-a0qz4tb9 cord-016521-ouwwkxox cord-014996-p6q0f37c cord-016814-tf17dpo5 cord-017105-mljywm9p cord-017012-yl0vanuh cord-016572-6fu5s89c cord-016559-tqd7m2i1 cord-016973-s32jp0ej cord-017252-88b3preq cord-016757-3d320c0a cord-017227-66dx2dkv cord-016476-78r0rsio cord-017040-4zajnrsf cord-016478-gpl0zbvd cord-016960-xhzvp35g cord-014464-m5n250r2 cord-016982-qt25tp6t cord-017217-zjab7o2o cord-017142-vx3rgs4r cord-015369-72cjogxz cord-009567-osstpum6 cord-015352-2d02eq3y cord-017350-rwqaw5ii cord-017309-pt27efu1 cord-017302-xez0zso3 cord-017016-twwa9djm cord-015306-us58wwmp cord-017324-l3d3t4wh cord-017337-vq3edhxn cord-017392-ja9b5vy9 cord-017184-1ewi3dka cord-017489-ftz9190a cord-017374-clctlm5l cord-017531-fm8gl5b3 cord-017420-tjwxec77 cord-017534-0ai8chbu cord-017518-u2gsa4lg cord-017461-xw02c7u5 cord-017772-zpf1xjqi cord-017393-kx8kmdej cord-017569-fv88n70v cord-017715-99ri6x0y cord-017516-qbksb83c cord-017581-6lubp7io cord-017617-13m7pmvq cord-017883-6a4fkd5v cord-017784-4r3fpmlb cord-017897-mbwm0ytg cord-017815-0t7jvvz5 cord-017862-9fkjjmvf cord-018005-53cl75gk cord-018182-lleti89n cord-017946-fa4ehlb0 cord-018209-v2crgj5w cord-017799-2nvrakbs cord-018110-mcw4v13c cord-018106-5giapmcf cord-017786-kfl6xt31 cord-018318-vzzrsqsn cord-014794-yppi30a0 cord-018363-qr1pk78u cord-018243-hyvu9nuq cord-018303-dvuwhpyq cord-018408-ttae193b cord-018414-6ffhm895 cord-018545-fk17n2bx cord-018590-rkp89dqo cord-018412-kv3vxmcw cord-018225-dozmy3lb cord-018447-z4jyjczy cord-018454-sy21cpff cord-018430-u3k8pds6 cord-018620-3kqx8arn cord-018623-of9vx7og cord-018595-x3tleomb cord-018801-amet0wx4 cord-018601-mk66097y cord-018638-4pyjhpbk cord-018780-zeok60hn cord-018714-i291z2ju cord-018834-4ligp4ak cord-018809-3nrvm4jt cord-018907-c84t1bo5 cord-019046-q6uv2ayi cord-019010-9xgwjvsv cord-019027-6chba2ru cord-015021-pol2qm74 cord-019043-cqmqwl3i cord-019968-o5bdb37q cord-019064-e5z92vg8 cord-021721-80pp1ra4 cord-021713-e0hzcag6 cord-018840-ts2g1ux7 cord-019964-9leljj8j cord-021742-sdz6d1r5 cord-022050-h24f0fpd cord-021917-z9wpjr0d cord-015359-gf32a6f1 cord-021701-yan5q2r7 cord-021816-gk8rwyq4 cord-019063-mcxbl8mv cord-021075-8hba6au3 cord-022292-msz4au4b cord-022119-bzd9e1q6 cord-021571-7kbq0v9w cord-009997-oecpqf1j cord-022103-4zk8i6qb cord-021905-fjcks7w4 cord-020342-u8jzmloq cord-022646-f7qs1obg cord-022521-r72jtoso cord-022173-kb6mez61 cord-023169-obupqcua cord-022658-mq91h15t cord-022216-k4pi30sd cord-022594-fx044gcd cord-022527-a0x6lws3 cord-023288-sqr33y72 cord-022659-chwk2bs4 cord-019490-m1cuuehi cord-023168-cd7adns8 cord-023622-tul7bonh cord-023303-fxus38mp cord-023302-p9pxz44a cord-023033-tgt69ir6 cord-023311-7wqdlha4 cord-023483-owgs4syo cord-023669-3ataw6gy cord-023186-gqltd6u0 cord-024233-hrzpxdh0 cord-023216-avn8f2w3 cord-023017-k6edtg58 cord-023308-af5nihyi cord-023729-dipjubn7 cord-023873-fidpskcs cord-023314-rwjxk8v4 cord-023305-5lb9kho6 cord-023343-y17z9w2x cord-023306-3gdfo6vd cord-023298-ysur3sjq cord-024130-kgzegwon cord-023331-jrvmgnu3 cord-024614-6bu3zo01 cord-023333-b7w9zrl6 cord-024956-oht0v33s cord-022653-qa1uph35 cord-024120-3eemj37r cord-024073-243addff cord-024893-pd67o7l8 cord-023509-tvqpv6fp cord-024795-xa7ke70d cord-023833-xpfibjh2 cord-025157-7b3v5yct cord-023239-06a03o14 cord-024189-t7mbsr25 cord-025749-mip9mkef cord-019347-tj3ye1mx cord-025666-u8w4sk07 cord-025172-qg3jxgch cord-027551-a92lv4sh cord-025990-nj4ah2yz cord-024833-e6vcf4un cord-027805-p0bhju1s cord-025170-dtbm4ue1 cord-026846-3u3x52f8 cord-025176-f0frlpwh cord-026879-gwzrdeb1 cord-027266-jdti1pwa cord-023913-pnjhi8cu cord-025164-hqj22yxe cord-026392-cvb44v5v cord-026653-094bk0t0 cord-026991-75sbxnsc cord-026868-z9gozm2w cord-026025-xqj877en cord-028328-5lews3uw cord-027678-k64whepc cord-028557-68jypaaw cord-027860-s97hdhh6 cord-027259-f4sgobcz cord-028260-mja2jrgm cord-028709-r1inj3ra cord-028285-n4dommet cord-028907-m9psxg1f cord-027677-fc410vto cord-028982-kkzpqbry cord-028379-ghudhac6 cord-022633-fr55uod6 cord-028590-rw0okd0p cord-029183-3aotgq6m cord-015354-yknwveyz cord-029466-9sy6icrm parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. cord-029211-6o7qn2y2 cord-029606-2z1tw4xo cord-029626-j6b59y7a cord-029112-u507i0t0 cord-029612-cts1al9z cord-029770-72ncfyc5 cord-029609-zh2ah34g cord-021206-4zyqqgs0 cord-029615-x498xj3m cord-029848-dj5xqlz1 cord-022650-phsr10jp cord-029547-9ei1ram3 cord-029859-fhm0d9t9 cord-023592-w96h4rir cord-030256-muah207b cord-022501-9wnmdvg5 cord-029991-0sy417j0 cord-010092-uftc8inx cord-030254-eevqclsy cord-031130-xvkyt3l3 cord-029332-yn603pvb cord-028721-x6f26ahr cord-026031-hnf5vayd cord-031544-clzt6kyg cord-030927-wo8r8zny cord-029884-zl0uqmfi cord-021087-n4epxwn9 cord-030370-89n13hml cord-030918-0w327dgj cord-029150-e242o2ml cord-030502-mvlib8ol cord-030531-4uucx9ss cord-031129-wqkdug42 parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. cord-030149-hkpjnqm9 cord-005460-ezrn8cva cord-023354-f2ciho6o cord-023346-8sqbqjm1 cord-030369-4dn02a35 cord-030897-c88tjrai cord-032588-8bfl2qy1 cord-024651-578c9ut5 cord-032335-6c9gt7t9 cord-023049-fio7cjj5 cord-033279-bcf9568a cord-031710-1xl2isee cord-030216-l38i06v2 parallel: Warning: No more processes: Decreasing number of running jobs to 93. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. cord-030380-okue1kso cord-031558-8wysernx cord-031256-4mxt501d cord-030962-2xem8inu cord-034157-uif9xtvl cord-032544-2yrqjw1o cord-030361-0tepkjdl cord-023157-0lqlx2rv cord-023364-ut56gczm cord-032928-m0awip9y cord-033247-2cbslnb7 cord-033965-c1i7dnnt cord-032392-ex3s8evv cord-033135-cxsmxk3b cord-031734-5wnvuk2n cord-031821-rywdkqcd cord-031191-63xtga7h cord-033778-u2r0neyc parallel: Warning: No more processes: Decreasing number of running jobs to 92. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. cord-022888-dnsdg04n cord-034257-kl2ccmz5 cord-033574-4y53ryoa cord-034036-1wigu3i3 cord-031497-pp0p3en6 cord-015324-y44sfr0c cord-034286-m1c98nv7 cord-032930-ohsh46l2 cord-033327-yi1tvsh4 cord-034185-e0am7pa6 cord-032183-yqqqe325 cord-033019-4eo037jp cord-034435-yp0gfl47 cord-034303-kcu9guxa cord-034690-x8lkngra cord-034371-j3xxmkjd cord-032244-s7t5u9lf cord-034340-3ksfpaf7 cord-034746-uxhpufnv cord-103686-er8llst4 cord-034898-zjfhpum2 cord-035024-kx9jfssi cord-035067-ic843wr9 cord-032181-gmcugd8h cord-048489-ajafw966 cord-035030-ig4nwtmi cord-035026-2qcsfd87 cord-034578-i9rdubix cord-035070-drt6esrk cord-035316-l4qbiuuu cord-104055-47ren7ie cord-035090-gnfeyddv cord-102199-mc6zruyx cord-103214-3lz33pj3 cord-102276-0a8hup5y cord-048343-nzk8m912 cord-104180-f3hoz9bu cord-035182-ax6v3ak5 cord-184194-zdxebonv cord-035315-j5mknuv5 cord-214006-0w6bqrox cord-103807-x4hrwhkz cord-104467-elwfz1gk cord-104507-xx7t26rl cord-035396-lg7m9xzs cord-148109-ql1tthyr cord-217201-lvefk7qx cord-244388-dxrrpxl7 cord-158252-l43ztxsl cord-204125-fvd6d44c cord-216974-0al3vdh1 cord-103659-wpwfqhp2 cord-252159-6t35bxwv cord-252617-rqm0p19e cord-138439-wvynetna cord-252829-gn56tsz3 cord-252473-i4pmux28 cord-252374-obl6pfpf cord-252013-ehyuflg3 cord-251957-luw8m3eq cord-252368-njlo6g78 cord-252506-8u9oiqoc cord-252531-i3b647wv cord-252279-0gozdv43 cord-252288-klkoerfn cord-252539-kx8ew3ap cord-252284-cgdcsazr cord-252101-77lnyjan cord-252060-cotsu82v cord-252687-7084pfqm parallel: Warning: No more processes: Decreasing number of running jobs to 91. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. cord-225218-x32a4sp3 cord-252452-wwkw1uyi cord-104404-ytszpa4c cord-253168-b095rq5i cord-252085-8dq3gdo8 cord-252243-ua2w6xki cord-253148-3t4o27xp cord-252699-0xw9xvox cord-253456-u9num2o9 cord-252751-prock3co cord-252890-of29g89s cord-254148-wc762p6v cord-253886-4b3i30hi cord-252981-hywvmdjb cord-254269-x8vpnhd2 cord-253638-5f9ofdsc cord-253256-909chgl0 cord-253129-v5lck9l7 cord-253417-ihi67m1u cord-253375-m3qjj7r4 cord-253077-61fmul8c cord-254072-evgw0as5 cord-253962-ug7yflxh cord-252775-faxiem2w cord-253862-jl1zhg13 cord-253704-y0t30xw3 cord-253189-uba6dy08 cord-253295-82ydczid cord-254446-yxqbe1dj cord-253402-6sgeraws cord-254428-n0uwy77g cord-253746-15w4gquq cord-253970-sbj869yy cord-253730-cdkzvfib cord-254990-nrzwn6oz cord-254478-scc9wee0 cord-254040-s3k51rkk cord-005453-4057qib7 cord-255233-rvgj6pvk cord-255197-79yfslu1 cord-254025-j1l0mder cord-254993-bndl93qr cord-254357-5s84kimn cord-255300-btyth32l cord-255256-8uckmya4 cord-254419-qw83atrx cord-254852-qr5gdmbc cord-255267-o8k5ep9y cord-255490-gyq6cpc9 cord-255240-ltatgq3e cord-254382-xy8se56o cord-255393-aknebauo cord-254377-j8e8gb0l cord-254777-h8hw4m9f cord-254595-by2j7byz cord-255746-ir73lpi8 cord-023211-kt5gt26t cord-255519-tcobane8 cord-256109-dkp0fwe3 cord-255831-nrc35tug cord-256011-0cr4ejxu cord-256262-lwc4ghj2 cord-254494-wbfgrez1 cord-256051-87alqfkd cord-255037-i9guxtix cord-255435-mr239gai cord-256459-6h358si5 cord-255460-r5p5helx cord-255807-7goz1agp cord-010119-t1x9gknd cord-256030-5xzuilc1 cord-256117-t9v1hng5 cord-256290-pyrmtps3 cord-256888-tdx12ccj cord-257035-ob1xncbs cord-256618-tt3p0tki cord-256508-ce59ovan cord-255805-wlr8nod3 cord-256535-fz5p2u6p cord-255652-3n2dxljj cord-255905-ti9b1etu cord-257274-fzyamd7v cord-256556-1zea3wa1 cord-257206-av2k44ig cord-256849-8w2avwo2 cord-256639-4e0irb6d cord-257504-tqzvdssb cord-256893-3sh87h2x cord-257147-i48qljv6 cord-257276-h5542vqg cord-256856-jw1d6uig cord-257884-5exwwxin cord-257717-fbfe5vt4 cord-257600-0plhquk9 cord-258027-f3rr5el1 cord-256864-v3mxcwru cord-257344-d13at1y5 cord-258113-mnou31j3 cord-256688-yy7abob9 cord-257051-ntnfu5ns cord-258067-par61wwh cord-258293-7q9zj8c2 cord-257408-ejhhk1iu cord-257467-b8o5ghvi cord-258278-25rhf91v cord-257781-ybpliz32 cord-258548-1u7v1nlr cord-257839-kfzc4pwq cord-258416-1jrbu8ox cord-256634-gg8hptfg cord-257732-3xuy6tbn cord-257336-rpx71ww5 cord-257309-sazs5wgh cord-257433-qgkwylmk cord-258093-6fn8ei9f cord-257729-s0vo7dlk cord-258117-5gpo8smn cord-258708-da6x5rxa cord-258727-mhg56j20 cord-258583-5qdthy0j cord-258576-ywbyflas cord-258692-dch1utis cord-258888-amimzjee cord-257696-ybu772zw cord-258758-sz8chn5e cord-258402-9s57thvn cord-258315-yt1ytasw cord-259801-xuvcrvo2 cord-259229-e8m8m4ut cord-258133-zsweppku cord-258128-qtmjgrml cord-259448-deya8dwn cord-259699-48jg7ci7 cord-258930-60yn4hg7 cord-258498-0mvxwo3w cord-258916-jbdz1pk0 cord-259767-x9s8qprc cord-259984-csdf1a69 cord-260105-ckh8jp9e cord-260456-kjmab3og cord-260503-yq4dtf8n cord-259969-q65k590s cord-259747-sl9q63oc cord-259073-dixskemz cord-259907-yqmi0cqy cord-260525-bohv78hi cord-260215-gsnjlhjd cord-259585-mjtxiu0t cord-259329-8pta6o6a cord-260037-ys62jrgw cord-260083-c1r9zn43 cord-260180-kojb8efv cord-259411-434acu0h cord-260630-vvpzp73r cord-260232-98gtlad6 cord-259204-27t269pd cord-260700-u12aa739 cord-260274-c3586tp6 cord-260679-tm1s6wvj cord-260605-smkr7b15 cord-031907-ilhr3iu5 cord-260762-1kuj5dzz cord-261006-2xh3f07i cord-260980-tyf3fuz9 cord-260224-1aeqe7fh cord-260981-647wfa8z cord-261062-9zhe3ejy cord-260871-dtn5t8ka cord-259848-0thzmh7k cord-261410-kb91eagd cord-261151-27ocvgnw cord-261383-izd1vn6f cord-260854-v7wgb6mr cord-261470-sqxdwu6j cord-260119-pgu2crhs cord-261485-0ke5nqy0 cord-261025-y49su5uc cord-261801-va2e029z cord-261311-j6bmgmhz cord-261246-m40kwgcg cord-260857-oxxle915 cord-261380-xms5su6w cord-261980-bm0benu2 cord-261921-c97ygxq2 cord-261670-rd9uq6tc cord-261240-osbk041e cord-261736-jlwctmxw cord-261856-i1e0uj0s cord-022940-atbjwpo5 cord-262412-bs7quwov cord-261455-uejtwgar cord-262068-9ixq8hwb cord-262236-1lilrqts cord-262454-bccrvapy cord-262339-e2ayh108 cord-262626-yk4e737w cord-262150-j72jbohi cord-261941-xf1k5uj1 cord-262824-xgf5v1ok cord-262796-syu4wbpi cord-262708-hctuxrw9 cord-262780-ilu5oskk cord-262729-qcijsyo6 cord-262954-saqo900k cord-262467-epqqd8n8 cord-262518-a2ql8hib cord-262551-hxhlhb5m cord-262928-l2bqcd0l cord-262973-mydn7ver cord-262784-r9gq2oan cord-263061-ocplcdiv cord-262998-cugd2t1l cord-262987-7h91n9ro cord-263055-4f25h9l4 cord-263292-qjfe2t9v cord-263285-89zqgqx1 cord-263214-h6lkvlj3 cord-263064-n4c0m5hn cord-263716-ywsm11aw cord-262878-ygvbqmxd cord-263046-3aerbonz cord-263031-cco2vh0f cord-263599-cqol8zf2 cord-263691-ovsi38bx cord-263191-osa3ylkl cord-263530-t9ryky6f cord-263883-7ba0huwy cord-263241-qzerj9bs cord-264327-uzlavmhx cord-263066-umvojci8 cord-263882-s5oxr6es cord-264073-yhztrscf cord-264180-0vd3tr9j cord-263793-bmadusm6 cord-264122-n64tm6qr cord-263908-4ti8l2ea cord-264368-p2fwuh0i cord-264647-9r443j3l cord-264673-67zopf7s cord-264751-2l3cqhe2 cord-264295-7ojvhwb0 cord-264449-p3tgjuj4 cord-263628-ac9gld5l cord-262766-ndn6iwre cord-264504-nnvof29x cord-264889-1vsvcza2 cord-264829-ynel6ore cord-264543-b4zwinh2 cord-263294-9r84f19u cord-264843-cwtdkylo cord-264042-4hc2i25r cord-265052-hfuvm1oh cord-265799-qda5awuc cord-264779-71s7e18i cord-265053-x70501t3 cord-265721-wmz3wywi cord-265082-gjbabh4g cord-264924-ds6jv5ek cord-264972-hrbo3awj cord-265111-d44ireu5 cord-265278-wf5pbvvt cord-264952-0t0t4x0y cord-264610-kxebc12r cord-265230-ozyx8u64 cord-265818-wme1360n cord-265967-y4639p9m cord-265812-1hcp36cw cord-265022-p5cab562 cord-266010-ectnfv5z cord-265934-wjdxqj8h cord-266456-10tjzqep cord-265848-afkeuwup cord-265098-u5qssib9 cord-265262-r01u4jr6 cord-266294-ua22udlc cord-266079-nv28ppft cord-266255-898h9rl1 cord-265472-b1s4stvz cord-266469-n484zqq1 cord-266583-avhiqlgy cord-266214-l8pmhcd5 cord-266463-ci0g1dno cord-266429-0xaz8kbs cord-266722-qfn2dc1q cord-266450-g9vihgbk cord-266160-464v4g8o cord-266775-4npowkkz cord-266478-642m488a cord-266730-mio282vy cord-266750-41gth6o0 cord-266455-rbblg4pu cord-266475-t04pukea cord-266905-j9ljwqv0 cord-266744-31p212aq cord-267020-4mpc246u cord-266932-567lbktm cord-267142-ys7z7j8j cord-267124-8efdzlc0 cord-266512-xh6zed03 cord-267287-qodj254z cord-267621-oc8bw7ft cord-267357-7aap2cte cord-267525-tg4uwent cord-267041-i94lyfsh cord-267300-zbipv9er cord-268155-b8lqo52f cord-268140-s5lailkp cord-268049-7xqln70d cord-267132-nb0j6k3h cord-268168-yzvag38x cord-268347-xz6fptol cord-267788-ukz2wz4a cord-267947-dnv2xl0h cord-267402-kca05rvz cord-268211-egy8rgtl cord-268254-1mg7a17c cord-268455-btuzihsy cord-268252-6g0vbd08 cord-268632-p1rsz8fk cord-268324-86a0n0dc cord-268561-vq1uhj5i cord-268879-ajd7ofc8 cord-268531-igjeai8c cord-268540-wrjzr3ws cord-268326-sbz3uk5h cord-268886-mpceglk1 cord-268617-1t7yaoct cord-268843-zml9lbve cord-269051-nl0jfqxt cord-268952-3j43p9j3 cord-268939-ws74xprt cord-269087-f9hyntvf cord-269031-sz8ieltb cord-269280-1zbxjmxu cord-269099-q5nyzlhs cord-269009-0i2bvt77 cord-269564-r5mmsnbx cord-269289-6uog10j4 cord-269190-w74bjtq1 cord-269205-g6eyvnou cord-269275-b7xxk48t cord-269105-yuphgyrn cord-268974-7bqh1yas cord-270019-er70ehk4 cord-270079-vwnzp6zj cord-269425-e9iyso7n cord-269345-5tlyy8jp cord-269554-fzu6dy4e cord-269469-7pmnxi9a cord-269690-6r2bfydw cord-269503-ij4u980v cord-270294-g95skuik cord-270509-roc93m4f cord-270153-krhkqcev cord-269591-lu415jcp cord-270348-5804ffwx cord-266713-rghowch1 cord-269981-xm0by310 cord-270124-tqhkzd2w cord-270210-gfy2ytg5 cord-270327-v4td3zsa cord-270525-nmebqrb1 cord-270391-703js942 cord-270388-nozh463l cord-269835-mz7i66qp cord-269511-bfd1dmt3 cord-269776-hj1s3ipp cord-270712-v6nnnzhm cord-270776-oulnk1b3 cord-270665-z4l3lq39 cord-270654-cz2y6ta9 cord-271603-zy4l9vtf cord-270245-zziwb2jy cord-270763-idkylpb6 cord-270723-cjfglili cord-270876-kul6bs3w cord-270740-3su8pc3f cord-270933-ecmg8kti cord-271180-cnrs0zpg cord-271358-5666nsb9 cord-271149-qnhlfozo cord-271220-sntawlnf cord-270799-2pmpspuj cord-270628-jtj30v0r cord-271262-xglhx928 cord-271887-blwrpf38 cord-271212-y8denvju cord-271660-5sfkhg19 cord-271871-8grkln6o cord-271920-1dzkgt6w cord-271896-1ad18z11 cord-272427-jqs00ilp cord-271944-oxtus5vb cord-272143-6ej3eibd cord-272553-bcmta2he cord-272318-8yfg1j0o cord-272727-a5ngjuyz cord-272071-445ivhx0 cord-272585-346ef6qy cord-271483-33kuvpl7 cord-272419-y3ebt4jm cord-272135-a09bf50o cord-272154-nrm9ulj5 cord-272112-egsha2j7 cord-272975-gzsd4ybt cord-272655-qeojdpez cord-273090-fdzkfo1u cord-272630-2na1gndu cord-272677-6t9kl3hq cord-272778-aixiioii cord-273045-ele1cz86 cord-273426-55vu6b3u cord-273641-8l57mnjt cord-273602-cq276tj8 cord-273869-buavj9mm cord-273283-gb0m6fue cord-273175-bao8xxe2 cord-273567-8fp3a9h8 cord-272976-pb2bjpop cord-273091-40gda9n9 cord-273119-jfy0iviy cord-273875-vpp0l6ij cord-273929-kpcmy9x8 cord-273695-p5p7kvpp cord-273408-jtpaue0z cord-273587-nja58vxw cord-274199-3stjueja cord-273614-qmp2tqtb cord-274184-hm516x6p cord-273913-xem3alih cord-274250-95yzt1gj cord-273317-2e3vmdx4 cord-273758-hhd8xnve cord-274481-k1dp1ilv cord-274542-fpzk5k79 cord-274008-p3st70u3 cord-273945-b1lekw47 cord-274494-heu6rmbt cord-274666-0d8oz51l cord-274632-d9z0m2l8 cord-274331-0i2opmcn cord-273996-z5vlw6nm cord-274557-2071770h cord-274782-yymo9i6r cord-274563-jimw6skv cord-274556-531jlpwr cord-274282-hvx5m2bx cord-274121-3w6kc0c9 cord-274779-0emfl1e5 cord-275041-fcdwitxy cord-274934-s8xppipe cord-274355-6hiutrct cord-274245-pgfqkwqg cord-275110-safr9z37 cord-274860-7ec2jcoq cord-274802-7ioiwsd8 cord-274871-jlquvz51 cord-275257-upj8mvzn cord-274324-obhrbxu4 cord-275185-9br8lwma cord-275260-xuhxqkyj cord-275518-p03sl946 cord-275266-e6omvo5x cord-275214-mqvw0219 cord-275004-qzg03dvg cord-275477-blu6wjhu cord-276249-9opsg7p2 cord-275349-b35pt3mo cord-275154-vwnpred5 cord-275340-q8d7rvnj cord-276241-4g6pa7kz cord-276132-tv5y1eqc cord-275440-fl4dsu7d cord-276264-wgzh3f5m cord-276288-upv2o8f6 cord-275272-qdg8sqpy cord-276267-77903fld cord-275979-cx2h5bsw cord-276303-lgywz9ea cord-276234-2nkeq4ud cord-276359-syr9av09 cord-275506-3t5gf66c cord-276524-th6eu11h cord-275742-7jxt6diq cord-276405-yfvu83r9 cord-276090-n8c2jpr6 cord-276438-nynri6my cord-276343-sb3vd7fq cord-275913-85u6v3ib cord-276495-q22jnkn2 cord-276635-0ciy732e cord-276327-wyevh4xv cord-276676-lgt0rzob cord-276621-9exp8e7h cord-276856-88d3vzbs cord-276927-rxudwp2v cord-276782-3fpmatkb cord-276784-8lmg97zc cord-276592-dsilwfl1 cord-276834-20lcihf4 cord-277189-fe8ego7f cord-277148-xzpuc22p cord-277096-zvb7n9wo cord-277260-7se220oz cord-277014-iz8jo44e cord-277328-9s8fwg1h cord-277535-u283k70i cord-276641-40r4mitg cord-277539-xt2nt11e cord-277201-jzjxsetx cord-277146-4a4vz36h cord-277498-hdhq99k2 cord-277207-2my86ums cord-277576-3dvt6uj7 cord-277430-x02u7oh0 cord-275828-c6d6nk7x cord-277700-nxm1jr0x cord-277399-0w8is9xm cord-277178-nbotxv35 cord-277486-12uah5qi cord-277323-jqr2hkv2 cord-277210-xaj2623u cord-277818-8w15dz20 cord-277803-7p1qu2rf cord-277811-j58qvyum cord-278325-ykcd7d59 cord-276758-k2imddzr cord-278477-9a7gmzz3 cord-278300-6cr9h7no cord-277889-8u685f45 cord-278549-br9rr713 cord-278364-58d8kfdf cord-277739-eb4z3u66 cord-277992-49mantab cord-278547-y0hvq0qf cord-278332-fbksw3om cord-278937-lkuuftno cord-278106-ev1nx60h cord-278672-pxzsntfg cord-278943-f80ucqqp cord-278682-s4gfbsqy cord-278984-0zof6s4d cord-278319-44bvju3g cord-278993-w5aa0elj cord-277643-xh8z9v0m cord-278536-b4eyegx5 cord-278592-67y4f9av cord-279052-8hxdfdls cord-279134-s6c7m94h cord-279435-ffgd2ets cord-279111-jaa45kyc cord-279158-dsnniuo6 cord-278838-qraq5aho cord-278256-dmrtsxik cord-279299-5djtiomq cord-279357-83hisxro cord-279456-oouylyx9 cord-279056-mmcoqtb5 cord-279557-hk77e3pp cord-279480-nqp1pc9v cord-279238-d49jvws2 cord-279197-cesemos0 cord-279550-7u2hksxm cord-279513-m4jdc8ua cord-279667-ikfduu2k cord-279570-lgbqpfh5 cord-279396-qmixem8i cord-279846-g0ro8pbb cord-279732-cea0nt8z cord-279790-zzvetjrt cord-279571-chiadufa cord-280070-c1bkhgaz cord-279719-z0wuajpx cord-279483-gwikyux2 cord-280129-a97rvtzl cord-280278-gq1hnnwh cord-280097-f7ky61ds cord-279736-udsbcqfs cord-280507-1nf2ycp3 cord-280005-i9fp5rys cord-280280-9jr7ekbu cord-280628-ok62havd cord-280060-gzby85u9 cord-280360-rh37d5wc cord-280111-6hiuzkvz cord-280348-vrnxucye cord-280848-z0sbztkw cord-280030-neqycg6v cord-280233-avmisu31 cord-280821-kc0ut4oy cord-280241-h16s6wwm cord-280984-2j8ckz14 cord-280996-anq680a1 cord-280961-fka8c69p cord-280431-tuzdng4h cord-280944-uphs5gvl cord-281060-1ud5hzlh cord-281130-9tawihti cord-281003-7pdhxdzc cord-280551-9hoxy5ok cord-280794-k591vqji cord-280554-9jp85yzz cord-280358-ru2hv6pz cord-281039-a7q5nzwn cord-281064-b69p44uq cord-281175-og3myz22 cord-281283-h6yai7sx cord-281276-rffp6qe2 cord-281106-vzb5xzza cord-281346-bjhdy8mg cord-281561-r10y2sgb cord-281391-0qkku2jd cord-281752-64mrflcr cord-281887-b511bjdy cord-281332-5mddyv0n cord-281344-iswbgqqe cord-282183-k0pn0ie2 cord-281945-jvnjzjds cord-281566-6v5zfue6 cord-281298-qheq9lc8 cord-282483-0zsvhoog cord-282219-7kzbnymp cord-282097-a1pwq4fi cord-282043-cs1oyohu cord-281729-z321pebe cord-281733-bsq0ewac cord-282660-9x937eus cord-282589-xof56j98 cord-282361-gje78nb1 cord-281804-lhnw8jx5 cord-282535-gnuhjs32 cord-282430-u5ukqc5z cord-282021-m1lh7mzd cord-282151-mai4eggf cord-282724-zzkqb0u2 cord-282704-qg2o0ug4 cord-282474-74273qgk cord-282730-pawasfh4 cord-282610-zim7nond cord-282504-m3npy0om cord-283141-dh8j7lyl cord-282963-p04c5nn7 cord-282780-34j7gquo cord-282783-ps5jyjkl cord-282956-f7if9e5q cord-283165-mdkr9qo0 cord-282867-kbyxdegu cord-283513-3f4rsgzm cord-283738-v3h7p297 cord-282912-jegpgqqi cord-283215-dgysimh5 cord-283517-7gd0f06m cord-284163-3jmqzemf cord-283779-mudwcypl cord-283583-pwlbrxn3 cord-283682-4fcyoyea cord-283267-72wrzw09 cord-284038-93s3ffoy cord-283826-lgyc3sro cord-284188-ujdla954 cord-283719-zmizyx7e cord-283806-a6exd6dn cord-284042-awl5bb0j cord-283231-ju71zm7w cord-284387-cjziykrz cord-284365-g46myqe7 cord-284298-tcied4l5 cord-283969-wqrzaxsu cord-284454-malfatni cord-284175-5rre1kbn cord-284545-vn60yd46 cord-284983-xvtkso79 cord-284332-p4c1fneh cord-284526-a5kgo4ct cord-284251-brn5izwo cord-285354-bp2dozzg cord-285472-cj5r3xt1 cord-285469-b61y9ezi cord-284979-lyt98od1 cord-285360-svczr721 cord-284995-8lyr3gs4 cord-284576-nemh4wdo cord-285897-ahysay2l cord-284804-6i5zbmm1 cord-285291-pep4opiq cord-285818-eh12luma cord-285755-zblitbo0 cord-284944-hcgfe9wv cord-284910-vjcrhwqz cord-285226-4ydvjmr3 cord-285414-vd2d7db2 cord-285467-uxfk6k3c cord-285757-fiqx4tll cord-285867-61y4aamj cord-285907-xoiju5ub cord-286227-foeb0g7u cord-285588-ug7upa3r cord-286418-9ho5fg3h cord-286403-gdkwabcj cord-285298-r7p44wpe cord-285732-xew5ar1e cord-286096-h275nner cord-286525-0354438s cord-286638-bqxyb61p cord-286477-0euaaspo cord-286237-x6dr6rsh cord-286574-t9z2ynt5 cord-287102-o19uwryp cord-285772-4xt4anq5 cord-287048-5od0ssyk cord-287117-3v9nyagt cord-286683-mettlmhz cord-286293-f5qg7vcz cord-286611-e1i1wemo cord-286843-8qh1pblc cord-286853-9gbel3pq cord-286743-z0e5arlm cord-287515-oe7adj91 cord-287468-e5h4tmy6 cord-287373-7xjn05k8 cord-287222-wojyisu0 cord-287508-133inel2 cord-287210-sars5dmi cord-287367-1sdt9zz8 cord-287161-hqrql1lh cord-287520-51kmd2ds cord-286607-5i406twr cord-287544-n32iscmr cord-287558-yc8aw2pg cord-287648-nhsn4cru cord-287376-wxldnlih cord-287786-zfe0el8i cord-286334-d9v5xtx7 cord-287538-qbf5lv7d cord-287742-y1j9x5ne cord-287505-ihqzpdar cord-287497-93oiiqqi cord-287901-56goaqir cord-287765-nsdequl9 cord-287957-diyz54qy cord-287874-wl0wlxh6 cord-287732-abzpfdcu cord-287895-63wy5ztb cord-288033-9xu1ujcq cord-288040-uuqfvvmk cord-288102-iom6lu7o cord-288158-6gicgsj8 cord-287953-prn8cnvo cord-288067-36amafub cord-288222-8fqfbys2 cord-287758-da11ypiy cord-288009-8i3gsq9p cord-288271-p074ffpt cord-287991-10jz1dz2 cord-288197-drto66xt cord-288558-rthnj6wd cord-288051-wp8v2mc5 cord-288255-p8uzrsbd cord-288181-9thl46oe cord-289006-7dv1zsp9 cord-288371-uyj4iske cord-288509-l6yn2er7 cord-288790-5uzgenty cord-289179-3zfur0zh cord-288575-srpc68t8 cord-289064-435bp4rt cord-288606-h8pmqwmk cord-288810-ab7k70c4 cord-289046-frhpt8n9 cord-288552-7lp07v5i cord-289311-0wgafqdz cord-288697-9dywuhkc cord-289542-u86ujtur cord-289054-fh95b5n4 cord-289457-06gwrpu0 cord-289115-bntcn0m6 cord-289690-af6lsj1g cord-289219-qjxdggz3 cord-289719-64ugdvfe cord-289322-5ciaonf0 cord-289088-7uoia564 cord-288580-onzzpkye cord-289008-c4cu3vrp cord-289574-engwi8h3 cord-290006-63sa00ju cord-289169-3u7qgxud cord-289581-aozg3o9o cord-289930-7xm6q68s cord-289114-ifnk41oq cord-289533-hip9qtu5 cord-289816-rlwoy8ms cord-289859-b1k9uyp6 cord-289553-gygvhzcc cord-289854-p8okfa4b cord-289806-6ihptx6n cord-289775-40bi87iz cord-290041-zxlq63n5 cord-289828-3k088z9n cord-289612-4x5t4c5u cord-290028-oyd7vzj6 cord-290081-pjg00t7g cord-289973-1mczuxsy cord-290200-csmisulw cord-290551-a02tueuu cord-290401-t87i3exo cord-290267-ke696q8j cord-290065-ouua7wnq cord-290295-gl144dh9 cord-290658-r2bqqovo cord-290341-ei768v4s cord-290051-22gwwrpw cord-290712-flj352ql cord-289852-4uxb70rh cord-290750-85731og8 cord-290195-8uaai9nv cord-290975-2kmvyovm cord-290326-umv0q4d7 cord-291016-c83fs5ih cord-291265-qmylxndp cord-290832-zmj59rc3 cord-291052-nstfe15a cord-290611-fhaguv3f cord-290947-5ewpvo4j cord-290856-6de0mwg0 cord-291340-8gj0ofmp cord-291024-9g4om4sf cord-290836-jldfrec9 cord-290771-18dj37dj cord-291168-4u4cssky cord-291397-look6ddt cord-291025-u5z8zji3 cord-291176-evb6yt0r cord-291244-o4isx15k cord-291388-tt9eq7e0 cord-291469-cohrewj5 cord-291413-cgec7150 cord-291624-fod0eyuj cord-291686-kgewmqg5 cord-291588-tp89j1kk cord-291430-rsu6xviv cord-291417-p49ukyhx cord-292056-dtdyxhq4 cord-291670-mqj071gp cord-291697-wpnq9wc0 cord-292315-7vwybku8 cord-292345-zc209dfx cord-291566-jwlvustd cord-292474-dmgd99d6 cord-292054-x0saq938 cord-291687-kwu0otpi cord-292561-iy06b9h9 cord-291873-inzzywps cord-291855-wtwz94sy cord-292620-t8ocqm6g cord-292394-91b3mm6c cord-292493-lx7zfgoi cord-292335-al6v3b9x cord-292485-vk5xy3zn cord-292350-cmrtg91a cord-292387-2xv3wgaq cord-292826-lus0tqmi cord-292094-vmsdhccp cord-293285-w8c3ma8l cord-293167-3bd3adip cord-293143-1k170shh cord-293333-mqoml9o5 cord-293575-h3wc7j4v cord-293180-f1ulk9ce cord-292952-z7ajsf2r cord-293570-gh6ykmea cord-293730-dlqo6fep cord-294057-fbox3a5q cord-293086-6282sb6b cord-293522-gg706q8s cord-293964-hz5uow2b cord-292856-7hjzzxtm cord-294487-hcuzxhb3 cord-294073-65h2mkdy cord-293547-29i3u83s cord-294108-uvnh0s9r cord-294336-fqobpo47 cord-293852-r72c6584 cord-293472-d3iwlpsr cord-294270-do6i6ymq cord-294184-jte9xx5e cord-293634-4rryqbnu cord-294349-ps3qlho2 cord-294443-w6p3f5qc cord-294617-i8j36bol cord-293922-knzv4jvj cord-294139-78c5h7la cord-293704-tnik6sd3 cord-295123-x2gxgave cord-294636-xes8g0x4 cord-294294-66udu5y4 cord-294527-fct2y5vn cord-294079-px9c20il cord-293740-4c3yemi3 cord-294628-ecg13s7a cord-294371-xot2oj2t cord-294933-oc2glu4a cord-294907-i836d6im cord-294959-xy8976jz cord-294064-vdpak3fm cord-295514-vhymj0rw cord-294969-57xgqf2g cord-294768-bs6thjw2 cord-295216-eff02z0i cord-295086-tc3re52f cord-294557-4h0sybiy cord-295332-wlnss6bg cord-294700-pb5k21da cord-295323-snrt9odv cord-294593-mh1uh1b3 cord-294810-mq9vjnro cord-295414-v10454ns cord-295144-tyyc81uc cord-296018-lgx5k2kp cord-295700-lzaxzuwe cord-295371-ccqne6nu cord-295800-w0dup04b cord-294788-9usyb1nn cord-296182-hhswage4 cord-295971-jtv1jj2z cord-296113-syi2fwuo cord-295798-x7or932x cord-295523-5pv7kw6i cord-295794-glcg36si cord-296588-q2716lda cord-296494-6kn4mr04 cord-296013-6ej3pd0u cord-296562-3h2oqb9k cord-296605-p67twx7a cord-296440-18vpg419 cord-295703-no45mgyd cord-296331-i4hyzqcv cord-296694-2js639bk cord-296219-zzg9hds0 cord-296676-2anl2agl cord-296607-h2zwlyz7 cord-297127-nhgm09db cord-296881-2g81sjnl cord-297208-f4ob3ox6 cord-297132-lhfa9fl5 cord-297093-ld89vmct cord-297138-t8b3914h cord-297327-19dfgfz6 cord-297532-ktiwfcop cord-297638-ab70s980 cord-297832-picpuzvo cord-296773-5o4hr6ir cord-296936-5gkx4jxa cord-297759-arg71du6 cord-297414-zq16s9ud cord-297494-6yxmaihl cord-297836-y9vt6wvu cord-298067-awo3smgp cord-297001-4g3wb8qi cord-298325-2gm4fnqi cord-298034-0ntxm28a cord-297518-6y2uzcde cord-298516-0eda4mzs cord-297506-1xjgsz4y cord-298679-w0yp4u19 cord-297840-z5l6vdsr cord-297425-vcqqssm8 cord-298094-ctikhqvr cord-298056-svwtfshi cord-298403-ilpzj2sv cord-298787-4vo9gpiu cord-299024-jkqdzt87 cord-298894-t5hyfum3 cord-298967-vjyh1xvh cord-298974-69xjc5yq cord-297870-m7n43k4p cord-299082-s8bm40vy cord-299681-smhto9em cord-299489-6v225vte cord-299222-vmofcrim cord-299570-1xz5r95f cord-299124-g70v4crs cord-299333-qu0bmov5 cord-299156-1dwsm3ie cord-299449-226dd23u cord-300038-1fjb6b8e cord-299881-weptfpa2 cord-299835-92karhpl cord-300356-oorac5he cord-299621-m4kdkmey cord-299254-kqpnwkg5 cord-299750-zkrlm3ds cord-300344-57vxlctl cord-300995-tqz2bkdo cord-300044-vn4c6wh7 cord-299679-6z9e5gi6 cord-299784-xxxdjfbc cord-300608-eju7wnb9 cord-300774-5mrkmctl cord-300559-vuuxthx2 cord-301011-xbuqd0j5 cord-300866-cso6l6ze cord-299346-f13xly6q cord-300183-z3fwtwqb cord-300510-fhpkdqr0 cord-300697-p96i25uc cord-300458-jeuwaj50 cord-300445-qzu4gz2d cord-300080-l0fyxtva cord-301079-n1nytr6k cord-300303-d4qmtysd cord-301281-yur5hs2h cord-301391-5dvf1mi0 cord-301342-ikvpkhfp cord-300811-l4y7df2f cord-301146-no9pw4gn cord-301087-9vl5pqi7 cord-301592-n5ns3m34 cord-300963-1n1f8mf2 cord-301832-6czrdmzb cord-301811-ykpiorgo cord-301805-sb0ij8k7 cord-301340-lhh04pum cord-301579-q23nhmgs cord-301590-70qmpccs cord-301402-andxwyi3 cord-301521-mpm43aga cord-301148-duttw9xn cord-301947-b6nwaost cord-301992-oin1m0uq cord-302062-wqmynngg cord-302115-r39ser2c cord-301779-y07xjnpe cord-301800-ssdzd43t cord-302244-uwicyuhk cord-302389-h7jm1etb cord-302316-raf5rlkq cord-302215-sqrbj5r4 cord-302459-grs2x26l cord-302448-2r4rtixg cord-302684-r4ger87o cord-302177-8w3ojgd4 cord-302413-7a80jff2 cord-302403-kahi8cbc cord-302788-kg8zwysg cord-302667-ei151qpd cord-302695-vyo3w2a4 cord-302226-0rhgmtbo cord-302862-znnlyz3y cord-302864-2xnq1oq7 cord-302382-eifh95zm cord-302806-1e99cygs cord-302576-fv2ib5vc cord-302756-343y63e5 cord-303145-rc5luali cord-303600-96vtj89w cord-302997-39o08tt1 cord-303192-il3s8lgp cord-302821-b9ikg0xy cord-303017-4zx94rm6 cord-303244-5tfrmsm7 cord-303065-dyg2baog cord-303460-abutfxtf cord-303054-s1clwunc cord-303363-uu9hb1c9 cord-302800-852w35od cord-303880-zv4nbz9p cord-303661-etb19d6y cord-304010-n4gxxl5i cord-303349-0kn7apl3 cord-303483-wendrxee cord-303718-7bpap31f cord-303517-8971aq02 cord-303816-c4z9ys3q cord-304090-l5rocsk5 cord-303787-dx1n8jap cord-303819-w1785lap cord-304573-3nhglbw4 cord-304602-jpxjiaru cord-303703-ekhwb5xb cord-304271-vyayyk50 cord-303860-jpy373ph cord-304280-2a84u4tm cord-304601-e6qlx1r6 cord-304248-sxbyxnxn cord-304593-cugypxp0 cord-303791-yw80ndg6 cord-304949-mf3utolt cord-304474-hfv43e9m cord-304255-7xs9cit7 cord-304457-8g36h1bz cord-304418-k9owyolj cord-305076-v56y5nyt cord-305134-s7h6bpof cord-304798-j2tyjo1j cord-304321-y177sqee cord-305397-4dx3q6o6 cord-305139-851v2qr3 cord-305520-7gxmdo56 cord-304399-7t2mu13s cord-304791-wv4qu9xm cord-305283-1bg1ykui cord-306092-5bi2q3jj cord-304972-aktfbriw cord-305205-ilxxkm0f cord-305498-8tmtvw1r cord-305838-i0ck2oo0 cord-305650-su6furzi cord-306062-g9hk1iq5 cord-306149-sd0s0jup cord-305422-t8azymo7 cord-305304-d3x734nu cord-306090-i8sriw08 cord-305405-me4gebvm cord-306266-8qdrshz3 cord-305479-o47mv4uw cord-305959-x061q8t7 cord-304479-uxp1kg86 cord-306108-ja0wyr5w cord-306595-ru725fbr cord-305534-936peb1n cord-306670-c2jm0g88 cord-305582-3hmsknon cord-306790-82nltfk3 cord-306016-2gudro8v cord-305786-06dpjik8 cord-306351-ka6asw3m cord-306154-nm0g79ih cord-307100-w33e2078 cord-306997-84pjfawk cord-306377-s9j21zsy cord-307160-1vz0gw1w cord-306646-6c7n0xir cord-307258-66lwpblq cord-306896-khn8epxd cord-307217-0agij3z3 cord-307660-onz6vfre cord-307285-bxy0zsc7 cord-307653-nyr6mtj1 cord-307690-1qqyixun cord-307758-a4sgt66g cord-308071-1bk3xuwf cord-308010-ix0xi5jb cord-308390-ei96iuw3 cord-308184-w8ewm8ve cord-308075-1ftswsm8 cord-307309-s0t4kp2x cord-307862-a082sghm cord-308252-qwoo7b1l cord-307710-dlpfbnb1 cord-308169-a0ft6wdy cord-308112-w96ncfla cord-307287-zpq6byml cord-308002-abgv87e4 cord-308195-nlibv0u4 cord-308313-3speddao cord-307808-0t6sw0zp cord-308466-f0iu6sje cord-308907-elz62jlg cord-308212-l8flyso7 cord-308491-fc46k594 cord-308445-3j2q83ll cord-308906-et7duogt cord-309214-v2iqgjc4 cord-309207-n8u8ddv7 cord-309024-pu830bn9 cord-308979-qhlvd2mt cord-309236-p4c2d5y3 cord-309001-erm705tg cord-309194-jtouafgd cord-309370-g8d3w7it cord-308803-i934doud cord-309421-725u6dau cord-309395-5yan9fcn cord-308968-m4pzsfkd cord-309441-obojsf04 cord-309026-l2rh9bie cord-309561-m43v332d cord-309302-n6cd2fc3 cord-309323-yflng8m3 cord-309507-oe4i6v5x cord-309482-frawgvk7 cord-309238-7lbt0f03 cord-309751-7elnvjk3 cord-309360-cpis1l4u cord-309728-7vfotgrr cord-309706-kikx05dj cord-309829-3dlfcy31 cord-309735-bwa1zo07 cord-310010-oxgb6xnv cord-309962-phwq8rsf cord-310117-19qsszns cord-310069-ay4af6xr cord-310166-gt6icwul cord-309517-yh4d414y cord-310240-otf9ruvj cord-310001-qng7h5cj cord-310597-zy6ckr53 cord-310891-yfouizjb cord-310405-7fah22nu cord-310661-hrvuhkq9 cord-310690-50z2kdaj cord-310084-taaz6mhs cord-310539-8zk3hkgj cord-310663-504p29hv cord-310823-xksu8fn1 cord-310901-oooat8xj cord-310974-hz37yf39 cord-310205-j57x9ke6 cord-310177-4jw1lkli cord-311341-7ox30d2u cord-311275-ysr9nqun cord-311043-nidu7om2 cord-310976-24b3c3a4 cord-310902-cfci8lef cord-311074-j3fw4dfc cord-310676-125o0o7x cord-310685-gi2ycrfk cord-311373-ngs7baoc cord-310917-9sk8gdh8 cord-311044-kjx0z1hc cord-311730-189vax2m cord-310779-4puiao40 cord-311176-dlwph5za cord-311579-4jhoatkw cord-311673-z4hkw17g cord-311682-npi03i7q cord-311752-stqrf50k cord-311215-x3b7ewo2 cord-311942-oju4gosw cord-311970-o9xao5rl cord-311848-8n9ee57a cord-311000-abntwzuy cord-311418-7core0y3 cord-311847-2czqs84q cord-311816-j8c2lk7y cord-312063-5c2w2ct1 cord-312065-nqy7m38f cord-312199-jy3izkou cord-312249-k7dp776s cord-311838-ymn96yj4 cord-311957-3rmm1hfb cord-312313-guphuppy cord-312057-4zfaqkxm cord-312192-hxhohtmj cord-312012-6a7i72bk cord-312388-pc89ybxw cord-312609-gv1khfmo cord-312212-h5j4f0xq cord-312033-iarl77n0 cord-312486-rumqopg0 cord-312467-kbhljong cord-313028-0nhgxoim cord-312209-3yi1w44v cord-312677-rwznqiib cord-312614-63qzissw cord-312798-2cbgnv1h cord-312748-9v2bmbod cord-312572-i7r28wdc cord-312846-ef7m4875 cord-312795-0e4esl2o cord-313136-ab56mg6j cord-312754-3yhxcfr2 cord-312918-iof45k1r cord-313082-n3bo9jw1 cord-312847-2cg3ylfl cord-312632-g4250q6l cord-312684-3i2r2ahr cord-313294-ffgo56gl cord-313349-ikjivfce cord-313353-uwwih8v3 cord-313118-dv5xq2k4 cord-313728-08kwkbmd cord-313494-a4pms2ub cord-313227-6zwkfzab cord-313468-lloh1b0y cord-313239-0gl43af5 cord-313529-xm76ae08 cord-313628-6610z7xk cord-313693-qmkrn7pr cord-313684-61hkogdh cord-313785-8tipkksu cord-313976-q5j5kr1v cord-313528-rp15vi1o cord-313894-stgx36h5 cord-313836-mcm0xmzw cord-314088-ktj17dvq cord-314218-6znw9zcz cord-314070-8qz23nn4 cord-313860-mzs3ya0s cord-313989-bc7q8swu cord-314152-wd153s1g cord-314171-431buxxr cord-314378-cs9ggqwk cord-314280-kf2bo06e cord-315056-ohyb6oa0 cord-315311-azamwuzl cord-314649-1y3ocvz1 cord-314537-8a1vqale cord-314694-g0pes5o3 cord-315116-u7btx7nt cord-313474-1gux1gsi cord-315249-yclnl87n cord-315297-o8mwmjql cord-314826-usfvulc2 cord-314349-rhm1ii3d cord-315397-cm3mc7we cord-315188-a9pvugjt cord-315181-emf4i6ir cord-315195-m2xqlct8 cord-315569-e56c5g8h cord-315486-pjb5v1tc cord-314106-r3axl3w1 cord-315574-jq1p5t8w cord-314449-ukqux772 cord-315970-m5o962yw cord-315149-71bmj5il cord-315696-43wmazxa cord-315834-ashjw2xs cord-315490-xs5v3uc3 cord-315424-i3nnennw cord-315871-anguylf1 cord-316067-mlcczr8c cord-315157-2p45frlk cord-316003-xt59voyt cord-316170-ihh0pxov cord-316135-kevyw19w cord-315730-fzgxuak7 cord-316083-f1h2j6jx cord-316137-6zdxfv8v cord-316306-vfez5k02 cord-316029-z708c3ex cord-316432-xemz7zn9 cord-316728-vyfkmniu cord-316666-qif1k62t cord-316117-o29773cz cord-316845-k9zvsfvj cord-316118-ph582weg cord-316095-jzyb4jn5 cord-316673-ffkh13xm cord-316370-t802kjpk cord-316376-76beuk0c cord-316572-7ei96rrn cord-316647-jj8anf5g cord-316987-3nhqx2qn cord-316522-fbw9x3ik cord-316873-2gwl9m94 cord-316835-qf0c91vr cord-317075-zegearxa cord-316616-j82q99in cord-316938-64jxtg9y cord-316764-ps89rxuy cord-317265-n6x0r58i cord-317028-f3bpwm5j cord-317242-e7000i2u cord-315598-qwh72inx cord-317535-zep5axfo cord-317344-wznzmssz cord-317604-j8b64a1a cord-317468-pnxni1x5 cord-317566-6ch6na31 cord-317809-umb8j63t cord-317918-pl625ela cord-317689-gp4x54pe cord-317932-5sqj2klm cord-318282-ocgfgx9r cord-318167-b25g6zkp cord-318063-bainw3d6 cord-318021-4qrf5m8s cord-317952-4oa9hfb4 cord-316743-q6gbxghx cord-318094-losjbgn6 cord-318311-aakpbbvl cord-317575-srg9cyqp cord-317966-ut6tzc8s cord-318229-29cgwivt cord-318694-370ccaoc cord-318262-w8oixzdg cord-318355-38x3f3ee cord-317085-qc8bfb9g cord-317151-cxx5pcln cord-318333-rzhrgp5q cord-317811-mxsujb5u cord-318954-pj5lsvsa cord-318909-h5b7mncf cord-318803-xpa49sxt cord-318326-q9fnbg8n cord-318944-13zk6cco cord-318873-zwot69s3 cord-318830-a3n4c5d1 cord-318369-y3wtfqrn cord-319333-jwbgytwd cord-319037-77l9wdyb cord-318312-v1c3qm7h cord-318520-hgjv7ot9 cord-319400-lghjiw5p cord-319849-3shr5grg cord-319742-ypkt01rn cord-319218-mejvlkfg cord-319930-ymqnb54a cord-318808-1cfwj5uq cord-319615-p2labgd8 cord-320572-94fvtj4a cord-319013-oytqcifa cord-320445-pdvkyzci cord-320612-vam0bli3 cord-319567-4t5t8bcx cord-320349-6hbuq0k7 cord-320599-hxn4bgec cord-320184-wacoz5t9 cord-320811-9sm7iz5x cord-320149-3q4q98a6 cord-320634-x7a3k5xu cord-320477-zbp8a8dr cord-320267-n21jryi2 cord-320877-1i0hzfjk cord-321346-epsp3bbm cord-320788-ln8ddyuj cord-321064-pe8466n1 cord-320632-369kax2m cord-320892-dcfi5u04 cord-320663-xypg6evo cord-319805-b6ypt5d0 cord-319823-sp5wibeh cord-321543-qdmvn44h cord-321149-hffj7s4o cord-319706-2e9jrv0s cord-320695-gq7k331z cord-320864-k9zksbyt cord-321030-isc3p46t cord-320831-owfnttqr cord-321748-9a54ekac cord-321768-oevswvvd cord-321311-v2i1caug cord-321461-1s3y9kc5 cord-321651-7e8dwcur cord-321983-566pbuic cord-321237-ynhdii60 cord-321552-lsz1onrj cord-321594-x5wv9p7n cord-321788-z2y1ywdq cord-320930-9yiu0080 cord-322009-0cwljo0c cord-321472-n4nnmlv1 cord-322063-96suqyfg cord-322054-whjisspt cord-322066-m8dphaml cord-321801-w66v5kzh cord-321837-0r86qxz1 cord-322052-zsbisk3b cord-322394-b18fv3r3 cord-321784-nubu5fuz cord-322322-woz6lwdu cord-322259-khknne8s cord-322439-86dojc70 cord-322102-4fi0y96f cord-322534-eikz07zz cord-321697-yua3apfi cord-322497-hdy3va8e cord-322746-28igib4l cord-322552-95bj65qf cord-322867-1yxxe5d3 cord-322590-twnlaq24 cord-322868-o3r0y6bz cord-322448-s04e6po9 cord-322957-clf8f90t cord-322799-opf1qwgl cord-322663-a58e6pp8 cord-323225-ou7pppum cord-323133-gdg50omp cord-322990-q07yy5k8 cord-322893-av8hj005 cord-323024-blc3mnbj cord-323092-j2u0ny2u cord-322861-q7uk6rdp cord-323180-3ih0i81s cord-323255-elwfiima cord-323446-w2ci1bfr cord-322104-f1dukpso cord-323314-y3k9dntf cord-323470-lpeeugdf cord-323293-4gmnkg09 cord-323538-9dlr6kqh cord-323463-osf6t7cw cord-323647-q67fa0m3 cord-323809-bocidwg4 cord-323713-bc00vths cord-323273-q53wf6au cord-323582-7y8pt72r cord-323831-1qadv7r1 cord-323489-ro7kbnu3 cord-323910-lms3xw4k cord-323965-6mzzibj8 cord-323906-ro078y52 cord-323705-n2rec4i8 cord-323787-9lq8rkih cord-323980-rcyjthze cord-323761-9m177ozm cord-323816-3m1iu9j2 cord-323913-v32c2vda cord-324175-5c4ijkpm cord-324007-hapzf0fl cord-324041-lqokztor cord-324669-qca0uwxo cord-324666-fvk72o0p cord-324159-jv3lknl8 cord-324232-nupi7f72 cord-324245-cfiekxr4 cord-324125-wau2xq0x cord-324060-vvexfg1c cord-324601-s3rgxtg6 cord-324314-os1btxx1 cord-324148-bllyruh8 cord-323940-ubazgvov cord-324859-0yuhb5dl cord-324880-s1oqkqef cord-324843-r43u7sld cord-325201-yoy7kdli cord-324529-xbrdtxnz cord-324635-27q3nxte cord-324809-16zvqizl cord-325619-qmszgw66 cord-324619-y7gilopu cord-325628-pa3dkz2f cord-324944-ixh3ykrc cord-325234-skshcrh1 cord-325511-ot66dj3i cord-324918-36om8n2d cord-324810-92fosk3c cord-324679-rds8o5z4 cord-325655-1fktmpbj cord-325307-agaau27o cord-324798-qh0cxp10 cord-325316-uffxyas1 cord-325421-1ysn0kyr cord-325793-5vrr7msw cord-325869-3mvjc805 cord-325783-pqonn0as cord-325970-ivtunxrd cord-325766-hbppklm5 cord-325649-zzhsrytw cord-325863-3t73v4ng cord-325631-c7jwizpj cord-326185-gjte739i cord-325700-f102uk2m cord-326023-vwukiwe4 cord-325933-1qvpofvp cord-326272-ya3r0h1t cord-326703-akn92p1r cord-325971-volbaipv cord-326747-zwp13awk cord-325963-d0hvukbu cord-326643-obfvi3ms cord-326017-qw4qynqv cord-326468-xcy7v1tf cord-326851-0jxdnm1l cord-326354-fhafg41x cord-326751-fn43p19j cord-326984-o27rp468 cord-327017-b2refzfw cord-326807-dii4u9gj cord-326834-eeldyj2u cord-327165-vlyfbiem cord-326883-j7pbe50g cord-326991-m0lfk0a9 cord-326785-le2t1l8g cord-326752-45ckkv01 cord-327148-dzozl70h cord-327370-zo0n8wf6 cord-326994-y8p724s4 cord-327125-86ocr70d cord-327413-zdbnoy1q cord-327397-8rxjju0t cord-327214-kcbxyhhh cord-327432-ogw27tob cord-327545-y3vejwtr cord-327442-e02y93f6 cord-327349-rxb6zfoc cord-327611-g2ssh0fk cord-327577-c0d09cyk cord-327415-nu1msnui cord-327632-2hz94uuw cord-327764-4nlg26p5 cord-327720-m6cofbj6 cord-327481-m9r0p84v cord-327989-6p39cx2e cord-327820-4bm7b934 cord-327622-ezgufe24 cord-327818-1abweqko cord-328068-qoz85x3r cord-327961-ysatxwph cord-327597-fgnrujsf cord-328040-5qd05e4r cord-327609-no58ucyq cord-328214-2azb8789 cord-327836-6o66a4i5 cord-327690-di7hfghi cord-328484-4iptwc3n cord-328513-81yvcgul cord-328384-jzfr2t3p cord-327827-oliw4ee5 cord-327641-hqnem2zs cord-328438-irjo0l4s cord-328786-gkd9xcxa cord-328829-yywxmioq cord-328289-3h3kmjlz cord-328607-lzai90zq cord-329351-g9qlo3xh cord-328895-p75b7jii cord-328525-80xk3gln cord-328039-xt17gvcp cord-328113-eczjjc2v cord-329152-1ixylnny cord-328640-4g7revha cord-328814-s3963anw cord-328220-toeq4xq0 cord-329564-tmi1u224 cord-329215-awxfetdj cord-329863-r2vqsg5r cord-329453-ry1diso2 cord-330431-9txstz4n cord-330050-05nnihst cord-329344-06uk5sjp cord-329741-604gtqx9 cord-328569-1lx3fkv3 cord-329727-h47q76y8 cord-330061-q4xi260z cord-329582-y4gyw8vz cord-328307-378cfb23 cord-328294-gii1b7s7 cord-329877-vish6v8e cord-328147-61gtx2h2 cord-328487-glwslgjy cord-330368-rk31cwl4 cord-330676-urr9oqfc cord-330655-crfj5adf cord-330666-puhijixa cord-329444-t8ixrdpq cord-330492-kbob8z48 cord-329766-9bwdb6o2 cord-330597-nftwj0d5 cord-330136-o8df8szx cord-330359-c0l5xq5m cord-330831-3b7vfv9b cord-330701-k68b0wqe cord-330869-k5ro0edf cord-329985-5rji08p7 cord-329856-0m5mc320 cord-330369-75cotmn2 cord-330856-j1wqrc8v cord-331109-a8e7r80d cord-330573-rr2r8245 cord-329989-176cvimy cord-330963-w24q8sn7 cord-331317-q01uos7a cord-331114-lumfg138 cord-331273-1fixwxuo cord-331268-kzy33hdb cord-331434-2x9m37cw cord-330870-l0ryikhv cord-331449-0sow1im8 cord-330877-nsx4b4rm cord-330918-hsy8h1vb cord-331270-12zx0o2p cord-331487-jh34klbg cord-331481-zeaqi1uc cord-331452-y5lhawqo cord-331519-ye4dtna5 cord-331165-2yn1n3eq cord-331547-uqmjhhna cord-331533-0toegbv8 cord-331500-l3hkn2li cord-331762-b0yufidn cord-331604-jf6ybip5 cord-331827-amg309uz cord-332036-op6s8tr4 cord-331915-7idktu7c cord-332013-bl5d4xkc cord-332145-rw16o02g cord-332153-fczf3lzc cord-332709-0plblo4k cord-332087-xwturwju cord-332233-01rdlf8l cord-333340-ekok0mp5 cord-333588-3krh1xzx cord-333470-0a0i6vjn cord-332150-j76726no cord-332278-2p64ab2z cord-334524-8uqnlpvc cord-332861-7b5pzmk6 cord-333451-p2plpeew cord-333816-cznwzcn9 cord-333113-0k6xlmem cord-334367-w96iqo6q cord-333453-v3gap8kj cord-332055-lrpfzsog cord-332180-dw4h69tp cord-334324-remrcm2q cord-332788-8lq9qygn cord-334715-902pfxyz cord-334790-lav794w0 cord-333183-xyuj1j57 cord-332774-t5untewz cord-333429-bq7kfpby cord-332778-rf47ptj6 cord-333696-3ci9re9a cord-333024-1yrmun3z cord-332480-3uodkrkp cord-333375-d7cgvjsm cord-334408-w0yxz7zb cord-334092-50r3h7jv cord-333684-j1sg46w9 cord-332992-8rmqg4rf cord-333688-bykbyojs cord-335168-3ofarutr cord-333698-e73d9lbu cord-333175-klnxnxwm cord-334075-ruqd2c1j cord-335078-z7k59k8o cord-335597-anrzcsrt cord-334881-x9nxxled cord-334212-3gqzeakb cord-333808-deifddar cord-334235-ymsiihwd cord-335312-yp73z008 cord-334495-7y1la856 cord-333142-ek7hct52 cord-335759-io18c6z0 cord-335351-8hdok02n cord-333528-9mczqtje cord-335033-cwhm7v0s cord-332650-05oz5zwz cord-334188-bggt1i2e cord-333654-8rg99di5 cord-334002-irbpehts cord-333876-fhxkpbq7 cord-335576-b34nc3ay cord-335198-qp964238 cord-335140-njg0ln33 cord-336194-5v395xae cord-335593-cjb0daps cord-335338-wzxjn5ip cord-336053-cjq7szcn cord-335465-sckfkciz cord-335916-fh28qrt7 cord-333749-45v6b4tc cord-335680-wsczl68g cord-335095-epsi5qq7 cord-334773-yw2qgv13 cord-336306-hvy9ukhh cord-336252-e92omqyr cord-336258-dxps48bo cord-335719-tnimrff9 cord-334835-j6u8t8j2 cord-335382-fk4um9nw cord-335540-lahu5dno cord-335795-hdko0zdw cord-335141-ag3j8obh cord-335265-kuc3v5m9 cord-336268-azgswke8 cord-335892-hwahcec5 cord-336368-sudi4mdx cord-336201-fl606l3b cord-335918-uc225mhn cord-335975-m6lkrehi cord-336336-f01khqqr cord-336438-mlgxiyur cord-336390-ptnpgh3j cord-336395-v157jzvv cord-336000-v88bq4bx cord-335977-f00758o2 cord-336314-xf6zvvl8 cord-336423-rs4bma9b cord-336790-29im4gxw cord-337088-xxyhmn1t cord-336554-n8n5ii5k cord-336450-2ndan331 cord-337094-aa3ourc6 cord-336462-7dltsav4 cord-336614-u6alc6rs cord-336621-0w3rroir cord-337115-vtjsigod cord-337262-88qpfu6b cord-337487-1lbopaso cord-337010-dgy7qbl5 cord-337297-fkw8780t cord-337120-irpm5g7g cord-336782-0zkb39v1 cord-335744-haj5a7tf cord-337896-mct29erg cord-337898-ncrbd8rp cord-337302-fpz2jfuj cord-336563-hwemigk7 cord-336882-x9e6r0h0 cord-336488-opjjowcq cord-337906-qis8h3r3 cord-337520-qp0ga6q8 cord-337995-z4rcczki cord-337644-aobdzwpx cord-337665-roelk7i5 cord-336810-77wq9laa cord-336784-24qizp9k cord-338968-b1gg2ha7 cord-338146-am5gg1qd cord-336543-ydrmlujj cord-338192-2v9dbc9h cord-338517-1mxcssjj cord-337338-7uj2r0gy cord-337622-rc9pejmo cord-339015-qn8wbnlw cord-339021-mhdaov1f cord-338666-gg9qcpmz cord-337994-pkklt77i cord-337431-3rrvm787 cord-338900-8ojah695 cord-338668-z2z4gte2 cord-338729-v2suoj3c cord-338683-nzgnpi6f cord-338346-e3fk6gz2 cord-339406-81a7fkpj cord-338602-6n309bnp cord-338023-gb5jgqcg cord-338131-6y96eyoq cord-339333-7tpnbr8q cord-338605-3i5pvcgu cord-338600-wpfcxnyu cord-337926-6ddvqowr cord-338419-n8cmv8mf cord-337965-z39q8ebq cord-339266-glmshsh6 cord-339614-28s205p8 cord-338756-jzz250o1 cord-338741-gy3ovkrt cord-339517-93nuovsj cord-339436-0k73tlna cord-339737-7qdjea6f cord-339811-dms0rlmr cord-339589-dl2qpc0t cord-339009-wcoch07b cord-339044-qy4jab37 cord-339355-zkkj8a83 cord-340051-r9kn34wd cord-335802-1kiqfy68 cord-339455-b8nu34vv cord-340164-vzdyy656 cord-339705-x8l3zgfd cord-339956-o5o2yz1u cord-339467-ewqxf02j cord-339913-ps4nvvaz cord-339686-oybnk1j8 cord-339656-u0cpklsv cord-339885-mpzgrogd cord-339695-3ij5pjjy cord-339267-p3djwg7v cord-338135-zwo7e7gy cord-339504-8svo2w3u cord-338182-cetv78ba cord-338965-ewuqsfsf cord-339568-th2xmhb6 cord-339940-80757pwu cord-339471-1510mzmy cord-339679-9hghy9pd cord-340000-1e66aqih cord-339474-tsdq1rgz cord-340204-3gm58qza cord-340415-6fte7krp cord-340576-dabcs3w5 cord-340650-mwsa326c cord-340799-1awmtj52 cord-340826-2530zdeq cord-340687-99ad1rwq cord-340070-de7sfccy cord-340314-5oz3013n cord-340536-azlajqbe cord-342555-5r9aa7u5 cord-341627-21m8rdhy cord-341202-1pg7rq2d cord-340232-cadu5ah8 cord-340542-jz7ca041 cord-340253-lpner9f8 cord-340383-psjga23p cord-340880-2qop8tcp cord-340710-dmow5p7k cord-342810-41dghl0c cord-342246-tnjtd9n3 cord-342303-ddulfe06 cord-341197-e8m4oxma cord-340984-blkhfhe2 cord-340660-ocvy1ge2 cord-340430-x4oitcyh cord-338362-6zwvkqag cord-340651-g3518bq2 cord-342857-vj6sw2ne cord-340786-12vzsl6p cord-340766-aic570x8 cord-340811-w4x4falm cord-340908-8q7i5ds3 cord-341415-g781zhu6 cord-341531-w788qwya cord-341118-h5t87vf8 cord-342068-zhk3wmou cord-341933-dwki1hwu cord-342139-t2tukk0z cord-341284-jmqdnart cord-343052-dc9s2rau cord-343201-98scxky8 cord-341234-2zgfcrwc cord-342519-tjr6dvtt cord-341314-1mav631s cord-340857-teq5txm9 cord-342808-yonbowkb cord-341999-nosdj7b2 cord-341076-ox2ckhqu cord-341359-c34gyuv6 cord-342841-b1rucgmg cord-341670-o1v63zg8 cord-342786-dl8vjwfn cord-341919-8gnthufw cord-342809-wrxejwms cord-341591-ib8lsvku cord-343490-94vkfrtw cord-343743-6k3soh1l cord-342979-pvewvmmf cord-343393-8hdygwip cord-343023-e1uv7t6p cord-342451-yfy5jcw6 cord-342930-f7cw2ca6 cord-343715-y594iewi cord-343452-4m0ub9iv cord-342569-ja96xfns cord-343308-5i31ysee cord-342603-k0f33p3l cord-343819-1uki4b3d cord-343773-9f7ew8uj cord-343973-n5ogyxz7 cord-343437-cz1w9od9 cord-343876-2inr4mcy cord-343797-kpmz5kwg cord-343205-zjw4fbfd cord-343917-67qjqxqh cord-344004-z7pn7u6u cord-343877-jzkaee16 cord-343443-ljehete1 cord-344185-jz6ui4w3 cord-344117-lr6roxej cord-344135-pyibu6rj cord-343897-f4imrltt cord-344104-592r71l1 cord-343970-anocx4y1 cord-344270-874i31h8 cord-343566-epvswt7f cord-343832-xg3swuzs cord-344271-5aynmdsk cord-344389-aj9q73f0 cord-344131-e7phs0jd cord-344120-7t5ce2hb cord-344017-qldawc8m cord-344191-veug3dae cord-341063-3rqnu5bu cord-344302-p0v6sl9x cord-344508-a67vsux2 cord-344668-9m1vnpmo cord-344431-2wq7msqz cord-344486-iu5flbcl cord-345028-56hg62be cord-344765-agt60ksx cord-344709-5hy1e4t1 cord-345381-9cckppk2 cord-344939-rgxqobfw cord-345445-9t1vebey cord-345628-a4c46m2w cord-344729-sjjedgws cord-344693-znw3dru4 cord-345296-4z7yfj5s cord-344853-s2p2csrx cord-345517-ji4cet51 cord-345632-iha2c5zo cord-344967-t88pedeb cord-345371-pjbviagq cord-345762-khvcoqti cord-345680-10phij1x cord-345611-xv62h83a cord-345779-frspku51 cord-345655-fb4vv4my cord-345092-1ztfcpsb cord-345860-d02x3151 cord-345044-2fez1gu0 cord-345727-bcxkycjh cord-346061-pbghgitg cord-346241-w076l97s cord-346062-q0trgj12 cord-346288-9to4sdfq cord-346276-1dcp05rd cord-346607-1mewok8l cord-346345-jc9bq0zu cord-346987-fbqqf00i cord-345546-v7t26oos cord-347091-wbjpa5st cord-346015-bzeqs5oh cord-346459-tkt5ldyo cord-346389-gbmnoo84 cord-346594-tbsxgz43 cord-346894-iy35298o cord-347105-my9nioko cord-347268-vb6z0hzb cord-346664-ilebaqx3 cord-346496-crhv0gnt cord-347064-ljd121no cord-347293-fp8phk0p cord-347696-rsjwp0b3 cord-346616-kr500kgj cord-347058-kejcwlng cord-347255-fl9lur4h cord-346721-l6y3n21b cord-347375-5ucemm87 cord-348051-o1hxoasp cord-347280-jpwf55l6 cord-346205-vqgcq3qt cord-346558-u1e0kzmm cord-347607-ydbyonbg cord-347351-emdj66vj cord-347289-3yi5tz04 cord-346539-kxnrf5g5 cord-347121-5drl3xas cord-347414-t88654wo cord-347905-w0fnc43a cord-347238-yacn6xqk cord-347277-8bmcd22v cord-347697-uz0i6wfp cord-348202-6we8e60b cord-347752-2ejnva4u cord-348501-8cvtqj7w cord-348458-dwj90mbq cord-348172-q3zcn5pf cord-348881-w0moe21t cord-348672-e34103b1 cord-348975-plne3xlz cord-348423-zq86ms8w cord-348430-8xk4dt7t cord-348855-lnltoj1n cord-348813-v1sdodz9 cord-348578-chfb4i15 cord-348130-t9tysvr8 cord-349031-tbof9yqi cord-348755-2g5gi1du cord-349144-cvmebr3f cord-347263-ci6mv72z cord-348879-opzkodt7 cord-349280-12hc3mhq cord-348570-plds5kbn cord-349263-mmfrqyrc cord-349329-f0pbd968 cord-349210-8t4a5qqo cord-348422-werg9ofa cord-349533-51cex2sl cord-349396-a6zyioc1 cord-349500-603v8lfb cord-349565-g1emvmdu cord-350052-9431xqu1 cord-349678-79zlgjqi cord-349566-zx9kt144 cord-350065-frg7gvf5 cord-349838-p6vfzbla cord-350232-zml4o93t cord-349958-126yb5se cord-348364-jb0lvhq5 cord-349740-xed4aybr cord-350166-loxe11d6 cord-349949-jp0hvcg6 cord-350437-dq1il88y cord-349360-dv4lxx52 cord-349561-4mkiwg9k cord-349076-x3rjasg0 cord-349439-3z0b77r5 cord-350325-vu8v9epr cord-350131-rsrlri8m cord-348535-tvs1snq8 cord-350408-rqlkwoya cord-350529-yqtu059x cord-350401-suefuurq cord-350179-ltk5hfc4 cord-350338-lcsa06gm cord-350594-0zxq4lxc cord-350679-69lv4wbz cord-349775-zwslhjju cord-350990-tywbe4o2 cord-350589-h6hotlqk cord-351224-jeedo5mc cord-351195-2fdqu2l1 cord-350904-wyg8ikph cord-350737-nrtrhq1f cord-351446-j4ambec5 cord-351184-kcc3p3ow cord-350923-532lnnll cord-350200-1w5u3w8i cord-350639-iguadmw1 cord-351223-nnuoadh6 cord-350578-wyz5jyjh cord-351046-yq7287k9 cord-350959-bsbz3a1l cord-351457-fzj3ciif cord-351129-lzzyn570 cord-350718-jzliir37 cord-349408-2ser9zjc cord-351340-7y19ystp cord-351155-5bvo66yb cord-351531-wo1ggmmn cord-351020-wde3ki0k cord-351528-23lbs8al cord-351625-1we9wi1g cord-351825-fdog73g2 cord-352193-izzqdg3v cord-351555-hsgsuor2 cord-351896-j6h02ab5 cord-351762-n95ar9ci cord-351776-otx5qwyu cord-351722-3mw1te94 cord-351604-x4rsdwqz cord-352065-960xqft4 cord-352234-utjne1ef cord-351823-ldbscq4s cord-352401-tmt1pmw9 cord-351735-x1lng449 cord-352177-05sku8a8 cord-352302-are8vvhh cord-352304-tt2q5mgs cord-352159-qx16i7s1 cord-351819-ovpz36e7 cord-351431-xcqz9d3t cord-351597-bdazrbsz cord-352227-827987jf cord-352846-p7hhv297 cord-352544-7b6btzrx cord-352215-dhkvh45t cord-352579-ndcbmgfj cord-352828-4ecik6xw cord-352823-1os3kwp1 cord-352399-2xfzpw9m cord-352557-l7sahv5t cord-352914-jccxzit1 cord-352901-ia34l2ml cord-352969-rpt7xja6 cord-352577-h3652seb cord-353013-7cx0gnum cord-353059-39msyuxb cord-352889-fl61z3w3 cord-352937-htmp0avc cord-353180-hbwrzm6s cord-352905-ge3u32hm cord-352678-8f2ygul2 cord-353256-7nfklun9 cord-353281-leb7c7b0 cord-354127-sb8tovy2 cord-353228-fxrf5wsp cord-353004-ocnp758o cord-350571-6tapkjb6 cord-353375-92pu0pp0 cord-353484-q7d0ysbo cord-353200-5csewb1k cord-353648-rl9dts7l cord-353671-xjpzhsup cord-353956-gjv5cg3k cord-354223-0ckpz0bx cord-354103-4dldgqzf cord-353786-284qn075 cord-353987-hj94a04i cord-354372-vfvnjmv1 cord-353340-l0icku0i cord-354160-sca9bgeq cord-353293-vjdwh19x cord-353698-gj8sx3zy cord-353697-ocxextfj cord-353401-y1mxnth7 cord-355003-1o2midnh cord-354204-23xkug85 cord-353594-z1vxamvp cord-354373-lldfoptb cord-354658-v451z3jq cord-354619-pftjhtpo cord-353599-cw29edwr cord-354597-xubsodnk cord-354411-4emzxu09 cord-354194-hf5ndv5f cord-353824-0oyvia6d cord-354720-fu19u2b0 cord-354689-dsv63it1 cord-355028-1x7w1749 cord-354168-omen8vvq cord-354216-4khdcjed cord-355039-qi4fwqbc cord-354749-zkgb16ae cord-354337-a70avg2x cord-355264-ygzh8von cord-355294-gifsqph6 cord-355533-5kgdg2nb cord-355524-qx396wq1 cord-355146-6rat5j64 cord-355528-y4a1g6km cord-354824-7fdcu2f0 cord-355504-zsyvgm9c cord-355431-efwuy8p9 cord-355898-hlkwwaqe cord-355031-l0tj7kp2 cord-355033-txxylmrw cord-355885-pg6mpuk5 cord-355190-ytdw1d5v cord-355191-jghvq3cy cord-355484-2igc5wzx cord-355549-6xnjj5h5 cord-355384-qa7grviy cord-356040-qdpkidn8 cord-355177-62v1qhia cord-355558-r6r1t47c cord-355296-46jf56nc cord-356195-5pcaxpp9 cord-356371-w9ejgzvu cord-356127-xy5tyd7t cord-356215-0nypfw48 cord-356332-t0ahmh0h cord-356349-ey5vnddu cord-356084-621qzpqd cord-356379-e8ohc25w cord-356056-82bvcuvd cord-355589-3zdv9zim cord-356057-87kxlqdc cord-356246-4p0ok1mc cord-355038-o2hr5mox Creating transaction Updating wrd table ===== Reducing urls cord-000001-ug7v899j cord-002782-mena480g cord-000522-d498qj2b cord-004379-91a7sgir cord-002514-pp06m5xk cord-003520-f3jz59pt cord-002956-e5ihpe4i cord-004310-hl7fa4af cord-004147-9bcq3jnm cord-004342-9uok77wb cord-004404-s6udpwxq cord-003291-zuqx6ksy cord-000161-hxjxczyr cord-000904-g6ffaer1 cord-004636-t6qldq3s cord-004450-daxz9yhp cord-005496-cnwg4dnn cord-004646-zhessjqh cord-003011-vclnb0eh cord-003832-q1422ydi cord-004464-nml9kqiu cord-002626-jzwwses4 cord-004643-uu4uipfy cord-004339-7nwpic3d cord-004515-x22q1f21 cord-001221-due9tloa cord-005503-hm8tvkt3 cord-005606-c8c2rfzi cord-005147-mvoq9vln cord-005569-9d51l6bn cord-004894-75w35fkd cord-005480-yg7salqt cord-005478-5iu38pr6 cord-005705-j765ruj1 cord-005777-6rvfsx4p cord-006768-r2pa9qw0 cord-007009-4wbvdg1r cord-006975-u5ecibta cord-007818-jfp9uumb cord-007786-cu831tl7 cord-007788-09t52zix cord-007798-9ht7cqhu cord-006182-kck5e1ry cord-009891-gqrhbhbn cord-009360-rgwe2pkx cord-006854-o2e5na78 cord-009667-8r8j0h08 cord-011159-k2kca8zl cord-006849-vgjz74ts cord-010416-u0yo0lk6 cord-010564-7c9h16bi cord-011712-fyrbe8tw cord-011975-8vl45xb7 cord-009664-kb9fnbgy cord-010460-pczs9alv cord-010088-s9tfvtao cord-011512-gw2sk90q cord-010027-r0tl01kq cord-011255-9q2frk71 cord-011062-ukz4hnmy cord-012037-9kmul7he cord-012778-yr8zuvw9 cord-013149-y0dbhtef cord-012902-efprpk72 cord-011836-zib8wkm2 cord-013116-n7auvqh3 cord-012934-c6pbr64i cord-010980-sizuef1v cord-014980-cz1gx9oj cord-014533-6qfecv5h cord-016105-jkaxemmb cord-014996-p6q0f37c cord-014464-m5n250r2 cord-017569-fv88n70v cord-017772-zpf1xjqi cord-018110-mcw4v13c cord-018545-fk17n2bx cord-018595-x3tleomb cord-018590-rkp89dqo cord-021075-8hba6au3 cord-021905-fjcks7w4 cord-015359-gf32a6f1 cord-009997-oecpqf1j cord-023169-obupqcua cord-019490-m1cuuehi cord-023168-cd7adns8 cord-024233-hrzpxdh0 cord-023216-avn8f2w3 cord-024073-243addff cord-025157-7b3v5yct cord-023509-tvqpv6fp cord-027551-a92lv4sh cord-024833-e6vcf4un cord-026879-gwzrdeb1 cord-023913-pnjhi8cu cord-026392-cvb44v5v cord-026653-094bk0t0 cord-027678-k64whepc cord-027259-f4sgobcz cord-028709-r1inj3ra cord-028379-ghudhac6 cord-028590-rw0okd0p cord-029183-3aotgq6m cord-015354-yknwveyz cord-029112-u507i0t0 cord-021206-4zyqqgs0 cord-022501-9wnmdvg5 cord-029991-0sy417j0 cord-010092-uftc8inx cord-030370-89n13hml cord-030502-mvlib8ol cord-005460-ezrn8cva cord-023354-f2ciho6o cord-023346-8sqbqjm1 cord-031558-8wysernx cord-030962-2xem8inu cord-023364-ut56gczm cord-032544-2yrqjw1o cord-032392-ex3s8evv cord-031734-5wnvuk2n cord-034257-kl2ccmz5 cord-022888-dnsdg04n cord-033574-4y53ryoa cord-034371-j3xxmkjd cord-034340-3ksfpaf7 cord-034746-uxhpufnv cord-103686-er8llst4 cord-035067-ic843wr9 cord-035030-ig4nwtmi cord-048489-ajafw966 cord-035090-gnfeyddv cord-103214-3lz33pj3 cord-048343-nzk8m912 cord-102276-0a8hup5y cord-103807-x4hrwhkz cord-217201-lvefk7qx cord-216974-0al3vdh1 cord-138439-wvynetna cord-103659-wpwfqhp2 cord-252829-gn56tsz3 cord-252279-0gozdv43 cord-252368-njlo6g78 cord-252506-8u9oiqoc cord-252539-kx8ew3ap cord-225218-x32a4sp3 cord-252531-i3b647wv cord-253456-u9num2o9 cord-253638-5f9ofdsc cord-253129-v5lck9l7 cord-253417-ihi67m1u cord-252775-faxiem2w cord-254446-yxqbe1dj cord-253746-15w4gquq cord-254428-n0uwy77g cord-254040-s3k51rkk cord-005453-4057qib7 cord-255197-79yfslu1 cord-254419-qw83atrx cord-254382-xy8se56o cord-255746-ir73lpi8 cord-256109-dkp0fwe3 cord-255831-nrc35tug cord-256262-lwc4ghj2 cord-010119-t1x9gknd cord-255905-ti9b1etu cord-257274-fzyamd7v cord-257206-av2k44ig cord-256893-3sh87h2x cord-257717-fbfe5vt4 cord-257600-0plhquk9 cord-256864-v3mxcwru cord-258113-mnou31j3 cord-257467-b8o5ghvi cord-257781-ybpliz32 cord-258548-1u7v1nlr cord-257839-kfzc4pwq cord-256634-gg8hptfg cord-258093-6fn8ei9f cord-258117-5gpo8smn cord-258583-5qdthy0j cord-258576-ywbyflas cord-258498-0mvxwo3w cord-259747-sl9q63oc cord-031907-ilhr3iu5 cord-261485-0ke5nqy0 cord-261670-rd9uq6tc cord-022940-atbjwpo5 cord-261941-xf1k5uj1 cord-262708-hctuxrw9 cord-262467-epqqd8n8 cord-263292-qjfe2t9v cord-263241-qzerj9bs cord-263883-7ba0huwy cord-263882-s5oxr6es cord-263793-bmadusm6 cord-264673-67zopf7s cord-262766-ndn6iwre cord-263294-9r84f19u cord-264829-ynel6ore cord-265111-d44ireu5 cord-265230-ozyx8u64 cord-266010-ectnfv5z cord-265472-b1s4stvz cord-266214-l8pmhcd5 cord-266730-mio282vy cord-267357-7aap2cte cord-268561-vq1uhj5i cord-268540-wrjzr3ws cord-268617-1t7yaoct cord-268886-mpceglk1 cord-269087-f9hyntvf cord-269009-0i2bvt77 cord-269289-6uog10j4 cord-269554-fzu6dy4e cord-269690-6r2bfydw cord-269591-lu415jcp cord-270153-krhkqcev cord-270210-gfy2ytg5 cord-270388-nozh463l cord-269776-hj1s3ipp cord-270712-v6nnnzhm cord-271603-zy4l9vtf cord-270245-zziwb2jy cord-271220-sntawlnf cord-272419-y3ebt4jm cord-272677-6t9kl3hq cord-272778-aixiioii cord-273175-bao8xxe2 cord-273567-8fp3a9h8 cord-273283-gb0m6fue cord-273929-kpcmy9x8 cord-273587-nja58vxw cord-274184-hm516x6p cord-273758-hhd8xnve cord-274008-p3st70u3 cord-274481-k1dp1ilv cord-274282-hvx5m2bx cord-275041-fcdwitxy cord-274355-6hiutrct cord-274324-obhrbxu4 cord-274860-7ec2jcoq cord-275260-xuhxqkyj cord-275185-9br8lwma cord-275266-e6omvo5x cord-275214-mqvw0219 cord-275004-qzg03dvg cord-275340-q8d7rvnj cord-276132-tv5y1eqc cord-275440-fl4dsu7d cord-276264-wgzh3f5m cord-275979-cx2h5bsw cord-276405-yfvu83r9 cord-276495-q22jnkn2 cord-276782-3fpmatkb cord-276592-dsilwfl1 cord-276327-wyevh4xv cord-276641-40r4mitg cord-277207-2my86ums cord-275828-c6d6nk7x cord-277700-nxm1jr0x cord-277178-nbotxv35 cord-277210-xaj2623u cord-277811-j58qvyum cord-276758-k2imddzr cord-278300-6cr9h7no cord-278937-lkuuftno cord-278984-0zof6s4d cord-279052-8hxdfdls cord-278943-f80ucqqp cord-279158-dsnniuo6 cord-279111-jaa45kyc cord-279667-ikfduu2k cord-279483-gwikyux2 cord-280360-rh37d5wc cord-280821-kc0ut4oy cord-280431-tuzdng4h cord-280944-uphs5gvl cord-280358-ru2hv6pz cord-281039-a7q5nzwn cord-281175-og3myz22 cord-281106-vzb5xzza cord-281332-5mddyv0n cord-281346-bjhdy8mg cord-281561-r10y2sgb cord-281566-6v5zfue6 cord-282097-a1pwq4fi cord-281733-bsq0ewac cord-282589-xof56j98 cord-282535-gnuhjs32 cord-282724-zzkqb0u2 cord-283141-dh8j7lyl cord-282704-qg2o0ug4 cord-282780-34j7gquo cord-282956-f7if9e5q cord-283165-mdkr9qo0 cord-283215-dgysimh5 cord-283517-7gd0f06m cord-283583-pwlbrxn3 cord-284454-malfatni cord-284804-6i5zbmm1 cord-285414-vd2d7db2 cord-285755-zblitbo0 cord-285588-ug7upa3r cord-285867-61y4aamj cord-286683-mettlmhz cord-266105-8avkjc84 cord-286403-gdkwabcj cord-287102-o19uwryp cord-287544-n32iscmr cord-286334-d9v5xtx7 cord-287538-qbf5lv7d cord-287732-abzpfdcu cord-287957-diyz54qy cord-288040-uuqfvvmk cord-287742-y1j9x5ne cord-288067-36amafub cord-287991-10jz1dz2 cord-288580-onzzpkye cord-289064-435bp4rt cord-288810-ab7k70c4 cord-288606-h8pmqwmk cord-288051-wp8v2mc5 cord-289006-7dv1zsp9 cord-289542-u86ujtur cord-289054-fh95b5n4 cord-289719-64ugdvfe cord-289088-7uoia564 cord-289322-5ciaonf0 cord-289859-b1k9uyp6 cord-289533-hip9qtu5 cord-289806-6ihptx6n cord-289973-1mczuxsy cord-291686-kgewmqg5 cord-291025-u5z8zji3 cord-291417-p49ukyhx cord-291670-mqj071gp cord-292056-dtdyxhq4 cord-291566-jwlvustd cord-291697-wpnq9wc0 cord-291687-kwu0otpi cord-292561-iy06b9h9 cord-290832-zmj59rc3 cord-292620-t8ocqm6g cord-292394-91b3mm6c cord-292094-vmsdhccp cord-293730-dlqo6fep cord-294057-fbox3a5q cord-294487-hcuzxhb3 cord-294108-uvnh0s9r cord-294336-fqobpo47 cord-293472-d3iwlpsr cord-293922-knzv4jvj cord-294139-78c5h7la cord-295123-x2gxgave cord-294079-px9c20il cord-294527-fct2y5vn cord-294064-vdpak3fm cord-295514-vhymj0rw cord-295414-v10454ns cord-295144-tyyc81uc cord-296018-lgx5k2kp cord-296182-hhswage4 cord-296562-3h2oqb9k cord-296588-q2716lda cord-295703-no45mgyd cord-297127-nhgm09db cord-297093-ld89vmct cord-296936-5gkx4jxa cord-297836-y9vt6wvu cord-297138-t8b3914h cord-296773-5o4hr6ir cord-297518-6y2uzcde cord-298787-4vo9gpiu cord-299881-weptfpa2 cord-299750-zkrlm3ds cord-300608-eju7wnb9 cord-300445-qzu4gz2d cord-300303-d4qmtysd cord-301342-ikvpkhfp cord-301592-n5ns3m34 cord-301590-70qmpccs cord-301805-sb0ij8k7 cord-302459-grs2x26l cord-302316-raf5rlkq cord-302788-kg8zwysg cord-302576-fv2ib5vc cord-302382-eifh95zm cord-303145-rc5luali cord-302997-39o08tt1 cord-302821-b9ikg0xy cord-303192-il3s8lgp cord-303054-s1clwunc cord-303363-uu9hb1c9 cord-304010-n4gxxl5i cord-303483-wendrxee cord-304271-vyayyk50 cord-303703-ekhwb5xb cord-304573-3nhglbw4 cord-304474-hfv43e9m cord-304457-8g36h1bz cord-305134-s7h6bpof cord-304791-wv4qu9xm cord-305422-t8azymo7 cord-306266-8qdrshz3 cord-306062-g9hk1iq5 cord-306997-84pjfawk cord-306377-s9j21zsy cord-306896-khn8epxd cord-307690-1qqyixun cord-308010-ix0xi5jb cord-308075-1ftswsm8 cord-307309-s0t4kp2x cord-308195-nlibv0u4 cord-308313-3speddao cord-308906-et7duogt cord-309024-pu830bn9 cord-308803-i934doud cord-309194-jtouafgd cord-309370-g8d3w7it cord-309421-725u6dau cord-309323-yflng8m3 cord-309829-3dlfcy31 cord-310690-50z2kdaj cord-310974-hz37yf39 cord-311074-j3fw4dfc cord-310676-125o0o7x cord-311373-ngs7baoc cord-311682-npi03i7q cord-311970-o9xao5rl cord-312249-k7dp776s cord-312192-hxhohtmj cord-312677-rwznqiib cord-312572-i7r28wdc cord-312847-2cg3ylfl cord-312632-g4250q6l cord-312209-3yi1w44v cord-313294-ffgo56gl cord-313468-lloh1b0y cord-313529-xm76ae08 cord-313528-rp15vi1o cord-313894-stgx36h5 cord-313860-mzs3ya0s cord-314171-431buxxr cord-314280-kf2bo06e cord-314826-usfvulc2 cord-315397-cm3mc7we cord-315188-a9pvugjt cord-315181-emf4i6ir cord-315574-jq1p5t8w cord-315696-43wmazxa cord-315834-ashjw2xs cord-315871-anguylf1 cord-315157-2p45frlk cord-316083-f1h2j6jx cord-316370-t802kjpk cord-316845-k9zvsfvj cord-316616-j82q99in cord-316764-ps89rxuy cord-317151-cxx5pcln cord-317085-qc8bfb9g cord-317604-j8b64a1a cord-317811-mxsujb5u cord-317566-6ch6na31 cord-317809-umb8j63t cord-317932-5sqj2klm cord-318063-bainw3d6 cord-318021-4qrf5m8s cord-318694-370ccaoc cord-318333-rzhrgp5q cord-318954-pj5lsvsa cord-318803-xpa49sxt cord-319400-lghjiw5p cord-320349-6hbuq0k7 cord-320811-9sm7iz5x cord-320267-n21jryi2 cord-319805-b6ypt5d0 cord-321064-pe8466n1 cord-320572-94fvtj4a cord-319013-oytqcifa cord-319706-2e9jrv0s cord-320612-vam0bli3 cord-321543-qdmvn44h cord-321030-isc3p46t cord-321237-ynhdii60 cord-321788-z2y1ywdq cord-320930-9yiu0080 cord-322009-0cwljo0c cord-322534-eikz07zz cord-321697-yua3apfi cord-321472-n4nnmlv1 cord-321784-nubu5fuz cord-322054-whjisspt cord-322052-zsbisk3b cord-322322-woz6lwdu cord-322448-s04e6po9 cord-323024-blc3mnbj cord-323092-j2u0ny2u cord-323225-ou7pppum cord-323980-rcyjthze cord-324060-vvexfg1c cord-324601-s3rgxtg6 cord-325201-yoy7kdli cord-324619-y7gilopu cord-324529-xbrdtxnz cord-325234-skshcrh1 cord-324944-ixh3ykrc cord-324798-qh0cxp10 cord-325307-agaau27o cord-323940-ubazgvov cord-325421-1ysn0kyr cord-325783-pqonn0as cord-325649-zzhsrytw cord-325631-c7jwizpj cord-325700-f102uk2m cord-326468-xcy7v1tf cord-326017-qw4qynqv cord-326851-0jxdnm1l cord-326883-j7pbe50g cord-327397-8rxjju0t cord-327349-rxb6zfoc cord-327481-m9r0p84v cord-328040-5qd05e4r cord-327961-ysatxwph cord-327818-1abweqko cord-328484-4iptwc3n cord-328384-jzfr2t3p cord-328829-yywxmioq cord-328895-p75b7jii cord-328113-eczjjc2v cord-329152-1ixylnny cord-329564-tmi1u224 cord-328289-3h3kmjlz cord-329453-ry1diso2 cord-329863-r2vqsg5r cord-329727-h47q76y8 cord-329877-vish6v8e cord-330666-puhijixa cord-329856-0m5mc320 cord-330369-75cotmn2 cord-330573-rr2r8245 cord-331114-lumfg138 cord-329766-9bwdb6o2 cord-331270-12zx0o2p cord-331481-zeaqi1uc cord-330870-l0ryikhv cord-331533-0toegbv8 cord-333340-ekok0mp5 cord-331519-ye4dtna5 cord-331487-jh34klbg cord-332150-j76726no cord-332278-2p64ab2z cord-333113-0k6xlmem cord-334367-w96iqo6q cord-332180-dw4h69tp cord-332788-8lq9qygn cord-332480-3uodkrkp cord-333024-1yrmun3z cord-334408-w0yxz7zb cord-332992-8rmqg4rf cord-335597-anrzcsrt cord-334881-x9nxxled cord-335312-yp73z008 cord-335576-b34nc3ay cord-335593-cjb0daps cord-335095-epsi5qq7 cord-335719-tnimrff9 cord-335141-ag3j8obh cord-336368-sudi4mdx cord-336000-v88bq4bx cord-336201-fl606l3b cord-336790-29im4gxw cord-336438-mlgxiyur cord-337115-vtjsigod cord-337120-irpm5g7g cord-337010-dgy7qbl5 cord-336782-0zkb39v1 cord-336563-hwemigk7 cord-337302-fpz2jfuj cord-337297-fkw8780t cord-336810-77wq9laa cord-336784-24qizp9k cord-338192-2v9dbc9h cord-338683-nzgnpi6f cord-339406-81a7fkpj cord-339467-ewqxf02j cord-339266-glmshsh6 cord-339436-0k73tlna cord-339737-7qdjea6f cord-339474-tsdq1rgz cord-340164-vzdyy656 cord-340880-2qop8tcp cord-340253-lpner9f8 cord-340650-mwsa326c cord-342303-ddulfe06 cord-343052-dc9s2rau cord-343201-98scxky8 cord-342519-tjr6dvtt cord-341314-1mav631s cord-341234-2zgfcrwc cord-342569-ja96xfns cord-341076-ox2ckhqu cord-342809-wrxejwms cord-343452-4m0ub9iv cord-344004-z7pn7u6u cord-344135-pyibu6rj cord-343566-epvswt7f cord-344431-2wq7msqz cord-345628-a4c46m2w cord-344017-qldawc8m cord-344693-znw3dru4 cord-345632-iha2c5zo cord-345611-xv62h83a cord-345680-10phij1x cord-345371-pjbviagq cord-345092-1ztfcpsb cord-346061-pbghgitg cord-346345-jc9bq0zu cord-346015-bzeqs5oh cord-346894-iy35298o cord-347058-kejcwlng cord-347289-3yi5tz04 cord-347121-5drl3xas cord-347697-uz0i6wfp cord-348501-8cvtqj7w cord-348672-e34103b1 cord-348172-q3zcn5pf cord-348975-plne3xlz cord-348813-v1sdodz9 cord-348578-chfb4i15 cord-348130-t9tysvr8 cord-348755-2g5gi1du cord-347263-ci6mv72z cord-349329-f0pbd968 cord-349500-603v8lfb cord-349533-51cex2sl cord-350437-dq1il88y cord-350179-ltk5hfc4 cord-348535-tvs1snq8 cord-350408-rqlkwoya cord-350990-tywbe4o2 cord-351224-jeedo5mc cord-350200-1w5u3w8i cord-351184-kcc3p3ow cord-351340-7y19ystp cord-351825-fdog73g2 cord-350639-iguadmw1 cord-352193-izzqdg3v cord-351531-wo1ggmmn cord-351604-x4rsdwqz cord-351722-3mw1te94 cord-352234-utjne1ef cord-351823-ldbscq4s cord-352177-05sku8a8 cord-352302-are8vvhh cord-351431-xcqz9d3t cord-352227-827987jf cord-352579-ndcbmgfj cord-352969-rpt7xja6 cord-353059-39msyuxb cord-352905-ge3u32hm cord-353484-q7d0ysbo cord-353200-5csewb1k cord-350571-6tapkjb6 cord-353648-rl9dts7l cord-353671-xjpzhsup cord-353987-hj94a04i cord-353594-z1vxamvp cord-353340-l0icku0i cord-354168-omen8vvq cord-355549-6xnjj5h5 cord-355484-2igc5wzx cord-356332-t0ahmh0h cord-356127-xy5tyd7t cord-356349-ey5vnddu cord-355589-3zdv9zim cord-355898-hlkwwaqe Creating transaction Updating url table ===== Reducing named entities cord-000001-ug7v899j cord-001313-f72hl6du cord-000831-zwfxnd7r cord-000308-cxr1ul7q cord-002782-mena480g cord-000229-9fr0m92p cord-002977-o0dvwzxk cord-000716-fhm8abxp cord-000284-00rk8fb5 cord-000522-d498qj2b cord-003533-8m0vyxq8 cord-002240-38aabxh1 cord-004379-91a7sgir cord-002514-pp06m5xk cord-001421-6t5puo6p cord-000457-e50a0suk cord-002294-qa8e90qv cord-001322-7xmxcm35 cord-004986-en7taikk cord-003828-bhfghcby cord-001617-ff3j7i7i cord-003404-eqgc8v7y cord-003520-f3jz59pt cord-001661-dj9bxhwb cord-003701-i70ztypg cord-004310-hl7fa4af cord-002956-e5ihpe4i cord-004147-9bcq3jnm cord-004342-9uok77wb cord-001879-bn7h0kcw cord-004314-gtwtakpr cord-004404-s6udpwxq cord-004096-obrq7q57 cord-003291-zuqx6ksy cord-001154-7k59ogn0 cord-002757-upwe0cpj cord-003798-nki2sasr cord-002774-tpqsjjet cord-000161-hxjxczyr cord-001078-5m29nugu cord-001493-3yu2di1g cord-000904-g6ffaer1 cord-000891-5r2in1gw cord-003219-iryb3v0z cord-004636-t6qldq3s cord-000268-480d3yfv cord-002145-yq7iwp42 cord-004450-daxz9yhp cord-001293-dfaxj3bv cord-003686-1pfk4qve cord-003198-1kw5v6rm cord-004532-flo9139j cord-005496-cnwg4dnn cord-005482-v5iayczy cord-005425-0hxow3sj cord-003011-vclnb0eh cord-004646-zhessjqh cord-003446-yp5d29fk cord-002853-vj8t28hn cord-001536-ta1i0ata cord-004464-nml9kqiu cord-003376-2qi4aibx cord-003832-q1422ydi cord-004263-m1ujhhsc cord-004186-m817oudw cord-003615-vpzzsdld cord-002626-jzwwses4 cord-002724-gtv9syzi cord-004339-7nwpic3d cord-004643-uu4uipfy cord-005420-60ie0pfd cord-000843-e1bn79ui cord-004515-x22q1f21 cord-004949-icsey27p cord-005503-hm8tvkt3 cord-005481-00rezmqj cord-005452-ouookpd8 cord-005606-c8c2rfzi cord-005569-9d51l6bn cord-005587-8iwsvku9 cord-001221-due9tloa cord-006179-7uv4yfv2 cord-005697-l1zmrq4p cord-005705-j765ruj1 cord-005819-fp5khzd5 cord-003532-lcgeingz cord-006181-fkh2fzbr cord-005861-3k8h3euj cord-005487-vac061r8 cord-005646-xhx9pzhj cord-004894-75w35fkd cord-005147-mvoq9vln cord-005480-yg7salqt cord-005992-mu917isy cord-006544-yr4u61qv cord-006302-pnnkfid0 cord-005717-x7gsqlwp cord-005478-5iu38pr6 cord-005692-n4vxazst cord-006841-3u56erru cord-004675-n8mlxe7p cord-006545-c12m75gq cord-006518-al94gxjw cord-006332-ikh45wuy cord-006236-2gpwf4z2 cord-005795-sgi54hq8 cord-006679-nhbofufv cord-006750-cg2i2bae cord-005808-w0763esk cord-006394-ucthbqvt cord-005750-54hul2lw cord-005105-twsy61oq cord-006621-0fxpn7qf cord-006523-zxn4oqly cord-006343-c0amee70 cord-006391-esnsa4u5 cord-006000-ekwpkzqv cord-005953-5z89yeb6 cord-006563-qmigctkp cord-006226-fn7zlutj cord-006344-de4dhv4b cord-006701-q8qh1kas cord-006426-baf2d47y cord-006363-xov4xwpa cord-005816-i54q5gsu cord-006714-q7wy76e2 cord-006508-rje9bnph cord-006856-b1w25ob5 cord-005497-w81ysjf9 cord-005777-6rvfsx4p cord-006517-845w9r6l cord-006464-s8rjoyse cord-007575-5ekgabx5 cord-006768-r2pa9qw0 cord-007567-vst954ef cord-006444-eq56zhtd cord-006595-brpngt14 cord-007444-c9vu8ako cord-006862-5va1yyit cord-006864-t5qsjyfi cord-006460-3ayc0hne cord-007321-7gi6xrci cord-007009-4wbvdg1r cord-007564-ljqrxjvv cord-006702-ekf6mja9 cord-006869-g2q1gpp0 cord-006828-i88on326 cord-007563-33jxxp1b cord-005881-oswgjaxz cord-006975-u5ecibta cord-006882-t9w1cdr4 cord-006924-1i3kf01j cord-007818-jfp9uumb cord-006888-qfnukav4 cord-007786-cu831tl7 cord-007833-wkv808ix cord-007580-qwh8ei60 cord-008672-luoxomif cord-007696-83v9yfa6 cord-000083-3p81yr4n cord-007865-1oyl6clq cord-007788-09t52zix cord-006876-v2m5l5wz cord-007798-9ht7cqhu cord-008596-zhk82cor cord-009417-458rrhcm cord-009278-98ebmd33 cord-009285-1ddfywfa cord-008695-y7il3hyb cord-006880-9dgmdtj8 cord-009360-rgwe2pkx cord-009891-gqrhbhbn cord-010116-hfzs16jh cord-006182-kck5e1ry cord-005727-li8pwigg cord-000718-7whai7nr cord-000977-ka4261wc cord-007577-f1jzbtjj cord-009322-7l7slziv cord-009507-l74c9x0n cord-010487-wncgecld cord-010078-8lkkez3n cord-010856-3g0123lk cord-009512-o4y9s8zf cord-009667-8r8j0h08 cord-010658-67k8pthy cord-010261-sy7esszi cord-009571-mygj2nd4 cord-010999-u2guhh3h cord-011138-y9v5ivzg cord-009697-dq4y89ab cord-010844-y26y5myb cord-010477-g754gjvh cord-011159-k2kca8zl cord-006854-o2e5na78 cord-006860-a3b8hyyr cord-009713-sxd4t2tz cord-006466-e1phpqes cord-009575-bd67ph64 cord-009788-bc6sc2rc cord-009982-zgbu46fo cord-010036-6czkzek0 cord-010929-d598h08w cord-010141-955r29sd cord-010416-u0yo0lk6 cord-010461-un9pls28 cord-009967-fyqc5bat cord-006870-f5w6fw6q cord-010564-7c9h16bi cord-010786-w3kjc6so cord-010398-5wot7tix cord-010075-72jodunj cord-010460-pczs9alv cord-009664-kb9fnbgy cord-011093-d9dbvbcy cord-010921-yzv43e8l cord-011533-im78xwl8 cord-010566-tciwtxud cord-011360-1n998win cord-011413-yv4x8viu cord-006849-vgjz74ts cord-010027-r0tl01kq cord-011296-nutl2ovk cord-011181-9nvwk04v cord-011284-u4qmvz3c cord-011255-9q2frk71 cord-011725-t1jl4cy1 cord-011712-fyrbe8tw cord-011349-bykvn367 cord-011483-zc6ve6le cord-011297-4um9w2dx cord-011975-8vl45xb7 cord-010088-s9tfvtao cord-011512-gw2sk90q cord-012025-faj682bp cord-011649-3dlsy8fl cord-012117-c693oefo cord-011221-rhyxp4v5 cord-012115-hpsxi9ay cord-011188-59hn9wsv cord-011793-hlktpla4 cord-010933-xuztu95a cord-011103-sstpidvk cord-012459-tge08va0 cord-012037-9kmul7he cord-011302-pfepyvaw cord-011327-zsoc4wec cord-012665-fflye8a3 cord-012778-yr8zuvw9 cord-011062-ukz4hnmy cord-011875-ga0dzj3v cord-013035-7sfj0czv cord-013149-y0dbhtef cord-012469-6cvu5umd cord-012902-efprpk72 cord-013003-gxd29jxf cord-011836-zib8wkm2 cord-013116-n7auvqh3 cord-013139-b32xg7y7 cord-013370-gktnz644 cord-013105-tmhce7p5 cord-012934-c6pbr64i cord-013148-qbxbndsl cord-012518-ncrdwtdg cord-012560-p5s0p7fd cord-013589-3l8kar3k cord-014833-ax09x6gk cord-013457-rqon1adg cord-014540-27hnlu5v cord-013380-1jwzbgwb cord-014538-6a2pviol cord-014712-5u4e00q6 cord-015090-n6f4xupw cord-013558-0sa63lp3 cord-014670-e31g8lns cord-007890-bie1veti cord-014933-3jezc081 cord-015082-l629n8is cord-015335-l0kjxhd1 cord-014965-efmozngq cord-015162-6be21d59 cord-015389-vwgai4k9 cord-014980-cz1gx9oj cord-015930-18qznqp0 cord-014987-nycbjqn6 cord-014533-6qfecv5h cord-016280-d47e3art cord-015365-iqdi99pd cord-015334-8p124rwp cord-010980-sizuef1v cord-015569-vy49r1zd cord-016237-sk1wzghx cord-016248-dxk0i6t7 cord-015946-biu5zxd1 cord-016211-8j8n9enn cord-015348-qt0worsl cord-016301-vqmqnipq cord-016110-mlwe7fzz cord-015922-5wwy0m2k cord-015884-mtpbzgr9 cord-016208-u12ngkpc cord-016135-44pgjah8 cord-015126-cyhcbk1j cord-015640-zdwmxaz3 cord-014976-546zaoxn cord-016498-j72vrvqf cord-014687-0am4l5ms cord-016601-gp259urb cord-015372-76xvzvdg cord-016127-tbot0fc9 cord-016177-fz48wydz cord-005814-ak5pq312 cord-016105-jkaxemmb cord-016372-opojt70e cord-016460-39yniw0t cord-016413-lvb79oxo cord-016235-2lhrkmrv cord-015370-4jfgsic7 cord-016871-1mlamf20 cord-016300-vw11c2wt cord-016572-6fu5s89c cord-016308-qzkcwrit cord-017012-yl0vanuh cord-015024-2xzc0uc5 cord-016814-tf17dpo5 cord-017105-mljywm9p cord-016521-ouwwkxox cord-017252-88b3preq cord-016757-3d320c0a cord-015368-a0qz4tb9 cord-016559-tqd7m2i1 cord-014996-p6q0f37c cord-016973-s32jp0ej cord-016476-78r0rsio cord-017227-66dx2dkv cord-016478-gpl0zbvd cord-017040-4zajnrsf cord-016960-xhzvp35g cord-014464-m5n250r2 cord-016982-qt25tp6t cord-017217-zjab7o2o cord-017142-vx3rgs4r cord-017350-rwqaw5ii cord-015369-72cjogxz cord-015352-2d02eq3y cord-017309-pt27efu1 cord-017302-xez0zso3 cord-017016-twwa9djm cord-017324-l3d3t4wh cord-017374-clctlm5l cord-017337-vq3edhxn cord-017392-ja9b5vy9 cord-017531-fm8gl5b3 cord-017489-ftz9190a cord-017420-tjwxec77 cord-017393-kx8kmdej cord-017534-0ai8chbu cord-017518-u2gsa4lg cord-017569-fv88n70v cord-017184-1ewi3dka cord-017516-qbksb83c cord-015306-us58wwmp cord-017772-zpf1xjqi cord-017461-xw02c7u5 cord-017715-99ri6x0y cord-017581-6lubp7io cord-017617-13m7pmvq cord-017883-6a4fkd5v cord-009567-osstpum6 cord-017897-mbwm0ytg cord-017862-9fkjjmvf cord-017815-0t7jvvz5 cord-017784-4r3fpmlb cord-018182-lleti89n cord-018005-53cl75gk cord-017946-fa4ehlb0 cord-018209-v2crgj5w cord-017799-2nvrakbs cord-018110-mcw4v13c cord-018106-5giapmcf cord-017786-kfl6xt31 cord-018363-qr1pk78u cord-018318-vzzrsqsn cord-018243-hyvu9nuq cord-018303-dvuwhpyq cord-018414-6ffhm895 cord-018408-ttae193b cord-018545-fk17n2bx cord-018590-rkp89dqo cord-018412-kv3vxmcw cord-018225-dozmy3lb cord-018447-z4jyjczy cord-018454-sy21cpff cord-018620-3kqx8arn cord-018430-u3k8pds6 cord-018623-of9vx7og cord-018601-mk66097y cord-018595-x3tleomb cord-018801-amet0wx4 cord-018638-4pyjhpbk cord-018780-zeok60hn cord-018714-i291z2ju cord-018809-3nrvm4jt cord-018834-4ligp4ak cord-018907-c84t1bo5 cord-019046-q6uv2ayi cord-014794-yppi30a0 cord-019010-9xgwjvsv cord-019027-6chba2ru cord-019043-cqmqwl3i cord-019968-o5bdb37q cord-019064-e5z92vg8 cord-021713-e0hzcag6 cord-021721-80pp1ra4 cord-019964-9leljj8j cord-018840-ts2g1ux7 cord-019063-mcxbl8mv cord-020342-u8jzmloq cord-021075-8hba6au3 cord-021742-sdz6d1r5 cord-021701-yan5q2r7 cord-022050-h24f0fpd cord-021917-z9wpjr0d cord-021816-gk8rwyq4 cord-022292-msz4au4b cord-022119-bzd9e1q6 cord-021571-7kbq0v9w cord-021905-fjcks7w4 cord-022103-4zk8i6qb cord-022646-f7qs1obg cord-022521-r72jtoso cord-022173-kb6mez61 cord-023169-obupqcua cord-022658-mq91h15t cord-022216-k4pi30sd cord-023622-tul7bonh cord-022594-fx044gcd cord-023483-owgs4syo cord-023288-sqr33y72 cord-015021-pol2qm74 cord-022527-a0x6lws3 cord-015359-gf32a6f1 cord-023168-cd7adns8 cord-022659-chwk2bs4 cord-023303-fxus38mp cord-023302-p9pxz44a cord-023033-tgt69ir6 cord-023311-7wqdlha4 cord-019490-m1cuuehi cord-023669-3ataw6gy cord-023186-gqltd6u0 cord-024233-hrzpxdh0 cord-023216-avn8f2w3 cord-023308-af5nihyi cord-023873-fidpskcs cord-023314-rwjxk8v4 cord-023729-dipjubn7 cord-023305-5lb9kho6 cord-023306-3gdfo6vd cord-023343-y17z9w2x cord-024130-kgzegwon cord-023298-ysur3sjq cord-024614-6bu3zo01 cord-023333-b7w9zrl6 cord-023331-jrvmgnu3 cord-024120-3eemj37r cord-024956-oht0v33s cord-024073-243addff cord-009997-oecpqf1j cord-023017-k6edtg58 cord-024893-pd67o7l8 cord-023509-tvqpv6fp cord-024795-xa7ke70d cord-023833-xpfibjh2 cord-025157-7b3v5yct cord-022653-qa1uph35 cord-023239-06a03o14 cord-025749-mip9mkef cord-024189-t7mbsr25 cord-027551-a92lv4sh cord-025666-u8w4sk07 cord-025172-qg3jxgch cord-027805-p0bhju1s cord-025990-nj4ah2yz cord-024833-e6vcf4un cord-025170-dtbm4ue1 cord-026846-3u3x52f8 cord-025176-f0frlpwh cord-025164-hqj22yxe cord-019347-tj3ye1mx cord-026879-gwzrdeb1 cord-027266-jdti1pwa cord-023913-pnjhi8cu cord-026392-cvb44v5v cord-026653-094bk0t0 cord-026991-75sbxnsc cord-026025-xqj877en cord-026868-z9gozm2w cord-028328-5lews3uw cord-028557-68jypaaw cord-027860-s97hdhh6 cord-027678-k64whepc cord-027259-f4sgobcz cord-028260-mja2jrgm cord-028709-r1inj3ra cord-028285-n4dommet cord-028907-m9psxg1f cord-027677-fc410vto cord-028379-ghudhac6 cord-028982-kkzpqbry cord-028590-rw0okd0p cord-029183-3aotgq6m cord-029211-6o7qn2y2 cord-029466-9sy6icrm cord-029606-2z1tw4xo cord-029112-u507i0t0 cord-022633-fr55uod6 cord-029626-j6b59y7a cord-029612-cts1al9z cord-029609-zh2ah34g cord-029770-72ncfyc5 cord-029615-x498xj3m cord-029848-dj5xqlz1 cord-029547-9ei1ram3 cord-029859-fhm0d9t9 cord-030256-muah207b cord-029991-0sy417j0 cord-030254-eevqclsy cord-031130-xvkyt3l3 cord-029332-yn603pvb cord-031544-clzt6kyg cord-023592-w96h4rir cord-021206-4zyqqgs0 cord-029884-zl0uqmfi cord-030927-wo8r8zny cord-022650-phsr10jp cord-029150-e242o2ml cord-015354-yknwveyz cord-030370-89n13hml cord-030918-0w327dgj cord-030502-mvlib8ol cord-028721-x6f26ahr cord-026031-hnf5vayd cord-030531-4uucx9ss cord-031129-wqkdug42 cord-030149-hkpjnqm9 cord-030369-4dn02a35 cord-030897-c88tjrai cord-022501-9wnmdvg5 cord-032588-8bfl2qy1 cord-032335-6c9gt7t9 cord-033279-bcf9568a cord-031710-1xl2isee cord-021087-n4epxwn9 cord-030216-l38i06v2 cord-023346-8sqbqjm1 cord-030380-okue1kso cord-031558-8wysernx cord-023354-f2ciho6o cord-031256-4mxt501d cord-030962-2xem8inu cord-034157-uif9xtvl cord-024651-578c9ut5 cord-010092-uftc8inx cord-030361-0tepkjdl cord-032928-m0awip9y cord-032544-2yrqjw1o cord-033247-2cbslnb7 cord-033135-cxsmxk3b cord-033965-c1i7dnnt cord-032392-ex3s8evv cord-031734-5wnvuk2n cord-031821-rywdkqcd cord-031191-63xtga7h cord-023364-ut56gczm cord-023049-fio7cjj5 cord-033778-u2r0neyc cord-034257-kl2ccmz5 cord-033574-4y53ryoa cord-034036-1wigu3i3 cord-033327-yi1tvsh4 cord-031497-pp0p3en6 cord-032930-ohsh46l2 cord-034286-m1c98nv7 cord-023157-0lqlx2rv cord-034185-e0am7pa6 cord-032183-yqqqe325 cord-033019-4eo037jp cord-034435-yp0gfl47 cord-034303-kcu9guxa cord-034371-j3xxmkjd cord-034690-x8lkngra cord-032244-s7t5u9lf cord-034340-3ksfpaf7 cord-034746-uxhpufnv cord-103686-er8llst4 cord-034898-zjfhpum2 cord-035024-kx9jfssi cord-035067-ic843wr9 cord-032181-gmcugd8h cord-035030-ig4nwtmi cord-048489-ajafw966 cord-034578-i9rdubix cord-035316-l4qbiuuu cord-035026-2qcsfd87 cord-035070-drt6esrk cord-104055-47ren7ie cord-035090-gnfeyddv cord-005460-ezrn8cva cord-102199-mc6zruyx cord-103214-3lz33pj3 cord-102276-0a8hup5y cord-048343-nzk8m912 cord-104180-f3hoz9bu cord-015324-y44sfr0c cord-035182-ax6v3ak5 cord-104507-xx7t26rl cord-035315-j5mknuv5 cord-184194-zdxebonv cord-214006-0w6bqrox cord-022888-dnsdg04n cord-103807-x4hrwhkz cord-217201-lvefk7qx cord-104467-elwfz1gk cord-035396-lg7m9xzs cord-148109-ql1tthyr cord-244388-dxrrpxl7 cord-158252-l43ztxsl cord-204125-fvd6d44c cord-216974-0al3vdh1 cord-103659-wpwfqhp2 cord-252159-6t35bxwv cord-252617-rqm0p19e cord-138439-wvynetna cord-252829-gn56tsz3 cord-252473-i4pmux28 cord-252374-obl6pfpf cord-252013-ehyuflg3 cord-251957-luw8m3eq cord-252368-njlo6g78 cord-252506-8u9oiqoc cord-252279-0gozdv43 cord-252284-cgdcsazr cord-252539-kx8ew3ap cord-252288-klkoerfn cord-252101-77lnyjan cord-252687-7084pfqm cord-225218-x32a4sp3 cord-252060-cotsu82v cord-252452-wwkw1uyi cord-104404-ytszpa4c cord-252531-i3b647wv cord-252085-8dq3gdo8 cord-252699-0xw9xvox cord-253456-u9num2o9 cord-253168-b095rq5i cord-252243-ua2w6xki cord-253148-3t4o27xp cord-252751-prock3co cord-254148-wc762p6v cord-252890-of29g89s cord-252981-hywvmdjb cord-253638-5f9ofdsc cord-254269-x8vpnhd2 cord-253886-4b3i30hi cord-253256-909chgl0 cord-253129-v5lck9l7 cord-253417-ihi67m1u cord-253375-m3qjj7r4 cord-253077-61fmul8c cord-254072-evgw0as5 cord-253189-uba6dy08 cord-253862-jl1zhg13 cord-253962-ug7yflxh cord-252775-faxiem2w cord-253704-y0t30xw3 cord-253295-82ydczid cord-254446-yxqbe1dj cord-253402-6sgeraws cord-253746-15w4gquq cord-253970-sbj869yy cord-254428-n0uwy77g cord-254478-scc9wee0 cord-254040-s3k51rkk cord-253730-cdkzvfib cord-254990-nrzwn6oz cord-255233-rvgj6pvk cord-255197-79yfslu1 cord-254025-j1l0mder cord-254993-bndl93qr cord-254357-5s84kimn cord-254852-qr5gdmbc cord-255256-8uckmya4 cord-255300-btyth32l cord-254419-qw83atrx cord-255267-o8k5ep9y cord-255490-gyq6cpc9 cord-255240-ltatgq3e cord-254382-xy8se56o cord-255393-aknebauo cord-254377-j8e8gb0l cord-254777-h8hw4m9f cord-255746-ir73lpi8 cord-254595-by2j7byz cord-255519-tcobane8 cord-256109-dkp0fwe3 cord-255831-nrc35tug cord-256011-0cr4ejxu cord-256262-lwc4ghj2 cord-254494-wbfgrez1 cord-256051-87alqfkd cord-255435-mr239gai cord-255037-i9guxtix cord-256459-6h358si5 cord-255807-7goz1agp cord-255460-r5p5helx cord-256030-5xzuilc1 cord-256290-pyrmtps3 cord-256117-t9v1hng5 cord-256888-tdx12ccj cord-256618-tt3p0tki cord-257035-ob1xncbs cord-256508-ce59ovan cord-255805-wlr8nod3 cord-256535-fz5p2u6p cord-255652-3n2dxljj cord-255905-ti9b1etu cord-257274-fzyamd7v cord-256556-1zea3wa1 cord-257206-av2k44ig cord-256849-8w2avwo2 cord-256639-4e0irb6d cord-257504-tqzvdssb cord-256893-3sh87h2x cord-257147-i48qljv6 cord-256856-jw1d6uig cord-257276-h5542vqg cord-257884-5exwwxin cord-257717-fbfe5vt4 cord-257600-0plhquk9 cord-258027-f3rr5el1 cord-256864-v3mxcwru cord-258113-mnou31j3 cord-257344-d13at1y5 cord-256688-yy7abob9 cord-257051-ntnfu5ns cord-005453-4057qib7 cord-258293-7q9zj8c2 cord-258067-par61wwh cord-257408-ejhhk1iu cord-257467-b8o5ghvi cord-257781-ybpliz32 cord-023211-kt5gt26t cord-010119-t1x9gknd cord-258278-25rhf91v cord-258548-1u7v1nlr cord-256634-gg8hptfg cord-257839-kfzc4pwq cord-258416-1jrbu8ox cord-257732-3xuy6tbn cord-257336-rpx71ww5 cord-257309-sazs5wgh cord-257433-qgkwylmk cord-257729-s0vo7dlk cord-258093-6fn8ei9f cord-258117-5gpo8smn cord-258727-mhg56j20 cord-258583-5qdthy0j cord-258708-da6x5rxa cord-258576-ywbyflas cord-258692-dch1utis cord-258888-amimzjee cord-257696-ybu772zw cord-258402-9s57thvn cord-258315-yt1ytasw cord-258758-sz8chn5e cord-259801-xuvcrvo2 cord-258133-zsweppku cord-259229-e8m8m4ut cord-258128-qtmjgrml cord-259448-deya8dwn cord-258930-60yn4hg7 cord-258498-0mvxwo3w cord-258916-jbdz1pk0 cord-259699-48jg7ci7 cord-259204-27t269pd cord-259767-x9s8qprc cord-259984-csdf1a69 cord-260105-ckh8jp9e cord-260456-kjmab3og cord-260503-yq4dtf8n cord-259747-sl9q63oc cord-259969-q65k590s cord-259073-dixskemz cord-259907-yqmi0cqy cord-260215-gsnjlhjd cord-260525-bohv78hi cord-259585-mjtxiu0t cord-259329-8pta6o6a cord-260037-ys62jrgw cord-260083-c1r9zn43 cord-260180-kojb8efv cord-259411-434acu0h cord-260630-vvpzp73r cord-260700-u12aa739 cord-260274-c3586tp6 cord-261062-9zhe3ejy cord-260232-98gtlad6 cord-260679-tm1s6wvj cord-260605-smkr7b15 cord-261006-2xh3f07i cord-260762-1kuj5dzz cord-260224-1aeqe7fh cord-260980-tyf3fuz9 cord-260981-647wfa8z cord-260871-dtn5t8ka cord-259848-0thzmh7k cord-261151-27ocvgnw cord-261410-kb91eagd cord-260854-v7wgb6mr cord-261383-izd1vn6f cord-261470-sqxdwu6j cord-260119-pgu2crhs cord-261485-0ke5nqy0 cord-261801-va2e029z cord-261025-y49su5uc cord-261311-j6bmgmhz cord-261246-m40kwgcg cord-261380-xms5su6w cord-260857-oxxle915 cord-261980-bm0benu2 cord-261670-rd9uq6tc cord-261921-c97ygxq2 cord-261240-osbk041e cord-261736-jlwctmxw cord-261856-i1e0uj0s cord-262412-bs7quwov cord-261455-uejtwgar cord-262236-1lilrqts cord-262068-9ixq8hwb cord-262454-bccrvapy cord-262339-e2ayh108 cord-262626-yk4e737w cord-262150-j72jbohi cord-262824-xgf5v1ok cord-261941-xf1k5uj1 cord-262796-syu4wbpi cord-262780-ilu5oskk cord-262708-hctuxrw9 cord-262729-qcijsyo6 cord-262467-epqqd8n8 cord-262954-saqo900k cord-031907-ilhr3iu5 cord-262518-a2ql8hib cord-262551-hxhlhb5m cord-262928-l2bqcd0l cord-262973-mydn7ver cord-262784-r9gq2oan cord-263061-ocplcdiv cord-262987-7h91n9ro cord-262998-cugd2t1l cord-263055-4f25h9l4 cord-263292-qjfe2t9v cord-263285-89zqgqx1 cord-263214-h6lkvlj3 cord-263064-n4c0m5hn cord-263716-ywsm11aw cord-262878-ygvbqmxd cord-263046-3aerbonz cord-263031-cco2vh0f cord-263599-cqol8zf2 cord-263691-ovsi38bx cord-263191-osa3ylkl cord-263530-t9ryky6f cord-263883-7ba0huwy cord-263241-qzerj9bs cord-263882-s5oxr6es cord-264327-uzlavmhx cord-263066-umvojci8 cord-264073-yhztrscf cord-264180-0vd3tr9j cord-263793-bmadusm6 cord-264122-n64tm6qr cord-263908-4ti8l2ea cord-264368-p2fwuh0i cord-264751-2l3cqhe2 cord-264647-9r443j3l cord-264673-67zopf7s cord-263628-ac9gld5l cord-262766-ndn6iwre cord-022940-atbjwpo5 cord-264295-7ojvhwb0 cord-264449-p3tgjuj4 cord-264042-4hc2i25r cord-264504-nnvof29x cord-264889-1vsvcza2 cord-263294-9r84f19u cord-264829-ynel6ore cord-264543-b4zwinh2 cord-264843-cwtdkylo cord-265052-hfuvm1oh cord-265799-qda5awuc cord-264779-71s7e18i cord-265053-x70501t3 cord-264972-hrbo3awj cord-265082-gjbabh4g cord-265721-wmz3wywi cord-265111-d44ireu5 cord-264924-ds6jv5ek cord-265278-wf5pbvvt cord-264952-0t0t4x0y cord-265098-u5qssib9 cord-264610-kxebc12r cord-265230-ozyx8u64 cord-265818-wme1360n cord-265812-1hcp36cw cord-265967-y4639p9m cord-265022-p5cab562 cord-266010-ectnfv5z cord-265934-wjdxqj8h cord-265848-afkeuwup cord-266456-10tjzqep cord-265472-b1s4stvz cord-265262-r01u4jr6 cord-266255-898h9rl1 cord-266294-ua22udlc cord-266079-nv28ppft cord-266469-n484zqq1 cord-266583-avhiqlgy cord-266214-l8pmhcd5 cord-266463-ci0g1dno cord-266429-0xaz8kbs cord-266722-qfn2dc1q cord-266775-4npowkkz cord-266450-g9vihgbk cord-266160-464v4g8o cord-266730-mio282vy cord-266478-642m488a cord-266750-41gth6o0 cord-266455-rbblg4pu cord-266475-t04pukea cord-266905-j9ljwqv0 cord-266744-31p212aq cord-267142-ys7z7j8j cord-267020-4mpc246u cord-266932-567lbktm cord-267124-8efdzlc0 cord-267287-qodj254z cord-266512-xh6zed03 cord-267621-oc8bw7ft cord-267525-tg4uwent cord-267357-7aap2cte cord-267041-i94lyfsh cord-268155-b8lqo52f cord-268049-7xqln70d cord-267300-zbipv9er cord-268168-yzvag38x cord-268140-s5lailkp cord-267132-nb0j6k3h cord-268347-xz6fptol cord-267788-ukz2wz4a cord-267947-dnv2xl0h cord-267402-kca05rvz cord-268254-1mg7a17c cord-268252-6g0vbd08 cord-268455-btuzihsy cord-268211-egy8rgtl cord-268632-p1rsz8fk cord-268324-86a0n0dc cord-268540-wrjzr3ws cord-268531-igjeai8c cord-268561-vq1uhj5i cord-268879-ajd7ofc8 cord-268886-mpceglk1 cord-268617-1t7yaoct cord-268952-3j43p9j3 cord-269051-nl0jfqxt cord-268843-zml9lbve cord-268939-ws74xprt cord-269087-f9hyntvf cord-269031-sz8ieltb cord-269280-1zbxjmxu cord-269099-q5nyzlhs cord-269009-0i2bvt77 cord-268326-sbz3uk5h cord-269564-r5mmsnbx cord-269289-6uog10j4 cord-269190-w74bjtq1 cord-269205-g6eyvnou cord-269275-b7xxk48t cord-269105-yuphgyrn cord-268974-7bqh1yas cord-270019-er70ehk4 cord-270079-vwnzp6zj cord-269345-5tlyy8jp cord-269425-e9iyso7n cord-269554-fzu6dy4e cord-269469-7pmnxi9a cord-269690-6r2bfydw cord-269503-ij4u980v cord-270294-g95skuik cord-270509-roc93m4f cord-270153-krhkqcev cord-269591-lu415jcp cord-266713-rghowch1 cord-270348-5804ffwx cord-269981-xm0by310 cord-270124-tqhkzd2w cord-270210-gfy2ytg5 cord-270327-v4td3zsa cord-270525-nmebqrb1 cord-270391-703js942 cord-270388-nozh463l cord-269835-mz7i66qp cord-269511-bfd1dmt3 cord-269776-hj1s3ipp cord-270665-z4l3lq39 cord-270712-v6nnnzhm cord-270776-oulnk1b3 cord-271603-zy4l9vtf cord-270245-zziwb2jy cord-270654-cz2y6ta9 cord-270763-idkylpb6 cord-270723-cjfglili cord-270876-kul6bs3w cord-270740-3su8pc3f cord-270933-ecmg8kti cord-271149-qnhlfozo cord-271180-cnrs0zpg cord-271358-5666nsb9 cord-271220-sntawlnf cord-270799-2pmpspuj cord-270628-jtj30v0r cord-271262-xglhx928 cord-271887-blwrpf38 cord-271212-y8denvju cord-271660-5sfkhg19 cord-271871-8grkln6o cord-271920-1dzkgt6w cord-271896-1ad18z11 cord-272427-jqs00ilp cord-271944-oxtus5vb cord-272553-bcmta2he cord-272143-6ej3eibd cord-272318-8yfg1j0o cord-272071-445ivhx0 cord-272727-a5ngjuyz cord-272585-346ef6qy cord-271483-33kuvpl7 cord-272419-y3ebt4jm cord-272154-nrm9ulj5 cord-272135-a09bf50o cord-272112-egsha2j7 cord-272655-qeojdpez cord-272630-2na1gndu cord-272975-gzsd4ybt cord-273090-fdzkfo1u cord-272677-6t9kl3hq cord-273045-ele1cz86 cord-272778-aixiioii cord-273426-55vu6b3u cord-272976-pb2bjpop cord-273641-8l57mnjt cord-273091-40gda9n9 cord-273602-cq276tj8 cord-273869-buavj9mm cord-273119-jfy0iviy cord-273283-gb0m6fue cord-273175-bao8xxe2 cord-273567-8fp3a9h8 cord-273875-vpp0l6ij cord-273929-kpcmy9x8 cord-273695-p5p7kvpp cord-273408-jtpaue0z cord-274199-3stjueja cord-273587-nja58vxw cord-273614-qmp2tqtb cord-274184-hm516x6p cord-273913-xem3alih cord-274250-95yzt1gj cord-273317-2e3vmdx4 cord-273758-hhd8xnve cord-274481-k1dp1ilv cord-274542-fpzk5k79 cord-274008-p3st70u3 cord-273945-b1lekw47 cord-274494-heu6rmbt cord-274666-0d8oz51l cord-274632-d9z0m2l8 cord-274557-2071770h cord-274331-0i2opmcn cord-274245-pgfqkwqg cord-273996-z5vlw6nm cord-274563-jimw6skv cord-274782-yymo9i6r cord-274556-531jlpwr cord-274282-hvx5m2bx cord-274779-0emfl1e5 cord-275041-fcdwitxy cord-274355-6hiutrct cord-274934-s8xppipe cord-274324-obhrbxu4 cord-275110-safr9z37 cord-274860-7ec2jcoq cord-274121-3w6kc0c9 cord-274802-7ioiwsd8 cord-275185-9br8lwma cord-275257-upj8mvzn cord-274871-jlquvz51 cord-275260-xuhxqkyj cord-275518-p03sl946 cord-275266-e6omvo5x cord-275004-qzg03dvg cord-275214-mqvw0219 cord-275477-blu6wjhu cord-276249-9opsg7p2 cord-275349-b35pt3mo cord-275154-vwnpred5 cord-275340-q8d7rvnj cord-276241-4g6pa7kz cord-276132-tv5y1eqc cord-275440-fl4dsu7d cord-276264-wgzh3f5m cord-276288-upv2o8f6 cord-276090-n8c2jpr6 cord-275272-qdg8sqpy cord-275979-cx2h5bsw cord-276267-77903fld cord-276359-syr9av09 cord-276234-2nkeq4ud cord-276524-th6eu11h cord-275506-3t5gf66c cord-275742-7jxt6diq cord-276405-yfvu83r9 cord-276303-lgywz9ea cord-276438-nynri6my cord-276343-sb3vd7fq cord-275913-85u6v3ib cord-276495-q22jnkn2 cord-276635-0ciy732e cord-276327-wyevh4xv cord-276676-lgt0rzob cord-276856-88d3vzbs cord-276621-9exp8e7h cord-276592-dsilwfl1 cord-276784-8lmg97zc cord-276782-3fpmatkb cord-276927-rxudwp2v cord-276834-20lcihf4 cord-277189-fe8ego7f cord-277096-zvb7n9wo cord-277148-xzpuc22p cord-277260-7se220oz cord-277328-9s8fwg1h cord-277014-iz8jo44e cord-277535-u283k70i cord-276641-40r4mitg cord-277539-xt2nt11e cord-277201-jzjxsetx cord-277146-4a4vz36h cord-277498-hdhq99k2 cord-277207-2my86ums cord-277576-3dvt6uj7 cord-277700-nxm1jr0x cord-275828-c6d6nk7x cord-277399-0w8is9xm cord-277430-x02u7oh0 cord-277178-nbotxv35 cord-277486-12uah5qi cord-277323-jqr2hkv2 cord-277210-xaj2623u cord-277818-8w15dz20 cord-277803-7p1qu2rf cord-277811-j58qvyum cord-278325-ykcd7d59 cord-276758-k2imddzr cord-278477-9a7gmzz3 cord-278300-6cr9h7no cord-277889-8u685f45 cord-278549-br9rr713 cord-278364-58d8kfdf cord-277739-eb4z3u66 cord-278547-y0hvq0qf cord-277992-49mantab cord-277643-xh8z9v0m cord-278937-lkuuftno cord-278332-fbksw3om cord-278943-f80ucqqp cord-278672-pxzsntfg cord-278106-ev1nx60h cord-278682-s4gfbsqy cord-278984-0zof6s4d cord-278319-44bvju3g cord-278993-w5aa0elj cord-278536-b4eyegx5 cord-278592-67y4f9av cord-279052-8hxdfdls cord-279134-s6c7m94h cord-279158-dsnniuo6 cord-279111-jaa45kyc cord-279435-ffgd2ets cord-278838-qraq5aho cord-278256-dmrtsxik cord-279299-5djtiomq cord-279456-oouylyx9 cord-279357-83hisxro cord-279056-mmcoqtb5 cord-279557-hk77e3pp cord-279480-nqp1pc9v cord-279238-d49jvws2 cord-279197-cesemos0 cord-279513-m4jdc8ua cord-279550-7u2hksxm cord-279667-ikfduu2k cord-279570-lgbqpfh5 cord-279396-qmixem8i cord-279732-cea0nt8z cord-279846-g0ro8pbb cord-279571-chiadufa cord-279483-gwikyux2 cord-279719-z0wuajpx cord-280070-c1bkhgaz cord-280129-a97rvtzl cord-280097-f7ky61ds cord-280278-gq1hnnwh cord-280005-i9fp5rys cord-279790-zzvetjrt cord-279736-udsbcqfs cord-280507-1nf2ycp3 cord-280628-ok62havd cord-280280-9jr7ekbu cord-280111-6hiuzkvz cord-280060-gzby85u9 cord-280360-rh37d5wc cord-280348-vrnxucye cord-280848-z0sbztkw cord-280030-neqycg6v cord-280233-avmisu31 cord-280984-2j8ckz14 cord-280821-kc0ut4oy cord-280241-h16s6wwm cord-280996-anq680a1 cord-280961-fka8c69p cord-280431-tuzdng4h cord-280944-uphs5gvl cord-281060-1ud5hzlh cord-281003-7pdhxdzc cord-281130-9tawihti cord-280551-9hoxy5ok cord-280794-k591vqji cord-280554-9jp85yzz cord-281039-a7q5nzwn cord-281276-rffp6qe2 cord-281064-b69p44uq cord-280358-ru2hv6pz cord-281283-h6yai7sx cord-281175-og3myz22 cord-281106-vzb5xzza cord-281332-5mddyv0n cord-281346-bjhdy8mg cord-281561-r10y2sgb cord-281391-0qkku2jd cord-281887-b511bjdy cord-281752-64mrflcr cord-281945-jvnjzjds cord-281344-iswbgqqe cord-282183-k0pn0ie2 cord-281566-6v5zfue6 cord-281298-qheq9lc8 cord-282483-0zsvhoog cord-282219-7kzbnymp cord-282097-a1pwq4fi cord-281729-z321pebe cord-282043-cs1oyohu cord-281733-bsq0ewac cord-282660-9x937eus cord-282361-gje78nb1 cord-282589-xof56j98 cord-281804-lhnw8jx5 cord-282430-u5ukqc5z cord-282535-gnuhjs32 cord-282021-m1lh7mzd cord-282151-mai4eggf cord-282724-zzkqb0u2 cord-282704-qg2o0ug4 cord-282474-74273qgk cord-282610-zim7nond cord-282730-pawasfh4 cord-282504-m3npy0om cord-283141-dh8j7lyl cord-282963-p04c5nn7 cord-282780-34j7gquo cord-282783-ps5jyjkl cord-282956-f7if9e5q cord-282867-kbyxdegu cord-283165-mdkr9qo0 cord-282912-jegpgqqi cord-283738-v3h7p297 cord-283513-3f4rsgzm cord-283215-dgysimh5 cord-283517-7gd0f06m cord-284163-3jmqzemf cord-283583-pwlbrxn3 cord-283267-72wrzw09 cord-284038-93s3ffoy cord-283826-lgyc3sro cord-284188-ujdla954 cord-283719-zmizyx7e cord-283806-a6exd6dn cord-284042-awl5bb0j cord-283779-mudwcypl cord-283231-ju71zm7w cord-283682-4fcyoyea cord-284387-cjziykrz cord-284298-tcied4l5 cord-283969-wqrzaxsu cord-284365-g46myqe7 cord-284454-malfatni cord-284545-vn60yd46 cord-284175-5rre1kbn cord-284332-p4c1fneh cord-284983-xvtkso79 cord-284526-a5kgo4ct cord-285472-cj5r3xt1 cord-285354-bp2dozzg cord-285469-b61y9ezi cord-284979-lyt98od1 cord-285360-svczr721 cord-284995-8lyr3gs4 cord-284576-nemh4wdo cord-285897-ahysay2l cord-284804-6i5zbmm1 cord-284251-brn5izwo cord-285291-pep4opiq cord-284944-hcgfe9wv cord-285818-eh12luma cord-285467-uxfk6k3c cord-285414-vd2d7db2 cord-285755-zblitbo0 cord-284910-vjcrhwqz cord-285226-4ydvjmr3 cord-285757-fiqx4tll cord-285867-61y4aamj cord-285907-xoiju5ub cord-285588-ug7upa3r cord-286227-foeb0g7u cord-286418-9ho5fg3h cord-286403-gdkwabcj cord-285298-r7p44wpe cord-285732-xew5ar1e cord-286096-h275nner cord-286638-bqxyb61p cord-286525-0354438s cord-286477-0euaaspo cord-286237-x6dr6rsh cord-286574-t9z2ynt5 cord-286683-mettlmhz cord-287048-5od0ssyk cord-286743-z0e5arlm cord-287102-o19uwryp cord-285772-4xt4anq5 cord-287117-3v9nyagt cord-286293-f5qg7vcz cord-286611-e1i1wemo cord-286853-9gbel3pq cord-286843-8qh1pblc cord-287515-oe7adj91 cord-287468-e5h4tmy6 cord-287373-7xjn05k8 cord-287222-wojyisu0 cord-287210-sars5dmi cord-287508-133inel2 cord-287367-1sdt9zz8 cord-287161-hqrql1lh cord-286607-5i406twr cord-287520-51kmd2ds cord-287558-yc8aw2pg cord-287544-n32iscmr cord-287648-nhsn4cru cord-287376-wxldnlih cord-287786-zfe0el8i cord-286334-d9v5xtx7 cord-287538-qbf5lv7d cord-287505-ihqzpdar cord-287742-y1j9x5ne cord-287497-93oiiqqi cord-287765-nsdequl9 cord-287901-56goaqir cord-287957-diyz54qy cord-287874-wl0wlxh6 cord-288033-9xu1ujcq cord-287732-abzpfdcu cord-287895-63wy5ztb cord-288040-uuqfvvmk cord-287953-prn8cnvo cord-288102-iom6lu7o cord-288067-36amafub cord-288222-8fqfbys2 cord-287758-da11ypiy cord-288158-6gicgsj8 cord-288271-p074ffpt cord-288009-8i3gsq9p cord-287991-10jz1dz2 cord-288197-drto66xt cord-288580-onzzpkye cord-288558-rthnj6wd cord-288371-uyj4iske cord-288181-9thl46oe cord-288255-p8uzrsbd cord-289006-7dv1zsp9 cord-288051-wp8v2mc5 cord-288697-9dywuhkc cord-288509-l6yn2er7 cord-288790-5uzgenty cord-289064-435bp4rt cord-289179-3zfur0zh cord-288575-srpc68t8 cord-288606-h8pmqwmk cord-288810-ab7k70c4 cord-289046-frhpt8n9 cord-289311-0wgafqdz cord-288552-7lp07v5i cord-289054-fh95b5n4 cord-289457-06gwrpu0 cord-289542-u86ujtur cord-289115-bntcn0m6 cord-289719-64ugdvfe cord-289219-qjxdggz3 cord-289690-af6lsj1g cord-289088-7uoia564 cord-289322-5ciaonf0 cord-289008-c4cu3vrp cord-290006-63sa00ju cord-289574-engwi8h3 cord-289581-aozg3o9o cord-289169-3u7qgxud cord-289816-rlwoy8ms cord-289859-b1k9uyp6 cord-289553-gygvhzcc cord-289930-7xm6q68s cord-289114-ifnk41oq cord-289533-hip9qtu5 cord-289854-p8okfa4b cord-289806-6ihptx6n cord-289775-40bi87iz cord-290041-zxlq63n5 cord-289828-3k088z9n cord-290028-oyd7vzj6 cord-289612-4x5t4c5u cord-290081-pjg00t7g cord-289973-1mczuxsy cord-290200-csmisulw cord-290551-a02tueuu cord-290065-ouua7wnq cord-290401-t87i3exo cord-290267-ke696q8j cord-290295-gl144dh9 cord-290341-ei768v4s cord-290658-r2bqqovo cord-290051-22gwwrpw cord-290712-flj352ql cord-289852-4uxb70rh cord-290195-8uaai9nv cord-290975-2kmvyovm cord-290750-85731og8 cord-291016-c83fs5ih cord-290326-umv0q4d7 cord-290611-fhaguv3f cord-291265-qmylxndp cord-291052-nstfe15a cord-290832-zmj59rc3 cord-290856-6de0mwg0 cord-290947-5ewpvo4j cord-291024-9g4om4sf cord-291340-8gj0ofmp cord-290771-18dj37dj cord-290836-jldfrec9 cord-291168-4u4cssky cord-291397-look6ddt cord-291176-evb6yt0r cord-291025-u5z8zji3 cord-291388-tt9eq7e0 cord-291244-o4isx15k cord-291469-cohrewj5 cord-291413-cgec7150 cord-291624-fod0eyuj cord-291686-kgewmqg5 cord-291588-tp89j1kk cord-291417-p49ukyhx cord-291430-rsu6xviv cord-292056-dtdyxhq4 cord-291670-mqj071gp cord-292345-zc209dfx cord-291566-jwlvustd cord-292315-7vwybku8 cord-291697-wpnq9wc0 cord-292474-dmgd99d6 cord-292054-x0saq938 cord-291687-kwu0otpi cord-291855-wtwz94sy cord-292561-iy06b9h9 cord-291873-inzzywps cord-292620-t8ocqm6g cord-292394-91b3mm6c cord-292493-lx7zfgoi cord-292335-al6v3b9x cord-292485-vk5xy3zn cord-292350-cmrtg91a cord-292387-2xv3wgaq cord-292826-lus0tqmi cord-292094-vmsdhccp cord-293167-3bd3adip cord-293285-w8c3ma8l cord-293143-1k170shh cord-293333-mqoml9o5 cord-293575-h3wc7j4v cord-293180-f1ulk9ce cord-292952-z7ajsf2r cord-293570-gh6ykmea cord-293522-gg706q8s cord-293730-dlqo6fep cord-293086-6282sb6b cord-294057-fbox3a5q cord-293964-hz5uow2b cord-294487-hcuzxhb3 cord-294073-65h2mkdy cord-292856-7hjzzxtm cord-293547-29i3u83s cord-294108-uvnh0s9r cord-294336-fqobpo47 cord-293852-r72c6584 cord-293472-d3iwlpsr cord-294270-do6i6ymq cord-294184-jte9xx5e cord-293634-4rryqbnu cord-294349-ps3qlho2 cord-294443-w6p3f5qc cord-294617-i8j36bol cord-293922-knzv4jvj cord-294139-78c5h7la cord-295123-x2gxgave cord-293704-tnik6sd3 cord-294636-xes8g0x4 cord-294294-66udu5y4 cord-294527-fct2y5vn cord-294079-px9c20il cord-293740-4c3yemi3 cord-294628-ecg13s7a cord-294371-xot2oj2t cord-294907-i836d6im cord-294933-oc2glu4a cord-294064-vdpak3fm cord-294969-57xgqf2g cord-294959-xy8976jz cord-295514-vhymj0rw cord-295216-eff02z0i cord-294768-bs6thjw2 cord-294557-4h0sybiy cord-295086-tc3re52f cord-295332-wlnss6bg cord-294700-pb5k21da cord-295323-snrt9odv cord-294593-mh1uh1b3 cord-294810-mq9vjnro cord-295414-v10454ns cord-295371-ccqne6nu cord-295700-lzaxzuwe cord-295144-tyyc81uc cord-296018-lgx5k2kp cord-295800-w0dup04b cord-294788-9usyb1nn cord-295971-jtv1jj2z cord-296113-syi2fwuo cord-296182-hhswage4 cord-295798-x7or932x cord-295523-5pv7kw6i cord-295794-glcg36si cord-296588-q2716lda cord-296494-6kn4mr04 cord-296562-3h2oqb9k cord-296013-6ej3pd0u cord-296605-p67twx7a cord-296219-zzg9hds0 cord-295703-no45mgyd cord-296676-2anl2agl cord-296331-i4hyzqcv cord-296440-18vpg419 cord-296694-2js639bk cord-296607-h2zwlyz7 cord-297127-nhgm09db cord-296881-2g81sjnl cord-297208-f4ob3ox6 cord-297132-lhfa9fl5 cord-297138-t8b3914h cord-297093-ld89vmct cord-297327-19dfgfz6 cord-297532-ktiwfcop cord-297638-ab70s980 cord-297832-picpuzvo cord-296773-5o4hr6ir cord-297759-arg71du6 cord-296936-5gkx4jxa cord-297414-zq16s9ud cord-297836-y9vt6wvu cord-298067-awo3smgp cord-297494-6yxmaihl cord-297001-4g3wb8qi cord-298034-0ntxm28a cord-298325-2gm4fnqi cord-298516-0eda4mzs cord-297518-6y2uzcde cord-297506-1xjgsz4y cord-298679-w0yp4u19 cord-297840-z5l6vdsr cord-297425-vcqqssm8 cord-298094-ctikhqvr cord-298403-ilpzj2sv cord-298056-svwtfshi cord-298787-4vo9gpiu cord-299024-jkqdzt87 cord-298894-t5hyfum3 cord-298967-vjyh1xvh cord-298974-69xjc5yq cord-297870-m7n43k4p cord-299082-s8bm40vy cord-299681-smhto9em cord-299489-6v225vte cord-299222-vmofcrim cord-299570-1xz5r95f cord-299333-qu0bmov5 cord-299124-g70v4crs cord-299156-1dwsm3ie cord-299449-226dd23u cord-300038-1fjb6b8e cord-299881-weptfpa2 cord-300356-oorac5he cord-299835-92karhpl cord-299750-zkrlm3ds cord-300044-vn4c6wh7 cord-299621-m4kdkmey cord-299254-kqpnwkg5 cord-300344-57vxlctl cord-299679-6z9e5gi6 cord-300995-tqz2bkdo cord-299784-xxxdjfbc cord-300608-eju7wnb9 cord-300774-5mrkmctl cord-300559-vuuxthx2 cord-301011-xbuqd0j5 cord-299346-f13xly6q cord-300183-z3fwtwqb cord-300510-fhpkdqr0 cord-300697-p96i25uc cord-300458-jeuwaj50 cord-300445-qzu4gz2d cord-300866-cso6l6ze cord-300303-d4qmtysd cord-301079-n1nytr6k cord-301281-yur5hs2h cord-301391-5dvf1mi0 cord-301342-ikvpkhfp cord-301146-no9pw4gn cord-300811-l4y7df2f cord-301592-n5ns3m34 cord-301087-9vl5pqi7 cord-300963-1n1f8mf2 cord-301811-ykpiorgo cord-300080-l0fyxtva cord-301805-sb0ij8k7 cord-301832-6czrdmzb cord-301340-lhh04pum cord-301579-q23nhmgs cord-301590-70qmpccs cord-301521-mpm43aga cord-301148-duttw9xn cord-301402-andxwyi3 cord-301947-b6nwaost cord-302062-wqmynngg cord-302115-r39ser2c cord-301992-oin1m0uq cord-301779-y07xjnpe cord-301800-ssdzd43t cord-302244-uwicyuhk cord-302389-h7jm1etb cord-302316-raf5rlkq cord-302215-sqrbj5r4 cord-302459-grs2x26l cord-302448-2r4rtixg cord-302667-ei151qpd cord-302684-r4ger87o cord-302177-8w3ojgd4 cord-302413-7a80jff2 cord-302788-kg8zwysg cord-302226-0rhgmtbo cord-302695-vyo3w2a4 cord-302862-znnlyz3y cord-302382-eifh95zm cord-302806-1e99cygs cord-302864-2xnq1oq7 cord-302403-kahi8cbc cord-302576-fv2ib5vc cord-302756-343y63e5 cord-303145-rc5luali cord-303600-96vtj89w cord-302997-39o08tt1 cord-302821-b9ikg0xy cord-303192-il3s8lgp cord-303244-5tfrmsm7 cord-303065-dyg2baog cord-303017-4zx94rm6 cord-303054-s1clwunc cord-303460-abutfxtf cord-303661-etb19d6y cord-302800-852w35od cord-303483-wendrxee cord-303349-0kn7apl3 cord-303363-uu9hb1c9 cord-303880-zv4nbz9p cord-304010-n4gxxl5i cord-303718-7bpap31f cord-304090-l5rocsk5 cord-303816-c4z9ys3q cord-303517-8971aq02 cord-303787-dx1n8jap cord-304271-vyayyk50 cord-303819-w1785lap cord-304573-3nhglbw4 cord-304602-jpxjiaru cord-303703-ekhwb5xb cord-303860-jpy373ph cord-304280-2a84u4tm cord-304601-e6qlx1r6 cord-303791-yw80ndg6 cord-304949-mf3utolt cord-304248-sxbyxnxn cord-304593-cugypxp0 cord-304474-hfv43e9m cord-304457-8g36h1bz cord-304418-k9owyolj cord-304255-7xs9cit7 cord-305134-s7h6bpof cord-305139-851v2qr3 cord-304798-j2tyjo1j cord-304321-y177sqee cord-305520-7gxmdo56 cord-305076-v56y5nyt cord-305397-4dx3q6o6 cord-304399-7t2mu13s cord-304791-wv4qu9xm cord-305283-1bg1ykui cord-305205-ilxxkm0f cord-305498-8tmtvw1r cord-306092-5bi2q3jj cord-305838-i0ck2oo0 cord-304972-aktfbriw cord-306062-g9hk1iq5 cord-305650-su6furzi cord-306149-sd0s0jup cord-305304-d3x734nu cord-306090-i8sriw08 cord-305422-t8azymo7 cord-305479-o47mv4uw cord-304479-uxp1kg86 cord-305405-me4gebvm cord-306266-8qdrshz3 cord-305959-x061q8t7 cord-306108-ja0wyr5w cord-306595-ru725fbr cord-305534-936peb1n cord-305582-3hmsknon cord-306790-82nltfk3 cord-306670-c2jm0g88 cord-306016-2gudro8v cord-305786-06dpjik8 cord-306351-ka6asw3m cord-306154-nm0g79ih cord-307100-w33e2078 cord-306997-84pjfawk cord-306377-s9j21zsy cord-306646-6c7n0xir cord-307160-1vz0gw1w cord-307258-66lwpblq cord-306896-khn8epxd cord-307660-onz6vfre cord-307217-0agij3z3 cord-307653-nyr6mtj1 cord-307285-bxy0zsc7 cord-307758-a4sgt66g cord-307690-1qqyixun cord-308071-1bk3xuwf cord-308010-ix0xi5jb cord-308390-ei96iuw3 cord-308184-w8ewm8ve cord-308075-1ftswsm8 cord-307309-s0t4kp2x cord-307862-a082sghm cord-308169-a0ft6wdy cord-308252-qwoo7b1l cord-307710-dlpfbnb1 cord-308112-w96ncfla cord-307287-zpq6byml cord-308195-nlibv0u4 cord-308002-abgv87e4 cord-308907-elz62jlg cord-308466-f0iu6sje cord-308313-3speddao cord-307808-0t6sw0zp cord-308212-l8flyso7 cord-308491-fc46k594 cord-308445-3j2q83ll cord-308906-et7duogt cord-309214-v2iqgjc4 cord-309207-n8u8ddv7 cord-308979-qhlvd2mt cord-309024-pu830bn9 cord-309236-p4c2d5y3 cord-309001-erm705tg cord-309194-jtouafgd cord-308803-i934doud cord-309370-g8d3w7it cord-309421-725u6dau cord-308968-m4pzsfkd cord-309395-5yan9fcn cord-309441-obojsf04 cord-309302-n6cd2fc3 cord-309026-l2rh9bie cord-309323-yflng8m3 cord-309561-m43v332d cord-309507-oe4i6v5x cord-309482-frawgvk7 cord-309751-7elnvjk3 cord-309238-7lbt0f03 cord-309360-cpis1l4u cord-309728-7vfotgrr cord-309706-kikx05dj cord-310010-oxgb6xnv cord-309829-3dlfcy31 cord-309735-bwa1zo07 cord-309962-phwq8rsf cord-310069-ay4af6xr cord-310117-19qsszns cord-309517-yh4d414y cord-310166-gt6icwul cord-310240-otf9ruvj cord-310891-yfouizjb cord-310001-qng7h5cj cord-310661-hrvuhkq9 cord-310597-zy6ckr53 cord-310405-7fah22nu cord-310084-taaz6mhs cord-310690-50z2kdaj cord-310823-xksu8fn1 cord-310974-hz37yf39 cord-310663-504p29hv cord-310539-8zk3hkgj cord-310901-oooat8xj cord-310205-j57x9ke6 cord-310177-4jw1lkli cord-311341-7ox30d2u cord-311043-nidu7om2 cord-311275-ysr9nqun cord-310902-cfci8lef cord-310976-24b3c3a4 cord-311074-j3fw4dfc cord-310676-125o0o7x cord-311373-ngs7baoc cord-310685-gi2ycrfk cord-311044-kjx0z1hc cord-311730-189vax2m cord-310779-4puiao40 cord-311176-dlwph5za cord-311579-4jhoatkw cord-311673-z4hkw17g cord-311682-npi03i7q cord-311752-stqrf50k cord-311970-o9xao5rl cord-310917-9sk8gdh8 cord-311215-x3b7ewo2 cord-311848-8n9ee57a cord-311000-abntwzuy cord-311847-2czqs84q cord-311418-7core0y3 cord-311942-oju4gosw cord-311816-j8c2lk7y cord-312065-nqy7m38f cord-312199-jy3izkou cord-312249-k7dp776s cord-312063-5c2w2ct1 cord-311838-ymn96yj4 cord-311957-3rmm1hfb cord-312012-6a7i72bk cord-312313-guphuppy cord-312192-hxhohtmj cord-312388-pc89ybxw cord-312609-gv1khfmo cord-312212-h5j4f0xq cord-312486-rumqopg0 cord-312033-iarl77n0 cord-313028-0nhgxoim cord-312467-kbhljong cord-312677-rwznqiib cord-312572-i7r28wdc cord-312209-3yi1w44v cord-312057-4zfaqkxm cord-312748-9v2bmbod cord-312614-63qzissw cord-312798-2cbgnv1h cord-312795-0e4esl2o cord-312846-ef7m4875 cord-312918-iof45k1r cord-312754-3yhxcfr2 cord-313136-ab56mg6j cord-313082-n3bo9jw1 cord-312847-2cg3ylfl cord-312632-g4250q6l cord-313294-ffgo56gl cord-312684-3i2r2ahr cord-313349-ikjivfce cord-313353-uwwih8v3 cord-313118-dv5xq2k4 cord-313728-08kwkbmd cord-313494-a4pms2ub cord-313227-6zwkfzab cord-313468-lloh1b0y cord-313239-0gl43af5 cord-313529-xm76ae08 cord-313628-6610z7xk cord-313693-qmkrn7pr cord-313684-61hkogdh cord-313785-8tipkksu cord-313976-q5j5kr1v cord-313528-rp15vi1o cord-313894-stgx36h5 cord-313836-mcm0xmzw cord-314088-ktj17dvq cord-314218-6znw9zcz cord-313860-mzs3ya0s cord-314070-8qz23nn4 cord-313989-bc7q8swu cord-314171-431buxxr cord-314152-wd153s1g cord-314378-cs9ggqwk cord-314280-kf2bo06e cord-314649-1y3ocvz1 cord-315056-ohyb6oa0 cord-315311-azamwuzl cord-314537-8a1vqale cord-313474-1gux1gsi cord-314694-g0pes5o3 cord-315116-u7btx7nt cord-315249-yclnl87n cord-315297-o8mwmjql cord-314826-usfvulc2 cord-314349-rhm1ii3d cord-315188-a9pvugjt cord-315397-cm3mc7we cord-315195-m2xqlct8 cord-315181-emf4i6ir cord-315486-pjb5v1tc cord-315569-e56c5g8h cord-315574-jq1p5t8w cord-314106-r3axl3w1 cord-315970-m5o962yw cord-314449-ukqux772 cord-315149-71bmj5il cord-315696-43wmazxa cord-315834-ashjw2xs cord-315424-i3nnennw cord-315490-xs5v3uc3 cord-315871-anguylf1 cord-316067-mlcczr8c cord-315157-2p45frlk cord-316003-xt59voyt cord-316170-ihh0pxov cord-316135-kevyw19w cord-315730-fzgxuak7 cord-316083-f1h2j6jx cord-316137-6zdxfv8v cord-316306-vfez5k02 cord-316029-z708c3ex cord-316432-xemz7zn9 cord-316728-vyfkmniu cord-316095-jzyb4jn5 cord-316666-qif1k62t cord-316370-t802kjpk cord-316118-ph582weg cord-316376-76beuk0c cord-316673-ffkh13xm cord-316117-o29773cz cord-316845-k9zvsfvj cord-316572-7ei96rrn cord-316647-jj8anf5g cord-316835-qf0c91vr cord-316987-3nhqx2qn cord-316522-fbw9x3ik cord-316873-2gwl9m94 cord-317075-zegearxa cord-316938-64jxtg9y cord-316616-j82q99in cord-316743-q6gbxghx cord-316764-ps89rxuy cord-317028-f3bpwm5j cord-317265-n6x0r58i cord-317242-e7000i2u cord-317151-cxx5pcln cord-317085-qc8bfb9g cord-317535-zep5axfo cord-317344-wznzmssz cord-317468-pnxni1x5 cord-317604-j8b64a1a cord-317811-mxsujb5u cord-315598-qwh72inx cord-317566-6ch6na31 cord-317689-gp4x54pe cord-317918-pl625ela cord-317809-umb8j63t cord-318282-ocgfgx9r cord-317932-5sqj2klm cord-318063-bainw3d6 cord-318167-b25g6zkp cord-317952-4oa9hfb4 cord-318021-4qrf5m8s cord-318094-losjbgn6 cord-317575-srg9cyqp cord-318311-aakpbbvl cord-317966-ut6tzc8s cord-318229-29cgwivt cord-318262-w8oixzdg cord-318333-rzhrgp5q cord-318355-38x3f3ee cord-318954-pj5lsvsa cord-318909-h5b7mncf cord-318326-q9fnbg8n cord-318803-xpa49sxt cord-318873-zwot69s3 cord-318830-a3n4c5d1 cord-318944-13zk6cco cord-319333-jwbgytwd cord-318369-y3wtfqrn cord-319037-77l9wdyb cord-318312-v1c3qm7h cord-319400-lghjiw5p cord-318520-hgjv7ot9 cord-319742-ypkt01rn cord-319849-3shr5grg cord-319930-ymqnb54a cord-319218-mejvlkfg cord-319615-p2labgd8 cord-318808-1cfwj5uq cord-320445-pdvkyzci cord-319567-4t5t8bcx cord-320572-94fvtj4a cord-318694-370ccaoc cord-319013-oytqcifa cord-320612-vam0bli3 cord-320349-6hbuq0k7 cord-320599-hxn4bgec cord-320184-wacoz5t9 cord-320149-3q4q98a6 cord-320811-9sm7iz5x cord-320788-ln8ddyuj cord-320634-x7a3k5xu cord-319823-sp5wibeh cord-321346-epsp3bbm cord-320877-1i0hzfjk cord-321064-pe8466n1 cord-320632-369kax2m cord-320663-xypg6evo cord-320892-dcfi5u04 cord-319706-2e9jrv0s cord-321543-qdmvn44h cord-320864-k9zksbyt cord-321149-hffj7s4o cord-320695-gq7k331z cord-320831-owfnttqr cord-321030-isc3p46t cord-321748-9a54ekac cord-321768-oevswvvd cord-319805-b6ypt5d0 cord-321311-v2i1caug cord-320267-n21jryi2 cord-321461-1s3y9kc5 cord-321594-x5wv9p7n cord-321651-7e8dwcur cord-321237-ynhdii60 cord-321983-566pbuic cord-321788-z2y1ywdq cord-320477-zbp8a8dr cord-321552-lsz1onrj cord-320930-9yiu0080 cord-322009-0cwljo0c cord-322063-96suqyfg cord-322054-whjisspt cord-322066-m8dphaml cord-321472-n4nnmlv1 cord-321837-0r86qxz1 cord-321801-w66v5kzh cord-322052-zsbisk3b cord-322394-b18fv3r3 cord-322322-woz6lwdu cord-321784-nubu5fuz cord-322439-86dojc70 cord-322102-4fi0y96f cord-322259-khknne8s cord-322534-eikz07zz cord-321697-yua3apfi cord-322497-hdy3va8e cord-322746-28igib4l cord-322552-95bj65qf cord-322867-1yxxe5d3 cord-322590-twnlaq24 cord-322868-o3r0y6bz cord-322448-s04e6po9 cord-322957-clf8f90t cord-322663-a58e6pp8 cord-322799-opf1qwgl cord-322990-q07yy5k8 cord-323133-gdg50omp cord-322893-av8hj005 cord-323024-blc3mnbj cord-323225-ou7pppum cord-323255-elwfiima cord-322104-f1dukpso cord-323180-3ih0i81s cord-323092-j2u0ny2u cord-323446-w2ci1bfr cord-322861-q7uk6rdp cord-323314-y3k9dntf cord-323293-4gmnkg09 cord-323470-lpeeugdf cord-323463-osf6t7cw cord-323538-9dlr6kqh cord-323647-q67fa0m3 cord-323809-bocidwg4 cord-323713-bc00vths cord-323273-q53wf6au cord-323582-7y8pt72r cord-323489-ro7kbnu3 cord-323831-1qadv7r1 cord-323910-lms3xw4k cord-323965-6mzzibj8 cord-323705-n2rec4i8 cord-323906-ro078y52 cord-323980-rcyjthze cord-323787-9lq8rkih cord-323816-3m1iu9j2 cord-323761-9m177ozm cord-323913-v32c2vda cord-324175-5c4ijkpm cord-324041-lqokztor cord-324007-hapzf0fl cord-324159-jv3lknl8 cord-324669-qca0uwxo cord-324232-nupi7f72 cord-324666-fvk72o0p cord-324245-cfiekxr4 cord-324060-vvexfg1c cord-324601-s3rgxtg6 cord-324125-wau2xq0x cord-324314-os1btxx1 cord-324148-bllyruh8 cord-323940-ubazgvov cord-324880-s1oqkqef cord-324859-0yuhb5dl cord-324843-r43u7sld cord-325201-yoy7kdli cord-324529-xbrdtxnz cord-324635-27q3nxte cord-324809-16zvqizl cord-324619-y7gilopu cord-325628-pa3dkz2f cord-325619-qmszgw66 cord-324944-ixh3ykrc cord-324810-92fosk3c cord-325511-ot66dj3i cord-325234-skshcrh1 cord-324918-36om8n2d cord-324679-rds8o5z4 cord-325655-1fktmpbj cord-325307-agaau27o cord-324798-qh0cxp10 cord-325316-uffxyas1 cord-325793-5vrr7msw cord-325421-1ysn0kyr cord-325766-hbppklm5 cord-325869-3mvjc805 cord-325649-zzhsrytw cord-325783-pqonn0as cord-325970-ivtunxrd cord-325863-3t73v4ng cord-325631-c7jwizpj cord-326185-gjte739i cord-325700-f102uk2m cord-326023-vwukiwe4 cord-325933-1qvpofvp cord-326703-akn92p1r cord-326272-ya3r0h1t cord-325971-volbaipv cord-326747-zwp13awk cord-325963-d0hvukbu cord-326643-obfvi3ms cord-326017-qw4qynqv cord-326468-xcy7v1tf cord-326752-45ckkv01 cord-326851-0jxdnm1l cord-326354-fhafg41x cord-326984-o27rp468 cord-326751-fn43p19j cord-326807-dii4u9gj cord-327017-b2refzfw cord-326834-eeldyj2u cord-326883-j7pbe50g cord-327165-vlyfbiem cord-327148-dzozl70h cord-326991-m0lfk0a9 cord-326785-le2t1l8g cord-327370-zo0n8wf6 cord-327349-rxb6zfoc cord-327432-ogw27tob cord-327125-86ocr70d cord-327413-zdbnoy1q cord-327214-kcbxyhhh cord-327397-8rxjju0t cord-327545-y3vejwtr cord-326994-y8p724s4 cord-327442-e02y93f6 cord-327611-g2ssh0fk cord-327577-c0d09cyk cord-327415-nu1msnui cord-327632-2hz94uuw cord-327764-4nlg26p5 cord-327481-m9r0p84v cord-327989-6p39cx2e cord-327820-4bm7b934 cord-327720-m6cofbj6 cord-327818-1abweqko cord-327622-ezgufe24 cord-328068-qoz85x3r cord-327961-ysatxwph cord-327597-fgnrujsf cord-328040-5qd05e4r cord-327609-no58ucyq cord-328214-2azb8789 cord-327690-di7hfghi cord-327836-6o66a4i5 cord-328484-4iptwc3n cord-327827-oliw4ee5 cord-328384-jzfr2t3p cord-328438-irjo0l4s cord-328289-3h3kmjlz cord-328829-yywxmioq cord-328786-gkd9xcxa cord-328147-61gtx2h2 cord-329351-g9qlo3xh cord-328607-lzai90zq cord-328895-p75b7jii cord-328039-xt17gvcp cord-328525-80xk3gln cord-328113-eczjjc2v cord-329152-1ixylnny cord-328640-4g7revha cord-328220-toeq4xq0 cord-328814-s3963anw cord-329564-tmi1u224 cord-329215-awxfetdj cord-329582-y4gyw8vz cord-329741-604gtqx9 cord-328513-81yvcgul cord-327641-hqnem2zs cord-329863-r2vqsg5r cord-329453-ry1diso2 cord-330431-9txstz4n cord-328569-1lx3fkv3 cord-329344-06uk5sjp cord-330050-05nnihst cord-328294-gii1b7s7 cord-329727-h47q76y8 cord-329877-vish6v8e cord-330061-q4xi260z cord-328487-glwslgjy cord-328307-378cfb23 cord-330368-rk31cwl4 cord-330676-urr9oqfc cord-330655-crfj5adf cord-329444-t8ixrdpq cord-329766-9bwdb6o2 cord-330666-puhijixa cord-330831-3b7vfv9b cord-330359-c0l5xq5m cord-330136-o8df8szx cord-329985-5rji08p7 cord-330701-k68b0wqe cord-330869-k5ro0edf cord-330856-j1wqrc8v cord-329856-0m5mc320 cord-330369-75cotmn2 cord-329989-176cvimy cord-331109-a8e7r80d cord-330573-rr2r8245 cord-331273-1fixwxuo cord-331604-jf6ybip5 cord-331317-q01uos7a cord-331434-2x9m37cw cord-331114-lumfg138 cord-331268-kzy33hdb cord-330492-kbob8z48 cord-330870-l0ryikhv cord-331449-0sow1im8 cord-330597-nftwj0d5 cord-330918-hsy8h1vb cord-330877-nsx4b4rm cord-331270-12zx0o2p cord-331481-zeaqi1uc cord-331487-jh34klbg cord-331452-y5lhawqo cord-331165-2yn1n3eq cord-331519-ye4dtna5 cord-330963-w24q8sn7 cord-331533-0toegbv8 cord-331547-uqmjhhna cord-331500-l3hkn2li cord-331762-b0yufidn cord-332036-op6s8tr4 cord-331827-amg309uz cord-331915-7idktu7c cord-332013-bl5d4xkc cord-332145-rw16o02g cord-332153-fczf3lzc cord-332233-01rdlf8l cord-332709-0plblo4k cord-332087-xwturwju cord-333340-ekok0mp5 cord-333588-3krh1xzx cord-333470-0a0i6vjn cord-332150-j76726no cord-332278-2p64ab2z cord-332861-7b5pzmk6 cord-333451-p2plpeew cord-334524-8uqnlpvc cord-333113-0k6xlmem cord-334367-w96iqo6q cord-333453-v3gap8kj cord-333816-cznwzcn9 cord-332055-lrpfzsog cord-334324-remrcm2q cord-332180-dw4h69tp cord-332788-8lq9qygn cord-334715-902pfxyz cord-333183-xyuj1j57 cord-332774-t5untewz cord-334790-lav794w0 cord-333429-bq7kfpby cord-333696-3ci9re9a cord-333024-1yrmun3z cord-332778-rf47ptj6 cord-332480-3uodkrkp cord-333375-d7cgvjsm cord-334408-w0yxz7zb cord-334092-50r3h7jv cord-333688-bykbyojs cord-332992-8rmqg4rf cord-334075-ruqd2c1j cord-333684-j1sg46w9 cord-333175-klnxnxwm cord-335168-3ofarutr cord-333698-e73d9lbu cord-335078-z7k59k8o cord-333808-deifddar cord-335597-anrzcsrt cord-333142-ek7hct52 cord-334212-3gqzeakb cord-334881-x9nxxled cord-333528-9mczqtje cord-334235-ymsiihwd cord-334495-7y1la856 cord-335312-yp73z008 cord-332650-05oz5zwz cord-333654-8rg99di5 cord-335351-8hdok02n cord-335033-cwhm7v0s cord-333876-fhxkpbq7 cord-335759-io18c6z0 cord-334188-bggt1i2e cord-334002-irbpehts cord-335576-b34nc3ay cord-335198-qp964238 cord-335140-njg0ln33 cord-335593-cjb0daps cord-336053-cjq7szcn cord-336194-5v395xae cord-335338-wzxjn5ip cord-335916-fh28qrt7 cord-335465-sckfkciz cord-333749-45v6b4tc cord-335680-wsczl68g cord-335095-epsi5qq7 cord-334773-yw2qgv13 cord-336306-hvy9ukhh cord-336252-e92omqyr cord-336258-dxps48bo cord-334835-j6u8t8j2 cord-335719-tnimrff9 cord-335540-lahu5dno cord-335265-kuc3v5m9 cord-335382-fk4um9nw cord-335795-hdko0zdw cord-335141-ag3j8obh cord-336268-azgswke8 cord-335892-hwahcec5 cord-335918-uc225mhn cord-336368-sudi4mdx cord-336336-f01khqqr cord-335744-haj5a7tf cord-336201-fl606l3b cord-336314-xf6zvvl8 cord-336000-v88bq4bx cord-336390-ptnpgh3j cord-336395-v157jzvv cord-335975-m6lkrehi cord-335977-f00758o2 cord-336423-rs4bma9b cord-336438-mlgxiyur cord-336790-29im4gxw cord-337088-xxyhmn1t cord-336450-2ndan331 cord-336554-n8n5ii5k cord-336462-7dltsav4 cord-337094-aa3ourc6 cord-336621-0w3rroir cord-337115-vtjsigod cord-336614-u6alc6rs cord-337487-1lbopaso cord-337297-fkw8780t cord-337120-irpm5g7g cord-337010-dgy7qbl5 cord-337262-88qpfu6b cord-337338-7uj2r0gy cord-336782-0zkb39v1 cord-337896-mct29erg cord-337898-ncrbd8rp cord-336882-x9e6r0h0 cord-337302-fpz2jfuj cord-336563-hwemigk7 cord-336488-opjjowcq cord-337906-qis8h3r3 cord-337520-qp0ga6q8 cord-337995-z4rcczki cord-337644-aobdzwpx cord-337665-roelk7i5 cord-336810-77wq9laa cord-336784-24qizp9k cord-338146-am5gg1qd cord-338968-b1gg2ha7 cord-336543-ydrmlujj cord-338192-2v9dbc9h cord-337622-rc9pejmo cord-338517-1mxcssjj cord-339015-qn8wbnlw cord-339021-mhdaov1f cord-338666-gg9qcpmz cord-337994-pkklt77i cord-337926-6ddvqowr cord-338135-zwo7e7gy cord-338362-6zwvkqag cord-337431-3rrvm787 cord-338900-8ojah695 cord-338668-z2z4gte2 cord-338729-v2suoj3c cord-338683-nzgnpi6f cord-338346-e3fk6gz2 cord-339406-81a7fkpj cord-339333-7tpnbr8q cord-338602-6n309bnp cord-338023-gb5jgqcg cord-338605-3i5pvcgu cord-338131-6y96eyoq cord-339455-b8nu34vv cord-338600-wpfcxnyu cord-339267-p3djwg7v cord-338182-cetv78ba cord-339467-ewqxf02j cord-337965-z39q8ebq cord-338419-n8cmv8mf cord-338965-ewuqsfsf cord-339266-glmshsh6 cord-338756-jzz250o1 cord-339517-93nuovsj cord-338741-gy3ovkrt cord-339568-th2xmhb6 cord-339436-0k73tlna cord-339474-tsdq1rgz cord-339737-7qdjea6f cord-339940-80757pwu cord-339811-dms0rlmr cord-339589-dl2qpc0t cord-339009-wcoch07b cord-339044-qy4jab37 cord-339355-zkkj8a83 cord-340051-r9kn34wd cord-335802-1kiqfy68 cord-340164-vzdyy656 cord-339705-x8l3zgfd cord-339956-o5o2yz1u cord-339686-oybnk1j8 cord-339885-mpzgrogd cord-339656-u0cpklsv cord-339504-8svo2w3u cord-339695-3ij5pjjy cord-340204-3gm58qza cord-340232-cadu5ah8 cord-339913-ps4nvvaz cord-340415-6fte7krp cord-340650-mwsa326c cord-339679-9hghy9pd cord-340000-1e66aqih cord-339471-1510mzmy cord-340576-dabcs3w5 cord-340799-1awmtj52 cord-340826-2530zdeq cord-340687-99ad1rwq cord-340536-azlajqbe cord-342555-5r9aa7u5 cord-341202-1pg7rq2d cord-339614-28s205p8 cord-340070-de7sfccy cord-340314-5oz3013n cord-340383-psjga23p cord-340542-jz7ca041 cord-340880-2qop8tcp cord-341627-21m8rdhy cord-342810-41dghl0c cord-342246-tnjtd9n3 cord-340710-dmow5p7k cord-341197-e8m4oxma cord-342303-ddulfe06 cord-340253-lpner9f8 cord-340660-ocvy1ge2 cord-340984-blkhfhe2 cord-342857-vj6sw2ne cord-342139-t2tukk0z cord-343052-dc9s2rau cord-343201-98scxky8 cord-342519-tjr6dvtt cord-340857-teq5txm9 cord-340430-x4oitcyh cord-341314-1mav631s cord-342569-ja96xfns cord-342808-yonbowkb cord-342841-b1rucgmg cord-341359-c34gyuv6 cord-340651-g3518bq2 cord-340786-12vzsl6p cord-340766-aic570x8 cord-340811-w4x4falm cord-340908-8q7i5ds3 cord-341415-g781zhu6 cord-341118-h5t87vf8 cord-341531-w788qwya cord-342068-zhk3wmou cord-341933-dwki1hwu cord-341284-jmqdnart cord-341234-2zgfcrwc cord-341999-nosdj7b2 cord-341076-ox2ckhqu cord-343308-5i31ysee cord-341670-o1v63zg8 cord-341591-ib8lsvku cord-341919-8gnthufw cord-342786-dl8vjwfn cord-343743-6k3soh1l cord-342809-wrxejwms cord-343490-94vkfrtw cord-342979-pvewvmmf cord-343393-8hdygwip cord-342930-f7cw2ca6 cord-343023-e1uv7t6p cord-342451-yfy5jcw6 cord-343452-4m0ub9iv cord-343715-y594iewi cord-343773-9f7ew8uj cord-343819-1uki4b3d cord-343973-n5ogyxz7 cord-343876-2inr4mcy cord-343797-kpmz5kwg cord-343917-67qjqxqh cord-344004-z7pn7u6u cord-343877-jzkaee16 cord-343443-ljehete1 cord-344185-jz6ui4w3 cord-343897-f4imrltt cord-344117-lr6roxej cord-344104-592r71l1 cord-344135-pyibu6rj cord-343970-anocx4y1 cord-343566-epvswt7f cord-343832-xg3swuzs cord-344270-874i31h8 cord-344131-e7phs0jd cord-344271-5aynmdsk cord-344389-aj9q73f0 cord-344120-7t5ce2hb cord-344191-veug3dae cord-342603-k0f33p3l cord-344017-qldawc8m cord-343205-zjw4fbfd cord-343437-cz1w9od9 cord-344302-p0v6sl9x cord-344668-9m1vnpmo cord-344508-a67vsux2 cord-344431-2wq7msqz cord-344709-5hy1e4t1 cord-344486-iu5flbcl cord-344765-agt60ksx cord-341063-3rqnu5bu cord-345381-9cckppk2 cord-345028-56hg62be cord-344939-rgxqobfw cord-345445-9t1vebey cord-344729-sjjedgws cord-345628-a4c46m2w cord-344693-znw3dru4 cord-344853-s2p2csrx cord-345296-4z7yfj5s cord-345517-ji4cet51 cord-345632-iha2c5zo cord-344967-t88pedeb cord-345779-frspku51 cord-345611-xv62h83a cord-345680-10phij1x cord-345655-fb4vv4my cord-345860-d02x3151 cord-345371-pjbviagq cord-345092-1ztfcpsb cord-346061-pbghgitg cord-345762-khvcoqti cord-345044-2fez1gu0 cord-345727-bcxkycjh cord-346241-w076l97s cord-346062-q0trgj12 cord-346276-1dcp05rd cord-346288-9to4sdfq cord-346607-1mewok8l cord-346345-jc9bq0zu cord-346987-fbqqf00i cord-345546-v7t26oos cord-346459-tkt5ldyo cord-346389-gbmnoo84 cord-347091-wbjpa5st cord-346594-tbsxgz43 cord-346894-iy35298o cord-347105-my9nioko cord-346664-ilebaqx3 cord-346496-crhv0gnt cord-347268-vb6z0hzb cord-347255-fl9lur4h cord-347064-ljd121no cord-347058-kejcwlng cord-347293-fp8phk0p cord-347696-rsjwp0b3 cord-346015-bzeqs5oh cord-346721-l6y3n21b cord-346616-kr500kgj cord-347375-5ucemm87 cord-347280-jpwf55l6 cord-348051-o1hxoasp cord-346205-vqgcq3qt cord-347351-emdj66vj cord-346558-u1e0kzmm cord-347289-3yi5tz04 cord-347607-ydbyonbg cord-346539-kxnrf5g5 cord-347277-8bmcd22v cord-347121-5drl3xas cord-347905-w0fnc43a cord-347238-yacn6xqk cord-347414-t88654wo cord-348202-6we8e60b cord-348422-werg9ofa cord-347697-uz0i6wfp cord-348501-8cvtqj7w cord-347752-2ejnva4u cord-348458-dwj90mbq cord-348881-w0moe21t cord-348172-q3zcn5pf cord-348672-e34103b1 cord-348975-plne3xlz cord-348430-8xk4dt7t cord-348423-zq86ms8w cord-349031-tbof9yqi cord-348855-lnltoj1n cord-348570-plds5kbn cord-348578-chfb4i15 cord-348813-v1sdodz9 cord-347263-ci6mv72z cord-348879-opzkodt7 cord-348755-2g5gi1du cord-349144-cvmebr3f cord-348130-t9tysvr8 cord-349280-12hc3mhq cord-349263-mmfrqyrc cord-349329-f0pbd968 cord-349210-8t4a5qqo cord-349500-603v8lfb cord-349533-51cex2sl cord-348364-jb0lvhq5 cord-350052-9431xqu1 cord-349565-g1emvmdu cord-349396-a6zyioc1 cord-349566-zx9kt144 cord-349678-79zlgjqi cord-350232-zml4o93t cord-350065-frg7gvf5 cord-349958-126yb5se cord-349740-xed4aybr cord-349838-p6vfzbla cord-350166-loxe11d6 cord-349949-jp0hvcg6 cord-350437-dq1il88y cord-349561-4mkiwg9k cord-349360-dv4lxx52 cord-349076-x3rjasg0 cord-350131-rsrlri8m cord-349439-3z0b77r5 cord-350325-vu8v9epr cord-348535-tvs1snq8 cord-350408-rqlkwoya cord-350179-ltk5hfc4 cord-350401-suefuurq cord-350529-yqtu059x cord-350338-lcsa06gm cord-350594-0zxq4lxc cord-349775-zwslhjju cord-350990-tywbe4o2 cord-351224-jeedo5mc cord-350737-nrtrhq1f cord-350589-h6hotlqk cord-351195-2fdqu2l1 cord-350904-wyg8ikph cord-351446-j4ambec5 cord-351223-nnuoadh6 cord-350200-1w5u3w8i cord-350923-532lnnll cord-350578-wyz5jyjh cord-351184-kcc3p3ow cord-351046-yq7287k9 cord-350639-iguadmw1 cord-350959-bsbz3a1l cord-349408-2ser9zjc cord-351129-lzzyn570 cord-351457-fzj3ciif cord-351340-7y19ystp cord-351528-23lbs8al cord-351155-5bvo66yb cord-350718-jzliir37 cord-351531-wo1ggmmn cord-350679-69lv4wbz cord-351020-wde3ki0k cord-351625-1we9wi1g cord-352193-izzqdg3v cord-351825-fdog73g2 cord-351896-j6h02ab5 cord-351555-hsgsuor2 cord-351762-n95ar9ci cord-351776-otx5qwyu cord-351604-x4rsdwqz cord-352065-960xqft4 cord-351722-3mw1te94 cord-351823-ldbscq4s cord-351735-x1lng449 cord-352234-utjne1ef cord-352401-tmt1pmw9 cord-352302-are8vvhh cord-352177-05sku8a8 cord-352304-tt2q5mgs cord-351819-ovpz36e7 cord-352159-qx16i7s1 cord-351431-xcqz9d3t cord-352227-827987jf cord-352544-7b6btzrx cord-351597-bdazrbsz cord-352215-dhkvh45t cord-352846-p7hhv297 cord-352579-ndcbmgfj cord-352828-4ecik6xw cord-352399-2xfzpw9m cord-352823-1os3kwp1 cord-352901-ia34l2ml cord-352914-jccxzit1 cord-352577-h3652seb cord-352557-l7sahv5t cord-352969-rpt7xja6 cord-353013-7cx0gnum cord-353059-39msyuxb cord-352937-htmp0avc cord-352905-ge3u32hm cord-352889-fl61z3w3 cord-353180-hbwrzm6s cord-353256-7nfklun9 cord-354127-sb8tovy2 cord-352678-8f2ygul2 cord-353228-fxrf5wsp cord-353281-leb7c7b0 cord-353004-ocnp758o cord-353375-92pu0pp0 cord-353484-q7d0ysbo cord-353200-5csewb1k cord-353648-rl9dts7l cord-353671-xjpzhsup cord-354223-0ckpz0bx cord-353956-gjv5cg3k cord-354103-4dldgqzf cord-350571-6tapkjb6 cord-353786-284qn075 cord-353987-hj94a04i cord-354372-vfvnjmv1 cord-353340-l0icku0i cord-354160-sca9bgeq cord-353293-vjdwh19x cord-353698-gj8sx3zy cord-353697-ocxextfj cord-353401-y1mxnth7 cord-355003-1o2midnh cord-354204-23xkug85 cord-353594-z1vxamvp cord-354373-lldfoptb cord-353599-cw29edwr cord-354658-v451z3jq cord-354619-pftjhtpo cord-354168-omen8vvq cord-354411-4emzxu09 cord-354194-hf5ndv5f cord-354597-xubsodnk cord-354720-fu19u2b0 cord-353824-0oyvia6d cord-354689-dsv63it1 cord-354216-4khdcjed cord-355028-1x7w1749 cord-355039-qi4fwqbc cord-354337-a70avg2x cord-354749-zkgb16ae cord-355264-ygzh8von cord-355533-5kgdg2nb cord-355294-gifsqph6 cord-355524-qx396wq1 cord-355146-6rat5j64 cord-354824-7fdcu2f0 cord-355504-zsyvgm9c cord-355528-y4a1g6km cord-355031-l0tj7kp2 cord-355431-efwuy8p9 cord-355033-txxylmrw cord-355191-jghvq3cy cord-355898-hlkwwaqe cord-355885-pg6mpuk5 cord-355549-6xnjj5h5 cord-355484-2igc5wzx cord-355190-ytdw1d5v cord-355384-qa7grviy cord-355177-62v1qhia cord-355558-r6r1t47c cord-356040-qdpkidn8 cord-356195-5pcaxpp9 cord-356371-w9ejgzvu cord-356127-xy5tyd7t cord-356332-t0ahmh0h cord-356349-ey5vnddu cord-356215-0nypfw48 cord-356379-e8ohc25w cord-356056-82bvcuvd cord-356084-621qzpqd cord-355589-3zdv9zim cord-356246-4p0ok1mc cord-355296-46jf56nc cord-356057-87kxlqdc cord-355038-o2hr5mox Creating transaction Updating ent table ===== Reducing parts of speech cord-000001-ug7v899j cord-002782-mena480g cord-000308-cxr1ul7q cord-001313-f72hl6du cord-000831-zwfxnd7r cord-000229-9fr0m92p cord-000716-fhm8abxp cord-003533-8m0vyxq8 cord-000284-00rk8fb5 cord-002240-38aabxh1 cord-004379-91a7sgir cord-002977-o0dvwzxk cord-002514-pp06m5xk cord-001421-6t5puo6p cord-002294-qa8e90qv cord-000522-d498qj2b cord-000457-e50a0suk cord-001322-7xmxcm35 cord-004986-en7taikk cord-003404-eqgc8v7y cord-003828-bhfghcby cord-001617-ff3j7i7i cord-003520-f3jz59pt cord-001661-dj9bxhwb cord-004310-hl7fa4af cord-004342-9uok77wb cord-004147-9bcq3jnm cord-003701-i70ztypg cord-002956-e5ihpe4i cord-001879-bn7h0kcw cord-004404-s6udpwxq cord-003291-zuqx6ksy cord-004096-obrq7q57 cord-004314-gtwtakpr cord-001154-7k59ogn0 cord-003798-nki2sasr cord-001078-5m29nugu cord-001493-3yu2di1g cord-000161-hxjxczyr cord-000904-g6ffaer1 cord-003219-iryb3v0z cord-000891-5r2in1gw cord-000268-480d3yfv cord-002145-yq7iwp42 cord-004450-daxz9yhp cord-005425-0hxow3sj cord-003198-1kw5v6rm cord-005496-cnwg4dnn cord-001293-dfaxj3bv cord-004636-t6qldq3s cord-003011-vclnb0eh cord-003686-1pfk4qve cord-003446-yp5d29fk cord-004532-flo9139j cord-004646-zhessjqh cord-002853-vj8t28hn cord-003376-2qi4aibx cord-004464-nml9kqiu cord-003832-q1422ydi cord-004263-m1ujhhsc cord-001536-ta1i0ata cord-004186-m817oudw cord-004643-uu4uipfy cord-002757-upwe0cpj cord-005420-60ie0pfd cord-002724-gtv9syzi cord-005452-ouookpd8 cord-004949-icsey27p cord-003615-vpzzsdld cord-004515-x22q1f21 cord-004339-7nwpic3d cord-005503-hm8tvkt3 cord-002626-jzwwses4 cord-005481-00rezmqj cord-005606-c8c2rfzi cord-005697-l1zmrq4p cord-005587-8iwsvku9 cord-005819-fp5khzd5 cord-005482-v5iayczy cord-005569-9d51l6bn cord-006179-7uv4yfv2 cord-006181-fkh2fzbr cord-005861-3k8h3euj cord-006302-pnnkfid0 cord-005705-j765ruj1 cord-005717-x7gsqlwp cord-006544-yr4u61qv cord-006545-c12m75gq cord-005692-n4vxazst cord-005795-sgi54hq8 cord-006841-3u56erru cord-006679-nhbofufv cord-006332-ikh45wuy cord-005808-w0763esk cord-006518-al94gxjw cord-006750-cg2i2bae cord-006394-ucthbqvt cord-006621-0fxpn7qf cord-006236-2gpwf4z2 cord-006523-zxn4oqly cord-006343-c0amee70 cord-005750-54hul2lw cord-006000-ekwpkzqv cord-006344-de4dhv4b cord-006701-q8qh1kas cord-006363-xov4xwpa cord-005992-mu917isy cord-006563-qmigctkp cord-006714-q7wy76e2 cord-006426-baf2d47y cord-006517-845w9r6l cord-006464-s8rjoyse cord-007575-5ekgabx5 cord-005953-5z89yeb6 cord-006768-r2pa9qw0 cord-007567-vst954ef cord-007009-4wbvdg1r cord-006595-brpngt14 cord-007444-c9vu8ako cord-006508-rje9bnph cord-006226-fn7zlutj cord-006975-u5ecibta cord-007786-cu831tl7 cord-008672-luoxomif cord-006460-3ayc0hne cord-007563-33jxxp1b cord-007564-ljqrxjvv cord-007833-wkv808ix cord-007321-7gi6xrci cord-007580-qwh8ei60 cord-007865-1oyl6clq cord-006882-t9w1cdr4 cord-005487-vac061r8 cord-006856-b1w25ob5 cord-006862-5va1yyit cord-002774-tpqsjjet cord-005478-5iu38pr6 cord-006391-esnsa4u5 cord-008596-zhk82cor cord-009285-1ddfywfa cord-000843-e1bn79ui cord-007818-jfp9uumb cord-007788-09t52zix cord-005646-xhx9pzhj cord-006702-ekf6mja9 cord-007696-83v9yfa6 cord-009278-98ebmd33 cord-009891-gqrhbhbn cord-009360-rgwe2pkx cord-010116-hfzs16jh cord-006924-1i3kf01j cord-009507-l74c9x0n cord-006444-eq56zhtd cord-009322-7l7slziv cord-009417-458rrhcm cord-007577-f1jzbtjj cord-005480-yg7salqt cord-009575-bd67ph64 cord-010487-wncgecld cord-006828-i88on326 cord-010856-3g0123lk cord-006864-t5qsjyfi cord-010658-67k8pthy cord-007798-9ht7cqhu cord-006888-qfnukav4 cord-006869-g2q1gpp0 cord-009982-zgbu46fo cord-009667-8r8j0h08 cord-010261-sy7esszi cord-004675-n8mlxe7p cord-003532-lcgeingz cord-009512-o4y9s8zf cord-010078-8lkkez3n cord-005147-mvoq9vln cord-009697-dq4y89ab cord-005777-6rvfsx4p cord-010999-u2guhh3h cord-011138-y9v5ivzg cord-008695-y7il3hyb cord-010844-y26y5myb cord-011159-k2kca8zl cord-009788-bc6sc2rc cord-010036-6czkzek0 cord-010929-d598h08w cord-010141-955r29sd cord-010461-un9pls28 cord-010416-u0yo0lk6 cord-009967-fyqc5bat cord-010564-7c9h16bi cord-010786-w3kjc6so cord-010477-g754gjvh cord-010398-5wot7tix cord-010460-pczs9alv cord-011093-d9dbvbcy cord-001221-due9tloa cord-004894-75w35fkd cord-010921-yzv43e8l cord-010566-tciwtxud cord-011533-im78xwl8 cord-011360-1n998win cord-011413-yv4x8viu cord-011296-nutl2ovk cord-011181-9nvwk04v cord-011284-u4qmvz3c cord-005816-i54q5gsu cord-011255-9q2frk71 cord-009571-mygj2nd4 cord-006876-v2m5l5wz cord-011725-t1jl4cy1 cord-011712-fyrbe8tw cord-005105-twsy61oq cord-011349-bykvn367 cord-011483-zc6ve6le cord-011297-4um9w2dx cord-011975-8vl45xb7 cord-005881-oswgjaxz cord-009713-sxd4t2tz cord-011512-gw2sk90q cord-012025-faj682bp cord-011649-3dlsy8fl cord-012117-c693oefo cord-011221-rhyxp4v5 cord-012115-hpsxi9ay cord-011793-hlktpla4 cord-005497-w81ysjf9 cord-010075-72jodunj cord-011188-59hn9wsv cord-010933-xuztu95a cord-011103-sstpidvk cord-012459-tge08va0 cord-012037-9kmul7he cord-011327-zsoc4wec cord-011302-pfepyvaw cord-012665-fflye8a3 cord-010027-r0tl01kq cord-012778-yr8zuvw9 cord-011875-ga0dzj3v cord-013035-7sfj0czv cord-013149-y0dbhtef cord-012469-6cvu5umd cord-011836-zib8wkm2 cord-012902-efprpk72 cord-013003-gxd29jxf cord-013116-n7auvqh3 cord-013139-b32xg7y7 cord-013105-tmhce7p5 cord-006182-kck5e1ry cord-013370-gktnz644 cord-006880-9dgmdtj8 cord-012934-c6pbr64i cord-013148-qbxbndsl cord-012560-p5s0p7fd cord-013589-3l8kar3k cord-014833-ax09x6gk cord-013457-rqon1adg cord-013380-1jwzbgwb cord-013558-0sa63lp3 cord-014933-3jezc081 cord-015335-l0kjxhd1 cord-000083-3p81yr4n cord-015162-6be21d59 cord-014965-efmozngq cord-014980-cz1gx9oj cord-015930-18qznqp0 cord-016237-sk1wzghx cord-014540-27hnlu5v cord-015946-biu5zxd1 cord-015884-mtpbzgr9 cord-012518-ncrdwtdg cord-014987-nycbjqn6 cord-016248-dxk0i6t7 cord-016208-u12ngkpc cord-010088-s9tfvtao cord-016211-8j8n9enn cord-016135-44pgjah8 cord-015640-zdwmxaz3 cord-016601-gp259urb cord-016110-mlwe7fzz cord-015090-n6f4xupw cord-015389-vwgai4k9 cord-005727-li8pwigg cord-009664-kb9fnbgy cord-015082-l629n8is cord-014712-5u4e00q6 cord-016280-d47e3art cord-006466-e1phpqes cord-016301-vqmqnipq cord-014670-e31g8lns cord-006860-a3b8hyyr cord-015569-vy49r1zd cord-015922-5wwy0m2k cord-016498-j72vrvqf cord-016127-tbot0fc9 cord-016105-jkaxemmb cord-016460-39yniw0t cord-016871-1mlamf20 cord-016413-lvb79oxo cord-016235-2lhrkmrv cord-016300-vw11c2wt cord-016177-fz48wydz cord-016572-6fu5s89c cord-016308-qzkcwrit cord-015365-iqdi99pd cord-017105-mljywm9p cord-016521-ouwwkxox cord-016757-3d320c0a cord-017252-88b3preq cord-016476-78r0rsio cord-016814-tf17dpo5 cord-016973-s32jp0ej cord-016372-opojt70e cord-017012-yl0vanuh cord-017227-66dx2dkv cord-016559-tqd7m2i1 cord-016478-gpl0zbvd cord-017040-4zajnrsf cord-016982-qt25tp6t cord-017217-zjab7o2o cord-017142-vx3rgs4r cord-017350-rwqaw5ii cord-017302-xez0zso3 cord-015372-76xvzvdg cord-016960-xhzvp35g cord-017324-l3d3t4wh cord-017337-vq3edhxn cord-017374-clctlm5l cord-017392-ja9b5vy9 cord-017531-fm8gl5b3 cord-014538-6a2pviol cord-000977-ka4261wc cord-017489-ftz9190a cord-017420-tjwxec77 cord-017393-kx8kmdej cord-017534-0ai8chbu cord-006870-f5w6fw6q cord-011062-ukz4hnmy cord-017518-u2gsa4lg cord-017461-xw02c7u5 cord-017569-fv88n70v cord-017016-twwa9djm cord-017516-qbksb83c cord-015334-8p124rwp cord-017772-zpf1xjqi cord-017309-pt27efu1 cord-015370-4jfgsic7 cord-017715-99ri6x0y cord-017581-6lubp7io cord-017617-13m7pmvq cord-017883-6a4fkd5v cord-017897-mbwm0ytg cord-017815-0t7jvvz5 cord-017862-9fkjjmvf cord-017784-4r3fpmlb cord-018005-53cl75gk cord-015126-cyhcbk1j cord-014976-546zaoxn cord-018182-lleti89n cord-007890-bie1veti cord-017946-fa4ehlb0 cord-018209-v2crgj5w cord-018110-mcw4v13c cord-017799-2nvrakbs cord-015348-qt0worsl cord-018106-5giapmcf cord-017786-kfl6xt31 cord-018363-qr1pk78u cord-000718-7whai7nr cord-018318-vzzrsqsn cord-018408-ttae193b cord-018590-rkp89dqo cord-018545-fk17n2bx cord-018243-hyvu9nuq cord-018303-dvuwhpyq cord-018412-kv3vxmcw cord-018225-dozmy3lb cord-018447-z4jyjczy cord-018454-sy21cpff cord-018414-6ffhm895 cord-018623-of9vx7og cord-018620-3kqx8arn cord-018595-x3tleomb cord-017184-1ewi3dka cord-018801-amet0wx4 cord-018638-4pyjhpbk cord-018430-u3k8pds6 cord-018780-zeok60hn cord-018809-3nrvm4jt cord-018907-c84t1bo5 cord-018834-4ligp4ak cord-019046-q6uv2ayi cord-019010-9xgwjvsv cord-019027-6chba2ru cord-019043-cqmqwl3i cord-019968-o5bdb37q cord-018714-i291z2ju cord-019064-e5z92vg8 cord-021713-e0hzcag6 cord-021721-80pp1ra4 cord-018601-mk66097y cord-018840-ts2g1ux7 cord-019964-9leljj8j cord-015369-72cjogxz cord-019063-mcxbl8mv cord-021742-sdz6d1r5 cord-020342-u8jzmloq cord-022050-h24f0fpd cord-021701-yan5q2r7 cord-014687-0am4l5ms cord-021917-z9wpjr0d cord-021816-gk8rwyq4 cord-022292-msz4au4b cord-022119-bzd9e1q6 cord-021905-fjcks7w4 cord-021075-8hba6au3 cord-022103-4zk8i6qb cord-015024-2xzc0uc5 cord-015368-a0qz4tb9 cord-022521-r72jtoso cord-022173-kb6mez61 cord-014533-6qfecv5h cord-021571-7kbq0v9w cord-023169-obupqcua cord-022646-f7qs1obg cord-022658-mq91h15t cord-022216-k4pi30sd cord-023622-tul7bonh cord-014996-p6q0f37c cord-015352-2d02eq3y cord-022594-fx044gcd cord-023311-7wqdlha4 cord-023033-tgt69ir6 cord-023483-owgs4syo cord-015306-us58wwmp cord-023669-3ataw6gy cord-014464-m5n250r2 cord-010980-sizuef1v cord-024233-hrzpxdh0 cord-023186-gqltd6u0 cord-006854-o2e5na78 cord-023873-fidpskcs cord-023288-sqr33y72 cord-023729-dipjubn7 cord-024130-kgzegwon cord-024614-6bu3zo01 cord-023168-cd7adns8 cord-023303-fxus38mp cord-024120-3eemj37r cord-024073-243addff cord-024956-oht0v33s cord-024893-pd67o7l8 cord-024795-xa7ke70d cord-023833-xpfibjh2 cord-025157-7b3v5yct cord-023306-3gdfo6vd cord-023308-af5nihyi cord-025749-mip9mkef cord-025666-u8w4sk07 cord-023302-p9pxz44a cord-027551-a92lv4sh cord-023305-5lb9kho6 cord-025172-qg3jxgch cord-023331-jrvmgnu3 cord-024833-e6vcf4un cord-027805-p0bhju1s cord-025990-nj4ah2yz cord-023314-rwjxk8v4 cord-026846-3u3x52f8 cord-025170-dtbm4ue1 cord-025176-f0frlpwh cord-026879-gwzrdeb1 cord-027266-jdti1pwa cord-023343-y17z9w2x cord-025164-hqj22yxe cord-026392-cvb44v5v cord-026991-75sbxnsc cord-026868-z9gozm2w cord-023298-ysur3sjq cord-022527-a0x6lws3 cord-028328-5lews3uw cord-027678-k64whepc cord-027259-f4sgobcz cord-028557-68jypaaw cord-022659-chwk2bs4 cord-026653-094bk0t0 cord-024189-t7mbsr25 cord-023239-06a03o14 cord-028260-mja2jrgm cord-028907-m9psxg1f cord-028709-r1inj3ra cord-023333-b7w9zrl6 cord-028285-n4dommet cord-027677-fc410vto cord-028982-kkzpqbry cord-028379-ghudhac6 cord-028590-rw0okd0p cord-029183-3aotgq6m cord-023509-tvqpv6fp cord-029211-6o7qn2y2 cord-009567-osstpum6 cord-029606-2z1tw4xo cord-029466-9sy6icrm cord-029612-cts1al9z cord-029626-j6b59y7a cord-029770-72ncfyc5 cord-029609-zh2ah34g cord-029615-x498xj3m cord-005814-ak5pq312 cord-029848-dj5xqlz1 cord-029547-9ei1ram3 cord-029859-fhm0d9t9 cord-030256-muah207b cord-030254-eevqclsy cord-029991-0sy417j0 cord-031130-xvkyt3l3 cord-031544-clzt6kyg cord-030927-wo8r8zny cord-029884-zl0uqmfi cord-029150-e242o2ml cord-030918-0w327dgj cord-023216-avn8f2w3 cord-029112-u507i0t0 cord-030502-mvlib8ol cord-006849-vgjz74ts cord-029332-yn603pvb cord-030531-4uucx9ss cord-031129-wqkdug42 cord-030149-hkpjnqm9 cord-023017-k6edtg58 cord-030897-c88tjrai cord-032588-8bfl2qy1 cord-027860-s97hdhh6 cord-032335-6c9gt7t9 cord-031710-1xl2isee cord-033279-bcf9568a cord-030370-89n13hml cord-030216-l38i06v2 cord-031256-4mxt501d cord-030380-okue1kso cord-030962-2xem8inu cord-026025-xqj877en cord-031558-8wysernx cord-034157-uif9xtvl cord-030361-0tepkjdl cord-032544-2yrqjw1o cord-022653-qa1uph35 cord-033247-2cbslnb7 cord-032928-m0awip9y cord-032392-ex3s8evv cord-033965-c1i7dnnt cord-033135-cxsmxk3b cord-031734-5wnvuk2n cord-031821-rywdkqcd cord-031191-63xtga7h cord-019490-m1cuuehi cord-033778-u2r0neyc cord-034257-kl2ccmz5 cord-033574-4y53ryoa cord-023913-pnjhi8cu cord-034036-1wigu3i3 cord-033327-yi1tvsh4 cord-032930-ohsh46l2 cord-031497-pp0p3en6 cord-034286-m1c98nv7 cord-034435-yp0gfl47 cord-033019-4eo037jp cord-034303-kcu9guxa cord-034371-j3xxmkjd cord-032244-s7t5u9lf cord-034690-x8lkngra cord-034746-uxhpufnv cord-103686-er8llst4 cord-034898-zjfhpum2 cord-035024-kx9jfssi cord-035067-ic843wr9 cord-030369-4dn02a35 cord-048489-ajafw966 cord-034185-e0am7pa6 cord-034578-i9rdubix cord-035316-l4qbiuuu cord-035030-ig4nwtmi cord-035026-2qcsfd87 cord-035070-drt6esrk cord-014794-yppi30a0 cord-104055-47ren7ie cord-035090-gnfeyddv cord-102199-mc6zruyx cord-102276-0a8hup5y cord-103214-3lz33pj3 cord-048343-nzk8m912 cord-104180-f3hoz9bu cord-035182-ax6v3ak5 cord-104507-xx7t26rl cord-035315-j5mknuv5 cord-184194-zdxebonv cord-214006-0w6bqrox cord-103807-x4hrwhkz cord-217201-lvefk7qx cord-104467-elwfz1gk cord-035396-lg7m9xzs cord-148109-ql1tthyr cord-032183-yqqqe325 cord-244388-dxrrpxl7 cord-034340-3ksfpaf7 cord-158252-l43ztxsl cord-204125-fvd6d44c cord-216974-0al3vdh1 cord-103659-wpwfqhp2 cord-252159-6t35bxwv cord-023592-w96h4rir cord-252617-rqm0p19e cord-138439-wvynetna cord-252829-gn56tsz3 cord-252473-i4pmux28 cord-252374-obl6pfpf cord-252013-ehyuflg3 cord-019347-tj3ye1mx cord-251957-luw8m3eq cord-252368-njlo6g78 cord-252506-8u9oiqoc cord-252279-0gozdv43 cord-252539-kx8ew3ap cord-028721-x6f26ahr cord-252288-klkoerfn cord-252284-cgdcsazr cord-252101-77lnyjan cord-252060-cotsu82v cord-252687-7084pfqm cord-225218-x32a4sp3 cord-252452-wwkw1uyi cord-104404-ytszpa4c cord-253168-b095rq5i cord-252531-i3b647wv cord-252085-8dq3gdo8 cord-032181-gmcugd8h cord-252243-ua2w6xki cord-253148-3t4o27xp cord-252699-0xw9xvox cord-253456-u9num2o9 cord-252751-prock3co cord-254148-wc762p6v cord-252890-of29g89s cord-252981-hywvmdjb cord-253886-4b3i30hi cord-254269-x8vpnhd2 cord-015021-pol2qm74 cord-253638-5f9ofdsc cord-015359-gf32a6f1 cord-253256-909chgl0 cord-253129-v5lck9l7 cord-253417-ihi67m1u cord-024651-578c9ut5 cord-254072-evgw0as5 cord-253189-uba6dy08 cord-253962-ug7yflxh cord-009997-oecpqf1j cord-253862-jl1zhg13 cord-253295-82ydczid cord-253077-61fmul8c cord-252775-faxiem2w cord-253704-y0t30xw3 cord-254446-yxqbe1dj cord-253375-m3qjj7r4 cord-253746-15w4gquq cord-253970-sbj869yy cord-254428-n0uwy77g cord-253402-6sgeraws cord-254478-scc9wee0 cord-254040-s3k51rkk cord-253730-cdkzvfib cord-254990-nrzwn6oz cord-255233-rvgj6pvk cord-254357-5s84kimn cord-254993-bndl93qr cord-254025-j1l0mder cord-255197-79yfslu1 cord-254852-qr5gdmbc cord-255300-btyth32l cord-254419-qw83atrx cord-255256-8uckmya4 cord-254382-xy8se56o cord-255267-o8k5ep9y cord-255490-gyq6cpc9 cord-255240-ltatgq3e cord-255393-aknebauo cord-026031-hnf5vayd cord-254377-j8e8gb0l cord-254777-h8hw4m9f cord-254595-by2j7byz cord-255746-ir73lpi8 cord-256109-dkp0fwe3 cord-256011-0cr4ejxu cord-255831-nrc35tug cord-256262-lwc4ghj2 cord-256051-87alqfkd cord-255519-tcobane8 cord-022650-phsr10jp cord-255037-i9guxtix cord-254494-wbfgrez1 cord-022501-9wnmdvg5 cord-023354-f2ciho6o cord-255435-mr239gai cord-256459-6h358si5 cord-255460-r5p5helx cord-255807-7goz1agp cord-256030-5xzuilc1 cord-256117-t9v1hng5 cord-256290-pyrmtps3 cord-256888-tdx12ccj cord-257035-ob1xncbs cord-256618-tt3p0tki cord-256508-ce59ovan cord-256535-fz5p2u6p cord-255805-wlr8nod3 cord-255652-3n2dxljj cord-255905-ti9b1etu cord-256556-1zea3wa1 cord-021206-4zyqqgs0 cord-257274-fzyamd7v cord-257206-av2k44ig cord-256849-8w2avwo2 cord-256639-4e0irb6d cord-023346-8sqbqjm1 cord-257504-tqzvdssb cord-256893-3sh87h2x cord-022633-fr55uod6 cord-257147-i48qljv6 cord-257276-h5542vqg cord-256856-jw1d6uig cord-257884-5exwwxin cord-257717-fbfe5vt4 cord-257600-0plhquk9 cord-258027-f3rr5el1 cord-256864-v3mxcwru cord-257344-d13at1y5 cord-258113-mnou31j3 cord-256688-yy7abob9 cord-023049-fio7cjj5 cord-023157-0lqlx2rv cord-257051-ntnfu5ns cord-258293-7q9zj8c2 cord-258067-par61wwh cord-257408-ejhhk1iu cord-257467-b8o5ghvi cord-258278-25rhf91v cord-257781-ybpliz32 cord-258548-1u7v1nlr cord-257839-kfzc4pwq cord-256634-gg8hptfg cord-021087-n4epxwn9 cord-023364-ut56gczm cord-258416-1jrbu8ox cord-257732-3xuy6tbn cord-257336-rpx71ww5 cord-257433-qgkwylmk cord-258093-6fn8ei9f cord-257729-s0vo7dlk cord-257309-sazs5wgh cord-258117-5gpo8smn cord-258708-da6x5rxa cord-258583-5qdthy0j cord-258727-mhg56j20 cord-258576-ywbyflas cord-258888-amimzjee cord-258692-dch1utis cord-257696-ybu772zw cord-258758-sz8chn5e cord-258315-yt1ytasw cord-258402-9s57thvn cord-259801-xuvcrvo2 cord-259229-e8m8m4ut cord-258133-zsweppku cord-259448-deya8dwn cord-258128-qtmjgrml cord-259699-48jg7ci7 cord-258916-jbdz1pk0 cord-258930-60yn4hg7 cord-258498-0mvxwo3w cord-259767-x9s8qprc cord-259204-27t269pd cord-259984-csdf1a69 cord-260105-ckh8jp9e cord-260456-kjmab3og cord-260503-yq4dtf8n cord-259969-q65k590s cord-259747-sl9q63oc cord-259073-dixskemz cord-259907-yqmi0cqy cord-260525-bohv78hi cord-260215-gsnjlhjd cord-259585-mjtxiu0t cord-260037-ys62jrgw cord-259329-8pta6o6a cord-260083-c1r9zn43 cord-259411-434acu0h cord-260180-kojb8efv cord-260630-vvpzp73r cord-260700-u12aa739 cord-260232-98gtlad6 cord-260274-c3586tp6 cord-261062-9zhe3ejy cord-260679-tm1s6wvj cord-260605-smkr7b15 cord-261006-2xh3f07i cord-260762-1kuj5dzz cord-260224-1aeqe7fh cord-260980-tyf3fuz9 cord-260981-647wfa8z cord-260871-dtn5t8ka cord-259848-0thzmh7k cord-261410-kb91eagd cord-261151-27ocvgnw cord-260854-v7wgb6mr cord-261383-izd1vn6f cord-261470-sqxdwu6j cord-260119-pgu2crhs cord-261485-0ke5nqy0 cord-261801-va2e029z cord-261025-y49su5uc cord-261246-m40kwgcg cord-261311-j6bmgmhz cord-261380-xms5su6w cord-260857-oxxle915 cord-261980-bm0benu2 cord-261921-c97ygxq2 cord-261240-osbk041e cord-261670-rd9uq6tc cord-261736-jlwctmxw cord-261856-i1e0uj0s cord-262412-bs7quwov cord-261455-uejtwgar cord-262236-1lilrqts cord-010092-uftc8inx cord-262068-9ixq8hwb cord-262454-bccrvapy cord-015354-yknwveyz cord-262339-e2ayh108 cord-262626-yk4e737w cord-262150-j72jbohi cord-262824-xgf5v1ok cord-261941-xf1k5uj1 cord-015324-y44sfr0c cord-262796-syu4wbpi cord-262729-qcijsyo6 cord-262780-ilu5oskk cord-262708-hctuxrw9 cord-262467-epqqd8n8 cord-262954-saqo900k cord-262518-a2ql8hib cord-022888-dnsdg04n cord-262551-hxhlhb5m cord-262928-l2bqcd0l cord-262973-mydn7ver cord-263061-ocplcdiv cord-262784-r9gq2oan cord-262987-7h91n9ro cord-262998-cugd2t1l cord-263055-4f25h9l4 cord-263292-qjfe2t9v cord-263214-h6lkvlj3 cord-263285-89zqgqx1 cord-263064-n4c0m5hn cord-263716-ywsm11aw cord-262878-ygvbqmxd cord-263031-cco2vh0f cord-263046-3aerbonz cord-263599-cqol8zf2 cord-263691-ovsi38bx cord-263191-osa3ylkl cord-263530-t9ryky6f cord-263883-7ba0huwy cord-263241-qzerj9bs cord-264327-uzlavmhx cord-263882-s5oxr6es cord-263066-umvojci8 cord-264073-yhztrscf cord-264180-0vd3tr9j cord-263793-bmadusm6 cord-264122-n64tm6qr cord-263908-4ti8l2ea cord-264368-p2fwuh0i cord-264751-2l3cqhe2 cord-264673-67zopf7s cord-264647-9r443j3l cord-264295-7ojvhwb0 cord-264449-p3tgjuj4 cord-263628-ac9gld5l cord-262766-ndn6iwre cord-264504-nnvof29x cord-264889-1vsvcza2 cord-264042-4hc2i25r cord-263294-9r84f19u cord-264829-ynel6ore cord-264543-b4zwinh2 cord-264843-cwtdkylo cord-265052-hfuvm1oh cord-265799-qda5awuc cord-264779-71s7e18i cord-264972-hrbo3awj cord-265053-x70501t3 cord-265721-wmz3wywi cord-265111-d44ireu5 cord-265082-gjbabh4g cord-264924-ds6jv5ek cord-265098-u5qssib9 cord-264952-0t0t4x0y cord-265278-wf5pbvvt cord-265230-ozyx8u64 cord-265967-y4639p9m cord-265818-wme1360n cord-264610-kxebc12r cord-265812-1hcp36cw cord-265022-p5cab562 cord-266010-ectnfv5z cord-265934-wjdxqj8h cord-266456-10tjzqep cord-265262-r01u4jr6 cord-266294-ua22udlc cord-266255-898h9rl1 cord-265472-b1s4stvz cord-266079-nv28ppft cord-265848-afkeuwup cord-266469-n484zqq1 cord-266214-l8pmhcd5 cord-266583-avhiqlgy cord-266463-ci0g1dno cord-266429-0xaz8kbs cord-266722-qfn2dc1q cord-266775-4npowkkz cord-266450-g9vihgbk cord-266160-464v4g8o cord-266730-mio282vy cord-266478-642m488a cord-266750-41gth6o0 cord-266455-rbblg4pu cord-266475-t04pukea cord-266744-31p212aq cord-266905-j9ljwqv0 cord-267020-4mpc246u cord-267124-8efdzlc0 cord-267142-ys7z7j8j cord-266932-567lbktm cord-266512-xh6zed03 cord-267287-qodj254z cord-267621-oc8bw7ft cord-267357-7aap2cte cord-267525-tg4uwent cord-267041-i94lyfsh cord-268049-7xqln70d cord-268155-b8lqo52f cord-268168-yzvag38x cord-267300-zbipv9er cord-268140-s5lailkp cord-267788-ukz2wz4a cord-268347-xz6fptol cord-267947-dnv2xl0h cord-268254-1mg7a17c cord-267402-kca05rvz cord-268455-btuzihsy cord-268252-6g0vbd08 cord-268211-egy8rgtl cord-268632-p1rsz8fk cord-268324-86a0n0dc cord-268540-wrjzr3ws cord-268561-vq1uhj5i cord-268531-igjeai8c cord-268879-ajd7ofc8 cord-268326-sbz3uk5h cord-268886-mpceglk1 cord-268617-1t7yaoct cord-268952-3j43p9j3 cord-269051-nl0jfqxt cord-268843-zml9lbve cord-268939-ws74xprt cord-269087-f9hyntvf cord-269031-sz8ieltb cord-269099-q5nyzlhs cord-269280-1zbxjmxu cord-269009-0i2bvt77 cord-269564-r5mmsnbx cord-269289-6uog10j4 cord-269205-g6eyvnou cord-269190-w74bjtq1 cord-269275-b7xxk48t cord-267132-nb0j6k3h cord-023211-kt5gt26t cord-269105-yuphgyrn cord-268974-7bqh1yas cord-270019-er70ehk4 cord-269345-5tlyy8jp cord-269425-e9iyso7n cord-270079-vwnzp6zj cord-269554-fzu6dy4e cord-269469-7pmnxi9a cord-005460-ezrn8cva cord-269690-6r2bfydw cord-269503-ij4u980v cord-270294-g95skuik cord-270153-krhkqcev cord-270509-roc93m4f cord-269591-lu415jcp cord-270348-5804ffwx cord-266713-rghowch1 cord-269981-xm0by310 cord-270124-tqhkzd2w cord-270210-gfy2ytg5 cord-270327-v4td3zsa cord-270525-nmebqrb1 cord-270391-703js942 cord-270388-nozh463l cord-269835-mz7i66qp cord-269511-bfd1dmt3 cord-270712-v6nnnzhm cord-270776-oulnk1b3 cord-270665-z4l3lq39 cord-270654-cz2y6ta9 cord-010119-t1x9gknd cord-271603-zy4l9vtf cord-270245-zziwb2jy cord-270763-idkylpb6 cord-270723-cjfglili cord-270876-kul6bs3w cord-270740-3su8pc3f cord-270933-ecmg8kti cord-271358-5666nsb9 cord-271180-cnrs0zpg cord-271149-qnhlfozo cord-271220-sntawlnf cord-270628-jtj30v0r cord-270799-2pmpspuj cord-271262-xglhx928 cord-271887-blwrpf38 cord-271212-y8denvju cord-271871-8grkln6o cord-271660-5sfkhg19 cord-271920-1dzkgt6w cord-271896-1ad18z11 cord-272427-jqs00ilp cord-271944-oxtus5vb cord-272143-6ej3eibd cord-272553-bcmta2he cord-272318-8yfg1j0o cord-272727-a5ngjuyz cord-272071-445ivhx0 cord-272585-346ef6qy cord-271483-33kuvpl7 cord-272419-y3ebt4jm cord-272154-nrm9ulj5 cord-272135-a09bf50o cord-272112-egsha2j7 cord-272655-qeojdpez cord-269776-hj1s3ipp cord-272975-gzsd4ybt cord-273090-fdzkfo1u cord-272630-2na1gndu cord-272677-6t9kl3hq cord-272778-aixiioii cord-273045-ele1cz86 cord-273426-55vu6b3u cord-272976-pb2bjpop cord-005453-4057qib7 cord-273641-8l57mnjt cord-031907-ilhr3iu5 cord-273091-40gda9n9 cord-273602-cq276tj8 cord-273119-jfy0iviy cord-273869-buavj9mm cord-273283-gb0m6fue cord-273175-bao8xxe2 cord-273567-8fp3a9h8 cord-273875-vpp0l6ij cord-273929-kpcmy9x8 cord-273695-p5p7kvpp cord-273408-jtpaue0z cord-273587-nja58vxw cord-274199-3stjueja cord-273614-qmp2tqtb cord-274184-hm516x6p cord-273913-xem3alih cord-274250-95yzt1gj cord-273317-2e3vmdx4 cord-273758-hhd8xnve cord-274481-k1dp1ilv cord-274542-fpzk5k79 cord-273945-b1lekw47 cord-274008-p3st70u3 cord-274494-heu6rmbt cord-274632-d9z0m2l8 cord-274557-2071770h cord-274245-pgfqkwqg cord-274331-0i2opmcn cord-273996-z5vlw6nm cord-274782-yymo9i6r cord-274563-jimw6skv cord-274556-531jlpwr cord-274121-3w6kc0c9 cord-274779-0emfl1e5 cord-275041-fcdwitxy cord-274355-6hiutrct cord-274666-0d8oz51l cord-274934-s8xppipe cord-274324-obhrbxu4 cord-275110-safr9z37 cord-274860-7ec2jcoq cord-274802-7ioiwsd8 cord-274282-hvx5m2bx cord-274871-jlquvz51 cord-275257-upj8mvzn cord-275185-9br8lwma cord-275260-xuhxqkyj cord-275518-p03sl946 cord-275266-e6omvo5x cord-275214-mqvw0219 cord-275004-qzg03dvg cord-275477-blu6wjhu cord-276249-9opsg7p2 cord-275349-b35pt3mo cord-275154-vwnpred5 cord-275340-q8d7rvnj cord-276241-4g6pa7kz cord-276132-tv5y1eqc cord-275440-fl4dsu7d cord-276264-wgzh3f5m cord-276288-upv2o8f6 cord-276090-n8c2jpr6 cord-275272-qdg8sqpy cord-276267-77903fld cord-275979-cx2h5bsw cord-276359-syr9av09 cord-276234-2nkeq4ud cord-276524-th6eu11h cord-275506-3t5gf66c cord-275742-7jxt6diq cord-276438-nynri6my cord-276405-yfvu83r9 cord-276495-q22jnkn2 cord-276635-0ciy732e cord-275913-85u6v3ib cord-276676-lgt0rzob cord-276343-sb3vd7fq cord-276327-wyevh4xv cord-276303-lgywz9ea cord-276621-9exp8e7h cord-276856-88d3vzbs cord-276927-rxudwp2v cord-276782-3fpmatkb cord-276784-8lmg97zc cord-276834-20lcihf4 cord-276592-dsilwfl1 cord-277189-fe8ego7f cord-277148-xzpuc22p cord-277096-zvb7n9wo cord-277260-7se220oz cord-277014-iz8jo44e cord-277328-9s8fwg1h cord-277539-xt2nt11e cord-276641-40r4mitg cord-277535-u283k70i cord-277201-jzjxsetx cord-277146-4a4vz36h cord-277498-hdhq99k2 cord-277207-2my86ums cord-277576-3dvt6uj7 cord-277700-nxm1jr0x cord-022940-atbjwpo5 cord-277399-0w8is9xm cord-277430-x02u7oh0 cord-277178-nbotxv35 cord-277486-12uah5qi cord-277323-jqr2hkv2 cord-277210-xaj2623u cord-277803-7p1qu2rf cord-277818-8w15dz20 cord-277811-j58qvyum cord-278325-ykcd7d59 cord-278477-9a7gmzz3 cord-278300-6cr9h7no cord-277889-8u685f45 cord-278549-br9rr713 cord-278364-58d8kfdf cord-277739-eb4z3u66 cord-277992-49mantab cord-278547-y0hvq0qf cord-277643-xh8z9v0m cord-278937-lkuuftno cord-278943-f80ucqqp cord-275828-c6d6nk7x cord-278332-fbksw3om cord-278672-pxzsntfg cord-278106-ev1nx60h cord-278682-s4gfbsqy cord-278984-0zof6s4d cord-278319-44bvju3g cord-278993-w5aa0elj cord-278536-b4eyegx5 cord-278592-67y4f9av cord-279134-s6c7m94h cord-279158-dsnniuo6 cord-279052-8hxdfdls cord-279111-jaa45kyc cord-279435-ffgd2ets cord-278838-qraq5aho cord-278256-dmrtsxik cord-276758-k2imddzr cord-279299-5djtiomq cord-279456-oouylyx9 cord-279357-83hisxro cord-279056-mmcoqtb5 cord-279557-hk77e3pp cord-279480-nqp1pc9v cord-279238-d49jvws2 cord-279197-cesemos0 cord-279550-7u2hksxm cord-279667-ikfduu2k cord-279570-lgbqpfh5 cord-279513-m4jdc8ua cord-279396-qmixem8i cord-279846-g0ro8pbb cord-279571-chiadufa cord-279732-cea0nt8z cord-279790-zzvetjrt cord-280070-c1bkhgaz cord-279719-z0wuajpx cord-279483-gwikyux2 cord-280129-a97rvtzl cord-280097-f7ky61ds cord-280278-gq1hnnwh cord-279736-udsbcqfs cord-280005-i9fp5rys cord-280507-1nf2ycp3 cord-280628-ok62havd cord-280280-9jr7ekbu cord-280111-6hiuzkvz cord-280233-avmisu31 cord-280060-gzby85u9 cord-280348-vrnxucye cord-280030-neqycg6v cord-280360-rh37d5wc cord-280821-kc0ut4oy cord-280848-z0sbztkw cord-280241-h16s6wwm cord-280984-2j8ckz14 cord-280996-anq680a1 cord-280961-fka8c69p cord-280944-uphs5gvl cord-280431-tuzdng4h cord-281060-1ud5hzlh cord-281003-7pdhxdzc cord-281130-9tawihti cord-280551-9hoxy5ok cord-280794-k591vqji cord-280554-9jp85yzz cord-281039-a7q5nzwn cord-280358-ru2hv6pz cord-281064-b69p44uq cord-281276-rffp6qe2 cord-281283-h6yai7sx cord-281175-og3myz22 cord-281106-vzb5xzza cord-281346-bjhdy8mg cord-281332-5mddyv0n cord-281561-r10y2sgb cord-281391-0qkku2jd cord-281752-64mrflcr cord-281887-b511bjdy cord-281945-jvnjzjds cord-281344-iswbgqqe cord-282183-k0pn0ie2 cord-281566-6v5zfue6 cord-281298-qheq9lc8 cord-282483-0zsvhoog cord-282219-7kzbnymp cord-282097-a1pwq4fi cord-281729-z321pebe cord-282043-cs1oyohu cord-281733-bsq0ewac cord-282660-9x937eus cord-282361-gje78nb1 cord-282589-xof56j98 cord-281804-lhnw8jx5 cord-282535-gnuhjs32 cord-282430-u5ukqc5z cord-282151-mai4eggf cord-282021-m1lh7mzd cord-282724-zzkqb0u2 cord-282704-qg2o0ug4 cord-282474-74273qgk cord-282730-pawasfh4 cord-282610-zim7nond cord-282504-m3npy0om cord-283141-dh8j7lyl cord-282963-p04c5nn7 cord-282783-ps5jyjkl cord-282780-34j7gquo cord-282956-f7if9e5q cord-282867-kbyxdegu cord-283165-mdkr9qo0 cord-283738-v3h7p297 cord-282912-jegpgqqi cord-283215-dgysimh5 cord-283513-3f4rsgzm cord-283517-7gd0f06m cord-284163-3jmqzemf cord-283583-pwlbrxn3 cord-283779-mudwcypl cord-283682-4fcyoyea cord-283267-72wrzw09 cord-284038-93s3ffoy cord-283826-lgyc3sro cord-284188-ujdla954 cord-283719-zmizyx7e cord-283806-a6exd6dn cord-284042-awl5bb0j cord-283231-ju71zm7w cord-284387-cjziykrz cord-284365-g46myqe7 cord-284298-tcied4l5 cord-283969-wqrzaxsu cord-284454-malfatni cord-284175-5rre1kbn cord-284545-vn60yd46 cord-284332-p4c1fneh cord-284526-a5kgo4ct cord-284983-xvtkso79 cord-284251-brn5izwo cord-285354-bp2dozzg cord-285472-cj5r3xt1 cord-285469-b61y9ezi cord-285360-svczr721 cord-284979-lyt98od1 cord-284995-8lyr3gs4 cord-284576-nemh4wdo cord-285897-ahysay2l cord-284804-6i5zbmm1 cord-285291-pep4opiq cord-284944-hcgfe9wv cord-285818-eh12luma cord-285467-uxfk6k3c cord-285755-zblitbo0 cord-285414-vd2d7db2 cord-284910-vjcrhwqz cord-285226-4ydvjmr3 cord-285867-61y4aamj cord-285757-fiqx4tll cord-285907-xoiju5ub cord-286227-foeb0g7u cord-285588-ug7upa3r cord-286418-9ho5fg3h cord-286403-gdkwabcj cord-285298-r7p44wpe cord-285732-xew5ar1e cord-286638-bqxyb61p cord-286096-h275nner cord-286525-0354438s cord-286477-0euaaspo cord-286237-x6dr6rsh cord-286574-t9z2ynt5 cord-286683-mettlmhz cord-286743-z0e5arlm cord-287102-o19uwryp cord-287048-5od0ssyk cord-285772-4xt4anq5 cord-287117-3v9nyagt cord-286293-f5qg7vcz cord-286611-e1i1wemo cord-286853-9gbel3pq cord-286843-8qh1pblc cord-287515-oe7adj91 cord-287468-e5h4tmy6 cord-287373-7xjn05k8 cord-287222-wojyisu0 cord-287210-sars5dmi cord-287508-133inel2 cord-287367-1sdt9zz8 cord-287161-hqrql1lh cord-287520-51kmd2ds cord-286607-5i406twr cord-287544-n32iscmr cord-287648-nhsn4cru cord-287558-yc8aw2pg cord-287376-wxldnlih cord-286334-d9v5xtx7 cord-287786-zfe0el8i cord-287538-qbf5lv7d cord-287742-y1j9x5ne cord-287505-ihqzpdar cord-287497-93oiiqqi cord-287901-56goaqir cord-287765-nsdequl9 cord-287957-diyz54qy cord-287874-wl0wlxh6 cord-288033-9xu1ujcq cord-287732-abzpfdcu cord-287895-63wy5ztb cord-288158-6gicgsj8 cord-287953-prn8cnvo cord-288040-uuqfvvmk cord-288102-iom6lu7o cord-288067-36amafub cord-288009-8i3gsq9p cord-287758-da11ypiy cord-288222-8fqfbys2 cord-288271-p074ffpt cord-287991-10jz1dz2 cord-288197-drto66xt cord-288580-onzzpkye cord-288558-rthnj6wd cord-288371-uyj4iske cord-288181-9thl46oe cord-288255-p8uzrsbd cord-288051-wp8v2mc5 cord-289006-7dv1zsp9 cord-288697-9dywuhkc cord-288509-l6yn2er7 cord-288790-5uzgenty cord-289179-3zfur0zh cord-289064-435bp4rt cord-288575-srpc68t8 cord-288810-ab7k70c4 cord-288606-h8pmqwmk cord-289046-frhpt8n9 cord-289311-0wgafqdz cord-288552-7lp07v5i cord-289542-u86ujtur cord-289457-06gwrpu0 cord-289719-64ugdvfe cord-289219-qjxdggz3 cord-289115-bntcn0m6 cord-289690-af6lsj1g cord-289088-7uoia564 cord-289008-c4cu3vrp cord-289054-fh95b5n4 cord-290006-63sa00ju cord-289581-aozg3o9o cord-289169-3u7qgxud cord-289816-rlwoy8ms cord-289322-5ciaonf0 cord-289859-b1k9uyp6 cord-289553-gygvhzcc cord-289574-engwi8h3 cord-289930-7xm6q68s cord-289114-ifnk41oq cord-289533-hip9qtu5 cord-289854-p8okfa4b cord-289806-6ihptx6n cord-289775-40bi87iz cord-290041-zxlq63n5 cord-289828-3k088z9n cord-290028-oyd7vzj6 cord-290081-pjg00t7g cord-289973-1mczuxsy cord-290551-a02tueuu cord-290200-csmisulw cord-289612-4x5t4c5u cord-290401-t87i3exo cord-290267-ke696q8j cord-290295-gl144dh9 cord-290065-ouua7wnq cord-290658-r2bqqovo cord-290341-ei768v4s cord-290051-22gwwrpw cord-290712-flj352ql cord-289852-4uxb70rh cord-290195-8uaai9nv cord-290750-85731og8 cord-290975-2kmvyovm cord-290326-umv0q4d7 cord-291016-c83fs5ih cord-291265-qmylxndp cord-290611-fhaguv3f cord-291052-nstfe15a cord-290832-zmj59rc3 cord-290856-6de0mwg0 cord-290947-5ewpvo4j cord-291024-9g4om4sf cord-291340-8gj0ofmp cord-290836-jldfrec9 cord-290771-18dj37dj cord-291168-4u4cssky cord-291397-look6ddt cord-291176-evb6yt0r cord-291025-u5z8zji3 cord-291244-o4isx15k cord-291388-tt9eq7e0 cord-291469-cohrewj5 cord-291413-cgec7150 cord-291624-fod0eyuj cord-291686-kgewmqg5 cord-291588-tp89j1kk cord-291417-p49ukyhx cord-291430-rsu6xviv cord-291670-mqj071gp cord-292056-dtdyxhq4 cord-292345-zc209dfx cord-291566-jwlvustd cord-292474-dmgd99d6 cord-291697-wpnq9wc0 cord-292054-x0saq938 cord-292315-7vwybku8 cord-291687-kwu0otpi cord-291855-wtwz94sy cord-292561-iy06b9h9 cord-292620-t8ocqm6g cord-291873-inzzywps cord-292394-91b3mm6c cord-292493-lx7zfgoi cord-292335-al6v3b9x cord-292485-vk5xy3zn cord-292350-cmrtg91a cord-292826-lus0tqmi cord-293167-3bd3adip cord-292387-2xv3wgaq cord-293285-w8c3ma8l cord-293333-mqoml9o5 cord-292094-vmsdhccp cord-293143-1k170shh cord-293575-h3wc7j4v cord-292952-z7ajsf2r cord-293570-gh6ykmea cord-293180-f1ulk9ce cord-293522-gg706q8s cord-294057-fbox3a5q cord-293086-6282sb6b cord-293730-dlqo6fep cord-293964-hz5uow2b cord-294487-hcuzxhb3 cord-292856-7hjzzxtm cord-293547-29i3u83s cord-294073-65h2mkdy cord-294336-fqobpo47 cord-294108-uvnh0s9r cord-293852-r72c6584 cord-293472-d3iwlpsr cord-294270-do6i6ymq cord-294184-jte9xx5e cord-293634-4rryqbnu cord-294349-ps3qlho2 cord-294443-w6p3f5qc cord-294617-i8j36bol cord-293922-knzv4jvj cord-293704-tnik6sd3 cord-294139-78c5h7la cord-295123-x2gxgave cord-294636-xes8g0x4 cord-294294-66udu5y4 cord-294527-fct2y5vn cord-294079-px9c20il cord-294628-ecg13s7a cord-294371-xot2oj2t cord-294907-i836d6im cord-294933-oc2glu4a cord-294064-vdpak3fm cord-293740-4c3yemi3 cord-294959-xy8976jz cord-294969-57xgqf2g cord-295514-vhymj0rw cord-294768-bs6thjw2 cord-295216-eff02z0i cord-294557-4h0sybiy cord-295332-wlnss6bg cord-295086-tc3re52f cord-294700-pb5k21da cord-295323-snrt9odv cord-294593-mh1uh1b3 cord-294810-mq9vjnro cord-295414-v10454ns cord-295371-ccqne6nu cord-295144-tyyc81uc cord-296018-lgx5k2kp cord-295800-w0dup04b cord-294788-9usyb1nn cord-296113-syi2fwuo cord-295971-jtv1jj2z cord-296182-hhswage4 cord-295798-x7or932x cord-295523-5pv7kw6i cord-295794-glcg36si cord-296588-q2716lda cord-295700-lzaxzuwe cord-296494-6kn4mr04 cord-296562-3h2oqb9k cord-296605-p67twx7a cord-296013-6ej3pd0u cord-296219-zzg9hds0 cord-295703-no45mgyd cord-296676-2anl2agl cord-296331-i4hyzqcv cord-296694-2js639bk cord-296440-18vpg419 cord-296607-h2zwlyz7 cord-297127-nhgm09db cord-296881-2g81sjnl cord-297208-f4ob3ox6 cord-297132-lhfa9fl5 cord-297138-t8b3914h cord-297093-ld89vmct cord-297327-19dfgfz6 cord-297532-ktiwfcop cord-297638-ab70s980 cord-297832-picpuzvo cord-297759-arg71du6 cord-296773-5o4hr6ir cord-296936-5gkx4jxa cord-297414-zq16s9ud cord-297836-y9vt6wvu cord-298067-awo3smgp cord-297494-6yxmaihl cord-297001-4g3wb8qi cord-298325-2gm4fnqi cord-298034-0ntxm28a cord-298516-0eda4mzs cord-297518-6y2uzcde cord-297506-1xjgsz4y cord-297840-z5l6vdsr cord-298679-w0yp4u19 cord-297425-vcqqssm8 cord-298403-ilpzj2sv cord-298094-ctikhqvr cord-298056-svwtfshi cord-298787-4vo9gpiu cord-299024-jkqdzt87 cord-298894-t5hyfum3 cord-298967-vjyh1xvh cord-298974-69xjc5yq cord-297870-m7n43k4p cord-299082-s8bm40vy cord-299681-smhto9em cord-299489-6v225vte cord-299222-vmofcrim cord-299570-1xz5r95f cord-299124-g70v4crs cord-299333-qu0bmov5 cord-299156-1dwsm3ie cord-299449-226dd23u cord-299835-92karhpl cord-300038-1fjb6b8e cord-299621-m4kdkmey cord-299881-weptfpa2 cord-299750-zkrlm3ds cord-300356-oorac5he cord-299254-kqpnwkg5 cord-300344-57vxlctl cord-300995-tqz2bkdo cord-300044-vn4c6wh7 cord-299679-6z9e5gi6 cord-300608-eju7wnb9 cord-299784-xxxdjfbc cord-300774-5mrkmctl cord-300559-vuuxthx2 cord-301011-xbuqd0j5 cord-300866-cso6l6ze cord-299346-f13xly6q cord-300183-z3fwtwqb cord-300510-fhpkdqr0 cord-300697-p96i25uc cord-300445-qzu4gz2d cord-300458-jeuwaj50 cord-300080-l0fyxtva cord-300303-d4qmtysd cord-301079-n1nytr6k cord-301281-yur5hs2h cord-301391-5dvf1mi0 cord-301342-ikvpkhfp cord-300811-l4y7df2f cord-301146-no9pw4gn cord-301087-9vl5pqi7 cord-301592-n5ns3m34 cord-300963-1n1f8mf2 cord-301832-6czrdmzb cord-301811-ykpiorgo cord-301805-sb0ij8k7 cord-301340-lhh04pum cord-301579-q23nhmgs cord-301590-70qmpccs cord-301521-mpm43aga cord-301148-duttw9xn cord-301402-andxwyi3 cord-301947-b6nwaost cord-302062-wqmynngg cord-302115-r39ser2c cord-301779-y07xjnpe cord-301992-oin1m0uq cord-302244-uwicyuhk cord-301800-ssdzd43t cord-302389-h7jm1etb cord-302316-raf5rlkq cord-302215-sqrbj5r4 cord-302459-grs2x26l cord-302448-2r4rtixg cord-302667-ei151qpd cord-302684-r4ger87o cord-302177-8w3ojgd4 cord-302403-kahi8cbc cord-302788-kg8zwysg cord-302413-7a80jff2 cord-302226-0rhgmtbo cord-302862-znnlyz3y cord-302695-vyo3w2a4 cord-302382-eifh95zm cord-302806-1e99cygs cord-302864-2xnq1oq7 cord-302576-fv2ib5vc cord-303145-rc5luali cord-303600-96vtj89w cord-302756-343y63e5 cord-302821-b9ikg0xy cord-302997-39o08tt1 cord-303192-il3s8lgp cord-303017-4zx94rm6 cord-303244-5tfrmsm7 cord-303065-dyg2baog cord-303460-abutfxtf cord-303054-s1clwunc cord-303363-uu9hb1c9 cord-302800-852w35od cord-303880-zv4nbz9p cord-303661-etb19d6y cord-303349-0kn7apl3 cord-304010-n4gxxl5i cord-303483-wendrxee cord-303718-7bpap31f cord-303517-8971aq02 cord-303816-c4z9ys3q cord-304090-l5rocsk5 cord-303787-dx1n8jap cord-303819-w1785lap cord-304573-3nhglbw4 cord-304602-jpxjiaru cord-303703-ekhwb5xb cord-303860-jpy373ph cord-304280-2a84u4tm cord-304601-e6qlx1r6 cord-303791-yw80ndg6 cord-304949-mf3utolt cord-304248-sxbyxnxn cord-304271-vyayyk50 cord-304593-cugypxp0 cord-304474-hfv43e9m cord-304255-7xs9cit7 cord-304457-8g36h1bz cord-304418-k9owyolj cord-304798-j2tyjo1j cord-305134-s7h6bpof cord-304321-y177sqee cord-305076-v56y5nyt cord-305520-7gxmdo56 cord-305397-4dx3q6o6 cord-305139-851v2qr3 cord-304791-wv4qu9xm cord-304399-7t2mu13s cord-305283-1bg1ykui cord-306092-5bi2q3jj cord-304972-aktfbriw cord-305205-ilxxkm0f cord-305498-8tmtvw1r cord-305838-i0ck2oo0 cord-305650-su6furzi cord-306062-g9hk1iq5 cord-306149-sd0s0jup cord-305304-d3x734nu cord-305422-t8azymo7 cord-306090-i8sriw08 cord-305479-o47mv4uw cord-304479-uxp1kg86 cord-305405-me4gebvm cord-305959-x061q8t7 cord-306266-8qdrshz3 cord-306108-ja0wyr5w cord-306595-ru725fbr cord-305534-936peb1n cord-306670-c2jm0g88 cord-305582-3hmsknon cord-306790-82nltfk3 cord-306016-2gudro8v cord-305786-06dpjik8 cord-306351-ka6asw3m cord-307100-w33e2078 cord-306154-nm0g79ih cord-306997-84pjfawk cord-306377-s9j21zsy cord-307160-1vz0gw1w cord-306646-6c7n0xir cord-307258-66lwpblq cord-306896-khn8epxd cord-307660-onz6vfre cord-307217-0agij3z3 cord-307653-nyr6mtj1 cord-307690-1qqyixun cord-307285-bxy0zsc7 cord-307758-a4sgt66g cord-308071-1bk3xuwf cord-308010-ix0xi5jb cord-308390-ei96iuw3 cord-308184-w8ewm8ve cord-308075-1ftswsm8 cord-307309-s0t4kp2x cord-307862-a082sghm cord-308252-qwoo7b1l cord-308169-a0ft6wdy cord-308112-w96ncfla cord-307710-dlpfbnb1 cord-307287-zpq6byml cord-308195-nlibv0u4 cord-308313-3speddao cord-308002-abgv87e4 cord-308466-f0iu6sje cord-307808-0t6sw0zp cord-308907-elz62jlg cord-308212-l8flyso7 cord-308491-fc46k594 cord-308445-3j2q83ll cord-309024-pu830bn9 cord-309207-n8u8ddv7 cord-309214-v2iqgjc4 cord-309001-erm705tg cord-308906-et7duogt cord-308979-qhlvd2mt cord-309370-g8d3w7it cord-309236-p4c2d5y3 cord-308803-i934doud cord-309421-725u6dau cord-309194-jtouafgd cord-308968-m4pzsfkd cord-309395-5yan9fcn cord-309026-l2rh9bie cord-309441-obojsf04 cord-309302-n6cd2fc3 cord-309561-m43v332d cord-309323-yflng8m3 cord-309507-oe4i6v5x cord-309482-frawgvk7 cord-309238-7lbt0f03 cord-309360-cpis1l4u cord-309751-7elnvjk3 cord-309706-kikx05dj cord-309829-3dlfcy31 cord-309728-7vfotgrr cord-310010-oxgb6xnv cord-309735-bwa1zo07 cord-309962-phwq8rsf cord-310069-ay4af6xr cord-310117-19qsszns cord-310166-gt6icwul cord-309517-yh4d414y cord-310240-otf9ruvj cord-310001-qng7h5cj cord-310597-zy6ckr53 cord-310891-yfouizjb cord-310661-hrvuhkq9 cord-310405-7fah22nu cord-310084-taaz6mhs cord-310690-50z2kdaj cord-310823-xksu8fn1 cord-310663-504p29hv cord-310974-hz37yf39 cord-310539-8zk3hkgj cord-310205-j57x9ke6 cord-310901-oooat8xj cord-310177-4jw1lkli cord-311341-7ox30d2u cord-311043-nidu7om2 cord-310902-cfci8lef cord-311275-ysr9nqun cord-310976-24b3c3a4 cord-311074-j3fw4dfc cord-310676-125o0o7x cord-310685-gi2ycrfk cord-310917-9sk8gdh8 cord-311373-ngs7baoc cord-311044-kjx0z1hc cord-311730-189vax2m cord-311176-dlwph5za cord-310779-4puiao40 cord-311673-z4hkw17g cord-311579-4jhoatkw cord-311682-npi03i7q cord-311752-stqrf50k cord-311970-o9xao5rl cord-311848-8n9ee57a cord-311942-oju4gosw cord-311000-abntwzuy cord-311418-7core0y3 cord-311847-2czqs84q cord-311215-x3b7ewo2 cord-312063-5c2w2ct1 cord-311816-j8c2lk7y cord-312065-nqy7m38f cord-312199-jy3izkou cord-312249-k7dp776s cord-311838-ymn96yj4 cord-311957-3rmm1hfb cord-312313-guphuppy cord-312012-6a7i72bk cord-312388-pc89ybxw cord-312057-4zfaqkxm cord-312192-hxhohtmj cord-312609-gv1khfmo cord-312212-h5j4f0xq cord-312033-iarl77n0 cord-312467-kbhljong cord-312572-i7r28wdc cord-312677-rwznqiib cord-313028-0nhgxoim cord-312748-9v2bmbod cord-312209-3yi1w44v cord-312614-63qzissw cord-312798-2cbgnv1h cord-312754-3yhxcfr2 cord-312846-ef7m4875 cord-312795-0e4esl2o cord-312486-rumqopg0 cord-312918-iof45k1r cord-313136-ab56mg6j cord-313082-n3bo9jw1 cord-312847-2cg3ylfl cord-312632-g4250q6l cord-313294-ffgo56gl cord-312684-3i2r2ahr cord-313349-ikjivfce cord-313118-dv5xq2k4 cord-313353-uwwih8v3 cord-313728-08kwkbmd cord-313227-6zwkfzab cord-313494-a4pms2ub cord-313239-0gl43af5 cord-313529-xm76ae08 cord-313468-lloh1b0y cord-313628-6610z7xk cord-313693-qmkrn7pr cord-313684-61hkogdh cord-313785-8tipkksu cord-313528-rp15vi1o cord-313976-q5j5kr1v cord-313894-stgx36h5 cord-313836-mcm0xmzw cord-314088-ktj17dvq cord-314218-6znw9zcz cord-313989-bc7q8swu cord-313860-mzs3ya0s cord-314070-8qz23nn4 cord-314152-wd153s1g cord-314171-431buxxr cord-314378-cs9ggqwk cord-314280-kf2bo06e cord-314649-1y3ocvz1 cord-315056-ohyb6oa0 cord-315311-azamwuzl cord-314537-8a1vqale cord-314694-g0pes5o3 cord-315116-u7btx7nt cord-315249-yclnl87n cord-315297-o8mwmjql cord-314826-usfvulc2 cord-315397-cm3mc7we cord-314349-rhm1ii3d cord-315188-a9pvugjt cord-315195-m2xqlct8 cord-315181-emf4i6ir cord-315569-e56c5g8h cord-315486-pjb5v1tc cord-314106-r3axl3w1 cord-315574-jq1p5t8w cord-314449-ukqux772 cord-315970-m5o962yw cord-315149-71bmj5il cord-315834-ashjw2xs cord-315696-43wmazxa cord-315424-i3nnennw cord-315490-xs5v3uc3 cord-315871-anguylf1 cord-316067-mlcczr8c cord-315157-2p45frlk cord-316003-xt59voyt cord-316170-ihh0pxov cord-315730-fzgxuak7 cord-316137-6zdxfv8v cord-316083-f1h2j6jx cord-316306-vfez5k02 cord-316029-z708c3ex cord-316432-xemz7zn9 cord-316728-vyfkmniu cord-316095-jzyb4jn5 cord-316135-kevyw19w cord-316370-t802kjpk cord-316666-qif1k62t cord-316118-ph582weg cord-316376-76beuk0c cord-316673-ffkh13xm cord-316117-o29773cz cord-316845-k9zvsfvj cord-316572-7ei96rrn cord-316987-3nhqx2qn cord-316647-jj8anf5g cord-316522-fbw9x3ik cord-316835-qf0c91vr cord-316873-2gwl9m94 cord-317075-zegearxa cord-316616-j82q99in cord-316938-64jxtg9y cord-316743-q6gbxghx cord-317265-n6x0r58i cord-313474-1gux1gsi cord-316764-ps89rxuy cord-317242-e7000i2u cord-317028-f3bpwm5j cord-317151-cxx5pcln cord-317535-zep5axfo cord-317604-j8b64a1a cord-317085-qc8bfb9g cord-317468-pnxni1x5 cord-317811-mxsujb5u cord-317566-6ch6na31 cord-317809-umb8j63t cord-317689-gp4x54pe cord-317918-pl625ela cord-317344-wznzmssz cord-317932-5sqj2klm cord-318167-b25g6zkp cord-318282-ocgfgx9r cord-318021-4qrf5m8s cord-318063-bainw3d6 cord-317952-4oa9hfb4 cord-317575-srg9cyqp cord-318094-losjbgn6 cord-318229-29cgwivt cord-317966-ut6tzc8s cord-318694-370ccaoc cord-318355-38x3f3ee cord-318333-rzhrgp5q cord-318262-w8oixzdg cord-318909-h5b7mncf cord-318954-pj5lsvsa cord-318326-q9fnbg8n cord-318873-zwot69s3 cord-318944-13zk6cco cord-318803-xpa49sxt cord-318311-aakpbbvl cord-318369-y3wtfqrn cord-318830-a3n4c5d1 cord-319333-jwbgytwd cord-319037-77l9wdyb cord-318312-v1c3qm7h cord-318520-hgjv7ot9 cord-319400-lghjiw5p cord-319742-ypkt01rn cord-319849-3shr5grg cord-319930-ymqnb54a cord-319218-mejvlkfg cord-319615-p2labgd8 cord-318808-1cfwj5uq cord-319567-4t5t8bcx cord-320445-pdvkyzci cord-320572-94fvtj4a cord-319013-oytqcifa cord-320612-vam0bli3 cord-320349-6hbuq0k7 cord-320599-hxn4bgec cord-320184-wacoz5t9 cord-320149-3q4q98a6 cord-320811-9sm7iz5x cord-320267-n21jryi2 cord-320477-zbp8a8dr cord-321346-epsp3bbm cord-320877-1i0hzfjk cord-321064-pe8466n1 cord-320788-ln8ddyuj cord-320632-369kax2m cord-319805-b6ypt5d0 cord-320892-dcfi5u04 cord-320663-xypg6evo cord-319706-2e9jrv0s cord-321543-qdmvn44h cord-319823-sp5wibeh cord-320634-x7a3k5xu cord-320864-k9zksbyt cord-321149-hffj7s4o cord-320695-gq7k331z cord-321748-9a54ekac cord-321030-isc3p46t cord-320831-owfnttqr cord-321461-1s3y9kc5 cord-321768-oevswvvd cord-321594-x5wv9p7n cord-315598-qwh72inx cord-321651-7e8dwcur cord-321311-v2i1caug cord-321237-ynhdii60 cord-321788-z2y1ywdq cord-321552-lsz1onrj cord-321983-566pbuic cord-320930-9yiu0080 cord-322009-0cwljo0c cord-321472-n4nnmlv1 cord-322063-96suqyfg cord-322054-whjisspt cord-321837-0r86qxz1 cord-322066-m8dphaml cord-321784-nubu5fuz cord-321801-w66v5kzh cord-322052-zsbisk3b cord-322439-86dojc70 cord-322322-woz6lwdu cord-322394-b18fv3r3 cord-322102-4fi0y96f cord-322259-khknne8s cord-322104-f1dukpso cord-322534-eikz07zz cord-321697-yua3apfi cord-322746-28igib4l cord-322497-hdy3va8e cord-322867-1yxxe5d3 cord-322552-95bj65qf cord-322868-o3r0y6bz cord-322590-twnlaq24 cord-322448-s04e6po9 cord-322957-clf8f90t cord-322990-q07yy5k8 cord-323024-blc3mnbj cord-322663-a58e6pp8 cord-323133-gdg50omp cord-322799-opf1qwgl cord-323225-ou7pppum cord-322893-av8hj005 cord-323092-j2u0ny2u cord-323180-3ih0i81s cord-323255-elwfiima cord-323293-4gmnkg09 cord-323647-q67fa0m3 cord-322861-q7uk6rdp cord-323463-osf6t7cw cord-323314-y3k9dntf cord-323446-w2ci1bfr cord-323470-lpeeugdf cord-323538-9dlr6kqh cord-323809-bocidwg4 cord-323273-q53wf6au cord-323713-bc00vths cord-323831-1qadv7r1 cord-323705-n2rec4i8 cord-323965-6mzzibj8 cord-323910-lms3xw4k cord-323582-7y8pt72r cord-323489-ro7kbnu3 cord-323906-ro078y52 cord-323787-9lq8rkih cord-323980-rcyjthze cord-323816-3m1iu9j2 cord-323761-9m177ozm cord-323913-v32c2vda cord-324175-5c4ijkpm cord-324041-lqokztor cord-324669-qca0uwxo cord-324007-hapzf0fl cord-324666-fvk72o0p cord-324159-jv3lknl8 cord-324232-nupi7f72 cord-324245-cfiekxr4 cord-324125-wau2xq0x cord-324060-vvexfg1c cord-324148-bllyruh8 cord-324314-os1btxx1 cord-324601-s3rgxtg6 cord-323940-ubazgvov cord-324859-0yuhb5dl cord-324880-s1oqkqef cord-324843-r43u7sld cord-324529-xbrdtxnz cord-324809-16zvqizl cord-324635-27q3nxte cord-325201-yoy7kdli cord-324619-y7gilopu cord-325619-qmszgw66 cord-325628-pa3dkz2f cord-324944-ixh3ykrc cord-325511-ot66dj3i cord-325234-skshcrh1 cord-324679-rds8o5z4 cord-324918-36om8n2d cord-324810-92fosk3c cord-325655-1fktmpbj cord-325307-agaau27o cord-325316-uffxyas1 cord-324798-qh0cxp10 cord-325793-5vrr7msw cord-325869-3mvjc805 cord-325783-pqonn0as cord-325421-1ysn0kyr cord-325649-zzhsrytw cord-325766-hbppklm5 cord-325970-ivtunxrd cord-325631-c7jwizpj cord-325863-3t73v4ng cord-325700-f102uk2m cord-326185-gjte739i cord-325933-1qvpofvp cord-326023-vwukiwe4 cord-326703-akn92p1r cord-326272-ya3r0h1t cord-325971-volbaipv cord-326747-zwp13awk cord-325963-d0hvukbu cord-326643-obfvi3ms cord-326017-qw4qynqv cord-326851-0jxdnm1l cord-326468-xcy7v1tf cord-326984-o27rp468 cord-326751-fn43p19j cord-326752-45ckkv01 cord-326354-fhafg41x cord-326807-dii4u9gj cord-327017-b2refzfw cord-326834-eeldyj2u cord-326883-j7pbe50g cord-327165-vlyfbiem cord-327148-dzozl70h cord-326991-m0lfk0a9 cord-326785-le2t1l8g cord-327125-86ocr70d cord-326994-y8p724s4 cord-327413-zdbnoy1q cord-327397-8rxjju0t cord-327370-zo0n8wf6 cord-327432-ogw27tob cord-327214-kcbxyhhh cord-327349-rxb6zfoc cord-327442-e02y93f6 cord-327545-y3vejwtr cord-327481-m9r0p84v cord-327611-g2ssh0fk cord-327577-c0d09cyk cord-327632-2hz94uuw cord-327415-nu1msnui cord-327720-m6cofbj6 cord-327989-6p39cx2e cord-327622-ezgufe24 cord-327820-4bm7b934 cord-327818-1abweqko cord-328068-qoz85x3r cord-327961-ysatxwph cord-327597-fgnrujsf cord-327609-no58ucyq cord-328214-2azb8789 cord-327690-di7hfghi cord-327836-6o66a4i5 cord-328484-4iptwc3n cord-327764-4nlg26p5 cord-327827-oliw4ee5 cord-328513-81yvcgul cord-328384-jzfr2t3p cord-327641-hqnem2zs cord-328040-5qd05e4r cord-328289-3h3kmjlz cord-328438-irjo0l4s cord-328829-yywxmioq cord-328786-gkd9xcxa cord-328147-61gtx2h2 cord-328607-lzai90zq cord-329351-g9qlo3xh cord-328039-xt17gvcp cord-328895-p75b7jii cord-328525-80xk3gln cord-328640-4g7revha cord-328113-eczjjc2v cord-329152-1ixylnny cord-328814-s3963anw cord-328220-toeq4xq0 cord-329564-tmi1u224 cord-329215-awxfetdj cord-329582-y4gyw8vz cord-329863-r2vqsg5r cord-329741-604gtqx9 cord-329453-ry1diso2 cord-330431-9txstz4n cord-328569-1lx3fkv3 cord-329727-h47q76y8 cord-329344-06uk5sjp cord-328294-gii1b7s7 cord-330061-q4xi260z cord-329877-vish6v8e cord-330050-05nnihst cord-328487-glwslgjy cord-328307-378cfb23 cord-330368-rk31cwl4 cord-330655-crfj5adf cord-330676-urr9oqfc cord-330492-kbob8z48 cord-330597-nftwj0d5 cord-330136-o8df8szx cord-330831-3b7vfv9b cord-329985-5rji08p7 cord-330701-k68b0wqe cord-329856-0m5mc320 cord-330869-k5ro0edf cord-330369-75cotmn2 cord-329989-176cvimy cord-331109-a8e7r80d cord-330666-puhijixa cord-330359-c0l5xq5m cord-330856-j1wqrc8v cord-330573-rr2r8245 cord-330963-w24q8sn7 cord-331273-1fixwxuo cord-331317-q01uos7a cord-331434-2x9m37cw cord-329766-9bwdb6o2 cord-331114-lumfg138 cord-329444-t8ixrdpq cord-331268-kzy33hdb cord-330870-l0ryikhv cord-331449-0sow1im8 cord-330877-nsx4b4rm cord-330918-hsy8h1vb cord-331487-jh34klbg cord-331481-zeaqi1uc cord-331270-12zx0o2p cord-331452-y5lhawqo cord-331519-ye4dtna5 cord-331165-2yn1n3eq cord-331533-0toegbv8 cord-331547-uqmjhhna cord-331915-7idktu7c cord-332013-bl5d4xkc cord-332145-rw16o02g cord-331604-jf6ybip5 cord-331500-l3hkn2li cord-332153-fczf3lzc cord-332036-op6s8tr4 cord-331762-b0yufidn cord-332709-0plblo4k cord-331827-amg309uz cord-332233-01rdlf8l cord-333470-0a0i6vjn cord-333340-ekok0mp5 cord-333588-3krh1xzx cord-332150-j76726no cord-332087-xwturwju cord-332278-2p64ab2z cord-332861-7b5pzmk6 cord-333451-p2plpeew cord-334524-8uqnlpvc cord-333113-0k6xlmem cord-334367-w96iqo6q cord-332055-lrpfzsog cord-333816-cznwzcn9 cord-333453-v3gap8kj cord-332180-dw4h69tp cord-334324-remrcm2q cord-334715-902pfxyz cord-334790-lav794w0 cord-332774-t5untewz cord-333183-xyuj1j57 cord-333696-3ci9re9a cord-333429-bq7kfpby cord-333375-d7cgvjsm cord-333024-1yrmun3z cord-332480-3uodkrkp cord-332778-rf47ptj6 cord-334408-w0yxz7zb cord-334092-50r3h7jv cord-333684-j1sg46w9 cord-332992-8rmqg4rf cord-333688-bykbyojs cord-333175-klnxnxwm cord-334075-ruqd2c1j cord-335168-3ofarutr cord-333698-e73d9lbu cord-335078-z7k59k8o cord-333808-deifddar cord-335597-anrzcsrt cord-333142-ek7hct52 cord-332788-8lq9qygn cord-334212-3gqzeakb cord-334881-x9nxxled cord-334235-ymsiihwd cord-333528-9mczqtje cord-334495-7y1la856 cord-335312-yp73z008 cord-335351-8hdok02n cord-335033-cwhm7v0s cord-335759-io18c6z0 cord-332650-05oz5zwz cord-334188-bggt1i2e cord-334002-irbpehts cord-333654-8rg99di5 cord-333876-fhxkpbq7 cord-335198-qp964238 cord-335576-b34nc3ay cord-335338-wzxjn5ip cord-336194-5v395xae cord-335140-njg0ln33 cord-335593-cjb0daps cord-336053-cjq7szcn cord-335916-fh28qrt7 cord-335465-sckfkciz cord-333749-45v6b4tc cord-335095-epsi5qq7 cord-336306-hvy9ukhh cord-335680-wsczl68g cord-334773-yw2qgv13 cord-336252-e92omqyr cord-336258-dxps48bo cord-335719-tnimrff9 cord-334835-j6u8t8j2 cord-335795-hdko0zdw cord-335265-kuc3v5m9 cord-335540-lahu5dno cord-335141-ag3j8obh cord-336268-azgswke8 cord-335382-fk4um9nw cord-335892-hwahcec5 cord-336368-sudi4mdx cord-335918-uc225mhn cord-335744-haj5a7tf cord-336201-fl606l3b cord-336336-f01khqqr cord-336000-v88bq4bx cord-336314-xf6zvvl8 cord-336395-v157jzvv cord-336390-ptnpgh3j cord-335977-f00758o2 cord-336423-rs4bma9b cord-336438-mlgxiyur cord-336790-29im4gxw cord-337088-xxyhmn1t cord-336554-n8n5ii5k cord-336450-2ndan331 cord-336621-0w3rroir cord-336462-7dltsav4 cord-337115-vtjsigod cord-337094-aa3ourc6 cord-336614-u6alc6rs cord-337487-1lbopaso cord-337297-fkw8780t cord-337120-irpm5g7g cord-337010-dgy7qbl5 cord-337262-88qpfu6b cord-337338-7uj2r0gy cord-336782-0zkb39v1 cord-337896-mct29erg cord-336882-x9e6r0h0 cord-337302-fpz2jfuj cord-336563-hwemigk7 cord-336488-opjjowcq cord-337906-qis8h3r3 cord-337520-qp0ga6q8 cord-337995-z4rcczki cord-336810-77wq9laa cord-338968-b1gg2ha7 cord-338146-am5gg1qd cord-336784-24qizp9k cord-337898-ncrbd8rp cord-338192-2v9dbc9h cord-336543-ydrmlujj cord-337622-rc9pejmo cord-338517-1mxcssjj cord-339015-qn8wbnlw cord-338666-gg9qcpmz cord-339021-mhdaov1f cord-337926-6ddvqowr cord-337994-pkklt77i cord-338135-zwo7e7gy cord-338362-6zwvkqag cord-337431-3rrvm787 cord-338900-8ojah695 cord-337665-roelk7i5 cord-337644-aobdzwpx cord-338668-z2z4gte2 cord-338729-v2suoj3c cord-338683-nzgnpi6f cord-338346-e3fk6gz2 cord-339406-81a7fkpj cord-338602-6n309bnp cord-339333-7tpnbr8q cord-338023-gb5jgqcg cord-338605-3i5pvcgu cord-338131-6y96eyoq cord-338600-wpfcxnyu cord-339455-b8nu34vv cord-339267-p3djwg7v cord-338182-cetv78ba cord-339467-ewqxf02j cord-338419-n8cmv8mf cord-337965-z39q8ebq cord-338965-ewuqsfsf cord-339517-93nuovsj cord-338741-gy3ovkrt cord-339436-0k73tlna cord-339568-th2xmhb6 cord-339474-tsdq1rgz cord-339737-7qdjea6f cord-339940-80757pwu cord-339009-wcoch07b cord-339589-dl2qpc0t cord-339811-dms0rlmr cord-339044-qy4jab37 cord-339471-1510mzmy cord-339355-zkkj8a83 cord-339266-glmshsh6 cord-340051-r9kn34wd cord-335802-1kiqfy68 cord-338756-jzz250o1 cord-339705-x8l3zgfd cord-340164-vzdyy656 cord-339686-oybnk1j8 cord-339913-ps4nvvaz cord-339656-u0cpklsv cord-339885-mpzgrogd cord-339504-8svo2w3u cord-339695-3ij5pjjy cord-340232-cadu5ah8 cord-340204-3gm58qza cord-340650-mwsa326c cord-340415-6fte7krp cord-339956-o5o2yz1u cord-339679-9hghy9pd cord-340000-1e66aqih cord-340576-dabcs3w5 cord-340799-1awmtj52 cord-340826-2530zdeq cord-340687-99ad1rwq cord-339614-28s205p8 cord-335975-m6lkrehi cord-340536-azlajqbe cord-341202-1pg7rq2d cord-342555-5r9aa7u5 cord-340070-de7sfccy cord-341627-21m8rdhy cord-340542-jz7ca041 cord-340880-2qop8tcp cord-342810-41dghl0c cord-340710-dmow5p7k cord-342246-tnjtd9n3 cord-340314-5oz3013n cord-341197-e8m4oxma cord-342303-ddulfe06 cord-340984-blkhfhe2 cord-342857-vj6sw2ne cord-343052-dc9s2rau cord-343201-98scxky8 cord-342139-t2tukk0z cord-342519-tjr6dvtt cord-340253-lpner9f8 cord-340383-psjga23p cord-340430-x4oitcyh cord-340660-ocvy1ge2 cord-340651-g3518bq2 cord-340786-12vzsl6p cord-340766-aic570x8 cord-341234-2zgfcrwc cord-340908-8q7i5ds3 cord-340811-w4x4falm cord-341415-g781zhu6 cord-341314-1mav631s cord-341118-h5t87vf8 cord-341531-w788qwya cord-342068-zhk3wmou cord-341933-dwki1hwu cord-341284-jmqdnart cord-341999-nosdj7b2 cord-340857-teq5txm9 cord-342808-yonbowkb cord-342569-ja96xfns cord-343308-5i31ysee cord-341076-ox2ckhqu cord-341359-c34gyuv6 cord-342841-b1rucgmg cord-341670-o1v63zg8 cord-342786-dl8vjwfn cord-341919-8gnthufw cord-341591-ib8lsvku cord-342809-wrxejwms cord-343490-94vkfrtw cord-342979-pvewvmmf cord-343393-8hdygwip cord-343023-e1uv7t6p cord-342930-f7cw2ca6 cord-343715-y594iewi cord-342451-yfy5jcw6 cord-343452-4m0ub9iv cord-343819-1uki4b3d cord-342603-k0f33p3l cord-343205-zjw4fbfd cord-343437-cz1w9od9 cord-343876-2inr4mcy cord-343773-9f7ew8uj cord-343797-kpmz5kwg cord-343973-n5ogyxz7 cord-343917-67qjqxqh cord-343877-jzkaee16 cord-344004-z7pn7u6u cord-343743-6k3soh1l cord-343443-ljehete1 cord-344185-jz6ui4w3 cord-344117-lr6roxej cord-344135-pyibu6rj cord-343897-f4imrltt cord-344104-592r71l1 cord-343970-anocx4y1 cord-343832-xg3swuzs cord-344270-874i31h8 cord-344271-5aynmdsk cord-343566-epvswt7f cord-344389-aj9q73f0 cord-344120-7t5ce2hb cord-344191-veug3dae cord-344017-qldawc8m cord-344302-p0v6sl9x cord-344668-9m1vnpmo cord-344508-a67vsux2 cord-344431-2wq7msqz cord-344486-iu5flbcl cord-345028-56hg62be cord-344765-agt60ksx cord-344131-e7phs0jd cord-344709-5hy1e4t1 cord-345381-9cckppk2 cord-345445-9t1vebey cord-344939-rgxqobfw cord-344693-znw3dru4 cord-344729-sjjedgws cord-345628-a4c46m2w cord-345517-ji4cet51 cord-345296-4z7yfj5s cord-344853-s2p2csrx cord-345632-iha2c5zo cord-344967-t88pedeb cord-345779-frspku51 cord-345611-xv62h83a cord-345860-d02x3151 cord-345680-10phij1x cord-345655-fb4vv4my cord-345371-pjbviagq cord-345092-1ztfcpsb cord-345762-khvcoqti cord-346061-pbghgitg cord-345044-2fez1gu0 cord-345727-bcxkycjh cord-346241-w076l97s cord-346062-q0trgj12 cord-346288-9to4sdfq cord-346607-1mewok8l cord-346276-1dcp05rd cord-346345-jc9bq0zu cord-346987-fbqqf00i cord-345546-v7t26oos cord-347091-wbjpa5st cord-346389-gbmnoo84 cord-346894-iy35298o cord-346459-tkt5ldyo cord-346594-tbsxgz43 cord-346664-ilebaqx3 cord-346015-bzeqs5oh cord-346496-crhv0gnt cord-347105-my9nioko cord-347268-vb6z0hzb cord-347255-fl9lur4h cord-347064-ljd121no cord-347058-kejcwlng cord-347696-rsjwp0b3 cord-346721-l6y3n21b cord-346616-kr500kgj cord-347293-fp8phk0p cord-346205-vqgcq3qt cord-347375-5ucemm87 cord-347280-jpwf55l6 cord-346558-u1e0kzmm cord-348051-o1hxoasp cord-347607-ydbyonbg cord-347351-emdj66vj cord-347289-3yi5tz04 cord-347121-5drl3xas cord-346539-kxnrf5g5 cord-347414-t88654wo cord-347905-w0fnc43a cord-347238-yacn6xqk cord-347277-8bmcd22v cord-348422-werg9ofa cord-347697-uz0i6wfp cord-348202-6we8e60b cord-348501-8cvtqj7w cord-347752-2ejnva4u cord-348458-dwj90mbq cord-348881-w0moe21t cord-348172-q3zcn5pf cord-348672-e34103b1 cord-348430-8xk4dt7t cord-348423-zq86ms8w cord-348975-plne3xlz cord-348855-lnltoj1n cord-348813-v1sdodz9 cord-348578-chfb4i15 cord-348130-t9tysvr8 cord-349031-tbof9yqi cord-348755-2g5gi1du cord-349144-cvmebr3f cord-348879-opzkodt7 cord-347263-ci6mv72z cord-348570-plds5kbn cord-348364-jb0lvhq5 cord-349210-8t4a5qqo cord-349329-f0pbd968 cord-349263-mmfrqyrc cord-349280-12hc3mhq cord-349396-a6zyioc1 cord-349500-603v8lfb cord-349533-51cex2sl cord-349565-g1emvmdu cord-349678-79zlgjqi cord-350052-9431xqu1 cord-349566-zx9kt144 cord-350065-frg7gvf5 cord-349838-p6vfzbla cord-350232-zml4o93t cord-350166-loxe11d6 cord-349958-126yb5se cord-349740-xed4aybr cord-349949-jp0hvcg6 cord-349561-4mkiwg9k cord-341063-3rqnu5bu cord-349076-x3rjasg0 cord-349439-3z0b77r5 cord-350325-vu8v9epr cord-350131-rsrlri8m cord-350408-rqlkwoya cord-348535-tvs1snq8 cord-350179-ltk5hfc4 cord-350529-yqtu059x cord-350401-suefuurq cord-350437-dq1il88y cord-350338-lcsa06gm cord-349360-dv4lxx52 cord-350594-0zxq4lxc cord-350679-69lv4wbz cord-349775-zwslhjju cord-351224-jeedo5mc cord-350990-tywbe4o2 cord-350589-h6hotlqk cord-350904-wyg8ikph cord-350737-nrtrhq1f cord-351195-2fdqu2l1 cord-351446-j4ambec5 cord-350200-1w5u3w8i cord-351223-nnuoadh6 cord-350923-532lnnll cord-351184-kcc3p3ow cord-350578-wyz5jyjh cord-350639-iguadmw1 cord-351046-yq7287k9 cord-350959-bsbz3a1l cord-351457-fzj3ciif cord-351129-lzzyn570 cord-349408-2ser9zjc cord-350718-jzliir37 cord-351340-7y19ystp cord-351155-5bvo66yb cord-351531-wo1ggmmn cord-351020-wde3ki0k cord-351528-23lbs8al cord-351625-1we9wi1g cord-352193-izzqdg3v cord-351825-fdog73g2 cord-351555-hsgsuor2 cord-351896-j6h02ab5 cord-351762-n95ar9ci cord-351776-otx5qwyu cord-351604-x4rsdwqz cord-351722-3mw1te94 cord-352065-960xqft4 cord-352234-utjne1ef cord-351823-ldbscq4s cord-351735-x1lng449 cord-352177-05sku8a8 cord-352401-tmt1pmw9 cord-352302-are8vvhh cord-351819-ovpz36e7 cord-352304-tt2q5mgs cord-352159-qx16i7s1 cord-351431-xcqz9d3t cord-352846-p7hhv297 cord-351597-bdazrbsz cord-352544-7b6btzrx cord-352227-827987jf cord-352215-dhkvh45t cord-352579-ndcbmgfj cord-352828-4ecik6xw cord-352399-2xfzpw9m cord-352823-1os3kwp1 cord-352914-jccxzit1 cord-352901-ia34l2ml cord-352577-h3652seb cord-352557-l7sahv5t cord-352969-rpt7xja6 cord-353013-7cx0gnum cord-353059-39msyuxb cord-353180-hbwrzm6s cord-352937-htmp0avc cord-352905-ge3u32hm cord-352889-fl61z3w3 cord-352678-8f2ygul2 cord-353256-7nfklun9 cord-354127-sb8tovy2 cord-353281-leb7c7b0 cord-353228-fxrf5wsp cord-353004-ocnp758o cord-353375-92pu0pp0 cord-353484-q7d0ysbo cord-353200-5csewb1k cord-353671-xjpzhsup cord-353648-rl9dts7l cord-353956-gjv5cg3k cord-354223-0ckpz0bx cord-353987-hj94a04i cord-353786-284qn075 cord-354372-vfvnjmv1 cord-354103-4dldgqzf cord-354160-sca9bgeq cord-353293-vjdwh19x cord-353698-gj8sx3zy cord-353697-ocxextfj cord-353401-y1mxnth7 cord-355003-1o2midnh cord-354204-23xkug85 cord-354373-lldfoptb cord-353594-z1vxamvp cord-353599-cw29edwr cord-354619-pftjhtpo cord-354194-hf5ndv5f cord-354658-v451z3jq cord-354597-xubsodnk cord-354411-4emzxu09 cord-354168-omen8vvq cord-354720-fu19u2b0 cord-353340-l0icku0i cord-354689-dsv63it1 cord-353824-0oyvia6d cord-354216-4khdcjed cord-355039-qi4fwqbc cord-354337-a70avg2x cord-355028-1x7w1749 cord-355294-gifsqph6 cord-355533-5kgdg2nb cord-355264-ygzh8von cord-355031-l0tj7kp2 cord-354824-7fdcu2f0 cord-355146-6rat5j64 cord-355431-efwuy8p9 cord-355528-y4a1g6km cord-354749-zkgb16ae cord-355504-zsyvgm9c cord-355524-qx396wq1 cord-355190-ytdw1d5v cord-355898-hlkwwaqe cord-355033-txxylmrw cord-355549-6xnjj5h5 cord-355191-jghvq3cy cord-355484-2igc5wzx cord-355177-62v1qhia cord-355885-pg6mpuk5 cord-355384-qa7grviy cord-355558-r6r1t47c cord-355296-46jf56nc cord-356040-qdpkidn8 cord-356195-5pcaxpp9 cord-356371-w9ejgzvu cord-356215-0nypfw48 cord-356127-xy5tyd7t cord-356332-t0ahmh0h cord-356379-e8ohc25w cord-356056-82bvcuvd cord-356084-621qzpqd cord-356349-ey5vnddu cord-356246-4p0ok1mc cord-355589-3zdv9zim cord-356057-87kxlqdc cord-350571-6tapkjb6 cord-355038-o2hr5mox Creating transaction Updating pos table Building ./etc/reader.txt cord-005453-4057qib7 cord-009997-oecpqf1j cord-006870-f5w6fw6q cord-005497-w81ysjf9 cord-005727-li8pwigg cord-014538-6a2pviol number of items: 2,875 sum of words: 16,904,050 average size in words: 11,012 average readability score: 45 nouns: patients; study; disease; treatment; patient; results; infection; risk; cells; blood; cases; care; data; group; cell; time; therapy; years; analysis; days; age; use; studies; mortality; hospital; methods; levels; diagnosis; case; lung; symptoms; syndrome; pneumonia; cancer; rate; health; children; day; infections; response; system; management; factors; number; control; virus; coronavirus; groups; failure; surgery verbs: using; include; show; associated; increasing; perform; compared; following; reported; based; found; required; received; treated; reduced; develop; identified; providing; present; suggest; evaluated; related; considered; caused; improved; assess; occurred; observed; determined; needed; induce; leading; made; demonstrated; underwent; detected; decreased; remains; give; describes; confirmed; obtained; seen; resulting; taking; indicated; measured; according; known; involve adjectives: clinical; severe; acute; high; respiratory; significant; non; higher; positive; first; covid-19; different; low; pulmonary; medical; viral; common; specific; early; chronic; normal; patient; important; new; human; negative; lower; anti; primary; surgical; inflammatory; immune; available; renal; possible; many; mean; cardiac; median; several; potential; similar; multiple; present; small; single; large; effective; diagnostic; total adverbs: also; however; well; significantly; respectively; therefore; often; even; especially; critically; still; previously; usually; prior; currently; recently; particularly; highly; less; frequently; furthermore; clinically; commonly; potentially; statistically; now; approximately; moreover; mainly; later; first; alone; rapidly; least; generally; finally; relatively; directly; rather; already; additionally; yet; almost; together; initially; widely; far; immediately; retrospectively; early pronouns: we; it; our; their; they; its; i; them; he; she; his; her; us; you; your; itself; one; themselves; my; him; me; himself; ourselves; mg; ours; mrs; yourself; herself; oneself; myself; em; s; 's; il-1β; igg4; theirs; covid-19; aptt; rrt; iicas; iga1; https://doi.org/10.1101/2020.08; p210bcr; mine; ioaes; imagej; nvh1n1; itma; cha; + proper nouns: COVID-19; SARS; ICU; CoV-2; CT; mg; China; T; PCR; C; Hospital; Health; II; ARDS; •; University; MRI; Wuhan; Coronavirus; HSCT; CI; B; A; S.; Disease; IL-6; RNA; L; Fig; Table; Care; HIV; COPD; kg; IV; M.; ED; US; ACE2; CoV; Group; ±; Medical; C.; der; United; National; HLA; M; Society keywords: patient; covid-19; sars; icu; study; cell; infection; care; disease; result; treatment; group; cancer; hospital; pcr; china; method; case; ards; cov-2; clinical; day; conclusion; respiratory; il-6; copd; health; ace2; university; surgery; acute; severe; hiv; high; dna; pneumonia; lung; rna; increase; ppe; mri; ifn; ecmo; drug; cmv; blood; year; child; pulmonary; mers one topic; one dimension: patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC35282/ titles(s): Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia three topics; one dimension: patients; patients; patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400751/, https://www.sciencedirect.com/science/article/pii/S0122726220300859?v=s5, https://api.elsevier.com/content/article/pii/S0161475420301226 titles(s): ESP Abstracts 2012 | ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19 | Response of Practicing Chiropractors during the Early Phase of the COVID-19 Pandemic: A Descriptive Report five topics; three dimensions: patients covid disease; patients results blood; patients covid patient; patients study icu; patients study asthma file(s): https://www.ncbi.nlm.nih.gov/pubmed/32505227/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103189/, https://api.elsevier.com/content/article/pii/S0161475420301226, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588953/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148977/ titles(s): Immunology of COVID-19: current state of the science | 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel | Response of Practicing Chiropractors during the Early Phase of the COVID-19 Pandemic: A Descriptive Report | The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation | Aspects cliniques, physiopathologiques, et thérapeutiques de la sclérose en plaques Type: cord title: keyword-patient-cord date: 2021-05-25 time: 15:47 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:patient ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-295332-wlnss6bg author: AL Shareef, Khaled title: Cytokine Blood Filtration Responses in COVID-19 date: 2020-05-28 words: 2679.0 sentences: 155.0 pages: flesch: 50.0 cache: ./cache/cord-295332-wlnss6bg.txt txt: ./txt/cord-295332-wlnss6bg.txt summary: This work reviews effective methods of using filtration devices in treatment to reduce the level of various inflammatory mediators and discharge patients from the ICU faster. Another study involved 38 patients with septic shock associated with AKI who were treated with CVVHD with HCO membrane for 72 h. A crossover randomized double-blinded study was conducted to investigate the effect of the oXiris membrane on 16 septic shock patients with AKI. This membrane with continuous hemodiafiltration (CHDF) was used to treat 34 septic shock patients in addition to the conventional treatment according to the Surviving Sepsis Campaign guidelines. Severe acute pancreatitis patients (the study group) were treated with a combination of CPFA and CVVH, while the control group received CVVH. The authors recommend using blood filtration devices in addition to current treatment to reduce the number of patients admitted to ICUs. Correction to: clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. abstract: The real issue with the COVID-19 pandemic is that a rapidly increasing number of patients with life-threatening complications are admitted in hospitals and are not well-administered. Although a limited number of patients use the intensive care unit (ICU), they consume medical resources, safety equipment, and enormous equipment with little possibility of rapid recovery and ICU discharge. This work reviews effective methods of using filtration devices in treatment to reduce the level of various inflammatory mediators and discharge patients from the ICU faster. Extracorporeal technologies have been reviewed as a medical approach to absorb cytokines. Although these devices do not kill or remove the virus, they are a promising solution for treating patients and their faster removal from the ICU, thus relieving the bottleneck. url: https://www.ncbi.nlm.nih.gov/pubmed/32464624/ doi: 10.1159/000508278 id: cord-279435-ffgd2ets author: ALBalawi, Hani B title: COVID-19: Precautionary Guidelines for Ophthalmologists date: 2020-06-25 words: 3183.0 sentences: 148.0 pages: flesch: 49.0 cache: ./cache/cord-279435-ffgd2ets.txt txt: ./txt/cord-279435-ffgd2ets.txt summary: Healthcare providers, particularly ophthalmologists, are at high risk of a COVID-19 infection through unprotected contact with eye secretions during routine ophthalmic examinations that involve the use of direct ophthalmoscopy and slit-lamp examinations, which are usually performed in a setting that allows for close doctor-patient contact. In fact, ophthalmologists are at high risk of contracting the COVID-19 virus through unprotected eye contact with secretions during routine ophthalmic examinations with direct ophthalmoscopy and slit-lamp examinations, which are usually performed in a setting that has close doctor-patient contact. A three-stage control measure to reduce the transmission of the virus in the ophthalmology department in Hong Kong was based on text messaging to reschedule refill visits [6] ; a triage to identify patients with fever, conjunctivitis, and respiratory symptoms; asking those who recently traveled to areas infected with the virus to postpone their ophthalmology visits for 14 days; and the avoidance of micro-aerosol generating procedures, nasal endoscopy, and operations under general anesthesia. abstract: Several coronaviruses can infect humans, and the globally endemic human coronaviruses, HCoV-229E (human coronavirus 229E), HCoV-NL63 (human coronavirus NL63), and others, tend to cause mild respiratory diseases. The zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus type1 (SARS-CoV-1) have high fatality rates. In December 2019, the World Health Organization (WHO) was notified by Chinese authorities about an outbreak of pneumonia before the causative organism was identified in January 2020 as a novel coronavirus family. The WHO refers to the virus as coronavirus disease 2019 (COVID-19). Within several weeks, the outbreak has become an emergency, and many countries have since been affected. The method of transmission is not yet fully known but is thought to be mainly respiratory. Healthcare providers, particularly ophthalmologists, are at high risk of a COVID-19 infection through unprotected contact with eye secretions during routine ophthalmic examinations that involve the use of direct ophthalmoscopy and slit-lamp examinations, which are usually performed in a setting that allows for close doctor-patient contact. In light of these, specific measures are needed from an ophthalmic point of view to control the COVID-19 outbreak and to protect health care providers. url: https://doi.org/10.7759/cureus.8815 doi: 10.7759/cureus.8815 id: cord-295703-no45mgyd author: ALTAY, O. title: Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date: 2020-10-05 words: 3977.0 sentences: 231.0 pages: flesch: 50.0 cache: ./cache/cord-295703-no45mgyd.txt txt: ./txt/cord-295703-no45mgyd.txt summary: Combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate is being studied for the treatment of patients with COVID-19. CONCLUSIONS In patients with mild-to-moderate COVID-19, CMCS resulted in a significant reduction in recovery time and liver enzymes associated with hepatic function compared to placebo. Recently, we performed integrative analysis of multi-omics data on different metabolic conditions and found that combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and Lcarnitine tartrate may be used for treatment of the patients with non-alcoholic fatty liver diseases (11, 12) . In this randomized, open-label, placebo-controlled, phase 2 trial involving ambulatory COVID-19 patients, we found that the combination of CMCS and hydroxychloroquine significantly reduced the average recovery time compared with hydroxychloroquine and placebo (6.6 days vs 9.3 days, respectively). abstract: BACKGROUND The characteristics of COVID-19 outbreak and high fatality rate of COVID-19 infection have attracted the attention of scientists due to the strong interactions between components of metabolic syndrome, metabolic abnormalities, and viral pathobiology of COVID-19. Combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate is being studied for the treatment of patients with COVID-19. METHODS We conducted a placebo-controlled, phase-2 clinical trial involving ambulatory COVID-19 patients. A total of 100 patients were randomly assigned on a 3:1 basis to hydroxychloroquine plus CMCS or hydroxychloroquine plus placebo. The total treatment period for the hydroxychloroquine was 5 days, and for the CMCS/placebo was 14 days. Clinical status was evaluated daily by phone, using a binomial scale for subject reported presence or absence for multiple COVID-19 related symptoms. Plasma samples for clinical chemistry analyses were collected on day 0 and day 14. RESULTS A total of 93 patients completed the trial. The combination of CMCS and hydroxychloroquine significantly reduced the average complete recovery time compared with hydroxychloroquine and placebo (6.6 days vs 9.3 days, respectively). Moreover, there was a significant reduction in ALT, AST and LDH levels on day 14 compared to day 0 in the hydroxychloroquine plus CMCS group. The adverse effects were uncommon and self-limiting. CONCLUSIONS In patients with mild-to-moderate COVID-19, CMCS resulted in a significant reduction in recovery time and liver enzymes associated with hepatic function compared to placebo. We observed that CMSC is associated with a low incidence of adverse events. url: http://medrxiv.org/cgi/content/short/2020.10.02.20202614v1?rss=1 doi: 10.1101/2020.10.02.20202614 id: cord-290856-6de0mwg0 author: Abbo, Aharon (Ronnie) title: Technological Developments and Strategic Management for Overcoming the COVID-19 Challenge within the Hospital Setting in Israel date: 2020-07-31 words: 4152.0 sentences: 188.0 pages: flesch: 40.0 cache: ./cache/cord-290856-6de0mwg0.txt txt: ./txt/cord-290856-6de0mwg0.txt summary: A second key component of this challenge was the overwhelming surge in patient burden and the relative lack of trained staff and medical equipment which required rapid re-organization of large systems and augmenting health care efficiencies to unprecedented levels. This review article describes the early research and development response in Israel under the scope of in-hospital patient care, such as non-contact sensing of patients'' vital signs, and how it could potentially be weaved into a practical big picture at the hospital or national level using a strategic management system. This review article describes the early research and development response in Israel under the scope of in-hospital patient care, and how it could potentially be weaved into a practical strategic big picture that could help confront the next wave or any upcoming health crisis. The C 4 I™ system is a command and control tactical system integrating computing, communication, and intelligence information (for health care applications this applies for patient sensors), developed for military use by Elbit Systems. abstract: The coronavirus disease 2019 (COVID-19) pandemic has remarkably challenged health care organizations and societies. A key strategy for confronting the disease implications on individuals and communities was based on harnessing multidisciplinary efforts to develop technologies for mitigating the disease spread and its deleterious clinical implications. One of the main challenging characteristics of COVID-19 is the provision of medical care to patients with a highly infective disease mandating the use of isolation measures. Such care is complicated by the need for complex critical care, dynamic treatment guidelines, and a vague knowledge regarding the disease’s pathophysiology. A second key component of this challenge was the overwhelming surge in patient burden and the relative lack of trained staff and medical equipment which required rapid re-organization of large systems and augmenting health care efficiencies to unprecedented levels. In contrast to the risk management strategies employed to mitigate other serious threats and the billions of dollars that are invested in reducing these risks annually by governments around the world, no such preparation has been shown to be of effect during the current COVID-19 pandemic. Unmet needs were identified within the newly opened COVID-19 departments together with the urgent need for reliable information for effective decision-making at the state level. This review article describes the early research and development response in Israel under the scope of in-hospital patient care, such as non-contact sensing of patients’ vital signs, and how it could potentially be weaved into a practical big picture at the hospital or national level using a strategic management system. At this stage, some of the described technologies are still in developmental or clinical evidence generation phases with respect to COVID-19 settings. While waiting for future publications describing the results of the ongoing evidence generation efforts, one should be aware of this trend as these emerging tools have the potential to further benefit patients as well as caregivers and health care systems beyond the scope of the current pandemic as well as confronting future surges in the number of cases. url: https://doi.org/10.5041/rmmj.10417 doi: 10.5041/rmmj.10417 id: cord-279736-udsbcqfs author: Abdalkader, Mohamad title: Roadmap for Resuming Elective Neuroendovascular Procedures Following the First COVID-19 Surge date: 2020-07-27 words: 1887.0 sentences: 74.0 pages: flesch: 31.0 cache: ./cache/cord-279736-udsbcqfs.txt txt: ./txt/cord-279736-udsbcqfs.txt summary: As we emerge from the peak of the COVID-19 pandemic''s initial surge, we prepare for re-entry of elective neurointerventional procedures to optimize the care of patients and mitigate infectious risk, while concurrently preserving ongoing capacity to care for patients with COVID-19. Anticipated potential limitations in health care resources (personal protective equipment (PPE), ventilators, personnel, hospital space) resulted in triaged delays of non-emergent endovascular procedures and surgeries [1] [2] [3] . We discuss several aspects of care that should be considered during the neuroendovascular resumption of an elective phase including hospital bed capacity, PPE resources, pre-procedure testing and post-procedure care. While the re-introduction of neurointerventional elective procedures can expose an additional specific and related risk of infection and stress, advance preparation and the development of modified pre-procedure protocols, intra-procedural protocols (sharing similarities with acute neurological emergencies) [7] [8] [9] , and post-procedural protocols can help organize the care of the patient, optimize peri-procedural risk to both patient and health care provider, and accommodate for appropriate resource allocation. abstract: The COVID-19 pandemic led to prioritizing high-acuity care of COVID-19 patients, while deferring non-emergent neurointerventional procedures worldwide in order to both limit contagion and add capacity for the anticipated COVID-19 surge. More specifically, health care resources, health care workers, and personal protective equipment (PPE) were all reorganized to ensure availability for the anticipated care of COVID-19 patients. As we emerge from the peak of the COVID-19 pandemic's initial surge, we prepare for re-entry of elective neurointerventional procedures to optimize the care of patients and mitigate infectious risk, while concurrently preserving ongoing capacity to care for patients with COVID-19. We present a suggested roadmap which may have utility for those reopening elective neurointerventional procedures following the pandemic surge. url: https://api.elsevier.com/content/article/pii/S1052305720305954 doi: 10.1016/j.jstrokecerebrovasdis.2020.105177 id: cord-309751-7elnvjk3 author: Abdelnasser, Mohammad Kamal title: COVID-19. An update for orthopedic surgeons date: 2020-07-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has affected our world in a short period of time, and the orthopedic surgery practice was not an exclusion. Elective care was deferred in most health care facilities and emergency care was continued with strict precautions. With rapid progression of the pandemic, the response of the medical community is also rapidly changing in all aspects of delivering care. This led to a large number of publications with reports, guidelines, measures, ways to react to the crisis, and post-pandemic predictions and speculations. In this review we aimed at summarizing all the relevant information to the orthopedic surgery community. To do this, a comprehensive search was performed with all related terms on two scientific search engines, PubMed and SCOPUS, and the results were filtered by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. The result was 72 articles that were further reduced to 33 articles after full text reading. The resultant information was organized under 5 main headings; the impact of pandemic on the orthopedic practice, COVID-19 and the trauma patient, elective and emergency surgeries during the pandemic, peri-operative management of the patient with COVID-19, Miscellaneous effects of the pandemic such as those on training programs and the evolution of telemedicine. This review represents the most up to date information published in the literature that is a must-know to every orthopedic surgeon. url: https://doi.org/10.1051/sicotj/2020022 doi: 10.1051/sicotj/2020022 id: cord-337302-fpz2jfuj author: Abdihamid, Omar title: The Landscape of COVID-19 in Cancer Patients: Prevalence, Impacts, and Recommendations date: 2020-09-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Cancer patients are susceptible groups to COVID-19, and risk-adjusted models show that most cancer patients have a 25–39% mortality risk if infected with COVID-19. The infection rate of SARS-CoV-2 in cancer patients in China was 0.79% (12 of 1524 patients; 95% CI, 0.31.2%). The case fatality rate of COVID-19 in the overall population ranges from 2.3 to 8.0%; among these, the case fatality rate for cancer patients is at 5.6%. In a retrospective cohort study of 28 COVID-19-infected cancer patients, a total of 15 (53.6%) patients had severe outcomes with a mortality rate of 28.6%. In a pooled analysis by Aakash et al, a 2% cancer prevalence was found among admitted patients with COVID-19. In Italy, a report shows that among the 3200 patients who died of SARS-CoV-2, 19.4% were patients with cancer. In New York, 61 (28%) cancer patients succumbed to COVID-19 with a case fatality rate of 37% (20/54) and 25% (41/164) for hematologic and solid malignancies, respectively. Impacts of COVID-19 in cancer care include interruptions of life-saving therapies, distraction effects, and diagnostic overshadowing that involve diverting attention to the pandemic rather than to cancer patients and disruptions of primary palliative care to patients due to forced quarantine. Herein, we review the landscape of COVID-19 in cancer care. We also briefly share our experience and the measures in place to protect cancer patients against COVID-19 in our center. url: https://doi.org/10.2147/cmar.s272008 doi: 10.2147/cmar.s272008 id: cord-331273-1fixwxuo author: Abejón González, David title: How to restart the interventional activity in the COVID‐19 era. The experience of a private Pain Unit in Spain date: 2020-09-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The situation generated in the health system by the COVID‐19 pandemic has provoked a crisis involving the necessity to cancel non‐urgent and oncologic activity in the operating room and in day‐to‐day practice. As the situation continues, the need to reinstate attention for chronic pain patients grows. The restoration of this activity has to begin with on‐site appointments and possible surgical procedures. On‐site clinical activity has to guarantee the safety of patients and health workers. The objective of this review is to evaluate how to manage activity in pain units, considering the scenario generated by the pandemic and the implications of chronic pain on the immune system and proposed pharmacological and interventional therapies. Besides the established general recommendations (physical distance, surgical masks, gloves, etc.), we established specific recommendations that will allow patient treatment and relieve the disruption of the immune response. It is important to highlight the use of opioids with the least influence in the immune system. Further, individualised corticoid use, risk assessment, reduced immune suppression, and dose adjustment should take patient needs into account. In this scenario, we highlight the use of radiofrequency and neuromodulation therapies, techniques that do not interfere with the immune response. We describe procedures to implement these recommendations for individual clinical situations, the therapeutic possibilities and safety guidelines for each centre, and government recommendations during the COVID‐19 pandemic. url: https://doi.org/10.1111/papr.12951 doi: 10.1111/papr.12951 id: cord-340687-99ad1rwq author: Abourida, Yassamine title: Management of Severe COVID-19 in Pregnancy date: 2020-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The scarcity of data concerning pregnant patients gravely infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) makes their management difficult, as most of the reported cases in the literature present mild pneumonia symptoms. The core problem is laying out evidence on coronavirus's implications on pregnancy and delivery, as well as vertical transmission and neonatal mortality. A healthy 30-year-old pregnant woman, gravida 6, para 4, at 31 weeks of gestation, presented severe pneumonia symptoms promptly complicated with premature rupture of membranes (PROM). A nasopharyngeal swab returned positive for SARS-CoV-2 using reverse transcription polymerase chain reactions (RT-PCR). The parturient underwent a cesarean delivery. This paper is an attempt to outline management of the critical condition of COVID-19 during pregnancy. url: https://doi.org/10.1155/2020/8852816 doi: 10.1155/2020/8852816 id: cord-013370-gktnz644 author: Abreu, Maria T title: Providing Guidance During a Global Viral Pandemic for the Care of Patients With Inflammatory Bowel Disease date: 2020-10-21 words: 1840.0 sentences: 83.0 pages: flesch: 56.0 cache: ./cache/cord-013370-gktnz644.txt txt: ./txt/cord-013370-gktnz644.txt summary: We have partnered closely with the European Crohn''s and Colitis Organisation because of our shared desire to provide the best guidance to patients with inflammatory bowel disease at a global level, as well as to the physicians that are caring for these patients. The process is called a RAND panel wherein the members of IOIBD, as well as other very knowledgeable practitioners of IBD, voted on a series of statements largely having to do with the risk of infection with the SARS-CoV-2 virus and the development of COVID-19 in patients who have IBD. We urge you to continue to check the IOIBD or the ECCO websites for the most up-to-date information, and we hope to keep updating the guidance in all of the various dimensions of IBD care. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577405/ doi: 10.1093/ecco-jcc/jjaa116 id: cord-296331-i4hyzqcv author: Adapa, Sreedhar title: COVID-19 Pandemic Causing Acute Kidney Injury and Impact on Patients With Chronic Kidney Disease and Renal Transplantation date: 2020-06-04 words: 5086.0 sentences: 289.0 pages: flesch: 49.0 cache: ./cache/cord-296331-i4hyzqcv.txt txt: ./txt/cord-296331-i4hyzqcv.txt summary: COVID-19 infection causes acute kidney injury (AKI) and is an independent risk factor for mortality. The impact of COVID-19 infection on chronic kidney disease (CKD) and renal transplant patients is also discussed in the manuscript. Acute kidney injury (AKI) was seen in 5-15% of the cases infected with SARS-CoV and MERS-CoV, and had a higher mortality rate of 60-90% as per the literature [12] . We summarized the finding from multiple studies including patient characteristics, co-morbidities, incidence of AKI in general as well as ICU/severely ill patients, number of patients requiring continuous renal replacement therapy (CRRT), extracorporeal membrane oxygenation (ECMO) and mortality in Table 2 [9-11, 13, 19, 22-24, 26-32] . Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Infection. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan abstract: Coronavirus disease 2019 (COVID-19) caused by 2019 novel coronavirus (2019-nCoV) has caused significant mortality and has been declared as a global pandemic by the World Health Organization. The infection mainly presents as fever, cough, and breathing difficulty, and few patients develop very severe symptoms. The purpose of this review is to analyze the impact of the virus on the kidney. COVID-19 infection causes acute kidney injury (AKI) and is an independent risk factor for mortality. Angiotensin-converting enzyme 2 (ACE2) receptors, direct viral damage, and immune-mediated damage play important roles in the pathogenesis. AKI in COVID-19 infection could be from the synergistic effect of virus-induced direct cytotropic effect and cytokine-induced systemic inflammatory response. AKI caused in the viral infection has been analyzed from the available epidemiological studies. The proportion of patients developing AKI is significantly higher when they develop severe disease. Continuous renal replacement therapy (CRRT) is the most used blood purification technique when needed. The impact of COVID-19 infection on chronic kidney disease (CKD) and renal transplant patients is also discussed in the manuscript. No vaccine has been developed against the 2019-nCoV virus to date. The critical aspect of management is supportive care. Several investigative drugs have been studied, drugs approved for other indications have been used, and several clinical trials are underway across the globe. Recently remdesivir has received emergency use authorization by the Food and Drug Administration (FDA) in the USA for use in patients hospitalized with COVID-19. Prevention of the infection holds the key to management. The patients with underlying kidney problems and renal transplant patients are vulnerable to developing COVID-19 infection. url: https://www.ncbi.nlm.nih.gov/pubmed/32587651/ doi: 10.14740/jocmr4200 id: cord-298974-69xjc5yq author: Adegboye, Oyelola A. title: Network Analysis of MERS Coronavirus within Households, Communities, and Hospitals to Identify Most Centralized and Super-Spreading in the Arabian Peninsula, 2012 to 2016 date: 2018-05-07 words: 4305.0 sentences: 190.0 pages: flesch: 47.0 cache: ./cache/cord-298974-69xjc5yq.txt txt: ./txt/cord-298974-69xjc5yq.txt summary: The transmission connectivity networks of people infected with highly contagious Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia were assessed to identify super-spreading events among the infected patients between 2012 and 2016. e variables considered in this study were age, gender, patient type (whether the patient is a healthcare worker (HCW) or nonhealthcare worker), health outcome (dead or alive) as at the last day of follow-up, patient comorbidity status, types of exposure to known risk factors (animal contact and camel contact indirectly or directly or through consumption of camel products), and place of infection (classified as hospital, community, and household/ family). Patient 1664 was favoured (based on degree, closeness, betweenness, and eigenvector network centrality metrics) as the most important in the transmission network by having the highest number of secondary cases. In this study, several network centrality metrics (degree, betweenness, closeness, eigenvector, and 2-reach) were used to quantify the connectivity among MERS cases and to identify which patient requires prioritization for intervention. abstract: Contact history is crucial during an infectious disease outbreak and vital when seeking to understand and predict the spread of infectious diseases in human populations. The transmission connectivity networks of people infected with highly contagious Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia were assessed to identify super-spreading events among the infected patients between 2012 and 2016. Of the 1379 MERS cases recorded during the study period, 321 (23.3%) cases were linked to hospital infection, out of which 203 (14.7%) cases occurred among healthcare workers. There were 1113 isolated cases while the number of recorded contacts per MERS patient is between 1 (n=210) and 17 (n=1), with a mean of 0.27 (SD = 0.76). Five super-important nodes were identified based on their high number of connected contacts worthy of prioritization (at least degree of 5). The number of secondary cases in each SSE varies (range, 5–17). The eigenvector centrality was significantly (p < 0.05) associated with place of exposure, with hospitals having on average significantly higher eigenvector centrality than other places of exposure. Results suggested that being a healthcare worker has a higher eigenvector centrality score on average than being nonhealthcare workers. Pathogenic droplets are easily transmitted within a confined area of hospitals; therefore, control measures should be put in place to curtail the number of hospital visitors and movements of nonessential staff within the healthcare facility with MERS cases. url: https://www.ncbi.nlm.nih.gov/pubmed/29854034/ doi: 10.1155/2018/6725284 id: cord-293575-h3wc7j4v author: Adrish, Muhammad title: Association of smoking status with outcomes in hospitalised patients with COVID-19 date: 2020-10-05 words: 2658.0 sentences: 181.0 pages: flesch: 55.0 cache: ./cache/cord-293575-h3wc7j4v.txt txt: ./txt/cord-293575-h3wc7j4v.txt summary: Univariate Cox model for survival analysis by smoking status showed that among smokers only current smokers had higher risk of death compared with never smokers (HR 1.61, 95% CI 1.22 to 2.12, p<0.001). CONCLUSION: In our large single-centre retrospective database of patients hospitalised with COVID-19, smoking was associated with development of critical illness and higher likelihood of death. Our hospital is located in New York City where 13.1% of the Key Messages ► Does the smoking status affect outcomes of hospitalised patients with COVID-19. We included adult patients (aged 18 and above) with known smoking status who were hospitalised with COVID-19 for whom severity of illness could be established and had final disposition status at the time of the study. Use of tocilizumab was suggested in patients with evidence of disease progression (defined as worsening respiratory status or radiographic findings) and increasing inflammatory markers early in their acute COVID-19 illness. abstract: INTRODUCTION: Smoking causes inflammation of the lung epithelium by releasing cytokines and impairing mucociliary clearance. Some studies have linked smoking with severity of illness of COVID-19 whereas others have found no such association. METHODS: This was a retrospective analysis of all adults hospitalised with COVID-19 from 9 March to 18 May 2020. RESULTS: 1173 patients met the study criteria. 837 patients never smoked whereas 336 patients were either current smokers or past smoker and were grouped together in smokers group. Patients in smokers group were more likely to be male and had higher incidence of underlying chronic obstructive pulmonary disease (19% vs 6%, p<0.001), HIV infection (11% vs 5%, p<0.001), cancer (11% vs 6%, p=0.005), congestive heart failure (15% vs 8%, p<0.001), coronary artery disease (15% vs 9%, p=0.3), chronic kidney disease (11% vs 8%, p=0.037) and end-stage renal disease (10% vs 6%, p=0.009) compared with non-smokers. Outcome analysis showed that smokers were more likely to develop critical illness requiring mechanical ventilation (47% vs 37% p=0.005). Univariate Cox model for survival analysis by smoking status showed that among smokers only current smokers had higher risk of death compared with never smokers (HR 1.61, 95% CI 1.22 to 2.12, p<0.001). In the multivariate approach, Cox model for the survival, female sex, young age, low serum lactate dehydrogenase and systemic steroid use were associated with overall improved survival. CONCLUSION: In our large single-centre retrospective database of patients hospitalised with COVID-19, smoking was associated with development of critical illness and higher likelihood of death. url: https://doi.org/10.1136/bmjresp-2020-000716 doi: 10.1136/bmjresp-2020-000716 id: cord-293472-d3iwlpsr author: Afilalo, Marc title: Evaluation and Management of Seasonal Influenza in the Emergency Department date: 2012-04-06 words: 9919.0 sentences: 516.0 pages: flesch: 38.0 cache: ./cache/cord-293472-d3iwlpsr.txt txt: ./txt/cord-293472-d3iwlpsr.txt summary: During influenza season (testing should be done in the following persons if the result will influence clinical management) Outpatient immunocompetent persons of any age at high risk of developing influenza complications (eg, hospitalization or death) presenting with acute febrile respiratory symptoms 5 days or less after illness onset (when virus is usually being shed) Outpatient immunocompromised persons of any age presenting with febrile respiratory symptoms, irrespective of time since illness onset (because immunocompromised persons can shed influenza viruses for weeks to months) Hospitalized persons of any age (immunocompetent or immunocompromised) with fever and respiratory symptoms, including those with a diagnosis of community-acquired pneumonia, irrespective of time since illness onset Elderly persons and infants presenting with suspected sepsis or fever of unknown origin, irrespective of time since illness onset Children with fever and respiratory symptoms presenting for medical evaluation, irrespective of time since illness onset Persons of any age who develop fever and respiratory symptoms after hospital admission, irrespective of time since illness onset Immunocompetent persons with acute febrile respiratory symptoms who are not at high risk of developing complications secondary to influenza infection may be tested for purposes of obtaining local surveillance data abstract: Seasonal influenza causes significant morbidity and mortality, primarily due to increased complication rates among the elderly population and patients with chronic diseases. Timely diagnosis of influenza and early recognition of an influenza outbreak or epidemic are key components in preventing influenza-related complications, hospitalizations, and deaths. Emergency departments are the most frequent points of entry for most influenza cases and are well positioned to identify and manage influenza community outbreaks and epidemics. Emergency departments need specific infection control measures to curb the spread of influenza in the Emergency Department and hospital during the influenza season. url: https://api.elsevier.com/content/article/pii/S0733862711001209 doi: 10.1016/j.emc.2011.10.011 id: cord-253970-sbj869yy author: Agarwal, Amit title: Neurological emergencies associated with COVID-19: stroke and beyond date: 2020-08-11 words: 2417.0 sentences: 149.0 pages: flesch: 40.0 cache: ./cache/cord-253970-sbj869yy.txt txt: ./txt/cord-253970-sbj869yy.txt summary: There is limited knowledge on the neurologic manifestations of COVID-19 at present, with a wide array of neurological complications reported, ranging from ischemic stroke to acute demyelination and encephalitis. The second subset of neurological presentation involves a response to the cytokine storm and multi-system inflammation including acute demyelination, vasculitis, necrotizing encephalopathy, and posterior reversible encephalopathy syndrome. Table 1 provides a summary of the most common (1) vascular complications with stroke secondary to arterial or venous thrombosis, related to the known hypercoagulable state seen in COVID [4, 5, 14] , and (2) much broader gamut including diffuse leukoencephalopathy, acute demyelination, posterior reversible encephalopathy syndrome (PRES), necrotizing encephalopathy, and focal cytotoxic edema, primarily seen as a consequence of systemic inflammation and cytokine storm seen with COVID-19 [6] [7] [8] [9] [10] [11] [12] [13] . The most common neurological presentation reported has been ischemic stroke, secondary to arterial or venous thrombosis, because of the hypercoagulable state associated with COVID-19. abstract: Novel coronavirus disease (COVID-19) was declared a global pandemic on March 1, 2020. Neurological manifestations are now being reported worldwide, including emergent presentation with acute neurological changes as well as a comorbidity in hospitalized patients. There is limited knowledge on the neurologic manifestations of COVID-19 at present, with a wide array of neurological complications reported, ranging from ischemic stroke to acute demyelination and encephalitis. We report five cases of COVID-19 presenting to the ER with acute neurological symptoms, over the course of 1 month. This includes two cases of ischemic stroke, one with large-vessel occlusion and one with embolic infarcts. The remainders of the cases include acute tumefactive demyelination, isolated cytotoxic edema of the corpus callosum with subarachnoid hemorrhage, and posterior reversible encephalopathy syndrome (PRES). url: https://www.ncbi.nlm.nih.gov/pubmed/32778985/ doi: 10.1007/s10140-020-01837-7 id: cord-280996-anq680a1 author: Agarwal, Arnav title: High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission date: 2020-06-15 words: 7117.0 sentences: 383.0 pages: flesch: 42.0 cache: ./cache/cord-280996-anq680a1.txt txt: ./txt/cord-280996-anq680a1.txt summary: title: High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission Review 1: we synthesized results from randomized-controlled trials (RCTs) comparing HFNC to conventional oxygen therapy (COT) in critically ill patients with acute hypoxemic respiratory failure. Conclusions High-flow nasal cannula may reduce the need for invasive ventilation and escalation of therapy compared with COT in COVID-19 patients with acute hypoxemic respiratory failure. Conclusions High-flow nasal cannula may reduce the need for invasive ventilation and escalation of therapy compared with COT in COVID-19 patients with acute hypoxemic respiratory failure. We conducted two rapid systematic reviews commissioned by the WHO to summarize the evidence for the efficacy, safety, and risk of aerosol generation and infection transmission during HFNC use among patients with acute hypoxemic respiratory failure due to COVID-19. abstract: PURPOSE: We conducted two World Health Organization-commissioned reviews to inform use of high-flow nasal cannula (HFNC) in patients with coronavirus disease (COVID-19). We synthesized the evidence regarding efficacy and safety (review 1), as well as risks of droplet dispersion, aerosol generation, and associated transmission (review 2) of viral products. SOURCE: Literature searches were performed in Ovid MEDLINE, Embase, Web of Science, Chinese databases, and medRxiv. Review 1: we synthesized results from randomized-controlled trials (RCTs) comparing HFNC to conventional oxygen therapy (COT) in critically ill patients with acute hypoxemic respiratory failure. Review 2: we narratively summarized findings from studies evaluating droplet dispersion, aerosol generation, or infection transmission associated with HFNC. For both reviews, paired reviewers independently conducted screening, data extraction, and risk of bias assessment. We evaluated certainty of evidence using GRADE methodology. PRINCIPAL FINDINGS: No eligible studies included COVID-19 patients. Review 1: 12 RCTs (n = 1,989 patients) provided low-certainty evidence that HFNC may reduce invasive ventilation (relative risk [RR], 0.85; 95% confidence interval [CI], 0.74 to 0.99) and escalation of oxygen therapy (RR, 0.71; 95% CI, 0.51 to 0.98) in patients with respiratory failure. Results provided no support for differences in mortality (moderate certainty), or in-hospital or intensive care length of stay (moderate and low certainty, respectively). Review 2: four studies evaluating droplet dispersion and three evaluating aerosol generation and dispersion provided very low certainty evidence. Two simulation studies and a crossover study showed mixed findings regarding the effect of HFNC on droplet dispersion. Although two simulation studies reported no associated increase in aerosol dispersion, one reported that higher flow rates were associated with increased regions of aerosol density. CONCLUSIONS: High-flow nasal cannula may reduce the need for invasive ventilation and escalation of therapy compared with COT in COVID-19 patients with acute hypoxemic respiratory failure. This benefit must be balanced against the unknown risk of airborne transmission. url: https://doi.org/10.1007/s12630-020-01740-2 doi: 10.1007/s12630-020-01740-2 id: cord-275506-3t5gf66c author: Agbuduwe, Charles title: Hematolological Manifestations of COVID‐19: From Cytopenia to Coagulopathy date: 2020-07-14 words: 4280.0 sentences: 265.0 pages: flesch: 39.0 cache: ./cache/cord-275506-3t5gf66c.txt txt: ./txt/cord-275506-3t5gf66c.txt summary: [45] A retrospective study of COVID-19 patients admitted to ICU identified DVT in 25% with advanced age, lower lymphocyte counts and elevated D-dimers being significant risk factors. [63] Currently, the evidence base for the clinical management of COVID-19 is mostly limited to case series and other relatively small observational studies of hospitalised patients. Similar to findings in SARS patients, [64] lymphopenia is the most commonly reported hematological abnormality in COVID-19 and recent data shows that it can be predictive of disease severity. The use of convalescent plasma may, in addition, provide neutralising antibodies against SARS-CoV-2 and a small-scale clinical trial has reported modest but encouraging results in severely-ill but not in critical COVID-19 patients. In view of the increased thrombotic risk associated with COVID-19, prophylactic anticoagulation with low Accepted Article molecular weight heparin is recommended for all hospitalised patients with the disease and clinical trials are needed to investigate the role of more intensive anticoagulation and other experimental therapies. abstract: s Emerging data from the management of patients with Coronavirus Disease 2019 (COVID‐19) suggests multisystemic involvement, including the hemopoietic system. The hematological manifestations of COVID‐19 include blood count anomalies notably lymphopenia and neutrophilia which are of prognostic significance. Hyperferritinemia and elevated lactate dehydrogenase have also been associated with increased mortality. Furthermore, there is considerable evidence of a distinct coagulopathy associated with COVID‐19 characterised by elevated D‐dimers and an increased risk of thrombotic events. This comprehensive review summarises the latest evidence from published studies and discusses the implications of the various hematological manifestations of COVID‐19 with a view to guiding clinical management and risk stratification in this rapidly evolving pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32663356/ doi: 10.1111/ejh.13491 id: cord-300811-l4y7df2f author: Aggarwal, Gaurav title: Association of Cardiovascular Disease with Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis date: 2020-04-28 words: 2537.0 sentences: 147.0 pages: flesch: 46.0 cache: ./cache/cord-300811-l4y7df2f.txt txt: ./txt/cord-300811-l4y7df2f.txt summary: We conducted a meta-analysis of recent studies that reported the association of CVD with worse prognosis and increased mortality in COVID-19 patients. Inclusion criteria were observational case-control or cohort studies on COVID-19 patients with a history of CVD included, which reported outcomes of COVID-19 infection severity, clearly outlined the definition of "severe disease" and with sample size >10. To this end, we carried out a pooled analysis of current studies and evaluate the association between underlying or previous history of CVD conditions and outcomes of infection severity in COVID-19 patients. Pooled analysis of these studies did not find a significant association between previous history of CVD and mortality in severe COVID-19 disease (OR=1.72; 95% CI: 0.97-3.06, I 2 =0%, Cochran''s Q=1.56, p=0.46). A total of 3 (n= 566) studies reported data on mortality in all hospitalized patients COVID-19 disease and pre-existing history of CVD. abstract: Observational studies have reported an association between underlying cardiovascular diseases (CVD) and worse prognosis in COVID-19 patients, but this still remains unclear. We conducted a meta-analysis of recent studies that reported the association of CVD with worse prognosis and increased mortality in COVID-19 patients. Literature search through PubMed, the Cochrane Library, and Embase was completed by 2 reviewers from November 1, 2019 to April 20, 2020. Inclusion criteria were observational case-control or cohort studies on COVID-19 patients with a history of CVD included, which reported outcomes of COVID-19 infection severity, clearly outlined the definition of “severe disease” and with sample size >10. Data were abstracted independently by 2 authors. Studies were divided into two separate cohorts for analysis: severity (severe vs. non-severe) and mortality (non-survivors vs. survivors). Data was pooled into a meta-analysis to estimate pooled odds ratio (OR) with 95% confidence interval (95% CI) for each outcome. A total of 18 studies (n= 4,858 patients) were included. Sixteen studies were from China, while 2 were from the United States. Pre-existing CVD was associated with a significantly increased risk of a severe form of COVID-19 (OR= 3.14; 95% CI 2.32-4.24; I(2)=0%; Q= 8.68, p=0.73) and overall risk of COVID-19 all-cause mortality (OR= 11.08; 95% CI: 2.59-47.32; I(2)=55%; p=0.11). However, this study did not find a significant association between previous history of CVD and mortality in severe COVID-19 disease (OR=1.72; 95% CI: 0.97-3.06, I(2)=0%, p=0.46). Pre-existing CVD is associated with worse outcomes among patients with COVID-19. Clinicians and policymakers need to take account of these findings in implementing risk stratification models. url: https://www.sciencedirect.com/science/article/pii/S0146280620300943?v=s5 doi: 10.1016/j.cpcardiol.2020.100617 id: cord-277146-4a4vz36h author: Aggarwal, Mukul title: Hemostatic Abnormalities in COVID-19: An Update date: 2020-08-11 words: 4630.0 sentences: 271.0 pages: flesch: 40.0 cache: ./cache/cord-277146-4a4vz36h.txt txt: ./txt/cord-277146-4a4vz36h.txt summary: Multiple reports have reported the presence of deranged parameters of coagulation in patients of In this review, we will discuss the various pathophysiological mechanisms leading to COVID-19 associated coagulopathy (CAC), derangement in laboratory parameters, incidence, and risk factors of venous thromboembolism (VTE) and prevention and treatment of CAC. Pulmonary Intravascular Coagulation, its Histopathological Evidence and Contribution of Cytokine Storm COVID-19 patients have been shown to have high levels of D-dimer [8, 9] but unlike patients of sepsis, they only have a mild prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT), mild thrombocytopenia [4, 9] . They recommend standard dose LMWH as most preferred agent followed by UFH then DOAC for acutely ill and critical hospitalized patients with COVID-19. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy abstract: COVID-19 has emerged as a pandemic with lung being the primarily afflicted organ. Deranged hemostasis has been observed in patients with COVID-19 with scales tipped towards a prothrombotic state. The pathogenesis differs from disseminated intravascular coagulation with a primary pulmonary localization. This is referred to as pulmonary intravascular coagulopathy with strong component of thrombo-inflammation. This is reflected in the lab tests with an increase in D-dimer which correlates with severity and outcomes of disease. Common coagulation tests such as prothrombin time, activated partial thromboplastin time are only mildly prolonged while most patients have normal to increased fibrinogen and marginal thrombocytopenia. Overall, the patients have an increase in venous and arterial thrombotic events especially in ICU patients. Routine thromboprophylaxis with low molecular weight heparin is recommended in all hospitalized patients to reduce the incidence of thrombosis. Bleeding is uncommon and treated with blood products transfusion. This review shall discuss the hemostatic abnormalities in COVID-19 patients and their impact on prognosis. In addition, strategy of thromboprophylaxis and various academic society guidelines are discussed in detail. url: https://www.ncbi.nlm.nih.gov/pubmed/32837053/ doi: 10.1007/s12288-020-01328-2 id: cord-255460-r5p5helx author: Aggarwal, Sadhna title: Drug repurposing for breast cancer therapy: Old weapon for new battle date: 2019-09-21 words: 7318.0 sentences: 420.0 pages: flesch: 42.0 cache: ./cache/cord-255460-r5p5helx.txt txt: ./txt/cord-255460-r5p5helx.txt summary: A phase III clinical trial ''Breast Cancer Trial of Oral Everolimus-2 (BOLERO-2)'' that included everolimus in combination with exemestane was successfully completed in 2012 leading to the approval of everolimus by US FDA for the treatment of HR + , HER2 − advanced metastatic cancers that are resistant to letrozole or anastrazole [125, 126] . Docetaxel and paclitaxel are used as neoadjuvant or adjuvant therapy as single agent or in combination with other chemotherapeutic agents for the treatment of early, advanced and metastatic breast cancer in pre-and postmenopausal women. We thus conclude that comprehensive approach of selecting the most appropriate gene-protein-pathway-target-drug modeling via integration of system biology and bioinformatics holds the high potential of providing more efficient, safer and cost-effective chemotherapeutics for treatment of even the most stringent forms of breast cancer (metastatic and triple negative). abstract: Abstract Despite tremendous resources being invested in prevention and treatment, breast cancer remains a leading cause of cancer deaths in women globally. The available treatment modalities are very costly and produces severe side effects. Drug repurposing that relate to new uses for old drugs has emerged as a novel approach for drug development. Repositioning of old, clinically approved, off patent non-cancer drugs with known targets, into newer indication is like using old weapons for new battle. The advances in genomics, proteomics and information computational biology has facilitated the process of drug repurposing. Repositioning approach not only fastens the process of drug development but also offers more effective, cheaper, safer drugs with lesser/known side effects. During the last decade, drugs such as alkylating agents, anthracyclins, antimetabolite, CDK4/6 inhibitor, aromatase inhibitor, mTOR inhibitor and mitotic inhibitors has been repositioned for breast cancer treatment. The repositioned drugs have been successfully used for the treatment of most aggressive triple negative breast cancer. The literature review suggest that serendipity plays a major role in the drug development. This article describes the comprehensive overview of the current scenario of drug repurposing for the breast cancer treatment. The strategies as well as several examples of repurposed drugs are provided. The challenges associated with drug repurposing are discussed. url: https://doi.org/10.1016/j.semcancer.2019.09.012 doi: 10.1016/j.semcancer.2019.09.012 id: cord-323314-y3k9dntf author: Aggarwal, Sandeep title: Obesity and Metabolic Surgery Society of India (OSSI) Recommendations for Bariatric and Metabolic Surgery Practice During the COVID-19 Pandemic date: 2020-08-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Bariatric and metabolic surgery (BMS), the only effective option for patients with obesity with or without comorbidities, has been stopped temporarily due to the ongoing novel corona virus disease (COVID-19) pandemic. However, there has been a recent change in the governmental strategy of dealing with this virus from ‘Stay at Home’ to ‘Stay Alert’ in many countries including India. A host of health services including elective surgeries are being resumed. In view of the possibility of resumption of BMS in near future, Obesity and Metabolic Surgery Society of India (OSSI) constituted a committee of experienced surgeons to give recommendations about the requirements as well as precautions to be taken to restart BMS with emphasis on safe delivery and high-quality care. url: https://www.ncbi.nlm.nih.gov/pubmed/32829450/ doi: 10.1007/s11695-020-04940-3 id: cord-297132-lhfa9fl5 author: Aghagoli, Ghazal title: Neurological Involvement in COVID-19 and Potential Mechanisms: A Review date: 2020-07-13 words: 5940.0 sentences: 280.0 pages: flesch: 36.0 cache: ./cache/cord-297132-lhfa9fl5.txt txt: ./txt/cord-297132-lhfa9fl5.txt summary: In this review, we synthesize a range of clinical observations and initial case series describing potential neurologic manifestations of COVID-19 and place these observations in the context of coronavirus neuro-pathophysiology as it may relate to SARS-CoV-2 infection. The novel 2019 coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) results in a variety of symptoms including fever, cough, and fatigue [1] . The Kawasaki-like syndrome that is now described in young patients following COVID-19 infection and associated with a hyper-inflammatory state is further suggestive of a vascular inflammatory potential of SARS-CoV-2 [48, 49] . Once established in the CNS, SARS-CoV, the virus responsible for Severe Acute Respiratory Syndrome (SARS), has been shown to be capable of inducing rapid transneuronal spread and death of infected neurons in transgenic mice models expressing human ACE2 receptors [63] . abstract: As the current understanding of COVID-19 continues to evolve, a synthesis of the literature on the neurological impact of this novel virus may help inform clinical management and highlight potentially important avenues of investigation. Additionally, understanding the potential mechanisms of neurologic injury may guide efforts to better detect and ameliorate these complications. In this review, we synthesize a range of clinical observations and initial case series describing potential neurologic manifestations of COVID-19 and place these observations in the context of coronavirus neuro-pathophysiology as it may relate to SARS-CoV-2 infection. Reported nervous system manifestations range from anosmia and ageusia, to cerebral hemorrhage and infarction. While the volume of COVID-19-related case studies continues to grow, previous work examining related viruses suggests potential mechanisms through which the novel coronavirus may impact the CNS and result in neurological complications. Namely, animal studies examining the SARS-CoV have implicated the angiotensin-converting-enzyme-2 receptor as a mediator of coronavirus-related neuronal damage and have shown that SARS-CoV can infect cerebrovascular endothelium and brain parenchyma, the latter predominantly in the medial temporal lobe, resulting in apoptosis and necrosis. Human postmortem brain studies indicate that human coronavirus variants and SARS-CoV can infect neurons and glia, implying SARS-CoV-2 may have similar neurovirulence. Additionally, studies have demonstrated an increase in cytokine serum levels as a result of SARS-CoV infection, consistent with the notion that cytokine overproduction and toxicity may be a relevant potential mechanism of neurologic injury, paralleling a known pathway of pulmonary injury. We also discuss evidence that suggests that SARS-CoV-2 may be a vasculotropic and neurotropic virus. Early reports suggest COVID-19 may be associated with severe neurologic complications, and several plausible mechanisms exist to account for these observations. A heightened awareness of the potential for neurologic involvement and further investigation into the relevant pathophysiology will be necessary to understand and ultimately mitigate SARS-CoV-2-associated neurologic injury. url: https://www.ncbi.nlm.nih.gov/pubmed/32661794/ doi: 10.1007/s12028-020-01049-4 id: cord-214006-0w6bqrox author: Aghdam, Atae Rezaei title: Towards Empowering Diabetic Patients: A perspective on self-management in the context of a group-based education program date: 2020-10-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This paper provides a novel framework for maximizing the effectiveness of the Diabetes Group Education Program, which could be generalized in any similar problem context. url: https://arxiv.org/pdf/2010.13276v1.pdf doi: nan id: cord-269776-hj1s3ipp author: Agostoni, Angelo title: Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond date: 2004-09-11 words: 49824.0 sentences: 2688.0 pages: flesch: 44.0 cache: ./cache/cord-269776-hj1s3ipp.txt txt: ./txt/cord-269776-hj1s3ipp.txt summary: Concerning HAE-I and HAE-II, just as variations in serum concentrations of APP appear to determine which individuals in a normal population develop angioedema with a second perturbation of kinin metabolism, such as the use of ACE inhibitors, 96 it could be speculated that variations in either kinin activation or inactivation pathways might contribute to the differences in severity of angioedema in individuals with a pre-existing perturbation in kinin metabolism, such as a mutation in C1-INH (as occurs in HAE). 13, 14, 27 This increase in plasma bradykinin was demonstrated both for patients with HAE with C1-INH deficiency and for patients with drug-associated angioedema who had an angioedematous attack in conjunction with ACE inhibitor treatment. The patient''s daughter had recurrent skin angioedema and gastrointestinal pain attacks since age 12 years; therefore, with a normal C1-INH concentration and activity in both mother and daughter, a diagnosis of HAE type III was assumed. abstract: Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to intra-abdominal edema. Resulting from mutations affecting C1 esterase inhibitor (C1-INH), inhibitor of the first complement system component, attacks are not histamine-mediated and do not respond to antihistamines or corticosteroids. Low awareness and resemblance to other disorders often delay diagnosis; despite availability of C1-INH replacement in some countries, no approved, safe acute attack therapy exists in the United States. The biennial C1 Esterase Inhibitor Deficiency Workshops resulted from a European initiative for better knowledge and treatment of HAE and related diseases. This supplement contains work presented at the third workshop and expanded content toward a definitive picture of angioedema in the absence of allergy. Most notably, it includes cumulative genetic investigations; multinational laboratory diagnosis recommendations; current pathogenesis hypotheses; suggested prophylaxis and acute attack treatment, including home treatment; future treatment options; and analysis of patient subpopulations, including pediatric patients and patients whose angioedema worsened during pregnancy or hormone administration. Causes and management of acquired angioedema and a new type of angioedema with normal C1-INH are also discussed. Collaborative patient and physician efforts, crucial in rare diseases, are emphasized. This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder. url: https://www.sciencedirect.com/science/article/pii/S0091674904017579 doi: 10.1016/j.jaci.2004.06.047 id: cord-334495-7y1la856 author: Agricola, Eustachio title: Heart and Lung Multimodality Imaging in COVID-19 date: 2020-06-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract SARS-CoV-2 outbreak has rapidly reached a pandemic proportion and has become a major threaten to global health. Although the predominant clinical feature of COVID-19 is an acute respiratory syndrome of varying severity, ranging from mild symptomatic interstitial pneumonia to acute respiratory distress syndrome, the cardiovascular system can be involved with several facets. As many as 40% hospitalized patients presenting with COVID-19 have pre-existing history of cardiovascular disease and current estimates report a proportion of myocardial injury in COVID-19 patients ranging up to 12%. Multiple pathways have been advocated to explain this finding and the related clinical scenarios, encompassing local and systemic inflammatory response and oxygen supply-demand imbalance. From a clinical point of view, cardiac involvement during COVID-19 may present a wide spectrum of severity ranging from subclinical myocardial injury to well-defined clinical entities (myocarditis, myocardial infarction, pulmonary embolism and heart failure), whose incidence and prognostic implications are currently largely unknown due to a significant lack of imaging data. The use of integrated heart and lung multimodality imaging plays a central role in different clinical settings and is essential in diagnosis, risk stratification and management of COVID-19 patients. Aim of this review is to summarize imaging-oriented pathophysiological mechanisms of lung and cardiac involvement in COVID-19 and to provide a guide for an integrated imaging assessment in these patients. url: https://api.elsevier.com/content/article/pii/S1936878X20304770 doi: 10.1016/j.jcmg.2020.05.017 id: cord-323582-7y8pt72r author: Ahamad, Martuza title: A Machine Learning Model to Identify Early Stage Symptoms of SARS-Cov-2 Infected Patients date: 2020-06-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The recent outbreak of the respiratory ailment COVID-19 caused by novel coronavirus SARS-Cov2 is a severe and urgent global concern. In the absence of effective treatments, the main containment strategy is to reduce the contagion by the isolation of infected individuals; however, isolation of unaffected individuals is highly undesirable. To help make rapid decisions on treatment and isolation needs, it would be useful to determine which features presented by suspected infection cases are the best predictors of a positive diagnosis. This can be done by analyzing patient characteristics, case trajectory, comorbidities, symptoms, diagnosis, and outcomes. We developed a model that employed supervised machine learning algorithms to identify the presentation features predicting COVID-19 disease diagnoses with high accuracy. Features examined included details of the individuals concerned, e.g., age, gender, observation of fever, history of travel, and clinical details such as the severity of cough and incidence of lung infection. We implemented and applied several machine learning algorithms to our collected data and found that the XGBoost algorithm performed with the highest accuracy (>85%) to predict and select features that correctly indicate COVID-19 status for all age groups. Statistical analyses revealed that the most frequent and significant predictive symptoms are fever (41.1%), cough (30.3%), lung infection (13.1%) and runny nose (8.43%). While 54.4% of people examined did not develop any symptoms that could be used for diagnosis, our work indicates that for the remainder, our predictive model could significantly improve the prediction of COVID-19 status, including at early stages of infection. url: https://api.elsevier.com/content/article/pii/S0957417420304851 doi: 10.1016/j.eswa.2020.113661 id: cord-295216-eff02z0i author: Ahluwalia, Ranbir title: The impact of imposed delay in elective pediatric neurosurgery: an informed hierarchy of need in the time of mass casualty crisis date: 2020-05-20 words: 5228.0 sentences: 327.0 pages: flesch: 46.0 cache: ./cache/cord-295216-eff02z0i.txt txt: ./txt/cord-295216-eff02z0i.txt summary: While some recommendations apply to neurosurgery, particularly endoscopic sinonasal and skull base recommendations [2] , no manuscripts exist to systematically stratify risk associated with delay in common pediatric neurosurgical procedures. Urgent cases that present an immediate threat to the patient''s life or neurologic well-being (e.g., shunt malfunction, acute hematoma evacuation, tumor with hydrocephalus, empyema, spinal cord compression) are straightforward and undergo prompt surgical intervention. [27] of the membership of the American Society of Pediatric Neurosurgery (ASPN) demonstrated a strong preference for using presence of a syrinx regardless of symptoms in the setting of Chiari I malformation as a threshold for surgery [27] . In a cohort of 35 patients with total obstetric brachial palsy injury, younger age at the time of surgery correlated with better functional recovery (r = − 0.356, p = 0.049), particularly with finger and thumb flexion [59] . Patients with Chiari malformation type I presenting with acute neurological deficits: case series abstract: SARS-CoV-2 COVID-19, coronavirus, has created unique challenges for the medical community after national guidelines called for the cancellation of all elective surgery. While there are clear cases of elective surgery (benign cranial cosmetic defect) and emergency surgery (hemorrhage, fracture, trauma, etc.), there is an unchartered middle ground in pediatric neurosurgery. Children, unlike adults, have dynamic anatomy and are still developing neural networks. Delaying seemingly elective surgery can affect a child’s already vulnerable health state by further impacting their neurocognitive development, neurologic functioning, and potential long-term health states. The purpose of this paper is to demonstrate that “elective” pediatric neurosurgery should be risk-stratified, and multi-institutional informed guidelines established. url: https://doi.org/10.1007/s00381-020-04671-x doi: 10.1007/s00381-020-04671-x id: cord-329856-0m5mc320 author: Ahmad, Shandar title: Potential of age distribution profiles for the prediction of COVID-19 infection origin in a patient group date: 2020-06-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic is a serious and global public health concern. It is now well known that COVID-19 cases may result in mild symptoms leading to patient recovery. However, severity of infection, fatality rates, and treatment responses across different countries, age groups, and demographic groups suggest that the nature of infection is diverse, and a timely investigation of the same is needed for evolving sound treatment and preventive strategies. This paper reports an the analysis of age distribution patterns in six groups of Indian COVID-19 patient populations based on their likely geographical origin of infection viz. the United Kingdom, North America, the European Union, the Middle East, and Asian countries. It was observed that patient groups stratified in this way had a distinct age profile and that some of these groups e.g. patient groups from Asia, the European Union, and the United Kingdom formed a different cluster than those from North America, the Middle East, and other regions. Patient age profiles of a population were found to be highly predictive of the group they belong to, and there are indications of their distinct recovery and fatality rates across gender. Altogether this study provides a scalable framework to estimate the source of infection in a new population of COVID-19 patients with unknown origin. It is also concluded that greater public availability of age and other demographic profile details of patients may be helpful in gaining robust insights into COVID-19 infection origins. Datasets and scripts used in this work are shared at http://covid.sciwhylab.org. url: https://www.ncbi.nlm.nih.gov/pubmed/32835072/ doi: 10.1016/j.imu.2020.100364 id: cord-310917-9sk8gdh8 author: Ahmed, Kamran title: Global challenges to urology practice during the COVID‐19 pandemic date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Since the first report of coronavirus commonly termed as COVID-19 in China, it has progressed into a pandemic and Italy has been one of the countries worst hit. Coronaviruses are enveloped ribonucleic acid (RNA) viruses that cause respiratory, entero-hepatic, and neurologic diseases in humans and mammals. More specifically the coronavirus causing the current pandemic is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The common symptoms include a dry continuous cough, fever and shortness of breath; severe cases involve pneumonia which may require ventilatory support. url: https://www.ncbi.nlm.nih.gov/pubmed/32275792/ doi: 10.1111/bju.15082 id: cord-300183-z3fwtwqb author: Ahmed, Taha title: Community and healthcare system-related factors feeding the phenomenon of evading medical attention for time-dependent emergencies during COVID-19 crisis date: 2020-08-25 words: 3444.0 sentences: 214.0 pages: flesch: 50.0 cache: ./cache/cord-300183-z3fwtwqb.txt txt: ./txt/cord-300183-z3fwtwqb.txt summary: Moreover, a comprehensive review of literature is performed to illustrate the potential factors delaying and decreasing timely presentations and interventions for time-dependent medical emergencies like ST-segment elevation myocardial infarction (STEMI). Moreover, a comprehensive review of literature is performed to illustrate the potential factors delaying and decreasing timely presentations and interventions for time-dependent medical emergencies like ST-segment elevation myocardial infarction (STEMI). There is a delay and decrease in presentations and timely interventions for medical emergencies like STEMI during the current era of COVID-19 crisis. ► Several community and healthcare-system-related factors delay and decrease the presentation and intervention for time-dependent non-communicable diseases such as STsegment elevation myocardial infarction (STEMI) in the era of COVID-19 crisis. Delayed Presentation of Acute ST Segment Elevation Myocardial Infarction Complicated with Heart Failure in the Period of COVID-19 Pandemic -Case Report Complication of late presenting STEMI due to avoidance of medical care during the COVID-19 pandemic abstract: The current COVID-19 crisis has significantly impacted healthcare systems worldwide. There has been a palpable increase in public avoidance of hospitals, which has interfered in timely care of critical cardiovascular conditions. Complications from late presentation of myocardial infarction, which had become a rarity, resurfaced during the pandemic. We present two such encounters that occurred due to delay in seeking medical care following myocardial infarction due to the fear of contracting COVID-19 in the hospital. Moreover, a comprehensive review of literature is performed to illustrate the potential factors delaying and decreasing timely presentations and interventions for time-dependent medical emergencies like ST-segment elevation myocardial infarction (STEMI). We emphasise that clinicians should remain vigilant of encountering rare and catastrophic complications of STEMI during this current era of COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32843473/ doi: 10.1136/bcr-2020-237817 id: cord-304248-sxbyxnxn author: Aiolfi, Alberto title: MANAGEMENT OF PERSISTENT PNEUMOTHORAX WITH THORACOSCOPY AND BLEBS RESECTION IN COVID-19 PATIENTS date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Several studies have been published describing the clinical and radiographic findings on the novel coronavirus (COVID-19) pneumonia. Therefore, there is currently a lack of pathologic data about its effects in intubated patients. Pneumothorax may occur rarely and results from a combination of fibrotic parenchyma with prolonged high-pressure ventilation. Chest drain represent the first line treatment. However, in case of persistent pneumothorax, thoracoscopy and bleb resection may be a feasible option to reduce air leak and improve ventilation. We report the cases of two COVID-19 patients successfully treated with thoracoscopy, bleb resection, and pleurectomy for persistent pneumothorax. url: https://api.elsevier.com/content/article/pii/S0003497520306044 doi: 10.1016/j.athoracsur.2020.04.011 id: cord-285588-ug7upa3r author: Ajibade, Ayomikun title: Telemedicine in cardiovascular surgery during COVID‐19 pandemic: A systematic review and our experience date: 2020-08-16 words: 4136.0 sentences: 196.0 pages: flesch: 39.0 cache: ./cache/cord-285588-ug7upa3r.txt txt: ./txt/cord-285588-ug7upa3r.txt summary: [23] [24] [25] TM has already been adapted into primary care, with telephone consultations and home-monitoring systems already are in regular use in general practice, however, with the adjustments made to secondary and tertiary care services in the COVID-19 era, it is unclear as to whether TM can meet the needs of complex specialities such as cardiovascular surgery. 48 While some trials show that superiority of using TM over conventional management may be debatable, the majority of the research indicates that the monitoring of clinical parameters of cardiac patients during COVID-19 is likely to be useful in not only the overall management of the changing health status of patients, but also more specifically in facilitating effective remote presurgical triaging, detecting cardiac deterioration, and managing potential postsurgical complications. Combinations of regular virtual consultations and remote monitoring of clinical parameters are feasible for cardiac surgery patients and would be useful to assess and triage before surgery. abstract: OBJECTIVE: The SAR‐COV‐2 pandemic has had an unprecedented effect on the UK's healthcare systems. To reduce spread of the virus, elective treatments and surgeries have been postponed or canceled. There has been a rise in the use of telemedicine (TM) as an alternative way to carry outpatient consultations. This systematic review aims to evaluate the extent to which TM may be able to support cardiac and vascular surgery patients in the COVID‐19 era. METHODS: We looked into how TM can support the management of patients via triaging, preoperative, and postoperative care. Evaluations targeted the clinical effectiveness of common TM methods and the feasibility of applying those methods in the UK during this pandemic. RESULTS: Several studies have published their evidence on the benefit of TM and its benefit during COVID‐19, the data related to cardiovascular surgery and how this will impact future practice of this speciality is emerging and yet larger studies with appropriate timing of outcomes to be published. CONCLUSION: Overall, the use of virtual consultations and remote monitoring is feasible and best placed to support these patients via triaging and postoperative monitoring. However, TM can be limited by the need of sophisticated technological requirement and patients’ educational and know‐how computer literacy level. url: https://doi.org/10.1111/jocs.14933 doi: 10.1111/jocs.14933 id: cord-304090-l5rocsk5 author: Akbar, Aelia title: A Cross-Sectional Survey on Telemedicine Use for Doctor-Patient Communication date: 2020-09-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction Use of computers for doctor-patient communication is increasing. Considering effective doctor-patient communication is important for good health outcomes. This study helps to determine the level of acceptance of telemedicine in general public and factors associated with it. Methods: This survey with cross-sectional analysis comprised a brief survey with 15 questions. The survey was distributed in public places to determine the opinions of the general public. Results Randomly selected 125 participants completed the questionnaire. Synchronous telemedicine was favored by young people (82% in the 18-34 age group vs 37.5% of participants aged >55 years; p<0.01), those with a higher education level (46.7% of non-college-educated persons vs 80.6% of college-educated persons; p<0.01), and frequent computer users (67% who used a computer for less than two hours a month vs 86.5% of those who used a computer more than hours a month; p=0.03). Asynchronous communication, like sending health information to doctors via a safe portal was acknowledged mostly by people who had used patient portals in the past (84.1% vs 65.4%; p=0.02). Use of patient portals was less among older users and senior citizens (20.8% use in the age group >55 vs. 51.3% in the age group 35-53 years vs. 71% in age group 18-34 years). Receiving video education for specific health concerns was favored by those who used a computer frequently (94.6% who used a computer more than two hours a month vs 77% who used a computer less than two hours a month; p =0.02). Conclusion Telemedicine is generally favored, but physicians should be mindful about older people as they may not feel comfortable. Step by step guidance should be provided especially to senior citizens for telemedicine and portal use. url: https://www.ncbi.nlm.nih.gov/pubmed/32953359/ doi: 10.7759/cureus.10402 id: cord-347058-kejcwlng author: Akbari, Hamed title: The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis date: 2020-07-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: AIMS: This study aimed to make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones. MATERIALS AND METHODS: Relevant studies were searched in PubMed, Embase, Scopus, and Web of Science databases until March 31, 2020. Cochrane's Q test and the I(2) statistic were used to determine heterogeneity. We used the random-effect models to pool the weighted mean differences (WMDs) and 95% confidence intervals (CIs). KEY FINDINGS: Out of a total of 8557 initial records, 44 articles (50 studies) with 7865 patients (ranging from 13 to 1582), were included. Our meta-analyses with random-effect models showed a significant decrease in lymphocytes, monocyte, CD4+ T cells, CD8+ T cells, CD3 cells, CD19 cells, and natural killer (NK) cells and an increase in the white blood cell (WBC), neutrophils, neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP)/hs-CRP, erythrocyte sedimentation rate (ESR), ferritin, procalcitonin (PCT), and serum amyloid A (SAA), interleukin-2 (IL-2), IL-2R, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (INF-γ) in the severe group compared to the non-severe group. However, no significant differences were found in IL-1β, IL-17, and CD4/CD8 T cell ratio between the two groups. SIGNIFICANCE: Decrease in total lymphocytes and lymphocyte subsets as well as the elevation of CRP, ESR, SAA, PCT, ferritin, and cytokines, but not IL-1β and IL-17, were closely associated with COVID-19 severity, implying reliable indicators of severe COVID-19. url: https://www.sciencedirect.com/science/article/pii/S002432052030919X?v=s5 doi: 10.1016/j.lfs.2020.118167 id: cord-311752-stqrf50k author: Akbariqomi, Mostafa title: Clinical characteristics and outcome of hospitalized COVID-19 patients with diabetes: A single-center, retrospective study in Iran date: 2020-09-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Aim To describe the epidemiological and clinical characteristics along with outcomes of hospitalized Coronavirus Disease 2019 (COVID-19) patients with and without diabetes. Methods This retrospective, single-center study included 595 consecutive hospitalized patients with confirmed COVID-19 at Baqiyatallah Hospital in Tehran, Iran, from February 26, 2020 to March 26, 2020. Demographic data, clinical, laboratory, and radiological findings were collected and compared between patients based on diabetes status. Complications and clinical outcomes were followed up until April 4, 2020. Results From among the 595 hospitalized patients with COVID-19, the median age was 55 years and 401 (67.4%) were male. The most common symptoms included fever (419 [70.4%]), dry cough (368 [61.8%]) and dyspnea (363 [61%]). A total of 148 patients (24.9%) had diabetes, and compared with patients without diabetes, these patients had more comorbidities (eg, hypertension [48.6% vs. 22.3%; P <.001]); had higher levels of white blood cell count, neutrophil count, C-reactive protein, erythrocyte sedimentation rate and blood urea nitrogen, and had a higher proportion of patchy ground-glass opacity in chest computed tomography findings (52.7% vs. 25.7%; P <.001). Significantly, patients with diabetes had more complications and needed more respiratory support than those without diabetes (P <.001). At the end of the follow-up, treatment failure and death was significantly higher in patients with diabetes compared to those without diabetes (17.8% vs. 8.7%; P = 0.003). Conclusion COVID-19 patients with diabetes are at a higher risk of complications and a higher in-hospital mortality during hospitalization. Diabetes status of COVID-19 patients and frequent monitoring of glycemia would be helpful to prevent deteriorating clinical conditions. url: https://www.sciencedirect.com/science/article/pii/S0168822720307208?v=s5 doi: 10.1016/j.diabres.2020.108467 id: cord-256117-t9v1hng5 author: Al Kasab, Sami title: Acute Stroke Management During the Coronavirus Disease 2019 (COVID-19) Pandemic: From Trough of Disillusionment to Slope of Enlightenment date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.wneu.2020.04.153 doi: 10.1016/j.wneu.2020.04.153 id: cord-354168-omen8vvq author: Al Saleh, Abdullah S. title: Multiple Myeloma in the Time of COVID-19 date: 2020-04-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We provide our recommendations (not evidence based) for managing multiple myeloma patients during the pandemic of COVID-19. We do not recommend therapy for smoldering myeloma patients (standard or high risk). Screening for COVID-19 should be done in all patients before therapy. For standard-risk patients, we recommend the following: ixazomib, lenalidomide, and dexamethasone (IRd) (preferred), cyclophosphamide lenalidomide and dexamethasone (CRd), daratumumab lenalidomide and dexamethasone (DRd), lenalidomide, bortezomib, and dexamethasone (RVd), or cyclophosphamide, bortezomib, and dexamethasone (CyBorD). For high-risk patients we recommend carfilzomib, lenalidomide, and dexamethasone (KRd) (preferred) or RVd. Decreasing the dose of dexamethasone to 20 mg and giving bortezomib subcutaneously once a week is recommended. We recommend delaying autologous stem cell transplant (ASCT), unless the patient has high-risk disease that is not responding well, or if the patient has plasma cell leukemia (PCL). Testing for COVID-19 should be done before ASCT. If a patient achieves a very good partial response or better, doses and frequency of drug administration can be modified. After 10–12 cycles, lenalidomide maintenance is recommended for standard-risk patients and bortezomib or ixazomib are recommended for high-risk patients. Daratumumab-based regimens are recommended for relapsed patients. Routine ASCT is not recommended for relapse during the epidemic unless the patient has an aggressive relapse or secondary PCL. Patients on current maintenance should continue their therapy. url: https://doi.org/10.1159/000507690 doi: 10.1159/000507690 id: cord-331481-zeaqi1uc author: Al-Ani, Fatimah title: Thrombosis risk associated with COVID-19 infection. A scoping review date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Infection by the 2019 novel coronavirus (COVID-19) has been reportedly associated with a high risk of thrombotic complications. So far information is scarce and rapidly emerging. METHODS: We conducted a scoping review using a single engine search for studies assessing thrombosis and coagulopathy in COVID-19 patients. Additional studies were identified by secondary review and alert services. RESULTS: Studies reported the occurrence of venous thromboembolism and stroke in approximately 20% and 3% of patients, respectively. A higher frequency seems to be present in severely ill patients, in particular those admitted to intensive care units. The thrombotic risk is elevated despite the use of anticoagulant prophylaxis but optimal doses of anticoagulation are not yet defined. Although and increase of biomarkers such as D-dimer has been consistently reported in severely ill COVID-19, the optimal cut-off level and prognostic value are not known. DISCUSSION: A number of pressing issues were identified by this review, including defining the true incidence of VTE in COVID patients, developing algorithms to identify those susceptible to develop thrombotic complications and severe disease, determining the role of biomarkers and/or scoring systems to stratify patients' risk, designing adequate and feasible diagnostic protocols for PE, establishing the optimal thromboprophylaxis strategy, and developing uniform diagnostic and reporting criteria. url: https://api.elsevier.com/content/article/pii/S0049384820302115 doi: 10.1016/j.thromres.2020.05.039 id: cord-283215-dgysimh5 author: Al-Jabir, Ahmed title: Impact of the coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation) date: 2020-05-12 words: 9055.0 sentences: 492.0 pages: flesch: 43.0 cache: ./cache/cord-283215-dgysimh5.txt txt: ./txt/cord-283215-dgysimh5.txt summary: Prioritisation of surgical services during this pandemic must be a careful balance of patient needs and resource availability and the European Association of Urology Guidelines Office offer the following suggestions for factors that must be taken into account [3] Whilst there have been no publication of guidelines by any professional association for the management of stone surgery during the COVID-19 pandemic, there have been some guidance published by Proietti et al [48] suggesting telephone triage of patients followed by prioritisation based on stone size and location, the presence of any obstructive uropathy, patient symptoms, presence of any stents or nephrostomy tubes and any other complicating factors such as renal failure or a solitary kidney. With guidelines specific to each specialty being implemented and followed, surgeons should be able to continue to provide safe and effective care to their patients during the COVID-19 pandemic. abstract: The Coronavirus (COVID-19) Pandemic represents a once in a century challenge to human healthcare with 2.4 million cases and 165,000 deaths thus far. Surgical practice has been significantly impacted with all specialties writing guidelines for how to manage during this crisis. All specialties have had to triage the urgency of their daily surgical procedures and consider non-surgical management options where possible. The Pandemic has had ramifications for ways of working, surgical techniques, open vs minimally invasive, theatre workflow, patient and staff safety, training and education. With guidelines specific to each specialty being implemented and followed, surgeons should be able to continue to provide safe and effective care to their patients during the COVID-19 pandemic. In this comprehensive and up to date review we assess changes to working practices through the lens of each surgical specialty. url: https://doi.org/10.1016/j.ijsu.2020.05.002 doi: 10.1016/j.ijsu.2020.05.002 id: cord-291413-cgec7150 author: Al-Jehani, Hosam title: MENA-SINO Consensus Statement on Implementing Care Pathways for Acute Neurovascular Emergencies During the COVID-19 Pandemic date: 2020-08-25 words: 3757.0 sentences: 240.0 pages: flesch: 48.0 cache: ./cache/cord-291413-cgec7150.txt txt: ./txt/cord-291413-cgec7150.txt summary: There are several challenges facing endovascular therapy for stroke, including shortages of medical staff who may be deployed for COVID-19 coverage or who may have contracted the infection and are thus quarantined, patients avoiding early medical care, a lack of personal protective equipment, delays in door-to-puncture time, anesthesia challenges, and a lack of high-intensity intensive care unit and stroke ward beds. As a leading regional neurovascular organization, the Middle East North Africa Stroke and Interventional Neurotherapies Organization (MENA-SINO) has established a task force composed of medical staff and physicians from different disciplines to establish guiding recommendations for the implementation of acute care pathways for various neurovascular emergencies during the current COVID-19 pandemic. As a leading regional neurovascular organization, the Middle East North Africa Stroke and Interventional Neurotherapies Organization (MENA-SINO) has established a task force composed of medical staff and physicians from different disciplines to establish guiding recommendations for the implementation of acute care pathways for various neurovascular emergencies during the current COVID-19 pandemic. abstract: In the unprecedented current era of the COVID-19 pandemic, challenges have arisen in the management and interventional care of patients with acute stroke and large vessel occlusion, aneurysmal subarachnoid hemorrhage, and ruptured vascular malformations. There are several challenges facing endovascular therapy for stroke, including shortages of medical staff who may be deployed for COVID-19 coverage or who may have contracted the infection and are thus quarantined, patients avoiding early medical care, a lack of personal protective equipment, delays in door-to-puncture time, anesthesia challenges, and a lack of high-intensity intensive care unit and stroke ward beds. As a leading regional neurovascular organization, the Middle East North Africa Stroke and Interventional Neurotherapies Organization (MENA-SINO) has established a task force composed of medical staff and physicians from different disciplines to establish guiding recommendations for the implementation of acute care pathways for various neurovascular emergencies during the current COVID-19 pandemic. This consensus recommendation was achieved through a series of meetings to finalize the recommendation. url: https://www.ncbi.nlm.nih.gov/pubmed/32982938/ doi: 10.3389/fneur.2020.00928 id: cord-294349-ps3qlho2 author: Al-Sharif, Eman title: Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye date: 2020-09-03 words: 7053.0 sentences: 340.0 pages: flesch: 43.0 cache: ./cache/cord-294349-ps3qlho2.txt txt: ./txt/cord-294349-ps3qlho2.txt summary: PURPOSE: Several studies have reported conflicting results on ocular manifestations and transmission of coronavirus disease 2019 (COVID-19) whose causative virus, SARS-CoV-2, belongs to the coronavirus family, the seventh recognized as a human pathogen and the third causing a severe clinical syndrome. Coronavirus disease 2019, known as COVID-19, is an emerging infection which is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that was first reported in Wuhan city, China, late in December 2019 [4] . Clinical ocular manifestations were absent in all SARS-CoV-1 patients, and viral RNA was detected in the conjunctival secretions and tears in three cases out of 120 (2.5%) with a range of 0-8% [6] [7] [8] [9] . Similarly, a small study testing the conjunctival secretions and tears (collected twice over 2-3 days) of 30 confirmed COVID-19 patients demonstrated the presence of viral RNA (in both samples) in one patient only who also showed clinical signs of conjunctivitis [12] . abstract: PURPOSE: Several studies have reported conflicting results on ocular manifestations and transmission of coronavirus disease 2019 (COVID-19) whose causative virus, SARS-CoV-2, belongs to the coronavirus family, the seventh recognized as a human pathogen and the third causing a severe clinical syndrome. COVID-19 primarily affects the lungs, similar to the other human coronaviruses. Comparing the relation between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-Cov-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye may contribute to determining their actual eye-tissue tropism and risk of ocular transmission. METHODS: Literature review was conducted via Pubmed.gov, Google Scholar and medRixv using the following keywords: COVID-19, SARS-CoV-2, SARS-CoV-1, MERS-CoV, CoV-229E, NL63, OC43, HKU1, conjunctivitis, tear swab, ocular expression, ocular symptoms and human angiotensin converting enzyme-2 expression. Studies with lack in methodology were excluded. RESULTS: Sixteen observational studies were selected. The range for detection of viral RNA in tears was 0–8% for SARS-CoV-1 and 0–5.3% for SARS-CoV-2, while no reports were found for other coronaviruses. Ocular manifestations have been reported for NL63 and SARS-CoV-2. Ocular symptoms in the form of conjunctivitis/conjunctival congestion predominantly were detected in 65 (3.17%) out of 2048 reported patients with COVID-19 (range of 0.8–32%). Eye symptoms were not reported for the other coronaviruses. CONCLUSIONS: Data aggregation for coronaviruses shows a relatively low eye-tissue tropism. Conjunctival congestion is an uncommon manifestation of COVID-19 similar to all human coronaviruses’ infections. In a low percentage of patients, the virus can be excreted in ocular fluids at different stages of the infection, regardless of positive SARS-Cov-2 throat swab. Albeit high viral loads in ocular tissue seem to have relatively low prevalence, the eye should be regarded as a potential source of infection dissemination for COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32880786/ doi: 10.1007/s10792-020-01575-2 id: cord-354160-sca9bgeq author: Al-Tawfiq, Jaffar A. title: Changes in Healthcare managing COVID and non-COVID-19 patients during the pandemic: Striking the balance date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Following the emergence of the COVID-19 pandemic, Healthcare organizations began concentrating on the preparation for and management of the surge of COVID-19 cases, while trying to protect the healthcare workers and other patients from getting COVID-19. Changing the way people work requires innovative approaches and questioning some long-held medical practices. There are multiple factors contributing to the apparent reduced utilization of healthcare services by to non-COVID-19 patients. We discuss ways to deal with preexisting chronic and COVID-19 patients at the time of the pandemic. url: https://doi.org/10.1016/j.diagmicrobio.2020.115147 doi: 10.1016/j.diagmicrobio.2020.115147 id: cord-320267-n21jryi2 author: AlShoaibi, Naeem A. title: Saudi Heart Rhythm Society Task Force on Management of Potential Arrhythmogenicity Associated with Pharmacotherapy for COVID-19 date: 2020-09-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Evidence of cardiovascular complications associated with the COVID-19 global pandemic continues to evolve. These include direct and indirect myocardial injury with subsequent acute myocardial ischemia, and cardiac arrhythmia. Some results from a limited number of trials of antiviral medications, along with chloroquine/hydroxychloroquine and azithromycin, have been beneficial. However, these pharmacotherapies may cause drug-induced QT prolongation leading to ventricular arrhythmias and sudden cardiac death. Mitigation of the potential risk in these susceptible patients may prove exceptionally challenging. The Saudi Heart Rhythm Society established a task force to perform a review of this subject based on has recently published reports, and studies and recommendations from major medical organizations. The objective of this review is to identify high-risk patients, and to set clear guidelines for management of patients receiving these pharmacotherapies. url: https://www.ncbi.nlm.nih.gov/pubmed/32954790/ doi: 10.5144/0256-4947.2020.365 id: cord-313976-q5j5kr1v author: Alaarag, Ahmed title: Clinical and angiographic characteristics of patients with STEMI and confirmed diagnosis of COVID-19: an experience of Tanta University Hospital date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Patients with established cardiovascular diseases have a poor prognosis when affected by the coronavirus disease 2019 (COVID-19). Also, the cardiovascular system, especially the heart, is affected by COVID-19. So we aimed to evaluate the angiographic and clinical characteristics of COVID-19 patients presented by ST-elevation myocardial infarction (STEMI). RESULTS: Our retrospective study showed that STEMI patients with COVID-19 had elevated inflammatory markers with mean of their CRP (89.69 ± 30.42 mg/dl) and increased laboratory parameters of thrombosis with mean D-dimer (660.15 ± 360.11 ng/ml). In 69.2% of patients, STEMI was the first clinical presentation and symptoms suggestive of COVID-19 developed during the hospital stay; about one third of patients had a non-obstructive CAD, while patients with total occlusion had a high thrombus burden. CONCLUSION: STEMI may be the initial presentation of COVID-19. A non-obstructive CAD was found in about one third of patients; on the other hand, in patients who had a total occlusion of their culprit artery, the thrombus burden was high. Identification of the underlying mechanism responsible for the high thrombus burden in these patients is important as it may result in changes in their primary management strategy, either primary PCI, fibrinolytic therapy, or a pharmaco-invasive strategy. Furthermore, adjunctive anticoagulation and antiplatelet therapy may need to be revised. url: https://doi.org/10.1186/s43044-020-00103-y doi: 10.1186/s43044-020-00103-y id: cord-294907-i836d6im author: Alabdali, Abdullah title: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak at King Abdul-Aziz Medical City-Riyadh from Emergency Medical Services Perspective date: 2020-05-20 words: 3294.0 sentences: 159.0 pages: flesch: 48.0 cache: ./cache/cord-294907-i836d6im.txt txt: ./txt/cord-294907-i836d6im.txt summary: Early in 2013, KAMC-R launched the Infection Disease Epidemic Plan (IDEP), in response to the MERS-CoV outbreak, which consists of three phases that activate based on the number of confirmed cases reported to/within the hospital. 7 Following thatthe hospital medical director initiated major actions such as isolation rooms for suspected or confirmed case, implementing a screening process for all health care workers and new patients, education and training on identifying symptoms of the disease, and means of protection. Therefore, the first steps were prevention; this included early identification of any symptoms that might encounter patients or health care workers, screening the EMS providers at the beginning of each shift and after each transport through temperature checks, followed by tacking employees sick leave records. In this experience, it was clear that paramedics needed training, and once provided, they were confident and competent in transporting critically ill positive MERS-CoV patients. abstract: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a form of an infectious respiratory disease, discovered in November 2012 in Saudi Arabia. According to the World Health Organization (WHO; Geneva, Switzerland) reports, a total of 2,519 laboratory-confirmed cases and 866 MERS-CoV-related deaths were recorded as of March 5, 2016.(1) The majority of reported cases originated from Saudi Arabia (2,121 cases). Also, MERS-CoV is believed to be of zoonotic origin and has been linked to camels in the Arabian area.(1,2) In this report, the authors discuss the lessons learned from the MERS-CoV outbreak at King Abdul-Aziz Medical City-Riyadh (KAMC-R) from August through September 2015 from the Emergency Medical Services (EMS) perspective. The discussion includes the changes in policies and paramedic’s practice, the training and education in infection control procedures, and the process of transportation of these cases. The authors hope to share their experience in this unique situation and highlight the preparedness and response efforts that took place by the division of EMS during the outbreak. url: https://doi.org/10.1017/s1049023x20000709 doi: 10.1017/s1049023x20000709 id: cord-267300-zbipv9er author: Alalwan, Adel A title: A Hemodialysis Patient with Severe COVID-19 Pneumonia date: 2020-05-06 words: 2350.0 sentences: 143.0 pages: flesch: 48.0 cache: ./cache/cord-267300-zbipv9er.txt txt: ./txt/cord-267300-zbipv9er.txt summary: Even though end-stage renal disease (ESRD) patients are particularly susceptible to COVID-19 infection and can develop severe to critical disease, there are limited studies and case reports about COVID-19 in ESRD patients. Even though ESRD patients are particularly susceptible to COVID-19 infection and can develop severe to critical disease, there are limited studies and case reports about COVID-19 in ESRD patients. We report a case of an ESRD patient on regular hemodialysis with severe COVID-19 pneumonia. This report describes the clinical presentation of this disease in a hemodialysis patient, the diagnostic process, the laboratory and imaging investigations, as well as the course of treatment. reported five cases of COVID-19 disease in hemodialysis patients in Zhongnan Hospital of Wuhan University. Lopinavir-ritonavir and Ribavirin have been used successfully as monotherapies in the treatment of mild COVID-19 pneumonia in hemodialysis patients [8, 10] . COVID-19 in hemodialysis patients: a report of 5 cases abstract: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a novel coronavirus that has spread rapidly, resulting in a worldwide pandemic. Even though end-stage renal disease (ESRD) patients are particularly susceptible to COVID-19 infection and can develop severe to critical disease, there are limited studies and case reports about COVID-19 in ESRD patients. We report a case of a 63-year-old gentleman with ESRD on regular hemodialysis. We describe the clinical presentation of this patient, the diagnostic process, the laboratory and imaging investigations, as well as the course of treatment. He positively responded to a 14-day course of Lopinavir-Ritonavir, Ribavirin, Azithromycin, and Hydroxychloroquine. url: https://www.ncbi.nlm.nih.gov/pubmed/32391234/ doi: 10.7759/cureus.7995 id: cord-324619-y7gilopu author: Alam, S.B. title: Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) causes a highly contagious respiratory disease referred to as COVID‐19. However, emerging evidence indicates that a small, but a growing number of COVID‐19 patients also manifest neurological symptoms, suggesting that SARS‐CoV‐2 may infect the nervous system under some circumstances. SARS‐CoV‐2 primarily enters the body through the epithelial lining of the respiratory and gastrointestinal tracts, but under certain conditions this pleiotropic virus may also infect peripheral nerves and gain entry into the central nervous system (CNS). The brain is shielded by various anatomical and physiological barriers, most notably the blood‐brain barrier (BBB) which functions to prevent harmful substances, including pathogens and pro‐inflammatory mediators, from entering the brain. The BBB is composed of highly specialized endothelial cells, pericytes, mast cells and astrocytes that form the neurovascular unit, which regulates BBB permeability and maintains the integrity of the CNS. In this review, we briefly discuss potential routes of viral entry and the possible mechanisms utilized by SARS‐CoV‐2 to penetrate the CNS, either by disrupting the BBB or infecting the peripheral nerves and using the neuronal network to initiate neuroinflammation. Furthermore, we speculate on the long‐term effects of SARS‐CoV‐2 infection on the brain and in the progression of neurodegenerative diseases known to be associated with other human coronaviruses. Although the mechanisms of SARS‐CoV‐2 entry into the CNS and neurovirulence are currently unknown, the potential pathways described here might pave the way for future research in this area and enable the development of better therapeutic strategies. url: https://doi.org/10.1111/ene.14442 doi: 10.1111/ene.14442 id: cord-316083-f1h2j6jx author: Alamri, Ahmad title: nan date: 2020-05-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0755498220300154?v=s5 doi: 10.1016/j.lpm.2020.104027 id: cord-318094-losjbgn6 author: Alan, Nima title: Inter-facility transfer of patients with traumatic intracranial hemorrhage and GCS 14–15: The pilot study of a screening protocol by neurosurgeon to avoid unnecessary transfers date: 2020-10-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We sought to evaluate feasibility and cost-reduction potential of a pilot screening program involving neurosurgeon tele-consultation for inter-facility transfer decisions in TBI patients with GCS 14–15 and abnormal CT head at a community hospital. The authors performed a retrospective comparative analysis of two patient cohorts during the pilot at a large hospital system from 2015 to 2017. In “screened” patients (n = 85), images and examination were reviewed remotely by a neurosurgeon who made recommendations regarding transfer to a level 1 trauma center. In the “unscreened” group (n = 39), all patients were transferred. Baseline patient characteristics, outcomes, and costs were reviewed. Patient demographics were similar between cohorts. Traumatic subarachnoid hemorrhage was more common in screened patients (29.4% vs 12.8%, P = 0.02). The presence of midline shift >5 mm was comparable between groups. Among screened patients, 5 were transferred (5.8%) and one required evacuation of chronic subdural hematoma. In unscreened patients, 7 required evacuation of subdural hematoma. None of the screened patients who were not transferred deteriorated. Screened patients had significantly reduced average total cost compared to unscreened patients ($2,003 vs. $4,482, P = 0.03) despite similar lengths of stay (2.6 vs. 2.7 days, P = 0.85). In non-surgical patients, costs were less in the screened group ($2,025 vs. $2,939), although statistically insignificant (P = 0.38). In this pilot study, remote review of images and examination by a neurosurgeon was feasible to avoid unnecessary transfer of patients with traumatic intracranial hemorrhage and GCS 14–15. The true potential in cost-reduction will be realized in system-wide large-scale implementation. url: https://www.sciencedirect.com/science/article/pii/S0967586820315290 doi: 10.1016/j.jocn.2020.09.050 id: cord-328068-qoz85x3r author: Alanio, Alexandre title: The presence of Pneumocystis jirovecii in critically ill patients with COVID-19 date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0163445320306940?v=s5 doi: 10.1016/j.jinf.2020.10.034 id: cord-339956-o5o2yz1u author: Albahri, O.S. title: Helping Doctors Hasten COVID-19 Treatment: Towards a Rescue Framework for the Transfusion of Best Convalescent Plasma to the Most Critical Patients based on Biological Requirements via ML and Novel MCDM Methods date: 2020-06-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: CONTEXT: People who have recently recovered from the threat of deteriorating coronavirus disease-2019 (COVID-19) have antibodies to the coronavirus circulating in their blood. Thus, the transfusion of these antibodies to deteriorating patients could theoretically help boost their immune system. Biologically, two challenges need to be surmounted to allow convalescent plasma (CP) transfusion to rescue the most severe COVID-19 patients. First, convalescent subjects must meet donor selection plasma criteria and comply with national health requirements and known standard routine procedures. Second, multi-criteria decision-making (MCDM) problems should be considered in the selection of the most suitable CP and the prioritisation of patients with COVID-19. OBJECTIVE: This paper presents a rescue framework for the transfusion of the best CP to the most critical patients with COVID-19 on the basis of biological requirements by using machine learning and novel MCDM methods. METHOD: The proposed framework is illustrated on the basis of two distinct and consecutive phases (i.e. testing and development). In testing, ABO compatibility is assessed after classifying donors into the four blood types, namely, A, B, AB and O, to indicate the suitability and safety of plasma for administration in order to refine the CP tested list repository. The development phase includes patient and donor sides. In the patient side, prioritisation is performed using a contracted patient decision matrix constructed between ‘serological/protein biomarkers and the ratio of the partial pressure of oxygen in arterial blood to fractional inspired oxygen criteria’ and ‘patient list based on novel MCDM method known as subjective and objective decision by opinion score method’. Then, the patients with the most urgent need are classified into the four blood types and matched with a tested CP list from the test phase in the donor side. Thereafter, the prioritisation of CP tested list is performed using the contracted CP decision matrix. RESULT: An intelligence-integrated concept is proposed to identify the most appropriate CP for corresponding prioritised patients with COVID-19 to help doctors hasten treatments. DISCUSSION: The proposed framework implies the benefits of providing effective care and prevention of the extremely rapidly spreading COVID-19 from affecting patients and the medical sector. url: https://www.ncbi.nlm.nih.gov/pubmed/32593060/ doi: 10.1016/j.cmpb.2020.105617 id: cord-302695-vyo3w2a4 author: Albertini, Laetitia title: Observational study on off-label use of tocilizumab in patients with severe COVID-19 date: 2020-09-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: In December 2019 a novel coronavirus designated SARS-CoV-2 was identified, and the disease COVID-19 has caused many deaths. SARS-CoV-2 infection has been associated with the development of cytokine storm (including interleukin 6 (IL-6)), which can cause lung damage and lack of oxygen. Tocilizumab (TCZ) inhibits ligand binding to the IL-6 receptor and may be a potential treatment for the hyperinflammation symptoms of COVID-19. However, data regarding the efficacy of TCZ in COVID-19 are lacking. The rapid spread of the pandemic in France, especially in the Paris region, constrained us to the off-label use of TCZ in patients with severe clinical conditions. METHODS: A single-centre observational cohort study of 44 patients infected with COVID-19 was carried out between 6 April and 21 April 2020 in Groupe Hospitalier Intercommunal Le Raincy-Montfermeil (GHILRM). Twenty-two patients diagnosed with COVID-19 were treated with TCZ and were compared with 22 patients not treated with TCZ matched for age, gender and length of hospital stay for COVID-19. Respiratory rate and oxygen supplementation as well as laboratory parameters (such as C-reactive protein (CRP), aspartate aminotransferase and alanine aminotransferase) were collected at baseline and during 14 days of follow-up. Our primary objective was to assess the efficacy of TCZ on respiratory clinical conditions. FINDINGS: The average respiratory rate was lower in the TCZ group than in the control group (21.5 vs 25.5 breaths/min at day 14, 95% CI −7.5 to −0.4; p=0.03). Treated patients tended to be intubated less during the course of the disease (2/22 vs 6/22, 95% CI −0.4 to 0.1; p=0.12). In each group, 10 patients no longer required oxygen therapy. We found a significant decrease in CRP in treated patients on day 7 (p=0.04). TCZ caused cytolysis in more than half (14/22) of the patients but without clinical impact. INTERPRETATION: There was a significant difference in the respiratory rate on day 14 of follow-up, with a greater decrease observed in the treated group. Fewer patients required mechanical ventilation in the TCZ group, especially among patients with more extensive CT lung damage, than in the control group. The same number of patients were weaned off oxygen on day 14 in the two groups, while the patients in the TCZ group had more severe impairment at inclusion. We consider that TCZ showed significant control of the biological inflammatory syndrome, suggesting that it may limit the effect of the cytokine storm. Our study seems to indicate the efficacy of TCZ, particularly in patients with severe initial pulmonary impairment. Selecting the best candidates and the best timing for TCZ therapy needs to be determined in randomised clinical trials. url: https://www.ncbi.nlm.nih.gov/pubmed/32912961/ doi: 10.1136/ejhpharm-2020-002414 id: cord-310205-j57x9ke6 author: Alcaide, Maria L. title: Pharyngitis and Epiglottitis date: 2007-06-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Acute pharyngitis is one of the most common illnesses for which patients visit primary care physicians. Most cases are of viral origin, and with few exceptions these illnesses are both benign and self-limited. The most important bacterial cause is the beta-hemolytic group A streptococcus. There are other uncommon or rare types of pharyngitis. For some of these treatment is required or available, and some may be life threatening. Among those discussed in this article are diphtheria, gonorrhea, HIV infection, peritonsillar abscess, and epiglottitis. url: https://www.ncbi.nlm.nih.gov/pubmed/17561078/ doi: 10.1016/j.idc.2007.03.001 id: cord-275110-safr9z37 author: Alexander, Paul Elias title: COVID-19 research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine date: 2020-04-21 words: 3337.0 sentences: 169.0 pages: flesch: 45.0 cache: ./cache/cord-275110-safr9z37.txt txt: ./txt/cord-275110-safr9z37.txt summary: At this time, more than ever, the high-quality, robust, comparative evidence from ethical randomized controlled trials (RCTs) is urgently needed to assess patient-important outcomes, including mortality, morbidity, need for life support, safety, and toxicity, informing on the safe use of chloroquine or hydroxychloroquine (with and without azithromycin) in people with COVID-19. This issue of potential harmful effects and the urgent need for high-quality, methodologically robust studies also comes from a recent pre-publication (not yet peer-reviewed) of in vitro activity of hydroxychloroquine or chloroquine in combination with metformin (used in treatment of type 2 diabetes to lower blood sugar in humans) in mice (25) . The use of existing drug treatments such as chloroquine and hydroxychloroquine outside of current guidelines and recommendations may result in adverse effects, including serious illness and death, affect patients with other diseases who may benefit from its use, and hinder the ability to conduct clinical trials if there are high demands to sue these agents by clinicians and patients. abstract: What is new? KEY FINDINGS: Clinical decision-makers must be informed by the best, most trustworthy, highest-quality, robust evidence. This translates into how much confidence we can have in the research findings and thus be optimally informed for decision-making. The estimates of effect in clinical research depends on the underlying research methodology. COVID-19 disease is presenting global health systems, clinicians, and patients grave challenges. No treatment or prophylaxis currently exists for COVID-19. The overall body of COVID-19 research is very flawed methodologically. An examination of hydroxychloroquine-azithromycin research findings due to the recent media focus revealed very low-quality methodology underpins the research. Vast amounts of time and resources are being allocated to COVID-19 research, and being potentially squandered. WHAT THIS ADDS TO WHAT WAS KNOWN: Flawed methodology and sub-optimal reporting of research findings could lead to biased estimates of effect. This could lead to treatment decisions that are not optimal based on biased estimates which could harm the patient. This article provides specific suggestions for improving on the COVID-19 methods and reporting with a focus on the issues that researchers must consider in their methodology and reporting if we are to have confidence in the estimates of effect. Failure to consider harms in research could be detrimental to the patient. This article focuses on the potential harms when therapeutic agents such as hydroxychloroquine, are being considered. WHAT IS THE IMPLICATION AND WHAT SHOULD CHANGE NOW: Research thus far on finding an optimal therapeutic agent (s) for COVID-19 could be hampered by methodologically flawed research. COVID-19 researchers must immediately and acutely focus on improving their methodology and reporting. url: https://www.sciencedirect.com/science/article/pii/S0895435620303711?v=s5 doi: 10.1016/j.jclinepi.2020.04.016 id: cord-315195-m2xqlct8 author: Alfano, Gaetano title: Peritoneal dialysis in the time of coronavirus disease 2019 date: 2020-07-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In the current setting of global containment, peritoneal dialysis (PD) and home haemodialysis are the best modalities of renal replacement therapy (RRT) to reduce the rate of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Considering the shorter and easier training programme of PD compared to home haemodialysis, PD appears a practical solution for patients with end-stage renal disease to reduce the risk of hospital-acquired infection. PD offers the advantage of minimizing the risk of viral transmission through interpersonal contact that commonly occurs during the haemodialysis session and while travelling from home to the haemodialysis facility using public transport services. To overcome barriers to health care access due to the containment measures for this emerging disease, telemedicine is a useful and reliable tool for delivering health care without exposing patients to the risk of contact. However, novel issues including handling of potentially infected dialysate, caregivers’ infectious risk and adequacy of PD in critically ill patients with acute respiratory distress syndrome remain to be clarified. In conclusion, PD should be preferred to the other modalities of RRT during the coronavirus disease 2019 (COVID-19) outbreak because it can be a solution to cope with the increased number of infected patients worldwide. url: https://doi.org/10.1093/ckj/sfaa093 doi: 10.1093/ckj/sfaa093 id: cord-349838-p6vfzbla author: Algwaiz, Ghada title: Real-world issues and potential solutions in HCT during the COVID-19 pandemic: Perspectives from the WBMT and the CIBMTR's Health Services and International Studies Committee date: 2020-07-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The current COVID-19 pandemic, caused by SARS-CoV-2, has impacted many facets of hematopoietic cell transplantation (HCT) in both developed and developing countries. Realizing the challenges as a result of this pandemic affecting the daily practice of the HCT centers, and the recognition of the variability in practice worldwide, the Worldwide Network for Blood & Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR) Health Services and International Studies Committee have jointly produced an expert opinion statement as a general guide to deal with certain aspects of HCT including diagnostics for SARS-CoV-2 in HCT patients, pre-and-post-HCT management, donor issues, medical tourism and facilities management. During these crucial times, which may last for months or years, the HCT community must reorganize to proceed with transplant activity in those patients who urgently require it, albeit with extreme caution.This shared knowledge may be of value to the HCT community in the absence of highquality evidence-based medicine. url: https://api.elsevier.com/content/article/pii/S1083879120304547 doi: 10.1016/j.bbmt.2020.07.021 id: cord-324666-fvk72o0p author: Alharbi, Musa title: Regression of ETV6-NTRK3 Infantile Glioblastoma After First-Line Treatment With Larotrectinib date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1200/po.20.00017 doi: 10.1200/po.20.00017 id: cord-270628-jtj30v0r author: Alharthy, Abdulrahman title: Prospective Longitudinal Evaluation of Point‐of‐Care Lung Ultrasound in Critically Ill Patients With Severe COVID‐19 Pneumonia date: 2020-08-14 words: 4249.0 sentences: 250.0 pages: flesch: 45.0 cache: ./cache/cord-270628-jtj30v0r.txt txt: ./txt/cord-270628-jtj30v0r.txt summary: [1] [2] [3] [4] [5] [6] Lung US was suggested to be particularly useful during the COVID-19 pandemic because of its ability to identify subtle lung parenchymal changes early in the course of disease, monitor the evolution of pulmonary lesions in hospitalized patients, and guide mechanical ventilation therapy in critically ill patients with acute respiratory failure and acute respiratory distress syndrome. [14] [15] [16] [17] [18] [19] [20] [21] [22] Chest computed tomography (CT) rapidly became the mainstream imaging method in the diagnosis and monitoring of COVID-19 pneumonia by identifying the typical pattern of ground glass opacities with variable infiltrates and consolidations, while showing a high correlation with laboratory detection of the virus by real-time polymerase chain reaction (RT-PCR) assays. [23] [24] [25] [26] [27] [28] [29] [30] Hence, in this study, the primary end point was to analyze the lung US findings in critically ill patients with severe COVID-19 pneumonia or admission to the ICU longitudinally throughout their disease course. abstract: OBJECTIVES: To perform a prospective longitudinal analysis of lung ultrasound findings in critically ill patients with coronavirus disease 2019 (COVID‐19). METHODS: Eighty‐nine intensive care unit (ICU) patients with confirmed COVID‐19 were prospectively enrolled and tracked. Point‐of‐care ultrasound (POCUS) examinations were performed with phased array, convex, and linear transducers using portable machines. The thorax was scanned in 12 lung areas: anterior, lateral, and posterior (superior/inferior) bilaterally. Lower limbs were scanned for deep venous thrombosis and chest computed tomographic angiography was performed to exclude suspected pulmonary embolism (PE). Follow‐up POCUS was performed weekly and before hospital discharge. RESULTS: Patients were predominantly male (84.2%), with a median age of 43 years. The median duration of mechanical ventilation was 17 (interquartile range, 10–22) days; the ICU length of stay was 22 (interquartile range, 20.2–25.2) days; and the 28‐day mortality rate was 28.1%. On ICU admission, POCUS detected bilateral irregular pleural lines (78.6%) with accompanying confluent and separate B‐lines (100%), variable consolidations (61.7%), and pleural and cardiac effusions (22.4% and 13.4%, respectively). These findings appeared to signify a late stage of COVID‐19 pneumonia. Deep venous thrombosis was identified in 16.8% of patients, whereas chest computed tomographic angiography confirmed PE in 24.7% of patients. Five to six weeks after ICU admission, follow‐up POCUS examinations detected significantly lower rates (P < .05) of lung abnormalities in survivors. CONCLUSIONS: Point‐of‐care ultrasound depicted B‐lines, pleural line irregularities, and variable consolidations. Lung ultrasound findings were significantly decreased by ICU discharge, suggesting persistent but slow resolution of at least some COVID‐19 lung lesions. Although POCUS identified deep venous thrombosis in less than 20% of patients at the bedside, nearly one‐fourth of all patients were found to have computed tomography–proven PE. url: https://www.ncbi.nlm.nih.gov/pubmed/32797661/ doi: 10.1002/jum.15417 id: cord-288606-h8pmqwmk author: Alhmoud, Eman title: Anticoagulation clinic drive-up service during COVID-19 pandemic in Qatar date: 2020-07-03 words: 1942.0 sentences: 90.0 pages: flesch: 46.0 cache: ./cache/cord-288606-h8pmqwmk.txt txt: ./txt/cord-288606-h8pmqwmk.txt summary: Among efforts to safely manage warfarin patients during this pandemic, we introduced a hospital drive-up anticoagulation testing service. Among our efforts to enhance patients'' safety and minimize contact time at the healthcare facility while maintaining standard clinical care for warfarin patients, we introduced a hospital drive-up anticoagulation testing service at Al Wakra Hospital (AWH) in Qatar. AWH drive-up anticoagulation testing service was launched in April, 2020 as part of HMC''s strategy to stay ahead of the pandemic and to assure patients who expressed concerns about visiting the anticoagulation clinic at AWH due to COVID-19 spread. This service is one of the efforts of healthcare providers to reduce the risk of exposure of anticoagulation patients to COVID-19 by reducing the contact time with the different personnel at the hospital and by maintaining those patients at a safe distance from others. abstract: Coronavirus Disease 2019 (COVID-19) is a pandemic affecting many countries worldwide. Given the increasing incidence especially in elderly and individuals with comorbid conditions, it is advised by health authorities to stay home if possible, maintain social distancing and stay away from those who are sick or could be infected. Patients with comorbidities especially cardiovascular disease are at higher risk of getting infected with COVID-19 and have worse prognosis. Among efforts to safely manage warfarin patients during this pandemic, we introduced a hospital drive-up anticoagulation testing service. This service can reduce the risk of exposure of anticoagulation patients to COVID-19 by reducing the contact time with the different personnel at the hospital and by maintaining those patients at a safe distance from others url: https://www.ncbi.nlm.nih.gov/pubmed/32621151/ doi: 10.1007/s11239-020-02206-4 id: cord-270933-ecmg8kti author: Ali, Ashaq title: COVID-19: Clinical aspects and therapeutics responses date: 2020-07-03 words: 1655.0 sentences: 102.0 pages: flesch: 51.0 cache: ./cache/cord-270933-ecmg8kti.txt txt: ./txt/cord-270933-ecmg8kti.txt summary: Furthermore our newly applied combination (Lianhuaqingwen and Arbidol Hydrochloride) showed effects in 5-7 days for patients with mild symptoms and was found effective with 98 % recovery rate. The significant alternation in laboratory findings during hospitalization was a high level of C reactive protein, lymphopenia, increases in WBC, and neutrophil count ( Both patients with mild symptoms and asymptomatic, received TCM LH Capsule in combination with Arbidol Hydrochloride tablets, with dosage and duration detail in (Table 03 ). Findings of the current study have shown that the treatment of COVID-19 patients with LH capsule in combination with Arbidol Hydrochloride resulted in significant recovery. Furthermore, the combination of LH with Aribidol hydrochloride can be used as effective therapeutics against COVID-19, specifically for Patients with mild symptoms. The effect of Arbidol Hydrochloride on reducing mortality of Covid-19 patients: a retrospective study of real world date from three hospitals in Wuhan abstract: COVID-19 has created havoc in the world by causing thousands of demises in a short period of time. Up till now, several attempts have been made for potential therapeutics against SARS-COV2. In this retrospective, single-center study, we extracted data from 122 COVID-19, RT-PCR confirmed patients. who were treated with a new treatment strategy of lianhuaqingwen with Arbidol Hydrochloride. The patients were either asymptomatic or had mild symptoms for COVID-19 disease. Of 122 patients 21 (17.21%) patients undergo severe conditions of COVID-19, However total 111 (90.9 %) experienced mild symptoms such as fever in 93 (76.22%) patients, cough in 23 (20.17%) and muscle pain were observed in total 8 (7%) patients. Furthermore our newly applied combination (Lianhuaqingwen and Arbidol Hydrochloride) showed effects in 5-7 days for patients with mild symptoms and was found effective with 98 % recovery rate. We found the new combination is very effective against patients with mild symptoms and asymptomatic patients. Further extensive clinical investigations are required. url: https://www.ncbi.nlm.nih.gov/pubmed/32788835/ doi: 10.1016/j.jsps.2020.06.022 id: cord-254377-j8e8gb0l author: Ali, Sadaf title: Acute cor pulmonale from saddle pulmonary embolism in a patient with previous Covid-19 – should we prolong prophylactic anticoagulation? date: 2020-06-13 words: 1447.0 sentences: 87.0 pages: flesch: 43.0 cache: ./cache/cord-254377-j8e8gb0l.txt txt: ./txt/cord-254377-j8e8gb0l.txt summary: However, the risk associated with mild and moderate illness from Covid-19 is unknown, and there is no current recommendation for prophylaxis against thromboembolism in patients after hospital treatment unless there are established thrombophilic risk factors. We report the case of a 52-year old woman, who presented with massive saddle pulmonary embolism after one week of initial hospital discharge, successfully thrombolysed that raises the question of consideration of extended prophylactic anticoagulation even in low risk Covid-19 cases. 3 We report a case of acute massive PE successfully managed by thrombolysis in a patient who was discharged after one week of initial hospital treatment for Covid-19 pneumonia which raises serious concerns about the indication for extended prophylactic anticoagulation in such cases. Emerging data and clinical experience suggest an increased prevalence of venous thromboembolic events (VTE) in COVID-19, especially in patients with severe disease requiring hospitalization, and even among those who are not critically ill. abstract: Abstract Severe corona virus disease 19 (Covid-19) is known to be associated with exaggerated risk of thromboembolism. However, the risk associated with mild and moderate illness from Covid-19 is unknown, and there is no current recommendation for prophylaxis against thromboembolism in patients after hospital treatment unless there are established thrombophilic risk factors. We report the case of a 52-year old woman, who presented with massive saddle pulmonary embolism after one week of initial hospital discharge, successfully thrombolysed that raises the question of consideration of extended prophylactic anticoagulation even in low risk Covid-19 cases. url: https://api.elsevier.com/content/article/pii/S1201971220304744 doi: 10.1016/j.ijid.2020.06.039 id: cord-017217-zjab7o2o author: Ali, Yousaf title: Self Assessment Questions date: 2008-01-08 words: 9298.0 sentences: 715.0 pages: flesch: 52.0 cache: ./cache/cord-017217-zjab7o2o.txt txt: ./txt/cord-017217-zjab7o2o.txt summary: A 47-year-old patient with Crohn''s disease presents for evaluation of new onset arthritis. Although the patient has not had prior thromboses she is at high risk for developing antiphospholipid antibody syndrome in view of these blood tests. A 19-year-old previously healthy student is evaluated for new onset fever, joint pain, and rash. Her lab work reveals leukocytosis with lymphocytic predominance, normal renal function, mild transaminitis, and low serum albumin. Yousaf Ali, Self Assessment Questions in Rheumatology, DOI: 10.1007/ 978-1-59745-497-1, Humana Press, a part of Springer Science + Business Media, LLC 2009 A 55-year-old female with chronic renal failure is seen for evaluation of lower extremity edema and ankle pain. This 41-year-old patient presents with a 4-year history of recurrent sinusitis in the setting of a positive P-ANCA, destructive nasopharyngeal mass, and ophthalmoplegia.The differential diagnosis includes infection with a refractory organism, such as mucormycosis or tuberculosis, malignancy, midline granuloma, or vasculitis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121721/ doi: 10.1007/978-1-59745-497-1_1 id: cord-280431-tuzdng4h author: Alinier, Guillaume title: 5 Basing a Nonclinician''s Career upon Simulation The Personal Experience of a Physicist date: 2008-12-31 words: 3506.0 sentences: 149.0 pages: flesch: 41.0 cache: ./cache/cord-280431-tuzdng4h.txt txt: ./txt/cord-280431-tuzdng4h.txt summary: The triggers for this rapid growth have not only been recent technological developments in terms of personal computer power, but primarily clinical educators believing in the potential of simulation training approaches to help others effectively acquire life-saving skills in a safe and controlled environment. At the same time, I assumed responsibility for the development of the University of Hertfordshire''s Intensive Care and Emergency Simulation Center concentrating primarily on delivering simulation-based training to nursing and paramedical students and evaluating the teaching effectiveness of this approach [6] . Similarly, you can greatly contribute to the success of your center''s simulation programs by effectively communicating with other educators to refine scenarios provided to your participants, develop the simulation environment and new props. You might be able to use your skills and technical knowledge to further develop their ideas and improve aspects of the simulation training experience of participants. abstract: Publisher Summary This chapter concerns the breed of people who start by selecting a nonclinician path and eventually work in clinical simulation. Their new role requires their grasping a wide range of clinical and educational concepts and skills that should already be second nature to their new colleagues who are trained as an educator, a clinician, or health care professional. There are many different opportunities and responsibilities in the domain of clinical simulation, and nonclinicians could occupy almost any one of them. This ranges from educationalist, communication or team dynamic expert, technician, or technical manager, center coordinator, administrator, to operations manager. The background of potential simulation center employees will be an important asset in their new role as it could give them a different perspective, additional skills, and innovative ideas that complement those of their clinical colleagues. url: https://www.sciencedirect.com/science/article/pii/B9780123725318500133 doi: 10.1016/b978-012372531-8.50013-3 id: cord-340232-cadu5ah8 author: Aliter, Kholoud F. title: Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19 date: 2020-09-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Thrombin is a trypsin-like serine protease with multiple physiological functions. Its role in coagulation and thrombosis is well-established. Nevertheless, thrombin also plays a major role in inflammation by activating protease-activated receptors. In addition, thrombin is also involved in angiogenesis, fibrosis, and viral infections. Considering the pathogenesis of COVID-19 pandemic, thrombin inhibitors may exert multiple potential therapeutic benefits including antithrombotic, anti-inflammatory, and antiviral activities. In this review, we describe the clinical features of COVID-19, the thrombin’s roles in various pathologies, and the potential of argatroban in COVID-19 patients. Argatroban is a synthetic, small molecule, direct, competitive, and selective inhibitor of thrombin. It is approved to parenterally prevent and/or treat heparin-induced thrombocytopenia in addition to other thrombotic conditions. Argatroban also possesses anti-inflammatory and antiviral activities and has a well-established pharmacokinetics profile. It also appears to lack a significant risk of drug–drug interactions with therapeutics currently being evaluated for COVID-19. Thus, argatroban presents a substantial promise in treating severe cases of COVID-19; however, this promise is yet to be established in randomized, controlled clinical trials. url: https://doi.org/10.1007/s10557-020-07066-x doi: 10.1007/s10557-020-07066-x id: cord-259411-434acu0h author: Aljehani, Faisal A. title: Inpatient Diabetes and Hyperglycemia Management Protocol in the COVID-19 Era date: 2020-07-06 words: 1461.0 sentences: 80.0 pages: flesch: 45.0 cache: ./cache/cord-259411-434acu0h.txt txt: ./txt/cord-259411-434acu0h.txt summary: Here we present a flow chart (figure 1) for the management of diabetes and hyperglycemia in non-critically ill patients as an attempt to standardize a protocol that may be used across different services in the hospital without the need of a diabetes specialist. Experts have suggested that we need to revise guidelines to allow more usage of non-insulin anti-diabetic medications for hospitalized patients (14) . Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline Efficacy of basal-bolus insulin regimens in the inpatient management of non-critically ill patients with type 2 diabetes: A systematic review and meta-analysis. Debate on Insulin vs Non-insulin Use in the Hospital Setting-Is It Time to Revise the Guidelines for the Management of Inpatient Diabetes? Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery) abstract: nan url: https://api.elsevier.com/content/article/pii/S0002962920302962 doi: 10.1016/j.amjms.2020.07.005 id: cord-030897-c88tjrai author: Aljohani, Amal H. title: Clinical and Immunological Characterization of Combined Immunodeficiency Due to TFRC Mutation in Eight Patients date: 2020-08-27 words: 3484.0 sentences: 216.0 pages: flesch: 52.0 cache: ./cache/cord-030897-c88tjrai.txt txt: ./txt/cord-030897-c88tjrai.txt summary: PURPOSE: Combined immunodeficiency (CID), due to mutations in TFRC gene that encodes the transferrin receptors (TfR1), is a rare monogenic disorder. Nevertheless, the high rate of consanguineous marriages in the Saudi population [7] and the availability of advanced molecular genetic testing provided us with the opportunity to identify and review a relatively large number of patients with combined immunodeficiency due to mutated TFRC in great detail. The observed neurological involvement in some of the patients in the form of developmental delay, milestone regression, and optic atrophy could be related to recurrent infections and prolonged hospitalization, or it could be part of the disease itself, as mitochondrial iron supply may be affected by this mutation [11] [12] [13] [14] [15] [16] . Patients with WAS and TFRC gene mutations tend to have recurrent infections and thrombocytopenia. The lymphocyte requirement of transferrin and impaired TfR signaling role impaired lymphocyte proliferation to PHA in patients with TFRC gene mutations [4, 17] . abstract: PURPOSE: Combined immunodeficiency (CID), due to mutations in TFRC gene that encodes the transferrin receptors (TfR1), is a rare monogenic disorder. In this study, we further characterize the clinical and immunological phenotypes in a cohort of eight patients. METHODS: A retrospective review of clinical and immunological features of patients diagnosed with a TFRC gene mutation between 2015 and 2019 in three tertiary centers. RESULTS: Eight patients from six unrelated families were enrolled. The patients had a median age of 7 years (4–32 years). All patients presented with recurrent sinopulmonary infections, chronic diarrhea, and failure to thrive in early life. Less common features were skin abscesses, conjunctivitis, global developmental delay, optic nerve atrophy, vitiligo, multinodular goiter, and hemophagocytic lymphohistiocytosis-like symptoms. All patients had intermittent neutropenia and 87% of the patients had recurrent thrombocytopenia. Anemia was found in 62%. All patients had hypogammaglobinemia and one had a persistent high IgM level. All patients had impaired function of T cells. The same homozygous missense mutation c.58T>C:p.Y20H, in the TFRC gene, was detected in all patients. Stem cell transplantation from matched donors was successful in two patients. Five patients did not receive stem cell transplantation, and they are on prophylactic treatment. One patient died due to severe sepsis and neurological complications. CONCLUSION: This report provides a large cohort with a long follow up of patients with this disease. Our cohort showed variable disease severity. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449781/ doi: 10.1007/s10875-020-00851-1 id: cord-322534-eikz07zz author: Allahyari, Abolghasem title: Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structured summary of a study protocol for a randomised controlled trial date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: In this study, we investigate the effect of hydroxychloroquine on the prevention of Novel Coronavirus Disease (COVID-19) in cancer patients being treated. TRIAL DESIGN: This is a multi-centre, two-arm, parallel-group, triple-blind, phase 2-3 randomised controlled trial. PARTICIPANTS: All patients over the age of 15 from 5 types of cancer are included in the study. Patients with acute lymphoid and myeloid leukemias in the first line treated with curative intent, patients with high-grade non-Hodgkin's lymphoma treated with leukemia protocols and patients with non-metastatic breast and colon cancer in the first line of treatment will enter the study. The exclusion criteria will include known sensitivity to Hydroxychloroquine, weight below 35 kilograms, history of retinopathy, history of any cardiac disease, acute respiratory tract infection in the last 2 months, having COVID-19 in the first two weeks of entering the trial, having Diabetes Mellitus, having an immuno-suppressive disease other than cancer, having chronic pulmonary disease and taking immuno-suppressant drug other than chemotherapeutic agents for current cancer. This study is performed in five academic centres affiliated to Mashhad University of Medical Sciences, Mashhad, Iran. INTERVENTION AND COMPARATOR: Patients are randomly assigned to two groups; one being given hydroxychloroquine and the other is given placebo. During two months of treatment, the two groups are treated with either hydroxychloroquine (Amin® Pharmaceutical Company, Isfahan, Iran) or placebo (identical in terms of shape, colour, smell) as a single 200 mg tablet every other day. Patients will be monitored for COVID-19 symptoms during the follow-up period. If signs or symptoms occur (fever, cough, shortness of breath), they will be examined and investigated with a high-resolution computed tomography (CT) scan of the lungs, COVID-19 specific IgM, IgG antibody assay and a nucleic acid amplification test (NAT) for the SARS-CoV-2 virus. MAIN OUTCOMES: The primary end point of this study is to investigate the incidence of COVID-19 in patients being treated for their cancer over a 2-month period. RANDOMISATION: Randomisation will be performed using randomly permuted blocks. By using an online website (www.randomization.com) the randomization sequence will be produced by quadruple blocks. The allocation ratio in intervention and control groups is 1:1. BLINDING (MASKING): Participants and caregivers do not know whether the patient is in the intervention or the control group. The outcome assessor and the data analyst are also blinded to group assignment. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): The calculated total sample size is 60 patients, with 30 patients in each group. TRIAL STATUS: The trial began on April 14, 2020 and recruitment is ongoing. Recruitment is anticipated to be completed by June 14, 2020 There has been no change in study protocol since approval, protocol version 1 was approved April 12, 2020. TRIAL REGISTRATION: This trial has been registered by the title of “Effect of Hydroxychloroquine on Novel Coronavirus Disease (COVID-19) prevention in cancer patients under treatment” in Iranian Registry of Clinical Trials (IRCT) with code “IRCT20200405046958N1”, https://www.irct.ir/trial/46946. Registration date is April 14, 2020. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://doi.org/10.1186/s13063-020-04485-x doi: 10.1186/s13063-020-04485-x id: cord-312754-3yhxcfr2 author: Allen, Bradley D. title: Society for Cardiovascular Magnetic Resonance (SCMR) guidance for re-activation of cardiovascular magnetic resonance practice after peak phase of the COVID-19 pandemic date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: During the peak phase of the COVID-19 pandemic, alterations of standard operating procedures were necessary for health systems to protect patients and healthcare workers and ensure access to vital hospital resources. As the peak phase passes, re-activation plans are required to safely manage increasing clinical volumes. In the context of cardiovascular magnetic resonance (CMR), re-activation objectives include continued performance of urgent CMR studies and resumption of CMR in patients with semi-urgent and elective indications in an environment that is safe for both patients and health care workers. url: https://www.ncbi.nlm.nih.gov/pubmed/32772930/ doi: 10.1186/s12968-020-00654-8 id: cord-352193-izzqdg3v author: Allen, M. title: Organising outpatient dialysis services during the COVID-19 pandemic. A simulation and mathematical modelling study. date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background This study presents two simulation modelling tools to support the organisation of networks of dialysis services during the COVID-19 pandemic. These tools were developed to support renal services in the South of England (the Wessex region caring for 650 patients), but are applicable elsewhere. Methods A discrete-event simulation was used to model a worst case spread of COVID-19 (80% infected over three months), to stress-test plans for dialysis provision throughout the COVID-19 outbreak. We investigated the ability of the system to manage the mix of COVID-19 positive and negative patients, and examined the likely effects on patients, outpatient workloads across all units, and inpatient workload at the centralised COVID-positive inpatient unit. A second Monte-Carlo vehicle routing model estimated the feasibility of patient transport plans and relaxing the current policy of single COVID-19 patient transport to allow up to four infected patients at a time. Results If current outpatient capacity is maintained there is sufficient capacity in the South of England to keep COVID-19 negative/recovered and positive patients in separate sessions, but rapid reallocation of patients may be needed (as sessions are cleared of negative/recovered patients to enable that session to be dedicated to positive patients). Outpatient COVID-19 cases will spillover to a secondary site while other sites will experience a reduction in workload. The primary site chosen to manage infected patients will experience a significant increase in outpatients and in-patients. At the peak of infection, it is predicted there will be up to 140 COVID-19 positive patients with 40 to 90 of these as inpatients, likely breaching current inpatient capacity (and possibly leading to a need for temporary movement of dialysis equipment). Patient transport services will also come under considerable pressure. If patient transport operates on a policy of one positive patient at a time, and two-way transport is needed, a likely scenario estimates 80 ambulance drive time hours per day (not including fixed drop-off and ambulance cleaning times). Relaxing policies on individual patient transport to 2-4 patients per trip can save 40-60% of drive time. In mixed urban/rural geographies steps may need to be taken to temporarily accommodate renal COVID-19 positive patients closer to treatment facilities. Conclusions Discrete-event simulation simulation and Monte-Carlo vehicle routing model provides a useful method for stress-testing inpatient and outpatient clinical systems prior to peak COVID-19 workloads. url: http://medrxiv.org/cgi/content/short/2020.04.22.20075457v1?rss=1 doi: 10.1101/2020.04.22.20075457 id: cord-351020-wde3ki0k author: Allione, Attilio title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s11739-020-02373-5 doi: 10.1007/s11739-020-02373-5 id: cord-103659-wpwfqhp2 author: Almqvist, J. title: Neurological manifestations of coronavirus infections: a systematic review date: 2020-09-01 words: 6075.0 sentences: 463.0 pages: flesch: 46.0 cache: ./cache/cord-103659-wpwfqhp2.txt txt: ./txt/cord-103659-wpwfqhp2.txt summary: In order to optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we systematically reviewed neurological and neuroradiological manifestations of SARS-CoV-2 and all other known human coronavirus species (HCoV). . https://doi.org/10.1101/2020.08.26.20182196 doi: medRxiv preprint symptoms/complications, neuropathological findings and/or neuroimaging findings associated to acute or prior coronavirus infection. Several case reports, comprising a total of 11 patients, described neurological complications in SARS-CoV-1, among them critical illness neuro-/myopathy, seizures, persistent sleeping difficulties, persistent anosmia, delirium and generalized pain (Table e-6). Several common neurological symptoms among SARS-CoV-2 patients have been described in these studies, such as fatigue (44 -64% of patients), 42 is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint Retrospective Observational Study of Brain Magnetic Resonance Imaging Findings in Patients with Acute SARS-CoV-2 Infection and Neurological Manifestations abstract: In order to optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we systematically reviewed neurological and neuroradiological manifestations of SARS-CoV-2 and all other known human coronavirus species (HCoV). Which lessons can we learn? We identified relevant publications (until July 26h 2020) using systematic searches in PubMed, Web of Science and Ovid EMBASE with predefined search strings. A total of 4571 unique publications were retrieved, out of which 378 publications were selected for in-depth analysis by two raters, including a total of 17549 (out of which were 14418 SARS-CoV-2) patients. Neurological complications and associated neuroradiological manifestations are prevalent for all HCoVs (HCoV-229E, HKU1, NL63, OC43, Middle East respiratory syndrome (MERS)-CoV, SARS-CoV-1 and SARS-CoV-2). Moreover, there are similarities in symptomatology across different HCoVs, particularly between SARS-CoV-1 and SARS-CoV-2. Common neurological manifestations include fatigue, headache and smell/taste disorders. Additionally, clinicians need to be attentive for at least five classes of neurological complications: (1) Cerebrovascular disorders including ischemic stroke and macro/micro-hemorrhages, (2) encephalopathies, (3) para-/postinfectious immune-mediated complications such as Guillain-Barre syndrome and acute disseminated encephalomyelitis, (4) (meningo-)encephalitis, potentially with concomitant seizures and (5) neuropsychiatric complications such as psychosis and mood disorders. Our systematic review highlights the need for vigilance regarding neurological complications in patients infected by SARS-CoV-2 and other HCoVs, especially since some complications may result in chronic disability. Neuroimaging protocols should be designed to specifically screen for these complications. Therefore, we propose practical imaging guidelines to facilitate the diagnostic workup and monitoring of patients infected with HCoVs. url: http://medrxiv.org/cgi/content/short/2020.08.26.20182196v1?rss=1 doi: 10.1101/2020.08.26.20182196 id: cord-333696-3ci9re9a author: Alomari, Safwan O. title: COVID-19 and the Central Nervous System date: 2020-08-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: • As the number of patients with COVID-19 is increasing worldwide, it is necessary to stress on the importance of the atypical clinical presentations (including those related to the nervous system) of COVID-19 infection, since they might be the initial manifestations. • Literature on this regard should be sent by the international and local health committees to all health-care providers during this COVID -19 pandemic, to make sure that all providers are well informed and aware of these cases. • More studies are deeply needed to enable the concerned committees to make evidence-based guidelines for prevention, early detection and appropriate management of these cases. url: https://www.ncbi.nlm.nih.gov/pubmed/32828027/ doi: 10.1016/j.clineuro.2020.106116 id: cord-294768-bs6thjw2 author: Alonso-Fernández, Alberto title: Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study date: 2020-08-25 words: 4652.0 sentences: 278.0 pages: flesch: 49.0 cache: ./cache/cord-294768-bs6thjw2.txt txt: ./txt/cord-294768-bs6thjw2.txt summary: title: Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study CONCLUSIONS: Patients with COVID-19 pneumonia and D-dimer values higher than 1 μg/mL presented a high prevalence of PE, regardless of clinical suspicion. [12] found, in a retrospective study in 184 intensive care unit (ICU) patients with severe COVID-19 pneumonia, a high prevalence of thrombotic complications and, by far, pulmonary embolism (PE) was the most frequent. Pulmonary embolism in COVID-19 pneumonia with high D-dimer values: A prospective study procoagulant (D-dimer) markers that correlated with the extend of the thromboembolic episode compared to those patients without PE. We included patients with D-dimer values higher than 1 μg/mL, which have been associated with disease severity and in-hospital mortality in patients with COVID-19 infection. Pulmonary embolism in COVID-19 pneumonia with high D-dimer values: A prospective study of our patients, allocated in the non-PE group, was not on enoxaparin prophylaxis during hospitalization. abstract: INTRODUCTION: Coronavirus disease 2019 (COVID-19) pneumonia is associated to systemic hyper-inflammation and abnormal coagulation profile. D-dimer elevation is particularly frequent, and values higher than 1μg/mL have been associated with disease severity and in-hospital mortality. Previous retrospective studies found a high pulmonary embolism (PE) prevalence, however, it should be highlighted that diagnoses were only completed when PE was clinically suspected. MATERIAL AND METHODS: Single-center prospective cohort study. Between April 6(th) and April 17(th) 2020, consecutive confirmed cases of COVID-19 pneumonia with D-dimer >1 μg/mL underwent computed tomography pulmonary angiography (CTPA) to investigate the presence and magnitude of PE. Demographic and laboratory data, comorbidities, CTPA scores, administered treatments, and, clinical outcomes were analysed and compared between patients with and without PE. RESULTS: Thirty consecutive patients (11 women) were included. PE was diagnosed in 15 patients (50%). In patients with PE, emboli were located mainly in segmental arteries (86%) and bilaterally (60%). Patients with PE were significantly older (median age 67.0 (IQR 63.0–73.0) vs. 57.0 (IQR 48.0–69.0) years, p = .048) and did not differ in sex or risk factors for thromboembolic disease from the non-PE group. D-dimer, platelet count, and, C reactive protein values were significantly higher among PE patients. D-dimer values correlated with the radiologic magnitude of PE (p<0.001). CONCLUSIONS: Patients with COVID-19 pneumonia and D-dimer values higher than 1 μg/mL presented a high prevalence of PE, regardless of clinical suspicion. We consider that these findings could contribute to improve the prognosis of patients with COVID-19 pneumonia, by initiating anticoagulant therapy when a PE is found. url: https://doi.org/10.1371/journal.pone.0238216 doi: 10.1371/journal.pone.0238216 id: cord-338965-ewuqsfsf author: Alotaibi, Fawzia E. title: Emergence of carbapenem-resistant Enterobacteriaceae isolated from patients in a university hospital in Saudi Arabia. Epidemiology, clinical profiles and outcomes date: 2017-06-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Carbapenemase-producing Enterobacteriaceae have been steadily spreading worldwide during the last decade. Nine patients were identified prospectively and were followed during their hospitalization course to identify the epidemiology, clinical profiles and outcomes. These patients had one or more cultures positive for a CRE isolate, contributing to a total of eleven positive cultures from various sites without including duplicates of isolates obtained from the same site. Isolates from these patients included five Klebseilla pneumoniae, three Escherichia coli, and one Enterobacter aerogenes. Five isolates were grown from blood cultures, three from wound cultures, one from urine cultures, one from respiratory cultures and one from an abscess collection. Five survived the hospital course. The other five patients died due to severe sepsis, septic shock or multi-organ failure. Of the nine isolates of CRE identified for which molecular analysis were available, four K. pneumonia were confirmed as blaNDM and one as OXA-48. For the purpose of controlling the spread of CRE in our institution, we recommend considering active surveillance cultures and screening patients transferred from other hospitals or coming from highly endemic settings at admission for these organisms. url: https://www.ncbi.nlm.nih.gov/pubmed/28642140/ doi: 10.1016/j.jiph.2017.05.004 id: cord-033247-2cbslnb7 author: Alsaied, Tarek title: From Other Journals: A Review of Recent Articles in Pediatric Cardiology date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In this review, we provide a brief description of recently published articles addressing topics relevant to pediatric cardiologists. Our hope is to provide a summary of the latest articles published recently in other journals in our field. The articles address (1) outcomes after anomalous aortic origin of the coronary artery repair which showed relief of ischemia in most patients with low mortality, (2) the role of lymphatic imaging to predict post-Fontan complications which showed that lymphatic imaging by MRI may have an added prognostic value, (3) European guidelines for participation in competitive sports in congenital heart disease patients using a systematic approach based on ventricular structure and function, pulmonary pressure, aortic root, arrhythmia, and cyanosis, (4) fenestrated atrial septal defect closure combined with medical therapy in patients with severe pulmonary hypertension which resulted in improved pulmonary pressure and offered hope for this population, (5) animal model study for pulmonary vein stenosis postsurgery showing activation of the mammalian target of rapamycin pathway and that application of rapamycin at the anastomosis location may prevent pulmonary vein stenosis, and (6) mitral valve replacement with the 15-mm mechanical valve describing a 20-year multicenter experience from the Netherland that showed that this “dime valve” may be a good option for small infants with mitral valve disease. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538048/ doi: 10.1007/s00246-020-02478-w id: cord-253638-5f9ofdsc author: Alsaied, Tarek title: Coronavirus Disease 2019 (COVID‐19) Pandemic Implications in Pediatric and Adult Congenital Heart Disease date: 2020-06-10 words: 5683.0 sentences: 339.0 pages: flesch: 49.0 cache: ./cache/cord-253638-5f9ofdsc.txt txt: ./txt/cord-253638-5f9ofdsc.txt summary: Given the increased risk for severe COVID‐19 observed in adults with underlying cardiac involvement, there is concern that patients with pediatric and congenital heart disease (CHD) may likewise be at increased risk for severe infection. In this review, we describe the effects of COVID‐19 in the pediatric and young adult population and review the cardiovascular involvement in COVID‐19 focusing on implications for patients with congenital heart disease in particular. 4-Cardiac care team members are at risk for acquiring COVID-19 and may play a role in spreading the disease between patients and in the society at large. It is important to know that 3.8% of the cases reported from China were of healthcare team members suggesting that health care providers are at a significantly increased risk of contracting COVID-19 11, 83 . abstract: The corona virus disease ‐2019 (COVID‐19) is a recently described infectious disease caused by the severe acute respiratory syndrome corona virus 2 with significant cardiovascular implications. Given the increased risk for severe COVID‐19 observed in adults with underlying cardiac involvement, there is concern that patients with pediatric and congenital heart disease (CHD) may likewise be at increased risk for severe infection. The cardiac manifestations of COVID‐19 include myocarditis, arrhythmia and myocardial infarction. Importantly, the pandemic has stretched health care systems and many care team members are at risk for contracting and possibly transmitting the disease which may further impact the care of patients with cardiovascular disease. In this review, we describe the effects of COVID‐19 in the pediatric and young adult population and review the cardiovascular involvement in COVID‐19 focusing on implications for patients with congenital heart disease in particular. url: https://doi.org/10.1161/jaha.120.017224 doi: 10.1161/jaha.120.017224 id: cord-311176-dlwph5za author: Alshahrani, Mohammed S. title: Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus date: 2018-01-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS‐CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients before and after the availability of extracorporeal membrane oxygenation (ECMO) as a rescue therapy in severely hypoxemic patients who failed conventional strategies. METHODS: We collected data retrospectively on MERS-CoV patients with refractory respiratory failure from April 2014 to December 2015 in 5 intensive care units (ICUs) in Saudi Arabia. Patients were classified into two groups: ECMO versus conventional therapy. Our primary outcome was in-hospital mortality; secondary outcomes included ICU and hospital length of stay. RESULTS: Thirty-five patients were included; 17 received ECMO and 18 received conventional therapy. Both groups had similar baseline characteristics. The ECMO group had lower in-hospital mortality (65 vs. 100%, P = 0.02), longer ICU stay (median 25 vs. 8 days, respectively, P < 0.01), and similar hospital stay (median 41 vs. 31 days, P = 0.421). In addition, patients in the ECMO group had better PaO2/FiO2 at days 7 and 14 of admission to the ICU (124 vs. 63, and 138 vs. 36, P < 0.05), and less use of norepinephrine at days 1 and 14 (29 vs. 80%; and 36 vs. 93%, P < 0.05). CONCLUSIONS: ECMO use, as a rescue therapy, was associated with lower mortality in MERS patients with refractory hypoxemia. The results of this, largest to date, support the use of ECMO as a rescue therapy in patients with severe MERS-CoV. url: https://www.ncbi.nlm.nih.gov/pubmed/29330690/ doi: 10.1186/s13613-017-0350-x id: cord-289612-4x5t4c5u author: Alsuliman, Tamim title: COVID-19 paraclinical diagnostic tools: Updates and future trends date: 2020-06-20 words: 7353.0 sentences: 387.0 pages: flesch: 48.0 cache: ./cache/cord-289612-4x5t4c5u.txt txt: ./txt/cord-289612-4x5t4c5u.txt summary: Laboratory-confirmed SARS-CoV-2 infection requires the detection of viral nucleic acid in respiratory tract samples by the use of real-time reverse-transcription polymerase chain reaction (rRT-PCR) assay. In the course of this phase, upper respiratory specimens were tested by RT-PCR for viral RNA and the majority of the patients showed positive results for SARS-CoV-2. These results contrast with another German smaller study by Wolfel et al., conducted on 9 COVID-19 patients, with no discernible difference in viral loads or detection rates when comparing nasal and throat swabs [38] . found that 66.67% of laboratory-confirmed COVID-19 patients were tested positive for SARS-CoV-2 RNA in stool specimens. enrolled a total of 173 confirmed cases of COVID-19 by the use of rRT-PCR on samples from the respiratory track reported that the seroconversion sequentially appeared for the total antibody (Ab), IgM and then IgG, with a median time of 11, 12 and 14 days, respectively. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases abstract: MOTIVATION: COVID-19 is one of the most widely affecting pandemics. As for many respiratory viruses-caused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. Rapid and accurate diagnosis is vital in such a pandemic. On one side, rapidity may enhance management effectiveness, while on the other, coupling efficiency and less costly procedures may permit more effective community-scale management. METHODOLOGY AND MAIN STRUCTURE: In this review, we shed light on the most used and the most validated diagnostic tools. Furthermore, we intend to include few under-development techniques that may be potentially useful in this context. The practical intent of our work is to provide clinicians with a realistic summarized review of the essential elements in the applied paraclinical diagnosis of COVID-19. url: https://doi.org/10.1016/j.retram.2020.06.001 doi: 10.1016/j.retram.2020.06.001 id: cord-306351-ka6asw3m author: Alsuliman, Tamim title: A review of potential treatments to date in COVID-19 patients according to the stage of the disease date: 2020-05-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Introduction and motivation: Since the end of 2019, the COVID-19 pandemic has affected millions of people worldwide. With the rapid spread of this virus, an immense burden has fallen upon both healthcare and economic systems. As a consequence, there is an unprecedented urgency for researchers and scientific committees from all over the world to find an effective treatment and vaccine. Review Structure: Many potential therapies are currently under investigation, with some, like Hydroxychloroquine, being authorized for emergency use in some countries. The crucial issue is now clearly to find the suitable treatment strategy for patients given comorbidities and the timeline of the illness.Vaccines are also under development and phase 1 clinical trials are rolling. Despite all efforts, no single drug or vaccine has yet been approved. In this review, we aim at presenting the proposed pathophysiological mechanisms of SARS-CoV-2 and to provide clinicians with a brief and solid overview of the current potential treatments classified according to their use at the three different currently proposed disease stages. In light of pathogenesis and proposed clinical classification, this review’s purpose is to summarize and simplify the most important updates on the management and the potential treatment of this emergent disease. url: https://doi.org/10.1016/j.retram.2020.05.004 doi: 10.1016/j.retram.2020.05.004 id: cord-273283-gb0m6fue author: Altschul, David J. title: A novel severity score to predict inpatient mortality in COVID-19 patients date: 2020-10-07 words: 3372.0 sentences: 169.0 pages: flesch: 49.0 cache: ./cache/cord-273283-gb0m6fue.txt txt: ./txt/cord-273283-gb0m6fue.txt summary: While the SOFA score is also predictive of mortality for COVID-19, it does not address the additional thrombotic mitigators of severe illness 11 www.nature.com/scientificreports/ development of disseminated intravascular coagulation (DIC), and now being used to help guide the use of anticoagulation for patients with COVID-19 [12] [13] [14] . This study is an observational cohort study validating a novel, simple COVID-19 in-hospital mortality score to predict inpatient mortality risk in 4711 patients with confirmed SARS-CoV-2 infection using a combination of presentation vital signs, and basic admission laboratory values. A ROC curve analysis was performed in the derivation cohort (Fig. 1) , the novel COVID-19 severity score achieved an AUC of 0.824 (95% CI 0.814-0.851) indicating a good discrimination for patients with higher risk www.nature.com/scientificreports/ www.nature.com/scientificreports/ of in-hospital mortality. abstract: COVID-19 is commonly mild and self-limiting, but in a considerable portion of patients the disease is severe and fatal. Determining which patients are at high risk of severe illness or mortality is essential for appropriate clinical decision making. We propose a novel severity score specifically for COVID-19 to help predict disease severity and mortality. 4711 patients with confirmed SARS-CoV-2 infection were included. We derived a risk model using the first half of the cohort (n = 2355 patients) by logistic regression and bootstrapping methods. The discriminative power of the risk model was assessed by calculating the area under the receiver operating characteristic curves (AUC). The severity score was validated in a second half of 2356 patients. Mortality incidence was 26.4% in the derivation cohort and 22.4% in the validation cohort. A COVID-19 severity score ranging from 0 to 10, consisting of age, oxygen saturation, mean arterial pressure, blood urea nitrogen, C-Reactive protein, and the international normalized ratio was developed. A ROC curve analysis was performed in the derivation cohort achieved an AUC of 0.824 (95% CI 0.814–0.851) and an AUC of 0.798 (95% CI 0.789–0.818) in the validation cohort. Furthermore, based on the risk categorization the probability of mortality was 11.8%, 39% and 78% for patient with low (0–3), moderate (4–6) and high (7–10) COVID-19 severity score. This developed and validated novel COVID-19 severity score will aid physicians in predicting mortality during surge periods. url: https://www.ncbi.nlm.nih.gov/pubmed/33028914/ doi: 10.1038/s41598-020-73962-9 id: cord-289553-gygvhzcc author: Alvarez, Roger A. title: Home Nitric Oxide Therapy for COVID-19 date: 2020-07-01 words: 1825.0 sentences: 89.0 pages: flesch: 43.0 cache: ./cache/cord-289553-gygvhzcc.txt txt: ./txt/cord-289553-gygvhzcc.txt summary: 130-132) present an interesting and compelling case of a patient with pulmonary arterial hypertension (PAH) who was treated remotely in an ambulatory setting with inhaled nitric oxide (iNO) (5) . In a randomized and placebo-controlled trial of ambulatory patients with fibrotic lung disease requiring long-term oxygen, INOpulse therapy was associated with greater physical activity than placebo, and in an acute dose escalation study of patients with pulmonary hypertension associated with pulmonary fibrosis, iNO delivered through the INOpulse system lead to a 30% reduction in pulmonary vascular resistance, with improvements in Q _ and pulmonary artery compliance (15) . The Hestia criteria identified a cohort of patients with acute PE who completed outpatient therapy with a low risk of adverse events, including recurrent venous thromboembolism (2%), all-cause mortality (1%), and major bleeding (0.7%). abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32437250/ doi: 10.1164/rccm.202005-1906ed id: cord-255831-nrc35tug author: Alviggi, Carlo title: COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management date: 2020-05-13 words: 4469.0 sentences: 243.0 pages: flesch: 45.0 cache: ./cache/cord-255831-nrc35tug.txt txt: ./txt/cord-255831-nrc35tug.txt summary: The prolonged lockdown of health services providing high-complexity fertility treatments –as currently recommended by many reproductive medicine entities– is detrimental for society as a whole, and infertility patients in particular. Along these lines, the ART calculator -a clinical predictive model used to estimate the number of mature (metaphase II) oocytes needed to obtain at least one euploid embryo in couples undergoing ARTindicates that 13 (95% confidence interval [CI]: 11-16), 16 (95% CI: [13] [14] [15] [16] [17] [18] [19] [20] , and 19 (95% CI: [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] oocytes are needed for women aged 38, 39, and 40 years, respectively [10, 11] . Based on female age, ovarian reserve, and previous history of ovarian stimulation -if available-, ''low prognosis'' patients were stratified into four specific subgroups, each of which with a distinct prognosis concerning the likelihood of conceiving and delivering a baby with the use of ART (Supplementary Figure 3) . abstract: The prolonged lockdown of health services providing high-complexity fertility treatments –as currently recommended by many reproductive medicine entities– is detrimental for society as a whole, and infertility patients in particular. Globally, approximately 0.3% of all infants born every year are conceived using assisted reproductive technology (ART) treatments. By contrast, the total number of COVID-19 deaths reported so far represents approximately 1.0% of the total deaths expected to occur worldwide over the first three months of the current year. It seems, therefore, that the number of infants expected to be conceived and born –but who will not be so due to the lockdown of infertility services– might be as significant as the total number of deaths attributed to the COVID-19 pandemic. We herein propose remedies that include a prognostic-stratification of more vulnerable infertility cases in order to plan a progressive restart of worldwide fertility treatments. At a time when preventing complications and limiting burdens for national health systems represent relevant issues, our viewpoint might help competent authorities and health care providers to identify patients who should be prioritized for the continuation of fertility care in a safe environment. url: https://doi.org/10.1186/s12958-020-00605-z doi: 10.1186/s12958-020-00605-z id: cord-311074-j3fw4dfc author: Alviset, Sophie title: Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study date: 2020-10-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Because of the COVID-19 pandemic, intensive care units (ICU) can be overwhelmed by the number of hypoxemic patients. MATERIAL AND METHODS: This single centre retrospective observational cohort study took place in a French hospital where the number of patients exceeded the ICU capacity despite an increase from 18 to 32 beds. Because of this, 59 (37%) of the 159 patients requiring ICU care were referred to other hospitals. From 27th March to 23rd April, consecutive patients who had respiratory failure or were unable to maintain an SpO2 > 90%, despite receiving 10–15 l/min of oxygen with a non-rebreather mask, were treated by continuous positive airway pressure (CPAP) unless the ICU physician judged that immediate intubation was indicated. We describe the characteristics, clinical course, and outcomes of these patients. The main outcome under study was CPAP discontinuation. RESULTS: CPAP was initiated in 49 patients and performed out of ICU in 41 (84%). Median age was 65 years (IQR = 54–71) and 36 (73%) were men. Median respiratory rate before CPAP was 36 (30–40) and median SpO2 was 92% (90–95) under 10 to 15 L/min oxygen flow. Median duration of CPAP was 3 days (IQR = 1–5). Reasons for discontinuation of CPAP were: intubation in 25 (51%), improvement in 16 (33%), poor tolerance in 6 (12%) and death in 2 (4%) patients. A decision not to intubate had been taken for 8 patients, including the 2 who died while on CPAP. Two patients underwent less than one hour CPAP for poor tolerance. In the end, 15 (38%) out of 39 evaluable patients recovered with only CPAP whereas 24 (62%) were intubated. CONCLUSIONS: CPAP is feasible in a non-ICU environment in the context of massive influx of patients. In our cohort up to 1/3 of the patients presenting with acute respiratory failure recovered without intubation. url: https://www.ncbi.nlm.nih.gov/pubmed/33052968/ doi: 10.1371/journal.pone.0240645 id: cord-276267-77903fld author: Al‐Ani, Aysha H. title: Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient date: 2020-05-26 words: 5481.0 sentences: 355.0 pages: flesch: 42.0 cache: ./cache/cord-276267-77903fld.txt txt: ./txt/cord-276267-77903fld.txt summary: 6 Consequently, there is a concern that IBD patients are at greater risk of developing COVID-19 and at increased risk of progressing to a more severe clinical course or even death compared to the general population. 18 Furthermore, there is a recent case report of a possible SARS-CoV-2 gastrointestinal infection causing acute haemorrhagic colitis and signalling COVID-19 disease. Clinical assessment of risk factors for infection in inflammatory bowel disease patients Protection of 318 inflammatory bowel disease patients from the outbreak and rapid spread of COVID-19 infection in Wuhan Risk of infection with methotrexate therapy in inflammatory diseases: a systematic review and meta-analysis Comparative risk of serious infections with biologic and/or immunosuppressive therapy in patients with inflammatory bowel diseases: a systematic review and meta-analysis Infection-related hospitalizations are associated with increased mortality in patients with inflammatory bowel diseases Respiratory tract infections in patients with inflammatory bowel disease: safety analyses from vedolizumab clinical trials abstract: BACKGROUND: The current COVID‐19 pandemic, caused by SARS‐CoV‐2, has emerged as a public health emergency. All nations are seriously challenged as the virus spreads rapidly across the globe with no regard for borders. The primary management of IBD involves treating uncontrolled inflammation with most patients requiring immune‐based therapies. However, these therapies may weaken the immune system and potentially place IBD patients at increased risk of infections and infectious complications including those from COVID‐19. AIM: To summarise the scale of the COVID‐19 pandemic, review unique concerns regarding IBD management and infection risk during the pandemic and assess COVID‐19 management options and drug interactions in the IBD population. METHODS: A literature review on IBD, SARS‐CoV‐2 and COVID‐19 was undertaken and relevant literature was summarised and critically examined. RESULTS: IBD patients do not appear to be more susceptible to SARS‐CoV‐2 infection and there is no evidence of an association between IBD therapies and increased risk of COVID‐19. IBD medication adherence should be encouraged to prevent disease flare but where possible high‐dose systemic corticosteroids should be avoided. Patients should exercise social distancing, optimise co‐morbidities and be up to date with influenza and pneumococcal vaccines. If a patient develops COVID‐19, immune suppressing medications should be withheld until infection resolution and if trial medications for COVID‐19 are being considered, potential drug interactions should be checked. CONCLUSION: IBD patient management presents a challenge in the current COVID‐19 pandemic. The primary focus should remain on keeping bowel inflammation controlled and encouraging medication adherence. url: https://www.ncbi.nlm.nih.gov/pubmed/32348598/ doi: 10.1111/apt.15779 id: cord-269503-ij4u980v author: Amaratunga, Eluwana A title: Bradycardia in Patients With COVID-19: A Calm Before the Storm? date: 2020-06-13 words: 3493.0 sentences: 208.0 pages: flesch: 44.0 cache: ./cache/cord-269503-ij4u980v.txt txt: ./txt/cord-269503-ij4u980v.txt summary: This is a retrospective case series of four patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to St. Luke''s University Health Network ICU between 24 March 2020 and 5 April 2020. A study involving 138 patients infected with COVID-19 in Wuhan, China, demonstrated cardiogenic shock, arrhythmia, and acute cardiac injury to be among common complications; 8.7%, 16.7%, 7.2% respectively [1] . Patient demographics, comorbidities, presenting day of illness since symptom onset, admission heart rate, duration of illness at intubation, duration of illness at onset of bradycardia, vital signs [blood pressure, mean arterial pressure (MAP), oxygen saturation, respiratory rate, temperature], laboratory studies (including cTnI, ferritin, C-reactive protein, D-dimer, fibrinogen), as well as medications and dose adjustments were investigated and compared against episodes of bradycardia. As previously described, acute myocardial injury was thought to be the most common cardiac manifestation in COVID-19 patients and potential for developing cardiac arrhythmias has been noted in a few studies. abstract: Cardiac manifestations of coronavirus disease 19 (COVID-19), including arrhythmia, have been described in the literature. However, to our knowledge, association of COVID-19 with bradycardia has not been reported. This case study describes sinus bradycardia as a potential manifestation of COVID-19. This is a retrospective case series of four patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to St. Luke’s University Health Network ICU between 24 March 2020 and 5 April 2020. Medical records of these patients were reviewed using the EPIC electronic health record system. Demographic, clinical, laboratory, and treatment data were reviewed against periods of bradycardia in each patient. The patient group comprised two males and two females. Two patients had pre-existing cardiovascular (CV) comorbidities but no history of arrythmias. Heart rates ranged between 66 and 88 beats/min on admission. The lowest rates during bradycardia were between 42 and 49 beats/min. The onset of sinus bradycardia in patients 1, 2, and 3 were day nine, 15, and five of illness, respectively. Patient 4 had three episodes of bradycardia, starting on day 10 of illness. Patients’ bradycardia episodes lasted one to 14 days. During bradycardia, maximum body temperatures ranged between 99.9 and 100.2 degree Fahrenheit. Patients 2, 3, and 4 required vasopressors to maintain mean arterial pressure > 65 mmHg during episodes. All four patients were on propofol at some point during bradycardia with patients 1, 2, and 3 also receiving dexmedetomidine. There was no consistent correlation of these medications with bradycardia. Electrocardiogram (ECG) findings included sinus bradycardia. Prolonged QTc interval observed in patient 2 on admission improved during bradycardia. Transient sinus bradycardia is a possible manifestation of COVID-19 and is important for close CV surveillance. Etiology can be multifactorial, but severe hypoxia, inflammatory damage of cardiac pacemaker cells, and exaggerated response to medications are possible triggers. High levels of pro-inflammatory cytokines may act directly on the sinoatrial (SA) node contributing to the development of bradycardia. This may be a warning sign of the onset of a serious cytokine storm. An increased awareness of possible exaggerated bradycardia response is important to consider with the use of empiric medications which have arrhythmogenic effects. url: https://www.ncbi.nlm.nih.gov/pubmed/32550090/ doi: 10.7759/cureus.8599 id: cord-355431-efwuy8p9 author: Ambrosio, Luca title: The role of the orthopaedic surgeon in the COVID-19 era: cautions and perspectives date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The current coronavirus disease 2019 (COVID-19) pandemic has revolutionized global healthcare in an unprecedented way and with unimaginable repercussions. Resource reallocation, socioeconomic confinement and reorganization of production activities are current challenges being faced both at the national and international levels, in a frame of uncertainty and fear. Hospitals have been restructured to provide the best care to COVID-19 patients while adopting preventive strategies not to spread the infection among healthcare providers and patients affected by other diseases. As a consequence, the concept of urgency and indications for elective treatments have been profoundly reshaped. In addition, several providers have been recruited in COVID-19 departments despite their original occupation, resulting in a profound rearrangement of both inpatient and outpatient care. Orthopaedic daily practice has been significantly affected by the pandemic. Surgical indications have been reformulated, with elective cases being promptly postponed and urgent interventions requiring exceptional attention, especially in suspected or COVID-19(+) patients. This has made a strong impact on inpatient management, with the need of a dedicated staff, patient isolation and restrictive visiting hour policies. On the other hand, outpatient visits have been limited to reduce contacts between patients and the hospital personnel, with considerable consequences on post-operative quality of care and the human side of medical practice. In this review, we aim to analyze the effect of the COVID-19 pandemic on the orthopaedic practice. Particular attention will be dedicated to opportune surgical indication, perioperative care and safe management of both inpatients and outpatients, also considering repercussions of the pandemic on resident education and ethical implications. url: https://doi.org/10.1186/s40634-020-00255-5 doi: 10.1186/s40634-020-00255-5 id: cord-350131-rsrlri8m author: Amer, Mohamed A. title: Early recovery patterns of olfactory disorders in COVID-19 patients; a clinical cohort study date: 2020-09-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: A rapidly evolving evidence suggests that smell dysfunction is a common symptom in COVID-19 infection with paucity of data on its duration and recovery rate. OBJECTIVES: Delineate the different patterns of olfactory disorders recovery in patients with COVID-19. METHODS: This cross-sectional cohort study included 96 patients with olfactory complaint confirmed to be COVID-19 positive with recent onset of anosmia. All patients were inquired for smell recovery patterns using self-assessment questionnaires. RESULTS: Ninety six patients completed the study with mean age 34.26 ± 11.91 years. Most patients had sudden anosmia 83%. Loss of smell was accompanied by nonspecific inflammatory symptoms as low-grade fever (17%) and generalized body ache (25%). Nasal symptoms were reported by 33% of patients. Some patients reported comorbidities as D.M (16%), hypertension (8%) or associated allergic rhinitis (25%), different patterns of olfactory recovery showed 32 patients experiencing full recovery (33.3%) while, 40 patients showed partial recovery (41.7%) after a mean of 11 days while 24 patients (25%) showed no recovery within one month from onset of anosmia. CONCLUSION: The sudden olfactory dysfunction is a common symptom in patients with COVID-19. Hyposmia patients recover more rapidly than anosmic ones while the middle age group carried the best prognosis in olfactory recovery. Females possess better potentiality in regaining smell after recovery and the association of comorbidities worsen the recovery rate of olfactory dysfunction in patients with COVID19. LEVEL OF EVIDENCE: Level 2b a cross-sectional cohort study. url: https://api.elsevier.com/content/article/pii/S0196070920304191 doi: 10.1016/j.amjoto.2020.102725 id: cord-315569-e56c5g8h author: Aminian, Ali title: Bariatric Surgical Practice During the Initial Phase of COVID-19 Outbreak date: 2020-04-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There is no data on patients with severe obesity who developed coronavirus disease 2019 (COVID-19) after bariatric surgery. Four gastric bypass operations, performed in a 2-week period between Feb 24 and March 4, 2020, in Tehran, Iran, were complicated with COVID-19. The mean age and body mass index were 46 ± 12 years and 49 ± 3 kg/m(2). Patients developed their symptoms (fever, cough, dyspnea, and fatigue) 1, 2, 4, and 14 days after surgery. One patient had unnoticed anosmia 2 days before surgery. Three patients were readmitted in hospital. All 4 patients were treated with hydroxychloroquine. In two patients who required admission in intensive care unit, other off-label therapies including antiretroviral and immunosuppressive agents were also administered. All patients survived. In conclusion, COVID-19 can complicate the postoperative course of patients after bariatric surgery. Correct diagnosis and management in the postoperative setting would be challenging. Timing of infection after surgery in our series would raise the possibility of hospital transmission of COVID-19: from asymptomatic patients at the time of bariatric surgery to the healthcare workers versus acquiring the COVID-19 infection by non-infected patients in the perioperative period. url: https://www.ncbi.nlm.nih.gov/pubmed/32314249/ doi: 10.1007/s11695-020-04617-x id: cord-287102-o19uwryp author: Amit, Moran title: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study date: 2020-07-18 words: 4182.0 sentences: 204.0 pages: flesch: 52.0 cache: ./cache/cord-287102-o19uwryp.txt txt: ./txt/cord-287102-o19uwryp.txt summary: The factors associated with outcomes of critically ill patients with coronavirus disease 2019 (Covid-19) who required treatment in an intensive care unit (ICU) are yet to be determined. The recorded data included the following: age, sex, medical comorbidities (i.e., smoking status, hypertension, diabetes, ischemic heart disease, chronic heart failure, cancer, chronic kidney disease, immunosuppression, cirrhosis, and dementia), medication history, vital signs, chest X-rays, laboratory studies on admission to the ICU, anti-Covid-19 pharmacological therapy in the ICU (antimalarials, antivirals, anti-inflammatories, and plasma from recovered patients), respiratory support method (invasive or noninvasive mechanical ventilation and oxygen mask), renal replacement therapy, nutrition methods (enteral and total parenteral nutrition), the use of extracorporeal membrane oxygenation (ECMO), complications, and outcome. In this nation-based registry study of critically ill patients with Covid-19 who were admitted to ICUs in Israel, the majority of patients were 55 years and older men, and a large proportion required mechanical ventilation. abstract: Knowledge of the outcomes of critically ill patients is crucial for health and government officials who are planning how to address local outbreaks. The factors associated with outcomes of critically ill patients with coronavirus disease 2019 (Covid-19) who required treatment in an intensive care unit (ICU) are yet to be determined. Methods: This was a retrospective registry-based case series of patients with laboratory-confirmed SARS-CoV-2 who were referred for ICU admission and treated in the ICUs of the 13 participating centers in Israel between 5 March and 27 April 2020. Demographic and clinical data including clinical management were collected and subjected to a multivariable analysis; primary outcome was mortality. Results: This study included 156 patients (median age = 72 years (range = 22–97 years)); 69% (108 of 156) were male. Eighty-nine percent (139 of 156) of patients had at least one comorbidity. One hundred three patients (66%) required invasive mechanical ventilation. As of 8 May 2020, the median length of stay in the ICU was 10 days (range = 0–37 days). The overall mortality rate was 56%; a multivariable regression model revealed that increasing age (OR = 1.08 for each year of age, 95%CI = 1.03–1.13), the presence of sepsis (OR = 1.08 for each year of age, 95%CI = 1.03–1.13), and a shorter ICU stay(OR = 0.90 for each day, 95% CI = 0.84–0.96) were independent prognostic factors. Conclusions: In our case series, we found lower mortality rates than those in exhausted health systems. The results of our multivariable model suggest that further evaluation is needed of antiviral and antibacterial agents in the treatment of sepsis and secondary infection. url: https://www.ncbi.nlm.nih.gov/pubmed/32708357/ doi: 10.3390/jcm9072282 id: cord-277148-xzpuc22p author: Ammirati, Enrico title: UPDATE ON ACUTE MYOCARDITIS date: 2020-06-01 words: 5852.0 sentences: 280.0 pages: flesch: 37.0 cache: ./cache/cord-277148-xzpuc22p.txt txt: ./txt/cord-277148-xzpuc22p.txt summary: Acute myocarditis (AM), a recent-onset inflammation of the heart, has heterogeneous clinical presentations, varying from minor symptoms to high-risk cardiac conditions with severe heart failure, refractory arrhythmias, and cardiogenic shock. In the last decade, the measurement of high-sensitive (hs) troponin levels for identifying myocardial injury and the use of cardiac magnetic resonance imaging (CMRI) for characterizing myocardial tissue changes, allowed to diagnose AM non-invasively and with reasonable accuracy, in a wider population of patients including low-risk subjects. Attention will be paid to contemporary outcomes and predictors of prognosis, the emerging entity of immune checkpoint inhibitors (ICI)-associated myocarditis, updated CMRI diagnostic criteria, new data on the use of temporary mechanical circulatory supports (MCS) in FM. Thus, simple factors such as clinical presentation, wide QRS, and reduced LVEF on admission can help identifying high-risk patients, in whom EMB is recommended to guide subsequent therapeutic strategies (e.g. search for specific etiologies or associated conditions, immunosuppressive regimen, short-term temporary MCS, and screening for HTx listing). abstract: Acute myocarditis (AM), a recent-onset inflammation of the heart, has heterogeneous clinical presentations, varying from minor symptoms to high-risk cardiac conditions with severe heart failure, refractory arrhythmias, and cardiogenic shock. AM is moving from being a definitive diagnosis based on histological evidence of inflammatory infiltrates on cardiac tissue to a working diagnosis supported by high sensitivity troponin increase in association with specific cardiac magnetic resonance imaging (CMRI) findings. Though experts still diverge between those advocating for histological definition versus those supporting a mainly clinical definition of myocarditis, in the real-world practice the diagnosis of AM has undoubtedly shifted from being mainly biopsy-based to solely CMRI-based in most of clinical scenarios. It is thus important to clearly define selected settings where EMB is a must, as information derived from histology is essential for an optimal management. As in other medical conditions, a risk-based approach should be promoted in order to identify the most severe AM cases requiring appropriate bundles of care, including early recognition, transfer to tertiary centers, aggressive circulatory supports with inotropes and mechanical devices, histologic confirmation and eventual immunosuppressive therapy. Despite improvements in recognition and treatment of AM, including a broader use of promising mechanical circulatory supports, severe forms of AM are still burdened by dismal outcomes. This review is focused on recent clinical studies and registries that shed new insights on AM. Attention will be paid to contemporary outcomes and predictors of prognosis, the emerging entity of immune checkpoint inhibitors-associated myocarditis, updated CMRI diagnostic criteria, new data on the use of temporary mechanical circulatory supports in fulminant myocarditis. The role of viruses as etiologic agents will be reviewed and a brief update on pediatric AM is also provided. Finally, we summarize a risk-based approach to AM, based on available evidence and clinical experience. url: https://api.elsevier.com/content/article/pii/S1050173820300797 doi: 10.1016/j.tcm.2020.05.008 id: cord-356246-4p0ok1mc author: Ammirati, Enrico title: Heart-Kidney Transplanted patient affected by COVID-19 pneumonia treated with tocilizumab on top of immunosuppressive maintenance therapy date: 2020-07-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.ijcha.2020.100596 doi: 10.1016/j.ijcha.2020.100596 id: cord-306595-ru725fbr author: Ammor, Othmane title: Hidroxicloroquina / cloroquina y azitromicina en pacientes con COVID-19: estudio prospectivo de parámetros eléctricos date: 2020-09-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2605153220301072 doi: 10.1016/j.rccl.2020.09.002 id: cord-296936-5gkx4jxa author: An, M. H. title: Treatment Response to Hydroxychloroquine and Antibiotics for mild to moderate COVID-19: a retrospective cohort study from South Korea date: 2020-07-07 words: 3788.0 sentences: 218.0 pages: flesch: 49.0 cache: ./cache/cord-296936-5gkx4jxa.txt txt: ./txt/cord-296936-5gkx4jxa.txt summary: Results: Kaplan-Meier curves drawn using propensity score-matched data revealed no differences between the length of time to viral clearance and duration of hospital stay between the two treatment arms (p=0.18, p=0.088). Conclusions: HQ with antibiotics was not associated with better clinical outcomes in terms of time to viral clearance, length of hospital stay, and duration of symptoms compared to conservative treatment alone. There were significant differences between two groups before propensity score matching in all endpoints: time to viral clearance, hospital stay, and symptom duration ( Table 2) . This retrospective cohort study compared treatment response to two different treatment protocols in mild to moderate COVID-19 patients using several clinical outcome measures. HQ with antibiotics was not associated with better clinical outcomes and did not reduce time to viral clearance, length of hospital stays, and duration of symptoms compared to conservative treatment in mild to moderate COVID-19 patients. abstract: Objectives: To assess the efficacy of hydroxychloroquine on mild-moderate COVID-19 patients in South Korea. Methods: A retrospective cohort study of the 358 laboratory-confirmed SARS-CoV-2 (COVID-19) patients was conducted. 226 patients met inclusion criteria for analysis. Propensity score matching (PSM) and Cox regression method were utilized to control and adjust for confounding factors. Mild to moderate COVID-19 patients were managed with hydroxychloroquine (HQ) plus antibiotics (n = 31) or conservative treatment (n = 195). Results: Kaplan-Meier curves drawn using propensity score-matched data revealed no differences between the length of time to viral clearance and duration of hospital stay between the two treatment arms (p=0.18, p=0.088). Multivariable Cox regression analysis similarly showed that time to viral clearance(Hazard ratio (HR) 0.97, [95%-confidence interval (CI): 0.57-1.67]) and symptom duration(HR 1.05, [95%-CI: 0.62-1.78]) were not different between groups. No severe adverse event or death was observed in either group. Conclusions: HQ with antibiotics was not associated with better clinical outcomes in terms of time to viral clearance, length of hospital stay, and duration of symptoms compared to conservative treatment alone. Large prospective randomized trials are necessary for definitive conclusions. url: http://medrxiv.org/cgi/content/short/2020.07.04.20146548v1?rss=1 doi: 10.1101/2020.07.04.20146548 id: cord-289574-engwi8h3 author: An, Peng-jiao title: Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications date: 2020-05-23 words: 3188.0 sentences: 220.0 pages: flesch: 39.0 cache: ./cache/cord-289574-engwi8h3.txt txt: ./txt/cord-289574-engwi8h3.txt summary: Accumulating evidence suggested that the progression of COVID-19 is associated with lymphopenia and excessive inflammation, and a subset of severe cases might exhibit cytokine storm triggered by secondary hemophagocytic lymphohistiocytosis (sHLH). Previously, it has been found that the serum levels of pro-inflammatory cytokines [IFN-γ, IL-1, IL-6, IL-12, and transforming growth factor-β (TGF-β)], and chemokines (CCL2, CXCL9, CXCL10, and IL-8) in SARS-CoV infected patients were higher than those in healthy individuals. Procalcitonin (PCT), released by bacterial infectious tissues under the irritation of pro-inflammatory cytokines, is a more specific marker of serious bacterial infection compared to C-reactive protein (CRP) and IL-6 [111] PCT-based strategy has been applied to guide antibiotic use in ICU or emergency wards, since the serum PCT levels in patients with severe bacterial infections are much higher than those with simple viral infections or non-specific inflammatory diseases [111] [112] [113] . The definition and risks of Cytokine Release Syndrome-Like in 11 COVID-19-Infected Pneumonia critically ill patients: Disease Characteristics and Retrospective Analysis abstract: Coronavirus Disease 2019 (COVID-19) has sparked a global pandemic, affecting more than 4 million people worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute lung injury (ALI) and even acute respiratory distress syndrome (ARDS); with a fatality of 7.0 %. Accumulating evidence suggested that the progression of COVID-19 is associated with lymphopenia and excessive inflammation, and a subset of severe cases might exhibit cytokine storm triggered by secondary hemophagocytic lymphohistiocytosis (sHLH). Furthermore, secondary bacterial infection may contribute to the exacerbation of COVID-19. We recommend using both IL-10 and IL-6 as the indicators of cytokine storm, and monitoring the elevation of procalcitonin (PCT) as an alert for initiating antibacterial agents. Understanding the dynamic progression of SARS-CoV-2 infection is crucial to determine an effective treatment strategy to reduce the rising mortality of this global pandemic. url: https://api.elsevier.com/content/article/pii/S1043661820312548 doi: 10.1016/j.phrs.2020.104946 id: cord-310823-xksu8fn1 author: Anand, Abhinav title: Obesity and mortality in COVID-19: cause or association? date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0016508520351544?v=s5 doi: 10.1053/j.gastro.2020.08.055 id: cord-258888-amimzjee author: Ananth, Lakshmi title: Management of ENT Surgical Emergencies Amidst COVID-19 Lockdown: Our Experience in a Tertiary Referral Hospital date: 2020-07-23 words: 3667.0 sentences: 187.0 pages: flesch: 48.0 cache: ./cache/cord-258888-amimzjee.txt txt: ./txt/cord-258888-amimzjee.txt summary: Appropriate protocols for screening, triage and management of non-COVID patients with due precautions and infection control strategies can ensure that emergencies get timely and appropriate attention while preventing spread of infection among patients and healthcare workers. In this article, we describe our experience with the triage and management of ENT & Lakshmi Ananth lakshmiananth@yahoo.com emergencies at a tertiary referral hospital in the setting of a lockdown with limited resources and the protocol followed by us to maximize the safety of health care personnel involved and avoiding the possibility of hospital transmission of infection. In the absence of testing facility, the above suggested protocol will be helpful while performing surgeries even after the lockdown period ends in order to minimize the risk of hospital transmission of infection and increase the safety of patients and healthcare workers. abstract: To describe our experience with ENT emergencies during lockdown due to COVID-19 pandemic and provide recommendations for triage, management and protective measures. Retrospective case series. Eleven patients requiring emergency ENT procedures in a tertiary referral hospital during the lockdown period of 24th March to 3rd May 2020 were identified. Clinical profiles, screening and operating room protocols along with the post-operative care and use of personal protective equipment are described. Nine patients were discharged from the hospital and two were in stable condition in the hospital. While lockdowns may be effective in controlling the transmission of COVID-19, they have a negative impact on the routine functioning of healthcare services. Appropriate protocols for screening, triage and management of non-COVID patients with due precautions and infection control strategies can ensure that emergencies get timely and appropriate attention while preventing spread of infection among patients and healthcare workers. url: https://doi.org/10.1007/s12070-020-01987-7 doi: 10.1007/s12070-020-01987-7 id: cord-016208-u12ngkpc author: Andersen, Bjørg Marit title: Intensive Patient Treatment date: 2018-09-25 words: 4579.0 sentences: 334.0 pages: flesch: 50.0 cache: ./cache/cord-016208-u12ngkpc.txt txt: ./txt/cord-016208-u12ngkpc.txt summary: Intensive care units (ICUs) are treating hospital''s poorest patients that need medical assistance during the most extreme period of their life. Intensive patients are treated with extensive invasive procedures, which may cause a risk of hospital infections in 10–30% of the cases. The hospital''s management should provide resources and written guidelines regarding infection control work, proper patient/care ratio, sufficient patient areas, isolation capacity and documented competence. Intensive care unit (ICU) should have a large enough area and furnished for a good, safe and effective infection protection [1] . Recent studies indicate that patients in separate ICU rooms will have fewer hospital infections and thus a lower risk of fatal outcome [72, 73] . An outbreak of multidrug-resistant Pseudomonas aeruginosa associated with increased risk of patient death in an intensive care unit Single rooms may help to prevent nosocomial blood stream infection and cross-transmission of methicillin-resistant Staphylococcus aureus in intensive care units abstract: Intensive care units (ICUs) are treating hospital’s poorest patients that need medical assistance during the most extreme period of their life. Intensive patients are treated with extensive invasive procedures, which may cause a risk of hospital infections in 10–30% of the cases. More than half of these infections can be prevented. The patients are often admitted directly from outside the hospital or from abroad with trauma after accidents, serious heart and lung conditions, sepsis and other life-threatening diseases. Infection or carrier state of microbes is often unknown on arrival and poses a risk of transmission to other patients, personnel and the environment. Patients that are transferred between different healthcare levels and institutions with unknown infection may be a particular risk for other patients. In spite of the serious state of the patients, many ICUs have few resources and are overcrowded and understaffed, with a lack of competent personnel. ICU should have a large enough area and be designed, furnished and staffed for a good, safe and effective infection control. The following chapter is focused on practical measures to reduce the incidence of infections among ICU patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120427/ doi: 10.1007/978-3-319-99921-0_45 id: cord-017531-fm8gl5b3 author: Andersen, Bjørg Marit title: Scenarios: Serious, Infectious Diseases date: 2018-09-25 words: 3604.0 sentences: 288.0 pages: flesch: 53.0 cache: ./cache/cord-017531-fm8gl5b3.txt txt: ./txt/cord-017531-fm8gl5b3.txt summary: All transport of infectious patients from the place of arrival to the hospital should take place in ambulances using the same infection control regime as for the individual infectious disease (contact infection, airborne infection, strict isolation); see isolation regimes; Chaps. • Ambulance staff and other personnel use the contact and airborne infection regime when picking up and transporting a patient. Short-time airborne isolation of exposed cases until the infection state is clarified/effect of antibacterial therapy 82.5.6 Anthrax After Staying in Turkey, Sick on the Plane Home 82.5.6.1 Patient: Strict Isolation-Air Pressure Isolate with Pressure [21, 22] Example: Two out of six people who have been on family visits in Turkey for a week, on farms with goats and skin production, are acutely ill on the plane home with cough, shortness of breath and fever. Less severe disease: isolation of index case and close contacts • Registering: All exposed persons are registered (name, address, telephone number) and followed up. abstract: Scenarios for serious, infectious diseases are important procedures used to understand the special microbe’s behaviour (clinical illness, spread of infection, etc.) and how to act most rational during special dangerous outbreaks. Furthermore, scenarios describe how to handle patients, personnel and others possibly exposed to infections,- outside and inside the hospital- to stop spread of the infection as soon as possible. Today, it is not acceptable to place a patient with a known high-risk, serious infection in the same hospital room as other patients with not the same disease (WHO). In this chapter, some seldom but realistic scenario is described to better understand how to react and treat patients to stop spread of microbes during the primary phase of dangerous transmittable diseases. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122114/ doi: 10.1007/978-3-319-99921-0_82 id: cord-017534-0ai8chbu author: Andersen, Bjørg Marit title: Background Information: Isolation Routines date: 2018-09-25 words: 9640.0 sentences: 603.0 pages: flesch: 51.0 cache: ./cache/cord-017534-0ai8chbu.txt txt: ./txt/cord-017534-0ai8chbu.txt summary: There is an increased need of isolates for patients with infections, especially due to pulmonary tuberculosis, MRSA, VRE, Clostridium difficile (CD), multiresistant gram-negative bacteria and other "multidrug-resistant organisms" (MDRO) [23, 24, 36, 37, [48] [49] [50] [51] . In 2009, a European investigation was done as regards the number of "high-level isolation rooms" (HIRs), i.e. airborne infection isolation units with negative pressure (not defined) with at least 6 air changes per hour and sluice (anteroom) [61] . CDC defines contact isolation, using gown and gloves when in contact with patients infected with resistant bacteria like MRSA and other MDROs (multidrug-resistant organisms), and single rooms are recommended [19] . Spread of pathogenic infectious agents through the air and droplets requires a defined negative pressure ventilation isolate and a system which reduces airborne infection in the patient''s room. abstract: The isolation of patients with suspected or documented infections—to not spread to others—has been discussed for hundreds of years. Guidelines are many, methods are different, attitudes show vide variations, routines and procedures are still changing, regulations by law may be absent, and some healthcare professionals may be afraid of adverse outcomes of isolation [1–44]. Microbes that are spread in the environment, on the hands and equipment are invisible. The invisible agent does not call on attention before the infection; clinical disease, hospital infection or nosocomial infection is a factum that can be registered [23, 28, 29, 35–37]. How to stop the transmission is often “to believe and not believe” in infection control. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122118/ doi: 10.1007/978-3-319-99921-0_21 id: cord-017815-0t7jvvz5 author: Andersen, Bjørg Marit title: General Information date: 2018-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Many bacteria, viruses, parasites, fungi and prions may cause serious infections and lead to the isolation of those who are infected from those who are susceptible. Isolation may be done in single rooms or in special isolation units. A modern isolate for patients with infections comprises (1) a sluice with a good space for dressing and undressing of personal protective equipment (PPE) and for hand hygiene, (2) a large patient room and (3) a bathroom/disinfection room with own decontaminator or autoclave and with separate entrance from the patient’s room. Isolates for airborne and droplet-transmitted infections have in addition a defined negative air pressure and hepafiltered exhaust. In all isolates, doors must be closed in such a way that contaminants do not escape the isolate. A modern isolate for patients with impaired immune defence is similar to the infection isolates, with following exceptions: usually no need for decontaminator, hepafiltered clean air into the room and with a defined positive air pressure. A positive pressure isolate should never be used for patients with infections, and a negative pressure isolate should never be used for patients with impaired immune defence, except if the patient also has an infection that needs isolation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122486/ doi: 10.1007/978-3-319-99921-0_15 id: cord-316673-ffkh13xm author: Andina, David title: Chilblains in children in the setting of COVID‐19 pandemic date: 2020-05-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Different skin manifestations of COVID‐19 are being reported. Acral lesions on the hands and feet, closely resembling chilblains, have been recognized during the peak incidence of the COVID‐19 pandemic. MATERIAL AND METHODS: A retrospective review of 22 children and adolescents with chilblain‐like lesions seen over a short period of time in the Emergency Department of a children's hospital during the peak incidence of COVID‐19 in Madrid, Spain. RESULTS: All patients had lesions clinically consistent with chilblains of the toes or feet, with three also having lesions of the fingers. Pruritus and mild pain were the only skin symptoms elicited, and only 10 had mild respiratory and/or GI symptoms. None had fever. Coagulation tests, hemogram, serum chemistry, and lupus anticoagulant were normal in all patients tested. One out of 16 tested cases had elevated D‐dimer results, but without systemic symptoms or other laboratory anomalies. SARS‐CoV‐2 PCR tested in 19 cases was positive in just one case. Skin biopsies obtained in six patients were consistent with chilblains. On follow‐up, all cases showed spontaneous marked improvement or complete healing. CONCLUSION: Acute chilblains were observed during COVID‐19 pandemic in children and teenagers. It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. Etiopathogenesis remains unknown. url: https://www.ncbi.nlm.nih.gov/pubmed/32386460/ doi: 10.1111/pde.14215 id: cord-258916-jbdz1pk0 author: Andreae, MH title: Data and Debriefing Observations on Healthcare Simulation to Prepare for the COVID-19 Pandemic: Healthcare Simulation for COVID-19 date: 2020-07-15 words: 2882.0 sentences: 161.0 pages: flesch: 40.0 cache: ./cache/cord-258916-jbdz1pk0.txt txt: ./txt/cord-258916-jbdz1pk0.txt summary: We report on data and debriefing observations in the context of an immersive simulation conducted to (a) train clinicians and (b) test new protocols and kits, developed in table-top exercises without prior clinical experience to fit anticipated clinical encounters in the setting of the rapidly expanding COVID-19 pandemic. We simulated scenarios with particular relevance for anesthesiology, perioperative and critical care, including (1) cardiac arrest, (2) emergency airway management, (3) tele-instruction for remote guidance and supervision, and (4) transporting an intubated patient. • Immersive healthcare simulation employing anticipated clinical encounters may be useful to test COVID-19 [8, 10, 11] and other airborne contagious disease hospital protocols, developed with limited clinical experience, to detect shortcoming before such gaps become apparent in clinical care and threaten patient or provider safety. abstract: We report on data and debriefing observations in the context of an immersive simulation conducted to (a) train clinicians and (b) test new protocols and kits, developed in table-top exercises without prior clinical experience to fit anticipated clinical encounters in the setting of the rapidly expanding COVID-19 pandemic. We simulated scenarios with particular relevance for anesthesiology, perioperative and critical care, including (1) cardiac arrest, (2) emergency airway management, (3) tele-instruction for remote guidance and supervision, and (4) transporting an intubated patient. Using a grounded theory approach, three authors (MHA, DLR, EHS) developed emergent themes. First alone and then together, we sought consensus in uncovering overarching themes and constructs from the debriefings. We thus performed an informal qualitative thematic analysis based in a critical realist epistemological position - the understanding that our findings, while real, are affected by situational variables and the observer's perspective.[1,2] We compared data from videos and triangulated the data by member checking. All participants and course instructors volunteered to participate in this educational project and contributed as co-authors to this manuscript. During debriefing, we applied crisis resource management concepts including situation awareness, prioritization of tasks, and clear communication practices, conducting the debriefing with emphasis on current TeamStepps 2.0 terminology and concepts. [3,4] In addition, we re-evaluated formerly familiar processes, as shortcomings of protocols, kits, and interdisciplinary cooperation became apparent. The data provide detailed observations on how immersive simulation and debriefing among peers mitigated the unfamiliarity of individual clinicians and the organization at large with the demands of an unprecedented healthcare crisis. We also observed and report on the anxiety caused by resource constraints, risk to clinicians in the face of limited personal equipment, and the overall uncertainty surrounding COVID-19. We began to summarize, interpret, critique, and discuss our data and debriefing observations in a rapid co-publication in the Journal of Clinical Anesthesia. [Healthcare Simulation to Prepare for the COVID-19 Pandemic][5] url: https://api.elsevier.com/content/article/pii/S2352340920309227 doi: 10.1016/j.dib.2020.106028 id: cord-031710-1xl2isee author: Andrei, Stefan title: Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia – case report date: 2020-09-10 words: 2582.0 sentences: 137.0 pages: flesch: 40.0 cache: ./cache/cord-031710-1xl2isee.txt txt: ./txt/cord-031710-1xl2isee.txt summary: title: Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia – case report CASE PRESENTATION: We present the rare case of successful outcome in a 61-year-old female who developed alveolar haemorrhage and acute respiratory distress syndrome 8 days after a chemotherapy session for her acute lymphoblastic leukaemia, in the context of secondary bone marrow aplasia. We report the case of successfully treated severe Stenotrophomonas maltophilia respiratory infection complicated with pulmonary haemorrhage in a chemotherapyinduced pancytopenia patient diagnosed with acute lymphoblastic leukaemia. To our knowledge, this is the first reported case of pulmonary haemorrhage and ARDS caused by a fulminant Stenotrophomonas maltophilia respiratory infection in Eastern Europe, and it seems to be a rare case of positive outcome in a patient with haematological malignancy. abstract: BACKGROUND: Stenotrophomonas maltophilia-induced pulmonary haemorrhage is considered a fatal infection among haematological patients. The outcome can be explained by the patients’ immunity status and late diagnosis and treatment. CASE PRESENTATION: We present the rare case of successful outcome in a 61-year-old female who developed alveolar haemorrhage and acute respiratory distress syndrome 8 days after a chemotherapy session for her acute lymphoblastic leukaemia, in the context of secondary bone marrow aplasia. Stenotrophomonas maltophilia was isolated in sputum culture. The patient benefitted from early empirical treatment with colistin followed by trimethoprim/sulfamethoxazole, according to the antibiogram. Despite a severe initial clinical presentation in need of mechanical ventilation, neuromuscular blocking agents infusion, and ventilation in prone position, the patient had a favourable outcome and was discharged from intensive care after 26 days. CONCLUSIONS: Stenotrophomonas maltophilia severe pneumonia complicated with pulmonary haemorrhage is not always fatal in haematological patients. Empirical treatment of multidrug-resistant Stenotrophomonas maltophilia in an immunocompromised haematological patient presenting with hemoptysis should be taken into consideration. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482381/ doi: 10.1186/s12879-020-05378-9 id: cord-287367-1sdt9zz8 author: Andrews, Denise title: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use date: 2017-10-10 words: 6429.0 sentences: 297.0 pages: flesch: 48.0 cache: ./cache/cord-287367-1sdt9zz8.txt txt: ./txt/cord-287367-1sdt9zz8.txt summary: title: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use Consequently, though respiratory viruses are frequently isolated in community acquired pneumonia (CAP) [2] and are reported to be responsible for 12.8% of CAP cases admitted to UK hospitals [3] , the decision to manage as a viral RTI or treat for bacterial infection including Mycoplasma pneumoniae or Chlamydia pneumoniae (''atypical bacteria'') is based upon the clinical scenario and severity criteria such as the CURB-65 score. We undertook a study to assess the FilmArray® RP panel as a POC test compared to routine, laboratory-based detection methods in order to assess the impact on length of stay and antibiotic utilization. The aim of the study was to determine whether in adults presenting with upper respiratory tract infection (URTI)/ influenza-like illness (ILI) +/− lower respiratory tract infection (LRTI), FilmArray® RP panel POC testing, when compared to the routine, laboratory-based RP testing was associated with length of hospital stay or antimicrobial use. abstract: BACKGROUND: Laboratory-based respiratory pathogen (RP) results are often available too late to influence clinical decisions such as hospitalisation or antibiotic treatment due to time delay in transport of specimens and testing schedules. Ward-based i.e. point of care (POC) testing providing rapid results may alter the clinical management pathway. METHODS: FilmArray® RP polymerase chain reaction (PCR) systems were placed in three in-patient and out-patient medical areas. Patients presenting with influenza-like illness /upper respiratory tract infection +/− lower RTI were recruited between January–July 2015. FilmArray® POC testing occurred on even days of the month (intervention) or routine, laboratory-based RP PCR testing +/− atypical serology on odd days (control). The primary outcome was length of hospital stay. The secondary outcomes were impact on the use of antimicrobials, readmissions, all-cause mortality, length of ward stay and turn-around time (TAT) (time to result from admission). RESULTS: Of 606 eligible patients, 545 (89.9%) were included; 211 in the control arm and 334 in the intervention arm. 20% of control arm patients and 24% of intervention arm patients had an RP detected. POC testing was not associated with the primary outcome measure, length of stay, but reduced the TAT from 39.5 h to 19.0 h, p < 0.001. Only the prescribing decision differed between study arms, p < 0.001. When antivirals were given, the intervention was associated with a reduction in the median time to the first dose of 36 h and allowed appropriate treatment of mycoplasma infection. CONCLUSIONS: We found no association between respiratory PCR POC testing and length of stay or most of the secondary outcomes except the antimicrobial prescribing decision. This was probably due to a delay in initiating FilmArray® testing. Despite this, POC testing allowed time-critical antivirals to be given significantly faster, appropriate mycoplasma treatment and results were available considerably faster than routine, laboratory-based testing. Ward-staff of all grades performed POC testing without difficulty suggesting potential use across many divergent healthcare settings. Further studies evaluating the implementation of rapid respiratory PCR POC testing and the effect on length of stay and antimicrobial use are required. TRIAL REGISTRATION: ISRCTN10470967, Retrospectively Registered, 30/6/2015. url: https://doi.org/10.1186/s12879-017-2784-z doi: 10.1186/s12879-017-2784-z id: cord-274779-0emfl1e5 author: Andrews, Jinsy A. title: Amyotrophic lateral sclerosis care and research in the United States during the COVID‐19 pandemic: Challenges and opportunities date: 2020-06-05 words: 1835.0 sentences: 113.0 pages: flesch: 50.0 cache: ./cache/cord-274779-0emfl1e5.txt txt: ./txt/cord-274779-0emfl1e5.txt summary: Coronavirus disease 2019 has created unprecedented challenges for amyotrophic lateral sclerosis (ALS) clinical care and research in the United States. Most of the 133 sites surveyed between April 21, 2020 and May 1, 2020 are affiliated with academic medical centers in the United States, have multidisciplinary care teams, see large numbers of patients, and participate in a variety of ALS research studies, including clinical trials. The most commonly used measure of ALS progression in clinics and in trials, the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R), can be obtained reliably and easily over the phone or by telemedicine. The COVID-19 pandemic has created an unprecedented challenges to ALS clinical care and research. Our combined experiences of clinician-patient interactions during this pandemic will provide us with new paradigms that will likely improve the efficiency of clinical care and availability of research participation. abstract: Coronavirus disease 2019 has created unprecedented challenges for amyotrophic lateral sclerosis (ALS) clinical care and research in the United States. Traditional evaluations for making an ALS diagnosis, measuring progression, and planning interventions rely on in‐person visits that may now be unsafe or impossible. Evidence‐ and experience‐based treatment options, such as multidisciplinary team care, feeding tubes, wheelchairs, home health, and hospice, have become more difficult to obtain and in some places are unavailable. In addition, the pandemic has impacted ALS clinical trials by impairing the ability to obtain measurements for trial eligibility, to monitor safety and efficacy outcomes, and to dispense study drug, as these also often rely on in‐person visits. We review opportunities for overcoming some of these challenges through telemedicine and novel measurements. These can reoptimize ALS care and research in the current setting and during future events that may limit travel and face‐to‐face interactions. url: https://www.ncbi.nlm.nih.gov/pubmed/32445195/ doi: 10.1002/mus.26989 id: cord-004532-flo9139j author: Andrews, Peter title: Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis date: 2004-12-18 words: 9246.0 sentences: 474.0 pages: flesch: 44.0 cache: ./cache/cord-004532-flo9139j.txt txt: ./txt/cord-004532-flo9139j.txt summary: The authors concluded that their findings are important for trial design because of the observed differences in outcome, and proposed the use of standardized ventilator settings for patient enrollment. As indicated by Yu and Singh [46] , "over 300 studies have been published in peer-review journals in the past 8 years dealing with management of ventilator-associated pneumonia (VAP)." However, no consensus exists to date on the best way for identifying patients with true lung infection, for selecting early appropriate antimicrobial therapy, or for avoiding unnecessary use of antibiotics. [52] designed a study in 108 patients with 171 VAPs to assess the impact on the duration of MV and the use of antibiotic treatment of the results of a diagnostic technique: the percentage of infected cells in liquid obtained with BAL, i.e., the value of direct examination. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079835/ doi: 10.1007/s00134-004-2529-5 id: cord-270348-5804ffwx author: Angelino, Andrew F. title: Design and implementation of a regional inpatient psychiatry unit for asymptomatic SARS-CoV-2 positive patients. date: 2020-07-02 words: 5818.0 sentences: 334.0 pages: flesch: 59.0 cache: ./cache/cord-270348-5804ffwx.txt txt: ./txt/cord-270348-5804ffwx.txt summary: To prevent COVID-19 outbreaks in our units, we next decided to require universal nasal swab testing for SARS-CoV-2 for all medically asymptomatic patients being admitted to psychiatric units 3 . Second, we realized that we needed to decide where to care for SARS-CoV-2 positive, medically asymptomatic patients with mental illnesses who required hospitalization-those without symptoms of COVID-19. In light of the above, we concluded it would best serve our patients if we developed an inpatient psychiatric unit capable of accepting SARS-CoV-2 infected patients without COVID-19 symptoms, or with mild enough symptoms that they would not require medical hospitalization. Further, it is highly beneficial for continuity of care if the patient requires transfer to a medical COVID-19 unit that the psychiatrist be able to follow them there and maintain the psychiatric treatments as indicated. abstract: Patients with psychiatric illnesses are particularly vulnerable to highly contagious, droplet spread organisms like SARS-CoV-2. Patients with mental illnesses may not be able to consistently follow behavioral prescriptions to avoid contagion, and they are frequently found in settings with close contact and inadequate infection control, such as group homes, homeless shelters, residential rehabilitation centers, and correctional facilities. Further, inpatient psychiatry settings are generally designed as communal spaces, with heavy emphasis on group and milieu therapies. As such, inpatient psychiatry services are vulnerable to rampant spread of contagion. With this in mind, the authors outline the decision process and ultimate design and implementation of a regional inpatient psychiatry unit for asymptomatic SARS-CoV-2 infected patients, and share key points for consideration in implementing future units elsewhere. A major take-away point of the analysis is the particular expertise of trained experts in psychosomatic medicine for treating SARS-CoV-2 infected patients. url: https://api.elsevier.com/content/article/pii/S0033318220302048 doi: 10.1016/j.psym.2020.06.018 id: cord-347238-yacn6xqk author: Angurala, Mohit title: An Internet of Things Assisted Drone Based Approach to Reduce Rapid Spread of Covid-19 date: 2020-07-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract With the quick spread of pandemic disease, many individuals have lost their lives across different parts of the world. So, the need for a novel approach or model to overcome the problem becomes a necessity. In this paper, a mechanism is proposed called DBCMS (Drone Based Covid-19 Medical Service) for the safety of medical employees who are prone to Covid-19 infection. The proposed mechanism can effectively improve the treatment process of Covid-19 patients. Drones are nowadays commonly used in the field of medical emergency situations. The proposed model in this paper uses drone service to reduce the risk of infection to the doctors or other medical staff, thereby preventing the disease spread. This paper further assumes that the primary step is to isolate people at their home instead of admitting them to the hospitals, also called a situation of lockdown or curfew. Thus, in this way, the spread can be significantly reduced across the globe if DBCMS approach is implemented at cluster level. url: https://www.sciencedirect.com/science/article/pii/S2666449620300116?v=s5 doi: 10.1016/j.jnlssr.2020.06.011 id: cord-024130-kgzegwon author: Ankita title: COVID-19: An Ophthalmological Update date: 2020-04-30 words: 2845.0 sentences: 190.0 pages: flesch: 51.0 cache: ./cache/cord-024130-kgzegwon.txt txt: ./txt/cord-024130-kgzegwon.txt summary: Conjunctival secretions from patients and asymptomatic contacts of COVID-19 cases may also spread the disease further into the community. In view of the presence of coronavirus in body fluids of patients, and SARS-CoV-2 being similar to SARS-CoV, the risk of transmission through conjunctival secretion and tear cannot be neglected. Patients with conjunctivitis may initially report to an ophthalmologist, possibly making the eye care physician to first suspect a case of COVID-19 (Lu et al. According to a recently published literature on COVID-19 conjunctivitis, tear sample and conjunctival swab are reported to be positive for the novel coronavirus. As per recent AAO guidelines, as a response to the state of national emergency due to COVID-19, eye care practitioners should reduce the number of outpatient The following preventive measures should be taken by the ophthalmologist in the outpatient clinic for general patients (Group 1 and 2) during such outbreaks: Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection abstract: Ever since the newscast of the novel coronavirus outbreak in Wuhan and its subsequent spread to several countries worldwide, the possible modes of spread are being anticipated by various health care professionals. Tear and other conjunctival secretions, being one of the body fluids, can potentially help transmit the disease inadvertently. Conjunctival secretions from patients and asymptomatic contacts of COVID-19 cases may also spread the disease further into the community. Direct inoculation of body fluids into the conjunctiva of healthy individual is also postulated to be another mode of spread. The risk to heath care providers thus becomes strikingly high. A vigilant ophthalmologist can play a critical role in breaking the chain of transmission. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189394/ doi: 10.1007/978-981-15-4814-7_8 id: cord-304602-jpxjiaru author: Anneser, Johanna title: Dying patients with COVID-19: What should Hospital Palliative Care Teams (HPCTs) be prepared for? date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: The COVID-19 pandemic is a care crisis of unknown duration which has seemingly not yet reached its peak in many countries. A significant number of elderly and frail people and those with underlying serious illness will continue to develop severe forms of the COVID-19 infection. Most of them are not eligible for intensive care treatment but can still expect palliative care — in many cases provided by a Hospital Palliative Care Team (HPCT). Several teams have already gained experience in caring for these patients and their families, others are preparing for it. METHOD: We report on a COVID-19 patient with pre-existing acute myeloid leukemia who was looked after by a HPCT until death. We discuss the challenges and difficulties while caring for COVID-19-positive palliative patients in a non-ICU setting. RESULTS: Hospitalization of the patient in an isolation ward caused an enormous burden for the dying patient and his family. Symptom control was particularly difficult because of rapid deteriorating dyspnea and the scarce presence of medical staff in the patient's room. SIGNIFICANCE OF RESULTS: COVID-19 patients who are not eligible for ICU treatment may have a particularly high need for palliative care. Since beds in specialist palliative care units are limited, the HPCT should be prepared to care for these patients. They may offer support in decision-making, optimize symptom control, and provide psychosocial care for patients and their families. Visiting restrictions aimed to protect the general public must be weighted against the patient's and family's suffering. url: https://doi.org/10.1017/s1478951520000450 doi: 10.1017/s1478951520000450 id: cord-263883-7ba0huwy author: Ansarin, Khalil title: Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial date: 2020-07-19 words: 3119.0 sentences: 186.0 pages: flesch: 51.0 cache: ./cache/cord-263883-7ba0huwy.txt txt: ./txt/cord-263883-7ba0huwy.txt summary: The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ventilation, and mortality in patients with COVID-19. The current study, an open-label, randomized clinical trial, examined the efficacy of early start of oral bromhexine, in the intensive care unit (ICU) admission, rate of mechanical ventilation, and mortality in patients with COVID-19 pneumonia. The data presented in this clinical trial confirmed that the early-onset treatment with oral bromhexine 8 mg three times a day not only effectively mitigated the respiratory symptoms, but also significantly decreased the rate of ICU admissions, intubation, mechanical ventilation, and mortality in COVID-19 disease. The data analysis of this clinical trial also showed that cardinal respiratory symptoms (cough, lassitude, and dyspnea) in patients with COVID-19 disease who received bromhexine treatment was remarkably less than the standard group. abstract: [Image: see text] Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ventilation, and mortality in patients with COVID-19. Methods: An open-label randomized clinical trial study was performed in Tabriz, North-West of Iran. They were randomized to either the treatment with the bromhexine group or the control group, in a 1:1 ratio with 39 patients in each arm. Standard therapy was used in both groups and those patients in the treatment group received oral bromhexine 8 mg three times a day additionally. The primary outcome was a decrease in the rate of ICU admissions, intubation/mechanical ventilation, and mortality. Results: A total of 78 patients with similar demographic and disease characteristics were enrolled. There was a significant reduction in ICU admissions (2 out of 39 vs. 11 out of 39, P = 0.006), intubation (1 out of 39 vs. 9 out of 39, P = 0.007) and death (0 vs. 5, P = 0.027) in the bromhexine treated group compared to the standard group. No patients were withdrawn from the study because of adverse effects. Conclusion: The early administration of oral bromhexine reduces the ICU transfer, intubation, and the mortality rate in patients with COVID-19. This affordable medication can easily be administered everywhere with a huge positive impact(s) on public health and the world economy. Altogether, the verification of our results on a larger scale and different medical centers is strongly recommended. Trial Registration: IRCT202003117046797N4; https://irct.ir/trial/46969. url: https://www.ncbi.nlm.nih.gov/pubmed/32983936/ doi: 10.34172/bi.2020.27 id: cord-290341-ei768v4s author: Anstey, D. Edmund title: The cardiac intensive care unit and the cardiac Intensivist during the COVID-19 surge in New York City() date: 2020-07-03 words: 4209.0 sentences: 228.0 pages: flesch: 44.0 cache: ./cache/cord-290341-ei768v4s.txt txt: ./txt/cord-290341-ei768v4s.txt summary: Herein we discuss the evolving role of the cardiac intensivist and changes to the CICU in the era of the COVID-19 pandemic and provide recommendations based on our own experiences at NewYork-Presbyterian Columbia University Irving Medical Center. There are several domains across which innovation may occur including the physical layout of the CICU, the timing of laboratory and diagnostic studies, medication administration, clinical monitoring, and the management of cardiac arrests. Timing of Lab Testing and Diagnostic Studies: As typical of critically ill patients, patients in an intensive care setting with COVID-19 will require frequent testing as part of their clinical assessment and management. The cardiac intensivist and staff also serve as a consultative resource throughout the hospital to other clinicians given the clinical expertise of the CICU in the management of critically ill patients with cardiovascular complications of COVID-19. abstract: Critical care cardiology has been impacted by the coronavirus disease-2019 (COVID-19) pandemic. COVID-19 causes severe acute respiratory distress syndrome, acute kidney injury, as well as several cardiovascular complications including myocarditis, venous thromboembolic disease, cardiogenic shock, and cardiac arrest. The cardiac intensive care unit is rapidly evolving as the need for critical care beds increases. Herein, we describe the changes to the cardiac intensive care unit and the evolving role of critical care cardiologists and other clinicians in the care of these complex patients affected by the COVID-19 pandemic. These include practical recommendations regarding a structural and organizational changes to facilitate care of patients with COVID-19; staffing and personnel changes; and health and safety of personnel. We draw upon our own experiences at NewYork-Presbyterian Columbia University Irving Medical Center to offer insights into the unique challenges facing critical care clinicians and provide recommendations of how to address these challenges during this unprecedented time. url: https://www.ncbi.nlm.nih.gov/pubmed/32682106/ doi: 10.1016/j.ahj.2020.06.018 id: cord-005569-9d51l6bn author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia date: 2008-12-09 words: 10270.0 sentences: 507.0 pages: flesch: 39.0 cache: ./cache/cord-005569-9d51l6bn.txt txt: ./txt/cord-005569-9d51l6bn.txt summary: Key recommendations, listed by category, include: early goal-directed resuscitation of the septic patient during the first 6 h after recognition (1C); blood cultures prior to antibiotic therapy (1C); imaging studies performed promptly to confirm potential source of infection (1C); administration of broad-spectrum antibiotic therapy within 1 h of diagnosis of septic shock (1B) and severe sepsis without septic shock (1D); reassessment of antibiotic therapy with microbiology and clinical data to narrow coverage, when appropriate (1C); a usual 7-10 days of antibiotic therapy guided by clinical response (1D); source control with attention to the balance of risks and benefits of the chosen method (1C); administration of either crystalloid or colloid fluid resuscitation (1B); fluid challenge to restore mean circulating filling pressure (1C); reduction in rate of fluid administration with rising filling pressures and no improvement in tissue perfusion (1D); vasopressor preference for norepinephrine or dopamine to maintain an initial target of mean arterial pressure [ or =65 mm Hg (1C); dobutamine inotropic therapy when cardiac output remains low despite fluid resuscitation and combined inotropic/vasopressor therapy (1C); stress-dose steroid therapy given only in septic shock after blood pressure is identified to be poorly responsive to fluid and vasopressor therapy (2C); recombinant activated protein C in patients with severe sepsis and clinical assessment of high risk for death (2B except 2C for post-operative patients). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094904/ doi: 10.1007/s00134-008-1371-6 id: cord-005750-54hul2lw author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea date: 2009-02-10 words: 8228.0 sentences: 436.0 pages: flesch: 44.0 cache: ./cache/cord-005750-54hul2lw.txt txt: ./txt/cord-005750-54hul2lw.txt summary: In their paper, the authors present a detailed description of sequential analysis methodologies and describe their potential prospective use as tools for monitoring the performance of intensive care units. [2] undertook a study to determine whether outcomes were influenced by time of admission to an Australian tertiary paediatric intensive care unit without 24 h per day in-house intensivist cover. [6] who reported a prospective observational study across 15 Italian paediatric intensive care units conducted over a period of 1 year. In this randomised controlled trial, there was a significant difference in mortality rate with use of ACCM/ PALS haemodynamic support guidelines for septic shock between patients with or without ScvO 2 guided therapy. The authors concluded that their results support the finding that the clinical scales do not evaluate the level of sedation accurately in critically ill children with neuromuscular relaxation, leading to a higher risk of over or undersedation. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095358/ doi: 10.1007/s00134-009-1433-4 id: cord-283969-wqrzaxsu author: Antonucci, Michele title: The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis date: 2020-10-28 words: 2927.0 sentences: 157.0 pages: flesch: 44.0 cache: ./cache/cord-283969-wqrzaxsu.txt txt: ./txt/cord-283969-wqrzaxsu.txt summary: title: The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis Introduction and objectives We aimed to evaluate how the corona virus disease of 2019 (COVID-19) outbreak influenced emergency department (ED) admissions for urolithiasis, hospitalizations and clinical management of the hospitalized Patients. 3 Urolithiasis represents a frequent cause of ED admissions, accounting for 1%---2% of emergency visits 4 : in a report from a large series of patients admitted to ED in a big Italian hospital, 16% of patients with non-traumatic abdominal pain had a diagnosis of renal or ureteral stone. We performed a multicentric retrospective analysis of ED admissions for urolithiasis in three high volume urology department (>100 surgical procedures for stone disease per year) in Rome -Italy between March and April 2020 and in the same period of 2019. abstract: Introduction and objectives We aimed to evaluate how the corona virus disease of 2019 (COVID-19) outbreak influenced emergency department (ED) admissions for urolithiasis, hospitalizations and clinical management of the hospitalized Patients. Patients and methods We conducted a multicentric retrospective analysis of ED admissions in three high volume urology departments (one directly involved in COVID-19 patients management and two not involved) in Rome - Italy between March and April 2020 and in the same period of 2019. Statistical analysis was conducted on the number of admissions for urolithiasis, rate of complications, hospitalization and the type of treatment received. Results 304 patients were included in the analysis. A significant reduction in the global number of patients admitted to ED for urolithiasis between 2019 and 2020 (48.8%) was noted. Moreover, regarding the choice of treatment of hospitalized patients, a statistically significant increase of stone removal procedures versus urinary drainage was reported in 2020 (P = .015). Conclusions During the COVID-19 pandemic in Rome there has been a significant reduction of emergency admissions for urolithiasis. Patients admitted to ED had more complications, more frequently need hospitalization and regarding clinical management early stone removal was preferred over urinary drainage only. All the urologists should be aware that in the next months they could face an increased number of admissions for urolithiasis and manage more complicated cases. url: https://api.elsevier.com/content/article/pii/S217357862030130X doi: 10.1016/j.acuroe.2020.10.006 id: cord-272975-gzsd4ybt author: Antony, Arun title: Systematic review of EEG findings in 617 patients diagnosed with COVID-19 date: 2020-10-19 words: 3554.0 sentences: 237.0 pages: flesch: 46.0 cache: ./cache/cord-272975-gzsd4ybt.txt txt: ./txt/cord-272975-gzsd4ybt.txt summary: Significance EEG abnormalities are common in COVID-19 related encephalopathy and correlates with disease severity, preexisting neurological conditions including epilepsy and prolonged EEG monitoring. [6] [7] [8] Individual studies stress a specific population demographic or peculiar aspect of the EEG, but together provide a mosaic of EEG findings in varied groups from children to elderly, and asymptomatic patients to those with severe encephalopathy and status epilepticus. Here, we perform a systematic study of the EEG findings in patients with COVID-19 to synthesize the available data and to elucidate common patterns. Of interest, frontal lobe findings were common and included focal slowing, Diffuse background slowing was the most common EEG finding reported in two-thirds (68.6%) of patients indicating that a diffuse non-specific encephalopathy was the most common brain abnormality in this condition. The earliest available report of neurological complication of SARS-COV infection was a patient with respiratory failure and seizures, although EEG was not performed. abstract: Objective We performed a systematic review of the literature to synthesize the data on EEG findings in COVID-19. Frontal EEG patterns are reported to be a characteristic finding in COVID-19 encephalopathy. Although several reports of EEG abnormalities are available, there is lack of clarity about typical findings. Methods Research databases were queried with the terms “COVID” OR “coronavirus” OR “SARS” AND “EEG”. Available data was analyzed from 617 patients with EEG findings reported in 84 studies. Results The median age was 61.3 years (IQR 45−69, 33.3 % female). Common EEG Indications were altered mental status (61.7 %), seizure-like events (31.2 %), and cardiac arrest (3.5 %). Abnormal EEG findings (n = 543, 88.0 %) were sub-classified into three groups: (1) Background abnormalities: diffuse slowing (n = 423, 68.6 %), focal slowing (n = 105, 17.0 %), and absent posterior dominant rhythm (n = 63, 10.2 %). (2) Periodic and rhythmic EEG patterns: generalized periodic discharges (n = 35, 5.7 %), lateralized/multifocal periodic discharges (n = 24, 3.9 %), generalized rhythmic activity (n = 32, 5.2 %). (3) Epileptiform changes: focal (n = 35, 5.7 %), generalized (n = 27, 4.4 %), seizures/status epilepticus (n = 34, 5.5 %). Frontal EEG patterns comprised of approximately a third of all findings. In studies that utilized continuous EEG, 96.8 % (n = 243) of the 251 patients were reported to have abnormalities compared to 85.0 % (n = 311) patients who did not undergo continuous EEG monitoring (χ2 = 22.8, p =< 0.001). Significance EEG abnormalities are common in COVID-19 related encephalopathy and correlates with disease severity, preexisting neurological conditions including epilepsy and prolonged EEG monitoring. Frontal findings are frequent and have been proposed as a biomarker for COVID-19 encephalopathy. url: https://api.elsevier.com/content/article/pii/S1059131120303320 doi: 10.1016/j.seizure.2020.10.014 id: cord-338605-3i5pvcgu author: Antoun, Lina title: Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome A prospective cohort study date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To study the effect of COVID-19 on pregnancy and neonatal outcomes. STUDY DESIGN: Prospective cohort study in a large tertiary maternity unit within a university hospital with an average annual birth of over 10,000 births. We prospectively collected and analysed data for a cohort of 23 pregnant patients including singleton and multiple pregnancies tested positive for COVID-19 between February 2020 and April 2020 inclusive to assess the effect of COVID-19 on pregnancy, and neonatal outcomes. RESULTS: Twenty-three pregnant patients tested positive for COVID-19, delivering 20 babies including a set of twins, with four ongoing pregnancies at the time of manuscript submission. 16/23 (70%) whom tested positive were patients from Asian (Indian sub-continent) background. The severity of the symptoms ranged from mild in 13/23 (65.2%) of the patients, moderate in 2/23 (8.7%), and severe in 8/23 (34.8%). Four out of total 23 COVID-19 pregnant patients (17.4%) developed severe adult respiratory distress syndrome complications requiring ICU support, one of whom led to maternal death 1/23 (4.3%). 11/23 (48%) of the patients had pre-existing co-morbidities, with morbid obesity 5/23 (21.7%) and diabetes 4/23 (17.4%) being the more commonly represented. Of the 23 pregnant patients 19 were in their third trimester of pregnancy and delivered; 7/19 (36.8%) had preterm birth, 3/19 (15.8%) developed adult respiratory distress syndrome before delivery, and 2/19 (10.5%) had pre-eclampsia. 16/19 (84%) of patients delivered by C-section. Out of the 20 new-borns, 18 were singletons with a set of twin. CONCLUSION: COVID-19 is associated with high prevalence of preterm birth, preeclampsia, and caesarean section compared to non-COVID pregnancies. COVID-19 infection was not found in the newborns and none developed severe neonatal complications. url: https://doi.org/10.1016/j.ejogrb.2020.07.008 doi: 10.1016/j.ejogrb.2020.07.008 id: cord-287895-63wy5ztb author: Aponte Martín, Diego Mauricio title: Use of a new face shield for patients of the endoscopy unit to avoid aerosol exchange in the COVID-19 era date: 2020-07-04 words: 932.0 sentences: 73.0 pages: flesch: 61.0 cache: ./cache/cord-287895-63wy5ztb.txt txt: ./txt/cord-287895-63wy5ztb.txt summary: title: Use of a new face shield for patients of the endoscopy unit to avoid aerosol exchange in the COVID-19 era Because these procedures are performed in a contaminated environment, there is a higher risk that patients and health workers will be infected. Although there is an absence of new data about transmission of the virus as an aerosol, a previous study revealed that health workers who are exposed to this kind of procedure have a 4.66 times greater probability (95% confidence interval, 3.1-6.9) of infection in comparison with others. Our current interest in the Colombia University endoscopic unit is to decrease as much as possible aerosol contamination from patients and health workers. In conclusion, we have found that wearing the face shield we have specially designed results in less contact between the patient and the environment and yields an important decrease in the quantity of droplets and aerosols produced during the procedure. Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2468448120301831 doi: 10.1016/j.vgie.2020.05.033 id: cord-318954-pj5lsvsa author: Arabi, Yaseen title: Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol date: 2015-11-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As of September 30, 2015, a total of 1589 laboratory-confirmed cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization (WHO). At present there is no effective specific therapy against MERS-CoV. The use of convalescent plasma (CP) has been suggested as a potential therapy based on existing evidence from other viral infections. We aim to study the feasibility of CP therapy as well as its safety and clinical and laboratory effects in critically ill patients with MERS-CoV infection. We will also examine the pharmacokinetics of the MERS-CoV antibody response and viral load over the course of MERS-CoV infection. This study will inform a future randomized controlled trial that will examine the efficacy of CP therapy for MERS-CoV infection. In the CP collection phase, potential donors will be tested by the enzyme linked immunosorbent assay (ELISA) and the indirect fluorescent antibody (IFA) techniques for the presence of anti-MERS-CoV antibodies. Subjects with anti-MERS-CoV IFA titer of ≥1:160 and no clinical or laboratory evidence of MERS-CoV infection will be screened for eligibility for plasma donation according to standard donation criteria. In the CP therapy phase, 20 consecutive critically ill patients admitted to intensive care unit with laboratory-confirmed MERS-CoV infection will be enrolled and each will receive 2 units of CP. Post enrollment, patients will be followed for clinical and laboratory outcomes that include anti-MERS-CoV antibodies and viral load. This protocol was developed collaboratively by King Abdullah International Medical Research Center (KAIMRC), Gulf Cooperation Council (GCC) Infection Control Center Group and the World Health Organization—International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC-WHO) MERS-CoV Working Group. It was approved in June 2014 by the Ministry of the National Guard Health Affairs Institutional Review Board (IRB). A data safety monitoring board (DSMB) was formulated. The study is registered at http://www.clinicaltrials.gov (NCT02190799). url: https://www.ncbi.nlm.nih.gov/pubmed/26618098/ doi: 10.1186/s40064-015-1490-9 id: cord-003520-f3jz59pt author: Arabi, Yaseen M. title: Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date: 2019-02-13 words: 4280.0 sentences: 211.0 pages: flesch: 51.0 cache: ./cache/cord-003520-f3jz59pt.txt txt: ./txt/cord-003520-f3jz59pt.txt summary: title: Free Fatty Acids'' Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial Objectives: The objectives of this study were to evaluate the clinical and nutritional correlates of high free fatty acids (FFAs) level in critically ill patients and the association with outcomes, and to study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. Conclusion: We conclude that high FFAs level in critically ill patients is associated with features of metabolic syndrome and is not affected by short-term permissive underfeeding. The aims of this study were (1) to evaluate the clinical and nutritional correlates of high FFAs level in critically ill patients and the association with outcomes, and (2) study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. abstract: Objectives: The objectives of this study were to evaluate the clinical and nutritional correlates of high free fatty acids (FFAs) level in critically ill patients and the association with outcomes, and to study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. Patients/Method: In this pre-planned sub-study of the PermiT (Permissive Underfeeding vs. Target Enteral Feeding in Adult Critically Ill Patients) trial, we included critically ill patients who were expected to stay for ≥14 days in the intensive care unit. We measured FFAs level on day 1, 3, 5, 7, and 14 of enrollment. Of 70 enrolled patients, 23 (32.8%) patients had high FFAs level (baseline FFAs level >0.45 mmol/L in females and >0.6 mmol/L in males). Results: Patients with high FFAs level were significantly older and more likely to be females and diabetics and they had lower ratio of partial pressure of oxygen to the fraction of inspired oxygen, higher creatinine, and higher total cholesterol levels than those with normal FFAs level. During the study period, patients with high FFAs level had higher blood glucose and required more insulin. On multivariable logistic regression analysis, the predictors of high baseline FFAs level were diabetes (adjusted odds ratio (aOR): 5.36; 95% confidence interval (CI): 1.56, 18.43, p = 0.008) and baseline cholesterol level (aOR, 4.29; 95% CI: 11.64, 11.19, p = 0.003). Serial levels of FFAs did not differ with time between permissive underfeeding and standard feeding groups. FFAs level was not associated with 90-day mortality (aOR: 0.49; 95% CI: 0.09, 2.60, p = 0.40). Conclusion: We conclude that high FFAs level in critically ill patients is associated with features of metabolic syndrome and is not affected by short-term permissive underfeeding. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412238/ doi: 10.3390/nu11020384 id: cord-010856-3g0123lk author: Araghi, Ariyan S. title: An audit to analyse the two-week wait pathway at an oral cancer specialist district general hospital date: 2020-05-08 words: 5099.0 sentences: 278.0 pages: flesch: 60.0 cache: ./cache/cord-010856-3g0123lk.txt txt: ./txt/cord-010856-3g0123lk.txt summary: Cross-pathway referral for these cancers allows both general medical practitioners (GMPs) and general dental practitioners (GDPs) to refer patients to be seen within two weeks by a specialist secondary care consultant in an oral maxillofacial cancer unit. To analyse whether the positively diagnosed cancer patients were being given their initial diagnosis within 28 days, in preparation for the new guidelines to be implemented in the NHS Long Term Plan (2020) 5. One hundred percent of the patients positively diagnosed with cancer would receive diagnosis within 28 days and subsequent treatment within 62 days in line with the current guidelines for the 2ww referral system for HNCs. The standard for diagnostic cancer yield/positive oncological transformation would be set at 3%, as appropriate for a screening test as set out by NHS England. abstract: Background The incidence of head and neck cancers is increasing, alongside a decrease in associated mortality. Currently, medical and dental practitioners can refer patients to be seen urgently within two weeks. The appropriateness of these referrals has been disputed. In 2020, the Department of Health aims for patients to be given cancer diagnoses within 28 days from referral. Methods A retrospective audit was conducted for all patients referred under the two-week wait pathway in a six-month period. In the first cycle of this audit, one month's worth of urgent referrals were analysed; given the small sample size, very few recommendations could be made. The audit cycle was repeated and it analysed six months' worth of data, which gave a much more representative study. All patients were analysed to see if the 14-day period had been breached. Positive cancer patients were further assessed to see if their diagnosis had been given within 28 days and treatments within 62 days. Results Of the 569 patients seen, there was a positive malignancy diagnostic yield of 7.38%. Nineteen patients breached the 14-day wait. Of the positive patients, 45.2% received their diagnosis more than 28 days from referral, and 22.2% of these patients received treatment after 62 days. Conclusion The department performed well despite the high number of referrals. This audit has touched on some key issues which have been discussed in detail in this article. Furthermore, this audit recommends a concerted effort to improve oral cancer detections skills among GDPs and GMPs. While all referrals may be appropriate from a primary care point of view, this audit makes it apparent that better differentiation is needed between malignant and routinely manageable lesions. All secondary care units alongside general practitioners can learn from the findings of this audit. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222898/ doi: 10.1038/s41415-020-1449-2 id: cord-329564-tmi1u224 author: Arashiro, Takeshi title: COVID-19 in 2 Persons with Mild Upper Respiratory Tract Symptoms on a Cruise Ship, Japan date: 2020-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We describe 2 cases of coronavirus disease in patients with mild upper respiratory symptoms. Both patients worked on a cruise ship quarantined off the coast of Japan. One patient had persistent, low-grade upper respiratory tract symptoms without fever. The other patient had rapid symptom cessation but persistent viral RNA detection. url: https://doi.org/10.3201/eid2606.200452 doi: 10.3201/eid2606.200452 id: cord-310901-oooat8xj author: Arca, Karissa N. title: COVID‐19 and Headache Medicine: A Narrative Review of Non‐Steroidal Anti‐Inflammatory Drug (NSAID) and Corticosteroid Use date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To summarize the current literature on non‐steroidal anti‐inflammatory drug and corticosteroid use during the coronavirus disease 2019 (COVID‐19) pandemic, recognizing that these are commonly used treatments in the field of headache medicine. BACKGROUND: The use of non‐steroidal anti‐inflammatory drugs and corticosteroids in patients during the COVID‐19 pandemic has been a controversial topic within the medical community and international and national health organizations. Lay press and social media outlets have circulated opinions on this topic despite the fact that the evidence for or against the use of these medications is sparse. In the field of headache medicine, these medications are used commonly and both patients and clinicians may have questions or hesitations pertaining to their use during the COVID‐19 pandemic. METHODS: A detailed search of the scientific and popular literature was performed. RESULTS: There is limited literature pertaining to the safety of non‐steroidal anti‐inflammatory drugs and corticosteroids during the COVID‐19 pandemic. To date, there are no clear scientific data that preclude the use of non‐steroidal anti‐inflammatory drugs in the general population who may acquire COVID‐19 or in those acutely infected with the virus. Several health organizations have concluded that treatment with corticosteroids during active infection should be avoided due to concerns of prolonged viral shedding in the respiratory tract and the lack of survival benefit based on the data from past coronaviruses and influenza virus; specific exceptions exist including treatment for underlying asthma or chronic obstructive pulmonary disease, septic shock, and acute respiratory distress syndrome. CONCLUSION: Scientific information regarding the COVID‐19 pandemic is constantly evolving, and limited or contradictory information can lead to confusion for both patients and clinicians. It is recommended that prior to prescribing non‐steroidal anti‐inflammatory drugs and steroids for the treatment of headache, clinicians have open discussions with their patients about the potential risks and benefits of using these medications during the COVID‐19 pandemic. This manuscript summarizes the currently available evidence and understanding about these risks and benefits to help clinicians navigate such discussions. url: https://doi.org/10.1111/head.13903 doi: 10.1111/head.13903 id: cord-012115-hpsxi9ay author: Archie, Patrick title: Music-based interventions in palliative cancer care: a review of quantitative studies and neurobiological literature date: 2013-05-30 words: 6729.0 sentences: 279.0 pages: flesch: 38.0 cache: ./cache/cord-012115-hpsxi9ay.txt txt: ./txt/cord-012115-hpsxi9ay.txt summary: The Cochrane Library, Ovid, PubMed, CINAHL Plus, PsycINFO, and ProQuest were searched for the subject headings music, music therapy, cancer, oncology, palliative care, pain, anxiety, depression, mood, quality of life, prevalence, neuroscience, functional imaging, endogenous opioids, GABA, 5HT, dopamine, and permutations of these same search terms. RESULTS: Available evidence suggests that music-based interventions may have a positive impact on pain, anxiety, mood disturbance, and quality of life in cancer patients. b Inferior view of neuroanatomic regions affected by music (and implicated in the pathophysiology of pain, anxiety, and/or depression) outcome to cancer patients in palliative care settings, future studies investigating the effect of music-based interventions on pain, anxiety, or mood disturbance in this patient population should incorporate QOL measurements into their outcome assessment. abstract: PURPOSE: This study aimed to review quantitative literature pertaining to studies of music-based interventions in palliative cancer care and to review the neurobiological literature that may bare relevance to the findings from these studies. METHODS: A narrative review was performed, with particular emphasis on RCTs, meta-analyses, and systematic reviews. The Cochrane Library, Ovid, PubMed, CINAHL Plus, PsycINFO, and ProQuest were searched for the subject headings music, music therapy, cancer, oncology, palliative care, pain, anxiety, depression, mood, quality of life, prevalence, neuroscience, functional imaging, endogenous opioids, GABA, 5HT, dopamine, and permutations of these same search terms. Data for the review were comprised of articles published between 1970 and 2012. References of all the cited articles were also reviewed. RESULTS: Available evidence suggests that music-based interventions may have a positive impact on pain, anxiety, mood disturbance, and quality of life in cancer patients. Advances in neurobiology may provide insight into the potential mechanisms by which music impacts these outcomes. CONCLUSIONS: More research is needed to determine what subpopulation of cancer patients is most likely to respond to music-based interventions, what interventions are most effective for individual outcomes, and what measurement parameters best gauge their effectiveness. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728458/ doi: 10.1007/s00520-013-1841-4 id: cord-344104-592r71l1 author: Ardati, Amer K. title: Be Prepared date: 2020-03-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32182130/ doi: 10.1161/circoutcomes.120.006661 id: cord-287048-5od0ssyk author: Areaux, Raymond G. title: Your eye doctor will virtually see you now: synchronous patient-to-provider virtual visits in pediatric tele-ophthalmology date: 2020-08-03 words: 3046.0 sentences: 160.0 pages: flesch: 43.0 cache: ./cache/cord-287048-5od0ssyk.txt txt: ./txt/cord-287048-5od0ssyk.txt summary: Summary Community transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) in the United States on February 26, 2020, and the rapid spread that followed forced patients, providers, payors, and policy makers to adapt to an unprecedented, nearly instant, and enormous demand for virtual care. The arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, or COVID-19) obliterated these barriers as executive orders forced patients, providers, and payors to adapt to an unprecedented, nearly instant, and enormous demand for virtual care. Regarding the use of synchronous patient-to-provider virtual visits (SPPVV) in pediatric ophthalmology, we have pooled our collective experience at three academic practices across the country to describe initial workflows, technology solutions, use cases, and barriers to care. Regarding the use of synchronous patient-to-provider virtual visits (SPPVV) in pediatric ophthalmology, we have pooled our collective experience at three academic practices across the country to describe initial workflows, technology solutions, use cases, and barriers to care. abstract: Summary Community transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) in the United States on February 26, 2020, and the rapid spread that followed forced patients, providers, payors, and policy makers to adapt to an unprecedented, nearly instant, and enormous demand for virtual care. Although few US ophthalmology practices incorporated telemedicine prior to COVID-19, its use has now become the norm. Regarding the use of synchronous patient-to-provider virtual visits (SPPVV) in pediatric ophthalmology, we have pooled our collective experience at three academic practices across the country to describe initial workflows, technology solutions, use cases, and barriers to care. url: https://api.elsevier.com/content/article/pii/S1091853120301555 doi: 10.1016/j.jaapos.2020.06.004 id: cord-323489-ro7kbnu3 author: Arenas, María Dolores title: Protection of nephrology health professionals during the COVID-19 pandemic date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 epidemic represents a special risk for kidney patients due to their comorbidities and advanced age, and the need for hemodialysis treatment in group rooms. It also represents a risk for professionals responsible for their attention. This manuscript contains a proposal for action to prevent infection of professionals in the Nephrology Services, one of the most valuable assets at the present time. url: https://api.elsevier.com/content/article/pii/S2013251420301061 doi: 10.1016/j.nefroe.2020.06.018 id: cord-280348-vrnxucye author: Argano, Christiano title: Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry date: 2020-07-27 words: 4641.0 sentences: 257.0 pages: flesch: 39.0 cache: ./cache/cord-280348-vrnxucye.txt txt: ./txt/cord-280348-vrnxucye.txt summary: Chronic obstructive pulmonary disease (COPD) represents an important leading cause of morbidity and mortality with high economic and social costs: according to the WHO, COPD is the fourth most common cause of death worldwide, and it is estimated to be the third by 2020; furthermore, the global burden of COPD is expected to increase in the coming years, due to the prevalence of smoking and aging of the world population [1] . The following clinical characteristics were evaluated: respiratory and non-respiratory disease distribution at hospital admission (according to International Classification of Diseases-Ninth Revision); cognitive status and mood disorders (by the Short-Blessed-Test [SBT] [9] and the Geriatric-Depression-Scale [GDS] [10] ,respectively; performance in activities of daily living at hospital admission (measured by means of the Barthel Index [BI] [11] ; severity and comorbidity index(assessed by the Cumulative-Illness-Rating-Scale CIRS-s and CIRS-c, respectively) [12] , glomerular filtration rate (using the Chronic Kidney Disease Epidemiology Collaboration-formula [13] ), length of hospital stay, drugs prescriptions (at admission, discharge, at 3 and 12 months follow-up), destination at discharge, in-hospital and 3-month and 1-year mortality rate. abstract: Currently, chronic obstructive pulmonary disease (COPD) represents the fourth cause of death worldwide with significant economic burden. Comorbidities increase in number and severity with age and are identified as important determinants that influence the prognosis. In this observational study, we retrospectively analyzed data collected from the RePoSI register. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients with the clinical diagnosis of COPD. Socio-demographic, clinical characteristics and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up were analyzed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Patients with COPD had more hospitalization, a significant overt cognitive impairment, a clinically significant disability and more depression in comparison with non-COPD subjects. COPD patients took more drugs, both at admission, in-hospital stay, discharge and 3-month and 1-year follow-up. 14 comorbidities were more frequent in COPD patients. Cerebrovascular disease was an independent predictor of in-hospital mortality. At 3-month follow-up, male sex and hepatic cirrhosis were independently associated with mortality. ICS-LABA therapy was predictor of mortality at in-hospital, 3-month and 1-year follow-up. This analysis showed the severity of impact of COPD and its comorbidities in the real life of internal medicine and geriatric wards. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11739-020-02412-1) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32720248/ doi: 10.1007/s11739-020-02412-1 id: cord-297425-vcqqssm8 author: Aries, James A. title: Clinical Outcome of Coronavirus Disease 2019 in Haemato‐oncology Patients date: 2020-05-18 words: 1402.0 sentences: 76.0 pages: flesch: 49.0 cache: ./cache/cord-297425-vcqqssm8.txt txt: ./txt/cord-297425-vcqqssm8.txt summary: However, the prognosis varies widely between groups, with age over 60 years and underlying conditions including hypertension, diabetes, cardiovascular disease and cancer identified as risk factors for severe disease and death.(3) The initial reports from China show that patients with cancer are over‐represented among individuals who develop severe Covid‐19 after contracting the virus.(4) Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy. (3) The initial reports from China show that patients with cancer are over-represented among individuals who develop severe Covid-19 after contracting the virus.(4) Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy. abstract: Since being identified in China in December 2019, coronavirus disease 2019 (Covid‐19) has rapidly evolved into a global pandemic with over 4 million cases and more than 270,000 deaths.(1) Following the first reported cases in the United Kingdom (UK) in late January 2020, numbers have continued to rise with 223,060 cases and 32,065 deaths reported as of 11(th) May 2020.(2) Initial reports from China have indicated that Covid‐19 has an overall mortality rate of 1.4%. However, the prognosis varies widely between groups, with age over 60 years and underlying conditions including hypertension, diabetes, cardiovascular disease and cancer identified as risk factors for severe disease and death.(3) The initial reports from China show that patients with cancer are over‐represented among individuals who develop severe Covid‐19 after contracting the virus.(4) Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy. url: https://doi.org/10.1111/bjh.16852 doi: 10.1111/bjh.16852 id: cord-308195-nlibv0u4 author: Arleo, T. L. title: Clinical Course and Outcomes of coronavirus disease 2019 (COVID-19) in Rheumatic Disease Patients on Immunosuppression: A case Cohort Study at a Single Center with a Significantly Diverse Population date: 2020-10-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objectives To determine clinical course and outcomes in rheumatic disease patients with coronavirus disease 2019 (COVID-19) and compare results to uninfected patients. Methods We conducted a case cohort study of autoimmune disease patients with COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR) from 02/01/2020 to 07/31/2020 and compared them in a 1:3 ratio with uninfected patients who were matched based on race, age, sex, and comorbidity index. Patient demographics, clinical course, and outcomes were compared among these patient groups. Results A total of 70 rheumatic disease patients with COVID-19 (mean age, 56.6 years; 64% African American) were identified. The 34 (49%) patients who were hospitalized used oral glucocorticoids more frequently (p<0.01). All 10 patients on anti-TNF medications were treated as outpatients (p<0.01). Those hospitalized with COVID-19 more often required ICU admission (17 (50%) vs 27 (26%), OR=2.78 (95% CI: 1.24 to 6.20)) and intubation (10 (29%) vs 6 (6%), OR=6.67 (95% CI: 2.20 to 20.16)) than uninfected patients. They also had higher mortality rates (6 (18%) vs 3 (3%), OR=7.21 (95% CI: 1.70 to 30.69)). Of the six COVID-19 patients who died, one was of African ancestry (p=0.03). Conclusions Rheumatic disease patients infected with COVID-19 were more likely to require ICU admission, ventilation, and died more frequently versus uninfected patients with autoimmune disease. Patients on anti-TNF medications were hospitalized less frequently while those on chronic glucocorticoids were hospitalized more frequently. These findings have important implications for medication choice in rheumatic disease patients during the ongoing spread of COVID-19. url: http://medrxiv.org/cgi/content/short/2020.10.26.20219154v1?rss=1 doi: 10.1101/2020.10.26.20219154 id: cord-018110-mcw4v13c author: Arnold, Andreas title: Inner Ear date: 2010 words: 15854.0 sentences: 980.0 pages: flesch: 46.0 cache: ./cache/cord-018110-mcw4v13c.txt txt: ./txt/cord-018110-mcw4v13c.txt summary: In the case of partial or no remission, prednisolone treatment should be continued orally for 16 days together with gastric proton pump inhibitors and additional haemodilutive/haemorheological infusion therapy together with α-lipoic acid should be administered as described for high-frequency idiopathic sensorineural hearing loss. Acute tinnitus due to noise-induced damage or acoustic trauma of the inner ear, idiopathic sensorineural hearing loss (sudden deafness), acute attack of Ménière''s disease, toxic labyrinthitis, rupture of the round window, perilymphatic fistula of the round or oval window, labyrinthine contusion or fractures of the temporal bone due to head trauma should be treated with a daily dose of 250-500 mg prednisolone intravenously on three consecutive days. abstract: Herpes zoster oticus, herpes zoster cephalicus, Ramsay Hunt syndrome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122903/ doi: 10.1007/978-3-540-68940-9_6 id: cord-288371-uyj4iske author: Arrieta, Oscar title: Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: The THOCOoP cooperative group date: 2020-06-20 words: 6664.0 sentences: 382.0 pages: flesch: 46.0 cache: ./cache/cord-288371-uyj4iske.txt txt: ./txt/cord-288371-uyj4iske.txt summary: Long-term Follow-up on NRG Oncology RTOG 0915 (NCCTG N0927): A Randomized Phase 2 Study Comparing 2 Stereotactic Body Radiation Therapy Schedules for Medically Inoperable Patients With Stage I Peripheral Non-Small Cell Lung Cancer Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial. Phase III study of the Eastern Cooperative Oncology Group (ECOG 2597): induction chemotherapy followed by either standard thoracic radiotherapy or hyperfractionated accelerated radiotherapy for patients with unresectable stage IIIA and B non-small-cell lung cancer Usefulness of serum carcinoembryonic antigen (CEA) in evaluating response to chemotherapy in patients with advanced non small-cell lung cancer: a prospective cohort study Randomized phase III trial of single-agent pemetrexed versus carboplatin and pemetrexed in patients with advanced non-small-cell lung cancer and Eastern Cooperative Oncology Group performance status of 2 Carboplatin-or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data abstract: The world currently faces a pandemic due to SARS-CoV-2. Relevant information has emerged regarding the higher risk of poor outcomes in lung cancer patients. As such, lung cancer patients must be prioritized in terms of prevention, detection and treatment. On May 7th, 45 experts in thoracic cancers from 11 different countries were invited to participate. A core panel of experts regarding thoracic oncology care amidst the pandemic gathered virtually, and a total of 60 initial recommendations were drafted based on available evidence. By May 16th, 44 experts had agreed to participate, and voted on each recommendation using a Delphi panel on a live voting event. Consensus was reached regarding the recommendations (>66% strongly agree/agree) for 57 questions. Strong consensus (>80% strongly agree/agree) was reached for 45 questions. Patients with lung cancer represent a particularly vulnerable population during this time. Special care must be taken to maintain treatment while avoiding exposure. url: https://api.elsevier.com/content/article/pii/S1040842820301712 doi: 10.1016/j.critrevonc.2020.103033 id: cord-315871-anguylf1 author: Aschendorff, A. title: Quality of cochlear implant rehabilitation under COVID-19 conditions date: 2020-10-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The rehabilitation process following cochlear implant (CI) surgery is carried out in a multimodal therapy according to German national guidelines and includes technical and medical aftercare. In times of the corona pandemic surgery and rehabilitation appointments were cancelled or delayed leading to a more difficult access to auditory rehabilitation. Newly implemented hygiene modalities due to the SARS-CoV‑2 pandemic have changed medical aftercare and the rehabilitation process. The aim of this study was to evaluate the quality of rehabilitation under corona conditions. MATERIAL AND METHODS: An anonymous survey of adult cochlear implant patients was carried out by a non-standardized questionnaire. Demographics were analyzed and the quality of medical aftercare, speech therapy, technical aftercare, psychological support and the hygiene modalities were compared to previous rehabilitation stays. RESULTS: In total 109 patients completed the questionnaire. The quality of rehabilitation and individual therapy were rated as qualitatively similar or improved. The threat of the pandemic and fear of corona were rated unexpectedly high with 68% and 50%, respectively. The hygiene measures during the rehabilitation stay eased subjective fears at the same time. The majority of patients were annoyed by wearing face masks but visors, protection shields and social distancing were more tolerated. CONCLUSION: The implementation of the new hygiene modalities within the therapeutic rehabilitation setting was well-accepted by patients allowing access to auditory rehabilitation. A successful rehabilitation should ensure a fear-free environment by adhering to the necessary hygiene modalities. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00106-020-00923-z) includes the study questionnaire. Article and supplementary material are available at www.springermedizin.de. Please enter the title of the article in the search field, the supplementary material can be found under “Ergänzende Inhalte”. [Image: see text] url: https://www.ncbi.nlm.nih.gov/pubmed/33034674/ doi: 10.1007/s00106-020-00923-z id: cord-319742-ypkt01rn author: Asgharpour, Masoumeh title: Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19) date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Extracorporeal blood purification has been proposed as one of the therapeutic approaches in patients with coronavirus infection, because of its beneficial impact on elimination of inflammatory cytokines. METHODS: This controlled trial has been conducted on critically ill COVID-19 patients admitted in the state hospital affiliated to Babol University of Medical Sciences, Iran who received different antiviral and antibacterial drugs, and different modalities of respiratory treatments and did not have positive clinical improvement. No randomization and blindness was considered. All of the participants underwent three sessions of resin-directed hemoperfusion using continuous renal replacement therapy with a mode of continuous venovenous hemofiltration (CVVH). RESULTS: Five men and five women with a mean age of 57.30 ± 18.07 years have been enrolled in the study; and six of them have improved after the intervention. Peripheral capillary oxygen saturation (SpO2) changed after each session. Mean SpO2 before the three sessions of hemoperfusion was 89.60% ± 3.94% and increased to 92.13% ± 3.28% after them (p < 0.001). Serum IL-6 showed a reduction from 139.70 ± 105.62 to 72.06 ± 65.87 pg/mL (p = 0.073); and c-reactive protein decreased from 136.25 ± 84.39 to 78.25 ± 38.67 mg/L (P = 0.016). CONCLUSIONS: Extracorporeal hemoadsorption could improve the general condition in most of recruited patients with severe coronavirus disease; however, large prospective multicenter trials in carefully selected patients are needed to definitely evaluate the efficacy of hemoperfusion in COVID-19 patients. TRIAL REGISTRATION: The research protocol has been registered in the website of Iranian Registry of Clinical Trials with the reference number IRCT20150704023055N2. url: https://www.ncbi.nlm.nih.gov/pubmed/32819292/ doi: 10.1186/s12882-020-02020-3 id: cord-303791-yw80ndg6 author: Ashique, Karalikkattil T. title: Teledermatology in the Wake of COVID -19 Scenario: An Indian Perspective date: 2020-05-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32695684/ doi: 10.4103/idoj.idoj_260_20 id: cord-292394-91b3mm6c author: Ashish, A. title: Early CPAP reduced mortality in covid-19 patients. Audit results from Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust. date: 2020-06-02 words: 1717.0 sentences: 106.0 pages: flesch: 57.0 cache: ./cache/cord-292394-91b3mm6c.txt txt: ./txt/cord-292394-91b3mm6c.txt summary: The use of Continuous Positive Airway Pressure (CPAP) in patients with COVID-19 has now become established as a common clinical practice based on recent experience. Using routinely collected data, the use of CPAP as a supportive non-invasive ventilatory treatment is described in 35 patients with COVID infection. Although the analysis is affected by a small sample size, the results have shown good evidence that supports the early use of CPAP in patients with COVID-19 infection. . https://doi.org/10.1101/2020.05.28.20116152 doi: medRxiv preprint indicates a preference for early CPAP clinical strategy when treating patients with COVID-19. At this early stage in the treatment of COVID-19 respiratory infections the evidence presented supports the early use of CPAP in such patients. Continuous positive airway pressure and noninvasive ventilation in prehospital treatment of patients with acute respiratory failure: a systematic review of controlled studies abstract: COVID-19 infection typically causes pneumonia with bilateral changes on Chest radiograph. There is significant hypoxia and use of oxygen for patients admitted to hospital is standard. The use of Continuous Positive Airway Pressure (CPAP) in patients with COVID-19 has now become established as a common clinical practice based on recent experience. It is given as part of best endeavours treatment in the absence of sufficient evidence to guide best practice. The use of CPAP as a step up in clinical care is now common but has a poor evidence base. Using routinely collected data, the use of CPAP as a supportive non-invasive ventilatory treatment is described in 35 patients with COVID infection. Patients given early CPAP and in particular within 48 hours of admission, are shown to have a better outcome (a significant probability of lower mortality) than patients who received late CPAP (more than 48 hours after admission). Although the analysis is affected by a small sample size, the results have shown good evidence that supports the early use of CPAP in patients with COVID-19 infection. url: http://medrxiv.org/cgi/content/short/2020.05.28.20116152v1?rss=1 doi: 10.1101/2020.05.28.20116152 id: cord-288067-36amafub author: Ashraf, Mohammad Ali title: COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes date: 2020-04-24 words: 4374.0 sentences: 285.0 pages: flesch: 56.0 cache: ./cache/cord-288067-36amafub.txt txt: ./txt/cord-288067-36amafub.txt summary: Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and post-discharge follow-up were analyzed. The most common presenting symptoms are non-specific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. We reported detailed information about the potential source of exposure, household contact information, outcomes of potential therapies, and post-discharge follow-up, as well as demographic, clinical, and paraclinical characteristics. Patients who came to the hospital were examined by an infectious-disease specialist, and classified into three groups according to disease severity based on Iran''s national guideline for the diagnosis and treatment of COVID-19 in outpatients and inpatients (Figure1). We compared demographic characteristics, hospitalization data, and potential treatment outcomes in critically ill and non-critically ill patients. 12 Recent potential exposures, household contact information, demographics, clinical characteristics, laboratory, and radiologic findings, and patients'' outcomes were extracted as shown in table1. abstract: Purpose There is a growing need for information regarding the recent coronavirus disease of 2019 (Covid-19). We present a comprehensive report of Covid-19 patients in Iran. Methods One hundred hospitalized patients with Covid-19 were studied. Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and post-discharge follow-up were analyzed. Results The median age of the patients was 58 years, and the majority of the patients (72.7%) were above 50 years of age. Fever was present in 45.2% of the patients on admission. The most common clinical symptoms were shortness of breath (74%) and cough (68%). Most patients had elevated C-reactive protein (92.3%), elevated erythrocyte sedimentation rate (82.9%), lymphocytopenia (74.2 %) on admission. Lower lobes of the lung were most commonly involved, and ground-glass opacity (81.8%) was the most frequent finding in CT scans. The administration of hydroxychloroquine improved the clinical outcome of the patients. Lopinavir/ritonavir was efficacious at younger ages. Of the 70 discharged patients, 40% had symptom relapse, (8.6%) were readmitted to the hospital, and 3 patients (4.3%) died. Conclusion This report demonstrates a heterogeneous nature of clinical manifestations in patients affected with Covid-19. The most common presenting symptoms are non-specific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. Hydroxychloroquine and lopinavir/ritonavir (in younger age group) can be potential treatment options. Finally, patients discharged from the hospital should be followed up because of potential symptom relapse. url: https://doi.org/10.1101/2020.04.20.20072421 doi: 10.1101/2020.04.20.20072421 id: cord-305397-4dx3q6o6 author: Ashraf, Muddasir title: Seizures Related to Coronavirus Disease (COVID-19): Case Series and Literature Review date: 2020-07-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Neurological manifestations are common in coronavirus disease 2019 (COVID-19) patients. We present three cases of COVID-19 patients with seizures. Two patients had a history of seizures but very well controlled. They presented with seizure activity likely triggered by COVID-19. The third patient had no history of seizures and presented with new onset of seizure activity. All these patients were routinely screened for COVID-19 on admission and tested positive on nasopharyngeal real-time reverse transcriptase-polymerase chain reaction (rRT-PCR). None of these patients had respiratory symptoms. Electroencephalography (EEG) was abnormal in all three patients. All these patients recovered and were discharged in a stable condition. url: https://www.ncbi.nlm.nih.gov/pubmed/32850246/ doi: 10.7759/cureus.9378 id: cord-324159-jv3lknl8 author: Ashraf, Muddasir title: Acute Stroke in a Young Patient With Coronavirus Disease 2019 in the Presence of Patent Foramen Ovale date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We present an interesting case of acute ischemic stroke in a 26-year-old patient with coronavirus disease 2019, who presented to the hospital initially with headache, vomiting, and right-sided numbness and tingling. The initial workup was negative, including computed tomography (CT) of the head without contrast and CT angiography of the head and neck with no acute abnormalities. The patient was diagnosed with migraine and discharged from the emergency department. The patient developed worsening symptoms at home in the form of increasing right-sided dysmetria and weakness, gait ataxia, and dysarthria, prompting her to return to the emergency room. Magnetic resonance imaging of the brain was performed and was significant for right-sided acute ischemic cerebellar stroke, with also the involvement of the right cerebellar peduncle. Echocardiogram with a bubble study demonstrated patent foramen ovale. The patient was treated with standard guidelines for stroke. url: https://doi.org/10.7759/cureus.10233 doi: 10.7759/cureus.10233 id: cord-256508-ce59ovan author: Asselah, Tarik title: COVID-19: discovery, diagnostics and drug development date: 2020-10-08 words: 9214.0 sentences: 556.0 pages: flesch: 46.0 cache: ./cache/cord-256508-ce59ovan.txt txt: ./txt/cord-256508-ce59ovan.txt summary: To date, with the exception of intravenous Remdesivir and dexamethasone, which have modest effects in moderate to severe COVID-19, no strong clinical evidence supports the efficacy and safety of any other drugs against SARS-CoV-2. The current diagnostic strategy to identify patients with COVID-19 is to test samples taken from the respiratory tract to assess for the presence of SARS-CoV-2 specific nucleic acid targets [47] . The neutralization assay is a laboratory-based test that uses live virus and cell culture methods to determine if patient antibodies can prevent viral infection in vitro [72] . A randomized, controlled, openlabel trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection and severe respiratory illness COVID-19 was performed [126] . Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals abstract: An epidemic of acute respiratory syndrome (Covid-19) started in humans in Wuhan in 2019, and became a pandemic. Groups from China Identified and sequenced the virus responsible for COVID-19, named SARS-CoV-2, and determined that it was a novel coronavirus (CoV) that shared high sequence identity with bat- and pangolin-derived SARS-like CoVs, suggesting a zoonotic origin. SARS-CoV-2 is a member of Coronaviridae, a family of enveloped, positive-sense, single-stranded RNA viruses that infect a broad range of vertebrates. The rapid release of the sequence of the virus has allowed the development of diagnostic tools (e.g., RT-PCR). Additionally, serological tests can allow identification of persons who have been infected. In humans, CoVs tend to cause mild to moderate upper respiratory tract infections. The fatality rate is around 1-3% for infected persons. An acute respiratory distress syndrome (ARDS) likely due to an uncontrolled immune activation (“cytokine storm”) occurs in patients with severe disease and poor prognosis. Risk factors for mortality include: advanced age, obesity, diabetes, hypertension and other comorbidities. Drug repurposing has been used to rapidly identify potential treatment for COVID-19, which could move quickly to phase-3. Better knowledge of the virus, its enzymes, will be mandatory to develop more potent and specific direct-acting antiviral agents (DAA). In the long term, a vaccine to prevent infection would be crucial; however even if successful it might not be available before 2021-22. To date, with the exception of intravenous Remdesivir and dexamethasone, which have modest effects in moderate to severe COVID-19, no strong clinical evidence supports the efficacy and safety of any other drugs against SARS-CoV-2. The aim of this review is to provide insights on the discovery of SARS-CoV-2, its virology, the diagnostic tools, and the ongoing drug discovery effort. url: https://www.sciencedirect.com/science/article/pii/S0168827820336758?v=s5 doi: 10.1016/j.jhep.2020.09.031 id: cord-009285-1ddfywfa author: Assicot, M. title: High serum procalcitonin concentrations in patients with sepsis and infection date: 1993-02-27 words: 2593.0 sentences: 127.0 pages: flesch: 40.0 cache: ./cache/cord-009285-1ddfywfa.txt txt: ./txt/cord-009285-1ddfywfa.txt summary: By means of a monoclonal immunoradiometric assay for calcitonin precursors, we have measured serum concentrations of procalcitonin in patients with various bacterial and viral infections. Lancet 1993; 341: 518-21 Introduction About 3000 of the 30 000 people admitted to hospital in the UK each year for acute upper-gastrointestinal-tract bleeding will die.1 Prognostic indicators for outcome include: age, pulse rate, blood pressure, and haemoglobin at admission, and findings at endoscopy, such as presence, site, and nature of a bleeding lesion, and stigmata of recent bleeding.2-4 One factor that may promote continued bleeding and hence an adverse clinical outcome is the fibrinolytic activity of the upper gastrointestinal tract, because fibrinolysis may lead to digestion of haemostatic plugs.5 Consistent with this possibility, Poller and colleaguess demonstrated increased serum fibrin degradation products (FDP) in a small series of patients with acute upper-gastrointestinal-tract bleeding; however, the prognostic value of serum FDP concentrations has not been reported in a prospective study. abstract: High concentrations of calcitonin-like immunoreactivity have been found in the blood of patients with various extrathyroid diseases. By means of a monoclonal immunoradiometric assay for calcitonin precursors, we have measured serum concentrations of procalcitonin in patients with various bacterial and viral infections. 79 children (newborn to age 12 years) in hospital with suspected infections were investigated prospectively. 19 patients with severe bacterial infections had very high serum concentrations of procalcitonin at diagnosis (range 6-53 ng/mL) in comparison with 21 children found to have no signs of infection (baseline concentrations <0·1 ng/mL). Serum procalcitonin values decreased rapidly during antibiotic therapy. 11 patients with peripheral bacterial colonisation or local infections without invasive sepsis and 18 (86%) of 21 patients with viral infections had concentrations within or slightly above the normal range (0·1-1·5 ng/mL). Among 9 severely burned patients studied in an intensive care unit, the post-traumatic course of procalcitonin concentrations (range 0·1-120 ng/mL) was closely related to infectious complications and acute septic episodes. Concentrations of mature calcitonin were normal in all subjects, whatever procalcitonin concentrations were found. Concentrations of a substance immunologically identical to procalcitonin are raised during septic conditions. Serum concentrations seem to be correlated with the severity of microbial invasion. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141580/ doi: 10.1016/0140-6736(93)90277-n id: cord-268140-s5lailkp author: Atal, Shubham title: IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? date: 2020-06-13 words: 5174.0 sentences: 258.0 pages: flesch: 41.0 cache: ./cache/cord-268140-s5lailkp.txt txt: ./txt/cord-268140-s5lailkp.txt summary: Considering the proven role of cytokine dysregulation in causing this hyperinflammation in the lungs with IL-6 being a key driver, particularly in seriously ill COVID-19 patients, it is crucial to further explore selective cytokine blockade with drugs like the IL-6 inhibitors tocilizumab, sarilumab, and siltuximab. Considering the proven role of cytokine dysregulation in serious COVID-19 and interleukin (IL)-6 being the key driver of this hyperinflammation, which can cause multi-organ failure, a series of clinical trials with IL-6 inhibitors like tocilizumab, sarilumab and siltuximab are underway. Another Italian Phase II open-label trial (NCT04315480) with tocilizumab 8 mg/kg single dose is being conducted in patients with severe multifocal interstitial pneumonia due to COVID-19 to evaluate its role in the virus-induced cytokine storm, in blocking deterioration of lung function or even promoting a rapid improvement of clinical conditions, preventing naso-tracheal intubation and/or death [51] . abstract: At present, there are no proven agents for treatment of coronavirus disease (COVID-19). The available evidence has not allowed guidelines to clearly recommend any drugs outside the context of clinical trials. The novel coronavirus SARS-CoV-2 that causes COVID-19 invokes a hyperinflammatory state driven by multiple cells and mediators like interleukin (IL)-1, IL-6, IL-12, and IL-18, tumor necrosis factor alpha (TNFα), etc. Considering the proven role of cytokine dysregulation in causing this hyperinflammation in the lungs with IL-6 being a key driver, particularly in seriously ill COVID-19 patients, it is crucial to further explore selective cytokine blockade with drugs like the IL-6 inhibitors tocilizumab, sarilumab, and siltuximab. These targeted monoclonal antibodies can dampen the downstream IL-6 signaling pathways, which can lead to decreased cell proliferation, differentiation, oxidative stress, exudation, and improve clinical outcomes in patients with evident features of cytokine-driven inflammation like persistent fever, dyspnea and elevated markers. Preliminary evidence has come for tocilizumab from some small studies, and interim analysis of a randomized controlled trial; the latter also being available for sarilumab. International guidelines do include IL-6 inhibitors as one of the options available for severe or critically ill patients. There has been increased interest in evaluating these drugs with a series of clinical trials being registered and conducted in different countries. The level of investigation though perhaps needs to be further intensified as there is a need to focus on therapeutic options that can prove to be ‘life-saving’ as the number of COVID-19 fatalities worldwide keeps increasing alarmingly. IL-6 inhibitors could be one such treatment option, with generation of more evidence and completion of a larger number of systematic studies. url: https://www.ncbi.nlm.nih.gov/pubmed/32535732/ doi: 10.1007/s40290-020-00342-z id: cord-301800-ssdzd43t author: Atal, Shubham title: Approval of Itolizumab for COVID-19: A Premature Decision or Need of The Hour? date: 2020-10-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Itolizumab is a first-in-class anti-CD6 monoclonal antibody that was initially developed for various cancers and was later developed and approved in India for treatment of moderate to severe chronic plaque psoriasis in 2013. This drug is now being re-purposed for COVID-19. The potential utility of itolizumab in COVID-19, based on its unique mechanism of action in ameliorating cytokine release syndrome (CRS), was proposed first in Cuba with approval of a single-arm clinical trial and expanded access use. Subsequently, a phase II, open-label, randomized, placebo-controlled trial has been conducted in 30 COVID-19 patients in India after receiving regulatory permission. Based on the results, the Indian drug regulatory agency recently approved itolizumab in July 2020 for ‘restricted emergency use’ for the treatment of CRS in moderate to severe acute respiratory distress syndrome (ARDS) due to COVID-19. This has drawn sharp criticism within the scientific community, with the approval being granted on the basis of a relatively small phase II trial, without conduct of a conventional phase III trial, and lacking availability of the claimed supportive real-world evidence in the public domain to date. In a global scenario where finding a successful treatment for COVID-19 is of utmost priority, a biologic agent has been re-purposed and approved with a successfully completed RCT, in a country where cases and mortality due to COVID-19 are growing exponentially. However, instead of welcoming the approval with open arms, many doubts are being raised. This is an issue that needs to be considered and dealt with sensitively, as well as scientifically. url: https://www.ncbi.nlm.nih.gov/pubmed/33048300/ doi: 10.1007/s40259-020-00448-5 id: cord-270327-v4td3zsa author: Atallah, Bassam title: A Marker of Systemic Inflammation or Direct Cardiac Injury: Should Cardiac Troponin Levels be Monitored in COVID-19 Patients? date: 2020-04-29 words: 1691.0 sentences: 95.0 pages: flesch: 47.0 cache: ./cache/cord-270327-v4td3zsa.txt txt: ./txt/cord-270327-v4td3zsa.txt summary: The first and perhaps most significant overlap between COVID-19 and cardiac disease lies in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)''s pathogenicity and virulence. Of this cohort, 19.7% of patients had cardiac injury, accompanied by more comorbidities, and higher levels of C-reactive protein (CRP), procalcitonin, creatine kinasemyocardial band (MB fraction), myoglobin, high-sensitivity troponin I (hs-cTnI), N-terminal pro-B-type natriuretic peptide (NT-proBNP), aspartate aminotransferase (AST) and creatinine. 5 With relation to COVID-19, a meta-analyses of four studies that included a total of 341 patients in China found the values of cTnI to be significantly increased in cases of severe disease (SMD, 25.6 ng/L; 95% CI, 6.8-44.5 ng/L) compared to milder forms. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres. abstract: nan url: https://doi.org/10.1093/ehjqcco/qcaa033 doi: 10.1093/ehjqcco/qcaa033 id: cord-276524-th6eu11h author: Atallah, Bassam title: Thrombotic events following tocilizumab therapy in critically ill COVID-19 patients: a Façade for prognostic markers date: 2020-09-09 words: 2630.0 sentences: 141.0 pages: flesch: 42.0 cache: ./cache/cord-276524-th6eu11h.txt txt: ./txt/cord-276524-th6eu11h.txt summary: His D-dimer was over 6 times the upper limit of normal (ULN) and started on intensified prophylaxis with unfractionated heparin infusion (UFH) 7500 units TID per our COVID anticoagulation protocol [4] . D-dimer was over 6 times ULN on transfer: Patient was directly placed on high intensity thromboprophylaxis with heparin 7500 SC TID and received tocilizumab on second day of admission. Additionally, the fact that thrombotic events continued to be observed despite decrease in inflammatory markers and the proactive anticoagulative approach adopted, raises more questions about the coagulative mechanisms at play in COVID-19, and the appropriate management strategy. Additionally, the fact that thrombotic events continued to be observed despite decrease in inflammatory markers and the proactive anticoagulative approach adopted, raises more questions about the coagulative mechanisms at play in COVID-19, and the appropriate management strategy. abstract: BACKGROUND: Hospitals in the Middle East Gulf region have experienced an influx of COVID-19 patients to their medical wards and intensive care units. The hypercoagulability of these patients has been widely reported on a global scale. However, many of the experimental treatments used to manage the various complications of COVID-19 have not been widely studied in this context. The effect of the current treatment protocols on patients’ diagnostic and prognostic biomarkers may thus impact the validity of the algorithms adopted. CASE PRESENTATION: In this case series, we report four cases of venous thromboembolism and 1 case of arterial thrombotic event, in patients treated with standard or intensified prophylactic doses of unfractionated heparin or low molecular weight heparin at our institution. Tocilizumab has been utilized as an add-on therapy to the standard of care to treat patients with SARS-CoV-2 associated acute respiratory distress syndrome, in order to dampen the hyperinflammatory response. It is imperative to be aware that this drug may be masking the inflammatory markers (e.g. IL6, CRP, fibrinogen, and ferritin), without reducing the risk of thrombotic events in this population, creating instead a façade of an improved prognostic outcome. However, the D-dimer levels remained prognostically reliable in these cases, as they were not affected by the drug and continued to be at the highest level until event occurrence. CONCLUSIONS: In the setting of tocilizumab therapy, traditional prognostic markers of worsening infection and inflammation, and thus potential risk of acute thrombosis, should be weighed carefully as they may not be reliable for prognosis and may create a façade of an improved prognostic outcome insteasd. Additionally, the fact that thrombotic events continued to be observed despite decrease in inflammatory markers and the proactive anticoagulative approach adopted, raises more questions about the coagulative mechanisms at play in COVID-19, and the appropriate management strategy. url: https://doi.org/10.1186/s12959-020-00236-9 doi: 10.1186/s12959-020-00236-9 id: cord-323470-lpeeugdf author: Ates, Omer Faruk title: Thorax magnetic resonance imaging findings in patients with coronavirus disease (COVID-19) date: 2020-08-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: RATIONALE AND OBJECTIVES: The aim of this study was to compare the findings found in thorax computed tomography (CT), which is increasingly used in the diagnosis of the important public health problem of coronavirus disease (COVID-19), and the findings of magnetic resonance imaging (MRI) as an important diagnostic alternative. MATERIALS AND METHODS: Thirty-two patients diagnosed with COVID-19 who underwent thorax CT for COVID pneumonia and MRI for any reason within 24 hours after CT were included in the study. The number of lobes affected, number of lobes containing ground-glass opacities and consolidation, number of nodules, distribution of lesions (central, peripheral or diffuse), lobes with centrilobular nodular pattern, and the presence of pleural effusion were recorded separately for both imaging methods. RESULTS: Seventeen of the patients were female (53%) and 15 were male (47%). The mean age of the patients was 60.5 (range, 20-85) years. A total of 31 patients (96%) had signs of pneumonia on CT. The most common finding in CT was ground-glass opacities in 29 patients (90.6%), followed by consolidation in 14 patients (43.75%). Both consolidation and ground-glass opacities were also observed in MRI in all of these patients. On CT, nodules were detected in 12 patients (37.5%) on CT and 11 patients (34.4%) on MRI. The sensitivity and specificity of MRI in nodule detection were calculated as 91.67% and 100%, respectively. CONCLUSION: Although thorax CT is widely used in the imaging of COVID-19 infection, due to its advantages, MRI can also be used as an alternative diagnostic tool. url: https://api.elsevier.com/content/article/pii/S1076633220304906 doi: 10.1016/j.acra.2020.08.009 id: cord-289054-fh95b5n4 author: Au Yong, Phui S. title: Reducing droplet spread during airway manipulation: lessons from the COVID-19 pandemic in Singapore date: 2020-04-15 words: 1181.0 sentences: 77.0 pages: flesch: 53.0 cache: ./cache/cord-289054-fh95b5n4.txt txt: ./txt/cord-289054-fh95b5n4.txt summary: E-mail: angie.au.yong.p.s@singhealth.com.sg Keywords: airway management; COVID-19; extubation; infection control; intubation; operating room; prevention EditordCoronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization 1 on March 11, 2020 because of its rapid worldwide spread. 2 Airway manipulation poses a high risk of viral transmission to humans within close contact because of the proximity of the respiratory secretions that can aerosolise from coughing and gagging. The Singapore General Hospital instituted guidelines for airborne and contact precautions, including (i) environmental, reducing staff during airway manipulation, regular disinfection and sterilisation, sufficient air exchange time; and (ii) personal protective equipment (PPE). The main aim of constructing a tent or screen is that, if the patient coughs/gags during intubation, secretions will land under the sheet. A videolaryngoscope and tracheal tube can be passed under the plastic tent for intubation. Alternatively, Supplementary Fig 4 shows the use of a large plastic screen for intubation. abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0007091220302191 doi: 10.1016/j.bja.2020.04.007 id: cord-327349-rxb6zfoc author: Au, Lewis title: Cancer, COVID-19, and antiviral immunity: the CAPTURE study date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The SARS-CoV-2 pandemic has posed a significant challenge for risk evaluation and mitigation amongst cancer patients. Susceptibility to and severity of COVID-19 in cancer patients has not been studied in a prospective and broadly applicable manner. CAPTURE is a pan-cancer, longitudinal immune profiling study designed to address this knowledge gap. url: https://api.elsevier.com/content/article/pii/S0092867420311466 doi: 10.1016/j.cell.2020.09.005 id: cord-328607-lzai90zq author: Augoustides, John G. title: Cardiovascular Consequences and Considerations of Coronavirus Infection – Perspectives for the Cardiothoracic Anesthesiologist and Intensivist During the Coronavirus Crisis date: 2020-04-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S1053077020303153 doi: 10.1053/j.jvca.2020.04.001 id: cord-280358-ru2hv6pz author: Auvinen, R. title: Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients: a prospective observational study date: 2020-06-29 words: 4219.0 sentences: 271.0 pages: flesch: 50.0 cache: ./cache/cord-280358-ru2hv6pz.txt txt: ./txt/cord-280358-ru2hv6pz.txt summary: title: Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients: a prospective observational study Objective We compared the clinical characteristics, findings and outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) or influenza to detect relevant differences. Our prospective population-based influenza study was already recruiting hospitalized adult patients with severe acute respiratory infection (SARI), which gave us the opportunity to enroll COVID-19 patients since the beginning of the outbreak. In previous studies, along with age and other comorbidities, obesity has been a risk factor for severe disease and ICU admission in both COVID-19 and influenza, which supports our findings [30, 31] . . https://doi.org/10.1101/2020.06.29.20140632 doi: medRxiv preprint epidemic, occasionally SARS-CoV-2 detection alone was conducted without influenza testing on clinical grounds, however, of the COVID-19 patients included in this study, 21 (75%) were tested for influenza and no co-infections were found. abstract: Objective We compared the clinical characteristics, findings and outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) or influenza to detect relevant differences. Methods From December 2019 to April 2020, we recruited all eligible hospitalized adults with respiratory infection to a prospective observational study at the HUS Jorvi Hospital, Finland. Influenza and SARS-CoV-2 infections were confirmed by RT-PCR. Follow-up lasted for at least 30 days from admission. Results We included 61 patients, of whom 28 were COVID-19 and 33 influenza patients with median ages of 53 and 56 years. Majority of both COVID-19 and influenza patients were men (61% vs 67%) and had at least one comorbidity (68% vs 85%). Pulmonary diseases and current smoking were less common among COVID-19 than influenza patients (5 [18%] vs 15 [45%], P=0.03 and 1 [4%] vs 10 [30%], P=0.008). In chest x-ray at admission, ground-glass opacities and consolidations were more frequent among COVID-19 than influenza patients (19 [68%] and 7 [21%], P < 0.001). Severe disease and intensive care unit (ICU) admission occurred more often among COVID-19 than influenza patients (26 [93%] vs 19 [58%], P=0.003 and 8 [29%] vs 2 [6%], P=0.034). COVID-19 patients were hospitalized longer than influenza patients (6 days [IQR 4-21] vs 3 [2-4], P<0.001). Conclusion Bilateral ground-glass opacities and consolidations in chest X-ray may help to differentiate COVID-19 from influenza. Hospitalized COVID-19 patients had more severe disease, required longer hospitalization and were admitted to ICU more often than influenza patients, which has important implications for public health policies. url: https://doi.org/10.1101/2020.06.29.20140632 doi: 10.1101/2020.06.29.20140632 id: cord-299346-f13xly6q author: Awad, Mohamed E. title: Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed Coronavirus Disease 2019 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current Coronavirus Disease 2019 Pandemic date: 2020-04-10 words: 4216.0 sentences: 254.0 pages: flesch: 42.0 cache: ./cache/cord-299346-f13xly6q.txt txt: ./txt/cord-299346-f13xly6q.txt summary: title: Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed Coronavirus Disease 2019 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current Coronavirus Disease 2019 Pandemic To reduce the occupational risk in treating suspected or confirmed COVID-19 urgent orthopaedic patients, recommended precautions and preventive actions (triage area, ED consultation room, induction room, operating room, and recovery room) are reviewed. HCPs in high-risk areas should adhere to infection prevention and control practices, which includes the appropriate use of engineering controls (negative pressure rooms), administrative controls, and personal protective equipment (PPE) ( 6 Per CDC recommendations, a clinically suspected/ confirmed COVID-19 patient should wear a cloth face covering, over nose, and mouth and a surgical mask should be reserved for HCP and first responders. It is recommended for an environmental services worker to increase the Flowchart demonstrating the the recommended use of personal protective equipment for different activities at various settings managing suspected/clinically Coronavirus disease 2019 patients. abstract: By April 7, 2020, severe acute respiratory syndrome coronavirus 2 was responsible for 1,383,436 confirmed cases of Coronavirus disease 2019 (COVID-19), involving 209 countries around the world; 378,881 cases have been confirmed in the United States. During this pandemic, the urgent surgical requirements will not stop. As an example, the most recent Centers of Disease Control and Prevention reports estimate that there are 2.8 million trauma patients hospitalized in the United States. These data illustrate an increase in the likelihood of encountering urgent surgical patients with either clinically suspected or confirmed COVID-19 in the near future. Preparation for a pandemic involves considering the different levels in the hierarchy of controls and the different phases of the pandemic. Apart from the fact that this pandemic certainly involves many important health, economic, and community ramifications, it also requires several initiatives to mandate what measures are most appropriate to prepare for mitigating the occupational risks. This article provides evidence-based recommendations and measures for the appropriate personal protective equipment for different clinical and surgical activities in various settings. To reduce the occupational risk in treating suspected or confirmed COVID-19 urgent orthopaedic patients, recommended precautions and preventive actions (triage area, ED consultation room, induction room, operating room, and recovery room) are reviewed. url: https://www.ncbi.nlm.nih.gov/pubmed/32282441/ doi: 10.5435/jaaos-d-20-00227 id: cord-275041-fcdwitxy author: Ayerbe, Luis title: The association of treatment with hydroxychloroquine and hospital mortality in COVID-19 patients date: 2020-09-30 words: 3258.0 sentences: 171.0 pages: flesch: 50.0 cache: ./cache/cord-275041-fcdwitxy.txt txt: ./txt/cord-275041-fcdwitxy.txt summary: The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with hydroxychloroquine, azithromycin, heparin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality. Using limited evidence and clinical experience, doctors have treated COVID-19 patients with different drugs to eliminate or reduce the presence of the virus, including hydroxychloroquine (HCQ) [9] [10] [11] [12] . The association between treatment with HCQ and mortality was examined with four different logistic regression models: model one was adjusted for age and gender; model two included age and gender, together with temperature > 37 °C, and saturation of oxygen < 90% on admission, which were both associated with mortality in an exploratory analysis; model three had all the variables previously mentioned together with treatment with azithromycin, steroids, heparin, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir; finally, to account for the change in clinical management during the study period, model four was adjusted for all the previously mentioned demographic, clinical severity measures, and drugs, together with a categorical variable for date of admission (before the 10th of March, 11-20th of March, 20-31st March, 1st-10th of April, and 11-20th of April). abstract: This study investigates the association between the treatment with hydroxychloroquine and mortality in patients admitted with COVID-19. Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with COVID-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were used. The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with hydroxychloroquine, azithromycin, heparin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality. Multivariable logistic regression models were used to investigate the associations. At the time of collecting the data, 301 patients had died, 1449 had been discharged home from the hospitals, 240 were still admitted, and 85 had been transferred to hospitals not included in the study. Median follow-up time was 8 (IQR 5–12) days. Hydroxychloroquine had been used in 1857 patients. Hydroxychloroquine was associated with lower mortality when the model was adjusted for age and gender, with OR (95% CI): 0.44 (0.29–0.67). This association remained significant when saturation of oxygen < 90% and temperature > 37 °C were added to de model with OR 0.45 (0.30–0.68) p < 0.001, and also when all the other drugs, and time of admission, were included as covariates. The association between hydroxychloroquine and lower mortality observed in this study can be acknowledged by clinicians in hospitals and in the community. Randomized-controlled trials to assess the causal effects of hydroxychloroquine in different therapeutic regimes are required. url: https://www.ncbi.nlm.nih.gov/pubmed/32997237/ doi: 10.1007/s11739-020-02505-x id: cord-311970-o9xao5rl author: Ayerbe, Luis title: The association between treatment with heparin and survival in patients with Covid-19 date: 2020-05-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19. Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with Covid-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were used. The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with heparin, hydroxychloroquine, azithromycin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality. Multivariable logistic regression models were used to investigate the associations. At the time of collecting the data, 301 patients had died, 1447 had been discharged home from the hospitals, 201 were still admitted, and 126 had been transferred to hospitals not included in the study. Median follow up time was 8 (IQR 5–12) days. Heparin had been used in 1734 patients. Heparin was associated with lower mortality when the model was adjusted for age and gender, with OR (95% CI) 0.55 (0.37–0.82) p = 0.003. This association remained significant when saturation of oxygen < 90%, and temperature > 37 °C were added to de model with OR 0.54 (0.36–0.82) p = 0.003, and also when all the other drugs were included as covariates OR 0.42 (0.26–0.66) p < 0.001. The association between heparin and lower mortality observed in this study can be acknowledged by clinicians in hospitals and in the community. Randomized controlled trials to assess the causal effects of heparin in different therapeutic regimes are required. url: https://www.ncbi.nlm.nih.gov/pubmed/32476080/ doi: 10.1007/s11239-020-02162-z id: cord-280070-c1bkhgaz author: Azadeh, Natalya title: The Role of Infection in Interstitial Lung Diseases A Review date: 2017-10-31 words: 6524.0 sentences: 399.0 pages: flesch: 40.0 cache: ./cache/cord-280070-c1bkhgaz.txt txt: ./txt/cord-280070-c1bkhgaz.txt summary: Prognosis can vary according to the type of ILD, but many exhibit gradual progression with an unpredictable clinical course in individual patients, as seen in idiopathic pulmonary fibrosis and the phenomenon of "acute exacerbation"(AE). Diagnostic evaluations of patients with suspected ILD also need to consider infections, since they can cause various histopathologic patterns commonly associated with ILDs including NSIP, LIP, organizing pneumonia, and eosinophilic pneumonia, among others (Table 1) . Richter et al 19 19 It is currently difficult to determine whether patients with IPF are more susceptible to infection or colonization due to abnormal lung parenchyma, associated traction bronchiectasis, and immunosuppressive medications (which historically have been commonly used for treatment of ILDs), or whether bacteria are involved as triggers of AE or in the pathogenesis of IPF. Histopathologic features and outcome of patients with acute exacerbation of idiopathic pulmonary fibrosis undergoing surgical lung biopsy Acute exacerbation of idiopathic pulmonary fibrosis: role of Chlamydophila pneumoniae infection abstract: Interstitial lung disease (ILD) comprises an array of heterogeneous parenchymal lung diseases that are associated with a spectrum of pathologic, radiologic, and clinical manifestations. There are ILDs with known causes and those that are idiopathic, making treatment strategies challenging. Prognosis can vary according to the type of ILD, but many exhibit gradual progression with an unpredictable clinical course in individual patients, as seen in idiopathic pulmonary fibrosis and the phenomenon of “acute exacerbation”(AE). Given the often poor prognosis of these patients, the search for a reversible cause of respiratory worsening remains paramount. Infections have been theorized to play a role in ILDs, both in the pathogenesis of ILD and as potential triggers of AE. Research efforts thus far have shown the highest association with viral pathogens; however, fungal and bacterial organisms have also been implicated. This review aims to summarize the current knowledge on the role of infections in the setting of ILD. url: https://doi.org/10.1016/j.chest.2017.03.033 doi: 10.1016/j.chest.2017.03.033 id: cord-355039-qi4fwqbc author: Azar, William S. title: COVID-19 and diabetes mellitus: how one pandemic worsens the other date: 2020-08-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In light of the most challenging public health crisis of modern history, COVID-19 mortality continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, cardiovascular disease, and diabetes mellitus (DM) seem to be more prone to severe symptoms and appear to have a higher mortality rate. In this review, we elucidate suggested mechanisms underlying the increased susceptibility of patients with diabetes to infection with SARS-CoV-2 with a more severe COVID-19 disease. The worsened prognosis of COVID-19 patients with DM can be attributed to a facilitated viral uptake assisted by the host’s receptor angiotensin-converting enzyme 2 (ACE2). It can also be associated with a higher basal level of pro-inflammatory cytokines present in patients with diabetes, which enables a hyperinflammatory “cytokine storm” in response to the virus. This review also suggests a link between elevated levels of IL-6 and AMPK/mTOR signaling pathway and their role in exacerbating diabetes-induced complications and insulin resistance. If further studied, these findings could help identify novel therapeutic intervention strategies for patients with diabetes comorbid with COVID-19. url: https://doi.org/10.1007/s11154-020-09573-6 doi: 10.1007/s11154-020-09573-6 id: cord-342569-ja96xfns author: Azer, Samy A. title: COVID-19: Pathophysiology, diagnosis, complications and Investigational therapeutics date: 2020-08-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The novel coronavirus (COVID-19) outbreak started early in December 2019 in the Hubei province and its capital Wuhan of the People’s Republic of China and caused a global pandemic. The number of patients confined to this disease has exceeded nine million in more than 215 countries, and the number who died is over 480,600 (up to 25 June 2020). Coronaviruses were identified in the 1960s and recently identified to cause the Middle East Respiratory Syndrome (MERS-CoV) in 2012 and severe acute respiratory syndrome (SARS) in 2003. The current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the most recently identified. Patients with COVID-19 may be asymptomatic. Typical symptoms including fever, dry cough, and shortness of breath. Gastrointestinal symptoms such as nausea, vomiting, abdominal pain and diarrhea, have been reported—neurologically related symptoms, particularly anosmia, hyposmia, and dysgeusia, have also been reported. Physical examination may reveal a fever in over 44% of patients (and could be documented in over 88% of patients after admission), increased respiratory rate, acute respiratory disease, and maybe decreased consciousness, agitation, and confusion. This article aims at presenting an up-to-date review on the pathogenesis, diagnosis and complications of COVID-19 infection. Currently, no therapeutics have been found to be effective. Investigational therapeutics are briefly discussed. url: https://api.elsevier.com/content/article/pii/S2052297520300901 doi: 10.1016/j.nmni.2020.100738 id: cord-297870-m7n43k4p author: Azevedo, Rafael Bellotti title: Covid-19 and the cardiovascular system: a comprehensive review date: 2020-07-27 words: 5108.0 sentences: 211.0 pages: flesch: 30.0 cache: ./cache/cord-297870-m7n43k4p.txt txt: ./txt/cord-297870-m7n43k4p.txt summary: Moreover, as in other respiratory infections, preexisting CV diseases and risk factors can increase the severity of COVID-19, leading to the aggravation and decompensation of chronic underlying cardiac pathologies as well as acute-onset of new cardiac complications [3] , highlighting that myocardial injury can be present in approximately 12% of hospitalized patients with SARS-CoV-2 infection [1] . Within the CV manifestations of COVID-19, we can highlight four different aspects: (a) CV risk factors and established CV disease is associated with a worse prognosis, (b) appearance of acute CV complications in previously healthy individuals, (c) promising therapies with antimalarials and antivirals present important CV side effects, and (d) questioning the safety of the use of renin-angiotensin-aldosterone system (RAAS) inhibitors regarding an increased risk of COVID-19 [1] . abstract: Cardiac injury in patients infected with the novel Coronavirus (COVID-19) seems to be associated with higher morbimortality. We provide a broad review of the clinical evolution of COVID-19, emphasizing its impact and implications on the cardiovascular system. The pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by overproduction of inflammatory cytokines (IL-6 and TNF-α) leading to systemic inflammation and multiple organ dysfunction syndrome, acutely affecting the cardiovascular system. Hypertension (56.6%) and diabetes (33.8%) are the most prevalent comorbidities among individuals with COVID-19, who require hospitalization. Furthermore, cardiac injury, defined as elevated us-troponin I, significantly relates to inflammation biomarkers (IL-6 and C-reactive protein (CRP), hyperferritinemia, and leukocytosis), portraying an important correlation between myocardial injury and inflammatory hyperactivity triggered by viral infection. Increased risk for myocardial infarction, fulminant myocarditis rapidly evolving with depressed systolic left ventricle function, arrhythmias, venous thromboembolism, and cardiomyopathies mimicking STEMI presentations are the most prevalent cardiovascular complications described in patients with COVID-19. Moreover, SARS-CoV-2 tropism and interaction with the RAAS system, through ACE2 receptor, possibly enhances inflammation response and cardiac aggression, leading to imperative concerns about the use of ACEi and ARBs in infected patients. Cardiovascular implications result in a worse prognosis in patients with COVID-19, emphasizing the importance of precocious detection and implementation of optimal therapeutic strategies. url: https://www.ncbi.nlm.nih.gov/pubmed/32719447/ doi: 10.1038/s41371-020-0387-4 id: cord-344185-jz6ui4w3 author: Aziz, Aleha title: Building an Obstetric Intensive Care Unit during the COVID-19 Pandemic at a Tertiary Hospital and Selected Maternal-Fetal and Delivery Considerations date: 2020-07-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: During the novel Coronavirus Disease 2019 pandemic, New York City became an international epicenter for this highly infectious respiratory virus. In anticipation of the unfortunate reality of community spread and high disease burden, the Anesthesia and Obstetrics and Gynecology departments at NewYork-Presbyterian / Columbia University Irving Medical Center, an academic hospital system in Manhattan, created an Obstetric Intensive Care Unit on Labor and Delivery to defray volume from the hospital's preexisting intensive care units. Its purpose was threefold: (1) to accommodate the anticipated influx of critically ill pregnant and postpartum patients due to novel coronavirus, (2) to care for critically ill obstetric patients who would previously have been transferred to a non-obstetric intensive care unit, and (3) to continue caring for our usual census of pregnant and postpartum patients, who are novel Coronavirus negative and require a higher level of care. In this chapter, we share key operational details for the conversion of a non-intensive care space into an obstetric intensive care unit, with an emphasis on the infrastructure, personnel and workflow, as well as the goals for maternal and fetal monitoring. url: https://api.elsevier.com/content/article/pii/S0146000520300811 doi: 10.1016/j.semperi.2020.151298 id: cord-332153-fczf3lzc author: Azkur, Ahmet Kursat title: Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19 date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As a zoonotic disease that has already spread globally to several million human beings and possibly to domestic and wild animals, eradication of coronavirus disease 2019 (COVID‐19) appears practically impossible. There is a pressing need to improve our understanding of the immunology of this disease to contain the pandemic by developing vaccines and medicines for the prevention and treatment of patients. In this review, we aim to improve our understanding on the immune response and immunopathological changes in patients linked to detoriating clinical conditions such as, cytokine storm, acute respiratory distress syndrome, autopsy findings and changes in acute phase reactants and serum biochemistry in COVID‐19. Similar to many other viral infections, asymptomatic disease is present in a significant but currently unknown fraction of the affected individuals.In the majority of the patients, a one‐week, self‐limiting viral respiratory disease typically occurs, which ends with the development of neutralizing anti‐viral T cell and antibody immunity. The IgM, IgA and IgG type virus‐specific antibodies levels are important measurements to predict population immunity against this disease and whether cross‐reactivity with other coronaviruses is taking place.High viral‐load during the first infection and repeated exposure to virus especially in healthcare workers can be an important factor for severity of disease. It should be noted that many aspects of severe patients are unique to COVID‐19 and are rarely observed in other respiratory viral infections, such as severe lymphopenia and eosinopenia, extensive pneumonia and lung tissue damage, a cytokine storm leading to acute respiratory distress syndrome and multiorgan failure. Lymphopenia causes a defect in antiviral and immune regulatory immunity. At the same time, a cytokine storm starts with extensive activation of cytokine‐secreting cells with innate and adaptive immune mechanisms both of with contribute to a poor prognosis. Elevated levels of acute phase reactants and lymphopenia are early predictors of high disease severity. Prevention of development to severe disease, cytokine storm, acute respiratory distress syndrome and novel approachs to prevent their development will be main routes for future research areas. As we learn to live amidst the virus, understanding the immunology of the disease can assist in containing the pandemic and in developing vaccines and medicines to prevent and treat individual patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32396996/ doi: 10.1111/all.14364 id: cord-335802-1kiqfy68 author: Azoulay, Elie title: Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Coronavirus disease 2019 (COVID-19) is creating an unprecedented healthcare crisis. Understanding the determinants of mortality is crucial to optimise intensive care unit (ICU) resource use and to identify targets for improving survival. METHODS: In a multicentre retrospective study, we included 379 COVID-19 patients admitted to four ICUs between 20 February and 24 April 2020 and categorised according to time from disease onset to ICU admission. A Cox proportional-hazards model identified factors associated with 28-day mortality. RESULTS: Median age was 66 years (53–68) and 292 (77%) were men. The main comorbidities included obesity and overweight (67%), hypertension (49.6%) and diabetes (30.1%). Median time from disease onset (i.e., viral symptoms) to ICU admission was 8 (6–11) days (missing for three); 161 (42.5%) patients were admitted within a week of disease onset, 173 (45.6%) between 8 and 14 days, and 42 (11.1%) > 14 days after disease onset; day 28 mortality was 26.4% (22–31) and decreased as time from disease onset to ICU admission increased, from 37 to 21% and 12%, respectively. Patients admitted within the first week had higher SOFA scores, more often had thrombocytopenia or acute kidney injury, had more limited radiographic involvement, and had significantly higher blood IL-6 levels. Age, COPD, immunocompromised status, time from disease onset, troponin concentration, and acute kidney injury were independently associated with mortality. CONCLUSION: The excess mortality in patients admitted within a week of disease onset reflected greater non-respiratory severity. Therapeutic interventions against SARS-CoV-2 might impact different clinical endpoints according to time since disease onset. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-020-06202-3) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32780165/ doi: 10.1007/s00134-020-06202-3 id: cord-317535-zep5axfo author: Azpiazu Landa, N. title: Ischemic-hemorrhagic stroke in patients with Covid-19 date: 2020-11-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus associated severe acute respiratory syndrome (SARS-CoV-2) causes a worldwide syndrome called Covid-19 that has caused 5,940,441 infections and 362,813 deaths until May 2020. In moderate and severe stages of the infection a generalized swelling, cytokine storm and an increment of the heart damage biomarkers occur. In addition, a relation between Covid-19 and neurological symptoms have been suggested. The results of autopsies suggest thrombotic microangiopathy in multiple organs. We present 2 cases of patients infected with severe Covid-19 that were hospitalized in the Reanimation Unit that presented cerebrovascular symptoms and died afterwards. A high dose prophylaxis with antithrombotic medication is recommended in patients affected by moderate to severe Covid-19. url: https://api.elsevier.com/content/article/pii/S234119292030144X doi: 10.1016/j.redare.2020.08.001 id: cord-257732-3xuy6tbn author: Azzi, Lorenzo title: Saliva is a reliable tool to detect SARS-CoV-2 date: 2020-04-14 words: 3510.0 sentences: 201.0 pages: flesch: 56.0 cache: ./cache/cord-257732-3xuy6tbn.txt txt: ./txt/cord-257732-3xuy6tbn.txt summary: OBJECTIVES: This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data. At present, Real Time reverse transcription Polymerase Chain Reaction (rRT-PCR) on respiratory specimens represents the gold standard test for detection of SARS-CoV-2 infection. 10 , 11 Sputum and oropharyngeal secretions have recently been suggested as a possible target for the molecular diagnosis of COVID-19, 12 and salivary droplets represent the main source of the human-to-human transmission of the SARS-CoV-2 infection when social distance is less than 2 m. There were not significant differences regarding the clinical and anamnestic history between males and females, with the only exception of the values of serum LDH, which were higher in the female patients'' haematochemical analyses carried out on the day of saliva collection ( p = 0.025). abstract: OBJECTIVES: This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data. METHODS: Salivary samples of 25 COVID-19 patients were analyzed by rRT-PCR. The following data were collected: age, sex, comorbidities, drugs. Lactate dehydrogenase (LDH) and ultrasensitive reactive C protein (usRCP) values were registered on the same day when a salivary swab was collected. Prevalence of positivity in saliva and association between clinical data and the cycle threshold as a semiquantitative indicator of viral load were considered. RESULTS: Twenty-five subjects were recruited into this study, 17 males and 8 females. The mean age was 61.5 +/− 11.2 years. Cardiovascular and/or dysmetabolic disorders were observed in 65.22% of cases. All the samples tested positive for the presence of SARS-CoV-2, while there was an inverse association between LDH and Ct values. Two patients showed positive salivary results on the same days when their pharyngeal or respiratory swabs showed conversion. CONCLUSIONS: Saliva is a reliable tool to detect SARS-CoV-2. The role of saliva in COVID-19 diagnosis could not be limited to a qualitative detection of the virus, but it may also provide information about the clinical evolution of the disease. url: https://www.ncbi.nlm.nih.gov/pubmed/32298676/ doi: 10.1016/j.jinf.2020.04.005 id: cord-306108-ja0wyr5w author: B K, Anupama title: A Review of Acute Myocardial Injury in Coronavirus Disease 2019 date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In December 2019, an outbreak of pneumonia caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan, Hubei province, China, and it has spread rapidly across the world, causing the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 infection predominantly results in pulmonary issues, accumulating evidence suggests the increased frequency of a variety of cardiovascular complications in patients with COVID-19. Acute cardiac injury, defined as elevated cardiac troponin levels, is the most reported cardiac abnormality in COVID-19 and strongly associated with mortality. In this article, we summarize the currently available data on the association of SARS-CoV-2 and COVID-19 with acute myocardial injury. url: https://www.ncbi.nlm.nih.gov/pubmed/32642342/ doi: 10.7759/cureus.8426 id: cord-266429-0xaz8kbs author: Bader, Feras title: Heart failure and COVID-19 date: 2020-07-27 words: 5003.0 sentences: 223.0 pages: flesch: 37.0 cache: ./cache/cord-266429-0xaz8kbs.txt txt: ./txt/cord-266429-0xaz8kbs.txt summary: A more recent large global observational study that included 169 hospitals from three continents and close to 9000 patients found coronary artery disease and congestive heart failure (mortality of 15.3%, vs. Pressure guide, physician-directed, patient self-management has been previously shown to not only reduce heart failure related hospitalizations but also lead to higher frequency of medication adjustments including neurohormonal antagonists [59] . When infected by the virus, immunosuppression may influence the typical clinical presentation of COVID-19 patients who are also heart transplant recipients, resulting in unusual symptoms such as gastrointestinal manifestations [65] . Reported cases from a European transplantation center showed that solid organ recipients with COVID-19 had a more severe clinical course and high complications rates when compared with the general populations [65] . Considerations for heart failure care during the coronavirus disease 2019 (COVID-19) pandemic. Association of renin-angiotensin system inhibitors with severity or risk of death in patients with hypertension hospitalized for coronavirus disease 2019 (COVID-19) infection in Wuhan, China abstract: Heart failure is a common disease state that can be encountered at different stages in the course of a COVID-19 patient presentation. New or existing heart failure in the setting of COVID-19 can present a set of unique challenges that can complicate presentation, management, and prognosis. A careful understanding of the hemodynamic and diagnostic implications is essential for appropriate triage and management of these patients. Abnormal cardiac biomarkers are common in COVID-19 and can stem from a variety of mechanisms that involve the viral entry itself through the ACE2 receptors, direct cardiac injury, increased thrombotic activity, stress cardiomyopathy, and among others. The cytokine storm observed in this pandemic can be a culprit in many of the observed mechanisms and presentations. A correct understanding of the two-way interaction between heart failure medications and the infection as well as the proposed COVID-19 medications and heart failure can result in optimal management. Guideline-directed medical therapy for heart failure should not be interrupted for theoretical concerns but rather based on tolerance and clinical presentation. Initiating specific cardiac or heart failure medications to prevent the infection or mitigate the disease is also not an evidence-based practice at this time. Heart failure patients on advanced therapies including those with heart transplantation will particularly benefit from involving the advanced heart failure team members in the overall management if they contract the virus. url: https://www.ncbi.nlm.nih.gov/pubmed/32720082/ doi: 10.1007/s10741-020-10008-2 id: cord-294788-9usyb1nn author: Baek, Woong Kee title: A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 date: 2020-05-03 words: 4459.0 sentences: 231.0 pages: flesch: 46.0 cache: ./cache/cord-294788-9usyb1nn.txt txt: ./txt/cord-294788-9usyb1nn.txt summary: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the virus strain that causes coronavirus disease 2019 (COVID-19), was first identified in Wuhan, China in December 2019. It is suspected that the acute respiratory distress syndrome (ARDS)-like picture in SARS-CoV-2-infected patients is precipitated and worsened by the excess monocytes in response to GM-CSF, which is released by rapidly activated CD4+T-cell lineage [17] . have reported that the cytokine profile and the trend of the inflammatory markers of SARS-CoV-2-infected patients present similarly to the secondary hemophagocytic lymphohistiocytosis (sHLH), whose severe clinical presentation is related to the cytokine storm [23] . There is no consensus yet on how to treat SARS-CoV-2-infected patients who present with a wide spectrum of clinical symptoms and severity. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Epub ahead of print) abstract: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the virus strain that causes coronavirus disease 2019 (COVID-19), was first identified in Wuhan, China in December 2019. It spread to several countries across continents and infected more than one million people within three months. While there is no consensus on the treatment of the disease yet, understanding the virus and its transmission is a cardinal priority. SARS-CoV-2 can be transmitted through bodily fluid. Upon inoculation, the surface enzyme angiotensin-converting enzyme 2 (ACE2) acts as a receptor protein for viral entry. The mean incubation period is 5.1 days, and infected individuals can exhibit a variety of symptoms from fever, cough, dyspnea, and respiratory failure to even multiorgan failure. Given the current situation, it is of paramount importance to understand the virus as thoroughly as possible. In this review, we discuss the background, epidemiology, possible pathophysiology, clinical presentation, and diagnostic studies related to SARS-CoV-2 infection. We also elaborate on the current research and evidence on treatment options and vaccine development based on the literature. url: https://doi.org/10.7759/cureus.7943 doi: 10.7759/cureus.7943 id: cord-328569-1lx3fkv3 author: Bagate, François title: Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: In COVID-19 patients with severe acute respiratory distress syndrome (ARDS), the relatively preserved respiratory system compliance despite severe hypoxemia, with specific pulmonary vascular dysfunction, suggests a possible hemodynamic mechanism for VA/Q mismatch, as hypoxic vasoconstriction alteration. This study aimed to evaluate the capacity of inhaled nitric oxide (iNO)–almitrine combination to restore oxygenation in severe COVID-19 ARDS (C-ARDS) patients. METHODS: We conducted a monocentric preliminary pilot study in intubated patients with severe C-ARDS. Respiratory mechanics was assessed after a prone session. Then, patients received iNO (10 ppm) alone and in association with almitrine (10 μg/kg/min) during 30 min in each step. Echocardiographic and blood gases measurements were performed at baseline, during iNO alone, and iNO–almitrine combination. The primary endpoint was the variation of oxygenation (PaO(2)/FiO(2) ratio). RESULTS: Ten severe C-ARDS patients were assessed (7 males and 3 females), with a median age of 60 [52–72] years. Combination of iNO and almitrine outperformed iNO alone for oxygenation improvement. The median of PaO(2)/FiO(2) ratio varied from 102 [89–134] mmHg at baseline, to 124 [108–146] mmHg after iNO (p = 0.13) and 180 [132–206] mmHg after iNO and almitrine (p < 0.01). We found no correlation between the increase in oxygenation caused by iNO–almitrine combination and that caused by proning. CONCLUSION: In this pilot study of severe C-ARDS patients, iNO–almitrine combination was associated with rapid and significant improvement of oxygenation. These findings highlight the role of pulmonary vascular function in COVID-19 pathophysiology. url: https://www.ncbi.nlm.nih.gov/pubmed/33150525/ doi: 10.1186/s13613-020-00769-2 id: cord-350578-wyz5jyjh author: Bai, Li title: Chinese experts’ consensus on the Internet of Things-aided diagnosis and treatment of coronavirus disease 2019 (COVID-19) date: 2020-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The aim is to diagnose COVID-19 earlier and to improve its treatment by applying medical technology, the “COVID-19 Intelligent Diagnosis and Treatment Assistant Program (nCapp)” based on the Internet of Things. Terminal eight functions can be implemented in real-time online communication with the “cloud” through the page selection key. According to existing data, questionnaires, and check results, the diagnosis is automatically generated as confirmed, suspected, or suspicious of 2019 novel coronavirus (2019-nCoV) infection. It classifies patients into mild, moderate, severe or critical pneumonia. nCapp can also establish an online COVID-19 real-time update database, and it updates the model of diagnosis in real time based on the latest real-world case data to improve diagnostic accuracy. Additionally, nCapp can guide treatment. Front-line physicians, experts, and managers are linked to perform consultation and prevention. nCapp also contributes to the long-term follow-up of patients with COVID-19. The ultimate goal is to enable different levels of COVID-19 diagnosis and treatment among different doctors from different hospitals to upgrade to the national and international through the intelligent assistance of the nCapp system. In this way, we can block disease transmission, avoid physician infection, and epidemic prevention and control as soon as possible. url: https://api.elsevier.com/content/article/pii/S2588914120300046 doi: 10.1016/j.ceh.2020.03.001 id: cord-282151-mai4eggf author: Bai, Lu title: Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China date: 2015-12-16 words: 3752.0 sentences: 250.0 pages: flesch: 57.0 cache: ./cache/cord-282151-mai4eggf.txt txt: ./txt/cord-282151-mai4eggf.txt summary: METHODS: During October 26, 2009, and January 23, 2010, adult patients with pneumonia with laboratory-confirmed or clinically suspected A(H1N1) infections were observed for clinical characteristics, high-resolution chest CT scan, and lung function test changes during acute and 3-month convalescent phases. Multivariate Cox regression identified two independent risk factors for death: progressive dyspnea after resolution of fever (relative risk, 5.852; 95% CI, 1.395-24.541; P = .016) and a higher APACHE (Acute Physiology and Chronic Health Evaluation) II score on presentation (relative risk for each point, 1.312; 95% CI, 1.140-1.511; P < .001). 6 Many studies have been published on the clinical manifestations of A(H1N1) pneumonia during the acute phase of illness, [7] [8] [9] [10] [11] [12] [13] [14] [15] but no information has been reported on symptoms and radiographic and lung function changes in convalescence. Information recorded included demographic data, underlying medical conditions, symptoms, signs, laboratory and chest radiograph fi ndings before therapy and during follow-up, and the clinical course, treatment, and adverse events during hospital stay. abstract: BACKGROUND: Data on symptoms and radiographic changes in patients with pandemic 2009 influenza A(H1N1) (A[H1N1]) pneumonia during convalescence have not been reported. METHODS: During October 26, 2009, and January 23, 2010, adult patients with pneumonia with laboratory-confirmed or clinically suspected A(H1N1) infections were observed for clinical characteristics, high-resolution chest CT scan, and lung function test changes during acute and 3-month convalescent phases. RESULTS: Of the 65 case subjects, the median age was 41 (interquartile range [IQR], 28-57) years, 60.0% were men, and 55.4% had at least one underlying medical condition. Sixty-two patients started oseltamivir therapy within a median of 5 (IQR, 4-6) days from the onset of illness, and 31 received IV corticosteroids. ARDS developed in 33 patients, and 24 were treated initially with noninvasive positive pressure ventilation (NPPV). In this group, NPPV was successful in 13 patients (54.2%). Nine patients died at a median of 16 (IQR, 10-24) days after onset of illness. Multivariate Cox regression identified two independent risk factors for death: progressive dyspnea after resolution of fever (relative risk, 5.852; 95% CI, 1.395-24.541; P = .016) and a higher APACHE (Acute Physiology and Chronic Health Evaluation) II score on presentation (relative risk for each point, 1.312; 95% CI, 1.140-1.511; P < .001). At 3-month follow-up of survivors with A(H1N1), ground-glass opacities were still present, although diminished, in 85.7%, and diffusing capacity for carbon monoxide was mildly reduced in 61.5%. CONCLUSIONS: Ground-glass opacities and decreased diffusing capacity were the main abnormalities observed at 3-month follow-up of survivors of A(H1N1). url: https://www.sciencedirect.com/science/article/pii/S0012369211602419 doi: 10.1378/chest.10-1036 id: cord-318229-29cgwivt author: Baier, Claas title: Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease date: 2018-02-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Respiratory syncytial virus (RSV) is responsible for upper and lower respiratory tract infection in adults and children. Especially immunocompromised patients are at high risk for a severe course of infection, and mortality is increased. Moreover RSV can spread in healthcare settings and can cause outbreaks. Herein we demonstrate the successful control and characteristics of a RSV outbreak that included 8 patients in our Department of Pediatric Hematology and Oncology. METHODS: We performed an epidemiologic investigation and a molecular analysis of the outbreak strains. Moreover we present the outbreak control bundle and our concept for RSV screening in the winter season. RESULTS: RSV A and B strains caused the outbreak. RSV B strains affected 3 patients, 2 of whom were co-infected with RSV A. Exactly this RSV A strain was detected in another 5 patients. Our multimodal infection control bundle including prophylactic RSV screening was able to rapidly stop the outbreak. CONCLUSION: An infection control bundle in RSV outbreaks should address all potential transmission pathways. In pediatric settings the restriction of social activities might have a temporal negative impact on quality of life but helps to limit transmission opportunities. Molecular analysis allows better understanding of RSV outbreaks and, if done in a timely manner, might be helpful for guidance of infection control measures. url: https://www.ncbi.nlm.nih.gov/pubmed/29449938/ doi: 10.1186/s13756-018-0316-2 id: cord-328525-80xk3gln author: Baier, Claas title: Influenza and respiratory syncytial virus screening for the detection of asymptomatically infected patients in hematology and oncology date: 2018-09-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction: Respiratory syncytial virus (RSV) and influenza virus infections are a significant healthcare risk for immunocompromised patients. In addition to community onset, nosocomial acquisition and transmission may also occur. Detection of asymptomatic shedders (e.g., patients in the incubation period or immunosuppressed long term shedders) facilitates control of nosocomial transmission. Methods: To strengthen the existing infection control concept, a PCR-based screening for RSV and influenza virus was implemented for all patients lacking respiratory symptoms (asymptomatic patients) who were hospitalized on an adult and a pediatric hemato-oncological ward. Laboratory results of this screening were analyzed retrospectively. Results: 665 respiratory specimens were obtained for screening from 251 patients (26% were 18 years and younger) from December 2016 to April 2017. In 23 patients without respiratory symptoms, either influenza virus or RSV infection was found, resulting in a detection rate of about 9%. In 6 patients, the infection was presumably detected during the incubation period, because an increase of viral load was observed in subsequent specimens. Positive screening results facilitated timely implementation of adequate infection control precautions. Nosocomial clusters of RSV or influenza were not detected during the screening period on the two wards. Conclusion: The seasonal screening program expanded our existing infection control concept in terms of patients lacking respiratory symptoms who shed influenza virus or RSV. It enabled us to identify 23 RSV or influenza infections in patients lacking respiratory symptoms in a 4-month period and thus to rapidly take isolation precautions. url: https://doi.org/10.3205/dgkh000314 doi: 10.3205/dgkh000314 id: cord-104404-ytszpa4c author: Baig, Muhammad Akbar title: The COVID-19 Intubation and Ventilation Pathway (CiVP); a Commentary date: 2020-03-25 words: 654.0 sentences: 49.0 pages: flesch: 50.0 cache: ./cache/cord-104404-ytszpa4c.txt txt: ./txt/cord-104404-ytszpa4c.txt summary: authors: Baig, Muhammad Akbar In wake of the current COVID-19 pandemic, which has taken the world by storm, it is imperative to protect the health and safety of physicians and staff involved in acute management of COVID-19 patients. As of now, it is essential to contain a crashing suspected/confirmed COVID-19 patient within the confines of a negative isolation chamber due to a high risk of aerosolization, with strict adherence to personal protective equipment (PPE), exclusively comprising of N95 or preferably a powered air purifying respirator (PAPR) (1). The ARDSnet (acute respiratory distress syndrome network) protocol should be followed for patient ventilation. Following intubation and initial ventilation, immediately proceed to transfer the patient to intensive care unit, after which, perform decontamination of the initial zone and the equipment used. Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease Prone Positioning in Severe Acute Respiratory Distress Syndrome abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096723/ doi: nan id: cord-035396-lg7m9xzs author: Bains, Amarpreet S. title: Maintaining Throughput and Reducing Discharge Delays After Increasing Capacity During The Covid-19 Pandemic: A New York City Hospital’s Experience date: 2020-11-12 words: 2401.0 sentences: 105.0 pages: flesch: 49.0 cache: ./cache/cord-035396-lg7m9xzs.txt txt: ./txt/cord-035396-lg7m9xzs.txt summary: A command center for coordinating discharges and a streamlined process for arranging home oxygen helped a New York hospital significantly speed up discharges during the Covid-19 pandemic with no negative impact on readmissions. Our second step was to have our Social Work and Case Management departments work closely with our largest DME vendor (who provides over 90% of all oxygen and medical equipment for our patients) to streamline the process for discharging patients home with supplemental oxygen, a process that has historically extended hospitalizations by an entire day or more. We attribute this improvement to: better communication between unit managers and discharge control center; earlier identification of barriers; on-site representative for home oxygen; streamlining of the documentation and authorization processes; providers learning how to optimize documentation; and time saved by many patients not requiring home delivery. abstract: A command center for coordinating discharges and a streamlined process for arranging home oxygen helped a New York hospital significantly speed up discharges during the Covid-19 pandemic with no negative impact on readmissions. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660556/ doi: 10.1056/cat.20.0425 id: cord-266160-464v4g8o author: Bajaj, Jasmohan S title: Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort date: 2020-07-13 words: 3689.0 sentences: 198.0 pages: flesch: 49.0 cache: ./cache/cord-266160-464v4g8o.txt txt: ./txt/cord-266160-464v4g8o.txt summary: COVID-19 and cirrhosis characteristics, development of organ failures and acute-on-chronic liver failure (ACLF) and mortality (inpatient death+hospice) were compared. Patients with cirrhosis alone had higher cirrhosis-related complications, maximum model for end-stage liver disease (MELD) score and lower BiPAP/ventilation requirement compared with patients with cirrhosis+COVID-19, but CCI and ACLF rates were similar. CONCLUSIONS: In this multicentre North American contemporaneously enrolled study, age/gender-matched patients with cirrhosis+COVID-19 had similar mortality compared with patients with cirrhosis alone but higher than patients with COVID-19 alone. Cirrhosis-alone patients had higher rates of grade III/IV HE, developed a higher model for end-stage liver disease (MELD) score and required more endoscopic procedures, including variceal banding, and large-volume paracentesis, than the cirrhosis+COVID-19 group. We conclude in this multicentre study that patients hospitalised with COVID-19 in the setting of cirrhosis have an inpatient mortality rate that is similar to that of patients admitted due to cirrhosis alone but higher than those admitted with COVID-19 without cirrhosis. abstract: OBJECTIVE: Comorbid conditions are associated with poor prognosis in COVID-19. Registry data show that patients with cirrhosis may be at high risk. However, outcome comparisons among patients with cirrhosis+COVID-19 versus patients with COVID-19 alone and cirrhosis alone are lacking. The aim of this study was to perform these comparisons. DESIGN: A multicentre study of inpatients with cirrhosis+COVID-19 compared with age/gender-matched patients with COVID-19 alone and cirrhosis alone was performed. COVID-19 and cirrhosis characteristics, development of organ failures and acute-on-chronic liver failure (ACLF) and mortality (inpatient death+hospice) were compared. RESULTS: 37 patients with cirrhosis+COVID-19 were matched with 108 patients with COVID-19 and 127 patients with cirrhosis from seven sites. Race/ethnicity were similar. Patients with cirrhosis+COVID-19 had higher mortality compared with patients with COVID-19 (30% vs 13%, p=0.03) but not between patients with cirrhosis+COVID-19 and patients with cirrhosis (30% vs 20%, p=0.16). Patients with cirrhosis+COVID-19 versus patients with COVID-19 alone had equivalent respiratory symptoms, chest findings and rates of intensive care unit transfer and ventilation. However, patients with cirrhosis+COVID-19 had worse Charlson Comorbidity Index (CCI 6.5±3.1 vs 3.3±2.5, p<0.001), lower presenting GI symptoms and higher lactate. Patients with cirrhosis alone had higher cirrhosis-related complications, maximum model for end-stage liver disease (MELD) score and lower BiPAP/ventilation requirement compared with patients with cirrhosis+COVID-19, but CCI and ACLF rates were similar. In the entire group, CCI (OR 1.23, 95% CI 1.11 to 1.37, p<0.0001) was the only variable predictive of mortality on multivariable regression. CONCLUSIONS: In this multicentre North American contemporaneously enrolled study, age/gender-matched patients with cirrhosis+COVID-19 had similar mortality compared with patients with cirrhosis alone but higher than patients with COVID-19 alone. CCI was the only independent mortality predictor in the entire matched cohort. url: https://doi.org/10.1136/gutjnl-2020-322118 doi: 10.1136/gutjnl-2020-322118 id: cord-302226-0rhgmtbo author: Bajpai, Vijeta title: Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit date: 2019 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Clinical significance of respiratory viruses (RVs) as an etiology of pneumonia in liver disease patients with cirrhosis is usually underestimated. Therefore, the aim of this study was to evaluate the spectrum of RVs in cirrhotic patients with pneumonia admitted in critical care units (CCUs) and its impact on the clinical outcome of cirrhotic patients. MATERIAL AND METHOD: A prospective study was conducted in a tertiary care CCU, and consecutive cirrhotic patients with pneumonia were included. Bronchoalveolar lavage or throat swab/nasal swab was collected in viral transport medium for analysis of RVs by multiplex real-time polymerase chain reaction. A total of 135 cirrhotic patients were included, viral and bacterial etiology of pneumonia was identified, and analysis was done with the clinical outcome. RESULTS: Overall, RVs were detected in 30 (22.2%) cirrhotic patients and viral–bacterial coinfection in 16 (11.8%) cirrhotic patients. The most common virus detected was rhinovirus in 9 (30%) patients. Mortality in cirrhotic patients with RV infection was significantly higher in comparison to cirrhotic patients with no RV infection (25 [83.3%] and 11 [12.3%], respectively, P < 0.001). CONCLUSION: Respiratory viruses in cirrhotic patients with pneumonia are associated with poor clinical outcome. url: https://www.ncbi.nlm.nih.gov/pubmed/31929704/ doi: 10.4103/jlp.jlp_6_19 id: cord-253256-909chgl0 author: Bajwa, Sukhminder Jit Singh title: Peri-operative and critical care concerns in coronavirus pandemic date: 2020-03-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: World Health Organization (WHO) declared novel coronavirus outbreak a “pandemic” on March 11(th), 2020. India has already reached Stage 2 (local transmission) and the Indian Government, in collaboration with the Indian Council of Medical Research (ICMR), is taking all necessary steps to halt the community transmission(Stage 3). Anaesthesiologists and intensivists around the globe are making untiring efforts akin to soldiers at the final frontier during war. All efforts pertaining to adequate staffing, Personal Protective Equipment (PPE) and strict adherence to hand hygiene measures are being stressed upon to prevent in-hospital transmission. In this article, all outbreak response measures including triaging, preparation of isolation rooms, decontamination and disinfection protocols as well as fundamental principles of critical care and anaesthetic management in Covid-19 cases is being discussed. All the recommendations have been derived from the past experiences of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) outbreak as well as upcoming guidelines from the international health fraternity and Indian Health Services. url: https://doi.org/10.4103/ija.ija_272_20 doi: 10.4103/ija.ija_272_20 id: cord-252617-rqm0p19e author: Baker, Paul A. title: What’s inside the box? Or shall we think outside the box? date: 2020-08-28 words: 827.0 sentences: 53.0 pages: flesch: 48.0 cache: ./cache/cord-252617-rqm0p19e.txt txt: ./txt/cord-252617-rqm0p19e.txt summary: With the deadly and highly transmissible SARS-CoV-2 virus causing the COVID-19 pandemic, there is global concern about the danger of contaminating healthcare workers (HCW), particularly during airway management of infected patients. In this edition of Pediatric Anesthesia, Bryant and Tobias report a laboratory study where there was up to 99.2% decrease of artificial aerosol particles measured outside compared with inside an enclosed clear intubation box using augmented gas flow (suction). 1 At first glance, the concept of a barrier over the patient during airway management seems like a simple and logical option in terms of protecting practitioners from viral infection. Intubation is reported to be a high-risk procedure for aerosol release and transmission of infection to HCWs. Supporting evidence for this comes from a systematic review. The aerosol box for intubation in COVID-19 patients: an in-situ simulation crossover study abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32856770/ doi: 10.1111/pan.13932 id: cord-000831-zwfxnd7r author: Bakhshayeshkaram, Mehrdad title: Imaging Findings in Patients With H1N1 Influenza A Infection date: 2011-12-25 words: 2285.0 sentences: 149.0 pages: flesch: 53.0 cache: ./cache/cord-000831-zwfxnd7r.txt txt: ./txt/cord-000831-zwfxnd7r.txt summary: The initial radiography obtained from the patients was reviewed regarding pattern (consolidation, ground glass, nodules and reticulation), distribution (focal, multifocal, and diffuse) and the lung zones involved. CONCLUSIONS: In patients with the novel swine flu infection, the most common radiographic abnormality observed was consolidation in the lower lung zones. In a study on 66 patients, the most common abnormal pattern was consolidation most commonly observed in the lower and central lung zones and patients admitted to the ICU were more likely to have three or more lung zones involved (4). In their study, patients with bilateral and peripheral involvement or four or more lung zone involvement were more likely to have severe outcome, which is in consistence with our findings in patients admitted to ICU. Another study reviewed the High Resolution Computed Tomography Scan (HRCT) findings of 18 patients with the new swine flu influenza. abstract: BACKGROUND: Swine influenza (H1N1) is a very contagious respiratory infection and World Health Organization (WHO) has raised the alert level to phase 6 (pandemic). The study of clinical and laboratory manifestations as well as radiologic imaging findings helps in its early diagnosis. OBJECTIVES: The aim of this study was to evaluate the imaging findings of patients with documented H1N1 infection referred to our center. PATIENTS AND METHODS: Thirty-one patients (16 men) with documented H1N1 infection were included in our study. The initial radiography obtained from the patients was reviewed regarding pattern (consolidation, ground glass, nodules and reticulation), distribution (focal, multifocal, and diffuse) and the lung zones involved. Computed tomography (CT) scans were also reviewed for the same abnormalities. The patient files were studied for their possible underlying diseases. RESULTS: The mean age was 37.97 ± 13.9 years. Seventeen (54.8%) patients had co-existing condition (eight respiratory, five cardiovascular, two immunodeficiency, two cancer, four others). Twelve (38.7%) patients required intensive care unit (ICU) admission. Five (16.1%) patients died. (25.8%) had normal initial radiographs. The most common abnormality was consolidation (12/31; 38.7%) in the peripheral region (11/31; 35.5%) followed by peribronchovascular areas (10/31; 32.3%) which was most commonly observed in the lower zone. The patients admitted to the ICU were more likely to have two or more lung zones involved (P = 0.005). CONCLUSIONS: In patients with the novel swine flu infection, the most common radiographic abnormality observed was consolidation in the lower lung zones. Patients admitted to ICU were more likely to have two or more lung zones involved. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522360/ doi: 10.5812/iranjradiol.4554 id: cord-295414-v10454ns author: Baktash, Vadir title: Vitamin D status and outcomes for hospitalised older patients with COVID-19 date: 2020-08-26 words: 3757.0 sentences: 234.0 pages: flesch: 46.0 cache: ./cache/cord-295414-v10454ns.txt txt: ./txt/cord-295414-v10454ns.txt summary: 1 Furthermore, research by Alipio and colleagues 2 , in a retrospective study, provides evidence of an association between vitamin D deficiency and adverse outcome in patients with COVID-19. Among patients with vitamin D deficiency in the COVID-19-positive group, there was a higher average peak in D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and a higher incidence of NIV support and HDU admission (30.77% vs 9.68%) (p=0.042). The main findings of our study suggest that older patients with lower serum concentrations of 25(OH)D, when compared with aged-matched vitamin D-replete patients, may demonstrate worse outcomes from COVID-19. In non-communicable diseases, both viral and bacterial, vitamin D deficiency has been associated with increased morbidity and mortality as well as a higher incidence of acute respiratory distress syndrome in critically unwell patients. • Older patients with COVID-19 infection and vitamin D deficiency (≤30 nmol/L) have higher peak D-dimer level and higher incidence of NIV support and HDU admission. abstract: PURPOSE: Older adults are more likely to be vitamin D deficient. The aim of the study was to determine whether these patients have worse outcomes with COVID-19. METHODS: We conducted a prospective cohort study between 1 March and 30 April 2020 to assess the importance of vitamin D deficiency in older patients with COVID-19. The cohort consisted of patients aged ≥65 years presenting with symptoms consistent with COVID-19 (n=105). All patients were tested for serum 25-hydroxyvitamin D (25(OH)D) levels during acute illness. Diagnosis of COVID-19 was confirmed via viral reverse transcriptase PCR swab or supporting radiological evidence. COVID-19-positive arm (n=70) was sub-divided into vitamin D-deficient (≤30 nmol/L) (n=39) and -replete groups (n=35). Subgroups were assessed for disease severity using biochemical, radiological and clinical markers. Primary outcome was in-hospital mortality. Secondary outcomes were laboratory features of cytokine storm, thoracic imaging changes and requirement of non-invasive ventilation (NIV). RESULTS: COVID-19-positive arm demonstrated lower median serum 25(OH)D level of 27 nmol/L (IQR=20–47 nmol/L) compared with COVID-19-negative arm, with median level of 52 nmol/L (IQR=31.5–71.5 nmol/L) (p value=0.0008). Among patients with vitamin D deficiency, there was higher peak D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and higher incidence of NIV support and high dependency unit admission (30.77% vs 9.68%) (p=0.042). No increased mortality was observed between groups. CONCLUSION: Older adults with vitamin D deficiency and COVID-19 may demonstrate worse morbidity outcomes. Vitamin D status may be a useful prognosticator. url: https://doi.org/10.1136/postgradmedj-2020-138712 doi: 10.1136/postgradmedj-2020-138712 id: cord-274199-3stjueja author: Baldi, Enrico title: COVID-19 kills at home: the close relationship between the epidemic and the increase of out-of-hospital cardiac arrests date: 2020-06-20 words: 4307.0 sentences: 193.0 pages: flesch: 48.0 cache: ./cache/cord-274199-3stjueja.txt txt: ./txt/cord-274199-3stjueja.txt summary: Our aim was to assess whether the difference in the number of OHCAs between 2020 and 2019 was statistically correlated with the COVID-19 epidemic trend and to look for clinical pre-hospital elements supporting this evidence. All the Emergency Medical System (EMS) electronic records have been reanalysed and the number of patients with suspected COVID-19 (fever for at least 3 days before OHCA associated with cough and/or dyspnoea) or with a diagnostic pharyngeal swab (performed before OHCA or after death) have been computed. We highlighted an increase in medical aetiology over other types of aetiologies, and this further reinforces the hypothesis that the increase in the incidence of OHCAs is probably related to the direct (i.e. respiratory failure at home, SCD due to SARS-CoV-2 myocardial involvement or treatment) or indirect (i.e. lack of EMS activation in the case of time-dependent pathologies) effect of the COVID-19 epidemic. abstract: AIMS: An increase in out-of-hospital cardiac arrest (OHCA) incidence has been reported in the very early phase of the COVID-19 epidemic, but a clear demonstration of a correlation between the increased incidence of OHCA and COVID-19 is missing so far. We aimed to verify whether there is an association between the OHCA difference compared with 2019 and the COVID-19 epidemic curve. METHODS AND RESULTS: We included all the consecutive OHCAs which occurred in the Provinces of Lodi, Cremona, Pavia, and Mantova in the 2 months following the first documented case of COVID-19 in the Lombardia Region and compared them with those which occurred in the same time frame in 2019. The cumulative incidence of COVID-19 from 21 February to 20 April 2020 in the study territory was 956 COVID-19/100 000 inhabitants and the cumulative incidence of OHCA was 21 cases/100 000 inhabitants, with a 52% increase as compared with 2019 (490 OHCAs in 2020 vs. 321 in 2019). A strong and statistically significant correlation was found between the difference in cumulative incidence of OHCA between 2020 and 2019 per 100 000 inhabitants and the COVID-19 cumulative incidence per 100 000 inhabitants both for the overall territory (ρ 0.87, P < 0.001) and for each province separately (Lodi: ρ 0.98, P < 0.001; Cremona: ρ 0.98, P < 0.001; Pavia: ρ 0.87, P < 0.001; Mantova: ρ 0.81, P < 0.001). CONCLUSION: The increase in OHCAs in 2020 is significantly correlated to the COVID-19 pandemic and is coupled with a reduction in short-term outcome. Government and local health authorities should seriously consider our results when planning healthcare strategies to face the epidemic, especially considering the expected recurrent outbreaks. url: https://doi.org/10.1093/eurheartj/ehaa508 doi: 10.1093/eurheartj/ehaa508 id: cord-266475-t04pukea author: Balestri, R. title: Late onset of acral necrosis after SARS‐CoV‐2 infection resolution date: 2020-05-26 words: 862.0 sentences: 46.0 pages: flesch: 45.0 cache: ./cache/cord-266475-t04pukea.txt txt: ./txt/cord-266475-t04pukea.txt summary: [1] [2] [3] [4] SARS-CoV-2 has been hypothesized as the aetiologic agent of CLL, on the basis of the temporal correlation between the "burst" of skin manifestations and the viral pandemic, even though we have scarce evidence of swab-confirmed infections. Authors have therefore suggested some pathogenetic mechanisms such as a delayed immunemediated reaction to the virus in genetically-predisposed patients 1 or an early IFN-I response in young patients, muting early viral replication but also inducing microangiopathic changes. [4] [5] [6] We would like to report a case of SARS-CoV-2-related acro-ischemia, peculiar for several reasons: i) the patient presented real acral ischemia that progressed toward necrosis; ii) she was otherwise completely asymptomatic; iii) she was on regular medication with warfarin for atrial fibrillation. Characterization of acute acro-ischemic lesions in non-hospitalized patients: a case series of 132 patients during the COVID-19 outbreak abstract: SARS‐CoV‐2 has been hypothesized as the aetiologic agent of CLL, on the basis of the temporal correlation between the “burst” of skin manifestations and the viral pandemic, even though we have scarce evidence of swab‐confirmed infections. Authors have therefore suggested some pathogenetic mechanisms such as a delayed immune‐mediated reaction to the virus in genetically‐predisposed patients(1) or an early IFN‐I response in young patients, muting early viral replication but also inducing microangiopathic changes. url: https://www.ncbi.nlm.nih.gov/pubmed/32455499/ doi: 10.1111/jdv.16668 id: cord-353956-gjv5cg3k author: Bali, Rishi Kumar title: Maxillofacial surgery and COVID-19, The Pandemic !! date: 2020-04-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s12663-020-01361-8 doi: 10.1007/s12663-020-01361-8 id: cord-355528-y4a1g6km author: Balla, Mamtha title: COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective date: 2020-03-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19) caused infection in 168,000 cases worldwide in about 148 countries and killed more than 6,610 people around the world as of March 16, 2020, as per the World Health Organization (WHO). Compared to severe acute respiratory syndrome and Middle East respiratory syndrome, there is the rapid transmission, long incubation period, and disease containment is becoming extremely difficult. The main aim of this systematic review is to provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. We also discussed various preventive measures to combat COVID-19 effectively. A systematic and protocol-driven approach is needed to contain this disease, which was declared as a global pandemic on March 11, 2020, by the WHO. url: https://doi.org/10.14740/jocmr4142 doi: 10.14740/jocmr4142 id: cord-006508-rje9bnph author: Ballas, Samir K. title: Sickle Cell Anaemia: Progress in Pathogenesis and Treatment date: 2012-10-10 words: 14697.0 sentences: 848.0 pages: flesch: 49.0 cache: ./cache/cord-006508-rje9bnph.txt txt: ./txt/cord-006508-rje9bnph.txt summary: Lack of understanding of the nature and pathophysiology of the pain associated with sickle cell anaemia hampered rational approaches of therapy and had an adverse effect on the quality of life of an already compromised health status of affected patients. Beneficial effects of hydroxyurea in patients with sickle cell anaemia Decreases the frequency of acute painful episodes Decreases the incidence of acute chest syndrome Decreases the blood transfusion requirement Decreases morbidity and mortality error where a change of one letter of a keyword of a manuscript (''punctuation mutation'') corrupts the meaning of the intended message. [48] These include: (i) the risk associated with the inhibiting effect of MAb 73E on platelet function with an unpredictable net clinical effect (i.e. thrombosis versus bleeding); and (ii) to be effective, these antibodies have to be administered before the RBC adhere to the vessel wall (i.e., pre-treatment before the onset of a vaso-occlusive event) a scenario that is unpredictable in patients with sickle cell anaemia. abstract: The phenotypic expression of sickle cell anaemia varies greatly among patients and longitudinally in the same patient. It influences all aspects of the life of affected individuals including social interactions, intimate relationships, family relations, peer interactions, education, employment, spirituality and religiosity. The clinical manifestations of sickle cell anaemia are protean and fall into three major categories: (i) anaemia and its sequelae; (ii) pain and related issues; and (iii) organ failure including infection. Recent studies on the pathogenesis of sickle cell anaemia have centred on the sequence of events that occur between polymerisation of deoxy haemoglobin (Hb) S and vaso-occlusion. Cellular dehydration, inflammatory response and reperfusion injury seem to be important pathophysiological mechanisms. Management of sickle cell anaemia continues to be primarily palliative in nature, including supportive, symptomatic and preventative approaches to therapy. Empowerment and education are the major aspects of supportive care. Symptomatic management includes pain management, blood transfusion and treatment of organ failure. Pain managment should follow certain priniciples that include assessment, individualisation of therapy and proper utilisation of opioid and non-opioid analgesics in order to acheive adequate pain relief. Blood selected for transfusion should be leuko-reduced and phenotypically matched for the C, E and Kell antigens. Exchange transfusion is indicated in patients who are transfused chronically in order to prevent or delay the onset of iron-overload. Acute chest syndrome is the most common form of organ failure and its management should be agressive, including adequate ventilation, multiple antibacterials and simple or exchange blood transfusion depending on its severity. Preventitive therapy includes prophylactic penicillin in infants and children, blood transfusion (preferably exchange transfusion) in patients with stroke, and hydroxyurea in patients with frequent acute painful episodes. Bone marrow and cord blood transplantation have been successful modalities of curative therapy in selected children with sickle cell anaemia. Newer approaches to preventative therapy include cellular rehydration with agents that inhibit the Gardos channel or the KCl co-transport channel. Curative gene therapy continues to be investigational at the level of the test tube and transgenic mouse models. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101942/ doi: 10.2165/00003495-200262080-00003 id: cord-018412-kv3vxmcw author: Bambi, Stefano title: Evolution of Intensive Care Unit Nursing date: 2017-10-06 words: 8546.0 sentences: 428.0 pages: flesch: 43.0 cache: ./cache/cord-018412-kv3vxmcw.txt txt: ./txt/cord-018412-kv3vxmcw.txt summary: In future, increases in the number of ICU beds relative to bed numbers in other hospital wards will probably be contemplated, even in a scenario of decreasing costs; clinical protocols will be computerized and/or nurse-driven; more multicenter and international trials will be performed; and organizational strategies will concentrate ICU personnel in a few large units, to promote the flexible management of these healthcare workers. Moreover, extracorporeal organ support technologies will be improved; technology informatics will cover all the bureaucratic aspects of healthcare work, aiding the staff in workload assessment; and critical care multidisciplinary rounds and follow-up services for post-ICU patients will be implemented. • Development of methods for fast recognition of acute patients at high risk of rapid deterioration • Minimally invasive organ support technologies • New approaches to enhance patient comfort while reducing changes of consciousness • Effective process and outcome measurements for critical illness research and palliative and EOL care. abstract: The specialties of critical care medicine and critical care nursing arose to provide special treatment and care to the most severely ill hospital patients. However, critical care medicine does not seem to have made any major therapeutic progress in the past 30 years. The reduction of mortality in intensive care units (ICUs) is due essentially to improvements in both supportive care and the relevant technologies. In future, increases in the number of ICU beds relative to bed numbers in other hospital wards will probably be contemplated, even in a scenario of decreasing costs; clinical protocols will be computerized and/or nurse-driven; more multicenter and international trials will be performed; and organizational strategies will concentrate ICU personnel in a few large units, to promote the flexible management of these healthcare workers. Moreover, extracorporeal organ support technologies will be improved; technology informatics will cover all the bureaucratic aspects of healthcare work, aiding the staff in workload assessment; and critical care multidisciplinary rounds and follow-up services for post-ICU patients will be implemented. Lastly, a better continuum of care between the pre-hospital phase, the emergency care phase, the ICU phase, and the post-ICU phase should be achieved. Also, policies should be drafted to manage sudden large demands for critical care beds in mega-emergencies. The main lines of discussion in critical care nursing research should include nursing research priorities in critical care patients, holistic approaches to the patient, the humanization of care, special populations of ICU patients, and challenges related to critical care nursing during emerging outbreaks of infectious diseases. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123277/ doi: 10.1007/978-3-319-50559-6_19 id: cord-303145-rc5luali author: Banach, Maciej title: Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic date: 2020-05-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32389859/ doi: 10.1016/j.phrs.2020.104891 id: cord-343970-anocx4y1 author: Bansal, Rashika title: Metabolic Syndrome and COVID 19: Endocrine-Immune-Vascular Interactions Shapes Clinical Course date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Individuals with metabolic syndrome are at increased risk for poor disease outcomes and mortality from COVID-19. The pathophysiologic mechanisms for these observations have not been fully elucidated. A critical interaction between SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2) facilitates viral entry into the host cell. ACE2 is expressed in pancreatic islets, vascular endothelium, and adipose tissue, and the SARS-CoV-2 -ACE2 interaction in these tissues, along with other factors, govern the spectrum and the severity of clinical manifestations among COVID-19 patients with metabolic syndrome. Moreover, the pro-inflammatory milieu observed in patients with metabolic syndrome may contribute towards COVID-19-mediated host immune dysregulation, including sub-optimal immune responses, hyper-inflammation, microvascular dysfunction, and thrombosis. This review describes the spectrum of clinical features, the likely pathophysiologic mechanisms and potential implications for the management of metabolic syndrome in COVID-19 patients. url: https://doi.org/10.1210/endocr/bqaa112 doi: 10.1210/endocr/bqaa112 id: cord-294270-do6i6ymq author: Banu, Buyukaydin title: Pneumonia date: 2019-11-29 words: 7319.0 sentences: 426.0 pages: flesch: 37.0 cache: ./cache/cord-294270-do6i6ymq.txt txt: ./txt/cord-294270-do6i6ymq.txt summary: A population-based cohort study with 46,237 elderly patients found that immunosuppression, COPD, smoking, congestive heart failure, diabetes, malignancy, and previous hospitalizations for pneumonia are independent risk factors for developing the disease in this age group (Barlow et al., 2007) . Presence of comorbidities such as chronic heart, lung, liver or renal disease; diabetes mellitus; alcoholism; malignancies; asplenia; immunosuppressing conditions or use of immunosuppressing drugs; or use of antimicrobials within the previous 3 months A respiratory fluoroquinolone (moxifloxacin, gemifloxacin, or levofloxacin [750 mg]) (strong recommendation) (1 point) ATS, American Thoracic Society; CAP, community-acquired pneumonia; ICU, ıntensive care unit; IDST, Infectious Diseases Society of America; PIRO, predisposition, infection, response and organ dysfunction score; PS CURXO80, pH, systolic blood pressure, confusion, urea nitrogen, respiratory rate, x-ray finding, oxygen arterial pressure and age of 80 years or more; SMART-COP, systolic blood pressure, multilobar chest radiography, albumin level, respiratory rate, tachycardia, confusion, oxygenation and pH; BUN, blood urea nitrogen; WBC, white blood cell. abstract: Pneumonia remains the main cause of morbidity and mortality from infectious diseases in the world. The important reason for the increased global mortality is the impact of pneumonia on chronic diseases especially in the elderly population and the virulence factors of the causative microorganisms. Because elderly individuals present with comorbidities, particular attention should be paid for multidrug-resistant pathogens. Streptococcus pneumoniae remains the most frequently encountered pathogen. Enteric gram-negative rods, as well as anaerobes, should be considered in patients with aspiration pneumonia. Interventions for modifiable risk factors will reduce the risk of this infection. The adequacy of the initial antimicrobial therapy and determination of patients’ follow-up place is a key factor for prognosis. Also, vaccination is one of the most important preventive measures. In this section it was focused on several aspects, including the atypical presentation of pneumonia in the elderly, the methods to evaluate the severity of illness, the appropriate take care place and the management with prevention strategies. url: https://api.elsevier.com/content/article/pii/B9780128012383621748 doi: 10.1016/b978-0-12-801238-3.62174-8 id: cord-300866-cso6l6ze author: Bao, Yi title: Clinical Features of COVID-19 in a Young Man with Massive Cerebral Hemorrhage—Case Report date: 2020-05-23 words: 4252.0 sentences: 217.0 pages: flesch: 50.0 cache: ./cache/cord-300866-cso6l6ze.txt txt: ./txt/cord-300866-cso6l6ze.txt summary: Both SARS-CoV-2 nucleic acid tests were negative (24 h interval), Fig. 2 The treatment of COVID-19 patients with intracerebral hemorrhage suggesting that antiviral treatment was effective. On February 29, the patient did not have high fever again, the results of the cerebrospinal fluid review showed that it was light red, no clot, protein decreased to 0.8 g/L, sugar increased to 4.45 mmol/L, and white blood cells decreased to 37 × 10 6 G/L, of which monocytes accounted for 74%. The patient''s cerebrospinal fluid showed improvement, and since the two re-examinations of SARS-CoV-2 nucleic acid test was negative, and the antiviral treatment with Abidol, Ribavirin, and Oseltamivir had reached the course of treatment, so it was discontinued. However, in combination with the patient''s high fever, lymphocytopenia, increased neutrophils, and poor antibacterial treatment effect, the clinical manifestations conform to the COVID-19 characteristics, and nucleic acid detection is required. abstract: COVID-19 is currently a pandemic in the world, can invade multiple systems, and has a high morbidity and mortality. So far, no cases of acute cerebrovascular disease have been reported. This article reports the clinical features of a COVID-19 patient whose first symptom was cerebral hemorrhage. More importantly, after the craniotomy, the patient had high fever and it was difficult to retreat. After cerebrospinal fluid testing, it was determined that an intracranial infection had occurred. After anti-infection and plasma infusion of the recovered person, the patient’s symptoms gradually improved. This case suggests that COVID-19 may infringe on cerebral blood vessels and cause cerebral hemorrhage. Transfusion of plasma from rehabilitation patients is effective for critically ill patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32838132/ doi: 10.1007/s42399-020-00315-y id: cord-276927-rxudwp2v author: Barbas, Carmen Sílvia Valente title: Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome date: 2012-08-23 words: 7991.0 sentences: 374.0 pages: flesch: 35.0 cache: ./cache/cord-276927-rxudwp2v.txt txt: ./txt/cord-276927-rxudwp2v.txt summary: Rapid administration of antibiotics and resuscitative measures in case of sepsis and septic shock associated with protective ventilatory strategies and early short-term paralysis associated with differential ventilatory techniques (recruitment maneuvers with adequate positive end-expiratory pressure titration, prone position, and new extracorporeal membrane oxygenation techniques) in severe ARDS can help improve its prognosis. Incorporation of modified risk factors such as acute increase of respiratory rate, presence of tachypnea, detection of pulse oximeter desaturation, increased necessity of oxygen supplementation, presence of low pH, acidosis, or hypoxemia in an arterial blood gas sample in clinical practice can improve the clinicians'' ability to perform early diagnosis and prompt therapeutic intervention in ARDS [17] . abstract: This paper, based on relevant literature articles and the authors' clinical experience, presents a goal-oriented respiratory management for critically ill patients with acute respiratory distress syndrome (ARDS) that can help improve clinicians' ability to care for these patients. Early recognition of ARDS modified risk factors and avoidance of aggravating factors during hospital stay such as nonprotective mechanical ventilation, multiple blood products transfusions, positive fluid balance, ventilator-associated pneumonia, and gastric aspiration can help decrease its incidence. An early extensive clinical, laboratory, and imaging evaluation of “at risk patients” allows a correct diagnosis of ARDS, assessment of comorbidities, and calculation of prognostic indices, so that a careful treatment can be planned. Rapid administration of antibiotics and resuscitative measures in case of sepsis and septic shock associated with protective ventilatory strategies and early short-term paralysis associated with differential ventilatory techniques (recruitment maneuvers with adequate positive end-expiratory pressure titration, prone position, and new extracorporeal membrane oxygenation techniques) in severe ARDS can help improve its prognosis. Revaluation of ARDS patients on the third day of evolution (Sequential Organ Failure Assessment (SOFA), biomarkers and response to infection therapy) allows changes in the initial treatment plans and can help decrease ARDS mortality. url: https://doi.org/10.1155/2012/952168 doi: 10.1155/2012/952168 id: cord-303017-4zx94rm6 author: Barbieri, Antonio title: Can Beta-2-Adrenergic Pathway Be a New Target to Combat SARS-CoV-2 Hyperinflammatory Syndrome?—Lessons Learned From Cancer date: 2020-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SARS-CoV-2 infection is a new threat to global public health in the 21(st) century (2020), which has now rapidly spread around the globe causing severe pneumonia often linked to Acute Respiratory Distress Syndrome (ARDS) and hyperinflammatory syndrome. SARS-CoV-2 is highly contagious through saliva droplets. The structural analysis suggests that the virus enters human cells through the ligation of the spike protein to angiotensin-converting enzyme 2 (ACE(2)). The progression of Covid-19 has been divided into three main stages: stage I—viral response, stage II—pulmonary phase, and stage III—hyperinflammation phase. Once the patients enter stage III, it will likely need ventilation and it becomes difficult to manage. Thus, it will be of paramount importance to find therapies to prevent or slow down the progression of the disease toward stage III. The key event leading to hyperinflammation seems to be the activation of Th-17 immunity response and Cytokine storm. B(2)-adrenergic receptors (B(2)ARs) are expressed on airways and on all the immune cells such as macrophages, dendritic cells, B and T lymphocytes. Blocking (B(2)AR) has been proven, also in clinical settings, to reduce Th-17 response and negatively modulate inflammatory cytokines including IL-6 while increasing IFNγ. Non-selective beta-blockers are currently used to treat several diseases and have been proven to reduce stress-induced inflammation and reduce anxiety. For these reasons, we speculate that targeting B(2)AR in the early phase of Covid-19 might be beneficial to prevent hyperinflammation. url: https://doi.org/10.3389/fimmu.2020.588724 doi: 10.3389/fimmu.2020.588724 id: cord-349144-cvmebr3f author: Barca, Ida title: Telemedicine in Oral and Maxillo-Facial Surgery: An Effective Alternative in Post COVID-19 Pandemic date: 2020-10-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The aim of this work was to demonstrate the advantages of using telemedicine (TM) in the management of the outpatients with maxillofacial surgical pathologies during the COVID-19 pandemic. The study was conducted at the MaxilloFacial Surgery Unit of “Magna Graecia” University of Catanzaro, on two different groups of patients: a group of follow-up patients (A(1): patients in oncological follow-up after surgical treatment performed before the COVID-19 pandemic; A(2): suffering from chronic lesions such as precancerous lesions), and a group B of patients with first urgent visits (B(1): patients with suspected oncological pathology; B(2): patients with suspected urgent disease such as medication-related osteonecrosis of the jaws (MRONJ), odontogenic abscesses, temporomandibular joint (TMJ) dislocation, etc.). Participation in the study required possession of a smartphone with Internet access, e-mail and the use of a messaging service (WhatsApp or Telegram) to send photos and messages; completion by the patient of a COVID-19 screening questionnaire; submission of a satisfaction questionnaire by the doctors and patients. A total of 90 patients were included in this study. A high percentage of satisfaction emerged from the analysis of the satisfaction questionnaires of both patients and doctors.TM thus represents an excellent opportunity to improve accessibility to oncological and non-management activities, reducing the risk of Covid-19 dissemination and should be promoted and implemented in the post-pandemic era. url: https://doi.org/10.3390/ijerph17207365 doi: 10.3390/ijerph17207365 id: cord-336000-v88bq4bx author: Barco, Stefano title: Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date: 2020-09-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. TRIAL DESIGN: The OVID study is conducted as a multicentre open-label superiority randomised controlled trial. PARTICIPANTS: Inclusion Criteria 1. Signed patient informed consent after being fully informed about the study’s background. 2. Patients aged 50 years or older with a positive test for SARS-CoV2 in the past 5 days and eligible for ambulatory treatment. 3. Presence of respiratory symptoms (i.e. cough, sore throat, or shortness of breath) or body temperature >37.5° C. 4. Ability of the patient to travel to the study centre by private transportation, performed either by an accompanying person from the same household or by the patient themselves 5. Ability to comply with standard hygiene requirements at the time of in-hospital visit, including a face mask and hand disinfectant. 6. Ability to walk from car to study centre or reach it by wheelchair transport with the help of an accompanying person from the same household also complying with standard hygiene requirements. 7. Ability to self-administer prefilled enoxaparin injections after instructions received at the study centre or availability of a person living with the patient to administer enoxaparin. Exclusion Criteria 1. Any acute or chronic condition posing an indication for anticoagulant treatment, e.g. atrial fibrillation, prior venous thromboembolism (VTE), acute confirmed symptomatic VTE, acute coronary syndrome. 2. Anticoagulant thromboprophylaxis deemed necessary in view of the patient's history, comorbidity or predisposing strong risk factors for thrombosis: a. Any of the following events occurring in the prior 30 days: fracture of lower limb, hospitalization for heart failure, hip/knee replacement, major trauma, spinal cord injury, stroke, b. previous VTE, c. histologically confirmed malignancy, which was diagnosed or treated (surgery, chemotherapy, radiotherapy) in the past 6 months, or recurrent, or metastatic, or inoperable. 3. Any clinically relevant bleeding (defined as bleeding requiring hospitalization, transfusion, surgical intervention, invasive procedures, occurring in a critical anatomical site, or causing disability) within 30 days prior to randomization or sign of acute bleeding. 4. Intracerebral bleeding at any time in the past or signs/symptoms consistent with acute intracranial haemorrhage. 5. Haemoglobin <8 g/dL and platelet count <50 x 10(9) cells/L confirmed by recent laboratory test (<90 days). 6. Subjects with any known coagulopathy or bleeding diathesis, including known significant liver disease associated with coagulopathy. 7. Severe renal insufficiency (baseline creatinine clearance <30 mL/min calculated using the Cockcroft-Gault formula) confirmed by recent laboratory test (<90 days). 8. Contraindications to enoxaparin therapy, including prior heparin-induced thrombocytopenia and known hypersensitivity. 9. Current use of dual antiplatelet therapy. 10. Participation in other interventional studies over the past 30 days. 11. Non-compliance or inability to adhere to treatment or lack of a family environment or support system for home treatment. 12. Cognitive impairment and/or inability to understand information provided in the study information. Patient enrolment will take place at seven Swiss centres, including five university hospitals and two large cantonal hospitals. INTERVENTION AND COMPARATOR: Patients randomized to the intervention group will receive subcutaneous enoxaparin at the recommended dose of 4,000 IU anti-Xa activity (40 mg/0.4 ml) once daily for 14 days. Patients randomized to the comparator group will receive no anticoagulation. MAIN OUTCOMES: Primary outcome: a composite of any hospitalization or all-cause death occurring within 30 days of randomization. Secondary outcomes: (i) a composite of cardiovascular events, including deep vein thrombosis (including catheter-associated), pulmonary embolism, myocardial infarction/myocarditis, arterial ischemia including mesenteric and extremities, acute splanchnic vein thrombosis, or ischemic stroke within 14 days, 30 days, and 90 days of randomization; (ii) each component of the primary efficacy outcome, within 14 days, 30 days, and 90 days of randomization; (iii) net clinical benefit (accounting for the primary efficacy outcome, composite cardiovascular events, and major bleeding), within 14 days, 30 days, and 90 days of enrolment; (iv) primary efficacy outcome, within 14 days, and 90 days of enrolment; (v) disseminated intravascular coagulation (ISTH criteria, in-hospital diagnosis) within 14 days, 30 days, and 90 days of enrolment. RANDOMISATION: Patients will undergo block stratified randomization (by age: 50-70 vs. >70 years; and by study centre) with a randomization ratio of 1:1 with block sizes varying between 4 and 8. Randomization will be performed after the signature of the informed consent for participation and the verification of the eligibility criteria using the electronic data capture software (REDCAP, Vanderbilt University, v9.1.24). BLINDING (MASKING): In this open-label study, no blinding procedures will be used. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): The sample size calculation is based on the parameters α = 0.05 (2-sided), power: 1−β = 0.8, event rate in experimental group, pexp = 0.09 and event rate in control group, pcon = 0.15. The resulting total sample size is 920. To account for potential dropouts, the total sample size was fixed to 1000 with 500 patients in the intervention group and 500 in the control group. TRIAL STATUS: Protocol version 1.0, 14 April 2020. Protocol version 3.0, 18 May 2020 Recruiting start date: June 2020. Last Patient Last Visit: March 2021. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04400799 First Posted: May 26, 2020 Last Update Posted: July 16, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://doi.org/10.1186/s13063-020-04678-4 doi: 10.1186/s13063-020-04678-4 id: cord-310539-8zk3hkgj author: Barengolts, Elena title: PERSEVERE OR PERIL: DIABETES CARE IN TIMES OF COVID-19 date: 2020-08-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.4158/ep-2020-0227 doi: 10.4158/ep-2020-0227 id: cord-302576-fv2ib5vc author: Barisione, Emanuela title: Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Data on the pathology of COVID-19 are scarce; available studies show diffuse alveolar damage; however, there is scarce information on the chronologic evolution of COVID-19 lung lesions. The primary aim of the study is to describe the chronology of lung pathologic changes in COVID-19 by using a post-mortem transbronchial lung cryobiopsy approach. Our secondary aim is to correlate the histologic findings with computed tomography patterns. SARS-CoV-2-positive patients, who died while intubated and mechanically ventilated, were enrolled. The procedure was performed 30 min after death, and all lung lobes sampled. Histopathologic analysis was performed on thirty-nine adequate samples from eight patients: two patients (illness duration < 14 days) showed early/exudative phase diffuse alveolar damage, while the remaining 6 patients (median illness duration—32 days) showed progressive histologic patterns (3 with mid/proliferative phase; 3 with late/fibrotic phase diffuse alveolar damage, one of which with honeycombing). Immunohistochemistry for SARS-CoV-2 nucleocapsid protein was positive predominantly in early-phase lesions. Histologic patterns and tomography categories were correlated: early/exudative phase was associated with ground-glass opacity, mid/proliferative lesions with crazy paving, while late/fibrous phase correlated with the consolidation pattern, more frequently seen in the lower/middle lobes. This study uses an innovative cryobiopsy approach for the post-mortem sampling of lung tissues from COVID-19 patients demonstrating the progression of fibrosis in time and correlation with computed tomography features. These findings may prove to be useful in the correct staging of disease, and this could have implications for treatment and patient follow-up. url: https://doi.org/10.1007/s00428-020-02934-1 doi: 10.1007/s00428-020-02934-1 id: cord-343452-4m0ub9iv author: Barkama, Ravit title: Placenta-Derived Cell Therapy to Treat Patients With Respiratory Failure Due to Coronavirus Disease 2019 date: 2020-09-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To determine whether placental cell therapy PLacental eXpanded (PLX)-PAD (Pluristem Therapeutics, Haifa, Israel) may be beneficial to treating critically ill patients suffering from acute respiratory distress syndrome due to coronavirus disease 2019. DESIGN: Retrospective case report of critically ill coronavirus disease 2019 patients treated with PLacental eXpanded (PLX)-PAD from March 26, 2020, to April 4, 2020, with follow-up through May 2, 2020. SETTING: Four hospitals in Israel (Rambam Health Care Campus, Bnai Zion Medical Center, and Samson Assuta Ashdod University Hospital), and Holy Name Medical Center in New Jersey. PATIENTS: Eight critically ill patients on invasive mechanical ventilation, suffering from acute respiratory distress syndrome due to coronavirus disease 2019. INTERVENTIONS: Intramuscular injection of PLacental eXpanded (PLX)-PAD (300 × 10(6) cells) given as one to two treatments. MEASUREMENTS AND MAIN RESULTS: Mortality, time to discharge, and changes in blood and respiratory variables were monitored during hospitalization to day 17 posttreatment. Of the eight patients treated (median age 55 yr, seven males and one female), five were discharged, two remained hospitalized, and one died. By day 3 postinjection, mean C-reactive protein fell 45% (240.3–131.3 mg/L; p = 0.0019) and fell to 77% by day 5 (56.0 mg/L; p < 0.0001). Pao(2)/Fio(2) improved in 5:8 patients after 24-hour posttreatment, with similar effects 48-hour posttreatment. A decrease in positive end-expiratory pressure and increase in pH were statistically significant between days 0 and 14 (p = 0.0032 and p = 0.00072, respectively). A decrease in hemoglobin was statistically significant for days 0–5 and 0–14 (p = 0.015 and p = 0.0028, respectively), whereas for creatinine, it was statistically significant between days 0 and 14 (p = 0.032). CONCLUSIONS: Improvement in several variables such as C-reactive protein, positive end-expiratory pressure, and Pao(2)/Fio(2) was observed following PLacental eXpanded (PLX)-PAD treatment, suggesting possible therapeutic effect. However, interpretation of the data is limited due to the small sample size, use of concomitant investigational therapies, and the uncontrolled study design. The efficacy of PLacental eXpanded (PLX)-PAD in coronavirus disease 2019 should be further evaluated in a controlled clinical trial. url: https://www.ncbi.nlm.nih.gov/pubmed/32984833/ doi: 10.1097/cce.0000000000000207 id: cord-326752-45ckkv01 author: Barnett, Brian title: Keeping the wolf at bay: Infection prevention and control measures for inpatient psychiatric facilities in the time of COVID-19 date: 2020-07-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32682153/ doi: 10.1016/j.genhosppsych.2020.07.004 id: cord-314218-6znw9zcz author: Baron, D. M. title: Patient blood management during the COVID–19 pandemic: a narrative review date: 2020-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As COVID–19 disease escalates globally, optimising patient outcome during this catastrophic healthcare crisis is the number one priority. The principles of patient blood management are fundamental strategies to improve patient outcomes and should be given high priority in this crisis situation. The aim of this expert review is to provide clinicians and healthcare authorities with information regarding how to apply established principles of patient blood management during the COVID–19 pandemic. In particular, this review considers the impact of the COVID–19 pandemic on blood supply and specifies important aspects of donor management. We discuss how preventative and control measures implemented during the COVID–19 crisis could affect the prevalence of anaemia, and highlight issues regarding the diagnosis and treatment of anaemia in patients requiring elective or emergency surgery. In addition, we review aspects related to patient blood management of critically ill patients with known or suspected COVID–19, and discuss important alterations of the coagulation system in patients hospitalised due to COVID–19. Finally, we address special considerations pertaining to supply‐demand and cost‐benefit issues of patient blood management during the COVID–19 pandemic. url: https://doi.org/10.1111/anae.15095 doi: 10.1111/anae.15095 id: cord-344120-7t5ce2hb author: Baroutjian, Amanda title: SARS-CoV-2 pharmacologic therapies and their safety/effectiveness according to level of evidence date: 2020-09-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: There is a pressing need for COVID-19 transmission control and effective treatments. We aim to evaluate the safety and effectiveness of SARS-CoV-2 pharmacologic therapies as of August 2, 2020 according to study level of evidence. METHODS: PubMed, ScienceDirect, Cochrane Library, JAMA Network and PNAS were searched. The following keywords were used: ((COVID-19) OR (SARS-CoV-2)) AND ((((((therapeutics) OR (treatment)) OR (vaccine)) OR (hydroxychloroquine)) OR (antiviral)) OR (prognosis)). Results included peer-reviewed studies published in English. RESULTS: 15 peer-reviewed articles met study inclusion criteria, of which 14 were RCTs and one was a systematic review with meta-analysis. The following pharmacologic therapies were evaluated: chloroquine (CQ), hydroxychloroquine (HCQ), antivirals therapies, plasma therapy, anti-inflammatories, and a vaccine. CONCLUSION: According to level 1 evidence reviewed here, the most effective SARS-Co-V-2 pharmacologic treatments include remdesivir for mild to severe disease, and a triple regimen therapy consisting of lopinavir-ritonavir, ribavirin and interferon beta-1b for mild to moderate disease. Also, dexamethasone significantly reduced mortality in those requiring respiratory support. However, there is still a great need for detailed level 1 evidence on pharmacologic therapies. url: https://api.elsevier.com/content/article/pii/S0735675720307853 doi: 10.1016/j.ajem.2020.08.091 id: cord-268211-egy8rgtl author: Barrasa, Helena title: SARS-Cov-2 in Spanish Intensive Care: Early Experience with 15-day Survival In Vitoria date: 2020-04-09 words: 2681.0 sentences: 181.0 pages: flesch: 53.0 cache: ./cache/cord-268211-egy8rgtl.txt txt: ./txt/cord-268211-egy8rgtl.txt summary: Methods: We identified patients from the two public hospitals in Vitoria who were admitted to ICU with confirmed infection by SARS-CoV-2. Conclusion: This early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring mechanical ventilation. Because of mortality reports in Wuhan [5] suggesting a close association, we assessed correlation between plasma procalcitonin at ICU admission and 7-day mortality. Our findings suggest that an oxygenation strategy emphasising optimisation of oxygenation, intubation based on clinical criteria of hyperventilation and avoiding ventilator-induced lung injury associated with non-invasive mechanical ventilation would be life-saving in a significant proportion of patients. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring prolonged mechanical ventilation. abstract: Abstract Purpose: Community transmission of SARS-CoV-2 was detected in Spain in February 2020, with 216% intensive care unit (ICU) capacity expanded in Vitoria by March 18th, 2020. Methods: We identified patients from the two public hospitals in Vitoria who were admitted to ICU with confirmed infection by SARS-CoV-2. Data reported here were available in March 31th, 2020. Mortality was assessed in those who completed 7-days of ICU stay. Results: We identified 48 patients (27 males) with confirmed SARS-CoV-2. Median [interquartile range (IQR)] age of patients was 63 [51-75] years. Symptoms began a median of 7 [5-12] days before ICU admission. The most common comorbidities identified were obesity (n = 48%), arterial hypertension (n = 44%) and chronic lung disease (n = 37%). All patients were admitted by hypoxemic respiratory failure and none received non-invasive mechanical ventilation. Forty-five (94%) underwent intubation, 3 HFNT, 1 (2%) extracorporeal membrane oxygenation (ECMO) and 22 (49%) required prone position. After 15 days, 14/45 (31%) intubated patients died (13% within one week), 10 (22%) were extubated, and 21/45 (47%) underwent mechanical ventilation. Six patients had documented co-infection. Procalcitonin plasma above 0.5 µg/L was associated with 16% vs. 19% (p = 0.78) risk of death after 7 days. Conclusion: This early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring mechanical ventilation. After 15 days of ICU admission, half of patients remained intubated, whereas one third died. url: https://doi.org/10.1016/j.accpm.2020.04.001 doi: 10.1016/j.accpm.2020.04.001 id: cord-031191-63xtga7h author: Barrios Espinosa, Cristian title: Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication date: 2020-08-06 words: 1819.0 sentences: 100.0 pages: flesch: 41.0 cache: ./cache/cord-031191-63xtga7h.txt txt: ./txt/cord-031191-63xtga7h.txt summary: title: Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication These devel-opments create opportunities for early detection of recurrent AF in patients with transitory AF events during acute illness or following non-cardiac surgery, enabling subsequent initiation of anticoagulation and other therapies. Patients without a history of AF and who reverted to sinus rhythm before discharge were included in the study and used a handheld single-lead ECG device for self-monitoring of AF recurrence 3 times per day for 4 weeks. [17] supports the notion that AF recurrence in patients with secondary AF in the setting of non-cardiac surgery or acute illness is common and has potentially important clinical consequences. Self-monitoring for atrial fibrillation recurrence in the discharge period post-cardiac surgery using an iPhone electrocardiogram Selfmonitoring for recurrence of secondary atrial fibrillation following noncardiac surgery or acute illness: a pilot study abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452374/ doi: 10.1016/j.ijcha.2020.100609 id: cord-309360-cpis1l4u author: Barrios-López, J. M. title: Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association? date: 2020-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Introduction Ischaemic stroke has been reported in patients with COVID-19, particularly in more severe cases. However, it is unclear to what extent this is linked to systemic inflammation and hypercoagulability secondary to the infection. Materials and methods We describe the cases of 4 patients with ischaemic stroke and COVID-19 who were attended at our hospital. Patients are classified according to the likelihood of a causal relationship between the hypercoagulable state and ischaemic stroke. We also conducted a review of studies addressing the possible mechanisms involved in the aetiopathogenesis of ischaemic stroke in these patients. Results The association between COVID-19 and stroke was probably causal in 2 patients, who presented cortical infarcts and had no relevant arterial or cardioembolic disease, but did show signs of hypercoagulability and systemic inflammation in laboratory analyses. The other 2 patients were of advanced age and presented cardioembolic ischaemic stroke; the association in these patients was probably incidental. Conclusions Systemic inflammation and the potential direct action of the virus may cause endothelial dysfunction, resulting in a hypercoagulable state that could be considered a potential cause of ischaemic stroke. However, stroke involves multiple pathophysiological mechanisms; studies with larger samples are therefore needed to confirm our hypothesis. The management protocol for patients with stroke and COVID-19 should include a complete aetiological study, with the appropriate safety precautions always being observed. url: https://api.elsevier.com/content/article/pii/S2173580820301012 doi: 10.1016/j.nrleng.2020.05.008 id: cord-016478-gpl0zbvd author: Barry, Maura title: Cytopenias in Transplant Patients date: 2018-12-08 words: 5636.0 sentences: 259.0 pages: flesch: 32.0 cache: ./cache/cord-016478-gpl0zbvd.txt txt: ./txt/cord-016478-gpl0zbvd.txt summary: The differential diagnosis for anemia after solid organ transplant includes hemolysis, drug toxicities, iron deficiency, infection, posttransplant lymphoproliferative disorder, graft-vs.-host disease, and hemophagocytic syndrome. Sirolimus and calcineurin inhibitors such as tacrolimus and cyclosporine have been shown in renal and lung transplant recipients to cause hemolytic anemia, thrombotic thrombocytopenic purpura, and atypical hemolytic uremic syndrome [15] [16] [17] . While this etiology is more often identified as a drug-related phenomenon, particularly due to the immunosuppressants required to prevent organ rejection (see next section), there have been multiple case reports associating CMV infection as a trigger of TMA in the posttransplant setting [53, 54] . When this is identified, numerous case studies in multiple different organ systems (lung, liver, kidney solid organ transplant) have reported that changing from one CI to another (tacrolimus to cyclosporine or vice versa) or to another class of medication such as sirolimus or mycophenolate mofetil can prevent further episodes of TMA from occurring [61] [62] [63] [64] . abstract: Anemia, leukopenia, thrombocytopenia, as well as pancytopenias can be seen following solid organ transplant. Varying patterns of cytopenia can be seen based on the drugs used in the posttransplant period, infections encountered by the individual, as well as the individual’s immune response and bone marrow function. The chapter discusses the main causes of anemia, leukopenia/neutropenia, and thrombocytopenia. The differential diagnosis for anemia after solid organ transplant includes hemolysis, drug toxicities, iron deficiency, infection, posttransplant lymphoproliferative disorder, graft-vs.-host disease, and hemophagocytic syndrome. Etiologies for leukopenia and neutropenia include drug toxicities and infection, and etiologies for thrombocytopenia include drug toxicities, infections, autoimmune events such as immune thrombocytopenic purpura, and underlying causes such as persistent portal hypertension and splenomegaly. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120766/ doi: 10.1007/978-1-4939-9034-4_10 id: cord-255519-tcobane8 author: Bartels, Matthew N. title: Acute Medical Conditions: Cardiopulmonary Disease, Medical Frailty, and Renal Failure date: 2020-10-02 words: 19990.0 sentences: 1027.0 pages: flesch: 33.0 cache: ./cache/cord-255519-tcobane8.txt txt: ./txt/cord-255519-tcobane8.txt summary: The population of patients who benefit from both cardiac and pulmonary rehabilitation is increasing as the population ages and heart disease remains a leading cause of global morbidity and mortality. Many patients with stroke, vascular disease, or other conditions can be included in active cardiac and pulmonary rehabilitation programs or benefit from the application of cardiopulmonary rehabilitation principles to their rehabilitation. For secondary prevention in patients with known cardiopulmonary disease, exercise should be at a safe level at 60% or more of the maximum heart rate to achieve a training effect. 82 Rehabilitation is focused on a program that resembles exercise for patients with heart failure, with the addition of close monitoring of oxygen saturation and the use of appropriate levels of supplemental oxygen to prevent hypoxemia. Individuals who are disabled tend to have lower activity levels, which puts them at increased risk of cardiac and pulmonary disease and may present obstacles for a standard rehabilitation program for a person who is newly disabled and who has preexisting cardiopulmonary limitations. abstract: Cardiopulmonary rehabilitation includes essential interventions that help patients maximize functional potential due to progressive deconditioning or acute decompensation following an acute medical event. The population of patients who benefit from both cardiac and pulmonary rehabilitation is increasing as the population ages and heart disease remains a leading cause of global morbidity and mortality. The principles of exercise physiology when applied to this population can reverse deconditioning, build cardiopulmonary reserve, and ultimately reduce morbidity and mortality in these populations. The physically disabled also benefit from exercise conditioning. The model of cardiac rehabilitation can also be applied to improve functional status of stroke patients, and this is an emerging area of interest supported by the shared pathophysiology and risk factors of cardiovascular conditions. The benefits of supervised exercise can also be extended to patients with clinically recognized frailty and post-transplant decline in function. Frailty is a complex diagnosis with multiple tools and approaches used to describe this syndrome. url: https://api.elsevier.com/content/article/pii/B9780323625395000278 doi: 10.1016/b978-0-323-62539-5.00027-8 id: cord-257696-ybu772zw author: Bartoletti, Michele title: Efficacy of corticosteroid treatment for hospitalized patients with severe COVID-19: a multicenter study date: 2020-09-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To assess the efficacy of corticosteroids in patients with coronavirus disease 2019 (COVID-19) METHODS: Multicenter observational study from February 22 through June 30, 2020. We included consecutive adult patients with severe COVID-19 defined as respiratory rate ≥30 breath per minute, oxygen saturation ≤93% on ambient air or arterial partial pressure of oxygen to fraction of inspired oxygen ≤300 mmHg. We excluded patients treated with other immunomodulant drugs, receiving low dose of corticosteroids and those receiving corticosteroids after 72h from admission. The primary endpoint was 30-day mortality form hospital admission. The main exposure variable was corticosteroid therapy at dosage of ≥0.5 mg/kg of prednisone equivalents. It was introduced as binomial covariate in a logistic regression model for primary endpoint and inverse probability of treatment weighting using the propensity score. RESULTS: Of 1717 patients with COVID-19 evaluated, 513 patients were included in the study; of these 170 (33%) were treated with corticosteroids. During the hospitalization 166 (34%) patients reached the primary outcome [60/170 (35%) in the corticosteroid group and 106/343 (31%) in the non-corticosteroid group]. At multivariable analysis corticosteroid treatment was not associated with lower 30-day mortality rate [aOR 0.59 (0.20-1.74), p=0.33]. After inverse probability of treatment weighting, corticosteroids were not associated to lower 30-day mortality [average treatment effect 0.05 (95% -0.02 to 0.09), p=0.12]. However, subgroup analysis revealed that in patients with PO(2)/FiO(2) < 200 mmHg at admission [135 patients, 52 (38%) treated with corticosteroids] corticosteroid treatment was associated to a lower risk of 30-day mortality [23/52 (44%) vs 45/83 (54%), aOR 0.20 (95%CI 0.04 to 0.90), p=0.036]. CONCLUSION: Our study shows that the effect of corticosteroid treatment on mortality might be limited to critically ill COVID-19 patients. url: https://api.elsevier.com/content/article/pii/S1198743X20305632 doi: 10.1016/j.cmi.2020.09.014 id: cord-326703-akn92p1r author: Bartoletti, Michele title: Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-Cov-2 infection: a multicenter cohort study (PREDI-CO study) date: 2020-08-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: We aimed to develop and validate a risk score to predict severe respiratory failure (SRF) among patients hospitalized with coronavirus disease-2019 (COVID-19). METHODS: We performed a multicentre cohort study among hospitalized (>24 hours) patients diagnosed with COVID-19 from February 22 to April 3 2020, at 11 Italian hospitals. Patients were divided into derivation and validation cohorts according to random sorting of hospitals. SRF was assessed from admission to hospital discharge and was defined as: SpO2<93% with 100% FiO2, respiratory rate (RR)>30bpm, or respiratory distress. Multivariable logistic regression models were built to identify predictors of SRF, β-coefficients were used to develop a risk score. Trial Registration NCT04316949. RESULTS: We analyzed 1113 patients (644 derivation, 469 validation cohort). Mean (±standard deviation)age was 65.7(±15) years, 704 (63.3%) were male. SRF occurred in 189/644 (29%) and 187/469 (40%) patients in derivation and validation cohort, respectively. At multivariate analysis, risk factors for SRF in the derivation cohort assessed at hospitalization were age ≥70 years [OR 2.74 (95%CI 1.66-4.50)], obesity [OR 4.62 (95%CI 2.78-7.70)], body temperature ≥38°C [OR 1.73 (95%CI 1.30-2.29)], RR ≥22bpm [OR 3.75 (95%CI 2.01-7.01)], lymphocytes ≤900/mm(3) [OR 2.69 (95%CI 1.60-4.51)], creatinine ≥1 mg/dl [OR 2.38 (95%CI 1.59-3.56)], C-reactive protein ≥10mg/dl [OR 5.91 (95%CI 4.88-7.17)], and lactate dehydrogenase ≥350IU/L[OR 2.39 (95%CI 1.11-5.11)]. Assigning points to each variable an individual risk score (PREDI-CO score) was obtained. Area under receiver-operator curve (AUROC) was 0.89 (0.86-0.92). At score of >3, sensitivity, specificity, positive and negative predictive values were 71.6%(65-79%), 89.1% (86-92%), 74%(67-80%), and 89%(85-91%), respectively;. PREDI-CO score showed similar prognostic ability in the validation cohort: AUROC 0.85 (0.81-0.88). At score of >3, sensitivity, specificity, positive and negative predictive values were 80% (73-85%), 76 (70-81%), 69%(60-74%) and 85% (80-89%), respectively. CONCLUSION: PREDI-CO score can be useful to allocate resources and prioritize treatments during COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32781244/ doi: 10.1016/j.cmi.2020.08.003 id: cord-340536-azlajqbe author: Bartolo, Michelangelo title: Urgent Measures for the Containment of the Coronavirus (Covid-19) Epidemic in the Neurorehabilitation/Rehabilitation Departments in the Phase of Maximum Expansion of the Epidemic date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 has rapidly become a pandemic emergency, distressing health systems in each affected country. COVID-19 determines the need for healthcare in a large number of people in an extremely short time and, like a tsunami wave, overruns emergency, infectious diseases, and pneumology departments as well as intensive care units, choking healthcare services. Rehabilitation services are also affected by this epidemic which forces radical changes both in the organization and in the operating methods. In the absence of reference literature on this issue, this report aims to provide a background documentation to support physicians and healthcare personnel involved in neurorehabilitation and rehabilitation care. url: https://doi.org/10.3389/fneur.2020.00423 doi: 10.3389/fneur.2020.00423 id: cord-341919-8gnthufw author: Basi, Saajan title: Clinical course of a 66-year-old man with an acute ischaemic stroke in the setting of a COVID-19 infection date: 2020-08-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A 66-year-old man was admitted to hospital with a right frontal cerebral infarct producing left-sided weakness and a deterioration in his speech pattern. The cerebral infarct was confirmed with CT imaging. The only evidence of respiratory symptoms on admission was a 2 L oxygen requirement, maintaining oxygen saturations between 88% and 92%. In a matter of hours this patient developed a greater oxygen requirement, alongside reduced levels of consciousness. A positive COVID-19 throat swab, in addition to bilateral pneumonia on chest X-ray and lymphopaenia in his blood tests, confirmed a diagnosis of COVID-19 pneumonia. A proactive decision was made involving the patients’ family, ward and intensive care healthcare staff, to not escalate care above a ward-based ceiling of care. The patient died 5 days following admission under the palliative care provided by the medical team. url: https://www.ncbi.nlm.nih.gov/pubmed/32843381/ doi: 10.1136/bcr-2020-235920 id: cord-290401-t87i3exo author: Bassetti, Matteo title: Principles of antimicrobial stewardship for bacterial and fungal infections in ICU date: 2017-09-12 words: 1638.0 sentences: 77.0 pages: flesch: 36.0 cache: ./cache/cord-290401-t87i3exo.txt txt: ./txt/cord-290401-t87i3exo.txt summary: Source control performed after 12 h was not associated with higher mortality, implying that in high-risk patients even beyond the 12-h timeframe from admission, it may contribute to improved outcomes [5] . In another Spanish retrospective cohort of intraabdominal candidiasis (IAC), source control along with early antifungal treatment was associated with improved survival in both ICU and surgical wards, standing out as the main goal for decreasing mortality of IAC episodes inside and outside the ICU [13] . Numerous studies have demonstrated that the delay of initiation of antifungal therapy was associated with significant increases in both in-hospital mortality and the cost of care for patients with IC [16] . Association between source control and mortality in 258 patients with intra-abdominal candidiasis: a retrospective multi-centric analysis comparing intensive care versus surgical wards in Spain abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/28900697/ doi: 10.1007/s00134-017-4922-x id: cord-263214-h6lkvlj3 author: Bassi, Massimiliano title: BEDSIDE TRANSCERVICAL-TRANSTRACHEAL POST-INTUBATION INJURY REPAIR IN A COVID-19 PATIENT date: 2020-04-22 words: 1319.0 sentences: 89.0 pages: flesch: 42.0 cache: ./cache/cord-263214-h6lkvlj3.txt txt: ./txt/cord-263214-h6lkvlj3.txt summary: title: BEDSIDE TRANSCERVICAL-TRANSTRACHEAL POST-INTUBATION INJURY REPAIR IN A COVID-19 PATIENT We report the case of a COVID-19 patient developing pneumomediastinum and subcutaneous emphysema secondary to post-intubation tracheal injury. We performed a bedside tracheal injury surgical repair, after failure of conservative management, with resolution of pneumomediastinum and subcutaneous emphysema and improvement of patient''s conditions. However, some patients need hospitalization for respiratory support and a relevant rate (ranging between 9.8 and 15.2%) requires oro-tracheal intubation (OTI) for invasive ventilation. We present a case of a COVID-19 patient who develops massive pneumomediastinum and subcutaneous emphysema for post-intubation tracheal injury. Considering the hemodynamic and respiratory instability after conservative management, a bedside surgical tracheostomy with primary suture of the tracheal lesion was performed. In order to reduce the risk of epidemic spread and avoid transporting, in absence of a COVID-19 dedicated operating room, the procedure was performed bedside. abstract: Abstract SARS-Co-2 disease 2019 (COVID-19) has rapidly spread worldwide since December 2019. A relevant rate of patients develops an acute respiratory distress syndrome that require hospitalization. Among them, a non-negligible rate (9.8%-15.2%) requires tracheal intubation for invasive ventilation. We report the case of a COVID-19 patient developing pneumomediastinum and subcutaneous emphysema secondary to post-intubation tracheal injury. The management of COVID-19 patient can be challenging due to the risk of disease transmission to caregivers and epidemic spread. We performed a bedside tracheal injury surgical repair, after failure of conservative management, with resolution of pneumomediastinum and subcutaneous emphysema and improvement of patient’s conditions. url: https://www.ncbi.nlm.nih.gov/pubmed/32333850/ doi: 10.1016/j.athoracsur.2020.04.009 id: cord-275742-7jxt6diq author: Batarseh, Feras A. title: Preventive healthcare policies in the US: solutions for disease management using Big Data Analytics date: 2020-06-23 words: 7208.0 sentences: 424.0 pages: flesch: 55.0 cache: ./cache/cord-275742-7jxt6diq.txt txt: ./txt/cord-275742-7jxt6diq.txt summary: Our work''s main objective (hypothesis) is two-tier: through one of the largest and most representative national health datasets for population-based surveillance, data imputations and machine learning models (such as clustering) offer preventive care pointers by grouping patients into heterogeneous clusters, and providing data-driven predictions and policies for healthcare in the US. The Center for Disease Control and Prevention (CDC) reported on those states, and presented multiple cases to help increase public trust in immunizations: "We hope this report is a reminder to healthcare professionals to make a strong vaccine recommendation to their patients at every visit and make sure parents understand how important it is for their children to get all their recommended vaccinations on time" [5, 8] . 2. We aim to collect more CDC data variables to provide more correlations and further tests for imputations, and compare with other NHANES predictive models for specific diseases such as periodontitis [39] . abstract: Data-driven healthcare policy discussions are gaining traction after the Covid-19 outbreak and ahead of the 2020 US presidential elections. The US has a hybrid healthcare structure; it is a system that does not provide universal coverage, albeit few years ago enacted a mandate (Affordable Care Act-ACA) that provides coverage for the majority of Americans. The US has the highest health expenditure per capita of all western and developed countries; however, most Americans don’t tap into the benefits of preventive healthcare. It is estimated that only 8% of Americans undergo routine preventive screenings. On a national level, very few states (15 out of the 50) have above-average preventive healthcare metrics. In literature, many studies focus on the cure of diseases (research areas such as drug discovery and disease prediction); whilst a minority have examined data-driven preventive measures—a matter that Americans and policy makers ought to place at the forefront of national issues. In this work, we present solutions for preventive practices and policies through Machine Learning (ML) methods. ML is morally neutral, it depends on the data that train the models; in this work, we make the case that Big Data is an imperative paradigm for healthcare. We examine disparities in clinical data for US patients by developing correlation and imputation methods for data completeness. Non-conventional patterns are identified. The data lifecycle followed is methodical and deliberate; 1000+ clinical, demographical, and laboratory variables are collected from the Centers for Disease Control and Prevention (CDC). Multiple statistical models are deployed (Pearson correlations, Cramer’s V, MICE, and ANOVA). Other unsupervised ML models are also examined (K-modes and K-prototypes for clustering). Through the results presented in the paper, pointers to preventive chronic disease tests are presented, and the models are tested and evaluated. url: https://www.ncbi.nlm.nih.gov/pubmed/32834926/ doi: 10.1186/s40537-020-00315-8 id: cord-296219-zzg9hds0 author: Battaglini, Denise title: Neurological Manifestations of Severe SARS-CoV-2 Infection: Potential Mechanisms and Implications of Individualized Mechanical Ventilation Settings date: 2020-08-12 words: 7486.0 sentences: 369.0 pages: flesch: 33.0 cache: ./cache/cord-296219-zzg9hds0.txt txt: ./txt/cord-296219-zzg9hds0.txt summary: Within this Abbreviations: ACE2, angiotensin-converting enzyme-2; ANE, acute necrotizing encephalopathy; ARDS, acute respiratory distress syndrome; BALF, bronchoalveolar lavage fluid; BBB, blood brain-barrier; CA, Ammon''s horn; CD, cluster of differentiation; CI, confidence interval; CNS, central nervous system; CoV, coronavirus; COVID-19, coronavirus disease 2019; CT, computed tomography; CXCR, chemokine receptor; DIC, disseminated intravascular coagulation; DO 2 , oxygen delivery; DPP4, dipeptidyl dipeptidase-4; ECMO, extracorporeal membrane oxygenation; FiO 2 fraction of inspired oxygen; FOX, forkhead box; HLH, hemophagocytic lymphohistiocytosis; ICAM, intracellular adhesion molecule; ICH, intracerebral hemorrhage; ICP, intracranial pressure; IFN, interferon; MERS, Middle East respiratory syndrome; MHV, mouse hepatitis virus; MRI, magnetic resonance images; nCoV, novel coronavirus; OR, odds ratio; PaCO 2 , partial pressure of carbon dioxide; PaO 2 partial pressure of oxygen; PbtO 2 brain tissue oxygenation tension; PCR, polymerase chain reaction; PEEP, positive end-expiratory pressure; PRES posterior reversible encephalopathy syndrome; RM, recruitment maneuvers; RNA, ribonucleic acid; SARS, severe acute respiratory syndrome; TLRs, toll-like receptor; TMPRSS2 transmembrane serine protease 2; TNF, tumor necrosis factor; WHO, World Health Organization. abstract: In December 2019, an outbreak of illness caused by a novel coronavirus (2019-nCoV, subsequently renamed SARS-CoV-2) was reported in Wuhan, China. Coronavirus disease 2019 (COVID-19) quickly spread worldwide to become a pandemic. Typical manifestations of COVID-19 include fever, dry cough, fatigue, and respiratory distress. In addition, both the central and peripheral nervous system can be affected by SARS-CoV-2 infection. These neurological changes may be caused by viral neurotropism, by a hyperinflammatory and hypercoagulative state, or even by mechanical ventilation-associated impairment. Hypoxia, endothelial cell damage, and the different impacts of different ventilatory strategies may all lead to increased stress and strain, potentially exacerbating the inflammatory response and leading to a complex interaction between the lungs and the brain. To date, no studies have taken into consideration the possible secondary effect of mechanical ventilation on brain recovery and outcomes. The aim of our review is to provide an updated overview of the potential pathogenic mechanisms of neurological manifestations in COVID-19, discuss the physiological issues related to brain-lung interactions, and propose strategies for optimization of respiratory support in critically ill patients with SARS-CoV-2 pneumonia. url: https://www.ncbi.nlm.nih.gov/pubmed/32903391/ doi: 10.3389/fneur.2020.00845 id: cord-336395-v157jzvv author: Battaglini, Denise title: Chest physiotherapy: an important adjuvant in critically ill mechanically ventilated patients with COVID-19 date: 2020-08-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In late 2019, an outbreak of a novel human coronavirus causing respiratory disease was identified in Wuhan, China. The virus spread rapidly worldwide, reaching pandemic status. Chest computed tomography scans of patients with coronavirus disease-2019 (COVID-19) have revealed different stages of respiratory involvement, with extremely variable lung presentations, which require individualized ventilatory strategies in those who become critically ill. Chest physiotherapy has proven to be effective for improving long-term respiratory physical function among ICU survivors. The ARIR recently reported the role of chest physiotherapy in the acute phase of COVID-19, pointing out limitation of some procedures due to the limited experience with this disease in the ICU setting. Evidence on the efficacy of chest physiotherapy in COVID-19 is still lacking. In this line, the current review discusses the important role of chest physiotherapy in critically ill mechanically ventilated patients with COVID-19, around the weaning process, and how it can be safely applied with careful organization, including the training of healthcare staff and the appropriate use of personal protective equipment to minimize the risk of viral exposure. url: https://api.elsevier.com/content/article/pii/S1569904820301877 doi: 10.1016/j.resp.2020.103529 id: cord-006460-3ayc0hne author: Baue, Arthur E. title: Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients date: 2000-10-19 words: 8379.0 sentences: 558.0 pages: flesch: 56.0 cache: ./cache/cord-006460-3ayc0hne.txt txt: ./txt/cord-006460-3ayc0hne.txt summary: Here, then, is an example of a Nobel Prize being awarded for the study of endothelial A.E. Baue ( ✉ ) cell-produced NO on the one hand, and the concept of excess vasodilatation in septic shock, the hypothesis that this was due to NO and a clinical trial blocking NO that increased mortality on the other. 3. We have tried to lump together and treat human abnormalities according to symptoms and signs rather than to the basic causes of their diseases -we have tried to treat inflammation, sepsis, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS) rather than what caused them; perforated diverticulitis is not acute pancreatitis and neither are ventilator-associated pneumonia and appendicitis. There has been significant improvement in survival of patients with persistent severe organ system failure." Thus, this report confirms again (1) that better intensive care is helping, and (2) my insistence that the secret to MOF is prevention. abstract: The excitement of molecular biology and of genetic knowledge and their possibilities must be balanced against our limitations in using this information for the care of our patients. There is a great discrepancy between what we know and what we can do. There are many reasons for this. A major one is that science must simplify/reduce the variables in experimentation and then generalize in terms of a specific factor or effect, whereas patients are complex with variables that we do not yet understand completely. This powerful science is now teaching us about the genetic diversity in both susceptibility and outcome of disease, and the diversity in life experiences and antigen exposures. Clinicians have tried to lump together and treat in a similar way many diverse human diseases. This has not worked well. Pancreatitis and perforated diverticulitis both produce inflammation and sepsis, but they are different processes and may both lead to multiple organ failure. This lumping together has contributed to the failure of so-called magic bullets. There are new contributors to organ damage. Gender, lifestyle and prior disease differences also complicate the care of patients. Despite this, we are slowly and gradually improving the care of our surgical patients by careful pre-, intra- and postoperative support and better, simpler and safer operations. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101854/ doi: 10.1007/s004230000162 id: cord-257729-s0vo7dlk author: Bauer, Melissa title: Obstetric Anesthesia During the Coronavirus Disease 2019 Pandemic date: 2020-04-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: With increasing numbers of Coronavirus Disease 2019 (COVID19) cases due to efficient human-to-human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States, preparation for the unpredictable setting of labor and delivery is paramount. The priorities are 2-fold in the management of obstetric patients with COVID-19 infection or persons under investigation (PUI): (1) caring for the range of asymptomatic to critically ill pregnant and postpartum women; (2) protecting health care workers and beyond from exposure during the delivery hospitalization (health care providers, personnel, family members). The goal of this review is to provide evidence-based recommendations or, when evidence is limited, expert opinion for anesthesiologists caring for pregnant women during the COVID19 pandemic with a focus on preparedness and best clinical obstetric anesthesia practice. url: https://doi.org/10.1213/ane.0000000000004856 doi: 10.1213/ane.0000000000004856 id: cord-280794-k591vqji author: Bauer, Melissa E. title: Neuraxial Procedures in COVID-19–Positive Parturients: A Review of Current Reports date: 2020-04-20 words: 837.0 sentences: 59.0 pages: flesch: 43.0 cache: ./cache/cord-280794-k591vqji.txt txt: ./txt/cord-280794-k591vqji.txt summary: Because anesthesiologists must take into account the risk of meningitis or encephalitis associated with neuraxial procedures in the setting of untreated viremia, we reviewed publications reporting outcomes in COVID-19-positive pregnant women in the current pandemic in an attempt to address this concern. In general, the risk of causing meningitis or encephalitis is extremely low with neuraxial procedures, even in infected patients. Before performing a neuraxial procedure in these patients, it would be advisable to review a recent platelet count given that one-third of patients with COVID-19 infection have been reported to have thrombocytopenia compared with 7%-12% of patients during pregnancy alone. 7 In pregnant women, a platelet count of 70,000 × 10 6 /L has a low risk for spinal epidural hematoma, and lower levels should be considered in cases such as these with a high risk for respiratory compromise with general anesthesia. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32221171/ doi: 10.1213/ane.0000000000004831 id: cord-006464-s8rjoyse author: Bauer, Michael title: Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome date: 2015-02-27 words: 5413.0 sentences: 279.0 pages: flesch: 44.0 cache: ./cache/cord-006464-s8rjoyse.txt txt: ./txt/cord-006464-s8rjoyse.txt summary: Our data for the first time show systematically that increased susceptibility to infections in MECP2 duplication syndrome is associated with IgA/IgG(2)-deficiency, low antibody titers against pneumococci and elevated acute-phase responses. The single patient who has to date not developed severe infections despite We further investigated whether patients with MECP2 duplication syndrome showed stronger acute phase responses, which we could confirm in 7/10 patients in terms of elevated CRP values above 200 mg/l during non-invasive infections, mainly pneumoniae. In summary we here show for the first time systematically that patients with MECP2 duplication syndrome are at increased risk for in particular non-invasive but also for invasive infections with potentially encapsulated bacteria, that this increased susceptibility to infections may be associated with IgG 2 -subclass deficiency/ low titers against pneumococci and elevated acute-phase responses, while the precise role of T-cell immunity and in particular the extent of impaired IFNγsecretion and its role for the observed infectious phenotype is still to be defined. abstract: MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting an additional immunodeficiency. We describe for the first time the detailed infectious and immunological phenotype of MECP2 duplication syndrome. 17/27 analyzed patients suffered from pneumonia, 5/27 from at least one episode of sepsis. Encapsulated bacteria (S.pneumoniae, H.influenzae) were frequently isolated. T-cell immunity showed no gross abnormalities in 14/14 patients and IFNy-secretion upon ConA-stimulation was not decreased in 6/7 patients. In 6/21 patients IgG(2)-deficiency was detected – in 4/21 patients accompanied by IgA-deficiency, 10/21 patients showed low antibody titers against pneumococci. Supra-normal IgG(1)-levels were detected in 11/21 patients and supra-normal IgG(3)-levels were seen in 8/21 patients – in 6 of the patients as combined elevation of IgG(1) and IgG(3). Three of the four patients with IgA/IgG(2)-deficiency developed multiple severe infections. Upon infections pronounced acute-phase responses were common: 7/10 patients showed CRP values above 200 mg/l. Our data for the first time show systematically that increased susceptibility to infections in MECP2 duplication syndrome is associated with IgA/IgG(2)-deficiency, low antibody titers against pneumococci and elevated acute-phase responses. So patients with MECP2 duplication syndrome and low IgA/IgG(2) may benefit from prophylactic substitution of sIgA and IgG. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10875-015-0129-5) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101860/ doi: 10.1007/s10875-015-0129-5 id: cord-275913-85u6v3ib author: Bauernschmitt, Robert title: Valve-in-valve transcatheter aortic valve replacement in a young patient with a suspected COVID-19 infection: a surgical dilemma in the era of the COVID-19 pandemic date: 2020-06-08 words: 1076.0 sentences: 55.0 pages: flesch: 43.0 cache: ./cache/cord-275913-85u6v3ib.txt txt: ./txt/cord-275913-85u6v3ib.txt summary: On admission, the patient underwent a computed tomography scan which demonstrated interstitial infiltration in the left lung, highly suspicious for a COVID-19 infection that could not be confirmed by reverse transcription polymerase chain reaction (RT-PCR) testing. We decided to perform transcatheter aortic valve replacement to avoid cardiopulmonary bypass with shorter operative times, presumably shorter ventilation times and duration of intensive care unit stay, and thus a lesser risk for pulmonary complications. Following discussion in the local heart team and with the consent of the patient, we decided to perform valve-in-valve transcatheter aortic valve replacement (TAVR) to prevent the potential complications of a prolonged reroot-replacement with its long operative and cardiopulmonary bypass times, which could lead to an increased time on the respirator in the ICU. Figure 1: Computed tomography scan on admission with interstitial infiltration highly suspicious for a COVID-19 infection. abstract: We report on a case of a 57-year-old male patient, who underwent full root replacement in 2005 and now presented with high grade aortic insufficiency. On admission, the patient underwent a computed tomography scan which demonstrated interstitial infiltration in the left lung, highly suspicious for a COVID-19 infection that could not be confirmed by reverse transcription polymerase chain reaction (RT-PCR) testing. As there usually is a delay between infection and positive RT-PCR test results, the initial decision was to perform additional testing. However, the patient deteriorated quickly in spite of optimal medical therapy making urgent aortic valve replacement necessary. We decided to perform transcatheter aortic valve replacement to avoid cardiopulmonary bypass with shorter operative times, presumably shorter ventilation times and duration of intensive care unit stay, and thus a lesser risk for pulmonary complications. url: https://www.ncbi.nlm.nih.gov/pubmed/32510155/ doi: 10.1093/ejcts/ezaa193 id: cord-273602-cq276tj8 author: Bavishi, Chirag title: Acute myocardial injury in patients hospitalized with COVID-19 infection: A review date: 2020-06-06 words: 2116.0 sentences: 123.0 pages: flesch: 39.0 cache: ./cache/cord-273602-cq276tj8.txt txt: ./txt/cord-273602-cq276tj8.txt summary: Randomized trials are urgently needed to investigate treatment modalities to reduce the incidence and mortality associated with COVID-19 related acute myocardial injury. In this concise review, we will focus on acute myocardial injury in COVID-19 infection, its prevalence, plausible pathophysiologic mechanisms, guidance on the use of cardiac biomarkers, and general management strategies. In a prospective cohort study by Du et al(11) of 179 patients with COVID-19 pneumonia, troponin I ≥0.05 ng/mL was independently associated with mortality in addition to age ≥65 years, pre-existing cardiovascular (CV) or cerebrovascular diseases and CD3+CD8+ Tcells ≤75 cells/μL. Epidemiological studies and randomized trials are urgently needed to investigate treatment modalities regulating immune function and inhibiting inflammatory responses to reduce the incidence and mortality associated with COVID-19 related acute myocardial injury. Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality abstract: The Coronavirus Disease 2019 (COVID-19) is now a global pandemic with millions affected and millions more at risk for contracting the infection. The COVID-19 virus, SARS-CoV-2, affects multiple organ systems particularly the lungs and heart. Elevation of cardiac biomarkers, particularly high-sensitivity troponin and/or creatine kinase MB, is common in patients with COVID-19 infection. In our review of clinical studies, we found that in 26 studies including 11,685 patients, the weighted pooled prevalence of acute myocardial injury was 20% (ranged from 5% to 38% depending on the criteria used). The plausible mechanisms of myocardial injury include, 1) hyperinflammation and cytokine storm mediated through pathologic T-cells and monocytes leading to myocarditis, 2) respiratory failure and hypoxemia resulting in damage to cardiac myocytes, 3) down regulation of ACE2 expression and subsequent protective signaling pathways in cardiac myocytes, 4) hypercoagulability and development of coronary microvascular thrombosis, 5) diffuse endothelial injury and ‘endotheliitis’ in several organs including heart, and, 6) inflammation and/or stress causing coronary plaque rupture or supply-demand mismatch leading to myocardial ischemia/infarction. Cardiac biomarkers can be used to aid in diagnosis as well as risk stratification. In patients with elevated hs-troponin, clinical context is important and myocarditis as well as stress induced cardiomyopathy should be considered in the differential, along with type I and type II myocardial infarction. Irrespective of etiology, patients with acute myocardial injury should be prioritized for treatment. Clinical decisions including interventions should be individualized and carefully tailored after thorough review of risks/benefits. Given the complex interplay of SARS-CoV-2 with the cardiovascular system, further investigation into potential mechanisms is needed to guide effective therapies. Randomized trials are urgently needed to investigate treatment modalities to reduce the incidence and mortality associated with COVID-19 related acute myocardial injury. url: https://www.sciencedirect.com/science/article/pii/S0033062020301237?v=s5 doi: 10.1016/j.pcad.2020.05.013 id: cord-004646-zhessjqh author: Bawazeer, Mohammed title: Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial date: 2020-03-20 words: 7841.0 sentences: 381.0 pages: flesch: 42.0 cache: ./cache/cord-004646-zhessjqh.txt txt: ./txt/cord-004646-zhessjqh.txt summary: title: Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial The 2018 Pain, Agitation/sedation, Delirium, Immobility, and Sleep disruption guideline suggested low-dose ketamine infusion as an adjunct to opioid therapy to reduce opioid requirements in post-surgical patients in the intensive care unit (ICU). Therefore, we propose a prospective, randomized, active controlled, open-label, pilot, feasibility study to assess the effect and safety of Analgo-sedative ad-juncT keTAmine Infusion iN Mechanically vENTilated ICU patients (the ATTAINMENT trial) compared to standard of care alone. Physician decline after randomization Ketamine will be discontinued Subject will be included in the data analysis a In cases of death (either within the first 48 h, until ICU or hospital discharge, or 28 days after randomization, whichever comes first), detailed documentation will be carried out in the medical record for the cause of death, group allocation, and relation to study protocol allocation and initiation of the trial intervention. abstract: BACKGROUND: A noticeable interest in ketamine infusion for sedation management has developed among critical care physicians for critically ill patients. The 2018 Pain, Agitation/sedation, Delirium, Immobility, and Sleep disruption guideline suggested low-dose ketamine infusion as an adjunct to opioid therapy to reduce opioid requirements in post-surgical patients in the intensive care unit (ICU). This was, however, rated as conditional due to the very low quality of evidence. Ketamine has favorable characteristics, making it an especially viable alternative for patients with respiratory and hemodynamic instability. The Analgo-sedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU patients (ATTAINMENT) trial aims to assess the effect and safety of adjunct low-dose continuous infusion of ketamine as an analgo-sedative compared to standard of care in critically ill patients on mechanical ventilation (MV) for ≥ 24 h. METHODS/DESIGN: This trial is a prospective, randomized, active controlled, open-label, pilot, feasibility study of adult ICU patients (> 14 years old) on MV. The study will take place in the adult ICUs in the King Faisal Specialist Hospital and Research Center (KFSH&RC), Riyadh, Saudi Arabia, and will enroll 80 patients. Patients will be randomized post-intubation into two groups: the intervention group will receive an adjunct low-dose continuous infusion of ketamine plus standard of care. Ketamine will be administered over a period of 48 h at a fixed infusion rate of 2 μg/kg/min (0.12 mg/kg/h) in the first 24 h followed by 1 μg/kg/min (0.06 mg/kg/h) in the second 24 h. The control group will receive standard of care in the ICU (propofol and/or fentanyl and/or midazolam) according to the KFSH&RC sedation and analgesia protocol as clinically appropriate. The primary outcome is MV duration until ICU discharge, death, extubation, or 28 days post-randomization, whichever comes first. DISCUSSION: The first patient was enrolled on 1 September 2019. As of 10 October 2019, a total of 16 patients had been enrolled. We expect to complete the recruitment by 31 December 2020. The findings of this pilot trial will likely justify further investigation for the role of adjunct low-dose ketamine infusion as an analgo-sedative agent in a larger, multicenter, randomized controlled trial. TRIAL REGISTRATION: ClinicalTrials.gov: NCT04075006. Registered on 30 August 2019. Current controlled trials: ISRCTN14730035. Registered on 3 February 2020. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085173/ doi: 10.1186/s13063-020-4216-4 id: cord-261151-27ocvgnw author: Becker, Jessica E. title: Pediatric Consultation-Liaison Psychiatry: An Update and Review date: 2020-04-25 words: 8048.0 sentences: 425.0 pages: flesch: 34.0 cache: ./cache/cord-261151-27ocvgnw.txt txt: ./txt/cord-261151-27ocvgnw.txt summary: Moreover, much like in adult C-L psychiatry, these services can assist medical teams in managing the acute onset of neuropsychiatric disease, including delirium and catatonia, as well as help to identify and treat psychiatric symptoms and sequelae of systemic illnesses and treatments. 2 The survey results highlighted the most common reasons for pediatric psychiatric consultation to include suicide risk assessment, assistance in the diagnosis and management of medically unexplained symptoms, adjustment to medical illness, assessment for psychopharmacologic intervention, delirium, treatment non-adherence, and the management of children admitted to pediatric units to await psychiatric hospital placement (boarding). 27 Though often under-recognized, pediatric delirium is a common problem, present in at least 20-25% of critically ill patients, 28 and is associated with increased cost of care, 29 length of hospitalization, 30 mortality rate, 31 and the risk of future development of post-traumatic stress disorder symptoms for both patients and their families. abstract: BACKGROUND: In recent years, there has been an increasing burden of child and adolescent mental illness recognized in the United States, and the need for pediatric mental health care is growing. Pediatric consultation-liaison psychiatrists are increasingly playing a role in the management of medical and psychiatric disease for pediatric patients. The field is a fast-moving one, with understanding of new neuropsychiatric disease entities; reformulation of prior disease entities; and new, interdisciplinary treatments and models of care. METHODS: In this study, we aim to review recent advances in the field of pediatric consultation-liaison psychiatry, including new diagnostic entities, updated management of frequently encountered clinical presentations, and developments in systems of care. CONCLUSION: The advances in pediatric consultation-liaison psychiatry are broad and serve to promote more streamlined, evidence-based care for the vulnerable population of psychiatrically ill pediatric medical patients. More work remains to determine the most effective interventions for the wide array of presentations seen by pediatric consultation-liaison psychiatrists. url: https://doi.org/10.1016/j.psym.2020.04.015 doi: 10.1016/j.psym.2020.04.015 id: cord-311730-189vax2m author: Becker, Richard C. title: Covid-19 treatment update: follow the scientific evidence date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32338320/ doi: 10.1007/s11239-020-02120-9 id: cord-006181-fkh2fzbr author: Bednarczyk, Joseph M. title: Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date: 2015-04-08 words: 3529.0 sentences: 232.0 pages: flesch: 42.0 cache: ./cache/cord-006181-fkh2fzbr.txt txt: ./txt/cord-006181-fkh2fzbr.txt summary: This report describes the clinical course of four consecutive patients with blastomycosis-related ARDS treated with venovenous extracorporeal membrane oxygenation (ECMO) during 2009-2014. 3 Venovenous extracorporeal membrane oxygenation (ECMO) has been utilized for the management of severe ARDS to facilitate gas exchange, allow lung rest by deescalation of ventilatory support, and provide time for resolution of the underlying disease. 7 Extracorporeal membrane oxygenation is generally considered in ARDS patients with refractory hypoxemia or hypercapnia despite a lung protective ventilation strategy or in those where the maintenance of adequate gas exchange requires potentially injurious applied volumes or pressures. Extracorporeal membrane oxygenation may be an effective treatment modality for patients with blastomycosis-related ARDS and refractory hypoxemia despite optimal mechanical ventilation. Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) in fulminant blastomycosis in Germany abstract: PURPOSE: Blastomyces dermatitidis is a dimorphic fungus endemic to North America capable of causing fatal respiratory failure. Acute respiratory distress syndrome (ARDS) complicates up to 10% of pulmonary blastomycosis in hospitalized patients and carries a mortality of 50-90%. This report describes the clinical course of four consecutive patients with blastomycosis-related ARDS treated with venovenous extracorporeal membrane oxygenation (ECMO) during 2009-2014. CLINICAL FEATURES: Four adults were referred from northwestern Ontario, Canada with progressive respiratory illnesses. All patients developed diffuse bilateral opacities on chest radiography and required mechanical ventilation within 6-72 hr. Patients satisfied Berlin criteria for severe ARDS with trough P(a)O(2)/F(i)O(2) ratios of 44-61 on positive end-expiratory pressure of 12-24 cm H(2)O. Wet mount microscopy from respiratory samples showed broad-based yeast consistent with B.dermatitidis. Despite lung protective ventilation strategies with maximal F(i)O(2) (patients A-D), neuromuscular blockade (patients A-D), inhaled nitric oxide (patients A and D), and prone positioning (patient D), progressive hypoxemia resulted in initiation of venovenous ECMO by hours 24-90 of mechanical ventilation with subsequent de-escalation of ventilatory support. In all four cases, ECMO decannulation was performed (7-23 days), mechanical ventilation was withdrawn (18-52 days), and the patients survived to hospital discharge (31-87 days). CONCLUSION: This report describes the successful application of ECMO as rescue therapy in aid of four patients with refractory blastomycosis-associated ARDS. In addition to early appropriate antimicrobial therapy, transfer to an institution experienced with ECMO should be considered when caring for patients from endemic areas with rapidly progressive respiratory failure. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100112/ doi: 10.1007/s12630-015-0378-z id: cord-276495-q22jnkn2 author: Belizário, José Ernesto title: Trained innate immunity, COVID-19 therapeutic dilemma, and fake science date: 2020-07-06 words: 2769.0 sentences: 132.0 pages: flesch: 44.0 cache: ./cache/cord-276495-q22jnkn2.txt txt: ./txt/cord-276495-q22jnkn2.txt summary: This type of immunological memory or epigenetic programming to a pre-activated state allows the generation of a sustained and more effective non-specific response, even after years, although in the protocols of these studies, the innate immunity was evaluated after 3 months (2). Various clinical trials are underway to evaluate trained immunity through BCG vaccination in healthy volunteers under the coordination of Dr. Mihail Netea (Radboud University Medical Center, Nijmegen, the Netherlands). To our knowledge, there are no published articles or clinical evidences that show that BCG immunization protects against SARS-CoV-2 in Brazil. The journal The Lancet, in May 2020, published the results of an observational, longitudinal, and retrospective clinical study based on medical records of COVID-19 patient cohorts treated across 6 countries and 671 hospitals, with different technical capabilities and diverse drug protocols (13) . abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32667492/ doi: 10.6061/clinics/2020/e2124 id: cord-328513-81yvcgul author: Bellastella, Giuseppe title: Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects date: 2016-08-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: This publication reviews the accepted knowledges and the findings still discussed on several features of autoimmune hypophysitis, including the most recently described forms, such as IgG4 and cancer immunotherapy- related hypophysitis. METHODS: The most characteristic findings and the pending controversies were derived from a literature review and previous personal experiences. A single paragraph focused on some atypical examples of the disease presenting under confounding pretences. RESULTS: Headache, visual field alterations and impaired pituitary secretion are the most frequent clinical findings of the disease. Pituitary biopsy, still considered the gold diagnostic standard, does not always receive consent from the patients. The role of magnetic resonance imaging is limited, as this disease may generate images similar to those of other diseases. The role of antipituitary and antihypothalamus antibodies is still discussed owing to methodological difficulties and also because the findings on the true pituitary antigen(s) are still debated. However, the low sensitivity and specificity of immunofluorescence, one of the more widely employed methods to detect these antibodies, may be improved, considering a predetermined cut-off titre and a particular kind of immunostaining. CONCLUSION: Autoimmune hypophysitis is a multifaceted disease, which may certainly be diagnosed by pituitary biopsy. However, the possible different clinical, laboratory and imaging features must be considered by the physician to avoid a misdiagnosis when examining a possibly affected patient. Therapeutic choice has to be made taking into account the clinical conditions and the degree of hypothalamic-pituitary involvement, but also considering that spontaneous remissions can occur. url: https://www.ncbi.nlm.nih.gov/pubmed/27503372/ doi: 10.1007/s11102-016-0736-z id: cord-016460-39yniw0t author: Ben-Chetrit, Eldad title: Colchicine date: 2018-07-31 words: 9575.0 sentences: 532.0 pages: flesch: 45.0 cache: ./cache/cord-016460-39yniw0t.txt txt: ./txt/cord-016460-39yniw0t.txt summary: • Rat sarcoma homolog gene family, member A (Rho A) protein is a peptide which controls the action of GTPases thereby affects tubulin dynamics • Pyrin is a specific immune sensor (pattern recognition receptor-PRR) for bacterial modifications of Rho and GTPases • Activation of RhoA inhibits pyrin activity while inactivation of RhoA causes over activation of pyrin resulting in increased production of interleukin (IL)-1, thereby enhancing inflammation • Colchicine may activate RhoA by guanine nucleotide exchange factor (GEF)-H1, thereby suppressing pyrin activity and inflammation • Colchicine also disrupts microtubules structure reducing neutrophils membrane elasticity and relaxation, thereby preventing their extravasation from the blood vessels to the inflammatory site abstract: Colchicine is an alkaloid which was originally extracted from bulbs of a plant called Colchicum autumnale (meadow saffron). Its active pharmacological component was isolated in 1820 and in 1833 the active ingredient was purified and named colchicine. It consists of three hexameric rings termed A, B, and C. It was first recommended for the treatment of gout by Alexander of Tralles in the sixth century AD. Later it has been employed for suggested and approved indications including primary biliary cirrhosis (PBC), alcohol induced hepatitis, psoriasis, Behçet disease, Sweet syndrome, scleroderma, sarcoidosis and amyloidosis. Perhaps the most effective results have been obtained in the prophylaxis of familial Mediterranean fever (FMF). Colchicine is absorbed in the jejunum and ileum and is trapped in the body tissues. It is metabolized in the liver and the intestine by cytochrome P (CYP) 450 3A4 and P-glycoprotein (PGY) 1. Colchicine is excreted mainly by the biliary system, intestines and the kidneys. It has a narrow therapeutic range, but with normal liver and kidney functions is relatively safe and can be used during pregnancy, nursing and in infants. The main mechanism of action of colchicine is probably through interaction with microtubules affecting leukocyte chemotaxis, thereby suppressing inflammation. The blood level of colchicine may be affected by concomitant drug administration and therefore, caution should be exercised when such medications are added. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120738/ doi: 10.1007/978-3-319-98605-0_40 id: cord-272143-6ej3eibd author: Benavides‐Nieto, Marta title: The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy date: 2018-12-21 words: 1875.0 sentences: 133.0 pages: flesch: 40.0 cache: ./cache/cord-272143-6ej3eibd.txt txt: ./txt/cord-272143-6ej3eibd.txt summary: We have evaluated these infections in children with humoral immunodeficiencies who required immunoglobulin replacement therapy, considering their relationship with symptoms, lung function, bacterial co‐infection, and outcomes. CONCLUSIONS: In our experience, viral respiratory tract infections can cause significant respiratory symptoms and impaired lung function, in children with HID, despite immunoglobulin replacement therapy. Children with severe T-cell immunodeficiencies present impaired clearance of respiratory viruses, and pulmonary complications of viral infections are leading causes of morbidity and mortality in this group of patients. 1 However, the role of respiratory viruses in children with other types of primary immunodeficiency (PID), mainly those with humoral immunodeficiencies (HID) or diseases of immune dysregulation, has hardly been studied. 2, 7 We report, to the best of our knowledge, the first study that analyses respiratory viruses in pediatric patients with predominantly antibody deficiency who required IRT, considering their relationship with clinical symptoms and pulmonary function, bacterial co-infection, treatment and outcomes. abstract: BACKGROUND: The role of viruses in children with respiratory tract infections and humoral immunodeficiencies has hardly been studied. We have evaluated these infections in children with humoral immunodeficiencies who required immunoglobulin replacement therapy, considering their relationship with symptoms, lung function, bacterial co‐infection, and outcomes. METHODS: We conducted a prospective case‐control study during a 1‐year period, including children with humoral immunodeficiencies receiving immunoglobulin replacement therapy. For each patient, at least one healthy family member was included. Respiratory samples for viral detection were taken every 1‐3 months, and in case of respiratory tract infections. Symptoms questionnaires were filled biweekly. Spirometry and sputum culture were performed in every episode. RESULTS: Sixty‐six episodes were analyzed in 14 patients (median age 12 years; IQR 7‐17), identifying 18 respiratory viruses (27.3%), being rhinovirus the most frequently isolated one (12/18; 66%). Positive viral episodes were associated with clinical symptoms (89% vs 43%), more frequent antibiotic treatment (44% vs 15%) or hospital admission (22% vs 0%) than negative ones. Patients with positive viral detection showed impaired lung function, with lower FEV1 and FVC values. CONCLUSIONS: In our experience, viral respiratory tract infections can cause significant respiratory symptoms and impaired lung function, in children with HID, despite immunoglobulin replacement therapy. These patients could benefit from the monitoring of viral infections, as these may be a gateway for ongoing lung damage. url: https://www.ncbi.nlm.nih.gov/pubmed/30575324/ doi: 10.1002/ppul.24214 id: cord-327413-zdbnoy1q author: Bendjelid, Karim title: Hemodynamic monitoring of Covid-19 patients. Classical methods and new paradigms date: 2020-09-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S235255682030179X?v=s5 doi: 10.1016/j.accpm.2020.09.001 id: cord-004096-obrq7q57 author: Benghanem, Sarah title: Brainstem dysfunction in critically ill patients date: 2020-01-06 words: 5804.0 sentences: 315.0 pages: flesch: 36.0 cache: ./cache/cord-004096-obrq7q57.txt txt: ./txt/cord-004096-obrq7q57.txt summary: OCR: oculocephalic reflex BRASS is a clinical score that has been developed for scoring brainstem dysfunction in deeply sedated, non-brain-injured, mechanically ventilated, critically ill patients and ranges from 0 to 7 The BRASS has prognostic value, as 28-day mortality proportionally increases with the BRASS score applicable to ICU patients. The "brainstem dysfunction" hypothesis originates from our study on usefulness of neurological examination in non-brain-injured critically ill patients who required deep sedation. In deeply sedated non-brain-injured critically ill patients, the cessation of brainstem responses follows two distinct patterns. Middle latency BAEP responses and SSEP latencies were increased in 24% and 45% of deeply sedated non-brain-injured critically ill patients, respectively [34] , indicating an impairment of the brainstem conduction. Brainstem dysfunction can present with central sensory and motor deficits, cranial nerve palsies and abnormal brainstem reflexes, disorders of consciousness, respiratory failure, and dysautonomia. abstract: The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. It controls the sleep-wake cycle and vital functions via the ascending reticular activating system and the autonomic nuclei, respectively. Brainstem dysfunction may lead to sensory and motor deficits, cranial nerve palsies, impairment of consciousness, dysautonomia, and respiratory failure. The brainstem is prone to various primary and secondary insults, resulting in acute or chronic dysfunction. Of particular importance for characterizing brainstem dysfunction and identifying the underlying etiology are a detailed clinical examination, MRI, neurophysiologic tests such as brainstem auditory evoked potentials, and an analysis of the cerebrospinal fluid. Detection of brainstem dysfunction is challenging but of utmost importance in comatose and deeply sedated patients both to guide therapy and to support outcome prediction. In the present review, we summarize the neuroanatomy, clinical syndromes, and diagnostic techniques of critical illness-associated brainstem dysfunction for the critical care setting. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945639/ doi: 10.1186/s13054-019-2718-9 id: cord-006332-ikh45wuy author: Bengmark, Stig title: Nutritional Support to Prevent and Treat Multiple Organ Failure date: 1996 words: 6918.0 sentences: 433.0 pages: flesch: 44.0 cache: ./cache/cord-006332-ikh45wuy.txt txt: ./txt/cord-006332-ikh45wuy.txt summary: Probiotic bacteria have several important functions in the colon: (1) production of nutrients for the mucosa: acetate, butyrate, propionate, other SCFAs, pyruvate, lactate, and amino acids (arginine, cysteine, glutamine); (2) production of micronutrients (␤ group and folic acid, antioxidants, and polyamines), histamine, 5-hydroxytryptamine, piperidine, tyramine, cadaverine, pyrrolidine, agmatine, putrescine; (3) prevention of overgrowth of PPMs; (4) stimulation of the immune system, especially the gut-associated lymphoid tissue (GALT) system: NO is produced by these bacteria in the mouth and GI tract; (5) elimination of toxins from the lumen; (6) participation in intestinal regulation, mucus utilization, nutrient absorption, GI motility, and blood flow through signaling substances such as NO. Studies of abilities of lactobacilli to ferment fiber in vitro, to survive the acidity of stomach and the bile acid contents of the small intestine, to adhere to the colonic mucosa, and to remain and function there after the supply stopped led us to identify a few human lactobacilli with great capability. abstract: Pseudomonas . Food antioxidants such as glutathione, vitamin E, and β-carotenes are important. Ingredients for the colonic mucosa are important. Approximately 10% of caloric need is satisfied by so-called colonic food (prebiotics), fermented at the level of the colonic mucosa to produce colonic mucosa nutrients and to prevent gut origin sepsis. More than 10 g of fiber per day is recommended. The fermenting flora (probiotic flora) is deranged owing to disease or antibiotic treatment, and resupply of flora is important. A new concept of ecoimmune nutrition is presented for enteral supply of mucosa-reconditioning ingredients: new surfactants, pseudomucus, fiber, amino acids such as arginine, and mucosa-adhering Lactobacillus plantarum 299. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101626/ doi: 10.1007/s002689900075 id: cord-272630-2na1gndu author: Benito, Daniel A. title: Local spikes in COVID-19 cases: Recommendations for maintaining otolaryngology clinic operations date: 2020-08-20 words: 2089.0 sentences: 132.0 pages: flesch: 48.0 cache: ./cache/cord-272630-2na1gndu.txt txt: ./txt/cord-272630-2na1gndu.txt summary: The Coronavirus Disease-2019 (COVID-19) pandemic has created an unprecedented economic and public health crisis in the United States. As healthcare system strain became imminent, the Centers for Medicare and Medicaid Services (CMS) 3 , the Surgeon General, and the American College of Surgeons (ACS) [4] recommended postponing elective procedures in efforts to mitigate the spread of disease and preserve personal protective equipment (PPE). [12] In addition, patients who may require office-based procedures should be screened and should be strongly considered to undergo COVID-19 testing prior to arrival, if possible ( Table 2 ). In-person examinations pose obvious risks of SARS-CoV2 (novel coronavirus) transmission among patients, family and friends of patients, and clinical staff. High-Risk Aerosol Generating Procedures in COVID-19: Respiratory Protective Equipment Considerations. Protecting patients and healthcare personnel from COVID-19: considerations for practice and outpatient care in cardiology How to train health personnel to protect themselves from SARS-CoV-2 (novel coronavirus) infection when caring for a patient or suspected case abstract: The Coronavirus Disease-2019 (COVID-19) pandemic has created an unprecedented economic and public health crisis in the United States. Following efforts to mitigate disease spread, with a significant decline in some regions, many states began reopening their economies. As social distancing guidelines were relaxed and businesses opened, local outbreaks of COVID-19 continue to place person on healthcare systems. Among medical specialties, otolaryngologists and their staff are among the highest at risk for becoming exposed to COVID-19. As otolaryngologists prepare to weather the storm of impending local surges in COVID-19 infections there are several practical measures that can be taken to mitigate the risk to ourselves and our staff. url: https://doi.org/10.1016/j.amjoto.2020.102688 doi: 10.1016/j.amjoto.2020.102688 id: cord-279732-cea0nt8z author: Bentley, Suzanne K. title: Guidance and Patient Instructions for Proning and Repositioning of Awake, Non‐Intubated COVID‐19 Patients date: 2020-06-29 words: 963.0 sentences: 62.0 pages: flesch: 43.0 cache: ./cache/cord-279732-cea0nt8z.txt txt: ./txt/cord-279732-cea0nt8z.txt summary: Literature and experience from healthcare teams in the midst of the pandemic suggest that any COVID‐19 patients with respiratory compromise severe enough to warrant admission should be considered for proning. Prior studies on proning awake, non-intubated patients with hypoxemic acute respiratory failure, 1,2 as well as evolving study of similar COVID-19 patients, [3] [4] [5] [6] coupled with experience and dramatic anecdotal evidence from the COVID-19 pandemic, suggest the importance of proning all such patients with COVID-19 to improve oxygenation and reduce respiratory effort. Literature and experience from healthcare teams in the midst of the pandemic suggest that any COVID-19 patients with respiratory compromise severe enough to warrant admission should be considered for proning. All rights reserved Care Society Guidance for Prone Positioning of the Conscious COVID-19 Patient 7 includes the following absolute contraindications: acute respiratory distress (requiring higher level intervention e.g. immediate need for intubation), hemodynamic instability, agitation or altered mental status, unstable spine, thoracic injury, or recent abdominal surgery. abstract: Prior studies on proning awake, non‐intubated patients with hypoxemic acute respiratory failure, as well as evolving study of similar COVID‐19 patients, coupled with experience and dramatic anecdotal evidence from the COVID‐19 pandemic, suggest the importance of proning all such patients with COVID‐19 to improve oxygenation and reduce respiratory effort. Literature and experience from healthcare teams in the midst of the pandemic suggest that any COVID‐19 patients with respiratory compromise severe enough to warrant admission should be considered for proning. We additionally suggest these patients should be considered for proning as well as ongoing patient re‐positioning (e.g. right lateral decubitus, seated, and left lateral decubitus positions). Figure 1 represents the proning and positioning instructions developed at New York City Health + Hospitals/Elmhurst, a large, inner‐city, tertiary public hospital in the epicenter of the COVID‐19 pandemic in New York City, and later adapted and utilized at facilities across the United States. url: https://www.ncbi.nlm.nih.gov/pubmed/32597005/ doi: 10.1111/acem.14067 id: cord-316728-vyfkmniu author: Benyounes, Nadia title: Echocardiography in Confirmed and Highly Suspected Symptomatic COVID-19 Patients and Its Impact on Treatment Change date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: COVID-19 interacts at multiple levels with the cardiovascular system. The prognosis of COVID-19 infection is known to be worse for patients with underlying cardiovascular diseases. Furthermore, the virus is responsible for many cardiovascular complications. Myocardial injury may affect up to 20% of the critically ill patients. However, echocardiography's impact on the management of patients affected by COVID-19 remains unknown. OBJECTIVES: To explore echocardiography's impact on the management of COVID-19 patients. METHODS: This study was conducted from March 24(th) to April 14(th), 2020, in a single center at Adolphe de Rothschild Foundation Hospital, Paris, France. All consecutive inpatients with laboratory and/or CT COVID-19 diagnosis were included in this study. Patients' characteristics (clinical, biological, and imaging) and treatment change induced by echocardiography were collected and analyzed. Patients with and without treatment change induced by echocardiography were compared. RESULTS: A total of 56 echocardiographies in 42 patients with highly suspected or confirmed COVID-19 were included in the final analyses. The median age was 66 (IQR 60.5–74). Echocardiography induced a treatment change in 9 cases (16%). The analyzed clinical data were not associated with any treatment change induced by echocardiography. D-dimer and Troponin levels were the only biological predictors of the induced treatment change. On echocardiography, higher systolic pulmonary arterial pressure and documented cardiac thrombi were associated with treatment changes in these patients. CONCLUSIONS: Echocardiography may be useful for the management of selected COVID-19 patients, especially those with elevated D-Dimer and Troponin levels, in up to 16% of patients. url: https://doi.org/10.1155/2020/4348598 doi: 10.1155/2020/4348598 id: cord-286611-e1i1wemo author: Benziger, Catherine P. title: The Telehealth Ten: A Guide for a Patient-Assisted Virtual Physical Exam date: 2020-07-18 words: 1781.0 sentences: 114.0 pages: flesch: 62.0 cache: ./cache/cord-286611-e1i1wemo.txt txt: ./txt/cord-286611-e1i1wemo.txt summary: We propose the "Telehealth Ten", which is a patient-assisted clinical examination to help guide clinicians through this new territory. Observing the patient''s gait and level of effort to walk into the room and to sit up on the exam table can be useful to assess his or her functional performance. This evaluation can be enhanced using digital devices, such as wearables for heart rate and electrocardiogram (ECG) and home monitoring devices (scale, blood pressure cuff, and pulse oximeter), which are potentially available to patients. We propose the "Telehealth Ten", which is a patient-assisted clinical examination to help guide clinicians through this new territory (Table 1) . We recommend that patients use a validated, digital, upper arm blood pressure (BP) cuff to measure their BP and heart rate and an electronic scale for measuring daily body weight. Ask patients to look at their face, neck, arms including elbows, chest, abdomen, and legs. abstract: Given the COVID-19 pandemic and the need to keep vulnerable people at home to decrease risk of virus transmission, there has been a rapid rise in use of virtual, or telehealth, visits. A new reliance on telehealth requires many clinicians to develop skills to obtain objective information from these types of visits. We propose the “Telehealth Ten”, which is a patient-assisted clinical examination to help guide clinicians through this new territory. Adapting to this new reality takes time and requires future investigation. url: https://www.ncbi.nlm.nih.gov/pubmed/32687813/ doi: 10.1016/j.amjmed.2020.06.015 id: cord-292474-dmgd99d6 author: Berardi, Giammauro title: Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center date: 2020-06-04 words: 4605.0 sentences: 222.0 pages: flesch: 43.0 cache: ./cache/cord-292474-dmgd99d6.txt txt: ./txt/cord-292474-dmgd99d6.txt summary: As the Italian National Institute for the Infectious Diseases, we have hospitalized the first Italian COVID-19 patients and since then, our general surgery department had to face this reality [16] . Pancreatic resections, total gastrectomies, major hepatectomies, and multivisceral resections as well as liver and kidney transplantations were considered as the high-risk surgical procedures because of the increased likelihood of postoperative ICU admission. On January 31, 2020 (Day 0), the first two COVID-19-positive patients in Italy were admitted to the department of infectious diseases of our hospital with mild fever and atypical pneumonia requiring no invasive treatment. Considering only the transplantations and the operations performed for cancer, patients in the second period had fewer comorbidities, lower ASA score, CCI, and RCRI, being overall at lower risk of postoperative ICU admission (Table 3) . As an institutional policy, our transplant center remained opened and we decided to continue with our standard surgical oncology activity, improving selection of patients to limit the need for postoperative intensive care management. abstract: COVID-19 is rapidly spreading worldwide. Healthcare systems are struggling to properly allocate resources while ensuring cure for diseases outside of the infection. The aim of this study was to demonstrate how surgical activity was affected by the virus outbreak and show the changes in practice in a tertiary referral COVID-19 center. The official bulletins of the Italian National Institute for the Infectious Diseases “L. Spallanzani” were reviewed to retrieve the number of daily COVID-19 patients. Records of consecutive oncological and transplant procedures performed during the outbreak were reviewed. Patients with a high probability of postoperative intensive care unit (ICU) admission were considered as high risk and defined by an ASA score ≥ III and/or a Charlson Comorbidity Index (CCI) ≥ 6 and/or a Revised Cardiac Risk Index for Preoperative Risk (RCRI) ≥ 3. 72 patients were operated, including 12 (16.6%) liver and kidney transplantations. Patients had few comorbidities (26.3%), low ASA score (1.9 ± 0.5), CCI (3.7 ± 1.3), and RCRI (1.2 ± 0.6) and had overall a low risk of postoperative ICU admission. Few patients had liver cirrhosis (12.5%) or received preoperative systemic therapy (16.6%). 36 (50%) high-risk surgical procedures were performed, including major hepatectomies, pancreaticoduodenectomies, total gastrectomies, multivisceral resections, and transplantations. Despite this, only 15 patients (20.8%) were admitted to the ICU. Only oncologic cases and transplantations were performed during the COVID-19 outbreak. Careful selection of patients allowed to perform major cancer surgeries and transplantations without further stressing hospital resources, meanwhile minimizing collateral damage to patients. url: https://doi.org/10.1007/s13304-020-00825-3 doi: 10.1007/s13304-020-00825-3 id: cord-347263-ci6mv72z author: Berekashvili, k. title: Etiologic Subtypes of Ischemic Stroke in SARS-COV-2 Virus patients date: 2020-05-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective: To describe the ischemic stroke etiopathogenesis related to COVID-19 in a cohort of NYC hospitals. Background: Extra-pulmonary involvement of COVID-19 has been reported in the hepatic, renal and hematological systems. Most neurological manifestations are non-focal but few have reported the characteristics of ischemic strokes or investigated its pathophysiology. Methods: Over the last 6 weeks, data from four centers in New York City were collected to review the possible ischemic stroke types seen in COVID-19 positive patients. Their presentation, demographics, other related vascular risk factors, associated laboratory and coagulation markers, as well as imaging and outcomes were collected. Results: In our study, age range of patients was 25-75 with no significant male preponderance. 70% presented for acute hospitalization due the stroke. About a fifth did not have common risk factors for ischemic stroke like diabetes and hypertension. None had history of atrial fibrillation or smoking. 50% had poor outcome with four ending in mortality and one in a critical condition due ARDS. All had high Neutrophil/Lymphocyte ratio except one who demonstrated some neurological recovery. In 70% of our cases, D-dimer levels were collected, and all showed mild to severe elevation. None of the emergent large vessel occlusion (LVO) cases had known cardiac risk factors but two out of five were found to have cardiac abnormalities during the course of their hospitalization. All LVOs had hypercoagulable lab markers especially elevated D-dimer and/or Fibrinogen. The LVO patients were younger and sicker with a median age of 46 and mean NIHSS of 24 as opposed to non-LVOs with a median age of 62 and mean NIHSS of 6 respectively. Conclusion: COVID-19 related ischemic events can be small vessel, branch emboli or large vessel occlusions. The latter is often associated with either a hypercoagulable state or cardio-embolism. Patient outcomes were worse when multi-organ or pulmonary system failure prevailed. Keywords: COVID-19, Acute Ischemic strokes, Emergent Large Vessel Occlusion, Mechanical Thrombectomy url: http://medrxiv.org/cgi/content/short/2020.05.03.20077206v1?rss=1 doi: 10.1101/2020.05.03.20077206 id: cord-016960-xhzvp35g author: Berencsi, György title: Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy date: 2012-03-08 words: 17693.0 sentences: 1045.0 pages: flesch: 42.0 cache: ./cache/cord-016960-xhzvp35g.txt txt: ./txt/cord-016960-xhzvp35g.txt summary: The importance of maternal anti-idiotypic antibodies are believed to prime the fetal immune system with epitopes of etiologic agents infected the mother during her whole life before pregnancy and delivery. Neonatal lupus is a model of passively acquired autoimmunity in which a mother-, who may have systemic lupus erythematosus (SLE) or Sj€ ogren''s syndrome (SS) or may be entirely asymptomatic-synthesizes antibodies to SSA/Ro and/or SSB/ La ribonucleoproteins that enter the fetal circulation via trophoblast FcRn receptors and presumably cause tissue injury (Lee 1990 ) as mentioned above. Teplizumab (CD3-specific, hOKT3g1-Ala-Ala), a humanized Fc mutated anti-CD3 monoclonal antibody induced tolerance, on the progression of type 1 diabetes in patients with recent-onset disease even 2 years after the first diagnosis (Herold et al. Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells abstract: The human fetus is protected by the mother’s antibodies. At the end of the pregnancy, the concentration of maternal antibodies is higher in the cord blood, than in the maternal circulation. Simultaneously, the immune system of the fetus begins to work and from the second trimester, fetal IgM is produced by the fetal immune system specific to microorganisms and antigens passing the maternal-fetal barrier. The same time the fetal immune system has to cope and develop tolerance and T(REG) cells to the maternal microchimeric cells, latent virus-carrier maternal cells and microorganisms transported through the maternal-fetal barrier. The maternal phenotypic inheritance may hide risks for the newborn, too. Antibody mediated enhancement results in dengue shock syndrome in the first 8 month of age of the baby. A series of pathologic maternal antibodies may elicit neonatal illnesses upon birth usually recovering during the first months of the life of the offspring. Certain antibodies, however, may impair the fetal or neonatal tissues or organs resulting prolonged recovery or initiating prolonged pathological processes of the children. The importance of maternal anti-idiotypic antibodies are believed to prime the fetal immune system with epitopes of etiologic agents infected the mother during her whole life before pregnancy and delivery. The chemotherapeutical and biological substances used for the therapy of the mother will be transcytosed into the fetal body during the last two trimesters of pregnancy. The long series of the therapeutic monoclonal antibodies and conjugates has not been tested systematically yet. The available data are summarised in this chapter. The innate immunity plays an important role in fetal defence. The concentration of interferon is relative high in the placenta. This is probably one reason, why the therapeutic interferon treatment of the mother does not impair the fetal development. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121401/ doi: 10.1007/978-94-007-4216-1_9 id: cord-334835-j6u8t8j2 author: Berenguer, Juan title: Characteristics and predictors of death among 4,035 consecutively hospitalized patients with COVID-19 in Spain date: 2020-08-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: We aimed to analyse the characteristics and predictors of death in hospitalized patients with COVID-19 in Spain. METHODS: Retrospective observational study of the first consecutive patients hospitalized with COVID-19 confirmed by real-time polymerase chain reaction (RT-PCR) assay in 127 Spanish centres until March 17, 2020. The follow-up censoring date was April 17, 2020. We collected demographic, clinical, laboratory, treatment, and complications data. The primary endpoint was all-cause mortality. Univariable and multivariable Cox regression analyses were performed to identify factors associated with death. RESULTS: Of the 4,035 patients, males accounted for 2,433/3,987 (61.0%), the median age was 70 years, and 2,539/3,439 (73.8%) had >1 comorbidity. The most common symptoms were a history of fever, cough, malaise, and dyspnoea. During hospitalization 1,255/3,979 (31.5%) patients developed acute respiratory distress syndrome, 736/3,988 (18.5%) were admitted to intensive care units, and 619/3,992 (15.5%) underwent mechanical ventilation. Viral or host-targeted medications included lopinavir/ritonavir 2,820/4,005 (70.4%), hydroxychloroquine 2,618/3,995 (65.5%), interferon-beta 1,153/3,950 (29.2%), corticosteroids 1,109/3,965 (28.0%), and tocilizumab 373/3,951 (9.4%). Overall 1,131/4,035 (28%) patients died. Mortality increased with age (85.6% occurring in older than 65 years). Seventeen factors were independently associated with an increased hazard of death, the strongest among them included advanced age, liver cirrhosis, low age-adjusted oxygen saturation, higher concentrations of C-reactive protein, and lower estimated glomerular filtration rate. CONCLUSIONS: Our findings provide comprehensive information about characteristics and complications of severe COVID-19 and may help to identify patients at a higher risk of death. url: https://doi.org/10.1016/j.cmi.2020.07.024 doi: 10.1016/j.cmi.2020.07.024 id: cord-335312-yp73z008 author: Bergsland, Emily K. title: North American Neuroendocrine Tumor Society Guide for Neuroendocrine Tumor Patient Health Care Providers During COVID-19 date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1097/mpa.0000000000001561 doi: 10.1097/mpa.0000000000001561 id: cord-331114-lumfg138 author: Berkman, Samuel A title: Methodological Issues and Controversies in COVID-19 Coagulopathy: A Tale of Two Storms date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Venous thromboembolism, occlusion of dialysis catheters, circuit thrombosis in ECMO devices, all in the face of prophylactic and sometimes even therapeutic anti-coagulation, are frequent features of COVID-19 coagulopathy. The trials available to guide clinicians are methodologically limited. There are several unresolved controversies including 1) Should all hospitalized patients with COVID-19 receive prophylactic anti-coagulation? 2) Which patients should have their dosage escalated to intermediate dose? 3) Which patients should be considered for full-dose anti-coagulation even without a measurable thromboembolic event and how should that anti-coagulation be monitored? 4) Should patients receive post-discharge anti-coagulation? 5) What thrombotic issues are related to the various medications being used to treat this coagulopathy? 6) Is anti-phospholipid anti-body part of this syndrome? 7) How do the different treatments for this disease impact the coagulation issues? The aims of this article are to explore these questions and interpret the available data based on the current evidence. url: https://doi.org/10.1177/1076029620945398 doi: 10.1177/1076029620945398 id: cord-275154-vwnpred5 author: Bermejo-Martin, Jesus F title: Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza date: 2009-12-11 words: 4648.0 sentences: 260.0 pages: flesch: 48.0 cache: ./cache/cord-275154-vwnpred5.txt txt: ./txt/cord-275154-vwnpred5.txt summary: Conclusions While infection with the nvH1N1 induces a typical innate response in both mild and severe patients, severe disease with respiratory involvement is characterized by early secretion of Th17 and Th1 cytokines usually associated with cell mediated immunity but also commonly linked to the pathogenesis of autoimmune/inflammatory diseases. Conclusions While infection with the nvH1N1 induces a typical innate response in both mild and severe patients, severe disease with respiratory involvement is characterized by early secretion of Th17 and Th1 cytokines usually associated with cell mediated immunity but also commonly linked to the pathogenesis of autoimmune/inflammatory diseases. To determine if host immune responses play a potential role in the evolution of mild or severe nvH1N1 illness we performed an analysis of systemic chemokine and cytokine levels in serum from severe and mild nvH1N1 patients shortly following the onset of symptoms. abstract: INTRODUCTION: Human host immune response following infection with the new variant of A/H1N1 pandemic influenza virus (nvH1N1) is poorly understood. We utilize here systemic cytokine and antibody levels in evaluating differences in early immune response in both mild and severe patients infected with nvH1N1. METHODS: We profiled 29 cytokines and chemokines and evaluated the haemagglutination inhibition activity as quantitative and qualitative measurements of host immune responses in serum obtained during the first five days after symptoms onset, in two cohorts of nvH1N1 infected patients. Severe patients required hospitalization (n = 20), due to respiratory insufficiency (10 of them were admitted to the intensive care unit), while mild patients had exclusively flu-like symptoms (n = 15). A group of healthy donors was included as control (n = 15). Differences in levels of mediators between groups were assessed by using the non parametric U-Mann Whitney test. Association between variables was determined by calculating the Spearman correlation coefficient. Viral load was performed in serum by using real-time PCR targeting the neuraminidase gene. RESULTS: Increased levels of innate-immunity mediators (IP-10, MCP-1, MIP-1β), and the absence of anti-nvH1N1 antibodies, characterized the early response to nvH1N1 infection in both hospitalized and mild patients. High systemic levels of type-II interferon (IFN-γ) and also of a group of mediators involved in the development of T-helper 17 (IL-8, IL-9, IL-17, IL-6) and T-helper 1 (TNF-α, IL-15, IL-12p70) responses were exclusively found in hospitalized patients. IL-15, IL-12p70, IL-6 constituted a hallmark of critical illness in our study. A significant inverse association was found between IL-6, IL-8 and PaO2 in critical patients. CONCLUSIONS: While infection with the nvH1N1 induces a typical innate response in both mild and severe patients, severe disease with respiratory involvement is characterized by early secretion of Th17 and Th1 cytokines usually associated with cell mediated immunity but also commonly linked to the pathogenesis of autoimmune/inflammatory diseases. The exact role of Th1 and Th17 mediators in the evolution of nvH1N1 mild and severe disease merits further investigation as to the detrimental or beneficial role these cytokines play in severe illness. url: https://www.ncbi.nlm.nih.gov/pubmed/20003352/ doi: 10.1186/cc8208 id: cord-261240-osbk041e author: Bermejo-Martin, Jesús F title: Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection date: 2020-03-05 words: 969.0 sentences: 55.0 pages: flesch: 44.0 cache: ./cache/cord-261240-osbk041e.txt txt: ./txt/cord-261240-osbk041e.txt summary: The presence of lymphopenia as a signature of severe COVID-19 was confirmed by Wang D et al., who, in their study published in JAMA, reported that ICU patients suffering this infection had a median lymphocyte count of 800 cells/mm [3] , with non survivors exhibiting persistent lymphopenia [4] . Interestingly, hypercytokinemia and lymphopenia were also evident in critical patients with Severe Acute Respiratory Syndrome due to the Coronavirus emerged in 2003 (SARS-CoV) [5 , 6] . These features (lymphopenia + hypercytokinemia) fit the characteristics of a particular immunological phenotype of community acquired pneumonia (CAP), lymphopenic CAP (L-CAP), which, as we recently demonstrated in an article published in the Journal of Infection, is associated with increased severity, mortality and a dysregulated immunological response [7] . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0163445320301109 doi: 10.1016/j.jinf.2020.02.029 id: cord-010658-67k8pthy author: Bernard, Andie title: PC-FACS May 2020 for July 2020 Issue date: 2020-05-07 words: 1923.0 sentences: 123.0 pages: flesch: 45.0 cache: ./cache/cord-010658-67k8pthy.txt txt: ./txt/cord-010658-67k8pthy.txt summary: To expertly guide patients through this often devastating illness, palliative care professionals will need to keep abreast of the COVID-19 literature as the pandemic evolves and the longer-term outcomes come into sharper focus. Bottom Line: Early reports of COVID-19-associated pneumonia and ARDS provide insights into risk factors, short-term prognosis, and mortality that are important for palliative care professionals to be aware of when counselling patients and families. This article discussed a component of an appropriate response to the COVID-19 pandemic: ensuring that clinicians have discussions about advance care planning (especially with older patients with chronic illness) and goals of care with patients/families. This pandemic heightens the importance of implementing do-not-resuscitate (DNR) orders for appropriate patients: although unwanted/nonbeneficial CPR always risks increasing psychological distress for patients'' families, inappropriate CPR now is especially stressful and potentially dangerous for healthcare workers. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204659/ doi: 10.1016/j.jpainsymman.2020.05.001 id: cord-323024-blc3mnbj author: Bernard-Valnet, R. title: CSF of SARS-CoV-2 patients with neurological syndromes reveals hints to understand pathophysiology date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective: Coronavirus disease (COVID-19) has been associated with a large variety of neurological disorders. However the mechanisms underlying these neurological complications remain elusive. In this study we aimed at determining whether neurological symptoms were caused by SARS-CoV-2 direct infection of by pro-inflammatory mediators. Methods: We checked for SARS-CoV-2 RNA by RT-qPCR, SARS-CoV-2-specific antibodies and for 48 cytokines/chemokines/growth factors (by Luminex) in the cerebrospinal fluids (CSF) +/- sera of a cohort of 17 COVID-19 patients with neurological presentation and 55 neurological control patients (inflammatory [IND], non inflammatory [NIND], multiple sclerosis [MS]). Results: We found SARS-CoV-2 RNA and antibodies specific for this virus in the CSF of 0/17 and 8/16 COVID-19 patients, respectively. The presence of SARS-CoV-2 antibodies was explained by a rupture of the blood brain barrier (passive transfer) in 6/16 (38%). An intrathecal synthesis of SARS-CoV2-specific antibodies was present in 2/16 patients. Of the four categories of tested patients, the CSF of IND exhibited the highest level of chemokines (CCL4, CCL5, CXCL8, CXCL10, CXCL12, and CXCL13), followed by the CSF of MS patients (CXCL12, and CXCL13). There was no significant difference between COVID-19 and NIND patients, even if some chemokines (CCL4, CCL5, CXCL8, andCXCL10) tended to be higher in the former. Interestingly, among COVD-19 patients, the CSF of those with a severe disease (encephalitis/encephalopathy) contained higher levels CXCL8 and CXCL10 than those with other neurological presentations. Interpretation: Our results do not show obvious SARS-CoV-2 infection of the central nervous system, but point to a mild inflammatory reaction reflecting an astrocytic reaction. Methods: We checked for SARS-CoV-2 mRNA by qPCR, SARS-CoV-2-specific antibodies and for 49 cytokines/chemokines/growth factors (by Luminex) in the cerebrospinal fluid (CSF) +/- serum of a cohort of 17 COVID-19 patients with neurological presentation and 55 neurological controls (inflammatory, non inflammatory, multiple sclerosis). Results: We found SARS-CoV-2 mRNA and antibodies specific for this virus in the CSF of 0/17 and 8/16 COVID-19 patients, respectively. The presence of SARS-CoV-2 antibodies was explained by a rupture of the blood brain barrier (passive transfer) in 6/16 (37,5%), but an intrathecal synthesis of SARS-CoV2-specific antibodies was present in 2/17.As compared to SARS-CoV-2-negative NIND patients, the CSF of IND patients exhibited the highest level of chemokines (CCL4, CCL5, CXCL8, CXCL10, CXCL12, and CXCL13), followed the CSF of MS patients (CXCL12, and CXCL13). There was no difference between COVID-19 patients with neurological diseases compared to NIND even if some chemokines (CCL4, CCL5, CXCL8, andCXCL10) tended to be higher than NIND. Interestingly, among COVD-19 patients, the CSF of those with a severe disease (encephalitis/encephalopathy) contained higher levels CXCL8 and CXCL10 than those with other neurological presentations. Interpretation: Our results confirm the absence of obvious SARS-CoV-2 infection of the central nervous system and point to a mild inflammatory reaction reflecting an astrocytic reaction. url: http://medrxiv.org/cgi/content/short/2020.11.01.20217497v1?rss=1 doi: 10.1101/2020.11.01.20217497 id: cord-309024-pu830bn9 author: Bernardo, Luca title: Severe prolonged neutropenia following administration of tocilizumab in a patient affected by COVID-19: a case report and brief review of the literature date: 2020-09-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Tocilizumab is one of the newest therapeutic options for the acute respiratory distress syndrome (ARDS) caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) β-coronavirus. Several trials are currently ongoing to assess the efficacy and safety profile of tocilizumab in treating ARDS. In this article, we present the case of a Black patient with acute pneumonia who benefited greatly from tocilizumab, but developed severe prolonged neutropenia. Considering the increasing use of tocilizumab among patients with coronavirus disease 2019 (COVID-19), this case warrants further research regarding the possible adverse hematological effects that need to be monitored in order to prevent secondary infections. url: https://doi.org/10.1007/s40267-020-00777-z doi: 10.1007/s40267-020-00777-z id: cord-299449-226dd23u author: Bernhardt, Denise title: Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas date: 2020-05-05 words: 4200.0 sentences: 221.0 pages: flesch: 45.0 cache: ./cache/cord-299449-226dd23u.txt txt: ./txt/cord-299449-226dd23u.txt summary: It is acknowledged that the SARS-CoV-2 pandemic will require center specific discussions of appropriate resource allocation that considers patient and provider safety, resource constraints, and a realistic evaluation of the impact of therapy upon Incurable brain tumors. This international multidisciplinary group of experts in HGG provides a risk-adapted framework for decisions in both pandemic scenarios, considering both ethical issues and resource constraints, in order to minimize the irreparable damage associated with withholding necessary treatments. We recognize that during the pandemic the challenges of ICU capacity, conservation of PPE, availability of health care professional expertise and the risk for patients'' exposure to SARS-CoV-2 may reduce the ability to provide optimal surgical management. Patients and caregivers should be included in the decision-making process as much as possible, and this should include all relevant data on chemotherapy and radiotherapy, as well as the individual risk profile associated with a potential SARS-CoV-2 infection. abstract: BACKGROUND: Because of the increased risk in cancer patients of developing complications caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), physicians have to balance the competing risks of the negative impact of the pandemic and the primary tumor. In this consensus statement, an international group of experts present mitigation strategies and treatment guidance for patients suffering from high grade gliomas (HGG) during the coronavirus disease 2019 (COVID-19) pandemic. METHOD / RESULTS: 16 international experts in the treatment of HGG contributed to this consensus-based practice recommendation including neuro-oncologists, neurosurgeons, radiation -oncologists and a medical physicist. Generally, treatment of neuro-oncological patients cannot be significantly delayed and initiating therapy should not be outweighed by COVID-19. We present detailed interdisciplinary treatment strategies for molecular subgroups in two pandemic scenarios, a scale-up phase and a crisis phase. CONCLUSION: This practice recommendation presents a pragmatic framework and consensus-based mitigation strategies for the treatment of HGG patients during the SARS-CoV-2 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32369601/ doi: 10.1093/neuonc/noaa113 id: cord-312209-3yi1w44v author: Bernstein, David N title: Transforming the Orthopaedic Patient Experience Through Telemedicine date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1177/2374373520929449 doi: 10.1177/2374373520929449 id: cord-009575-bd67ph64 author: Berr, C. title: Risk factors in multiple sclerosis: a population‐based case‐control study in Hautes‐Pyrénées, France date: 2009-01-29 words: 1965.0 sentences: 118.0 pages: flesch: 57.0 cache: ./cache/cord-009575-bd67ph64.txt txt: ./txt/cord-009575-bd67ph64.txt summary: ABSTRACT‐ A population‐based study of the prevalence and risk factors of multiple sclerosis (MS) was conducted in the Hautes‐Pyrénées, the southwestern region of France. The mumps antibody titer was significantly higher in the MS patients than in the controls. Patients and controls were asked whether they had ever contracted the following infectious diseases: rubella, measles, varicella, mumps, viral hepatitis, herpes simplex, zoster, pertussis, chronic sinusitis, and upper airways infections ( Table 2) . Age at the time of immunization was significantly higher for patients than controls (15.8 years versus 8.9 years, A history of familial MS was reported by 4 There was no association between antibody levels and clinical features, including sex, age at onset of MS, and the course of the disease. Nevertheless, MS patients tended to have higher measles antibody titers than controls. Risk factors in multiple sclerosis: tuberculin reactivity, age at measles infection, tonsillectomy and appendicectomy Viral infection in patients with multiple sclerosis and HLA-DR matched controls abstract: ABSTRACT‐ A population‐based study of the prevalence and risk factors of multiple sclerosis (MS) was conducted in the Hautes‐Pyrénées, the southwestern region of France. The prevalence rate per 100,000 was equal to 40. Data on the past medical history of 63 MS patients and matched controls were collected. The frequency and age at occurrence of common childhood infections were similar for both the MS cases and controls. There was no difference between the frequency of vaccination for MS patients and for controls. However, the age at which MS patients were immunized against poliomyelitis was significantly higher than the corresponding age for controls (15.8 years versus 8.9 years, P < 0.01). Antibody titers for various viruses were measured. The mumps antibody titer was significantly higher in the MS patients than in the controls. Also, MS patients tended to have higher titers for measles antibodies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159688/ doi: 10.1111/j.1600-0404.1989.tb03841.x id: cord-289457-06gwrpu0 author: Berth, Sarah H. title: Secondary Causes of Myositis date: 2020-10-06 words: 3811.0 sentences: 233.0 pages: flesch: 29.0 cache: ./cache/cord-289457-06gwrpu0.txt txt: ./txt/cord-289457-06gwrpu0.txt summary: The term "myositis" is often used interchangeably with "idiopathic inflammatory myopathy" (IIM), referring to primary autoimmune diseases of muscle including dermatomyositis, inclusion body myositis (IBM), antisynthetase syndrome, and necrotizing autoimmune myopathy [1] [2] [3] [4] [5] [6] . Another case series of three patients with dermatomyositis-associated cGVHD showed improvement with immunosuppression via combination treatment of corticosteroids, tacrolimus, rituximab, mycophenolate mofetil, and/or IVIG [43] . Patients with polymyositis or dermatomyositis that underwent intensive aerobic exercise combined with resistance training in a randomized controlled trial have improved muscle function, quality of life, and possible reduced disease activity [89] . A pilot study of 20 patients with refractory dermatomyositis or polymyositis using abatacept found that almost half of their patients showed reduced disease activity and improved muscle performance after treatment for 6 months [98] , and there is now a phase III, randomized, double-blind trial to further evaluate abatacept for myositis treatment (ClinicalTrials.gov identifier: NCT02971683). abstract: PURPOSE OF REVIEW: The purpose of this paper is to comprehensively evaluate secondary causes of inflammatory myopathies (myositis) and to review treatment options. RECENT FINDINGS: This review highlights recent advancements in our understanding of known causes of myositis, including newer drugs that may cause myositis such as checkpoint inhibitors and viruses such as influenza, HIV, and SARS-CoV2. We also discuss treatment for malignancy-associated myositis and overlap myositis, thought to be a separate entity from other rheumatologic diseases. SUMMARY: Infections, drugs, rheumatologic diseases, and malignancies are important causes of myositis and are important to diagnose as they may have specific therapies beyond immunomodulatory therapy. url: https://www.ncbi.nlm.nih.gov/pubmed/33041620/ doi: 10.1007/s11940-020-00646-0 id: cord-280280-9jr7ekbu author: Bertoncelli, Deborah title: COVID19: potential cardiovascular issues in pediatric patients date: 2020-05-11 words: 3393.0 sentences: 181.0 pages: flesch: 36.0 cache: ./cache/cord-280280-9jr7ekbu.txt txt: ./txt/cord-280280-9jr7ekbu.txt summary: Ongoing studies and accumulated data are detailing the features and the effects of the new coronavirus disease 19 (COVID 19) in the adult population, and cardiovascular involvement is emerging as the most significant and life-threatening complication, with an increased risk of morbidity and mortality in patients with underlying cardiovascular disease. At present, though the limited data on the effects of COVID 19 in pediatric patients, children seem to count for a little proportion of SARS-COV 2 infection, and present with less severe disease and effects However infants and toddlers are at risk of developing critical course. Coronavirus disease 19 (COVID-19) is a severe acute respiratory syndrome for which the etiologic agent is the novel beta coronavirus SARS-CoV-2, first described in December 2019 in China in a cluster of patients presenting with pneumonia. The main presenting clinical feature of the disease is pneumonia, ranging from asymptomatic or mildly symptomatic to severe acute respiratory distress syndrome, but cardiovascular involvement is emerging as one of the most significant and life-threatening complications of SARS-CoV-2 infection (1, 2) . abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) has rapidly spread worldwide with increasing hospitalization and mortality rate. Ongoing studies and accumulated data are detailing the features and the effects of the new coronavirus disease 19 (COVID 19) in the adult population, and cardiovascular involvement is emerging as the most significant and life-threatening complication, with an increased risk of morbidity and mortality in patients with underlying cardiovascular disease. At present, though the limited data on the effects of COVID 19 in pediatric patients, children seem to count for a little proportion of SARS-COV 2 infection, and present with less severe disease and effects However infants and toddlers are at risk of developing critical course. The disease has a range of clinical presentations in children, for which the potential need for further investigation of myocardial injury and cardiovascular issues should be kept in mind to avoid misdiagnosing severe clinical entities. Overlapping with Kawasaki disease is a concern, particularly the incomplete and atypical form. We aim to summarize the initial considerations and potential cardiovascular implications of COVID-19 for children and patients with congenital heart disease. (www.actabiomedica.it) url: https://doi.org/10.23750/abm.v91i2.9655 doi: 10.23750/abm.v91i2.9655 id: cord-298967-vjyh1xvh author: Bertossi, Dario title: Safety guidelines for non‐surgical facial procedures during covid‐19 outbreak date: 2020-06-07 words: 2005.0 sentences: 130.0 pages: flesch: 51.0 cache: ./cache/cord-298967-vjyh1xvh.txt txt: ./txt/cord-298967-vjyh1xvh.txt summary: METHODS: A virtual meeting was conducted with the members (n=12) of the European Academy of Facial Plastic Surgery Focus Group to outline the safety protocol for the non‐surgical facial aesthetic procedures for aesthetic practices in order to protect the clinic staff and the patients from SARS‐CoV‐2 infection. While many medical Accepted Article practices are being run with online consultations 10 , some countries have recently decided to allow the opening of practices requiring one-on-one contact like dental, physiotherapy, for emergencies provided they strictly follow the guidelines detailing the infection control measures [12] [13] . In our largely elective field, both staff and resources should ideally be allocated through careful protocols in order to prevent COVID-19 infection. In response to this pandemic, our focus group has developed a process to stratify procedures and clinical levels with protocols that aim to minimize the risk of contagion and the diffusion of COVID-19 infection. abstract: BACKGROUND: The novel coronavirus (COVID‐19) pandemic is expected to last for an extended time, making strict safety precautions for office procedures unavoidable. The lockdown is going to be lifted in many areas, and strict guidelines detailing the infection control measures for aesthetic clinics are going to be of particular importance. METHODS: A virtual meeting was conducted with the members (n=12) of the European Academy of Facial Plastic Surgery Focus Group to outline the safety protocol for the non‐surgical facial aesthetic procedures for aesthetic practices in order to protect the clinic staff and the patients from SARS‐CoV‐2 infection. The data analysis was undertaken by thematic and iterative approach. RESULTS: Consensus guidelines for non‐surgical facial aesthetic procedures based on current knowledge are provided for three levels: precautions before visiting the clinic, precautions during the clinic visit, and precautions after the clinic visit. CONCLUSIONS: Sound infection control measures are mandatory for non‐surgical aesthetic practices all around the world. These may vary from country to country, but this logical approach can be customized according to the respective country laws and guidelines. url: https://www.ncbi.nlm.nih.gov/pubmed/32506541/ doi: 10.1111/jocd.13530 id: cord-272727-a5ngjuyz author: Bertsimas, D. title: From predictions to prescriptions: A data-drivenresponse to COVID-19 date: 2020-06-29 words: 3596.0 sentences: 209.0 pages: flesch: 53.0 cache: ./cache/cord-272727-a5ngjuyz.txt txt: ./txt/cord-272727-a5ngjuyz.txt summary: Specifically, we propose a comprehensive data-driven approach to understand the clinical characteristics of COVID-19, predict its mortality, forecast its evolution, and ultimately alleviate its impact. Each column reports 128 cohort-level statistics on demographics (e.g., average age, gen-129 der breakdown), comorbidities (e.g., prevalence of diabetes, 130 hypertension), symptoms (e.g., prevalence of fever, cough), 131 treatments (e.g., prevalence of antibiotics, intubation), lab 132 values (e.g., average lymphocyte count), and clinical outcomes 133 (e.g., average hospital length of stay, mortality rate). The models with lab values provide 309 algorithmic screening tools that can deliver COVID-19 risk 310 predictions using common clinical features. These findings 333 are also in agreement with clinical reports: an elevated CRP 334 generally indicates an early sign of infection and implies lung 335 lesions from COVID-19 (27), elevated levels of leukocytes 336 suggest cytokine release syndrome caused by SARS-CoV-2 337 virus (28), and lowered levels of serum calcium signal higher 338 rate of organ injury and septic shock (29) . abstract: The COVID-19 pandemic has created unprecedented challenges worldwide. Strained healthcare providers make difficult decisions on patient triage, treatment and care management on a daily basis. Policy makers have imposed social distancing measures to slow the disease, at a steep economic price. We design analytical tools to support these decisions and combat the pandemic. Specifically, we propose a comprehensive data-driven approach to understand the clinical characteristics of COVID-19, predict its mortality, forecast its evolution, and ultimately alleviate its impact. By leveraging cohort-level clinical data, patient-level hospital data, and census-level epidemiological data, we develop an integrated four-step approach, combining descriptive, predictive and prescriptive analytics. First, we aggregate hundreds of clinical studies into the most comprehensive database on COVID-19 to paint a new macroscopic picture of the disease. Second, we build personalized calculators to predict the risk of infection and mortality as a function of demographics, symptoms, comorbidities, and lab values. Third, we develop a novel epidemiological model to project the pandemic's spread and inform social distancing policies. Fourth, we propose an optimization model to reallocate ventilators and alleviate shortages. Our results have been used at the clinical level by several hospitals to triage patients, guide care management, plan ICU capacity, and re-distribute ventilators. At the policy level, they are currently supporting safe back-to-work policies at a major institution and equitable vaccine distribution planning at a major pharmaceutical company, and have been integrated into the US Center for Disease Control's pandemic forecast. url: https://doi.org/10.1101/2020.06.26.20141127 doi: 10.1101/2020.06.26.20141127 id: cord-313294-ffgo56gl author: Bertsimas, D. title: Personalized Prescription of ACEI/ARBs for Hypertensive COVID-19 Patients date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has prompted an international effort to develop and repurpose medications and procedures to effectively combat the disease. Several groups have focused on the potential treatment utility of angiotensin-converting-enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) for hypertensive COVID-19 patients, with inconclusive evidence thus far. We couple electronic medical record (EMR) and registry data of 3,643 patients from Spain, Italy, Germany, Ecuador, and the US with a machine learning framework to personalize the prescription of ACEIs and ARBs to hypertensive COVID-19 patients. Our approach leverages clinical and demographic information to identify hospitalized individuals whose probability of mortality or morbidity can decrease by prescribing this class of drugs. In particular, the algorithm proposes increasing ACEI/ARBs prescriptions for patients with cardiovascular disease and decreasing prescriptions for those with low oxygen saturation at admission. We show that personalized recommendations can improve patient outcomes by 1.0% compared to the standard of care when applied to external populations. We develop an interactive interface for our algorithm, providing physicians with an actionable tool to easily assess treatment alternatives and inform clinical decisions. This work offers the first personalized recommendation system to accurately evaluate the efficacy and risks of prescribing ACEIs and ARBs to hypertensive COVID-19 patients. url: https://doi.org/10.1101/2020.10.30.20223594 doi: 10.1101/2020.10.30.20223594 id: cord-264073-yhztrscf author: Betonico, Gustavo Navarro title: Challenges in COVID‐19 medical response: a nephrology perspective date: 2020-06-20 words: 1704.0 sentences: 104.0 pages: flesch: 47.0 cache: ./cache/cord-264073-yhztrscf.txt txt: ./txt/cord-264073-yhztrscf.txt summary: 2 Some strategies to minimize the risk of spreading SARS-CoV-2 throughout the dialysis units are simple such as a phone call to the patients just before their HD session asking about any signs of fever or respiratory symptoms. All rights reserved Patients infected with COVID-19 often present clinical markers of kidney injury. 5 According to the available reports, Acute Kidney Injury (AKI) occurs in approximately 3 -15% of patients with COVID-19 infection. 6 Most patients with COVID-19 are affected by mild or asymptomatic renal disease, but those who develop AKI usually share the most severe phenotype of the disease, characterized by cytokine storm, acute lung injury and, eventually, hypercoagulability. 11 In general, dialysis indications in COVID-19 patients follow the same recommendations as in other acute kidney injuries. Management of Patients on Dialysis and With Kidney Transplant During Covid-19 Coronavirus Infection Review Intensive care management of coronavirus disease 2019 ( COVID-19 ): challenges and recommendations abstract: The new coronavirus disease, named by World Health Organization (WHO) as COVID‐19 brought great challenges to patients with end‐stage renal disease (ESRD). In general, ESRD patients have higher number of comorbidities and are at age‐risk for severe pulmonary presentation of this disease. Another important issue is that hemodialysis (HD) clinics are usually not located in small towns, and these frail patients often travel to their dialysis center in groups and also cannot keep the 6‐feet safe distance during their HD session.(1) url: https://doi.org/10.1111/eci.13328 doi: 10.1111/eci.13328 id: cord-299784-xxxdjfbc author: Bettari, Luca title: Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting date: 2020-04-10 words: 747.0 sentences: 59.0 pages: flesch: 47.0 cache: ./cache/cord-299784-xxxdjfbc.txt txt: ./txt/cord-299784-xxxdjfbc.txt summary: title: Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting The correct management of patients with coronavirus disease 2019 and acute coronary syndrome is still uncertain. We describe the percutaneous treatment of an unprotected left main coronary artery in a patient who is positive for coronavirus disease 2019 with unstable angina, dyspnea and fever. The use of the Impella CP cardiac assist system to provide left ventricular support during high-risk percutaneous coronary interventions is recommended in such settings, because its efficacy is supported by randomized@LBettari. Realworld use of the Impella 2.5 circulatory support system in complex high-risk percutaneous coronary intervention: the USpella Registry Supported high-risk percutaneous coronary intervention with the Impella 2.5 device the Europella registry KEY WORDS COVID-19, high-risk PCI, personal protection equipment APPENDIX For supplemental videos, please see the online version of this paper Personal Protection During High-Risk PCI in a COVID-19 Patient abstract: The correct management of patients with coronavirus disease 2019 and acute coronary syndrome is still uncertain. We describe the percutaneous treatment of an unprotected left main coronary artery in a patient who is positive for coronavirus disease 2019 with unstable angina, dyspnea and fever. Particular attention will be dedicated to the measures adopted in the catheterization laboratory to protect the staff and to avoid further spread of the infection. (Level of Difficulty: Intermediate.) url: https://doi.org/10.1016/j.jaccas.2020.03.006 doi: 10.1016/j.jaccas.2020.03.006 id: cord-296440-18vpg419 author: Beurnier, Antoine title: Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation date: 2020-07-30 words: 3554.0 sentences: 206.0 pages: flesch: 49.0 cache: ./cache/cord-296440-18vpg419.txt txt: ./txt/cord-296440-18vpg419.txt summary: The objective of this study was to investigate the characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who required hospitalisation during the spring 2020 outbreak in Paris, France. As the world faces the coronavirus disease 2019 (COVID-19) pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, concerns have arisen about a possible increased risk of asthma exacerbations. In Wuhan, authors pointed out a rate of 0.9% [3] , markedly lower than that in the local population; in another study investigating the clinical characteristics and allergy status of 140 patients infected by SARS-CoV-2 in Wuhan, no patient were reported as being asthmatic [3] . All adult patients hospitalized from March 15, 2020 to April 15, 2020 with a diagnosis of SARS-CoV-2 infection and reporting a history of asthma were included. Moreover, obesity, hypertension and diabetes were the most common comorbidities observed in our cohort of hospitalized asthmatics with COVID-19, which is consistent with earlier research in other patient groups [4] [23] . abstract: BACKGROUND: Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility of asthmatics to develop an exacerbation when they present with severe pneumonia due to SARS-CoV-2 infection is unknown. The objective of this study was to investigate the characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who required hospitalisation during the spring 2020 outbreak in Paris, France. METHODS: A prospective cohort follow-up was carried out from March 15 to April 15, 2020 in Bicêtre Hospital, University Paris-Saclay, France. All hospitalised patients with a SARS-CoV-2 infection who reported a history of asthma were included. RESULTS: Among 768 hospitalised patients, 37 (4.8%) reported a history of asthma, which had been previously confirmed by a pulmonologist in 85% of cases. Patients were mainly female (70%), non-smokers (85%), with a median age of 54 years (interquartile range, IQR 42–67). None of them presented with an asthma exacerbation. Twenty-two (59%) had major comorbidities and 31 (84%) had a body mass index ≥25 kg·m(−2). The most common comorbidities were obesity (36%), hypertension (27%) and diabetes (19%). All patients had a confirmed diagnosis of COVID-19 pneumonia on computed tomography of the chest. Eosinopenia was a typical biologic feature with a median count of 0/mm3 (IQR 0–0). Eleven patients (30%) were admitted in intensive care unit with three death (8.1%) occurring in the context of comorbidities. CONCLUSION: Asthmatics were not overrepresented among patients with severe pneumonia due to SARS-CoV-2 infection who required hospitalisation. Worst outcomes were observed mainly in patients with major comorbidities. url: https://doi.org/10.1183/13993003.01875-2020 doi: 10.1183/13993003.01875-2020 id: cord-006000-ekwpkzqv author: Bewig, B. title: Eosinophilic alveolitis in BAL after lung transplantation date: 1999 words: 4206.0 sentences: 256.0 pages: flesch: 40.0 cache: ./cache/cord-006000-ekwpkzqv.txt txt: ./txt/cord-006000-ekwpkzqv.txt summary: We analyzed 25 BAL samples and clinical data of 4 patients who underwent lung transplantation and presented with recurrent episodes of eosinophilic alveolitis in BAL. We analyzed 25 BAL samples and clinical data of 4 patients who underwent lung transplantation and presented with recurrent episodes of eosinophilic alveolitis in BAL. All patients demonstrated a deterioration of clinical condition, lung function, and blood gas analysis during times of eosinophilia in BAL, compared to previous examinations. In conclusion, eosinophilic alveolitis may indicate acute rejection in patients after lung transplantation, if other causes of eosinophilia are excluded. In conclusion, eosinophilic alveolitis may indicate acute rejection in patients after lung transplantation, if other causes of eosinophilia are excluded. In this retrospective study, clinical data and differential cell counts from BAL samples of 37 lung transplant recipients, who had been treated at the University of Kiel until December 1996 and were available for follow-up investigation, were analyzed. abstract: Lung transplantation has become a therapeutic option for patients with end stage lung disease. However, outcome after transplantation is complicated by episodes of rejection and infections. Bronchoalveolar lavage is a valuable tool in monitoring patients after transplantation, since it allows the detection of pathogens. A marker specifically indicating rejection from changes in BAL fluid has not been found yet. Especially changes in differential cell count, like lymphocytosis or an increase in polymorphnuclear granulocytes, are unspecific. The role of high eosinophil levels in BAL has not been elucidated yet. We analyzed 25 BAL samples and clinical data of 4 patients who underwent lung transplantation and presented with recurrent episodes of eosinophilic alveolitis in BAL. All patients demonstrated a deterioration of clinical condition, lung function, and blood gas analysis during times of eosinophilia in BAL, compared to previous examinations. In all cases, eosinophilia in BAL was accompanied by rejection. All patients were finally treated with high doses of steroids, resulting in improvement of all parameters. Eosinophilia was not associated with significant changes in the IL-5 concentration in BAL or the pattern of IL-5 expression in BAL cells. In conclusion, eosinophilic alveolitis may indicate acute rejection in patients after lung transplantation, if other causes of eosinophilia are excluded. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096104/ doi: 10.1007/s001470050221 id: cord-278937-lkuuftno author: Beydon, N. title: Lung function testing during a pandemic: an international perspective date: 2020-10-11 words: 1872.0 sentences: 105.0 pages: flesch: 47.0 cache: ./cache/cord-278937-lkuuftno.txt txt: ./txt/cord-278937-lkuuftno.txt summary: This review aims to summarize different practices of PFT laboratory management in different countries, including patient appointments, personal protective equipment, testing room requirements and telemedicine during and immediately following the COVID pandemic. Considering that there is a possibility of disease transmission to the patients and staff from asymptomatic carriers, precautions for pulmonary function testing (PFT) laboratories have been controversial (5) . These include postponing testing in non-urgent cases, personal protective equipment (PPE) for the respiratory technicians and PFT lab room characteristics such as negative pressure and adequate ventilation, HEPA filters, extensive hygiene measures and social distancing (6) (7) (8) (9) . At some centers, a negative COVID test is required within 72 hours before performing PFTs. Patients and visitors are expected to have a face mask/covering to enter the hospital. Testing personnel: Respiratory therapists or nurses performing all types of pulmonary function testing are screened daily for COVID symptoms by questionnaires and by temperature measurement in many centers. abstract: The COVID pandemic has passed its first peak for now in many countries while some are still on the rise, with some facing a second wave of cases. Precautions and infection control measures for both pediatric and adult pulmonary function testing (PFT) have been a topic of debate during the pandemic. Many centers had to close their PFT laboratories during the initial periods of the pandemic and are reopening as the numbers of new cases are decreasing. This review aims to summarize different practices of PFT laboratory management in different countries, including patient appointments, personal protective equipment, testing room requirements and telemedicine during and immediately following the COVID pandemic. url: https://www.sciencedirect.com/science/article/pii/S152605422030138X?v=s5 doi: 10.1016/j.prrv.2020.10.001 id: cord-351819-ovpz36e7 author: Beyrouti, Rahma title: Characteristics of ischaemic stroke associated with COVID-19 date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32354768/ doi: 10.1136/jnnp-2020-323586 id: cord-348501-8cvtqj7w author: Beyzaee, Amir Mohammad title: Rituximab as the treatment of pemphigus vulgaris in the COVID‐19 pandemic era: A narrative review date: 2020-10-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Pemphigus vulgaris (PV), an autoimmune blistering disease is treated with immunosuppressive medications. As the immunosuppressive effect of rituximab, the first‐line therapy of PV, lasts more than 6 months, many concerns have raised due to the ongoing novel coronavirus disease (COVID‐19) pandemic. With this background, our objective was to review the currently available literature as well as important websites for the evidence related to rituximab, PV and COVID‐19, adverse effects associated with drugs, and relevant guidelines. “PubMed” and “Google Scholar” database were systematically searched for retrieving all articles related to anti‐CD20 therapy in pemphigus vulgaris and COVID‐19 published up to 14 July 2020. A total of seven clinical studies are performed with anti‐CD20 therapy in COVID‐19, three of which are performed on pemphigus patients, and have shown concerns employing rituximab in patients with COVID‐19. Evidence for treating PV patients with rituximab in COVID‐19 pandemic is limited. Until sufficient evidence or guideline for pemphigus and COVID‐19 treatment is available, we advocate caution commencing rituximab in patients with pemphigus, due to the reported adverse outcomes. url: https://www.ncbi.nlm.nih.gov/pubmed/33051960/ doi: 10.1111/dth.14405 id: cord-016177-fz48wydz author: Bezek, Sarah title: Emergency Triage of Highly Infectious Diseases and Bioterrorism date: 2020-01-03 words: 4381.0 sentences: 189.0 pages: flesch: 35.0 cache: ./cache/cord-016177-fz48wydz.txt txt: ./txt/cord-016177-fz48wydz.txt summary: Emergency medical services are a key element in health systems for the evaluation and treatment of patients exposed to highly infectious diseases or bioterrorism agents. • Developing a case definition for person under investigation • Standardized questions for dispatchers to identify possible infection • Preparation for and evaluation upon arrival on scene by EMS personnel • Precautions while transporting patients and contacting appropriate receiving hospital • Monitoring of potentially exposed EMS personnel • Maintenance of transportation vehicles and equipment • Decontamination processes Similar peer-reviewed frameworks have been proposed for a pandemic of influenza and other respiratory illnesses [4] . Appropriate implementation of these principles can potentially help prevent further spread of disease or agent exposure, initiate appropriate care of ill patients, protect essential EMS responders, and promote efficient use of healthcare resources. abstract: Emergency medical services are a key element in health systems for the evaluation and treatment of patients exposed to highly infectious diseases or bioterrorism agents. Triage and early identification at any point of care can have a significant impact on the prevention and management of these diseases. This chapter reviews triage practices, including early isolation and decontamination, of highly infectious diseases and bioterrorism agents at different health system levels. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120388/ doi: 10.1007/978-3-030-33803-9_3 id: cord-343205-zjw4fbfd author: Bhaskar, Sonu title: Telemedicine as the New Outpatient Clinic Gone Digital: Position Paper From the Pandemic Health System REsilience PROGRAM (REPROGRAM) International Consortium (Part 2) date: 2020-09-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Technology has acted as a great enabler of patient continuity through remote consultation, ongoing monitoring, and patient education using telephone and videoconferencing in the coronavirus disease 2019 (COVID-19) era. The devastating impact of COVID-19 is bound to prevail beyond its current reign. The vulnerable sections of our community, including the elderly, those from lower socioeconomic backgrounds, those with multiple comorbidities, and immunocompromised patients, endure a relatively higher burden of a pandemic such as COVID-19. The rapid adoption of different technologies across countries, driven by the need to provide continued medical care in the era of social distancing, has catalyzed the penetration of telemedicine. Limiting the exposure of patients, healthcare workers, and systems is critical in controlling the viral spread. Telemedicine offers an opportunity to improve health systems delivery, access, and efficiency. This article critically examines the current telemedicine landscape and challenges in its adoption, toward remote/tele-delivery of care, across various medical specialties. The current consortium provides a roadmap and/or framework, along with recommendations, for telemedicine uptake and implementation in clinical practice during and beyond COVID-19. url: https://doi.org/10.3389/fpubh.2020.00410 doi: 10.3389/fpubh.2020.00410 id: cord-344729-sjjedgws author: Bhaskar, Sonu title: Acute Neurological Care in the COVID-19 Era: The Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium Pathway date: 2020-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The management of acute neurological conditions, particularly acute ischemic stroke, in the context of Coronavirus disease 2019 (COVID-19), is of importance, considering the risk of infection to the healthcare workers and patients and emerging evidence of the neuroinvasive potential of the virus. There are variations in expert guidelines further complicating the picture for clinicians in acute settings. In this light, there is a compelling need for further formulation of recommendations that compile these variations seen in the numerous guidelines present. Health system protocols for managing ongoing acute neurological care and intervention need consideration of safety and well-being of the frontline healthcare workers and the patients. We examine existing pathways and their efficacy to mitigate viral exposure to the healthcare workers and patients and synthesize a systemic approach to manage patients with acute neurological conditions in the COVID-19 scenario. Early experiences with a COVID-19 positive stroke patient treated with endovascular thrombectomy is presented to highlight the urgent need for adequate personal protective equipment (PPE) during acute neuro-interventional procedures. url: https://doi.org/10.3389/fneur.2020.00579 doi: 10.3389/fneur.2020.00579 id: cord-335168-3ofarutr author: Bhat, Yasmeen Jabeen title: Impact of COVID-19 Pandemic on Dermatologists and Dermatology Practice date: 2020-05-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has directly or indirectly affected every human being on this planet. It's impact on the healthcare system has been devastating. The medical fraternity across the world, including India, is facing unprecedented challenges in striving to cope up with this catastrophic outbreak. Like all other specialties, dermatology practice has been profoundly affected by this pandemic. Measures have been taken by dermatologists to control the transmission of the virus, whereas providing health care to patients in the constrained environment. Preventive measures such as social distancing and hand hygienic practices along with patient education is being prioritized. Dermatological conferences and events scheduled across the globe in the first half of year 2020 have been either cancelled or postponed to discourage gatherings. Rationalization of resources and practice of teledermatology are being encouraged in current scenario. Non-urgent visits of the patients are being discouraged and elective dermatology procedures are being postponed. Many national and international dermatology societies have recently proposed recommendations and advisories on usage of biologicals and immunomodulators in present context of COVID-19 pandemic. Urticarial, erythematous, varicelliform, purpuric and livedoid rash as well as aggravation of preexisting dermatological diseases like rosacea, eczema, atopic dermatitis, and neurodermatitis rash have been reported in Covid-19 patients. Self medications and poor compliance of dermatology patients in addition to lack of proper treatment protocols and monitoring are a serious concern in the present scenario. Strategies for future course of action, including the dermatology specific guidelines need to be framed. This issue includes a special symposium on dermatology and COVID-19 having recommendations from special interest groups (SIGs) of Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) Academy on leprosy, dermatosurgery, lasers and dermoscopy. url: https://www.ncbi.nlm.nih.gov/pubmed/32695687/ doi: 10.4103/idoj.idoj_180_20 id: cord-311579-4jhoatkw author: Bhatt, Harshil title: Venous thromboembolism and COVID-19: a case report and review of the literature date: 2020-10-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Currently, there is minimal data available highlighting the prevalence of venous thromboembolism in patients infected with coronavirus disease 2019 (COVID-19). This case report with a literature review emphasizes a unique presentation of COVID-19 that is highly important for health care providers to consider when treating their patients. CASE REPORT: A 65-year-old Caucasian male patient presented to the emergency department with a 2-day history of dyspnea on exertion after his wife’s recent diagnosis of COVID-19. He additionally had experienced a couple of episodes of self-resolving diarrhea a few days before presentation. Based on the patient’s clinical presentation and the laboratory workup identifying an elevated D-dimer, a computed tomography angiogram of the chest was obtained, which was significant for moderately large, bilateral pulmonary emboli with a saddle embolus, and an associated small, left lower lobe, pulmonary infarct. Ultrasound of the lower extremity showed non-occlusive deep vein thrombosis at the distal left femoral vein to the left popliteal vein. The patient was additionally diagnosed with COVID-19 when the results of the COVID-19 polymerase chain reaction test returned as positive. The patient was admitted to the COVID unit, and he was started on an intravenously administered, unfractionated heparin drip for management of his bilateral pulmonary emboli and deep vein thrombosis. The patient’s clinical condition improved significantly with anticoagulation, and he was observed in the hospital for 3 days, after which he was discharged home on the enoxaparin bridge with warfarin. Post-discharge telephone calls at day 10 and week 4 revealed that the patient was appropriately responding to anticoagulation treatment and had no recurrence of his symptoms related to venous thromboembolism and COVID-19. CONCLUSION: As COVID-19 continues to lead to significant mortality, more data is emerging that is exposing its perplexing pathogenicity. Meanwhile, the presentation of venous thromboembolism in patients with COVID-19 remains an unusual finding. It is imperative for health care providers to be mindful of this unique association to make necessary diagnostic evaluations and provide appropriate treatment for the patients. url: https://doi.org/10.1186/s13256-020-02516-4 doi: 10.1186/s13256-020-02516-4 id: cord-337665-roelk7i5 author: Bhattacharjee, Hemanga K. title: Emergency Surgery during COVID-19: Lessons Learned date: 2020-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction The ongoing coronavirus disease-2019 (COVID-19) pandemic has disrupted health services throughout the world. It has brought in several new challenges to deal with surgical emergencies. Herein, we report two suspected cases of COVID-19 that were operated during this “lockdown” period and highlight the protocols we followed and lessons we learned from this situation. Result Two patients from “red zones” for COVID-19 pandemic presented with acute abdomen, one a 64-year male, who presented with perforation peritonitis and another, a 57-year male with acute intestinal obstruction due to sigmoid volvulus. They also had associated COVID-19 symptoms. COVID-19 test could not be done at the time of their presentation to the hospital. Patients underwent emergency exploratory laparotomy assuming them to be positive for the infection. Surgical team was donned with full coverall personal protective equipment. Sudden and uncontrolled egression intraperitoneal free gas was avoided, Echelon flex 60 staplers were used to resect the volvulus without allowing the gas from the volvulus to escape; mesocolon was divided using vascular reload of the stapler, no electrosurgical devices were used to avoid the aerosolization of viral particles. Colostomy was done in both the patients. Both the patients turned out to be negative for COVID-19 subsequently and discharged from hospital in stable condition. Conclusion Surgeons need to adapt to safely execute emergency surgical procedures during this period of COVID-19 pandemic. Preparedness is of paramount importance. Full precautionary measures should be taken when dealing with any suspected case. url: https://doi.org/10.1055/s-0040-1716335 doi: 10.1055/s-0040-1716335 id: cord-269425-e9iyso7n author: Bhattacharjee, Sukrita title: Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review date: 2020-09-19 words: 5418.0 sentences: 319.0 pages: flesch: 46.0 cache: ./cache/cord-269425-e9iyso7n.txt txt: ./txt/cord-269425-e9iyso7n.txt summary: A systematic review was done to analyze the clinical profile and outcomes in a total of 45 cases of new-onset ITP in COVID-19 patients described in literature until date. Diagnosis of ITP in patients with moderate-to-severe COVID-19 poses a major diagnostic as well as therapeutic challenge to clinicians owing to presence of multiple concomitant conditions including HLH, DIC, sepsis, antibiotic use, heparin prophylaxis, and thromboembolic events. The following data were extracted from the included studies: age of the patient at presentation, gender, COVID-19 illness severity, comorbidities, medication use, nadir platelet count, onset of COVID-19 symptoms to diagnosis of ITP, bleeding manifestations of ITP, time to recovery from start of treatment, and clinical outcomes. Bone marrow study in these few selected cases of ITP would reveal low number of megakaryocytes, as seen in one patient of this review, who presented with severe thrombocytopenia (count 2 × 10 9 /μL) [7] . abstract: Immune thrombocytopenia, often known as immune thrombocytopenic purpura (ITP), has emerged as an important complication of COVID-19. A systematic review was done to analyze the clinical profile and outcomes in a total of 45 cases of new-onset ITP in COVID-19 patients described in literature until date. A comprehensive approach is essential for diagnosing COVID-19-associated ITP after excluding several concomitant factors that can cause thrombocytopenia in COVID-19. Majority of ITP cases (71%) were found to be elderly (> 50 years) and 75% cases had moderate-to-severe COVID-19. Three patients (7%) were in the pediatric age group. Reports of ITP in asymptomatic COVID-19 patients (7%) underscore the need for COVID-19 testing in newly diagnosed patients with ITP irrespective of COVID-19 symptoms amid this pandemic. ITP onset occurred in 20% cases 3 weeks after onset of COVID-19 symptoms, with many reports after clinical recovery. SARS-CoV-2-mediated immune thrombocytopenia can be attributed to the underlying immune dysregulation, susceptibility mutations in SOCS 1, and other mechanisms, including molecular mimicry, cryptic antigen expression, and epitope spreading. No bleeding manifestations were reported in 31% cases at diagnosis. Severe life-threatening bleeding was uncommon. One case of mortality was attributed to intracranial hemorrhage. Secondary Evans syndrome was diagnosed in one case. Good initial response to short course of glucocorticoids and intravenous immunoglobulin has been found with the exception of delayed lag response in one case. Thrombopoietin receptor agonist usage as a second-line agent has been noted in few cases for short duration with no adverse events. In the relatively short follow-up period, four relapses of ITP were found. url: https://www.ncbi.nlm.nih.gov/pubmed/32984764/ doi: 10.1007/s42399-020-00521-8 id: cord-254419-qw83atrx author: Bhattacharyya, Rajat title: The Interplay Between Coagulation and Inflammation Pathways in COVID-19-Associated Respiratory Failure: A Narrative Review date: 2020-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus disease (COVID-19) pandemic has caused an unprecedented worldwide socio-economic and health impact. There is increasing evidence that a combination of inflammation and hypercoagulable state are the main mechanisms of respiratory failure in these patients. This narrative review aims to summarize currently available evidence on the complex interplay of immune dysregulation, hypercoagulability, and thrombosis in the pathogenesis of respiratory failure in COVID-19 disease. In addition, we will describe the experience of anticoagulation and anti-inflammatory strategies that have been tested. Profound suppression of the adaptive and hyperactivity of innate immune systems with macrophage activation appears to be a prominent feature in this infection. Immune dysregulation together with endotheliitis and severe hypercoagulability results in thromboinflammation and microvascular thrombosis in the pulmonary vasculature leading to severe respiratory distress. Currently, some guidelines recommend the use of prophylactic low molecular weight heparin in all hospitalized patients, with intermediate dose prophylaxis in those needing intensive care, and the use of therapeutic anticoagulation in patients with proven or suspected thrombosis. Strong recommendations cannot be made until this approach is validated by trial results. To target the inflammatory cascade, low-dose dexamethasone appears to be helpful in moderate to severe cases and trials with anti-interleukin agents (e.g., tocilizumab, anakinra, siltuximab) and non-steroidal anti-inflammatory drugs are showing early promising results. Potential newer agents (e.g., Janus kinase inhibitor such as ruxolitinib, baricitinib, fedratinib) are likely to be investigated in clinical trials. Unfortunately, current trials are mostly examining these agents in isolation and there may be a significant delay before evidence-based practice can be implemented. It is plausible that a combination of anti-viral drugs together with anti-inflammatory and anti-coagulation medicines will be the most successful strategy in managing severely affected patients with COVID-19. url: https://doi.org/10.1007/s41030-020-00126-5 doi: 10.1007/s41030-020-00126-5 id: cord-336563-hwemigk7 author: Bhimraj, Adarsh title: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. OBJECTIVE: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. METHODS: IDSA formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and grey literature was conducted. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence and make recommendations. RESULTS: The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations. CONCLUSIONS: The panel expressed the overarching goal that patients be recruited into ongoing trials, which would provide much needed evidence on the efficacy and safety of various therapies for COVID-19, given that we could not make a determination whether the benefits outweigh harms for most treatments. url: https://doi.org/10.1093/cid/ciaa478 doi: 10.1093/cid/ciaa478 id: cord-344765-agt60ksx author: Bhogal, R.H. title: Approach to upper GastroIntestinal cancer surgery during the COVID-19 pandemic – Experience from a UK cancer centre date: 2020-05-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.ejso.2020.05.022 doi: 10.1016/j.ejso.2020.05.022 id: cord-290712-flj352ql author: Bi, Jianping title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? date: 2020-09-04 words: 1345.0 sentences: 90.0 pages: flesch: 49.0 cache: ./cache/cord-290712-flj352ql.txt txt: ./txt/cord-290712-flj352ql.txt summary: title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? Those studies mainly addressed whether chemotherapy could predict for hospitalization, severe disease, and mortality in cancer patients with COVID-19 infection. To address this knowledge gap, this study''s findings suggest that administering chemotherapy to this population is associated with a very low short-term risk of SARS-CoV-2 reactivation. Third, the duration of follow-up in this study was relatively short and it may take a longer period of time to determine immune-related alterations caused by chemotherapy in cancer patients who have recovered from COVID-19 infection. Nevertheless, when conservatively interpreted, our study indicates no overt short-term increase in the risk for SARS-CoV-2 reactivation following immunosuppressive chemotherapy in this uniquely vulnerable population. To our knowledge, this is the first study reporting that recovered COVID-19 cancer patients remain negative in the short-term for SARS-CoV-2 after delivery of chemotherapy. abstract: Recovered COVID-19 cancer patients remain negative for SARS-CoV-2 after delivery of chemotherapy url: https://www.ncbi.nlm.nih.gov/pubmed/32883679/ doi: 10.1183/13993003.02672-2020 id: cord-353698-gj8sx3zy author: Bibiano-Guillen, C. title: Adapted Diving Mask (ADM) device as respiratory support with oxygen output during COVID-19 pandemic date: 2020-10-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0735675720309396?v=s5 doi: 10.1016/j.ajem.2020.10.043 id: cord-018780-zeok60hn author: Biddinger, Paul D. title: Evaluation of the Person Under Investigation date: 2018-07-07 words: 5764.0 sentences: 212.0 pages: flesch: 42.0 cache: ./cache/cord-018780-zeok60hn.txt txt: ./txt/cord-018780-zeok60hn.txt summary: A patient presenting to healthcare facilities with specific clinical and epidemiological risk factors for infection with one of these pathogens may be termed a person under investigation (PUI) for the disease, and healthcare staff should utilize carefully developed protocols and procedures to guide their subsequent isolation and clinical evaluation practices until the disease has been ruled in or out. After the patient has been safely isolated, senior clinic staff must be notified and must contact appropriate subject matter experts for direction on next steps including (1) whether (based on information already available) the patient meets PUI criteria or if additional information is required; (2) if the latter, direction on the safe use of PPE and distancing from the patient; (3) advice on what types of care can safely be provided in that setting for patients confirmed as PUIs; and (4) instructions on transferring the patient to another more appropriate location for further clinical evaluation and management if deemed necessary. abstract: A person under investigation (PUI) is defined as a patient who presents with both clinical and epidemiological risk factors for a specific infectious disease. In the case of infectious diseases that present risks of transmission to healthcare workers (HCWs) and patients, the use of the identify-isolate-inform framework is essential to protect staff and patients and the delivery of safe and effective care. This includes early identification of PUIs, institution of appropriate transmission-based precautions including use of specific personal protective equipment (PPE) and isolation, and prompt notification of relevant personnel, including relevant experts and authorities. Depending on the specific infection suspected, once appropriate infection control measures have been implemented, clinical evaluation of PUIs can vary in complexity. In the case of Ebola virus disease (EVD), the need for specialized PPE and training, well-developed procedures, and dedicated space can be extremely resource-intensive and costly for facilities. In addition, depending upon the need to reduce risks to other patients and HCWs, regular laboratory and imaging equipment may not be available (or available at the standard frequency or turnaround time) to support medical care. Lastly, diagnostic tests needed to confirm the diagnosis may not be available at the healthcare facility and may instead be accessible through public health authorities. This testing may take several days to confirm the diagnosis or rule out the presence of the suspected infection. Thus, the potential period of evaluation for a PUI can extend well beyond a typical clinic or emergency department (ED) visit. Thoughtful and coordinated planning efforts are required across the community and across the hospital to be able to adequately care for the PUI. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123748/ doi: 10.1007/978-3-319-77032-1_12 id: cord-269469-7pmnxi9a author: Bikdeli, Behnood title: Anticoagulation in COVID-19: Randomized trials should set the balance between excitement and evidence date: 2020-10-08 words: 1060.0 sentences: 72.0 pages: flesch: 42.0 cache: ./cache/cord-269469-7pmnxi9a.txt txt: ./txt/cord-269469-7pmnxi9a.txt summary: [10] [11] [12] Such results were embraced by some clinicians and clinical institutions, leading to a change in their routine practice, including recommendations for escalated-dose prophylaxis in all, or some hospitalized patients with COVID-19. Multiple randomized trials have been registered and are at various stages of progress to identify the optimal antithrombotic therapy for outpatients, inpatients, and critically-ill patients with COVID-19. 18 In a pilot single-center study, the authors randomly The authors should be congratulated for completing the first randomized controlled trial of anticoagulant therapy in patients with COVID-19. Anticoagulation, Mortality, Bleeding and Pathology Among Patients Hospitalized with COVID-19: A Single Health System Study Intermediate versus Standard-dose Prophylactic anticoagulation and Statin Therapy versus Placebo in Critically-ill Patients with COVID-19: Rationale and Design of the INSPIRATION/ INSPIRATION-S Studies Anticoagulant interventions in hospitalized patients with COVID-19: A scoping review of randomized controlled trials and call for international collaboration Therapeutic versus prophylactic anticoagulation for severe COVID-19: a randomized phase II clinical trial (HESACOVID) abstract: nan url: https://doi.org/10.1016/j.thromres.2020.09.033 doi: 10.1016/j.thromres.2020.09.033 id: cord-262987-7h91n9ro author: Bin Traiki, Thamer A. title: Impact of COVID-19 pandemic on patient satisfaction and surgical outcomes: A retrospective and cross sectional study date: 2020-08-21 words: 3326.0 sentences: 168.0 pages: flesch: 49.0 cache: ./cache/cord-262987-7h91n9ro.txt txt: ./txt/cord-262987-7h91n9ro.txt summary: OBJECTIVE: The objective of this study was to evaluate the impact of the COVID-19 pandemic on patient satisfaction and surgical outcomes at King Khalid University Hospital in Saudi Arabia. In light of the above, systematized research is needed to understand the change, if any, in the dynamics of patient care, satisfaction, and post-surgical outcomes with regards to revised infrastructure and policies in hospitals in the wake of infectious pandemics like COVID-19. During study period, there were confirmed COVID-19 cases among health care workers (5 cases) and patients (11 cases) in our hospital, and the hospital administration implemented new polices and strict preventative measures to minimize the rate of adverse surgical outcomes among patients, which is also confirmed by the higher level of patient''s satisfaction as detailed above. abstract: OBJECTIVE: The objective of this study was to evaluate the impact of the COVID-19 pandemic on patient satisfaction and surgical outcomes at King Khalid University Hospital in Saudi Arabia. BACKGROUND: The COVID-19 pandemic has greatly affected health care systems across developing and developed countries. Therefore, it is important to understand its impact on various parameters of patient care as regards revised infrastructure and policies in hospitals during the pandemic. METHOD: It is a retrospective cross-sectional study was conducted from 13-3–2020 to 26-4-2020 at King Khalid University Hospital in Saudi Arabia. Patient satisfaction and surgical outcomes were the main outcome measures. RESULTS: 331 participants were included in the study (median age: 53 years; 70% female), and 223 completed the patient's satisfaction survey. 260 of the surgeries were non-oncolog cases (78.6%) compared to 71 oncology cases (21.4%). With respect to the surgical outcomes, 12% of the patients required admission to the ICU, and 10.9% developed postoperative complications, most of which were infectious complications. Only 1.8% (6 patients) were re-admitted to the hospital. Three patients died within 30 days post-op (0.9%), all had emergency surgery. Regarding patient satisfaction, 77.6% and 93% of the patients reported that nurses and doctors, respectively, treated them with courtesy and respect, listened to them carefully, and provided clear explanations to them. 90.3% were satisfied with the hospital sanitary measures. 64.1% stated that they got written instructions at the time of discharge. CONCLUSION: The satisfaction level of patients was high for all the studied domains, and there were a small number of complications with overall good surgical outcomes. That indicates that all the actions and policies that were implemented during the pandemic were proven beneficial for the patients. It is recommended to continue those measures until the COVID-19 pandemic is over. url: https://doi.org/10.1016/j.amsu.2020.08.020 doi: 10.1016/j.amsu.2020.08.020 id: cord-018907-c84t1bo5 author: Bin-Hussain, Ibrahim title: Infections in the Immunocompromised Host date: 2012 words: 3646.0 sentences: 170.0 pages: flesch: 29.0 cache: ./cache/cord-018907-c84t1bo5.txt txt: ./txt/cord-018907-c84t1bo5.txt summary: In providing empirical antibiotic therapy in patient with pulmonary infiltrate and defect in cell-mediated immunity one need to consider Pneumocystis jiroveci, nocardia, legionella, mycoplasma, in addition to aerobic Gram-positive cocci and Gram-negative bacilli therefore it is advised to use trimethoprim-sulfamethoxazole, macrolides including erythromycin or clarithromycin and agent active against Gram-positive and Gram-negative; for example, thirdgeneration cephalosporin with or without aminoglycoside with anti-Gram-positive either nafcillin or vancomycin based on the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and penicillin resistant Streptococcus pneumoniae. The factors influencing antimicrobial selection include the types of bacterial isolates found in the institution, antibiotic susceptibility patterns, drug allergies, presence of organ dysfunction, chemotherapeutic regimen whether the patient was receiving prophylactic antibiotics, and condition of the patient at diagnosis, for example, presence of signs and symptoms at initial evaluation and presence of documented sites requiring additional therapy. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123909/ doi: 10.1007/978-3-642-02202-9_68 id: cord-313728-08kwkbmd author: Binda, Barbara title: Follow-up and Management of Kidney Transplant Recipients During the COVID-19 Lockdown: the experience of an Italian Transplant Center, Including Two Cases of COVID-19 Pneumonia date: 2020-06-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Background COVID-19 is a new infectious disease which emerged in China in late 2019 and is now spreading around the world. Social distancing measures were needed to reduce transmission, and lockdown included restricted access to healthcare facilities. The impact of COVID-19 on transplant recipients is unknown but, considering their immunosuppression status and associated comorbidities, they should be considered a high risk population. Methods A kidney transplant center in Central Italy implemented a strategy to maintain follow-up of kidney transplant recipients by phone and e-mail during lockdown. Telephone interviews were used administer a clinical questionnaire to patients, and e-mail was used to receive the results of diagnostic tests conducted in outpatient settings. Results From March 17 to April 23, 2020, a total of 143 kidney transplant recipients were contacted. Twenty-eight patients needed in-hospital consultation for problems unrelated to COVID-19, 3 of whom needed hospitalization. Eleven patients were managed at home for mild urinary or respiratory diseases, and one was referred to the hematologist. We identified 2 suspected cases of COVID-19 infection, and referred them to hospital care. Immunosuppressive therapy was modulated, and intravenous corticosteroids and potentially effective antiviral therapy were administered, with a favorable outcome. Conclusion In the context of a lockdown, such as that occurring in response to COVID-19, we suggest implementing remote surveillance programs in kidney transplant recipients, with the help of any available technology, and offering medical consulting and logistic support as needed. url: https://api.elsevier.com/content/article/pii/S0041134520325902 doi: 10.1016/j.transproceed.2020.06.026 id: cord-303718-7bpap31f author: Binder, Adam F. title: Treating Hematologic Malignancies During a Pandemic: Utilizing Telehealth and Digital Technology to Optimize Care date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In late January 2020, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) was reported as an outbreak in Wuhan, China. Within 2 months it became a global pandemic. Patients with cancer are at highest risk for both contracting and suffering complications of its resultant disease, Coronavirus 19 (COVID-19). Healthcare systems across the world had to adapt quickly to mitigate this risk, while continuing to provide potentially lifesaving treatment to patients. Bringing care to the home through the use of telehealth, home based chemotherapy, and remote patient monitoring technologies can help minimize risk to the patient and healthcare workers without sacrificing quality of care delivered. These care models provide the right treatment, to the right patient, at the right time, in the right place. Whether these patient-centered models of care will continue to be embraced by key stakeholders after the pandemic remains uncertain. url: https://www.ncbi.nlm.nih.gov/pubmed/32676459/ doi: 10.3389/fonc.2020.01183 id: cord-338146-am5gg1qd author: Bindi, E. title: Meckel's diverticulum perforation in a newborn positive to Sars-Cov-2 date: 2020-08-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The health emergency linked to the Sars-Cov-2 infection represented an absolutely new problem for all health professionals. In particular, the information regarding the spread of the virus in the pediatric field and its manifestations are still incomplete. In this paper we present a case of neonatal infection which, as far as we know, represents one of the few published cases and which occurred in a patient who came to our attention for acute abdomen from intestinal perforation. The perforation was caused by Meckel's diverticulum, an event considered infrequent in the first year of life and almost exceptional in the neonatal period. This case required particular management, putting pediatric surgeons in front of new and difficult to solve problems. New onset clinical events, such as this one described, represent an opportunity for sharing useful data for the creation of universal protocols for the management of patients with problems that are becoming common and of which little is known. url: https://api.elsevier.com/content/article/pii/S221357662030275X doi: 10.1016/j.epsc.2020.101641 id: cord-316306-vfez5k02 author: Bini, Stefano A. title: Digital Orthopaedics. A Glimpse into the Future in The Midst of a Pandemic date: 2020-04-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The response to COVID-19 catalyzed the adoption and integration of digital health tools into the healthcare delivery model for musculoskeletal patients. The change, suspension or relaxation of Medicare and federal guidelines enabled the rapid implementation of these technologies. The expansion of payment models for virtual care facilitated its rapid adoption. The authors aim to provide several examples of digital health solutions utilized to manage orthopaedic patients during the pandemic and discuss what features of these technologies are likely to continue to provide value to patients and clinicians following its resolution. CONCLUSION: The widespread adoption of new technologies enabling providers to care for patients remotely has the potential to permanently change the expectations of all stakeholders about the way care is provided in orthopaedics. The new era of Digital Orthopaedics will see a gradual and non-disruptive integration of technologies that support the patient’s journey through the successful management of their musculoskeletal disease. url: https://www.sciencedirect.com/science/article/pii/S0883540320304356?v=s5 doi: 10.1016/j.arth.2020.04.048 id: cord-337520-qp0ga6q8 author: Binning, Mandy title: Cardiopulmonary resuscitation causing thoracolumbar hyperextension with severe spinal cord injury: A case report date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Thoracic vertebral fractures are extremely rare complications of cardiopulmonary resuscitation (CPR). A morbidly obese 79-year-old female positive for COVID-19 suffered cardiac arrest and received CPR for 18 minutes with return of spontaneous circulation. Post cardiac arrest the patient was unable to be weaned from the ventilator and had decreased lower extremity movement. A computed tomography scan of the chest/abdomen/pelvis demonstrated a widely diastatic spinal separation at the T12/L1 intervertebral disc space with L1 spinous process fracture. The patient ultimately expired from the severe spinal cord injury combined with older age, COVID-19 pneumonia, and morbid obesity. CPR can be an important life-saving procedure, but strict attention to proper technique is of paramount importance as it can have many possible complications. url: https://www.sciencedirect.com/science/article/pii/S1930043320304106 doi: 10.1016/j.radcr.2020.08.017 id: cord-289973-1mczuxsy author: Biran, Noa title: Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study date: 2020-08-14 words: 5218.0 sentences: 271.0 pages: flesch: 41.0 cache: ./cache/cord-289973-1mczuxsy.txt txt: ./txt/cord-289973-1mczuxsy.txt summary: 14 Understanding the limitations of observational studies, but with the urgency to assess potential therapeutic approaches, the 13 hospitals within the Hackensack Meridian Health network (NJ, USA) considered offlabel use of tocilizumab in patients with severe SARSCoV2 infection who required intensive care unit (ICU) support. Adjusted Cox proportional hazards regression models were fitted to estimate the associ ation between tocilizumab use and overall survival, using clini cally likely confounders including age, gender, diabetes, chronic obstructive pulmonary disease (COPD) or asthma, hypertension, cancer, renal failure, obesity, oxygena tion less than 94%, quick Sequential Organ Failure Assessment (qSOFA) score, use of steroids, Creactive protein 15 mg/dL or higher, and intubation or mech anical ven tilator support. Propensity score-matched patients (n=630)* First, we calculated a propensity score of receiv ing tocilizumab treatment for each patient using multi variable logistic regression with the confounders age, gender, diabetes, COPD or asthma, hypertension, cancer, renal failure, obesity, oxygenation less than 94%, qSOFA score, use of steroids, Creactive protein 15 mg/dL or higher, and intubation or mechanical ventilator support. abstract: Summary Background Tocilizumab, a monoclonal antibody directed against the interleukin-6 receptor, has been proposed to mitigate the cytokine storm syndrome associated with severe COVID-19. We aimed to investigate the association between tocilizumab exposure and hospital-related mortality among patients requiring intensive care unit (ICU) support for COVID-19. Methods We did a retrospective observational cohort study at 13 hospitals within the Hackensack Meridian Health network (NJ, USA). We included patients (aged ≥18 years) with laboratory-confirmed COVID-19 who needed support in the ICU. We obtained data from a prospective observational database and compared outcomes in patients who received tocilizumab with those who did not. We applied a multivariable Cox model with propensity score matching to reduce confounding effects. The primary endpoint was hospital-related mortality. The prospective observational database is registered on ClinicalTrials.gov, NCT04347993. Findings Between March 1 and April 22, 2020, 764 patients with COVID-19 required support in the ICU, of whom 210 (27%) received tocilizumab. Factors associated with receiving tocilizumab were patients' age, gender, renal function, and treatment location. 630 patients were included in the propensity score-matched population, of whom 210 received tocilizumab and 420 did not receive tocilizumab. 358 (57%) of 630 patients died, 102 (49%) who received tocilizumab and 256 (61%) who did not receive tocilizumab. Overall median survival from time of admission was not reached (95% CI 23 days–not reached) among patients receiving tocilizumab and was 19 days (16–26) for those who did not receive tocilizumab (hazard ratio [HR] 0·71, 95% CI 0·56–0·89; p=0·0027). In the primary multivariable Cox regression analysis with propensity matching, an association was noted between receiving tocilizumab and decreased hospital-related mortality (HR 0·64, 95% CI 0·47–0·87; p=0·0040). Similar associations with tocilizumab were noted among subgroups requiring mechanical ventilatory support and with baseline C-reactive protein of 15 mg/dL or higher. Interpretation In this observational study, patients with COVID-19 requiring ICU support who received tocilizumab had reduced mortality. Results of ongoing randomised controlled trials are awaited. Funding None. url: https://api.elsevier.com/content/article/pii/S2665991320302770 doi: 10.1016/s2665-9913(20)30277-0 id: cord-305304-d3x734nu author: Birnbaum, Yochai title: Inferior ST-Elevation Myocardial Infarction Presenting When Urgent Primary Percutaneous Coronary Intervention Is Unavailable: Should We Adhere to Current Guidelines? date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The pivotal studies that led to the recommendations for emergent reperfusion therapy for ST-elevation myocardial infarction (STEMI) were conducted for the most part over 25 years ago. At that time, contemporary standard treatments including aspirin, statin, and even anticoagulation were not commonly used. The 2013 American College of Cardiology Foundation (ACCF)/American Heart Association (AHA) guidelines and the 2017 European Society of Cardiology guidelines give a class I recommendation (with the level of evidence A) for primary percutaneous coronary intervention (pPCI) in patients with STEMI and ischemic symptoms of less than 12 h. However, if the patient presents to a hospital without pPCI capacity, and it is anticipated that pPCI cannot be performed within 120 min of first medical contact, fibrinolytic therapy is indicated (if there are no contraindications) (class I indication, level of evidence A). Our review of the pertinent literature shows that the current recommendation for inferior STEMI is based on the level of evidence lower than A. We can consider level B even C, supporting the recommendation for fibrinolytic therapy if pPCI is not available for inferior STEMI. url: https://www.ncbi.nlm.nih.gov/pubmed/32671603/ doi: 10.1007/s10557-020-07039-0 id: cord-318944-13zk6cco author: Bizzoca, Maria Eleonora title: Covid-19 Pandemic: What Changes for Dentists and Oral Medicine Experts? A Narrative Review and Novel Approaches to Infection Containment date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The authors performed a narrative review on Severe Acute Respiratory Syndrome- CoronaVirus-2 ( SARS-CoV-2) and all infectious agents with the primary endpoints to illustrate the most accepted models of safety protocols in dentistry and oral medicine, and to propose an easy view of the problem and a comparison (pre- vs post-COVID19) for the most common dental procedures. The outcome is forecast to help dentists to individuate for a given procedure the differences in terms of safety protocols to avoid infectious contagion (by SARS-CoV-2 and others dangerous agents). An investigation was performed on the online databases Pubmed and Scopus using a combination of free words and Medical Subject Headings (MESH) terms: “dentist” OR “oral health” AND “COVID-19” OR “SARS-CoV-2” OR “coronavirus-19”. After a brief excursus on all infectious agents transmittable at the dental chair, the authors described all the personal protective equipment (PPE) actually on the market and their indications, and on the basis of the literature, they compared (before and after COVID-19 onset) the correct safety procedures for each dental practice studied, underlining the danger of underestimating, in general, dental cross-infections. The authors have highlighted the importance of knowing exactly the risk of infections in the dental practice, and to modulate correctly the use of PPE, in order to invest adequate financial resources and to avoid exposing both the dental team and patients to preventable risks. url: https://www.ncbi.nlm.nih.gov/pubmed/32471083/ doi: 10.3390/ijerph17113793 id: cord-010999-u2guhh3h author: Blackstone, Eric title: Making Medical Decisions for Incapacitated Patients Without Proxies: Part II date: 2019-11-06 words: 6590.0 sentences: 343.0 pages: flesch: 52.0 cache: ./cache/cord-010999-u2guhh3h.txt txt: ./txt/cord-010999-u2guhh3h.txt summary: 2019 ) by providing a qualitative, retrospective look at the process of decision-making for PWPs. Using case examples and excerpts from semi-structured interviews with 12 committee members, we will discuss how the protocol has translated into practice. If no legally acceptable surrogate can be located, the ethics consultant contacts the PWP committee members to recruit 2-3 individuals who can meet with representatives from the medical team within 24-48 h. • Demographic questions (age, sex, religion, education, occupation) • Personal experience in healthcare decision-making (for self or family members) • Member''s assessment of personal qualifications required for committee membership and preparation for role • Member''s experience with PWP cases (mechanics, medical and social information provided, quality of discussion, meeting the patient) • Member''s views on how personal values and religious beliefs affect their decision-making • Member''s experience and views on the post-decision period (second-guessing, need for feedback, debriefing) abstract: In the United States, there is no consensus about who should make decisions in acute but non-emergent situations for incapacitated patients who lack surrogates. For more than a decade, our academic medical center has utilized community volunteers from the hospital ethics committee to engage in shared decision-making with the medical providers for these patients. In order to add a different point of view and minimize conflict of interest, the volunteers are non-clinicians who are not employed by the hospital. Using case examples and interviews with the community members, this paper describes how the protocol has translated into practice over the years since its inception. Members reported comfort with the role as well as satisfaction with the thoroughness of their discussions with the medical team. They acknowledged feelings of moral uncertainty, but expressed confidence in the process. Questions raised by the experience are discussed. Overall, the protocol has provided oversight, transparency, and protection from conflict of interest to the decision-making process for this vulnerable patient population. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223299/ doi: 10.1007/s10730-019-09388-2 id: cord-316938-64jxtg9y author: Blasi, Annabel title: In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: COVID‐19 is associated with a substantial risk of venous thrombotic events, even in the presence of adequate thromboprophylactic therapy. OBJECTIVES: We aimed to better characterize the hypercoagulable state of COVID‐19 patients in patients receiving anticoagulant therapy. METHODS: We took plasma samples of 23 patients with COVID‐19 who were on prophylactic or intensified anticoagulant therapy. Twenty healthy volunteers were included to establish reference ranges. RESULTS: COVID‐19 patients had a mildly prolonged prothrombin time, high VWF levels and low ADAMTS13 activity. Most rotational thromboelastometry parameters were normal, with a hypercoagulable maximum clot firmness in part of the patients. Despite detectable anti‐Xa activity in the majority of patients, ex vivo thrombin generation was normal, and in vivo thrombin generation elevated as evidenced by elevated levels of thrombin‐antithrombin complexes and D‐dimers. Plasma levels of activated factor VII were lower in patients, and levels of the platelet activation marker soluble CD40 ligand were similar in patients and controls. Plasmin‐antiplasmin complex levels were also increased in patients despite an in vitro hypofibrinolytic profile. CONCLUSIONS: COVID‐19 patients are characterized by normal in vitro thrombin generation and enhanced clot formation and decreased fibrinolytic potential despite the presence of heparin in the sample. Anticoagulated COVID‐19 patients have persistent in vivo activation of coagulation and fibrinolysis, but no evidence of excessive platelet activation. Ongoing activation of coagulation despite normal to intensified anticoagulant therapy indicates studies on alternative antithrombotic strategies are urgently required. url: https://www.ncbi.nlm.nih.gov/pubmed/32762118/ doi: 10.1111/jth.15043 id: cord-279197-cesemos0 author: Block, Keith I. title: Integrative Cancer Therapies: Learning From COVID-19 date: 2020-06-21 words: 4112.0 sentences: 228.0 pages: flesch: 40.0 cache: ./cache/cord-279197-cesemos0.txt txt: ./txt/cord-279197-cesemos0.txt summary: Not only has COVID-19 suddenly converted us to a reliance on telehealth that is likely to persist in the future, it has also highlighted the use of some integrative therapies commonly used by cancer patients that have previously been thought to be too controversial for conventional clinics, but that might bear further research attention. For instance, 3 meta-analyses of randomized trials of chemotherapy in colorectal cancer patients found that performance status predicted mortality, [12] [13] [14] in addition to treatment side effects. Along with the previously published beneficial effects of parenteral fish oil emulsions in cancer patients, 30 these vitamin C trials raise the question of the potentials of other unconventional intravenous treatments in cancer patients. Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer abstract: nan url: https://doi.org/10.1177/1534735420932652 doi: 10.1177/1534735420932652 id: cord-279052-8hxdfdls author: Boet, S. title: Protocol for a multicentre randomized controlled trial of normobaric versus hyperbaric oxygen therapy for hypoxemic COVID-19 patients date: 2020-07-16 words: 4123.0 sentences: 247.0 pages: flesch: 46.0 cache: ./cache/cord-279052-8hxdfdls.txt txt: ./txt/cord-279052-8hxdfdls.txt summary: Secondary outcomes will include: (a) clinical outcomes (length of hospital stay, days with oxygen supplementation, oxygen flow values to obtain a saturation by pulse oximetry [≥]90%, intensive care admission and length of stay, days on invasive mechanical ventilation or high flow oxygen, sleep quality, fatigue, major thrombotic events, the 7-level COVID ordinal outcomes scale on Day 28; mortality, safety); (b) biological outcomes (plasma inflammatory markers); and (c) health system outcomes (cost of care and cost-effectiveness). Secondary objectives: To evaluate the effect of HBOT on: (a) other clinical outcomes (i.e., length of hospital stay; days with oxygen supplementation; daily oxygen flow values required to obtain saturation values ≥90%; ICU admission; ICU length of stay; days on invasive mechanical ventilation or high flow oxygenation; major arterial and venous thrombotic events, such as stroke, pulmonary embolism, deep vein thrombosis; sleep quality; fatigue; the 7-level COVID ordinal outcomes scale assessed on Day 28, mortality, and safety; (b) biologic inflammatory markers, including markers of immune activation response and inflammation; and (c) cost of care for COVID-19 patients and cost-effectiveness of HBOT. abstract: Background: At least 1 in 6 COVID-19 patients admitted to hospital and receiving supplemental oxygen will die of complications. More than 50% of patients with COVID-19 that receive invasive treatment such as mechanical ventilation will die in hospital. Such impacts overwhelm the limited intensive care unit resources and may lead to further deaths given inadequate access to care. Hyperbaric oxygen therapy (HBOT) is defined as breathing 100% oxygen at a pressure higher than 1.4 atmosphere absolute (ATA). HBOT is safe, including for lungs, when administered by experienced teams and is routinely administrated for a number of approved indications. Preliminary clinical evidence suggests clinical improvement when hypoxemic COVID-19 patients are treated with HBOT. Objective: We aim to determine the effectiveness of HBOT for improving oxygenation, morbidity, and mortality among hypoxemic COVID-19 patients. Methods and analysis: This trial is a sequential Bayesian Parallel-group, individually Randomized, Open, Blinded Endpoint controlled trial. Admitted hypoxemic COVID-19 patients who require supplemental oxygen (without high flow and mechanical ventilation) to maintain a satisfying tissue oxygenation will be eligible to participate. The anticipated sample size of 234 patients is informed by data from a treatment trial of COVID patients recently published. The intervention group will receive one HBOT per day at 2.0 ATA for 75 minutes. Daily HBOT will be administered until either the patient does not require any oxygen supplementation or requires any type of mechanical ventilation or high flow oxygenation until day 28 post-randomization. Patients in the control group will receive the current standard of care treatment (no HBOT). The primary outcome of this trial will be the 7-level COVID ordinal outcomes scale assessed on Day 7 post-randomization. Secondary outcomes will include: (a) clinical outcomes (length of hospital stay, days with oxygen supplementation, oxygen flow values to obtain a saturation by pulse oximetry [≥]90%, intensive care admission and length of stay, days on invasive mechanical ventilation or high flow oxygen, sleep quality, fatigue, major thrombotic events, the 7-level COVID ordinal outcomes scale on Day 28; mortality, safety); (b) biological outcomes (plasma inflammatory markers); and (c) health system outcomes (cost of care and cost-effectiveness). Predetermined inclusion/exclusion criteria have been specified. The analytical approach for the primary outcome will use a Bayesian proportional odds ordinal logistic semiparametric model. The primary analysis will be by intention-to-treat. Bayesian posterior probabilities will be calculated every 20 patients to assess accumulating evidence for benefit or harm. A planned subgroup analysis will be performed for pre-specified variables known to impact COVID-19 prognosis and/or HBOT (biologic sex and age). Discussion: Based on the mortality rate and substantial burden of COVID-19 on the healthcare system, it is imperative that solutions be found. HBOT is a non-invasive and low-risk intervention when contraindications are respected. The established safety and relatively low cost of providing HBOT along with its potential to improve the prognosis of severe COVID-19 patients make this intervention worth studying, despite the current limited number of HBOT centres. If this trial finds that HBOT significantly improves outcome and prevents further deterioration leading to critical care for severe COVID-19 patients, practice will change internationally. If no benefit is found from the intervention, then the current standard of care (no HBOT) will be supported by level I evidence. url: http://medrxiv.org/cgi/content/short/2020.07.15.20154609v1?rss=1 doi: 10.1101/2020.07.15.20154609 id: cord-324060-vvexfg1c author: Bogdanos, Dimitrios P. title: When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients? date: 2020-03-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The current use of chloroquine and/or hydroxychloroquine, a drug currently used to treat autoimmune rheumatic diseases, in treating severe acute respiratory syndrome caused by coronavirus 2 (SARSCoV-2) or COVID-19-infected patients with pneumonia is a matter of intense consideration. We wish to enter the ongoing debate as to whether this well-known drug must be given to Greek COVID-19-infected patients, especially those with pneumonia. Our arguments are based on the existing data and the capacity of the Greek health system to afford potent anti-viral treatments, which are under immense investigation. We propose several suggestions related to treatment of COVID-19 pneumonia with chloroquine/hydroxychloroquine that we think must be taken into consideration to fit the evolving situation of the pandemic in Greece. url: https://www.ncbi.nlm.nih.gov/pubmed/32411941/ doi: 10.31138/mjr.31.1.94 id: cord-262339-e2ayh108 author: Bohner, Lauren title: 2019-nCoV: Measures Adopted at the Departments of Oral Surgery and Radiology during the Period of an Uncontrolled Transmission Increase date: 2020-06-08 words: 1663.0 sentences: 107.0 pages: flesch: 53.0 cache: ./cache/cord-262339-e2ayh108.txt txt: ./txt/cord-262339-e2ayh108.txt summary: The use of protective equipment and dental office isolation were the major points to avoid the contact between infected and non-infected patients. Thus, preventive measures, such as the use of protection equipment, personal hygiene and ventilated rooms, are essential to avoid contamination [2] . The purpose of this report is to describe the protocol adopted by the Departments of Oral Surgery and Radiology, Hospital University Münster, to avoid the cross infection of professionals and patients during the phase of an uncontrolled transmission increase. Usual measures, such as use of personal protective equipment (PPE) and disinfection protocol after each patient consultation, should be respected. All patients should be considered to be infected, and some aspects must be taken into consideration during the dental treatment: -Patient''s screening, as the avoidance of contact between COVID and non-COVID patients, are important measures to prevent spread of the disease; - abstract: A new mutation of 2019-nCoV emerged and has been spreading worldwide. Dental practices are an important person-to-person transmission route. In this regard, preventive measures are required to avoid the cross contamination among professionals and patients. This report brings recommended measures for dental assistance during the pandemic phase. The clinical protocol applied at the Department of Oral Maxillofacial and Surgery, such as at the Department of Radiology, Hospital University Münster, is described. A management protocol was applied to prevent the transmission route of 2019-nCoV. Patients infected with 2019-nCoV are treated only in emergency situations. The use of protective equipment and dental office isolation were the major points to avoid the contact between infected and non-infected patients. Preventive measures should be taken in order to reduce the spread of 2019-nCoV infection. url: https://www.ncbi.nlm.nih.gov/pubmed/32521726/ doi: 10.3390/dj8020057 id: cord-322052-zsbisk3b author: Bohórquez-Rivero, José title: Letter to the Editor: Humanization of Neurosurgery: Incorporation of a New Concept in Times of COVID-19 date: 2020-08-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.wneu.2020.06.142 doi: 10.1016/j.wneu.2020.06.142 id: cord-312467-kbhljong author: Boilève, Alice title: COVID-19 management in a cancer center: the ICU storm date: 2020-07-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A novel coronavirus, SARS-CoV-2, was first reported as a respiratory illness in December 2019 in Wuhan, China. Since then, the World Health Organization (WHO) Emergency Committee declared a global health. COVID-19 has now spread worldwide and is responsible of more than 472,216 persons, out of 9,100,090 officially diagnosed worldwide since 23 of June. In the context of cancer patients, COVID-19 has a severe impact, regarding pulmonary infection but also cancer treatments in this fragile and immunocompromised population, and ICU admission for cancer patients in the context of COVID-19 requires ethical and clinical consideration. In our cancer center, intensivists, oncologists, pharmacists, and hospital administrators had to prepare for a substantial increase in critical care bed capacity (from 10 ICU beds, 6 medical intensive care beds, and 12 surgical intensive care beds, bed capacity was increased to 28 medical intensive care beds with ventilating capacity) and to adapt infrastructure (i.e., ICU beds), supplies (i.e., drugs, ventilators, protective materials), and staff (i.e., nurses and medical staff). Overall, thirty-three COVID-19 patients were admitted in our ICU, 17 cancer-free and 16 with cancer, and 23 required mechanical ventilation, resulting in 4 deaths (of them two patients with cancer). We report here management of a dedicated intensive care unit of a cancer center during the COVID-19 infection pandemic, considering resource allocation and redistribution of healthcare workers. url: https://doi.org/10.1007/s00520-020-05658-9 doi: 10.1007/s00520-020-05658-9 id: cord-328829-yywxmioq author: Boixeda, Ramon title: Microbiological study of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the usefulness of analytical and clinical parameters in its identification (VIRAE study) date: 2012-05-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Respiratory infection is the most common cause for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD). The aim of this work was to study the etiology of the respiratory infection in order to assess the usefulness of the clinical and analytical parameters used for COPD identification. PATIENTS AND METHODS: We included 132 patients over a period of 2 years. The etiology of the respiratory infection was studied by conventional sputum, paired serology tests for atypical bacteria, and viral diagnostic techniques (immunochromatography, immunofluorescence, cell culture, and molecular biology techniques). We grouped the patients into four groups based on the pathogens isolated (bacterial versus. viral, known etiology versus unknown etiology) and compared the groups. RESULTS: A pathogen was identified in 48 patients. The pathogen was identified through sputum culture in 34 patients, seroconversion in three patients, and a positive result from viral techniques in 14 patients. No significant differences in identifying etiology were observed in the clinical and analytical parameters within the different groups. The most cost-effective tests were the sputum test and the polymerase chain reaction. CONCLUSION: Based on our experience, clinical and analytical parameters are not useful for the etiological identification of COPD exacerbations. Diagnosing COPD exacerbation is difficult, with the conventional sputum test for bacterial etiology and molecular biology techniques for viral etiology providing the most profitability. Further studies are necessary to identify respiratory syndromes or analytical parameters that can be used to identify the etiology of new AE-COPD cases without the laborious diagnostic techniques. url: https://www.ncbi.nlm.nih.gov/pubmed/22745532/ doi: 10.2147/copd.s30568 id: cord-304573-3nhglbw4 author: Bola, Sumrit title: COVID-19 and the return to head and neck outpatient activity in the United Kingdom: what is the new normal? date: 2020-11-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: As surgical specialties now begin the graduated return to elective activity and face-to-face clinics, this paper investigates the current head and neck outpatient practices across the United Kingdom. METHODS: A cross-sectional study comprised of an online 20-item survey was distributed to members of the British Association of Head & Neck Oncologists (BAHNO). The survey was open on a web-based platform and covered topics including safety measures for patients, protective equipment for healthcare staff and protocols for the use of flexible nasendoscopy in the clinic. RESULTS: The survey was completed by 117 participants covering 66 NHS Trusts across the UK. There was a significant reduction in face-to-face Otolaryngology, Maxillofacial and Speech and Language clinic patients when compared to pre-pandemic numbers (p < 0.0001). Risk assessments for flexible nasendoscopy were done for 69% of clinics and 58% had an established protocol. Room downtime after flexible nasendoscopy ranged from 0 to 6 h and there was a significant increase in allocated downtime after a patient had coughed/sneezed (p < 0.001). Natural ventilation existed in 36% of clinics and the majority of responders didn’t know the Air Change Per Hour (ACPH) of the clinic room (77%). Where ACPH was known, it often did not match the allocated room downtime. CONCLUSION: There is a wide variation in outpatient activity across the United Kingdom, but adaptations are being made to try and maintain staff and patient safety. However, more can still be done by liaising with allied teams to clarify outpatient protocols. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00405-020-06458-x) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s00405-020-06458-x doi: 10.1007/s00405-020-06458-x id: cord-294593-mh1uh1b3 author: Boloori, Alireza title: Misalignment of Stakeholder Incentives in the Opioid Crisis date: 2020-10-16 words: 6457.0 sentences: 305.0 pages: flesch: 41.0 cache: ./cache/cord-294593-mh1uh1b3.txt txt: ./txt/cord-294593-mh1uh1b3.txt summary: Some of these issues include the inefficacy of conventional payment mechanisms in providing incentives for providers, practice guidelines in pain management that are not easily implementable across different medical specialties, barriers in adopting multi-modal pain management strategies, low capacity of providers/treatments to address opioid/substance use disorders, the complexity of addressing the co-occurrence of chronic pain and opioid use disorders, and patients'' non-adherence to opioid substitution treatments. These include the implementation of prescription drug monitoring programs [54, 55] , statewide Medicaid program initiatives such as coordinated care organizations [56] [57] [58] , educational outreach and academic detailing for providers [59] [60] [61] , advances in medicine/surgery that lower post-surgical dependence on narcotics [62, 63] , the fentanyl patch-for-patch program [64] , pharmacy consult intervention [65] , quality measure development and/or quality improvement [66] , using data analytics to predict the risk of overdose [67] , and schedule change of opioid analgesics [68] . abstract: The current opioid epidemic has killed more than 446,000 Americans over the past two decades. Despite the magnitude of the crisis, little is known to what degree the misalignment of incentives among stakeholders due to competing interests has contributed to the current situation. In this study, we explore evidence in the literature for the working hypothesis that misalignment rooted in the cost, quality, or access to care can be a significant contributor to the opioid epidemic. The review identified several problems that can contribute to incentive misalignment by compromising the triple aims (cost, quality, and access) in this epidemic. Some of these issues include the inefficacy of conventional payment mechanisms in providing incentives for providers, practice guidelines in pain management that are not easily implementable across different medical specialties, barriers in adopting multi-modal pain management strategies, low capacity of providers/treatments to address opioid/substance use disorders, the complexity of addressing the co-occurrence of chronic pain and opioid use disorders, and patients’ non-adherence to opioid substitution treatments. In discussing these issues, we also shed light on factors that can facilitate the alignment of incentives among stakeholders to effectively address the current crisis. url: https://doi.org/10.3390/ijerph17207535 doi: 10.3390/ijerph17207535 id: cord-254040-s3k51rkk author: Bombaci, Alessandro title: Telemedicine for management of patients with amyotrophic lateral sclerosis through COVID-19 tail date: 2020-10-06 words: 2142.0 sentences: 104.0 pages: flesch: 37.0 cache: ./cache/cord-254040-s3k51rkk.txt txt: ./txt/cord-254040-s3k51rkk.txt summary: In this context, patients affected by chronic neurological diseases, such as amyotrophic lateral sclerosis (ALS), are at risk to be lost at follow-up, leading to a higher risk of morbidity and mortality. In this context, patients affected by chronic neurological diseases, such as amyotrophic lateral sclerosis (ALS), are at risk of being lost at follow-up with a consequently higher morbidity and mortality. Neurological examination and ALS Functional Rating Scale revised (ALSFRSr) are the most important tools to monitor disease progression. In a recent randomized trial comparing remote nutritional counseling with or without mobile health technology in ALS patients, Nu Planit application was an acceptable and useful mobile app to check nutritional status [17] . In conclusion, implementing telemedicine services for patients with ALS is necessary to allow direct clinical evaluation during COVID-19 pandemic, in order to plan the appropriate medical and nursing care, avoiding hospitalizations or urgent interventions. Telemedicine for patients with amyotrophic lateral sclerosis during COVID-19 pandemic: an Italian ALS referral center experience abstract: Over the last months, due to coronavirus disease (COVID-19) pandemic, containment measures have led to important social restriction. Healthcare systems have faced a complete rearrangement of resources and spaces, with the creation of wards devoted to COVID-19 patients. In this context, patients affected by chronic neurological diseases, such as amyotrophic lateral sclerosis (ALS), are at risk to be lost at follow-up, leading to a higher risk of morbidity and mortality. Telemedicine may allow meet the needs of these patients. In this commentary, we briefly discuss the digital tools to remotely monitor and manage ALS patients. Focusing on detecting disease progression and preventing life-threatening conditions, we propose a toolset able to improve ALS management during this unprecedented situation. url: https://www.ncbi.nlm.nih.gov/pubmed/33025327/ doi: 10.1007/s10072-020-04783-x id: cord-016601-gp259urb author: Bonadonna, Lucia title: Analysis of Microorganisms in Hospital Environments and Potential Risks date: 2017-03-24 words: 3523.0 sentences: 192.0 pages: flesch: 32.0 cache: ./cache/cord-016601-gp259urb.txt txt: ./txt/cord-016601-gp259urb.txt summary: Hospital environments are characterized by high infective risk, firstly cause of the compromised immunologic conditions of the patients that make them vulnerable to bacterial, viral, parasitological and fungal opportunistic infections (D''Alessandro et al. The potential transmission of biological matter during surgery operations and medical treatments of infected individuals makes hospital environments strongly designated to become easily contaminated with spread of pathogens among patients (Baglioni and Capolongo 2002) . In addition, technological devices such as hydraulic, heating and air-conditioning systems may represent a potential source of bacteria, fungi (moulds), virus and other organisms if not adequately designed and submitted to a planned preventive maintenance. These difficulties are exacerbated in hospitals where the patient health status, the activities that take place and the potential spread of pathogenic biological agents increase the level of complexity respect to other indoor environments. abstract: This report provides information on indoor air quality and on associated potential risks in hospitals. Spread and persistence of microbial communities in hospital environments are of huge interest to public health. Hospitals are characterized by high infective risk, firstly cause of the compromised immunologic conditions of the patients that make them vulnerable to bacterial, viral, parasitological and fungal opportunistic infections. Evidence suggests that microbial agents spread through air, surfaces, aerosol and hands. If surfaces may act as a reservoir for some pathogens, hands are an important transmission route. Airborne and aerosolized waterborne microorganisms are taken into consideration, and their presence into the hospital environments is reviewed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120946/ doi: 10.1007/978-3-319-49160-8_5 id: cord-331547-uqmjhhna author: Bonalumi, Giorgia title: A call to action becomes practice: cardiac and vascular surgery during the COVID-19 pandemic based on the Lombardy emergency guidelines date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: During the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic, Northern Italy had to completely reorganize its hospital activity. In Lombardy, the hub-and-spoke system was introduced to guarantee emergency and urgent cardiovascular surgery, whereas most hospitals were dedicated to patients with coronavirus disease 2019 (COVID-19). The aim of this study was to analyse the results of the hub-and-spoke organization system. METHODS: Centro Cardiologico Monzino (Monzino) became one of the four hubs for cardiovascular surgery, with a total of eight spokes. SARS-CoV-2 screening became mandatory for all patients. New flow charts were designed to allow separated pathways based on infection status. A reorganization of spaces guaranteed COVID-19-free and COVID-19-dedicated areas. Patients were also classified into groups according to their pathological and clinical status: emergency, urgent and non-deferrable (ND). RESULTS: A total of 70 patients were referred to the Monzino hub-and-spoke network. We performed 41 operations, 28 (68.3%) of which were emergency/urgent and 13 of which were ND. The screening allowed the identification of COVID-19 (three patients, 7.3%) and non-COVID-19 patients (38 patients, 92.7%). The newly designed and shared protocols guaranteed that the cardiac patients would be divided into emergency, urgent and ND groups. The involvement of the telematic management heart team allowed constant updates and clinical discussions. CONCLUSIONS: The hub-and-spoke organization system efficiently safeguards access to heart and vascular surgical services for patients who require ND, urgent and emergency treatment. Further reorganization will be needed at the end of this pandemic when elective cases will again be scheduled, with a daily increase in the number of operations. url: https://www.ncbi.nlm.nih.gov/pubmed/32584978/ doi: 10.1093/ejcts/ezaa204 id: cord-268326-sbz3uk5h author: Bonam, Srinivasa Reddy title: Lysosomes as a therapeutic target date: 2019-09-02 words: 17899.0 sentences: 839.0 pages: flesch: 37.0 cache: ./cache/cord-268326-sbz3uk5h.txt txt: ./txt/cord-268326-sbz3uk5h.txt summary: With a focus on lysosomal dysfunction in autoimmune disorders and neurodegenerative diseases — including lupus, rheumatoid arthritis, multiple sclerosis, Alzheimer disease and Parkinson disease — this Review critically analyses progress and opportunities for therapeutically targeting lysosomal proteins and processes, particularly with small molecules and peptide drugs. Alterations in lysosomal functions, either in the fusion processes involved in the general pathways mentioned above or related to the function of lyso somal enzymes and non enzymatic proteins, can result in broad detrimental effects, including failure to clear potentially toxic cellular waste, inflammation, apopto sis and dysregulation of cellular signalling 8 . abstract: Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme replacement therapy has proved successful. Growing evidence also implicates roles for lysosomal dysfunction in more common diseases including inflammatory and autoimmune disorders, neurodegenerative diseases, cancer and metabolic disorders. With a focus on lysosomal dysfunction in autoimmune disorders and neurodegenerative diseases — including lupus, rheumatoid arthritis, multiple sclerosis, Alzheimer disease and Parkinson disease — this Review critically analyses progress and opportunities for therapeutically targeting lysosomal proteins and processes, particularly with small molecules and peptide drugs. url: https://doi.org/10.1038/s41573-019-0036-1 doi: 10.1038/s41573-019-0036-1 id: cord-332480-3uodkrkp author: Bonam, Srinivasa Reddy title: Adjunct immunotherapies for the management of severely ill COVID-19 patients date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has infected millions with more than 181,000 fatal cases as of 22nd April 2020. Currently, there are no specific COVID-19 therapies. Most patients depend on mechanical ventilation. Current COVID-19 data clearly highlight that cytokine storm and activated immune cell migration to the lungs characterize the early immune response to COVID-19 that causes severe lung damage and development of acute respiratory distress syndrome. In view of uncertainty associated with immunosuppressive treatments such as corticosteroids and their possible secondary effects, including risks of secondary infections, we suggest immunotherapies as an adjunct therapy in severe COVID-19 cases. Such immunotherapies based on inflammatory cytokine neutralization, immunomodulation and passive viral neutralization, not only reduce inflammation, inflammation-associated lung damage, or viral load, but could also prevent intensive care unit hospitalization and dependency on mechanical ventilation both of which are limited resources. url: https://www.ncbi.nlm.nih.gov/pubmed/32562483/ doi: 10.1016/j.xcrm.2020.100016 id: cord-005819-fp5khzd5 author: Bonatz, K. title: Gram-negative bacterial pneumonia with secondary aspergillosis in an AIDS patient date: 1991 words: 1651.0 sentences: 109.0 pages: flesch: 36.0 cache: ./cache/cord-005819-fp5khzd5.txt txt: ./txt/cord-005819-fp5khzd5.txt summary: title: Gram-negative bacterial pneumonia with secondary aspergillosis in an AIDS patient After the initial success of therapy and a symptom-free period, she developed pneumonia with septic shock and adult respiratory distress syndrome (ARDS). The largest study of invasive aspergillosis so far, with 13 HIV-infected patients, documents the diagnostic difficulties, as positive diagnosis mostly required bronchoalveolar lavage or transthoracic aspiration of pulmonary lesions. The cases of AIDS patients with invasive aspergillosis described in the literature therefore had neutropenia related to zidovudine or to ganciclovir therapy, increased exposure to aspergillus by marijuana smoking, underlying pulmonary disease, or corticosteroid use as predisposing factors. It also indicates the possibility of increasing confrontation with disseminated fungal infections like invasive aspergillosis as secondary neutropenia due to drugs such as zidovudine and ganciclovir becomes more common. Bacterial pneumonia in patients with human immunodeficiency virus infection Aspergillus endocarditis and myocarditis in a patient with the acquired immunodeficiency syndrome (AIDS) Bacterial infections in AIDS patients abstract: A 40-year-old, HIV-infected female patient received antibiotic treatment for a urinary tract infection. After the initial success of therapy and a symptom-free period, she developed pneumonia with septic shock and adult respiratory distress syndrome (ARDS). In spite of intensive care and respirator therapy with positive end-expiratory pressure (PEEP), she died of infectious toxic shock. Autopsy findings showed relapsing, gramnegative, bacterial pneumonia (morphologically compatible with Klebsiella pneumonia) and secondary, invasive aspergillosis. The pathogenesis and epidemiology of these unusual complications of AIDS are discussed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095790/ doi: 10.1007/bf01649459 id: cord-277096-zvb7n9wo author: Bond, David A. title: Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date: 2018-11-29 words: 3709.0 sentences: 179.0 pages: flesch: 41.0 cache: ./cache/cord-277096-zvb7n9wo.txt txt: ./txt/cord-277096-zvb7n9wo.txt summary: 7 cHL is characterized by a relatively small proportion of pathologic Reed-Sternberg (RS) cells within a reactive inflammatory milieu and is associated with a state of increased Clinical Practice Points ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) is a widely used front-line regimen for the treatment of early and advanced stage classical Hodgkin lymphoma (cHL). We identified 3 patients experiencing febrile hypotensive reactions following ABVD chemotherapy at our institution with shared baseline clinical features, including stage IVB disease, high risk disease by International Prognostic Score, male gender, and Epstein-Barr virus-positive cHL. 15 Subsequent cases of fatal or life-threatening febrile, hypotensive reactions in patients with lymphoma treated with bleomycin as part of multi-agent therapy have been reported, [16] [17] [18] [19] including a patient with a febrile, hypotensive reaction following treatment with ABVD associated with tumor lysis syndrome (TLS) and markedly elevated serum IL-6. abstract: nan url: https://api.elsevier.com/content/article/pii/S2152265018315817 doi: 10.1016/j.clml.2018.11.020 id: cord-346276-1dcp05rd author: Bonfá, Eloisa title: How COVID-19 is changing rheumatology clinical practice date: 2020-11-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The emergence of COVID-19 in early 2020 led to unprecedented changes to rheumatology clinical practice worldwide, including the closure of research laboratories, the restructuring of hospitals and the rapid transition to virtual care. As governments sought to slow and contain the spread of the disease, rheumatologists were presented with the difficult task of managing risks, to their patients as well as to themselves, while learning and implementing new systems for remote health care. Consequently, the COVID-19 pandemic led to a transformation in health infrastructures and telemedicine that could become powerful tools for rheumatologists, despite having some limitations. In this Viewpoint, five experts from different regions discuss their experiences of the pandemic, including the most challenging aspects of this unexpected transition, the advantages and limitations of virtual visits, and potential opportunities going forward. url: https://doi.org/10.1038/s41584-020-00527-5 doi: 10.1038/s41584-020-00527-5 id: cord-273945-b1lekw47 author: Bongiovanni, Alberto title: Comment on ‘Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey” by Alice Indini et al. date: 2020-05-16 words: 606.0 sentences: 37.0 pages: flesch: 47.0 cache: ./cache/cord-273945-b1lekw47.txt txt: ./txt/cord-273945-b1lekw47.txt summary: title: Comment on ''Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey" by Alice Indini et al. Comment on ''Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey" by Alice Indini et al. In this scenario a multidisciplinary approach is useful because it permits a more accurate identification of SRE risk , avoiding unnecessary medical visits, orienting patients towards the right procedure/treatment, reducing contact with healthcare operators and consequently lowering the risk of COVID-19 contamination even if the multidisciplinary meeting seems to be contraindicated. However, in the present COVID-19 emergency greater emphasis is needed on risk assessment, prevention strategies and effective therapies in order to optimise oncologic resources and to guarantee the patients'' continuum of care. We believe our experience could provide a feasible model of care to manage BM patient and at the same time prevent and reduce COVID-19 infection. abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0959804920302446?v=s5 doi: 10.1016/j.ejca.2020.04.047 id: cord-339406-81a7fkpj author: Borghi, M. O. title: Prevalence, specificity, and clinical association of anti-phospholipid antibodies in COVID-19 patients: are the antibodies really guilty? date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. Critically ill patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state and often develop coagulopathy which leads to organ failure and death. Because of a prolonged activated partial-thromboplastin time (aPTT), a relationship with anti-phospholipid antibodies (aPL) has been proposed, but results are controversial. Functional assays for aPL (i.e., lupus anticoagulant) can be influenced by concomitant anticoagulation and/or high levels of C reactive protein. The presence of anti-cardiolipin (aCL), anti-beta2-glycoprotein I (anti-{beta}2GPI and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies was not investigated systematically. Epitope specificity of anti-{beta}2GPI antibodies was not reported. Aim. To evaluate the prevalence and the clinical association of aPL in a large cohort of COVID-19 patients, and to characterize the epitope specificity of anti-{beta}2GPI antibodies. Methods. ELISA and chemiluminescence assays were used to test 122 sera of patients suffering from severe COVID-19. Of them, 16 displayed major thrombotic events. Results. Anti-{beta}2GPI IgG/IgA/IgM were the most frequent in 15.6/6.6/9.0% of patients, while aCL IgG/IgM were detected in 5.7/6.6% by ELISA. Comparable values were found by chemiluminescence. aPS/PT IgG/IgM were detectable in 2.5 and 9.8% by ELISA. No association between thrombosis and aPL was found. Reactivity against domain 1 and 4-5 of {beta}2GPI was limited to 3/58 (5.2%) tested sera for each domain and did not correlate with aCL/anti-{beta}2GPI nor with thrombosis. Conclusion. aPL show a low prevalence in COVID-19 patients and are not associated with major thrombotic events. aPL in COVID-19 patients are mainly directed against {beta}2GPI but display an epitope specificity different from antibodies in antiphospholipid syndrome. url: https://doi.org/10.1101/2020.06.17.20134114 doi: 10.1101/2020.06.17.20134114 id: cord-031821-rywdkqcd author: Borregón Rivilla, Miguel title: Coronavirus infection in cancer patients, last update() date: 2020-09-12 words: 2134.0 sentences: 115.0 pages: flesch: 50.0 cache: ./cache/cord-031821-rywdkqcd.txt txt: ./txt/cord-031821-rywdkqcd.txt summary: In relation to the data we have on the behaviour of the coronavirus pandemic in cancer patients, there are many studies that are being carried out and few already published. The symptomatology has been the usual one observed in the general population with coronavirus infection, highlighting dyspnoea as the main symptom that defines seriously ill patients. The low percentage of the population of cancer patients must be taken into account in most studies, limiting the interpretation that can be made of these data. We hope that clinical and therapeutic studies of coronavirus infection will soon emerge, to shed light on the health crisis we are experiencing. Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan Clinical characteristics and prognosis in cancer patients with COVID-19: A single center''s retrospective study A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486851/ doi: 10.1016/j.medcle.2020.05.021 id: cord-275518-p03sl946 author: Borsa, Stefano title: Call of duty: neuro-oncology outpatient management during the COVID-19 pandemic in Milan, ITALY date: 2020-07-10 words: 752.0 sentences: 64.0 pages: flesch: 62.0 cache: ./cache/cord-275518-p03sl946.txt txt: ./txt/cord-275518-p03sl946.txt summary: title: Call of duty: neuro-oncology outpatient management during the COVID-19 pandemic in Milan, ITALY Our hospital''s neuro-oncological outpatient clinic is a tertiary center for brain tumor patients, with a regular workload of 15 patients/week. Since the SARS-CoV-2 outbreak reached the pandemic status, our hospital was identified as a COVID-19 referral center. Within the framework of the emergent plan re-organizing the regional health-care system, we were able to operate 3-4 patients with brain tumors per week and to guarantee neuro-oncological visits three times per week. As a further measure to limit the patients'' accesses to the outpatient clinic, we encouraged the use of e-mails, telephone, and image-transfer tools to provide continuity of care. Such a multidisciplinary effort may enhance our response to the pandemic and contribute to the development of shared guidelines for modifying the approach to patients'' follow-up, as it is already emerging in other medical fields 5 Neuro-oncology Management During the COVID-19 abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32647891/ doi: 10.1093/neuonc/noaa164 id: cord-284332-p4c1fneh author: Bosma, Karen J. title: Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date: 2012-09-19 words: 14516.0 sentences: 721.0 pages: flesch: 37.0 cache: ./cache/cord-284332-p4c1fneh.txt txt: ./txt/cord-284332-p4c1fneh.txt summary: [47] Although both of these studies were conducted prior to the 1994 AECC definition, ARDS was strictly defined in the aforementioned studies, including a PaO 2 /FiO 2 ratio <150 or intrapulmonary shunt >20% in patients requiring mechanical ventilation and who had diffuse infiltrates on chest radiograph without clinical evidence of heart failure as pulmonary arterial occlusion pressures were <18 mmHg. Building on the results of these two studies, Sinuff and colleagues [48] developed practice guidelines for prophylactic ketoconazole use, and tested the implementation and efficacy of these guidelines in two ICUs (one control and one active comparator). [119] A phase II study enrolling 98 patients with ALI compared an antioxidant enteral feeding formula containing eicosapentaenoic acid, g-linolenic acid and antioxidant vitamins with placebo, and observed improved oxygenation, reduced pulmonary inflammation, fewer days of mechanical ventilation and fewer non-pulmonary organ failures in the treatment arm, although there was no difference in mortality between this approach and the control group. abstract: The acute respiratory distress syndrome (ARDS) arises from direct and indirect injury to the lungs and results in a life-threatening form of respiratory failure in a heterogeneous, critically ill patient population. Critical care technologies used to support patients with ARDS, including strategies for mechanical ventilation, have resulted in improved outcomes in the last decade. However, there is still a need for effective pharmacotherapies to treat ARDS, as mortality rates remain high. To date, no single pharmacotherapy has proven effective in decreasing mortality in adult patients with ARDS, although exogenous surfactant replacement has been shown to reduce mortality in the paediatric population with ARDS from direct causes. Several promising therapies are currently being investigated in preclinical and clinical trials for treatment of ARDS in its acute and subacute, exudative phases. These include exogenous surfactant therapy, β(2)-adrenergic receptor agonists, antioxidants, immunomodulating agents and HMG-CoA reductase inhibitors (statins). Recent research has also focused on prevention of acute lung injury and acute respiratory distress in patients at risk. Drugs such as captopril, rosiglitazone and incyclinide (COL-3), a tetracycline derivative, have shown promising results in animal models, but have not yet been tested clinically. Further research is needed to discover therapies to treat ARDS in its late, fibroproliferative phase. Given the vast number of negative clinical trials to date, it is unlikely that a single pharmacotherapy will effectively treat all patients with ARDS from differing causes. Future randomized controlled trials should target specific, more homogeneous subgroups of patients for single or combination therapy. url: https://www.ncbi.nlm.nih.gov/pubmed/20568833/ doi: 10.2165/10898570-000000000-00000 id: cord-349329-f0pbd968 author: Bosteels, Cedric title: Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The hypothesis of the proposed intervention is that Granulocyte-macrophage colony-stimulating factor (GM-CSF) has profound effects on antiviral immunity, and can provide the stimulus to restore immune homeostasis in the lung with acute lung injury post COVID-19, and can promote lung repair mechanisms, that lead to a 25% improvement in lung oxygenation parameters. Sargramostim is a man-made form of the naturally-occurring protein GM-CSF. TRIAL DESIGN: A phase 4 academic, prospective, 2 arm (1:1 ratio), randomized, open-label, controlled trial. PARTICIPANTS: Patients aged 18-80 years admitted to specialized COVID-19 wards in 5 Belgian hospitals with recent (< 2 weeks prior to randomization) confirmed COVID-19 infection and acute respiratory failure defined as a PaO2/FiO2 below 350 mmHg or SpO2 below 93% on minimal 2 L/min supplemental oxygen. Patients were excluded from the trial in case of (1) known serious allergic reactions to yeast-derived products, (2) lithium carbonate therapy, (3) mechanical ventilation prior to randomization, (4) peripheral white blood cell count above 25.000/μL and/or active myeloid malignancy, (5) high dose systemic steroid therapy (> 20 mg methylprednisolone or equivalent), (6) enrolment in another investigational study, (7) pregnant or breastfeeding or (8) ferritin levels > 2000 μg/mL. INTERVENTION AND COMPARATOR: Inhaled sargramostim 125 μg twice daily for 5 days in addition to standard care. Upon progression of disease requiring mechanical ventilation or to acute respiratory distress syndrome (ARDS) and initiation of mechanical ventilator support within the 5 day period, inhaled sargramostim will be replaced by intravenous sargramostim 125 μg/m(2) body surface area once daily until the 5 day period is reached. From day 6 onwards, progressive patients in the active group will have the option to receive an additional 5 days of IV sargramostim, based on the treating physician's assessment. Intervention will be compared to standard of care. Subjects progressing to ARDS and requiring invasive mechanical ventilatory support, from day 6 onwards in the standard of care group will have the option (clinician's decision) to initiate IV sargramostim 125m μg/m(2) body surface area once daily for 5 days. MAIN OUTCOMES: The primary endpoint of this intervention is measuring oxygenation after 5 days of inhaled (and intravenous) treatment through assessment of a change in pretreatment and post-treatment ratio of PaO2/FiO2 and through measurement of the P(A-a)O2 gradient (PAO2= Partial alveolar pressure of oxygen, PaO2=Partial arterial pressure of oxygen; FiO2= Fraction of inspired oxygen). RANDOMISATION: Patients will be randomized in a 1:1 ratio. Randomization will be done using REDCap (electronic IWRS system). BLINDING (MASKING): In this open-label trial neither participants, caregivers, nor those assessing the outcomes will be blinded to group assignment. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): A total of 80 patients with confirmed COVID-19 and acute hypoxic respiratory failure will be enrolled, 40 in the active and 40 in the control group. TRIAL STATUS: SARPAC protocol Version 2.0 (April 15 2020). Participant recruitment is ongoing in 5 Belgian Hospitals (i.e. University Hospital Ghent, AZ Sint-Jan Bruges, AZ Delta Roeselare, University Hospital Brussels and ZNA Middelheim Antwerp). Participant recruitment started on March 26(th) 2020. Given the current decline of the COVID-19 pandemic in Belgium, it is difficult to anticipate the rate of participant recruitment. TRIAL REGISTRATION: The trial was registered on Clinical Trials.gov on March 30(th), 2020 (ClinicalTrials.gov Identifier: NCT04326920) - retrospectively registered; https://clinicaltrials.gov/ct2/show/NCT04326920?term=sarpac&recrs=ab&draw=2&rank=1 and on EudraCT on March 24th, 2020 (Identifier: 2020-001254-22). FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://www.ncbi.nlm.nih.gov/pubmed/32503663/ doi: 10.1186/s13063-020-04451-7 id: cord-317952-4oa9hfb4 author: Bourgonje, Arno R. title: Angiotensin‐converting enzyme‐2 (ACE2), SARS‐CoV‐2 and pathophysiology of coronavirus disease 2019 (COVID‐19) date: 2020-05-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Angiotensin‐converting enzyme‐2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus responsible for the current devastating worldwide pandemic of coronavirus disease 2019 (COVID‐19). ACE2 is abundantly expressed in a variety of cells residing in many different human organs. In human physiology, ACE2 is a pivotal counter‐regulatory enzyme to ACE by the breakdown of angiotensin II, the central player in the renin‐angiotensin‐aldosterone system (RAAS) and the main substrate of ACE2. Many factors have been associated with both altered ACE2 expression and COVID‐19 severity and progression, including age, sex, ethnicity, medication and several co‐morbidities, such as cardiovascular disease and metabolic syndrome. Although ACE2 is widely distributed in various human tissues and many of its determinants have been well recognised, ACE2‐expressing organs do not equally participate in COVID‐19 pathophysiology, implying that other mechanisms are involved in orchestrating cellular infection resulting in tissue damage. Reports of pathologic findings in tissue specimens of COVID‐19 patients are rapidly emerging and confirm the established role of ACE2 expression and activity in disease pathogenesis. Identifying pathologic changes caused by SARS‐CoV‐2 infection is crucially important as it has major implications for understanding COVID‐19 pathophysiology and the development of evidence‐based treatment strategies. Currently, many interventional strategies are being explored in ongoing clinical trials, encompassing many drug classes and strategies, including antiviral drugs, biological response modifiers and RAAS inhibitors. Ultimately, prevention is key to combat COVID‐19 and appropriate measures are being taken accordingly, including development of effective vaccines. In this review, we describe the role of ACE2 in COVID‐19 pathophysiology, including factors influencing ACE2 expression and activity in relation to COVID‐19 severity. In addition, we discuss the relevant pathological changes resulting from SARS‐CoV‐2 infection. Finally, we highlight a selection of potential treatment modalities for COVID‐19. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/path.5471 doi: 10.1002/path.5471 id: cord-268886-mpceglk1 author: Bourne, T. title: ISUOG Consensus Statement on rationalization of gynecological ultrasound services in context of SARS‐CoV‐2 date: 2020-04-08 words: 3086.0 sentences: 198.0 pages: flesch: 46.0 cache: ./cache/cord-268886-mpceglk1.txt txt: ./txt/cord-268886-mpceglk1.txt summary: Given the challenges of the current coronavirus (SARS-CoV-2) pandemic and to protect both patients and ultrasound providers (physicians, sonographers, allied professionals), the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) has compiled the following expert-opinion-based guidance for the rationalization of ultrasound investigations for gynecological indications. While these are extremely troublesome conditions, patients and healthcare providers should consider delaying ultrasound evaluation until resolution of the COVID-19 pandemic. Although associated symptoms (mass effect leading to pressure, bladder/bowel symptoms) are not usually acute or life-threatening, they may signal advanced ovarian cancer, in which case, it may be reasonable to recommend that ultrasound assessment should be carried out by an expert soon and appropriate treatment commenced. • Abdominopelvic ''mass'' without associated symptoms (SOON or LATER): the healthcare provider may consider delaying the ultrasound evaluation until the resolution of the pandemic if there is a known history of pelvic pathology, such as leiomyoma. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32267984/ doi: 10.1002/uog.22047 id: cord-324635-27q3nxte author: Bouza, Emilio title: The situation of infection in the elderly in Spain: a multidisciplinary opinion document date: 2020-09-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Infection in the elderly is a huge issue whose treatment usually has partial and specific approaches. It is, moreover, one of the areas where intervention can have the most success in improving the quality of life of older patients. In an attempt to give the widest possible focus to this issue, the Health Sciences Foundation has convened experts from different areas to produce this position paper on Infection in the Elderly, so as to compare the opinions of expert doctors and nurses, pharmacists, journalists, representatives of elderly associations and concluding with the ethical aspects raised by the issue. The format is that of discussion of a series of pre-formulated questions that were discussed by all those present. We begin by discussing the concept of the elderly, the reasons for their predisposition to infection, the most frequent infections and their causes, and the workload and economic burden they place on society. We also considered whether we had the data to estimate the proportion of these infections that could be reduced by specific programmes, including vaccination programmes. In this context, the limited presence of this issue in the media, the position of scientific societies and patient associations on the issue and the ethical aspects raised by all this were discussed. url: https://doi.org/10.37201/req/057.2020 doi: 10.37201/req/057.2020 id: cord-330368-rk31cwl4 author: Bowden, Kasey title: Harnessing the Power of Hospitalists in Operational Disaster Planning: COVID-19 date: 2020-07-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Hospitalists are well poised to serve in key leadership roles and in frontline care in particular when facing a pandemic such as the SARS-CoV-2 (COVID-19) infection. Much of the disaster planning in hospitals around the country addresses overcrowded emergency departments and decompressing these locations; however, in the case of COVID-19, intensive care units, emergency departments, and medical wards ran the risk of being overwhelmed by a large influx of patients needing high-level medical care. In a matter of days, our Division of Hospital Medicine, in partnership with our hospital, health system, and academic institution, was able to modify and deploy existing disaster plans to quickly care for an influx of medically complex patients. We describe a scaled approach to managing hospitalist clinical operations during the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32661930/ doi: 10.1007/s11606-020-05952-6 id: cord-318282-ocgfgx9r author: Boyce, John M title: Meticillin-resistant Staphylococcus aureus date: 2005-10-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S1473309905702437 doi: 10.1016/s1473-3099(05)70243-7 id: cord-276784-8lmg97zc author: Boziki, Marina Kleopatra title: COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated Demyelination date: 2020-06-04 words: 4769.0 sentences: 225.0 pages: flesch: 33.0 cache: ./cache/cord-276784-8lmg97zc.txt txt: ./txt/cord-276784-8lmg97zc.txt summary: Moreover, the management of chronic neurological diseases, such as Multiple Sclerosis (MS), underwent guided modifications, such as an Extended Interval Dose (EID) of Disease-Modifying Treatment (DMT) administration, in order to minimize patients'' exposure to the health system, thus reducing the risk of SARS-CoV-2 infection. In this review, we summarize existing evidence of key immune pathways that the SARS-CoV-2 modifies during COVID-19 and the relevant implication for MS and other autoimmune diseases with associated demyelination (such as Systemic lupus erythematosus and Antiphospholipid syndrome), including the context of potential neuroinvasion by SARS-Cov-2 and the alterations that DMT induces to the immune system. In this respect, the clinical implication of SARS-CoV-2 infection in PwMS needs to be carefully evaluated in long-term prospective studies that assess not only physical disability measurements but also cognition, patient-reported outcomes, and quality of life, thus aiming to elucidate COVID-19-related long-term effects on MS-related neurological status and beyond. abstract: In the frame of the coronavirus disease 2019 (COVID-19) pandemic, recent reports on SARS-CoV-2 potential neuroinvasion placed neurologists on increased alertness in order to assess early neurological manifestations and their potentially prognostic value for the COVID-19 disease. Moreover, the management of chronic neurological diseases, such as Multiple Sclerosis (MS), underwent guided modifications, such as an Extended Interval Dose (EID) of Disease-Modifying Treatment (DMT) administration, in order to minimize patients’ exposure to the health system, thus reducing the risk of SARS-CoV-2 infection. In this review, we summarize existing evidence of key immune pathways that the SARS-CoV-2 modifies during COVID-19 and the relevant implication for MS and other autoimmune diseases with associated demyelination (such as Systemic lupus erythematosus and Antiphospholipid syndrome), including the context of potential neuroinvasion by SARS-Cov-2 and the alterations that DMT induces to the immune system. Moreover we hereby aim to provide an overview of the possible consequences that COVID-19 may carry for the Central Nervous System (CNS) in People with MS (PwMS) and other demyelinating diseases, which are likely to pose challenges for treating Neurologists with respect to the long-term disease management of these diseases. url: https://www.ncbi.nlm.nih.gov/pubmed/32512702/ doi: 10.3390/brainsci10060345 id: cord-302806-1e99cygs author: Bozkurt, Banu title: The COVID-19 Pandemic: Clinical Information for Ophthalmologists date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.4274/tjo.galenos.2020.29805 doi: 10.4274/tjo.galenos.2020.29805 id: cord-048489-ajafw966 author: Bozza, Fernando A title: Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity date: 2008-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Dengue virus pathogenesis is not yet fully understood and the identification of patients at high risk for developing severe disease forms is still a great challenge in dengue patient care. During the present study, we evaluated prospectively the potential of cytokines present in plasma from patients with dengue in stratifying disease severity. METHODS: Seventeen-cytokine multiplex fluorescent microbead immunoassay was used for the simultaneous detection in 59 dengue patients. GLM models using bimodal or Gaussian family were determined in order to associate cytokines with clinical manifestations and laboratory diagnosis. RESULTS: IL-1β, IFN-γ, IL-4, IL-6, IL-13, IL-7 and GM-CSF were significantly increased in patients with severe clinical manifestations (severe dengue) when compared to mild disease forms (mild dengue). In contrast, increased MIP-1β levels were observed in patients with mild dengue. MIP-1β was also associated with CD56+NK cell circulating rates. IL-1β, IL-8, TNF-α and MCP-1 were associated with marked thrombocytopenia. Increased MCP-1 and GM-CSF levels correlated with hypotension. Moreover, MIP-1β and IFN-γ were independently associated with both dengue severity and disease outcome. CONCLUSION: Our data demonstrated that the use of a multiple cytokine assay platform was suitable for identifying distinct cytokine profiles associated with the dengue clinical manifestations and severity. MIP-β is indicated for the first time as a good prognostic marker in contrast to IFN-γ that was associated with disease severity. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474613/ doi: 10.1186/1471-2334-8-86 id: cord-252013-ehyuflg3 author: Bozzani, Antonio title: ACUTE ARTERIAL AND DEEP VENOUS THROMBOEMBOLISM IN COVID-19 PATIENTS date: 2020-09-22 words: 2533.0 sentences: 127.0 pages: flesch: 45.0 cache: ./cache/cord-252013-ehyuflg3.txt txt: ./txt/cord-252013-ehyuflg3.txt summary: AIM: Our aim was to report the experience of the Department of Vascular Surgery of Pavia (Lombardy), including the lessons learned and future perspectives regarding the management of COVID-19 patients who developed severe acute ischemia with impending lower limb loss or deep vein thrombosis (DVT). CONCLUSIONS: Our study confirms that critically ill, COVID-19 patients who develop arterial and deep vein thrombosis are at high risk of mortality, but if treated properly, there is an improvement in overall survival rate, especially in patients of 60 years of age or younger. The aim of our analysis was to report our experience of the Department of Vascular Surgery of Pavia (Lombardy), focusing on the lessons learned and future perspectives regarding the management of COVID-19 patients who developed severe acute ischemia with impending lower limb loss or deep vein thrombosis (DVT). abstract: INTRODUCTION: The Lombardy region (Italy) suffered severe problems during the acute phase of the outbreak of COVID-19 in Italy (March-April 2020) with 16,000 diagnosed COVID-19 related deaths (49% of the total COVID-19 related deaths in Italy). In the area surrounding Pavia during the critical stage of the outbreak (March-April), 1,225 of the documented 4,200 deaths were related to COVID-19 infection, with a mortality rate of 181/100,000 inhabitants and an increase in deaths of 138% compared to the same period in previous years. AIM: Our aim was to report the experience of the Department of Vascular Surgery of Pavia (Lombardy), including the lessons learned and future perspectives regarding the management of COVID-19 patients who developed severe acute ischemia with impending lower limb loss or deep vein thrombosis (DVT). MATERIALS AND METHODS: We carried out a retrospective data collection of COVID-19 patients with severe acute ischemia of the lower limbs or DVT observed in our Department during the period March 1(st) to April 30(th) 2020. Primary outcomes of the analysis were postoperative mortality for all patients and amputation rates only in those COVID-19 patients suffering from acute lower limb ischemia. Secondary outcomes were the prevalence of the disease among admitted COVID-19 patients, and any possible correlation between inflammatory parameters, thrombolytic status, and the presence of acute ischemia or DVT. RESULTS: We observed 38 patients (28 male) with severe COVID-19 infection (6 with lower limb arterial thrombosis and 32 with DVT). The median age was 64 years (range 30-94 years). In the arterial group, 3 had thrombosis on plaque and 3 on healthy arteries ("simple" arterial thrombosis). All underwent operative or hybrid (open/endo) revascularization; 1 patient died from major organ failure (MOF) and one patient underwent major amputation. In the DVT group, 9 (28%) patients died from MOF, despite aggressive medical therapy. In patients with "simple" arterial thrombosis and those with DVT, we observed a decrease in inflammatory parameters (CRP) and in D-dimer and fibrinogen after aggressive therapy (p <0.001). CONCLUSIONS: Our study confirms that critically ill, COVID-19 patients who develop arterial and deep vein thrombosis are at high risk of mortality, but if treated properly, there is an improvement in overall survival rate, especially in patients of 60 years of age or younger. url: https://www.sciencedirect.com/science/article/pii/S0039606020306127?v=s5 doi: 10.1016/j.surg.2020.09.009 id: cord-256888-tdx12ccj author: Bradley, Benjamin T title: Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series date: 2020-07-16 words: 5006.0 sentences: 300.0 pages: flesch: 45.0 cache: ./cache/cord-256888-tdx12ccj.txt txt: ./txt/cord-256888-tdx12ccj.txt summary: To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling. 8 Post-mortem studies have shown pulmonary, renal, and small vessel injury, with particles resembling virus observed in the kidney by electron microscopy. By electron microscopy, aggregates of uniform, round enveloped particles ranging in size from around 70 nm to 100 nm with peripheral spike-like projections consistent with the morphology described for SARS-CoV-2 were observed in the lung, trachea, kidney, and large intestine of patient 8 and patient 13. [9] [10] [11] [12] We present a case series of autopsy findings in 14 patients who died after SARS-CoV-2 infection. The major histopathological observation in our series of patients who died with COVID-19 was diffuse alveolar damage-type lung injury in the acute or organising phases (12 [86%] of 14 patients). abstract: BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic, with increasing deaths worldwide. To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling. We aimed to provide a clinicopathological report of severe COVID-19 cases by documenting histopathological changes and evidence of SARS-CoV-2 tissue tropism. METHODS: In this case series, patients with a positive antemortem or post-mortem SARS-CoV-2 result were considered eligible for enrolment. Post-mortem examinations were done on 14 people who died with COVID-19 at the King County Medical Examiner's Office (Seattle, WA, USA) and Snohomish County Medical Examiner's Office (Everett, WA, USA) in negative-pressure isolation suites during February and March, 2020. Clinical and laboratory data were reviewed. Tissue examination was done by light microscopy, immunohistochemistry, electron microscopy, and quantitative RT-PCR. FINDINGS: The median age of our cohort was 73·5 years (range 42–84; IQR 67·5–77·25). All patients had clinically significant comorbidities, the most common being hypertension, chronic kidney disease, obstructive sleep apnoea, and metabolic disease including diabetes and obesity. The major pulmonary finding was diffuse alveolar damage in the acute or organising phases, with five patients showing focal pulmonary microthrombi. Coronavirus-like particles were detected in the respiratory system, kidney, and gastrointestinal tract. Lymphocytic myocarditis was observed in one patient with viral RNA detected in the tissue. INTERPRETATION: The primary pathology observed in our cohort was diffuse alveolar damage, with virus located in the pneumocytes and tracheal epithelium. Microthrombi, where observed, were scarce and endotheliitis was not identified. Although other non-pulmonary organs showed susceptibility to infection, their contribution to the pathogenesis of SARS-CoV-2 infection requires further examination. FUNDING: None. url: https://doi.org/10.1016/s0140-6736(20)31305-2 doi: 10.1016/s0140-6736(20)31305-2 id: cord-348430-8xk4dt7t author: Bragazzi, Nicola Luigi title: COVID‐19 knowledge prevents biologics discontinuation: Data from an Italian multicenter survey during RED‐ZONE declaration date: 2020-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SARS‐CoV‐2 become pandemics and there is still a dearth of data about its the potentially among dermatological patients under biologics. We aimed to assess health literacy, disease knowledge, treatment dissatisfaction and biologics attitudes toward COVID‐19. We performed a cross‐sectional, questionnaire‐based survey on 98/105 consecutive dermatological patients treated with biologics—51 suffering from plaque psoriasis, 22 from atopic dermatitis, and 25 from hidradenitis suppurativa. An ad hoc, validated questionnaire has 44 items investigating the following domains: knowledge of COVID‐19 related to (a) epidemiology, (b) pathogenesis, (c) clinical symptoms, (d) preventive measures, and (e) attitudes. Patients data and questionnaires were collected. Despite only 8.1% thought that biologics may increase the risk of COVID‐19, 18.4% and 21.4% of the patients were evaluating the possibility to discontinue or modify the dosage of the current biologic therapy, respectively. Globally, male patients (P = .001) with higher scholarity level (P = .005) displayed higher knowledge of COVID‐19. Patients with lower DLQI (P = .006), longer disease duration (P = .051) and lower scholarity (P = .007) have thought to discontinue/modify autonomously their biologic therapy. At the multivariate logistic regression, only the knowledge of epidemiology and preventive measures resulted independent predictors of continuation vs discontinuation and modification vs no modification, respectively. Dermatologists should promote COVID‐19 knowledge to prevent biologics disruption. url: https://www.ncbi.nlm.nih.gov/pubmed/32415727/ doi: 10.1111/dth.13508 id: cord-276405-yfvu83r9 author: Brat, Gabriel A. title: International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium date: 2020-08-19 words: 5729.0 sentences: 285.0 pages: flesch: 46.0 cache: ./cache/cord-276405-yfvu83r9.txt txt: ./txt/cord-276405-yfvu83r9.txt summary: Because EHRs are not themselves agile analytic platforms, we have been successfully building upon the open source and free i2b2 (for Informatics for Integrating Biology and the Bedside) toolkit [10] [11] [12] [13] [14] [15] [16] [17] to manage, compute, and share data extracted from EHRs. In response to COVID-19, we have organized a global community of researchers, most of whom are or have been members of the i2b2 Academic Users Group, to rapidly set up an ad hoc network that can begin to answer some of the clinical and epidemiological questions around COVID-19 through data harmonization, analytics, and visualizations. Laboratory value trajectories Our initial data extraction included 14 laboratory markers of cardiac, renal, hepatic, and immune dysfunction that have been strongly associated with poor outcomes in COVID-19 patients in previous publications. abstract: We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions. url: https://doi.org/10.1038/s41746-020-00308-0 doi: 10.1038/s41746-020-00308-0 id: cord-318873-zwot69s3 author: Braunstein, Eric D. title: Inpatient Cardiac Monitoring Using a Patch‐Based Mobile Cardiac Telemetry System During the COVID‐19 Pandemic date: 2020-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Coronavirus disease 2019 (COVID‐19) is a worldwide pandemic, and cardiovascular complications and arrhythmias in these patients are common. Cardiac monitoring is recommended for at risk patients; however, the availability of telemetry capable hospital beds is limited. We sought to evaluate a patch‐based mobile telemetry system for inpatient cardiac monitoring during the pandemic. METHODS: A prospective cohort study was performed of inpatients hospitalized during the pandemic who had mobile telemetry devices placed; patients were studied up until the time of discharge or death. The primary outcome was a composite of management changes based on data obtained from the system and detection of new arrhythmias. Other clinical outcomes and performance characteristics of the mobile telemetry system were studied. RESULTS: 82 patients underwent mobile telemetry device placement, of which 31 (37.8%) met the primary outcome, which consisted of 24 (29.3%) with new arrhythmias detected and 18 (22.2%) with management changes. 21 patients (25.6%) died during the study, but none from primary arrhythmias. In analyses, age and heart failure were associated with the primary outcome. Monitoring occurred for an average of 5.3 ± 3.4 days, with 432 total patient‐days of monitoring performed; of these, QT‐interval measurements were feasible in 400 (92.6%). CONCLUSIONS: A mobile telemetry system was successfully implemented for inpatient use during the COVID‐19 pandemic and was shown to be useful to inform patient management, detect occult arrhythmias, and monitor the QT‐interval. Patients with advanced age and structural heart disease may be more likely to benefit from this system. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1111/jce.14727 doi: 10.1111/jce.14727 id: cord-325766-hbppklm5 author: Brienza, Nicola title: Acute Kidney Injury in Coronavirus Disease 2019 Infected Patients: A Meta-Analytic Study date: 2020-07-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: In clinical reports on coronavirus disease 2019 (COVID-19), the incidence of acute kidney injury (AKI) is extremely variable, although AKI is described as an independent risk factor for mortality. A meta-analysis was performed to clarify the incidence and the impact of COVID-19-related AKI on mortality. METHODS: All trials reporting the incidence of AKI in COVID-19 patients were searched using MEDLINE, the Cochrane Library, and EMBASE databases (last update April 26, 2020). RESULTS: Ten trials with a sample of 5,166 patients were included. AKI occurred in 947 out of 5,166 (18.3%) patients. AKI incidence was higher in severe cases: 62/305 severe patients developed AKI (20%) versus 27/1,268 nonsevere patients (2%) (p = 0.00001). AKI occurred in 475 out of 915 (52%) deceased patients versus 183 out of 2,678 (7%) survivors (p = 0.00001). Continuous renal replacement therapy was significantly more frequent in severe cases and in dead patients. CONCLUSION: A significant increase in mortality rate was observed in COVID patients who developed AKI, and AKI incidence was also higher in severe cases. Any supportive strategies to protect kidney could represent valuable intervention to reduce mortality in severe COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32615555/ doi: 10.1159/000509274 id: cord-294636-xes8g0x4 author: Brindle, Mary E. title: Approaching Surgical Triage During the COVID-19 Pandemic date: 2020-05-07 words: 2133.0 sentences: 134.0 pages: flesch: 50.0 cache: ./cache/cord-294636-xes8g0x4.txt txt: ./txt/cord-294636-xes8g0x4.txt summary: The harm caused by failure to modify the surgery schedule has been clearly demonstrated in countries like China where ongoing elective operations and nonessential clinic visits contributed to early rates of in-hospital COVID-19 transmission 2 ; and from Italy where resources consumed through elective surgery including personal protective equipment left health care workers vulnerable when the pandemic crested. Although nonoperative care of appendicitis may have a failure rate between 14 and 30%, the majority of patients will get out of hospital without surgery and will not consume the human and material resources that are most needed in COVID-19 management. 9. COVID-19 surgical care pathways and a COVID-19 Operating room will need to be maintained after the peak of the pandemic has passed as patients with COVID-19 will continue to present with conditions requiring surgery. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32675489/ doi: 10.1097/sla.0000000000003992 id: cord-314280-kf2bo06e author: Brissot, Eolia title: Management of patients with acute leukemia during the COVID-19 outbreak: practical guidelines from the acute leukemia working party of the European Society for Blood and Marrow Transplantation date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1038/s41409-020-0970-x doi: 10.1038/s41409-020-0970-x id: cord-349775-zwslhjju author: Brittain-Long, Robin title: Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial date: 2011-04-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Viral respiratory infections are common worldwide and range from completely benign disease to life-threatening illness. Symptoms can be unspecific, and an etiologic diagnosis is rarely established because of a lack of suitable diagnostic tools. Improper use of antibiotics is common in this setting, which is detrimental in light of the development of bacterial resistance. It has been suggested that the use of diagnostic tests could reduce antibiotic prescription rates. The objective of this study was to evaluate whether access to a multiplex polymerase chain reaction (PCR) assay panel for etiologic diagnosis of acute respiratory tract infections (ARTIs) would have an impact on antibiotic prescription rate in primary care clinical settings. METHODS: Adult patients with symptoms of ARTI were prospectively included. Nasopharyngeal and throat swabs were analysed by using a multiplex real-time PCR method targeting thirteen viruses and two bacteria. Patients were recruited at 12 outpatient units from October 2006 through April 2009, and samples were collected on the day of inclusion (initial visit) and after 10 days (follow-up visit). Patients were randomised in an open-label treatment protocol to receive a rapid or delayed result (on the following day or after eight to twelve days). The primary outcome measure was the antibiotic prescription rate at the initial visit, and the secondary outcome was the total antibiotic prescription rate during the study period. RESULTS: A total sample of 447 patients was randomised. Forty-one were excluded, leaving 406 patients for analysis. In the group of patients randomised for a rapid result, 4.5% (9 of 202) of patients received antibiotics at the initial visit, compared to 12.3% (25 of 204) (P = 0.005) of patients in the delayed result group. At follow-up, there was no significant difference between the groups: 13.9% (28 of 202) in the rapid result group and 17.2% (35 of 204) in the delayed result group (P = 0.359), respectively. CONCLUSIONS: Access to a rapid method for etiologic diagnosis of ARTIs may reduce antibiotic prescription rates at the initial visit in an outpatient setting. To sustain this effect, however, it seems necessary to better define how to follow and manage the patient according to the result of the test, which warrants further investigation. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01133782. url: https://www.ncbi.nlm.nih.gov/pubmed/21521505/ doi: 10.1186/1741-7015-9-44 id: cord-318830-a3n4c5d1 author: Brook, Olga R. title: Feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients date: 2020-09-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To determine the feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients. METHODS: 60 patients who expired between 04/22/2020–05/06/2020 due to COVID-19 were considered for inclusion in the study, based on availability of study staff. Minimally invasive ultrasound-guided autopsy was performed with 14G core biopsies through a 13G coaxial needle. The protocol required 20 cores of the liver, 30 of lung, 12 of spleen, 20 of heart, 20 of kidney, 4 of breast, 4 of testis, 2 of skeletal muscle, and 4 of fat with total of 112 cores per patient. Quality of the samples was evaluated by number, size, histology, immunohistochemistry, and in situ hybridization for COVID-19 and PCR-measured viral loads for SARS-CoV-2. RESULTS: Five (5/60, 8%) patients were included. All approached families gave their consent for the minimally invasive autopsy. All organs for biopsy were successfully targeted with ultrasound guidance obtaining all required samples, apart from 2 patients where renal samples were not obtained due to atrophic kidneys. The number, size, and weight of the tissue cores met expectation of the research group and tissue histology quality was excellent. Pathology findings were concordant with previously reported autopsy findings for COVID-19. Highest SARS-CoV-2 viral load was detected in the lung, liver, and spleen that had small to moderate amount, and low viral load in was detected in the heart in 2/5 (40%). No virus was detected in the kidney (0/3, 0%). CONCLUSIONS: Ultrasound-guided percutaneous post-mortem core biopsies can safely provide adequate tissue. Highest SARS-CoV-2 viral load was seen in the lung, followed by liver and spleen with small amount in the myocardium. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00261-020-02753-7) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32939636/ doi: 10.1007/s00261-020-02753-7 id: cord-344389-aj9q73f0 author: Brosnahan, Shari B. title: COVID-19 Pneumonia Hospitalizations Followed by Re-presentation for Presumed Thrombotic Event date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32589950/ doi: 10.1016/j.chest.2020.06.023 id: cord-337994-pkklt77i author: Brouqui, P. title: Remdesivir investigational trials in COVID-19: a critical reappraisal date: 2020-06-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract During outbreak of emerging disease, the most important aim is to discover an effective drug to save life. Consequently, a lot of effort are generally made by the industry to promote clinical trials with new drugs. Here we review evidence of the 8 most recent reports including 3 randomized controlled trials on the clinical efficacy of remdesivir in treating COVID-19 patient. We conclude that it is far too premature to identify remdesivir as a curative or life-saving intervention. url: https://www.sciencedirect.com/science/article/pii/S2052297520300597?v=s5 doi: 10.1016/j.nmni.2020.100707 id: cord-272135-a09bf50o author: Brouqui, Philippe title: Infection control in the management of highly pathogenic infectious diseases: consensus of the European Network of Infectious Disease date: 2009-04-22 words: 6629.0 sentences: 370.0 pages: flesch: 48.0 cache: ./cache/cord-272135-a09bf50o.txt txt: ./txt/cord-272135-a09bf50o.txt summary: However, because the modes of infectious agent transmission are often underestimated, as was recently reported for infl uenza and SARS, 55 and because tuberculosis cannot be identifi ed without biological testing, EUNID recommends that droplet precaution should be upgraded to airborne precaution each time Situations in which a patient would need to be admitted to an HLIU • Patients with an unknown human-to-human transmittable or a potentially transmittable epidemic febrile illness that is native or imported from abroad • Patients with a known infectious disease caused by a group 3 or 4 agent* At admission of patients with HID to an emergency department • Systematically apply standard precautions and cough and respiratory etiquette • Set up at least one single room with a dedicated route and direct access, or an isolation room as recommended by EUNID for a referral hospital, † if HLIU cannot be used for ruling out HID diagnoses • Off er special training to the emergency department team • Retain close relationships with the HLIU team of the referral hospital abstract: The European Network for Infectious Diseases (EUNID) is a network of clinicians, public health epidemiologists, microbiologists, infection control, and critical-care doctors from the European member states, who are experienced in the management of patients with highly infectious diseases. We aim to develop a consensus recommendation for infection control during clinical management and invasive procedures in such patients. After an extensive literature review, draft recommendations were amended jointly by 27 partners from 15 European countries. Recommendations include repetitive training of staff to ascertain infection control, systematic use of cough and respiratory etiquette at admission to the emergency department, fluid sampling in the isolation room, and analyses in biosafety level 3/4 laboratories, and preference for point-of-care bedside laboratory tests. Children should be cared for by paediatricians and intensive-care patients should be cared for by critical-care doctors in high-level isolation units (HLIU). Invasive procedures should be avoided if unnecessary or done in the HLIU, as should chest radiography, ultrasonography, and renal dialysis. Procedures that require transport of patients out of the HLIU should be done during designated sessions or hours in secure transport. Picture archiving and communication systems should be used. Post-mortem examination should be avoided; biopsy or blood collection is preferred. url: https://www.ncbi.nlm.nih.gov/pubmed/19393960/ doi: 10.1016/s1473-3099(09)70070-2 id: cord-335680-wsczl68g author: Brown, Charles A. title: Myocarditis and idiopathic dilated cardiomyopathy date: 1995-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Idiopathic dilated cardiomyopathy (IDC) accounts for 25% of cases of heart failure in the United States. Understanding the relationship between an inciting event or agent and the development of IDC has progressed only recently. Once IDC has developed, treatment is palliative and little can be done to alter the natural course of the disease. Active myocarditis, a suspected precursor of IDC, is myocardial inflammation and injury without ischemia. The disease ranges from a self-limited flulike illness to one of serious consequence with arrhythmias, heart failure, or death. Many agents have been associated with myocarditis, and the clinical manifestations depend on an interplay between the inciting agent and the host response. The development of a murine model and the expanded use of endomyocardial biopsy using the Dallas criteria have increased our understanding of myocarditis and its sequelae. Therapy consists of managing symptoms using conventional medical regimens for heart failure. Immunosuppressive therapy should be reserved for patients with biopsy-proven disease who have failed conventional therapy. Continued deterioration warrants ventricular assistance and consideration of cardiac transplantation. url: https://www.sciencedirect.com/science/article/pii/S0002934399801648 doi: 10.1016/s0002-9343(99)80164-8 id: cord-030370-89n13hml author: Brown, Colin S. title: Ebola Virus Disease in the Obstetric Population date: 2019-04-11 words: 17486.0 sentences: 770.0 pages: flesch: 47.0 cache: ./cache/cord-030370-89n13hml.txt txt: ./txt/cord-030370-89n13hml.txt summary: Epidemiological factors Considerations for screening for general populations Early: fever, profound weakness or malaise, headache, myalgia, arthralgia, conjunctivitis, nausea or anorexia, throat pain or difficulty swallowing, abdominal or epigastric pain, diarrhea (bloody or nonbloody) Exposure/Contact: infected animals, bushmeat or fruit also fed on by bats, healthcare workers/ traditional healers also treating EVD, items soiled or touched by positive EVD patient, deceased EVD bodies Sexual intercourse with EVD-positive male or EVD survivor Late: confusion and irritability, hiccups, seizures, chest pain, diarrhea (watery or bloody), vomiting (with or without blood), skin rash, internal or external bleeding, shock, respiratory distress Additional considerations for screening obstetric population Vaginal bleeding of unknown origin, spontaneous abortion, premature labor and/or rupture of membranes, preterm labor, antepartum and postpartum hemorrhage, intrauterine fetal demise, stillbirth, loss of consciousness Exposure to products of conception or deceased fetus of EVD positive patient Being a pregnant woman with history of contact with confirmed EVD patient, recent EVD survivor with an intact pregnancy, newborn of an EVD positive mother, infant breastfed by a recent EVD positive mother WHO Library Cataloguing-in-Publication Data [55] setting, women were often left untreated or were provided minimal intervention by frightened medical staff working in an overwhelmed, under resourced health care system in crisis. abstract: The clinical management of Ebola created a significant challenge during the outbreak in West Africa, due to the paucity of previous research conducted into the optimum treatment regimen. That left many centres, to some extent, having to ‘work out’ best practice as they went along, and attempting to conduct real time prospective research. Médecins Sans Frontières (MSF) [1] were the only organization to have provided relatively in depth practical guidance prior to the outbreak and this manual was the basis of further planning between the WHO, national Ministry of Health and Sanitation in Sierra Leone, and other relevant stakeholders. Additionally, guidance changed over the epidemic as experience grew. This chapter will describe four key areas in the management of Ebola in West Africa. Firstly, it outlines the most recent WHO guidance; secondly, it looks back at how Ebola was managed in differing low and high resource settings; thirdly it outlines possible and optimal options for managing complications, paying particular attention to some of the controversies faced; fourthly it describes recent and ongoing studies into potential novel therapies that may shape future practice. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418530/ doi: 10.1007/978-3-319-94854-6_4 id: cord-319823-sp5wibeh author: Brown, Sherry-Ann title: Innovation in Precision Cardio-Oncology During the Coronavirus Pandemic and Into a Post-pandemic World date: 2020-08-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32923460/ doi: 10.3389/fcvm.2020.00145 id: cord-302413-7a80jff2 author: Brown, Timothy S. title: The Effect of The COVID-19 Pandemic On Electively Scheduled HIP and KNEE Arthroplasty Patients in THE United States date: 2020-04-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In response to the COVID-19 pandemic, US hospitals stopped performing elective procedures. This led to cancellation of a large number of hip and knee arthroplasty cases. We aimed to assess the effect this had on our elective primary arthroplasty patients by distributing a specifically designed survey to patients across six institutions identified through the AAHKS Research Committee. Surveys were completed by 360 patients over the course of one week. Patients were most anxious about the uncertainty of when their operation could be rescheduled. Although 85% of patients understood and agreed with the cancellation of elective surgeries as part of public health measures to curb the spread of pandemic, almost 90% of patients plan to reschedule as soon as possible. Financial concerns were minimal in this cohort. Patients suffering from pain of hip and knee arthritis continue to struggle with their end-stage disease and despite anxiety about the COVID-19 pandemic, plan to undergo arthroplasty as soon as possible. url: https://api.elsevier.com/content/article/pii/S0883540320304393 doi: 10.1016/j.arth.2020.04.052 id: cord-011188-59hn9wsv author: Bruce, Lori title: A Pot Ignored Boils On: Sustained Calls for Explicit Consent of Intimate Medical Exams date: 2020-03-09 words: 8933.0 sentences: 434.0 pages: flesch: 45.0 cache: ./cache/cord-011188-59hn9wsv.txt txt: ./txt/cord-011188-59hn9wsv.txt summary: This paper refutes the main arguments in favor of the status quo, identifies a series of harms related to continuing the current practice, and proposes an explicit consent policy for intimate exams along with specific changes to medical school curriculum and institutional culture. Recent surveys and reports reveal that some physicians and medical students still conduct unconsented intimate exams (UIEs) on male and female patients. Patients and members of the general public are often shocked to learn that physicians and medical students may perform intimate exams on them without explicit consent and believe such exams meet the criteria for battery, malpractice, or sexual assault. Interestingly, Ubel, a physician who examined UIE practices in teaching hospitals in a 2003 survey of 401 medical students, found that completion of the obstetrics/gynecology clerkship is associated with decreased interest in informed consent (Ubel 2003) . abstract: Unconsented intimate exams (UIEs) on men and women are known to occur for training purposes and diagnostic reasons, mostly during gynecological surgeries but also during prostate examinations and abdominal surgeries. UIEs most often occur on anesthetized patients but have also been reported on conscious patients. Over the last 30 years, several parties—both within and external to medicine—have increasingly voiced opposition to these exams. Arguments from medical associations, legal scholars, ethicists, nurses, and some physicians have not compelled meaningful institutional change. Opposition is escalating in the form of legislative bans and whistleblower reports. Aspiring to professional and scientific detachment, institutional consent policies make no distinction between intimate exams and exams on any other body part, but patients do not think of their intimate regions in a detached or neutral way and believe intimate exams call for special protections. UIEs are found to contribute to moral erosion and moral distress of medical students and compromise the sacred trust between the medical community and the general public. This paper refutes the main arguments in favor of the status quo, identifies a series of harms related to continuing the current practice, and proposes an explicit consent policy for intimate exams along with specific changes to medical school curriculum and institutional culture. Because patients are the rights-holders of their bodies, consent practices should reflect and uphold patient values which call for explicit consent for intimate exams. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223770/ doi: 10.1007/s10730-020-09399-4 id: cord-011297-4um9w2dx author: Brunker, Lucille title: New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report date: 2019-11-28 words: 2954.0 sentences: 147.0 pages: flesch: 38.0 cache: ./cache/cord-011297-4um9w2dx.txt txt: ./txt/cord-011297-4um9w2dx.txt summary: Despite treatment with multiple anti-epileptic drugs in addition to IV anesthetics, burst suppression was initially unsustainable and the patient remained in super-refractory status epilepticus. Clinical response with a goal of 1–2 bursts per screen on EEG monitor was eventually achieved after a course of rituximab and plasma exchange therapy as well as a 7-day barbiturate coma with a regimen of clobazam, lacosamide, Keppra, and oxcarbazepine followed by a slow taper of phenobarbital and the addition of fosphenytoin. We discuss treatment strategies for new-onset refractory status epilepticus and highlight the role of rapid initiation of burst suppression with high-dose IV anesthetics to ensure neuroprotection while the underlying etiology is addressed with immune-modulating therapy. A midazolam infusion was initiated and up-titrated to 60 mg h −1 but failed to achieve burst suppression, and the patient continued to have generalized epileptic discharges on EEG. abstract: Management of new-onset refractory status epilepticus and the approach to burst suppression variable is often challenging. We present the unusual case of a previously healthy 18-year-old male with new-onset status epilepticus admitted to the neurologic intensive care unit for 70 days. Despite treatment with multiple anti-epileptic drugs in addition to IV anesthetics, burst suppression was initially unsustainable and the patient remained in super-refractory status epilepticus. Extensive evaluation revealed an underlying autoimmune-mediated etiology with positivity for glutamic acid decarboxylase-65 antibody. Clinical response with a goal of 1–2 bursts per screen on EEG monitor was eventually achieved after a course of rituximab and plasma exchange therapy as well as a 7-day barbiturate coma with a regimen of clobazam, lacosamide, Keppra, and oxcarbazepine followed by a slow taper of phenobarbital and the addition of fosphenytoin. Remarkably, the patient was subsequently discharged to a rehabilitation facility with complete neurologic recovery. We discuss treatment strategies for new-onset refractory status epilepticus and highlight the role of rapid initiation of burst suppression with high-dose IV anesthetics to ensure neuroprotection while the underlying etiology is addressed with immune-modulating therapy. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223986/ doi: 10.1007/s42399-019-00185-z id: cord-316029-z708c3ex author: Brunsdon, Priya title: Clinical Pharmacology Considerations for Developing Small‐Molecule Treatments for COVID‐19 date: 2020-07-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Numerous drugs are being investigated for the treatment of COVID‐19, including antivirals and therapies targeting complications related to COVID‐19. The clinical presentation of COVID‐19 varies from mild fever, cough, and dyspnea in the early stages of disease to severe complications such as acute respiratory distress syndrome, systemic hyperinflammation, and sepsis. A thorough understanding of the disease pathogenesis and the disease complications is essential to developing effective therapies to treat this potentially life‐threatening disease. This review offers key clinical pharmacology considerations involved in the development of small molecules for the treatment of COVID‐19. They are based on the major observed disease complications that impact drug absorption, distribution, metabolism, and elimination. We also address considerations regarding potential drug interactions, alternative routes and methods of administration, and dosing in patients on hemodialysis. url: https://www.ncbi.nlm.nih.gov/pubmed/32579707/ doi: 10.1002/jcph.1697 id: cord-352846-p7hhv297 author: Bryson, Ethan O. title: A strategy for management of ECT patients during the COVID-19 pandemic date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32404699/ doi: 10.1097/yct.0000000000000702 id: cord-302316-raf5rlkq author: Brüssow, Harald title: COVID‐19: From pathogenesis models to the first drug trials date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The number of people infected with SARS‐CoV‐2, and sadly dying from COVID‐19, has exploded, and so the amount of literature on the novel coronavirus and the disease it causes has increased proportionately. The case numbers in some countries are beyond the epidemic peak, but the uncertainty about a second wave keeps politicians and societies under pressure. Appropriate decision‐making and winning support from the population depends on precise scientific information rather than leaving the field to scaremongers of all proveniences. This mini‐review is an update of earlier reports (Brüssow, Microb Biotechnol 2020a;13:607; Brüssow, Microb Biotechnol 2020b; https://doi.org/10.1111/1751-7915.13592). url: https://doi.org/10.1111/1751-7915.13611 doi: 10.1111/1751-7915.13611 id: cord-341627-21m8rdhy author: Buda, Natalia title: Lung ultrasound in the diagnosis of COVID-19 infection - A case series and review of the literature date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and spreading worldwide has become a serious challenge for the entire health care system as regards infection prevention, rapid diagnosis, and treatment. Lung ultrasound (LUS) is a dynamically developing diagnostic method used in intensive care, cardiology and nephrology, it can also be helpful in diagnosing and monitoring pneumonia. Interstitial pneumonia appears to be the most common clinical manifestation of coronavirus infection. We present 4 case reports of COVID-19 involving the lungs, in which transthoracic lung ultrasound was successfully utilized as a constituent of bedside diagnostics and a review of the literature concerning potential use of LUS in COVID-19 diagnostics. The possibility to perform this examination repeatedly, its non-invasiveness and high sensitivity make it an important element of care provided for patients with viral pneumonia. url: https://doi.org/10.1016/j.advms.2020.06.005 doi: 10.1016/j.advms.2020.06.005 id: cord-294294-66udu5y4 author: Bullock, Travis S. title: Outpatient surgery in patients with ankle fractures minimises hospital admissions and utilisation of healthcare resources date: 2020-08-08 words: 3192.0 sentences: 170.0 pages: flesch: 41.0 cache: ./cache/cord-294294-66udu5y4.txt txt: ./txt/cord-294294-66udu5y4.txt summary: CONCLUSION: Strategic outpatient management of acute closed ankle fractures is associated with acceptable rates of unplanned emergency department visits, hospital readmissions, and SSIs. In the context of the recent SARS-CoV-2 outbreak, outpatient management of these injuries may aide in the mitigation of nosocomial infections and the preservation of finite healthcare resources. Our study data shows that outpatient surgical fixation represents a reasonable approach to these injuries, as we demonstrated acceptable rates of unplanned ED visits, hospital readmissions, and SSIs. Based on these findings, we suggest that a safe and properly implemented outpatient protocol may be beneficial in mitigating the risk of inpatient viral transmission, safeguarding frontline healthcare workers, and conserving finite resources. In this context, we would also like to emphasise the potential benefit of outpatient surgery for controlling nosocomial infections as it has been suggested that longer pre-operative admissions for surgical fixation of ankle fractures may increase rates, thereby increasing downstream resource utilisation and hospital staffing demands [5, 27] . abstract: PURPOSE: The recent outbreak of the novel coronavirus (SARS-CoV-2) has emphasised the need to minimise hospital admissions and utilisation of healthcare resources. The purpose of this study was to examine the outcomes of an outpatient surgery protocol for acute closed ankle fractures. METHODS: In this retrospective study, 262 patients underwent outpatient surgery for their closed ankle fractures at our level-1 trauma centre. A total of 196 patients met our inclusion criteria and were ultimately included in the final analysis. Our primary outcomes’ measures included post-operative admission to the emergency department within 30 days after surgery and unplanned hospital readmission within 30 days after surgery. Our secondary outcome measure included the incidence of surgical site infection (SSI) within 12 weeks after surgery. RESULTS: Thirty-two patients (16.3%) had an unplanned emergency department visit within 30 days of fracture fixation and two patients (1.0%) required hospital readmission within 30 days of their surgery. Sixteen patients (8.2%) developed SSI, which included 11 (5.6%) superficial and five (2.6%) deep infections. CONCLUSION: Strategic outpatient management of acute closed ankle fractures is associated with acceptable rates of unplanned emergency department visits, hospital readmissions, and SSIs. In the context of the recent SARS-CoV-2 outbreak, outpatient management of these injuries may aide in the mitigation of nosocomial infections and the preservation of finite healthcare resources. url: https://www.ncbi.nlm.nih.gov/pubmed/32770348/ doi: 10.1007/s00264-020-04768-7 id: cord-348578-chfb4i15 author: Bulman, Julie C. title: Transitioning the IR Clinic to Telehealth: A Single-Center Experience during the COVID-19 Pandemic date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Telehealth has not previously been widely implemented as a result of regulatory and reimbursement concerns; however, in the current national emergency of the COVID-19 pandemic, the Centers for Medicare and Medicaid Services has relaxed many of its rules, allowing increased adoption of telehealth services, improving the safety and access of outpatient health care. A complete understanding of the regulatory requirements, technologic options, and billing processes of telehealth is required to initiate a successful clinic. A model is presented here based on a single institution’s experience with implementing telehealth in the outpatient interventional radiology clinic. url: https://api.elsevier.com/content/article/pii/S1051044320304516 doi: 10.1016/j.jvir.2020.05.008 id: cord-348570-plds5kbn author: Buneviciene, Inesa title: Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis date: 2020-10-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: mHealth can be used to deliver interventions to optimize Health-related quality of life (HRQoL) of cancer patients. In this systematic-review and meta-analysis, we explored the possible impact of health interventions delivered via mHealth tools on HRQoL of cancer patients. The systematic literature search was performed on July 20, 2019, to identify studies that evaluated the impact of mHealth intervention on HRQoL of cancer patients. We identified 25 studies (17 randomized controlled trials and 8 pre-post design studies; 957 patients) that evaluated mHealth interventions. The most commonly studied mHealth interventions included physical activity/ fitness interventions (9 studies), cognitive behavioral therapy (6 studies), mindfulness/ stress management (3 studies). In the majority of studies, mHealth interventions were associated with an improved HRQoL of cancer patients. The meta-analysis of the identified studies supported the positive effect of mHealth interventions for HRQoL of cancer patients. mHealth interventions are promising for improving HRQoL of cancer patients. url: https://api.elsevier.com/content/article/pii/S1040842820302596 doi: 10.1016/j.critrevonc.2020.103123 id: cord-275214-mqvw0219 author: Burlacu, Alexandru title: Is Thrombophilic Genetic Profile Responsible for an Acute Ischemic Stroke in a COVID-19 Male Patient? date: 2020-10-15 words: 1019.0 sentences: 70.0 pages: flesch: 39.0 cache: ./cache/cord-275214-mqvw0219.txt txt: ./txt/cord-275214-mqvw0219.txt summary: title: Is Thrombophilic Genetic Profile Responsible for an Acute Ischemic Stroke in a COVID-19 Male Patient? presented a recent study (published in August 2020 in the Clinical and Applied Thrombosis/Hemostasis), a comprehensive review of the COVID-19 induced coagulopathy with its particular traits, the specificity of thromboembolic events and potential therapeutic interventions. In this particular context, the authors underline that the conventional clinical assessment of the risk of thrombotic events may not be efficient due to disease''s particular evolution. Three days before the neurological event, the patient presented with mild respiratory symptoms erroneously interpreted as a non-COVID-19 pulmonary infection. We strongly suspect that subtle genetic risk factors for thrombotic events may influence the COVID-19 course, might hold the key to understanding the significant heterogeneity of COVID-19 manifestations, and may prove useful in assessing the COVID-19 patients'' risk for thrombosis and severe disease. Unpuzzling COVID-19 prothrombotic state: are preexisting thrombophilic risk profiles responsible for heterogenous thrombotic events? abstract: nan url: https://doi.org/10.1177/1076029620967107 doi: 10.1177/1076029620967107 id: cord-335078-z7k59k8o author: Burton-Papp, Helmi C. title: Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre date: 2020-07-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Critically ill patients admitted to hospital following SARS-CoV-2 infection often experience hypoxic respiratory failure and a proportion require invasive mechanical ventilation to maintain adequate oxygenation. The combination of prone positioning and non-invasive ventilation in conscious patients may have a role in improving oxygenation. The purpose of this study was to assess the effect of prone positioning in spontaneously ventilating patients receiving non-invasive ventilation admitted to the intensive care. Clinical data of 81 patients admitted with COVID 19 pneumonia and acute hypoxic respiratory failure were retrieved from electronic medical records and examined. Patients who had received prone positioning in combination with non-invasive ventilation were identified. A total of 20 patients received prone positioning in conjunction with non-invasive ventilation. This resulted in improved oxygenation as measured by a change in PaO (2)/FiO (2) (P/F) ratio of 28.7 mmHg while prone, without significant change in heart rate or respiratory rate. Patients on average underwent 5 cycles with a median duration of 3 hours. There were no reported deaths, 7 of the 20 patients (35%) failed non-invasive ventilation and subsequently required intubation and mechanical ventilation. In our cohort of 20 COVID-19 patients with moderate acute hypoxic respiratory failure, prone positioning with non-invasive ventilation resulted in improved oxygenation. Prone positioning with non-invasive ventilation may be considered as an early therapeutic intervention in COVID-19 patients with moderate acute hypoxic respiratory failure. url: https://www.ncbi.nlm.nih.gov/pubmed/33110499/ doi: 10.12688/f1000research.25384.1 id: cord-323133-gdg50omp author: Buzatto, G. P. title: The pathogens profile in children with otitis media with effusion and adenoid hypertrophy date: 2017-02-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To evaluate the presence of viruses and bacteria in middle ear and adenoids of patients with and without otitis media with effusion (OME). METHODS: Adenoid samples and middle ear washes (MEW) were obtained from children with OME associated with adenoid hypertrophy undergoing adenoidectomy and tympanostomy, and compared to those obtained from patients undergoing cochlear implant surgery, as a control group. Specific DNA or RNA of 9 respiratory viruses (rhinovirus, influenza virus, picornavirus, syncytial respiratory virus, metapneumovirus, coronavirus, enterovirus, adenovirus and bocavirus) and 5 bacteria (S. pneumoniae, H. influenzae, M. catarrhalis, P. aeruginosa and S. aureus) were extracted and quantified by real-time PCR. RESULTS: 37 OME and 14 cochlear implant children were included in the study. At the adenoid, virus and bacteria were similarly detected in both OME and control patients. At the middle ear washes, however, a higher prevalence of bacteria was observed in patients with OME (p = 0.01). S. pneumoniae (p = 0.01) and M. catarrhalis (p = 0.022) were the bacteria responsible for this difference. Although total virus detection was not statistically different from controls at the middle ear washes (p = 0.065), adenovirus was detected in higher proportions in adenoid samples of OME patients than controls (p = 0.019). CONCLUSIONS: Despite both OME and control patients presented similar rates of viruses and bacteria at the adenoid, children with OME presented higher prevalence of S. pneumonia, M. catarrhalis in middle ear and adenovirus in adenoids when compared to controls. These findings could suggest that these pathogens could contribute to the fluid persistence in the middle ear. url: https://doi.org/10.1371/journal.pone.0171049 doi: 10.1371/journal.pone.0171049 id: cord-323787-9lq8rkih author: Bösch, Florian title: Attenuated early inflammatory response in solid organ recipients with COVID‐19 date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Immunosuppression leaves transplanted patients at particular risk for severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection. The specific features of coronavirus disease 2019 (COVID‐19) in immunosuppressed patients are largely unknown and therapeutic experience is lacking. Seven transplanted patients (two liver, three kidneys, one double lung, one heart) admitted to the Ludwig‐Maximilians‐University Munich because of COVID‐19 and tested positive for SARS‐CoV‐2 were included. The clinical course and the clinical findings were extracted from the medical record. The two liver transplant patients and the heart transplant patient had an uncomplicated course and were discharged after 14, 18 and 12 days, respectively. Two kidney transplant recipients were intubated within 48 hours. One kidney and the lung transplant recipients were required to intubate after ten and 15 days, respectively. Immunosuppression was adapted in five patients, but continued in all patients. Compared to non‐transplanted patients at the ICU (n=19) the inflammatory response was attenuated in transplanted patients, which was proven by decreased IL‐6 blood values. This analysis might provide evidence that continuous immunosuppression is safe and probably beneficial since there was no hyperinflammation evident. Although transplanted patients might be more susceptible to an infection with SARS‐CoV‐2, their clinical course seems to be similar to immunocompetent patients. url: https://doi.org/10.1111/ctr.14027 doi: 10.1111/ctr.14027 id: cord-258576-ywbyflas author: Bösmüller, Hans title: The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The pandemia of coronavirus disease 2019 (COVID-19) has caused more than 355,000 confirmed deaths worldwide. However, publications on postmortem findings are scarce. We present the pulmonary findings in four cases of fatal COVID-19 with a spectrum of lung pathology reflecting disease course and duration, invasive therapies, and laboratory features. Early disease is characterized by neutrophilic, exudative capillaritis with microthrombosis and high levels of IL-1beta and IL-6. Later stages are associated with diffuse alveolar damage and ongoing intravascular thrombosis in small to medium-sized pulmonary vessels, occasionally with areas of infarction equivalents, accompanied by laboratory features of disseminated intravascular coagulation. In late stages, organizing pneumonia with extensive intra-alveolar proliferation of fibroblasts and marked metaplasia of alveolar epithelium can be observed. Viral RNA is encountered in the lung, with virus particles in endothelial cells and pneumocytes. In many patients, multi-organ failure with severe liver damage sets in finally, possibly as consequence of an early-onset pro-inflammatory cytokine storm and/or thrombotic microangiopathy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00428-020-02881-x) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s00428-020-02881-x doi: 10.1007/s00428-020-02881-x id: cord-279299-5djtiomq author: CAO, HUI-FANG title: A confirmed severe case of human infection with avian-origin influenza H7N9: A case report date: 2014-12-30 words: 2563.0 sentences: 127.0 pages: flesch: 45.0 cache: ./cache/cord-279299-5djtiomq.txt txt: ./txt/cord-279299-5djtiomq.txt summary: The day after admission to the Jingnan District Centre Hospital of Shanghai (Shanghai, China), the patient was diagnosed with severe H7N9 avian influenza infection by nasopharyngeal swab and blood sampling detection. In the present study, the patient exhibited a rapid deterioration; however, a diagnosis of H7N9 avian influenza was only confirmed after five days of continuous fever. Considering the initial diagnosis of severe pneumonia complicated with type I respiratory failure, the patient was administered oxygen therapy and methylprednisolone to reduce the systemic inflammatory response, and biapenem (0.6 g twice daily, i.v) and azithromycin (0.5 g/day, i.v) were applied as anti-infective agents. Combining the epidemiological history and the rapid progression in the pulmonary lesions of the patient (Fig. 3) , a diagnosis of human infection with H7N9 avian influenza was considered. abstract: A male patient, aged 77 years, was admitted to hospital with the chief complaint of persistent hyperpyrexia that had presented for four days. The patient also suffered from hypoxemia, and a large white shadow in the left lung was observed on a chest radiograph, indicating inflammation. No therapeutic effect was observed with anti-infection treatment. The patient admitted a history of direct contact with live chickens two weeks prior to hospital admission. The day after admission to the Jingnan District Centre Hospital of Shanghai (Shanghai, China), the patient was diagnosed with severe H7N9 avian influenza infection by nasopharyngeal swab and blood sampling detection. Although the patient received anti-infective drugs, intubated assisted ventilation and circulation support, the condition of the patient continued to rapidly deteriorate. Oxygen saturation decreased and gastrointestinal bleeding occurred, with the body temperature fluctuating between 39 and 40°C. By day 6 after admission, the patient presented with circulatory failure, with liver and renal failure. On day 7, the blood pressure of the patient was unable to be measured, and the patient was diagnosed with multiple organ dysfunction. Subsequently, clinical death was declared with the patient exhibiting asystole and no spontaneous breathing. url: https://www.ncbi.nlm.nih.gov/pubmed/25667615/ doi: 10.3892/etm.2014.2159 id: cord-339333-7tpnbr8q author: CHEN, YUXIAN title: Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults date: 2014-11-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Steroid-induced osteonecrosis of the femoral head (SONFH) is a disabling, aseptic and ischemic disease that develops following steroid therapy. The pathogenesis of SONFH is unclear, so the early diagnosis and treatment for this disease is yet to be established. The purpose of the present study was to identify potential biomarkers for SONFH. The differential expression of serum proteins from patients with SONFH and healthy volunteers was analyzed by the proteomics method. The protein samples were labeled and subjected to isoelectric focusing and two-dimensional gel electrophoresis. The resultant protein spots were matched and quantified by an imaging analysis system. The differentially-expressed protein spots were subjected to in-gel trypsin digestion followed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Significantly lower levels of complement component 3 (C3), C4, inter-α-trypsin inhibitor heavy chain H4 and α-2-macroglobulin were found in the serum of patients with SONFH. These proteins are reported to be actively involved in intravascular coagulation, apoptosis and reactive oxygen species imbalance, indicating that multiple pathological reactions occur in SONFH and these proteins may serve as potential biomarkers for the diagnosis of SONFH. url: https://www.ncbi.nlm.nih.gov/pubmed/25452779/ doi: 10.3892/etm.2014.2069 id: cord-326984-o27rp468 author: CHIEN, Jung‐Yien title: Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome date: 2006-10-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective and background: Pathological changes in severe acute respiratory syndrome (SARS) suggest that SARS sequelae are associated with dysregulation of cytokine and chemokine production. To improve understanding of the immuno‐pathological processes involved in lung injury associated with SARS, the temporal changes in cytokine/chemokine profiles in the sera of SARS patients were compared with those of patients with community‐acquired pneumonia (CAP), according to the degree of lung involvement. Methods: Serum levels of 11 cytokines and chemokines, in 14 patients with SARS and 24 patients with CAP, were serially checked using a bead‐based multiassay system. Sera from 12 healthy subjects were used as normal controls. Results: The serum levels of interferon‐γ‐inducible protein‐10 (IP‐10), IL‐2 and IL‐6 were significantly elevated during SARS infection. In patients with CAP, but not in those with SARS, the levels of interferon‐γ, IL‐10, IL‐8 and monokine induced by interferon‐γ (MIG) were significantly elevated compared with the levels in healthy controls. Among the chemokines/cytokines, IL‐6 levels correlated most strongly with radiographic scores (r = 0.62). The elevation of IP‐10 and IL‐2 antedated the development of chest involvement and reached peak levels earlier than the radiographic scores. In contrast, the dynamic changes in IL‐6, C‐reactive protein and neutrophils occurred synchronously with the changes in radiographic scores. The mean ratio of IL‐6 to IL‐10 in SARS patients (4.84; range 0.41–21) was significantly higher than that in CAP patients (2.95; range 0.02–10.57) (P = 0.04). Conclusions: The early induction of IP‐10 and IL‐2, as well as the subsequent over‐production of IL‐6 and lack of IL‐10 production, probably contribute to the main immuno‐pathological processes involved in lung injury in SARS. These changes in cytokine/chemokine profile are remarkably different from those observed in CAP patients. url: https://www.ncbi.nlm.nih.gov/pubmed/17052299/ doi: 10.1111/j.1440-1843.2006.00942.x id: cord-315149-71bmj5il author: Caballero Bermejo, Antonio F. title: Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: In some patients, acute, life-threatening respiratory injury produced by viruses such as SARS-CoV and other viral pneumonia are associated with an over-exuberant cytokine release. Elevated levels of blood IL-6 had been identified as a one of the risk factors associated with severe COVID-19 disease. Anti-IL6 inhibitors are among the therapeutic armamentarium for preventing the fatal consequences of acute respiratory and multi organ failure in around 20% of the COVID-19 infected patients. At present, their use is prioritized to patients with severe interstitial pneumonia (Brescia-COVID Scale-COVID 2-3) with hyperinflammation as determined by the presence of elevated IL6 and/or d-dimer, or progressive d-dimer increase, in patients who otherwise are subsidiary to ICU admission. However, many uncertainties remain on the actual role of anti-IL6 inhibitors in this setting, and whether current use and timing is the right one. There is the hypothesis that the use of anti-IL6 inhibitors at an earlier state during the hyperinflammatory syndrome would be beneficial and may avoid progressing to ARDS. On the other hand, the standard of care has changed and nowadays the use of corticosteroids has become part of the SOC in the treatment of COVID-19 pneumonia. Our limited experience suggests that better treatment outcomes can be achieved when combining IL6-inhibitors (e.g. sarilumab) with corticosteroids. The aim of the present study is to evaluate if an earlier therapeutic intervention with sarilumab plus SOC (including corticosteroids) may be more effective than current standard of care alone, in preventing progression to respiratory failure in COVID-19 infected patients with interstitial pneumonia. This study will also provide supportive evidence to that provided by currently ongoing studies on the efficacy and safety of sarilumab in this clinical context. TRIAL DESIGN: A phase two multi-center randomised controlled trial (RCT) with two parallel arms (1:1 ratio). PARTICIPANTS: They will be hospitalized patients, of at least 18 years of age, with severe COVID-19 who have positive RT-PCR test and have radiographic evidence of pulmonary infiltrates by imaging or rales/crackles on exam and SpO2 ≤ 94% on room air that requires supplemental oxygen. Patients must present elevation of inflammatory parameters (IL-6 > 40 pg/mL or d-dimer >1.0 mcg/ml) or, alternatively, progressive worsening in at least two of these inflammatory parameters in the prior 24-48h: CRP, LDH, serum ferritin, lymphopenia, or d-dimer. Exclusion criteria: high oxygen requirements (including face mask with reservoir, non-invasive mechanical ventilation or high flow nasal cannula, or mechanical ventilation), admission to ICU, pregnancy or lactation, allergy or hypersensitivity to sarilumab or corticoesteroids, immunosuppressive antibody therapy within the past 5 months, AST/ALT values > 10 x ULN, neutropenia (< 0.5 x 109/L), severe thrombocytopenia (< 50 x 109/L), sepsis caused by an alternative pathogen, diverticulitis with risk of perforation or ongoing infectious dermatitis. The study will be conducted in several hospitals in Spain. INTERVENTION AND COMPARATOR: Patients randomised to the experimental arm will receive sarilumab + methylprednisolone plus SOC for COVID-19. Patients included in the control arm will receive methylprednisolone plus SOC for COVID-19. Corticosteroids will be given to all patients at a 1mg/kg/d of methylprednisolone for at least 3 days. Clinical follow-up visits will be performed at 3, 5, and 15 days after treatment randomization. Patients in the control group (SOC group without sarilumab) progressing to Brescia- COVID 2-3 plus inflammatory markers, will be given the option to be rescued with sarilumab at the same doses and, in that case, be included in an open-label phase and be followed up for additional weeks (with visits at 3, 7 and 15 days after sarilumab rescue administration). Patients randomly assigned to sarilumab therapy at baseline progressing to Brescia-COVID 2-3 will be rescued according to local clinical practice protocols. A final follow-up visit will be conducted for all patients at day 29 from randomization, regardless of initial treatment assignment. MAIN OUTCOMES: Primary end point is the proportion of patients progressing to either severe respiratory failure (Brescia-COVID ≥2), ICU admission, or death. RANDOMIZATION: Randomization codes were produced by means of the PROC PLAN of the SAS system, with a 1:1 assignment ratio, stratifying by centre and using blocks multiple of 2 elements. The randomization schedule will be managed through the eCRF in a concealed manner. BLINDING (MASKING): All study drugs will be administered as open label. No blinding methods will be used in this trial. NUMBERS TO BE RANDOMISED (SIMPLE SIZE): The target sample size will be 200 COVID-19 patients, who will be allocated randomly to control arm (100) and treatment arm (100). TRIAL STATUS: Protocol Code: SARTRE Protocol Date: May 05th 2020. Version: 2.0 The study has been approved by the Spanish Competent Authority (AEMPS) as a low intervention clinical trial. Start of recruitment: August, 2020 End of recruitment: May, 2021 TRIAL REGISTRATION: Identifier: EudraCT Number: 2020-002037-15; Registration date: 26 May 2020. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this letter serves as a summary of the key elements of the full protocol. The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). url: https://doi.org/10.1186/s13063-020-04633-3 doi: 10.1186/s13063-020-04633-3 id: cord-315116-u7btx7nt author: Cabrera-Tasayco, Fiorella del Pilar title: Biosafety Measures at the Dental Office After the Appearance of COVID-19: A Systematic Review date: 2020-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The purpose of this research was to determine biosecurity measures at the dental office after the appearance of coronavirus disease 2019 (COVID-19). A search was conducted in the main databases of the scientific literature using the words “COVID-19, coronavirus, SARS-Cov2, biosecurity, disinfection and dentistry.” We analyzed biosecurity and disinfection standards at the dental office and dental health personnel to date, and their adaptation to the needs and way of working of each. As a result, according to the information collected the following procedure was identified: a telephone appointment must be made and a questionnaire should be given before dental care; at arrival to the appointment, the temperature of the patient should be taken and proper cleaning and disinfection of the waiting room should be maintained. Panoramic radiography and CBCT are the auxiliary methods of choice. Absolute isolation and atraumatic restorative therapy techniques are a good alternative to decrease fluid exposure. The removal of protective clothing and accessories must follow a specific order and washing hands before and after is essential. In conclusion, the efficient biosecurity for dentists and patients in all dental care processes before, during, and immediately after the appointment reduces the risk of COVID-19 infection and allows healthy dental care environments. url: https://www.ncbi.nlm.nih.gov/pubmed/32713385/ doi: 10.1017/dmp.2020.269 id: cord-318326-q9fnbg8n author: Cacciapuoti, Sara title: Immunocytometric analysis of COVID patients: A contribution to personalized therapy? date: 2020-08-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: AIMS: This study aims to cast light on immunocytometric alterations in COVID-19, a potentially fatal viral infection with heterogeneous clinical expression and a not completely defined pathophysiology. METHODS: We studied 35 COVID patients at hospital admission testing by cytofluorimetry a large panel of lymphocyte subpopulations and serum tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-17A and the soluble receptor of IL-17A (IL-17RA). KEY FINDINGS: At hospital admission, total lymphocytes and most T and B subpopulations were reduced in 50–80% of patients, with close relationship to disease severity. While activated T helper 1 (TH1) and TH17 cells resulted normal or higher. Serum IL-6 was increased in all patients, while TNF-α and IL-17A were higher in advanced stages. A patient subset with low severity had very high IL-17RA levels. Tocilizumab treatment caused an increase of IL-17A in 3/6 patients and a reduction in 3 others, while the lymphocyte number increased in 3 patients and did not change in the others. SIGNIFICANCE: Cytofluorimetry revealed a functional exhaustion of most lymphocyte populations in COVID patients not involving activated TH1 and TH17. Consequently, there was a relevant cytokines production that contributes to impair the respiratory inflammation. The increase of TH17 and IL-17 in a subset of cases and the evidence of a significant increase of IL-17RA (that prevents the interaction of IL-17 with the cell receptor) in patients with low severity suggest that some patients could benefit from monoclonal antibodies treatment targeting IL-17 pathway. Immunocytofluorimetric markers may contribute to a personalized therapy in COVID patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32871183/ doi: 10.1016/j.lfs.2020.118355 id: cord-323940-ubazgvov author: Cafiero, Concetta title: Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease date: 2020-10-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The latest developments in precision medicine allow the modulation of therapeutic approaches in different pathologies on the basis of the specific molecular characterization of the patient. This review of the literature coupled with in silico analysis was to provide a selected screening of interactions between single-nucleotide polymorphisms (SNPs) and drugs (repurposed, investigational, and biological agents) showing efficacy and toxicityin counteracting Covid-19 infection. In silico analysis of genetic variants related to each drug was performed on such databases as PharmGKB, Ensembl Genome Browser, www.drugs.com, and SNPedia, with an extensive literature review of papers (to May 10, 2020) on Covid-19 treatments using Medline, Embase, International Pharmaceutical Abstracts, PharmGKB, and Google Scholar. The clinical relevance of SNPs, known as both drug targets and markers, considering genetic variations with known drug responses, and the therapeutic consequences are discussed. In the context of clinical treatment of Covid-19, including infection prevention, control measures, and supportive care, this review highlights the importance of a personalized approach in the final selection of therapy, which is probably essential in the management of the Covid-19 pandemic. url: https://doi.org/10.2147/pgpm.s270069 doi: 10.2147/pgpm.s270069 id: cord-291052-nstfe15a author: Cag, Yasemin title: A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort date: 2020-08-27 words: 1930.0 sentences: 125.0 pages: flesch: 54.0 cache: ./cache/cord-291052-nstfe15a.txt txt: ./txt/cord-291052-nstfe15a.txt summary: This manuscript aims to present a treatment algorithm we applied to manage COVID-19 patients admitted to our hospital. We administered hydroxychloroquine plus doxycycline to mild cases (isolated at home) for 3 days and lopinavir plus doxycycline to moderate and severe cases (hospitalized) for 5 days. Second, moderate to severe cases were hospitalized and prescribed with a regimen of lopinavir plus doxycycline plus ceftriaxone for 5 days. We hospitalized moderate to severe cases and administered lopinavir combined with doxycycline and ceftriaxone to 343 patients, among whom 161 had positive PCR test results (161/343, 46.9%). We administered hydroxychloroquine to mild cases isolated at home, lopinavir plus doxycycline to hospitalized moderate to severe cases, and favipiravir in the salvage treatment. We concluded that home isolation of mild cases is an effective means to manage the burden of disease, while lopinavir plus doxycycline is an alternative to current treatment regimens for COVID-19. abstract: This manuscript aims to present a treatment algorithm we applied to manage COVID-19 patients admitted to our hospital. During the study period, 2043 patients with suspected COVID-19 were admitted to the emergency department. Molecular tests indicated that 475 of these patients tested positive for COVID-19. We administered hydroxychloroquine plus doxycycline to mild cases (isolated at home) for 3 days and lopinavir plus doxycycline to moderate and severe cases (hospitalized) for 5 days. The overall case fatality rate was 4.2% (20/475). url: https://www.ncbi.nlm.nih.gov/pubmed/32856202/ doi: 10.1007/s10096-020-04016-1 id: cord-312632-g4250q6l author: Cai, Xiaofang title: Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: An outbreak of the novel coronavirus disease 2019 (COVID-19) occurred in Wuhan, China, in December 2019, which then rapidly spread to more than 80 countries. However, detailed information on the characteristics of COVID-19 in children is still scarce. Five patients with non-respiratory symptoms as the first manifestation were hospitalized from the emergency department, and were later confirmed to have COVID-19, between 23 January and 20 February 2020, at the Wuhan Children's Hospital. SARS-CoV-2 nucleic acid detection was positive for all the patients. Four of the patients were male and one was female, and their ages ranged from 2-months to 5.6 years. All lived in Wuhan. One patient had a clear history of exposure to SARS-CoV-2, one had a suspected history of exposure, while the others had no exposure history. For three of the five patients, the primary onset disease required an emergency operation or treatment, and included intussusception, acute suppurative appendicitis perforation with local peritonitis, and traumatic subdural hemorrhage with convulsion, while for the other two it was acute gastroenteritis (including one patient with hydronephrosis and a stone in his left kidney). During the course of the disease, four of the five patients had a fever, whereas one case had no fever or cough. Two patients had leukopenia, and one also had lymphopenia. In the two cases of severe COVID-19, the levels of CRP, PCT, serum ferritin, IL-6, and IL-10 were significantly increased, whereas the numbers of CD3+, CD4+, CD8+ T lymphocytes, and CD16 + CD56 natural killer cells were decreased. We also found impaired liver, kidney, and myocardial functions; the presence of hypoproteinemia, hyponatremia, and hypocalcemia; and, in one case, abnormal coagulation function. Except for one patient who had a rotavirus infection, all patients tested negative for common pathogens, including the influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, enterovirus, mycoplasma, Chlamydia, and Legionella. Chest CT images of all the patients showed patches or ground-glass opacities in the lung periphery or near the pleura, even large consolidations. This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children. url: https://doi.org/10.3389/fped.2020.00258 doi: 10.3389/fped.2020.00258 id: cord-303517-8971aq02 author: Cajamarca-Baron, Jairo title: SARS-CoV-2 (COVID-19) in Patients with some Degree of Immunosuppression date: 2020-10-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background It is not clear whether patients with some degree of immunosuppression have worse outcomes in SARS-CoV-2 infection, compared to healthy people. Objective To carry out a narrative review of the information available on infection by SARS-CoV-2 in immunosuppressed patients, especially patients with cancer, transplanted, neurological diseases, primary and secondary immunodeficiencies. Results Patients with cancer and recent cancer treatment (chemotherapy or surgery) and SARS-CoV-2 infection have a higher risk of worse outcomes. In transplant patients (renal, cardiac and hepatic), with neurological pathologies (multiple sclerosis (MS), neuromyelitis optica (NMODS), myasthenia gravis (MG)), primary immunodeficiencies and infection with human immunodeficiency virus (HIV) in association with immunosuppressants, studies have shown no tendency for worse outcomes. Conclusion Given the little evidence we have so far, the behaviour of SARS-CoV-2 infection in immunosuppressed patients is unclear, but current studies have not shown worse outcomes, except for patients with cancer. url: https://api.elsevier.com/content/article/pii/S2173574320301295 doi: 10.1016/j.reumae.2020.08.001 id: cord-006518-al94gxjw author: Calder, Philip C. title: n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients date: 2004 words: 10029.0 sentences: 518.0 pages: flesch: 43.0 cache: ./cache/cord-006518-al94gxjw.txt txt: ./txt/cord-006518-al94gxjw.txt summary: More recent studies showed that EPA did not induce TNF-α, IL-1β, or IL-1α (68) or IL-6 (69) in osteoblasts, and even countered the upregulating effect of arachidonic acid (68) ; that EPA and DHA could totally abolish cytokine-induced up-regulation of TNF-α, IL-1α, and IL-1β in cultured bovine chondrocytes and in human osteoarthritic cartilage explants (93, 94) ; and that EPA or fish oil inhibited endotoxin-induced TNF-α production by monocytes (111) (112) (113) (114) . Animal feeding studies with fish oil support the observations made in cell culture with respect to the effects of long-chain n-3 FA on NFκB activation and inflammatory cytokine production. Several studies in humans involving supplementation of the diet with fish oil have demonstrated decreased production of TNF-α, IL-1β, and IL-6 by endotoxin-stimulated monocytes or mononuclear cells (a mixture of lymphocytes and monocytes) (80) (81) (82) 119) . abstract: Excessive or inappropriate inflammation and immunosuppression are components of the response to surgery, trauma, injury, and infection in some individuals and these can lead, progressively, to sepsis and septic shock. The hyperinflammation is characterized by the production of inflammatory cytokines, arachidonic acid-derived eicosanoids, and other inflammatory mediators, while the immunosuppression is characterized by impairment of antigen presentation and of T helper cell type-1 responses. Long-chain n−3 FA from fish oil decrease the production of inflammatory cytokines and eicosanoids. They act both directly (by replacing arachidonic acid as an eicosanoid substrate and by inhibiting arachidonic acid metabolism) and indirectly (by altering the expression of inflammatory genes through effects on transcription factor activation). Thus, long-chain n−3 FA are potentially useful anti-inflammatory agents and may be of benefit in patients at risk of developing sepsis. As such, an emerging application of n−3 FA is in surgical or critically ill patients where they may be added to parenteral or enteral formulas. Parenteral or enteral nutrition including n−3 FA appears to preserve immune function better than standard formulas and appears to partly prevent some aspects of the inflammatory response. Studies to date are suggestive of clinical benefits from these approaches, especially in postsurgical patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101959/ doi: 10.1007/s11745-004-1342-z id: cord-346389-gbmnoo84 author: Callender, Lauren A. title: The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19 date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Evidence from the global outbreak of SARS-CoV-2 has clearly demonstrated that individuals with pre-existing comorbidities are at a much greater risk of dying from COVID-19. This is of great concern for individuals living with these conditions, and a major challenge for global healthcare systems and biomedical research. Not all comorbidities confer the same risk, however, many affect the function of the immune system, which in turn directly impacts the response to COVID-19. Furthermore, the myriad of drugs prescribed for these comorbidities can also influence the progression of COVID-19 and limit additional treatment options available for COVID-19. Here, we review immune dysfunction in response to SARS-CoV-2 infection and the impact of pre-existing comorbidities on the development of COVID-19. We explore how underlying disease etiologies and common therapies used to treat these conditions exacerbate COVID-19 progression. Moreover, we discuss the long-term challenges associated with the use of both novel and repurposed therapies for the treatment of COVID-19 in patients with pre-existing comorbidities. url: https://www.ncbi.nlm.nih.gov/pubmed/32903476/ doi: 10.3389/fimmu.2020.01991 id: cord-257600-0plhquk9 author: Calles, Antonio title: Outcomes of COVID-19 in Patients With Lung Cancer Treated in a Tertiary Hospital in Madrid date: 2020-09-16 words: 6981.0 sentences: 353.0 pages: flesch: 47.0 cache: ./cache/cord-257600-0plhquk9.txt txt: ./txt/cord-257600-0plhquk9.txt summary: Differences in health-care systems, in the incidence and prevalence of SARS-CoV-2 infection by geographic regions, and patient access to intensive support care -including MVand treatment with antivirals or anti-IL6/IL1 agents may ultimately influence outcomes in patients with lung cancer affected by COVID-19. We aimed to describe the clinical characteristics of lung cancer patients with COVID-19 attended in a tertiary hospital in Madrid, one of the most hit regions by coronavirus in the world so far, and analyze factors associated with worse outcome, including type of treatment receiving at the time of COVID-19 diagnosis. We performed SARS-CoV-2 RT-PCR to every suspicious case and included all lung cancer patients attended at our hospital (emergency room, hospitalization, ambulatory office, day care area). Data from Wuhan, in China, showed that active cancer treatment received in the 14 days before SARS-CoV-2 infection had an increase on the risk of severe outcomes of COVID-19 (HR 4.079, 95%CI, 1.086-15.322; p = 0.037) (9) . abstract: Background: Cancer patients represent a vulnerable population for COVID-19 illness. We aimed to analyze outcomes of lung cancer patients affected by COVID-19 in a tertiary hospital of a high-incidence region during the pandemic. Methods: We annotated 23 lung cancer patients consecutively diagnosed with COVID-19 at our institution (HGUGM; Madrid, Spain) between March 4th, 2020 and May 12th, 2020. Only patients with a confirmatory SARS-CoV-2 RT-PCR were included in the study. Results: All patients had at least 1 COVID-19 related symptom; cough (48%), shortness of breath (48%), fever (39%), and low-grade fever (30%) were the most common. Time from symptoms onset to first positive SARS-CoV-2 PCR was 5.5 days (range 1–17), with 13% of cases needed from a 2nd PCR to confirm diagnosis. There was a high variability on thoracic imaging findings, with multilobar pneumonia as the most commonly found pattern (74%). Main lab test abnormalities were low lymphocytes count (87%), high neutrophil to lymphocyte ratio -NLR- (78%), and elevated inflammatory markers: fibrinogen (91%), c-reactive protein -CRP- (87%), and D-dimer (70%). In our series, hospitalization rate was 74%, 39% of patients developed acute respiratory distress syndrome (ARDS), and the case-fatality rate was 35% (8/23). 87% of patients received anti-viral treatment (87% hydroxychloroquine, 74% lopinavir/ritonavir, 13% azithromycin), 43% corticosteroids, 26% interferon-β, 4% tocilizumab, and 82% of hospitalized patients received anticoagulation. High-oxygen requirements were needed in 39% of patients, but only 1 pt was admitted for invasive MV and was discharged 42 days after admission. Multiple variables related to tumor status, clinical baseline conditions, and inflammation markers were associated with mortality but did not remain statistically significant in a multivariate model. In patients with lung cancer receiving systemic therapy (n = 242) incidence and mortality from COVID-19 were 4.5, and 2.1%, respectively, with no differences found by type of treatment. Conclusions: Lung cancer patients represent a vulnerable population for COVID-19, according to the high rate of hospitalization, onset of ARDS, and high mortality rate. Although larger series are needed, no differences in mortality were found by type of cancer treatment. Measures to minimize the risk of SARS-CoV-2 infection remain key to protect lung cancer patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33042826/ doi: 10.3389/fonc.2020.01777 id: cord-022173-kb6mez61 author: Calvillo Batllés, P. title: Hematologic neoplasms: Interpreting lung findings in chest computed tomography() date: 2015-11-06 words: 5374.0 sentences: 293.0 pages: flesch: 37.0 cache: ./cache/cord-022173-kb6mez61.txt txt: ./txt/cord-022173-kb6mez61.txt summary: Chest HRCT plays a fundamental role---urgent when there are clinical signs of severity and early (<24 h) in the absence of a response to antibiotics therapy in 72---96 h because treatment of a possible invasive fungal infection (IFI) requires an early administration, a determinant factor for prognosis. 20, 40 Noninfectious complications secondary to treatment In the 6 h following the transfusion of blood products, the sudden appearance of consolidations simulating an edema and accompanying a respiratory failure usually reflect acute pulmonary damage (APD) called TRALI (transfusion-related alveolar lung injury) which associates high mortality rates. In patients with HP the thoracic HRCT helps us come close to the differential diagnosis of infectious and non-infectious pulmonary complications by integrating image findings and clinical data. abstract: Lung disease is very common in patients with hematologic neoplasms and varies in function of the underlying disease and its treatment. Lung involvement is associated with high morbidity and mortality, so it requires early appropriate treatment. Chest computed tomography (CT) and the analysis of biologic specimens are the first line diagnostic tools in these patients, and sometimes invasive methods are necessary. Interpreting the images requires an analysis of the clinical context, which is often complex. Starting from the knowledge about the differential diagnosis of lung findings that radiologists acquire during training, this article aims to explain the key clinical and radiological aspects that make it possible to orient the diagnosis correctly and to understand the current role of CT in the treatment strategy for this group of patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153726/ doi: 10.1016/j.rxeng.2015.09.001 id: cord-278943-f80ucqqp author: Calvillo-Argüelles, Oscar title: Modified Routine Cardiac Imaging Surveillance of Adult Cancer Patients and Survivors during the COVID-19 Pandemic date: 2020-04-16 words: 1648.0 sentences: 97.0 pages: flesch: 39.0 cache: ./cache/cord-278943-f80ucqqp.txt txt: ./txt/cord-278943-f80ucqqp.txt summary: Many routine tests have relatively low yield for detecting abnormal findings or modifying clinical care in asymptomatic patients.(3) Thus, it may be possible to adopt temporary measures during this pandemic which strike a balance between the early detection and prevention of cancer therapy related cardiac dysfunction (CTRCD) and risk of COVID-19 transmission. Thus, with anthracycline initiation, regardless of dose, it may be reasonable to prioritize baseline cardiac imaging for patients with: 1) established or suspected CVD based on past medical history (e.g. myocardial infarction, cardiomyopathy, arrhythmia, moderate or greater valvular disease); 2) signs or symptoms of cardiac dysfunction; 3) ≥2 risk factors for CTRCD, including age ≥ 60 years, hypertension, diabetes, dyslipidemia, smoking, or obesity. The optimal surveillance regimen during anthracycline chemotherapy remains incompletely In patients who develop CTRCD and require cardiac treatments and/or withholding of cancer therapy, repeat imaging should continue as per institutional standard of care.(10) abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2666087320300661?v=s5 doi: 10.1016/j.jaccao.2020.04.001 id: cord-287648-nhsn4cru author: Cameli, Matteo title: Usefulness of echocardiography to detect cardiac involvement in COVID‐19 patients date: 2020-07-12 words: 3041.0 sentences: 160.0 pages: flesch: 36.0 cache: ./cache/cord-287648-nhsn4cru.txt txt: ./txt/cord-287648-nhsn4cru.txt summary: Therefore, the use of echocardiography, according to the safety local protocols and ensuring the use of personal protective equipment, could be useful firstly to discriminate between primary cardiac disease or COVID‐19–related myocardial damage, and then for assessing and monitoring COVID‐19 cardiovascular complications: acute myocarditis and arrhythmias, acute heart failure, sepsis‐induced myocardial impairment, and right ventricular failure derived from treatment with high‐pressure mechanical ventilation. 7 In two studies by Shi et al 8 and Guo et al, 9 among 460 and 187 patients hospitalized for COVID-19, respectively, 20% and 28% had acute myocardial injury, which was associated with higher mortality and incidence of complications, such as acute respiratory distress syndrome (ARDS), malignant arrhythmias, acute renal injury, and coagulopathy. 21 Accordingly, current reports suggest that the majority of COVID-19 patients with myocardial injury without evidence of epicardial coronary artery thrombosis, show imaging data supporting the diagnosis of acute myocarditis 21, 22 ; also, cases of fulminant myocarditis and fatal arrhythmias have been described. abstract: Coronavirus disease 2019 (COVID‐19) outbreak is a current global healthcare burden, leading to the life‐threatening severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). However, evidence showed that, even if the prevalence of COVID‐19 damage consists in pulmonary lesions and symptoms, it could also affect other organs, such as heart, liver, and spleen. Particularly, some infected patients refer to the emergency department for cardiovascular symptoms, and around 10% of COVID‐19 victims had finally developed heart injury. Therefore, the use of echocardiography, according to the safety local protocols and ensuring the use of personal protective equipment, could be useful firstly to discriminate between primary cardiac disease or COVID‐19–related myocardial damage, and then for assessing and monitoring COVID‐19 cardiovascular complications: acute myocarditis and arrhythmias, acute heart failure, sepsis‐induced myocardial impairment, and right ventricular failure derived from treatment with high‐pressure mechanical ventilation. The present review aims to enlighten the applications of transthoracic echocardiography for the diagnostic and therapeutic management of myocardial damage in COVID‐19 patients. url: https://doi.org/10.1111/echo.14779 doi: 10.1111/echo.14779 id: cord-344508-a67vsux2 author: Campanile, Fabio Cesare title: Acute cholecystitis during COVID-19 pandemic: a multisocietary position statement date: 2020-06-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Following the spread of the infection from the new SARS-CoV2 coronavirus in March 2020, several surgical societies have released their recommendations to manage the implications of the COVID-19 pandemic for the daily clinical practice. The recommendations on emergency surgery have fueled a debate among surgeons on an international level. We maintain that laparoscopic cholecystectomy remains the treatment of choice for acute cholecystitis, even in the COVID-19 era. Moreover, since laparoscopic cholecystectomy is not more likely to spread the COVID-19 infection than open cholecystectomy, it must be organized in such a way as to be carried out safely even in the present situation, to guarantee the patient with the best outcomes that minimally invasive surgery has shown to have. url: https://doi.org/10.1186/s13017-020-00317-0 doi: 10.1186/s13017-020-00317-0 id: cord-301590-70qmpccs author: Campos, António title: The Paradigm Shift of Ophthalmology in the COVID-19 Era date: 2020-09-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To describe how a fixed regimen of intravitreal injections (IVI) was helpful to continue activity during the COVID-19 outbreak and lockdown and to address basic conditions to resume activity. METHODS: A fixed regimen of IVI was conceived to significantly reduce the number of visits while keeping a number of injections related to the best outcomes. We retrospectively collected data of surgeries performed in 2019 and in the first seven months of 2020 and from OCTs in the first semester of 2020. RESULTS: IVI per month, from January to July 2020, were 304, 291, 256, 204, 276, 297 and 322, respectively. Phacoemulsification surgeries in the same period were 397, 408, 171, 0, 304, 391 and 389. Posterior vitrectomies were 23, 21, 17, 10, 21, 28 and 25. Laser sessions were 44, 26, 33, 17, 23 and 33, respectively. OCTs dropped from a mean of 25.7 per day in the first half of March 2020 to 5.8 per day in the second half of March. A mean of 6.5 OCTs per day was made in April, rising to 19.1 in May and 39.5 in June. CONCLUSION: It was possible to keep the ophthalmological activity during the pandemic outbreak due to the existence of a pre-scheduled fixed regimen for IVI and to the availability of personal protective equipment. The air-borne nature of the peril we are facing addresses the need to evaluate the physical conditions of health facilities, including ventilation, size of waiting and consult rooms and the need to avoid elevators. url: https://doi.org/10.2147/opth.s267427 doi: 10.2147/opth.s267427 id: cord-270124-tqhkzd2w author: Campos, Fábio Guilherme title: General recommendations to the colorectal surgeon during the COVID-19 pandemic date: 2020-06-19 words: 2196.0 sentences: 123.0 pages: flesch: 46.0 cache: ./cache/cord-270124-tqhkzd2w.txt txt: ./txt/cord-270124-tqhkzd2w.txt summary: The present article aimed to bring to the colorectal surgeon the current recommendations and general safety measures in order to prevent infection dissemination, to improve surgical planning in terms of timing and specific technical aspects. Since its appearance in China, in December of last year, the infection J o u r n a l P r e -p r o o f caused by the new coronavirus, SARS-CoV-2 (known as COVID-19), has spread rapidly and was declared a pandemic by the World Health Organization (WHO) in March of this year. While there is an increasing number of new cases and deaths, there is a recommendation to delay elective surgeries (including selected cancer cases) in order to provide medical resources and beds (including ICUs), increase the hospital areas that can be used, concentrate hospital activities for emergency care and, mainly, reduce the chances of cross-infection of doctors, patients and visitors. [15] General recommendations and care measures during surgical procedures Any procedure performed on a COVID-19-positive or suspected patient must be performed in a specific room. abstract: Abstract The COVID-19 pandemic has shown our country in an unfavorable light, as Brazil has reported the second highest number of deaths to date. When the social isolation phase is finished, professional activities (including the medical ones) will resume their routines and the specialist must be updated in order to provide effective and safe care. Although many published recommendations are based on low levels of evidence, disclosing them has become necessary, since the coronavirus infection may affect operative outcomes. Overall, it is suggested that physicians adopt preventive measures, starting with the medical appointment, and extending them to the surgical procedure. Furthermore, it is also necessary to provisionally change criteria for operative indications and conducts. Currently, postponing elective surgeries seems to be a universally agreed decision. Moreover, we need to establish the early diagnosis of the viral infection, before or after the surgery. Several safety measures related to minimally-invasive procedures have been reported, disclosing the risks of aerosol dissemination by the pneumoperitoneum and smoke from energy-powered devices. The present article aimed to bring to the colorectal surgeon the current recommendations and general safety measures in order to prevent infection dissemination, to improve surgical planning in terms of timing and specific technical aspects. url: https://api.elsevier.com/content/article/pii/S2237936320300496 doi: 10.1016/j.jcol.2020.06.001 id: cord-278106-ev1nx60h author: Cancarevic, Ivan title: Coronavirus Disease 2019 (COVID-19) in Cancer Patients date: 2020-04-26 words: 2479.0 sentences: 130.0 pages: flesch: 50.0 cache: ./cache/cord-278106-ev1nx60h.txt txt: ./txt/cord-278106-ev1nx60h.txt summary: The Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the most talked-about clinical entity in early 2020. Management presents its own set of challenges, including but not limited to, deciding whether postponing cancer treatment until the infection resolves is going to benefit the patient and how to organize all aspects of patient care when social contact is as limited as it is for patients newly diagnosed with COVID-19. found that the prevalence of cancer among patients infected with SARS-CoV-2 (COVID-19) was higher than in the general population [12] . We would strongly encourage clinicians to keep reporting any cases of cancer patients infected with SARS-CoV-2, their management, and the outcome in order to further our understanding of this complex issue. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges The treatment and outcome of a lung cancer patient infected with SARS-CoV-2 abstract: The Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the most talked-about clinical entity in early 2020. As an infection that spreads easily and has a significant mortality rate, it has caused global panic rarely seen before. Many of the measures taken by governments worldwide will have long-lasting impacts on the wellbeing of the population at large. It has been widely reported that the most vulnerable patients have been most negatively affected by SARS-CoV-2 (COVID-19). In this study, we have tried to search the currently available data on the outcomes of infected cancer patients. Most of the data points to the very challenging nature of treating such patients. Their overall outcomes seem to be worse than in the general population, and it may be difficult to differentiate which potential complications are a result of the primary oncologic disease versus the infection. Management presents its own set of challenges, including but not limited to, deciding whether postponing cancer treatment until the infection resolves is going to benefit the patient and how to organize all aspects of patient care when social contact is as limited as it is for patients newly diagnosed with COVID-19. We believe that as more data becomes available, it is going to be necessary to publish detailed guidelines on how to approach this unique clinical challenge. url: https://doi.org/10.7759/cureus.7835 doi: 10.7759/cureus.7835 id: cord-257433-qgkwylmk author: Candeloro, Elisa title: An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era date: 2020-10-15 words: 3560.0 sentences: 170.0 pages: flesch: 58.0 cache: ./cache/cord-257433-qgkwylmk.txt txt: ./txt/cord-257433-qgkwylmk.txt summary: We collected the data on the patients that were referred to our hospital from March 9 to April 19 2020 either for ischemic or hemorrhagic stroke or for intracerebral cerebral hemorrhage (ICH), i.e., a timeframe of 42 days following the promulgation of the decree of the Lombardy Governor for the institution of the hub-and-spoke system. For each patient we acknowledged how he/she had reached the hospital (without or with the regional emergency transportation system AREU), the individual risk factors, the kind of stroke according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification (4), the location of the stroke according to Oxfordshire Classification (OCSP) (5), the therapeutic procedures (IVT, EVT, CEA), and a justification in case no procedure was undertaken, the NIH Stroke Scale (NIHSS) score before and after the procedure. abstract: During the COVID-19 outbreak, the Neurology and Stroke Unit (SU) of the hospital of Varese had to serve as a cerebrovascular hub, meaning that the referral area for the unit doubled. The number of beds in the SU was increased from 4 to 8. We took advantage of the temporary suspension of the out-patient clinic and reshaped our activity to guarantee the 24/7 availability of recombinant tissue Plasminogen Activator (rtPA) intravenous therapy (IVT) in the SU, and to ensure we were able to admit patients to the SU as soon as they completed endovascular treatment (EVT). In 42 days, 46 stroke patients were admitted to our hospital, and 34.7% of them underwent IVT and/or EVT, which means that we treated 0.38 patients per day; in the baseline period from 2016 to 2018, these same figures had been 23.5% and 0.23, respectively. The mean values of the door-to-first CT/MRI and the door-to-groin puncture, but not of the onset-to-door and the door-to-needle periods were slightly but significantly longer than those observed in the baseline period in 276 patients. On an individual basis, only one patient exceeded the door-to-groin puncture time limit computed from the baseline period by about 10 min. None of the patients had a major complication following the procedures. None of the patients was or became SARS-CoV2 positive. In conclusion, we were able to manage the new hub-and-spoke system safely and without significant delays. The reshaping of the SU was made possible by the significant reduction of out-patient activity. The consequences of this reduction are still unknown but eventually, this emergency will suggest ways to reconsider the management and the allocation of health system resources. url: https://www.ncbi.nlm.nih.gov/pubmed/33178094/ doi: 10.3389/fneur.2020.01029 id: cord-265262-r01u4jr6 author: Cannarella, Rossella title: Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients date: 2020-10-13 words: 8737.0 sentences: 471.0 pages: flesch: 47.0 cache: ./cache/cord-265262-r01u4jr6.txt txt: ./txt/cord-265262-r01u4jr6.txt summary: Furthermore, recent findings on novel coronavirus disease (COVID-19) epidemiology have shown a greater mortality in male compared with female patients and a role of T in promoting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection of the host cells has been demonstrated. To accomplish the aims of the study, we performed a search on PubMed, Scopus, Ovid and Science Direct, and the following keywords were used: hypogonadism, TD, TRT, blood pressure, hypertension, ischemic heart disease, heart failure, stroke, obesity, insulin, diabetes, metabolic disorders, prostatic hyperplasia, prostate cancer, COVID-19, and SARS-CoV2. 45 In 2017, a meta-analysis including 39 randomized controlled trials (RCTs) and 10 observational studies with a total of about 5500 patients did not find any significant association between TRT and myocardial infarction, stroke, or mortality, even if the quality of the evidence was low. abstract: Male hypogonadism, defined as an inadequate production of testosterone (T), is associated with a greater morbidity and mortality. Epidemiological studies identified T deficiency as a risk factor for cardiovascular disease. Also, low serum T levels impact on glucose homeostasis through a worse glucose uptake, utilization, and disposal, and the general negative impact on metabolism. The aim of this review is to provide a comprehensive and updated overview of the effects of T replacement therapy on metabolic and cardiovascular systems and prostate tissue in patients with hypogonadism, including molecular mechanisms through which T exerts its actions. Furthermore, recent findings on novel coronavirus disease (COVID-19) epidemiology have shown a greater mortality in male compared with female patients and a role of T in promoting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection of the host cells has been demonstrated. Hence, the secondary aim of this review is to provide preliminary indications on the management in patients with COVID-19. url: https://doi.org/10.1177/2042018820966438 doi: 10.1177/2042018820966438 id: cord-300038-1fjb6b8e author: Cantini, Fabrizio title: Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact date: 2020-04-23 words: 1261.0 sentences: 81.0 pages: flesch: 48.0 cache: ./cache/cord-300038-1fjb6b8e.txt txt: ./txt/cord-300038-1fjb6b8e.txt summary: According to a recent report 3 , COVID-19, the disease caused by SARS-CoV-2, is characterized by three clinical patterns: no symptoms, mild to moderate disease, severe pneumonia requiring admission to Intensive Care Unit (ICU) in up to 31% of the patients 3 . On this basis, we assessed the safety of baricitinib therapy combined with lopinavir-ritonavir in moderate COVID-19 pneumonia patients and we evaluated its clinical impact. All consecutive hospitalized patients (March 16 th -30 th ) with moderate COVID-19 pneumonia, older than 18 years, were treated for 2 weeks with baricitinib tablets 4 mg/day added to ritonavirlopinavir therapy. The last consecutive patients with moderate COVID-19 pneumonia receiving standard of care therapy (lopinavir/ritonavir tablets 250 mg/bid and hydroxychloroquine 400 mg/day/orally for 2 weeks) admitted before the date of the first baricitinib-treated patient served as controls. These preliminary results on 12 patients with moderate COVID-19 pneumonia confirmed the safety of baricitinib therapy in a clinical context different from RA 7 . abstract: • Baricitinib at 4 mg/day/orally was given to 12 patients with moderate COVID-19. • In baricitinib-treated patients no adverse events were recorded, after 2 weeks. • Clinical and respiratory parameters significantly improved at 2 weeks. • None of the baricitinib-treated patients required admission to ICU. • Proper control group was missing; this is required to demonstrate the efficacy. url: https://doi.org/10.1016/j.jinf.2020.04.017 doi: 10.1016/j.jinf.2020.04.017 id: cord-006621-0fxpn7qf author: Cantwell, Tamara title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date: 2017-10-10 words: 2503.0 sentences: 159.0 pages: flesch: 38.0 cache: ./cache/cord-006621-0fxpn7qf.txt txt: ./txt/cord-006621-0fxpn7qf.txt summary: title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation The clinical relevance of the case is the scared evidence of leptospirosis-associated severe respiratory failure treated with ECMO. A high index of suspicion is needed for an adequate diagnosis of leptospirosis to implement the correct treatment, particularly in the association of respiratory failure, pulmonary hemorrhage, and an epidemiological-related context. Leptospirosis can present with a wide range of symptoms, mimicking flu, hepatitis, dengue, hanta virus cardiopulmonary syndrome, meningitis, among others, and has a specific treatment; thus, clinical suspicion must remain high and serological diagnosis should be performed. The most severe clinical form of leptospirosis is known as Weil''s disease, which is uncommon (5-10% of cases), and is characterized by hepatic, renal, and pulmonary involvement [7] [8] [9] [10] [11] . In the case presented, profound septic shock, with MOF and catastrophic ARDS, made it impossible to ventilate the patient protectively and simultaneously supply adequate oxygenation and ventilation; thus, ECMO was initiated. abstract: A previously healthy, 39-year-old obese farmer, arrived hypotensive and tachycardic, with fever, myalgia, headache, abdominal pain, diarrhea, and progressive dyspnea. Ten days before symptoms onset, he was in direct contact with mice and working in a contaminated drain. Patient laboratory showed acute kidney injury and thrombocytopenia. Chest X-ray exhibited bilateral diffuse interstitial infiltrates. First-line empirical antibiotics were started and influenza discarded. Patient evolved with severe respiratory failure, associated with hemoptysis, and rapidly severe hemodynamic compromise. Despite neuromuscular blockade and prone positioning, respiratory failure increased. Accordingly, veno-venous ECMO was initiated, with bilateral femoral extraction and jugular return. After ECMO connection, there was no significant improvement in oxygenation, and low pre-membrane saturations and low arterial PaO(2) of the membrane showed that we were out of the limits of the rated flow. Thus, a second membrane oxygenator was installed in parallel. Afterward, oxygenation improved, with subsequent perfusion enhancement. Regarding etiology, due to high suspicion index, Leptospira serology was performed, coming back positive and meropenem was maintained. The patient ultimately recovered and experience excellent outcome. The clinical relevance of the case is the scared evidence of leptospirosis-associated severe respiratory failure treated with ECMO. This experience emphasizes the importance of an optimal support, which requires enough membrane surface and flow for an obese, highly hyperdynamic patient, during this reversible disease. A high index of suspicion is needed for an adequate diagnosis of leptospirosis to implement the correct treatment, particularly in the association of respiratory failure, pulmonary hemorrhage, and an epidemiological-related context. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102126/ doi: 10.1007/s10047-017-0998-x id: cord-009667-8r8j0h08 author: Cao, Bin title: Diagnosis and treatment of community‐acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association date: 2017-09-26 words: 11049.0 sentences: 657.0 pages: flesch: 33.0 cache: ./cache/cord-009667-8r8j0h08.txt txt: ./txt/cord-009667-8r8j0h08.txt summary: 13, 17 Recently, the results of 2 multicenter Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CAR-TIPS) studies in adults conducted in urban tertiary hospitals in China showed that 88.1%-91.3% of S. Step 3: Predict the potential pathogens of CAP and risks of antibiotic resistance ( Table 2) : considering patient age, season of onset, underlying diseases and risk factors, symptoms or signs, characteristics of chest imaging (X-ray film or CT), laboratory tests, severity of CAP, prior antibacterial therapies and so on. After clinical diagnosis of CAP is established, and etiological test and sampling arranged appropriately, the most potential pathogens should be assessed in terms of patient age, underlying disease, clinical characteristics, results of laboratory and radiography tests, severity of disease, hepatic and renal functions, and history of medication and antimicrobial susceptibility profile, then evaluate the risk for antibiotic resistance, select the appropriate anti-infective agent (s) and dosing regimen ( Table 6 ). abstract: Community‐acquired pneumonia (CAP) in adults is an infectious disease with high morbidity in China and the rest of the world. With the changing pattern in the etiological profile of CAP and advances in medical techniques in diagnosis and treatment over time, Chinese Thoracic Society of Chinese Medical Association updated its CAP guideline in 2016 to address the standard management of CAP in Chinese adults. Extensive and comprehensive literature search was made to collect the data and evidence for experts to review and evaluate the level of evidence. Corresponding recommendations are provided appropriately based on the level of evidence. This updated guideline covers comprehensive topics on CAP, including aetiology, antimicrobial resistance profile, diagnosis, empirical and targeted treatments, adjunctive and supportive therapies, as well as prophylaxis. The recommendations may help clinicians manage CAP patients more effectively and efficiently. CAP in pediatric patients and immunocompromised adults is beyond the scope of this guideline. This guideline is only applicable for the immunocompetent CAP patients aged 18 years and older. The recommendations on selection of antimicrobial agents and the dosing regimens are not mandatory. The clinicians are recommended to prescribe and adjust antimicrobial therapies primarily based on their local etiological profile and results of susceptibility testing, with reference to this guideline. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162259/ doi: 10.1111/crj.12674 id: cord-268974-7bqh1yas author: Capitelli-McMahon, Helen title: Characterising non-melanoma skin cancer undergoing surgical management during the COVID-19 pandemic date: 2020-11-02 words: 482.0 sentences: 29.0 pages: flesch: 52.0 cache: ./cache/cord-268974-7bqh1yas.txt txt: ./txt/cord-268974-7bqh1yas.txt summary: title: Characterising non-melanoma skin cancer undergoing surgical management during the COVID-19 pandemic Our findings show that throughout the height of the COVID-19 pandemic our department saw significantly larger NMSC lesions, with a higher proportion of these being SCCs that required more complex reconstruction following excision. Larger, more invasive lesions may be likely to result in an increase in incomplete excision margins. Despite prioritisation of oncological services throughout the pandemic thus far, our findings show substantial differences in the patients accessing skin oncology services in our centre. It appears that current delays to definitive surgical treatment of smaller, less aggressive BCCs may mean patients are missing the opportunity to benefit from early excision of these lesions. Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic Global incidence of incomplete surgical excision in adult patients with non-melanoma skin cancer: study protocol for a systematic review and meta-analysis of observational studies abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1748681520305398?v=s5 doi: 10.1016/j.bjps.2020.10.042 id: cord-262236-1lilrqts author: Capone, Stephen title: Characterization of Critically Ill COVID-19 Patients at a Brooklyn Safety-Net Hospital date: 2020-08-17 words: 3447.0 sentences: 171.0 pages: flesch: 41.0 cache: ./cache/cord-262236-1lilrqts.txt txt: ./txt/cord-262236-1lilrqts.txt summary: There was no statistically significant difference in overall survival based on ethnicity, healthcare status, or individual medical comorbidities, although a negative trend exists for diabetes. There was no statistically significant difference in overall survival based on ethnicity, healthcare status, or individual medical comorbidities, although a negative trend exists for diabetes. The purpose of this study was to explore the disease characteristics in a Brooklyn safety-net hospital affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and the clinical course and outcomes of this uniquely diverse population. Deceased patients were then isolated and a multiple linear regression analysis was performed to compare each comorbidity to the overall days to death which yielded no statistically significant results. We do note a trend towards decreased survival in patients with diabetes (p=0.12), but no individual factor showed a statistically significant impact on overall mortality or median OS. abstract: Background The novel coronavirus disease 2019 (COVID-19) pandemic continues to spread across the country with over 3 million cases and 150,000 deaths in the United States as of July 2020. Outcomes have been poor, with reported admission rates to the intensive care team of 5% in China and mortality among critically ill patients of 50% in Seattle. Here we explore the disease characteristics in a Brooklyn safety-net hospital affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Methods A retrospective chart review of COVID-19 positive patients at The Brooklyn Hospital Center who were treated by the intensive care team prior to April 20, 2020. Data was extracted from the electronic health record, analyzed and correlated for outcome. Results Impact of various clinical treatments was assessed, showing no change in median overall survival (OS) of both hydroxychloroquine with azithromycin or vitamin C with zinc. Supplemental therapies were used in selected patients, and some were shown to increase median OS and patients requiring vasopressor support or invasive mechanical ventilation showed decreased OS. There was no statistically significant difference in overall survival based on ethnicity, healthcare status, or individual medical comorbidities, although a negative trend exists for diabetes. Despite this, there is a trend towards increasingly poor prognosis based on the number of comorbidities and Class 3 obesity. Conclusions Despite the fact that we show no significant differences in mortality based on ethnicity, insurance status, or individual medical comorbidities, we show a high overall mortality. There is also a trend towards increased overall mortality in Class 3 obesity, which should be further investigated. We suggest that these findings may be attributed to both socioeconomic factors and an increased incidence of total medical comorbidities in our patient population. url: https://www.ncbi.nlm.nih.gov/pubmed/32850261/ doi: 10.7759/cureus.9809 id: cord-293730-dlqo6fep author: Caratozzolo, Salvatore title: The impact of COVID-19 on health status of home-dwelling elderly patients with dementia in East Lombardy, Italy: results from COVIDEM network date: 2020-09-12 words: 3723.0 sentences: 179.0 pages: flesch: 47.0 cache: ./cache/cord-293730-dlqo6fep.txt txt: ./txt/cord-293730-dlqo6fep.txt summary: Information on age, sex, education, clinical characteristics including dementia diagnosis, dementia severity by Clinical Dementia Rating scale (CDR) [6] , Mini Mental State Examination (MMSE) [7] , and Basic Activity of Daily Life (BADL) [8] , walking, total number of chronic diseases and type of diseases among a pre-defined list (hypertension, COPD, renal disease, heart disease, cancer, gastrointestinal diseases, hepatic disease, diabetes, thyroid disorders, arthritis), number of drugs, and flu vaccination were obtained from previous medical records based on the last recorded visit at CDCD. Findings from our study showed that COVID-19 affected over 10% of home-dwelling older patients with dementia who showed high risk of adverse outcomes, such as unplanned hospitalization and mortality. Findings of this study are in line with previous reports [10] [11] [12] and add new insight by showing that COVID-19 exerted a relevant impact on health status of home-dwelling elderly patients with dementia determining a high rate of hospitalization and mortality. abstract: BACKGROUND: COVID-19 outbreak has led to severe health burden in the elderly. Age, morbidity and dementia have been associated with adverse outcome. AIMS: To evaluate the impact of COVID-19 on health status in home-dwelling patients. METHODS: 848 home-dwelling outpatients with dementia contacted from April 27 to 30 and evaluated by a semi-structured interview to evaluate possible health complication due to COVID-19 from February 21 to April 30. Age, sex, education, clinical characteristics (including diagnosis of dementia) and flu vaccination history were obtained from previous medical records. Items regarding change in health status and outcome since the onset of the outbreak were collected. COVID-19 was diagnosed in patients who developed symptoms according to WHO criteria or tested positive at nasal/throat swab if hospitalized. Unplanned hospitalization, institutionalization and mortality were recorded. RESULTS: Patients were 79.7 years old (SD 7.1) and 63.1% were females. Ninety-five (11.2%) patients developed COVID-19-like symptoms. Non COVID-19 and COVID-19 patients differed for frequency of diabetes (18.5% vs. 37.9%, p < 0.001), COPD (7.3% vs. 18.9%, p < 0.001), and previous flu vaccination (56.7% vs. 37.9%, p < 0.001). Diabetes and COPD were positively associated with COVID-19, whereas higher dementia severity and flu vaccination showed an inverse association. Among COVID-19 patients, 42 (44.2%) were hospitalized while 32 (33.7%) died. Non COVID-19 patients’ hospitalization and mortality rate were 1.9% and 1.2%, respectively. COVID-19 and COPD were significantly associated with the rate of mortality. DISCUSSION/CONCLUSIONS: A high proportion of adverse outcome related to COVID-19 was observed in home-dwelling elderly patients with dementia. Active monitoring though telehealth programs would be useful particularly for those at highest risk of developing COVID-19 and its adverse outcomes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40520-020-01676-z) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32918696/ doi: 10.1007/s40520-020-01676-z id: cord-103686-er8llst4 author: Carboni Bisso, I. title: Influenza season 2019: analysis of 143 hospitalized cases date: 2020-09-18 words: 2426.0 sentences: 164.0 pages: flesch: 50.0 cache: ./cache/cord-103686-er8llst4.txt txt: ./txt/cord-103686-er8llst4.txt summary: Among the patients hospitalized due to influenza severe respiratory infection, it has been estimated that 29 to 6% require admission to the intensive care unit (ICU). In Argentina, there is a significant absence of data regarding influenza severe respiratory disease and, therefore, a lack of knowledge about the impact of this disease at health institutions, hospital mortality, and the profile of patients requiring ICU. Thus, the objective of this work is to describe the history of comorbidities as well as the clinical, laboratory and imaging findings of patients who required hospitalization in a general ward or ICU during 2019 in a high-complexity care hospital from Buenos Aires, capital of Argentina. In this cohort study, we reported the clinical characteristics and risk factors associated with clinical outcomes in patients with laboratory-confirmed influenza who required hospitalization during 2019. abstract: Introduction Influenza virus infection is a latent public health problem, affecting millions of people through the planet, and it is an important cause of morbidity and mortality. In Argentina, there is a significant absence of data regarding influenza severe respiratory disease and, therefore, a lack of knowledge about the impact of this disease at health institutions. Objectives Analysis of clinical characteristics, image findings and laboratory variables in patients with influenza viruses during 2019. Methods Retrospective, single-centre study, we analyzed all confirmed cases of influenza in a high complexity hospital from Buenos Aires. Results 143 patients with influenza virus were hospitalized in this period of time. The 98.6% were infected by type A influenza, and most of them 61.5% were H1N1 subtype. Median age was 71 years (IQR 60 - 82), 77.6% were older than 70 years, and 88.1% had at least one coexisting illness. 39.1% of the patients required intensive care, 11.1% invasive mechanical ventilation and 4.1% died during hospitalization. Conclusion Mortality and severity were similar to previous series of non-pandemic influenza. Analysis of annual data would be valuable in order to document the severity of influenza hospitalizations by age-group and comorbidities according to the circulating influenza viruses. url: http://medrxiv.org/cgi/content/short/2020.09.16.20195974v1?rss=1 doi: 10.1101/2020.09.16.20195974 id: cord-290947-5ewpvo4j author: Carda, Stefano title: The role of physical and rehabilitation medicine in the COVID-19 pandemic: the clinician''s view date: 2020-04-18 words: 1545.0 sentences: 85.0 pages: flesch: 43.0 cache: ./cache/cord-290947-5ewpvo4j.txt txt: ./txt/cord-290947-5ewpvo4j.txt summary: The Chinese Center for Disease Control recently published data on 44,672 patients infected with SARS-CoV-2 (1) , showing that 88% of patients were < 70 years old, with an overall mortality rate of 2%, but 19% of cases needed hospitalization in an intensive care unit (ICU). The proportion of patients with COVID-19-related disability will be rapidly growing, and a prompt response from physical medicine and rehabilitation (PMR) specialists is crucial to reduce disability and help re-establish and optimize the function of the acute hospital setting. The most common forms are 1) mild: no dyspnea, no low blood oxygen saturation (SatO2); 2) moderate: dyspnea, SatO2 94% to 98%, radiological signs of pneumonia; 3) severe: dyspnea, SatO2 ≤ 93%, respiratory rate (RR) >30/min, radiological progression of lesions, with O2 supplementation required, eventually with non-invasive ventilation; and 4) critical: patients need mechanical ventilation. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32315802/ doi: 10.1016/j.rehab.2020.04.001 id: cord-308252-qwoo7b1l author: Cardinale, Vincenzo title: Intestinal permeability changes with bacterial translocation as key events modulating systemic host immune response to SARS-CoV-2: A working hypothesis date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The microbiota-gut-liver-lung axis plays a bidirectional role in the pathophysiology of a number of infectious diseases. During the course of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and 2 (SARS-CoV-2) infection, this pathway is unbalanced due to intestinal involvement and systemic inflammatory response. Moreover, there is convincing preliminary evidence linking microbiota-gut-liver axis perturbations, proinflammatory status, and endothelial damage in noncommunicable preventable diseases with coronavirus disease 2019 (Covid-19) severity. Intestinal damage due to SARS-CoV-2 infection, systemic inflammation-induced dysfunction, and IL-6-mediated diffuse vascular damage may increase intestinal permeability and precipitate bacterial translocation. The systemic release of damage- and pathogen-associated molecular patterns (e.g. lipopolysaccharides) and consequent immune-activation may in turn auto-fuel vicious cycles of systemic inflammation and tissue damage. Thus, intestinal bacterial translocation may play an additive/synergistic role in the cytokine release syndrome in Covid-19. This review provides evidence on gut-liver axis involvement in Covid-19 as well as insights into the hypothesis that intestinal endotheliitis and permeability changes with bacterial translocation are key pathophysiologic events modulating systemic inflammatory response. Moreover, it presents an overview of readily applicable measures for the modulation of the gut-liver axis and microbiota in clinical practice. url: https://api.elsevier.com/content/article/pii/S1590865820304692 doi: 10.1016/j.dld.2020.09.009 id: cord-304791-wv4qu9xm author: Carfora, Vincenzo title: Anticoagulant treatment in COVID-19: a narrative review date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The actual Coronavirus Disease (COVID 19) pandemic is due to Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the coronavirus family. Besides the respiratory involvement, COVID 19 patients frequently develop a pro-coagulative state caused by virus-induced endothelial dysfunction, cytokine storm and complement cascade hyperactivation. It is common to observe diffuse microvascular thrombi in multiple organs, mostly in pulmonary microvessels. Thrombotic risk seems to be directly related to disease severity and worsens patients’ prognosis. Therefore, the correct understanding of the mechanisms underlying COVID-19 induced prothrombotic state can lead to a thorough assessment of the possible management strategies. Hence, we review the pathogenesis and therapy of COVID 19-related thrombosis disease, focusing on the available evidence on the possible treatment strategies and proposing an algorithm for the anticoagulation strategy based on disease severity. url: https://www.ncbi.nlm.nih.gov/pubmed/32809158/ doi: 10.1007/s11239-020-02242-0 id: cord-338419-n8cmv8mf author: Carmelo, Juliana de Carvalho title: Impact of COVID-19 on the daily routine of radiology clinics date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33005584/ doi: 10.5624/isd.2020.50.3.261 id: cord-287520-51kmd2ds author: Carneiro, Arie title: Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date: 2020-05-20 words: 4537.0 sentences: 282.0 pages: flesch: 49.0 cache: ./cache/cord-287520-51kmd2ds.txt txt: ./txt/cord-287520-51kmd2ds.txt summary: Therefore, most worldwide authorities are recommending to avoid, as much as possible, patient''s elective visits to hospitals, as well as a judicious use of the operating room in order to mitigate the strain put on the health system. If it is not possible to separate an entire surgical block, we suggest designating specific rooms for the care of patients with COVID-19 that will not be used for regular cases. The gold standard test for investigation of the upper urinary tract is uro-tomography, but in times when we need to consider the use of resources, ultrasound could potentially be used since many imaging services are overloaded due to the frequent indication of thoracic CTs for the diagnosis and follow-up of patients with Sars-Cov-2. -In Intermediate-risk and high-risk non--muscle-invasive bladder cancers: Clinically fit patients with no major comorbidities should receive induction therapy followed by at least 1-year maintenance BCG. abstract: This letter to the Editor aims to provide suggestions and recommendations for the management of urological conditions in times of COVID-19 crisis in Brazil and other low- and middle-income countries. It is important to highlight that one of the main characteristics of this pandemic is the oversaturation of the health system capacity, mostly due to a high demand for personal protective equipment (PPE), Hospital/ICU beds, as well as ventilators. In places with limited resources and where the health care systems are already saturated, such consideration is even more worrisome. Therefore, most worldwide authorities are recommending to avoid, as much as possible, patient’s elective visits to hospitals, as well as a judicious use of the operating room in order to mitigate the strain put on the health system. While efforts should be directed to the care of COVID-19 patients, other conditions (especially urgencies and oncological cases) must continue to be assisted. Thus, through a panel of experts, we have prepared a practical guide for urologists based on the recommendations from the main Urologic Associations, as well as data from the literature to support the suggested management. We will try to follow the standard guideline recommendations from the American Urological Association (AUA) and European Association of Urology (EAU), with the aim of pursuing the best outcomes possible. However, some recommendations were based on the consensus of the panel, taking into consideration the reality of developing countries and the unprecedented situation caused by the COVID-19 crisis. url: https://doi.org/10.1590/s1677-5538.ibju.2020.04.03 doi: 10.1590/s1677-5538.ibju.2020.04.03 id: cord-010477-g754gjvh author: Carney, Kevin P. title: A Front-end Redesign With Implementation of a Novel “Intake” System to Improve Patient Flow in a Pediatric Emergency Department date: 2020-02-27 words: 3735.0 sentences: 210.0 pages: flesch: 52.0 cache: ./cache/cord-010477-g754gjvh.txt txt: ./txt/cord-010477-g754gjvh.txt summary: Key process elements included (1) new Flow Nurse/EMT roles, (2) elimination of traditional registration and triage processes, (3) immediate "quick registration" and nurse assessment upon walk-in, (4) direct-bedding of patients, and (5) a novel "Intake" system staffed by a pediatric emergency medicine physician. CONCLUSIONS: Using quality improvement and Lean methodology, an inter-professional team decreased door-to-provider times and LWBS rates in a large pediatric ED by redesigning its front-end processes and implementing a novel pediatric emergency medicine-led Intake system. Strategies employed to improve the front-end processes include the abolishment of traditional nurse-led triage, "split-flow" models that create separate patient streams depending on each individual''s particular care needs, direct-bedding of patients, and placing providers in triage. Using QI and Lean methodology, an inter-professional team in a large, tertiary-care pediatric ED designed and implemented a novel front-end system and significantly improved patient flow by decreasing door-to-provider times 49% and LWBS rates by over 50%. abstract: INTRODUCTION: Children’s Hospital Colorado is an academic, tertiary-care Level 1 Trauma Center with an emergency department (ED) that treats >70,000 patients/year. Patient volumes continue to increase, leading to worsening wait times and left-without-being-seen (LWBS) rates. In 2015, the ED’s median door-to-provider time was 49 minutes [interquartile range (IQR) = 26–90], with a 3.2% LWBS rate. ED leadership, staff, and providers aimed to improve patient flow with specific goals to (1) decrease door-to-provider times to a median of <30 minutes and (2) decrease annual LWBS rate to <1%. METHODS: An inter-professional team utilized quality improvement and Lean methodology to study, redesign, and implement significant changes to ED front-end processes. Key process elements included (1) new Flow Nurse/EMT roles, (2) elimination of traditional registration and triage processes, (3) immediate “quick registration” and nurse assessment upon walk-in, (4) direct-bedding of patients, and (5) a novel “Intake” system staffed by a pediatric emergency medicine physician. RESULTS: In the 12 months following full implementation of the new front-end system, the median door-to-provider time decreased 49% to 25 minutes (IQR = 13–50), and the LWBS rate decreased from 3.2% to 1.4% (a 56% relative decrease). Additionally, the percentage of patients seen within 30 minutes of arrival increased, overall ED length-of-stay decreased, patient satisfaction improved, and no worsening of the unexpected 72-hour return rate occurred. CONCLUSIONS: Using quality improvement and Lean methodology, an inter-professional team decreased door-to-provider times and LWBS rates in a large pediatric ED by redesigning its front-end processes and implementing a novel pediatric emergency medicine-led Intake system. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190261/ doi: 10.1097/pq9.0000000000000263 id: cord-265799-qda5awuc author: Carothers, Chancey title: Acetylcysteine for the Treatment of Suspected Remdesivir‐Associated Acute Liver Failure in COVID‐19: A Case Series date: 2020-10-02 words: 3152.0 sentences: 157.0 pages: flesch: 50.0 cache: ./cache/cord-265799-qda5awuc.txt txt: ./txt/cord-265799-qda5awuc.txt summary: We report two cases of suspected remdesivirassociated acute liver failure (ALF) in patients with COVID-19 in which the liver failure improved with the addition of continuous infusion acetylcysteine and discontinuation of potentially hepatotoxic medications. 10 The EUA fact sheet provided by the manufacturer states that in the original compassionate use program of remdesivir in patients with severe or critical illness with COVID-19, liver function test abnormalities were reported in 12% of patients with a time to onset from first dose ranging from 1-16 days. One published case report by Leegwater discusses a case of acute liver failure 5 days after initiation of remdesivir in a patient with severe COVID-19 pneumonia. The use of the novel antiviral remdesivir in the treatment of COVID-19 pneumonia may put patients at risk of drug-associated acute liver failure. abstract: Remdesivir is a direct‐acting nucleoside RNA polymerase inhibitor with activity against the novel SARS‐CoV‐2 virus used in the treatment of COVID‐19 pneumonia. Here we present two cases of suspected remdesivir‐associated acute liver failure (ALF) in which the liver failure improved following continuous infusion acetylcysteine and withdrawal of remdesivir. Both patients had significant increases in transaminases between day 3 and day 10 of remdesivir therapy accompanied by coagulopathy and encephalopathy. After initiation of continuous infusion acetylcysteine, the transaminases of both patients rapidly improved. Ultimately one patient fully recovered while the other died of suspected septic shock. Due to its novel nature and only recent widespread use, there is very little data on the risk of ALF from remdesivir. Additionally, the data for the use of acetylcysteine to manage non‐acetaminophen‐induced ALF is limited. It is important to consider the risk of remdesivir‐associated ALF when weighing the risk vs. benefits of use, and acetylcysteine may have a role in its management. url: https://www.ncbi.nlm.nih.gov/pubmed/33006138/ doi: 10.1002/phar.2464 id: cord-354372-vfvnjmv1 author: Carpenito, L. title: The autopsy at the time of SARS-CoV-2: Protocol and lessons date: 2020-07-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A new viral disease named COVID-19 has recently turned into a pandemic. Compared to a common viral pneumonia it may evolve in an atypical way, causing the rapid death of the patient. For over two centuries, autopsy has been recognized as a fundamental diagnostic technique, particularly for new or little-known diseases. To date, it is often considered obsolete giving the inadequacy to provide samples of a quality appropriate to the sophisticated diagnostic techniques available today. This is probably one of the reasons why during this pandemic autopsies were often requested only in few cases, late and discouraged, if not prohibited, by more than one nation. This is in contrast with our firm conviction: to understand the unknown we must look at it directly and with our own eyes. This has led us to implement an autopsy procedure that allows the beginning of the autopsy shortly after death (within 1–2 h) and its rapid execution, also including sampling for ultrastructural and molecular investigations. In our experience, the tissue sample collected for diagnosis and research were of quality similar to biopsy or surgical resections. This procedure was performed ensuring staff and environmental safety. We want to propose our experience, our main qualitative results and a few general considerations, hoping that they can be an incentive to use autopsy with a new procedure adjusted to match the diagnostic challenges of the third millennium. url: https://www.ncbi.nlm.nih.gov/pubmed/32653819/ doi: 10.1016/j.anndiagpath.2020.151562 id: cord-271920-1dzkgt6w author: Carpenter, Christopher R. title: Diagnosing COVID‐19 in the Emergency Department: A Scoping Review of Clinical Exam, Labs, Imaging Accuracy and Biases date: 2020-06-16 words: 7248.0 sentences: 523.0 pages: flesch: 48.0 cache: ./cache/cord-271920-1dzkgt6w.txt txt: ./txt/cord-271920-1dzkgt6w.txt summary: 3 As waves of COVID-19 patients present to ED''s in coming months with symptoms or potential exposures, understanding the diagnostic accuracy and reliability of history, physical exam, routine labs, advanced imaging, and an evolving array of COVID-19 diagnostics will be essential knowledge to inform the timing of testing, optimal specimen and test selection, shared decision-making, and ultimately derivation of clinical instruments to guide disposition, follow-up, and shared The search strategy used a combination of standardized terms and key words, including but not limited to (Covid-19 OR Novel Coronavirus OR SARS-COV-2) AND (diagnosis OR polymerase chain reaction OR serology OR CRISPR-CAS OR sensitivity/specificity) (Appendix). 40,42 It is known, however, that false negatives are frequent, so current recommendations advise incorporating patient''s exposure risk, clinical signs and symptoms, routine lab and imaging findings, serology, and (when available) CT results into real-time determination of COVID-19 status. abstract: In December 2019 a novel viral respiratory pathogen emerged in China, ultimately named severe acute respiratory syndrome coronavirus 2 (SARS‐Co‐V‐2) with the clinical illness dubbed coronavirus disease (COVID‐19). COVID‐19 became a global pandemic in early 2020 forcing governments worldwide to enact social isolation policies with dire economic ramifications. Emergency departments (ED) encountered decreased patient volumes before some in Seattle, New York City, New Orleans, and Detroit experienced waves of COVID‐19 patients mixed with asymptomatic patients or those concerned about potential exposures. Diagnosing COVID‐19 was hampered by inadequate supplies of reagents and kits, which was compounded by clinical and radiographic features that overlap with numerous seasonal viral respiratory infections. url: https://doi.org/10.1111/acem.14048 doi: 10.1111/acem.14048 id: cord-031129-wqkdug42 author: Carr, Zyad J. title: An Update on Systemic Sclerosis and its Perioperative Management date: 2020-08-29 words: 4637.0 sentences: 232.0 pages: flesch: 27.0 cache: ./cache/cord-031129-wqkdug42.txt txt: ./txt/cord-031129-wqkdug42.txt summary: RECENT FINDINGS: Evidence shows that patients with SSc demonstrate an increased risk for perioperative myocardial infarction, high rates of interstitial lung disease, pulmonary arterial hypertension, neurological disease, gastric dysmotility disorders, and challenging airway management, all findings that may result in suboptimal perioperative outcomes. Optimal perioperative management and risk stratification should expand beyond the well-described airway challenges and consider numerous systemic manifestations of systemic sclerosis such as pulmonary arterial hypertension, interstitial lung disease, and cardiac sequelae. Separately, pulmonary hypertension related to ILD or SScrelated cardiac involvement may increase both morbidity and mortality in the perioperative period and may be present in 8-12% of SSC patients [23, 25•] . Microstomia is likely a prominent physical feature of challenging airway management in the patient with SSc supported by a meta-analysis of 15 studies that examined risk factors for intensive care unit-related mortality in a mixed ILD population and found a strong correlation between mortality and the application of invasive mechanical ventilation [69] . abstract: PURPOSE OF REVIEW: Systemic sclerosis or scleroderma (SSc) is a systemic, immune-mediated disease characterized by abnormal cutaneous and organ-based fibrosis that results in progressive end-organ dysfunction and decreased survival. SSc results in significant challenges for the practicing anesthesiologist due to its rarity, multi-system involvement, and limited evidence-based guidance for optimal perioperative care. In this update, we briefly discuss the recent evidence on the pathophysiology and current management of SSc, review the anesthesia-related literature, and extrapolate these observations into an optimal perioperative strategy for the care of SSc patients. RECENT FINDINGS: Evidence shows that patients with SSc demonstrate an increased risk for perioperative myocardial infarction, high rates of interstitial lung disease, pulmonary arterial hypertension, neurological disease, gastric dysmotility disorders, and challenging airway management, all findings that may result in suboptimal perioperative outcomes. SUMMARY: Advances in SSc medical management have resulted in improved survival, likely increasing the number of patients who will be exposed to perioperative care. Optimal perioperative management and risk stratification should expand beyond the well-described airway challenges and consider numerous systemic manifestations of systemic sclerosis such as pulmonary arterial hypertension, interstitial lung disease, and cardiac sequelae. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455511/ doi: 10.1007/s40140-020-00411-8 id: cord-284042-awl5bb0j author: Carrascosa, J.M. title: Cutaneous Manifestations in the Context of SARS-CoV-2 Infection (COVID-19)() date: 2020-10-15 words: 3952.0 sentences: 216.0 pages: flesch: 45.0 cache: ./cache/cord-284042-awl5bb0j.txt txt: ./txt/cord-284042-awl5bb0j.txt summary: From the pathogenic point of view, the immune response triggered by infection with SARS-CoV-2 may result in harmful effects, such as endothelial cell dysfunction and activation of J o u r n a l P r e -p r o o f coagulation pathways; this may explain the cardiovascular and thrombotic complications that affect a subgroup of patients. 19 Vesicular lesions, usually monomorphic, appear early on and may at times precede other symptoms (in 15% of patients), 11 although in most cases, up to 79.2% in a series of 24 patents reported by Fernandez-Nieto et al., 20 they occur at the onset of other symptoms. 21 reported the case of a female patient who developed an urticarial rash, accompanied by odynophagia and arthralgia, before developing the full clinical manifestations of COVID-19. abstract: The coronavirus 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had enormous health, economic, and social consequences. The clinical spectrum of cutaneous manifestations observed in patients with COVID-19 is both heterogeneous and complex. To date, reports have identified 5 main categories: acral lesions, vesicular rashes, urticarial rashes, maculopapular rashes, and livedoid and necrotic lesions. However, these will probably be modified as new information comes to light. Cutaneous manifestations associated with COVID-19 probably reflect the activation of pathogenic pathways by the virus or a response to inflammatory processes, vascular or systemic complications, or even treatments. Familiarity with the cutaneous manifestations of COVID-19 may enable early diagnosis or help guide prognosis. url: https://api.elsevier.com/content/article/pii/S1578219020302754 doi: 10.1016/j.adengl.2020.10.001 id: cord-330666-puhijixa author: Carrico, Ruth M. title: Changing health care worker behavior in relation to respiratory disease transmission with a novel training approach that uses biosimulation date: 2007-02-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: This pilot study was conducted to determine whether supplementing standard classroom training methods regarding respiratory disease transmission with a visual demonstration could improve the use of personal protective equipment among emergency department nurses. METHODS: Participants included 20 emergency department registered nurses randomized into 2 groups: control and intervention. The intervention group received supplemental training using the visual demonstration of respiratory particle dispersion. Both groups were then observed throughout their work shifts as they provided care during January-March 2005. RESULTS: Participants who received supplemental visual training correctly utilized personal protective equipment statistically more often than did participants who received only the standard classroom training. CONCLUSION: Supplementing the standard training methods with a visual demonstration can improve the use of personal protective equipment during care of patients exhibiting respiratory symptoms. url: https://www.ncbi.nlm.nih.gov/pubmed/17276786/ doi: 10.1016/j.ajic.2005.12.013 id: cord-292345-zc209dfx author: Carroll, Elizabeth title: Catastrophic Intracranial Hemorrhage in Two Critically Ill Patients with COVID-19 date: 2020-05-26 words: 1580.0 sentences: 90.0 pages: flesch: 51.0 cache: ./cache/cord-292345-zc209dfx.txt txt: ./txt/cord-292345-zc209dfx.txt summary: Although it has been noted that COVID-19 may increase risk for acute cerebrovascular events, including both ischemic and hemorrhagic stroke [2] , to our knowledge, this is the first report of patients with COVID-19 who had catastrophic intracranial hemorrhages. To address this, Thachil noted that use of anticoagulation in patients with elevated D-dimers may decrease mortality by both preventing thrombi and dampening the inflammatory response triggered by COVID-19 [7] . Thus, at our center, it was decided that therapeutic anticoagulation should be initiated empirically for patients with COVID-19 who have a D-dimer > 10,000 ng/ mL and considered for patients who have a D-dimer between 2000 and < 10,000 ng/mL using treatment dose enoxaparin or heparin titrated to a low therapeutic anti-Xa goal of 0.3-0.5 U/mL. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32458333/ doi: 10.1007/s12028-020-00993-5 id: cord-279396-qmixem8i author: Carter, Chris title: COVID-19 Disease: a critical care perspective date: 2020-06-01 words: 5302.0 sentences: 288.0 pages: flesch: 49.0 cache: ./cache/cord-279396-qmixem8i.txt txt: ./txt/cord-279396-qmixem8i.txt summary: In addition to the relatively high numbers of COVID-19 patients developing severe respiratory failure resulting in acute respiratory distress syndrome (ARDS) and requiring intubation and ventilatory support, the current data suggests an average length of stay for COVID patients in intensive care of eight days. The critical care nurse needs to recognise that patients who develop severe COVID-19 can rapidly develop Type 1 Respiratory Failure, ARDS and therefore require ventilatory support. 18 In non COVID-19 patients with increasing respiratory failure the use of High Flow Nasal Oxygen (HFNO) or Non-Invasive Ventilation (NIV) such as Continuous Positive Airway Pressure (CPAP) may be used as a treatment strategy. 40 There is also a suggestion that an increased number of healthcare professionals is needed when providing care, particularly in critical care for procedures requiring two nurses to one patient (2:1) when PPE is worn. abstract: Abstract COVID-19 is a new highly infectious disease with an incompletely described clinical course, which has caused a pandemic, with Europe being identified as the third epicentre. COVID-19 has placed unprecedented pressure on critical care services which is likely to stretch resources beyond capacity. The situation is exacerbated by increased staff absence from self-isolation and illness, increased referral of patients with suspected or confirmed COVID-19 who develop respiratory failure, and limited availability of Extra Corporeal Membrane Oxygenation (ECMO) services. In addition, there is the ongoing challenge of patients being transferred between departments and hospitals for ongoing care. In consequence, as current needs continue to rise, innovative approaches are needed to redress shortages and support the continuance of services. This article provides an overview of severe COVID-19 infection, outlining treatment strategies and nursing processes that will need to develop and extend in response to this evolving situation. url: https://www.sciencedirect.com/science/article/pii/S2666869620300038?v=s5 doi: 10.1016/j.intcar.2020.100003 id: cord-312847-2cg3ylfl author: Carter, Chris title: COVID-19 Disease: assessment of a critically ill patient date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract With the major scale up of critical care services to respond to the increasing numbers of patients with severe COVID-19 infection, nurses need to be able to rapidly assess patients. While many patients present with signs of viral pneumonia and may develop respiratory failure, it is essential that the subsequent systemic complications are also recognized. Due to the unprecedented numbers of patients requiring critical care, many of them will initially have to be managed in the emergency departments and acute wards until a critical care bed becomes available. In this article, the assessment of a patient with suspected or confirmed severe COVID-19 has been presented initially from a ward perspective, followed by that of critical care, using the Airway, Breathing, Circulation, Disability and Exposure (ABCDE) approach. This article has been specifically designed to enable nurses to systematically assess patients and prioritise care. url: https://www.sciencedirect.com/science/article/pii/S2666869620300014?v=s5 doi: 10.1016/j.intcar.2020.100001 id: cord-329215-awxfetdj author: Carter, Chris title: COVID-19 Disease: invasive ventilation date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract This article focuses on the critical care nurse’s role in the management of patients with COVID-19 who require invasive ventilation in order to improve outcomes and prevent complications. The nature of COVID-19 is such that many patients deteriorate rapidly and for members of this group requiring intubation and invasive ventilation, different approaches to airway management and ventilatory support are required. In order to reduce the risk of complications and an overview of invasive ventilation, including commonly used modes, potential complications, nursing care, weaning and extubation are all described. COVID-19 presents several challenges as the disease progresses, hypoxemia may worsen, and the patient can develop Acute Respiratory Distress Syndrome. Therefore, additional treatment strategies including the use of the prone position and the use of nitric oxide and prostacyclin nebulisers have been included. The strategies presented in this article are relevant to both critical care nurses and those re-deployed to intensive care units where nurses will inevitably be involved in the management of patients requiring invasive ventilation. Weaning these patients off invasive ventilation is multi-factorial and may be short or long term. A multi-disciplinary weaning plan, the principles, stages/phases, and speed of weaning with expected parameters prior extubation are explained. Planned and unplanned extubation with the serious complications of the latter as the patient may not be ready and may require emergency re-intubation resulting in setbacks should be avoided. url: https://www.sciencedirect.com/science/article/pii/S266686962030004X?v=s5 doi: 10.1016/j.intcar.2020.100004 id: cord-010460-pczs9alv author: Caruso, Thomas J. title: Retrospective Review of the Safety and Efficacy of Virtual Reality in a Pediatric Hospital date: 2020-04-10 words: 3801.0 sentences: 200.0 pages: flesch: 43.0 cache: ./cache/cord-010460-pczs9alv.txt txt: ./txt/cord-010460-pczs9alv.txt summary: Secondary objectives were to characterize the efficacy of VR in enhancing patient cooperation, describe the integration of VR into Child Life services, and identify interventions that accompanied VR. Secondary objectives of the study were to analyze VR efficacy in enhancing patient cooperation, describe the integration of VR into Child Life services throughout a pediatric hospital, and identify the frequency with which CCLS paired other interventions with VR. The Chariot Program and CCLS collaborated with the hospital information services (IS) department to develop customized child life intervention notes in the EMR. CCLS also documented which coping interventions the patient underwent, including family presence, comfort positioning, diaphragmatic breathing, environmental adaptions, imagery, pharmacologic assistance, tablet, bedside entertainment theater, 25 VR, augmented reality, interactive video game, and/or movie. In the exploratory VR analysis, patients were more likely to be cooperative after receiving a VR coping intervention (with or without accompanying interventions) (99.5%, n = 212, 95% CI 97.4%-100%) compared to preintervention (96.7%, n = 206, 95% CI 93.4%-98.4%, P = 0.041). abstract: INTRODUCTION: Virtual reality (VR) is an emerging tool for anxiety and fear reduction in pediatric patients. VR use is facilitated by Certified Child Life Specialists (CCLS) at pediatric hospitals. The primary aim of this study was to retrospectively review the safety of VR by analyzing adverse events after the utilization of VR under CCLS supervision. Secondary objectives were to characterize the efficacy of VR in enhancing patient cooperation, describe the integration of VR into Child Life services, and identify interventions that accompanied VR. METHODS: The Stanford Chariot Program developed VR applications, customized VR interfaces, and patient head straps, and distributed these to CCLS. Chart review analyzed VR utilization through CCLS patient notes. Inclusion criteria were all patients ages 6 to 18-years-old who received a Child Life intervention. RESULTS: From June 2017 to July 2018, 31 CCLS saw 8,098 patients, 3,696 of which met age criteria with pre- and post-intervention cooperation data. Two hundred thirteen patients received VR with an accompanying intervention, while 34 patients received only VR. Adverse events were rare, and included increased anxiety (3.8%, n=8), dizziness (0.5%, n=1), and nausea (0.5%, n=1). Patients were more likely to be cooperative after receiving VR (99.5%, n=212) compared to pre-intervention (96.7%, n=206, p=0.041). VR use was most common in the perioperative setting (60%, n=128), followed by outpatient clinics (15%, n=32). CONCLUSION: VR is safe in pediatric patients with appropriate hardware, software, and patient selection. Side effects were rare and self-limited. VR appears to be associated with improvements in cooperation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190243/ doi: 10.1097/pq9.0000000000000293 id: cord-354597-xubsodnk author: Carvalho, Alexandre title: SARS-CoV-2 Gastrointestinal Infection Causing Hemorrhagic Colitis: Implications for Detection and Transmission of COVID-19 Disease date: 2020-04-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32496741/ doi: 10.14309/ajg.0000000000000667 id: cord-018363-qr1pk78u author: Casey, Ashley title: Consultative and Comanagement date: 2015-10-10 words: 19168.0 sentences: 1810.0 pages: flesch: 60.0 cache: ./cache/cord-018363-qr1pk78u.txt txt: ./txt/cord-018363-qr1pk78u.txt summary: Results of physical examination are as follows: temperature, 38.9 °C (102.1 °F); heart rate, 116 bpm; blood pressure, 96/60 mmHg; respiratory rate, 35 breaths/min; and O 2 saturation, 74 % on 100 % O 2 with a nonrebreather mask. In the past 20 min, the patient has become abruptly short of breath, hypoxic, and severely hypotensive with a blood pressure of 72/palpation mm Hg. On physical exam, she is obtunded and in serve respiratory distress. A 64-year-old female with a past medical history signifi cant for type 2 diabetes mellitus is admitted with increasing shortness of breath. A meta-analysis of 15 studies reports that hyperglycemia increased both in-hospital mortality and incidence of heart failure in patients admitted for acute myocardial infarction. Continuing warfarin treatment at the time of pacemaker in patients with high thrombotic risk was associated with a lower incidence of clinically signifi cant device-pocket hematoma, as opposed to bridging with heparin. abstract: This chapter covers the role of the hospitalist as a consultant and their interaction with surgical specialties. Included are discussions of perioperative care in the hospital and clinic. Oral and parenteral nutrition for the hospitalized patient are examined. A special emphasis is placed on palliative care for the hospitalized patient. Comanagement of surgical patients with an emphasis on orthopedics is reviewed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123218/ doi: 10.1007/978-3-319-23748-0_2 id: cord-341314-1mav631s author: Caso, Valeria title: No lockdown for neurological diseases during COVID19 pandemic infection date: 2020-04-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32270358/ doi: 10.1007/s10072-020-04389-3 id: cord-262824-xgf5v1ok author: Castillo, Felipe title: On Redeployment to Palliative Care date: 2020-11-10 words: 1135.0 sentences: 59.0 pages: flesch: 56.0 cache: ./cache/cord-262824-xgf5v1ok.txt txt: ./txt/cord-262824-xgf5v1ok.txt summary: I bore witness to this conflict play out when I transitioned from the role of researcher working on the national opioid overdose epidemic to the front lines of the pandemic, providing palliative care. I paused my own training in addiction psychiatry to join the palliative care service, as we needed physicians capable of supporting patients and their families and conducting conversations to elicit goals of care in the emergency rooms and ICUs. My tasks turned out to be much more than that: I assisted in repositioning patients into the prone recovery position, held an iPad at the bedside for last goodbyes, and grieved deaths with primary teams. Interpreting at the end of life: a systematic review of the impact of interpreters on the delivery of palliative care services to cancer patients with limited English proficiency abstract: nan url: https://doi.org/10.1007/s40596-020-01355-1 doi: 10.1007/s40596-020-01355-1 id: cord-346558-u1e0kzmm author: Cattaruzza, Maria Sofia title: Tobacco smoking and COVID-19 pandemic: old and new issues. A summary of the evidence from the scientific literature date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: COVID-19 pandemic burst onto the international scene as a new disease disproportionately affecting certain patient groups; hence it has risen many questions yet to be clarified. The aim of this study was to outline the main issues that led tobacco smoking being discussed as a potential risk factor associated with COVID-19. METHODS: articles from MEDLINE and pre-prints published from January to April 2020 were identified. RESULTS: data from China showed that men had more severe outcomes of COVID-19 than women. Since smoking prevalence is very high among Chinese men in comparison to women, it was hypothesized that smoking could be a risk factor for poor prognosis. This was also supported by the higher prevalence of comorbidities, many of which tobacco-related diseases, in patients with severe COVID-19, who were also more likely to have a smoking history. A meta-analysis confirmed these results, reporting an OR=2.25 (95% CI: 1.49-3.39) for developing severe COVID-19 among patients with a smoking history. Some authors, noticing that reported smoking prevalence among hospitalized patients was substantially lower than smoking prevalence in the source populations, speculated a protective role of nicotine. However, it is likely that low prevalence among hospitalized patients are partially due to many smokers misclassified as nonsmokers. Tobacco smoking seems to cause a dose-dependent upregulation of angiotensin-converting-enzyme-2 (ACE2), the virus cellular entry receptor, which could explain the higher risk of severe COVID-19 in smokers. CONCLUSIONS: There is need for further independent studies to clarify the role of smoking on COVID-19 incidence, progression and mortality. (www.actabiomedica.it) url: https://doi.org/10.23750/abm.v91i2.9624 doi: 10.23750/abm.v91i2.9624 id: cord-001293-dfaxj3bv author: Cavaillon, Jean-Marc title: Is boosting the immune system in sepsis appropriate? date: 2014-03-24 words: 6238.0 sentences: 315.0 pages: flesch: 33.0 cache: ./cache/cord-001293-dfaxj3bv.txt txt: ./txt/cord-001293-dfaxj3bv.txt summary: In response to the failure of therapies aiming to target either the up-stream microbial activators or the effector molecules of the inflammatory cascade, a new concept has emerged of boosting the immune system to counter immunosuppression that develops in patients who survive the initial, hyperinflammatory period of sepsis [1] . One can conjecture that systemic treatment with IL-7 may act in undesired places, as illustrated by the following: IL-7 worsens graft-versus-host-induced tissue inflammation [81] ; favors inflammation in colitis [82] , contributes to arthritis severity [83] ; upregulates chemokines, IFNγ, macrophage recruitment, and lung inflammation [84] ; and, finally, increases production of inflammatory cytokines by monocytes and T cells [85] . Not only are PD-1-deficient mice markedly protected from the lethality of sepsis, accompanied by a decreased bacterial burden and suppressed inflammatory cytokine response [98] , but also blockade of PD-1 or PD-L1 improves survival in a murine model of sepsis, reverses immune dysfunction, inhibits lymphocyte apoptosis, and attenuates organ dysfunction [99] [100] [101] . abstract: A relative immunosuppression is observed in patients after sepsis, trauma, burns, or any severe insults. It is currently proposed that selected patients will benefit from treatment aimed at boosting their immune systems. However, the host immune response needs to be considered in context with pathogen-type, timing, and mainly tissue specificity. Indeed, the immune status of leukocytes is not universally decreased and their activated status in tissues contributes to organ failure. Accordingly, any new immune-stimulatory therapeutic intervention should take into consideration potentially deleterious effects in some situations. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035855/ doi: 10.1186/cc13787 id: cord-345611-xv62h83a author: Cavalcanti, A. B. title: Hydroxychloroquine alone or in combination with azithromycin to prevent major clinical events in hospitalised patients with coronavirus infection (COVID-19): rationale and design of a randomised, controlled clinical trial date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction: Hydroxychloroquine and its combination with azithromycin have been suggested to improve viral clearance in patients with COVID-19, but its effect on clinical outcomes remains uncertain. Methods and analysis: We describe the rationale and design of an open-label pragmatic multicentre randomised (concealed) clinical trial of 7 days of hydroxychloroquine (400 mg BID) plus azithromycin (500 mg once daily), hydroxychloroquine 400 mg BID, or standard of care for moderately severe hospitalised patients with suspected or confirmed COVID-19 (in-patients with up to 4L/minute oxygen supply through nasal catheter). Patients are randomised in around 50 recruiting sites and we plan to enrol 630 patients with COVID-19. The primary endpoint is a 7-level ordinal scale measured at 15-days: 1)not hospitalised, without limitations on activities; 2)not hospitalised, with limitations on activities; 3)hospitalised, not using supplementary oxygen; 4)hospitalised, using supplementary oxygen; 5)hospitalised, using high-flow nasal cannula or non-invasive ventilation; 6)hospitalised, on mechanical ventilation; 7)death. Secondary endpoints are the ordinal scale at 7 days, need for mechanical ventilation and rescue therapies during 15 days, need of high-flow nasal cannula or non-invasive ventilation during 15 days, length of hospital stay, in-hospital mortality, thromboembolic events, occurrence of acute kidney injury, and number of days free of respiratory support at 15 days. Secondary safety outcomes include prolongation of QT interval on electrocardiogram, ventricular arrhythmias, and liver toxicity. The main analysis will consider all patients with confirmed COVID-19 in the groups they were randomly assigned. Ethics and dissemination: This study has been approved by Brazil's National Ethic Committee (CONEP) and National Health Surveillance Agency (ANVISA). An independent data monitoring committee will perform interim analyses and evaluate adverse events throughout the trial. Results will be submitted for publication after enrolment and follow-up are complete, as well as presented and reported to local health agencies. ClinicalTrials.gov identifier: NCT04322123 url: https://doi.org/10.1101/2020.05.19.20106997 doi: 10.1101/2020.05.19.20106997 id: cord-336543-ydrmlujj author: Cavalli, Eugenio title: Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review) date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel β coronavirus that is the etiological agent of the pandemic coronavirus disease 2019 (COVID-19) that at the time of writing (June 16, 2020) has infected almost 6 million people with some 450,000 deaths. These numbers are still rising daily. Most (some 80%) cases of COVID-19 infection are asymptomatic, a substantial number of cases (15%) require hospitalization and an additional fraction of patients (5%) need recovery in intensive care units. Mortality for COVID-19 infection appears to occur globally between 0.1 and 0.5% of infected patients although the frequency of lethality is significantly augmented in the elderly and in patients with other comorbidities. The development of acute respiratory distress syndrome and episodes of thromboembolism that may lead to disseminated intravascular coagulation (DIC) represent the primary causes of lethality during COVID-19 infection. Increasing evidence suggests that thrombotic diathesis is due to multiple derangements of the coagulation system including marked elevation of D-dimer that correlate negatively with survival. We propose here that the thromboembolic events and eventually the development of DIC provoked by SARS-CoV-2 infection may represent a secondary anti-phospholipid antibody syndrome (APS). We will apply both Baconian inductivism and Cartesian deductivism to prove that secondary APS is likely responsible for coagulopathy during the course of COVID-19 infection. Diagnostic and therapeutic implications of this are also discussed. url: https://www.ncbi.nlm.nih.gov/pubmed/32588061/ doi: 10.3892/ijmm.2020.4659 id: cord-302177-8w3ojgd4 author: Cavayas, Yiorgos Alexandros title: Early experience with critically ill patients with COVID-19 in Montreal date: 2020-09-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Montreal has been the epicentre of the coronavirus disease (COVID-19) pandemic in Canada. Given the regional disparities in incidence and mortality in the general population, we aimed to describe local characteristics, treatments, and outcomes of critically ill COVID-19 patients in Montreal. METHODS: A single-centre retrospective cohort of consecutive adult patients admitted to the intensive care unit (ICU) of Hôpital du Sacré-Coeur de Montréal with confirmed COVID-19 were included. RESULTS: Between 20 March and 13 May 2020, 75 patients were admitted, with a median [interquartile range (IQR)] age of 62 [53–72] yr and high rates of obesity (47%), hypertension (67%), and diabetes (37%). Healthcare-related infections were responsible for 35% of cases. The median [IQR] day 1 sequential organ failure assessment score was 6 [3–7]. Invasive mechanical ventilation (IMV) was used in 57% of patients for a median [IQR] of 11 [5–22] days. Patients receiving IMV were characterized by a moderately decreased median [IQR] partial pressure of oxygen:fraction of inspired oxygen (day 1 PaO(2):F(i)O(2) = 177 [138–276]; day 10 = 173 [147–227]) and compliance (day 1 = 48 [38–58] mL/cmH(2)O; day 10 = 34 [28–42] mL/cmH(2)O) and very elevated estimated dead space fraction (day 1 = 0.60 [0.53–0.67]; day 10 = 0.72 [0.69–0.79]). Overall hospital mortality was 25%, and 21% in the IMV patients. Mortality was 82% in patients ≥ 80 yr old. CONCLUSIONS: Characteristics and outcomes of critically ill patients with COVID-19 in Montreal were similar to those reported in the existing literature. We found an increased physiologic dead space, supporting the hypothesis that pulmonary vascular injury may be central to COVID-19-induced lung damage. url: https://doi.org/10.1007/s12630-020-01816-z doi: 10.1007/s12630-020-01816-z id: cord-322439-86dojc70 author: Celarier, Thomas title: Covid-19: Adapting the geriatric organisations to respond to the pandemic date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.resmer.2020.100774 doi: 10.1016/j.resmer.2020.100774 id: cord-341076-ox2ckhqu author: Cenzato, Marco title: Editorial. Neurosurgery in the storm of COVID-19: suggestions from the Lombardy region, Italy (ex malo bonum) date: 2020-04-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32276261/ doi: 10.3171/2020.3.jns20960 id: cord-323463-osf6t7cw author: Cercenado, Emilia title: Update on bacterial pathogens: virulence and resistance date: 2008-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The present article is an update of the literature on bacterial pathogens. Recognizing the interest and scientific and public health importance of infections produced by bacterial pathogens with new virulence mechanisms and/or new mechanisms of resistance to antimicrobial agents, a multidisciplinary group of Spanish physicians and microbiologists organized a joint session and revised the most important papers produced in the field during 2006. Each article was analyzed and discussed by one of the members of the panel. This paper focus on a variety of diseases that pose major clinical and public health challenges today; and include infections produced by community-acquired methicillin-resistant Staphylococcus aureus and S. aureus small colony variants, infections produced by multiply resistant coagulase-negative staphylococci, pneumococcal infections, human listeriosis, meningococcal disease, Haemophilus influenzae, pertussis, Escherichia coli, ESBL-producing organisms, and infections due to non-fermenters. After a review of the state of the art, papers selected in this field are discussed. url: https://www.sciencedirect.com/science/article/pii/S0213005X0876378X doi: 10.1016/s0213-005x(08)76378-x id: cord-309735-bwa1zo07 author: Cerfolio, Robert J. title: Many Ways to Skin A Cat date: 2020-07-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0003497520311760?v=s5 doi: 10.1016/j.athoracsur.2020.07.006 id: cord-302997-39o08tt1 author: Ceruti, S. title: Reduced mortality and shorten ICU stay in SARS-COV-2 pneumonia: a low PEEP strategy date: 2020-05-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background Intensive Care Unit (ICU) management of COVID-19 patients with severe hypoxemia is associated with high mortality. We implemented a "care map", as a standardized multidisciplinary approach to improve patients monitoring using: uniform patient selection for ICU admission, a low-PEEP strategy and a pharmacologic strategic thromboembolism management. Methods A standardized protocol for managing COVID-19 patients and ICU admissions was implemented through accurate Early Warning Score (EWS) monitoring and thromboembolism prophylaxis at hospital admission. Dyspnea, mental confusion or SpO2 less than 85% were criteria for ICU admission. Ventilation approach employed low PEEP values (about 10 cmH2O in presence of lung compliance > 40 mL/cmH2O) and FiO2 as needed. In presence of lower lung compliance (< 40 mL/cmH2O) PEEP value was increased to about 14 cmH2O. Results From March 16th to April 12nd 2020, 41 COVID-19 patients were admitted to our ICU from a total of 310 patients. 83% (34) of them needed mechanical ventilation. The ventilation approach chosen employed low PEEP value based on BMI (PEEP 11+/- 3.8 (10-12) cmH2O if BMI < 30 Kg/m2; PEEP 15+/- 3.26 (12-18) cmH2O if BMI >30 Kg/m2). To date, ten patients (24%) died, four (9.7%) received mechanical ventilation, two were transferred to another hospital and 25 (60.9%) were discharged from ICU after a median of nine days. Discussion A multimodal approach for COVID-19 patients is mandatory. The knowledge of this multi-organ disease is growing rapidly, requiring improvements in the standard of care. Our approach implements an accurate pre-ICU monitoring and strict selection for ICU admission, and allows to reduce mechanical ventilation, ICU stay and mortality. Funding No funding has been required. url: https://doi.org/10.1101/2020.05.03.20089318 doi: 10.1101/2020.05.03.20089318 id: cord-356057-87kxlqdc author: Chagas, Aline Lopes title: Management of Hepatocellular Carcinoma during the COVID-19 Pandemic - São Paulo Clínicas Liver Cancer Group Multidisciplinary Consensus Statement date: 2020-10-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: More than 18 million people in 188 countries have been diagnosed as having coronavirus disease (COVID-19), and COVID-19 has been responsible for more than 600,000 deaths worldwide. Brazil is now the second most affected country globally. Faced with this scenario, various public health measures and changes in the daily routines of hospitals were implemented to stop the pandemic. Patients with hepatocellular carcinoma (HCC) are at an increased risk for severe COVID-19 as they present with two major diseases: cancer and concomitant chronic liver disease. The COVID-19 pandemic can significantly impact the management of HCC patients from diagnosis to treatment strategies. These patients need special attention and assistance at this time, especially since treatment for tumors cannot be delayed in most cases. The aim of this guideline was to standardize the management of HCC patients during the COVID-19 pandemic. This document was developed, on the basis of the best evidence available, by a multidisciplinary team from Instituto do Câncer do Estado de São Paulo (ICESP), and Instituto Central of the Hospital das Clínicas da Universidade de São Paulo (HC-FMUSP), which are members of the São Paulo Clínicas Liver Cancer Group. url: https://www.ncbi.nlm.nih.gov/pubmed/33146360/ doi: 10.6061/clinics/2020/e2192 id: cord-319400-lghjiw5p author: Chaix, B. title: Psychological Distress during the COVID-19 pandemic in France: a national assessment of at-risk populations date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction More than 2.5 billion people in the world are currently in lockdowns to limit the spread of the novel coronavirus disease 2019 (COVID-19). Psychological Distress (PD) and Post-Traumatic Stress Disorder have been reported after traumatic events, but the specific effect of pandemics is not well known. The aim of this study was to assess PD in France, a country where COVID-19 had such a dramatic impact that it required a country-wide lockdown. Patients and methods We recruited patients in 4 groups of chatbot users followed for breast cancer, asthma, depression and migraine. We used the Psychological Distress Index (PDI), a validated scale to measure PD during traumatic events, and correlated PD risk with patients characteristics in order to better identify the one who were the most at-risk. Results The study included 1771 participants. 91.25% (1616) were female with a mean age of 32.8 years (SD=13,71), 7.96% (141) were male with a mean age of 28.0 years (SD=8,14). In total, 38.06% (674) of the respondents had psychological distress (PDI [≥]15). An ANOVA analysis showed that sex (p=0.00132), unemployment (p=7.16x10-6) and depression (p=7.49x10-7) were significantly associated with a higher PDI score. Patients using their smartphone or computer more than one hour a day also had a higher PDI score (p=0.02588). Conclusion Prevalence of PD in at-risk patients is high. These patients are also at increased risk to develop Post-Traumatic Stress Disorder. Specific steps should be implemented to monitor and prevent PD through dedicated mental health policies if we want to limit the public health impact of COVID-19 in time. url: https://doi.org/10.1101/2020.05.10.20093161 doi: 10.1101/2020.05.10.20093161 id: cord-327720-m6cofbj6 author: Chakrabarti, Amitabha title: Understanding the practice of thoracic surgery during the COVID-19 pandemic date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has affected the entire medical community including the thoracic surgical practice. The guidelines, consensus statements, and preliminary recommendations published by the thoracic surgeons so far have appreciated the importance of triage of patients with thoracic surgical diseases and multidisciplinary team (MDT) meeting. Delaying surgery or planning alternative treatment in patient care should be done by taking input from experts in thoracic specialties. The procedures that can be carried out in a hospital are based on the prevalence of COVID-19 patients within the hospital and availability of hospital resources. As a result, proper triaging, ensuring safety of patient and health care personnel, and optimal utilization of the available resources remain the cornerstone while fighting the COVID-19 pandemic. In this manuscript, we highlight these issues with respect to practice of thoracic surgery. url: https://www.ncbi.nlm.nih.gov/pubmed/32837046/ doi: 10.1007/s12055-020-01025-9 id: cord-255652-3n2dxljj author: Challener, Douglas W. title: Screening for COVID-19: Patient factors predicting positive PCR test date: 2020-05-19 words: 1162.0 sentences: 67.0 pages: flesch: 50.0 cache: ./cache/cord-255652-3n2dxljj.txt txt: ./txt/cord-255652-3n2dxljj.txt summary: title: Screening for COVID-19: Patient factors predicting positive PCR test SARS-CoV-2, the novel coronavirus causing COVID-19, was isolated in patients from Wuhan, China, in December 2019 and sparked a global pandemic in early 2020. At the Mayo Clinic in Rochester, Minnesota, we began screening patients for COVID-19 on a large scale on March 12, 2020, after Minnesota''s first case was reported on March 10, 2020. The COVID-19-negative patients were selected in a random fashion by matching age (±5 years), sex, collection date, and testing location (Minnesota, Wisconsin, or Arizona) with the positive patients. This study investigates the results of testing ambulatory patients in a relatively low prevalence area in early March 2020 and suggests that exposure to the disease is more predictive of a positive test than any examined symptom. In this analysis, exposure to confirmed SARS-CoV-2 and recent travel were both significantly more predictive of a positive test than the presence of any symptoms. abstract: To inform the efficient allocation of testing resources, we evaluated the characteristics of those tested for COVID-19 to determine predictors of a positive test. Recent travel and exposure to a confirmed case were both highly predictive of positive testing. Symptom-based screening strategies alone may be inadequate to control the ongoing pandemic. url: https://doi.org/10.1017/ice.2020.249 doi: 10.1017/ice.2020.249 id: cord-283682-4fcyoyea author: Chan, Edward D. title: Mycoplasma pneumoniae-Associated Bronchiolitis Causing Severe Restrictive Lung Disease in Adults Report of Three Cases and Literature Review date: 1999-04-30 words: 3963.0 sentences: 256.0 pages: flesch: 37.0 cache: ./cache/cord-283682-4fcyoyea.txt txt: ./txt/cord-283682-4fcyoyea.txt summary: title: Mycoplasma pneumoniae-Associated Bronchiolitis Causing Severe Restrictive Lung Disease in Adults Report of Three Cases and Literature Review There were two with respiratory bronchiolitis, one with panbronchiolitis, one patient with bronchiolitis obliterans organizing pneumonia (BOOP), and six with acute inflammatory bronchiolitis. Conclusions In adults, Mycoplasma-associated bronchiolitis without pneumonia is rarely reported, but in hospitalized patients, it may be more common than expected and may be associated with severe physiologic disturbances. In another patient, an acute obstructive defect with hyperinflation, a diffuse and fine granular pattern on chest radiograph, and a cold agglutinin titer of 1:1,024 were found, consistent with constrictive bronchiolitis due to either a viral or Mycoplasma infection. Fraley et al 12 described a patient with respiratory failure from M pneumoniae pneumonia who had both acute necrotizing pneumonitis with consolidation and "bronchiolitis obliterans" on open lung biopsy specimen. abstract: Study objectives To characterize adult Mycoplasma pneumoniae-induced bronchiolitis requiring hospitalization. Design We encountered an adult patient with severe bronchiolitis in the absence of pneumonia due to M pneumoniae. To determine the relative frequency of such a condition, we retrospectively reviewed the medical records of adults over a 4-year period with a hospital discharge diagnosis of “bronchiolitis” from a university hospital. Setting University Hospital of the University of Colorado Health Sciences Center, Denver, CO. Study subjects From 1994 to 1998, 10 adult inpatients were identified with a diagnosis of bronchiolitis. There were two with respiratory bronchiolitis, one with panbronchiolitis, one patient with bronchiolitis obliterans organizing pneumonia (BOOP), and six with acute inflammatory bronchiolitis. Including the initial patient, three had a definitive clinical diagnosis of Mycoplasma-associated bronchiolitis. Results The three adult patients with bronchiolitis due to M pneumoniae are unusual because they occurred in the absence of radiographic features of a lobar or patchy alveolar pneumonia. Hospital admission was occasioned by the severity of symptoms and gas exchange abnormalities. One patient had bronchiolitis as well as organizing pneumonia (BOOP) that responded favorably to corticosteroid treatment. The other two had high-resolution CT findings diagnostic of an acute inflammatory bronchiolitis. One of the patients with inflammatory bronchiolitis had an unusual pattern of marked ventilation and perfusion defects localized predominantly to the left lung. All three had restrictive ventilatory impairment on physiologic testing. Conclusions In adults, Mycoplasma-associated bronchiolitis without pneumonia is rarely reported, but in hospitalized patients, it may be more common than expected and may be associated with severe physiologic disturbances. url: https://www.sciencedirect.com/science/article/pii/S0012369216377613 doi: 10.1378/chest.115.4.1188 id: cord-027678-k64whepc author: Chan, Kai Man title: Pneumonia date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310946/ doi: 10.1016/b978-0-7020-4762-6.00036-9 id: cord-278682-s4gfbsqy author: Chan, W-M title: Precautions in ophthalmic practice in a hospital with a major acute SARS outbreak: an experience from Hong Kong date: 2005-04-29 words: 4131.0 sentences: 218.0 pages: flesch: 47.0 cache: ./cache/cord-278682-s4gfbsqy.txt txt: ./txt/cord-278682-s4gfbsqy.txt summary: The ultimate infectivity of the tears secretion and ocular discharge from SARS patients may bring impacts on not only the daily ophthalmic practice but also the universal infection control measures practiced by general public and health-care workers. Discard gloves, wash or alcohol-rub the hands and then put on new gloves in-between case Wear glove in high-risk procedure General categories: for all patients attending the ophthalmic outpatients in which the SARS status is not certain. In a case-control study among 254 Hong Kong health-care workers with documented exposure to SARS patients, none of the 69 staff reporting use of four infection control measures, namely mask, gloves, gowns, and hand washing, was infected. Hospital Authority guideline on infection control of Severe Acute Respiratory Syndrome (SARS) abstract: Many new infectious diseases in humans have been derived from animal sources in the past 20 years. Some are highly contagious and fatal. Vaccination may not be available and antiviral drugs are not effective enough. Infectious control is important in clinical medicine and in Ophthalmology. Severe acute respiratory syndrome (SARS), as an example, is a highly contagious respiratory disease that has recently been reported in Asia, North America, and Europe. Within a matter of weeks, the outbreak has evolved to become a global health threat and more than 30 countries have been afflicted with a novel Coronavirus strain (SARS-CoV) that is the aetiologic agent of SARS. The primary route of transmission of SARS appears involving close person-to-person contact through droplets. Ophthalmologists may be particularly susceptible to the infection as routine ophthalmic examinations like direct ophthalmoscopy and slit-lamp examination are usually performed in a setting that has close doctor–patient contact. Being the Ophthalmology Department of the only hospital in the world that has just gone through the largest outbreak of SARS, we would like to share our strategy, measures, and experiences of preventing contracting or spreading of SARS infection as an infection control model. SARS is one of the many viruses against which personnel will need protecting in an ophthalmic setting. The experiences attained and the measures established might also apply to other infectious conditions spreading by droplets such as the avian influenza with H5N1. url: https://www.ncbi.nlm.nih.gov/pubmed/15877099/ doi: 10.1038/sj.eye.6701885 id: cord-316170-ihh0pxov author: Chang, De title: Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection date: 2020-05-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1164/rccm.202003-0524le doi: 10.1164/rccm.202003-0524le id: cord-285907-xoiju5ub author: Chang, Shang-Miao title: Comparative study of patients with and without SARS WHO fulfilled the WHO SARS case definition date: 2005-05-31 words: 3607.0 sentences: 192.0 pages: flesch: 59.0 cache: ./cache/cord-285907-xoiju5ub.txt txt: ./txt/cord-285907-xoiju5ub.txt summary: Abstract To differentiate severe acute respiratory syndrome (SARS) from non-SARS illness, we retrospectively compared 53 patients with probable SARS and 31 patients with non-SARS who were admitted to Mackay Memorial Hospital from April 27 to June 16, 2003. SARS patients with an initially normal chest X-ray study developed infiltrates at a mean of 5 ± 3.44 days after onset of fever (21/22 SARS vs. Severe acute respiratory syndrome (SARS) is a rapidly progressive disease caused by a novel coronavirus. Initial chest X-ray studies were normal in 22 of 53 SARS patients (41%) and 5 of 31 non-SARS patients (16%) ( Table 4 ). All except 1 of the 22 SARS patients with an initially normal chest X-ray study eventually developed abnormalities (mean FD 5 Ϯ 3.44). No non-SARS patient with an initially negative chest X-ray developed abnormalities on follow-up films. abstract: Abstract To differentiate severe acute respiratory syndrome (SARS) from non-SARS illness, we retrospectively compared 53 patients with probable SARS and 31 patients with non-SARS who were admitted to Mackay Memorial Hospital from April 27 to June 16, 2003. Fever (> 38°C) was the earliest symptom (50/53 SARS vs. 5/31 non-SARS, p < 0.0001), preceding cough by a mean of 4.5 days. The initial chest X-ray study was normal in 22/53 SARS cases versus 5/31 non-SARS cases. SARS patients with an initially normal chest X-ray study developed infiltrates at a mean of 5 ± 3.44 days after onset of fever (21/22 SARS vs. 0/5 non-SARS). Rapid radiographic progression of unifocal involvement to multifocal infiltrates was seen in 22 of 24 SARS vs. 0 of 26 non-SARS patients (p < 0.0001). Pleural effusion was not present in any SARS patients but was seen in 6 of 26 non-SARS cases (p < 0.0001). Initial lymphopenia, thrombocytopenia, and elevated lactate dehydrogenase were all more common in SARS than non-SARS (p < 0.0001). They may help differentiate SARS from non-SARS if a reliable and rapid diagnostic test is not available. url: https://www.ncbi.nlm.nih.gov/pubmed/15837019/ doi: 10.1016/j.jemermed.2004.11.022 id: cord-002956-e5ihpe4i author: Chang, Ya-Chun title: Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure date: 2018-04-04 words: 4666.0 sentences: 272.0 pages: flesch: 46.0 cache: ./cache/cord-002956-e5ihpe4i.txt txt: ./txt/cord-002956-e5ihpe4i.txt summary: title: Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure A total of 379 patients with sepsis or septic shock and acute respiratory failure requiring mechanical ventilation were admitted to the medical intensive care unit in the Kaohsiung Chang Gung Memorial Hospital from August 2013 to October 2015. We also tested and found that SOFA PaO 2 /FiO 2 subscore and GCS subscore on admission day 7 could help predict ventilator dependence on sepsis and septic shock patients with significant difference in univariate analysis ( Table 5 ). Ventilator dependence risk score, including a history of stroke and data from day 7 (thrombocytopenia, acidosis, and the higher fraction of inspired oxygen), can be applied to predict prolonged mechanical ventilation in patients who survive sepsis and septic shock. abstract: We intended to develop a scoring system to predict mechanical ventilator dependence in patients who survive sepsis/septic shock with respiratory failure. This study evaluated 251 adult patients in medical intensive care units (ICUs) between August 2013 to October 2015, who had survived for over 21 days and received aggressive treatment. The risk factors for ventilator dependence were determined. We then constructed a ventilator dependence (VD) risk score using the identified risk factors. The ventilator dependence risk score was calculated as the sum of the following four variables after being adjusted by proportion to the beta coefficient. We assigned a history of previous stroke, a score of one point, platelet count less than 150,000/μL a score of one point, pH value less than 7.35 a score of two points, and the fraction of inspired oxygen on admission day 7 over 39% as two points. The area under the curve in the derivation group was 0.725 (p < 0.001). We then applied the VD risk score for validation on 175 patients. The area under the curve in the validation group was 0.658 (p = 0.001). VD risk score could be applied to predict prolonged mechanical ventilation in patients who survive sepsis/septic shock. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884833/ doi: 10.1038/s41598-018-24028-4 id: cord-311215-x3b7ewo2 author: Chao, Tiffany N. title: Tracheotomy in Ventilated Patients With COVID-19 date: 2020-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1097/sla.0000000000003956 doi: 10.1097/sla.0000000000003956 id: cord-268324-86a0n0dc author: Charitos, Ioannis A title: Special features of SARS-CoV-2 in daily practice date: 2020-09-26 words: 6117.0 sentences: 279.0 pages: flesch: 42.0 cache: ./cache/cord-268324-86a0n0dc.txt txt: ./txt/cord-268324-86a0n0dc.txt summary: The severe acute respiratory syndrome-coronavirus-2 (commonly known as SARS-CoV-2) is a novel coronavirus (designated as 2019-nCoV), which was isolated for the first time after the Chinese health authorities reported a cluster of pneumonia cases in Wuhan, China in December 2019. The clinical picture of critical patients with severe inflammatory-induced lung disease and with sepsis or septic shock needing intensive care support and mechanical ventilation is characterized by a wide range of signs and symptoms of life-threatening multiorgan dysfunction or failure, including dyspnoea, tachypnoea (respiratory rate of > 30/min), tachycardia, chest pain or tightness, hypoxemia, virus-induced distributive shock, cardiac dysfunction, elevations in multiple inflammatory cytokines, renal impairment with oliguria, altered mental status, functional alterations of organs expressed as laboratory data of hyperbilirubinemia, acidosis [serum lactate level > 2 mmol/L (18 mg/dL)], coagulopathy, and thrombocytopenia. abstract: The severe acute respiratory syndrome-coronavirus-2 (commonly known as SARS-CoV-2) is a novel coronavirus (designated as 2019-nCoV), which was isolated for the first time after the Chinese health authorities reported a cluster of pneumonia cases in Wuhan, China in December 2019. Optimal management of the Coronavirus Disease-2019 disease is evolving quickly and treatment guidelines, based on scientific evidence and experts’ opinions with clinical experience, are constantly being updated. On January 30, 2020, the World Health Organization declared the SARS-CoV-2 outbreak as a "Public Health Emergency of International Concern". The total lack of immune protection brought about a severe spread of the contagion all over the world. For this reason, diagnostic tools, patient management and therapeutic approaches have been tested along the way, in the desperate race to break free from the widespread infection and its fatal respiratory complications. Current medical knowledge and research on severe and critical patients’ management and experimental treatments are still evolving, but several protocols on minimizing risk of infection among the general population, patients and healthcare workers have been approved and diffused by International Health Authorities. url: https://www.ncbi.nlm.nih.gov/pubmed/33024749/ doi: 10.12998/wjcc.v8.i18.3920 id: cord-280233-avmisu31 author: Chase, J. Geoffrey title: Safe doubling of ventilator capacity: a last resort proposal for last resorts date: 2020-05-14 words: 1641.0 sentences: 105.0 pages: flesch: 54.0 cache: ./cache/cord-280233-avmisu31.txt txt: ./txt/cord-280233-avmisu31.txt summary: In light of the COVID-19 pandemic, this commonsense approach was recently clarified in a SCCM-ASA-AARC-AACN-ASPF-CHEST consensus statement on the Society of Critical Care Medicine (SCCM) website [1] : ''We recommend that clinicians do not attempt to ventilate more than one patient with a single ventilator while any clinically proven, safe, and reliable therapy remains available (ie, in a dire, temporary emergency)'' [1] . In-parallel is a critical point, as inspiration and expiration all take place at the same time, so there is thus no change to respiratory rate (RR) and tidal volume or driving pressure are adjusted for the number of patients. Instead of the same RR and higher tidal volume or driving pressure, in-series breathing doubles the RR and keeps the other ventilator settings the same. PC driving pressure and VC tidal volume would have to be the same as ventilators currently do not have the capability to enable alternating breath settings. abstract: nan url: https://doi.org/10.1186/s13054-020-02945-z doi: 10.1186/s13054-020-02945-z id: cord-277700-nxm1jr0x author: Chassagnon, Guillaume title: AI-Driven CT-based quantification, staging and short-term outcome prediction of COVID-19 pneumonia date: 2020-04-22 words: 4879.0 sentences: 245.0 pages: flesch: 49.0 cache: ./cache/cord-277700-nxm1jr0x.txt txt: ./txt/cord-277700-nxm1jr0x.txt summary: (i) Two independent cohorts with quantification based on ensemble 2D & 3D consensus neural networks reaching expert-level annotations on massive evaluation, (ii) Consensus-driven bio(imaging)-marker selection on the principle of prevalence across methods leading to variables highly-correlated with outcomes & (iii) Consensus of linear & non-linear classification methods for staging and prognosis reaching optimal performance (minimum discrepancy between training & testing). The approach relied on (i) a disease quantification solution that exploited 2D & 3D convolutional neural networks using an ensemble method, (ii) a biomarker discovery approach sought to determine the share space of features that are the most informative for staging & prognosis, & (iii) an ensemble robust supervised classification method to distinguish patients with severe vs non-severe short-term outcome and among severe patients those intubated and those who did not survive. abstract: Chest computed tomography (CT) is widely used for the management of Coronavirus disease 2019 (COVID-19) 49 pneumonia because of its availability and rapidity. The standard of reference for confirming COVID-19 relies on microbiological tests but these tests might not be available in an emergency setting and their results are not immediately available, contrary to CT. In addition to its role for early diagnosis, CT has a prognostic role by allowing visually evaluating the extent of COVID-19 lung abnormalities. The objective of this study is to address prediction of short-term outcomes, especially need for mechanical ventilation. In this multi-centric study, we propose an end-to-end artificial intelligence solution for automatic quantification and prognosis assessment by combining automatic CT delineation of lung disease meeting the performance of experts and data-driven identification of biomarkers for its prognosis. AI-driven combination of variables with CT-based biomarkers offers perspectives for optimal patient management given the shortage of intensive care beds and ventilators. url: http://medrxiv.org/cgi/content/short/2020.04.17.20069187v1?rss=1 doi: 10.1101/2020.04.17.20069187 id: cord-270776-oulnk1b3 author: Chau, Tai-nin title: Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome date: 2004-08-15 words: 2775.0 sentences: 142.0 pages: flesch: 45.0 cache: ./cache/cord-270776-oulnk1b3.txt txt: ./txt/cord-270776-oulnk1b3.txt summary: title: Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome Purpose To determine whether the initial chest radiograph is helpful in predicting the clinical outcome of patients with severe acute respiratory syndrome (SARS). Results Bilateral disease and involvement of more than two zones on the initial chest radiograph were associated with a higher risk of liver impairment and poor clinical outcome. Together with the clinical characteristics of SARS, such as fever and chest symptoms, and a recent history of contact with a suspected or confirmed SARS patient, radiographic evidence of infiltrates consistent with pneumonia or acute respiratory distress syndrome is important in establishing the diagnosis (5) . Studies involving patients with community-acquired pneumonia (10) , acute interstitial pneumonia (11) , or idiopathic pulmonary fibrosis (12) have shown that quantitative and qualitative changes on chest radiographs might predict clinical outcome. abstract: Purpose To determine whether the initial chest radiograph is helpful in predicting the clinical outcome of patients with severe acute respiratory syndrome (SARS). Methods Of 343 patients who met the World Health Organization’s case definition of probable SARS and who had been admitted to a regional hospital in Hong Kong, 201 patients had laboratory evidence of SARS coronavirus infection. The initial frontal chest radiographs of these 201 patients were assessed in a blinded fashion by 3 radiologists; individual findings were accepted if at least 2 of the radiologists concurred. Independent predictors of an adverse outcome, defined as the need for assisted ventilation, death, or both, were identified by multivariate analysis. Results Bilateral disease and involvement of more than two zones on the initial chest radiograph were associated with a higher risk of liver impairment and poor clinical outcome. Forty-two patients (21%) developed an adverse outcome. Multivariate analysis showed that lung involvement of more than two zones (odds ratio [OR] = 7.0; 95% confidence interval [CI]: 2.7 to 17.9), older age (OR for each decade of life = 1.5; 95% CI: 1.1 to 2.0), and shortness of breath on admission (OR = 2.8; 95% CI: 1.1 to 7.4) were independent predictors of an adverse outcome. Conclusion Frontal chest radiographs on presentation may have prognostic value in patients with SARS. url: https://www.sciencedirect.com/science/article/pii/S0002934304003146 doi: 10.1016/j.amjmed.2004.03.020 id: cord-343743-6k3soh1l author: Chaudhary, Sachin title: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused date: 2020-09-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: After decades of research, two therapies for chronic fibrotic lung disease are now approved by the FDA, with dozens more anti-fibrotic therapies in the pipeline. A great deal of enthusiasm has been generated for the use of these drugs, which are by no means curative but clearly have a favorable impact on lung function decline over time. Amidst a flurry of newly developed and repurposed drugs to treat the coronavirus disease 2019 (COVID-19) and its accompanying acute respiratory distress syndrome (ARDS), few have emerged as effective. Historically, survivors of severe viral pneumonia and related acute lung injury with ARDS often have near full recovery of lung function. While the pathological findings of the lungs of patients with COVID-19 can be diverse, current reports have shown significant lung fibrosis predominantly in autopsy studies. There is growing enthusiasm to study anti-fibrotic therapy for inevitable lung fibrosis, and clinical trials are underway using currently FDA-approved anti-fibrotic therapies. Given the relatively favorable outcomes of survivors of virus-mediated ARDS and the low prevalence of clinically meaningful lung fibrosis in survivors, this perspective examines if there is a rationale for testing these repurposed antifibrotic agents in COVID-19-associated lung disease. url: https://www.ncbi.nlm.nih.gov/pubmed/33072773/ doi: 10.3389/fmed.2020.00539 id: cord-256688-yy7abob9 author: Chavez, Summer title: Coronavirus Disease (COVID-19): A primer for emergency physicians date: 2020-03-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Rapid worldwide spread of Coronavirus Disease 2019 (COVID-19) has resulted in a global pandemic. OBJECTIVE: This review article provides emergency physicians with an overview of the most current understanding of COVID-19 and recommendations on the evaluation and management of patients with suspected COVID-19. DISCUSSION: Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for causing COVID-19, is primarily transmitted from person-to-person through close contact (approximately 6 ft) by respiratory droplets. Symptoms of COVID-19 are similar to other viral upper respiratory illnesses. Three major trajectories include mild disease with upper respiratory symptoms, non-severe pneumonia, and severe pneumonia complicated by acute respiratory distress syndrome (ARDS). Emergency physicians should focus on identifying patients at risk, isolating suspected patients, and informing hospital infection prevention and public health authorities. Patients with suspected COVID-19 should be asked to wear a facemask. Respiratory etiquette, hand washing, and personal protective equipment are recommended for all healthcare personnel caring for suspected cases. Disposition depends on patient symptoms, hemodynamic status, and patient ability to self-quarantine. CONCLUSION: This narrative review provides clinicians with an updated approach to the evaluation and management of patients presenting to the emergency department with suspected COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32265065/ doi: 10.1016/j.ajem.2020.03.036 id: cord-350990-tywbe4o2 author: Checchi, Vittorio title: COVID‐19 dentistry‐related aspects: a literature overview date: 2020-07-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A new coronavirus (Sars‐CoV‐2) was detected in China at the end of 2019 and has since caused a worldwide pandemic. This virus is responsible for an acute respiratory syndrome (COVID‐19), distinguished by a potentially lethal interstitial bilateral pneumonia. Because Sars‐CoV‐2 is highly infective through airborne contamination, the high infection risk in the dental environment is a serious problem for both professional practitioners and patients. This literature overview provides a description of the clinical aspects of COVID‐19 and its transmission, while supplying valuable information regarding protection and prevention measures. url: https://doi.org/10.1111/idj.12601 doi: 10.1111/idj.12601 id: cord-267142-ys7z7j8j author: Cheema, Marvi title: Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19) date: 2020-04-02 words: 2462.0 sentences: 132.0 pages: flesch: 47.0 cache: ./cache/cord-267142-ys7z7j8j.txt txt: ./txt/cord-267142-ys7z7j8j.txt summary: This case emphasizes the importance of ensuring that first-line health care providers, including ophthalmologists, optometrists, emergency physicians, and family physicians, consider COVID-19 on the differential for any patient with recent travel who presents with acute conjunctivitis. At the time of the visits to our clinic (March 3rd and 5th), the patient did not meet provincial health authority recommendations for testing of coronavirus infectious disease 2019 (COVID-19) based on country of travel. 8 Given this, eye care professionals, most notably ophthalmologists, may be the first point of contact in the health care field for patients with possible COVID-19, before the onset of characteristic respiratory symptoms. The case emphasizes the importance for eye care professionals to remain vigilant and consider SARS-CoV-2 as the causative agent in patients presenting with viral conjunctivitis, particularly in high-risk patients with travel to areas of active transmission of the virus. abstract: We present a case of coronavirus disease 2019 (COVID-19) with an initial medical presentation of keratoconjunctivitis, the first such reported case in North America. The patient's primary symptom was a red eye with watery discharge, though she did have mild respiratory symptoms, without fever. She was diagnosed with keratoconjunctivitis; evolving corneal findings were characterized through repeat visits to ophthalmology. A conjunctival swab of the affected eye was positive for the SAR-CoV-2 virus. This case emphasizes the importance of ensuring that first-line health care providers, including ophthalmologists, optometrists, emergency physicians, and family physicians, consider COVID-19 on the differential for any patient with recent travel who presents with acute conjunctivitis. Having a high index of suspicion with this presentation would allow for appropriate precautions to be taken to prevent further spread of COVID-19. url: https://api.elsevier.com/content/article/pii/S0008418220303057 doi: 10.1016/j.jcjo.2020.03.003 id: cord-354749-zkgb16ae author: Chen, Gang title: Core principles for infection prevention in hemodialysis centers during the COVID-19 pandemic date: 2020-04-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32248855/ doi: 10.1017/ice.2020.109 id: cord-279134-s6c7m94h author: Chen, Haiyang title: When cancer encounters COVID-19 in China: what have we suffered, experienced and learned date: 2020-05-16 words: 4361.0 sentences: 206.0 pages: flesch: 45.0 cache: ./cache/cord-279134-s6c7m94h.txt txt: ./txt/cord-279134-s6c7m94h.txt summary: Therefore, it is of significance to summarize the relevant experience of China in the prevention and control of COVID-19 infection and treatment of patients with cancer during the epidemic. The delay of surgery because of COVID-19 epidemic may significantly affect the prognosis of patients with early stage lung cancer. It''s reported that a patient with NSCLC was treated with Kaletra (lopinavir/ritonavir) and osimertinib at the same time after the diagnosis of mild COVID-19 infection; 2 weeks after Kaletra treatment, pneumonia was cured and the tumor remained stable (23) . In the early stage of the epidemic, cross-infection in hospital is one of the most risk for patients and medical workers, so it is very important to screen COVID-19 patients as soon as admission of patients for cancer hospitals. abstract: The outbreak of the coronavirus disease (COVID-19) occurred in Wuhan, China, in December 2019. As of 21 March 2020, this epidemic has spread to 179 countries with more than 200 000 confirmed cases and 8578 deaths. The outbreak has put enormous pressure on the medical establishment and even led to exhaustion of medical resources in the most affected areas. Other medical work has been significantly affected in the context of COVID-19 epidemic. In order to reduce or avoid cross-infection with COVID-19, many hospitals have taken measures to limit the number of outpatient visits and inpatients. For example, emergency surgery can only be guaranteed, and most other surgeries can be postponed. Patients with cancer are one of the groups most affected by the epidemic because of their systematic immunosuppressive state and requirement of frequent admission to hospital. Consequently, specific adjustments for their treatment need to be made to cope with this situation. Therefore, it is of significance to summarize the relevant experience of China in the prevention and control of COVID-19 infection and treatment of patients with cancer during the epidemic. url: https://doi.org/10.1093/jjco/hyaa077 doi: 10.1093/jjco/hyaa077 id: cord-288197-drto66xt author: Chen, Huijun title: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records date: 2020-02-12 words: 3927.0 sentences: 225.0 pages: flesch: 54.0 cache: ./cache/cord-288197-drto66xt.txt txt: ./txt/cord-288197-drto66xt.txt summary: METHODS: Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Findings from this small group of cases suggest that there is currently no evidence for intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia in late pregnancy. Evidence of vertical transmission was assessed by testing for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in amniotic fluid, cord blood, breastmilk, and neonatal throat swab samples from six of nine patients. Based on data from this small group of patients, there is currently no evidence of vertical transmission in pregnant women who develop COVID-19 pneumonia in the third trimester. abstract: BACKGROUND: Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. METHODS: Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Evidence of intrauterine vertical transmission was assessed by testing for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. Breastmilk samples were also collected and tested from patients after the first lactation. FINDINGS: All nine patients had a caesarean section in their third trimester. Seven patients presented with a fever. Other symptoms, including cough (in four of nine patients), myalgia (in three), sore throat (in two), and malaise (in two), were also observed. Fetal distress was monitored in two cases. Five of nine patients had lymphopenia (<1·0 × 10⁹ cells per L). Three patients had increased aminotransferase concentrations. None of the patients developed severe COVID-19 pneumonia or died, as of Feb 4, 2020. Nine livebirths were recorded. No neonatal asphyxia was observed in newborn babies. All nine livebirths had a 1-min Apgar score of 8–9 and a 5-min Apgar score of 9–10. Amniotic fluid, cord blood, neonatal throat swab, and breastmilk samples from six patients were tested for SARS-CoV-2, and all samples tested negative for the virus. INTERPRETATION: The clinical characteristics of COVID-19 pneumonia in pregnant women were similar to those reported for non-pregnant adult patients who developed COVID-19 pneumonia. Findings from this small group of cases suggest that there is currently no evidence for intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia in late pregnancy. FUNDING: Hubei Science and Technology Plan, Wuhan University Medical Development Plan. url: https://www.ncbi.nlm.nih.gov/pubmed/32151335/ doi: 10.1016/s0140-6736(20)30360-3 id: cord-002782-mena480g author: Chen, Jiajia title: Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection date: 2017-12-08 words: 3021.0 sentences: 179.0 pages: flesch: 55.0 cache: ./cache/cord-002782-mena480g.txt txt: ./txt/cord-002782-mena480g.txt summary: Our findings suggest that pulmonary function and imaging findings improved during the first 6 months especially for those with ARDS, however long-term lung disability and psychological impairment in H7N9 survivors persisted at 2 years after discharge from the hospital. In survivors of H5N1 virus infection, radiologic abnormalities including ground-glass opacities with a reticular pattern remained evident at the 12-month follow-up visit 10 . A study of the long-term outcomes of survivors with ARDS reported a mild restrictive pattern on lung-function testing, with a mild-to-moderate reduction in carbon monoxide diffusion capacity at 3 months; The median DLCO improved by 9% of the predicted value from 3 to 12 months 13 . A meta-analysis showed that recovery in the HRQoL of ARDS survivors occurred during the first 6 months after discharge 20 , but no significant improvement was evident at the 2-year follow-up in our study. Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge abstract: Patients who survive influenza A (H7N9) virus infection are at risk of physical and psychological complications of lung injury and multi-organ dysfunction. However, there were no prospectively individualized assessments of physiological, functional and quality-of-life measures after hospital discharge. The current study aims to assess the main determinants of functional disability of these patients during the follow-up. Fifty-six influenza A (H7N9) survivors were investigated during the 2-year after discharge from the hospital. Results show interstitial change and fibrosis on pulmonary imaging remained 6 months after hospital discharge. Both ventilation and diffusion dysfunction improved, but restrictive and obstructive patterns on ventilation function test persisted throughout the follow-up period. For patients with acute respiratory distress syndrome lung functions improved faster during the first six months. Role-physical and Role-emotional domains in the 36-Item Short-Form Health Survey were worse than those of a sex- and age-matched general population group. The quality of life of survivors with ARDS was lower than those with no ARDS. Our findings suggest that pulmonary function and imaging findings improved during the first 6 months especially for those with ARDS, however long-term lung disability and psychological impairment in H7N9 survivors persisted at 2 years after discharge from the hospital. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722861/ doi: 10.1038/s41598-017-17497-6 id: cord-262467-epqqd8n8 author: Chen, Jun title: COVID-19 infection: the China and Italy perspectives date: 2020-06-08 words: 7596.0 sentences: 384.0 pages: flesch: 47.0 cache: ./cache/cord-262467-epqqd8n8.txt txt: ./txt/cord-262467-epqqd8n8.txt summary: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 disease as originally shown in Wuhan, China, as early as documented from 1 December 2019 (ref. A recent prospective study failed to find antiviral activity or clinical benefit of this combination for the treatment of our hospitalized patients with severe COVID-19 (ref. More recently, a randomized, controlled study conducted in Wuhan, China also failed to identify beneficial effect of LPV/r beyond standard therapy in hospitalized patients with severe Covid-19 (ref. Clinical trials also showed that in patients with severe H1N1 influenza A, in the 2009 pandemic, therapy with convalescent plasma from patients who recovered, especially within 5 days of symptom onset, resulted in a lower viral load and lower mortality 66, 67 . The duration from onset of symptoms to viral clearance is significantly longer in severe and critical ill SARS-CoV-2infected patients compared with that in the mild cases 48 . abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Since its first report in December 2019, despite great efforts made in almost every country worldwide, this disease continues to spread globally, especially in most parts of Europe, Iran, and the United States. Here, we update the recent understanding in clinical characteristics, diagnosis strategies, as well as clinical management of COVID-19 in China as compared to Italy, with the purpose to integrate the China experience with the global efforts to outline references for prevention, basic research, treatment as well as final control of the disease. Being the first two countries we feel appropriate to evaluate the evolution of the disease as well as the early result of the treatment, in order to offer a different baseline to other countries. It is also interesting to compare two countries, with a very significant difference in population, where the morbidity and mortality has been so different, and unrelated to the size of the country. url: https://www.ncbi.nlm.nih.gov/pubmed/32513951/ doi: 10.1038/s41419-020-2603-0 id: cord-264843-cwtdkylo author: Chen, Justin A. title: COVID-19 and telepsychiatry: Early outpatient experiences and implications for the future date: 2020-07-09 words: 4033.0 sentences: 237.0 pages: flesch: 44.0 cache: ./cache/cord-264843-cwtdkylo.txt txt: ./txt/cord-264843-cwtdkylo.txt summary: Within psychiatry, a sudden relaxing of insurance and regulatory barriers during the month of March 2020 enabled clinicians practicing in a wide range of settings to quickly adopt virtual care in order to provide critical ongoing mental health supports to both existing and new patients struggling with the pandemic''s impact. In this article, we briefly review the extensive literature supporting the effectiveness of telepsychiatry relative to in-person mental health care, and describe how payment and regulatory challenges were the primary barriers preventing more widespread adoption of this treatment modality prior to COVID-19. Finally, we provide clinical suggestions for optimizing telepsychiatry based on our experience, make a call for advocacy to continue the reduced insurance and regulatory restrictions affecting telepsychiatry even once this public health crisis has passed, and pose research questions that can help guide optimal utilization of telepsychiatry as mainstay or adjunct of outpatient psychiatric treatment now and in the future. abstract: The COVID-19 pandemic has dramatically transformed the U.S. healthcare landscape. Within psychiatry, a sudden relaxing of insurance and regulatory barriers during the month of March 2020 enabled clinicians practicing in a wide range of settings to quickly adopt virtual care in order to provide critical ongoing mental health supports to both existing and new patients struggling with the pandemic's impact. In this article, we briefly review the extensive literature supporting the effectiveness of telepsychiatry relative to in-person mental health care, and describe how payment and regulatory challenges were the primary barriers preventing more widespread adoption of this treatment modality prior to COVID-19. We then review key changes that were implemented at the federal, state, professional, and insurance levels over a one-month period that helped usher in an unprecedented transformation in psychiatric care delivery, from mostly in-person to mostly virtual. Early quality improvement data regarding virtual visit volumes and clinical insights from our outpatient psychiatry department located within a large, urban, tertiary care academic medical center reflect both the opportunities and challenges of virtual care for patients and providers. Finally, we provide clinical suggestions for optimizing telepsychiatry based on our experience, make a call for advocacy to continue the reduced insurance and regulatory restrictions affecting telepsychiatry even once this public health crisis has passed, and pose research questions that can help guide optimal utilization of telepsychiatry as mainstay or adjunct of outpatient psychiatric treatment now and in the future. url: https://doi.org/10.1016/j.genhosppsych.2020.07.002 doi: 10.1016/j.genhosppsych.2020.07.002 id: cord-184194-zdxebonv author: Chen, Lichin title: Using Deep Learning and Explainable Artificial Intelligence in Patients'' Choices of Hospital Levels date: 2020-06-24 words: 4915.0 sentences: 270.0 pages: flesch: 47.0 cache: ./cache/cord-184194-zdxebonv.txt txt: ./txt/cord-184194-zdxebonv.txt summary: This study used nationwide insurance data, accumulated possible features discussed in existing literature, and used a deep neural network to predict the patients choices of hospital levels. Focusing on the hospital levels of the patients'' choices, this study used explainable artificial intelligence (XAI) methods to interpret the effecting features for the general public and individuals. According to a public opinion poll conducted in 2019 [35] , although 85.3% of the respondents agreed that for a mild condition the patient should go to the primary care service nearby instead of tertiary hospitals, 70% considered institutes with higher levels to possess better professional skills, and 49% expressed having confidence in determining the severity of their own condition. According to our result, three features could interpret the majority of patients'' choices of hospital levels: the MFPC, LFPC, and physician density. abstract: In countries that enabled patients to choose their own providers, a common problem is that the patients did not make rational decisions, and hence, fail to use healthcare resources efficiently. This might cause problems such as overwhelming tertiary facilities with mild condition patients, thus limiting their capacity of treating acute and critical patients. To address such maldistributed patient volume, it is essential to oversee patients choices before further evaluation of a policy or resource allocation. This study used nationwide insurance data, accumulated possible features discussed in existing literature, and used a deep neural network to predict the patients choices of hospital levels. This study also used explainable artificial intelligence methods to interpret the contribution of features for the general public and individuals. In addition, we explored the effectiveness of changing data representations. The results showed that the model was able to predict with high area under the receiver operating characteristics curve (AUC) (0.90), accuracy (0.90), sensitivity (0.94), and specificity (0.97) with highly imbalanced label. Generally, social approval of the provider by the general public (positive or negative) and the number of practicing physicians serving per ten thousand people of the located area are listed as the top effecting features. The changing data representation had a positive effect on the prediction improvement. Deep learning methods can process highly imbalanced data and achieve high accuracy. The effecting features affect the general public and individuals differently. Addressing the sparsity and discrete nature of insurance data leads to better prediction. Applications using deep learning technology are promising in health policy making. More work is required to interpret models and practice implementation. url: https://arxiv.org/pdf/2006.13427v1.pdf doi: nan id: cord-261246-m40kwgcg author: Chen, Nanshan title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study date: 2020-01-30 words: 4003.0 sentences: 238.0 pages: flesch: 53.0 cache: ./cache/cord-261246-m40kwgcg.txt txt: ./txt/cord-261246-m40kwgcg.txt summary: title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study We describe epidemi ological data (ie, shortterm [occasional visits] and longterm [worked at or lived near] exposure to Huanan seafood market); demographics; signs and symptoms on admission; comorbidity; labora tory results; coinfection with other respiratory pathogens; chest radiography and CT findings; treatment received for 2019nCoV; and clinical outcomes. This study is, to our knowledge, the largest case series to date of 2019-nCoV infections, with 99 patients who were transferred to Jinyintan Hospital from other hospitals all over Wuhan, and provides further information on the demographic, clinical, epidemiological, and laboratory features of patients. This is an extended descriptive study on the epidemiology and clinical characteristics of the 2019nCoV, including data on 99 patients who were transferred to Jinyintan Hospital from other hospitals across Wuhan. abstract: BACKGROUND: In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. METHODS: In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. Outcomes were followed up until Jan 25, 2020. FINDINGS: Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the Huanan seafood market. The average age of the patients was 55·5 years (SD 13·1), including 67 men and 32 women. 2019-nCoV was detected in all patients by real-time RT-PCR. 50 (51%) patients had chronic diseases. Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). According to imaging examination, 74 (75%) patients showed bilateral pneumonia, 14 (14%) patients showed multiple mottling and ground-glass opacity, and one (1%) patient had pneumothorax. 17 (17%) patients developed acute respiratory distress syndrome and, among them, 11 (11%) patients worsened in a short period of time and died of multiple organ failure. INTERPRETATION: The 2019-nCoV infection was of clustering onset, is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In general, characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia. Further investigation is needed to explore the applicability of the MuLBSTA score in predicting the risk of mortality in 2019-nCoV infection. FUNDING: National Key R&D Program of China. url: https://api.elsevier.com/content/article/pii/S0140673620302117 doi: 10.1016/s0140-6736(20)30211-7 id: cord-332145-rw16o02g author: Chen, Patrick M. title: Evolving Healthcare Delivery in Neurology During the Coronavirus Disease 2019 (COVID-19) Pandemic date: 2020-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.3389/fneur.2020.00578 doi: 10.3389/fneur.2020.00578 id: cord-354689-dsv63it1 author: Chen, Qian title: Precautionary Measures: Performing ERCP on a Patient With Juxtapapillary Duodenal Diverticula (JPDD)-Related Biliary Stone After COVID-19 Lockdown Restriction Lifted in Wuhan, China date: 2020-09-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: On April 8, 2020, after nearly 3 months of battling against the outbreak of COVID-19, Wuhan, where the pandemic began, began easing lockdown restrictions. However, given that asymptomatic carriers could continue to lead to transmission of COVID-19 during the very early stages, the endoscopists have taken precautions and conduct risk assessments to perform endoscopic intervention in this transition stage. Here, we have reported an urgent ERCP in a patient with acute pancreatitis secondary to JPDD-related biliary stone. Based on our experiences, the objective is to provide practical suggestions for the safe resumption of ERCP procedures in the setting of the COVID-19 pandemic with specific focus on patient risk assessment, personal protection equipment (PPE), and dress code modalities, all of which have been implemented in our hospital to reduce the risk of viral transmission. url: https://www.ncbi.nlm.nih.gov/pubmed/33015107/ doi: 10.3389/fmed.2020.00564 id: cord-272778-aixiioii author: Chen, Qingqing title: Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China date: 2020-04-28 words: 3021.0 sentences: 175.0 pages: flesch: 53.0 cache: ./cache/cord-272778-aixiioii.txt txt: ./txt/cord-272778-aixiioii.txt summary: We recorded demographic data including age and gender, the clinical data including underlying diseases, medical history, exposure history, symptoms, signs, laboratory findings, chest computed tomographic (CT) scans, and treatment measures (ie, antiviral therapy, corticosteroid therapy, respiratory support), Sequential Organ Failure Assessment (SOFA) score, MuLBSTA score, the Acute Physiology and Chronic Health Evaluation (APACHE) II, epidemiological, and outcomes data. For severely and non-severely ill patients, refer to Diagnosis and Treatment of Pneumonia caused by SARS-CoV-2 (version 7) [19] issued by of National Health Commission of the People''s Republic of China. Last, we took reference on Diagnosis and Treatment of Pneumonia Caused by SARS-CoV-2 (version 7) [19] issued by of National Health Commission of the People''s Republic of China, to define the severity of COVID-19, so its applicability may be limited. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study abstract: OBJECTIVE: The aim of this study was to investigate the clinical characteristics of Corona Virus Disease 2019 in Taizhou, China. METHODS: A single center retrospective observational study was performed between Jan 1, 2020 and Mar 11, 2020 at Taizhou Public Health Medical Center, Zhejiang, China. All patients with confirmed Corona Virus Disease 2019 were enrolled, and their clinical data were gathered by reviewing electronic medical records. Outcomes of severely ill patients and non-severely ill patients were compared. RESULTS: Of 145 hospitalized patients with COVID-19, the average age was 47.5 years old (standard deviation, 14.6) and 54.5% were men. Hypertension was the most common comorbidity (15.2%), followed by diabetes mellitus (9.7%). Common symptoms included dry cough (81.4%), fever (75.2%), anorexia (42.8%), fatigue (40.7%), chest tightness (32.4%), diarrhea (26.9%) and dizziness (20%). According to imaging examination, 79.3% patients showed bilateral pneumonia, 18.6% showed unilateral pneumonia, 61.4% showed ground-glass opacity, and 2.1% showed no abnormal result. Compared with non-severely ill patients, severely ill patients were older (mean, years, 52.8 vs. 45.3, p < 0.01), had a higher proportion of diabetes mellitus (16.3% vs. 6.9%, p = 0.08), had a higher body mass index (mean, 24.78 vs. 23.20, p = 0.02) and were more likely to have fever (90.7% vs. 68.6%, p = 0.01), anorexia (60.5% vs. 35.3%, p = 0.01), chest tightness (60.5% vs.20.6%, p < 0.01) and dyspnea (7.0% vs. 0%, p = 0.03). Of the 43 severely ill patients, 6 (14%) received high-flow nasal cannula oxygen therapy, and 1 (2.3%) received invasive mechanical ventilation. CONCLUSIONS: Older patients or patients with comorbidities such as obesity or diabetes mellitus were more likely to have severe condition. Treatments of COVID-19 is still experimental and more clinical trials are needed. url: https://doi.org/10.1007/s15010-020-01432-5 doi: 10.1007/s15010-020-01432-5 id: cord-257206-av2k44ig author: Chen, Ruey title: Effects of a SARS prevention programme in Taiwan on nursing staff''s anxiety, depression and sleep quality: A longitudinal survey date: 2006-02-28 words: 5064.0 sentences: 278.0 pages: flesch: 59.0 cache: ./cache/cord-257206-av2k44ig.txt txt: ./txt/cord-257206-av2k44ig.txt summary: Abstract The aim of this research is to determine the levels of anxiety, depression, and sleep quality a severe acute respiratory syndrome (SARS) nursing staff experienced before and after a SARS prevention program. Using general estimating equations (GEE) statistical analysis to control possible for affecting factors, we found that the nursing staff''s anxiety and depression along with sleep quality started to improve 2 weeks after the initiation of SARS prevention controls. This research is to describe the anxiety level, depression level, and sleep quality of nursing staff who cared for SARS patients during a sweeping epidemic and the effects of a SARS prevention program. Tables 2 and 3 show the effects of the SARS prevention program on nursing staff through their self-reported levels of anxiety and depression as well as sleep quality. abstract: Abstract The aim of this research is to determine the levels of anxiety, depression, and sleep quality a severe acute respiratory syndrome (SARS) nursing staff experienced before and after a SARS prevention program. The 116 subjects were recruited from nursing staff in the largest obligatory SARS designated treatment hospital in Taiwan. Using general estimating equations (GEE) statistical analysis to control possible for affecting factors, we found that the nursing staff's anxiety and depression along with sleep quality started to improve 2 weeks after the initiation of SARS prevention controls. From this research, we determined that nursing staff members were anxious, depressed, and they could not sleep well at the SARS outbreak. However, the systematic SARS prevention program improved these factors. When faced with these types of diseases, related international medical organizations should establish a comprehensive program to help medical professionals cope better. url: https://www.sciencedirect.com/science/article/pii/S0020748905000684 doi: 10.1016/j.ijnurstu.2005.03.006 id: cord-349031-tbof9yqi author: Chen, Shiu-Jau title: Novel Antiviral Strategies in the Treatment of COVID-19: A Review date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2), is still a global public health problem for humans. It has caused more than 10,000,000 infections and more than 500,000 deaths in the world so far. Many scientists have tried their best to discover safe and effective drugs for the treatment of this disease; however, there are still no approved standard therapeutics or effective antiviral drugs on the market. Many new drugs are being developed, and several traditional drugs that were originally indicated or proposed for other diseases are likely to be effective in treating COVID-19, but their safety and efficacy are controversial, under study, or in clinical trial phases. Fortunately, some novel antiviral strategies, such as convalescent plasma, clustered regularly interspaced short palindromic repeats (CRISPR), and mesenchymal stem cell (MSC) therapy, potentially offer an additional or alternative option or compassionate use for the people suffering from COVID-19, especially for critically ill patients, although their safety and efficacy are also under study. In this review, we explore the applications, possible mechanisms, and efficacy in successful cases using convalescent plasma, CRISPR, and MSC therapy for COVID-19 treatment, respectively. Furthermore, the perspectives and limitations of these novel antiviral strategies are evaluated. url: https://doi.org/10.3390/microorganisms8091259 doi: 10.3390/microorganisms8091259 id: cord-263294-9r84f19u author: Chen, Siyu title: Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia date: 2020-04-10 words: 1069.0 sentences: 69.0 pages: flesch: 50.0 cache: ./cache/cord-263294-9r84f19u.txt txt: ./txt/cord-263294-9r84f19u.txt summary: The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID‐19) and provide help for clinical prevention and treatment. All five cases of pregnant women confirmed COVID‐19 were collected among patients who admitted to the Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020. Our study collected a total of five pregnant women with COVID-19, who were hospitalized for regular delivery in Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020 (Table 1 ). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy: report of two cases & review of the literature Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia abstract: The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID‐19) and provide help for clinical prevention and treatment. All five cases of pregnant women confirmed COVID‐19 were collected among patients who admitted to the Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020. All patients, aging from 25 to 31 years old, had the gestational week from 38th weeks to 41st weeks. All pregnant women did not have an antepartum fever but developed a low‐grade fever (37.5℃‐38.5℃) within 24 hours after delivery. All patients had normal liver and renal function, two patients had elevated plasma levels of the myocardial enzyme. Unusual chest imaging manifestations, featured with ground‐grass opacity, were frequently observed in bilateral (three cases) or unilateral lobe (two cases) by computed tomography (CT) scan. All labors smoothly processed, the Apgar scores were 10 points 1 and 5 minutes after delivery, no complications were observed in the newborn. Pregnancy and perinatal outcomes of patients with COVID‐19 should receive more attention. It is probable that pregnant women diagnosed with COVID‐19 have no fever before delivery. Their primary initial manifestations were merely low‐grade postpartum fever or mild respiratory symptoms. Therefore, the protective measures are necessary on admission; the instant CT scan and real‐time reverse‐transcriptase polymerase‐chain‐reaction assay should be helpful in early diagnosis and avoid cross‐infection on the occasion that patients have fever and other respiratory signs. url: https://doi.org/10.1002/jmv.25789 doi: 10.1002/jmv.25789 id: cord-300697-p96i25uc author: Chen, Taojiang title: A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report date: 2020-09-29 words: 2182.0 sentences: 128.0 pages: flesch: 43.0 cache: ./cache/cord-300697-p96i25uc.txt txt: ./txt/cord-300697-p96i25uc.txt summary: title: A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report CASE PRESENTATION: We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Additionally, despite the clinical manifestations of coronavirus disease 2019 (COVID-19) are dominated by respiratory symptoms, evidences from recent studies have suggested that SARS-CoV-2 has the ability to actively infect and replicate in the gastrointestinal tract [3] . Herein, we described an old-aged COVID-19 patient with multiple risk factors for severe disease and ultimately died from massive GIB at Wuhan Union Hospital. abstract: BACKGROUND: SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including nausea, diarrhea, and vomiting. Massive gastrointestinal bleeding, however, has rarely been reported. CASE PRESENTATION: We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired. CONCLUSIONS: Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection through faecal-oral transmission should be implemented in the process of patient care and infection control. url: https://www.ncbi.nlm.nih.gov/pubmed/32993509/ doi: 10.1186/s12876-020-01458-x id: cord-336252-e92omqyr author: Chen, Tracy Yixin title: COVID‐19 pneumonia in kidney transplant recipients: Focus on immunosuppression management date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The coronavirus disease of 2019, also known as COVID‐19, has been declared a global pandemic. Significant controversies exist regarding treatment modalities for this novel disease, especially in immunocompromised patients. Experience with management of COVID‐19 in kidney transplant recipients is scarce; effects of this virus on immunosuppressed individuals are not well understood. METHODS: We identified 30 renal transplant recipients with confirmed COVID‐19 pneumonia who were admitted to inpatient between March 2020 and April 2020. All patients received a 5‐day course of hydroxychloroquine and azithromycin; half of the patients received methylprednisolone. During hospitalization, calcineurin inhibitors and antimetabolites were held; prednisone was continued. RESULTS: Clinical presentation of flu‐like symptoms was similar to those in the general population. Hyponatremia, lymphopenia, acute kidney injury, and elevated inflammatory markers were common. Over the course of follow‐up, 23 have been discharged home with a functioning allograft and in stable condition; 4 experienced acute kidney injury requiring renal replacement therapy; 7 patients were intubated, and 6 expired. The mortality rate in our cohort was 20%. CONCLUSION: Our findings described the characteristics and outcomes of this highly fatal illness in a multi‐ethnic kidney transplant cohort, with insights on immunosuppression management that could further our understanding of this unique disease in immunocompromised populations. url: https://www.ncbi.nlm.nih.gov/pubmed/32573882/ doi: 10.1111/tid.13378 id: cord-289322-5ciaonf0 author: Chen, X. title: Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study date: 2020-03-06 words: 3871.0 sentences: 239.0 pages: flesch: 56.0 cache: ./cache/cord-289322-5ciaonf0.txt txt: ./txt/cord-289322-5ciaonf0.txt summary: title: Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study Methods: In this double-center, observational study, we recruited all consecutive patients with laboratory confirmed COVID-19 from January 23 to February 14, 2020 in two designated hospitals in Hunan province, China. Epidemiological and clinical data from patients'' electronic medical records were collected and compared between mild, moderate and severe/critical group in detail. Our study also showed the proportion of patients who had been to Wuhan in severe/critical group (48.0%) and moderate group (43.4%) were higher than mild group (17.2%). 77.6% patients with available coagulation function test result had elevated fibrinogen on admission, and the proportion in severe/critical group was even higher, which have not been observed in other studies. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study abstract: Abstract Background: The clinical outcomes of COVID-19 patients in Hubei and other areas are different. We aim to investigate the epidemiological and clinical characteristics of patient with COVID-19 in Hunan which is adjacent to Hubei. Methods: In this double-center, observational study, we recruited all consecutive patients with laboratory confirmed COVID-19 from January 23 to February 14, 2020 in two designated hospitals in Hunan province, China. Epidemiological and clinical data from patients' electronic medical records were collected and compared between mild, moderate and severe/critical group in detail. Clinical outcomes were followed up to February 20, 2020. Findings: 291 patients with COVID-19 were categorized into mild group (10.0%), moderate group (72.8%) and severe/critical group (17.2%). The median age of all patients was 46 years (49.8% were male). 86.6% patients had an indirect exposure history. The proportion of patients that had been to Wuhan in severe/critical group (48.0% vs 17.2%, p=0.006) and moderate group (43.4% vs 17.2%, p=0.007) were higher than mild group. Fever (68.7%), cough (60.5%), and fatigue (31.6%) were common symptoms especially for severe and critical patients. Typical lung imaging finding were bilateral and unilateral ground glass opacity or consolidation. Leukopenia, lymphopenia and eosinopenia occurred in 36.1%, 22.7% and 50.2% patients respectively. Increased fibrinogen was detected in 45 of 58 (77.6%) patients with available results. 29 of 44 (65.9%) or 22 of 40 (55.0%) patients were positive in Mycoplasma pneumonia or Chlamydia pneumonia antibody test respectively. Compared with mild or moderate group, severe/critical group had a relative higher level of neutrophil, Neutrophil-to-Lymphocyte Ratio, h-CRP, ESR, CK, CK-MB, LDH, D-dimer, and a lower level of lymphocyte, eosinophils, platelet, HDL and sodium (all p<0.01). Most patients received antiviral therapy and Chinese Medicine therapy. As of February 20, 2020, 159 (54.6%) patients were discharged and 2 (0.7%) patients died during hospitalization. The median length of hospital stay in discharged patients was 12 days (IQR: 10-15). Interpretation: The epidemiological and clinical characteristics of COVID-19 patients in Hunan is different from patients in Wuhan. The proportion of patients that had been to Wuhan in severe/critical group and moderate group were higher than mild group. Laboratory and imaging examination can assist in the diagnosis and classification of COVID-19 patients. url: http://medrxiv.org/cgi/content/short/2020.03.03.20030353v1?rss=1 doi: 10.1101/2020.03.03.20030353 id: cord-001078-5m29nugu author: Chen, Xiaorong title: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study date: 2013-09-17 words: 3930.0 sentences: 200.0 pages: flesch: 47.0 cache: ./cache/cord-001078-5m29nugu.txt txt: ./txt/cord-001078-5m29nugu.txt summary: title: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study OBJECTIVE: The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection. Factors analyzed for possible correlation with clinical features and treatment outcomes in patients included 1) baseline characteristics of patients, such as age, sex, occupation, underlying conditions, exposure to poultry and/or wild birds in the past seven days, date of symptom onset and hospital admission, date of specimen collection, and date of positive diagnosis; 2) results from laboratory tests and imaging examinations; 3) treatment regimen including basic supporting therapy, antibiotic therapy, antiviral therapy, traditional Chinese medicine (TCM) therapy, and other therapies if applicable; and 4) current condition of patients including the length of stay in the hospital. abstract: OBJECTIVE: The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection. METHODS: The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7N9 infection were noted and factors associated with treatment outcomes were analyzed by univariate analyses. RESULTS: The average ages of patients in recovered and critical conditions were 67.0±10.83 years and 72.75±12.0 years, respectively. Renal insufficiency developed more frequently in critically ill patients (P = 0.023). The duration of traditional Chinese medicine (TCM) therapy was longer in recovered patients than in critically ill patients (P = 0.01). Laboratory tests showed that levels of C-reactive protein, serum creatinine, and myoglobin were significantly higher in critically ill patients than in recovered patients (P = 0.011, 0.04, and 0.016, respectively). Meanwhile, levels of all T cell subsets examined including total CD3(+), CD4(+), CD8(+), and CD45(+) T cells were lower in critically ill patients than in recovered patients (P = 0.033, 0.059, 0.015, and 0.039, respectively). Logistic regression analysis demonstrated that C-reactive protein level, myoglobin level and TCM therapy duration were likely associated with treatment outcomes of H7N9 infection (P = 0.032, 0.041 and 0.017, respectively). CONCLUSION: Elderly people may have increased risk for H7N9 virus infection. T cell-mediated responses play an important role in defense against the H7N9 virus. C-reactive protein level, myoglobin level and TCM duration may be associated with treatment outcomes of H7N9 infection. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775774/ doi: 10.1371/journal.pone.0073362 id: cord-350737-nrtrhq1f author: Chen, Xinchun title: Serology of Severe Acute Respiratory Syndrome: Implications for Surveillance and Outcome date: 2004-04-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. Severe acute respiratory syndrome (SARS) is a novel infectious disease. No information is currently available on host-specific immunity against the SARS coronavirus (CoV), and detailed characteristics of the epidemiology of SARS CoV infection have not been identified. Methods. ELISA was used to detect antibody to SARS CoV. Reverse-transcriptase polymerase chain reaction was used to detect SARS CoV RNA. T cells in peripheral blood of patients were quantified by flow cytometry. Results. Of 36 patients with probable SARS CoV infection, 30 (83.3%) were positive for IgG antibody to SARS CoV; in contrast, only 3 of 48 patients with suspected SARS CoV infection, 0 of 112 patients with fever but without SARS, and 0 of 96 healthy control individuals were positive for it. IgG antibody to SARS CoV was first detected between day 5 and day 47 after onset of illness (mean ± SD, 18.7±10.4). Conclusion. Detection of antibody to SARS CoV is useful in the diagnosis of SARS; however, at the incubation and initial phases of the illness, serological assay is of little value, because of late seroconversion in most patients. url: https://www.ncbi.nlm.nih.gov/pubmed/15031782/ doi: 10.1086/380397 id: cord-264610-kxebc12r author: Chen, Yu title: Clinical characteristics of IgG4-RD patients infected with COVID-19 in Hubei, China date: 2020-05-16 words: 1700.0 sentences: 98.0 pages: flesch: 45.0 cache: ./cache/cord-264610-kxebc12r.txt txt: ./txt/cord-264610-kxebc12r.txt summary: title: Clinical characteristics of IgG4-RD patients infected with COVID-19 in Hubei, China Since IgG4-RD patients may be susceptible to infections due to the immune-related disease itself and the medications they take, we conducted a study to investigate COVID-19 infection rate in Hubei IgG4-RD patients during the recent outbreak in Hubei province, and to characterize the clinical manifestation of COVID-19 in IgG4-RD patients. Therefore, theoretically IgG4-RD patients have a high risk of progressing to severe/critical COVID-19 once infected and thus need to be identified and properly treated as early as possible. In summary, we describe the infection status and clinical characteristics of COVID-19 among IgG4-RD patients under the pandemic situation in this study. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in abstract: OBJECTIVE: IgG4-related disease (IgG4-RD) is an immune-mediated multi-organ, chronic and progressive disease. Therefore, we conducted a study to investigate the susceptibility of COVID-19 in IgG4-RD patients in Hubei province, and to characterize the clinical manifestation of COVID-19 in IgG4-RD patients. METHODS: A follow-up system that includes over 200 IgG4-RD patients across the country during the past ten years. A total of ninety-one patients with IgG4-RD who live in Hubei, China were identified and responded to our survey. Medical history, clinical symptoms, laboratory tests, CT imaging, and treatment were obtained through a standardized data collection form, and then independently reviewed by two investigators. RESULTS: 2 of 91 cases were infected with COVID-19. Both of them were classified as moderate type. The symptoms such as fever and cough and radiologic features were similar to other COVID-19 patients. Neither of them episode recurrent of IgG4-RD nor progressed to severe or critical condition of COVID-19 under the condition of continuous oral low-dose of glucocorticoids. Besides, patient 2 took a long time for SARS-CoV-2 nucleic acid to turn negative. CONCLUSION: IgG4-RD patients may belongs to the susceptible population of COVID-19 infection, and thus need more careful personal protection. Early identification and properly treatment are very important to prevent IgG4-RD patients with COVID-19 from progression to severe condition. url: https://www.sciencedirect.com/science/article/pii/S0049017220301293?v=s5 doi: 10.1016/j.semarthrit.2020.04.015 id: cord-353786-284qn075 author: Chen, Zhi-Min title: Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus date: 2020-02-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Since December 2019, an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in China. As of 8 pm, 31 January 2020, more than 20 pediatric cases have been reported in China. Of these cases, ten patients were identified in Zhejiang Province, with an age of onset ranging from 112 days to 17 years. Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. url: https://doi.org/10.1007/s12519-020-00345-5 doi: 10.1007/s12519-020-00345-5 id: cord-262150-j72jbohi author: Cheng, Chun-Hung title: RFID analytics for hospital ward management date: 2015-10-23 words: 7599.0 sentences: 368.0 pages: flesch: 47.0 cache: ./cache/cord-262150-j72jbohi.txt txt: ./txt/cord-262150-j72jbohi.txt summary: With a prototype developed based on the architecture of this platform, a pilot study was then conducted in two medical wards of the intensive care unit of one of the largest public general hospitals in Hong Kong to demonstrate the feasibility of its practical use. Here, we present the concept and architecture of an RFID-enabled platform for hospital ward management, which aims to provide inpatient care of higher quality, reduce patient risk, and optimize operations. After the outbreak of SARS, a project team from the CUHK considered the feasibility of using RFID technology to enable traceability for person-to-person physical contacts in order to provide immediate response to the widespread of infectious diseases and better risk management within hospital wards. In this paper, we presented an active RFID-enabled platform to keep track of the locations of patients, ward staff, and medical equipment, for hospital ward management. abstract: In this paper, we present an RFID-enabled platform for hospital ward management. Active RFID tags are attached to individuals and assets in the wards. Active RFID readers communicate with the tags continuously and automatically to keep track of the real-time information about the locations of the tagged objects. The data regarding the locations and other transmitted information are stored in the ward management system. This platform enables capabilities of real-time monitoring and tracking of individuals and assets, reporting of ward statistics, and providing intelligence and analytics for hospital ward management. All of these capabilities benefit hospital ward management by enhanced patient safety, increased operational efficiency and throughput, and mitigation of risk of infectious disease widespread. A prototype developed based on our proposed architecture of the platform was tested in a pilot study, which was conducted in two medical wards of the intensive care unit of one of the largest public general hospitals in Hong Kong. This pilot study demonstrates the feasibility of the implementation of this RFID-enabled platform for practical use in hospital wards. Furthermore, the data collected from the pilot study are used to provide data analytics for hospital ward management. url: https://www.ncbi.nlm.nih.gov/pubmed/32288935/ doi: 10.1007/s10696-015-9230-6 id: cord-332180-dw4h69tp author: Cheng, Fu-Yuan title: Using Machine Learning to Predict ICU Transfer in Hospitalized COVID-19 Patients date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objectives: Approximately 20–30% of patients with COVID-19 require hospitalization, and 5–12% may require critical care in an intensive care unit (ICU). A rapid surge in cases of severe COVID-19 will lead to a corresponding surge in demand for ICU care. Because of constraints on resources, frontline healthcare workers may be unable to provide the frequent monitoring and assessment required for all patients at high risk of clinical deterioration. We developed a machine learning-based risk prioritization tool that predicts ICU transfer within 24 h, seeking to facilitate efficient use of care providers’ efforts and help hospitals plan their flow of operations. Methods: A retrospective cohort was comprised of non-ICU COVID-19 admissions at a large acute care health system between 26 February and 18 April 2020. Time series data, including vital signs, nursing assessments, laboratory data, and electrocardiograms, were used as input variables for training a random forest (RF) model. The cohort was randomly split (70:30) into training and test sets. The RF model was trained using 10-fold cross-validation on the training set, and its predictive performance on the test set was then evaluated. Results: The cohort consisted of 1987 unique patients diagnosed with COVID-19 and admitted to non-ICU units of the hospital. The median time to ICU transfer was 2.45 days from the time of admission. Compared to actual admissions, the tool had 72.8% (95% CI: 63.2–81.1%) sensitivity, 76.3% (95% CI: 74.7–77.9%) specificity, 76.2% (95% CI: 74.6–77.7%) accuracy, and 79.9% (95% CI: 75.2–84.6%) area under the receiver operating characteristics curve. Conclusions: A ML-based prediction model can be used as a screening tool to identify patients at risk of imminent ICU transfer within 24 h. This tool could improve the management of hospital resources and patient-throughput planning, thus delivering more effective care to patients hospitalized with COVID-19. url: https://doi.org/10.3390/jcm9061668 doi: 10.3390/jcm9061668 id: cord-014980-cz1gx9oj author: Cheng, Qinglin title: Nomogram for the Individualized Prediction of Survival Among Patients with H7N9 Infection date: 2020-03-20 words: 6145.0 sentences: 315.0 pages: flesch: 46.0 cache: ./cache/cord-014980-cz1gx9oj.txt txt: ./txt/cord-014980-cz1gx9oj.txt summary: Stepwise selection was applied to the data, which resulted in a final model with 8 independent predictors [including initial PaO(2)/FiO(2) ratio ≤300 mmHg, age ≥60 years, chronic diseases, poor hand hygiene, time from illness onset to the first medical visit, incubation period ≤5 days, peak C-reactive protein ≥120 mg/L], and initial bilateral lung infection. 11 To better evaluate the predictors associated with survival outcomes, based on a matched case−control study (1:2 ratios), we retrospectively investigated the sociodemographic, clinical and epidemiological data of 227 laboratoryconfirmed cases of H7N9 VI in Zhejiang province, China, between March 1, 2013, and May 31, 2019. With 8 variables of training set such as IPFR ≤300 mmHg, IBLI, peak CRP ≥ 120 mg/L, TIOFMV, IP ≤ 5 days, CD, PHH, and age ≥60 years in Table 4 , it was possible to create a nomogram to predict the probability of survival from influenza A (H7N9) (Figure 2 ). abstract: BACKGROUND: Until recently, almost all of these studies have identified multiple risk factors but did not offer practical instruments for routine use in predicting individualized survival in human H7N9 infection cases. The objective of this study is to create a practical instrument for use in predicting an individualized survival probability of H7N9 patients. METHODS: A matched case–control study (1:2 ratios) was performed in Zhejiang Province between 2013 and 2019. We reviewed specific factors and outcomes regarding patients with H7N9 virus infection (VI) to determine relationships and developed a nomogram to calculate individualized survival probability. This tool was used to predict each individual patient’s probability of survival based on results obtained from the multivariable Cox proportional hazard regression analysis. RESULTS: We examined 227 patients with H7N9 VI enrolled in our study. Stepwise selection was applied to the data, which resulted in a final model with 8 independent predictors [including initial PaO(2)/FiO(2) ratio ≤300 mmHg, age ≥60 years, chronic diseases, poor hand hygiene, time from illness onset to the first medical visit, incubation period ≤5 days, peak C-reactive protein ≥120 mg/L], and initial bilateral lung infection. The concordance index of this nomogram was 0.802 [95% confidence interval (CI): 0.694–0.901] and 0.793 (95% CI: 0.611–0.952) for the training and validation sets, respectively, which indicates adequate discriminatory power. The calibration curves for the survival showed optimal agreement between nomogram prediction and actual observation in the training and validation sets, respectively. CONCLUSION: We established and validated a novel nomogram that can accurately predict the survival probability of patients with H7N9 VI. This nomogram can serve an important role in counseling patients with H7N9 VI and guide treatment decisions. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094003/ doi: 10.2147/rmhp.s242168 id: cord-288558-rthnj6wd author: Cheng, V. C. C. title: Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome date: 2004-02-15 words: 3801.0 sentences: 201.0 pages: flesch: 46.0 cache: ./cache/cord-288558-rthnj6wd.txt txt: ./txt/cord-288558-rthnj6wd.txt summary: The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log 10 vs. A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log 10 vs. In this retrospective study, we attempt to correlate the virus load of SARS coronavirus shedding from the nasopharynx, the upper end of the aerodigestive tract, with the presence of diarrhea in a cohort of patients with SARS. abstract: The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. Data from daily hematological, biochemical, radiological, and microbiological investigations were prospectively collected, and the correlation of these findings with diarrhea was retrospectively analyzed. Sixty-nine patients (48.6%) developed diarrhea at a mean (± standard deviation [SD]) of 7.6 ± 2.6 days after the onset of symptoms. The diarrhea was most severe at a mean (±SD) of 8.8 ± 2.4 days after onset, with a maximum frequency of 24 episodes per day (median, 5 episodes; range, 3–24 episodes). A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log(10) vs. 1.8 log(10) copies/mL; P = .01) and mortality (6.2 vs. 1.7 log(10) copies/mL; P < .01). However, diarrhea was not associated with mortality. The lung and the gastrointestinal tract may react differently to SARS coronavirus infection. Additional investigation of the role of SARS coronavirus in the pathogenesis of diarrhea in patients with SARS should be conducted. url: https://www.ncbi.nlm.nih.gov/pubmed/14765337/ doi: 10.1086/382681 id: cord-035070-drt6esrk author: Cheng, Yichun title: Risk Factors and Outcomes of Acute Kidney Injury in Critically Ill Patients with Coronavirus Disease 2019 date: 2020-10-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) has emerged as a major global health threat with a great number of deaths worldwide. Acute kidney injury (AKI) is a common complication in patients admitted to the intensive care unit. We aimed to assess the incidence, risk factors and in-hospital outcomes of AKI in COVID-19 patients admitted to the intensive care unit. METHODS: We conducted a retrospective observational study in the intensive care unit of Tongji Hospital, which was assigned responsibility for the treatments of severe COVID-19 patients by the Wuhan government. AKI was defined and staged based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Mild AKI was defined as stage 1, and severe AKI was defined as stage 2 or stage 3. Logistic regression analysis was used to evaluate AKI risk factors, and Cox proportional hazards model was used to assess the association between AKI and in-hospital mortality. RESULTS: A total of 119 patients with COVID-19 were included in our study. The median patient age was 70 years (interquartile range, 59–77) and 61.3% were male. Fifty-one (42.8%) patients developed AKI during hospitalization, corresponding to 14.3% in stage 1, 28.6% in stage 2 and 18.5% in stage 3, respectively. Compared to patients without AKI, patients with AKI had a higher proportion of mechanical ventilation mortality and higher in-hospital mortality. A total of 97.1% of patients with severe AKI received mechanical ventilation and in-hospital mortality was up to 79.4%. Severe AKI was independently associated with high in-hospital mortality (OR: 1.82; 95% CI: 1.06–3.13). Logistic regression analysis demonstrated that high serum interleukin-8 (OR: 4.21; 95% CI: 1.23–14.38), interleukin-10 (OR: 3.32; 95% CI: 1.04–10.59) and interleukin-2 receptor (OR: 4.50; 95% CI: 0.73–6.78) were risk factors for severe AKI development. CONCLUSIONS: Severe AKI was associated with high in-hospital mortality, and inflammatory response may play a role in AKI development in critically ill patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649690/ doi: 10.1159/000512270 id: cord-283719-zmizyx7e author: Cheng, Yuan-Yang title: Rehabilitation Programs for Patients with COronaVIrus Disease 2019: Consensus Statements of Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation date: 2020-08-17 words: 2815.0 sentences: 175.0 pages: flesch: 40.0 cache: ./cache/cord-283719-zmizyx7e.txt txt: ./txt/cord-283719-zmizyx7e.txt summary: An online consensus meeting of an expert panel comprising members of the Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation was held to provide recommendations for rehabilitation protocols in each of the five COVID-19 stages, namely (1) outpatients with mild disease and no risk factors, (2) outpatients with mild disease and epidemiological risk factors, (3) hospitalized patients with moderate to severe disease, (4) ventilator-supported patients with clear cognitive function, and (5) ventilator-supported patients with impaired cognitive function. For patients with advanced disease severity, a well-designed rehabilitation program is even more crucial to improve pulmonary secretion clearance, ameliorates side-effects related to a prolonged bedridden state, and even prevents intensive care unit-acquired weakness. 8 Altogether, potentially significant risk factors for severe COVID-19 that should be identified and considered when designing rehabilitation programs include old age, male gender, hypertension, diabetes, respiratory disease, and CVD. 29 Chest physiotherapy strategies that promote airway clearance include the following: Another important issue in the rehabilitation of patients with moderate to severe disease is preventing deconditioning due to acute illness. abstract: Abstract The COronaVIrus Disease 2019 (COVID-19), which developed into a pandemic in 2020, has become a major healthcare challenge for governments and healthcare workers worldwide. Despite several medical treatment protocols having been established, a comprehensive rehabilitation program that can promote functional recovery is still frequently ignored. An online consensus meeting of an expert panel comprising members of the Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation was held to provide recommendations for rehabilitation protocols in each of the five COVID-19 stages, namely (1) outpatients with mild disease and no risk factors, (2) outpatients with mild disease and epidemiological risk factors, (3) hospitalized patients with moderate to severe disease, (4) ventilator-supported patients with clear cognitive function, and (5) ventilator-supported patients with impaired cognitive function. Apart from medications and life support care, a proper rehabilitation protocol that facilitates recovery from COVID-19 needs to be established and emphasized in clinical practice. url: https://www.sciencedirect.com/science/article/pii/S0929664620303892?v=s5 doi: 10.1016/j.jfma.2020.08.015 id: cord-260232-98gtlad6 author: Chenna, Avantika title: Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade date: 2020-06-29 words: 4301.0 sentences: 247.0 pages: flesch: 50.0 cache: ./cache/cord-260232-98gtlad6.txt txt: ./txt/cord-260232-98gtlad6.txt summary: title: Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade We present the case series of four patients (2 men and 2 women; 1 Caucasian and 3 African Americans; two survived and two died) with confirmed COVID-19, presenting with respiratory symptoms and acute kidney injury, who have been on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. We also discussed the role of ACE2 and the renin-angiotensin system (RAS) blockade in patients with COVID-19 infection along with pathogenesis. We presented the case series of four patients who were on angiotensin-converting enzyme inhibitors (ACE inhibitors) or angiotensin receptor blockers (ARBs) with COVID-19 infection and acute renal failure. hypothesized that the use of ACE2 modulation medications in hypertensive and diabetic patients increased the risk of developing severe COVID-19 infection [1] . abstract: The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage. There have been controversial hypotheses raised regarding the safety of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in COVID-19 (coronavirus disease 2019). We present the case series of four patients (2 men and 2 women; 1 Caucasian and 3 African Americans; two survived and two died) with confirmed COVID-19, presenting with respiratory symptoms and acute kidney injury, who have been on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Membrane-bound angiotensin-converting enzyme 2 (ACE2) has been implicated as the gateway for viral entry into the human cell in causing the infection. The factors contributing to acute kidney injury are diuretics, iodinated contrast administration, hemodynamic instability apart from ACE inhibitors, and angiotensin receptor blockers. The ACE inhibitors and ARBs were stopped in these patients due to acute kidney injury. We also discussed the role of ACE2 and the renin-angiotensin system (RAS) blockade in patients with COVID-19 infection along with pathogenesis. url: https://doi.org/10.1155/2020/8811931 doi: 10.1155/2020/8811931 id: cord-274632-d9z0m2l8 author: Chenna, Avantika title: Coronavirus Disease 2019 (COVID-19) in a Renal Transplant Patient date: 2020-05-09 words: 1265.0 sentences: 77.0 pages: flesch: 46.0 cache: ./cache/cord-274632-d9z0m2l8.txt txt: ./txt/cord-274632-d9z0m2l8.txt summary: Transplant patients are particularly at a higher risk of contracting COVID-19 because of their immunosuppressed state, and they have the propensity to develop opportunistic infections [1] . Transplant patients are particularly at a higher risk of contracting COVID-19 because of their immunosuppressed state, and they have the propensity to develop opportunistic infections [1] . Here, we describe a case of a renal transplant patient who developed COVID-19 and, unfortunately, died from the infection despite all medical management. The illness from COVID-19 in renal transplant recipients ranged from mild to severe, and few patients presented with atypical symptoms [1, 3] . Transplant patients constitute a population more vulnerable to develop COVID-19 because of their immunosuppressed state and higher risk for opportunistic infections. Case report of COVID-19 in a kidney transplant recipient: does immunosuppression alter the clinical presentation? Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19) abstract: Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Transplant patients are particularly at a higher risk of contracting COVID-19 because of their immunosuppressed state, and they have the propensity to develop opportunistic infections. The pre-immunosuppressed state, along with other existing comorbidities, can influence the outcomes of COVID-19 in transplant patients. We describe a case of a renal transplant patient who developed COVID-19. Real-time nucleic acid testing (NAT) should be done in deceased and living donors. The most common management strategy is the modification of immunosuppression along with current experimental strategies for COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32528774/ doi: 10.7759/cureus.8038 id: cord-352227-827987jf author: Chernevskaya, Ekaterina title: Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study date: 2020-06-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: High serum levels of certain aromatic microbial metabolites (AMM) are associated with severity and mortality in critically ill patients. Omics-based studies suggest gut dysbiosis and reduced microbiome diversity in critical conditions. However, the landscape of gut microbial metabolites is still to be outlined, not to mention the interplay correlation between the metabolome and gut microbiome in critically ill patients. The aim of this study was to analyze the association between serum and fecal levels of AMM and compare them with the composition of gut microbiota in critically ill patients in the acute and chronic stages. METHODS: In this prospective observational pilot study, we analyzed the temporal dynamics of the gut microbiome and the AMM spectrum across two distinct subgroups—acute critical ill (ACI) patients with nosocomial pneumonia and chronically critically ill (CCI) patients (9 subjects each group)—as well as performed comparison with 23 healthy volunteers. The AMM levels for each patient were measured using GC-MS in simultaneously taken serum and fecal samples (SFS). These parameters were compared with 16S rRNA fecal microbiome profiles. RESULTS: The observed proportions of bacterial taxa suggest a significant gut dysbiosis in the ACI and the CCI patients. Stronger imbalance in microbiome composition and dynamics observed in the ACI patients compared to the CCI ones resonates with a higher severity in the former group. The total levels of AMM in serum samples were higher for the ACI patients than for the CCI patients (3.7 (1.4–6.3) and 1.1 (1.0–1.6) μM, respectively; p = 0.0003). The qualitative composition of the SFS was also altered. We discovered significant associations between gut microbial taxa levels and metabolite concentrations in blood serum as well as in feces in each of the ACI and the CCI patients. CONCLUSIONS: Aromatic microbial metabolite profiles in the gut and the serum are interlinked and reflect a disruption of the gut microbial community in critically ill patients. url: https://doi.org/10.1186/s13054-020-03031-0 doi: 10.1186/s13054-020-03031-0 id: cord-319849-3shr5grg author: Cheruiyot, Isaac title: Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients date: 2020-11-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Emerging evidence suggests that a subset of coronavirus disease 2019 (COVID-19) patients may present with or develop cerebrovascular disease during the course of hospitalization. Whereas ischemic stroke in COVID-19 patients has been well described, data on intracranial hemorrhage (ICH) in these patients is still limited. We, therefore, conducted a rapid systematic review of current scientific literature to identify and consolidate evidence of ICH in COVID-19 patients. METHODS: A systematic search of literature was conducted between November 1, 2019, and August 14, 2020, on PubMed and China National Knowledge Infrastructure (CNKI) to identify eligible studies. RESULTS: A total of 23 studies describing ICH in 148 COVID-19 patients were included. The pooled incidence of ICH in COVID-19 patients was 0.7% (95% CI 0.5–0.9), with low levels of inter-study heterogeneity observed (I(2) = 33.6%, Cochran’s Q = 12.05, p = 0.149). Most of the patients were elderly male patients (65.8%) with comorbidities, the most common being systemic hypertension (54%). Hemorrhage involving multiple cranial compartments was reported in 9.5% of cases. Single compartments were involved in the rest, with intraparenchymal hemorrhage (IPH) being the most common variety (62.6%) and intraventricular hemorrhage (IVH) the least common (1.4%). Half of these patients were on some form of anticoagulation. Overall, the mortality rate in the COVID-19 patients with ICH was about 48.6%. CONCLUSION: Although relatively uncommon among COVID-19 patients, ICH is associated with a high mortality rate. Early identification of patients at risk of developing ICH, particularly with comorbid conditions and on anticoagulant therapy, may be important to improve outcomes. url: https://doi.org/10.1007/s10072-020-04870-z doi: 10.1007/s10072-020-04870-z id: cord-006179-7uv4yfv2 author: Cheuk, Daniel Ka Leung title: Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children date: 2007-09-29 words: 4580.0 sentences: 211.0 pages: flesch: 46.0 cache: ./cache/cord-006179-7uv4yfv2.txt txt: ./txt/cord-006179-7uv4yfv2.txt summary: Autologous hematopoietic stem cell transplant (AHSCT) has been advocated as a form of salvage therapy for children with high-risk or relapsed brain tumors but only limited data are available currently. Over the past decade, high-dose chemotherapy with autologous hematopoietic stem cell transplant (AHSCT) has been tried in patients with high-risk brain tumors in an attempt to eradicate residual neoplastic cells and improve cure rate. In conclusion, AHSCT can result in long-term survival with satisfactory functional status in children with recurrent brain tumors, especially for those who can achieve complete remission before transplant. High-dose busulfan and thiotepa with autologous bone marrow transplantation in childhood malignant brain tumors: a phase II study High-dose melphalan and cyclophosphamide with autologous bone marrow rescue for recurrent/progressive malignant brain tumors in children: a pilot pediatric oncology group study High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors abstract: Autologous hematopoietic stem cell transplant (AHSCT) has been advocated as a form of salvage therapy for children with high-risk or relapsed brain tumors but only limited data are available currently. We report the outcomes of pediatric brain tumors treated with AHSCT in a quaternary referral center in Hong Kong over 10 years (June 1996–May 2006). Thirteen patients with medulloblastoma (n = 9), cerebral primitive neuroectodermal tumor (n = 1), ependymoma (n = 1), germ cell tumor (n = 1) and cerebellar rhabdoid (n = 1) were transplanted because of tumor residual (n = 1) or recurrence (n = 12). Uniform upfront treatment protocols were adopted according to specific tumor types. Prior to AHSCT, 8 patients (61.5%) achieved complete remission and 5 (38.5%) were in partial remission. Conditioning employed thiotepa 300 mg/m(2), etoposide 250 mg/m(2 )and carboplatin 500 mg/m(2) daily for 3 days. Toxicity included mucositis and neutropenic fever in all patients, grade 4 hepatic toxicity in 4 patients (including hepatic veno-occlusive disease in 2 patients) and grade 4 renal toxicity in 1 patient. The 5-year event-free survival was 53.9%. Five patients died of disease recurrence or progression 8–21 months after transplant with a median disease-free period of 8 months post-transplant. One died of transplant-related complications in the early post-transplant period. Seven survived for a median of 5.4 years (maximum follow-up of 9.8 years), with six having Lansky-Karnofsky performance score above 80. All survivors had complete remission before transplant though 2 had leptomeningeal spread. We conclude that AHSCT can achieve long-term survival in children with recurrent brain tumor. However, those with macroscopic residual tumor before transplant cannot be salvaged. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100104/ doi: 10.1007/s11060-007-9478-0 id: cord-278325-ykcd7d59 author: Cheung, Carmen Ka Man title: Coronavirus Disease 2019 (COVID-19): A Haematologist''s Perspective date: 2020-07-28 words: 7672.0 sentences: 379.0 pages: flesch: 39.0 cache: ./cache/cord-278325-ykcd7d59.txt txt: ./txt/cord-278325-ykcd7d59.txt summary: Two meta-analyses showed that a lower platelet count is associated with an increased risk of severe disease and mortality in patients with COVID-19 and may serve as a marker for progression of illness [53, 54] . Experience from previous SARS patients, caused by SARS-CoV-1, suggested that coronavirus could cause thrombocytopenia by direct viral infection of bone marrow haematopoietic stem cells via CD13 or CD66a, formation of auto-antibodies and immune complexes, disseminated intravascular coagulopathy (DIC), and consumption of platelet in lung epithelium [61, 62] . The International Society on Thrombosis and Haemostasis (ISTH) suggested all patients (including non-critically ill) who require hospital admission for COVID-19 infection should receive a prophylactic dose of LMWH unless contraindicated (Table 2 ) [102] . Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19 abstract: Coronavirus disease 2019 (COVID-19) is affecting millions of patients worldwide. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the family Coronaviridae, with 80% genomic similarities to SARS-CoV. Lymphopenia was commonly seen in infected patients and has a correlation to disease severity. Thrombocytopenia, coagulation abnormalities, and disseminated intravascular coagulation were observed in COVID-19 patients, especially those with critical illness and non-survivors. This pandemic has caused disruption in communities and hospital services, as well as straining blood product supply, affecting chemotherapy treatment and haematopoietic stem cell transplantation schedule. In this article, we review the haematological manifestations of the disease and its implication on the management of patients with haematological disorders. url: https://www.ncbi.nlm.nih.gov/pubmed/32721958/ doi: 10.1159/000510178 id: cord-318262-w8oixzdg author: Chevance, A title: Ensuring mental health care during the SARS-CoV-2 epidemic in France: a narrative review date: 2020-04-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Objective: The lack of resources and coordination to face the coronavirus epidemic raises concerns for the health of patients with mental disorders in a country where we still have memories of the dramatic experience of famine in psychiatric hospitals during the Second World War. This article aims to propose guidance to ensure mental health care during the SARS-CoV epidemic in France. Methods: The authors performed a narrative review identifying relevant results in the scientific and medical literature and in local initiatives in France. Results: We identified four types of major vulnerabilities among patients with mental disorders during this pandemic: 1) medical comorbidities that are more frequently found among patients with mental disorders (cardiovascular and pulmonary pathologies, diabetes, obesity, etc.) which are risk factors for severe covid-19 infection; 2) age (the elderly form the population most vulnerable to the coronavirus); 3) cognitive and behavioural disorders, which can hamper compliance with confinement and hygiene measures and finally and 4) psychosocial vulnerability as a result of stigmatization and/or socio-economic difficulties. Furthermore, the mental health healthcare system is more vulnerable than other healthcare systems. Current government plans are poorly suited to psychiatric establishments in a context of major shortages of organizational, material and human resources. In addition, a certain number of structural aspects make the psychiatric institution particularly vulnerable: many beds have been closed, wards have high densities of patients, mental health community facilities are closed, and medical teams are understaffed and poorly trained to face infectious diseases. There are also major issues when referring patients with acute mental disorders to intensive care units. To maintain the continuity of psychiatric care in this pandemic situation, several directions can be considered, in particular with the creation of "COVID+ units". These units are under the dual supervision of a psychiatrist and an internist / infectious disease specialist; all new entrants are placed in quarantine for 14 days; the nursing staff receives specific training, daily medical check-ups and close psychological support. Family visits are prohibited and replaced by videoconference. At the end of hospitalization, in particular for the population of patients in compulsory ambulatory care situations, specific case-management are organized with the possibility of home visits, in order to support patients when they get back home and to help them cope with the experience of confinement, which is liable to induce recurrences of mental disorders. The total or partial closure of community mental health facilities is particularly disturbing for patients, but a regular follow-up is possible with telemedicine and should include the monitoring of suicide risk and psycho-education strategies; developing support platforms could also be very helpful in this context. Private practice psychiatrists also have a crucial role of information towards their patients on confinement and barrier measures, and also on measures to prevent the psychological risks inherent in confinement: maintenance of regular sleep r, physical exercise, social interactions, stress management and coping strategies, prevention of addictions, etc. They should also be trained to prevent, detect and treat early warning symptoms of post-traumatic stress disorder, because their prevalence was high in the regions of China most affected by the pandemic. Discussion: French mental healthcare is now facing a great and urgent need for reorganization and must also prepare in the coming days and weeks to face an epidemic of emotional disorders due to the confinement of the general population. url: https://www.ncbi.nlm.nih.gov/pubmed/32370982/ doi: 10.1016/j.encep.2020.04.005 id: cord-354373-lldfoptb author: Chi, Jeffrey title: COVID-19 Clinical Research date: 2020-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. As of April 22, over 650 clinical studies have been registered both in USA and internationally. Results from these studies are also coming at a brisk pace in this unprecedented emergency. AREAS COVERED: We searched the NCI website and Medline and summarize various national and international clinical trials and summarize few of the pivotal ones in this paper, including those specific to oncology population. Two hundred and eighty four studies are actively recruiting adults and children with confirmed COVID-19, including 25 are early-phase I/phase I, 72 phase II, 58 phase III, 12 phase IV, and 31 other trials. They can be categorized into four groups: drugs that combat SARS-CoV-2, immunomodulatory agents to counteract cytokine storm, convalescence plasma therapies and vaccines trials. EXPERT OPINION: It is hoped that these efforts will results in a successful treatment to COVID-19, especially in a timely fashion before the second pandemic expected in fall. It is essential to acknowledge the devotion and hard work of the clinical research team and clinical research volunteers. url: https://doi.org/10.33696/signaling.1.006 doi: 10.33696/signaling.1.006 id: cord-280278-gq1hnnwh author: Chi, Meng title: A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management date: 2020-06-08 words: 807.0 sentences: 56.0 pages: flesch: 50.0 cache: ./cache/cord-280278-gq1hnnwh.txt txt: ./txt/cord-280278-gq1hnnwh.txt summary: Health care workers are exposed to high-risk environments when patients infected with COVID-19 require advanced airway management. However, patients cannot wear masks during positive pressure ventilation and endotracheal intubation, exposing health care workers to high-risk environments, even if effective protective measures were taken. The PVC membrane should be sufficiently large (> 100 cm × 100 cm is recommended) to cover the head of the patient and have a hole (sealed when necessary) in the center for the connection between the face mask and the circuit during oxygen inhalation and positive pressure ventilation. Before advanced airway management, the PVC membrane with an assembled face mask under the membrane is placed over the patient''s mouth and nose for the induction of intubation (Fig. 1a) . Our appliance reduces the spread of droplets and aerosols from patients, blocking the airborne transmission route of the virus to a large extent and providing a new layer of protection for health care workers during advanced airway management. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32513230/ doi: 10.1186/s13054-020-02985-5 id: cord-294628-ecg13s7a author: Chia, Ming Li title: Managing COVID-19 in a Novel, Rapidly Deployable Community Isolation Quarantine Facility date: 2020-09-17 words: 3676.0 sentences: 206.0 pages: flesch: 52.0 cache: ./cache/cord-294628-ecg13s7a.txt txt: ./txt/cord-294628-ecg13s7a.txt summary: During the coronavirus disease 2019 (COVID-19) pandemic, Singapore implemented large-scale institutional isolation units called Community Care Facilities (CCFs) to combat the outbreak in the community by housing low-risk COVID-19 patients from April to August 2020. During the coronavirus disease 2019 (COVID-19) pandemic, Singapore implemented large-scale institutional isolation units called Community Care Facilities (CCFs) to combat the outbreak in the community by housing low-risk COVID-19 patients from April to August 2020. In the first month, a total of 3758 patients were admitted to 4 halls, 4929 in-house medical consults occurred, 136 patients were transferred to a hospital, 1 patient died 2 weeks after discharge, and no health care workers became infected. As such, isolation centers called Community Care Facilities (CCFs) were set up throughout the country to house patients with COVID-19 who were at low risk for dying of the disease. abstract: Singapore is one of the most densely populated small island–states in the world. During the coronavirus disease 2019 (COVID-19) pandemic, Singapore implemented large-scale institutional isolation units called Community Care Facilities (CCFs) to combat the outbreak in the community by housing low-risk COVID-19 patients from April to August 2020. The CCFs were created rapidly by converting existing public spaces and used a protocolized system, augmented by telemedicine to enable a low health care worker–patient ratio (98 health care workers for 3200 beds), to operate these unique facilities. In the first month, a total of 3758 patients were admitted to 4 halls, 4929 in-house medical consults occurred, 136 patients were transferred to a hospital, 1 patient died 2 weeks after discharge, and no health care workers became infected. This article shares the authors' experience in operating these massive-scale isolation facilities while prioritizing safety for all and ensuring holistic patient care in the face of a public health crisis and lean health care resources. url: https://doi.org/10.7326/m20-4746 doi: 10.7326/m20-4746 id: cord-335744-haj5a7tf author: Chibbaro, Salvatore title: How SARS-CoV-2 is forcing us to reconsider and reorganize our daily neurosurgical practice date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S0028377020300655 doi: 10.1016/j.neuchi.2020.05.001 id: cord-317575-srg9cyqp author: Chien, Chen‐Yu title: Proactive measures for the pandemic COVID‐19 infection in outpatient clinics of Otolaryngology Department date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1002/kjm2.12235 doi: 10.1002/kjm2.12235 id: cord-023169-obupqcua author: Chierakul, Wirongrong title: Leptospirosis date: 2013-10-21 words: 4982.0 sentences: 318.0 pages: flesch: 41.0 cache: ./cache/cord-023169-obupqcua.txt txt: ./txt/cord-023169-obupqcua.txt summary: The severe illness, characterized by febrile illness with jaundice, acute renal injury and bleeding, is recognized as Weil''s disease, though many different local names have been used such as Fort Bragg, mud, swamp and sugar cane fevers. Complications such as cholestatic jaundice, aseptic meningitis, acute renal injury, haemorrhage especially in the lung and myocarditis can occur and lead to a fatal outcome. 24 Complications such as jaundice, acute renal injury, haemorrhage, especially pulmonary haemorrhage, aseptic meningitis, myocarditis, shock, occur early during the course of illness. Acute pancreatitis has been reported rarely, although serum amylase may be raised in up to 60% of patients with severe disease due to renal impairment. Nowadays, the term ''Weil''s syndrome'' usually refers to the extremely severe form of leptospirosis, characterized by the combination of jaundice, renal dysfunction, and haemorrhagic diathesis, especially pulmonary haemorrhage. Acute febrile illness accompanied by jaundice and renal failure should always include leptospirosis in the differential diagnosis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167526/ doi: 10.1016/b978-0-7020-5101-2.00038-8 id: cord-264042-4hc2i25r author: Chim, Harvey title: Severe Acute Respiratory Syndrome in a Naval Diver date: 2006-06-17 words: 2133.0 sentences: 132.0 pages: flesch: 50.0 cache: ./cache/cord-264042-4hc2i25r.txt txt: ./txt/cord-264042-4hc2i25r.txt summary: In the early recovery period, potential problems during diving are caused by inadequate lung ventilation in relation to exercise level and increased breathing resistance attributable to weak respiratory muscles, with corresponding risk of hypoxia and hypercapnia, as well as decreased ability to respond to nonrespiratory problems during diving. From our experience, we suggest that computed tomographic scans of the thorax, lung function tests, and careful follow-up monitoring should play a vital role in the assessment of patients during the convalescent period, before certification of fitness to dive. S evere acute respiratory syndrome (SARS) is an emerging infectious disease that was first reported in Guangdong Province in southern China in November 2002 and subsequently caused outbreaks in Singapore, Hong Kong, Southeast Asia, and Canada. In the week following diagnosis of SARS in this patient, only essential personnel in the diving unit were required to report to work to prevent the possible spread of SARS. abstract: Severe acute respiratory syndrome (SARS) is a highly infectious, rapidly progressive, emerging disease. Early diagnosis and preventive measures are key for treatment and minimization of secondary spread. In the context of the armed forces, aggressive containment measures are essential to prevent an outbreak. In this study, we present the first reported case, to our knowledge, of SARS in a naval diver. The special physical requirements for divers and the potential complications associated with deep sea diving necessitate extensive investigation before certification of fitness for diving after SARS. In the early recovery period, potential problems during diving are caused by inadequate lung ventilation in relation to exercise level and increased breathing resistance attributable to weak respiratory muscles, with corresponding risk of hypoxia and hypercapnia, as well as decreased ability to respond to nonrespiratory problems during diving. Problems in the late recovery period include increased risk of diving complications (such as pulmonary barotrauma) resulting from fibrosis and scarring within the lung parenchyma, which are known complications of SARS. From our experience, we suggest that computed tomographic scans of the thorax, lung function tests, and careful follow-up monitoring should play a vital role in the assessment of patients during the convalescent period, before certification of fitness to dive. url: https://www.ncbi.nlm.nih.gov/pubmed/16808126/ doi: 10.7205/milmed.171.6.491 id: cord-344486-iu5flbcl author: Chiotos, Kathleen title: Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2 date: 2020-09-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Although Coronavirus Disease 2019 (COVID-19) is a mild infection in most children, a small proportion develop severe or critical illness. Data evaluating agents with potential antiviral activity continue to expand, such that updated guidance is needed regarding use of these agents in children. METHODS: A panel of pediatric infectious diseases physicians and pharmacists from 20 geographically diverse North American institutions was convened. Through a series of teleconferences and web-based surveys, a set of guidance statements was developed and refined based on review of the best available evidence and expert opinion. RESULTS: Given the typically mild course of COVID-19 in children, supportive care alone is suggested for most cases. For children with severe illness, defined as a supplemental oxygen requirement without need for non-invasive or invasive mechanical ventilation or extra-corporeal membrane oxygenation (ECMO), remdesivir is suggested, preferably as part of a clinical trial if available. Remdesivir should also be considered for critically ill children requiring invasive or non-invasive mechanical ventilation or ECMO. A duration of 5 days is appropriate for most patients. The panel recommends against the use of hydroxychloroquine or lopinavir-ritonavir (or other protease inhibitors) for COVID-19 in children. CONCLUSIONS: Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For children with severe or critical disease, this guidance offers an approach for decision-making regarding use of remdesivir. url: https://www.ncbi.nlm.nih.gov/pubmed/32918548/ doi: 10.1093/jpids/piaa115 id: cord-017897-mbwm0ytg author: Chiumello, Davide title: The Acute Respiratory Distress Syndrome: Diagnosis and Management date: 2018-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Acute respiratory distress syndrome (ARDS) is characterized by a new acute onset of hypoxemia secondary to a pulmonary edema of non-cardiogenic origin, bilateral lung opacities and reduction in respiratory system compliance after an insult direct or indirect to lungs. Its first description was in 1970s, and then several shared definitions tried to describe this clinical entity; the last one, known as Berlin definition, brought an improvement in predictive ability for mortality. In the present chapter, the diagnostic workup of the syndrome will be presented with particular attention to microbiological investigations which represent a milestone in the diagnostic process and to imaging techniques such as CT scan and lung ultrasound. Despite the treatment is mainly based on supportive strategies, attention should be applied to assure adequate respiratory gas exchange while minimizing the risk of ventilator-induced lung injury (VILI) onset. Therefore will be described several therapeutic approaches to ARDS, including noninvasive mechanical ventilation (NIMV), high-flow nasal cannulas (HFNC) and invasive ventilation with particular emphasis to risks and benefits of mechanical ventilation, PEEP optimization and lung protective ventilation strategies. Rescue techniques, such as permissive hypercapnia, prone positioning, neuromuscular blockade, inhaled vasodilators, corticosteroids, recruitment maneuvers and extracorporeal life support, will also be reviewed. Finally, the chapter will deal with the mechanical ventilation weaning process with particular emphasis on extrapulmonary factors such as neurologic, diaphragmatic or cardiovascular alterations which can lead to weaning failure. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122583/ doi: 10.1007/978-3-319-94189-9_11 id: cord-304321-y177sqee author: Cho, Ryan H. W. title: Pearls of experience for safe and efficient hospital practices in otorhinolaryngology—head and neck surgery in Hong Kong during the 2019 novel coronavirus disease (COVID-19) pandemic date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The 2019 novel coronavirus disease (COVID-19) epidemic originated in Wuhan, China and spread rapidly worldwide, leading the World Health Organization to declare an official global COVID-19 pandemic in March 2020. In Hong Kong, clinicians and other healthcare personnel collaborated closely to combat the outbreak of COVID-19 and minimize the cross-transmission of disease among hospital staff members. In the field of otorhinolaryngology—head and neck surgery (OHNS) and its various subspecialties, contingency plans were required for patient bookings in outpatient clinics, surgeries in operating rooms, protocols in wards and other services. Infected patients may shed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) particles into their environments via body secretions. Therefore, otolaryngologists and other healthcare personnel in this specialty face a high risk of contracting COVID-19 and must remain vigilant when performing examinations and procedures involving the nose and throat. In this article, we share our experiences of the planning and logistics undertaken to provide safe and efficient OHNS practices over the last 2 months, during the COVID-19 pandemic. We hope that our experiences will serve as pearls for otolaryngologists and other healthcare personnel working in institutes that serve large numbers of patients every day, particularly with regard to the sharing of clinical and administrative tasks during the COVID-19 pandemic. url: https://doi.org/10.1186/s40463-020-00427-4 doi: 10.1186/s40463-020-00427-4 id: cord-295971-jtv1jj2z author: Cho, Sun Young title: MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study date: 2016-07-09 words: 4637.0 sentences: 208.0 pages: flesch: 56.0 cache: ./cache/cord-295971-jtv1jj2z.txt txt: ./txt/cord-295971-jtv1jj2z.txt summary: BACKGROUND: In 2015, a large outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection occurred following a single patient exposure in an emergency room at the Samsung Medical Center, a tertiary-care hospital in Seoul, South Korea. INTERPRETATION: Our results showed increased transmission potential of MERS-CoV from a single patient in an overcrowded emergency room and provide compelling evidence that health-care facilities worldwide need to be prepared for emerging infectious diseases. Excluding three patients with confi rmed MERS-CoV infection who were not identifi ed in the initial patient contact investigation (appendix p 5), the overall attack rate for patients in the emergency room was 4% (30 of 675). No MERS-CoV infection was reported in patients and visitors who had been in the emergency room on May 29 during the time period when they were exposed only to zones II (n=81) or III (n=15), while Patient 14 was confi ned to zone IV. abstract: BACKGROUND: In 2015, a large outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection occurred following a single patient exposure in an emergency room at the Samsung Medical Center, a tertiary-care hospital in Seoul, South Korea. We aimed to investigate the epidemiology of MERS-CoV outbreak in our hospital. METHODS: We identified all patients and health-care workers who had been in the emergency room with the index case between May 27 and May 29, 2015. Patients were categorised on the basis of their exposure in the emergency room: in the same zone as the index case (group A), in different zones except for overlap at the registration area or the radiology suite (group B), and in different zones (group C). We documented cases of MERS-CoV infection, confirmed by real-time PCR testing of sputum samples. We analysed attack rates, incubation periods of the virus, and risk factors for transmission. FINDINGS: 675 patients and 218 health-care workers were identified as contacts. MERS-CoV infection was confirmed in 82 individuals (33 patients, eight health-care workers, and 41 visitors). The attack rate was highest in group A (20% [23/117] vs 5% [3/58] in group B vs 1% [4/500] in group C; p<0·0001), and was 2% (5/218) in health-care workers. After excluding nine cases (because of inability to determine the date of symptom onset in six cases and lack of data from three visitors), the median incubation period was 7 days (range 2–17, IQR 5–10). The median incubation period was significantly shorter in group A than in group C (5 days [IQR 4–8] vs 11 days [6–12]; p<0·0001). There were no confirmed cases in patients and visitors who visited the emergency room on May 29 and who were exposed only to potentially contaminated environment without direct contact with the index case. The main risk factor for transmission of MERS-CoV was the location of exposure. INTERPRETATION: Our results showed increased transmission potential of MERS-CoV from a single patient in an overcrowded emergency room and provide compelling evidence that health-care facilities worldwide need to be prepared for emerging infectious diseases. FUNDING: None. url: https://www.sciencedirect.com/science/article/pii/S0140673616306237 doi: 10.1016/s0140-6736(16)30623-7 id: cord-348130-t9tysvr8 author: Cho, Sung-Yeon title: Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea date: 2018-02-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Hematopoietic stem cell transplantation (HSCT) is a treatment for hematologic malignancies, immune deficiencies, or genetic diseases, ect. Recently, the number of HSCTs performed in Korea has increased and the outcomes have improved. However, infectious complications account for most of the morbidity and mortality after HSCT. Post-HSCT infectious complications are usually classified according to the time after HSCT: pre-engraftment, immediate post-engraftment, and late post-engraftment period. In addition, the types and risk factors of infectious complications differ according to the stem cell source, donor type, conditioning intensity, region, prophylaxis strategy, and comorbidities, such as graft-versushost disease and invasive fungal infection. In this review, we summarize infectious complications after HSCT, focusing on the Korean perspectives. url: https://doi.org/10.3904/kjim.2018.036 doi: 10.3904/kjim.2018.036 id: cord-306092-5bi2q3jj author: Choi, Hee Joung title: Relationship between the Clinical Characteristics and Intervention Scores of Infants with Apparent Life-threatening Events date: 2015-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We investigated the clinical presentations, diagnostic and therapeutic modalities, and prognosis from follow-up of infants with apparent life-threatening events (ALTE). In addition, the relationship between the clinical characteristics of patients and significant intervention scores was analyzed. We enrolled patients younger than 12 months who were diagnosed with ALTE from January 2005 to December 2012. There were 29 ALTE infants with a peak incidence of age younger than 1 month (48.3%). The most common symptoms for ALTE diagnosis were apnea (69.0%) and color change (58.6%). Eleven patients appeared normal upon arrival at hospital but 2 patients required cardiopulmonary resuscitation during the initial ALTE. The most common ALTE cause was respiratory disease, including respiratory infection and upper airway anomalies (44.8%). There were 20 cases of repeat ALTE and 2 cases of death during hospitalization. Four patients (15.4%) experienced recurrence of ALTE after discharge and 4 patients (15.4%) showed developmental abnormalities during the follow-up period. The patients with ALTE during sleep had lower significant intervention scores (P=0.015) compared to patients with ALTE during wakefulness and patients with previous respiratory symptoms had higher significant intervention scores (P=0.013) than those without previous respiratory symptoms. Although not statistically significant, there was a weak positive correlation between the patient's total ALTE criteria and total significant intervention score (Fig. 2, r=0.330, P=0.080). We recommend that all ALTE infants undergo inpatient observation and evaluations with at least 24 hr of cardiorespiratory monitoring, and should follow up at least within a month after discharge. GRAPHICAL ABSTRACT: [Image: see text] url: https://www.ncbi.nlm.nih.gov/pubmed/26028930/ doi: 10.3346/jkms.2015.30.6.763 id: cord-315188-a9pvugjt author: Choi, Min Hyuk title: Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A rapid increase in the number of patients with coronavirus disease 19 (COVID-19) may overwhelm the available medical resources. We aimed to evaluate risk factors for disease severity in the early stages of COVID-19. The cohort comprised 293 patients with COVID-19 from 5 March 2020, to 18 March 2020. The Korea Centers for Disease Control and Prevention (KCDC) classification system was used to triage patients. The clinical course was summarized, including the impact of drugs (angiotensin II receptor blockers [ARB], ibuprofen, and dipeptidyl peptidase-4 inhibitors [DPP4i]) and the therapeutic effect of lopinavir/ritonavir. After adjusting for confounding variables, prior history of drug use, including ARB, ibuprofen, and DPP4i was not a risk factor associated with disease progression. Patients treated with lopinavir/ritonavir had significantly shorter progression-free survival than those not receiving lopinavir/ritonavir. KCDC classification I clearly distinguished the improvement/stabilization group from the progression group of COVID-19 patients (AUC 0.817; 95% CI, 0.740–0.895). url: https://doi.org/10.3390/jcm9061959 doi: 10.3390/jcm9061959 id: cord-276592-dsilwfl1 author: Chou, Calvin L title: How COVID-19 Disrupts—and Enhances—My Clinical Work date: 2020-04-08 words: 1381.0 sentences: 72.0 pages: flesch: 61.0 cache: ./cache/cord-276592-dsilwfl1.txt txt: ./txt/cord-276592-dsilwfl1.txt summary: Now, in this new era of attention to hand hygiene and social distancing, I paranoically and abashedly attempt to reproduce the sterile technique I learned from my days in the basic science lab, expanding my alcohol wiping to doorknobs and surfaces throughout the medical center-indeed, to any possible hideout of renegade coronavirus. I have to remind myself to begin each virtual encounter with a warm hello, an explicitly stated wish that we could be meeting in person, a sound and lighting check, and a brief check-in with the patient about how they are coping with current public health recommendations. With this intentional centering, which takes a bit more effort than usual, I can hear that most of my patients describe anxiety about what they could or should do, and this response leads to prioritizing that concern on the list of topics that we collaboratively generate. He assents, and I ask, "What do you know of social distancing?" He says, "To tell you the truth, it doesn''t make a lot of sense. abstract: nan url: https://doi.org/10.1177/2374373520918739 doi: 10.1177/2374373520918739 id: cord-263064-n4c0m5hn author: Choudhury, Ivana title: COVID-19 as a Possible Cause of Functional Exhaustion of CD4 and CD8 T-cells and Persistent Cause of Methicillin-Sensitive Staphylococcus aureus Bacteremia date: 2020-07-04 words: 2242.0 sentences: 117.0 pages: flesch: 42.0 cache: ./cache/cord-263064-n4c0m5hn.txt txt: ./txt/cord-263064-n4c0m5hn.txt summary: We report a case of a 73-year-old male with a history of diabetes mellitus, osteomyelitis, methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia who recently completed an extended intravenous course of cefazolin eight days back, and presented with MSSA bacteremia complicated by epidural abscess, endocarditis, and aortic root abscess. A 73-year-old male recently treated for methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia secondary to presumed source of non-healing diabetic foot ulcer (completed a six weeks course of intravenous (IV) cefazolin eight days ago, negative transesophageal echocardiogram (TEE)) presented to our emergency department with lower back pain with extension to the left flank region, urinary incontinence, and an altered mental status. For a patient with MSSA bacteremia and COVID-19, such as ours, CD4 and CD8 Tcell functional exhaustion may be why our patient required an extended course of IV antibiotic therapy. Our patient presented with a recurrent and persistent MSSA bacteremia and osteomyelitis, complicated by a spinal epidural abscess, bioprosthetic valve endocarditis and aortic root abscess despite appropriate antibiotic therapy. abstract: We report a case of a 73-year-old male with a history of diabetes mellitus, osteomyelitis, methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia who recently completed an extended intravenous course of cefazolin eight days back, and presented with MSSA bacteremia complicated by epidural abscess, endocarditis, and aortic root abscess. Meanwhile, the patient was tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcription-polymerase chain reaction (RT-PCR). Even with aggressive antibiotic treatment, the patient remained bacteremic and developed endocarditis with a worsening aortic root abscess. We suspect coronavirus disease 2019 (COVID-19) as a cause for the infectious paradox and will discuss the possible mechanisms in this case report. url: https://doi.org/10.7759/cureus.9000 doi: 10.7759/cureus.9000 id: cord-339811-dms0rlmr author: Choudhury, Noura title: Training Oncologists in the Time of COVID‐19 date: 2020-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In this commentary, the authors explore the short‐ and long‐term challenges of balancing education and oncologic care from the epicenter of the COVID‐19 pandemic. Once local conditions allow for resumption of outpatient care, the authors discuss how now is an especially important time to prioritize educating trainees. url: https://doi.org/10.1634/theoncologist.2020-0373 doi: 10.1634/theoncologist.2020-0373 id: cord-007321-7gi6xrci author: Chow, Anthony W. title: Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections date: 1992-11-17 words: 16053.0 sentences: 825.0 pages: flesch: 31.0 cache: ./cache/cord-007321-7gi6xrci.txt txt: ./txt/cord-007321-7gi6xrci.txt summary: These guidelines for the evaluation of drugs for the treatment of respiratory tract infections include acute streptococcal pharyngitis and tonsillitis, acute otitis media, acute and chronic sinusitis, acute exacerbations of chronic bronchitis, and acute infectious pneumonia (table 1). This is often the case in otitis media, sinusitis, and pneumonia, when the use of invasive procedures such as tympanocentesis, sinus puncture, or transtracheal aspiration to confirm microbial eradication in the patient who is improving clinically generally is considered unjustified. Patients eligible for study entrance are children or adults with symptomatic pharyngitis or tonsillitis of acute onset clinically consistent with infection with group A I3-hemolytic streptococci and from whom group A (3-hemolytic streptococci have been isolated in cultures of throat -swab specimen or for whom a rapid screening test has indicated the presence of streptococci. abstract: These guidelines deal with the evaluation of anti-infective drugs for the treatment of respiratory tract infections. Five clinical entities are described: streptococcal pharyngitis and tonsillitis, otitis media, sinusitis, bronchitis, and pneumonia. A wide variety of microorganisms are potentially pathogenetic in these diseases; these guidelines focus on the bacterial infections. Inclusion of a patient in a trial of a new drug is based on the clinical entity, with the requirement that a reasonable attempt will be made to establish a specific microbial etiology. Microbiologic evaluation of efficacy requires isolation of the pathogen and testing for in vitro susceptibility. Alternatively, surrogate markers may be used to identify the etiologic agent. The efficacy of new drugs is evaluated with reference to anticipated response rates. Establishment of the microbial etiology of respiratory tract infections is hampered by the presence of “normal flora” of the nose, mouth, and pharynx, which may include asymptomatic carriage of potential pathogens. This issue is addressed for each category of infection described. For example, it is suggested that for initial phase 2 trials of acute otitis media and acute sinusitis tympanocentesis or direct sinus puncture be used to collect exudate for culture. Acute exacerbations of chronic bronchitis also present difficulties in the establishment of microbial etiology. These guidelines suggest that clinical trials employ an active control drug but leave open the possibility of a placebo-controlled trial. For pneumonia, the guidelines suggest the identification and enrollment of patients by the clinical type of pneumonia, e.g., atypical pneumonia or acute bacterial pneumonia, rather than by etiologic organism or according to whether it was community or hospital acquired. For each respiratory infection, the clinical response is judged as cure, failure, or indeterminate. Clinical improvement is not acceptable unless quantitative response measures can be applied. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110372/ doi: 10.1093/clind/15.supplement_1.s62 id: cord-253148-3t4o27xp author: Chow, Brian D.W. title: Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio date: 2008-09-19 words: 2700.0 sentences: 200.0 pages: flesch: 50.0 cache: ./cache/cord-253148-3t4o27xp.txt txt: ./txt/cord-253148-3t4o27xp.txt summary: STUDY DESIGN: From October 2005 through October 2006, we screened respiratory samples from children and adults negative for common respiratory pathogens for HBoV by PCR. CONCLUSIONS: HBoV circulates in Cleveland, OH, in children and adults with similar frequencies, and can warrant hospitalization and intensive care. We sought to further define the clinical and epidemiologic characteristics of HBoV in adult and pediatric patients in Cleveland, OH. Isolates positive for HBoV were screened for common respiratory viruses by RT-PCR with published primer sets. Forty samples (2.2%) tested positive for HBoV by PCR: 36 (90%) pediatric patients and 4 (10%) adult patients. Of pediatric patients who screened positive for HBoV, 27 (84.4%) were admitted to the hospital, including 9 (28.1%) who required intensive care. However, this report suggests that clinical disease associated with HBoV alone may be severe enough to require admission to the hospital in both adults and children and to the intensive care unit in children. abstract: BACKGROUND: Viral respiratory illness is a major cause of morbidity and mortality. The human bocavirus (HBoV) is a recently recognized parvovirus isolated from human respiratory secretions. OBJECTIVES: To define the clinical and epidemiologic characteristics in adult and pediatric patients with evidence of HBoV. STUDY DESIGN: From October 2005 through October 2006, we screened respiratory samples from children and adults negative for common respiratory pathogens for HBoV by PCR. Demographic and clinical characteristics were obtained from medical records of HBoV positive individuals. RESULTS: Of 2075 samples screened, 1826 (88.0%) represented distinct respiratory events: 1539 (84.3%) were pediatric (<18 years), and 273 (15.0%) adult (≥18 years). Forty (2.2%) patients had HBoV: 36 (2.3%) children and 4 (1.5%) adults. HBoV positive children had history of prematurity (31.3%) and cardiac disease (18.8%). Adults had underlying pulmonary (100%) and cardiac (50%) disease. Twenty-seven children (84.4%) were hospitalized; 9 (28.1%) required intensive care. All adults were hospitalized; none required intensive care. Nosocomial acquisition likely occurred in 3 patients. CONCLUSIONS: HBoV circulates in Cleveland, OH, in children and adults with similar frequencies, and can warrant hospitalization and intensive care. Further study would clarify our understanding of this newly recognized human pathogen. url: https://www.ncbi.nlm.nih.gov/pubmed/18805051/ doi: 10.1016/j.jcv.2008.07.009 id: cord-348755-2g5gi1du author: Chow, D. S. title: Development and External Validation of a Prognostic Tool for COVID-19 Critical Disease date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: The rapid spread of coronavirus disease 2019 (COVID-19) revealed significant constraints in critical care capacity. In anticipation of subsequent waves, reliable prediction of disease severity is essential for critical care capacity management and may enable earlier targeted interventions to improve patient outcomes. The purpose of this study is to develop and externally validate a prognostic model/clinical tool for predicting COVID-19 critical disease at presentation to medical care. Methods: This is a retrospective study of a prognostic model for the prediction of COVID-19 critical disease where critical disease was defined as ICU admission, ventilation, and/or death. The derivation cohort was used to develop a multivariable logistic regression model. Covariates included patient comorbidities, presenting vital signs, and laboratory values. Model performance was assessed on the validation cohort by concordance statistics. The model was developed with consecutive patients with COVID-19 who presented to University of California Irvine Medical Center in Orange County, California. External validation was performed with a random sample of patients with COVID-19 at Emory Healthcare in Atlanta, Georgia. Results: Of a total 3208 patients tested in the derivation cohort, 9% (299/3028) were positive for COVID-19. Clinical data including past medical history and presenting laboratory values were available for 29% (87/299) of patients (median age, 48 years [range, 21-88 years]; 64% [36/55] male). The most common comorbidities included obesity (37%, 31/87), hypertension (37%, 32/87), and diabetes (24%, 24/87). Critical disease was present in 24% (21/87). After backward stepwise selection, the following factors were associated with greatest increased risk of critical disease: number of comorbidities, body mass index, respiratory rate, white blood cell count, % lymphocytes, serum creatinine, lactate dehydrogenase, high sensitivity troponin I, ferritin, procalcitonin, and C-reactive protein. Of a total of 40 patients in the validation cohort (median age, 60 years [range, 27-88 years]; 55% [22/40] male), critical disease was present in 65% (26/40). Model discrimination in the validation cohort was high (concordance statistic: 0.94, 95% confidence interval 0.87-1.01). A web-based tool was developed to enable clinicians to input patient data and view likelihood of critical disease. Conclusions and Relevance: We present a model which accurately predicted COVID-19 critical disease risk using comorbidities and presenting vital signs and laboratory values, on derivation and validation cohorts from two different institutions. If further validated on additional cohorts of patients, this model/clinical tool may provide useful prognostication of critical care needs. url: https://doi.org/10.1101/2020.05.06.20093435 doi: 10.1101/2020.05.06.20093435 id: cord-003701-i70ztypg author: Chow, Eric J. title: Influenza virus-related critical illness: prevention, diagnosis, treatment date: 2019-06-12 words: 6869.0 sentences: 320.0 pages: flesch: 25.0 cache: ./cache/cord-003701-i70ztypg.txt txt: ./txt/cord-003701-i70ztypg.txt summary: Based upon observational data that suggest harms, adjunctive corticosteroid treatment is currently not recommended for children or adults hospitalized with influenza, including critically ill patients, unless clinically indicated for another reason, such as treatment of asthma or COPD exacerbation, or septic shock. No completed randomized, placebo-controlled trials of antiviral treatment have been conducted in hospitalized influenza patients to establish the efficacy of oseltamivir or other NAIs. A number of observational studies have reported clinical benefit of neuraminidase inhibitors in hospitalized patients, including reduction in duration of hospitalization and risk of death, including in ICU patients [67] [68] [69] [70] [71] [72] [73] [74] . A cohort study of early versus late oseltamivir treatment reported a significant reduction in mortality and median duration of ICU hospitalization in severely ill patients with influenza A(H3N2), but not A(H1N1pdm09) or B virus infection in Greece [78] . abstract: Annual seasonal influenza epidemics of variable severity result in significant morbidity and mortality in the United States (U.S.) and worldwide. In temperate climate countries, including the U.S., influenza activity peaks during the winter months. Annual influenza vaccination is recommended for all persons in the U.S. aged 6 months and older, and among those at increased risk for influenza-related complications in other parts of the world (e.g. young children, elderly). Observational studies have reported effectiveness of influenza vaccination to reduce the risks of severe disease requiring hospitalization, intensive care unit admission, and death. A diagnosis of influenza should be considered in critically ill patients admitted with complications such as exacerbation of underlying chronic comorbidities, community-acquired pneumonia, and respiratory failure during influenza season. Molecular tests are recommended for influenza testing of respiratory specimens in hospitalized patients. Antigen detection assays are not recommended in critically ill patients because of lower sensitivity; negative results of these tests should not be used to make clinical decisions, and respiratory specimens should be tested for influenza by molecular assays. Because critically ill patients with lower respiratory tract disease may have cleared influenza virus in the upper respiratory tract, but have prolonged influenza viral replication in the lower respiratory tract, an endotracheal aspirate (preferentially) or bronchoalveolar lavage fluid specimen (if collected for other diagnostic purposes) should be tested by molecular assay for detection of influenza viruses. Observational studies have reported that antiviral treatment of critically ill adult influenza patients with a neuraminidase inhibitor is associated with survival benefit. Since earlier initiation of antiviral treatment is associated with the greatest clinical benefit, standard-dose oseltamivir (75 mg twice daily in adults) for enteric administration is recommended as soon as possible as it is well absorbed in critically ill patients. Based upon observational data that suggest harms, adjunctive corticosteroid treatment is currently not recommended for children or adults hospitalized with influenza, including critically ill patients, unless clinically indicated for another reason, such as treatment of asthma or COPD exacerbation, or septic shock. A number of pharmaceutical agents are in development for treatment of severe influenza. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563376/ doi: 10.1186/s13054-019-2491-9 id: cord-352937-htmp0avc author: Chow, Velda Ling Yu title: Recommendations for surgical management of recurrent nasopharyngeal carcinoma during COVID‐19 pandemic date: 2020-06-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Nasopharyngeal carcinoma is endemic in southern parts of China including Hong Kong. Primary treatment entails radiotherapy ± chemotherapy depending on disease stage at presentation. Surgery is offered as a means of salvage for persistent and recurrent disease. Comprehensive preoperative work‐up, careful patient selection, attention to details perioperation and multidisciplinary approach is essential in ensuring optimal outcomes after salvage surgery for recurrent nasopharyngeal carcinoma patients. Since the COVID‐19 outbreak, we are faced with unprecedented challenges with priorities of care and resources being shifted to combat the virus. These include patient selection and timing of treatment, while preventing disease transmission to heath care providers. Practices and recommendations made in this document are intended to support safe clinical practice and efficient use of resources during this challenging time. url: https://www.ncbi.nlm.nih.gov/pubmed/32596489/ doi: 10.1002/lio2.417 id: cord-204125-fvd6d44c author: Chowdhury, Muhammad E. H. title: An early warning tool for predicting mortality risk of COVID-19 patients using machine learning date: 2020-07-29 words: 3883.0 sentences: 199.0 pages: flesch: 47.0 cache: ./cache/cord-204125-fvd6d44c.txt txt: ./txt/cord-204125-fvd6d44c.txt summary: Lactate dehydrogenase, neutrophils (%), lymphocyte (%), high sensitive C-reactive protein, and age acquired at hospital admission were identified as key predictors of death by multi-tree XGBoost model. The prognostic model, nomogram and LNLCA score can help in early detection of high mortality risk of COVID-19 patients, which will help doctors to improve the management of patient stratification. [21] reported a machine learning approach to select three biomarkers (lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP)) and using them to predict individual patients mortality, 10 days ahead with more than 90 percent accuracy. Although several predictive prognostic models are proposed for the early detection of individuals at high risk of COVID-19 mortality, a major gap remains in the design of state-of-the-art interpretable machine learning based algorithms and high performance quantitative scoring system to classify the most selective predictive biomarkers of patient death. abstract: COVID-19 pandemic has created an extreme pressure on the global healthcare services. Fast, reliable and early clinical assessment of the severity of the disease can help in allocating and prioritizing resources to reduce mortality. In order to study the important blood biomarkers for predicting disease mortality, a retrospective study was conducted on 375 COVID-19 positive patients admitted to Tongji Hospital (China) from January 10 to February 18, 2020. Demographic and clinical characteristics, and patient outcomes were investigated using machine learning tools to identify key biomarkers to predict the mortality of individual patient. A nomogram was developed for predicting the mortality risk among COVID-19 patients. Lactate dehydrogenase, neutrophils (%), lymphocyte (%), high sensitive C-reactive protein, and age - acquired at hospital admission were identified as key predictors of death by multi-tree XGBoost model. The area under curve (AUC) of the nomogram for the derivation and validation cohort were 0.961 and 0.991, respectively. An integrated score (LNLCA) was calculated with the corresponding death probability. COVID-19 patients were divided into three subgroups: low-, moderate- and high-risk groups using LNLCA cut-off values of 10.4 and 12.65 with the death probability less than 5%, 5% to 50%, and above 50%, respectively. The prognostic model, nomogram and LNLCA score can help in early detection of high mortality risk of COVID-19 patients, which will help doctors to improve the management of patient stratification. url: https://arxiv.org/pdf/2007.15559v1.pdf doi: nan id: cord-325421-1ysn0kyr author: Christensen, Johanna title: Covid-19 Viremia, Serologies and Clinical Course in a Case Series of Transplant Recipients date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Here we report a single-center cohort of 6 patients (4 kidney-only, and 2 simultaneous liver/kidney transplants) diagnosed with COVID-19 at a median of 1.9 years (range=0.2-9.3 years) post-transplant. Five (of 6) patients required inpatient admission, two patients (mortality=33%) died. Among those with mortality, an increased concentration of inflammatory biomarkers [interleukin-6 (IL6) and C-reactive protein] was noted with a lack of response to IL-6 blockade, remdesivir and/or convalescent plasma. None of the kidney-only transplants (4/6; 67%) had elevation in plasma donor-derived cell-free DNA above the previously published cut-off of 1% suggesting absence of significant allo-immune injury. Four (of 5) admitted patients had detectable SARS-CoV-2 (severe acute respiratory syndrome–coronavirus 2) in blood on samples obtained at/during hospitalization. Of the 4 discharged patients, two patients with undetectable virus on repeat nasopharyngeal swabs had seroconversion with positive SARS-CoV-2 IgG formation at 30-48 days post-infection. One patient had prolonged shedding of virus on nasopharyngeal swab at 28 days post-discharge despite lack of symptoms. In this preliminary report, we find that immunocompromised transplant patients had higher rates of RNAemia (67%) than reported in the general population (15%), seeming absence of allo-immune injury despite systemic inflammation and formation of IgG overtime after recovery from infection. url: https://doi.org/10.1016/j.transproceed.2020.08.042 doi: 10.1016/j.transproceed.2020.08.042 id: cord-033965-c1i7dnnt author: Christian, Ashton B. title: Comparison of surgical fixation and non-operative management in patients with traumatic sternum fracture date: 2020-10-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: The incidence of sternal fractures in blunt trauma patients lies between 3 and 7%. The role, timing and indications for surgical management are not well delineated and remain controversial for patients undergoing surgical stabilization of sternum fracture (SSSF). We sought to identify the national rate of SSSF in patients with a sternum fracture hypothesizing patients undergoing SSSF will have a decreased rate of mortality and complications. METHODS: The Trauma Quality Improvement Program (2015–2016) was queried for patients with sternum fracture. Propensity scores were calculated to match patients undergoing SSSF to patients managed non-operatively in a 1:2 ratio using demographic data. RESULTS: From 9460 patients with a sternum fracture, 114 (1.2%) underwent SSSF. After propensity-matching, 112 SSSF patients were compared to 224 patients undergoing non-operative management (NOM). There were no differences in matched characteristics (all p > 0.05). Compared to patients undergoing NOM, patients undergoing SSSF had an increased median length of stay (LOS) (16 vs. 7 days, p < 0.001), ICU LOS (9.5 vs. 5.5 days, p = 0.016) and ventilator days (8 vs. 5, p = 0.035). The SSSF group had a similar rate of ARDS (2.7% vs. 2.2%, p = 0.80), pneumonia (1.8% vs. 0.9%, p = 0.48) and unplanned intubation (8.9% vs. 5.8%, p = 0.29) but a lower mortality rate (2.7% vs. 11.2%, p = 0.008). CONCLUSION: Just over 1% of patients with sternum fracture underwent SSSF in a national analysis. Patients undergoing SSSF had an increased LOS and similar rate of all measured pulmonary complications, however a lower mortality rate compared to patients managed non-operatively. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571865/ doi: 10.1007/s00068-020-01527-6 id: cord-353059-39msyuxb author: Chroboczek, T. title: Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis. date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for Coronavirus Disease 2019 (COVID-19), is spreading worldwide, causing significant morbidity and mortality. No specific treatment has yet clearly shown to improve the disease's evolution. Validated therapeutic options are urgently needed. Methods. In this retrospective study, we aimed to evaluate determinants of the prognosis of the disease in 70 patients with COVID-19 severe pneumonia (i.e. requiring at least 3 liters of oxygen) hospitalized between 10 March and 9 April, 2020, in the Centre Hospitalier Alpes Leman, France. The main outcome was oro-tracheal intubation and the exposure of interest was corticotherapy. Since this was not a randomized trial, we used propensity score matching to estimate average treatment effect. Results. There was evidence that corticotherapy lowered the risk of intubation with a risk difference of -47.1% (95% confidence interval -71.8% to -22.5%). Conclusion. Corticosteroid, a well-known, easily available, and cheap treatment, could be an important tool in management of severe COVID-19 patients with respiratory failure. Not only could it provide an individual benefit, but also, in the setting of the COVID-19 ongoing pandemic, lower the burden on our vulnerable healthcare systems. url: https://doi.org/10.1101/2020.05.08.20094755 doi: 10.1101/2020.05.08.20094755 id: cord-294079-px9c20il author: Chua, Horng-Ruey title: Ensuring Sustainability of Continuous Kidney Replacement Therapy in the Face of Extraordinary Demand: Lessons From the COVID-19 Pandemic date: 2020-06-04 words: 3928.0 sentences: 200.0 pages: flesch: 38.0 cache: ./cache/cord-294079-px9c20il.txt txt: ./txt/cord-294079-px9c20il.txt summary: Consumption of CKRT resources can be made more efficient by optimizing circuit anticoagulation to preserve filters, extending use of each vascular access, lowering blood flows to reduce citrate consumption, moderating the CKRT intensity to conserve fluids, or running accelerated KRT at higher clearance to treat more patients per machine. Specifically, we aimed to: (i) develop projections regarding the demand for CKRT that are revised weekly in accordance with prevailing rates; (ii) improve efficiency of existing care practices to avoid future rationing; (iii) optimize stocks of consumables by trimming current consumption and diversifying sources, while preventing hoarding; (iv) ramp up clinical and nursing training but maintain realistic workforce awareness; and most importantly, (v) collaborate widely at a national and regional level, and stay in close communication despite the social disconnect forced by COVID-19 (Fig.1) . abstract: With the exponential surge in coronavirus disease 2019 (COVID-19) patients worldwide, the resources needed to provide continuous kidney replacement therapy (CKRT) for patients with acute kidney injury or kidney failure may be threatened. This article summarizes subsisting strategies that can be implemented immediately. Pre-emptive weekly multi-center projections of CKRT demand based on evolving COVID-19 epidemiology and routine workload should be made. Corresponding consumables should be quantified and acquired, with diversification of sources from multiple vendors. Supply procurement should be stepped up accordingly, so that a several-week stock is amassed, with administrative oversight to prevent disproportionate hoarding by institutions. Consumption of CKRT resources can be made more efficient by optimizing circuit anticoagulation to preserve filters, extending use of each vascular access, lowering blood flows to reduce citrate consumption, moderating the CKRT intensity to conserve fluids, or running accelerated KRT at higher clearance to treat more patients per machine. If logistically feasible, earlier transition to intermittent hemodialysis with online generated dialysate, or urgent peritoneal dialysis in selected patients, may help reduce CKRT dependency. These measures, coupled to multi-center collaboration and a corresponding increase in trained medical and nursing staffing levels, may avoid downstream rationing of care and save lives during the peak of the pandemic. url: https://doi.org/10.1053/j.ajkd.2020.05.008 doi: 10.1053/j.ajkd.2020.05.008 id: cord-277498-hdhq99k2 author: Chua, Melvin L.K. title: Follow-up and management of head and neck cancer patients during the 2019 novel coronavirus (SARS-CoV-2) disease pandemic date: 2020-05-15 words: 3345.0 sentences: 158.0 pages: flesch: 45.0 cache: ./cache/cord-277498-hdhq99k2.txt txt: ./txt/cord-277498-hdhq99k2.txt summary: title: Follow-up and management of head and neck cancer patients during the 2019 novel coronavirus (SARS-CoV-2) disease pandemic These scenarios would be considered high-risk for SARS-CoV-2 transmission, and the HCW consulting the patient would require full personal protection equipment (PPE) consisting of N95 mask, surgical gowns, gloves, and goggles/face shields 16 . Following the completion of treatment any patient with direct contact with a SARS-CoV-2 infected individual or who has personally tested positive or has symptoms of COVID-19 should not be seen in an oncology clinic for a follow-up visit. When it is challenging to distinguish between post-treatment edema and residual tumor on imaging, a detailed physical exam including endoscopy may be required, and as aforementioned, full PPE is required to protect the HCW from transmission of SARS-CoV-2 through aerosolization during NPL. Herein, we focused on the impact of this pandemic on the management of head and neck cancer patients who are undergoing or have completed radiation treatment. abstract: The SARS-CoV-2 pandemic has significantly impacted healthcare delivery around the world. Elective procedures and routine follow-ups have been cancelled and/or converted to tele-health visits by many systems. In this article, we focus on recommendations for the surveillance of head and neck cancer patients during and following radiotherapy treatment. We synthesized information from clinical evidence, existing recommendations from the NCCN, and variations in practice between multiple academic tertiary cancer centers to develop the proposed guidance. url: https://www.ncbi.nlm.nih.gov/pubmed/32426556/ doi: 10.1016/j.adro.2020.04.031 id: cord-311275-ysr9nqun author: Chuaychoo, Benjamas title: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients date: 2019-07-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Respiratory syncytial virus (RSV) is an important virus found in adult hospitalized patients. OBJECTIVES: To study the clinical outcomes of hospitalized patients aged ≥ 15 years and diagnosed with RSV infection. STUDY DESIGN: Both retrospective and prospective cohort studies were conducted at a university hospital between May 2014 and December 2015. Results: RSV was detected in 86 of 1562(5.5%) adult hospitalized patients suspected of respiratory viral infection. Sixty-nine patients were included in the study. RSV was detected by RT-PCR (82.6%), IFA (10.1%), and both RT-PCR and IFA (7.3%). Most patients (87.0%) were aged ≥ 50 years. Cardiovascular diseases, pulmonary diseases, immunocompromised hosts, and diabetes were the major comorbidities. The common manifestations were cough (92.8%), dyspnea (91.3%), sputum production (87.0%), tachypnea (75.4%), wheezing (73.9%), and fever (71.0%). Fifty- five patients (79.7%) were diagnosed with pneumonia. Hypoxemia (SpO2 ≤ 92%) was found in 53.6% patients. Twenty-five of 69(36.2%) patients developed respiratory failure and required ventilatory support. Cardiovascular complications were found in 24.6% of patients. Congestive heart failure, acute myocardial infarction (MI), new atrial fibrillation, and supraventricular tachycardia were found in 9(13.0%), 7(10.1%), 4(5.8%), and 3(4.3%) of 69 patients, respectively. Overall mortality was 15.9%. Pneumonia (81.8%) and acute MI (18.2%) were the major causes of death. CONCLUSIONS: Most adult hospitalized patients with RSV infection were of advanced age and had comorbidities. Cardiopulmonary complications were the major causes of death. Management and prevention of RSV infection in these vulnerable groups are necessary. url: https://doi.org/10.1016/j.jcv.2019.07.001 doi: 10.1016/j.jcv.2019.07.001 id: cord-334212-3gqzeakb author: Chun, Tristen T. title: Phlegmasia Cerulea Dolens Associated with Acute COVID-19 Pneumonia Despite Supratherapeutic Warfarin Anticoagulation date: 2020-10-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patients with acute Coronavirus-19 (COVID-19) respiratory infections are associated with concomitant thromboembolic complications and a hypercoagulable state. Although these mechanisms are not completely understood, unique alterations in serum markers for hemostasis and thrombosis have been detected. A high index of suspicion is required by vascular surgeons in patients presenting with this novel virus. We present the case of a 51 year old male with acute COVID-19 pneumonia who developed Phlegmasia Cerulea Dolens despite chronic warfarin therapy and a supratherapeutic International Normalized Ratio (INR). url: https://api.elsevier.com/content/article/pii/S2468428720301763 doi: 10.1016/j.jvscit.2020.10.002 id: cord-333816-cznwzcn9 author: Chung, Michael title: CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) date: 2020-02-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In this retrospective case series, chest CT scans of 21 symptomatic patients from China infected with the 2019 novel coronavirus (2019-nCoV) were reviewed, with emphasis on identifying and characterizing the most common findings. Typical CT findings included bilateral pulmonary parenchymal ground-glass and consolidative pulmonary opacities, sometimes with a rounded morphology and a peripheral lung distribution. Notably, lung cavitation, discrete pulmonary nodules, pleural effusions, and lymphadenopathy were absent. Follow-up imaging in a subset of patients during the study time window often demonstrated mild or moderate progression of disease, as manifested by increasing extent and density of lung opacities. © RSNA, 2020 url: https://doi.org/10.1148/radiol.2020200230 doi: 10.1148/radiol.2020200230 id: cord-000308-cxr1ul7q author: Cianchi, Giovanni title: Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date: 2011-01-11 words: 4325.0 sentences: 239.0 pages: flesch: 42.0 cache: ./cache/cord-000308-cxr1ul7q.txt txt: ./txt/cord-000308-cxr1ul7q.txt summary: BACKGROUND: Since the first outbreak of a respiratory illness caused by H1N1 virus in Mexico, several reports have described the need of intensive care or extracorporeal membrane oxygenation (ECMO) assistance in young and often healthy patients. Since the first outbreak of a respiratory illness caused by Influenza A (H1N1) virus in Mexico [1] , several reports have described the need of intensive care [2] [3] [4] or extracorporeal membrane oxygenation (ECMO) assistance [5] in young and often healthy patients. In the present investigation we report our experience, as an ECMO referral center, in H1N1-induced acute respiratory distress syndrome (ARDS) and we present the critical care service planning in response to the H1N1 pandemic. List of abbreviations ARDS: acute respiratory distress syndrome; BMI: body mass index; CVVH: continuous veno-venous hemofiltration; ECMO: extracorporeal membrane oxygenation; ICU: intensive care unit; LOS: length of stay; LUS: lung ultrasound; RT-PCR: real-time reverse transcriptase-polymerase-chain-reaction; SAPS: simplified acute physiology score. abstract: BACKGROUND: Since the first outbreak of a respiratory illness caused by H1N1 virus in Mexico, several reports have described the need of intensive care or extracorporeal membrane oxygenation (ECMO) assistance in young and often healthy patients. Here we describe our experience in H1N1-induced ARDS using both ventilation strategy and ECMO assistance. METHODS: Following Italian Ministry of Health instructions, an Emergency Service was established at the Careggi Teaching Hospital (Florence, Italy) for the novel pandemic influenza. From Sept 09 to Jan 10, all patients admitted to our Intensive Care Unit (ICU) of the Emergency Department with ARDS due to H1N1 infection were studied. All ECMO treatments were veno-venous. H1N1 infection was confirmed by PCR assayed on pharyngeal swab, subglottic aspiration and bronchoalveolar lavage. Lung pathology was evaluated daily by lung ultrasound (LUS) examination. RESULTS: A total of 12 patients were studied: 7 underwent ECMO treatment, and 5 responded to protective mechanical ventilation. Two patients had co-infection by Legionella Pneumophila. One woman was pregnant. In our series, PCR from bronchoalveolar lavage had a 100% sensitivity compared to 75% from pharyngeal swab samples. The routine use of LUS limited the number of chest X-ray examinations and decreased transportation to radiology for CT-scan, increasing patient safety and avoiding the transitory disconnection from ventilator. No major complications occurred during ECMO treatments. In three cases, bleeding from vascular access sites due to heparin infusion required blood transfusions. Overall mortality rate was 8.3%. CONCLUSIONS: In our experience, early ECMO assistance resulted safe and feasible, considering the life threatening condition, in H1N1-induced ARDS. Lung ultrasound is an effective mean for daily assessment of ARDS patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022902/ doi: 10.1186/1471-2466-11-2 id: cord-273758-hhd8xnve author: Ciardullo, S. title: Impact of diabetes on COVID-19-related in-hospital mortality: a retrospective study from Northern Italy date: 2020-08-10 words: 3404.0 sentences: 164.0 pages: flesch: 46.0 cache: ./cache/cord-273758-hhd8xnve.txt txt: ./txt/cord-273758-hhd8xnve.txt summary: Nonetheless, it remains controversial whether diabetes could be considered an independent risk factor for greater severity of illness and death, with some studies showing a detrimental effect [5] [6] [7] and others a neutral influence [8] [9] [10] , also depending on adjustment for confounding variables. As expected, patients who experienced in-hospital death were older (78 vs 68 years, p < 0.001) and had a higher prevalence of most comorbidities including CVD (46.4% vs 32.5%, p = 0.007) and hypertension (78.1 vs 56.8%, p < 0.001), whereas only a trend was found for diabetes (23.2 vs 15.6%, p = 0.064) and no significant differences were found in gender distribution. In the present study we show that among patients hospitalized for COVID-19 in a single center in Northern Italy, a history of diabetes was associated with an increased mortality risk, which was independent from several confounding factors and comorbidities. abstract: PURPOSE: The purpose of this study was to evaluate the impact of pre-existing diabetes on in-hospital mortality in patients admitted for Coronavirus Disease 2019 (COVID-19). METHODS: This is a single center, retrospective study conducted at Policlinico di Monza hospital, located in the Lombardy region, Northern Italy. We reviewed medical records of 373 consecutive adult patients who were hospitalized with COVID-19 between February 22 and May 15, 2020. Data were collected on diabetes status, comorbid conditions and laboratory findings. Multivariable logistic regression was performed to evaluate the effect of diabetes on in-hospital mortality after adjustment for potential confounding variables. RESULTS: Mean age of the patients was 72 ± 14 years (range 17–98), 244 (65.4%) were male and 69 (18.5%) had diabetes. The most common comorbid conditions were hypertension (237 [64.8%]), cardiovascular disease (140 [37.7%]) and malignant neoplasms (50 [13.6%]). In-hospital death occurred in 142 (38.0%) patients. In the multivariable model older age (Relative Risk [RR] 1.06 [1.04–1. 09] per year), diabetes (RR 1.56 [1.05–2.02]), chronic obstructive pulmonary disease (RR 1.82 [1.13–2.35]), higher values of lactic dehydrogenase and C-reactive protein were independently associated with in-hospital mortality. CONCLUSION: In this retrospective single-center study, diabetes was independently associated with a higher in-hospital mortality. More intensive surveillance of patients with this condition is to be warranted. url: https://doi.org/10.1007/s40618-020-01382-7 doi: 10.1007/s40618-020-01382-7 id: cord-009982-zgbu46fo author: Cies, Jeffrey J. title: Peramivir for Influenza A and B Viral Infections: A Pharmacokinetic Case Series date: 2019-10-04 words: 2899.0 sentences: 167.0 pages: flesch: 40.0 cache: ./cache/cord-009982-zgbu46fo.txt txt: ./txt/cord-009982-zgbu46fo.txt summary: DESIGN: Retrospective electronic medical record review of prospectively collected data from critically ill children receiving peramivir for influenza A or B viral infections in the pediatric intensive care unit (PICU). CONCLUSION: The pharmacokinetics of PRV demonstrated in this PICU cohort differs in comparison to healthy pediatric and adult patients, and alterations to dosing regimens may be needed in PICU patients to achieve pharmacodynamic exposures. 20 The current FDA-approved pediatric dosing regimen is recommended based on pharmacokinetic data to approximate a total drug exposure or AUC similar to that achieved in adults that was associated with safety and efficacy. 3 The pharmacokinetic data from these 11 PICU patients suggest that dosing modifications would be needed for PRV to better achieve drug exposures similar to those described earlier 3 and in the PI. abstract: OBJECTIVE: To describe the peramivir (PRV) pharmacokinetics in critically ill children treated for influenza A or B viral infections. DESIGN: Retrospective electronic medical record review of prospectively collected data from critically ill children receiving peramivir for influenza A or B viral infections in the pediatric intensive care unit (PICU). SETTING: A 189‐bed, freestanding children's tertiary care teaching hospital in Philadelphia, PA. PATIENTS: Critically ill children admitted to the PICU who were infected with influenza between January 1, 2016 and March 31, 2018. INTERVENTIONS: None. RESULTS: Eleven patients, two females (18%) and nine males (82%), accounted for 24 peramivir samples for therapeutic drug management. The median age was 5 years (interquartile range 1.5–6.5 yrs) with a median weight of 16.4 kg (interquartile range 14–24 kg). Ten (91%) patients demonstrated a larger volume of distribution, 11 (100%) patients demonstrated an increase in clearance, and 11 (100%) patients demonstrated a shorter half‐life estimate as compared with the package insert and previous pediatric trial data for peramivir. Eight (73%) patients tested positive for a strain of influenza A and 3 (27%) patients tested positive for influenza B; 4 of 11 (36%) patients tested positive for multiple viruses. All patients had adjustments made to their dosing interval to a more frequent interval. Ten (91%) patients were adjusted to an every‐12‐hour regimen and 1 (9%) patient was adjusted to an every‐8‐hour regimen. No adverse events were associated with peramivir treatment. CONCLUSION: The pharmacokinetics of PRV demonstrated in this PICU cohort differs in comparison to healthy pediatric and adult patients, and alterations to dosing regimens may be needed in PICU patients to achieve pharmacodynamic exposures. Additional investigations in the PICU population are needed to confirm these findings. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167779/ doi: 10.1002/phar.2330 id: cord-331915-7idktu7c author: Cieslak, Theodore J title: A Brief History of Biocontainment date: 2016-10-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The concept of clinical biocontainment, otherwise known as high-level containment care (HLCC), had its birth among a confluence of near-simultaneous events in 1969. The U.S. Army’s Medical Research Institute of Infectious Diseases (USAMRIID) began construction of the first modern biocontainment unit that year, and opened the two-bed facility, often referred to as “the Slammer” in 1971. Over its 41-year existence, 21 persons exposed to highly hazardous infectious diseases were admitted to the Slammer, but none ever contracted the disease to which they had been exposed. Owing, in part, to this underutilization, some questioned the utility of HLCC units. This concern notwithstanding, Emory University and the University of Nebraska opened HLCC units in civilian academic medical centers in 2004 and 2005, respectively. These units, distinct from conventional infectious disease isolation wards found in most major medical centers, proved their worth during the West African Ebola Virus Disease (EVD) outbreak of 2014–2015. It is our opinion that such units, as well as the parallel high-level containment transport systems necessary to move patients to them, will continue to play an important role in the global response to emerging and highly hazardous contagious pathogens. Moreover, we feel that the lessons derived from their successful operation will lead to improvements in infection control procedures and practices throughout the healthcare system. url: https://www.ncbi.nlm.nih.gov/pubmed/32226328/ doi: 10.1007/s40506-016-0096-2 id: cord-350589-h6hotlqk author: Cieszanowski, Andrzej title: Management of patients with COVID-19 in radiology departments, and indications regarding imaging studies – recommendations of the Polish Medical Society of Radiology date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The pandemic involving COVID-19 caused by the SARS-CoV-2 coronavirus, due to its severe symptoms and high transmission rate, has gone on to pose a control challenge for healthcare systems all around the world. We present the second version of the Recommendations of the Polish Medical Society of Radiology, presuming that our knowledge on COVID-19 will advance further rapidly, to the extent that further supplementation and modification will prove necessary. These Recommendations involve rules of conduct, procedures, and safety measures that should be introduced in radiology departments, as well as indications for imaging studies. url: https://doi.org/10.5114/pjr.2020.95022 doi: 10.5114/pjr.2020.95022 id: cord-294933-oc2glu4a author: Cinesi Gómez, César title: Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection date: 2020-06-19 words: 5643.0 sentences: 337.0 pages: flesch: 45.0 cache: ./cache/cord-294933-oc2glu4a.txt txt: ./txt/cord-294933-oc2glu4a.txt summary: The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. The present document has been developed by consensus among the scientific societies involved in acute respiratory failure in adult patients, and seeks to provide a more detailed description of the recommendations on the use of non-invasive respiratory support (NIRS) in the management of acute respiratory failure (ARF) secondary to infection by the newly emergent SARS-CoV-2 coronavirus, which causes so-called COVID-19 disease, as a complement to the information emitted by the Spanish Ministry of Health, Consumer Affairs and Social Wellbeing (Ministerio de Sanidad, Consumo y Bienestar Social [MSC]), 1,2 which is frequently updated and establishes a series of general recommendations. abstract: Abstract Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, that was first recognized in Wuhan, China, in December 2019. Currently, the World Health Organization (WHO) has defined the infection as a global pandemic and there is a health and social emergency for the management of this new infection. While most people with COVID-19 develop only mild or uncomplicated illness, approximately 14% develop severe disease that requires hospitalization and oxygen support, and 5% require admission to an intensive care unit. In severe cases, COVID-19 can be complicated by the acute respiratory distress syndrome (ARDS), sepsis and septic shock, and multiorgan failure. This consensus document has been prepared on evidence-informed guidelines developed by a multidisciplinary panel of health care providers from four Spanish scientific societies (Spanish Society of Intensive Care Medicine [SEMICYUC], Spanish Society of Pulmonologists [SEPAR], Spanish Society of Emergency [SEMES], Spanish Society of Anesthesiology, Reanimation, and Pain [SEDAR]) with experience in the clinical management of patients with COVID-19 and other viral infections, including SARS, as well as sepsis and ARDS. The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. This consensus guidance should serve as a foundation for optimized supportive care to ensure the best possible chance for survival and to allow for reliable comparison of investigational therapeutic interventions as part of randomized controlled trials. url: https://www.sciencedirect.com/science/article/pii/S217357272030120X doi: 10.1016/j.medine.2020.03.002 id: cord-294371-xot2oj2t author: Citgez, Bulent title: Management of Breast Cancer during the COVID-19 Pandemic date: 2020-06-10 words: 2222.0 sentences: 130.0 pages: flesch: 49.0 cache: ./cache/cord-294371-xot2oj2t.txt txt: ./txt/cord-294371-xot2oj2t.txt summary: In this review, we tried to explain how to prevent the negative effects of the COVID-19 pandemic on the diagnosis and treatment of breast cancer patients. In this process, as in many other types of cancer, there are also challenges in the management of breast cancer treatment due to the limited use of resources and the working discipline of the healthcare staff according to the pandemic conditions. High-priority: Recommendations are applied to patients whose condition is either clinically unstable or who have life-threatening cancer burden and requires immediate hospital treatment. [7] Diagnostic imaging for an abnormal mammogram or for suspicious symptoms of breast cancer, biopsies for BI-RADS 4 or 5 lesions, and breast MRI for the extent of disease evaluation or pre-chemotherapy assessment are still being performed in hospitals having sufficient resources because pandemic may be long-lasting and this may threaten patients'' lives in the long run. ER+ early breast cancer patients should have neoadjuvant endocrine therapy before surgery during the COVID-19 pandemic. abstract: The novel coronavirus disease (COVID-19) arises from the virus SARS-CoV-2 which is similar to the original SARS virus. The most common symptoms of the COVID-19 infection are fever, coughing and shortness of breath. According to the current data, the primary mode of transmission for the COVID-19 virus is between people through respiratory droplets and contact routes. The virus may lead to worse respiratory complications, including pneumonia, especially in older patients and patients with pre-existing illnesses, such as cancer. Cancer patients are at a significantly higher risk of getting infected with COVID-19 since their immune system can be compromised and that reality has to do with both that they have cancer and that they are on therapy for their cancer. COVID-19 crisis has impacted every aspect of the practice, including outpatient, elective, wards, emergency care, conferences, teaching and research. We should make sure cancer patients on active treatment are treated appropriately. In this review, we tried to explain how to prevent the negative effects of the COVID-19 pandemic on the diagnosis and treatment of breast cancer patients. url: https://doi.org/10.14744/semb.2020.23326 doi: 10.14744/semb.2020.23326 id: cord-297093-ld89vmct author: Clark, Kristina E N title: Safety of intravenous Anakinra in COVID-19 with evidence of hyperinflammation, a case series date: 2020-08-04 words: 3236.0 sentences: 198.0 pages: flesch: 46.0 cache: ./cache/cord-297093-ld89vmct.txt txt: ./txt/cord-297093-ld89vmct.txt summary: CONCLUSION: Intravenous anakinra is safe to use in patients with COVID-19 and evidence of supra-added bacterial infection. These patients all showed evidence of hyperinflammation with raised inflammatory markers, and CRP, and were given intravenous anakinra, with safe and successful use, suggesting the potential benefit from IL-1 blockade in this subgroup of patients with confirmed COVID-19. We present four cases of immunosuppressed patients, receiving beneficial effects from the use of intravenous anakinra to treat severe COVID-19 with hyperinflammation and concomitant bacterial infections. Our case series supports the hypothesis of IL-1 blockade as an important disease modifying treatment in those patients with severe late stage COVID-19, with evidence of cytokine storm. We believe that administering intravenous anakinra at the height of the cytokine storm has profound beneficial effects, both clinically and biochemically on patients with severe COVID-19 infection. abstract: OBJECTIVES: Anakinra is a selective IL-1 inhibitor, which has been used in the context of secondary haemophagocytic lymphohistiocytosis. Although usually given in the subcutaneous form, previous anecdotal reports have emphasized its utility when given intravenously. Our aim is to report our experience on the beneficial effects of intravenous anakinra in patients with SARS-CoV-2 and evidence of hyperinflammation. METHODS: We report 4 patients with severe COVID-19 infection requiring intensive care admission and ventilatory support. RESULTS: All four patients showed evidence of deterioration with hyperferritinaemia, and increasing oxygen requirements, with supra-added bacterial infections. Upon commencement of intravenous anakinra, there was subsequent improvement in the patients clinically with reducing ventilatory support and inotropic support, and biochemically, with rapid improvement in inflammatory markers. CONCLUSION: Intravenous anakinra is safe to use in patients with COVID-19 and evidence of supra-added bacterial infection. Although its utility has not been confirmed in a randomized trial, current research in the COVID-19 pandemic aims to establish the utility of immunosuppression, including IL-1 blockade on the outcomes of patients with moderate to severe disease. Our case series support its use in patients with severe-life threatening COVID-19 and evidence of hyperinflammation. url: https://doi.org/10.1093/rap/rkaa040 doi: 10.1093/rap/rkaa040 id: cord-010398-5wot7tix author: Clauw, Daniel J. title: Perspectives on Fatigue from the Study of Chronic Fatigue Syndrome and Related Conditions date: 2010-05-31 words: 10753.0 sentences: 454.0 pages: flesch: 40.0 cache: ./cache/cord-010398-5wot7tix.txt txt: ./txt/cord-010398-5wot7tix.txt summary: Also, these terms are consistent with the views held by practitioners who treat these patients and researchers who study them that CFS/ICF is a very heterogeneous disorder that, like many other chronic medical illnesses (eg, hypertension, diabetes), has a multiplicity of etiologic and pathogenic factors that contribute to the expression of the syndrome [12, 13] . There is now unanimity that at least a large subset of patients with CFS have a condition that is much broader than just CFS and has been labeled variously, including "functional somatic syndromes," "medically unexplained symptoms," "chronic multisymptom illnesses," "somatoform disorders," and perhaps most appropriately, "central sensitivity syndromes." Yunus [32] first showed FM to be associated with tension-type headache, migraine, and IBS; this author designed a Venn diagram in 1984 that emphasized the epidemiological and clinical overlaps between these syndromes and primary dysmenorrhea. abstract: Fatigue is a symptom whose causes are protean and whose phenotype includes physical, mood, and behavioral components. Chronic fatigue syndrome (CFS) is an illness that has strong biological underpinnings and no definite etiology. Diagnostic criteria established by the Centers for Disease Control and Prevention have helped classify CFS as an overlap of mood, behavioral, and biological components. These include the presence of fatigue for more than 6 months associated with a diminution of functional activity and somatic symptoms, and pain not attributable to a specific diagnosis or disease. Four of the following criteria need to be present: sore throat, impaired memory or cognition, unrefreshing sleep, postexertional fatigue, tender glands, aching stiff muscles, joint pain, and headaches. Many researchers have observed that CFS shares features in common with other somatic syndromes, including irritable bowel syndrome, fibromyalgia, and temporomandibular joint dysfunction. Correlations between inflammation and infection, augmented sensory processing, abnormalities of neurotransmitters, nerve growth factors, low levels of serotonin and norepinephrine, abnormalities of homeostasis of the stress system, and autonomic dysfunction may be hallmarks of CFS. The relative contributions of each of these abnormalities to the profound fatigue associated with CFS need to be explored further to better evaluate and treat the syndrome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185768/ doi: 10.1016/j.pmrj.2010.04.010 id: cord-031544-clzt6kyg author: Clavijo, Raul title: “Online” and “at-home” versus traditional models of health care: enhancing access or impeding optimal therapeutics? date: 2020-09-08 words: 4303.0 sentences: 209.0 pages: flesch: 38.0 cache: ./cache/cord-031544-clzt6kyg.txt txt: ./txt/cord-031544-clzt6kyg.txt summary: Thus, owing to the lack of physical exposure to clinical settings, it is likely that our patients with sexual dysfunction, with or without infertility, who stand to benefit the most from our taking a potential risk of prescribing medications after virtual care. Overall, the availability of prescription medications with well-defined risk profiles to patients through virtual sources is only likely to enhance the access to care for sexual and reproductive health conditions by easing the pain of embarrassment some patients may experience. In light of the current situation of the COVID pandemic along with the boom of telemedicine, physicians should consider incorporating home-based kits for both male and female fertility testing with the caveats that even though we may not get accurate data all the time, data from these kits can be used to guide care. Although physical examination and in-office diagnostics are paramount for the evaluation of both female and male fertility, an initial telehealth visit can uncover pertinent history, identify risk factors, and establish the physician-patient relationship. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476901/ doi: 10.1016/j.fertnstert.2020.07.017 id: cord-305205-ilxxkm0f author: Cochennec, Frédéric title: Impact of intraoperative adverse events during branched and fenestrated aortic stent grafting on postoperative outcome date: 2014-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective Fenestrated and branched endovascular devices are increasingly used for complex aortic diseases, and despite the challenging nature of these procedures, early experiences from pioneering centers have been encouraging. The objectives of this retrospective study were to report our experience of intraoperative adverse events (IOAEs) during fenestrated and branched stent grafting and to analyze the impact on clinical outcomes. Methods Consecutive patients treated with fenestrated and branched stent grafting in a tertiary vascular center between February 2006 and October 2013 were evaluated. A prospectively maintained computerized database was scrutinized and updated retrospectively. Intraoperative angiograms were reviewed to identify IOAEs, and adverse events were categorized into three types: target vessel cannulation, positioning of graft components, and intraoperative access. Clinical consequences of IOAEs were analyzed to ascertain whether they were responsible for death or moderate to severe postoperative complications. Results During the study period, 113 consecutive elective patients underwent fenestrated or branched stent grafting. Indications for treatment were asymptomatic complex abdominal aortic aneurysms (CAAAs, n = 89) and thoracoabdominal aortic aneurysms (TAAAs, n = 24). Stent grafts included fenestrated (n = 79) and branched (n = 17) Cook stent grafts (Cook Medical, Bloomington, Ind), Ventana (Endologix, Irvine, Calif) stent grafts (n = 9), and fenestrated Anaconda (Vascutek Terumo, Scotland, UK) stent grafts (n = 8). In-hospital mortality rates for the CAAA and TAAA groups were 6.7% (6 of 89) and 12.5% (3 of 24), respectively. Twenty-eight moderate to severe complications occurred in 21 patients (18.6%). Spinal cord ischemia was recorded in six patients, three of which resolved completely. A total of 37 IOAEs were recorded in 34 (30.1%) patients (22 CAAAs and 12 TAAAs). Of 37 IOAEs, 15 (40.5%) resulted in no clinical consequence in 15 patients; 17 (45.9%) were responsible for moderate to severe complications in 16 patients, and five (13.5%) led to death in four patients. The composite end point death/nonfatal moderate to severe complication occurred more frequently in patients with IOAEs compared with patients without IOAEs (20 of 34 vs 12 of 79; P < .0001). Conclusions In this contemporary series, IOAEs were relatively frequent during branched or fenestrated stenting procedures and were often responsible for significant complications. url: https://www.sciencedirect.com/science/article/pii/S0741521414006545 doi: 10.1016/j.jvs.2014.02.065 id: cord-016308-qzkcwrit author: Cochran, Christina L. title: Neonatal Emergencies date: 2015-11-06 words: 2764.0 sentences: 323.0 pages: flesch: 44.0 cache: ./cache/cord-016308-qzkcwrit.txt txt: ./txt/cord-016308-qzkcwrit.txt summary: • Initial signs of respiratory distress include tachypnoea and increased work of breathing (Table 11 .1 ) • As distress progresses, newborns are at risk of developing respiratory failure and apnoea. • RDS presents in the fi rst days of life (Table 11 .2 ) • Bronchiolitis is a clinical diagnosis based on physical exam and history [ 3 ] . • Consider hypoglycaemia, metabolic dysfunction, hyperbilirubinemia, congenital heart conditions, and neurologic dysfunction when assessing a patient with the above features. • Most cases of hyperbilirubinemia are physiologic, or secondary to normal delayed conjugation and excretion of bilirubin in the newborn, though pathologic aetiologies must be considered. • Management of Hirschsprung''s Disease is reviewed in Table 11 .11 • In the case of toxic megacolon, provide resuscitation as clinically indicated and IV antibiotics • Consider thyroid studies in patients with clinical signs or maternal history of antithyroid antibodies. abstract: Newborns may present with vague signs and symptoms that result from a large variety of aetiologies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120553/ doi: 10.1007/978-81-322-2713-7_11 id: cord-338362-6zwvkqag author: Cohen, Donald F. title: Ethical practice during the COVID-19 pandemic date: 2020-04-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32276721/ doi: 10.1016/j.adaj.2020.03.038 id: cord-025176-f0frlpwh author: Coimbra, Raul title: Resuming elective surgical services in times of COVID-19 infection date: 2020-05-19 words: 2884.0 sentences: 142.0 pages: flesch: 41.0 cache: ./cache/cord-025176-f0frlpwh.txt txt: ./txt/cord-025176-f0frlpwh.txt summary: 15 Most recommendations from public health officials have suggested that a steady decrease in the number of new COVID-19 cases over a period of 14 days (decreased incidence), associated with a similar trend in hospital and ICU admission, is necessary to consider resuming elective surgery (box 1). However, it is important that a staged system be implemented with partial reopening followed by interval full reassessment of the system, as the incidence of COVID-19 infection may have decreased further, allowing the opening of more operating rooms, increasing the overall number of procedures performed. After a functional period in stage 1, a reassessment of the COVID-19 infection in the community and in the hospital should occur to determine if adding operating room capacity and increasing the number of surgical cases is warranted. abstract: The consequences of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus have been devastating to the healthcare system. As the positive effects of social distancing, mandatory masking, and societal lockdown on the spread of the disease and its incidence in the community were documented, societal and financial pressures mounted worldwide, prompting efforts to “re-open” countries, states, communities, businesses, and schools. The same happened with hospital, which had to start developing strategies to resume elective surgery activities. This manuscript describes the pre-requisites as well as the strategies for resuming surgical activity, be it in the outpatient or inpatient setting. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246095/ doi: 10.1136/tsaco-2020-000511 id: cord-260854-v7wgb6mr author: Colafrancesco, Serena title: COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome? date: 2020-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term “hyperferritinemic syndrome” and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and “hyperferritinemic syndromes” are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and “hyperferritinemic syndromes” which would allow considering this entity as the fifth member of the spectrum of inflammatory conditions. url: https://api.elsevier.com/content/article/pii/S156899722030135X doi: 10.1016/j.autrev.2020.102573 id: cord-013139-b32xg7y7 author: Colak, Fatma Kurt title: An intronic variant in BRAT1 creates a cryptic splice site, causing epileptic encephalopathy without prominent rigidity date: 2020-10-10 words: 2783.0 sentences: 147.0 pages: flesch: 44.0 cache: ./cache/cord-013139-b32xg7y7.txt txt: ./txt/cord-013139-b32xg7y7.txt summary: Since the discovery of BRAT1 variants as the molecular etiology of lethal neonatal rigidity and multifocal seizure syndrome (RMFSL, OMIM 614498), these variants have also been identified in patients with milder clinical forms including neurodevelopmental disorder with cerebellar atrophy and with or without seizures (NEDCAS, OMIM 618056), epilepsy of infancy with migrating focal seizures (EIMFS), and congenital ataxia (CA). This study aims to examine the consequences and pathogenicity of a novel homozygous splice site variant in BRAT1 in a patient presenting with migrating focal seizures since birth without prominent rigidity. RMFSL was first described in 2012; later, BRAT1 variants were also reported in patients with non-lethal milder clinical forms, including neurodevelopmental disorder with cerebellar atrophy and with or without seizures (NEDCAS, 618056), epilepsy of infancy with migrating focal seizures (EIMFS), and congenital ataxia (CA) [7] [8] [9] [10] . abstract: BRAT1-related neurodevelopmental disorders are characterized by heterogeneous phenotypes with varying levels of clinical severity. Since the discovery of BRAT1 variants as the molecular etiology of lethal neonatal rigidity and multifocal seizure syndrome (RMFSL, OMIM 614498), these variants have also been identified in patients with milder clinical forms including neurodevelopmental disorder with cerebellar atrophy and with or without seizures (NEDCAS, OMIM 618056), epilepsy of infancy with migrating focal seizures (EIMFS), and congenital ataxia (CA). This study aims to examine the consequences and pathogenicity of a novel homozygous splice site variant in BRAT1 in a patient presenting with migrating focal seizures since birth without prominent rigidity. The patient was born from a consanguineous marriage and has had seizures since the neonatal period. He presented with dysmorphic features, pontocerebellar hypoplasia, and migrating focal seizures. Despite supportive treatment, his symptoms rapidly progressed to intractable myoclonic seizures, bouts of apnea and bradycardia, and arrest of head growth, with no acquisition of developmental milestones. Clinical exome sequencing yielded a novel homozygous splice variant in BRAT1. Genetic analysis based on reverse transcription of the patient’s RNA followed by PCR amplifications performed on synthesized cDNA and Sanger sequencing was undertaken, and the functional effect of a BRAT1 variant on splicing machinery was demonstrated for the first time. The severe clinical presentation of migrating focal seizures and pontocerebellar hypoplasia in the absence of rigidity further expands the genotypic and phenotypic spectrum of BRAT1-related neurodevelopmental disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13760-020-01513-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547818/ doi: 10.1007/s13760-020-01513-0 id: cord-323831-1qadv7r1 author: Coleman, H title: Severe acute respiratory syndrome coronavirus-2 in post-laryngectomy patients: case series of four patients date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To report our experience of diagnosis, investigation and management in patients who had undergone laryngectomy secondary to previous squamous cell carcinoma, who were subsequently infected with severe acute respiratory syndrome coronavirus-2 during the coronavirus disease 2019 pandemic. CASE REPORTS: Four post-laryngectomy patients with laboratory-proven severe acute respiratory syndrome coronavirus-2 infection were admitted to our institution from 1 March to 1 May 2020. All patients displayed symptoms of coronavirus disease 2019 and underwent investigations, including swab and serum sampling, and chest X-ray where indicated. All were managed conservatively on dedicated coronavirus disease 2019 wards and were discharged without the requirement of higher level care. CONCLUSION: It is hypothesised that laryngectomy may offer a protective effect against severe or critical disease in severe acute respiratory syndrome coronavirus-2 infection. We hope sharing our experience will aid all practitioners in the management of this, often intimidating, cohort of patients. url: https://doi.org/10.1017/s0022215120001310 doi: 10.1017/s0022215120001310 id: cord-030927-wo8r8zny author: Collins, Curtis D title: Perspectives from the frontline: A pharmacy department’s response to the COVID-19 pandemic date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: The global coronavirus 2019 (COVID-19) pandemic has created unprecedented strains on healthcare systems around the world. Challenges surrounding an overwhelming influx of patients with COVID-19 and changes in care dynamics prompt the need for care models and processes that optimize care in this medically complex patient population. The purpose of this report is to describe our institution’s strategy to deploy pharmacy resources and standardize pharmacy processes to optimize the management of patients with COVID-19. METHODS: This retrospective, descriptive report characterizes documented pharmacy interventions in the acute care of patients admitted for COVID-19 during the period April 1 to April 15, 2020. Patient monitoring, interprofessional communication, and intervention documentation by pharmacy staff was facilitated through the development of a COVID-19–specific care bundle integrated into the electronic medical record. RESULTS: A total of 1,572 pharmacist interventions were documented in 197 patients who received a total of 15,818 medication days of therapy during the study period. The average number of interventions per patient was 8. The most common interventions were regimen simplification (15.9%), timing and dosing adjustments (15.4%), and antimicrobial therapy and COVID-19 treatment adjustments (15.2%). Patients who were admitted to an intensive care unit care at any point during their hospital stay accounted for 66.7% of all interventions documented. CONCLUSION: A pharmacy department’s response to the COVID-19 pandemic was optimized through standardized processes. Pharmacists intervened to address a wide scope of medication-related issues, likely contributing to improved management of COVID-19 patients. Results of our analysis demonstrate the vital role pharmacists play as members of multidisciplinary teams during times of crisis. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449257/ doi: 10.1093/ajhp/zxaa176 id: cord-302788-kg8zwysg author: Conrad, Rachel C. title: Duties toward Patients with Psychiatric Illness date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patients with psychiatric illness feel the brunt of the intersection of many of our society's and our health care system's disparities, and the vulnerability of this population during the Covid‐19 pandemic cannot be overstated. Patients with psychiatric illness often suffer from the stigma of mental illness and receive poor medical care. Many patients with severe and persistent mental illness face additional barriers, including poverty, marginal housing, and food insecurity. Patients who require psychiatric hospitalization now face the risk of transmission of Covid‐19 due to the inherent difficulties of social distancing within a psychiatric hospital. Patients whose freedom and self‐determination have been temporarily overruled as they receive involuntary psychiatric treatment deserve a setting that maintains their health and safety. While tele‐mental health has been rapidly expanded to provide new ways to access psychiatric treatment, some patients may have limitations in technological literacy or access to devices. The social isolation, economic fallout, and potential traumatization related to the current pandemic will disproportionately affect this vulnerable population, and society's duties to them must be considered. url: https://www.ncbi.nlm.nih.gov/pubmed/32596900/ doi: 10.1002/hast.1139 id: cord-339517-93nuovsj author: Consolo, Ugo title: Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The outbreak and diffusion of the Severe Acute Respiratory Syndrome-Coronavirus-2 (Sars-CoV-2) and COronaVIrus Disease 19 (COVID-19) have caused an emergency status in the health system, including in the dentistry environment. Italy registered the third highest number of COVID-19 cases in the world and the second highest in Europe. An anonymous online survey composed of 40 questions has been sent to dentists practicing in the area of Modena and Reggio Emilia, one of the areas in Italy most affected by COVID-19. The survey was aimed at highlighting the practical and emotional consequences of COVID-19 emergence on daily clinical practice. Specifically, it assessed dentists’ behavioral responses, emotions and concerns following the Sars-CoV-2 pandemic restrictive measures introduced by the Italian national administrative order of 10 March 2020 (DM-10M20), as well as the dentists’ perception of infection likelihood for themselves and patients. Furthermore, the psychological impact of COVID-19 was assessed by means of the Generalized Anxiety Disorder-7 test (GAD-7), that measures the presence and severity of anxiety symptoms. Using local dental associations (ANDI-Associazione Nazionale Dentisti Italiani, CAO-Commissione Albo Odontoiatri) lists, the survey was sent by email to all dentists in the district of Modena and Reggio Emilia (874 practitioners) and was completed by 356 of them (40%). All dental practitioners closed or reduced their activity to urgent procedures, 38.2% prior to and 61.8% after the DM-10M20. All reported a routinely use of the most common protective personal equipment (PPE), but also admitted that the use of PPE had to be modified during COVID-19 pandemic. A high percentage of patients canceled their previous appointments after the DM-10M20. Almost 85% of the dentists reported being worried of contracting the infection during clinical activity. The results of the GAD-7 (General Anxiety Disorder-7) evaluation showed that 9% of respondents reported a severe anxiety. To conclude, the COVID-19 emergency is having a highly negative impact on the activity of dentists practicing in the area of Modena and Reggio Emilia. All respondents reported practice closure or strong activity reduction. The perception of this negative impact was accompanied by feelings of concern (70.2%), anxiety (46.4%) and fear (42.4%). The majority of them (89.6%) reported concerns about their professional future and the hope for economic measures to help dental practitioners. url: https://www.ncbi.nlm.nih.gov/pubmed/32429193/ doi: 10.3390/ijerph17103459 id: cord-351555-hsgsuor2 author: Constantinou, Constantina title: Developing a holistic contingency plan: Challenges and dilemmas for cancer patients during the COVID‐19 date: 2020-07-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: During the first quarter of 2020 the world is experiencing a pandemic of Severe Acute Respiratory Syndrome‑Coronavirus‑2 (SARS‑CoV‑2), a novel beta coronavirus that is responsible for the 2019 novel coronavirus disease (COVID‐19). The COVID‐19 pandemic revealed that healthcare systems around the world were not prepared to deal with either the direct effects of the pandemic or with the indirect effects that are imposed on the health of patients with chronic disorders such as cancer patients. Some challenges and dilemmas currently faced during the pandemic include the management of cancer patients during the treatment and follow‐up phases, the assessment of the safety of treatments currently used for the management of SARS‑CoV‑2 for use in cancer patients, the development of psychoeducation and emotional support for cancer patients and the safe conduct of clinical trials involving participation of cancer patients. Evidence from the literature supports the need for the urgent development of a holistic contingency plan which will include clear guidelines for the protection and comprehensive care of cancer patients. The implementation of such a plan is expected to have many beneficial effects by mainly minimizing the increased morbidity and mortality of cancer patients that could result as an adverse consequence of the COVID‐19 or future pandemics. url: https://doi.org/10.1002/cam4.3271 doi: 10.1002/cam4.3271 id: cord-341999-nosdj7b2 author: Conti, A. title: Evolution of COVID‐19 infection in 4 psoriatic patients treated with biological drugs date: 2020-05-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Since December 2019, the pandemic coronavirus disease (2019‐nCoV; COVID‐19) has changed the approach to all dermatological diseases; in particular, psoriatic patients undergoing immunosuppressive drugs, such as biologics, can potentially show an increase risk of infection (1). However, few reports are available on the course of COVID‐19 infection in psoriatic patients treated with biological drugs (2). We describe a case series of four psoriatic patients treated with biologics who had a risk contact with COVID‐19. url: https://doi.org/10.1111/jdv.16587 doi: 10.1111/jdv.16587 id: cord-349565-g1emvmdu author: Conti, Clara Benedetta title: Bleeding in COVID-19 severe pneumonia: The other side of abnormal coagulation pattern? date: 2020-05-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S0953620520301874 doi: 10.1016/j.ejim.2020.05.002 id: cord-282730-pawasfh4 author: Contreras, Carlo M. title: Telemedicine: Patient-Provider Clinical Engagement During the COVID-19 Pandemic and Beyond date: 2020-05-08 words: 3568.0 sentences: 216.0 pages: flesch: 45.0 cache: ./cache/cord-282730-pawasfh4.txt txt: ./txt/cord-282730-pawasfh4.txt summary: RESULTS: At many institutions, the number of telemedicine visits dramatically increased within days following the institution of novel coronavirus pandemic restrictions on in-person clinical encounters. To minimize interruption of crucial clinical services and the associated revenue, a rapid transition from in-person outpatient visits to telemedicine encounters was implemented by many academic medical centers and adopted by surgery departments throughout the country. The Centers for Medicare and Medicaid Services (CMS) sought to decrease in-person medical visits by issuing a temporary and emergency relaxation of telemedicine rules via the 1135 waiver and the Coronavirus Preparedness and Response Supplemental Appropriations Act. Enacted on March 6, 2020, this act allowed Original Medicare enrollees the same telemedicine benefits that had been extended to Medicare Advantage enrollees in January 2020. In addition, on March 13, 2020 the FCC funded the Rural Health Care Program that aims to make telemedicine services available to geographically remote patients. abstract: BACKGROUND: The novel coronavirus pandemic has drastically affected healthcare organizations across the globe. METHODS: We sought to summarize the current telemedicine environment in order to highlight the important changes triggered by the novel coronavirus pandemic, as well as highlight how the current crisis may inform the future of telemedicine. RESULTS: At many institutions, the number of telemedicine visits dramatically increased within days following the institution of novel coronavirus pandemic restrictions on in-person clinical encounters. Prior to the pandemic, telemedicine utilization was weak throughout surgical specialties due to regulatory and reimbursement barriers. As part of the pandemic response, the USA government temporarily relaxed various telemedicine restrictions and provided additional telemedicine funding. DISCUSSION: The post-pandemic role of telemedicine is dependent on permanent regulatory solutions. In the coming decade, telemedicine and telesurgery are anticipated to mature due to the proliferation of interconnected consumer health devices and high-speed 5G data connectivity. url: https://www.ncbi.nlm.nih.gov/pubmed/32385614/ doi: 10.1007/s11605-020-04623-5 id: cord-305405-me4gebvm author: Conway, J. title: Characteristics of patients with diabetes hospitalised for COVID-19 infection-a brief case series report date: 2020-09-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objectives Diabetes has been shown to be a risk factor for corona virus disease-2019 (COVID-19) infection. The characteristics of patients with diabetes vulnerable to this infection are less specified. We aim to present the characteristics of patients with diabetes admitted to hospital with COVID-19. Design: A retrospective case series. Setting: A single clinical centre in the UK. Methods We have retrospectively collected the demographics, medical characteristics and outcome of all patients with diabetes admitted to hospital over two-week period with COVID-19 infection. All cases were diagnosed by a reverse transcription polymerase chain reaction (RT-PCR) of pharyngeal and nasal swabs. Results A total of 71 COVID-19 patients were admitted during the study period of whom 16 (22.5%) patients had diabetes and were included in this case series. There was no significant difference between patients with compared to those without diabetes regarding age, gender or clinical presentation. However, comorbidities were more common in patients with diabetes specially hypertension {75% v 36.4%, a difference of 38.6%, 95% confidence interval (CI) 6.5 to 58.3} and chronic kidney disease (37.5 v 5.5, a difference of 32% (1.6 to 51.6). Patients with diabetes were significantly more obese than those without diabetes (56.2% v 21.8% a difference of 34.4%, 95% CI 7.7 to 61.1). About one third (31.3%) of patients with diabetes were frail. Mean {standard deviation (SD)} duration of diabetes was 10 (2.8) years and mean (SD) HbA1c was 60.3 (15.6) mmol/mol. The use of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and non-steroidal anti-inflammatory drugs (NSAIDs) was common (37.5%, 25% and 18.8% respectively). There was no significant difference in the outcomes between patients with compared to those without diabetes. Conclusion Patients with diabetes hospitalised for COVID-19 were significantly more obese and had high prevalence of comorbidities than those without diabetes. Other features of patients with diabetes and COVID-19 infection included long duration of diabetes, less tight glycaemic control and common use of ACE inhibitors, ARBs and NSAIDs. url: https://www.ncbi.nlm.nih.gov/pubmed/32971153/ doi: 10.1016/j.diabres.2020.108460 id: cord-282535-gnuhjs32 author: Cook, Gordon title: Real‐world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID‐19 disease) in patients with Multiple Myeloma receiving systemic anti‐cancer therapy. date: 2020-05-21 words: 1301.0 sentences: 68.0 pages: flesch: 50.0 cache: ./cache/cord-282535-gnuhjs32.txt txt: ./txt/cord-282535-gnuhjs32.txt summary: title: Real‐world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID‐19 disease) in patients with Multiple Myeloma receiving systemic anti‐cancer therapy. . The UK index case was identified on the 31 st of January, 2020 and given the rapid spread and high mortality rate of COVID-19, it is imperative to define the impact on patients with co-existing medical conditions (3) . Multiple Myeloma (MM), the second most common haematological malignancy, is a cancer of the mature B-cell lineage and is associated with both cellular and humoral immune dysfunction that renders patients susceptible to infections, especially of the respiratory tract (4) (5) (6) (7) . This coupled with a median age at presentation of 70 years in a population with frequent co-existing medical conditions, means the outcomes of MM patients infected with COVID-19 warrants particular attention. abstract: Infection with the novel coronavirus SARS‐CoV‐2 virus resulting in an acute respiratory disease (COVID‐19 disease) is the cause of the current pneumonia pandemic, with a rapid rise in cases being reported in the European Union and UK (1, 2). The UK index case was identified on the 31(st) of January, 2020 and given the rapid spread and high mortality rate of COVID‐19, it is imperative to define the impact on patients with co‐existing medical conditions(3). url: https://www.ncbi.nlm.nih.gov/pubmed/32438482/ doi: 10.1111/bjh.16874 id: cord-354194-hf5ndv5f author: Cook, Mackenzie title: Prioritizing Communication in the Provision of Palliative Care for the Trauma Patient date: 2020-10-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: Communication skills in the ICU are an essential part of the care of trauma patients. The goal of this review is to summarize key aspects of our understanding of communication with injured patients in the ICU. RECENT FINDINGS: The need to communicate effectively and empathetically with patients and identify primary goals of care is an essential part of trauma care in the ICU. The optimal design to support complex communication in the ICU will be dependent on institutional experience and resources. The best/worst/most likely model provides a structural model for communication. SUMMARY: We have an imperative to improve the communication for all patients, not just those at the end of their life. A structured approach is important as is involving family at all stages of care. Communication skills can and should be taught to trainees. url: https://doi.org/10.1007/s40719-020-00201-x doi: 10.1007/s40719-020-00201-x id: cord-309482-frawgvk7 author: Cook, T. M. title: Kicking on while it’s still kicking off – getting surgery and anaesthesia restarted after COVID‐19 date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The UK National Health Service (NHS) has risen to the challenge posed by COVID-19 through Herculean efforts to expand capacity. This has included doubling or trebling intensive care (ICU) capacity within hospitals, augmenting this with Nightingale Hospitals, cancelling all non-emergency surgery and redeploying staff and equipment to focus on a single disease. At the same time, government and population efforts have - through social distancing then lockdown- successfully flattened the epidemic curve and so reduced demand. Together, these actions have enabled treatment of all those needing hospital care for COVID-19 and avoided the unfettered increase in mortality that would have accompanied an overwhelmed healthcare service. url: https://www.ncbi.nlm.nih.gov/pubmed/32428245/ doi: 10.1111/anae.15128 id: cord-029626-j6b59y7a author: Cooley, Laura title: Fostering Human Connection in the Covid-19 Virtual Health Care Realm date: 2020-05-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As telehealth becomes more mainstream, finding ways to add compassion and understanding to your communications with patients and colleagues is increasingly important. Here are some evidence-based, relationship-centered tips for enhancing these virtual encounters. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371327/ doi: 10.1056/cat.20.0166 id: cord-265818-wme1360n author: Cooley, Laura title: Trust and Communication: Responding to Uncertainty date: 2020-07-15 words: 562.0 sentences: 40.0 pages: flesch: 48.0 cache: ./cache/cord-265818-wme1360n.txt txt: ./txt/cord-265818-wme1360n.txt summary: Patients and families often struggle with the uncertainties related to personal health and the delivery of care. Heightened emotional states threaten the quality of communication encounters for both patients/families and clinicians/staff. Encouragingly, despite the recent difficulties threatening relationships in health care, clinicians and staff have resiliently responded to the challenge. A recent article published Harvard Business Review highlighted upward trends in patient experience scores during the spring months of the 2020 COVID-19 pandemic: "For example, ratings of the skill of physicians rose 2.4% nationally, 2.8% in Washington and 10.4% in New York. (2) In this issue of The Journal of Patient Experience, I am pleased to feature several "Special Collection" submissions reflecting the context of COVID-19 and/or Telehealth. While our collective energy may continue to be influenced by the pandemic, this issue also contains an assortment of patient experience research and perspective articles. Implications of the current COVID-19 pandemic for communication in healthcare abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32821778/ doi: 10.1177/2374373520938476 id: cord-252243-ua2w6xki author: Cooper, Emily title: Diagnosis and Management of UTI in Primary Care Settings—A Qualitative Study to Inform a Diagnostic Quick Reference Tool for Women Under 65 Years date: 2020-09-07 words: 8711.0 sentences: 509.0 pages: flesch: 57.0 cache: ./cache/cord-252243-ua2w6xki.txt txt: ./txt/cord-252243-ua2w6xki.txt summary: Results: Staff were very aware of common UTI symptoms and nitrofurantoin as first-line treatment, but some were less aware about when to send a urine culture, second-line and non-antibiotic management, and did not probe for signs and symptoms to specifically exclude vaginal causes or pyelonephritis before prescribing. • Clearly outlines how to clinically assess someone with suspected UTI; • Includes prompts/considerations around differential diagnosis, pyelonephritis, and sepsis; • Clearly outlines the steps for clinical assessment of someone with suspected UTI and when a urine dipstick test or culture is needed; • Provides information on the sensitivity and specificity when using urine dipsticks to diagnose a UTI for women under 65 years; • Has been developed as an update to previous guidance; • Links to latest national guidance on antimicrobial prescribing for UTI management (developed since this study was conducted); • Links to UTI leaflets and resources for women under 65 years that explains evidenced-based prevention and self-care recommendations. abstract: Background: To inform interventions to improve antimicrobial use in urinary tract infections (UTIs) and contribute to a reduction in Escherichia coli bloodstream infection, we explored factors influencing the diagnosis and management of UTIs in primary care. Design: Semi-structured focus groups informed by the Theoretical Domains Framework. Setting: General practice (GP) surgeries in two English clinical commissioning groups (CCGs), June 2017 to March 2018. Participants: A total of 57 GP staff within 8 focus groups. Results: Staff were very aware of common UTI symptoms and nitrofurantoin as first-line treatment, but some were less aware about when to send a urine culture, second-line and non-antibiotic management, and did not probe for signs and symptoms to specifically exclude vaginal causes or pyelonephritis before prescribing. Many consultations were undertaken over the phone, many by nurse practitioners, and followed established protocols that often included urine dipsticks and receptionists. Patient expectations increased use of urine dipsticks, and immediate and 5 days courses of antibiotics. Management decisions were also influenced by patient co-morbidities. No participants had undertaken recent UTI audits. Patient discussions around antibiotic resistance and back-up antibiotics were uncommon compared to consultations for respiratory infections. Conclusions: Knowledge and skill gaps could be addressed with education and clear, accessible, UTI diagnostic and management guidance and protocols that are also appropriate for phone consultations. Public antibiotic campaigns and patient-facing information should cover UTIs, non-pharmaceutical recommendations for “self-care”, prevention and rationale for 3 days antibiotic courses. Practices should be encouraged to audit UTI management. url: https://doi.org/10.3390/antibiotics9090581 doi: 10.3390/antibiotics9090581 id: cord-315574-jq1p5t8w author: Copland, Michael title: Canadian Society of Nephrology COVID-19 Rapid Response Team Home Dialysis Recommendations date: 2020-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF PROGRAM: This paper will provide guidance on how to best manage patients with end-stage kidney disease who will be or are being treated with home dialysis during the COVID-19 pandemic. SOURCES OF INFORMATION: Program-specific documents, pre-existing, and related to COVID-19; documents from national and international kidney agencies; national and international webinars, including webinars that we hosted for input and feedback; with additional information from formal and informal review of published academic literature. METHODS: Members of the Canadian Society of Nephrology (CSN) Board of Directors solicited a team of clinicians and administrators with expertise in home dialysis. Specific COVID-19-related themes in home dialysis were determined by the Canadian senior renal leaders community of practice, a group compromising medical and administrative leaders of provincial and health authority renal programs. We then developed consensus-based recommendations virtually by the CSN work-group with input from ethicists with nephrology training. The recommendations were further reviewed by community nephrologists and over a CSN-sponsored webinar, attended by 225 kidney health care professionals, for further peer input. The final consensus recommendations also incorporated review by the editors at the Canadian Journal of Kidney Health and Disease (CJKHD). KEY FINDINGS: We identified 7 broad areas of home dialysis practice management that may be affected by the COVID-19 pandemic: (1) peritoneal dialysis catheter placement, (2) home dialysis training, (3) home dialysis management, (4) personal protective equipment, (5) product delivery, (6) minimizing direct health care provider and patient contact, and (7) assisted peritoneal dialysis in the community. We make specific suggestions and recommendations for each of these areas. LIMITATIONS: This suggestions and recommendations in this paper are expert opinion, and subject to the biases associated with this level of evidence. To expedite the publication of this work, a parallel review process was created that may not be as robust as standard arms’ length peer-review processes. IMPLICATIONS: These recommendations are intended to provide the best care possible during a time of altered priorities and reduced resources. url: https://doi.org/10.1177/2054358120928153 doi: 10.1177/2054358120928153 id: cord-023509-tvqpv6fp author: Corrin, Bryan title: Occupational, environmental and iatrogenic lung disease date: 2011-03-02 words: 42576.0 sentences: 2457.0 pages: flesch: 45.0 cache: ./cache/cord-023509-tvqpv6fp.txt txt: ./txt/cord-023509-tvqpv6fp.txt summary: As a general rule, exposure to silica dust extends over many years, often 20 or more, before the symptoms of silicosis first appear: by the time the disease becomes overt clinically, much irreparable damage has been inflicted on the lungs. Confusingly, the term ''acute silicosis'' has since been applied to a further effect of heavy dust exposure in tunnellers, sand blasters and silica flour workers, namely pulmonary alveolar lipoproteinosis (see below), 71, 72 whilst the terms ''accelerated silicosis'' or ''cellular phase silicosis'' have been substituted for ''acute silicosis'' in referring to the rapid development of early cellular lesions. Asbestosis is defined as diffuse interstitial fibrosis of the lung caused by exposure to asbestos dust. The finely divided fume of several metals is highly toxic to the lungs and capable of producing severe acute and chronic damage to both the conductive airways and the alveoli, resulting in acute tracheobronchitis and bronchiolitis, diffuse alveolar damage, obliterative bronchiolitis and pulmonary fibrosis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170212/ doi: 10.1016/b978-0-7020-3369-8.00007-0 id: cord-303819-w1785lap author: Cortegiani, Andrea title: Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19 date: 2020-07-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To assess efficacy and safety of chloroquine (CQ)/hydroxychloroquine (HCQ) for treatment or prophylaxis of COVID-19 in adult humans. MATERIALS AND METHODS: MEDLINE, PubMed, EMBASE and two pre-print repositories (bioRxiv, medRxiv) were searched from inception to 8th June 2020 for RCTs and nonrandomized studies (retrospective and prospective, including single-arm, studies) addressing the use of CQ/HCQ in any dose or combination for COVID-19. RESULTS: Thirty-two studies were included (6 RCTs, 26 nonrandomized, 29,192 participants). Two RCTs had high risk, two ‘some concerns’ and two low risk of bias (Rob2). Among nonrandomized studies with comparators, nine had high risk and five moderate risk of bias (ROBINS-I). Data synthesis was not possible. Low and moderate risk of bias studies suggest that treatment of hospitalized COVID-19 with CQ/HCQ may not reduce risk of death, compared to standard care. High dose regimens or combination with macrolides may be associated with harm. Postexposure prophylaxis may not reduce the rate of infection but the quality of the evidence is low. CONCLUSIONS: Patients with COVID-19 should be treated with CQ/HCQ only if monitored and within the context of high quality RCTs. High quality data about efficacy/safety are urgently needed. url: https://doi.org/10.1016/j.jcrc.2020.06.019 doi: 10.1016/j.jcrc.2020.06.019 id: cord-291469-cohrewj5 author: Cortese, Bernardo title: How is the cardiovascular patient managed during Covid‐19 pandemic? A report from the frontline date: 2020-05-20 words: 490.0 sentences: 30.0 pages: flesch: 61.0 cache: ./cache/cord-291469-cohrewj5.txt txt: ./txt/cord-291469-cohrewj5.txt summary: His father had died of sudden death after 3 days of remittent chest pain and dyspnea, but did not come to our emergency room for the Luckily, we expect that the vast majority of patients with cardiovascular disease in the Covid-era will survive, and will ultimately develop heart failure in the next few months. Since the beginning of the pandemic, we have heard of protocols, distance, masks, lock-down, but not a single word has been spent regarding how will we be able to manage the new cardiovascular pandemic in the next few months, when everything will be open again and patients will not refuse to come to our emergency rooms and office visits. However, since the median stay of a Covid-19 patient in Lombardy is 23 days if he had a transit through the ICU, and 14 days if not, 3-5 it is expected that in the next 2-3 months all hospitals in the region will have dedicated resources and wards for this disease. abstract: nan url: https://doi.org/10.1002/ccd.28966 doi: 10.1002/ccd.28966 id: cord-314694-g0pes5o3 author: Cortiula, F. title: Managing COVID-19 in the oncology clinic and avoiding the distraction effect date: 2020-03-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0923753420363730 doi: 10.1016/j.annonc.2020.03.286 id: cord-285354-bp2dozzg author: Costanzi, Andrea title: In response to: Surgery in the COVID-19 phase 2 Italian scenario: Lessons learned in Northern Italy spoke hospitals date: 2020-07-01 words: 1312.0 sentences: 77.0 pages: flesch: 55.0 cache: ./cache/cord-285354-bp2dozzg.txt txt: ./txt/cord-285354-bp2dozzg.txt summary: 1097 W e read with interest the article "COVID-19 outbreak in Northern Italy: Viewpoint of the Milan area surgical community," which reported the pandemic surge response of our colleagues within tertiary hospitals in Lombardy. As surgeons operating in spoke hospitals, we have paved through the pandemic in an unusual and unexpected way, many of us having to turn from surgical specialists into coronavirus disease (COVID) ward doctors. Nonetheless, being a surgeon used to emergencies in peripheral hospitals was a valuable resource during the COVID mass casualty incident because of our commitment to patients and acute care background. 1 Our daily schedule changed dramatically when we were asked to cancel elective surgery to increase the hospital capacity in mechanical respirators and intensive care personnel for COVID-19 patients. Surgery in the coronavirus disease 2019 phase 2 Italian scenario:Lessons learned in northern Italy spoke hospitals W e thank Dr. Costanzi and colleagues for their appreciation and interesting insights about our work. abstract: nan url: https://doi.org/10.1097/ta.0000000000002838 doi: 10.1097/ta.0000000000002838 id: cord-277889-8u685f45 author: Costela-Ruiz, Víctor J. title: SARS-CoV-2 infection: the role of cytokines in COVID-19 disease date: 2020-06-02 words: 9212.0 sentences: 552.0 pages: flesch: 49.0 cache: ./cache/cord-277889-8u685f45.txt txt: ./txt/cord-277889-8u685f45.txt summary: The majority of patients infected with COVID-19 have normal or reduced white cell counts and lymphocytopenia, and those with severe disease have shown significantly elevated levels of neutrophils, dimer-D, and urea in blood, with a continuing decrease in lymphocytes. detected elevated levels of the antagonistic receptor of IL-1 (IL-1Ra) in 14 severe cases of COVID-19, and this marker has been associated with increased viral load, loss of pulmonary function, lung damage, and mortality risk [55] . observed that its expression during infection with an influenza virus had negative effects on CD8 + memory T cells [71] .Various studies of COVID-19 patients have detected elevated IL-4 levels as part of the cytokine storm associated with severe respiratory symptoms [16, 17, 43, 72] . Elevated IL-17 levels have been reported in patients with SARS-CoV-2 as part of the cytokine storm [17] , and they have been associated with the viral load and disease severity [56] . abstract: COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19. url: https://www.sciencedirect.com/science/article/pii/S135961012030109X?v=s5 doi: 10.1016/j.cytogfr.2020.06.001 id: cord-304972-aktfbriw author: Cots, Josep M. title: Recommendations for Management of Acute Pharyngitis in Adults date: 2015-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Acute pharyngitis in adults is one of the most common infectious diseases seen in general practitioners’ consultations. Viral aetiology is the most common. Among bacterial causes, the main agent is Streptococcus pyogenes or group A β-haemolytic streptococcus (GABHS), which causes 5%–30% of the episodes. In the diagnostic process, clinical assessment scales can help clinicians to better predict suspected bacterial aetiology by selecting patients who should undergo a rapid antigen detection test. If these techniques are not performed, an overdiagnosis of streptococcal pharyngitis often occurs, resulting in unnecessary prescriptions of antibiotics, most of which are broad spectrum. Consequently, management algorithms that include the use of predictive clinical rules and rapid tests have been set up. The aim of the treatment is speeding up symptom resolution, reducing the contagious time span and preventing local suppurative and non-suppurative complications. Penicillin and amoxicillin are the antibiotics of choice for the treatment of pharyngitis. The association of amoxicillin and clavulanate is not indicated as the initial treatment of acute infection. Neither are macrolides indicated as first-line therapy; they should be reserved for patients allergic to penicillin. The appropriate diagnosis of bacterial pharyngitis and proper use of antibiotics based on the scientific evidence available are crucial. Using management algorithms can be helpful in identifying and screening the cases that do not require antibiotic therapy. url: https://api.elsevier.com/content/article/pii/S2173573515000423 doi: 10.1016/j.otoeng.2015.05.003 id: cord-025172-qg3jxgch author: Covarrubias, Jose title: Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis date: 2020-05-24 words: 2816.0 sentences: 154.0 pages: flesch: 51.0 cache: ./cache/cord-025172-qg3jxgch.txt txt: ./txt/cord-025172-qg3jxgch.txt summary: We hypothesized mortality and rates of infectious and inflammatory complications would be higher in HIV positive (HIV+) trauma patients. We hypothesized that a HIV+ trauma cohort would have increased mortality rates, infectious complications (i.e., pneumonia, urinary tract infection (UTI), and sepsis), and inflammatory complications [i.e., acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI)], compared to a propensity-matched HIV− group. TQIP patient inclusion criteria consists of age ≥ 16, presence of at least one valid trauma International Statistical Classification of Diseases and Related Health Problems (ICD) diagnosis code, blunt or penetrating mechanisms of injury, Abbreviated Injury Scale (AIS) score ≥ 3, and having data for hospital or emergency department disposition [13] . Using seven years of data derived from the TQIP database, we demonstrated no differences in mortality or rates of infectious complications between HIV+ and HIV− trauma patients. abstract: BACKGROUND: Given the growing number of people worldwide living with huma immunodeficiency virus (HIV), a larger subset of these patients are now susceptible to sustaining a traumatic injury. However, the impact of HIV on outcomes in trauma with modern antiretroviral treatment remains unclear. We hypothesized mortality and rates of infectious and inflammatory complications would be higher in HIV positive (HIV+) trauma patients. METHODS: The Trauma Quality Improvement Program was queried to identify trauma patients ≥ 18 years of age with HIV. Due to the imbalance between HIV+ and HIV negative (HIV−) trauma patients, a 1:2 propensity-matched model was utilized. Matched variables included age, injury severity score, mechanism of injury, systolic blood pressure, pulse rate, Glasgow Coma Scale score, and patient comorbidities. RESULTS: 84 HIV+ patients were matched to 168 HIV− patients. Compared to HIV− patients, HIV+ patients had no significant differences in mortality rate (9.5% vs. 4.8%, p = 0.144) or infectious complications, including pneumonia (6.0% vs. 4.2%, p = 0.530), urinary tract infection (1.2% vs. 1.2%, p = 1.000), or severe sepsis (1.2% vs. 0.0%, p = 0.156). However, higher rates of acute respiratory distress syndrome (ARDS) (9.5% vs. 0.6%, p < 0.001) and acute kidney injury (AKI) (4.8% vs. 0.0%, p = 0.004) were observed. CONCLUSION: HIV+ trauma patients are not at higher risk of mortality or infectious complications, likely due to the advent and prevalence of combination antiretroviral therapy. However, HIV positivity appears to increase the risk of AKI and ARDS in trauma patients. Further research is needed to confirm this finding to elucidate the etiology underlying this association. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246034/ doi: 10.1007/s00068-020-01402-4 id: cord-261980-bm0benu2 author: Cox, Mougnyan title: Neuroendovascular Treatment of Acute Stroke during Covid-19: A Guide from the Frontlines date: 2020-05-29 words: 2751.0 sentences: 111.0 pages: flesch: 46.0 cache: ./cache/cord-261980-bm0benu2.txt txt: ./txt/cord-261980-bm0benu2.txt summary: In this paper, we detail our experience with mechanical thrombectomy for acute stroke during this time when any patient could potentially be COVID positive. It remains to be seen whether this increase in the number of acute stroke patients with LVO requiring mechanical thrombectomy will be sustained, but the effects are the same with respect to time and effort on the part of nursing and the rest of the neurointerventional team. Almost all of the patients undergoing mechanical thrombectomy during the month of April at our institution were of unknown COVID-19 status at the time of intervention, requiring significant modifications to our usual workflow to accommodate the necessities of infection control. Our single-institution experience shows that acute stroke patients with LVO are at least as high and likely higher than during the pre-COVID era, with increasing demands on nursing and the rest of the neurointerventional staff to adequately care for these patients while minimizing exposure to themselves and others. abstract: Since the initial reports surfaced of a novel Coronavirus causing illness and loss of life in Wuhan, China, COVID-19 has rapidly spread across the globe infecting millions and leaving hundreds of thousands dead. As hospitals cope with the influx of COVID-19 patients, new challenges have arisen as healthcare systems care for COVID-19 patients while still providing essential emergency care for patients with acute strokes and acute myocardial infarction. Adding to this complex scenario are new reports that COVID-19 patients are at increased risk of thromboembolic complications including strokes. In this paper, we detail our experience caring for acute stroke patients, and provide some insight into neurointerventional workflow modifications that have helped us adapt to the COVID-19 era. url: https://www.sciencedirect.com/science/article/pii/S1546084320300882?v=s5 doi: 10.1016/j.jradnu.2020.05.007 id: cord-349360-dv4lxx52 author: Cozza, Valerio title: I-ACTSS-COVID-19—the Italian acute care and trauma surgery survey for COVID-19 pandemic outbreak date: 2020-06-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: ABSTRACT: The sudden COVID-19 outbreak in Italy has challenged our health systems and doctors faced the challenge of treating a large number of critically ill patients in a short time interval. Acute care surgeons, although not directly involved in treating COVID-19 + patients, have often modified their daily activity to help in this crisis. We have designed the first Italian survey on the effect of COVID-19 outbreak on Acute Care Surgery activity and submitted it to emergency surgeons in all the country to evaluate the experiences, trends, attitudes and possible educational outcomes that this emergency brought to light. A total of 532 valid surveys were collected during the study period. Lombardy and Lazio had the major answer rate. 96% of responders noticed a decrease in surgical emergencies. The outbreak affected regions and hospitals in different ways depending on the local incidence of infection. Half of responders modified their approach to intra-abdominal infections towards a more conservative treatment. 43% of responders, mainly in the North, were shifted to assist non-surgical patients. There has been a direct but non-homogeneous involvement of emergency surgeons. Almost all hospitals have responded with specific pathways and training. Both emergency surgery and trauma activity have changed and generally decreased but the majority of surgeons have operated on suspected COVID-19 patients. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13304-020-00832-4) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32583216/ doi: 10.1007/s13304-020-00832-4 id: cord-348881-w0moe21t author: Creel-Bulos, Christina title: Acute Cor Pulmonale in Critically Ill Patients with Covid-19 date: 2020-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1056/nejmc2010459 doi: 10.1056/nejmc2010459 id: cord-322957-clf8f90t author: Crespo, Javier title: Resumption of activity in gastroenterology departments. Recommendations by SEPD, AEEH, GETECCU and AEG date: 2020-04-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The set of measures proposed by SEPD, AEEH, GETECCU and AEG are aimed to help departments in their resumption of usual activity. We have prepared a number of practical recommendations regarding patient management and the stepwise resumption of healthcare activity. These recommendations are based on the sparse, changing evidence available, and will be updated in the future according to daily needs and the availability of expendable materials to suit them; in each department they will be implemented depending upon the cumulative incidence of SARS-CoV-2 infection in each region, and the burden the pandemic has represented for each hospital. The general objectives of these recommendations include: • To protect our patients against the risks of infection with SARS-CoV-2 and to provide them with high-quality care. • To protect all healthcare professionals against the risks of infection with SARS-CoV-2. • To resume normal functioning of our departments in a setting of ongoing risk for infection with SARS-CoV-2. url: https://api.elsevier.com/content/article/pii/S2444382420300717 doi: 10.1016/j.gastre.2020.04.001 id: cord-018714-i291z2ju author: Criado, Paulo Ricardo title: Adverse Drug Reactions date: 2016-12-31 words: 23904.0 sentences: 1177.0 pages: flesch: 38.0 cache: ./cache/cord-018714-i291z2ju.txt txt: ./txt/cord-018714-i291z2ju.txt summary: • If possible identify the physiopathologic mechanism involved in the reaction; • Identify as rapidly as possible the drug inducing the reaction and always opt for its withdrawal; in some circumstances the choice is difficult as there is no alternative drug and its use is essential for the maintenance of life; • A careful and intensive observation is recommended for the occurrence of warning signs regarding the appearance of a potentially severe adverse drug reaction, especially in relation to mucous, oral, ocular, and genital involvement and progression of any present cutaneous eruption; • It is imperative that the drug responsible may be withdrawn on a permanent basis together with chemically related com-pounds, and this advice is also valid for first-degree relatives who can present the same type of reaction. abstract: Adverse events and adverse drug reactions are common in clinical practice. Side effects range from the common to the rare and may be confused with other mucocutaneous manifestations resulting from several medications to treat infections, other medical conditions, and in the clinical setting of oncologic treatment. The objective of this chapter to review current data on adverse drug reactions, here classified as (i) severe adverse drug reactions, (ii) uncomplicated cutaneous adverse drug reactions, and (iii) adverse drug reactions caused by chemotherapy drugs, particularly those cases whereby the dermatologist is requested to issue a report and asked to comment on the safety and viability of readministration of a specific drug. We describe aspects associated with these events, presenting a detailed analysis of each of them. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123670/ doi: 10.1007/978-3-319-33919-1_26 id: cord-321697-yua3apfi author: Crigna, Adriana Torres title: Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope? date: 2020-10-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Interest in the use of cell-free nucleic acids (CFNAs) as clinical non-invasive biomarker panels for prediction and prevention of multiple diseases has greatly increased over the last decade. Indeed, circulating CFNAs are attributable to many physiological and pathological processes such as imbalanced stress conditions, physical activities, extensive apoptosis of different origin, systemic hypoxic-ischemic events and tumour progression, amongst others. This article highlights the involvement of circulating CFNAs in local and systemic processes dealing with the question, whether specific patterns of CFNAs in blood, their detection, quantity and quality (such as their methylation status) might be instrumental to predict a disease development/progression and could be further utilised for accompanying diagnostics, targeted prevention, creation of individualised therapy algorithms, therapy monitoring and prognosis. Presented considerations conform with principles of 3P medicine and serve for improving individual outcomes and cost efficacy of medical services provided to the population. url: https://doi.org/10.1007/s13167-020-00226-x doi: 10.1007/s13167-020-00226-x id: cord-306646-6c7n0xir author: Crimi, Claudia title: Resumption of Respiratory Outpatient Services in the COVID-19 era: experience from Southern Italy date: 2020-07-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 pandemic turned the entire health-care system organization upside-down, suspending elective activities and outpatient services. In Italy, we are entering a second phase of the pandemic and several strategies has been developed to “re-open” the country, some businesses, and also health-care outpatient activities. This manuscript describes the experience of a Southern Italy Respiratory Unit for safely resuming outpatient respiratory services and preventing COVID-19 transmission. url: https://api.elsevier.com/content/article/pii/S0196655320306337 doi: 10.1016/j.ajic.2020.06.210 id: cord-310974-hz37yf39 author: Crolley, Valerie E. title: COVID-19 in cancer patients on systemic anti-cancer therapies: outcomes from the CAPITOL (COVID-19 Cancer PatIenT Outcomes in North London) cohort study date: 2020-10-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Patients with cancer are hypothesised to be at increased risk of contracting COVID-19, leading to changes in treatment pathways in those treated with systemic anti-cancer treatments (SACT). This study investigated the outcomes of patients receiving SACT to assess whether they were at greater risk of contracting COVID-19 or having more severe outcomes. METHODS: Data was collected from all patients receiving SACT in two cancer centres as part of CAPITOL (COVID-19 Cancer PatIenT Outcomes in North London). The primary outcome was the effect of clinical characteristics on the incidence and severity of COVID-19 infection in patients on SACT. We used univariable and multivariable models to analyse outcomes, adjusting for age, gender and comorbidities. RESULTS: A total of 2871 patients receiving SACT from 2 March to 31 May 2020 were analysed; 68 (2.4%) were diagnosed with COVID-19. Cancer patients receiving SACT were more likely to die if they contracted COVID-19 than those who did not [adjusted (adj.) odds ratio (OR) 9.84; 95% confidence interval (CI) 5.73–16.9]. Receiving chemotherapy increased the risk of developing COVID-19 (adj. OR 2.99; 95% CI = 1.72–5.21), with high dose chemotherapy significantly increasing risk (adj. OR 2.36, 95% CI 1.35–6.48), as did the presence of comorbidities (adj. OR 2.29; 95% CI 1.19–4.38), and having a respiratory or intrathoracic neoplasm (adj. OR 2.12; 95% CI 1.04–4.36). Receiving targeted treatment had a protective effect (adj. OR 0.53; 95% CI 0.30–0.95). Treatment intent (curative versus palliative), hormonal- or immunotherapy and solid versus haematological cancers had no significant effect on risk. CONCLUSION: Patients on SACT are more likely to die if they contract COVID-19. Those on chemotherapy, particularly high dose chemotherapy, are more likely to contract COVID-19, while targeted treatment appears to be protective. url: https://www.ncbi.nlm.nih.gov/pubmed/33178336/ doi: 10.1177/1758835920971147 id: cord-323092-j2u0ny2u author: Crosby, James C. title: COVID‐19: A review of therapeutics under investigation date: 2020-04-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID‐19 outbreak has disrupted global health care networks and caused thousands of deaths and an international economic downturn. Multiple drugs are being used on patients with COVID‐19 based on theoretical and in vitro therapeutic targets. Several of these therapies have been studied, but many have limited evidence behind their use, and clinical trials to evaluate their efficacy are either ongoing or have not yet begun. This review summarizes the existing evidence for medications currently under investigation for treatment of COVID‐19, including remdesivir, chloroquine/hydroxychlorquine, convalescent plasma, lopinavir/ritonavir, IL‐6 inhibitors, corticosteroids, and angiotensin‐converting enzyme inhibitors. url: https://www.ncbi.nlm.nih.gov/pubmed/32838367/ doi: 10.1002/emp2.12081 id: cord-292335-al6v3b9x author: Crotty, Matthew P. title: Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship date: 2015-11-18 words: 4443.0 sentences: 224.0 pages: flesch: 34.0 cache: ./cache/cord-292335-al6v3b9x.txt txt: ./txt/cord-292335-al6v3b9x.txt summary: METHOD: This was a single-center retrospective cohort study to evaluate the impact of antibacterials in viral pneumonia on clinical outcomes and subsequent multidrug-resistant organism (MDRO) infections/colonization. CONCLUSION: This study found that long-course antibacterial use in the setting of viral pneumonia had no impact on clinical outcomes but increased the incidence of subsequent MDRO infection/colonization. The relationship between viral and bacterial respiratory infections creates a difficult situation for clinicians determining the appropriate use of antimicrobials as they treat hospitalized patients with pneumonia while also trying to minimize the development and selection of resistant organisms. This study aimed to describe the use of continued empiric antibacterials in patients with known viral pneumonia and to determine the impact of such therapies on subsequent bacterial infections/colonization and clinical outcomes. This study compared a cohort of 174 patients with viral pneumonia and mixed viral-bacterial infection based on exposure to continued empiric antibacterials after respiratory virus identification. abstract: INTRODUCTION: Respiratory viruses are increasingly recognized as significant etiologies of pneumonia among hospitalized patients. Advanced technologies using multiplex molecular assays and polymerase-chain reaction increase the ability to identify viral pathogens and may ultimately impact antibacterial use. METHOD: This was a single-center retrospective cohort study to evaluate the impact of antibacterials in viral pneumonia on clinical outcomes and subsequent multidrug-resistant organism (MDRO) infections/colonization. Patients admitted from March 2013 to November 2014 with positive respiratory viral panels (RVP) and radiographic findings of pneumonia were included. Patients transferred from an outside hospital or not still hospitalized 72 hours after the RVP report date were excluded. Patients were categorized based on exposure to systemic antibacterials: less than 3 days representing short-course therapy and 3 to 10 days being long-course therapy. RESULTS: A total of 174 patients (long-course, n = 67; short-course, n = 28; mixed bacterial-viral infection, n = 79) were included with most being immunocompromised (56.3 %) with active malignancy the primary etiology (69.4 %). Rhinovirus/Enterovirus (23 %), Influenza (19 %), and Parainfluenza (15.5 %) were the viruses most commonly identified. A total of 13 different systemic antibacterials were used as empiric therapy in the 95 patients with pure viral infection for a total of 466 days-of-therapy. Vancomycin (50.7 %), cefepime (40.3 %), azithromycin (40.3 %), meropenem (23.9 %), and linezolid (20.9 %) were most frequently used. In-hospital mortality did not differ between patients with viral pneumonia in the short-course and long-course groups. Subsequent infection/colonization with a MDRO was more frequent in the long-course group compared to the short-course group (53.2 vs 21.1 %; P = 0.027). CONCLUSION: This study found that long-course antibacterial use in the setting of viral pneumonia had no impact on clinical outcomes but increased the incidence of subsequent MDRO infection/colonization. url: https://doi.org/10.1186/s13054-015-1120-5 doi: 10.1186/s13054-015-1120-5 id: cord-316873-2gwl9m94 author: Crowley, Jerome title: Adult Extracorporeal Membrane Oxygenation Patient Selection During Coronavirus Disease 2019: The Value of a Review Panel During Coronavirus Disease 2019 date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1097/ccm.0000000000004474 doi: 10.1097/ccm.0000000000004474 id: cord-309561-m43v332d author: Cuffaro, Luca title: Dementia care and COVID-19 pandemic: a necessary digital revolution date: 2020-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Due to the COVID-19 pandemic, most memory clinics have had to suspend their activities. On the other hand, international dementia experts have recommended to provide urgently worldwide support for people living with dementia. This situation urges to play out new strategies to guarantee adequate care. Telemedicine and digital technology (DT) devices, such as smartphones, can be very helpful in remote monitoring and care. Technological devices such as videoconference or smartphone apps might be used for follow-up visits and support to patients and caregivers and to acquire digital markers of clinical progression. Hopefully, this dramatic situation would facilitate the process of progressive familiarization of neurologists with telemedicine and DT approach. url: https://www.ncbi.nlm.nih.gov/pubmed/32556746/ doi: 10.1007/s10072-020-04512-4 id: cord-299750-zkrlm3ds author: Cui, Wei title: Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China date: 2010-05-31 words: 4965.0 sentences: 273.0 pages: flesch: 52.0 cache: ./cache/cord-299750-zkrlm3ds.txt txt: ./txt/cord-299750-zkrlm3ds.txt summary: We describe the clinical characteristics and factors associated with the death of patients who were hospitalized with 2009 H1N1 influenza pneumonia in Shenyang, China, from November to December 2009. Therefore, this report summarizes the clinical manifestations, clinical outcomes and the risk factors associated with death in hospitalized pneumonia patients associated with 2009 H1N1 influenza infections in Shenyang, China, during November to December 2009. They used a standardized form that included demographic data, seasonal influenza vaccination history for the previous year, smoking status, underlying medical conditions, clinical signs and symptoms, selected laboratory tests including C reactive protein (CRP), white blood cell classification and count, lactic dehydrogenase (LDH), creatine kinase (CK), glutamic-oxaloacetic transaminase (AST), glutamic alanine aminotransferase (ALT), albumin (Alb), CD4, CD8 and CD3 T cell counts, blood gas analyses, blood or sputum cultures, radiographic findings, intervals between symptom onset and initiation of oseltamivir therapy, treatment course and length of stay. abstract: BACKGROUND: During the spring of 2009, a pandemic influenza A (H1N1) virus emerged and spread globally. We describe the clinical characteristics and factors associated with the death of patients who were hospitalized with 2009 H1N1 influenza pneumonia in Shenyang, China, from November to December 2009. METHODS: We carried out a retrospective chart review of 68 patients who were hospitalized with pneumonia and confirmed to have 2009 H1N1 virus infection by a real time RT-PCR assay of respiratory specimens. RESULTS: Of the 68 patients we studied, 30 (44%) were admitted to an intensive care unit and 10 (14.7%) died. The median age of patients was 41 years (range, 18-66), and only one patient was over 65 years of age. The male to female ratio was 2.78:1 (50:18). Of the 68 patients, 23 (34%) had at least one underlying medical condition, 9 (13%) had a cigarette index ≥400 and 22 (32%) were obese. All patients underwent chest radiography on admission and the findings were consistent with pneumonia in all cases. All patients were treated with oseltamivir and treatment was initiated at a median time of seven days after the onset of illness. The laboratory test results indicated lymphopenia, hypoproteinemia and elevated lactic dehydrogenase and C reactive protein levels. Of the 68 patients, 33 (52%) showed a reduction in CD4 T cell counts. Of the 58 patients who survived, 31 (53%) had lymphopenia and 27 recovered from this condition after five days. Of the 10 patients who died, nine (90%) had lymphopenia and only two patients recovered from this condition after five days. Obesity and recovery from lymphopenia after five days were factors associated with death, as determined by multivariate logistic-regression analysis (obesity, odds ratio = 23.06; lymphocytopenia reversion, odds ration = 28.69). CONCLUSIONS: During the evaluation period in Shenyang, China, 2009 H1N1 influenza caused severe illness requiring hospitalization in 68 patients, 10 (14.7%) of which died. Many of these patients were considered healthy adults and few were elderly (65 years or older). Obesity and lymphopenia, which was not restored after five days of treatment, were factors associated with poor outcomes of 2009 H1N1 influenza infection. url: https://www.ncbi.nlm.nih.gov/pubmed/20513239/ doi: 10.1186/1471-2334-10-145 id: cord-279571-chiadufa author: Cui, Xiaoyang title: Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study date: 2020-07-24 words: 3928.0 sentences: 226.0 pages: flesch: 54.0 cache: ./cache/cord-279571-chiadufa.txt txt: ./txt/cord-279571-chiadufa.txt summary: Compared with patients without AKI, patients with AKI had more severe organ dysfunction, as indicated by a higher level of disease severity status, higher sequential organ failure assessment (SOFA) score on admission, an increased prevalence of shock, and a higher level of respiratory support. CONCLUSION: Our findings show that admission SOFA score was an independent risk factor for AKI in COVID-19 patients, and patients with AKI had higher in-hospital mortality. In particular, acute kidney injury (AKI) is a common, serious complication in critically ill patients, which may result in increased mortality, longer hospital stays, and higher medical costs [5] . The aim of this study was to evaluate the incidence, risk factors, and impact on mortality of AKI in critically ill patients with COVID-19. In our study, AKI patients had a significant higher mortality rate after adjusting for admission SOFA score, severity status, respiratory support method, and shock. abstract: INTRODUCTION: Severe acute respiratory viral infections are frequency accompanied by multiple organ dysfunction, including acute kidney injury (AKI). In December 2019, the coronavirus disease 2019 (COVID-19) outbreak began in Wuhan, Hubei Province, China, and rapidly spread worldwide. While diffuse alveolar damage and acute respiratory failure are the main features of COVID-19, other organs may be involved, and the incidence of AKI is not well described. We assessed the incidence and clinical characteristics of AKI in patients with laboratory-confirmed COVID-19 and its effects on clinical outcomes. METHODS: We conducted a multicenter, retrospective, observational study of patients with COVID-19 admitted to two general hospitals in Wuhan from 5 January 2020 to 21 March 2020. Demographic data and information on organ dysfunction were collected daily. AKI was defined according to the KDIGO clinical practice guidelines. Early and late AKI were defined as AKI occurring within 72 h after admission or after 72 h, respectively. RESULTS: Of the 116 patients, AKI developed in 21 (18.1%) patients. Among them, early and late AKI were found in 13 (11.2%) and 8 (6.9%) patients, respectively. Compared with patients without AKI, patients with AKI had more severe organ dysfunction, as indicated by a higher level of disease severity status, higher sequential organ failure assessment (SOFA) score on admission, an increased prevalence of shock, and a higher level of respiratory support. Patients with AKI had a higher SOFA score on admission (4.5 ± 2.1 vs. 2.8 ± 1.4, OR 1.498, 95% CI 1.047–2.143) and greater hospital mortality (57.1% vs. 12.6%, OR 3.998, 95% CI 1.088–14.613) than patients without AKI in both the univariate and multivariate analyses. Patients with late AKI, but not those with early AKI, had a significantly prolonged length of stay (19.6 vs. 9.6 days, p = 0.015). CONCLUSION: Our findings show that admission SOFA score was an independent risk factor for AKI in COVID-19 patients, and patients with AKI had higher in-hospital mortality. Moreover, AKI development after 72 h of admission was related to prolonged hospitalization time. url: https://www.ncbi.nlm.nih.gov/pubmed/32712607/ doi: 10.1159/000509517 id: cord-352401-tmt1pmw9 author: Curatola, Antonietta title: Use of Handheld Transceiver for Hospital Healthcare Workers-Caregiver Communication During the Coronavirus disease 2019 (COVID-19) Outbreak in Pediatric Emergency Department date: 2020-04-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32287053/ doi: 10.1097/inf.0000000000002689 id: cord-017786-kfl6xt31 author: Curiel-Balsera, Emilio title: Guidelines for Health Organizations: European Perspectives and Experience in Pandemics date: 2013-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In Europe, the rate of noninvasive ventilation (NIV) use in intensive care units (ICUs) is about 35 % for ventilated patients and higher (roughly 60 %) in respiratory ICUs or emergency departments. In North America, this form of ventilation is begun most often in emergency departments (EDs), most patients being transferred to the ICU or step-down units in hospitals with such facilities. This low rate of use in some hospitals is related to scarce knowledge on or experience with this technique, insufficient technical equipment, and inadequate funding. Despite these limitations, NIV is increasingly being used outside traditional and respiratory ICUs, including EDs, postsurgical recovery rooms, cardiology, neurology, and oncology wards, and palliative care units. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122448/ doi: 10.1007/978-3-7091-1496-4_41 id: cord-330359-c0l5xq5m author: Curran, J title: Reducing potential aerosol generation in flexible nasolaryngoscopy: a novel method date: 2020-07-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Fibre-optic nasoendoscopy and fibre-optic laryngoscopy are high-risk procedures in the coronavirus disease 2019 era, as they are potential aerosol-generating procedures. Barrier protection remains key to preventing transmission. METHODS: A device was developed that patients can wear to reduce potential aerosol contamination of the surroundings. CONCLUSION: This device is simple, reproducible, easy to use, economical and well-tolerated. Full personal protection equipment should additionally be worn by the operator. url: https://www.ncbi.nlm.nih.gov/pubmed/32641171/ doi: 10.1017/s0022215120001413 id: cord-314449-ukqux772 author: Curtis, L.T. title: Prevention of hospital-acquired infections: review of non-pharmacological interventions date: 2008-06-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Hospital-acquired (nosocomial) infections (HAIs) increase morbidity, mortality and medical costs. In the USA alone, nosocomial infections cause about 1.7 million infections and 99 000 deaths per year. HAIs are spread by numerous routes including surfaces (especially hands), air, water, intravenous routes, oral routes and through surgery. Interventions such as proper hand and surface cleaning, better nutrition, sufficient numbers of nurses, better ventilator management, use of coated urinary and central venous catheters and use of high-efficiency particulate air (HEPA) filters have all been associated with significantly lower nosocomial infection rates. Multiple infection control techniques and strategies simultaneously (‘bundling’) may offer the best opportunity to reduce the morbidity and mortality toll of HAIs. Most of these infection control strategies will more than pay for themselves by saving the medical costs associated with nosocomial infections. Many non-pharmacological interventions to prevent many HAIs will also reduce the need for long or multiple-drug antibiotic courses for patients. Lower antibiotic drug usage will reduce risk of antibiotic-resistant organisms and should improve efficacy of antibiotics given to patients who do acquire infections. url: https://api.elsevier.com/content/article/pii/S0195670108001503 doi: 10.1016/j.jhin.2008.03.018 id: cord-308169-a0ft6wdy author: Custovic, A. title: EAACI position statement on asthma exacerbations and severe asthma date: 2013-11-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Asthma exacerbations and severe asthma are linked with high morbidity, significant mortality and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function and, in childhood, are linked to development of persistent asthma. This position paper, from the European Academy of Allergy and Clinical Immunology, highlights the shortcomings of current treatment guidelines for patients suffering from frequent asthma exacerbations and those with difficult‐to‐treat asthma and severe treatment‐resistant asthma. It reviews current evidence that supports a call for increased awareness of (i) the seriousness of asthma exacerbations and (ii) the need for novel treatment strategies in specific forms of severe treatment‐resistant asthma. There is strong evidence linking asthma exacerbations with viral airway infection and underlying deficiencies in innate immunity and evidence of a synergism between viral infection and allergic mechanisms in increasing risk of exacerbations. Nonadherence to prescribed medication has been identified as a common clinical problem amongst adults and children with difficult‐to‐control asthma. Appropriate diagnosis, assessment of adherence and other potentially modifiable factors (such as passive or active smoking, ongoing allergen exposure, psychosocial factors) have to be a priority in clinical assessment of all patients with difficult‐to‐control asthma. Further studies with improved designs and new diagnostic tools are needed to properly characterize (i) the pathophysiology and risk of asthma exacerbations, and (ii) the clinical and pathophysiological heterogeneity of severe asthma. url: https://www.ncbi.nlm.nih.gov/pubmed/24410781/ doi: 10.1111/all.12275 id: cord-268843-zml9lbve author: Cuvelier, Geoffrey D.E. title: Clinical presentation, immunologic features, and hematopoietic stem cell transplant outcomes for IKBKB immune deficiency date: 2018-10-31 words: 5812.0 sentences: 253.0 pages: flesch: 39.0 cache: ./cache/cord-268843-zml9lbve.txt txt: ./txt/cord-268843-zml9lbve.txt summary: In the Canadian province of Manitoba, our group has periodically managed young infants of Northern Cree First Nations (Aboriginal) descent presenting with early-onset and life-threatening viral, bacterial, Mycobacterial, and fungal infections, clinically resembling severe combined immune deficiency (SCID). Herein we describe the clinical presentation, immunologic features, and HSCT outcomes for the largest cohort of infants with IKBKB immune deficiency resulting from complete loss of IKKβ expression published to date. Supporting a more profound immune deficiency are the other six reported patients with IKBKB mutations, who also presented with severe bacterial, fungal and viral infections as young infants. Like IKBKB immune deficiency, patients with hypermorphic NFKBIA mutations that result in reduced degradation of IκBα, present with multiple and severe bacterial, fungal and viral infections starting at an early age, typically before 3-months. abstract: IKBKB immune deficiency is a rare but life-threatening primary immunodeficiency disorder, involving activation defects in adaptive and innate immunity. We present sixteen cases of a homozygous IKBKB mutation (c.1292dupG) in infants characterized by early-onset bacterial, viral, fungal and Mycobacterial infections. In most cases, T- and B-cells were quantitatively normal, but phenotypically naïve, with severe hypogammaglobulinemia. T-cell receptor excision circles were normal, meaning newborn screening by TREC analysis would miss IKBKB cases. Although IKBKB immune deficiency does not meet traditional laboratory based definitions for SCID, this combined immune deficiency appears to be at least as profound. Urgent HSCT, performed in eight patients, remains the only known curative therapy, although only three patients are survivors. Ongoing infections after transplant remain a concern, and may be due to combinations of poor social determinants of health, secondary graft failure, and failure of HSCT to replace non-hematopoietic cells important in immune function and dependent upon IKK/NF-κB pathways. url: https://doi.org/10.1016/j.clim.2018.10.019 doi: 10.1016/j.clim.2018.10.019 id: cord-355549-6xnjj5h5 author: Cécile, Couchoud title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date: 2020-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed. url: https://www.sciencedirect.com/science/article/pii/S0085253820309595?v=s5 doi: 10.1016/j.kint.2020.07.042 id: cord-306896-khn8epxd author: D'Souza, Ayman title: Tracheostomy intervention in intubated COVID positive patients: A survey of current clinical practice among ENT surgeons date: 2020-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The COVID‐19 pandemic has resulted in an unprecedented need for critical care intervention. Prolonged intubation and mechanical ventilation has resulted in the need for tracheostomy in some patients. The purpose of this international survey was to assess optimal timing, technique and outcome for this intervention. METHODS: An online survey was generated. Otorhinolaryngologists from both the United Kingdom and Abroad were polled with regards to their experience of tracheostomy in COVID‐19 positive ventilated patients. RESULTS: The survey was completed by 50 respondents from 16 nations. The number of ventilated patients totalled 3403, on average 9.7% required a tracheostomy. This was on average performed on day 14 following intubation. The majority of patients were successfully weaned (mean 7.4 days following tracheostomy). CONCLUSION: The results of this brief survey suggest that tracheostomy is of benefit in selected patients. There was insufficient data to suggest improved outcomes with either percutaneous vs an open surgical technique. url: https://doi.org/10.1002/hed.26274 doi: 10.1002/hed.26274 id: cord-353013-7cx0gnum author: DENG, Pengbo title: Bronchial Fistula: Rare Complication of Treatment with Anlotinib date: 2020-10-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND AND OBJECTIVE: Anlotinib is a newly developed small molecule multiple receptor tyrosine kinase (RTK) inhibitor that was approved for the treatment of patients with lung cancer in China. We aim to report 3 cases of rare complication of anlotinib-bronchial fistula (BF) during the treatment of lung cancer patients and summarize the possible causes. METHODS: We collected three patients who developed BF due to anlotinib treatment, and conducted a search of Medline and PubMed for medical literature published between 2018 and 2020 using the following search terms: "anlotinib, " "lung cancer, " and "fistula." RESULTS: Our literature search produced two case reports (three patients) which, in addition to our three patients. We collated the patients' clinical characteristics including demographic information, cancer type, imaging features, treatment received, risk factors for anlotinib related BF, and treatment-related outcomes. The six patients shared some common characteristics: advanced age, male, concurrent infection symptoms, diabetes mellitus (DM), advanced squamous cell and small cell lung cancers, centrally located tumors, tumor measuring ≥5 cm in longest diameter, and newly formed tumor cavitation after multi-line treatment especially after receiving radiotherapy. Fistula types included broncho-pericardial fistula, broncho-pleural fistula, and esophago-tracheobronchial fistula. Six patients all died within 6 months. CONCLUSION: Although anlotinib is relatively safe, it is still necessary to pay attention to the occurrence of BF, a rare treatment side effect that threatens the quality of life and overall survival of patients. Anlotinib, therefore, requires selective use and close observation of high-risk patients. url: https://doi.org/10.3779/j.issn.1009-3419.2020.102.40 doi: 10.3779/j.issn.1009-3419.2020.102.40 id: cord-258402-9s57thvn author: Dabas, Vineet title: Management of Orthopaedic Accidental Emergencies Amidst COVID-19 Pandemic: Our Experience in Preparing to Live with Corona date: 2020-09-10 words: 3703.0 sentences: 193.0 pages: flesch: 51.0 cache: ./cache/cord-258402-9s57thvn.txt txt: ./txt/cord-258402-9s57thvn.txt summary: INTRODUCTION: With increasing prevalence of coronavirus cases (including among health care providers), the current advice for orthopaedic surgeons is to favor non-operative management of most injuries and reduce face-to-face follow-up. The standard operating procedures (SOPs) were implemented which were based upon the recommendations of ICMR, Ministry of Health and Family Welfare, GOI and Indian Orthopaedic Association (IOA) [10] , and targeted to provide optimum healthcare at a minimum risk to the treating team as well as other patients admitted to the hospital. Among the non-COVID-19 suspects, who were shifted to non-isolation zone, those who could be managed conservatively were given adequate primary treatment like fluids, analgesics and splintage and were discharged at the earliest so as to minimize the risk of infection transmission to them as well as health care workers. abstract: INTRODUCTION: With increasing prevalence of coronavirus cases (including among health care providers), the current advice for orthopaedic surgeons is to favor non-operative management of most injuries and reduce face-to-face follow-up. We present our experience in managing the patients at Government-run non-COVID-19 trauma center in Delhi in an algorithmic form. Our standard operating protocols were mainly based on recommendations of Indian Orthopaedic Association and targeted to provide healthcare at a minimum risk to the treating team as well as other patients admitted to the hospital. METHODOLOGY: We describe the inflow, in-hospital management and outflow of patients at our facility during the lockdown period and in the following unlock period (from 23 March to 8 July 2020). Those patients who had absolute indications for surgery were offered surgery, while conservative treatment was more favored in those with relative indications. We also highlight the changes incorporated in OT settings as well as in rehabilitative and follow-up period. RESULTS: Following the described protocol helped us maintain a balance between the safety of patients and our front line workers which was evident by very low COVID-19-positive rate in admitted patients (4.22%) and health care providers (16.67%) in the above-mentioned time period. CONCLUSIONS: We need to be prepared to cohabitate with this deadly Novel Coronavirus and adapt our surgical practices according to the need of the hour by minimizing surgical indications and strengthening the training in conservative principles. url: https://www.ncbi.nlm.nih.gov/pubmed/32934420/ doi: 10.1007/s43465-020-00252-x id: cord-343917-67qjqxqh author: Dabrowska, Dominika title: Staying Ahead of the Curve: Modified Approach to Emergency Caesarean Section Under General Anaesthesia in COVID-19 Pandemic date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The recent outbreak of SARS-CoV-2 has prompted healthcare professionals to re-design and modify the standards of care and operating procedures relevant to dealing with suspected or confirmed cases of COVID-19. The aim of this review is to highlight the key recommendations related to obstetric anaesthesia from scientific bodies in the United Kingdom and United States and to summarize recently developed and implemented clinical pathways for care of obstetric patients – specifically those requiring urgent general anaesthesia for caesarean section within a large maternity unit in London. The need to perform an emergency operative delivery in a timely manner while ensuring clinicians are suitably equipped and protected represents a uniquely challenging scenario, given the higher risk of viral transmission with aerosol generating procedures. In these settings, emphasis needs to be put on meticulous preparation, safety checklists and specific equipment and staffing adjustments. We present a structured framework comprised of four critical steps aimed to facilitate the development of local strategies and protocols. url: https://doi.org/10.5152/tjar.2020.280420 doi: 10.5152/tjar.2020.280420 id: cord-035316-l4qbiuuu author: Dacie, Ruth title: Spontaneous Aortic Haematoma in a Patient Receiving Adjuvant Folinic Acid, 5-Fluorouracil, Irinotecan, and Oxaliplatin Chemotherapy Following Resection of a Pancreatic Adenocarcinoma date: 2020-10-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This case report describes the finding of a spontaneous aortic haematoma in a patient receiving adjuvant folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) chemotherapy following resection of a pancreatic adenocarcinoma. The haematoma was thought to have arisen secondary to a chemotherapy-induced vasculitis affecting the aorta, as the patient had no other risk factors for de novo aortitis or aortic haematoma. There have been several previously documented cases of associations between chemotherapy agents (in particular platinum-based agents) and vasculitis. This report includes computed tomography (CT) images and a discussion of the literature of related cases. This case is a good example of rare vascular toxicities arising from chemotherapy, the impact such rare complications have upon further chemotherapy options, and how these should be discussed when consenting patients for chemotherapy due to the potentially life-threatening complications. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657317/ doi: 10.7759/cureus.10908 id: cord-264543-b4zwinh2 author: Daher, Valéria Barcelos title: Anosmia: A marker of infection by the new corona virus date: 2020-06-12 words: 1719.0 sentences: 99.0 pages: flesch: 51.0 cache: ./cache/cord-264543-b4zwinh2.txt txt: ./txt/cord-264543-b4zwinh2.txt summary: [4] The objective of this case report is to describe anosmia and ageusia as emergent initial symptoms of COVID-19 (Coronavirus Disease 2019). After clinical diagnosis, it was instituted home treatment with Oseltamivir 75 mg an oral tablet every 12 hours for five days, Azithromycin 500mg, one oral tablet per day for five days, Acetylcysteine syrup 40mg /ml 15 ml orally at night for 5 days and dipyrone if pain or fever, resulting in marked improvement of the signals and symptoms presented by the patient in five days, however, with persistence of anosmia and ageusia. In the case described, the patient presented as initial symptoms anosmia (absence of smell) and ageusia (change in taste) followed by odynophagia, cough, low fever, chest pain and mild respiratory distress, so it was considered suggestive of Covid-19 and confirmed, later, by the laboratory examination (RT-PCR) of the patient. [6] This examination was performed on the patient of the case at the time of the diagnosis and during the anosmia period and showed no structural changes. abstract: The diagnosis of Coronavirus Disease 2019 (COVID-19) is based on the identification of common symptoms such as fever, tiredness and dry cough. Anosmia and ageusia are also in fact symptoms of the infection with the new coronavirus and recently were considered as symptoms by the World Health Organization. In this case report we present the new onset anosmia during the COVID-19 pandemic. The patient, 31-year-old, reported olfactory and gustatory dysfunctions as initial symptoms of mild-to-moderate form of the COVID-19. Therefore, chemosensory dysfunctions should serve as a warning to health professionals as a possible marker of infection with the new corona virus. url: https://doi.org/10.1016/j.rmcr.2020.101129 doi: 10.1016/j.rmcr.2020.101129 id: cord-026392-cvb44v5v author: Dahlberg, Jørgen title: Barriers and challenges in the process of including critically ill patients in clinical studies date: 2020-06-08 words: 4780.0 sentences: 256.0 pages: flesch: 49.0 cache: ./cache/cord-026392-cvb44v5v.txt txt: ./txt/cord-026392-cvb44v5v.txt summary: RESULTS: Among 279 eligible critically ill patients, 204 (73%) were omitted from the study due to challenges and barriers in the inclusion process. Previous studies have identified obstacles when performing research in critically ill patients at intensive care units (ICU) related to challenges in the recruitment process [1] [2] [3] [4] . The legislation and clinical practice vary across the world, and a prior PubMed search did not disclose any resent Scandinavian research covering the overall barriers and challenges in the process of including critically ill patients in clinical studies. The purpose of this study was to identify practical, medical, legal or ethical barriers and challenges in the process of including critically ill patients in the Norwegian Intensive Care Unit Dalteparin Effect (NORIDES) study. The study revealed that most critically ill patients at ICU were unable to provide written, informed consent for study participation. abstract: BACKGROUND: Clinical research in severely ill or injured patients is required to improve healthcare but may be challenging to perform in practice. The aim of this study was to analyse barriers and challenges in the process of including critically ill patients in clinical studies. METHODS: Data from critically ill patients considered for inclusion in an observational study of venous thromboembolism in Norway were analysed. This included quantitative and qualitative information from the screening log, consent forms and research notes. RESULTS: Among 279 eligible critically ill patients, 204 (73%) were omitted from the study due to challenges and barriers in the inclusion process. Reasons for omission were categorised as practical in 133 (65%), medical in 31 (15%), and legal or ethical in 40 (20%) of the patients. Among 70 included patients, 29 (41%) consents were from patients and 41 (59%) from their next of kin. Several challenges were described herein; these included whether patients were competent to give consent, and which next of kin that should represent the patient. Furthermore, some included patients were unable to recall what they have consented, and some appeared unable to separate research from treatment. CONCLUSIONS: Barriers and challenges in the inclusion process led to the omission of near three out of four eligible patients. This analysis provided information about where the problem resides and may be solved. The majority of challenges among included patients were related to issues of autonomy and validity of consent. TRIAL REGISTRATION: ClinicalTrials.gov (NCT03405766). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276963/ doi: 10.1186/s13049-020-00732-x id: cord-338192-2v9dbc9h author: Dai, J. D. title: How many patients will need ventilators tomorrow? date: 2020-05-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This paper develops an algorithm to predict the number of Covid-19 patients who will start to use ventilators tomorrow. This algorithm is intended to be utilized by a large hospital or a group of coordinated hospitals at the end of each day (e.g. 8pm) when the current number of non-ventilated Covid-19 patients and the predicated number of Covid-19 admissions for tomorrow are available. The predicted number of new admissions can be replaced by the numbers of Covid-19 admissions in the previous d days (including today) for some integer d [≥] 1 when such data is available. In our simulation model that is calibrated with New York City's Covid-19 data, our predictions have consistently provided reliable estimates of the number of the ventilator-starts next day. This algorithm has been implemented through a web interface at covidvent.github.io, which is available for public usage. Utilizing this algorithm, our paper also suggests a ventilator ordering and returning policy. The policy will dictate at the end of each day how many ventilators should be ordered tonight from a central stockpile so that they will arrive by tomorrow morning and how many ventilators should be returned tomorrow morning to the central stockpile. In 100 runs of operating our ventilator order and return policy, no patients were denied of ventilation and there was no excessive inventory of ventilators kept at hospitals. url: https://doi.org/10.1101/2020.05.18.20105783 doi: 10.1101/2020.05.18.20105783 id: cord-266079-nv28ppft author: Dai, Jinghong title: Corticosteroid treatment in severe COVID-19 pneumonia: two cases and literature review date: 2020-05-25 words: 2384.0 sentences: 141.0 pages: flesch: 41.0 cache: ./cache/cord-266079-nv28ppft.txt txt: ./txt/cord-266079-nv28ppft.txt summary: Coronavirus disease 2019 (COVID-19) pneumonia, firstly reported in Wuhan, Hubei province, China, has rapidly spread around the world with high mortality rate among critically ill patients. In the following sections, we present two representative confirmed severe COVID-19 cases according to WHO interim guidance [1] who have received corticosteroid treatment during their hospitalization. Clark Russell and his colleagues [4] summarized the available clinical evidence on corticosteroid therapy in severe COVID-19 [5] , Middle East respiratory syndrome (MERS) [6] and influenza [7] against corticosteroid use in 2019 novel coronavirus pneumonia, except in the setting of a clinical trial. Reports showed that the proper use of corticosteroids could reduce the mortality of critically ill SARS patients and shorten their hospital stay without causing secondary infections and other complications [8] . reported that methylprednisolone treatment might be beneficial for patients with COVID-19 who developed acute respiratory distress syndrome (ARDS) [10] . abstract: Coronavirus disease 2019 (COVID-19) pneumonia, firstly reported in Wuhan, Hubei province, China, has rapidly spread around the world with high mortality rate among critically ill patients. The use of corticosteroids in COVID-19 remains a major controversy. Available evidences are inconclusive. According to WHO guidance, corticosteroids are not recommended to be used unless for another reason. Chinese Thoracic Society (CTS) proposes an expert consensus statement that suggests taking a prudent attitude of corticosteroid usage. In our clinical practice, we do not use corticosteroids routinely; only low-to-moderate doses of corticosteroids were given to several severely ill patients prudently. In this paper, we will present two confirmed severe COVID-19 cases admitted to isolation wards in Optical Valley Campus of Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology. We will discuss questions related to corticosteroids usages. url: https://www.ncbi.nlm.nih.gov/pubmed/32451729/ doi: 10.1007/s10067-020-05172-7 id: cord-310010-oxgb6xnv author: Dalmau, Josep title: “Time to recharge” date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1212/nxi.0000000000000779 doi: 10.1212/nxi.0000000000000779 id: cord-270388-nozh463l author: Damiani, M. title: Extracorporeal Cytokine Hemadsorption in Severe COVID-19 Respiratory Failure date: 2020-06-29 words: 1051.0 sentences: 73.0 pages: flesch: 53.0 cache: ./cache/cord-270388-nozh463l.txt txt: ./txt/cord-270388-nozh463l.txt summary: Despite the extracorporeal cytokine hemadsorption device CytoSorb was granted FDA emergency approval for critically ill COVID19 patients, to our knowledge no published studies are currently available to support its use. 4 An alternative treatment able to reduce circulating cytokines in critically ill patients is CytoSorb (Aferetica srl, Italy), a device containing adsorbent polymer beads designed to irreversibly remove cytokines currently used for septic shock and other conditions where elevated levels of cytokines are present. Despite the lack of published results, based on bench performance testing and reported clinical experience, CytoSorb was granted FDA emergency approval for critically ill SARS-CoV-2 patients on April 10, 2020. . https://doi.org/10.1101/2020.06.28.20133561 doi: medRxiv preprint C-reactive protein (CRP) levels and respiratory parameters including the PaO2/FiO2 ratio (P/F) were assessed daily. Further studies are required to assess if CytoSorb can improve the clinical outcome of critically ill patients. abstract: Despite the extracorporeal cytokine hemadsorption device CytoSorb was granted FDA emergency approval for critically ill COVID19 patients, to our knowledge no published studies are currently available to support its use. This manuscript reports the experience of the use of CytoSorb during COVID19 pandemic in Bergamo, Italy. In our pilot study, eleven COVID19 patients requiring invasive mechanical ventilation for a rapidly progressive ARDS were treated with 24 to 48 hours of extracorporeal cytokine hemadsorption. Respiratory and laboratory parameters, including a full set of inflammatory cytokines, were evaluated at different time points. A significant but transient reduction of the hyperinflammatory status was observed, along with the amelioration of the clinical and respiratory parameters. url: https://doi.org/10.1101/2020.06.28.20133561 doi: 10.1101/2020.06.28.20133561 id: cord-290750-85731og8 author: Danese, Silvio title: Management of IBD during the COVID-19 outbreak: resetting clinical priorities date: 2020-03-25 words: 1798.0 sentences: 86.0 pages: flesch: 49.0 cache: ./cache/cord-290750-85731og8.txt txt: ./txt/cord-290750-85731og8.txt summary: Because of the very high transmission capacity, the WHO declared the outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection a public health emergency of international concern. Additional recommendations for patients with IBD from the IOIBD: • Medicines such as mesalamine are safe • If possible, withdraw from steroid use • Biologic agents used to treat IBD (e.g. anti-TNF agents, ustekinumab and vedolizumab) are generally safe; there are no recommendations to stop taking these medications and the effects of these drugs are present for many months • Thiopurines and tofacitinib tend to inhibit the immune response to viral infections, but stopping these agents in the short-term will not help • Get the influenza vaccination • Stay at home and minimize social contact c | Strategies to enable maintenance of our biologic agent clinic during the COVID-19 outbreak in Italy include checkpoints at hospital entrances for symptom screening and use of surgical masks for clinical staff and patients. abstract: The coronavirus disease (COVID-19) worldwide outbreak has led to a dramatic challenge for all healthcare systems, including inflammatory bowel disease (IBD) centres. Here, we describe the fast changes and clinical issues that IBD specialists could face during this SARS-CoV-2 infection pandemic, highlighting the potential rearrangements of care and resetting of clinical priorities. url: https://doi.org/10.1038/s41575-020-0294-8 doi: 10.1038/s41575-020-0294-8 id: cord-307285-bxy0zsc7 author: Dar Odeh, Najla title: COVID-19: Present and Future Challenges for Dental Practice date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 was declared a pandemic by the World Health Organization, with a high fatality rate that may reach 8%. The disease is caused by SARS-CoV-2 which is one of the coronaviruses. Realizing the severity of outcomes associated with this disease and its high rate of transmission, dentists were instructed by regulatory authorities, such as the American Dental Association, to stop providing treatment to dental patients except those who have emergency complaints. This was mainly for protection of dental healthcare personnel, their families, contacts, and their patients from the transmission of virus, and also to preserve the much-needed supplies of personal protective equipment (PPE). Dentists at all times should competently follow cross-infection control protocols, but particularly during this critical time, they should do their best to decide on the emergency cases that are indicated for dental treatment. Dentists should also be updated on how this pandemic is related to their profession in order to be well oriented and prepared. This overview will address several issues concerned with the COVID-19 pandemic that directly relate to dental practice in terms of prevention, treatment, and orofacial clinical manifestations. url: https://www.ncbi.nlm.nih.gov/pubmed/32366034/ doi: 10.3390/ijerph17093151 id: cord-336194-5v395xae author: Darafsheh, Arash title: Mitigating disruptions, and scalability of radiation oncology physics work during the COVID‐19 pandemic date: 2020-05-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: The COVID‐19 pandemic has led to disorder in work and livelihood of a majority of the modern world. In this work, we review its major impacts on procedures and workflow of clinical physics tasks, and suggest alternate pathways to avoid major disruption or discontinuity of physics tasks in the context of small, medium, and large radiation oncology clinics. We also evaluate scalability of medical physics under the stress of “social distancing”. METHODS: Three models of facilities characterized by the number of clinical physicists, daily patient throughput, and equipment were identified for this purpose. For identical objectives of continuity of clinical operations, with constraints such as social distancing and unavailability of staff due to system strain, however with the possibility of remote operations, the performance of these models was investigated. General clinical tasks requiring on‐site personnel presence or otherwise were evaluated to determine the scalability of the three models at this point in the course of disease spread within their surroundings. RESULTS: The clinical physics tasks within three models could be divided into two categories. The former, which requires individual presence, include safety‐sensitive radiation delivery, high dose per fraction treatments, brachytherapy procedures, fulfilling state and nuclear regulatory commission's requirements, etc. The latter, which can be handled through remote means, include dose planning, physics plan review and supervision of quality assurance, general troubleshooting, etc. CONCLUSION: At the current level of disease in the United States, all three models have sustained major system stress in continuing reduced operation. However, the small clinic model may not perform if either the current level of infections is maintained for long or staff becomes unavailable due to health issues. With abundance, and diversity of innovative resources, medium and large clinic models can sustain further for physics‐related radiotherapy services. url: https://doi.org/10.1002/acm2.12896 doi: 10.1002/acm2.12896 id: cord-314171-431buxxr author: Dariya, Begum title: Understanding novel COVID-19: its impact on organ failure and risk assessment for diabetic and cancer patients date: 2020-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The current pandemic outbreak of COVID-19 originated from Wuhan, China. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significant mortality and morbidity rate. The severe risk factors are commonly detected in patients of older age and with medical comorbidities like cancer and diabetes. Scientists and doctors have scrambled to gain knowledge about the novel virus and its pathophysiology in order to discover possible therapeutic regimens and vaccines for COVID-19. The therapeutic strategies like targeting the viral genome emphasize the promising approach to target COVID-19. Additionally, blocking the receptor, ACE2 via the neutralizing antibodies for viral escape that prevents it from entering into the cells provides another therapeutic regimen. In this review article, we have presented the effect of SARS-CoV-2 infection in comorbid patients and discussed organ failure caused by this virus. Based on the data available from the scientific literature and ongoing clinical trials, we have focused on therapeutic strategies. We hope that we would fill the gaps that puzzled the researchers and clinicians with the best of our knowledge collected for the betterment of the patients for the coming future. url: https://doi.org/10.1016/j.cytogfr.2020.05.001 doi: 10.1016/j.cytogfr.2020.05.001 id: cord-025157-7b3v5yct author: Darreau, C. title: Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study date: 2020-05-24 words: 3615.0 sentences: 206.0 pages: flesch: 41.0 cache: ./cache/cord-025157-7b3v5yct.txt txt: ./txt/cord-025157-7b3v5yct.txt summary: In the multivariate analysis, seven parameters were significantly associated with early intubation and ranked as follows by decreasing weight: Glasgow score, center effect, use of accessory respiratory muscles, lactate level, vasopressor dose, pH and inability to clear tracheal secretions. Several arguments have been put forward in favor of early ventilatory support in septic shock patients, as part of the bundle that should be introduced in the first hours Open Access *Correspondence: nicolas.lerolle@univ-angers.fr 31 Medical Intensive Care Unit, Angers University Hospital, Angers, France Full list of author information is available at the end of the article of care together with antibiotic, fluid, and vasopressor use. To assess use, timing and factors associated with tracheal intubation in septic shock patients, we conducted a multicenter observational prospective study in 30 intensive care units (ICUs) in France and Spain. abstract: BACKGROUND: No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock. PATIENTS AND METHODS: This prospective multicenter observational study was conducted in 30 ICUs in France and Spain. All consecutive patients presenting with septic shock were eligible. The use of tracheal intubation was described across the participating ICUs. A multivariate analysis was performed to identify parameters associated with early intubation (before H8 following vasopressor onset). RESULTS: Eight hundred and fifty-nine patients were enrolled. Two hundred and nine patients were intubated early (24%, range 4.5–47%), across the 18 centers with at least 20 patients included. The cumulative intubation rate during the ICU stay was 324/859 (38%, range 14–65%). In the multivariate analysis, seven parameters were significantly associated with early intubation and ranked as follows by decreasing weight: Glasgow score, center effect, use of accessory respiratory muscles, lactate level, vasopressor dose, pH and inability to clear tracheal secretions. Global R-square of the model was only 60% indicating that 40% of the variability of the intubation process was related to other parameters than those entered in this analysis. CONCLUSION: Neurological, respiratory and hemodynamic parameters only partially explained the use of tracheal intubation in septic shock patients. Center effect was important. Finally, a vast part of the variability of intubation remained unexplained by patient characteristics. Trial registration Clinical trials NCT02780466, registered on May 23, 2016. https://clinicaltrials.gov/ct2/show/NCT02780466?term=intubatic&draw=2&rank=1. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245631/ doi: 10.1186/s13613-020-00668-6 id: cord-336201-fl606l3b author: Daryabor, Gholamreza title: The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System date: 2020-07-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro- and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases. url: https://www.ncbi.nlm.nih.gov/pubmed/32793223/ doi: 10.3389/fimmu.2020.01582 id: cord-313118-dv5xq2k4 author: Davis, Eric M. title: Neurologic Manifestations of Systemic Disease: Sleep Disorders date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: Sleep is intimately involved in overall health and wellbeing. We provide a comprehensive report on the interplay between systemic diseases and sleep to optimize the outcomes of systemic disorders. RECENT FINDINGS: Spanning the categories of endocrinologic disorders, metabolic/toxic disturbances, renal, cardiovascular, pulmonary, gastrointestinal, infectious diseases, autoimmune disorders, malignancy, and critical illness, the review highlights the prevalent coexisting pathology of sleep across the spectrum of systemic disorders. Although it is rare that treating a sleep symptom can cure disease, attention to sleep may improve quality of life and may mitigate or improve the underlying disorder. Recent controversies in assessing the cardiovascular relationship with sleep have called into question some of the benefits of treating comorbid sleep disorders, thereby highlighting the need for an ongoing rigorous investigation into how sleep interplays with systemic diseases. SUMMARY: Systemic diseases often have sleep manifestations and this report will help the clinician identify key risk factors linking sleep disorders to systemic diseases so as to optimize the overall care of the patient. url: https://doi.org/10.1007/s11940-020-00639-z doi: 10.1007/s11940-020-00639-z id: cord-347091-wbjpa5st author: Davis, Matthew R. title: That Escalated Quickly: Remdesivir's Place in Therapy for COVID-19 date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Remdesivir is a nucleoside antiviral recently studied in several randomized trials for treatment of COVID-19. The available observational and prospective data are conflicting, requiring clinicians to critically evaluate and reconcile results to determine patient populations that may optimally benefit from remdesivir therapy, especially while drug supply is scarce. In this review, we analyze pertinent clinical remdesivir data for patients with COVID-19 from January 1, 2020, through May 31, 2020. url: https://www.ncbi.nlm.nih.gov/pubmed/32651941/ doi: 10.1007/s40121-020-00318-1 id: cord-010933-xuztu95a author: Davis, Samuel title: Theoretical bounds and approximation of the probability mass function of future hospital bed demand date: 2018-11-06 words: 5975.0 sentences: 271.0 pages: flesch: 48.0 cache: ./cache/cord-010933-xuztu95a.txt txt: ./txt/cord-010933-xuztu95a.txt summary: Uncertainty in patient resource demand is caused by several stochastic processes, including the number and timing of arrivals and discharges, length of stay (LOS), unit transfers, health improvement and deterioration, surgical complications, and same-day cancellations for outpatient and surgical appointments. Developing and applying an accurate model to forecast patient resource demand for multiple time periods into the future improves both the cost and safety of providing care when coupled with an adaptive staffing strategy. Most models make simplifying assumptions to manage tractability and fit data availability, including assuming stationary or cyclic demand patterns [16, 17, 36] , exponential-based inter-arrival times and LOS distributions [17, 36, 48, 49] , patient homogeneity [10, 31, 36] , singleday forecasts [47] , and point estimates instead of probability mass functions (PMFs) [14, 31] . The goal of this study is to forecast an accurate approximation for the multi-period PMF of bed demand using the exact surgical schedule at the time of the forecast, non-stationary inter-arrival times, and patient-level duration-varying LOS distributions. abstract: Failing to match the supply of resources to the demand for resources in a hospital can cause non-clinical transfers, diversions, safety risks, and expensive under-utilized resource capacity. Forecasting bed demand helps achieve appropriate safety standards and cost management by proactively adjusting staffing levels and patient flow protocols. This paper defines the theoretical bounds on optimal bed demand prediction accuracy and develops a flexible statistical model to approximate the probability mass function of future bed demand. A case study validates the model using blinded data from a mid-sized Massachusetts community hospital. This approach expands upon similar work by forecasting multiple days in advance instead of a single day, providing a probability mass function of demand instead of a point estimate, using the exact surgery schedule instead of assuming a cyclic schedule, and using patient-level duration-varying length-of-stay distributions instead of assuming patient homogeneity and exponential length of stay distributions. The primary results of this work are an accurate and lengthy forecast, which provides managers better information and more time to optimize short-term staffing adaptations to stochastic bed demand, and a derivation of the minimum mean absolute error of an ideal forecast. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223092/ doi: 10.1007/s10729-018-9461-7 id: cord-305959-x061q8t7 author: Davoudi-Monfared, Effat title: A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19 date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: To the best of our knowledge, there is no published study on the use of interferon β-1a (IFN β-1a) in the treatment of severe COVID-19. In this randomized clinical trial, the efficacy and safety of IFN β-1a were evaluated in patients with severe COVID-19. Forty-two patients in the interferon group received IFN β-1a in addition to the national protocol medications (hydroxychloroquine plus lopinavir-ritonavir or atazanavir-ritonavir). Each 44-μg/ml (12 million IU/ml) dose of interferon β-1a was subcutaneously injected three times weekly for two consecutive weeks. The control group consisted of 39 patients who received only the national protocol medications. The primary outcome of the study was time to reach clinical response. Secondary outcomes were duration of hospital stay, length of intensive care unit stay, 28-day mortality, effect of early or late administration of IFN on mortality, adverse effects, and complications during the hospitalization. Between 29 February and 3 April 2020, 92 patients were recruited, and a total of 42 patients in the IFN group and 39 patients in the control group completed the study. As the primary outcome, time to the clinical response was not significantly different between the IFN and the control groups (9.7 ± 5.8 versus 8.3 ± 4.9 days, respectively, P = 0.95). On day 14, 66.7% versus 43.6% of patients in the IFN group and the control group, respectively, were discharged (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.05 to 6.37). The 28-day overall mortality was significantly lower in the IFN than the control group (19% versus 43.6%, respectively, P = 0.015). Early administration significantly reduced mortality (OR, 13.5; 95% CI, 1.5 to 118). Although IFN did not change the time to reach the clinical response, adding it to the national protocol significantly increased discharge rate on day 14 and decreased 28-day mortality. (This study is in the Iranian Registry of Clinical Trials under identifier IRCT20100228003449N28.) url: https://doi.org/10.1128/aac.01061-20 doi: 10.1128/aac.01061-20 id: cord-013457-rqon1adg author: De Cannière, Hélène title: Short-Term Exercise Progression of Cardiovascular Patients throughout Cardiac Rehabilitation: An Observational Study date: 2020-09-29 words: 7360.0 sentences: 399.0 pages: flesch: 45.0 cache: ./cache/cord-013457-rqon1adg.txt txt: ./txt/cord-013457-rqon1adg.txt summary: The goal of the study was to obtain a better understanding of the short-term progression of functional capacity throughout multidisciplinary CR, measured as the change in walking distance between baseline six-minute walking test (6MWT) and four consecutive follow-up tests. Although the majority of studies on home-and center-based CR programs report data on changes in exercise capacity measured at baseline and on completion of the intervention limited information is available on the short-term progression in exercise capacity throughout the CR [20] [21] [22] . A one-way repeated measures ANOVA was conducted to determine whether there were statistically significant differences in mean 6MWT distance (6MWD) over the period of a three-month rehabilitation program. Future studies should investigate whether similar progression patterns emerge in both center-based (including with larger patient groups) and in home-based CR programs and whether this short-term information on progression can be used to optimize outcomes by improving exercise capacity and motivation. abstract: Cardiac rehabilitation (CR) is a highly recommended secondary prevention measure for patients with diagnosed cardiovascular disease. Unfortunately, participation rates are low due to enrollment and adherence issues. As such, new CR delivery strategies are of interest, as to improve overall CR delivery. The goal of the study was to obtain a better understanding of the short-term progression of functional capacity throughout multidisciplinary CR, measured as the change in walking distance between baseline six-minute walking test (6MWT) and four consecutive follow-up tests. One-hundred-and-twenty-nine patients diagnosed with cardiovascular disease participated in the study, of which 89 patients who completed the whole study protocol were included in the statistical analysis. A one-way repeated measures ANOVA was conducted to determine whether there was a significant change in mean 6MWT distance (6MWD) throughout CR. A three-way-mixed ANOVA was performed to determine the influence of categorical variables on the progression in 6MWD between groups. Significant differences in mean 6MWD between consecutive measurements were observed. Two subgroups were identified based on the change in distance between baseline and end-of-study. Patients who increased most showed a linear progression. In the other group progression leveled off halfway through rehabilitation. Moreover, the improvement during the initial phase of CR seemed to be indicative for overall progression. The current study adds to the understanding of the short-term progression in exercise capacity of patients diagnosed with cardiovascular disease throughout a CR program. The results are not only of interest for CR in general, but could be particularly relevant in the setting of home-based CR. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601310/ doi: 10.3390/jcm9103160 id: cord-297532-ktiwfcop author: De Fata Salvatores, Gaia title: Patients with bullous disorders during COVID‐19 period: management and adherence to treatment date: 2020-05-26 words: 558.0 sentences: 34.0 pages: flesch: 44.0 cache: ./cache/cord-297532-ktiwfcop.txt txt: ./txt/cord-297532-ktiwfcop.txt summary: SARS-CoV2 infection has now spread all over the world and higher mortality rates have been reported among elderly and comorbid (diabetes, cardiovascular disease, immunosuppression) patients. We want to share our experience about the management of patients with bullous disorders, in particular pemphigoid disease in our outpatient clinic during COVID-19 pandemic. 10 patients (6 women and 4 men) with a median age of 68.5 years, affected by bullous pemphigoid, all histologically confirmed, were already followed in our Day-Hospital service before the COVID-19 pandemic spread. Weekly telephonic consultations were performed in order to control patients adherence to treatment and to avoid the risk of COVID-19 infection. In literature, several articles suggesting the use of teledermatology services, such as video-call visits, e-mail and mobile applications as useful tool to take care of patients during this pandemic period have already been abstract: nan url: https://doi.org/10.1111/dth.13697 doi: 10.1111/dth.13697 id: cord-265812-1hcp36cw author: De Jong, Cornelis N. title: Etanercept for steroid-refractory acute graft-versus-host disease: A single center experience date: 2017-10-26 words: 3168.0 sentences: 186.0 pages: flesch: 53.0 cache: ./cache/cord-265812-1hcp36cw.txt txt: ./txt/cord-265812-1hcp36cw.txt summary: W.; Van der Klift, Marjolein; Cornelissen, Jan J.; Broers, Annoek E. High dose glucocorticosteroids, are currently recommended as first-line treatment for grade II-IV aGVHD resulting in overall complete responses (CR) in 40%-50% of patients. CONCLUSION: Second-line treatment with etanercept does induce responses in SR-aGVHD of the gut but appears to be associated with poor long-term survival even in responding patients. High dose systemic glucocorticosteroids (steroids) are currently recommended as first-line treatment for grade II-IV aGVHD resulting in overall complete responses (CR) in 40%-50% of patients [2, 3] . Studies evaluating second-line treatment with the anti-TFNα agent etanercept have shown promising results with overall response rates of 50-80% [8] [9] [10] . In conclusion, although second-line treatment of SR-aGVHD of the gut with etanercept was associated with a promising initial response rate, overall survival appeared very poor, mainly due to progression of GVHD and opportunistic infections. abstract: BACKGROUND: Acute graft-versus-host disease (aGVHD) is an important complication of allogeneic stem cell transplantation (alloSCT). High dose glucocorticosteroids, are currently recommended as first-line treatment for grade II-IV aGVHD resulting in overall complete responses (CR) in 40%-50% of patients. No standard second-line regimen has been established. Different options have been reported, including anti-TNFα antibodies. METHODS: We retrospectively reviewed the outcome of 15 patients with steroid-refractory (SR) aGVHD treated with etanercept at our institution. Patients were transplanted for a hematological malignancy and received either a myeloablative or a non-myeloablative conditioning regimen. Prophylaxis of GVHD consisted of cyclosporin A and mycophenolic acid. RESULTS: Acute GVHD was diagnosed at a median of 61 days post-transplantation. All patients had grade III aGVHD of the gut. Second-line treatment with etanercept was started at a median of 13 days after initiation of first-line therapy. Overall response rate was 53%, with CR in 3 patients and PR in 5 patients. Median overall survival after initiation of treatment with etanercept was 66 days (range 5–267) for the entire group. Median overall survival was 99 days (range 47–267 days) for responders and 17 days (range 5–66 days) for non-responders (p<0.01). Nevertheless, all patients died. Causes of death were progressive GVHD in 7 patients (47%), infection in 6 patients (40%), cardiac death in 1 patient (6.7%) and relapse in 1 patient (6,7%). CONCLUSION: Second-line treatment with etanercept does induce responses in SR-aGVHD of the gut but appears to be associated with poor long-term survival even in responding patients. url: https://www.ncbi.nlm.nih.gov/pubmed/29073260/ doi: 10.1371/journal.pone.0187184 id: cord-269690-6r2bfydw author: De Lorenzo, Rebecca title: Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study date: 2020-10-14 words: 4421.0 sentences: 245.0 pages: flesch: 44.0 cache: ./cache/cord-269690-6r2bfydw.txt txt: ./txt/cord-269690-6r2bfydw.txt summary: Primary outcome was need of follow-up, defined as the presence at follow-up of at least one among: respiratory rate (RR) >20 breaths/min, uncontrolled blood pressure (BP) requiring therapeutic change, moderate to very severe dyspnoea, malnutrition, or new-onset cognitive impairment, according to validated scores. At regression tree analysis, the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO(2)/FiO(2)) and body mass index (BMI) at ED presentation, and age emerged as independent predictors of the need of follow-up. Demographical data (i.e. age, gender, and ethnicity), comorbidities (i.e. hypertension, HTN, coronary artery disease, CAD, diabetes mellitus, DM, chronic obstructive pulmonary disease, COPD, chronic kidney disease, CKD, active cancer, and current psychiatric disorder according to DSM-5), as well as body mass index (BMI), axillary body temperature, and laboratory values (i.e. the ratio of arterial oxygen partial pressure, PaO 2 in mmHg, to fractional inspired oxygen, FiO 2 , expressed as a fraction, PaO 2 /FiO 2 , white blood cell count, WBC, neutrophil to lymphocyte ratio, NLR, liver enzymes, lactate dehydrogenase, LDH, C-reactive protein, CRP, estimated glomerular filtration rate, eGFR using the CKD-EPI equation) at ED presentation were extracted for all patients. abstract: Data on residual clinical damage after Coronavirus disease-2019 (COVID-19) are lacking. The aims of this study were to investigate whether COVID-19 leaves behind residual dysfunction, and identify patients who might benefit from post-discharge monitoring. All patients aged ≥18 years admitted to the Emergency Department (ED) for COVID-19, and evaluated at post-discharge follow-up between 7 April and 7 May, 2020, were enrolled. Primary outcome was need of follow-up, defined as the presence at follow-up of at least one among: respiratory rate (RR) >20 breaths/min, uncontrolled blood pressure (BP) requiring therapeutic change, moderate to very severe dyspnoea, malnutrition, or new-onset cognitive impairment, according to validated scores. Post-traumatic stress disorder (PTSD) served as secondary outcome. 185 patients were included. Median [interquartile range] time from hospital discharge to follow-up was 23 [20–29] days. 109 (58.9%) patients needed follow-up. At follow-up evaluation, 58 (31.3%) patients were dyspnoeic, 41 (22.2%) tachypnoeic, 10 (5.4%) malnourished, 106 (57.3%) at risk for malnutrition. Forty (21.6%) patients had uncontrolled BP requiring therapeutic change, and 47 (25.4%) new-onset cognitive impairment. PTSD was observed in 41 (22.2%) patients. At regression tree analysis, the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO(2)/FiO(2)) and body mass index (BMI) at ED presentation, and age emerged as independent predictors of the need of follow-up. Patients with PaO(2)/FiO(2) <324 and BMI ≥33 Kg/m(2) had the highest odds to require follow-up. Among hospitalised patients, age ≥63 years, or age <63 plus non-invasive ventilation or diabetes identified those with the highest probability to need follow-up. PTSD was independently predicted by female gender and hospitalisation, the latter being protective (odds ratio, OR, 4.03, 95% confidence interval, CI, 1.76 to 9.47, p 0.0011; OR 0.37, 95% CI 0.14 to 0.92, p 0.033, respectively). COVID-19 leaves behind physical and psychological dysfunctions. Follow-up programmes should be implemented for selected patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33052920/ doi: 10.1371/journal.pone.0239570 id: cord-289828-3k088z9n author: De Salvo, Andrea title: How to be together and carry on our project activities during COVID‐19 pandemic in Rome date: 2020-08-03 words: 1052.0 sentences: 58.0 pages: flesch: 59.0 cache: ./cache/cord-289828-3k088z9n.txt txt: ./txt/cord-289828-3k088z9n.txt summary: [3] [4] [5] In the last few years, numerous initiatives and dedicated programs were developed worldwide with the aim to help these patients to deal with diagnosis and treatments, and also to allow them to imagine, dream, design, learn, and maintain relationships with their peers in and outside the hospital walls. AYA with cancer are more vulnerable to experience high levels of fear and Play4You gave them a coping strategy based on game sharing. The aim of this report was to share with the community that takes care of AYAs; this model is able to reach and help more patients at home, in hospital or elsewhere, simply by using relatively old tools such as Internet connection, individuals'' smartphones, and selected RPGs. Psychosocial dimensions of cancer in adolescents and young adults The experience of loneliness among young adult cancer patients Health and supportive care needs of young adult cancer patients and survivors abstract: nan url: https://doi.org/10.1002/pbc.28431 doi: 10.1002/pbc.28431 id: cord-332150-j76726no author: De Stefano, Ludovico title: A “Window of Therapeutic Opportunity” for Anti-Cytokine Therapy in Patients With Coronavirus Disease 2019 date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The effects of cytokine inhibition in the different phases of the severe coronavirus disease 2019 (COVID-19) are currently at the center of intense debate, and preliminary results from observational studies and case reports offer conflicting results thus far. The identification of the correct timing of administration of anti-cytokine therapies and other immunosuppressants in COVID-19 should take into account the intricate relationship between the viral burden, the hyperactivation of the innate immune system and the adaptive immune dysfunction. The main challenge for effective administration of anti-cytokine therapy in COVID-19 will be therefore to better define a precise “window of therapeutic opportunity.” Only considering a more specific set of criteria able to integrate information on direct viral damage, the cytokine burden, and the patient’s immune vulnerability, it will be possible to decide, carefully balancing both benefits and risks, the appropriateness of using immunosuppressive drugs even in patients affected primarily by an infectious disease. url: https://doi.org/10.3389/fimmu.2020.572635 doi: 10.3389/fimmu.2020.572635 id: cord-332055-lrpfzsog author: DeVos, Elizabeth title: Approach to Adult Patients with Acute Dyspnea date: 2015-11-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Undifferentiated patients in respiratory distress require immediate attention in the emergency department. Using a thorough history and clinical examination, clinicians can determine the most likely causes of dyspnea. Understanding the pathophysiology of the most common diseases contributing to dyspnea guides rational testing and informed, expedited treatment decisions. url: https://www.sciencedirect.com/science/article/pii/S0733862715000747 doi: 10.1016/j.emc.2015.08.008 id: cord-283517-7gd0f06m author: Deak, Eszter title: Right-Sizing Technology in the Era of Consumer-Driven Health Care date: 2017-08-01 words: 6857.0 sentences: 331.0 pages: flesch: 45.0 cache: ./cache/cord-283517-7gd0f06m.txt txt: ./txt/cord-283517-7gd0f06m.txt summary: Today, we have molecular point-ofcare (mPOC) devices that can provide a rapid diagnostic answer within 20 minutes in a clinic, multiplex PCR sample-to-answer devices that can screen for >20 analytes in a single specimen in about an hour, high-volume automation that can enhance throughput and efficiency in the clinical microbiology laboratory with digital imaging, and next-generation sequencing (NGS) that can reveal a treasure trove of information in a single test. Factors may include syndrome-specific diagnostic needs, ease of use, the need for rapid results, improved sensitivity and specificity, operational needs (such as staffing and expertise), laboratory design (such as centralized versus decentralized models), cost, consumer demand, and the potential for improved patient outcomes. Considerations that go into the selection of a test or instrument platform for implementation include perceived turnaround time needs for improved patient care, sample volume requirements, number of tests expected, suitability for the intended laboratory based on available expertise and desired workflow, as well as cost. abstract: Abstract Technology for modern clinical and public health microbiology laboratories has evolved at an impressive rate over the last two decades. Contemporary diagnostics can rapidly provide powerful data that can impact patient lives and support infectious disease outbreak investigations. At the same time, dramatic changes to health care delivery are putting new pressures on a system that is now focusing on patient-centric, value-driven, convenient care. For laboratories, balancing all these demands in a cost-contained environment remains a challenge. This article explores the current and future directions of diagnostics in our dynamic health care environment. url: https://www.sciencedirect.com/science/article/pii/S0196439917300491 doi: 10.1016/j.clinmicnews.2017.07.001 id: cord-012560-p5s0p7fd author: Decavèle, Maxens title: One-year survival of patients with high-grade glioma discharged alive from the intensive care unit date: 2020-08-29 words: 3703.0 sentences: 178.0 pages: flesch: 43.0 cache: ./cache/cord-012560-p5s0p7fd.txt txt: ./txt/cord-012560-p5s0p7fd.txt summary: We sought to quantify 1-year mortality and evaluate the association between mortality and (1) functional status, and (2) management of anticancer therapy in patients with high-grade glioma discharged alive from the intensive care unit. On multivariate logistic regression analysis, two factors were independently associated with lower mortality 1 year after ICU admission: continuation of anticancer therapy after ICU discharge (OR 0.18, 95% CI 0.03-0.75, p = 0.028), and Karnofsky performance status at ICU admission (OR 0.90, 95% CI 0.85-0.95, p < 0.001). The main results of the study can be summarized as follows: in HGG patients discharged alive after an unplanned medical ICU stay (1), we observed a substantial proportion of survivors 1 year after ICU admission (more than one quarter of patients) and most of these patients exhibited relatively favorable performance status even 1 year after ICU admission, (2) continuation of anticancer therapy was possible in almost 50% of patients and was strongly associated with cancer progression and use of corticosteroids at admission, and (3) continuation of anticancer therapy and Karnofsky performance status at admission were associated with higher 1-year survival rates. abstract: INTRODUCTION: Only limited data are available regarding the long-term prognosis of patients with high-grade glioma discharged alive from the intensive care unit. We sought to quantify 1-year mortality and evaluate the association between mortality and (1) functional status, and (2) management of anticancer therapy in patients with high-grade glioma discharged alive from the intensive care unit. PATIENTS AND METHODS: Retrospective observational cohort study of patients with high-grade glioma admitted to two intensive care units between January 2009 and June 2018. Functional status was assessed by the Karnofsky Performance Status. Anticancer therapy after discharge was classified as (1) continued (unchanged), (2) modified (changed or stopped), or (3) initiated (for newly diagnosed disease). RESULTS: Ninety-one high-grade glioma patients (73% of whom had glioblastoma) were included and 78 (86%) of these patients were discharged alive from the intensive care unit. Anticancer therapy was continued, modified, and initiated in 41%, 42%, and 17% of patients, respectively. Corticosteroid therapy at the time of ICU admission [odds ratio (OR) 0.07] and cancer progression (OR 0.09) was independently associated with continuation of anticancer therapy. The mortality rate 1 year after ICU admission was 73%. On multivariate analysis, continuation of anticancer therapy (OR 0.18) and Karnofsky performance status on admission (OR 0.90) were independently associated with lower 1-year mortality. CONCLUSION: The presence of high-grade glioma is not sufficient to justify refusal of intensive care unit admission. Performance status and continuation of anticancer therapy are associated with higher survival after intensive care unit discharge. PREVIOUS PRESENTATION: Preliminary results were presented at the most recent congress of the French Intensive Care Society, Paris, 2019. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00415-020-10191-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456207/ doi: 10.1007/s00415-020-10191-0 id: cord-270654-cz2y6ta9 author: Deftereos, Spyridon G. title: The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design date: 2020-04-03 words: 2114.0 sentences: 136.0 pages: flesch: 43.0 cache: ./cache/cord-270654-cz2y6ta9.txt txt: ./txt/cord-270654-cz2y6ta9.txt summary: Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. Based on the aforementioned data, the question which arises is whether colchicine, administered in a relatively low dose, could potentially have an effect the patients'' clinical course by limiting the myocardial necrosis and pneumonia development in the context of COVID-19. Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation abstract: OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. METHODS: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group. RESULTS: Trial results will be disseminated through peer-reviewed publications and conference presentations. CONCLUSION: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790). url: https://api.elsevier.com/content/article/pii/S1109966620300610 doi: 10.1016/j.hjc.2020.03.002 id: cord-006714-q7wy76e2 author: Delannoy, P.-Y. title: Impact of combination therapy with aminoglycosides on the outcome of ICU-acquired bacteraemias date: 2012-02-15 words: 2878.0 sentences: 173.0 pages: flesch: 43.0 cache: ./cache/cord-006714-q7wy76e2.txt txt: ./txt/cord-006714-q7wy76e2.txt summary: Our study supports the hypothesis that combination short-term antibiotherapy with an aminoglycoside for ICU-acquired bacteraemias could increase survival. Meta-analysis failed to demonstrate improved outcomes in patients treated with antibiotic combinations over those receiving monotherapy [1] [2] [3] [4] and resulted in a decreased use of combination therapy. We performed a retrospective study to evaluate the impact of AGs in antimicrobial combination on ICU-acquired bacteraemia in our universityaffiliated ICU [8] [9] [10] [11] . The aim of the study was to evaluate the impact of AGs in antibiotic combination on the outcome of patients with ICU-acquired bacteraemia. We found a survival benefit with the use of combination therapy with AGs for ICU-acquired bacteraemias. In the ICU, inadequate empirical antibiotic therapy is associated with an increased mortality risk in patients with ventilator-associated pneumonia and bacteraemia. Our study suggests that short-term combination beta-lactams plus AGs therapy in intensive care unit (ICU)-acquired bacteraemia could reduce mortality. abstract: Pharmacodynamic studies report on the rapid bactericidal activity of aminoglycosides, conferring them as being of theoretical interest for bacteraemia treatment. We assessed this issue in a retrospective study of patients with intensive care unit (ICU)-acquired bacteraemias. To determine the impact of aminoglycosides in antimicrobial combination on the outcome of patients with bacteraemia, we performed a monovariate analysis and a logistic regression analysis comparing patients treated with or without aminoglycosides. Forty-eight bacteraemias in 48 patients were included. Eighteen patients received aminoglycosides. Baseline characteristics as well as adaptation and adequation of antibiotherapy did not differ in patients who did or did not receive aminoglycosides. Patients who received aminoglycosides had longer time alive away from the ICU (11.3 ± 8.9 (10 [0–20]) vs. 3.2 ± 6.6 (0 [0–2] days; p = 0.002) and free from mechanical ventilation (12.5 ± 9.3 (14 [0–21] vs. 5.5 ± 9.2 (0 [0–10] days; p = 0.02) on day 28. The ICU mortality was 16% in the aminoglycoside group versus 46% (p = 0.03). In the multivariate analysis, patients treated with aminoglycosides were 6 times less likely to die than those treated without aminoglycosides (confidence interval [CI] = [1.3–28.9]; p = 0.02). Our study supports the hypothesis that combination short-term antibiotherapy with an aminoglycoside for ICU-acquired bacteraemias could increase survival. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102278/ doi: 10.1007/s10096-012-1568-z id: cord-277576-3dvt6uj7 author: Demir, Erol title: COVID‐19 in kidney transplant recipients: A multicenter experience in Istanbul date: 2020-07-13 words: 2243.0 sentences: 169.0 pages: flesch: 51.0 cache: ./cache/cord-277576-3dvt6uj7.txt txt: ./txt/cord-277576-3dvt6uj7.txt summary: INTRODUCTION: Management of COVID‐19 in kidney transplant recipients should include treatment of the infection, regulation of immunosuppression, and supportive therapy. MATERIAL AND METHODS: Kidney transplant recipients diagnosed with COVID‐19 from five major transplant centers in Istanbul, Turkey, were included in this retrospective cohort study. [1] [2] [3] [4] [5] [6] [7] Although uremia and kidney transplantation are not considered a risk factor in COVID-19, SARS-CoV-2 often causes a moderate or severe infection in kidney transplant recipients. Kidney transplant recipients diagnosed with COVID-19 from five major transplant centers in Istanbul, Turkey, were included in this retrospective cohort study. 2, 4, 5 To the best of our knowledge, the use of favipiravir and anakinra in the treatment of COVID-19 in kidney transplant recipients has not been previously reported. In conclusion, COVID-19 has been seen to more commonly cause moderate or severe pneumonia in kidney transplant recipients, possibly due to immunosuppressive therapy. abstract: INTRODUCTION: Management of COVID‐19 in kidney transplant recipients should include treatment of the infection, regulation of immunosuppression, and supportive therapy. However, there is no consensus on this issue yet. This study aimed to our experiences with kidney transplant recipients diagnosed with COVID‐19. MATERIAL AND METHODS: Kidney transplant recipients diagnosed with COVID‐19 from five major transplant centers in Istanbul, Turkey, were included in this retrospective cohort study. Patients were classified as having moderate or severe pneumonia for the analysis. The primary endpoint was all‐cause mortality. The secondary endpoints were acute kidney injury, the average length of hospital stay, admission to intensive care, and mechanical ventilation. RESULTS: Forty patients were reviewed retrospectively over a follow‐up period of 32 days after being diagnosed with COVID‐19. Cough, fever, and dyspnea were the most frequent symptoms in all patients. The frequency of previous induction and rejection therapy was significantly higher in the group with severe pneumonia compared to the moderate pneumonia group. None of the patients using cyclosporine A developed severe pneumonia. Five patients died during follow‐up in the intensive care unit. None of the patients developed graft loss during follow‐up. DISCUSSION: COVID‐19 has been seen to more commonly cause moderate or severe pneumonia in kidney transplant recipients. Immunosuppression should be carefully reduced in these patients. Induction therapy with lymphocyte‐depleting agents should be carefully avoided in kidney transplant recipients during the pandemic period. url: https://doi.org/10.1111/tid.13371 doi: 10.1111/tid.13371 id: cord-300559-vuuxthx2 author: Deng, Ming title: Obesity as a Potential Predictor of Disease Severity in Young COVID‐19 Patients: A Retrospective Study date: 2020-06-29 words: 4164.0 sentences: 251.0 pages: flesch: 53.0 cache: ./cache/cord-300559-vuuxthx2.txt txt: ./txt/cord-300559-vuuxthx2.txt summary: Logistic regression analysis showed that male, high body mass index (especially obesity), elevated fasting blood glucose and urinary protein positive are all risk factors for severe young COVID‐19 patients. The analysis showed that a high body mass index (especially obesity), an elevated FBG level, an elevated LDH level, and urinary protein positivity were all risk factors for severe COVID-19 in these young patients. A recently published study from China also showed that in metabolic-associated fatty liver disease patients, obesity can increase the risk for severe COVID-19 by about 6-fold [22] . Notably, in the present study, all of the severely or critically ill COVID-19 patients were males, an observation which may also be related to the distribution of obesity in China. Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease abstract: OBJECTIVE: To explore the indicators for severity in young COVID‐19 patients age between 18 to 40. METHODS: This retrospective cohort study includes 65 consecutively admitted COVID‐19 patients age between 18 to 40 in Zhongnan Hospital of Wuhan University. Among them, 53 were moderate cases, 12 were severe or critical cases. Epidemiological, clinical and laboratory characteristics and treatment data were collected. A multivariate logistic regression analysis was implemented to explore risk factors. RESULTS: The severe/critical cases have obviously higher BMI (average 29.23 vs. 22.79kg/m(2)) and lower liver CT value (average 50.00 vs. 65.00mU) than moderate cases group. The severe/critical cases have higher fasting glucose, alanine aminotransferase (ALT) , aspartate aminotransferase (AST) , and creatinine (Cr) compared with moderate cases (All P<0.01) . More severe/critical cases (58.33% vs. 1.92%) have positive urine protein. The severe/critical cases will experience a significant process of serum albumin decline. Logistic regression analysis showed that male, high body mass index (especially obesity), elevated fasting blood glucose and urinary protein positive are all risk factors for severe young COVID‐19 patients. CONCLUSION: Obesity is an important predictor of severity in young COVID‐19 patients. The main mechanism is related to the damage of liver and kidney. url: https://doi.org/10.1002/oby.22943 doi: 10.1002/oby.22943 id: cord-015930-18qznqp0 author: Denstaedt, Scott J. title: Hemophagocytic Lymphohistiocytosis and Other Culture Negative Sepsis-Like Syndromes in the ICU date: 2019-07-24 words: 4494.0 sentences: 235.0 pages: flesch: 35.0 cache: ./cache/cord-015930-18qznqp0.txt txt: ./txt/cord-015930-18qznqp0.txt summary: Given his unremarkable bone marrow biopsy 7 days before and elevated fibrinogen, the possibility of hemophagocytic lymphohistiocytosis (HLH) was dismissed as his hyperferritinemia and elevated sIL-2R were attributed to history of blood transfusion and occult infection. A recent consensus review on malignancy-associated HLH suggests tailoring treatment to the underlying trigger, performance status, organ function and additional therapies the patient is receiving [12] . In critically ill adults, however, the increased prevalence of conditions which elevate ferritin, such as infection, malignancy, autoimmune disease, liver injury and chronic blood transfusion make hyperferritinemia a nonspecific finding for HLH [26, 27] . While effective in inducing bone marrow remission [43] [44] [45] , CAR-T cells may be associated with the development of cytokine release syndrome (CRS) which frequently requires treatment in the ICU. Several important clinical syndromes, including HLH, MAS, IPS, and CRS can mimic sepsis and cause critical illness through immune dysregulation in the absence of infection. abstract: There are many sepsis-like inflammatory syndromes that may be encountered by critical care practitioners. Clinically, these syndromes may imitate sepsis and are often identified after an extensive, but unrevealing evaluation for infection. In some instances, these syndromes are anticipated complications of advanced therapies for malignancy. It is vitally important to identify these disorders and treat them with specific chemotherapeutic or immunomodulating therapies. This chapter will focus on hemophagocytic lympho-histiocytosis (HLH), a rare disorder of pathologic immune system activation that presents as a sepsis-like illness in the critically ill. While treatment of HLH with chemotherapy and immunosuppression should be guided by an expert hematologist, the diagnosis is often made by the critical care medicine practitioner. We present a case illustrating the challenges of defining this syndrome in a patient with recurrent critical illness, and review the evidence underlying diagnostic and prognostic criteria for this protean syndrome. We also review several of the more common sepsis-like inflammatory syndromes that are encountered in the critical care unit along with their specific treatments. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120049/ doi: 10.1007/978-3-030-26710-0_79 id: cord-334075-ruqd2c1j author: Der Sarkissian, Samuel title: Response of a tertiary dermatology department to COVID‐19 date: 2020-04-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1111/ajd.13298 doi: 10.1111/ajd.13298 id: cord-027266-jdti1pwa author: Derevitskii, Ilya V. title: The Atrial Fibrillation Risk Score for Hyperthyroidism Patients date: 2020-05-23 words: 4049.0 sentences: 274.0 pages: flesch: 52.0 cache: ./cache/cord-027266-jdti1pwa.txt txt: ./txt/cord-027266-jdti1pwa.txt summary: In the first approach, the authors study risk factors for atrial fibrillation, predicting the probability of AF development for a specific period using regression analysis. Using the system for ranking we need to create an easy-to-use and interpretable model for assessing the risk of developing atrial fibrillation in patients with thyrotoxicosis. The main objective of the study is to create a practical method for assessing the risk of developing atrial fibrillation in a patient with thyrotoxicosis. The age and heart rate detected at the first examination also increase the probability of atrial fibrillation in patients with thyrotoxicosis and supraventricular extrasystole. This decision tree is a fairly simple and well-interpreted method that can be useful as part of a support and decision-making system for medical professionals working with patients The Atrial Fibrillation Risk Score for Hyperthyroidism Patients with thyrotoxicosis. abstract: Thyrotoxicosis (TT) is associated with an increase in both total and cardiovascular mortality. One of the main thyrotoxicosis complications is Atrial Fibrillation (AF). Right AF predictors help medical personal prescribe the select patients with high risk of TAF for a closest follow-up or for an early radical treatment of thyrotoxicosis. The main goal of this study is creating a method for practical treatment and diagnostic AF. This study proposes a new method for assessing the risk of occurrence atrial fibrillation for patients with TT. This method considers both the features of the complication and the specifics of the chronic disease. A model is created based on case histories of patients with thyrotoxicosis. We used Machine Learning methods for creating several models. Each model has advantages and disadvantages depending on the diagnostic and medical purposes. The resulting models show high results in the different metrics of the prediction of a thyrotoxic AF. These models are interpreted and simple for use. Therefore, models can be used as part of the support and decision-making system (DSS) by medical specialists in the treatment AF. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303683/ doi: 10.1007/978-3-030-50423-6_37 id: cord-287957-diyz54qy author: Deriba, Berhanu Senbeta title: Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities date: 2020-10-13 words: 4256.0 sentences: 226.0 pages: flesch: 45.0 cache: ./cache/cord-287957-diyz54qy.txt txt: ./txt/cord-287957-diyz54qy.txt summary: title: Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities Therefore, this study aimed to assess patient satisfaction and associated factors among chronic patients who had a follow-up in North Shoa healthcare facilities. Therefore, this study aimed to assess patient satisfaction and associated factors during the COVID-19 pandemic among chronic patients who had follow-up at public health facilities in the North Shoa Zone, Oromia region, Ethiopia. Patients who maintained and observed better social distancing at the registration place, waiting for the outpatient department, laboratory, and pharmacy services as a means of the COVID-19 prevention in the healthcare facilities were significantly associated with patient satisfaction. Availability of sign and direction indicators, availability of ordering drugs, social distancing status in the healthcare facility, availability of alcohol, and sanitizer for hand cleaning at the healthcare facility entrance to prevent and control COVID-19 were factors associated with the satisfaction of patients with chronic diseases. abstract: BACKGROUND: Patient satisfaction is an indicator of healthcare quality service and involved as an outcome measure. Quality of healthcare service and patient satisfaction has been affected by the current coronavirus disease 2019 (COVID-19) pandemic. It induced uncertainness and shortage of medical supplies due to a limited global movement. Therefore, this study aimed to assess patient satisfaction and associated factors among chronic patients who had a follow-up in North Shoa healthcare facilities. METHODS: An institutional-based cross-sectional study was used to select 410 study participants through a systematic random sampling technique. Data were collected by a structured interviewer-administered questionnaire, entered into Epi Info version 7, and transported to SPSS version 23 for analysis. Bivariable and multivariable logistic regressions were used to identify the factors associated with satisfaction. The odds ratio with a 95% confidence interval was computed, and p-value <0.05 was considered statistical significance in the multivariable model. RESULTS: The overall level of patient satisfaction was 44.6%. The presence of sign and direction indicators (AOR=3.26, 95% CI=1.1, 9.92), obtaining some ordered drugs (AOR=3.7, 95% CI=1.1, 12.54), getting alcohol for hand cleaning (AOR=2.66, 95% CI=1.1,6.65), obtaining sanitizer for hand cleaning (AOR=4.45, 95% CI=1.72,11.52), and maintaining social distancing (AOR=2.63, 95% CI=1.21, 5.70) were factors associated with patient’s satisfaction. CONCLUSION: The level of patient satisfaction was very low during a COVID-19 pandemic. The presence of sign and direction indicators, availability of drugs, social distancing, availability of alcohol, and sanitizer were factors associated with patient satisfaction. The intervention targeted at increasing patient satisfaction and improving the quality of service during COVID-19 through maintaining social distancing and availing alcohol or sanitizers is necessary. url: https://www.ncbi.nlm.nih.gov/pubmed/33116436/ doi: 10.2147/ppa.s276254 id: cord-334367-w96iqo6q author: Devlin, John W. title: Strategies to Optimize ICU Liberation (A to F) Bundle Performance in Critically Ill Adults With Coronavirus Disease 2019 date: 2020-06-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The severe acute respiratory syndrome coronavirus 2 pandemic has stretched ICU resources in an unprecedented fashion and outstripped personal protective equipment supplies. The combination of a novel disease, resource limitations, and risks to medical personnel health have created new barriers to implementing the ICU Liberation (“A” for Assessment, Prevention, and Manage pain; “B” for Both Spontaneous Awakening Trials and Spontaneous Breathing Trials; “C” for Choice of Analgesia and Sedation; “D” for Delirium Assess, Prevent, and Manage; “E” for Early Mobility and Exercise; and “F” for Family Engagement and Empowerment [ABCDEF]) Bundle, a proven ICU care approach that reduces delirium, shortens mechanical ventilation duration, prevents post-ICU syndrome, and reduces healthcare costs. This narrative review acknowledges barriers and offers strategies to optimize Bundle performance in coronavirus disease 2019 patients requiring mechanical ventilation. DATA SOURCES, STUDY SELECTION, AND DATA EXTRACTION: The most relevant literature, media reports, and author experiences were assessed for inclusion in this narrative review including PubMed, national newspapers, and critical care/pharmacology textbooks. DATA SYNTHESIS: Uncertainty regarding coronavirus disease 2019 clinical course, shifts in attitude, and changes in routine behavior have hindered Bundle use. A domino effect results from: 1) changes to critical care hierarchy, priorities, and ICU team composition; 2) significant personal protective equipment shortages cause; 3) reduced/restricted physical bedside presence favoring; 4) increased depth of sedation and use of neuromuscular blockade; 5) which exacerbate drug shortages; and 6) which require prolonged use of limited ventilator resources. Other identified barriers include manageable knowledge deficits among non-ICU clinicians unfamiliar with the Bundle or among PICU specialists deploying pediatric-based Bundle approaches who are unfamiliar with adult medicine. Both groups have been enlisted to augment the adult ICU work force to meet demand. Strategies were identified to facilitate Bundle performance to liberate patients from the ICU. CONCLUSIONS: We acknowledge current challenges that interfere with comprehensive management of critically ill patients during the coronavirus disease 2019 pandemic. Rapid response to new circumstances precisely requires established safety mechanisms and protocols like the ABCDEF Bundle to increase ICU and ventilator capacity and help survivors maximize recovery from coronavirus disease 2019 as early as possible. url: https://www.ncbi.nlm.nih.gov/pubmed/32696002/ doi: 10.1097/cce.0000000000000139 id: cord-260215-gsnjlhjd author: Dhanani, Jayesh title: Fundamentals of aerosol therapy in critical care date: 2016-10-07 words: 8319.0 sentences: 485.0 pages: flesch: 36.0 cache: ./cache/cord-260215-gsnjlhjd.txt txt: ./txt/cord-260215-gsnjlhjd.txt summary: Given that respiratory diseases are the commonest causes of critical illness, use of aerosol therapy to provide high local drug concentrations with minimal systemic side effects makes this route an attractive option. The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). NIV non-invasive ventilation, HME heat and moisture exchanger, pMDI pressurized metered dose inhaler, AAD adaptive aerosol device, VMN vibrating mesh nebulizer, DPI dry powder inhaler, PEEP positive end-expiratory pressure Fig. 3 Effects of regional lung aeration and pneumonia on drug concentration in lungs. The patient position, formulation, temperature, endotracheal tube size, presence of airway obstruction or ventilatory asynchrony, flow pattern, respiratory rate, dose and frequency applied or position of the nebulizer in the circuit are important factors that influence delivery to the lung. abstract: Drug dosing in critically ill patients is challenging due to the altered drug pharmacokinetics–pharmacodynamics associated with systemic therapies. For many drug therapies, there is potential to use the respiratory system as an alternative route for drug delivery. Aerosol drug delivery can provide many advantages over conventional therapy. Given that respiratory diseases are the commonest causes of critical illness, use of aerosol therapy to provide high local drug concentrations with minimal systemic side effects makes this route an attractive option. To date, limited evidence has restricted its wider application. The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). This review identifies the relevant factors which require attention for optimization of aerosol drug delivery that can achieve better drug concentrations at the target sites and potentially improve clinical outcomes. url: https://www.ncbi.nlm.nih.gov/pubmed/27716346/ doi: 10.1186/s13054-016-1448-5 id: cord-294617-i8j36bol author: Dhar, Shabir A title: My fear, my morals: a surgeon’s perspective of the COVID crisis date: 2020-10-14 words: 1915.0 sentences: 134.0 pages: flesch: 65.0 cache: ./cache/cord-294617-i8j36bol.txt txt: ./txt/cord-294617-i8j36bol.txt summary: Initially the surgical specialties had a marginal role in the patient care, but as the timeline has expanded, the surgeon is being increasingly called upon to participate in this prolonged tussle [1] . Questions about the pandemic enforced surgical prioritization and the potential problems that the patient might face due to the delay, down the line, continue to challenge our ethical principles. The dominant view in ethics literature is that no individual health professional has a specific positive obligation to treat a patient when doing so places the professional at risk. As the authorities develop and change their policies especially regarding the management of COVID positive pregnant patients, our obstetric surgeons feel as if they are riding an emotional roller coaster. Ethics for surgeons during the COVID-19 pandemic; review article Your country needs you?'' the ethics of allocating staff to high risk clinical roles in the management of patients with COVID-19 abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33050939/ doi: 10.1186/s13010-020-00094-3 id: cord-304593-cugypxp0 author: Dhillon, M. S. title: Changing Pattern of Orthopaedic Trauma Admissions During COVID-19 Pandemic: Experience at a Tertiary Trauma Centre in India date: 2020-08-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: COVID-19 has emerged as a medical threat to mankind, with a serious disruption of lifestyle in 2020. This has not only changed the way we live and work but has also changed the pattern of hospital admissions and medical care. To see if there was significant change in the pattern and management of trauma in our region, we evaluated data from our centre for the lockdown period and compared it with data from the previous year, and also with some available international data. METHODS: We collated data from our Tertiary care hospital for two periods, i.e. from 25th March 2020 to 3rd May 2020 signifying strict lockdown and then from 4th May to 31st May during which some conditional relaxations were given. This was compared to data from similar periods in 2019. We looked at patient demographics, fracture types, injury mechanisms, and even changes in treatment protocols. RESULTS: Significant reductions in caseloads were noted; open injuries were less, road accidents were infrequent, but cases due to falls, especially children and the elderly were still seen, although slightly reduced. The plan to minimize operative interventions could not be fully implemented due to complex nature of trauma seen by us. Only one case of bilateral amputation turned out to be positive, with no infectious consequences to the treating staff. CONCLUSIONS: COVID-19 pandemic led to significant reductions in trauma caseload and change in injury patterns. Doctor responses and patient management needs significant alteration to prevent spread of disease. url: https://doi.org/10.1007/s43465-020-00241-0 doi: 10.1007/s43465-020-00241-0 id: cord-320149-3q4q98a6 author: Di Carlo, Davide Tiziano title: Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature date: 2020-08-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECT: The novel severe acute respiratory syndrome (SARS)-CoV-2 outbreak has been declared a pandemic in March, 2020. An increasing body of evidence suggests that patients with the coronavirus disease (COVID-19) might have a heterogeneous spectrum of neurological symptoms METHODS: A systematic search of two databases was performed for studies published up to May 29th, 2020. PRISMA guidelines were followed. RESULTS: We included 19 studies evaluating 12,157 patients with laboratory-confirmed COVID-19 infections. The median age of patients was 50.3 (IQR 11.9), and the rate of male patients was 50.6% (95% CI 49.2–51.6%). The most common reported comorbidities were hypertension and diabetes (31.1%, 95% CI 30–32.3% and 13.5%, 95% CI 12.3–14.8%, respectively). Headache was reported in 7.5% of patients (95% CI 6.6–8.4%), and dizziness in 6.1% (95% CI 5.1–7.1%). Hypo/anosmia, and gustatory dysfunction were reported in 46.8 and 52.3%, of patients, respectively. Symptoms related to muscular injury ranged between 15 and 30%. Three studies reported radiological confirmed acute cerebrovascular disease in 2% of patients (95% CI 1.6–2.4%). CONCLUSIONS: These data support accumulating evidence that a significant proportion of patients with COVID-19 infection develop neurological manifestations, especially olfactory, and gustatory dysfunction. The pathophysiology of this association is under investigation and warrants additional studies, Physicians should be aware of this possible association because during the epidemic period of COVID-19, early recognition of neurologic manifestations otherwise not explained would raise the suspect of acute respiratory syndrome coronavirus 2 infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00415-020-09978-y) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s00415-020-09978-y doi: 10.1007/s00415-020-09978-y id: cord-342841-b1rucgmg author: Di Carlo, Francesco title: Telepsychiatry and other cutting edge technologies in Covid‐19 pandemic: bridging the distance in mental health assistance date: 2020-09-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: At the end of 2019 a novel coronavirus (COVID‐19) was identified in China. The high potential of human to human transmission led to subsequent COVID‐19 global pandemic. Public health strategies including reduced social contact and lockdown have been adopted in many countries. Nonetheless, social distancing and isolation could also represent risk factors for mental disorders, resulting in loneliness, reduced social support and under‐detection of mental health needs. Along with this, social distancing determines a relevant obstacle for direct access to psychiatric care services. The pandemic generates the urgent need for integrating technology into innovative models of mental healthcare. In this paper we discuss the potential role of telepsychiatry and other cutting‐edge technologies in the management of mental health assistance. We narratively review the literature to examine advantages and risks related to the extensive application of these new therapeutic settings, along with the possible limitations and ethical concerns. Telemental health services may be particularly feasible and appropriate for the support of patients, family members and health‐care providers during this COVID‐19 pandemic. The integration of telepsychiatry with other technological innovations (e.g., mobile apps, virtual reality, big data and artificial intelligence) opens up interesting future perspectives for the improvement of mental health assistance. Telepsychiatry is a promising and growing way to deliver mental health services but is still underused. The COVID‐19 pandemic may serve as an opportunity to introduce and promote, among numerous mental health professionals, the knowledge of the possibilities offered by the digital era. url: https://www.ncbi.nlm.nih.gov/pubmed/32946641/ doi: 10.1111/ijcp.13716 id: cord-315970-m5o962yw author: Di Ciaula, Agostino title: COVID‐19, internists and resilience: the north‐south Italy outbreak. date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: According to data from the World Health Organization, Italy has been particularly affected by the ongoing COVID‐19 pandemic. On April 1(st) 2020, Italy gained, at a world level, the highest number of total confirmed cases (n=110,574) and deaths (n=13,155) since the beginning of the outbreak. The number of cases raised exponentially, reaching a total of 227,364 infected subjects and 32,330 deaths on May, 20. The distribution of infected subjects and deaths, however, was not homogeneous, being respectively about 7‐times and 12‐times higher in northern‐ than in southern regions url: https://doi.org/10.1111/eci.13299 doi: 10.1111/eci.13299 id: cord-273996-z5vlw6nm author: Di Dalmazi, Guido title: Comparison of the effects of lockdown due to COVID-19 on glucose patterns among children, adolescents, and adults with type 1 diabetes: CGM study date: 2020-10-28 words: 4895.0 sentences: 243.0 pages: flesch: 51.0 cache: ./cache/cord-273996-z5vlw6nm.txt txt: ./txt/cord-273996-z5vlw6nm.txt summary: The aims of the study were to investigate continuous glucose monitoring (CGM) metrics in children and adults with T1D during lockdown and to identify their potentially related factors. In adults, considering the changes in SDglu and TIR occurred before and during lockdown, we identified a group with improved TIR and SDglu who performed more physical activity, one with improved glucose variability who was younger than the other patients, and one with worsened glucose variability who showed higher perceived stress than others. ► Time in range and SD of glucose measured by CGM improved in adult patients with type 1 diabetes during lockdown due to the COVID-19 pandemic. To perform unsupervised clustering, we did not consider %CV among parameters of glycemic variability because it was not significantly different between the time periods before and during lockdown neither in the whole groups of patients nor in the three groups divided by age-range (children, teenagers, and adults), according to paired-samples comparison. abstract: INTRODUCTION: The COVID-19 pandemic forced the Italian government to issue extremely restrictive measures on daily activities since 11 March 2020 (‘lockdown’), which may have influenced the metabolic control of type 1 diabetes mellitus (T1D). The aims of the study were to investigate continuous glucose monitoring (CGM) metrics in children and adults with T1D during lockdown and to identify their potentially related factors. RESEARCH DESIGN AND METHODS: We enrolled 130 consecutive patients with T1D (30 children (≤12 years), 24 teenagers (13–17 years), and 76 adults (≥18 years)) using either Dexcom or FreeStyle LibreCGM>70% during the study period, without hybrid closed-loop insulin pump. CGM metrics during the 20 days before and the 20 days after lockdown were calculated. By telephonic contact, we performed validated physical activity and perceived stress questionnaires. RESULTS: In children, significantly lower glucose SD (SDglu) (p=0.029) and time below range (TBR)<54 mg/dL (TBR2) (p=0.029) were detected after lockdown. CGM metrics were comparable in teenagers before and during lockdown. After lockdown, adults improved significantly time in range (TIR) 70–180 mg/dL (p<0.001) and remaining metrics, except percent coefficient of variation and TBR2. In adults, considering the changes in SDglu and TIR occurred before and during lockdown, we identified a group with improved TIR and SDglu who performed more physical activity, one with improved glucose variability who was younger than the other patients, and one with worsened glucose variability who showed higher perceived stress than others. CONCLUSION: In patients with T1D during lockdown, CGM metrics mostly improved in children and adults, whereas it was unchanged in teenagers. In adults, age, physical activity, and perceived stress may be relevant contributing factors. url: https://www.ncbi.nlm.nih.gov/pubmed/33115820/ doi: 10.1136/bmjdrc-2020-001664 id: cord-334881-x9nxxled author: Di Lorenzo, Giuseppe title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: It is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID- 19). METHODS: We conducted a literature review on https://www.ncbi.nlm.nih.gov/pubmed/, https://scholar.google.com, www.arxiv.org, www.biorxiv.org, of all articles published using the keywords COVID-19 therapy or treatment and cancer until May 2, 2020. A total of 205 articles were identified and 53 were included in this review. RESULTS: We describe the ongoing COVID-19 therapies that should be known by oncologists and highlight the potential interactions with antineoplastic drugs, commonly used in clinical practice. The main drug interactions were found with tocilizumab, ruxolitinib and colchicine. Conclusions. The literature provides an inconclusive picture on potential preferred treatments for COVID-19 and their interactions with antineoplastic agents. Future clinical trials are needed to better understand the interactions between different drugs in the context of COVID-19 pandemic. url: https://doi.org/10.1016/j.critrevonc.2020.102991 doi: 10.1016/j.critrevonc.2020.102991 id: cord-258067-par61wwh author: Di Martino, Marcello title: Elective Surgery During the SARS-CoV-2 Pandemic (COVID-19): A Morbimortality Analysis and Recommendations on Patient Prioritisation and Security Measures date: 2020-06-20 words: 3464.0 sentences: 178.0 pages: flesch: 42.0 cache: ./cache/cord-258067-par61wwh.txt txt: ./txt/cord-258067-par61wwh.txt summary: Conclusions The patients undergoing the surgical procedures showed high rates of COVID-19 infection and postoperative complications, especially the patients with oncological diseases. The following variables were analysed: age; sex; functional status (defined according to the ECOG scale) (21); personal background; diagnosis; type of surgical intervention; the timing of SARS-CoV-2 infection; the treatment required (Table 1) ; the severity of the respiratory infection (according to the BRCSS) (20) ; and postoperative complications (according to the Dindo-Clavien classification) (19) . Ten (16.9%) of the oncological patients, one (1%) of those operated on electively for benign diseases and four (7%) of the urgent surgery group presented with a SARS-CoV-2 infection, with statistically significant differences in the infection rate of the three groups (p = 0.004) ( Table 2) . Patients undergoing elective surgery before and during the peak of the COVID-19 pandemic showed a high rate of postoperative complications, with a SARS-CoV-2 infection rate of up to 16% in patients undergoing oncologic surgical procedures. abstract: Abstract Introduction The spread of the SARS-CoV-2 infection (COVID-19) has required adaptation by hospitals affected by the pandemic, which has caused a reduction in elective surgical activity. Methods Retrospective study of patients operated on in the previous month and during the peak of the pandemic. We analysed the COVID-19 infection rate, the severity of respiratory infection according to the Brescia respiratory COVID-19 severity scale, the adopted therapeutic measures and the overall postoperative complications. Results From 17th February to 31st March 2020, there was a progressive decrease in surgical activity, with only 213 patients operated on. This comprised 59 (27.8%) elective operations for oncological diseases, 97 (45.5%) elective operations for benign diseases and 57 (26.7%) as urgent procedures. There was a progressive increase in the rate of infection by COVID-19, with a total of 15 cases (7%). This included 10 patients (16.9%) in the elective group for oncological disease, 1 (1%) in the elective surgery group for benign disease and 4 (7%) in the urgent surgery group (P <.001). Five patients presented with a severe respiratory infection, of which 4 were affected by oncological disease. There were 3 deaths (1.4%), which were all due to the worsening of a respiratory infection. Conclusions The patients undergoing the surgical procedures showed high rates of COVID-19 infection and postoperative complications, especially the patients with oncological diseases. Local resumption of surgical activity must be based on the prioritisation of the cases to be operated on, respecting certain premises of security and optimisation of the available resources. url: https://api.elsevier.com/content/article/pii/S2173507720301216 doi: 10.1016/j.cireng.2020.06.005 id: cord-313836-mcm0xmzw author: Di Micco, Pierpaolo title: Venous Thromboembolism and Its Association with COVID-19: Still an Open Debate date: 2020-09-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Asreported by the World Health Organization, a novel coronavirus (COVID-19) was identified as the causative virus of new viral pneumonia of unknown etiology by Chinese authorities on 7 January 2020. The virus was named COVID-19 and because of its ability to cause severe acute respiratory syndrome (i.e., SARS) this infection has also been defined as SARS-CoV2.Furthermore, an association between COVID-19 infection and venous thromboembolism has been reported in several series around the world.For this reason, methods used to improve diagnostic tools, pharmacological thromboprophylaxis and type of anticoagulants are discussed in this expert opinion. url: https://doi.org/10.3390/medicina56100506 doi: 10.3390/medicina56100506 id: cord-313353-uwwih8v3 author: Di Tano, Giuseppe title: Late Pulmonary Embolism after COVID-19 Pneumonia despite Adequate Rivaroxaban Treatment date: 2020-06-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: SARS-CoV-2 infection may predispose patients to thrombotic disease. Patients with COVID-19 pneumonia who are receiving non-vitamin K antagonists or direct oral anticoagulants for chronic disease are usually switched to heparin treatment during hospitalization. However, information about the most appropriate antithrombotic therapy after the acute infection phase is lacking. CASE DESCRIPTION: We report the case of a patient with chronic atrial fibrillation who was recently hospitalized for severe COVID-19 pneumonia. Four weeks after discharge he experienced an episode of an acute pulmonary embolism while on rivaroxaban therapy with adequate drug plasma levels, and in the absence of strong predisposing risk factors. CONCLUSION: This case highlights the risk of thrombotic complications after COVID-19 infection, raises some concern about their underlying mechanisms, and supports the use of effective anti-thrombotic therapy. LEARNING POINTS: COVID-19 infection is associated with frequent thrombotic events. A pro-coagulative status could be triggered by the persistent inflammatory phase of the infection despite anticoagulation. Adequate antithrombotic therapy is necessary for the prevention of acute and later thrombotic complications and needs close monitoring. url: https://www.ncbi.nlm.nih.gov/pubmed/32665940/ doi: 10.12890/2020_001790 id: cord-308906-et7duogt author: Di, Gaohong title: Simple and Effective Primary Assessment of Emergency Patients in a COVID-19 Outbreak Area: A Retrospective, Observational Study date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The rapid spread of COVID-19 has expanded into a pandemic, for which the main containment strategies to reduce transmission are social distancing and isolation of ill persons. Thousands of medical staff have been infected worldwide. Coronavirus testing kits have been in short supply, and early diagnostic reagents did not have high sensitivity. The aim of this study was to describe the characteristics of patients requiring emergency surgery in a COVID-19 outbreak area. METHODS: We assessed medical data regarding all patients who underwent emergency surgery at the main campus of Wuhan Union Hospital from January 23, 2020, to February 15, 2020. We classified patients based on suspicion of COVID-19 infection (suspected vs not suspected) before they were admitted to the operating room. We used descriptive statistics to analyze the data. Outcomes included the incidence of confirmed COVID-19 infection and length of stay, which were followed until March 25, 2020. RESULTS: Among the 88 emergency patients included in this study, the mean age was 37 years. Twenty-five patients presented with abnormalities observed on chest CT scans and 16 presented with fever. The median wait time for surgery was one day. The median preparation time and median time until short orientation memory concentration test (SOMCT) recovery from anesthesia were 44.0 min and 23.0 min, respectively. The median postoperative length of stay was five days. Compared with patients not suspected of COVID-19 infection, six patients were confirmed to be infected with COVID-19 in the suspected group. No health care workers were infected during this study period. CONCLUSION: Simple identification using temperature screening of patients, respiratory symptoms, and chest CT scans before being admitted for emergency surgery was rapid and effective. Shortened contact times might reduce the risk of infection. Additional investigations with larger samples and improved designs are needed to confirm these observations. url: https://www.ncbi.nlm.nih.gov/pubmed/32903802/ doi: 10.2147/rmhp.s263950 id: cord-016372-opojt70e author: DiMarco, Ross F. title: Postoperative Care of the Cardiac Surgical Patient date: 2010 words: 26961.0 sentences: 1673.0 pages: flesch: 42.0 cache: ./cache/cord-016372-opojt70e.txt txt: ./txt/cord-016372-opojt70e.txt summary: Ninety percent of all postoperative open-heart patients demonstrate a transient low cardiac output (LCO) related to the release of oxygen free radicals in response to the induced inflammatory state of cardiopulmonary bypass, or from ischemic/reperfusion injury as a result of cardioplegic arrest. Doses greater than 2 mcg/ min (>0.03 mcg/kg/min) produce effects that cause vasoconstriction with an increased SVR potentially decreasing cardiac output further as well as increasing myocardial oxygen demand. 88, 89 The indications for IABP counterpulsation are perioperative ischemia, mechanical complications of myocardial infarction (such as acute mitral regurgitation, ventricular septal defect, and cardiogenic shock), postoperative low cardiac output states not responsive to moderate doses of inotropic agents, and for the acute deterioration of myocardial function to provide temporary support or a bridge to transplantation. Inotropic effect of triiodothyronine in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: an initial experience in patients undergoing open-heart surgery abstract: The subspecialty of interventional cardiology began in 1977. Since then, the discipline of interventional cardiology has matured rapidly, particularly with regards to ischemic heart disease. As a result, more patients are undergoing percutaneous catheter interventional therapy for ischemic heart disease and fewer patients are undergoing surgical myocardial revascularization. Those patients referred for surgical revascularization are generally older and have more complex problems. Furthermore, as the population ages more patients are referred to surgery for valvular heart disease. The result of these changes is a population of surgical patients older and sicker than previously treated. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120630/ doi: 10.1007/978-0-387-77893-8_47 id: cord-017374-clctlm5l author: Diamantaki, Eleni title: Acute Respiratory Failure Before ICU Admission: A Practical Approach date: 2017-06-28 words: 4304.0 sentences: 202.0 pages: flesch: 30.0 cache: ./cache/cord-017374-clctlm5l.txt txt: ./txt/cord-017374-clctlm5l.txt summary: Other frequent causes include cardiogenic and noncardiogenic pulmonary edema (acute respiratory distress syndrome [ARDS]), antineoplastic therapy (chemotherapy, radiation therapy)-induced lung injury, cancer-related medical disorders (such as venous thromboembolism, transfusionrelated acute lung injury), and direct involvement of the respiratory system by malignancy and progression of underlying disease. HRCT yields an overall sensitivity and negative predictive value of 90%, in identifying the cause of ARF in cancer patients with lung infiltrates, but low specificity and positive predictive value [7] . Pulmonary toxicity of antineoplastic agents, known as drug-induced toxicity (DIT), is a common cause of respiratory failure in oncologic patients and should be included in the differential diagnosis of ARF in patients who are on or have been treated with antineoplastic agents. Cardiogenic pulmonary edema (CPE) should always be included in the differential diagnosis of acute respiratory failure in oncologic patients, in particular when chemotherapy with cardiotoxic drugs has been preceded. abstract: Acute respiratory failure (ARF) is a common and life-threatening event in cancer patients. It is the leading cause of admission to ICU among the patients with hematologic and solid malignancies and is often associated with poor outcome. Timely identification of the cause of ARF and the initiation of the appropriate therapy may improve the survival. Pulmonary infections represent the leading cause of ARF in those patients, and unless proven otherwise, ARF must be considered as an infectious emergency. Noninfectious causes of ARF include cardiogenic and noncardiogenic pulmonary edema, acute pulmonary embolism, and complications related both to the underlying malignancy and the toxic effects of chemotherapy. This chapter reviews the most common causes of ARF in oncologic patients and discusses the diagnostic and therapeutic approach before ICU admission. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121925/ doi: 10.1007/978-3-319-49256-8_10 id: cord-012117-c693oefo author: Diaz-Padilla, Ivan title: A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors date: 2013-10-01 words: 4691.0 sentences: 273.0 pages: flesch: 49.0 cache: ./cache/cord-012117-c693oefo.txt txt: ./txt/cord-012117-c693oefo.txt summary: Dose-limiting toxicities (DLTs) were defined as adverse events (AEs) as least possibly related to study medication(s) and fulfilling one of the following criteria: a) grade 3 or 4 neutropenia complicated by fever ≥38.5°C, or grade 4 neutropenia of at least 7 days duration; b) grade 3 thrombocytopenia complicated by hemorrhage or grade 4 thrombocytopenia; or c) any grade 3 or higher non-hematologic toxicity (except anorexia, nausea, vomiting, and diarrhea that was not optimally controlled with appropriate medical intervention); d) any ≥grade 3 electrolyte abnormality including hypophosphatemia, hypocalcemia, or hypomagnesemia that did not resolve within 72 h with appropriate therapy or if it was associated with new ECG changes; e) treatment-related toxicities that resulted in failure to receive at least 75 % of the planned doses of RO4929097 and of temsirolimus despite maximal supportive care measures; f) inability to resume dosing for cycle 2 at the current dose level within 14 days due to treatment-related toxicity. abstract: Background To determine the recommended phase II dose (RP2D) and assess the safety, pharmacokinetics (PKs) and pharmacodynamics of RO4929097in combination with temsirolimus. Methods Escalating doses of RO4929097 and temsirolimus were administered at three dose levels. Patients received once daily oral RO4929097 on a 3 days on/4 days off schedule every week, and weekly intravenous temsirolimus. Blood samples were collected for PK analysis. Archival tissue specimens were collected for Notch pathway biomarker analysis and genotyping of frequent oncogenic mutations. Results Seventeen patients with refractory advanced solid tumors were enrolled in three dose levels (DLs): DL1 (RO4929097 10 mg; Temsirolimus 25 mg), DL2 (RO4929097 20 mg; Temsirolimus 25 mg), and DL3 (RO4929097 20 mg; Temsirolimus 37.5 mg). The most common toxicities related to the study drug combination included: fatigue (82 %; grade 3 6 %), mucositis, (71 %; grade 3 6 %), neutropenia (59 %; grade 3 12 %), anemia (59 %; grade 3 0 %), and hypertriglyceridemia (59 %; grade 3 0 %). Two dose-limiting toxicities, grade 3 rash and grade 3 mucositis, were observed in the same patient in the first dose level prompting dose expansion. Eleven patients (73 %) had stable disease as their best response. Co-administration of RO4929097 was associated with increased clearance and reduced exposure to temsirolimus, suggestive of drug-drug interaction via CYP3A4 induction. No correlation between the expression of Notch pathway biomarkers or genotype and time to progression was noted. Conclusions RO4929097 can be safely combined with temsirolimus in patients with advanced solid tumors. The RP2D was established at 20 mg of RO4929097 combined with 37.5 mg of temsirolimus. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10637-013-0001-5) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771370/ doi: 10.1007/s10637-013-0001-5 id: cord-266744-31p212aq author: Dick, Lachlan title: Changes in Emergency General Surgery During Covid-19 in Scotland: A Prospective Cohort Study date: 2020-08-28 words: 2250.0 sentences: 141.0 pages: flesch: 48.0 cache: ./cache/cord-266744-31p212aq.txt txt: ./txt/cord-266744-31p212aq.txt summary: title: Changes in Emergency General Surgery During Covid-19 in Scotland: A Prospective Cohort Study The proportion of patients undergoing surgery increased (19.1 vs 42.3 per cent, p = < 0.05) as did the mean operating time (102.4 vs 145.7 min, p = < 0.05). CONCLUSION: Covid-19 has significantly impacted the number of admissions to emergency general surgery. Of the 36 patients undergoing surgery during 2020, 5 (13.9 per cent) had a change in the surgical procedure. Furthermore, in our cohort, only 50 per cent of patients diagnosed with acute appendicitis underwent Covid-19 testing. Furthermore, 12 (75 per cent) patients were deemed to require surgical management as opposed to the intercollegiate recommendation of a conservative approach [9] again suggesting an increase in severity. Covid-19 has significantly impacted the number of admissions to emergency general surgery. Author''s reply-clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection abstract: INTRODUCTION: Covid-19 has had a significant impact on all aspects of health care. We aimed to characterise the trends in emergency general surgery at a district general hospital in Scotland. METHODS: A prospective cohort study was performed from 23/03/20 to 07/05/20. All emergency general surgery patients were included. Demographics, diagnosis and management were recorded along with Covid-19 testing and results. Thirty-day mortality and readmission rates were also noted. Similar data were collected on patients admitted during the same period in 2019 to allow for comparison. RESULTS: A total of 294 patients were included. There was a 58.3 per cent reduction in admissions when comparing 2020 with 2019 (85 vs 209); however, there was no difference in age (53.2 vs 57.2 years, p = 0.169) or length of stay (4.8 vs 3.7 days, p = 0.133). During 2020, the diagnosis of appendicitis increased (4.3 vs 18.8 per cent, p = < 0.05) as did severity (0 per cent > grade 1 vs 58.3 per cent > grade 1, p = < 0.05). The proportion of patients undergoing surgery increased (19.1 vs 42.3 per cent, p = < 0.05) as did the mean operating time (102.4 vs 145.7 min, p = < 0.05). Surgery was performed in 1 confirmed and 1 suspected Covid-19 patient. The latter died within 30 days. There were no 30-day readmissions with Covid-19 symptoms. CONCLUSION: Covid-19 has significantly impacted the number of admissions to emergency general surgery. However, emergency operating continues to be needed at pre-Covid-19 levels and as such provisions need to be made to facilitate this. url: https://www.ncbi.nlm.nih.gov/pubmed/32860140/ doi: 10.1007/s00268-020-05760-3 id: cord-293143-1k170shh author: Dieninghoff, Doris title: Fatal HBoV-1 infection in adult female cystic fibrosis patient date: 2016-07-18 words: 1752.0 sentences: 90.0 pages: flesch: 47.0 cache: ./cache/cord-293143-1k170shh.txt txt: ./txt/cord-293143-1k170shh.txt summary: A clinical case of fatal HBoV infection in an adult cystic-fibrosis patient awaiting lung transplantation is reported. A clinical case of fatal HBoV infection in an adult cystic-fibrosis patient awaiting lung transplantation is reported. The human bocavirus (HBoV) is a parvovirus that is associated with acute and chronic infections of the upper and lower respiratory tract, persists in some tissues and solid cancers and putatively may play an aetiologic role in the development of idiopathic lung fibrosis [1] [2] [3] [4] [5] [6] [7] [8] . To date, no animal model exists, thus studies on the pathology of HBoV infections are limited to clinical studies, case descriptions, and air-liquid interface cell culture models that have been shown to mimic some important steps of the infection cycle [1, 7, [10] [11] [12] . abstract: A clinical case of fatal HBoV infection in an adult cystic-fibrosis patient awaiting lung transplantation is reported. The case is important as the genetic background of the underlying disease is congruent with the background of the sole permissive permanent cell culture CuFi-8 which originates also from a CF patient donor. url: https://www.ncbi.nlm.nih.gov/pubmed/32337159/ doi: 10.1016/j.ehpc.2016.07.001 id: cord-333453-v3gap8kj author: Dima, Mirabela title: First neonates with severe acute respiratory syndrome coronavirus 2 infection in Romania: Three case reports date: 2020-08-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: RATIONALE: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which quickly spread throughout the world, has been putting medical workers all over the world in difficulty because of the high number of cases combined with the lack of information about the disease. Although pediatric cases are rare, the group age under 12 months has been in general more susceptible to develop severe forms of the disease compared with the patients in the age interval of 1 to 18 years. PATIENT CONCERNS: Three newborns have been tested positive for SARS-CoV-2 infection. One of them presented bilateral decreased air entry, while the other 2 had no respiratory symptomatology. All 3 developed diaper erythema and oral candidiasis. DIAGNOSIS: For building up the report, newborns that were positive for coronavirus disease 2019 (COVID-19) infection were included in the case series. The chest X-ray of the symptomatic patient revealed a medium degree of hilar parenchymal infiltration and a slight infiltration of the visceral pleura. INTERVENTIONS: The patients were admitted in our isolated neonatology ward. All of them received antifungal treatment for the oral candidiasis and topic cream for diaper erythema. The symptomatic patient also received prophylactic antibiotherapy, human immunoglobulins, aminophylline, and parenteral nutrition. OUTCOMES: All 3 neonates were discharged after 2 consecutive negative tests for SARS-CoV-2. Patients 1 and 2 fully recovered, whereas the condition of patient 3 improved. LESSONS: Even if there are only a few reported cases of neonates infected with COVID-19 and most of them present mild manifestations, newborns need a more careful insight because of the nonspecific symptomatology. url: https://www.ncbi.nlm.nih.gov/pubmed/32871986/ doi: 10.1097/md.0000000000021284 id: cord-337431-3rrvm787 author: Dimopoulos, G title: Viral Profile of COPD Exacerbations According to Patients§ date: 2015-02-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND : To compare the differences between elderly and non-elderly patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) due to viral infections. METHODS : Patients with chronic obstructive pulmonary disease (COPD) exacerbation were recruited and classified as elderly (>65 years) and non-elderly (≤ 65 years). Sputum and oropharyngeal samples were assessed, PCR for respiratory viruses and cultures for common pathogens were performed. RESULTS : 247 patients (median age: 69.3±9.5 years) were recruited and categorized into group A: non-elderly patients [n=81 (32.8%), median age 58±5.99] and group B: elderly patients [n=166 (67.2%), median age 74.8±4.8] years. In 133 (53.8%) patients a viral infection was identified and in 34 (13.8%) a bacterial pathogen was isolated from cultures. In 18 (7.3%) patients a double infection (bacterial+viral) was identified. In group B, the presence of cardiac failure (46.6% vs 28.3%, p<0.001), renal failure (10.5% vs 4%, p=0.03), bacterial co-infection (13.8% vs 7.4%, p=0.04), influenza vaccination rates (45.5% vs 215, p<0.001), and longer hospital stay (8.4±4.4 vs 7.5±3.2 days, p=0.02) were higher than group A. The overall rate of viral infections did not differ according to age. A trend to higher rates of infection with parainfluenza 3 [19 (20%) patients in group B vs3 (7.5%) patients in group A, p=0.04] was observed in older patients. CONCLUSION : No differences on the rate and type of viral infections were noted for elderly vs non elderly patients. However, they tended to have more bacterial co-infections that led to AECOPD and longer hospitalization stays compared to non-elderly patients. url: https://www.ncbi.nlm.nih.gov/pubmed/25741393/ doi: 10.2174/1874306401509010001 id: cord-301402-andxwyi3 author: Ding, Benjamin Tze Keong title: Operating in a Pandemic: Lessons and Strategies from an Orthopaedic Unit at the Epicenter of COVID-19 in Singapore date: 2020-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: ➤. With severe limitations in manpower, facilities, and equipment, and the concern for nosocomial transmission, operating in a pandemic is fraught with danger from multiple fronts. ➤. Strategies to mitigate nosocomial spread include prioritization of existing patients, triaging and treatment of new patient encounters, infection control protocols, perioperative considerations, manpower management, and novel strategies for interdisciplinary interaction and education. ➤. The decision to proceed with or postpone surgery should be based on the urgency of the surgical procedure and the physiological health of the patient. ➤. When performing an operation on a patient who has suspected or confirmed infection with novel coronavirus disease 2019 (COVID-19), personal protection equipment should include hair covers, face shields or goggles, N95 respirator masks, a blood-borne pathogen-resistant surgical gown, shoe covers, and double-gloving with single-use gloves. ➤. Loose-fitting, powered air-purifying respirators should be considered for prolonged surgeries. ➤. An astutely formulated and comprehensive business continuity plan is an orthopaedic unit’s best strategy for maintaining critical standards, discipline, and morale in severe and prolonged outbreaks. url: https://www.ncbi.nlm.nih.gov/pubmed/32618915/ doi: 10.2106/jbjs.20.00568 id: cord-289088-7uoia564 author: Ding, Qiang title: The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China date: 2020-03-30 words: 1517.0 sentences: 88.0 pages: flesch: 49.0 cache: ./cache/cord-289088-7uoia564.txt txt: ./txt/cord-289088-7uoia564.txt summary: title: The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China In conclusion, those patients with both COVID‐19 and influenza virus infection did not appear to show a more severe condition because based on the laboratory findings, imaging studies, and patient prognosis, they showed similar clinical characteristics as those patients with COVID‐19 infection only. In this study, we describe the clinical characteristics of those patients who got infected with COVID-19 as well as influenza virus. On one hand, this study showed that the clinical characteristics of patients with both COVID-19 and influenza virus infection were similar to those of COVID-19 infection, but the symptoms of nasal tampon and pharyngalgia may be more prone to appear, which would be more convinced when more cases included. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China abstract: The outbreak of 2019 novel coronavirus (COVID‐19) infection emerged in Wuhan, China, in December 2019. Since then the novel coronavirus pneumonia disease has been spreading quickly and many countries and territories have been affected, with major outbreaks in China, South Korea, Italy, and Iran. Influenza virus has been known as a common pathogen in winter and it can cause pneumonia. It was found clinically that very few patients were diagnosed with both COVID‐19 and influenza virus. A total of 5 of the 115 patients confirmed with COVID‐19 were also diagnosed with influenza virus infection, with three cases being influenza A and two cases being influenza B. In this study, we describe the clinical characteristics of those patients who got infected with COVID‐19 as well as influenza virus. Common symptoms at onset of illness included fever (five [100%] patients), cough (five [100%] patients), shortness of breath (five [100%] patients), nasal tampon (three [60%] patients), pharyngalgia (three [60%] patients), myalgia (two [40%] patients), fatigue (two [40%] patients), headache (two [40%] patients), and expectoration (two [40%] patients). The laboratory results showed that compared to the normal values, the patients' lymphocytes were reduced (four [80%] patients), and liver functions alanine aminotransferase and aspartate aminotransferase (two [40%] patients and two [40%] patients) and C‐reactive protein (four [80%] patients) were increased when admitted to hospital. They stayed in the hospital for 14, 30, 17, 12, and 19 days (28.4 ± 7.02), respectively. The main complications for the patients were acute respiratory distress syndrome (one [20%] patients), acute liver injury (three [60%] patients), and diarrhea (two [40%] patients). All patients were given antiviral therapy (including oseltamivir), oxygen inhalation, and antibiotics. Three patients were treated with glucocorticoids including two treated with oral glucocorticoids. One of the five patients had transient hemostatic medication for hemoptysis. Fortunately, all patients did not need intensive care unit and were discharged from the hospital without death. In conclusion, those patients with both COVID‐19 and influenza virus infection did not appear to show a more severe condition because based on the laboratory findings, imaging studies, and patient prognosis, they showed similar clinical characteristics as those patients with COVID‐19 infection only. However, it is worth noting that the symptoms of nasal tampon and pharyngalgia may be more prone to appear for those coinfection patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32196707/ doi: 10.1002/jmv.25781 id: cord-017518-u2gsa4lg author: Divatia, J. V. title: Nosocomial Infections and Ventilator-Associated Pneumonia in Cancer Patients date: 2019-07-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Nosocomial infections or healthcare-acquired infections are a common cause of increased morbidity and mortality among hospitalized patients. Cancer patients are at an increased risk for these infections due to their immunosuppressed states. Considering these adverse effects on and the socioeconomic burden, efforts should be made to minimize the transmission of these infections and make the hospitals a safer environment. These infection rates can be significantly reduced by the implementing and improving compliance with the “care bundles.” This chapter will address the common nosocomial infections such as ventilator-associated pneumonia (VAP), catheter-associated urinary tract infections (CAUTI), and surgical site infections (SSI), including preventive strategies and care bundles for the same. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122096/ doi: 10.1007/978-3-319-74588-6_125 id: cord-017324-l3d3t4wh author: DjukanoviĆ, Ljubica title: Balkan nephropathy date: 2008 words: 6838.0 sentences: 425.0 pages: flesch: 42.0 cache: ./cache/cord-017324-l3d3t4wh.txt txt: ./txt/cord-017324-l3d3t4wh.txt summary: Balkan nephropathy does not spread beyond its already defined foci; the disease is distributed mosaically : non-endemic villages exist in the most affected regions, and there are spared families and households in the most affected settlements. Optic microscopic, immunofluorescent and electron microscopic studies of renal biopsies in children aged 5-15 from affected families in endemic regions failed to detect any Balkan nephropathy related changes [79] . The diagnosis of Balkan nephropathy is now established according to the first two criteria (residence in endemic village and positive family history) suggested by Danilović [106] , presence of tubular proteinuria and ruling out other renal diseases. Although no specific indicators of Balkan nephropathy have been recognized, epidemiological data, familial history as well as clinical characteristics of the disease enable differential diagnosis. However, recent studies indicated that patients with Balkan nephropathy are at increased risk for the development of upper urothelial tumors in both native and transplanted kidneys [117] . abstract: Balkan (or endemic) nephropathy is a chronic tubulointerstitial disease of unknown, presumably exotoxic etiology. It has been shown to exist only in some parts of the southeastern Europe. While there have been many meetings and papers [1, 2] concerning both cause and treatment of Balkan nephropathy, sociopolitical turmoil, including wars, and economical hardship prevented any meaningful research on the problem during the 1990’s. Thus, despite numerous proceedings and a large number of publications on the subject, many features of Balkan nephropathy, its etiology and natural history in particular, remained nearly as mysterious as when described in the mid-fifties. Meetings organized by international organizations [3-7] had a key role in informing the international scientific community on the disease. A recent source of information is a bilingual (in English and Serbian) monograph published in 2000 [8]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121851/ doi: 10.1007/978-0-387-84843-3_38 id: cord-326272-ya3r0h1t author: Dobesh, Paul P. title: Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID‐19 date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)has led to a world‐wide pandemic, and patients with the infection are referred to as having COVID‐19. Although COVID‐19 is commonly considered a respiratory disease, there is clearly a thrombotic potential that was not expected. The pathophysiology of the disease and subsequent coagulopathy produce an inflammatory, hypercoagulable, and hypofibrinolytic state. Several observational studies have demonstrated surprisingly high rates of venous thromboembolism (VTE) in both general ward and intensive care patients with COVID‐19. Many of these observational studies demonstrate high rates of VTE despite patients being on standard, or even higher intensity, pharmacologic VTE prophylaxis. Fibrinolytic therapy has also been used in patients with acute respiratory distress syndrome. Unfortunately, high quality randomized controlled trials are lacking. A literature search was performed to provide the most up‐to‐date information on the pathophysiology, coagulopathy, risk of VTE, and prevention and treatment of VTE in patients with COVID‐19. These topics are reviewed in detail, along with practical issues of anticoagulant selection and duration. Although a number of international organizations have produced guideline or consensus statements, they do not all cover the same issues regarding anticoagulant therapy for patients with COVID‐19, and they do not all agree. These statements and the most recent literature are combined into a list of clinical considerations that clinicians can use for the prevention and treatment of VTE in patients with COVID‐19. url: https://doi.org/10.1002/phar.2465 doi: 10.1002/phar.2465 id: cord-018595-x3tleomb author: Dodiuk-Gad, Roni P. title: Adverse Medication Reactions date: 2017-04-25 words: 16304.0 sentences: 910.0 pages: flesch: 39.0 cache: ./cache/cord-018595-x3tleomb.txt txt: ./txt/cord-018595-x3tleomb.txt summary: 2. Delayed-type drug hypersensitivity: Delayed-type drug hypersensitivity reactions usually take several days to weeks following drug exposure, with variable clinical presentations that may include Maculopapular Eruption (MPE), Fixed Drug Eruption (FDE), Acute Generalized Exanthematous Pustulosis (AGEP), Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Examples of strong associations of HLA alleles with specific drug-induced hypersensitivity reactions include abacavir, nevirapine, carbamazepine, and allopurinol (Table 25. [61] , who reported the weak associations of HLA-A29, B12, and MPE maculopapular drug eruption, DRESS drug reaction with eosinophilia and systemic symptoms, SJS/TEN Stevens-Johnson syndrome/toxic epidermal necrolysis DR7 in sulfonamide-related TEN, and HLA-A2, B12 in oxicam-related TEN in Europeans [61] . Drug specific cytotoxic T-cells in the skin lesions of a patient with toxic epidermal necrolysis abstract: Cutaneous adverse drug reactions (ADRs) are among the most frequent adverse reactions in patients receiving drug therapy. They have a broad spectrum of clinical manifestations, are caused by various drugs, and result from different pathophysiological mechanisms. Hence, their diagnosis and management is challenging. Severe cutaneous ADRs comprise a group of diseases with major morbidity and mortality, reaching 30 % mortality rate in cases of Toxic Epidermal Necrolysis. This chapter covers the terminology, epidemiology, pathogenesis and classification of cutaneous ADR, describes the severe cutaneous ADRs and the clinical and laboratory approach to the patient with cutaneous ADR and presents the translation of laboratory-based discoveries on the genetic predisposition and pathogenesis of cutaneous ADRs to clinical management guidelines. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123512/ doi: 10.1007/978-3-319-29785-9_25 id: cord-007786-cu831tl7 author: Dondorp, Arjen M. title: Management of Severe Malaria and Severe Dengue in Resource-Limited Settings date: 2019-02-09 words: 4114.0 sentences: 205.0 pages: flesch: 43.0 cache: ./cache/cord-007786-cu831tl7.txt txt: ./txt/cord-007786-cu831tl7.txt summary: We suggest that in patients with hypotensive shock, fluid bolus therapy (30 mL/kg) with isotonic crystalloids be commenced (ungraded) and, if available, early initiation of vasopressor medication (ungraded) Timing of enteral feeding in cerebral malaria We suggest not to use a strategy of permissive hypercapnia to achieve ventilation with low tidal volumes in patients with cerebral malaria, because of the high incidence of brain swelling in these patients (ungraded) Fluid management in severe dengue We recommend not to use prophylactic platelet transfusion for thrombocytopenia in the absence of active bleeding complications or other risk factors (uncontrolled arterial hypertension, recent stroke, head trauma or surgery, continuation of an anticoagulant treatment, existing hemorrhagic diathesis) (1B) acidosis [14, 15] , and transpulmonary thermodilution-guided rapid fluid resuscitation resulted in pulmonary edema in 8/28 (29%) patients [15] . There are several randomized clinical trials comparing crystalloid with colloid fluid management for the treatment of patients with severe dengue and compensated shock. abstract: This chapter summarizes recommendations on important aspects of the management of patients with severe malaria and severe dengue. Severe falciparum malaria requires rapid parasitological diagnosis by microscopy or rapid diagnostic test (RCT) and prompt initiation of parenteral artesunate. Fluid bolus therapy should be avoided in patients without hypotensive shock, and we suggest initial (24 h) crystalloid fluid therapy of 2–4 mL/kg/h, which may subsequently be reduced to 1 mL/kg/h in patients receiving additional fluids, e.g., through enteral tube feeding. In the minority of those patients presenting with hypotensive shock, we suggest fluid bolus therapy (30 mL/kg) with an isotonic crystalloid and early initiation of vasopressor support. Enteral feeding in non-intubated adult patients with cerebral malaria can start after 60 h, to avoid aspiration pneumonia. There are insufficient data to suggest this in pediatric cerebral malaria. The diagnosis of severe dengue is commonly with a combined dengue antigen (NS1) and antibody RDT. No antiviral treatment is currently available. Dengue shock results from capillary leakage, although hemorrhage or depression of myocardial contractility can contribute. The World Health Organization guidelines recommend restoration of the circulation guided by pulse pressure, capillary refill time, hematocrit, and urine output. Large (>15 mL/kg) rapid (<30 min) fluid boluses should be avoided, but prompt fluid administration with crystalloids is essential and should be restricted as soon as the critical phase is over to avoid pulmonary edema. Corticosteroids are not recommended, neither is platelet transfusion for thrombocytopenia in the absence of active bleeding or other risk factors. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123178/ doi: 10.1007/978-3-030-03143-5_9 id: cord-315157-2p45frlk author: Donell, Simon T. title: Preparation for the next COVID-19 wave: The European Hip Society and European Knee Associates recommendations date: 2020-08-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To plan for the continuance of elective hip and knee arthroplasty during a resurgence or new wave of COVID-19 infections. METHOD: A systematic review was conducted using the terms “COVID-19” or “SARS-Cov-2” and “second wave”. No relevant citations were found to inform on recommendations the plan. Therefore, an expert panel of the European Hip Society and the European Knee Associates was formed to provide the recommendations. RESULTS: Overall, the recommendations consider three phases; review of the first wave, preparation for the next wave, and during the next wave. International and national policies will drive most of the management. The recommendations focus on the preparation phase and, in particular, the actions that the individual surgeon needs to undertake to continue with, and practice, elective arthroplasty during the next wave, as well as planning their personal and their family’s lives. The recommendations expect rigorous data collection during the next wave, so that a cycle of continuous improvement is created to take account of any future waves. CONCLUSIONS: The recommendations for planning to continue elective hip and knee arthroplasty during a new phase of the SARS-Cov-2 pandemic provide a framework to reduce the risk of a complete shutdown of elective surgery. This involves engaging with hospital managers and other specialities in the planning process. Individuals have responsibilities to themselves, their colleagues, and their families, beyond the actual delivery of elective arthroplasty. url: https://doi.org/10.1007/s00167-020-06213-z doi: 10.1007/s00167-020-06213-z id: cord-321788-z2y1ywdq author: Dong, J. title: Chest CT Scan of Hospitalized Patients with COVID-19: A Case-Control Study date: 2020-04-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction: This paper sought to investigate the clinical characteristic differences between suspected and confirmed patients with COVID-19 from CT scan to prevent and treat this infectious disease, since the coronavirus outbreak in the world has seriously affected the quality of life. Methods: We proposed to use a retrospective case-control study to give a comparison between suspected patients and confirmed patients in the clinical characteristics. Results: (56%) patients were confirmed for COVID-19 from suspected 167 patients. We find that elder people were more likely to be infected by COVID-19. Among the confirmed 94 patients, 2 (2%) patients were admitted to an intensive care unit, and 0 (0%) patients died during the study period. We find that images of CT scan of patients with a COVID-19 are significantly different from patients without a COVID-19. Conclusions: To our best knowledge, it is the first time to use the case-control design to study the coronavirus disease, since it is particularly appropriate for investigating infectious disease outbreaks. The clinical treatment experience in this study can supply a guideline for treating COVID-19 as the number of the infected patients is increasing in the world. Compared with other studies, we find that the mortality rate and the intensive care unit rate can be reduced if patients can be treated timely in the right identification and detection with nucleic acid testing and chest CT scan. Therefore, we recommend nucleic acid testing and chest CT scan for the clinical treatment practice from this successful clinical treatment study. url: http://medrxiv.org/cgi/content/short/2020.04.07.20056762v1?rss=1 doi: 10.1101/2020.04.07.20056762 id: cord-261006-2xh3f07i author: Dong, Zhiyong title: Recommendations to Manage Patients for Bariatric Surgery in the COVID-19 Pandemic: Experience from China date: 2020-06-06 words: 1365.0 sentences: 85.0 pages: flesch: 48.0 cache: ./cache/cord-261006-2xh3f07i.txt txt: ./txt/cord-261006-2xh3f07i.txt summary: title: Recommendations to Manage Patients for Bariatric Surgery in the COVID-19 Pandemic: Experience from China For the prehospital evaluation, we recommend (1) that consultation be conducted virtually by means of WeChat, email, or telephone, to investigate whether patients may have COVID-19 by asking about symptoms or any history of recent travel to epidemic areas. For the preoperative evaluation, we recommend (1) reevaluation of epidemiological information to exclude COVID-19-infected if necessary; (2) re-evaluate whether there is any history of fever or respiratory symptoms; confirm the results of lung CT, nucleic acid test, routine blood examinations, and other relevant tests. Repeat the PCR if necessary in case of a false positive; (3) complete a preoperative examination of cardiopulmonary function; use continuous positive airway pressure (CPAP) to improve lung ventilation and systemic hypoxia in cases of obesity hypoventilation syndrome (OHS); for cardiopulmonary insufficiency or severe complications, there should be an online consultation of the departments of anesthesia, respiratory, cardiovascular, endocrine, and other relevant departments to plan the surgical timing and provide individualized diagnosis and treatment [12] . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32506347/ doi: 10.1007/s11695-020-04741-8 id: cord-312212-h5j4f0xq author: Dooley, Anjali B. title: Use of Telemedicine for Sexual Medicine Patients date: 2020-07-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Telemedicine (TM) will play a significant role in contemporary practices that diagnose and treat sexual medicine patients. Although only a small percentage of urologists, sex therapists, social workers, psychiatrists, gynecologists, and urogynecologists currently use TM, many more practices are going to embrace this technology in the near future. This article will discuss the process for implementing TM in sexual medicine with minimal time, energy, effort, and expense. We will also examine compliance and legal issues associated with implementing TM in practice and how to code for TM services based on regulatory guidelines. OBJECTIVES: The purpose of this article is to improve the understanding of the concept and the trends of using TM to provide care for sexual medicine patients. METHODS: The study involves a literature review focussing on the new Centers for Medicare and Medicaid Services guidelines including the relaxation of the Health Insurance Portability and Accountability Act requirements. RESULTS: COVID-19 has changed the doctor-patient relationship especially in the area of sexual medicine. There are many patients with sexual medicine conditions that are amenable to the use of TM methods. CONCLUSION: Virtual visit utilizing audiovisual telecommunications is a very attractive approach for sexual medicine patients. Many patients with sexual medicine problems are no longer going to accept the antiquated method of healthcare involving making an appointment, visiting a brick-and-mortar facility, and the requirement of having a physical examination. The new normal will be communicating with patients by utilizing TM. Dooley AB, Houssaye N de la, Baum N. Use of Telemedicine for Sexual Medicine Patients. Sex Med Rev 2020;XX:XXX–XXX. url: https://doi.org/10.1016/j.sxmr.2020.06.001 doi: 10.1016/j.sxmr.2020.06.001 id: cord-291588-tp89j1kk author: Dorche, Maryam Sharifian title: Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic date: 2020-08-07 words: 5579.0 sentences: 431.0 pages: flesch: 42.0 cache: ./cache/cord-291588-tp89j1kk.txt txt: ./txt/cord-291588-tp89j1kk.txt summary: During the current pandemic, 370 patients with SARS-CoV-2 infection out of 37 studies (Table 3) were reported to suffer from AIS or transient ischemic attack (TIA). (145) Acute Necrotizing Encephalopathy(ANE) which was reported in 8 patients (Table 3) with COVID-19 is a distinct entity defined as rapid onset of neurological symptoms often secondary to a viral infection such as herpes viruses and influenza. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series Evolution and resolution of brain involvement associated with SARS-CoV2 infection: A close Clinical -Paraclinical follow up study of a case EEG Findings in Acutely Ill Patients Investigated for SARS-CoV-2/COVID-19: A Small Case Series Preliminary Report. Guillain-Barré syndrome in a patient infected with SARS-CoV-2, a case report Guillain-Barré Syndrome as a Neurological Complication of Novel COVID-19 Infection: A Case Report and Review of the Literature abstract: INTRODUCTION: Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. However, there is growing evidence indicating neurological manifestations occur in patients with COVID-19. Similarly, the other coronaviruses (CoV) epidemics; severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) have been associated with neurological complications. METHODS: This systematic review serves to summarize available information regarding the potential effects of different types of CoV on the nervous system and describes the range of clinical neurological complications that have been reported thus far in COVID-19. RESULTS: Two hundred and twenty-five studies on CoV infections associated neurological manifestations in human were reviewed. Of those, 208 articles were pertinent to COVID-19. The most common neurological complaints in COVID-19 were anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported. CONCLUSION: There are several similarities between neurological complications after SARS-CoV-1, MERS-CoV and COVID-19, however, the scope of the epidemics and number of patients are very different. Reports on the neurological complications after and during COVID-19 are growing on a daily basis. Accordingly, comprehensive knowledge of these complications will help health care providers to be attentive to these complications and diagnose and treat them timely. url: https://api.elsevier.com/content/article/pii/S0022510X20304226 doi: 10.1016/j.jns.2020.117085 id: cord-018545-fk17n2bx author: Dorofaeff, Tavey title: Infections in the PICU date: 2012 words: 14180.0 sentences: 981.0 pages: flesch: 47.0 cache: ./cache/cord-018545-fk17n2bx.txt txt: ./txt/cord-018545-fk17n2bx.txt summary: Herpes Simplex Virus (HSV, types 1 and 2) (a) Systemic infection in the neonate with shock and coagulopathy and severe liver failure (b) Encephalitis, hepatitis (c) Local (mouth, esophagus, larynx, lungs, heart, liver, kidneys, CNS) or systemic disease in organ and stem cell transplant and immunocompromised patients 2. Pneumonia means inflammation of the lung parenchyma caused by infection and the diagnosis is made clinically in a febrile child with respiratory signs and symptoms who has evidence of consolidation on CXR. • Development of an empyema or less commonly a lung abscess • Underlying lung disease such as: bronchopulmonary dysplasia (BPD, in ex-premies), cystic fibrosis, inhaled foreign body, tracheobronchomalacia or post tracheal surgery, or infected congenital lung cyst • Diagnosed or undiagnosed immunodeficiency states (primary, HIV, leukemia) • Children with neuromuscular diseases, weakness, or spasticity such as muscular dystrophies, myasthenia, spinal muscular atrophy, or cerebral palsy • Inappropriate antibiotics, inappropriately low dose or resistant bacteria • Non bacterial pneumonia (viral pneumonia or alternative pathogen such as Tuberculosis) abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123446/ doi: 10.1007/978-3-642-02202-9_268 id: cord-351184-kcc3p3ow author: Dotters-Katz, Sarah K. title: Considerations for Obstetric Care during the COVID-19 Pandemic date: 2020-04-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus disease 2019 (COVID-19) is a growing pandemic that is impacting daily life across the globe. Though disease is often mild, in high-risk populations, severe disease often leads to intubation, intensive care admission (ICU) admission, and in many cases death. The implications for pregnancy remain largely unknown. Early data suggest that COVID-19 may not pose increased risk in the pregnant population. Vertical transmission has not been confirmed. Because no treatment, no vaccine and no herd immunity exist, social distancing is the best mechanism available to protect patients and health care workers from infection. This review will discuss what is known about the virus as it relates to pregnancy and then consider management considerations based on these data. Key Points: COVID-19 severity in pregnancy is unclear. Social distancing is the best protective mechanism. No clear evidence of vertical transmission exists. Mother/baby separation avoids transmission. url: https://www.ncbi.nlm.nih.gov/pubmed/32303077/ doi: 10.1055/s-0040-1710051 id: cord-328294-gii1b7s7 author: Doty, Richard L. title: Olfaction and Its Alteration by Nasal Obstruction, Rhinitis, and Rhinosinusitis date: 2009-01-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The sense of smell has been largely ignored by otorhinolaryngologists, even though 1) its medical stewardship falls within their specialty's purview, 2) olfactory dysfunction is not uncommon in the general population, and 3) disorders of olfaction have significant quality of life, nutritional, and safety consequences. This report provides a succinct overview of the major intranasal neural systems present in humans (namely, cranial nerves O, I, and V, and the nonfunctional accessory [vomeronasal] organ system), along with a summary of notable findings resulting from the application of modern olfactory tests to patient populations, emphasizing diseases of the nose. Such tests have led to the discovery of significant influences of age, gender, smoking, toxic exposure, and genetics on the ability to smell. Within the field of otorhinolaryngology, they have revealed that 1) surgical and medical interventions in patients with rhinosinusitis do not, on average, lead to complete recovery of olfactory function, despite common beliefs to the contrary, and 2) associations are generally lacking between measures of airway patency and olfactory function in such cases. These findings have thrown into question the dogma that olfactory loss in rhinosinusitis is attributable primarily to blockage of airflow to the receptors and have led to histopathological studies demonstrating significant olfactory epithelial compromise in sinonasal syndromes. url: https://www.ncbi.nlm.nih.gov/pubmed/11224769/ doi: 10.1097/00005537-200103000-00008 id: cord-307100-w33e2078 author: Douedi, Steven title: Successful Maternal and Fetal Outcomes in COVID-19 Pregnant Women: An Institutional Approach date: 2020-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Case series Patients: Female, 26-year-old • Female, 27-year-old • Female, 19-year-old Final Diagnosis: Acute Respiratory Distress Syndrome (ARDS) • COVID-19 Symptoms: Fever • hypoxia • shortness of breath Medication: — Clinical Procedure: Cesarian section • mechanical ventilation Specialty: Critical Care Medicine • Infectious Diseases • Medicine, General and Internal • Obstetrics and Gynecology OBJECTIVE: Management of emergency care BACKGROUND: Novel Coronavirus 2019 (COVID-19) has been defined as a pandemic infecting millions of individuals with a significantly high mortality and morbidity rate. Treatment and management for pregnant patients infected with COVID-19 has been poorly described in the literature. Furthermore, vertical transmission of COVID-19 to the fetus has been poorly described. The purpose of this case series is to present 3 patients in their trimester who underwent emergent cesarean sections and were successfully managed in the intensive care unit. CASE REPORTS: We present the cases of 3 patients diagnosed with COVID-19 via RT-PCR in their third trimester of pregnancy. All patients underwent emergent cesarean sections and were managed on mechanical ventilation in the intensive care unit and eventually discharged in stable condition. CONCLUSIONS: Early cesarean section and aggressive management with mechanical ventilation has been shown to be very beneficial for mothers diagnosed with COVID-19 and their infants. All 3 patients were successfully extubated, and all 3 infants tested negative for COVID-19, suggesting no vertical transmission; although, further studies are needed to confirm this finding. url: https://www.ncbi.nlm.nih.gov/pubmed/32716009/ doi: 10.12659/ajcr.925513 id: cord-328640-4g7revha author: Douedi, Steven title: Novel coronavirus 2019 (COVID-19): A case report and review of treatments date: 2020-05-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: RATIONALE: Novel coronavirus 2019 (COVID-19) also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, non-segmented positive-sense RNA virus belonging to the beta-coronaviridae family. This virus is known to cause severe bilateral pneumonia and acute respiratory distress syndrome (ARDS) which can lead to difficulty breathing requiring mechanical ventilation and intensive care unit management. PATIENT CONCERNS: A 77-year-old female with a history of hypertension and hyperlipidemia who presented as a transfer to our hospital facility with worsening fevers, cough, and respiratory distress. DIAGNOSIS: Chest X-rays revealed bilateral infiltrates worse at the lung bases and CT scan of the chest showed bilateral ground-glass opacities consistent with COVID-19. While our testing revealed a negative COVID-19 result at our institution, the result at a previous hospital returned a positive result. INTERVENTIONS: She was being treated aggressively in the intensive care unit with high dose intravenous ascorbic acid, hydroxychloroquine, and anti-interleukin-6 monoclonal antibody. She also received a loading dose of remdesivir however was unable to complete the course due to organ failure and requirement of vasopressors for hemodynamic stability. OUTCOMES: She remained critically ill and was eventually placed on comfort care as per the family's wishes and passed away. LESSONS: With a rapidly growing death rate and more than 200,000 confirmed cases worldwide, COVID-19 has become a global pandemic and major hit to our healthcare systems. While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. The alarming increase in cases per day adds additional pressure to find a cure and decrease the global health burden and mortality rate. url: https://doi.org/10.1097/md.0000000000020207 doi: 10.1097/md.0000000000020207 id: cord-257336-rpx71ww5 author: Doukas, Sotirios G. title: E-cigarette or vaping induced lung injury: A case series and literature review date: 2020-10-03 words: 4718.0 sentences: 231.0 pages: flesch: 48.0 cache: ./cache/cord-257336-rpx71ww5.txt txt: ./txt/cord-257336-rpx71ww5.txt summary: Given the rapidly growing number of cases, a detailed report of clinical characteristics recognized in EVALI cases with radiological findings of lung injury will not only provide a better understanding of the natural history of the disease, but also create a strong foundation for the development of evidence-based guidelines for the diagnosis, prognosis, and treatment of this condition. Here, we present data from a series of ten cases that recognize clinical characteristics in hospitalized EVALI patients with radiological findings of lung injury. Our ten-case series data recognized that clinical characteristics in hospitalized EVALI patients with radiological findings of lung injury, may include both respiratory and gastrointestinal or constitutional symptoms and based on the current literature may be misdiagnosed. E-cigarette or vaping product-use-associated lung injury (EVALI): A case report of a pneumonia mimic with severe leukocytosis and weight loss abstract: INTRODUCTION: Recently, a rapidly increasing number of e-cigarette or vaping induced lung injury (EVALI) has been reported across the nation. Given the ongoing epidemic, it has been suggested that specific chemical substances used as additives in e-cigarettes could be highly related to EVALI. A history of vaping with positive radiographic changes and low suspicion for active infection are requirements for diagnosis but it still remains a diagnosis of exclusion. The course of the disease, mechanism of lung injury and the optimal management options need to be better understood. Here we aimed to discuss the clinical characteristics recognized in a case series of ten hospitalized EVALI patients with radiological findings of lung injury and provide an up today summary of the known literature of EVALI-induced lung injury. METHODS: A retrospective chart review was conducted on ten patients who presented to Saint Peter’s University Hospital in New Brunswick, NJ from July 2019 to February 2020, with a mean hospital stay of five days. According to the CDC recommended definition of the disease, our cases met the current working definition of confirmed or probable cases of EVALI. RESULTS: Ten patients, with mean age 30.8 years (50 % male) and average years of vaping 1.708 with 60 % endorsing a simultaneous history of cannabis-related products use, went under a retrospective review. 3/10 (30 %) had documented medically-managed pulmonary disease history, 8/10 (80 %) presented with the respiratory-related chief complaint, 6/10 (60 %) presented with gastrointestinal symptoms and 7/10 (70 %) had constitutional symptoms. All patients (100 %) were found to have bilateral ground-glass opacities on chest imaging. 9/10 were admitted, 6/10 (60 %) had an oxygen saturation of <95 % requiring oxygen supplementation with 4/10 managed in the intensive care unit. CONCLUSION: EVALI patients with radiological findings of lung injury, although mainly present respiratory symptoms, may very often appear with constitutional and gastrointestinal symptoms. Based on the existing literature and our data it is argued that EVALI may be misdiagnosed and that closer monitoring is required to determine optimal diagnostic and therapeutic management of this condition. Our data and the existing literature suggest that laboratory and epidemiologic findings can be contributory for the diagnosis of the disease. url: https://www.ncbi.nlm.nih.gov/pubmed/33102141/ doi: 10.1016/j.toxrep.2020.09.010 id: cord-013589-3l8kar3k author: Doummar, Diane title: Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia date: 2020-05-28 words: 4136.0 sentences: 249.0 pages: flesch: 47.0 cache: ./cache/cord-013589-3l8kar3k.txt txt: ./txt/cord-013589-3l8kar3k.txt summary: A homozygous missense variant leading to drastic decrease of PDE2A enzymatic activity was reported in one patient with childhood-onset choreodystonia preceded by paroxysmal dyskinesia and associated with cognitive impairment and interictal EEG abnormalities. The phenotype of the two oldest patients, aged 9 and 26, was characterized by childhood-onset refractory paroxysmal dyskinesia initially misdiagnosed as epilepsy due to interictal EEG abnormalities. Together with previously reported case, our three patients confirm that biallelic PDE2A variants are a cause of childhood-onset refractory paroxysmal dyskinesia with cognitive impairment, sometimes associated with choreodystonia and interictal baseline EEG abnormalities or epilepsy. reported a missense homozygous variant in PDE2A in a patient with cognitive impairment, interictal EEG abnormalities, and childhoodonset chorea [8] . indicate that biallelic variants in PDE2A leading to loss of function are involved in heterogeneous phenotypes characterized by early-onset paroxysmal hyperkinetic movement disorders associated with cognitive impairment and possibly epilepsy. abstract: Cause of complex dyskinesia remains elusive in some patients. A homozygous missense variant leading to drastic decrease of PDE2A enzymatic activity was reported in one patient with childhood-onset choreodystonia preceded by paroxysmal dyskinesia and associated with cognitive impairment and interictal EEG abnormalities. Here, we report three new cases with biallelic PDE2A variants identified by trio whole-exome sequencing. Mitochondria network was analyzed after Mitotracker™ Red staining in control and mutated primary fibroblasts. Analysis of retrospective video of patients’ movement disorder and refinement of phenotype was carried out. We identified a homozygous gain of stop codon variant c.1180C>T; p.(Gln394*) in PDE2A in siblings and compound heterozygous variants in young adult: a missense c.446C>T; p.(Pro149Leu) and splice-site variant c.1922+5G>A predicted and shown to produce an out of frame transcript lacking exon 22. All three patients had cognitive impairment or developmental delay. The phenotype of the two oldest patients, aged 9 and 26, was characterized by childhood-onset refractory paroxysmal dyskinesia initially misdiagnosed as epilepsy due to interictal EEG abnormalities. The youngest patient showed a proven epilepsy at the age of 4 months and no paroxysmal dyskinesia at 15 months. Interestingly, analysis of the fibroblasts with the biallelic variants in PDE2A variants revealed mitochondria network morphology changes. Together with previously reported case, our three patients confirm that biallelic PDE2A variants are a cause of childhood-onset refractory paroxysmal dyskinesia with cognitive impairment, sometimes associated with choreodystonia and interictal baseline EEG abnormalities or epilepsy. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608189/ doi: 10.1038/s41431-020-0641-9 id: cord-339614-28s205p8 author: Dover, Jeffrey S. title: A Path to Resume Aesthetic Care: Executive Summary of Project AesCert Guidance Supplement—Practical Considerations for Aesthetic Medicine Professionals Supporting Clinic Preparedness in Response to the SARS-CoV-2 Outbreak date: 2020-05-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32374192/ doi: 10.1089/fpsam.2020.0239 id: cord-350959-bsbz3a1l author: Dovey, Zachary title: Impact of COVID-19 on Prostate Cancer Management: Guidelines for Urologists date: 2020-06-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Context The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a global health emergency, the like of which has never been seen before. Prostate cancer (PCa) services across the globe have been on hold due to changing medical and surgical priorities. There is also epidemiological evidence that PCa patients have increased incidence and mortality from SARS-CoV-2 infection due to gender differences, age, and higher propensity for risk factors (eg, respiratory disease, obesity, hypertension, and smoking status). Objective To contribute to the emerging body of knowledge on the risks of SARS-CoV-2 infection to PCa patients and, in the face of PCa treatment delays, provide evidence-based recommendations for ongoing management of specific PCa patient groups. Evidence acquisition A literature search was performed using all sources (MEDLINE, EMBASE, ScienceDirect, Cochrane Libraries, and Web of Science) as well as the media to harness emerging data on the SARS-CoV-2 pandemic and its influence on PCa. Eligibility criteria were originality of data and relevance to PCa management. The authors note that during these unprecedented times, retrospective data are constantly being updated from multiple sources globally. Evidence synthesis A total of 72 articles and data sources were found initially. Owing to repetition, lack of originality, or nonrelevance, six articles were rejected, leaving 23 retrospective studies, seven basic science research articles, 15 societal and journal guidelines, and 21 epidemiological data sources, from countries at different stages of SARS-CoV-2 pandemic. These were analyzed qualitatively to produce evidence-based guidelines for the management of PCa patients at different stages of the patient journey, with strategies to reduce the risk of viral spread. Conclusions PCa patients may have an increased risk of SARS-CoV-2 infection as well as morbidity and mortality if infected. Once appropriately triaged, and to reduce viral spread, PCa patients can have surveillance by telemedicine, and institute lifestyle changes and social quarantining measures. If risk stratification suggests that treatment should be planned, androgen deprivation therapy can be started, or potentially surgery or radiation therapy is possible on a case-by-case basis. Patient summary Prostate cancer patients can be followed up remotely until the severe acute respiratory syndrome coronavirus 2 pandemic resolves, but higher-risk cases may have treatment expedited to limit any negative impact on prostate cancer outcomes. url: https://www.sciencedirect.com/science/article/pii/S2666168320351120?v=s5 doi: 10.1016/j.euros.2020.05.005 id: cord-352889-fl61z3w3 author: Downs, John B. title: Proposal for Coronavirus Disease 2019 Management date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SETTING: The coronavirus disease 2019 pandemic has raised fear throughout the nation. Current news and social media predictions of ventilator, medication, and personnel shortages are rampant. PATIENTS: Patients with coronavirus disease 2019 are presenting with early respiratory distress and hypoxemia, but not hypercapnia. INTERVENTIONS: Patients who maintain adequate alveolar ventilation, normocapnia, and adequate oxygenation may avoid the need for tracheal intubation. Facemask continuous positive airway pressure has been used to treat patients with respiratory distress for decades, including those with severe acute respiratory syndrome. Of importance, protocols were successful in protecting caregivers from contracting the virus, obviating the need for tracheal intubation just to limit the spread of potentially infectious particles. CONCLUSIONS: During a pandemic, with limited resources, we should provide the safest and most effective care, while protecting caregivers. Continuous positive airway pressure titrated to an effective level and applied early with a facemask may spare ventilator usage. Allowing spontaneous ventilation will decrease the need for sedative and paralytic drugs and may decrease the need for highly skilled nurses and respiratory therapists. These goals can be accomplished with devices that are readily available and easier to obtain than mechanical ventilators, which then can be reserved for the sickest patients. url: https://doi.org/10.1097/cce.0000000000000127 doi: 10.1097/cce.0000000000000127 id: cord-348202-6we8e60b author: Drake, Daniel H. title: Echo in Pandemic: Front Line Perspective, Expanding Role of Ultrasound and Ethics of Resource Allocation date: 2020-04-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The grave clinical context of the pandemic must be understood. Italy is immersed in COVID-19. Most of the world will soon follow. The United States currently has the most documented cases of COVID-19 of any nation. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) associated acute cardiomyopathy is common in critical care patients and is associated with a high mortality. COVID-19 patients frequently require mechanical support for adequate oxygenation. A severe shortfall of ventilators is predicted. Of equal concern is the projected shortage of trained professionals required to care for patients on mechanical ventilation. Ultrasonography is proving to be a valuable tool for identifying the pulmonary manifestations and progression of COVID-19. Lung ultrasound also facilitates successful weaning from mechanical ventilation. Ultrasonography of the lung, pleura and diaphragm are easily mastered by experienced echocardiographers. Echocardiography has an established role for optimal fluid management and recognition of cardiac disease including SARS-CoV-2 associated acute cardiomyopathy. Cardiologists, anesthesiologists, sonographers, and all providers should be prepared to commit their full spectrum of skills to mitigate the consequences of the pandemic. We should also be prepared to collaborate and cross-train to expand professional services as necessary. During a declared health care crisis, providers must be familiar with the ethical principles, organizational structure, practical application, and gravity of limited resource allocation. url: https://www.sciencedirect.com/science/article/pii/S0894731720302182?v=s5 doi: 10.1016/j.echo.2020.04.007 id: cord-349280-12hc3mhq author: Drake, Justin A. title: Analysis of the Survival Impact of Postoperative Chemotherapy After Preoperative Chemotherapy and Resection for Gastric Cancer date: 2020-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Perioperative chemotherapy is a standard-of-care treatment for patients with gastric cancer. However, the impact of the postoperative chemotherapy (postCTX) component on overall survival (OS) is not well defined. METHODS: The National Cancer Database (NCDB) 2006–2014 was queried for patients who received preoperative chemotherapy (preCTX) and resection for gastric cancer. Analysis was performed to identify factors influencing receipt of postCTX. The impact of postCTX on OS was evaluated in propensity-matched groups. RESULTS: Among 3449 patients who received preCTX and resection for gastric cancer, 1091 (31.6%) received postCTX. Independent predictors of receiving postCTX were diagnosis after 2010 (odds ratio [OR] 1.985), distal tumor location (OR 1.348), and 15 or more lymph nodes examined (OR 1.214). Predictors of not receiving postCTX were older age (OR 0.985), comorbidity score higher than 1 (OR 0.592), and black race (OR 0.791). After propensity-matching (1091 per group), the median OS was 56.8 months for those who did receive postCTX versus 52.5 months for those who did not (p = 0.131). Subset analysis according to tumor grade, lymphovascular invasion, number of lymph nodes evaluated, T and N class, and AJCC stage identified an improvement in OS for the patients with N1 disease who received postCTX compared with those who did not (79.6 vs 41.3 months; p = 0.025). However, no other subgroup had a significant survival benefit. CONCLUSIONS: Additional postCTX was administered to a minority of patients who received preCTX and gastrectomy for gastric cancer, and its influence on OS appeared to be limited. Future trials should aim to define patients who will benefit from postCTX. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1245/s10434-020-09045-w) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1245/s10434-020-09045-w doi: 10.1245/s10434-020-09045-w id: cord-258416-1jrbu8ox author: Drenovska, Kossara title: Covid‐19 pandemic and the skin date: 2020-09-21 words: 1977.0 sentences: 121.0 pages: flesch: 40.0 cache: ./cache/cord-258416-1jrbu8ox.txt txt: ./txt/cord-258416-1jrbu8ox.txt summary: Following patients with psoriasis on biological therapy, as well as other inflammatory and autoimmune cutaneous disorders such as atopic dermatitis, pemphigus, pemphigoid diseases, and skin cancer provoked the interest of dermatologists. Here, we summarize skin conditions during the COVID‐19 pandemic, patient information, and expert recommendations and give an overview about the registries launched to document skin changes during COVID‐19, as well as details about certain patient groups infected with SARS‐CoV‐2, for example, psoriasis, atopic dermatitis, and autoimmune bullous diseases. 33 In a French prospective study on the incidence and types of COVID-19-associated cutaneous manifestations, skin involvement was reported in only 4.9% (five patients of 103) and presented as erythematous rash (two patients) and urticaria (two patients). Future case-controlled studies may potentially confirm AGA as a predictive factor for increased COVID-19 severity and contribute to the development of antiandrogen therapy for SARSNeonatal rashes Skin rashes in newborns of COVID-19-infected mothers were reported in two boys out of four infants from China. abstract: In the beginning of the COVID‐19 outbreak, skin manifestations, if present, were not paid enough attention. Then, the focus moved toward the impact of the prolonged use of personal protective measures in both healthcare workers and patients. In the meantime, attention is increasingly paid to dermatology as a result of the concern for certain groups of dermatologic patients, including those whose condition may worsen by the thorough disinfection measures and those treated with immunosuppressants or immunomodulators. Following patients with psoriasis on biological therapy, as well as other inflammatory and autoimmune cutaneous disorders such as atopic dermatitis, pemphigus, pemphigoid diseases, and skin cancer provoked the interest of dermatologists. Finally, an intriguing question to the dermatologic society was whether skin changes during COVID‐19 infection exist and what could be their diagnostic or prognostic value. Here, we summarize skin conditions during the COVID‐19 pandemic, patient information, and expert recommendations and give an overview about the registries launched to document skin changes during COVID‐19, as well as details about certain patient groups infected with SARS‐CoV‐2, for example, psoriasis, atopic dermatitis, and autoimmune bullous diseases. url: https://doi.org/10.1111/ijd.15189 doi: 10.1111/ijd.15189 id: cord-270210-gfy2ytg5 author: Drent, Marjolein title: Benefit of Wearing an Activity Tracker in Sarcoidosis date: 2020-08-22 words: 4444.0 sentences: 243.0 pages: flesch: 51.0 cache: ./cache/cord-270210-gfy2ytg5.txt txt: ./txt/cord-270210-gfy2ytg5.txt summary: The aim of this study was to estimate the effect of continuous activity monitoring using an electronic activity tracker (AT) on exercise performance and fatigue of sarcoidosis patients, compared to controls (cohort study), and the effect of additional personal coaching (randomized trial) over a period of 3 months. Exercise performance of patients wearing an AT (Group I) improved compared with controls (Group II), including the 6MWD, % predicted (∆4.4 ± 9.1 versus ∆0.7 ± 5.0, respectively), and fatigue levels decreased (∆−3.9 ± 5.7 versus ∆−1.8 ± 5.3). The aim of this study was to estimate (1) the potential effect of continuous activity monitoring using an electronic AT, compared with a historical control group in a cohort study and (2) the effect of additional personal coaching of sarcoidosis patients in a randomized trial. Wearing an AT in general, even without personal coaching by a physical therapist, improved exercise capacity and reduced fatigue in sarcoidosis patients. abstract: Sarcoidosis causes many disabling symptoms, including fatigue and exercise limitations, which have been shown to improve by physical activity programs. The aim of this study was to estimate the effect of continuous activity monitoring using an electronic activity tracker (AT) on exercise performance and fatigue of sarcoidosis patients, compared to controls (cohort study), and the effect of additional personal coaching (randomized trial) over a period of 3 months. Fifty-four sarcoidosis patients received an AT (Group Ia: 27 with coaching and Group Ib: 27 without). A historical group of sarcoidosis patients (Group II; n = 41) who did not follow a physical activity program served as controls. Exercise performance of patients wearing an AT (Group I) improved compared with controls (Group II), including the 6MWD, % predicted (∆4.4 ± 9.1 versus ∆0.7 ± 5.0, respectively), and fatigue levels decreased (∆−3.9 ± 5.7 versus ∆−1.8 ± 5.3). Patients with coaching (Group Ia) showed greater improvement of exercise capacity over time than patients without coaching (Group Ib) as shown by the Steep Ramp Test results (watts: ∆20.2 ± 33.8 versus ∆5.7 ± 26.4; and SRT, VO(2)max, % predicted: ∆1.6 ± 2.6 versus ∆0.7 ± 2.3). Sarcoidosis patients wearing an AT achieved improvement of exercise performance and reduction of fatigue. We therefore recommend encouraging sarcoidosis patients to wear an AT to stimulate physical activity and reduce fatigue. The additional benefit of coaching needs to be explored in future studies. url: https://doi.org/10.3390/jpm10030097 doi: 10.3390/jpm10030097 id: cord-005705-j765ruj1 author: Dreyfuss, Didier title: Is it better to consent to an RCT or to care?: Μηδεν αγαν (“nothing in excess”) date: 2004-12-17 words: 7508.0 sentences: 375.0 pages: flesch: 47.0 cache: ./cache/cord-005705-j765ruj1.txt txt: ./txt/cord-005705-j765ruj1.txt summary: Another contention of the present paper is this [14] : critical care physicians may still believe that RCTs remain the best tool for improving knowledge and care, and in this case they must accept to use the means needed to achieve the end and therefore to insist on mandatory informed consent from the patient or proxy; or they may realize that the game is not worth the candle and they must then turn to other forms of research that are ranked less highly in the pyramid of evidence-based medicine [15] . Before discussing the problem of informed consent to research a critical appraisal of the scientific and ethical validity of RCTs in critical care medicine is in order. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095248/ doi: 10.1007/s00134-004-2493-0 id: cord-279557-hk77e3pp author: Drosten, Christian title: Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection date: 2013-06-17 words: 4214.0 sentences: 243.0 pages: flesch: 55.0 cache: ./cache/cord-279557-hk77e3pp.txt txt: ./txt/cord-279557-hk77e3pp.txt summary: BACKGROUND: The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, Tunisia, Morocco, France, Italy, Germany, and the UK. [4] [5] [6] Here, we provide a full description of a fatal case of MERS-CoV infection imported to Munich, Germany, from Abu Dhabi, including a chronological profi le of virus concentrations in diverse body compartments. We subjected all available MERS-CoV genome sequences to phylogenetic analysis, including a correlation and regression analysis of known dates of virus isolation versus tree branch lengths (fi gure 3). Without quantitative laboratory data from well documented cases of MERS-CoV infection, most considerations had been made on the basis of an assumed analogy to severe acute respiratory syndrome (SARS). The recorded viral load profi le, with highest RNA concentrations in bronchoalveolar lavage and tracheobronchial aspirates, confi rms suggestions made in another report about the preferential use of lower-respiratory-tract samples for virus diagnostic tests. abstract: BACKGROUND: The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, Tunisia, Morocco, France, Italy, Germany, and the UK. We provide a full description of a fatal case of MERS-CoV infection and associated phylogenetic analyses. METHODS: We report data for a patient who was admitted to the Klinikum Schwabing (Munich, Germany) for severe acute respiratory infection. We did diagnostic RT-PCR and indirect immunofluorescence. From time of diagnosis, respiratory, faecal, and urine samples were obtained for virus quantification. We constructed a maximum likelihood tree of the five available complete MERS-CoV genomes. FINDINGS: A 73-year-old man from Abu Dhabi, United Arab Emirates, was transferred to Klinikum Schwabing on March 19, 2013, on day 11 of illness. He had been diagnosed with multiple myeloma in 2008, and had received several lines of treatment. The patient died on day 18, due to septic shock. MERS-CoV was detected in two samples of bronchoalveolar fluid. Viral loads were highest in samples from the lower respiratory tract (up to 1·2 × 10(6) copies per mL). Maximum virus concentration in urine samples was 2691 RNA copies per mL on day 13; the virus was not present in the urine after renal failure on day 14. Stool samples obtained on days 12 and 16 contained the virus, with up to 1031 RNA copies per g (close to the lowest detection limit of the assay). One of two oronasal swabs obtained on day 16 were positive, but yielded little viral RNA (5370 copies per mL). No virus was detected in blood. The full virus genome was combined with four other available full genome sequences in a maximum likelihood phylogeny, correlating branch lengths with dates of isolation. The time of the common ancestor was halfway through 2011. Addition of novel genome data from an unlinked case treated 6 months previously in Essen, Germany, showed a clustering of viruses derived from Qatar and the United Arab Emirates. INTERPRETATION: We have provided the first complete viral load profile in a case of MERS-CoV infection. MERS-CoV might have shedding patterns that are different from those of severe acute respiratory syndrome and so might need alternative diagnostic approaches. FUNDING: European Union; German Centre for Infection Research; German Research Council; and German Ministry for Education and Research. url: https://doi.org/10.1016/s1473-3099(13)70154-3 doi: 10.1016/s1473-3099(13)70154-3 id: cord-297327-19dfgfz6 author: Drożdżal, Sylwester title: COVID-19: Pain Management in Patients with SARS-CoV-2 Infection—Molecular Mechanisms, Challenges, and Perspectives date: 2020-07-20 words: 5672.0 sentences: 319.0 pages: flesch: 41.0 cache: ./cache/cord-297327-19dfgfz6.txt txt: ./txt/cord-297327-19dfgfz6.txt summary: Many patients with SARS-CoV-2 infection will suffer from severe pain and require reliable pain assessment to provide adequate analgesia, often with multiple drugs, including opioids, nonPutative mechanisms of myalgia and headache during viral infection. Many patients with SARS-CoV-2 infection will suffer from severe pain and require reliable pain assessment to provide adequate analgesia, often with multiple drugs, including opioids, non-steroidal inflammatory drugs or analgosedation [52] . Recently, concerns about the possible higher frequency of adverse effects and exacerbation of symptoms of viral respiratory tract infections, such as COVID-19, in patients treated with NSAIDs have been raised [67] . There are reports of a significantly higher use of opioids because of sedation requirements during respiratory failure caused by SARS-CoV-2, which highlights the importance of undertaking a study aiming to determine efficacious and safe procedures of pain management in patients with COVID-19. abstract: Since the end of 2019, the whole world has been struggling with the pandemic of the new Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Available evidence suggests that pain is a common symptom during Coronavirus Disease 2019 (COVID-19). According to the World Health Organization, many patients suffer from muscle pain (myalgia) and/or joint pain (arthralgia), sore throat and headache. The exact mechanisms of headache and myalgia during viral infection are still unknown. Moreover, many patients with respiratory failure get admitted to the intensive care unit (ICU) for ventilatory support. Pain in ICU patients can be associated with viral disease itself (myalgia, arthralgia, peripheral neuropathies), may be caused by continuous pain and discomfort associated with ICU treatment, intermittent procedural pain and chronic pain present before admission to the ICU. Undertreatment of pain, especially when sedation and neuromuscular blocking agents are used, prone positioning during mechanical ventilation or extracorporeal membrane oxygenation (ECMO) may trigger delirium and cause peripheral neuropathies. This narrative review summarizes current knowledge regarding challenges associated with pain assessment and management in COVID-19 patients. A structured prospective evaluation should be undertaken to analyze the probability, severity, sources and adequate treatment of pain in patients with COVID-19 infection. url: https://doi.org/10.3390/brainsci10070465 doi: 10.3390/brainsci10070465 id: cord-029150-e242o2ml author: Du, Jiang title: Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic date: 2020-07-08 words: 4256.0 sentences: 187.0 pages: flesch: 32.0 cache: ./cache/cord-029150-e242o2ml.txt txt: ./txt/cord-029150-e242o2ml.txt summary: In early 2020, the COVID-19 outbreak complicated the diagnosis, treatment and rehabilitation of patients with substance use disorders and increased the risks of substance abuse and addictive behaviours, such as online gaming disorders, in the general public. It also adversely impacts the mental state of the general public in several ways and leads to broader symptoms, including anxiety, tension and insomnia, that may increase the risk of alcohol abuse, sedative and hypnotic drug abuse, and other addictive behaviours. 2 3 It is also of utmost importance to ensure the continuous, regular and effective treatment of existing patients with addiction problems, reduce the risk of drug relapse and prevent new cases of addiction during the pandemic. The screening of addictive substance use, prevention and education for clinic patients, as well as the timely identification, diagnosis and treatment of related mental and behavioural problems may all occur under stressful conditions. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358097/ doi: 10.1136/gpsych-2020-100252 id: cord-318311-aakpbbvl author: Du, Na title: The experience of prevention measures taken by the psychiatric hospital during the emergence of asymptomatic patients with COVID-19 date: 2020-05-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0165178120313056?v=s5 doi: 10.1016/j.psychres.2020.113109 id: cord-321768-oevswvvd author: Duan, Ya-qi title: Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease. Understanding the dysregulated human immune responses in the fatal subjects is critical for management of COVID-19 patients and the pandemic. In this study, we examined the immune cell compositions in the lung tissues and hilar lymph nodes using immunohistochemistry on 6 deceased COVID-19 patients and 4 focal organizing pneumonia (FOP) patients who underwent lung surgery and served as controls. We found a dominant presence of macrophages and a general deficiency of T cells and B cells in the lung tissues from deceased COVID-19 patients. In contrast to the FOP patients, Tfh cells and germinal center formation were largely absent in the draining hilar lymph nodes in the deceased COVID-19 patients. This was correlated with reduced IgM and IgG levels compared to convalescent COVID-19 patients. In summary, our data highlight a defect of germinal center structure in deceased COVID-19 patients leading to an impaired humoral immunity. Understanding the mechanisms of this deficiency will be one of the key points for the management of this epidemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32767259/ doi: 10.1007/s11596-020-2225-x id: cord-345517-ji4cet51 author: Duarte de Araújo, António Manuel Silva title: Copd: will there be room for nebulisers after the current covid-19 pandemic? date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2659663620300655?v=s5 doi: 10.1016/j.opresp.2020.08.001 id: cord-294108-uvnh0s9r author: Dube, Taru title: Repurposed Drugs, Molecular Vaccines, Immune‐Modulators, and Nanotherapeutics to Treat and Prevent COVID‐19 Associated with SARS‐CoV‐2, a Deadly Nanovector date: 2020-10-25 words: 13885.0 sentences: 845.0 pages: flesch: 44.0 cache: ./cache/cord-294108-uvnh0s9r.txt txt: ./txt/cord-294108-uvnh0s9r.txt summary: [2, [8] [9] [10] This article discusses SARS-CoV-2 nanostructure, the virus biology in connection to its epidemiology, clinical manifestations, and potential and future therapeutic options including repurposed drugs, vaccine/protein therapies, immune therapies, and nanotherapeutics. Mechanisms such as inhibition of viral enzymes (DNA and RNA polymerases, 3CL pro, TMPRSS2, reverse transcriptase, neuraminidase, endonucleases, and other proteases) or processes such as ACE2 cellular receptor inhibitors and endosomal acidification mediators prohibiting viral fusion; molecules interfering with glycosylation of the viral protein, viral assembly, new viral particle transport, and release, and immunomodulation of cytokine release can be potential targets in developing various antiviral drugs for the SARS-CoV-2. [85] A randomized, placebo-controlled, Phase IV clinical trial assessing the safety and efficacy of umifenovir as an adjuvant therapy to the combined therapeutic regimen of IFN 1a, lopinavir/ritonavir and hydroxychloroquine in moderate to severe COVID-19 patients (NCT04350684) is underway. abstract: The deadly pandemic, coronavirus disease 2019 (COVID‐19), caused due to the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has paralyzed the world. Although significant methodological advances have been made in the field of viral detection/diagnosis with 251 in vitro diagnostic tests receiving emergency use approval by the US‐FDA, little progress has been made in identifying curative or preventive therapies. This review discusses the current trends and potential future approaches for developing COVID‐19 therapeutics, including repurposed drugs, vaccine candidates, immune‐modulators, convalescent plasma therapy, and antiviral nanoparticles/nanovaccines/combinatorial nanotherapeutics to surmount the pandemic viral strain. Many potent therapeutic candidates emerging via drug‐repurposing could significantly reduce the cost and duration of anti‐COVID‐19 drug development. Gene/protein‐based vaccine candidates that could elicit both humoral and cell‐based immunity would be on the frontlines to prevent the disease. Many emerging nanotechnology‐based interventions will be critical in the fight against the deadly virus by facilitating early detection and enabling target oriented multidrug therapeutics. The therapeutic candidates discussed in this article include remdesivir, dexamethasone, hydroxychloroquine, favilavir, lopinavir/ritonavir, antibody therapeutics like gimsilumab and TJM2, anti‐viral nanoparticles, and nanoparticle‐based DNA and mRNA vaccines. url: https://doi.org/10.1002/adtp.202000172 doi: 10.1002/adtp.202000172 id: cord-257504-tqzvdssb author: Dubost, Clément title: Preparation of an intensive care unit in France for the reception of a confirmed case of Ebola virus infection() date: 2015-11-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The current Ebola Virus Disease (EVD) outbreak in West Africa is a major challenge for the worldwide medical community. On April 29th 2015, the World Health Organization (WHO) declared 26,277 infected cases; among them, 10,884 have deceased. The epidemic is still ongoing, particularly in Sierra Leone. It is now clear that northern countries will be implicated in the care of EVD patients, both in the field and back at home. Because of the severity of EVD, a fair amount of patients may require intensive care. It is highly probable that intensive care would be able to significantly reduce the mortality linked with EVD. The preparation of a modern Intensive Care Unit (ICU) to treat an EVD patient in good conditions requires time and specific equipment. The cornerstone of this preparation includes two main goals: treating the patient and protecting healthcare providers. Staff training is time consuming and must be performed far in advance of patient arrival. To be efficient, preparation should be planned at a national level with help from public authorities, as was the case in France during the summer of 2014. Due to the severity of the disease, the high risk of transmission and scarce knowledge on EVD treatment, our propositions are necessarily original and innovative. Our review includes four topics: a brief report on the actual outbreak, where to receive and hospitalize the patients, the specific organization of the ICU and finally ethical aspects. url: https://doi.org/10.1016/j.accpm.2015.10.002 doi: 10.1016/j.accpm.2015.10.002 id: cord-287786-zfe0el8i author: Dudoignon, Emmanuel title: Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19 date: 2020-06-18 words: 1011.0 sentences: 69.0 pages: flesch: 49.0 cache: ./cache/cord-287786-zfe0el8i.txt txt: ./txt/cord-287786-zfe0el8i.txt summary: title: Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19 Abstract The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. Characterisation and understanding of COVID-19 renal injury would improve the management of patients admitted to the intensive care unit (ICU). Here, we describe the renal response of patients with COVID-19 patients admitted to an intensive care unit (ICU), with a particular focus on the activation of the renin-angiotensin-aldosterone system. Patients admitted to the ICU of St-Louis Hospital (Paris) between March 22 and April 15, 2020 for acute respiratory distress syndrome (Berlin Definition [7] ) with acute kidney injury (AKI, defined according to the Kidney Disease-Improving Global Outcome criteria [8] and using the admission serum creatinine as the baseline) were screened. Patients with AKI showed direct (increased plasma renin and aldosterone concentration) and indirect (low urine sodium concentration) markers of activation of the RAAS [3] . abstract: Abstract The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. SARS-CoV2 has been suggested to modulate the renin-angiotensin-aldosterone system (RAAS). In this series of COVID-19 critically ill patients, we report evidence of activation of the RAAS in COVID-19 patients with AKI. url: https://doi.org/10.1016/j.accpm.2020.06.006 doi: 10.1016/j.accpm.2020.06.006 id: cord-287558-yc8aw2pg author: Duffy, Eamon Y. title: Primary and Secondary Prevention of Cardiovascular Disease in the Era of the Coronavirus Pandemic date: 2020-04-20 words: 707.0 sentences: 41.0 pages: flesch: 38.0 cache: ./cache/cord-287558-yc8aw2pg.txt txt: ./txt/cord-287558-yc8aw2pg.txt summary: Telemedicine and remote monitoring will make it easier to frequently reach patients to optimize risk factor control, titrate medications, assess diets and physical activity levels, and integrate reminders to meet daily goals, among other capabilities. Besides health implications, the economic effect of the COVID-19 pandemic will be enormous and preventive cardiologists will need to adapt to a landscape of potential economic recession, with some patients facing financial hardship. The same will be true for research on patient-and context-level determinants associated with adverse cardiovascular outcomes during lockdowns and on opportunities to improve these. Marked advances in telemedicine in the post-COVID-19 era will provide an opportunity to enhance the care of primary and secondary prevention patients, with implications not only for CVD outcomes but also for reducing the burden of complications and deaths in current and future viral outbreaks. abstract: nan url: https://doi.org/10.1161/circulationaha.120.047194 doi: 10.1161/circulationaha.120.047194 id: cord-297138-t8b3914h author: Duijker, G. title: Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection: Results from a double-blind randomized controlled trial date: 2015-04-02 words: 6832.0 sentences: 325.0 pages: flesch: 49.0 cache: ./cache/cord-297138-t8b3914h.txt txt: ./txt/cord-297138-t8b3914h.txt summary: Conclusions Compared with placebo the essential-oil extract of three Cretan aromatic plants provided no detectable statistically significant benefit or harm in the patients with upper respiratory illness, although descriptive differences were identified in favorable direction mainly in the virus-positive population. As stated above, this study reports the results of the effectiveness of an extract based on three Cretan aromatic plants in the reduction of duration and severity of symptoms of patients with upper respiratory tract infections, utilizing a standardized questionnaire, physical examination measurements and the decrease of inflammation assayed by C-reactive protein [CRP] levels. Severity of symptoms over the study period was compared between intervention and control groups, using the 19-item WURSS-21 scores, with both univariate techniques and multiple linear regression models, adjusting for age, sex, initial CRP level, body mass index (BMI) and the presence of chronic diseases. abstract: Abstract Ethnopharmacological relevance Observations from the island of Crete, Greece suggest that infusions of traditional Cretan aromatic plants, well known for their ethnopharmacological use in Eastern Mediterranean region and Near East, could be effective in the prevention and treatment of upper respiratory tract infections, including viral-induced infections. The aim of this study was to report the effectiveness of an essential-oil extract of three Cretan aromatic plants in the treatment of cases with an upper respiratory tract infection. Materials and methods A double blind randomized controlled trial was implemented between October 2013 and February 2014. An essential-oil extract of Cretan aromatic plants in olive oil (total volume of 15ml of essential oil per litre of olive oil) was administered as 0.5ml soft gel capsules, twice a day, for 7 days. Placebo treatment was 0.5ml olive oil in soft gel capsules. Eligible patients were those presenting for clinical examination in the selected setting with signs and symptoms of upper respiratory tract infection that had begun within the previous 24hours. Real-Time Polymerase Chain Reaction (PCR) was used for the detection of respiratory viruses. The primary outcome was the severity and duration of symptoms of upper respiratory tract infection, assessed using the Wisconsin Upper Respiratory System Survey (WURSS-21) questionnaire. A secondary outcome of interest was the change in C-reactive protein (CRP) status. Results One hundred and five patients completed the study: 51 in the placebo group, and 54 in the intervention (treated) group. Baseline characteristics were similar in the two groups. No statistically significant differences were found in symptom duration or severity between the two groups, although small and clinically favorable effects were observed. When the analysis was restricted to subjects with a laboratory-documented viral infection, the percentage of patients with cessation of symptoms after 6 days of treatment was 91% in the intervention group and 70% in the control group (p=0.089). At baseline, one third of the patients in each group had elevated CRP levels. At follow-up, the respective proportions were 0% in the intervention group and 15% in the placebo group (p=0.121). The data were also in a favorable direction when 50% and 80% symptom reduction points were considered for specific virus types. Conclusions Compared with placebo the essential-oil extract of three Cretan aromatic plants provided no detectable statistically significant benefit or harm in the patients with upper respiratory illness, although descriptive differences were identified in favorable direction mainly in the virus-positive population. url: https://doi.org/10.1016/j.jep.2015.01.030 doi: 10.1016/j.jep.2015.01.030 id: cord-294700-pb5k21da author: Dulek, Daniel E title: Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute COVID-19 in Pediatric Patients date: 2020-08-18 words: 14522.0 sentences: 835.0 pages: flesch: 38.0 cache: ./cache/cord-294700-pb5k21da.txt txt: ./txt/cord-294700-pb5k21da.txt summary: Although the majority of SARS-CoV-2 infections in pediatric populations result in minimal or mild COVID-19 in the acute phase of infection, a small subset of children develop severe and even critical disease in this phase with concomitant inflammation that may benefit from immunomodulation. The framework presented herein offers an approach to decision-making regarding immunomodulatory therapy for severe or critical pediatric COVID-19 and is informed by currently available data, while awaiting results of placebo-controlled randomized clinical trials. Given the lack of available results from randomized-controlled trials of immunomodulatory therapy in children with COVID-19, the risk-benefit ratio for most pediatric patients points toward supportive care as the key management strategy. In the absence of such opportunity, and recognizing that definitive evidence is lacking, consideration for use of immunomodulatory agents in cases of SARS-CoV-2 infection with clinical and biochemical evidence of cytokine storm physiology (e.g., features of secondary HLH) should be limited to patients with clear evidence of critical COVID-19 disease and risk for multi-organ failure. abstract: BACKGROUND: Immune-mediated lung injury and systemic hyperinflammation are characteristic of severe and critical coronavirus disease 2019 (COVID-19) in adults. Although the majority of SARS-CoV-2 infections in pediatric populations result in minimal or mild COVID-19 in the acute phase of infection, a small subset of children develop severe and even critical disease in this phase with concomitant inflammation that may benefit from immunomodulation. Therefore, guidance is needed regarding immunomodulatory therapies in the setting of acute pediatric COVID-19. This document does not provide guidance regarding the recently emergent multisystem inflammatory syndrome in children (MIS-C). METHODS: A multidisciplinary panel of pediatric subspecialty physicians and pharmacists with expertise in infectious diseases, rheumatology, hematology/oncology, and critical care medicine was convened. Guidance statements were developed based on best available evidence and expert opinion. RESULTS: The panel devised a framework for considering the use of immunomodulatory therapy based on an assessment of clinical disease severity and degree of multi-organ involvement combined with evidence of hyperinflammation. Additionally, the known rationale for consideration of each immunomodulatory approach and the associated risks and benefits was summarized. CONCLUSIONS: Immunomodulatory therapy is not recommended for the majority of pediatric patients, who typically develop mild or moderate COVID-19. For children with severe or critical illness, the use of immunomodulatory agents may be beneficial. The risks and benefits of such therapies are variable and should be evaluated on a case-by-case basis with input from appropriate specialty services. When available, the panel strongly favors immunomodulatory agent use within the context of clinical trials. The framework presented herein offers an approach to decision-making regarding immunomodulatory therapy for severe or critical pediatric COVID-19 and is informed by currently available data, while awaiting results of placebo-controlled randomized clinical trials. url: https://www.ncbi.nlm.nih.gov/pubmed/32808988/ doi: 10.1093/jpids/piaa098 id: cord-269105-yuphgyrn author: Dumantepe, Mert title: Subsegmental Thrombus in COVID-19 Pneumonia: Immunothrombosis or Pulmonary Embolism? Data Analysis of Hospitalised Patients With Coronavirus Disease date: 2020-08-24 words: 1324.0 sentences: 81.0 pages: flesch: 38.0 cache: ./cache/cord-269105-yuphgyrn.txt txt: ./txt/cord-269105-yuphgyrn.txt summary: Thrombotic complications due to considerable inflammation, cytokine-mediated microvascular damage and pulmonary immunothrombosis formation seem to have emerged as an important issue in people infected with COVID-19. Cytokine-mediated microvascular damage, hypoxia, systemic inflammation, microangiopathy, coagulation pathway activation, and eventual immunothrombosis development have been described as key features of severe COVID-19 [4] . COVID-19 infection is related with high morbidity and mortality, mainly due to respiratory failure, with microvascular hyaline membrane and pulmonary immunothrombosis formation presumably playing a crucial role. In patients with COVID-19 pneumonia, presenting with disease progression or worsening of respiratory symptoms and significant elevation of D-Dimer levels, more attention should be paid to the occurrence of potential pulmonary embolism (PE) with or without deep venous thrombosis (DVT). During the study period, four COVID-19 pneumonia patients in conjunction with high-risk PE were treated with EKOS ™ Acoustic Pulse Thrombolysis ( [11] . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China abstract: Background The new coronavirus disease (SARS-CoV-2) has caused more than 350,000 deaths worldwide. Thrombotic complications due to considerable inflammation, cytokine-mediated microvascular damage and pulmonary immunothrombosis formation seem to have emerged as an important issue in people infected with COVID-19. Methods This study reviewed consecutive symptomatic patients with proven COVID-19 infection admitted to Acibadem University Hospital in Istanbul, Turkey (15 March–25 May 2020). The primary outcome was any venous thromboembolic (VTE) complication. The secondary outcome was the incidence of subsegmental pulmonary embolism with or without deep vein thrombosis (DVT), which represented immunothrombosis development. Results The mean age was 55.7±17.4 years (range, 29–84); 224 (63.6%) were men. Of those patients, 12 (3.4%) died, 273 (77.5%) were discharged alive and 67 (19.1%) were still hospitalised as of 25 May 2020. VTE events occurred in 58 patients with a cumulative rate of 16.4% during the study period. The surprising discovery was that DVT was not identified in 20 (86.9%) of the 23 patients with subsegmental pulmonary embolism, which corroborated the pulmonary immunothrombosis theory. Conclusions The high incidence of VTE events suggests an important role of COVID-19-induced coagulopathy. Thus, repeated assessment and optimised treatment are necessary to reduce the occurrence of VTE and prevent fatal pulmonary embolism events. Further studies are needed to investigate the molecular mechanism of this immunothrombosis development. url: https://doi.org/10.1016/j.hlc.2020.08.003 doi: 10.1016/j.hlc.2020.08.003 id: cord-290081-pjg00t7g author: Dunkerley, Sarah title: Patient care modifications and hospital regulations during the COVID-19 crisis created inequality and functional hazard for patients with orthopaedic trauma date: 2020-08-07 words: 2921.0 sentences: 183.0 pages: flesch: 56.0 cache: ./cache/cord-290081-pjg00t7g.txt txt: ./txt/cord-290081-pjg00t7g.txt summary: PURPOSE: The COVID pandemic has decreased orthopaedic fracture operative intervention and follow-up and increased the use of virtual telemedicine clinics. We surveyed 100 virtual fracture clinic follow-up patients for satisfaction, time off work and travel. New virtual follow-up fracture clinics reduced patient face-to-face appointments. All the patients brought into hospital were ''normal'' decisions and all those in the virtual fracture clinic review clinic were ''COVID'' due to lack of normal face-to-face interaction. The PIFU patients were subdivided into 3 groups: ''normal'' decisions, ''COVID'' decisions based on lack of clinical review or follow-up, and ''COVID'' decisions based on potential mal-unions (see Fig. 1 ). Of the 11 patients who were brought back for a face-to-face follow-up, five were due to future appointments to have a cast removed and six were due to the clinician deciding they needed a clinical assessment in hospital (thus a repeat appointment). abstract: PURPOSE: The COVID pandemic has decreased orthopaedic fracture operative intervention and follow-up and increased the use of virtual telemedicine clinics. We assessed the implications of this management on future orthopaedic practice. We also surveyed patient satisfaction of our virtual fracture follow-up clinics. METHOD: We prospectively analysed 154 patients during two weeks of ‘lockdown’ assessing their management. We surveyed 100 virtual fracture clinic follow-up patients for satisfaction, time off work and travel. RESULTS: Forty-nine percent of patients had decisions affected by COVID. Twelve percent of patients were discharged at diagnosis having potentially unstable fractures. These were all upper limb fractures which may go onto mal-union. Twenty-nine percent of patients were discharged who would have normally had clinal or radiological follow-up. No patients had any long-term union follow-up. Virtual telemedicine clinics have been incredibly successful. The average satisfaction was 4.8/5. In only 6% of cases, the clinician felt a further face-to-face evaluation was required. Eighty-nine percent of patients would have chosen virtual follow-up under normal conditions. CONCLUSION: Lessons for the future include potentially large numbers of upper limb mal-unions which may be symptomatic. The non-union rate is likely to be the same, but these patients are unknown due to lack of late imaging. Telemedicine certainly has a role in future orthopaedic management as it is well tolerated and efficient and provides economic and environmental benefits to both clinicians and patients. url: https://doi.org/10.1007/s00264-020-04764-x doi: 10.1007/s00264-020-04764-x id: cord-327481-m9r0p84v author: Duployez, Nicolas title: Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19 date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Advanced age or preexisting comorbidities have been characterized as risk factors for severe coronavirus disease 2019 (COVID-19) cases requiring hospitalization and intensive care. In recent years, clonal hematopoiesis (CH) of indeterminate potential (CHIP) has emerged as a risk factor for chronic inflammatory background and subsequent aging-associated diseases. The purpose of this study was to identify biological factors (particularly leukocyte subtypes and inflammatory markers) associated with a risk of clinical deterioration (i.e., orotracheal intubation (OTI)) and to determine whether CH was likely to influence clinical and biological behavior in patients with severe COVID-19 requiring hospitalization. Here, we describe clinical and biological features, including the screening of CHIP mutants in a well-annotated cohort of 122 hospitalized patients with a laboratory-confirmed diagnosis of COVID-19 (55% requiring OTI). We showed that elevated white blood cell counts, especially neutrophils and high C-reactive protein (CRP) levels at admission, were associated with an increased requirement of OTI. We noticed a high prevalence of CH (25%, 38%, 56%, and 82% of patients aged <60 years, 60–70 years, 70–80 years, and >80 years) compared to a retrospective cohort of patients free of hematological malignancy explored with the same pipelines (10%, 21%, 37%, and 44%). However, the existence of CH did not significantly impact clinical outcome, including OTI or death, and did not correlate with other laboratory findings. url: https://doi.org/10.3390/cancers12071992 doi: 10.3390/cancers12071992 id: cord-017883-6a4fkd5v author: Dutta, Ankhi title: Infection Prevention in Pediatric Oncology and Hematopoietic Stem Cell Transplant Recipients date: 2018-07-16 words: 6243.0 sentences: 301.0 pages: flesch: 35.0 cache: ./cache/cord-017883-6a4fkd5v.txt txt: ./txt/cord-017883-6a4fkd5v.txt summary: There are various factors which contribute to the increased susceptibility to infections in pediatric hematology/oncology (PHO) and HSCT patients, most prominent of them being disruption of cutaneous and mucosal barriers (oral, gastrointestinal, etc.), microbial gastrointestinal translocation, defects in cell-mediated immunity, and insufficient quantities and inadequate function of phagocytes. Based upon such data in adults, the IDSA Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer state that fluoroquinolone prophylaxis should be considered for high-risk patients with prolonged severe neutropenia [20] . Though some authors suggest that antibiotic prophylaxis should be considered in children undergoing induction chemotherapy for ALL, there is currently insufficient data to inform definitive guidelines for antibiotic prophylaxis to prevent bacterial infections in pediatric oncology patients [19] [20] [21] . abstract: Pediatric patients with malignancies and transplant recipients are at high risk of infection-related morbidity and mortality. Children at the highest risk for infections are those with acute myeloid leukemia (AML), relapsed acute lymphoblastic leukemia (ALL), and hematopoietic stem cell transplant recipients (HSCT). These patients are at high risk for life-threatening bacterial, viral, and fungal infections which are associated with prolonged hospital stay, poor quality of life, and increased healthcare cost and death. Recognition of risk factors which predisposes them to infections, early identification of signs and symptoms of infections, prompt diagnosis, and empiric/definitive treatment are the mainstay in reducing infection-related morbidity and mortality. Infection control and prevention programs also play a crucial role in preventing hospital-acquired infections in these immunosuppressed hosts. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122566/ doi: 10.1007/978-3-319-98122-2_16 id: cord-010116-hfzs16jh author: Díaz‐Ravetllat, V. title: Significance of new lung infiltrates in outpatients after lung and heart–lung transplantation date: 2014-04-12 words: 4254.0 sentences: 256.0 pages: flesch: 40.0 cache: ./cache/cord-010116-hfzs16jh.txt txt: ./txt/cord-010116-hfzs16jh.txt summary: Other causes of pulmonary infiltrates include acute cellular rejection, chronic lung allograft dysfunction Abbreviations: AR, acute rejection; BAL, bronchoalveolar lavage; BOS, bronchiolitis obliterans syndrome; CFU, colony-forming units; CLAD, chronic lung allograft dysfunction; CMV, cytomegalovirus; CRP, C-reactive protein; FEV1, forced expiratory volume in the first second; IQR, interquartile range; ISHLT, International Society of Heart and Lung Transplantation; LTR, lung transplant recipients; LTx, lung transplantation; SOT, solid organ transplant; TBB, transbronchial biopsy (CLAD), and drug toxicity. Patients A retrospective analysis was performed of all LTR and heart-lung transplant recipients attending the outpatient clinic at our institution between September 1, 2006 and October 14, 2011. Pulmonary infiltrates on postoperative chest x-rays are common in lung vascular injury of the donor, re-implantation disease (24) , reperfusion edema (25), or primary graft dysfunction (26) , vascular obstruction, adult respiratory distress syndrome (27) , infection, atelectasis (26) , rejection, pharmacological toxicity, and post-transplantation lymphoproliferative disorders (28) . abstract: BACKGROUND: Infection and rejection represent major complications following lung transplantation and are often associated with pulmonary infiltrates. The differential diagnosis of these infiltrates depends on their timing after transplantation. The aim of this study was to characterize lung transplant recipients (LTR) presenting with new pulmonary infiltrates. METHODS: A retrospective analysis of all LTR and heart–lung transplant recipients attending outpatient follow‐up at our institution between September 1, 2006 and October 14, 2011 was performed. All patients presenting with new pulmonary infiltrates on chest x‐ray who underwent bronchoscopy were included. RESULTS: A total of 913 patients accounted for 13,156 attendances, with 3,912 bronchoscopies being performed. Seventy‐eight patients (9%) exhibited new pulmonary infiltrates and proceeded to bronchoscopy. Infiltrates occurred at a median 15 (interquartile range [IQR] 5–39) months after transplantation. Forty‐eight patients (62%) were male, and median patient age was 47 (IQR 29–57) years. Subsequent investigation revealed pneumonia to be the underlying cause in 63 patients (81%). In the remaining patients, chronic lung allograft dysfunction (CLAD) was responsible in 6 (8%), acute rejection in 5 (6%), and toxic pneumonitis in 4 (5%) patients. Overall 1‐year survival in LTR presenting with new infiltrates was 97%, compared with 96% for all LTR attending our Outpatient Department. CONCLUSIONS: New pulmonary infiltrates occurring after the first month in LTR are most likely due to infection. Through prompt diagnosis and treatment, early mortality appears unaffected. Late mortality remains attributable to CLAD. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169667/ doi: 10.1111/tid.12209 id: cord-328113-eczjjc2v author: D’Alessandro, Angelo title: Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level date: 2020-07-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: [Image: see text] Over 5 million people around the world have tested positive for the beta coronavirus SARS-CoV-2 as of May 29, 2020, a third of which are in the United States alone. These infections are associated with the development of a disease known as COVID-19, which is characterized by several symptoms, including persistent dry cough, shortness of breath, chills, muscle pain, headache, loss of taste or smell, and gastrointestinal distress. COVID-19 has been characterized by elevated mortality (over 100 thousand people have already died in the US alone), mostly due to thromboinflammatory complications that impair lung perfusion and systemic oxygenation in the most severe cases. While the levels of pro-inflammatory cytokines such as interleukin-6 (IL-6) have been associated with the severity of the disease, little is known about the impact of IL-6 levels on the proteome of COVID-19 patients. The present study provides the first proteomics analysis of sera from COVID-19 patients, stratified by circulating levels of IL-6, and correlated to markers of inflammation and renal function. As a function of IL-6 levels, we identified significant dysregulation in serum levels of various coagulation factors, accompanied by increased levels of antifibrinolytic components, including several serine protease inhibitors (SERPINs). These were accompanied by up-regulation of the complement cascade and antimicrobial enzymes, especially in subjects with the highest levels of IL-6, which is consistent with an exacerbation of the acute phase response in these subjects. Although our results are observational, they highlight a clear increase in the levels of inhibitory components of the fibrinolytic cascade in severe COVID-19 disease, providing potential clues related to the etiology of coagulopathic complications in COVID-19 and paving the way for potential therapeutic interventions, such as the use of pro-fibrinolytic agents. Raw data for this study are available through ProteomeXchange with identifier PXD020601. url: https://doi.org/10.1021/acs.jproteome.0c00365 doi: 10.1021/acs.jproteome.0c00365 id: cord-340253-lpner9f8 author: D’Amario, Domenico title: Sex-Related Differences in Dilated Cardiomyopathy with a Focus on Cardiac Dysfunction in Oncology date: 2020-08-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: The aim of this report is to describe the main aspects of sex-related differences in non-ischemic dilated cardiomyopathies (DCM), focusing on chemotherapy-induced heart failure (HF) and investigating the possible therapeutic implications and clinical management applications in the era of personalized medicine. RECENT FINDINGS: In cardio-oncology, molecular and multimodality imaging studies confirm that sex differences do exist, affecting the therapeutic cardioprotective strategies and, therefore, the long-term outcomes. Interestingly, compelling evidences suggest that sex-specific characteristics in drug toxicity might predict differences in the therapeutic response, most likely due to the tangled interplay between cancer and HF, which probably share common underlying mechanisms. SUMMARY: Cardiovascular diseases show many sex-related differences in prevalence, etiology, phenotype expression, and outcomes. Complex molecular mechanisms underlie this diverse pathological manifestations, from sex-determined differential gene expression to sex hormone interaction with their receptors in the heart. Non-ischemic DCM is an umbrella definition that incorporates several etiologies, including chemotherapy-induced cardiomyopathies. The role of sex as a risk factor for cardiotoxicity is poorly explored. However, understanding the various features of disease manifestation and outcomes is of paramount importance for a prompt and tailored evaluation. url: https://www.ncbi.nlm.nih.gov/pubmed/32770480/ doi: 10.1007/s11886-020-01377-z id: cord-340908-8q7i5ds3 author: D’Ambrosi, Riccardo title: Guidelines for Resuming Elective Hip and Knee Surgical Activity Following the COVID-19 Pandemic: An Italian Perspective date: 2020-10-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33071683/ doi: 10.1007/s11420-020-09809-w id: cord-258930-60yn4hg7 author: D’Amico, Ferdinando title: Inflammatory bowel diseases and COVID-19: the invisible enemy date: 2020-04-16 words: 1027.0 sentences: 65.0 pages: flesch: 47.0 cache: ./cache/cord-258930-60yn4hg7.txt txt: ./txt/cord-258930-60yn4hg7.txt summary: All biological and immunosuppressive treatments were discontinued, visits in person were replaced by online consultations, and 318 patients were daily recommended to wash their hands frequently, to reduce the time spent outside the home and to use masks outside the home 7 . It is important to underline that a relevant percentage of evaluated patients had risk factors of infection: chronic diseases (15.4%), immunosuppressive agent therapy (11.0%), elderly (10.4%), high-risk professional categories (7.5%), and biological therapy (6.3%) 7 . Telemedicine has also been associated with a reduction in gastroenterological consultations and hospitalizations and could be a valid alternative to improve the quality of IBD patient care during the COVID-19 outbreak 23 . Comparative Risk of Serious Infections With Biologic and/or Immunosuppressive Therapy in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis Protection of 318 inflammatory bowel disease patients from the outbreak and rapid spread of COVID-19 infection in Wuhan abstract: nan url: https://doi.org/10.1053/j.gastro.2020.04.032 doi: 10.1053/j.gastro.2020.04.032 id: cord-265111-d44ireu5 author: D’Ardes, Damiano title: Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids date: 2020-08-31 words: 3103.0 sentences: 148.0 pages: flesch: 45.0 cache: ./cache/cord-265111-d44ireu5.txt txt: ./txt/cord-265111-d44ireu5.txt summary: A longer duration of COVID-19 with delayed clinical healing (symptom-free) occurred in patients presenting at admission a lower PaO(2)/FiO(2) ratio (p < 0.001), a more severe clinical presentation (p = 0.001) and a lower lymphocyte count (p = 0.035). All adult patients were diagnosed with COVID-19 according to World Health Organization (WHO) interim guidance: they had clinical symptoms of COVID-19 and confirmation of SARS-CoV-2 infection through instrumental signs and a positive result on RT-PCR assays of nasopharyngeal swab specimens. The specific inclusive criteria were as follows: (1) patients confirmed by positive detection of SARS-CoV-2 RNA from nasopharyngeal/throat swabs by RT-PCR with clinical data suggesting for COVID-19, (2) patients aged more than 18 years old and (3) patients with a known date of performing different RT-PCR assays. Disease severity and lower lymphocyte levels at admission also predict longer SARS-CoV-2 viral shedding. abstract: The diffusion of SARS-CoV-2, starting from China in December 2019, has led to a pandemic, reaching Italy in February 2020. Previous studies in Asia have shown that the median duration of SARS-CoV-2 viral shedding was approximately 12–20 days. We considered a cohort of patients recovered from COVID-19 showing that the median disease duration between onset and end of COVID-19 symptoms was 27.5 days (interquartile range (IQR): 17.0–33.2) and that the median duration between onset of symptoms and microbiological healing, defined by two consecutive negative nasopharyngeal swabs, was 38 days (IQR: 31.7–50.2). A longer duration of COVID-19 with delayed clinical healing (symptom-free) occurred in patients presenting at admission a lower PaO(2)/FiO(2) ratio (p < 0.001), a more severe clinical presentation (p = 0.001) and a lower lymphocyte count (p = 0.035). Moreover, patients presenting at admission a lower PaO(2)/FiO(2) ratio and more severe disease showed longer viral shedding (p = 0.031 and p = 0.032, respectively). In addition, patients treated with corticosteroids had delayed clinical healing (p = 0.013). url: https://www.ncbi.nlm.nih.gov/pubmed/32878286/ doi: 10.3390/microorganisms8091327 id: cord-018447-z4jyjczy author: D’Cruz, David P. title: Antiphospholipid (Hughes) Syndrome: An Overview date: 2006 words: 5167.0 sentences: 269.0 pages: flesch: 45.0 cache: ./cache/cord-018447-z4jyjczy.txt txt: ./txt/cord-018447-z4jyjczy.txt summary: The Antiphospholipid Antibodies in Stroke Study (APASS) Group also found a prevalence of aCL in 4.3% of 257 hospitalized non-stroke patients with a mean age 66 [16] . In a meta-analysis, Wahl examined the risk of venous thromboembolism in aPL-positive patients without autoimmune disease or previous thrombosis. The largest prospective study of 1000 SLE patients showed that after 10 years of follow up there were 68 deaths of whom 18 (26.5%) died from thrombosis associated with aPL [7] . However, studies in patients without lupus who are aPL positive have shown increased carotid intima-media thickness associated with an increased risk of arterial thrombosis [38] . In general, there are no significant differences in the cardinal clinical features of APS, such as arterial or venous thrombosis or pregnancy morbidity, whether the syndrome is primary or secondary to an underlying connective tissue disorder [33, 50] . abstract: In conclusion, the following observations can be made. aPL are present in approximately 2% to 4% of the normal population and the prevalence increases with age. There is a high prevalence among patients with autoimmune connective tissue disorders, especially SLE. There is an association with both venous and arterial thrombosis as well as with pregnancy morbidity, but the strength of association varies amongst studies. This probably reflects different populations, study designs, and different assays and definitions used. In several studies the risk of thrombosis appears to be higher with LA and the data suggests a true association rather than epiphenomenon. In a given patient, both aCL and LA should be measured. A significant impact on long-term survival has been noted and aPL also contribute significantly to accumulated damage in diseases such as SLE. The clinical spectrum of APS features is enormous and continues to expand. It behoves us all as clinicians and health care professionals to consider an early diagnosis of Hughes syndrome, with its distinct clinical and serological features, to reduce the risk of morbidity and mortality in our patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123322/ doi: 10.1007/1-84628-009-5_2 id: cord-311816-j8c2lk7y author: D’Elia, Emilia title: Coronavirus Disease 2019: Where are we and Where are we Going? Intersections Between Coronavirus Disease 2019 and the Heart date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which has become a pandemic affecting every country in the world. In the province of Bergamo, Italy, more than 2,200 cases of COVID-19 have been reported, which include more than 300 deaths. Most hospitalisations have been at the Papa Giovanni XXIII Hospital. This has imposed a significant burden on our hospital in terms of healthcare personnel, dedicated spaces (including intensive care areas) and time spent by clinicians, who are committed to assisting COVID-19 patients. In this short expert opinion, the authors will focus on new insights related to COVID-19 and the cardiovascular system, and try to investigate the grey areas and uncertainties in this field. url: https://www.ncbi.nlm.nih.gov/pubmed/32670618/ doi: 10.15420/cfr.2020.11 id: cord-269009-0i2bvt77 author: D’Souza, Rohan title: A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID‐19 date: 2020-08-05 words: 3295.0 sentences: 205.0 pages: flesch: 36.0 cache: ./cache/cord-269009-0i2bvt77.txt txt: ./txt/cord-269009-0i2bvt77.txt summary: Should patients develop coronavirus disease (COVID‐19) pneumonia requiring hospital admission for treatment of hypoxia, the risk for thromboembolic complications increases greatly. 2 As pregnancy is a prothrombotic state, the possibility of an increased risk of thrombosis in pregnant women with COVID-19 has become an area of concern, and a number of international organiPatients with severe COVID-19 may be at risk for pulmonary thromboembolic complications through at least two distinct mechanisms -immunothrombosis and hospital-associated venous thromboembolism (VTE). 12 A recent study of patients with severe COVID-19 demonstrated a correlation between IL-6 and fibrinogen levels, 3 further supporting the theory that massive activation of the acute phase response, with increased production of coagulation factors, appears to be the predominant prothrombotic mechanism in COVID-19. A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID-19 abstract: Those who are infected with Severe Acute Respiratory Syndrome‐related CoronaVirus‐2 are theoretically at increased risk of venous thromboembolism during self‐isolation if they have reduced mobility or are dehydrated. Should patients develop coronavirus disease (COVID‐19) pneumonia requiring hospital admission for treatment of hypoxia, the risk for thromboembolic complications increases greatly. These thromboembolic events are the result of at least two distinct mechanisms – microvascular thrombosis in the pulmonary system (immunothrombosis) and hospital‐associated venous thromboembolism. Since pregnancy is a prothrombotic state, there is concern regarding the potentially increased risk of thrombotic complications among pregnant women with COVID‐19. To date, however, pregnant women do not appear to have a substantially increased risk of thrombotic complications related to COVID‐19. Nevertheless, several organizations have vigilantly issued pregnancy‐specific guidelines for thromboprophylaxis in COVID‐19. Discrepancies between these guidelines reflect the altruistic wish to protect patients and lack of high‐quality evidence available to inform clinical practice. Low molecular weight heparin (LMWH) is the drug of choice for thromboprophylaxis in pregnant women with COVID‐19. However, its utility in non‐pregnant patients is only established against venous thromboembolism, as LMWH may have little or no effect on immunothrombosis. Decisions about initiation and duration of prophylactic anticoagulation in the context of pregnancy and COVID‐19 must take into consideration disease severity, outpatient vs inpatient status, temporal relation between disease occurrence and timing of childbirth, and the underlying prothrombotic risk conferred by additional comorbidities. There is currently no evidence to recommend the use of intermediate or therapeutic doses of LMWH in thromboprophylaxis, which may increase bleeding risk without reducing thrombotic risk in pregnant patients with COVID‐19. Likewise, there is no evidence to comment on the role of low‐dose aspirin in thromboprophylaxis or of anti‐cytokine and antiviral agents in preventing immunothrombosis. These unanswered questions are being studied within the context of clinical trials. url: https://doi.org/10.1111/aogs.13962 doi: 10.1111/aogs.13962 id: cord-292387-2xv3wgaq author: D′Agostino, Armando title: Brief Psychotic Disorder During the National Lockdown in Italy: An Emerging Clinical Phenomenon of the COVID-19 Pandemic date: 2020-08-06 words: 4555.0 sentences: 240.0 pages: flesch: 44.0 cache: ./cache/cord-292387-2xv3wgaq.txt txt: ./txt/cord-292387-2xv3wgaq.txt summary: Approximately 2 months after the COVID-19 outbreak in Lombardy and 50 days into national lockdown, we began to hospitalize patients with brief psychotic episodes at a remarkable rate. We report a case series of all consecutive patients admitted to the 2 psychiatric inpatient units of the San Paolo University Hospital who were discharged with a diagnosis of BPD during the COVID-19 pandemic lockdown in Milan, Italy (March 9 to May 18). In order to standardize the evaluation criteria, the following set of instruments was employed: the Brief Psychiatric Rating Scale (BPRS) 20 was performed as a global measure of psychopathology upon admission and at discharge; the presence of stressful life events in the 12 months before the lockdown was assessed using Paykel''s interview for recent life events 21 ; the Structured Clinical Interview for DSM (SCID-II) 22 was performed to evaluate the presence of a personality disorder; and the Temperament and Character Inventory-240 items (TCI-240) 23 was administered to investigate personality dimensions. abstract: The impact of the COVID-19 pandemic on psychosis remains to be established. Here we report 6 cases (3 male and 3 female) of first-episode psychosis (FEP) admitted to our hospital in the second month of national lockdown. All patients underwent routine laboratory tests and a standardized assessment of psychopathology. Hospitalization was required due to the severity of behavioral abnormalities in the context of a full-blown psychosis (the Brief Psychiatric Rating Scale [BPRS] = 75.8 ± 14.6). Blood tests, toxicological urine screening, and brain imaging were unremarkable, with the exception of a mild cortical atrophy in the eldest patient (male, 73 years). All patients were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) throughout their stay, but 3 presented the somatic delusion of being infected. Of note, all 6 cases had religious/spiritual delusions and hallucinatory contents. Despite a generally advanced age (53.3 ± 15.6), all patients had a negative psychiatric history. Rapid discharge (length of stay = 13.8 ± 6.9) with remission of symptoms (BPRS = 27.5 ± 3.1) and satisfactory insight were possible after relatively low-dose antipsychotic treatment (Olanzapine-equivalents = 10.1 ± 5.1 mg). Brief psychotic disorder/acute and transient psychotic disorder diagnoses were confirmed during follow-up visits in all 6 cases. The youngest patient (female, 23 years) also satisfied the available criteria for brief limited intermittent psychotic symptoms. Although research on larger populations is necessary, our preliminary observation suggests that intense psychosocial stress associated with a novel, potentially fatal disease and national lockdown restrictions might be a trigger for FEP. url: https://www.ncbi.nlm.nih.gov/pubmed/32761196/ doi: 10.1093/schbul/sbaa112 id: cord-262766-ndn6iwre author: Easom, Nicholas title: 68 Consecutive patients assessed for COVID-19 infection; experience from a UK regional infectious disease unit date: 2020-03-06 words: 2964.0 sentences: 145.0 pages: flesch: 45.0 cache: ./cache/cord-262766-ndn6iwre.txt txt: ./txt/cord-262766-ndn6iwre.txt summary: Clinical assessment of possible infection with SARS-CoV-2, the novel coronavirus responsible for the outbreak of COVID-19 respiratory illness, has been a major activity of infectious diseases services in the UK and elsewhere since the first report of cases in December 2019. In addition, many mild respiratory viral infections were managed as influenza 10 , with significant resource implications, both for healthcare services and patients Here we describe our experience of the first 68 patients we have tested for SARS-CoV-2 at a Regional Infectious Diseases unit (RIDU) in the UK. Specialist Infectious Diseases consultant-delivered assessment of a group of patients who predominantly have mild illness is unlikely to be sustainable, especially as the case-definition broadens to include a wider geographical area and/or COVID-19 patients requiring inpatient care becomes more common in the UK. abstract: Clinical assessment of possible infection with SARS-CoV-2, the novel coronavirus responsible for the outbreak of COVID-19 respiratory illness, has been a major activity of infectious diseases services in the UK and elsewhere since the first report of cases in December 2019. We report our case series of 68 patients, reviewed by Infectious Diseases Consultants at a Regional Infectious Diseases Unit in the UK. We prospectively evaluated our service between the 29th Jan 2020 and 24th Feb 2020. Demographic, clinical, epidemiological and laboratory data were collected. We have compared clinical features and subsequent diagnosis between well patients not requiring admission for clinical reasons or antimicrobials with those assessed as needing either admission or antimicrobial treatment. Final microbiological diagnoses included SARS-CoV-2 (COVID-19), Mycoplasma pneumonia, influenza A, RSV, non SARS/MERS coronaviruses, rhinovirus/enterovirus. 9/68 were treated with antimicrobials, 15/68 were admitted to a negative pressure room of whom 5/68 were admitted solely due to an inability to isolate at home. Patients requiring either admission on clinical grounds or antimicrobials (14/68) were similar to those not requiring admission or antimicrobials, with modestly more fever and shortness of breath in the clinically admitted / antimicrobial group. The most commonly prescribed antimicrobials were doxycycline, moxifloxacin and oseltamivir. The majority of patients had mild illness which did not require a clinical intervention to manage. This finding supports a community testing approach supported by clinicians to review the proportion of more unwell patients. url: https://doi.org/10.1101/2020.02.29.20029462 doi: 10.1101/2020.02.29.20029462 id: cord-319706-2e9jrv0s author: Ebinger, Joseph E. title: Pre-existing traits associated with Covid-19 illness severity date: 2020-07-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: IMPORTANCE: Certain individuals, when infected by SARS-CoV-2, tend to develop the more severe forms of Covid-19 illness for reasons that remain unclear. OBJECTIVE: To determine the demographic and clinical characteristics associated with increased severity of Covid-19 infection. DESIGN: Retrospective observational study. We curated data from the electronic health record, and used multivariable logistic regression to examine the association of pre-existing traits with a Covid-19 illness severity defined by level of required care: need for hospital admission, need for intensive care, and need for intubation. SETTING: A large, multihospital healthcare system in Southern California. PARTICIPANTS: All patients with confirmed Covid-19 infection (N = 442). RESULTS: Of all patients studied, 48% required hospitalization, 17% required intensive care, and 12% required intubation. In multivariable-adjusted analyses, patients requiring a higher levels of care were more likely to be older (OR 1.5 per 10 years, P<0.001), male (OR 2.0, P = 0.001), African American (OR 2.1, P = 0.011), obese (OR 2.0, P = 0.021), with diabetes mellitus (OR 1.8, P = 0.037), and with a higher comorbidity index (OR 1.8 per SD, P<0.001). Several clinical associations were more pronounced in younger compared to older patients (P(interaction)<0.05). Of all hospitalized patients, males required higher levels of care (OR 2.5, P = 0.003) irrespective of age, race, or morbidity profile. CONCLUSIONS AND RELEVANCE: In our healthcare system, greater Covid-19 illness severity is seen in patients who are older, male, African American, obese, with diabetes, and with greater overall comorbidity burden. Certain comorbidities paradoxically augment risk to a greater extent in younger patients. In hospitalized patients, male sex is the main determinant of needing more intensive care. Further investigation is needed to understand the mechanisms underlying these findings. url: https://doi.org/10.1371/journal.pone.0236240 doi: 10.1371/journal.pone.0236240 id: cord-266905-j9ljwqv0 author: Ecker, Jeffrey L. title: Laboring Alone?: Brief Thoughts on Ethics and Practical Answers During the COVID-19 Pandemic date: 2020-05-15 words: 3575.0 sentences: 171.0 pages: flesch: 57.0 cache: ./cache/cord-266905-j9ljwqv0.txt txt: ./txt/cord-266905-j9ljwqv0.txt summary: Condensation: To minimize risk of exposure to health care workers, some have proposed eliminating 4 spouses, partners and other visitors to support women during their labor and delivery. In most institutions, however, labor and delivery units have been rare exceptions to the "no-visitor" 23 rules, for visitors there are felt to have, in the words of the New York Department of Health, an 24 "essential" role in process of care, and not having a partner present for the birth of a child seems 25 unimaginable,unkind and, for some, even traumatic. As 100 noted above, the process of labor and delivery requires close quarters, but it is difficult to estimate the 101 true incremental risk that comes with accompanying and supporting a patient, especially if members of 102 the health care team are symptom free and wearing appropriate PPE. abstract: nan url: https://doi.org/10.1016/j.ajogmf.2020.100141 doi: 10.1016/j.ajogmf.2020.100141 id: cord-025666-u8w4sk07 author: Edgar, DW title: Seeding the value based health care and standardised measurement of quality of life after burn debate date: 2020-05-30 words: 1668.0 sentences: 89.0 pages: flesch: 54.0 cache: ./cache/cord-025666-u8w4sk07.txt txt: ./txt/cord-025666-u8w4sk07.txt summary: These surveys provide us with an important view of an individual''s health across multiple domains which go beyond any pathophysiological measure and there is substantial literature validating PROMs in particular, for use after burn injuries [6, 7] . Notwithstanding, the availability of computerised adaptive testing, the instruments established and emerging include: a) Medical Outcome Study Short Form -36 item (SF-36) [9] for generic QoL measurement in adult burn patients. The SF-36 is a widely applied instrument and the most often used generic instrument to assess QoL in burns [8, 10] , it is validated for use in the adult burn patient population [11] , and it covers many domains that are also covered by the most applied burn specific QoL measure [12] . A systematic review of patient-reported outcome measures used in adult burn research Demonstration of the validity of the SF-36 for measurement of the temporal recovery of quality of life outcomes in burns survivors abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260548/ doi: 10.1016/j.burns.2020.05.024 id: cord-011302-pfepyvaw author: Edlmann, Ellie title: The changing face of neurosurgery for the older person date: 2020-04-25 words: 3889.0 sentences: 180.0 pages: flesch: 43.0 cache: ./cache/cord-011302-pfepyvaw.txt txt: ./txt/cord-011302-pfepyvaw.txt summary: In this review, we consider changes in practice and current treatment outcomes in older patients with aneurysmal subarachnoid haemorrhage, traumatic head injury, and haemorrhagic strokes. A recent systematic review of endovascular treatment of ruptured aneurysms in patients aged over 65 reported good outcomes in 66%, with a mortality rate of around 26% at 1 year [36] . Koffijberg analysed the cost-effectiveness of treating ruptured aneurysms in patients aged over 70, identifying key parameters including patient age (and thus life expectancy), good or poor clinical condition on presentation, conservative or occlusive treatment (clipping or coiling) and good or poor outcomes [18] . This is supported by collaborations such as IMPACT (International Mission for Prognosis and Analysis of Clinical Trials in TBI) and CRASH (Corticosteroid Randomisation After Significant Head injury), who have used available evidence to develop prognostic calculators for TBI, where age is a corestratifying component and significantly increases chances of a poor outcome [17, 38] . abstract: Increased life expectancy and illness prevention and treatment have led to a growing population of older patients. These changes in patient population are apparent in neurosurgery; however, relatively little is reported about specific outcomes and prognostication in this group. This review summarises the challenges and management changes occurring in the treatment of three common neurosurgical pathologies; aneurysmal subarachnoid haemorrhage, head injury, and haemorrhagic stroke. A move towards less invasive neurosurgical techniques has implications on the risk–benefit profile of interventions. This creates the opportunity to intervene in older patients with greater co-morbidity, as long as improved outcomes can be evidenced. A critical part of assessing appropriateness for surgical intervention in older patients may be to change from a mindset of age to one of frailty and growing interest in scales assessing this may aid treatment decisions in the future. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223995/ doi: 10.1007/s00415-020-09854-9 id: cord-344017-qldawc8m author: Edouard, S. title: Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France date: 2020-11-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: An indirect in-house immunofluorescent assay was developed in order to assess the serological status of COVID-19 patients in Marseille, France. Performance of IFA was compared to a commercial ELISA IgG kit. We tested 888 RT-qPCR-confirmed COVID-19 patients (1302 serum samples) and 350 controls including 200 sera collected before the pandemic, 64 sera known to be associated with nonspecific serological interference, 36 sera from non-coronavirus pneumonia and 50 sera from patient with other common coronavirus to elicit false-positive serology. Incorporating an inactivated clinical SARS-CoV-2 isolate as the antigen, the specificity of the assay was measured as 100% for IgA titre ≥ 1:200, 98.6% for IgM titre ≥ 1:200 and 96.3% for IgG titre ≥ 1:100 after testing a series of negative controls. IFA presented substantial agreement (86%) with ELISA EUROIMMUN SARS-CoV-2 IgG kit (Cohen’s Kappa = 0.61). The presence of antibodies was then measured at 3% before a 5-day evolution up to 47% after more than 15 days of evolution. We observed that the rates of seropositivity as well as the titre of specific antibodies were both significantly higher in patients with a poor clinical outcome than in patients with a favourable evolution. These data, which have to be integrated into the ongoing understanding of the immunological phase of the infection, suggest that detection anti-SARS-CoV-2 antibodies is useful as a marker associated with COVID-19 severity. The IFA assay reported here is useful for monitoring SARS-CoV-2 exposure at the individual and population levels. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-020-04104-2. url: https://www.ncbi.nlm.nih.gov/pubmed/33179133/ doi: 10.1007/s10096-020-04104-2 id: cord-003446-yp5d29fk author: Edwards, Michael title: An Uncommon Cause of Spontaneous Pneumomediastinum and Subcutaneous Emphysema date: 2017-02-03 words: 1284.0 sentences: 83.0 pages: flesch: 42.0 cache: ./cache/cord-003446-yp5d29fk.txt txt: ./txt/cord-003446-yp5d29fk.txt summary: A 79-year-old gentleman presented with spontaneous pneumomediastinum and subcutaneous emphysema with pneumonia but no pre-existing lung disease. After 4 days of intravenous antibiotics, the patient developed considerable subcutaneous emphysema and pneumomediastinum. Pneumomediastinum presents most commonly with chest pain, shortness of breath, and subcutaneous emphysema. Treatment of pneumomediastinum is typically conservative, and although options may be limited, aggressive management of any causative factor may be essential in selected cases. A case of spontaneous pneumomediastinum and subcutaneous emphysema in a 79-year-old gentleman with pneumonia but no pre-existing lung disease is presented. A 79-year-old gentleman presented with a 4-day history of increased shortness of breath, pleuritic chest pain, fevers, and non-productive cough. A repeat chest x-ray showed extensive subcutaneous emphysema and led to a diagnosis of suspected pneumomediastinum. Pneumomediastinum presents most commonly with chest pain, shortness of breath, and subcutaneous emphysema but rhinolalia, cough, neck pain, emesis, and dysphagia are also possible [4] . abstract: A 79-year-old gentleman presented with spontaneous pneumomediastinum and subcutaneous emphysema with pneumonia but no pre-existing lung disease. He presented with a 4-day history of increased shortness of breath, pleuritic chest pain, fevers, and non-productive cough. After 4 days of intravenous antibiotics, the patient developed considerable subcutaneous emphysema and pneumomediastinum. Pneumomediastinum presents most commonly with chest pain, shortness of breath, and subcutaneous emphysema. It has previously been associated with cases of pneumonia but often with rare strains such as P. jirovecii pneumonia in immunocompromised patients. This case highlights spontaneous pneumomediastinum as a rare complication of pneumonia. Treatment of pneumomediastinum is typically conservative, and although options may be limited, aggressive management of any causative factor may be essential in selected cases. LEARNING POINTS: Pneumomediastinum and subcutaneous emphysema are rare complications of pneumonia. Computerised tomography is a valuable diagnostic tool for identifying pneumomediastinum in patients with subcutaneous emphysema. While pneumomediastinum is typically a benign condition, aggressive management may occasionally be required. Evidence regarding use of non-invasive/invasive ventilation remains limited but it may theoretically aggravate any air leakage. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346762/ doi: 10.12890/2017_000549 id: cord-016413-lvb79oxo author: Efthimiou, Petros title: Adult-Onset Still’s Disease date: 2018-07-14 words: 6126.0 sentences: 315.0 pages: flesch: 40.0 cache: ./cache/cord-016413-lvb79oxo.txt txt: ./txt/cord-016413-lvb79oxo.txt summary: Adult-onset Still''s disease (AOSD) is a rare systemic, autoinflammatory disorder that often presents in adolescence and early adulthood with fever, rash, and polyarthritis. Mutation of perforin and the MUNC13-4 genes have been seen in patients with macrophage activation syndrome (MAS), a known severe, life-threatening complication of AOSD [3] . Patients who have the chronic articular disease pattern can present with joint erosions making the differential diagnosis from RA problematic, especially in the absence of systemic signs and symptoms. Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France Effectiveness of first-line treatment with recombinant interleukin-1 receptor antagonist in steroid-naive patients with new-onset systemic juvenile idiopathic arthritis: results of a prospective cohort study Clinical manifestations of adult-onset Still''s disease presenting with erosive arthritis: association with low levels of ferritin and Interleukin-18 abstract: Adult-onset Still’s disease (AOSD) is a rare systemic, autoinflammatory disorder that often presents in adolescence and early adulthood with fever, rash, and polyarthritis. There are significant genetic and clinical similarities with systemic juvenile idiopathic arthritis (sJIA) with a different chronological disease onset. The disease can have many protean characteristics leading to delays in diagnosis. Treatment includes corticosteroids; traditional immunomodulators, such as methotrexate; and targeted biologic treatments that include IL-1 and IL-6 inhibitors. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120682/ doi: 10.1007/978-3-319-96929-9_19 id: cord-342555-5r9aa7u5 author: Eghtesadi, Marzieh title: Breaking Social Isolation Amidst COVID‐19: A Viewpoint on Improving Access to Technology in Long‐Term Care Facilities date: 2020-04-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32277470/ doi: 10.1111/jgs.16478 id: cord-262729-qcijsyo6 author: Eichberg, Daniel G title: Letter: Academic Neurosurgery Department Response to COVID-19 Pandemic: The University of Miami/Jackson Memorial Hospital Model date: 2020-04-11 words: 1089.0 sentences: 78.0 pages: flesch: 45.0 cache: ./cache/cord-262729-qcijsyo6.txt txt: ./txt/cord-262729-qcijsyo6.txt summary: Therefore, we have empowered a small neurosurgery COVID team consisting of senior neurosurgeons with multidisciplinary backgrounds who review a brief history and select imaging studies and make decisions for urgent surgical cases. We continue to schedule clinic visits to evaluate potentially urgent surgical patients, which are determined during a clinic prescreen. Since implementation, we have decreased the number of clinic visits by 80%; however, we continue to see and evaluate the same number of patients prior to this protocol. Only the minimal number of residents and/or fellows required for patient care are allowed to come to the hospital. To minimize faculty exposure, we have re-organized the call schedules so that one provider covers multiple hospitals and sub-specialties -with appropriate at home Postoperative neurosurgical patients are often medically fragile; thus exposure to COVID-19 may be extremely deleterious. During the COVID-19 pandemic, emergent and urgent neurosurgical procedures should continue to be performed, while deferring elective surgeries. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32277754/ doi: 10.1093/neuros/nyaa118 id: cord-322394-b18fv3r3 author: Eichberg, Daniel G title: Telemedicine in Neurosurgery: Lessons Learned from a Systematic Review of the Literature for the COVID-19 Era and Beyond date: 2020-07-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Evolving requirements for patient and physician safety and rapid regulatory changes have stimulated interest in neurosurgical telemedicine in the COVID-19 era. OBJECTIVE: To conduct a systematic literature review investigating treatment of neurosurgical patients via telemedicine, and to evaluate barriers and challenges. Additionally, we review recent regulatory changes that affect telemedicine in neurosurgery, and our institution's initial experience. METHODS: A systematic review was performed including all studies investigating success regarding treatment of neurosurgical patients via telemedicine. We reviewed our department's outpatient clinic billing records after telemedicine was implemented from 3/23/2020 to 4/6/2020 and reviewed modifier 95 inclusion to determine the number of face-to-face and telemedicine visits, as well as breakdown of weekly telemedicine clinic visits by subspecialty. RESULTS: A total of 52 studies (25 prospective and 27 retrospective) with 45 801 patients were analyzed. A total of 13 studies were conducted in the United States and 39 in foreign countries. Patient management was successful via telemedicine in 99.6% of cases. Telemedicine visits failed in 162 cases, 81.5% of which were due to technology failure, and 18.5% of which were due to patients requiring further face-to-face evaluation or treatment. A total of 16 studies compared telemedicine encounters to alternative patient encounter mediums; telemedicine was equivalent or superior in 15 studies. From 3/23/2020 to 4/6/2020, our department had 122 telemedicine visits (65.9%) and 63 face-to-face visits (34.1%). About 94.3% of telemedicine visits were billed using face-to-face procedural codes. CONCLUSION: Neurosurgical telemedicine encounters appear promising in resource-scarce times, such as during global pandemics. url: https://www.ncbi.nlm.nih.gov/pubmed/32687191/ doi: 10.1093/neuros/nyaa306 id: cord-028379-ghudhac6 author: Eichenberger, Emily M. title: Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria date: 2020-07-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The complement system is a vital component of the innate immune system, though its role in bacteremia is poorly understood. We present complement levels in Staphylococcus aureus bacteremia (SAB) and Gram-negative bacteremia (GNB) and describe observed associations of complement levels with clinical outcomes. Complement and cytokine levels were measured in serum samples from 20 hospitalized patients with SAB, 20 hospitalized patients with GNB, 10 non-infected hospitalized patients, and 10 community controls. C5a levels were significantly higher in patients with SAB as compared to patients with GNB. Low C4 and C3 levels were associated with septic shock and 30-day mortality in patients with GNB, and elevated C3 was associated with a desirable outcome defined as absence of (1) septic shock, (2) acute renal failure, and (3) death within 30 days of bacteremia. Low levels of C9 were associated with septic shock in patients with GNB but not SAB. Elevated IL-10 was associated with increased 30-day mortality in patients with SAB. Complement profiles differ in patients with SAB and those with GNB. Measurement of IL-10 in patients with SAB and of C4, C3, and C9 in patients with GNB may help to identify those at higher risk for poor outcomes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10096-020-03955-z) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334117/ doi: 10.1007/s10096-020-03955-z id: cord-318167-b25g6zkp author: Einollahi, Behzad title: A patient affected by critical COVID-19 pneumonia, successfully treated with convalescent plasma date: 2020-11-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We present a critically ill patient affected by COVID-19, whose chest computed tomography (CT) scan featured lung consolidations and severe patchy ground-glass opacitie. On day 3 since hospital admission the patient was placed on convalescent plasma treatment. A combined treatment with supportive care, hemoperfusion and convalescent plasma successfully managed to save the patient’s life. Convalescent plasma probably contributed to heal this patient and should always be considered in the management of critically ill COVID-19 cases. url: https://api.elsevier.com/content/article/pii/S1473050220303189 doi: 10.1016/j.transci.2020.102995 id: cord-006841-3u56erru author: Einsele, Hermann title: Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) date: 2003-09-10 words: 5273.0 sentences: 281.0 pages: flesch: 34.0 cache: ./cache/cord-006841-3u56erru.txt txt: ./txt/cord-006841-3u56erru.txt summary: The number of stem cells in the graft and the type of GvHD prophylaxis are factors which determine the rate of hematopoeitic reconstitution and may therefore also influence incidence and severity of infections during the early post-transplantation period. Modification of empiric antimicrobial regimens in patients with neutropenic fever after allogeneic stem cell transplantation When the causative agent of an infection has been identified, antibacterial therapy should be adapted according to the resistance pattern of the pathogen. If fever occurs in a patient later than 100 days after allogeneic stem cell transplantation, the upper and lower respiratory tract (bronchitis, pneumonia, sinusitis), and bacteremias have to be considered as specific foci of infections. Clinical manifestations of adenovirus infections in patients after allogeneic stem cell transplantation that have been reported so far include pneumonia, hepatitis, cystitis, diarrhea, and also disseminated disease (for diagnostic procedures see Table 3 ). abstract: The risk of infection after allogeneic stem cell transplantation is determined by the underlying disease, the intensity of previous treatments and complications that may have occurred during that time, but above all, the risk of infection is determined by the selected transplantation modality (e.g. HLA-match between the stem cell donor and recipient, T cell depletion of the graft, and others). In comparison with patients treated with high-dose chemotherapy and autologous stem cell transplantation, patients undergoing allogeneic stem cell transplantation are at a much higher risk of infection even after hematopoietic reconstitution, due to the delayed recovery of T and B cell functions. The rate at which immune function recovers after hematopoietic reconstitution greatly influences the incidence and type of post-transplant infectious complications. Infection-associated mortality, for example, is significantly higher following engraftment than during the short neutropenic period that immediately follows transplantation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103165/ doi: 10.1007/s00277-003-0772-4 id: cord-327214-kcbxyhhh author: Eketunde, Adenike O title: A Review of Postmortem Findings in Patients With COVID-19 date: 2020-07-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Multiple public health problems have been caused by various coronavirus strains over the last few years, such as the middle eastern respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), and COVID-19. COVID-19, which is also known as coronavirus disease 2019, was first detected in Wuhan, China, and has significantly impacted people's health and lives. Additionally, it has led to a pandemic, and the virus has spread to over 121 countries worldwide. There is numerous information available regarding this virus. A detailed and extensive study of the morphological and histopathological findings will help understand and diagnose the disease. As it is a new disease, it is challenging to understand the mechanism of the action and disease pathology due to the limited availability of data from autopsies or biopsies. However, as the detailed mechanism of injury remains unclear, this paper aims to review the postmortem gross and histopathological findings of various organs that have been affected with coronavirus, focusing on the pulmonary, cardiac, and hematologic findings. This paper emphasizes the postmortem findings of the effect of the coronavirus disease on multiple organ systems. Advance search of the keywords on PubMed was used, limiting the search to the last five years. The eligible article is narrowed based on relevance containing postmortem findings of the novel virus; COVID-19. A total of 25 full-text articles were selected and used in the review of this paper. url: https://www.ncbi.nlm.nih.gov/pubmed/32864262/ doi: 10.7759/cureus.9438 id: cord-282021-m1lh7mzd author: El Shamy, Osama title: Telenephrology with Remote Peritoneal Dialysis Monitoring during Coronavirus Disease 19 date: 2020-04-28 words: 1569.0 sentences: 74.0 pages: flesch: 48.0 cache: ./cache/cord-282021-m1lh7mzd.txt txt: ./txt/cord-282021-m1lh7mzd.txt summary: In California''s COVID-19 epicenter, some Silicon Valley hospitals place emphasis on data privacy, main-El Shamy/Tran/Sharma/Ronco/ Narayanan/Uribarri Am J Nephrol 2 DOI: 10.1159/000508023 taining strict policies with strong preference for providers and patients to use hospital-approved technology. Performing monthly telehealth visits would not be possible for this patient population without the ability to remotely monitor their treatments to assess the quality of the home therapy delivered and troubleshoot any issues that may arise. To date, over 90% of Mount Sinai''s home dialysis patients have had their monthly visits conducted through telehealth without having to come to the unit for any of their needs. In less urban areas not currently affected as much by COVID-19, such as at Baylor Scott and White Healthcare in Temple, Texas, nephrologists are bracing for an onslaught and have preemptively started using telemedicine for the monthly visits with their home dialysis patients while utilizing the benefits of Sharesource to re-motely monitor, adjust, and troubleshoot their patients'' dialysis treatments. abstract: nan url: https://doi.org/10.1159/000508023 doi: 10.1159/000508023 id: cord-148109-ql1tthyr author: El-Din, Doaa Mohey title: E-Quarantine: A Smart Health System for Monitoring Coronavirus Patients for Remotely Quarantine date: 2020-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus becomes officially a global pandemic due to the speed spreading off in various countries. An increasing number of infected with this disease causes the Inability problem to fully care in hospitals and afflict many doctors and nurses inside the hospitals. This paper proposes a smart health system that monitors the patients holding the Coronavirus remotely. Due to protect the lives of the health services members (like physicians and nurses) from infection. This smart system observes the people with this disease based on putting many sensors to record many features of their patients in every second. These parameters include measuring the patient's temperature, respiratory rate, pulse rate, blood pressure, and time. The proposed system saves lives and improves making decisions in dangerous cases. It proposes using artificial intelligence and Internet-of-things to make remotely quarantine and develop decisions in various situations. It provides monitoring patients remotely and guarantees giving patients medicines and getting complete health care without anyone getting sick with this disease. It targets two people's slides the most serious medical conditions and infection and the lowest serious medical conditions in their houses. Observing in hospitals for the most serious medical cases that cause infection in thousands of healthcare members so there is a big need to uses it. Other less serious patients slide, this system enables physicians to monitor patients and get the healthcare from patient's houses to save places for the critical cases in hospitals. url: https://arxiv.org/pdf/2005.04187v1.pdf doi: nan id: cord-278984-0zof6s4d author: El-Tallawy, Salah N. title: Pain Management During the COVID-19 Pandemic date: 2020-08-25 words: 6475.0 sentences: 337.0 pages: flesch: 46.0 cache: ./cache/cord-278984-0zof6s4d.txt txt: ./txt/cord-278984-0zof6s4d.txt summary: Understanding both the general problems facing chronic pain patients as well as specific problems in the COVID-19 era including deconditioning, increased mental health concerns, financial burdens, and potential for medication-induced immune-suppression is vital in the appropriate management of patients. Understanding both the general problems facing chronic pain patients as well as specific problems in the COVID-19 era including deconditioning, increased mental health concerns, financial burdens, and potential for medication-induced immune-suppression is vital in the appropriate management of patients. Recent recommendations for the safe use of non-opioid analgesics, opioid analgesics, and interventional pain management procedures are vital to know and understand specifically during the pandemic era. Immunosuppression as a result of medication, whether chronic opioid therapy or the use of oral or injectable steroids (e.g., in interventional pain procedures), is especially concerning during a time of global pandemic. Telemedicine has become an effective way of providing necessary medical services to patients with chronic pain during the COVID-19 epidemic. abstract: Chronic pain management during the coronavirus disease 2019 (COVID-19) pandemic is a challenging process, especially with growing evidence that COVID-19 infection is associated with myalgias, referred pain, and widespread hyperalgesia. In light of the limited data available for COVID-19-related impact on chronic pain patients, this review explores the changes in the healthcare delivery system due to social distancing and safety precautions to provide the appropriate management of chronic pain patients during the COVID-19 pandemic. Understanding both the general problems facing chronic pain patients as well as specific problems in the COVID-19 era including deconditioning, increased mental health concerns, financial burdens, and potential for medication-induced immune-suppression is vital in the appropriate management of patients. Telemedicine, the practice of caring for patients remotely when the provider and patient are not physically present with each other, is becoming increasingly used and recognized as a valuable tool to both health care providers and patients. This paper concentrates on the proper utilization of the available resources to help patients with the most severe conditions as well as the most vulnerable group. COVID-19 may be associated with a profound effect on both the health care system and patients with chronic pain. As a result, delaying, or stopping, treatment for chronic pain patients will have negative consequences, and strong pain evaluations must be administered to triage patients appropriately. Recent recommendations for the safe use of non-opioid analgesics, opioid analgesics, and interventional pain management procedures are vital to know and understand specifically during the pandemic era. Further researches are needed to identify the advance planning and rapid responses to reduce the impact of the pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32840756/ doi: 10.1007/s40122-020-00190-4 id: cord-305283-1bg1ykui author: ElSeirafi, Mohamed MA. title: Efficacy and safety of tocilizumab in critically ill adults with COVID-19 infection in Bahrain: A report of 5 cases date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Tocilizumab has been recognized as one of the few existing biologic useful for combating COVID-19 infections especially in critically ill patient. We had experience in treating five critically ill patients with severe lung injury who were COVID-19 positive with tocilizumab. In the present case series, we have attempted to summarize their clinical profile, changes in laboratory biomarkers and outcomes. url: https://doi.org/10.1016/j.rmcr.2020.101139 doi: 10.1016/j.rmcr.2020.101139 id: cord-340650-mwsa326c author: Elangovan, E. J. title: Rationale and prognosis of repurposed drugs with risk stratification of patients in oxygen support in COVID-19: A systematic review and meta-analysis date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There has been rapid development of clinical trials conducted on antivirals, immunomodulators, and other therapies against COVID-19. The rising number of trials has led to duplication and a need for curation of available outcomes from treatments that have been followed across the world. The rising number of trials has led to duplication and a need for curation of available outcomes from treatments that have been followed across the world. We have conducted a systematic review and meta analysis that focus on evaluating the clinical outcomes of repurposed drugs against COVID-19 including Tocilizumab, Remdesivir, Dexamethasome, Lopinavir-ritonavir, Favipiravir, Hydroxychloroquine, and Convalescent plasma therapy. Twenty-nine articles were included in this study after thorough literature search and performed subgroup analyses based on disease severity levels. Random effects model was adopted to estimate overall treatment effect and heterogeneity. Subgroup analysis on mortality rate showed significant overall effect in the treatment group of studies having critically ill patients (p<0.01).Overall, our study confirmed that tocilizumab may probably reduce the mortality (<10%) of patients with COVID-19 with faster recovery time and reduce the risk of patients with lung disease in falling into oxygen support (P = 0.02). Patients on remedesivir showed no significant associations of comorbidities with risk of falling into oxygen supports. Hydroxychloroquine was found to be inefficacious in COVID-19 patients (OR 0.64; 95%CI [0.47-0.86]).Dexamethasone had marginal effect on overall mortality rate (OR 1.19; 95%CI [1.05-1.35]), and hence helpful for patients on mechanical ventilation or ECMO. There was also evidence suggesting that combination therapies (serpin + Favipiravir) were helpful in reducing the mortality rate in COVID-19 patients under invasive support. url: http://medrxiv.org/cgi/content/short/2020.10.04.20206516v1?rss=1 doi: 10.1101/2020.10.04.20206516 id: cord-327017-b2refzfw author: Elbeddini, Ali title: Pharmacist intervention amid the coronavirus disease 2019 (COVID-19) pandemic: from direct patient care to telemedicine date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease (COVID-19) pandemic has placed enormous pressures on the Canadian healthcare system. Patients are expected to stay home in order to contain the spread of the virus, but understandably have numerous questions and concerns about their health. With physical distancing being of utmost importance during the pandemic, much of healthcare has been forced to move online or over the telephone. Virtual healthcare, in the form of video calls, email, or telephone calls with patients, can significantly enhance access to healthcare. Many clinics have moved their appointments online, and physicians are seeing their patients by means of online video calls. Similarly, patients are refilling their prescriptions online and calling pharmacists whenever they have questions about their medications or medical conditions. Pharmacists are considered the most accessible primary care providers, so it is crucial for patients to know that pharmacists are there to support them throughout the pandemic. url: https://doi.org/10.1186/s40545-020-00229-z doi: 10.1186/s40545-020-00229-z id: cord-330877-nsx4b4rm author: Elcioglu, Omer Celal title: COVİD-19 infection in a membranous nephropathy patient treated with rituximab date: 2020-09-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: While COVID-19 pandemic continues to affect our country and most countries in the world, we have to make some changes both in our social life and our approach to healthcare. We have to struggle with the pandemic on one hand and also try to follow up and treat our patients with chronic diseases in the most appropriate way. In this period, one of our group of patients who are challenging us for follow-up and treatment are those who should start or continue to use immunosuppressive therapy. In order to contribute to the accumulation of knowledge in this area, we wanted to report a patient who was followed up with the diagnosis of COVID-19 and had been administered rituximab very recently due to a nephrotic syndrome caused by membranous nephropathy. url: https://doi.org/10.1007/s13730-020-00524-3 doi: 10.1007/s13730-020-00524-3 id: cord-335265-kuc3v5m9 author: Elghazawy, Hagar title: Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic date: 2020-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Breast cancer is the most common malignancy among women worldwide. The current COVID-19 pandemic represents an unprecedented challenge leading to care disruption, which is more severe in low- and middle-income countries (LMIC) due to existing economic obstacles. This review presents the global perspective and preparedness plans for breast cancer continuum of care amid the COVID-19 outbreak and discusses challenges faced by LMIC in implementing these strategies. Prioritization and triage of breast cancer patients in a multidisciplinary team setting are of paramount importance. Deescalation of systemic and radiation therapy can be utilized safely in selected clinical scenarios. The presence of a framework and resource-adapted recommendations exploiting available evidence-based data with judicious personalized use of current resources is essential for breast cancer care in LMIC during the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32715776/ doi: 10.2217/fon-2020-0574 id: cord-298094-ctikhqvr author: Elias, Pierre title: The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19 date: 2020-08-15 words: 4165.0 sentences: 248.0 pages: flesch: 52.0 cache: ./cache/cord-298094-ctikhqvr.txt txt: ./txt/cord-298094-ctikhqvr.txt summary: The principal findings of this study include: (1) rapid clinical deterioration is common in admitted patients, with 53% of intubations occurring within 48 hours, (2) 33% of admitted patients either died or required mechanical ventilation within fourteen days of COVID-19 diagnosis, and (3) combining abnormal ECG and abnormal respiratory vital signs quickly identifies a group of patients at high risk for mechanical ventilation or death. In this study, we sought to determine if data available early in a patient''s emergency department presentation (demographics, comorbidities, vital signs, and ECG) could prognosticate the composite outcome of mechanical ventilation or death by 48 hours after COVID-19 diagnosis. In this study, we sought to determine if data available early in a patient''s emergency department presentation (demographics, comorbidities, vital signs, and ECG) could prognosticate the composite outcome of mechanical ventilation or death by 48 hours after COVID-19 diagnosis. abstract: ABSTRACT Background Rapid risk stratification is essential during the COVID-19 pandemic. We aimed to study whether combining vital signs and electrocardiogram (ECG) analysis can improve early prognostication. Methods 1,258 adults with COVID-19 seen at three hospitals in New York in March and April 2020 were analyzed. ECGs at presentation to the emergency department were systematically read by electrophysiologists. The primary outcome was a composite of mechanical ventilation or death 48 hours from diagnosis. The prognostic value of ECG abnormalities was assessed in a model adjusted for demographics, comorbidities, and vital signs. Results At 48 hours, 73 patients (6%) had died and 174 (14%) were alive but receiving mechanical ventilation with 277 (22%) patients dying by 30 days. Early development of respiratory failure was common, with 53% of all intubations occurring within 48 hours of presentation. In a multivariable logistic regression, atrial fibrillation/flutter (OR 2.5, 95% CI [1.1-6.2]), right ventricular strain (OR 2.7, 95% CI [1.3-6.1]), and ST segment abnormalities (OR 2.4, 95% CI [1.5-3.8]) were associated with death or mechanical ventilation at 48 hours. In 108 patients without these ECG abnormalities and with normal respiratory vitals (rate <20 and saturation >95%), only 5 (5%) died or required mechanical ventilation by 48 hours versus 68 of 216 patients (31%) having both ECG and respiratory vital sign abnormalities. Conclusions The combination of abnormal respiratory vital signs and ECG findings of atrial fibrillation/flutter, right ventricular strain, or ST segment abnormalities accurately prognosticates early deterioration in patients with COVID-19 and may assist with patient triage. url: https://www.ncbi.nlm.nih.gov/pubmed/33012341/ doi: 10.1016/j.mayocp.2020.07.028 id: cord-356332-t0ahmh0h author: Elkattawy, Sherif title: A Rare Complication of Myocardial Infarction: Ventricular Septal Defect date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Ventricular septal defect (VSD) is a rare but lethal complication of myocardial infarction. We present a case of a 65-year-old male who presented with a history of progressive shortness of breath associated with productive cough. Physical examination was significant for crepitation in both lower lung fields and bilateral lower extremity edema. Chest X-ray revealed bilateral reticular opacities with small bilateral pleural effusions. Polymerase chain reaction (PCR) for COVID was positive. Echo showed a left ventricular ejection fraction (LVEF) of 30-35%, ischemic cardiomyopathy, and muscular ventricular septal defects with left to right shunting and severely elevated pulmonary artery systolic pressure. Overtime during the hospital course, he developed respiratory and fulminant hepatic failure. Our patient had VSD due to an undiagnosed old myocardial infarction (MI). Initially heart failure was compensated and treated with medical management. Later on, he developed respiratory complications related to COVID-19 infection as well as hepatic failure in addition to a cardiomyopathy which made him a poor surgical candidate leading to death. url: https://doi.org/10.7759/cureus.9725 doi: 10.7759/cureus.9725 id: cord-276641-40r4mitg author: Elkhouly, Enas A title: Should cancer treatment be continued during the COVID-19 pandemic? A single Egyptian institution experience date: 2020-07-23 words: 3109.0 sentences: 235.0 pages: flesch: 60.0 cache: ./cache/cord-276641-40r4mitg.txt txt: ./txt/cord-276641-40r4mitg.txt summary: The aim of this article is based on the fact that the potential threat of COVID-19 to immunocompromised cancer patients as a result of their disease or the treatment delivered is thought to be significant, so it is of great importance to study the best measures to be used by oncology centres to prevent or limit the exposure of cancer patients to COVID-19 and to provide cancer treatment to patients in need, as safely and as correctly as possible. After the appearance of COVID-19 in Egypt, it should be a must to take a rapid action by MCOD, until the arrival of national strategies from higher authorities, so the outpatients were classified into two groups: Group 1 patients under follow-up either as control or hormonal therapy (HT) and Group 2 patients under active treatments (surgery, chemotherapy (ChT), radiotherapy (RT), biological therapy or immunotherapy) either as neoadjuvant or adjuvant treatment or for metastatic disease. abstract: The first confirmed case of coronavirus disease 2019 (COVID-19) in Egypt was reported on 14 February, 2020. Menoufia Clinical Oncology Centre is at the forefront of delivering care to patients with cancer during this public health crisis in Menoufia Governorate, Egypt. This article highlights the unique circumstances and challenges of cancer treatment during this global pandemic and the importance of organisational structure, preparation and a shared vision for continuing to provide cancer treatment to patients in the face of uncertainty and rapid change. url: https://www.ncbi.nlm.nih.gov/pubmed/32863871/ doi: 10.3332/ecancer.2020.1077 id: cord-260762-1kuj5dzz author: Elledge, Christen R. title: Radiation therapy for gynecologic malignancies during the COVID-19 pandemic: International expert consensus recommendations date: 2020-06-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To develop expert consensus recommendations regarding radiation therapy for gynecologic malignancies during the COVID-19 pandemic. METHODS: An international committee of ten experts in gynecologic radiation oncology convened to provide consensus recommendations for patients with gynecologic malignancies referred for radiation therapy. Treatment priority groups were established. A review of the relevant literature was performed and different clinical scenarios were categorized into three priority groups. For each stage and clinical scenario in cervical, endometrial, vulvar, vaginal and ovarian cancer, specific recommendations regarding dose, technique, and timing were provided by the panel. RESULTS: Expert review and discussion generated consensus recommendations to guide radiation oncologists treating gynecologic malignancies during the COVID-19 pandemic. Priority scales for cervical, endometrial, vulvar, vaginal, and ovarian cancers are presented. Both radical and palliative treatments are discussed. Management of COVID-19 positive patients is considered. Hypofractionated radiation therapy should be used when feasible and recommendations regarding radiation dose, timing, and technique have been provided for external beam and brachytherapy treatments. Concurrent chemotherapy may be limited in some countries, and consideration of radiation alone is recommended. CONCLUSIONS: The expert consensus recommendations provide guidance for delivering radiation therapy during the COVID-19 pandemic. Specific recommendations have been provided for common clinical scenarios encountered in gynecologic radiation oncology with a focus on strategies to reduce patient and staff exposure to COVID-19. url: https://www.sciencedirect.com/science/article/pii/S0090825820323015?v=s5 doi: 10.1016/j.ygyno.2020.06.486 id: cord-274184-hm516x6p author: Elli, Luca title: Endoscopy during the Covid-19 outbreak: experience and recommendations from a single center in a high-incidence scenario date: 2020-04-27 words: 4843.0 sentences: 280.0 pages: flesch: 50.0 cache: ./cache/cord-274184-hm516x6p.txt txt: ./txt/cord-274184-hm516x6p.txt summary: From the abovementioned reasons we must deduce that: -in high SARS-CoV-2 incidence areas where PCR assays are not extensively performed, Covid-19 cannot be ruled out by simple clinical examination or epidemiological link; -the greatest amount of efforts and precautions are required to minimize the spread of the disease and to preserve medical staff from infection. In our current situation, which is characterized by high incidence of Covid-19 and relative scarcity of surveillance assays in asymptomatic subjects, for the abovementioned reasons we recommend different modalities of individual protection based on a strict clinical and epidemiological stratification of patients with potential SARS-CoV-2 infection undergoing endoscopic examination. In this setting, regardless of the classification of patients (high/low-risk, , in order to prevent the medical staff from becoming infected, we suggest high-performance personal protection equipment, i.e. a N95 or FFP2/FFP3 respirator, a hairnet, a double pair of gloves, a disposable waterproof surgical gown, a face shield (which we prefer because it allows to protect, and then spare, respirators) or goggles, and work safety clogs (Table 1) . abstract: A dramatic SARS-Cov-2 outbreak is hitting Italy hard. To face the new scenario all the hospitals have been re-organised in order to reduce all the outpatient services and to devote almost all their personnel and resources to the management of Covid-19 patients. As a matter of fact, all the services have undergone a deep re-organization guided by: the necessity to reduce exams, to create an environment that helps reduce the virus spread, and to preserve the medical personnel from infection. In these days a re-organization of the endoscopic unit, sited in a high-incidence area, has been adopted, with changes to logistics, work organization and patients selection. With the present manuscript, we want to support gastroenterologists and endoscopists in the organization of a “new” endoscopy unit that responds to the “new” scenario, while remaining fully aware that resources availability and local circumstances may extremely vary from unit to unit. url: https://www.sciencedirect.com/science/article/pii/S1590865820301730?v=s5 doi: 10.1016/j.dld.2020.04.018 id: cord-267041-i94lyfsh author: Ellner, Jerrold J. title: Management of acute and chronic respiratory tract infections date: 1988-09-16 words: 3288.0 sentences: 178.0 pages: flesch: 39.0 cache: ./cache/cord-267041-i94lyfsh.txt txt: ./txt/cord-267041-i94lyfsh.txt summary: ELLNER, M.D. Cleveland, CM Pharyngitis, bronchitis, and pneumonia represent the most common respiratory tract infections. Potentially pathogenic bacteria can be isolated in most sputum specimens from persons with chronic bronchitis, even in the absence of symptoms of acute infectious exacerbation, Although it is true that Streptococcus pneumoniae is isolated in increased quantities when patients experience exacerbation [Sl, it is not clear in the SYMPOSIUM ON CEFIXIME / ELLNER Determination of the Cause of Pneumonia * Is the current condition accurately termed "acute," or is it really chronic? Although the Gram''s stain may suggest that the cause of a pneumonia is not bacterial by the finding of inflammatory cells and no organisms, the clinical presentation can be even more useful for distinguishing a bacterial from a nonbacterial infection. The search for elastin fibers appears to be a generally useful adjunct for diagnosis not only in hospitalized patients but in all persons with pneumonia, particularly when symptoms do not fit the classic patterns of either bacterial or nonbacterial syndromes. abstract: Abstract Pharyngitis, bronchitis, and pneumonia represent the most common respiratory tract infections. With a view to establishing effective management strategies, the origins of these illnesses and the diagnostic techniques that have been developed to discover them are reviewed. Therapeutic regimens with documented efficacy are outlined with emphasis on specific rather than empiric treatment. Although many respiratory tract pathogens remain exquisitely sensitive to penicillin, the emergence of resistant strains underscores the need for safe and effective alternative therapies. url: https://www.sciencedirect.com/science/article/pii/0002934388904561 doi: 10.1016/0002-9343(88)90456-1 id: cord-035024-kx9jfssi author: Elmelhat, Ahmed title: Comparison between Prophylactic versus Therapeutic Doses of Low-Molecular-Weight Heparin in Severely Ill Coronavirus Disease 2019 Patients in Relation to Disease Progression and Outcome date: 2020-10-26 words: 3189.0 sentences: 158.0 pages: flesch: 49.0 cache: ./cache/cord-035024-kx9jfssi.txt txt: ./txt/cord-035024-kx9jfssi.txt summary: INTRODUCTION: The predominant coagulation abnormalities in patients with coronavirus disease 2019 (COVID-19) suggest a hypercoagulable state and are consistent with uncontrolled clinical observations of an increased risk of venous thromboembolism. CONCLUSION: Our results showed that use of prophylactic dose of enoxaparin might have some benefits compared to the therapeutic dose in terms of less duration of ICU and hospital stay, duration of oxygen support, need and duration of MV, and normalization of inflammatory markers. There was a significant difference between both study groups in enoxaparin duration, time to ferritin and Ddimer improvement, and the duration of MV and O 2 support duration, with longer duration among group 2 cases (therapeutic dose) compared to group 1 (prophylactic dose) in all the above-mentioned variables. Our study compared the effect of different dose regimens of the anticoagulant enoxaparin (prophylactic and therapeutic) that was administered to patients with severe COVID-19 infection, and we compared the clinical outcome as well as improvement in laboratory parameters in both groups. abstract: INTRODUCTION: The predominant coagulation abnormalities in patients with coronavirus disease 2019 (COVID-19) suggest a hypercoagulable state and are consistent with uncontrolled clinical observations of an increased risk of venous thromboembolism. AIM AND OBJECTIVES: To compare the effect of prophylactic versus therapeutic doses of enoxaparin in the treatment of severe cases of COVID-19 infection. MATERIALS AND METHODS: This was a retrospective observational study conducted at Latifa hospital, Dubai. Fifty-nine patients enrolled from March to June 2020 and divided into 2 groups: patients who received the prophylactic dose of enoxaparin (group 1) and patients who received the therapeutic dose of enoxaparin (group 2). RESULTS: The mean age of all cases was 47.2 ± 10.4 years, while the mean weight was 76.4 ± 13.4 kg. Males represented 79.7% of cases. Blood group “O” was the most frequent blood group (40.9%). None of the cases were smokers or using alcohol. Bronchial asthma, lung diseases, diabetes mellitus, hypertension, CKD, cardiac disease, thyroid disease, and immunodeficiency were present in 1.7, 1.7, 39, 27.1, 5.1, 1.7, 5.1, and 1.7% respectively. There was no significant difference between both study groups regarding personal and medical characteristics, except for hypertension where 35.9% of group 2 (therapeutic) cases were hypertensive compared to 10% of group 1 cases (prophylactic). There was a significant difference between both study groups regarding inflammatory markers improvement duration, duration of MV and O2 support duration, with longer duration among (therapeutic) group 2 cases compared to group 1 cases (prophylactic). There was a highly significant difference between both study groups regarding ICU admission, as 64% of group 1 cases were admitted compared to 25% of group 1 cases. Similarly, 38.5% of group 2 cases needed MV compared to only 10% of group 1 cases, which was statistically significant. There was no significant difference between both groups regarding bleeding tendency and mortality (p value 0.54). CONCLUSION: Our results showed that use of prophylactic dose of enoxaparin might have some benefits compared to the therapeutic dose in terms of less duration of ICU and hospital stay, duration of oxygen support, need and duration of MV, and normalization of inflammatory markers. However, there was no significant difference between the 2 regimens regarding the mortality. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649681/ doi: 10.1159/000511163 id: cord-284175-5rre1kbn author: Elsaid, Ossama title: Ventricular Fibrillation Storm in Coronavirus 2019 date: 2020-08-29 words: 1089.0 sentences: 87.0 pages: flesch: 37.0 cache: ./cache/cord-284175-5rre1kbn.txt txt: ./txt/cord-284175-5rre1kbn.txt summary: Herein, we describe the clinical course of an otherwise healthy patient who experienced persistent ventricular tachycardia and fibrillation which is believed to be directly related to inflammation, as opposed to acute myocardial injury or medications that can prolong the QT interval. One study reported ventricular tachycardia (VT)/VF in 5.9% (11/187) of COVID-19 patients (Table 2 3-9 ), with elevated troponin-T increasing risk, suggesting that myocardial injury precipitates arrhythmia 2 . Tocilizumab was shown to have a robust shortening of the QTc prolongation induced by abundant inflammatory cytokines in patients with acute rheumatoid arthritis 16 . As such, this report suggests that the hyper-inflammatory state in COVID-19 patients can induce ventricular arrhythmias, which may cease abruptly following a reduction in inflammation, in our case from convalescent serum and/or hydrocortisone therapy. QT interval prolongation and torsade de pointes in patients with COVID-19 treated with hydroxychloroquine/azithromycin abstract: Cardiac arrhythmia is a known manifestation of novel coronavirus 2019 (COVID-19) infection. Herein, we describe the clinical course of an otherwise healthy patient who experienced persistent ventricular tachycardia and fibrillation which is believed to be directly related to inflammation, as opposed to acute myocardial injury or medications that can prolong the QT interval. url: https://www.sciencedirect.com/science/article/pii/S0002914920308900?v=s5 doi: 10.1016/j.amjcard.2020.08.033 id: cord-299681-smhto9em author: Elsaie, Mohamed L. title: Herpes zoster might be an indicator for Latent COVID 19 infection date: 2020-05-23 words: 691.0 sentences: 49.0 pages: flesch: 54.0 cache: ./cache/cord-299681-smhto9em.txt txt: ./txt/cord-299681-smhto9em.txt summary: In this report we describe two cases COVID infection who first presented with herpes zoster. We are here by suggesting that the clinical presentation of HZ at the time of the current pandemic even in patients giving mild or no suggestive history of upper respiratory symptoms should be considered as an alarming sign for a recent subclinical SARS CoV2 infection. Most patients with COVID-19 exhibit mild to moderate symptoms, but approximately 15% of the cases progress to severe pneumonia and about 5% eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure (3, 4) . We present two cases of clinically diagnosed Herpes zoster infection attending two different clinics, both patients'' showed no or mild symptoms of COVID 19 infection and denied any history of contact with known or suspected COVID19 cases. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan abstract: Various cutaneous manifestations have been observed in patients with COVID‐19 infection. Herpes Zoster is a viral skin disease caused by varicella zoster that remains dormant in the dorsal root ganglia of cutaneous nerves following a primary chicken pox infection. In this report we describe two cases COVID infection who first presented with herpes zoster. We are here by suggesting that the clinical presentation of HZ at the time of the current pandemic even in patients giving mild or no suggestive history of upper respiratory symptoms should be considered as an alarming sign for a recent subclinical SARS CoV2 infection. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1111/dth.13666 doi: 10.1111/dth.13666 id: cord-260180-kojb8efv author: Elsoukkary, Sarah S. title: Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience date: 2020-09-17 words: 4600.0 sentences: 269.0 pages: flesch: 49.0 cache: ./cache/cord-260180-kojb8efv.txt txt: ./txt/cord-260180-kojb8efv.txt summary: METHODS: We report the clinicopathologic findings from 32 autopsy studies conducted on patients who died of COVID-19 including routine gross and microscopic examination with applicable special and immunohistochemical staining techniques. The purpose of this study is to describe clinical and pathologic findings in major organ systems of patients who died from SARS-CoV-2 infection. In this study, we described the unique and multisystem clinical and pathologic findings in 32 autopsies of patients who died from the novel coronavirus, SARS-CoV-2. On histologic examination, we observed findings secondary to the patients'' preexisting conditions in the heart, lungs, liver, and kidneys, as well as changes secondary to SARS-CoV-2 infection such as various stages of DAD and multiple thromboemboli in large and small vessels in multiple organs. While the lung findings are most significant for the majority of those infected, other organ systems are frequently involved including with widespread microscopic thromboses in numerous organs, as well as liver, kidney, and lymph node pathology. abstract: BACKGROUND: A novel coronavirus, SARS-CoV-2, was identified in Wuhan, China in late 2019. This virus rapidly spread around the world causing disease ranging from minimal symptoms to severe pneumonia, which was termed coronavirus disease (i.e., COVID). Postmortem examination is a valuable tool for studying the pathobiology of this new infection. METHODS: We report the clinicopathologic findings from 32 autopsy studies conducted on patients who died of COVID-19 including routine gross and microscopic examination with applicable special and immunohistochemical staining techniques. RESULTS: SARS-CoV-2 infection was confirmed by nasopharyngeal RT-PCR in 31 cases (97%) and by immunohistochemical staining for SARS-CoV-2 spike-protein in the lung in the remaining 1 case (3%). The ethnically diverse cohort consisted of 22 males and 10 females with a mean age of 68 years (range: 30–100). Patients most commonly presented with cough (17 [55%]), shortness of breath (26 [81%]), and a low-grade fever (17 [55%]). Thirty-one (97%) of the patients had at least 1 comorbidity (mean = 4). Twenty-eight patients (88%) had widespread thromboembolic disease, as well as diffuse alveolar damage (30 [94%]), diabetic nephropathy (17 [57%]) and acute tubular injury. Patterns of liver injury were heterogeneous, featuring 10 (36%) with frequent large basophilic structures in sinusoidal endothelium, and increased immunoblast-like cells in lymph nodes. CONCLUSION: This series of autopsies from patients with COVID-19 confirms the observation that the majority of severely affected patients have significant pulmonary pathology. However, many patients also have widespread microscopic thromboses, as well as characteristic findings in the liver and lymph nodes. url: https://doi.org/10.1159/000511325 doi: 10.1159/000511325 id: cord-267357-7aap2cte author: Elston, Dirk M. title: The coronavirus (COVID-19) epidemic and patient safety date: 2020-02-16 words: 604.0 sentences: 46.0 pages: flesch: 44.0 cache: ./cache/cord-267357-7aap2cte.txt txt: ./txt/cord-267357-7aap2cte.txt summary: title: The coronavirus (COVID-19) epidemic and patient safety The coronavirus (COVID-19) epidemic and patient safety Dirk M. Elston, MD Charleston, South Carolina I n this issue of the JAAD, Chen et al 1 discuss patient safety measures in a Chinese dermatology clinic during the coronavirus outbreak (2019-nCoV acute respiratory disease), including patient screening, respiratory precautions, and telemedicine consultations. 2, 3 Large health care organizations often address these issues during in-processing of employees, but many dermatologists practice in private clinics and should review existing policies to prepare for the inevitability of contagious patients entering the clinic. Prior outbreaks of virulent coronavirus strains have also been associated with severe respiratory syndromes and patient deaths. 4 Our responsibility for patient and employee safety is not limited to respiratory pathogens. Prevention of transmission of blood-borne infections deserves special mention, and readers should review the JAAD continuing medical education articles that focused on patient safety and blood-borne pathogens (https://www.jaad. abstract: nan url: https://api.elsevier.com/content/article/pii/S0190962220302693 doi: 10.1016/j.jaad.2020.02.031 id: cord-005795-sgi54hq8 author: Ely, E. title: The impact of delirium in the intensive care unit on hospital length of stay date: 2001-11-08 words: 4876.0 sentences: 217.0 pages: flesch: 40.0 cache: ./cache/cord-005795-sgi54hq8.txt txt: ./txt/cord-005795-sgi54hq8.txt summary: Patients in the intensive care unit (ICU) are at very high risk for the development of delirium due to factors such as multi-system illnesses and comorbidities, the use of psychoactive medications, and age. While recent studies have selected delirium and pharmacologic issues (which are inter-related) as two of the top three most important target areas for quality of care improvement in vulnerable older adults [13] , nearly all delirium investigations have excluded medical ICU patients who are often receiving prolonged sedation on mechanical ventilators [1, 2, 14, 15, 16, 17] . Two study nurses enrolled patients each morning and recorded baseline demographics, severity of illness data using the Acute Physiology and Chronic Health Evaluation (APACHE) II score [21] , activities of daily living [22] , and risk factors for delirium derived from data in the literature [2, 3, 14, 15, 23, 24, 25, 26, 27] . abstract: Study objective: To determine the relationship between delirium in the intensive care unit (ICU) and outcomes including length of stay in the hospital. Design: A prospective cohort study. Setting: The adult medical ICU of a tertiary care, university-based medical center. Participants: The study population consisted of 48 patients admitted to the ICU, 24 of whom received mechanical ventilation. Measurements: All patients were evaluated for the development and persistence of delirium on a daily basis by a geriatric or psychiatric specialist with expertise in delirium assessment using the Diagnostic Statistical Manual IV (DSM-IV) criteria of the American Psychiatric Association, the reference standard for delirium ratings. Primary outcomes measured were length of stay in the ICU and hospital. Results: The mean onset of delirium was 2.6 days (S.D.±1.7), and the mean duration was 3.4±1.9 days. Of the 48 patients, 39 (81.3%) developed delirium, and of these 29 (60.4%) developed the complication while still in the ICU. The duration of delirium was associated with length of stay in the ICU (r=0.65, P=0.0001) and in the hospital (r=0.68, P<0.0001). Using multivariate analysis, delirium was the strongest predictor of length of stay in the hospital (P=0.006) even after adjusting for severity of illness, age, gender, race, and days of benzodiazepine and narcotic drug administration. Conclusions: In this patient cohort, the majority of patients developed delirium in the ICU, and delirium was the strongest independent determinant of length of stay in the hospital. Further study and monitoring of delirium in the ICU and the risk factors for its development are warranted. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095464/ doi: 10.1007/s00134-001-1132-2 id: cord-355177-62v1qhia author: Emery, Andrew Robert title: A Novel Approach to Fiberoptic Intubation in COVID-19 Patients date: 2020-07-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has created a strain on the healthcare workforce and industrial supply chains of personal protective equipment (PPE). In response, efforts have shifted to alternative methods to protect patients and healthcare providers. Several patient isolation hood designs have been proposed to reduce the risk of aerosolization during endotracheal intubation. However, oral and maxillofacial surgery commonly involves in patients with difficult airways that require fiberoptic intubation (FOI), which is not well suited for current hood designs. In this manuscript, we describe a negative-pressure intubation hood (NPIH) designed for fiberoptic intubation, which contains aerosols of the patient and better protects healthcare workers who are present at the time of intubation and extubation on oral and maxillofacial surgery cases. url: https://www.sciencedirect.com/science/article/pii/S0278239120307795?v=s5 doi: 10.1016/j.joms.2020.07.027 id: cord-336423-rs4bma9b author: Endersby, Ryan Vincent William title: Barrier Devices for Reducing Aerosol and Droplet Transmission in Coronavirus Disease 2019 Patients: Advantages, Disadvantages, and Alternative Solutions date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33031686/ doi: 10.1213/ane.0000000000004953 id: cord-016814-tf17dpo5 author: Enes, Sara Rolandsson title: Clinical Application of Stem/Stromal Cells in COPD date: 2019-08-07 words: 10751.0 sentences: 521.0 pages: flesch: 40.0 cache: ./cache/cord-016814-tf17dpo5.txt txt: ./txt/cord-016814-tf17dpo5.txt summary: Despite increasing number of preclinical studies demonstrating that systemic MSC administration can prevent or treat experimental COPD and emphysema, clinical studies have not been able to reproduce the preclinical results and to date no efficacy or significantly improved lung function or quality of life has been observed in COPD patients. performed a Phase I, prospective, open-label study (NCT01306513) where they aimed to assess the safety and feasibility of intravenously infused bone marrow-derived MSCs for ten patients with severe emphysema that had serial lung volume reduction surgeries (LVRS). Current clinical trials that aimed to evaluate the effect of MSC administration in COPD patients differ in a wide range of factors such as routes of administration, number of MSC administered, number of administrations, use of fresh MSCs or culture-expanded MSCs. Furthermore, all the investigations discussed above, were phase I-II studies that were underpowered in order to detect potential efficacy and no improved pulmonary function or respiratory quality of life was observed. abstract: Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies provide a platform for the development of new therapeutic approaches in severe lung diseases such as COPD. At present, a lot of focus is on mesenchymal stem (stromal) cell (MSC)-based therapies, mainly due to their immunomodulatory properties. Despite increasing number of preclinical studies demonstrating that systemic MSC administration can prevent or treat experimental COPD and emphysema, clinical studies have not been able to reproduce the preclinical results and to date no efficacy or significantly improved lung function or quality of life has been observed in COPD patients. Importantly, the completed appropriately conducted clinical trials uniformly demonstrate that MSC treatment in COPD patients is well tolerated and no toxicities have been observed. All clinical trials performed so far, have been phase I/II studies, underpowered for the detection of potential efficacy. There are several challenges ahead for this field such as standardized isolation and culture procedures to obtain a cell product with high quality and reproducibility, administration strategies, improvement of methods to measure outcomes, and development of potency assays. Moreover, COPD is a complex pathology with a diverse spectrum of clinical phenotypes, and therefore it is essential to develop methods to select the subpopulation of patients that is most likely to potentially respond to MSC administration. In this chapter, we will discuss the current state of the art of MSC-based cell therapy for COPD and the hurdles that need to be overcome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121219/ doi: 10.1007/978-3-030-29403-8_6 id: cord-285732-xew5ar1e author: Eperjesiova, Bianka title: Spontaneous Pneumomediastinum/Pneumothorax in Patients With COVID-19 date: 2020-07-03 words: 799.0 sentences: 58.0 pages: flesch: 46.0 cache: ./cache/cord-285732-xew5ar1e.txt txt: ./txt/cord-285732-xew5ar1e.txt summary: No spontaneous air leak case series have been described in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patient population thus far. We described seven spontaneous air leak cases we found in our coronavirus disease 2019 (COVID-19) positive 976-patient cohort. Air leak in hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients has been sparsely published as case reports, however, the presence of non-invasive ventilation and positive airway pressure were reported prior to this finding [3] [4] . Studies of a severe acute respiratory syndrome with SARS did identify air leak as a frequent complication, often with no relation to intubation or positive pressure ventilation [1] [2] [3] [4] [5] . Of these, we found 20 cases of air leak; three traumatic/post-procedure, 10 post-intubation/mechanical ventilation, and seven spontaneous (five cases of pneumomediastinum and two isolated pneumothorax). One out of seven spontaneous air leak patients expired. Spontaneous pneumomediastinum in patients with severe acute respiratory syndrome abstract: No spontaneous air leak case series have been described in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patient population thus far. We described seven spontaneous air leak cases we found in our coronavirus disease 2019 (COVID-19) positive 976-patient cohort. Five out of seven patients eventually required mechanical ventilation, and one of these patients died. All of our patients who demonstrated radiological air leaks after intubation died. No other precipitating factors offered in the literature thus far played a role in our patient population. We presume that acute lung injury leading to SARS-CoV-2 with associated acute respiratory distress syndrome (ARDS) predisposes patients to this rare complication. url: https://www.ncbi.nlm.nih.gov/pubmed/32642391/ doi: 10.7759/cureus.8996 id: cord-317566-6ch6na31 author: Epstein, Robert S. title: Patient Burden and Real-World Management of Chemotherapy-Induced Myelosuppression: Results from an Online Survey of Patients with Solid Tumors date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Chemotherapy-induced myelosuppression (CIM) is one of the most common dose-limiting complications of cancer treatment, and is associated with a range of debilitating symptoms that can significantly impact patients’ quality of life. The purpose of this study was to understand patients’ perspectives on how the side effects of CIM are managed in routine clinical practice. METHODS: An online survey was conducted of participants with breast, lung, or colorectal cancer who had received chemotherapy treatment within the past 12 months, and had experienced at least one episode of myelosuppression in the past year. The survey was administered with predominantly close-ended questions, and lay definitions of key terms were provided to aid response selection. RESULTS: Of 301 participants who completed the online survey, 153 (51%) had breast cancer, 100 (33%) had lung cancer, and 48 (16%) had colorectal cancer. Anemia, neutropenia, lymphopenia, and thrombocytopenia were reported by 61%, 59%, 37%, and 34% of participants, respectively. Most participants (79%) reported having received treatment for CIM, and 64% of participants recalled chemotherapy dose modifications as a result of CIM. Although most participants believed their oncologist was aware of the side effects of CIM, and treated them quickly, 30% of participants felt their oncologists did not understand how uncomfortable they were due to the side effects of CIM. Overall, 88% of participants considered CIM to have a moderate or major impact on their lives. CONCLUSION: The data highlight that despite the various methods used to address CIM, and the patient-focused approach of oncologists, the real-world impact of CIM on patients is substantial. Improving communication between patients and health care providers may help improve patients’ understanding of CIM, and foster shared decision-making in terms of treatment. Additional insights from patients should be obtained to further elucidate the totality of life burden associated with CIM. url: https://www.ncbi.nlm.nih.gov/pubmed/32642965/ doi: 10.1007/s12325-020-01419-6 id: cord-311043-nidu7om2 author: Erdinc, Burak title: Spontaneous Retroperitoneal Bleed Coincided With Massive Acute Deep Vein Thrombosis as Initial Presentation of COVID-19 date: 2020-08-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic and unfortunately has caused a health crisis. When severe, coronavirus disease 2019 (COVID-19) can manifest with bilateral pneumonia and hypoxemic respiratory failure but also can affect different organ systems. SARS-CoV-2 infection is known to cause a hypercoagulable state resulting in acute thrombotic events, including venous thromboembolism, acute myocardial infarction, acute stroke, acute limb ischemia, and clotting of ECMO (extracorporeal membrane oxygenation) and CRRT (continuous renal replacement therapy) catheters. Even though it commonly causes thrombotic complications, bleeding complications of COVID-19 due to coagulopathy and use of anticoagulation are less commonly reported. We herein present a case of a patient with COVID-19 complicated by spontaneous retroperitoneal bleeding and massive deep vein thrombosis (DVT), which was later complicated by compartment syndrome. To the best of our knowledge, coexistence of spontaneous bleeding with massive DVT has not been reported in the current literature. This case emphasizes that COVID-19 induced hypercoagulable state can cause massive thrombosis, and patients might need anticoagulation therapy. However, clinicians should also consider the risk of hemorrhagic complications of the disease and be cautious when administering anticoagulant therapy in selected cases. url: https://www.ncbi.nlm.nih.gov/pubmed/32953290/ doi: 10.7759/cureus.9772 id: cord-353256-7nfklun9 author: Eroglu‐Ertugrul, Nesibe Gevher title: The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children date: 2019-11-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To demonstrate the value of flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) when determining causes of lung infection in immunocompromised children; to investigate differences in causes and radiological features of lung infections following bone marrow transplantation (BMT) compared to other immunosuppressive conditions; to evaluate the reliability of radiological findings when predicting the pathogen. METHODS: We retrospectively evaluated 132 immunosuppressed children who underwent FB and BAL because pulmonary complications between January 1999 and May 2014 at the Hacettepe University Hospital Pediatric Pulmonology Unit. Two groups, Group I (n = 106) and Group II (n = 26), consisted of patients who had primary or secondary immunodeficiency and those who were immunosuppressed because BMT, respectively. Radiological findings before FB and macroscopic and microscopic findings of the procedure were evaluated. RESULTS: FB and BAL were diagnostic in 86/132 patients (65.1%) and the antimicrobial treatment changed for 75/132 patients (56.8%). The most common pathogen was bacteria (Streptococcus pneumoniae was the leading one). Bacteria were more frequent in Group I than Group II (P = .008). No significant difference in radiological findings between Groups I and II was found. Considering all patients, a significant association was detected between viral pathogens and radiologically interstitial infiltration and a ground‐glass appearance (P = .003). However, no significant association was detected between bacterial and fungal pathogens and the radiological findings. CONCLUSION: In immunosuppressed patients, FB and BAL should be evaluated early for clarifying the causative agents. Then, appropriate treatments can be utilised and the side effects and high cost of unnecessary treatment may be mitigated. url: https://www.ncbi.nlm.nih.gov/pubmed/31710418/ doi: 10.1111/crj.13103 id: cord-266932-567lbktm author: Escalard, Simon title: Early Brain Imaging Shows Increased Severity of Acute Ischemic Strokes With Large Vessel Occlusion in COVID-19 Patients date: 2020-08-19 words: 1439.0 sentences: 78.0 pages: flesch: 47.0 cache: ./cache/cord-266932-567lbktm.txt txt: ./txt/cord-266932-567lbktm.txt summary: title: Early Brain Imaging Shows Increased Severity of Acute Ischemic Strokes With Large Vessel Occlusion in COVID-19 Patients METHODS: We performed a comparative cohort study between patients with COVID-19 who had anterior circulation large vessel occlusion and early brain imaging within 3 hours from onset, in our institution during the 6 first weeks of the COVID-19 outbreak and a control group admitted during the same calendar period in 2019. Patients with COVID-19 had more severe strokes than patients without COVID-19, with a significantly lower clot burden score (median: 6.5 versus 8, P=0.016), higher rate of multivessel occlusion (50% versus 8.8%, P=0.005), lower DWI-ASPECTS (Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores; median: 5 versus 8, P=0.006), and higher infarct core volume (median: 58 versus 6 mL, P=0.004). CONCLUSIONS: Early brain imaging showed higher severity large vessel occlusion strokes in patients with COVID-19. Early brain imaging showed higher severity of anterior circulation large vessel occlusion strokes in patients with COVID-19. abstract: BACKGROUND AND PURPOSE: Reports are emerging regarding the association of acute ischemic strokes with large vessel occlusion and coronavirus disease 2019 (COVID-19). While a higher severity of these patients could be expected from the addition of both respiratory and neurological injury, COVID-19 patients with strokes can present with mild or none respiratory symptoms. We aimed to compare anterior circulation large vessel occlusion strokes severity between patients with and without COVID-19. METHODS: We performed a comparative cohort study between patients with COVID-19 who had anterior circulation large vessel occlusion and early brain imaging within 3 hours from onset, in our institution during the 6 first weeks of the COVID-19 outbreak and a control group admitted during the same calendar period in 2019. RESULTS: Twelve COVID-19 patients with anterior circulation large vessel occlusion and early brain imaging were included during the study period and compared with 34 control patients with anterior circulation large vessel occlusion and early brain imaging in 2019. Patients in the COVID-19 group were younger (P=0.032) and had a history of diabetes mellitus more frequently (P=0.039). Patients did not significantly differ on initial National Institutes of Health Stroke Scale nor time from onset to imaging (P=0.18 and P=0.6, respectively). Patients with COVID-19 had more severe strokes than patients without COVID-19, with a significantly lower clot burden score (median: 6.5 versus 8, P=0.016), higher rate of multivessel occlusion (50% versus 8.8%, P=0.005), lower DWI-ASPECTS (Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores; median: 5 versus 8, P=0.006), and higher infarct core volume (median: 58 versus 6 mL, P=0.004). Successful recanalization rate was similar in both groups (P=0.767). In-hospital mortality was higher in the COVID-19 patients’ group (41.7% versus 11.8%, P=0.025). CONCLUSIONS: Early brain imaging showed higher severity large vessel occlusion strokes in patients with COVID-19. Given the massive number of infected patients, concerns should be raised about the coming neurovascular impact of the pandemic worldwide. url: https://www.ncbi.nlm.nih.gov/pubmed/32813602/ doi: 10.1161/strokeaha.120.031011 id: cord-262954-saqo900k author: Esme, Mert title: Older Adults With Coronavirus Disease 2019; A Nationwide Study in Turkey date: 2020-09-01 words: 4857.0 sentences: 305.0 pages: flesch: 59.0 cache: ./cache/cord-262954-saqo900k.txt txt: ./txt/cord-262954-saqo900k.txt summary: In this study we aimed to describe the clinical characteristics and outcomes of hospitalized older adults with coronavirus disease 2019 (COVID-19) in Turkey. Through multivariate analysis of the causes of death in older patients, we found that male gender, diabetes mellitus, heart failure, chronic kidney disease, dementia, cancer, admission to intensive care unit, computed tomography finding compatible with COVID-19 were all significantly associated with mortality in entire cohort. The Centers for Disease Control and Prevention (CDC) reported that individuals older than age 65 comprise 17% of the total population in the United States, though they are responsible for 31% of infections, 45% of hospitalizations, 53% of intensive care unit (ICU) admissions and 80% of deaths caused by . Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study abstract: BACKGROUND: A novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) occurred in China in December 2019 and has spread globally. In this study we aimed to describe the clinical characteristics and outcomes of hospitalized older adults with coronavirus disease 2019 (COVID-19) in Turkey. METHODS: We retrospectively analyzed the clinical data of hospitalized patients aged ≥ 60 years with confirmed COVID-19 from March 11, 2020, to May 27, 2020 using nationwide health database. RESULTS: In this nationwide cohort, a total of 16942 hospitalized older adults with COVID-19 were enrolled, of whom 8635 (51%) were women. Mean age was 71.2 ± 8.5 years, ranging from 60 to 113 years. Mortality rate before and after curfew was statistically different (32.2% vs 17.9%; p & 0.001, respectively). Through multivariate analysis of the causes of death in older patients, we found that male gender, diabetes mellitus, heart failure, chronic kidney disease, dementia, cancer, admission to intensive care unit, computed tomography finding compatible with COVID-19 were all significantly associated with mortality in entire cohort. In addition to abovementioned risk factors, in patients aged between 60-79 years, coronary artery disease, oxygen support need, total number of drugs, and cerebrovascular disease during hospitalization, and in patients 80 years of age and older acute coronary syndrome during hospitalization were also associated with increased risk of mortality. CONCLUSIONS: In addition to the results of previous studies with smaller sample size, our results confirmed the age-related relationship between specific comorbidities and COVID-19 related mortality. url: https://doi.org/10.1093/gerona/glaa219 doi: 10.1093/gerona/glaa219 id: cord-286607-5i406twr author: Esposito, Susanna title: The Gut Microbiota-Host Partnership as a Potential Driver of Kawasaki Syndrome date: 2019-04-05 words: 6223.0 sentences: 250.0 pages: flesch: 30.0 cache: ./cache/cord-286607-5i406twr.txt txt: ./txt/cord-286607-5i406twr.txt summary: Kawasaki syndrome (KS) is a necrotizing vasculitis of smalland medium-sized vessels mostly affecting children under 5 years of age; a host of clinical and epidemiological data supports the notion that KS might result from an infectious disease. All studies available to date have confirmed that an imbalance in the gut microbiota might indirectly interfere with the normal function of innate and adaptive immunity, and that variable microbiota interactions with environmental factors, mainly infectious agents, might selectively drive the development of KS in genetically susceptible children. The microbiota, a microbial community of trillions of microorganisms and at least 1,000 different bacterial species, some eukaryotic fungi and viruses, and which covers every surface of the human body, plays a contributory role in many infections, immune-mediated disorders, rheumatologic diseases, and disorders of the nervous system. abstract: Kawasaki syndrome (KS) is a necrotizing vasculitis of small- and medium-sized vessels mostly affecting children under 5 years of age; a host of clinical and epidemiological data supports the notion that KS might result from an infectious disease. However, many efforts have failed to identify a potentially universal trigger of KS. The contribution of the intestinal microbial community—called the “microbiota”—to KS has been evaluated by an increasing number of studies, though limited to small cohorts of patients. Differences in the microbiota composition were found in children with KS, both its acute and non-acute phase, with abnormal colonization by Streptococcus species in the intestinal tract and a wider presence of Gram-positive cocci in jejunal biopsies. In particular, a higher number of Gram-positive cocci (of the genera Streptococcus and Staphylococcus), Eubacterium, Peptostreptococcus, and HSP60-producing Gram-negative microbes have been found in the stools of KS children, and their effects on the antigenic repertoire of specific T cells and Vβ2 T cell expansion have been assessed. Conversely, Lactobacilli were lacking in most children with KS compared with other febrile illnesses and healthy controls. All studies available to date have confirmed that an imbalance in the gut microbiota might indirectly interfere with the normal function of innate and adaptive immunity, and that variable microbiota interactions with environmental factors, mainly infectious agents, might selectively drive the development of KS in genetically susceptible children. Further investigations of the intestinal microflora in larger cohorts of KS patients will provide clues to disentangle the pathogenesis of this disease and probably indicate disease-modifying agents or more rational KS-specific therapies. url: https://www.ncbi.nlm.nih.gov/pubmed/31024869/ doi: 10.3389/fped.2019.00124 id: cord-310597-zy6ckr53 author: Essa, Hani title: Hypertension management in cardio-oncology date: 2020-08-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Cancer is one of the leading causes of death worldwide. During the last few decades prognosis has improved dramatically and patients are living longer and suffering long-term cardiovascular consequences of chemotherapeutic agents. Cardiovascular disease is a leading cause of morbidity and mortality in cancer survivors second only to recurrent cancer. In some types of cancer, cardiovascular disease is a more common cause of death than the cancer itself. This has led to a new sub-specialty of cardiology coined cardio-oncology to manage this specific population. Hypertension is one of the most common cardiovascular disease seen in this cohort. The aetiology of hypertension in cardio-oncology is complex and multifactorial based on the type of chemotherapy, type of malignancy and intrinsic patient factors such as age and pre-existing comorbidities. A variety of different oncological treatments have been implicated in causing hypertension. The effect can be transient whilst undergoing treatment or can be delayed occurring decades after treatment. A tailored management plan is recommended given the plethora of agents and their differing underlying mechanisms and speed of this mechanism in causing hypertension. Management by a multidisciplinary team consisting of oncology, general practice and cardiology is advised. There are currently no trials comparing antihypertensives in this specific cohort of patients. In the absence of evidence demonstrating otherwise, hypertension in cardio-oncology should be managed utilising the same treatment guidelines for the general population. url: https://www.ncbi.nlm.nih.gov/pubmed/32747676/ doi: 10.1038/s41371-020-0391-8 id: cord-277399-0w8is9xm author: Esteves, Sandro C. title: SARS‐CoV‐2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services date: 2020-05-22 words: 4160.0 sentences: 216.0 pages: flesch: 38.0 cache: ./cache/cord-277399-0w8is9xm.txt txt: ./txt/cord-277399-0w8is9xm.txt summary: The prolonged lockdown of health facilities providing non‐urgent gamete cryopreservation—as currently recommended by many reproductive medicine entities and regulatory authorities due to the SARS‐CoV‐2 pandemic will be detrimental for subgroups of male infertility patients. These groups include infertility patients (eg, azoospermic and cryptozoospermic) undergoing medical or surgical treatment to improve sperm quantity and quality, as well as males of reproductive age affected by inflammatory and systemic auto‐immune diseases who are about to start treatment with gonadotoxic drugs or who are under remission. Sperm banking should be considered in men with HH who respond to therapy, that is, have viable spermatozoa in the ejaculate, in particular, when the continuation of gonadotropin therapy during the SARS-CoV-2 pandemic is neither possible (eg, due to economic or logistic reasons), nor desired. We propose remedies to mitigate the consequences of a prolonged cessation of andrological services due to the SARS-CoV-2 pandemic to vulnerable subgroups of male infertility patients. abstract: The prolonged lockdown of health facilities providing non‐urgent gamete cryopreservation—as currently recommended by many reproductive medicine entities and regulatory authorities due to the SARS‐CoV‐2 pandemic will be detrimental for subgroups of male infertility patients. We believe the existing recommendations should be promptly modified and propose that the same permissive approach for sperm banking granted for men with cancer is expanded to other groups of vulnerable patients. These groups include infertility patients (eg, azoospermic and cryptozoospermic) undergoing medical or surgical treatment to improve sperm quantity and quality, as well as males of reproductive age affected by inflammatory and systemic auto‐immune diseases who are about to start treatment with gonadotoxic drugs or who are under remission. In both scenarios, the “fertility window” may be transitory; postponing diagnostic semen analysis and sperm banking in these men could compromise the prospects of biological parenthood. Moreover, we provide recommendations on how to continue the provision of andrological services in a considered manner and a safe environment. Our opinion is timely and relevant given the fact that fertility services are currently rated as of low priority in most countries. url: https://www.ncbi.nlm.nih.gov/pubmed/32357288/ doi: 10.1111/andr.12809 id: cord-341670-o1v63zg8 author: Estevez-Ordonez, Dagoberto title: Letter: Perioperative and Critical Care Management of a Patient With Severe Acute Respiratory Syndrome Corona Virus 2 Infection and Aneurysmal Subarachnoid Hemorrhage date: 2020-05-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/neuros/nyaa197 doi: 10.1093/neuros/nyaa197 id: cord-330870-l0ryikhv author: Eubanks, Allison title: Obstetric Simulation for a Pandemic date: 2020-07-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: In the middle of the COVID-19 pandemic, guidelines and recommendations are rapidly evolving. Providers strive to provide safe high-quality care for their patients in the already high-risk specialty of Obstetrics while also considering the risk that this virus adds to their patients and themselves. From other pandemics, evidence exists that simulation is the most effective way to prepare teams, build understanding and confidence, and increase patient and provider safety. FINDING: Practicing in-situ multidisciplinary simulations in the hospital setting has illustrated key opportunities for improvement that should be considered when caring for a patient with possible COVID-19. CONCLUSION: In the current COVID-19 pandemic, simulating obstetrical patient care from presentation to the hospital triage through postpartum care can prepare teams for even the most complicated patients while increasing their ability to protect themselves and their patients. url: https://api.elsevier.com/content/article/pii/S014600052030077X doi: 10.1016/j.semperi.2020.151294 id: cord-257276-h5542vqg author: Euchi, Jalel title: A Hybrid Approach to Solve the Vehicle Routing Problem with Time Windows and Synchronized Visits In-Home Health Care date: 2020-08-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: With technological progress in particular telemedicine and health care, the information should meet and serve as well the needs of people and in particular whom with reduced mobility, the elderly as well as people with difficulties to access to medical resources and services. These services should be achieved in a fast and reliable manner based on case priorities. One of the major challenges in health care is the routing and scheduling problem to meet people’s needs. Of course, the objective is to considerably minimize costs while respecting priorities according to cases that will face. Through this article, we propose a new technique for home healthcare routing and scheduling problem purely based on an artificial intelligence technique to optimize the offered services within a distributed environment. The automatic learning and search method seem to be interesting to optimize the allocation of visits to beneficiaries. The proposed approach has several advantages in terms of especially cost, efforts, and gaining time. A comparative study was carried out to evaluate the effectiveness of the planned technique compared to previous work. url: https://doi.org/10.1007/s13369-020-04828-5 doi: 10.1007/s13369-020-04828-5 id: cord-350529-yqtu059x author: Evans, Samantha title: Implementation of a clinical pathway for the surgical treatment of colorectal cancer during the COVID‐19 pandemic date: 2020-07-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: This report summarises the early experience of implementing elective colorectal cancer surgery during the COVID‐19 pandemic METHODS: A pathway to minimize the risk of including COVID‐19 positive patients for elective surgery was established. Prioritization and additional safety measures were introduced into clinical practice. Minimal‐invasive surgery (MIS) was used where appropriate. RESULTS: Thirty‐eight patients were prioritised, and 23 patients underwent surgery (8 colon, 14 rectal and 1 anal cancer). MIS rate was 78%. There were no major postoperative complications or patients diagnosed with COVID‐19. Histopathological outcomes were similar to normal practice. CONCLUSION: A safe pathway to offer standard high‐quality surgery to colorectal cancer patients during the COVID‐19 pandemic is feasible. url: https://www.ncbi.nlm.nih.gov/pubmed/32654417/ doi: 10.1111/codi.15247 id: cord-327989-6p39cx2e author: Everaert, Bert title: Emerging cardiological issues during the COVID‐19 pandemic date: 2020-05-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Today the modern world is facing an unprecedented health crisis. The COVID‐19 pandemic is putting extensive strain on health care systems, hospitals and medical workers worldwide. Epidemiological data are emerging that COVID‐19 patients with cardiac risk factors or pre‐existing cardiac conditions are at increased risk for complications and mortality from COVID‐19. As we just begin to understand the pathophysiology underlying the disease, the involvement of the heart, whether through direct myocardial infection and damage or due to cardiac complications, is already evident. url: https://doi.org/10.1111/eci.13270 doi: 10.1111/eci.13270 id: cord-298056-svwtfshi author: Fabio, Ciceri title: Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy date: 2020-06-12 words: 3319.0 sentences: 169.0 pages: flesch: 46.0 cache: ./cache/cord-298056-svwtfshi.txt txt: ./txt/cord-298056-svwtfshi.txt summary: Multivariable analysis showed older age, coronary artery disease, cancer, low lymphocyte count and high RALE score as factors independently associated with an increased risk of mortality. CONCLUSION: In a large cohort of COVID-19 patients of European origin, main risk factors for mortality were older age, comorbidities, low lymphocyte count and high RALE. 14 In this report we describe the demographical, clinical, radiological and laboratory characteristics, as well as the clinical outcomes and the risk factors for mortality, of the first 500 patients with COVID-19 admitted to San Raffaele Scientific Institute, a tertiary care academic hospital in Milan, Italy. With a clinical observation longer than one months from the last patient admitted, w e were able to identify early predictors of mortality related to patient characteristics, radiological and laboratory findings at hospital admission for COVID-19. abstract: BACKGROUND: National health-system hospitals of Lombardy faced a heavy burden of admissions for acute respiratory distress syndromes associated with coronavirus disease (COVID-19). Data on patients of European origin affected by COVID-19 are limited. METHODS: All consecutive patients aged ≥18 years, coming from North-East of Milan's province and admitted at San Raffaele Hospital with COVID-19, between February 25th and March 24th, were reported, all patients were followed for at least one month. Clinical and radiological features at admission and predictors of clinical outcomes were evaluated. RESULTS: Of the 500 patients admitted to the Emergency Unit, 410 patients were hospitalized and analyzed: median age was 65 (IQR 56–75) years, and the majority of patients were males (72.9%). Median (IQR) days from COVID-19 symptoms onset was 8 (5–11) days. At hospital admission, fever (≥ 37.5 °C) was present in 67.5% of patients. Median oxygen saturation (SpO2) was 93% (range 60–99), with median PaO(2)/FiO(2) ratio, 267 (IQR 184–314). Median Radiographic Assessment of Lung Edema (RALE) score was 9 (IQR 4–16). More than half of the patients (56.3%) had comorbidities, with hypertension, coronary heart disease, diabetes and chronic kidney failure being the most common. The probability of overall survival at day 28 was 66%. Multivariable analysis showed older age, coronary artery disease, cancer, low lymphocyte count and high RALE score as factors independently associated with an increased risk of mortality. CONCLUSION: In a large cohort of COVID-19 patients of European origin, main risk factors for mortality were older age, comorbidities, low lymphocyte count and high RALE. url: https://www.sciencedirect.com/science/article/pii/S1521661620304563?v=s5 doi: 10.1016/j.clim.2020.108509 id: cord-298516-0eda4mzs author: Fadlallah, Ali title: LASIK procedures during COVID-19 date: 2020-08-05 words: 586.0 sentences: 44.0 pages: flesch: 56.0 cache: ./cache/cord-298516-0eda4mzs.txt txt: ./txt/cord-298516-0eda4mzs.txt summary: This prospective study was performed in May 2020 following Dubai Health Care City Authority HSE protocol. 3 The preoperative phase started by taking the temperature of the patients, looking for symptoms such as cough or dyspnea, before they entered the center and by doing an intensive medical interview concerning any suspicious exposures or travels. Perioperatively, the procedure was performed in a sterilized environment; staff wore an N95 mask, sterile gloves, and a disposable gown, and patients wore a surgical mask. As for the staff of 7, no one tested COVID polymerase chain reaction positive before or after this study, and no one developed any of the aforementioned symptoms. In conclusions, after following an HSE plan adapted to the American Academy of Ophthalmology, the American College of Surgeons, and U.S. Centers for Disease Control and Prevention recommendations and guidelines, it might be safe to do short outpatient elective procedures requiring topical anesthesia if all personal protective equipment are available. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32818345/ doi: 10.1097/j.jcrs.0000000000000338 id: cord-311957-3rmm1hfb author: Faes, C. title: Time between Symptom Onset, Hospitalisation and Recovery or Death: a Statistical Analysis of Different Time-Delay Distributions in Belgian COVID-19 Patients date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background There are different patterns in the COVID-19 outbreak in the general population and amongst nursing home patients. Different age-groups are also impacted differently. However, it remains unclear whether the time from symptom onset to diagnosis and hospitalization or the length of stay in the hospital is different for different age groups, gender, residence place or whether it is time dependent. Methods Sciensano, the Belgian Scientific Institute of Public Health, collected information on hospitalized patients with COVID-19 hospital admissions from 114 participating hospitals in Belgium. Between March 14, 2020 and June 12, 2020, a total of 14,618 COVID-19 patients were registered. The time of symptom onset, time of COVID-19 diagnosis, time of hospitalization, time of recovery or death, and length of stay in intensive care are recorded. The distributions of these different event times for different age groups are estimated accounting for interval censoring and right truncation in the observed data. Results The truncated and interval-censored Weibull regression model is the best model for the time between symptom onset and diagnosis/hospitalization best, whereas the length of stay in hospital is best described by a truncated and interval-censored lognormal regression model. Conclusions The time between symptom onset and hospitalization and between symptom onset and diagnosis are very similar, with median length between symptom onset and hospitalization ranging between 3 and 10.4 days, depending on the age of the patient and whether or not the patient lives in a nursing home. Patients coming from a nursing home facility have a slightly prolonged time between symptom onset and hospitalization (i.e., 2 days). The longest delay time is observed in the age group 20-60 years old. The time from symptom onset to diagnosis follows the same trend, but on average is one day longer as compared to the time to hospitalization. The median length of stay in hospital varies between 3 and 10.4 days, with the length of stay increasing with age. However, a difference is observed between patients that recover and patients that die. While the hospital length of stay for patients that recover increases with age, we observe the longest time between hospitalization and death in the age group 20-60. And, while the hospital length of stay for patients that recover is shorter for patients living in a nursing home, the time from hospitalization to death is longer for these patients. But, over the course of the first wave, the length of stay has decreased, with a decrease in median length of stay of around 2 days. url: https://doi.org/10.1101/2020.07.18.20156307 doi: 10.1101/2020.07.18.20156307 id: cord-325963-d0hvukbu author: Faes, Christel title: Time between Symptom Onset, Hospitalisation and Recovery or Death: Statistical Analysis of Belgian COVID-19 Patients date: 2020-10-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There are different patterns in the COVID-19 outbreak in the general population and amongst nursing home patients. We investigate the time from symptom onset to diagnosis and hospitalization or the length of stay (LoS) in the hospital, and whether there are differences in the population. Sciensano collected information on 14,618 hospitalized patients with COVID-19 admissions from 114 Belgian hospitals between 14 March and 12 June 2020. The distributions of different event times for different patient groups are estimated accounting for interval censoring and right truncation of the time intervals. The time between symptom onset and hospitalization or diagnosis are similar, with median length between symptom onset and hospitalization ranging between 3 and 10.4 days, depending on the age of the patient (longest delay in age group 20–60 years) and whether or not the patient lives in a nursing home (additional 2 days for patients from nursing home). The median LoS in hospital varies between 3 and 10.4 days, with the LoS increasing with age. The hospital LoS for patients that recover is shorter for patients living in a nursing home, but the time to death is longer for these patients. Over the course of the first wave, the LoS has decreased. url: https://doi.org/10.3390/ijerph17207560 doi: 10.3390/ijerph17207560 id: cord-316095-jzyb4jn5 author: Falahchai, Mehran title: Dental care management during the COVID‐19 outbreak date: 2020-09-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: AIM: The level of preparedness of the healthcare system plays an important role in management of coronavirus disease 2019 (COVID‐19). This study attempted to devise a comprehensive protocol regarding dental care during the COVID‐19 outbreak. METHODS AND RESULT: Embase, PubMed, and Google Scholar were searched until March 2020 for relevant papers. Sixteen English papers were enrolled to answer questions about procedures that are allowed to perform during the COVID‐19 outbreak, patients who are in priority to receive dental care services, the conditions and necessities for patient admission, waiting room and operatory room, and personal protective equipment (PPE) that is necessary for dental clinicians and the office staff. CONCLUSION: Dental treatment should be limited to patients with urgent or emergency situation. By screening questionnaires for COVID‐19, patients are divided into three groups of (a) apparently healthy, (b) suspected for COVID‐19, and (c) confirmed for COVID‐19. Separate waiting and operating rooms should be assigned to each group of patients to minimize the risk of disease transmission. All groups should be treated with the same protective measures with regard to PPE for the dental clinicians and staff. url: https://doi.org/10.1111/scd.12523 doi: 10.1111/scd.12523 id: cord-274481-k1dp1ilv author: Falavigna, Maicon title: Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology date: 2020 words: 6973.0 sentences: 447.0 pages: flesch: 44.0 cache: ./cache/cord-274481-k1dp1ilv.txt txt: ./txt/cord-274481-k1dp1ilv.txt summary: Summary of the evidence: the systematic review identified three comparative clinical trials with available data on the effects of hydroxychloroquine (HCQ) in COVID-19 patients: two open randomized clinical trials (29, 30) in a patient population with mild to moderate disease, and one cohort study. Recommendation 2 -we suggest against the routine use the hydroxychloroquine or chloroquine plus azithromycin combination for treatment of COVID-19 patients (weak recommendation; Level of Evidence very low). Recommendation 4 -We suggest the use of empirical oseltamivir treatment in patients with Severe Acute Respiratory Syndrome (SARS) or flu-like syndrome with risk factors for complications when a diagnosis of influenza cannot be ruled out (weak recommendation; Level of Evidence very low). Summary of the evidence -two randomized clinical trials assessed the use of lopinavir/ritonavir in COVID-19 patients. abstract: INTRODUCTION: Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil. METHODS: A group of 27 experts and methodologists integrated a task-force formed by professionals from the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB), the Brazilian Society of Infectious Diseases (Sociedad Brasileira de Infectologia - SBI) and the Brazilian Society of Pulmonology and Tisiology (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT). Rapid systematic reviews, updated on April 28, 2020, were conducted. The assessment of the quality of evidence and the development of recommendations followed the GRADE system. The recommendations were written on May 5, 8, and 13, 2020. RESULTS: Eleven recommendations were issued based on low or very-low level evidence. We do not recommend the routine use of hydroxychloroquine, chloroquine, azithromycin, lopinavir/ritonavir, corticosteroids, or tocilizumab for the treatment of COVID-19. Prophylactic heparin should be used in hospitalized patients, however, no anticoagulation should be provided for patients without a specific clinical indication. Antibiotics and oseltamivir should only be considered for patients with suspected bacterial or influenza coinfection, respectively. CONCLUSION: So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. The recommendations herein provided will be revised continuously aiming to capture newly generated evidence. url: https://www.ncbi.nlm.nih.gov/pubmed/32667444/ doi: 10.5935/0103-507x.20200039 id: cord-330136-o8df8szx author: Fan, Hua title: Cardiac injuries in patients with coronavirus disease 2019: Not to be ignored date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Objective To describe the clinical features of coronavirus disease 2019 (COVID-19). Methods We recruited 73 patients with COVID-19 [49 men and 24 women; average age: 58.36 years (SD: 14.31)] admitted to the intensive care unit of Wuhan Jinyintan Hospital from December 30, 2019 to February 16, 2020. Demographics, underlying diseases, and laboratory test results on admission were collected and analyzed. Data were compared between survivors and non-survivors. Results The non-survivors were older (65.46 [SD 9.74] vs 46.23 [12.01]) and were more likely to have chronic medical illnesses. Non-survivors tend to develop more severe lymphopenia, with higher C-reactive protein, interleukin-6, D-dimer, and hs-Troponin I(hs-TnI) levels. Patients with elevated hs-TnI levels on admission had shorter duration from symptom onset to death. Increased hs-TnI level was related to dismal prognosis. Death risk increased by 20.8% when the hs-TnI level increased by one unit. After adjusting for inflammatory or coagulation index, the independent predictive relationship between hs-TnI and death disappeared. Conclusions Cardiac injury may occur at the early stage of COVID-19, which is associated with high mortality. Inflammatory factor cascade and coagulation abnormality may be the potential mechanisms of COVID-19 combined with cardiac injury. url: https://doi.org/10.1016/j.ijid.2020.05.024 doi: 10.1016/j.ijid.2020.05.024 id: cord-262518-a2ql8hib author: Fan, Peijin Esther Monica title: Needs and concerns of patients in isolation care units - learnings from COVID-19: A reflection date: 2020-05-26 words: 1918.0 sentences: 101.0 pages: flesch: 60.0 cache: ./cache/cord-262518-a2ql8hib.txt txt: ./txt/cord-262518-a2ql8hib.txt summary: Our hospital''s Senior Patient Experience Managers contact all patients admitted to the isolation wards on a daily basis to provide some form of support. Throughout hospitalization in the isolation wards, patients are not allowed to have visitors, and the only contact they have with their family members is via mobile devices. As part of efforts to mitigate against the adverse effects of isolation, our hospital''s Senior Patient Experience Managers contact all patients admitted to the isolation wards on a daily basis. This paper aims to illustrate patients'' and next-of-kins'' needs and concerns during isolation; and to recommend key process improvement that could better support patients and their loved ones during this challenging time of the COVID-19 pandemic. We would like thank the Nursing Division at Singapore General Hospitals as well as all healthcare workers at the isolation wards for standing strong in our fight against COVID-19 and for providing our patients with the care that they need. abstract: With strict measures in place to contain the spread of coronavirus disease 2019, many have been isolated as suspected or confirmed cases. Being isolated causes much inconvenience for the patients and family. Patients' and next-of-kins’ needs and concerns during isolation will be shared together with suggestions for key process improvements. Our hospital’s Senior Patient Experience Managers contact all patients admitted to the isolation wards on a daily basis to provide some form of support. Common issues raised were gathered and strategies to help with their needs and concerns were discussed. Being in isolation is a challenging period for both patients and family. Nonetheless, we can implement measures to mitigate against the adverse effects of isolation. Patient education, effective and efficient means of communication, close monitoring for signs of distress and anxiety, and early intervention could help patients cope better with the whole isolation experience. Nursing management may want to consider implementing the measures shared in the article to manage patient’s stress while not compromising on staff safety. url: https://doi.org/10.12998/wjcc.v8.i10.1763 doi: 10.12998/wjcc.v8.i10.1763 id: cord-337297-fkw8780t author: Fan, Siyuan title: Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: The complications of coronavirus disease 2019 (COVID-19) involved multiple organs or systems, especially in critically ill patients. We aim to investigate the neurological complications in critically ill patients with COVID-19. Methods: This retrospective single-center case series analyzed critically ill patients with COVID-19 at the intensive care unit of Tongji Hospital, Wuhan, China from February 5 to April 2, 2020. Demographic data, clinical and laboratory findings, comorbidities and treatments were collected and analyzed. Results: Among 86 patients with confirmed COVID-19, 54 patients (62.8%) were male, and the mean (SD) age was 66.6 (11.1) years. Overall, 65% patients presented with at least one neurological symptom. Twenty patients (23.3%) had symptoms involving the central nervous system, including delirium, cerebrovascular diseases and hypoxic-ischemic brain injury, while 6 patients (7%) had neuromuscular involvement. Seven of 86 patients exhibited new stroke and 6 (7%) cases were ischemic. A significantly higher prevalence of antiphospholipid antibodies was observed in patients with ischemic stroke than in those without stroke (83.3 vs. 26.9%, p < 0.05). Patients with ischemic stroke were more likely to have a higher myoglobulin level, and a lower hemoglobin level. Conclusions: The clinical spectrum of neurological complications in critically ill patients with COVID-19 was broad. Stroke, delirium and neuromuscular diseases are common neurological complications of COVID-19. Physicians should pay close attention to neurological complications in critically ill patients with COVID-19. url: https://doi.org/10.3389/fneur.2020.00806 doi: 10.3389/fneur.2020.00806 id: cord-290267-ke696q8j author: Fang, Huilin title: Impact of comorbidities on clinical prognosis in 1280 patients with different types of COVID-19 date: 2020-10-13 words: 4880.0 sentences: 284.0 pages: flesch: 52.0 cache: ./cache/cord-290267-ke696q8j.txt txt: ./txt/cord-290267-ke696q8j.txt summary: In this study, we included patients with COVID-19, divided them into ordinary, severe, and critical types according to the clinical manifestations at admission, and aimed to assess the impact of comorbidities on prognosis in patients with three different types of COVID-19, and to provide reference for the treatment of these patients. According to the Diagnosis and Treatment Program of Novel Coronavirus Pneumonia (Trial Seventh Edition) issued by the National Health Commission, all patients were divided into ordinary, severe, and critical types based on their clinical manifestations at admission. These results indicated that comorbidities can significantly affect the clinical course (length of hospital stay, time from onset to discharge) of ordinary patients, reduce the cure rate, and increase mortality rate of critical patients. In terms of clinical symptoms, ordinary patients without hypertension, diabetes, and coronary heart disease had a significantly higher proportion of fever compared with patients who had those comorbidities (p<0.05). abstract: The study aimed to compare the clinical characteristics and outcomes of patients with different types (ordinary, severe, and critical) of COVID-19. A total of 1280 patients diagnosed with COVID-19 were retrospectively studied, including 793 ordinary patients, 363 severe patients and 124 critical patients. The impact of comorbidities on prognosis in ordinary, severe, and critical patients were compared and analyzed. The most common comorbidities were hypertension (33.0%), followed by diabetes (14.4%). The length of hospital stay and time from the onset to discharge were significantly longer in ordinary patients with comorbidities compared with those without comorbidities. Critical patients with comorbidities had significantly lower cure rate (19.3% vs 38.9%, p<0.05) and significantly higher mortality rate (53.4% vs 33.3%, p<0.05) compared with those without comorbidities. The time from onset to discharge was significantly longer in ordinary patients with hypertension compared with those without hypertension. The mortality rate of critical patients with diabetes was higher than that of patients without diabetes (71.4% vs 42.7%, p<0.05). Men had a significantly increased risk of death than women (OR=4.395, 95% CI 1.896 to 10.185, p<0.05); patients with diabetes had higher risk of death (OR=3.542, 95% CI 1.167 to 10.750, p<0.05). Comorbidities prolonged treatment time in ordinary patients, increased the mortality rate and reduced the cure rate of critical patients; hypertension and diabetes may be important factors affecting the clinical course and prognosis of ordinary and critical patients, respectively. url: https://www.ncbi.nlm.nih.gov/pubmed/33051358/ doi: 10.1136/jim-2020-001555 id: cord-289169-3u7qgxud author: Fang, Xiaowei title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 date: 2020-04-11 words: 494.0 sentences: 42.0 pages: flesch: 52.0 cache: ./cache/cord-289169-3u7qgxud.txt txt: ./txt/cord-289169-3u7qgxud.txt summary: title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 In the present study, all patients were from a single center, and all swab samples were tested using a unified approach at the Chinese Center for Disease Control to avoid measurement bias. In fact, a similar study analyzing data from 72 patients with COVID-19 was conducted at the First Affiliated Hospital of Zhejiang University, and the conclusions were consistent with the results of the present study (7) . In conclusion, low-dose corticosteroid therapy may not delay viral clearance in patients with COVID-19; however, this still needs to be confirmed by well-designed and large-scale Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome Retrospective study of low-to-moderate dose glucocorticoids on viral clearance in patients with novel coronavirus pneumonia abstract: nan url: https://api.elsevier.com/content/article/pii/S0163445320301687 doi: 10.1016/j.jinf.2020.03.039 id: cord-018834-4ligp4ak author: Farag, Ehab title: The Perioperative Use of Albumin date: 2016-06-23 words: 7554.0 sentences: 379.0 pages: flesch: 43.0 cache: ./cache/cord-018834-4ligp4ak.txt txt: ./txt/cord-018834-4ligp4ak.txt summary: HSA is the most important antioxidant capacity of human plasma, in addition to its ability to protect the body from the harmful effects of heavy metals such as iron and copper and reduce their ability to produce reactive oxygen radicals. Recently, its use has been questioned following a widely publicized meta-analysis in 1998 that reported increased mortality in patients who received albumin solutions; the role of albumin administration in critically ill patients became highly controversial. However, the results of this meta-analysis have been challenged by several metaanalyses, randomized controlled trials that not only proved the safety of HSA but its benefi t especially in patients with sepsis, liver failure, hypoalbuminemia, and burns [ 1 -4 ] . HSA administration favorably infl uences plasma thiol-dependent antioxidant status, as well as levels of protein oxidative damage in patients with sepsis and acute respiratory distress syndrome (ARDS) [ 21 , 22 ] . abstract: Human serum albumin (HSA) is the predominant product of hepatic protein synthesis and one of the more abundant plasma proteins. HSA is a monomeric multidomain macromolecule, representing the main determinant of plasma oncotic pressure and the main modulator of fluid distribution between body compartments. HSA displays an essential role in maintaining the integrity of the vascular barrier. HSA is the most important antioxidant capacity of human plasma, in addition to its ability to protect the body from the harmful effects of heavy metals such as iron and copper and reduce their ability to produce reactive oxygen radicals. HSA is the main depot for nitric oxide (NO) transport in the blood. HSA represents the main carrier for fatty acids, affects pharmacokinetics of many drugs, and provides the metabolic modification of some drugs and displays pseudo-enzymatic properties. HSA has been widely used successfully for more than 50 years in many settings of perioperative medicine including hypovolemia, shock, burns, surgical blood loss, sepsis, and acute respiratory distress syndrome (ARDS). Recently, the use of HSA has shown a promising neuroprotective effect in patients with subarachnoid hemorrhage. The most recent evidence-based functions and uses of HSA in the perioperative period are reviewed in this chapter. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123816/ doi: 10.1007/978-3-319-39141-0_9 id: cord-347121-5drl3xas author: Farah, I. title: A global omics data sharing and analytics marketplace: Case study of a rapid data COVID-19 pandemic response platform. date: 2020-09-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Under public health emergencies, particularly an early epidemic, it is fundamental that genetic and other healthcare data is shared across borders in both a timely and accurate manner before the outbreak of a global pandemic. However, although the COVID-19 pandemic has created a tidal wave of data, most patient data is siloed, not easily accessible, and due to low sample size, largely not actionable. Based on the precision medicine platform Shivom, a novel and secure data sharing and data analytics marketplace, we developed a versatile pandemic preparedness platform that allows healthcare professionals to rapidly share and analyze genetic data. The platform solves several problems of the global medical and research community, such as siloed data, cross-border data sharing, lack of state-of-the-art analytic tools, GDPR-compliance, and ease-of-use. The platform serves as a central marketplace of 'discoverability'. The platform combines patient genomic & omics data sets, a marketplace for AI & bioinformatics algorithms, new diagnostic tools, and data-sharing capabilities to advance virus epidemiology and biomarker discovery. The bioinformatics marketplace contains some preinstalled COVID-19 pipelines to analyze virus- and host genomes without the need for bioinformatics expertise. The platform will be the quickest way to rapidly gain insight into the association between virus-host interactions and COVID-19 in various populations which can have a significant impact on managing the current pandemic and potential future disease outbreaks. url: https://doi.org/10.1101/2020.09.28.20203257 doi: 10.1101/2020.09.28.20203257 id: cord-029770-72ncfyc5 author: Farasat, Sadaf title: Sleep and Delirium in Older Adults date: 2020-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: Poor sleep and delirium are common in older patients but recognition and management are challenging, particularly in the intensive care unit (ICU) setting. The purpose of this review is to highlight current research on these conditions, their inter-relationship, modes of measurement, and current approaches to management. RECENT FINDINGS: Sleep deprivation and delirium are closely linked, with shared clinical characteristics, risk factors, and neurochemical abnormalities. Acetylcholine and dopamine are important neurochemicals in the regulation of sleep and wakefulness and their dysregulation has been implicated in development of delirium. In the hospital setting, poor sleep and delirium are associated with adverse outcomes; non-pharmacological interventions are recommended, but tend to be resource intensive and hindered by a lack of reliable sleep measurement tools. Delirium is easier to identify, with validated tools available in both ICU and non-ICU settings; however, an optimal treatment approach remains unclear. Antipsychotics are used widely to prevent and treat delirium, although the efficacy data are equivocal. Bundled non-pharmacologic approaches represent a promising framework for prevention and management. SUMMARY: Poor sleep and delirium are common problems in older patients. While these phenomena appear linked, a causal relationship is not clearly established. At present, there are no established sleep-focused guidelines for preventing or treating delirium. Novel interventions are needed that address poor sleep and delirium, particularly in older adults. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382993/ doi: 10.1007/s40675-020-00174-y id: cord-281003-7pdhxdzc author: Farmakis, Dimitrios title: COVID‐19 and thalassaemia: A position statement of the Thalassaemia International Federation date: 2020-07-13 words: 2829.0 sentences: 159.0 pages: flesch: 44.0 cache: ./cache/cord-281003-7pdhxdzc.txt txt: ./txt/cord-281003-7pdhxdzc.txt summary: METHODS: The present statement summarizes the key challenges concerning the management of haemoglobinopathies, with particular focus on patients with either transfusion‐dependent or non‐transfusion‐dependent thalassaemia, identifies the gaps in knowledge and suggests measures and strategies to deal with the pandemic, based on available evidence and expert opinions. The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected millions across the world, having caused hundreds of thousands deaths. However, disease-related complications may affect multiple organs including the heart, liver, endocrine glands, lungs and the immune system, thus rendering this patient population at an increased risk to develop serious complications during COVID-19. 2, 3, 11 This is especially so in patients who receive suboptimal management and lack access to modern therapy and Thalassaemia patients do not have the same risk of pulmonary infections with sickle cell disease patients but, they may have multiple organ complications, often due to iron overload, including cardiac and hepatic, diabetes mellitus and endocrine disease. abstract: OBJECTIVES: Many patients with haemoglobinopathies, including thalassaemia and sickle cell disease, are at increased risk of developing severe complications from the coronavirus disease 2019 (COVID‐19). Although epidemiologic evidence concerning the novel coronavirus (SARS‐CoV‐2) infection in these patients is currently lacking, the COVID‐19 pandemic represents a significant challenge for haemoglobinopathy patients, their families and their attending physicians. METHODS: The present statement summarizes the key challenges concerning the management of haemoglobinopathies, with particular focus on patients with either transfusion‐dependent or non‐transfusion‐dependent thalassaemia, identifies the gaps in knowledge and suggests measures and strategies to deal with the pandemic, based on available evidence and expert opinions. Key areas covered include patients’ risk level, adaptation of haemoglobinopathy care, safety of blood transfusions, blood supply challenges, and lifestyle and nutritional considerations. CONCLUSIONS: The proposed measures and strategies may be useful as a blueprint for other disorders which require regular hospital visits, as well as for the timely adaptation of patient care during similar future pandemics. url: https://www.ncbi.nlm.nih.gov/pubmed/32573838/ doi: 10.1111/ejh.13476 id: cord-353824-0oyvia6d author: Farooque, Umar title: Coronavirus Disease 2019-Related Acute Ischemic Stroke: A Case Report date: 2020-09-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19) is an active worldwide pandemic with diverse presentations and complications. Most patients present with constitutional and respiratory symptoms. Acute ischemic stroke remains a medical emergency even during the COVID-19 pandemic. Here we present a case of a patient with COVID-19 who presented with acute ischemic stroke in the absence of common risk factors for cerebrovascular accidents. A 70-year-old male patient, with no prior comorbidities, presented to the emergency department (ED) with fever, cough, and shortness of breath for four days, and altered level of consciousness and right-sided weakness with the sensory loss for one day. On examination, the patient had a score of 8/15 on the Glasgow coma scale (GCS). There was a right-sided sensory loss and weakness in both upper and lower limbs with a positive Babinski's sign. The pulmonary examination was remarkable for bilateral crepitation. On blood workup, there was leukocytosis and raised c-reactive protein (CRP). D-dimer, ferritin, thyroid-stimulating hormone (TSH), vitamin B12, and hypercoagulability workup were normal. Transthoracic echocardiography was also normal. COVID-19 polymerase chain reaction (PCR) detected the virus. Chest x-ray showed infiltrations in the left middle and both lower zones of the lungs in the peripheral distribution. Computed tomography (CT) scan of the chest showed peripheral and mid to basal predominant multilobar ground-glass opacities. CT scan of the head showed a large hypodense area, with a loss of gray and white matter differentiation, in the left middle cerebral artery territory. Magnetic resonance imaging (MRI) of the head showed abnormal signal intensity area in the left parietal region. It appeared isointense on T1 image and hyperintense on T2 image. It also showed diffusion restriction on the diffusion-weighted 1 (DW1) image with corresponding low signals on the apparent diffusion coefficient (ADC) map. These findings were consistent with left middle cerebral artery territory infarct due to COVID-19. The patient was intubated in the ED. He was deemed unfit for thrombolysis and started on aspirin, anti-coagulation, and other supportive measures. Patients with COVID-19 should be evaluated early for neurological signs. Timely workup and interventions should be performed in any patient suspected of having a stroke to reduce morbidity and mortality. url: https://doi.org/10.7759/cureus.10310 doi: 10.7759/cureus.10310 id: cord-007567-vst954ef author: Farquharson, Carolyn title: Responding to the severe acute respiratory syndrome (SARS) outbreak: Lessons learned in a Toronto emergency department() date: 2003-06-04 words: 4228.0 sentences: 234.0 pages: flesch: 57.0 cache: ./cache/cord-007567-vst954ef.txt txt: ./txt/cord-007567-vst954ef.txt summary: 3 Epidemiologic evidence indicates that transmission of the illness occurs with close person-toperson contact (to household members, health care workers, or nearby patients who were not protected by contact or respiratory isolation precautions) and through droplet secretions. In an effort to deal with the transmission and onset of illness within health care and community settings, the province of Ontario designated a Provincial Operations Centre (POC), which was responsible for issuing directives to hospitals about patient care and infection control practices. Some had normal chest radiography with no infiltrates demonstrated (yet) but had symptoms of fever, headache, myalgia, and malaise, and 1 of 3 distinct exposures: they had either traveled to Vietnam, China, Hong Kong, Singapore, or Taiwan; they had been exposed to a person with SARS; or they had been a health care worker, patient, or visitor in a hospital in the GTA where there had been recorded cases of SARS transmission. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119307/ doi: 10.1067/men.2003.109 id: cord-337926-6ddvqowr author: Farrell, Sarah title: Recommendations for the Care of Pediatric Orthopaedic Patients During the COVID Pandemic date: 2020-04-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID pandemic has necessitated modifications to pediatric orthopaedic practice to protect patients, families, and healthcare workers and to minimize viral transmission. It is critical to balance the benefits of alterations to current practice to reduce the chances of COVID infection, with the potential long-term impact on patients. Early experiences of the pandemic from orthopaedic surgeons in China, Singapore, and Italy have provided the opportunity to take proactive and preventive measures to protect all involved in pediatric orthopaedic care. These guidelines, based on expert opinion and best available evidence, provide a framework for the management of pediatric orthopaedic patients during the COVID pandemic. General principles include limiting procedures to urgent cases such as traumatic injuries and deferring outpatient visits during the acute phase of the pandemic. Nonsurgical methods should be considered where possible. For patients with developmental or chronic orthopaedic conditions, it may be possible to delay treatment for 2 to 4 months without substantial detrimental long-term impact. url: https://www.ncbi.nlm.nih.gov/pubmed/32301817/ doi: 10.5435/jaaos-d-20-00391 id: cord-354619-pftjhtpo author: Farronato, Marco title: A Call for Action to Safely Deliver Oral Health Care during and Post COVID-19 Pandemic date: 2020-09-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started just a couple of months ago and it grew rapidly causing several deaths and morbidities. The mechanism behind the transmission of the virus is still not completely understood despite a multitude of new specific manuscripts being published daily. This article highlights the oral cavity as a possible viral transmission route into the body via the Angiotensin converting enzyme 2 receptor. It also provides guidelines for routine protective measures in the dental office while delivering oral health care. url: https://doi.org/10.3390/ijerph17186704 doi: 10.3390/ijerph17186704 id: cord-268155-b8lqo52f author: Farrugia, Albert title: Plasma from donors convalescent from SARS-CoV-2 infection – A matter of priorities date: 2020-06-12 words: 443.0 sentences: 37.0 pages: flesch: 45.0 cache: ./cache/cord-268155-b8lqo52f.txt txt: ./txt/cord-268155-b8lqo52f.txt summary: title: Plasma from donors convalescent from SARS-CoV-2 infection – A matter of priorities In the interim, donor panels for hyperimmune Ig production may be constructed and an optimal path for the provision of this medicine may be developed, hopefully with harmonisation between the major regulatory agencies. Convalescent plasma harvested from voluntary donors in state blood services is at risk of being deflected from therapeutic use through preferential patient allocation to clinical trials for other Covid-19 therapies funded by large pharmaceutical companies. Given the continued body of evidence and public effort in the collection and use of convalescent plasma, it is to be hoped that this treatment will be considered as a first line modality and will not be obstructed by commercial considerations. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Effectiveness of convalescent plasma therapy in severe COVID-19 patients Donor centers for convalescent plasma abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1246782020300719?v=s5 doi: 10.1016/j.tracli.2020.05.002 id: cord-335382-fk4um9nw author: Farver, Carol F. title: Molecular Basis of Pulmonary Disease date: 2012-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Pulmonary pathology includes a large spectrum of both neoplastic and non-neoplastic diseases that affect the lung. Many of these are a result of the unusual relationship of the lung with the outside world. Every breath that a human takes brings the outside world into the body in the form of infectious agents, organic and inorganic particles, and noxious agents of all types. Although the lung has many defense mechanisms to protect itself from these insults, these are not infallible; therefore, lung pathology arises. Damage to the lung is particularly important given the role of the lung in the survival of the organism. Any impairment of lung function has widespread effects throughout the body, since all organs depend on the lungs for the oxygen they need. Pulmonary pathology catalogs the changes in the lung tissues and the mechanisms through which these occur. This chapter presents a review of lung pathology and the current state of knowledge about the pathogenesis of each disease. It suggests that a clear understanding of both morphology and mechanism is required for the development of new therapies and preventive measures. url: https://api.elsevier.com/content/article/pii/B9780123744197000184 doi: 10.1016/b978-0-12-374419-7.00018-4 id: cord-013558-0sa63lp3 author: Farwana, Reem title: Watch this space: a systematic review of the use of video-based media as a patient education tool in ophthalmology date: 2020-03-09 words: 2531.0 sentences: 139.0 pages: flesch: 46.0 cache: ./cache/cord-013558-0sa63lp3.txt txt: ./txt/cord-013558-0sa63lp3.txt summary: Eligible articles included peer-reviewed studies involving ophthalmology patients, who received a solely video-based educational intervention to assess for improvement in patient knowledge, behaviour and overall health-related outcomes. This systematic review of the existing literature aimed to assess the efficacy of using video-based media for patient education in ophthalmology. Studies were included in this systematic review if they involved the use of video-based media as a sole intervention for patient education in ophthalmology with endpoints focussed on its impact on patient knowledge, health behaviour or overall clinical outcome. We aimed to study the extent of use of video-based media in influencing patient knowledge, health behaviour and overall clinical outcome. Due to the low number of the studies and heterogeneity of the interventions used and outcomes reported, it is challenging to reach any firm conclusions on the validity of the use of video-based media as a patient education tool in ophthalmology. abstract: Effective clinician-patient communication is particularly important in ophthalmology where long-term adherence to treatment is often required. However, in the context of increasingly pressurised clinics, there is a tendency to resort to written information leaflets not suited to patients with visual impairment, non-English speakers or those with low levels of literacy. Video-based media could be harnessed to enhance clinician-patient communication. This systematic review aimed to assess the efficacy of using video-based media for patient education in ophthalmology. A pre-defined search strategy was used by two independent researchers to systematically review the PubMed, MEDLINE, EMBASE and PsycINFO databases. Eligible articles included peer-reviewed studies involving ophthalmology patients, who received a solely video-based educational intervention to assess for improvement in patient knowledge, behaviour and overall health-related outcomes. The search yielded 481 studies of which 31 passed initial screening. Following full-text analysis, 12 studies met the inclusion criteria, of which seven studies (58.3%) were randomised controlled trials. The majority of studies (58.3%) reported outcomes on patient comprehension with 5/7 (71%) showing statistically significant improvement after video intervention. Four studies (33.3%) reported on patient performance in a task (e.g. drop application method) or overall health-related outcome with 2/4 (50%) showing statistically significant improvement after intervention. Though more evidence is needed, the use of video-based media appears to be effective in improving patient understanding and in certain cases may ameliorate overall outcome. There is a paucity of well-designed studies and future research is required to fully examine the role of video-based media in patient education. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608108/ doi: 10.1038/s41433-020-0798-z id: cord-310084-taaz6mhs author: Fatehi, Poya title: Acute Ischemic and Hemorrhagic Stroke and COVID-19: Case Series date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus COVID-19 pandemic is the defining global health crisis of our time and the greatest challenge we have faced since the World Wars; it can attack several systems in the body and has high complications and mortality. COVID-19 can cause venous and arterial thromboembolism due to immobility, high inflammation, extensive intravascular blood coagulation, and hypoxia. In this study, we report 5 cases of adults with COVID-19, hospitalized in Tohid Hospital, Sanandaj, Iran. Three patients were male and two were female. The youngest patient was 20 years old and the oldest was 55 years old. All patients had at least one family member with coronavirus. Fever, chills, muscular pain, cough, and tachypnea were present in all patients. Red blood cell (RBC) was observed in all patients at a low level. Computed tomography (CT) scans of all patients showed abnormal findings in different areas of the brain. These cases indicate that COVID-19 may damage blood vessels in the brain and lead to stroke. url: https://doi.org/10.1007/s42399-020-00559-8 doi: 10.1007/s42399-020-00559-8 id: cord-312609-gv1khfmo author: Fatima, Nida title: Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Corona virus disease 2019 (COVID-19) pandemic has become a globally challenging issue after its emergence in December 2019 from Wuhan, China. Despite its common presentation as respiratory distress, patients with COVID-19 have also shown neurological manifestation especially stroke. Therefore, the authors sought to determine the etiology, underlying risk factors, and outcomes among patients with COVID-19 presenting with stroke. We conducted a systematic review of the electronic database (PubMed, Google Scholar, Scopus, Medline, EMBASE, and Cochrane library) using different MeSH terms from November 2019 to June 2020. A total of 39 patients with stroke from 6 studies were included. The mean age of our included patients was 61.4 ± 14.2 years. Majority of the patients (n = 36, 92.3%) with COVID-19 had ischemic stroke, 5.1% (n = 2) had hemorrhagic stroke, and 2.6% (n = 1) had cerebral venous thrombosis at the time of initial clinical presentation. Almost all of the patients presented had underlying risk factors predisposing to stroke which included diabetes mellitus, hyperlipidemia, hypertension, and previous history of cerebrovascular disease. 51.2% (n = 20) of the included patients infected with COVID-19 with stroke died, while remaining patients were either discharged home or transferred to a rehabilitation unit. Exploring the neurological manifestation in terms of stroke among patients with COVID-19 is a step towards better understanding of the virus, preventing further spread, and treating the patients affected by this pandemic. url: https://doi.org/10.1007/s10072-020-04637-6 doi: 10.1007/s10072-020-04637-6 id: cord-262626-yk4e737w author: Favaloro, Emmanuel J. title: Recommendations for Minimal Laboratory Testing Panels in Patients with COVID-19: Potential for Prognostic Monitoring date: 2020-04-12 words: 1168.0 sentences: 67.0 pages: flesch: 44.0 cache: ./cache/cord-262626-yk4e737w.txt txt: ./txt/cord-262626-yk4e737w.txt summary: 1 Although this is recognized as a viral respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathophysiology of the disease is far wider than respiratory, including long-term risk for adverse cardiovascular disease, thromboembolic disorders, and multiple organ failure (MOF). 4, 5 Based on our understanding of the emerging literature, we aim to provide in this short commentary a simple list (►Table 1) of laboratory tests, as may be recommended for patients with COVID-19 and to potentially assist in prognostic monitoring of such patients. D-dimer is associated with severity of coronavirus disease 2019 (COVID-19): a pooled analysis Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32279286/ doi: 10.1055/s-0040-1709498 id: cord-329989-176cvimy author: Federico, Antonio title: Scientific publishing in the COVID-19 era: successes and pitfalls date: 2020-07-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s10072-020-04550-y doi: 10.1007/s10072-020-04550-y id: cord-288181-9thl46oe author: Fekkar, Arnaud title: Fungal Infection during COVID-19: Does Aspergillus Mean Secondary Invasive Aspergillosis? date: 2020-09-15 words: 1536.0 sentences: 92.0 pages: flesch: 38.0 cache: ./cache/cord-288181-9thl46oe.txt txt: ./txt/cord-288181-9thl46oe.txt summary: The authors report a high incidence of presumed invasive pulmonary aspergillosis (6 of 31; 19.4%) among patients with coronavirus disease (COVID-19) admitted to intensive care. The association between aspergillosis and COPD is well known; in a recent prospective study, 14% of patients with COPD exacerbations had respiratory samples with Aspergillus spp. We thank Fekkar and colleagues for their thoughtful comments on our case series of patients with coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA) (1). Cohort studies in patients with influenza-associated pulmonary aspergillosis (IAPA) in the ICU demonstrated that any indication of Aspergillus through positive culture or galactomannan (GM) detection is highly indicative of invasive aspergillosis (2) . Reports of presumed CAPA cases that survive without antifungal therapy, such as those presented by Fekkar and Alanio, are very informative and suggest that in patients with COVID-19, Aspergillus colonization is more common compared with in patients with influenza (5) . abstract: nan url: https://doi.org/10.1164/rccm.202005-1945le doi: 10.1164/rccm.202005-1945le id: cord-332036-op6s8tr4 author: Feldman, Candace H. title: Widening Disparities Among Patients with Rheumatic Diseases in the COVID‐19 Era: An Urgent Call to Action date: 2020-05-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Recent data from multiple public health departments across the U.S. highlighting the disproportionate burden of COVID‐19 infections in vulnerable populations serve as an urgent call to action. As rheumatologists, we are acutely aware of the higher morbidity and mortality, and for a number of our diseases, the higher incidence and prevalence among racial/ethnic minorities and individuals of lower socioeconomic status (SES). Comorbidities are frequent, timely access to subspecialty care is limited, receipt of high quality care is less common, and care is more often fragmented with frequent, avoidable acute care use. url: https://doi.org/10.1002/art.41306 doi: 10.1002/art.41306 id: cord-301011-xbuqd0j5 author: Felten-Barentsz, Karin M title: Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19 date: 2020-06-18 words: 3952.0 sentences: 259.0 pages: flesch: 39.0 cache: ./cache/cord-301011-xbuqd0j5.txt txt: ./txt/cord-301011-xbuqd0j5.txt summary: In line with international initiatives, this article aims to provide guidance and detailed recommendations for hospital-based physical therapists managing patients hospitalized with COVID-19 through a national approach in the Netherlands. A working group conducted a purposive scan of the literature and drafted initial recommendations based on the knowledge of symptoms in patients with COVID-19, and current practice for physical therapist management for patients hospitalized with lung disease and patients admitted to the intensive care unit (ICU). 12 In line with this international study 12 and the consensus statement of Italian respiratory therapists 13 we aim to provide guidance and detailed recommendations for hospital-based physical therapists managing patients hospitalized with COVID-19 through a national approach in the Netherlands. Physical therapist management for patients hospitalized with COVID-19 comprises elements of respiratory support and active mobilization. Physical therapist management for patients hospitalized with COVID-19 comprises elements of respiratory support and active mobilization. abstract: OBJECTIVE: The COVID-19 pandemic is rapidly evolving and has led to increased numbers of hospitalizations worldwide. Hospitalized patients with COVID-19 experience a variety of symptoms, including fever, muscle pain, tiredness, cough, and difficulty breathing. Elderly people and those with underlying health conditions are considered to be more at risk of developing severe symptoms and have a higher risk of physical deconditioning during their hospital stay. Physical therapists have an important role in supporting hospitalized patients with COVID-19 but also need to be aware of challenges when treating these patients. In line with international initiatives, this article aims to provide guidance and detailed recommendations for hospital-based physical therapists managing patients hospitalized with COVID-19 through a national approach in the Netherlands. METHODS: A pragmatic approach was used. A working group conducted a purposive scan of the literature and drafted initial recommendations based on the knowledge of symptoms in patients with COVID-19, and current practice for physical therapist management for patients hospitalized with lung disease and patients admitted to the intensive care unit (ICU). An expert group of hospital-based physical therapists in the Netherlands provided feedback on the recommendations, which were finalized when consensus was reached among the members of the working group. RESULTS: The recommendations include safety recommendations, treatment recommendations, discharge recommendations, and staffing recommendations. Treatment recommendations address 2 phases of hospitalization: when patients are critically ill and admitted to the ICU, and when patients are severely ill and admitted to the COVID ward. Physical therapist management for patients hospitalized with COVID-19 comprises elements of respiratory support and active mobilization. Respiratory support includes breathing control, thoracic expansion exercises, airway clearance techniques, and respiratory muscle strength training. Recommendations toward active mobilization include bed mobility activities, active range-of-motion exercises, active (−assisted) limb exercises, activities-of-daily-living training, transfer training, cycle ergometer, pre-gait exercises, and ambulation. url: https://www.ncbi.nlm.nih.gov/pubmed/32556323/ doi: 10.1093/ptj/pzaa114 id: cord-355504-zsyvgm9c author: Feng, Feng title: Longitudinal changes of pneumonia complicating novel influenza A (H1N1) by high-resolution computed tomography date: 2015-06-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To assess lung lesions in patients with pneumonia complicating novel influenza A (H1N1) by serial high-resolution computed tomography (HRCT) during the early, progressive and convalescent stages. SAMPLES AND METHODS: Serial HRCT scans in 39 patients with pneumonia complicating novel influenza A (H1N1) were reviewed for predominant patterns of lung abnormalities as well as distribution and extent of involvement. Longitudinal changes were assessed at different time points. RESULTS: In the early stage, the most common HRCT finding was patchy ground-glass opacity (GGO) (n = 4, 54.7%). In the progressive stage, bilaterally distributed GGO mixed with consolidation was the most commonly observed feature (n = 28, 71.8%). The diffuse pattern deteriorated to a peak (n = 17, 43.6%) at this stage. In the convalescent stage, the most common finding was fibrosis (n = 25, 64.1%). Averagely, fibrosis was observed at d 18.5 ± 6.4 after the onset of symptoms. Three patterns of longitudinal changes of the lesions were observed, including: type 1, improvement after deterioration; type 2, concurrent improvement and deterioration followed by improvement; and type 3, gradual improvement. Type 1 was the more common pattern (n = 27, 69.2%). Complete serial HRCT scans from initial and final scan were obtained in 24 patients, and the mean CT score peaked at d 8–14 of the illness. CONCLUSION: HRCT may play a role in detecting and characterizing pulmonary lesions for the cases of pneumonia complicating influenza A. In addition, it may contribute to monitoring longitudinal changes of pneumonia and assessing therapeutic response. url: https://api.elsevier.com/content/article/pii/S2352621115000352 doi: 10.1016/j.jrid.2015.06.001 id: cord-335095-epsi5qq7 author: Feng, Gong title: Clinical Features of COVID-19 Patients in Xiaogan City date: 2020-08-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: On February 6, 2020, Xiaogan City became the second most seriously affected city with coronavirus disease 2019 (COVID-19), outside Wuhan district, Hubei Province, China. The objectives are to study the clinical features of COVID-19 patients and assess the relationship between the severity of COVID-19, age, and C-reactive protein (CRP) levels. The retrospective data of 134 COVID-19 patients hospitalized in 3 hospitals of Xiaogan City, between February 1 and March 1, 2020, was collected. This study documented COVID-19 patients. Clinical data in terms of body temperature, history of travel, and direct contact with COVID-19 patients, and incubation period was collected. Out of the 134 patients, only 5 required intensive care. Moreover, 2 patients succumbed during this period. The median age of patients was 45 (33–56) years. The most common symptoms at the onset of disease were fever (66.4%), cough (33, 6%), and sore throat (14.7%). Amongst the medicines used, antiviral agents (92.3%) followed by the traditional Chinese medicine (89.5%) were most commonly used. In both the crude and adjusted (I to III) models, odds ratio and its 95% confidence interval for both age and CRP levels were > 1. Moreover, the smooth curve fitting graph reflected that the severity of COVID-19 was positively correlated with both age and CRP levels (all P value < 0.05). The signs and symptoms of COVID-19 patients were fairly moderate. The health care professionals treating the COVID-19 patients should be aware of the increased likelihood of progression to severe COVID-19 in elderly patients and those with high CRP levels. url: https://www.ncbi.nlm.nih.gov/pubmed/32864573/ doi: 10.1007/s42399-020-00465-z id: cord-305479-o47mv4uw author: Feng, Xiaobo title: Clinical Characteristics and Short-Term Outcomes of Severe Patients With COVID-19 in Wuhan, China date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: A novel pneumonia (COVID-19) spread rapidly throughout worldwide, in December, 2019. Most of the deaths have occurred in severe and critical cases, but information on prognostic risk factors for severely ill patients is incomplete. Further research is urgently needed to guide clinicians, and we therefore prospectively evaluate the clinical outcomes of 114 severely ill patients with COVID-19 for short-term at the Union Hospital in Wuhan, China. Methods: In this single-centered, prospective, and observational study, we enrolled 114 severely ill patients with confirmed COVID-19 from Jan 23, 2020, to February 22, 2020. Epidemiological, demographic, laboratory, treatment, and outcome data were recorded, and the risk factors for poor outcome were analyzed. Results: Among the 114 enrolled patients with a mean age of 63.96 ± 13.41 years, 94 (82.5%) patients were classified as a good outcome group. Common clinical manifestations included fever, cough, and fatigue. Compared with the good outcome group, 20 (17.5%) patients in the poor outcome group more frequently exhibited lymphopenia, and lower levels of albumin, partial arterial oxygen pressure, higher levels of lactate dehydrogenase, creatine kinase, hypersensitive troponin I, C-reactive protein, ferritin, blood urea nitrogen, and D-dimer, as well as markedly higher levels of IL-6 and IL-10. Absolute numbers of T lymphocytes, CD8 + T cells, decreased in almost all the patients and were markedly lower in the poor outcome group than the good outcome group. We also found that traditional Chinese medicine can significantly improve the patient's condition, which is conducive to the transformation from a severe to mild condition. In addition, univariate and multivariate Cox analyses of potential factors for poor outcome patients indicated that cytokine storms and uncontrolled inflammation responses as well as liver, kidney, and cardiac dysfunction are related to the development of a poor outcome. Conclusion: In summary, we reported this single-centered, prospective, and observational study for short-term outcome in severe patients with COVID-19. We found that cytokine storms and uncontrolled inflammation responses as well as liver, kidney, and cardiac dysfunction may play important roles in the final outcome of severely ill patients with COVID-19. Our study will allow clinicians to benefit and rapidly estimate the likelihood of a short-term poor outcome for severely ill patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32850926/ doi: 10.3389/fmed.2020.00491 id: cord-282430-u5ukqc5z author: Fenton, Mark E. title: An Expanded COVID-19 Telemedicine Intermediate Care Model Using Repurposed Hotel Rooms date: 2020-10-15 words: 2172.0 sentences: 94.0 pages: flesch: 38.0 cache: ./cache/cord-282430-u5ukqc5z.txt txt: ./txt/cord-282430-u5ukqc5z.txt summary: The Pleural Pressure Working Group''s planned RECRUIT (Recruitment Assessed by Electrical Impedance Tomography: Feasibility, Correlation with Clinical Outcomes and Pilot Data on Personalised PEEP Selection) project (https:// www.plugwgroup.org/), which aims to compare the results of different bedside methods to titrate PEEP based on EIT, might provide us with some answers on how to titrate PEEP using EIT data. Bruni and colleagues have built the clinical care model around twice daily assessment of patients by a respiratory physician using remote monitoring (no details of how monitoring is done were included) (1). We really thank Fenton and colleagues for their interest in our article (1) and the pleasing comments regarding our telemedicine-supported hotel accommodation model for patients with coronavirus disease (COVID-19) . Electrical impedance tomography for positive end-expiratory pressure titration in COVID-19-related acute respiratory distress syndrome Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32790480/ doi: 10.1164/rccm.202007-2902le id: cord-009788-bc6sc2rc author: Ferguson, J. K. title: Preventing healthcare‐associated infection: risks, healthcare systems and behaviour date: 2009-09-17 words: 3554.0 sentences: 200.0 pages: flesch: 41.0 cache: ./cache/cord-009788-bc6sc2rc.txt txt: ./txt/cord-009788-bc6sc2rc.txt summary: The Quality in Australian Health Care Study (QAHCS) 1 estimated that 5.5% of hospital admissions were affected by healthcare-associated infection (HAI), with an estimate at that time of 155 000 infections per annum across Australia. 11 MRSA infected or colonized patients admitted to hospital increase the risk of MRSA spread to healthcare staff and their families. 16 Healthcare staff and other patients must be protected from infectious fine particle (<5 mM) aerosols that are capable of transmitting infection at low doses †Active screening and isolation for methicillin-resistant Staphylococcus aureus-colonized patients/staff is not performed at some Australian sites as it is considered to be an ineffective measure. [22] [23] [24] A national initiative commenced in 2008 to improve hand hygiene, focusing on education, provision of alcohol-based hand rub at every bedside, reliable, regular audits of compliance with effective feedback to staff and management, and measurement of patient infection outcomes (healthcare-associated S. abstract: More than 177 000 potentially preventable healthcare‐associated infections (HAIs) occur per annum in Australia with sizable attributable mortality. Organizational systems to protect against HAI in hospitals in Australia are relatively poorly developed. Awareness and practice of infection control by medical and other healthcare staff are often poor. These lapses in practice create significant risk for patients and staff from HAI. Excessive patient exposure to antimicrobials is another key factor in the emergence of antibiotic‐resistant bacteria and Clostridium difficile infection. Physicians must ensure that their interactions with patients are safe from the infection prevention standpoint. The critical preventative practice is hand hygiene in accord with the World Health Organization 5 moments model. Improving the use of antimicrobials, asepsis and immunization also has great importance. Hospitals should measure and feed back HAI rates to clinical teams. Physicians as leaders, role models and educators play an important part in promoting adherence to safe practices by other staff and students. They are also potentially effective system engineers who can embed safer practices in all elements of patient care and promote essential structural and organizational change. Patients and the public in general are becoming increasingly aware of the risk of infection when entering a hospital and expect their carers to adhere to safe practice. Poor infection control practice will be regarded in a negative light by patients and their families, regardless of any other manifest skills of the practitioner. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165553/ doi: 10.1111/j.1445-5994.2009.02004.x id: cord-257839-kfzc4pwq author: Ferguson, Katie title: COVID-19 associated with extensive pulmonary arterial, intracardiac and peripheral arterial thrombosis date: 2020-08-03 words: 2800.0 sentences: 176.0 pages: flesch: 48.0 cache: ./cache/cord-257839-kfzc4pwq.txt txt: ./txt/cord-257839-kfzc4pwq.txt summary: We present this case to highlight the extensive COVID-19-associated thrombotic complications that can occur, even despite periods of high-dose prophylactic and therapeutic anticoagulation. In recent case series, elevated D-dimer levels were reported in 43% 6 of the patients and were associated with disease severity and increased mortality. 5 Findings that shed new light on the possible pathogenesis of a disease or an adverse effect Several case series exist which explore the incidence of venous and arterial thrombosis in patients with COVID-19. 10 The latter includes a study of 10 ICU patients with COVID-19 pneumonia in whom D-dimer levels and viscoelastic measures reduced in response to increased prophylactic dosing. [11] [12] [13] Twitter Nathaniel Quail @DrNatQuail and Kevin G Blyth @kevingblyth Acknowledgements Dr Joe Sarvesvaran''s care and compassion were integral to this patient''s journey to recovery and we would like to acknowledge his support with writing this case report, and for selecting the key images to include. abstract: We describe a patient with COVID-19 who developed simultaneous pulmonary, intracardiac and peripheral arterial thrombosis. A 58-year-old man, without major comorbidity, was admitted with a 14-day history of breathlessness. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection was confirmed by laboratory testing. Initial imaging revealed COVID-19 pneumonia but no pulmonary thromboembolism (PTE) on CT pulmonary angiography (CTPA). The patient subsequently developed respiratory failure and left foot ischaemia associated with a rising D-dimer. Repeat CTPA and lower limb CT angiography revealed simultaneous bilateral PTE, biventricular cardiac thrombi and bilateral lower limb arterial occlusions. This case highlights a broad range of vascular sequalae associated with COVID-19 and the fact that these can occur despite a combination of prophylactic and treatment dose anticoagulation. url: https://www.ncbi.nlm.nih.gov/pubmed/32747597/ doi: 10.1136/bcr-2020-237460 id: cord-004949-icsey27p author: Fernandez-Botran, Rafael title: Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia date: 2014-02-21 words: 4044.0 sentences: 193.0 pages: flesch: 43.0 cache: ./cache/cord-004949-icsey27p.txt txt: ./txt/cord-004949-icsey27p.txt summary: The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Compared to non-severe CAP patients, the severe CAP group showed higher plasma levels of proand anti-inflammatory cytokines but in contrast, lower sputum concentrations of pro-inflammatory cytokines. The objectives of this study were to characterize and contrast the lung and systemic cytokine profiles as well as blood neutrophil responses in patients with severe versus non-severe CAP at the time of hospital admission. In order to compare results of the plasma cytokines and neutrophil functional assays from CAP patients with those of healthy individuals, blood samples were also obtained from a control group (n=12) of healthy adult donors (approved by the University of Louisville′s IRB #191.06). Generally, patients in the severe CAP group showed a pattern with median plasma concentrations of both pro-and anti-inflammatory cytokines that were higher in comparison with the non-severe CAP group and the healthy control group. abstract: The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (PSI ≥ 91 points). Blood and sputum samples were collected upon admission. Compared to non-severe CAP patients, the severe CAP group showed higher plasma levels of pro- and anti-inflammatory cytokines but in contrast, lower sputum concentrations of pro-inflammatory cytokines. Blood neutrophil functional responses were elevated in CAP patients compared to healthy controls. However, neutrophils from severe CAP patients showed reduced respiratory burst activity compared to the non-severe group. Results indicate that patients with severe CAP fail to mount a robust local pro-inflammatory response but exhibit instead a more substantial systemic inflammatory response, suggesting that a key driver of CAP severity may be the ability of the patient to generate an optimal local inflammatory response. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10753-014-9840-2) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087758/ doi: 10.1007/s10753-014-9840-2 id: cord-004147-9bcq3jnm author: Fernando, Shannon M. title: New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study date: 2020-01-13 words: 4162.0 sentences: 213.0 pages: flesch: 43.0 cache: ./cache/cord-004147-9bcq3jnm.txt txt: ./txt/cord-004147-9bcq3jnm.txt summary: title: New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study CONCLUSIONS: While NOAF was not associated with death or requiring discharge to long-term care among critically ill patients, it was associated with increased length of stay in ICU and increased total costs. We primarily sought to evaluate the association between NOAF and outcomes, resource utilization, and costs among critically ill adult patients. However, NOAF was associated with higher hospital mortality among ICU patients with suspected infection (aOR 1.21 [95% CI 1.08-1.37]), sepsis (aOR 1.24 [95% CI 1.10-1.39]), and septic shock (aOR 1.28 [95% CI 1.14-1.44]). Among patients with NOAF, factors associated with increased risk of hospital mortality included increasing age, increased MODS score, history of CHF (as identified in the Data Warehouse), and sustained AF (Additional file 5: Table S5 ). abstract: BACKGROUND: New-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Furthermore, little is known regarding the association between NOAF and resource use or hospital costs. METHODS: Retrospective analysis (2011–2016) of a prospectively collected registry from two Canadian hospitals of consecutive ICU patients aged ≥ 18 years. We excluded patients with a known history of AF prior to hospital admission. Any occurrence of atrial fibrillation (AF) was prospectively recorded by bedside nurses. The primary outcome was hospital mortality, and we used multivariable logistic regression to adjust for confounders. We used a generalized linear model to evaluate contributors to total cost. RESULTS: We included 15,014 patients, and 1541 (10.3%) had NOAF during their ICU admission. While NOAF was not associated with increased odds of hospital death among the entire cohort (adjusted odds ratio [aOR] 1.02 [95% confidence interval [CI] 0.97–1.08]), an interaction was noted between NOAF and sepsis, and the presence of both was associated with higher odds of hospital mortality (aOR 1.28 [95% CI 1.09–1.36]) than either alone. Patients with NOAF had higher total costs (cost ratio [CR] 1.09 [95% CI 1.02–1.20]). Among patients with NOAF, treatment with a rhythm-control strategy was associated with higher costs (CR 1.24 [95% CI 1.07–1.40]). CONCLUSIONS: While NOAF was not associated with death or requiring discharge to long-term care among critically ill patients, it was associated with increased length of stay in ICU and increased total costs. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958729/ doi: 10.1186/s13054-020-2730-0 id: cord-313468-lloh1b0y author: Fernández‐Aranda, Fernando title: COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity—A collaborative international study date: 2020-09-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Confinement during the COVID‐19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explore the general acceptation of the use of telemedicine during confinement. The sample comprised 121 participants (87 ED patients and 34 patients with obesity) recruited from six different centres. Confirmatory Factor Analyses (CFA) tested the rational‐theoretical structure of the CIES. Adequate goodness‐of‐fit was obtained for the confirmatory factor analysis, and Cronbach alpha values ranged from good to excellent. Regarding the effects of confinement, positive and negative impacts of the confinement depends of the eating disorder subtype. Patients with anorexia nervosa (AN) and with obesity endorsed a positive response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology. Furthermore, AN patients expressed the greatest dissatisfaction and accommodation difficulty with remote therapy when compared with the previously provided face‐to‐face therapy. The present study provides empirical evidence on the psychometric robustness of the CIES tool and shows that a negative confinement impact was associated with ED subtype, whereas OSFED patients showed the highest impairment in eating symptomatology and in psychopathology. url: https://doi.org/10.1002/erv.2784 doi: 10.1002/erv.2784 id: cord-293740-4c3yemi3 author: Ferrando, Carlos title: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS date: 2020-07-29 words: 4327.0 sentences: 253.0 pages: flesch: 51.0 cache: ./cache/cord-293740-4c3yemi3.txt txt: ./txt/cord-293740-4c3yemi3.txt summary: METHODS: This is a multicenter, prospective, observational study in consecutive, mechanically ventilated patients with ARDS (as defined by the Berlin criteria) affected with with COVID-19 (confirmed SARS-CoV-2 infection in nasal or pharyngeal swab specimens), admitted to a network of 36 Spanish and Andorran intensive care units (ICUs) between March 12 and June 1, 2020. [temperature, mean arterial pressure (MAP), heart rate], laboratory parameters (blood test, coagulation, biochemical), ventilatory parameters [tidal volume (VT), inspiratory oxygen fraction (FiO 2 ), respiratory rate (RR), PEEP, plateau pressure (Pplat), driving pressure (DP), respiratory system compliance (Crs)], the use of adjunctive therapies [recruitment maneuvers (RM), prone position, neuromuscular blocking agents (NMBA), extracorporeal membrane oxygenation (ECMO)], pharmacological treatments, disease chronology [time from onset of symptoms and from hospital admission to initiation of mechanical ventilation (MV), ventilator-free days (VFDs) during the first 30 days, ICU length of stay (LOS)]. abstract: PURPOSE: The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known. We describe characteristics and outcomes of confirmed ARDS in COVID-19 patients managed with invasive mechanical ventilation (MV). METHODS: This is a multicenter, prospective, observational study in consecutive, mechanically ventilated patients with ARDS (as defined by the Berlin criteria) affected with with COVID-19 (confirmed SARS-CoV-2 infection in nasal or pharyngeal swab specimens), admitted to a network of 36 Spanish and Andorran intensive care units (ICUs) between March 12 and June 1, 2020. We examined the clinical features, ventilatory management, and clinical outcomes of COVID-19 ARDS patients, and compared some results with other relevant studies in non-COVID-19 ARDS patients. RESULTS: A total of 742 patients were analysed with complete 28-day outcome data: 128 (17.1%) with mild, 331 (44.6%) with moderate, and 283 (38.1%) with severe ARDS. At baseline, defined as the first day on invasive MV, median (IQR) values were: tidal volume 6.9 (6.3–7.8) ml/kg predicted body weight, positive end-expiratory pressure 12 (11–14) cmH(2)O. Values of respiratory system compliance 35 (27–45) ml/cmH(2)O, plateau pressure 25 (22–29) cmH(2)O, and driving pressure 12 (10–16) cmH(2)O were similar cto values from non-COVID-19 ARDS observed in other studies. Recruitment maneuvers, prone position and neuromuscular blocking agents were used in 79%, 76% and 72% of patients, respectively. The risk of 28-day mortality was lower in mild ARDS [hazard ratio (RR) 0.56 (95% CI 0.33–0.93), p = 0.026] and moderate ARDS [hazard ratio (RR) 0.69 (95% CI 0.47–0.97), p = 0.035] when compared to severe ARDS. The 28-day mortality was similar to other observational studies in non-COVID-19 ARDS patients. CONCLUSIONS: In this large series, COVID-19 ARDS patients have features similar to other causes of ARDS, compliance with lung-protective ventilation was high, and the risk of 28-day mortality increased with the degree of ARDS severity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-020-06192-2) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32728965/ doi: 10.1007/s00134-020-06192-2 id: cord-325619-qmszgw66 author: Ferrari, Andrea title: Children with cancer in the time of COVID‐19: An 8‐week report from the six pediatric onco‐hematology centers in Lombardia, Italy date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32452123/ doi: 10.1002/pbc.28410 id: cord-252159-6t35bxwv author: Ferraù, F. title: What we have to know about corticosteroids use during Sars-Cov-2 infection date: 2020-08-28 words: 5201.0 sentences: 237.0 pages: flesch: 31.0 cache: ./cache/cord-252159-6t35bxwv.txt txt: ./txt/cord-252159-6t35bxwv.txt summary: PURPOSE: Glucocorticoids (GCs), alone or associated to other drugs, were widely used in the management of patients affected by severe acute respiratory syndrome caused by SARS-CoV-2 infection, during the recent COVID-19 outbreak. RESULTS: GC treatment can cause symptoms of hypercortisolism, especially in patients with individual hypersensibility, or hypoadrenalism after drug withdrawal, due to hypothalamic–pituitary–adrenal (HPA) axis suppression, with consequences in terms of increased morbidity and mortality risk. On the other hand, prolonged steroids treatment can cause symptoms of hypercortisolism, especially in patients with individual hypersensibility, or hypoadrenalism after drug withdrawal, due to hypothalamic-pituitary-adrenal (HPA) axis suppression. This review summarizes the available data on HPA axis impairment in GC-treated Sars-Cov2 patients, focusing on the risk of adrenal insufficiency and on potential drug interactions during concomitant treatments. This review summarizes the available data on HPA axis impairment in GC-treated Sars-Cov2 patients, focusing on the risk of adrenal insufficiency and on potential drug interactions during concomitant treatments. abstract: PURPOSE: Glucocorticoids (GCs), alone or associated to other drugs, were widely used in the management of patients affected by severe acute respiratory syndrome caused by SARS-CoV-2 infection, during the recent COVID-19 outbreak. This review summarizes the available data on HPA axis impairment in GC-treated SARS-CoV-2 patients, focusing on the risk of adrenal insufficiency and on potential drug interactions during concomitant treatments. METHODS: Literature on the impact of GCs therapy on HPA axis and on the consequences of coadministration of GCs and other drugs in SARS-CoV-2 patients has been reviewed. RESULTS: GC treatment can cause symptoms of hypercortisolism, especially in patients with individual hypersensibility, or hypoadrenalism after drug withdrawal, due to hypothalamic–pituitary–adrenal (HPA) axis suppression, with consequences in terms of increased morbidity and mortality risk. On the other hand, in SARS-CoV-2-infected patient’s cortisol secretion could be insufficient also due to critical illness-related corticosteroid insufficiency (CIRCI). In addition, in this clinical context, the co-administration of antiretroviral drugs and corticosteroids may trigger drug–drug interaction and enhance the exposure to the latter ones, metabolized through the CYP450 CYP3A pathway, severely impacting on HPA axis. CONCLUSION: Physicians involved in the management of patients affected by COVID-19 should be aware of the need of an appropriate GC dose tapering, and of potential interaction of GCs with antiviral therapy and drugs used to treat associated co-morbidities. url: https://www.ncbi.nlm.nih.gov/pubmed/32860209/ doi: 10.1007/s40618-020-01384-5 id: cord-301992-oin1m0uq author: Ferreira, Cristine Homsi Jorge title: A guide to physiotherapy in urogynecology for patient care during the COVID-19 pandemic date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION AND AIM: Physiotherapy in urogynecology faces challenges to safely continuing its work, considering the adoption of social distancing measures during the COVID-19 pandemic. Some guidelines have already been published for urogynecology; however, no specific documents have been produced on physiotherapy in urogynecology. This article aimed to offer guidance regarding physiotherapy in urogynecology during the COVID-19 pandemic. METHODS: A group of experts in physiotherapy in women’s health performed a literature search in the Pubmed, PEDro, Web of Science and Embase databases and proposed a clinical guideline for physiotherapy management of urogynecological disorders during the COVID-19 pandemic. This document was reviewed by other physiotherapists and a multidisciplinary panel, which analyzed the suggested topics and reached consensus. The recommendations were grouped according to their similarities and allocated into categories. RESULTS: Four categories of recommendations (ethics and regulation issues, assessment of pelvic floor muscle function and dysfunction, health education and return to in-person care) were proposed. Telephysiotherapy and situations that need in-person care were also discussed. Regionalization is another topic that was considered. CONCLUSION: This study provides some guidance for continuity of the physiotherapist's work in urogynecology during the COVID-19 pandemic, considering the World Health Organization recommendations and the epidemiological public health situation of each region. Telephysiotherapy can also be used to provide continuity of the care in this area during the COVID-19 pandemic, opening new perspectives for physiotherapy in urogynecology. url: https://doi.org/10.1007/s00192-020-04542-8 doi: 10.1007/s00192-020-04542-8 id: cord-330061-q4xi260z author: Ferreira, João Guimarães title: Pneumothorax as a late complication of COVID-19 date: 2020-08-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In late 2019, a novel coronavirus initially related to a cluster of severe pneumonia cases in China was identified. COVID-19 cases have rapidly spread to multiple countries worldwide. We present a typical laboratory confirmed case of COVID-19 pneumonia, that was hospitalized due to hypoxemia but did not require mechanical ventilation. Although initially the patient was evaluated with a favorable outcome, in the third week of the disease, the symptomatology deteriorated due to a massive hypertensive pneumothorax with no known previous risk factor. Since the first cases of COVID-19 have been described, pneumothorax was characterized as a potential, though uncommon, complication. It has been reported that diffuse alveolar injury caused by SARS-CoV-2 can cause alveolar rupture, produce air leakage and interstitial emphysema. Although uncommon, pneumothorax should be listed as a differential diagnosis for COVID-19 patients with sudden respiratory decompensation. As a life-threatening event, it requires prompt recognition and expeditious treatment. url: https://doi.org/10.1590/s1678-9946202062061 doi: 10.1590/s1678-9946202062061 id: cord-009278-98ebmd33 author: Ferreira-Coimbra, João title: Burden of Community-Acquired Pneumonia and Unmet Clinical Needs date: 2020-02-18 words: 5567.0 sentences: 282.0 pages: flesch: 39.0 cache: ./cache/cord-009278-98ebmd33.txt txt: ./txt/cord-009278-98ebmd33.txt summary: Community-acquired pneumonia (CAP) is the leading cause of death among infectious diseases and an important health problem, having considerable implications for healthcare systems worldwide. Recently, Nature Medicine published the first use of phages to treat a multidrug-resistant (MDR) microorganism [3] and Lancet Infectious Diseases reported the first use of pneumolysin in severe CAP treatment added to standard of care in a phase II trial [4] . Incidence of community-acquired lower respiratory tract infections and pneumonia among older adults in the United Kingdom: a population-based study Incidence rate of community-acquired pneumonia in adults: a population-based prospective active surveillance study in three cities in South America Disease burden and etiologic distribution of community-acquired pneumonia in adults: evolving epidemiology in the era of pneumococcal conjugate vaccines Epidemiology and clinical outcomes of community-acquired pneumonia in adult patients in Asian countries: a prospective study by the Asian network for surveillance of resistant pathogens Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial abstract: Community-acquired pneumonia (CAP) is the leading cause of death among infectious diseases and an important health problem, having considerable implications for healthcare systems worldwide. Despite important advances in prevention through vaccines, new rapid diagnostic tests and antibiotics, CAP management still has significant drawbacks. Mortality remains very high in severely ill patients presenting with respiratory failure or shock but is also high in the elderly. Even after a CAP episode, higher risk of death remains during a long period, a risk mainly driven by inflammation and patient-related co-morbidities. CAP microbiology has been altered by new molecular diagnostic tests that have turned viruses into the most identified pathogens, notwithstanding uncertainties about the specific role of each virus in CAP pathogenesis. Pneumococcal vaccines also impacted CAP etiology and thus had changed Streptococcus pneumoniae circulating serotypes. Pathogens from specific regions should also be kept in mind when treating CAP. New antibiotics for CAP treatment were not tested in severely ill patients and focused on multidrug-resistant pathogens that are unrelated to CAP, limiting their general use and indications for intensive care unit (ICU) patients. Similarly, CAP management could be personalized through the use of adjunctive therapies that showed outcome improvements in particular patient groups. Although pneumococcal vaccination was only convincingly shown to reduce invasive pneumococcal disease, with a less significant effect in pneumococcal CAP, it remains the best therapeutic intervention to prevent bacterial CAP. Further research in CAP is needed to reduce its population impact and improve individual outcomes. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140754/ doi: 10.1007/s12325-020-01248-7 id: cord-295798-x7or932x author: Ferrey, Antoney J. title: A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease date: 2020-03-28 words: 3030.0 sentences: 157.0 pages: flesch: 46.0 cache: ./cache/cord-295798-x7or932x.txt txt: ./txt/cord-295798-x7or932x.txt summary: title: A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease During this interval, he reported nausea, vomiting, diarrhea, and low-grade fevers but was not suspected of COVID-19 infection until he developed respiratory symptoms and was admitted to the hospital. We present a case of COVID-19 in the United States in a long-term dialysis-dependent ESRD patient reported thus far in the 2020 COVID-19 pandemic. The following day the patient traveled by commercial airline from Southern California to Utah where he presented to an emergency department for continued intermittent vomiting and fevers but was now reporting mild congestion and cough. This case report highlights the importance of considering COVID-19 infection in a variety of clinical presentation that may not initially include typical respiratory symptom to prevent ongoing exposure of potentially affected individuals to the general population. abstract: Novel coronavirus disease 2019 (COVID-19) is a highly infectious, rapidly spreading viral disease with an alarming case fatality rate up to 5%. The risk factors for severe presentations are concentrated in patients with chronic kidney disease, particularly patients with end-stage renal disease (ESRD) who are dialysis dependent. We report the first US case of a 56-year-old nondiabetic male with ESRD secondary to IgA nephropathy undergoing thrice-weekly maintenance hemodialysis for 3 years, who developed COVID-19 infection. He has hypertension controlled with angiotensin receptor blocker losartan 100 mg/day and coronary artery disease status-post stent placement. During the first 5 days of his febrile disease, he presented to an urgent care, 3 emergency rooms, 1 cardiology clinic, and 2 dialysis centers in California and Utah. During this interval, he reported nausea, vomiting, diarrhea, and low-grade fevers but was not suspected of COVID-19 infection until he developed respiratory symptoms and was admitted to the hospital. Imaging studies upon admission were consistent with bilateral interstitial pneumonia. He was placed in droplet-eye precautions while awaiting COVID-19 test results. Within the first 24 h, he deteriorated quickly and developed acute respiratory distress syndrome (ARDS), requiring intubation and increasing respiratory support. Losartan was withheld due to hypotension and septic shock. COVID-19 was reported positive on hospital day 3. He remained in critical condition being treated with hydroxychloroquine and tocilizumab in addition to the standard medical management for septic shock and ARDS. Our case is unique in its atypical initial presentation and highlights the importance of early testing. url: https://doi.org/10.1159/000507417 doi: 10.1159/000507417 id: cord-019043-cqmqwl3i author: Fidalgo, Pedro title: Chronic Kidney Disease in the Intensive Care Unit date: 2014-03-08 words: 8675.0 sentences: 409.0 pages: flesch: 32.0 cache: ./cache/cord-019043-cqmqwl3i.txt txt: ./txt/cord-019043-cqmqwl3i.txt summary: The incidence and prevalence of chronic kidney disease (CKD) and end-stage renal disease are increasing, and these patients have a higher risk of developing critical illness and being admitted to the intensive care unit (ICU) compared to the general population. Factors that have been shown to be associated with ICU mortality in ESRD patients are older age, higher illness severity score (i.e., APACHE II or SAPS II), burden of nonrenal organ dysfunction/failure, medical or nonsurgical admission type, and provision and duration of life-sustaining technologies (i.e., mechanical ventilation, vasopressor therapy). Synthetic colloids, such as hydroxyethyl starch (HES), have appeal for resuscitation fluids based on the premise that they attenuate the inflammatory response, mitigate endothelial barrier dysfunction, improve microcirculatory flow, and contribute to more rapid hemodynamic stabilization; however, accumulated data have now suggested use of these fluids in critical illness is associated with dosedependent risk for severe AKI requiring RRT, bleeding complications, and death (Box 32.2). abstract: The incidence and prevalence of chronic kidney disease (CKD) and end-stage renal disease are increasing, and these patients have a higher risk of developing critical illness and being admitted to the intensive care unit (ICU) compared to the general population. The higher prevalence of comorbid disease puts this population at higher risk for worse short- and long-term outcomes following ICU admission compared to the general population, although short-term mortality seems to be determined largely by the acute illness severity rather than CKD status per se. The pathophysiologic changes accompanying CKD present unique challenges to the management of acute critical illness most notably volume and metabolic homeostasis and drug dosing adjustment. CKD is an important risk factor for the development of acute kidney injury (AKI) complicating critical illness and can predispose to further accelerated decline in kidney function among ICU survivors. Renal replacement therapy (RRT) support is frequently used in ICU settings, and continuous renal replacement therapy modality remains the most commonly used among critically ill patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124091/ doi: 10.1007/978-3-642-54637-2_32 id: cord-337262-88qpfu6b author: File, Thomas M. title: 26 Community-Acquired Pneumonia, Bacterial date: 2012-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Community-acquired pneumonia (CAP) is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community and has not had recent hospitalization or association with other healthcare facilities such as nursing homes, dialysis centers, and outpatient clinics. CAP is a common and potentially serious illness, particularly in elderly patients and those with significant comorbidities. CAP may be caused by myriad pathogens, but bacteria are the most common causes. Bacteria have traditionally been divided into two groups: typical and atypical agents. Typical organisms include Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, group A streptococci, Moraxella catarrhalis, anaerobes, and aerobic gram-negative bacteria. Atypical organisms include Legionella species, Mycoplasma pneumoniae, Chlamydophila (also known as Chlamydia) pneumoniae, and Chlamydophila psittaci. This chapter will focus on the general approach to CAP in adults, with a concentration primarily on typical bacterial causes. Other chapters focus specifically on pneumonia caused by aspiration, viruses, or atypical organisms. url: https://www.sciencedirect.com/science/article/pii/B9781437701265000264 doi: 10.1016/b978-1-4377-0126-5.00026-4 id: cord-339009-wcoch07b author: File, Thomas M. title: Severe Acute Respiratory Syndrome: Pertinent Clinical Characteristics and Therapy date: 2012-08-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe acute respiratory syndrome (SARS) is a newly emerged infection that is caused by a previously unrecognized virus–a novel coronavirus designated as SARS-associated coronavirus (SARS-CoV). From November 2002 to July 2003 the cumulative number of worldwide cases was >8000, with a mortality rate of close to 10%. The mortality has been higher in older patients and those with co-morbidities. SARS has been defined using clinical and epidemiological criteria and cases are considered laboratory-confirmed if SARS coronavirus is isolated, if antibody to SARS coronavirus is detected, or a polymerase chain reaction test by appropriate criteria is positive. At the time of writing (24 May 2004), no specific therapy has been recommended. A variety of treatments have been attempted, but there are no controlled data. Most patients have been treated throughout the illness with broad-spectrum antimicrobials, supplemental oxygen, intravenous fluids, and other supportive measures. Transmission of SARS is facilitated by close contact with patients with symptomatic infection. The majority of cases have been reported among healthcare providers and family members of SARS patients. Since SARS-CoV is contagious, measures for prevention center on avoidance of exposure, and infection control strategies for suspected cases and contacts. This includes standard precautions (hand hygiene), contact precautions (gowns, goggles, gloves) and airborne precautions (negative pressure rooms and high efficiency masks). In light of reports of new cases identified during the winter of 2003–4 in China, it seems possible that SARS will be an important cause of pneumonia in the future, and the screening of outpatients at risk for SARS may become part of the pneumonia evaluation. url: https://www.ncbi.nlm.nih.gov/pubmed/15813661/ doi: 10.2165/00151829-200504020-00003 id: cord-333684-j1sg46w9 author: Filippi, Federica title: COVID‐19 era: A chance to learn something new about monitoring psoriatic patients in biological therapy date: 2020-06-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1111/dth.13805 doi: 10.1111/dth.13805 id: cord-225218-x32a4sp3 author: Filntisis, Panagiotis P. title: Identifying differences in physical activity and autonomic function patterns between psychotic patients and controls over a long period of continuous monitoring using wearable sensors date: 2020-10-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Digital phenotyping is a nascent multidisciplinary field that has the potential to revolutionize psychiatry and its clinical practice. In this paper, we present a rigorous statistical analysis of short-time features extracted from wearable data, during long-term continuous monitoring of patients with psychotic disorders and healthy control counterparts. Our novel analysis identifies features that fluctuate significantly between the two groups, and offers insights on several factors that differentiate them, which could be leveraged in the future for relapse prevention and individualized assistance. url: https://arxiv.org/pdf/2011.02285v1.pdf doi: nan id: cord-313349-ikjivfce author: Finsterer, Josef title: Causes of hypogeusia/hyposmia in SARS‐CoV2 infected patients date: 2020-04-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: It is well appreciated that SARS‐CoV2 does not exclusively affect the lungs.(1,2) Virus‐RNA can be detected in most of the body compartments, including the cerebrospinal fluid (CSF).(3) Neurological manifestations have been recently investigated in a retrospective study of 214 SARS‐CoV2‐infected patients.(1) This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/jmv.25903 doi: 10.1002/jmv.25903 id: cord-030149-hkpjnqm9 author: Fioratti, Iuri title: Strategies for a safe and assertive telerehabilitation practice date: 2020-08-07 words: 1804.0 sentences: 125.0 pages: flesch: 35.0 cache: ./cache/cord-030149-hkpjnqm9.txt txt: ./txt/cord-030149-hkpjnqm9.txt summary: Therefore, we have developed a series of practical recommendations that may guide physical therapists throughout the use of technology for the treatment of their patients (Table 1 ). 5, 6 Best practice for chronic musculoskeletal pain includes provision of education/information about the patients'' condition and management strategies and encouragement to pursue physical activity or exercises. 7, 19 Previous studies showed barriers to development of therapeutic alliance related to lack of visual cues and misunderstanding, therefore requiring advanced communication skills from clinicians to ensure best telerehabilitation practice. 17 The evidence on acceptability of remote delivery of interventions for a diverse range of medical conditions (eg, pain management, post-surgery, cardiac and pulmonary conditions) 12,29---31 indicate mostly positive findings, including a feeling of closeness despite the distance, 11 ongoing support from health professionals, 32 and continuous motivation for learning. Presenting clear and practical recommendations for telerehabilitation may empower clinicians to better use technology as an alternative mode of delivering physical therapy. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410814/ doi: 10.1016/j.bjpt.2020.07.009 id: cord-332650-05oz5zwz author: Fiorelli, Silvia title: Perspectives in surgical and anaesthetic management of lung cancer in the era of coronavirus disease 2019 (COVID-19) date: 2020-08-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Early in 2020, coronavirus disease 2019 (COVID-19) quickly spread globally, giving rise to a pandemic. In this critical scenario, patients with lung cancer need to continue to receive optimal care and at the same be shielded from infection with the potentially severe acute respiratory syndrome coronavirus 2. Upgrades to the prevention and control of infection have become paramount in order to lower the risk of hospital contagion. Aerosol-generating procedures such as endotracheal intubation or endoscopic procedures may expose health care workers to a high risk of infection. Moreover, thoracic anaesthesia usually requires highly complex airway management procedures because of the need for one-lung isolation and one-lung ventilation. Therefore, in the current pandemic, providing a fast-track algorithm for scientifically standardized diagnostic criteria and treatment recommendations for patients with lung cancer is urgent. Suggestions for improving existing contagion control guidelines are needed, even in the case of non-symptomatic patients who possibly are responsible for virus spread. A COVID-19-specific intraoperative management strategy designed to reduce risk of infection in both health care workers and patients is also required. url: https://doi.org/10.1093/ejcts/ezaa295 doi: 10.1093/ejcts/ezaa295 id: cord-284995-8lyr3gs4 author: Fiorina, Laurent title: COVID-19 et troubles du rythme date: 2020-10-02 words: 1416.0 sentences: 147.0 pages: flesch: 59.0 cache: ./cache/cord-284995-8lyr3gs4.txt txt: ./txt/cord-284995-8lyr3gs4.txt summary: Les connaissances dans ce domaine sont encore loin d''être exhaustives mais plusieurs séries publiées concernant les patients atteints de la COVID-19 retrouvent une proportion significative de troubles du rythme, dont certains pouvant potentiellement mener à une issue fatale. Sur une série de 146 patients hospitalisés pour la COVID-19, 20% avaient une atteinte myocardique (définie comme une élévation significative de troponine I, avec des signes électrocardiographiques (ECG) compatibles avec une ischémie myocardique) résultant en une J o u r n a l P r e -p r o o f mortalité de 51.2% comparée à 4.5% chez les patients sans atteinte myocardique [2] . Troubles du rythme observés à la phase aigüe : Description -Les palpitations étaient un symptôme de présentation initial de la maladie chez 7.3% des patients hospitalisés pour la COVID-19 dans une série de Wuhan en Chine [7] . abstract: Lors de la pandémie due au virus SARS-CoV2 les troubles du rythme n’ont pas été au premier plan. Cependant le virus semble atteindre de nombreux organes et le tropisme cardiaque est maintenant bien connu. Les connaissances dans ce domaine sont encore loin d’être exhaustives mais plusieurs séries publiées concernant les patients atteints de la COVID-19 retrouvent une proportion significative de troubles du rythme, dont certains pouvant potentiellement mener à une issue fatale. Ces troubles du rythme sont principalement supra-ventriculaires à type de fibrillation atriale (FA) ou flutter mais également ventriculaire avec des tachycardies ventriculaires (TV) fibrillation ventriculaire (FV) et plus rarement torsades de pointe (TdP). Les causes en sont multiples du fait de l’atteinte multi-organe du virus et des interactions médicamenteuses potentielles. Par ailleurs la question de la surveillance de troubles du rythme pouvant émerger à moyen et long terme après une infection reste à explorer. In the pandemic caused by the SARS-CoV2 virus, arrhythmias were not in the foreground. However, the virus seems to affect many organs and the cardiac tropism is now well known. Knowledge in this area is still far from exhaustive, but several series published concerning patients with COVID-19 find a significant proportion of arrhythmias, some of which can potentially lead to a fatal outcome. These rhythm disorders are mainly supra-ventricular such as atrial fibrillation (AF) or flutter but also ventricular disorders like ventricular tachycardias (VT) ventricular fibrillation (VF) and more rarely torsades de pointe (TdP). The causes are multiple, due to the multi-organ damage caused by the virus and potential drug interactions. In addition, the question of monitoring rhythm disorders that may emerge in the medium and long term after an infection remains to be explored. url: https://api.elsevier.com/content/article/pii/S0003392820301517 doi: 10.1016/j.ancard.2020.09.042 id: cord-292493-lx7zfgoi author: Firstenberg, Michael S. title: Isolation protocol for a COVID-2019 patient requiring emergent surgical intervention: case presentation date: 2020-04-19 words: 2352.0 sentences: 116.0 pages: flesch: 50.0 cache: ./cache/cord-292493-lx7zfgoi.txt txt: ./txt/cord-292493-lx7zfgoi.txt summary: Few specific guidelines are available to outline the steps necessary to adequately maintain appropriate isolation precautions in patients who require emergent surgical interventions and who are either confirmed SARS-CoV2 or who are awaiting the results of testing. The purpose of this discussion is to outline the steps our U.S. institution undertook in managing a patient who required emergent cardiac surgery for an acute aortic syndrome who was presumptively infected, and did test positive on post-operative day two. Given the findings of pulmonary infiltrates, upon admission, he was placed in strict droplet and contact precautions in a negative air-flow Intensive Care Unit (ICU) room as a potential COVID-2019 case. Written surgical and anesthesia consent was obtained by the operating surgeon and anesthesiologist wearing appropriate personal protective equipment (PPE) that included N-95 mask, face shield, gown, and gloves). abstract: BACKGROUND: The concerns of the highly contagious and morbid nature of Coronavirus Disease-2019 (COVID-2019) have prompted healthcare workers to implement strict droplet and contact isolation precautions. Unfortunately, some patients who may be or presumptively or confirmed as infected with COVID-2019 may also require emergent surgical procedures. As such, given the high-risk for exposure of many healthcare workers involved the complex requirements for appropriate isolation must be adhered to. CASE PRESENTATION: We present our experience with a 77-year-old who required emergency cardiac surgery for a presumed acute aortic syndrome in the setting of a presumed, and eventually confirmed, COVID-2019 infection. We outline the necessary steps to maintain strict isolation precautions to limit potential exposure to the surgical Team. CONCLUSIONS: We hereby provide our algorithm for emergent surgical procedures in critically-ill patients with presumptive or confirmed infection with COVID-2019. The insights from this case report can potentially be templated to other facilities in order to uphold high standards of infection prevention and patient safety in surgery during the current COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32328170/ doi: 10.1186/s13037-020-00243-9 id: cord-258133-zsweppku author: Fischer, M. title: COVID-19 paranoia in a patient suffering from schizophrenic psychosis – a case report date: 2020-04-17 words: 1125.0 sentences: 59.0 pages: flesch: 48.0 cache: ./cache/cord-258133-zsweppku.txt txt: ./txt/cord-258133-zsweppku.txt summary: Here we report the case of a patient with schizophrenia presenting with COVD-19related delusions and hallucinations, illustrating the potential of COVID-19 to precipitate entry into a psychotic phase and impact symptom manifestation. This case report shows the impact of the COVID-19 crisis on the psychopathology of a patient with paranoid psychosis leading to the outbreak of a psychotic phase with paranoid-hallucinatoric experiencing and unrealistic expectations and concerns. This observation may be in line with the previous reports that higher levels of concurrent anxiety in patients with schizophrenia correlated with lower perception of personal risk of infection with swine flu, although the reason for this effect is unclear (Maguire et al., 2019a) . Overall, the current case report illustrates the potential for the psychological context of the COVID-19 emergency to influence emergence and manifestations of symptoms of psychosis, and indicates that measured, balanced and responsible reporting of the COVID-19 crisis in the media will be important to minimize the risk of overreactions in at risk persons and to avoid entry into psychotic episodes. abstract: nan url: https://api.elsevier.com/content/article/pii/S0165178120306673 doi: 10.1016/j.psychres.2020.113001 id: cord-318312-v1c3qm7h author: Fischer, Quentin title: Case report of anterior ST-elevation myocardial infarction in a patient with coronavirus disease-2019 date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease-2019 (COVID-19) is an infectious disease appeared in China in December 2019 and, since then, has spread worldwide at a rapid pace. CASE SUMMARY: A patient with COVID-19 was hospitalized in our institution for a diabetic foot ulcer and presented afterwards a pulmonary oedema and concomitant anterior ST-segment elevation myocardial infarction. We report here on the initial presentation, coronary care and intervention, and clinical course of this patient. DISCUSSION: Emergent percutaneous coronary intervention is feasible and safe in COVID-19 patients but requires a multidisciplinary effort involving caregivers from infectious disease, intensive care, and cardiology teams. url: https://www.ncbi.nlm.nih.gov/pubmed/33089044/ doi: 10.1093/ehjcr/ytaa131 id: cord-265278-wf5pbvvt author: Fishman, Jay A. title: Case 29-2020: A 66-Year-Old Man with Fever and Shortness of Breath after Liver Transplantation date: 2020-09-17 words: 5266.0 sentences: 317.0 pages: flesch: 40.0 cache: ./cache/cord-265278-wf5pbvvt.txt txt: ./txt/cord-265278-wf5pbvvt.txt summary: In transplant recipiAfter infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viral replication ensues in the respiratory epithelium, followed by viremia and systemic spread to organs by means of the angiotensin-converting-enzyme 2 receptor. 22 Graft rejection and toxic effects from calcineurin inhibitors may be difficult to distinguish from The varied presentation of SARS-CoV-2 infection reflects diversity in host immune responses, notably in immunosuppressed transplant recipients. Although the use of antiinflammatory drugs (e.g., high-dose glucocorticoids or interleukin-6 receptor antagonists) in solid-organ transplant recipients may have the additional benefit of protecting against rejection among patients who are receiving tapering courses of the immunosuppressive agents, especially when calcineurin inhibitors are discontinued because of severe disease, their efficacy in the context of solidorgan transplantation warrants testing in clinical trials. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32937051/ doi: 10.1056/nejmcpc2004982 id: cord-274563-jimw6skv author: Fiumara, Agata title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 words: 3524.0 sentences: 163.0 pages: flesch: 50.0 cache: ./cache/cord-274563-jimw6skv.txt txt: ./txt/cord-274563-jimw6skv.txt summary: During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. Methods: Based on the feeling that our patients were experiencing profound distress, we designed a structured telephone interview with the aim to evaluate how, and to which extent, the pandemic outbreak was changing their behavior and feelings about their chronic disease, the impact on therapies, and future expectations. Moreover, a striking similarity emerged between the groups regarding forced home reclusion and the profound feeling to be excluded by normal life, well-known to those affected by a chronic rare disease. Based on the feeling that our patients were experiencing profound distress, we designed a structured interview [3, 4] with the aim to evaluate how, and to which extent, the COVID-19 pandemic was changing our patients'' behavior and feelings about their chronic disease, the impact on therapies, and their future expectations. abstract: Background: Lysosomal storage disorders (LSDs) are rare, chronic, progressive multisystem diseases implying severe medical issues and psychological burden. Some of these disorders are susceptible to a treatment, which is administered weekly or every other week, in a hospital. During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. Methods: Based on the feeling that our patients were experiencing profound distress, we designed a structured telephone interview with the aim to evaluate how, and to which extent, the pandemic outbreak was changing their behavior and feelings about their chronic disease, the impact on therapies, and future expectations. The same interview was administered to an age-matched control group. Results: All interviewed people experienced an increase of anxiety, worries, and uncertainty fostered by incessant media updates. Moreover, a striking similarity emerged between the groups regarding forced home reclusion and the profound feeling to be excluded by normal life, well-known to those affected by a chronic rare disease. Conclusions: Although no statistically significant difference was found compared to controls, we felt that the reactions were qualitatively different, underlining the fragility and isolation of such patients. url: https://doi.org/10.3390/jcm9092716 doi: 10.3390/jcm9092716 id: cord-289046-frhpt8n9 author: Fix, Oren K. title: Telemedicine and Telehepatology During the COVID‐19 Pandemic date: 2020-05-21 words: 1474.0 sentences: 87.0 pages: flesch: 51.0 cache: ./cache/cord-289046-frhpt8n9.txt txt: ./txt/cord-289046-frhpt8n9.txt summary: The Coronavirus Preparedness and Response Supplemental Appropriations Act (H.R. 6074) was signed into law on March 6, 2020, and provides a temporary waiver of many of the CMS restrictions and requirements regarding telemedicine services during the COVID-19 public health emergency. When these barriers to telemedicine were removed, providers, hospitals, and health systems rapidly embraced telemedicine or scaled up existing programs to meet the sudden demand for remote, synchronous patient care. Some patients with new physical symptoms or recent hepatic decompensation are best evaluated in person but may avoid seeking medical care due to social distancing policies or concerns about exposure to COVID-19 in the health care setting. For established patients with decompensated liver disease, review telemedicine can offer rapid evaluation and avoid the need for an in-person appointment when, for example, adjusting diuretics or medications for hepatic encephalopathy. As we look to a future beyond the COVID-19 pandemic, we have an opportunity to consider telemedicine''s place in the routine delivery of patient care. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32537134/ doi: 10.1002/cld.971 id: cord-351735-x1lng449 author: Flikweert, Antine W. title: Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Pathological data of critical ill COVID-19 patients is essential in the search for optimal treatment options. MATERIAL AND METHODS: We performed postmortem needle core lung biopsies in seven patients with COVID-19 related ARDS. Clinical, radiological and microbiological characteristics are reported together with histopathological findings. MEASUREMENT AND MAIN RESULTS: Patients age ranged from 58 to 83 years, five males and two females were included. Time from hospital admission to death ranged from 12 to 36 days, with a mean of 20 ventilated days. ICU stay was complicated by pulmonary embolism in five patients and positive galactomannan on bronchoalveolar lavage fluid in six patients, suggesting COVID-19 associated pulmonary aspergillosis. Chest CT in all patients showed ground glass opacities, commonly progressing to nondependent consolidations. We observed four distinct histopathological patterns: acute fibrinous and organizing pneumonia, diffuse alveolar damage, fibrosis and, in four out of seven patients an organizing pneumonia. None of the biopsy specimens showed any signs of invasive aspergillosis. CONCLUSIONS: In this case series common late histopathology in critically ill COVID patients is not classic DAD but heterogeneous with predominant pattern of organizing pneumonia. Postmortem biopsy investigations in critically COVID-19 patients with probable COVID-19 associated pulmonary aspergillosis obtained no evidence for invasive aspergillosis. url: https://www.sciencedirect.com/science/article/pii/S0883944120306031?v=s5 doi: 10.1016/j.jcrc.2020.07.002 id: cord-345028-56hg62be author: Flinspach, Armin Niklas title: Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients—A Case Series and Systematic Review date: 2020-10-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The ongoing coronavirus pandemic is challenging, especially in severely affected patients who require intubation and sedation. Although the potential benefits of sedation with volatile anesthetics in coronavirus disease 2019 patients are currently being discussed, the use of isoflurane in patients with coronavirus disease 2019–induced acute respiratory distress syndrome has not yet been reported. DESIGN: We performed a retrospective analysis of critically ill patients with hypoxemic respiratory failure requiring mechanical ventilation. SETTING: The study was conducted with patients admitted between April 4 and May 15, 2020 to our ICU. PATIENTS: We included five patients who were previously diagnosed with severe acute respiratory syndrome coronavirus 2 infection. INTERVENTION: Even with high doses of several IV sedatives, the targeted level of sedation could not be achieved. Therefore, the sedation regimen was switched to inhalational isoflurane. Clinical data were recorded using a patient data management system. We recorded demographical data, laboratory results, ventilation variables, sedative dosages, sedation level, prone positioning, duration of volatile sedation and outcomes. MEASUREMENTS & MAIN RESULTS: Mean age (four men, one women) was 53.0 (± 12.7) years. The mean duration of isoflurane sedation was 103.2 (± 66.2) hours. Our data demonstrate a substantial improvement in the oxygenation ratio when using isoflurane sedation. Deep sedation as assessed by the Richmond Agitation and Sedation Scale was rapidly and closely controlled in all patients, and the subsequent discontinuation of IV sedation was possible within the first 30 minutes. No adverse events were detected. CONCLUSIONS: Our findings demonstrate the feasibility of isoflurane sedation in five patients suffering from severe coronavirus disease 2019 infection. Volatile isoflurane was able to achieve the required deep sedation and reduced the need for IV sedation. url: https://doi.org/10.1097/cce.0000000000000256 doi: 10.1097/cce.0000000000000256 id: cord-289854-p8okfa4b author: Flores, Gabriel title: Spontaneous Brainstem Hemorrhagic Stroke in the Setting of Novel Coronavirus Disease 2019 – A Case Report date: 2020-10-05 words: 1422.0 sentences: 90.0 pages: flesch: 44.0 cache: ./cache/cord-289854-p8okfa4b.txt txt: ./txt/cord-289854-p8okfa4b.txt summary: In this report, we outline the clinical presentation of a 40-year-old male who developed severe coughing and sneezing before presenting to the emergency department with confusion, somnolence, and respiratory distress. On hospital day four, his neurological examination deteriorated to quadriparesis and only cough and gag reflexes remaining intact after which his family opted for comfort measures only. Since initial reports in December 2019 from Wuhan, China, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus two (SARS-CoV-2) has become a global pandemic. Our patient is a 40-year-old male with past medical history of obesity, hypertension, and type two diabetes mellitus who developed severe coughing and sneezing before presenting to the emergency department with confusion, somnolence, and respiratory distress. Severe cough was reported to cause cerebral hemorrhage in patients with whooping cough as early as 1885 [8] . Increased risk of intracerebral hemorrhage adds to the complexity of management of patients with COVID-19. abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has become a global pandemic. This disease has been shown to affect various organ systems, including the cerebrovascular system with sequelae still not completely uncovered. We present an unusual case of extensive brainstem intraparenchymal hemorrhage in a patient with COVID-19 to caution readers of this possible complication in patients positive for COVID-19. In this report, we outline the clinical presentation of a 40-year-old male who developed severe coughing and sneezing before presenting to the emergency department with confusion, somnolence, and respiratory distress. CT head without contrast revealed extensive pontine and midbrain hemorrhage with intraventricular extension and early hydrocephalus. Neurological examination revealed pinpoint, minimally reactive pupils, withdrawal to painful stimuli in the right hemibody, left hemibody paresis, and intact left corneal, cough, and gag reflexes. MRI and MRA brain revealed no evidence of an underlying vascular lesion. Over the next two days, the patient had worsening multiorgan failure and hypoxemia without intracranial hypertension. He remained too unstable to undergo cerebral angiogram. On hospital day four, his neurological examination deteriorated to quadriparesis and only cough and gag reflexes remaining intact after which his family opted for comfort measures only. In summary, a potential increased risk of intracerebral hemorrhage adds to the complexity of management of patients with COVID-19. This is especially true in those who have violent sneezing or coughing, or those who are on anticoagulation or antiplatelet therapy. url: https://doi.org/10.7759/cureus.10809 doi: 10.7759/cureus.10809 id: cord-355264-ygzh8von author: Florez-Perdomo, William Andrés title: Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: a systematic review and meta-analysis date: 2020-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND AND OBJECTIVES: Past history of stroke has been associated with an increased risk of a new ischemic stroke. Several studies have indicated increased prevalence of strokes among coronavirus patients. However, the role of past history of stroke in COVID19 patients is still unclear. The purpose of this systematic review is to evaluate and summarize the level of evidence on past history of stroke in COVID19 patients METHODS: A systematic review was performed according to the PRISMA guidelines was performed in PubMed, Embase, EBSCO Host, Scopus, Science Direct, Medline, and LILACS. Eligibility criteria: We evaluated studies including patients with diagnosis of COVID 19 and a past history of stroke. Risk of bias: was evaluated with the Newcastle- Ottawa Scale (NOS) and experimental studies were evaluated using the ROBINS-I scale RESULTS: Seven articles out of the total 213 articles were evaluated and included, involving 3244 patients with SARS VOC 2 Disease (COVID19) of which 198 had a history of cerebrovascular disease. Meta-analysis of the data was performed, observing an increase in mortality in patients with a history of cerebrovascular disease compared to those with different comorbidities or those without underlying pathology (OR 2.78 95% CI [1.42- 5.46] p = 0.007; I(2) = 49%) showing adequate heterogeneity. The presence of publication bias was evaluated using the Egger test in a funnel plot, showing adequate. asymmetry, indicating that there is no publication bias; however, due to the low number of included studies, we could not rule out or confirm the presence of bias. CONCLUSIONS: The history of cerebrovascular disease was associated with a 2.78-fold increased risk of mortality compared to patients with other comorbidities or without underlying pathologies. url: https://doi.org/10.1016/j.clineuro.2020.106183 doi: 10.1016/j.clineuro.2020.106183 id: cord-017784-4r3fpmlb author: Foccillo, Giampiero title: The Infections Causing Acute Respiratory Failure in Elderly Patients date: 2019-08-06 words: 3573.0 sentences: 170.0 pages: flesch: 31.0 cache: ./cache/cord-017784-4r3fpmlb.txt txt: ./txt/cord-017784-4r3fpmlb.txt summary: Severe community-acquired pneumonia and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are causes of acute respiratory failure (ARF) in elderly patients. This process termed immunosenescence or immune dysregulation, together changes in lung function who occur with advancing age, play a critical role in the manifestation of age-related pulmonary diseases such as infections (i.e., pneumonia), chronic obstructive pulmonary disease (COPD), and increased the risk for develop sepsis [1] . Triggering causes of ARF in advanced aged patients are especially acute heart decompensation, severe community-acquired pneumonia (CAP), acute exacerbations of COPD (AECOPD), and pulmonary embolism. Lower respiratory tract infections, including pneumonia and exacerbation of chronic obstructive pulmonary disease, are among the most common causes of ARF in elderly people and the most important cause of hospitalization. Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease abstract: The immune system of older individuals declines with advancing age (“immunosenescence”) increasing susceptibility to infection, as well as to an increased risk of a worse outcome. Severe community-acquired pneumonia and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are causes of acute respiratory failure (ARF) in elderly patients. Non-invasive mechanical ventilation (NIV) is effective in the treatment of patients with ARF, above all in case of AECOPD. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122443/ doi: 10.1007/978-3-030-26664-6_5 id: cord-319013-oytqcifa author: Focosi, Daniele title: Convalescent Plasma Therapy for COVID-19: State of the Art date: 2020-08-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Convalescent plasma (CP) therapy has been used since the early 1900s to treat emerging infectious diseases; its efficacy was later associated with the evidence that polyclonal neutralizing antibodies can reduce the duration of viremia. Recent large outbreaks of viral diseases for which effective antivirals or vaccines are still lacking has renewed the interest in CP as a life-saving treatment. The ongoing COVID-19 pandemic has led to the scaling up of CP therapy to unprecedented levels. Compared with historical usage, pathogen reduction technologies have now added an extra layer of safety to the use of CP, and new manufacturing approaches are being explored. This review summarizes historical settings of application, with a focus on betacoronaviruses, and surveys current approaches for donor selection and CP collection, pooling technologies, pathogen inactivation systems, and banking of CP. We additionally list the ongoing registered clinical trials for CP throughout the world and discuss the trial results published thus far. url: https://www.ncbi.nlm.nih.gov/pubmed/32792417/ doi: 10.1128/cmr.00072-20 id: cord-263055-4f25h9l4 author: Fogarty, Helen title: More on COVID‐19 coagulopathy in Caucasian patients date: 2020-05-25 words: 1191.0 sentences: 67.0 pages: flesch: 39.0 cache: ./cache/cord-263055-4f25h9l4.txt txt: ./txt/cord-263055-4f25h9l4.txt summary: We are grateful for the comments of Marrietta et al, [1] and welcome the opportunity to provide further details on the coagulopathy observed in our patients with COVID-19 infection [2]. The weight-adjusted low molecular weight heparin (LMWH) thromboprophylaxis used in the study is that routinely used for hospital in-patients in our institution, consistent with national recommendations [3,4] With respect to the cohort of patients with COVID-19 enrolled in our study, it is important to highlight that 74% of patients received enoxaparin 40mg (4000 IU) subcutaneously once daily. This hypothesis is supported by emerging data suggesting that the incidence of thrombotic complications in critically ill patients with COVID-19 may be >30%, even in patients receiving LMWH thromboprophylaxis. From the literature, it is clear that other centres have already elected to institute increased LMWH doses for selected patients with severe COVID-19 infection. abstract: We are grateful for the comments of Marrietta et al, [1] and welcome the opportunity to provide further details on the coagulopathy observed in our patients with COVID-19 infection [2]. The weight-adjusted low molecular weight heparin (LMWH) thromboprophylaxis used in the study is that routinely used for hospital in-patients in our institution, consistent with national recommendations [3,4] With respect to the cohort of patients with COVID-19 enrolled in our study, it is important to highlight that 74% of patients received enoxaparin 40mg (4000 IU) subcutaneously once daily. url: https://www.ncbi.nlm.nih.gov/pubmed/32400024/ doi: 10.1111/bjh.16791 id: cord-279238-d49jvws2 author: Folesani, Gianluca title: Cardiac surgery model during COVID-19 pandemic: now it’s time to ramp up date: 2020-07-09 words: 504.0 sentences: 39.0 pages: flesch: 62.0 cache: ./cache/cord-279238-d49jvws2.txt txt: ./txt/cord-279238-d49jvws2.txt summary: The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) spread rapidly from China 1 worldwide and on March 11 th 2020 the WHO declared the so-called COVID-19 a pandemic. All kind of Surgery Units stopped to treat elective cases focusing on urgent/emergent patients to minimize Intensive Care Unit beds utilization. Patients with underlying cardiovascular diseases have an increased risk of developing into the severe form of COVID-19 4 , while health-care workers are exposed to the risk of contagion or to become vectors of transmission. Emilia-Romagna is the third Region for the number of infections, after Lombardy and Piedmont, and the S.Orsola Hospital, University of Bologna, became the main regional Hub center for COVID-19. Actually, in our center, each patient undergoes nasopharingeal swab one day before the hospitalization. If there''s an emergent case, a nasopharingeal swab is performed and the patient is considered suspect until the result of the test. abstract: nan url: https://api.elsevier.com/content/article/pii/S000349752031119X doi: 10.1016/j.athoracsur.2020.07.001 id: cord-273695-p5p7kvpp author: Fominskiy, Evgeny V. title: Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy date: 2020-07-13 words: 3510.0 sentences: 205.0 pages: flesch: 54.0 cache: ./cache/cord-273695-p5p7kvpp.txt txt: ./txt/cord-273695-p5p7kvpp.txt summary: title: Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy BACKGROUND: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. OBJECTIVE: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. The present study aimed to assess the prevalence, patient characteristics clinical outcomes, and predictors of AKI and need of RRT in patients with COVID-19 receiving mechanical ventilation in the intensive care unit (ICU). This is the first report on the prevalence, patient characteristics, risk factors for, and outcome of AKI among COVID-19 patients receiving invasive ventilation in the ICU of a large tertiary hospital in a Western healthcare system. abstract: BACKGROUND: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. OBJECTIVE: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. METHODS: Observational study in a tertiary care hospital in Milan, Italy. RESULTS: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. CONCLUSIONS: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality. url: https://doi.org/10.1159/000508657 doi: 10.1159/000508657 id: cord-016498-j72vrvqf author: Fong, I. W. title: Issues in Community-Acquired Pneumonia date: 2020-03-07 words: 8280.0 sentences: 372.0 pages: flesch: 38.0 cache: ./cache/cord-016498-j72vrvqf.txt txt: ./txt/cord-016498-j72vrvqf.txt summary: In a recent study of 70 children <5 years of age hospitalized for CAP without an identifiable etiology and 90 asymptomatic controls, metagenomics [next-generation sequencing] and pan-viral PCR were able to identify a putative pathogen in 34% of unidentifiable cases from nasopharyngeal and oropharyngeal swabs [18] . More recently in Britain, 325 adult patients with confirmed pneumonia admitted to two tertiary-care hospitals had cultures and comprehensive molecular testing [multiplex real-time PCR for 26 respiratory viruses and bacteria] from sputum [96%] and endotracheal aspirate [4% or 13 cases] [32] . Incidence of respiratory viral infections detected by PCR and real-time PCR in adult patients with community-acquired pneumonia: a meta-analysis Severe thinness is associated with mortality in patients with community-acquired pneumonia: a prospective observational study Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial abstract: Pneumonia is one of the most commonly diagnosed infectious diseases and is the third most frequent cause of death worldwide. Accurate statistics of community-acquired pneumonia incidence globally or in countries of various regions are lacking. Although the clinical diagnosis of pneumonia is not difficult, the etiology diagnosis to guide targeted specific antimicrobial therapy still poses a challenge even with novel molecular methods. This has led to different approaches and guidelines for the empiric treatment of community-acquired pneumonia, often with broad-spectrum antimicrobial agents which may play a role in fostering the worldwide development of antibiotic resistant bacteria. Severe community-acquired pneumonia, seen mainly at the extremes of age and in persons with chronic underlying diseases, is associated with high mortality of 20–40%. Pneumonia severity tools, such as CURB-65, have been developed over the past decade to assist emergency department physicians to recognize, admit, and implement rapid antimicrobial therapy in severely ill patients. The evidence for the beneficial effects of these tools will be reviewed in this chapter. Issues in the management of severe community-acquired pneumonia that are discussed include: combination with newer macrolides [irrespective of microbial etiology], value of adjunctive therapy such as corticosteroids and statins. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120789/ doi: 10.1007/978-3-030-36966-8_3 id: cord-016982-qt25tp6t author: Fong, I. W. title: Litigations for Unexpected Adverse Events date: 2010-11-30 words: 8372.0 sentences: 453.0 pages: flesch: 48.0 cache: ./cache/cord-016982-qt25tp6t.txt txt: ./txt/cord-016982-qt25tp6t.txt summary: The statement of claim alleged the following: (1) isoniazid was directly responsible for the plaintiff''s fulminant hepatitis which resulted in the need for a liver transplant, (2) informed consent was never obtained to prescribe the drug, as the plaintiff was never counseled on the adverse effects, nor given a choice of treatment, (3) use of the isoniazid was never indicated, as the patient had no symptoms or signs of active disease, (4) the physician should have realized that the positive Mantoux test was due to a previous BCG vaccination as a child (the defendant was informed of this fact) and therefore there was no need to treat the plaintiff for latent tuberculosis. abstract: A 53-year-old Iranian female who immigrated to Canada about 3.5 years before was referred to an internist for a positive Mantoux skin test (11 mm in diameter). The subject was previously well with no symptoms indicative or suggestive of active tuberculosis. A routine tuberculosis skin test was performed because the patient had applied to be a volunteer at a local hospital. She had no significant past illness or known allergies, and she was never diagnosed with nor had known contact with anyone with active tuberculosis. The subject never ingested alcohol and was not known to have hepatitis or be a carrier of any hepatitis virus. Baseline investigations performed by the internist included routine complete blood count, routine biochemical tests (liver enzymes, creatinine, and glucose), serum ferritin, and thyroid-stimulating hormone – all of which were normal. A chest radiograph was reported to be normal. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121427/ doi: 10.1007/978-1-4419-8053-3_8 id: cord-270763-idkylpb6 author: Fontes, Cristina Asvolinsque Pantaleão title: Influenza A virus H1N1 associated pneumonia - acute and late aspects evaluated with high resolution tomography in hospitalized patients date: 2020-09-30 words: 3927.0 sentences: 193.0 pages: flesch: 45.0 cache: ./cache/cord-270763-idkylpb6.txt txt: ./txt/cord-270763-idkylpb6.txt summary: The purpose of this study was to review the acute and late phase pulmonary findings in influenza A(H1N1) associated pneumonia using high resolution computed tomography (HRCT), and to determine the importance of performing end expiration series. RESULTS: Ground glass opacities, consolidations, and the combination of both were associated with the acute phase, whereas persistence or worsening of the lesions, lesion improvement, and air trapping in the end expiration series (as seen using HRCT, n=6) were observed in the late phase. In this study, the findings were divided according to the acute and late (10 days to 4 months after first onset of respiratory symptoms) phases of the disease, in patients with persistent pulmonary complaints. The images obtained in our study in patients with influenza A (H1N1) pneumonia included areas of consolidation and/or ground glass opacities, unilateral or bilateral findings, and predominated at the periphery of the lungs. abstract: BACKGROUND: Influenza A (H1N1) virus often compromises the respiratory tract, leading to pneumonia, which is the principal cause of death in these patients. The purpose of this study was to review the acute and late phase pulmonary findings in influenza A(H1N1) associated pneumonia using high resolution computed tomography (HRCT), and to determine the importance of performing end expiration series. METHODS: Between July and August 2009, 140 patients presented with influenza A (H1N1) confirmed by real-timepolymerase chain reaction. Out of these, 27 patients underwent HRCT in the acute and late phases of pneumonia, allowing for a comparative study. Late phase exams were performed due to clinical worsening and up to 120 days later in patients with persistent complaints of dyspnea. RESULTS: Ground glass opacities, consolidations, and the combination of both were associated with the acute phase, whereas persistence or worsening of the lesions, lesion improvement, and air trapping in the end expiration series (as seen using HRCT, n=6) were observed in the late phase. CONCLUSIONS: In the HRCT end expiration series, air trapping was found in the late phase of H1N1 associated pneumonia. Generally, these exams are not evaluated in research articles, and air trapping has not previously been studied using the end expiration series. Our study brings more scientific knowledge about aspects of pulmonary involvement by influenza A (H1N1), through evaluation with end expiration series, which makes the CT exam dynamic, translating the respiratory movement, and showing bronchial alteration. url: https://www.ncbi.nlm.nih.gov/pubmed/33117533/ doi: 10.4081/mrm.2020.692 id: cord-026031-hnf5vayd author: Ford, Richard B. title: Emergency Care date: 2009-05-21 words: 112343.0 sentences: 6645.0 pages: flesch: 44.0 cache: ./cache/cord-026031-hnf5vayd.txt txt: ./txt/cord-026031-hnf5vayd.txt summary: Fresh whole blood Coagulopathy with active hemorrhage (disseminated intravascular coagulation, thrombocytopenia; massive acute hemorrhage; no stored blood available) Stored whole blood Massive acute or ongoing hemorrhage; hypovolemic shock caused by hemorrhage that is unresponsive to conventional crystalloid and colloid fluid therapy; unavailability of equipment required to prepare blood components Packed red blood cells Nonregenerative anemia, immune-mediated hemolytic anemia, correction of anemia before surgery, acute or chronic blood loss Fresh frozen plasma Factor depletion associated with active hemorrhage (congenital: von Willebrand''s factor, hemophilia A, hemophilia B; acquired: vitamin K antagonist, rodenticide intoxication, DIC); acute or chronic hypoproteinemia (burns, wound exudates, body cavity effusion; hepatic, renal, or gastrointestinal loss); colostrum replacement in neonates Frozen plasma Acute plasma or protein loss; chronic hypoproteinemia; (contains stable colostrum replacement in neonates; hemophilia B and clotting factors) selected clotting factor deficiencies Platelet-rich plasma* Thrombocytopenia with active hemorrhage (immune-mediated thrombocytopenia, DIC); platelet function abnormality (congenital: thrombasthenia in Bassett hounds; acquired: NSAIDs, other drugs) Cryoprecipitate abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271342/ doi: 10.1016/b0-72-160138-3/50002-3 id: cord-344131-e7phs0jd author: Ford, Richard B. title: Section 4 Diagnostic and Therapeutic Procedures date: 2012-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/B9781437707984000049 doi: 10.1016/b978-1-4377-0798-4.00004-9 id: cord-023913-pnjhi8cu author: Foreman, Stephen title: Broader Considerations of Medical and Dental Data Integration date: 2011-10-08 words: 47663.0 sentences: 2231.0 pages: flesch: 44.0 cache: ./cache/cord-023913-pnjhi8cu.txt txt: ./txt/cord-023913-pnjhi8cu.txt summary: So while there has been no shortage of effort paid to improving Medicare, the one common theme in all of the recent initiatives is that dental care has been conspicuously 1 A new study by Hedlund, Jeffcoat, Genco and Tanna funded by CIGNA of patients with Type II diabetes and periodontal disease found that medical costs of patients who received maintenance therapy were $2483.51 per year lower than patients who did not. Examples of integrated care models do exist, such as that presented by (Heuer 2007 ) involving school-linked and school-based clinics with an "innovative health infrastructure." According to Heuer, "Neighborhood Outreach Action for Health (NOAH)" is staffed by two nurse practitioners and a part-time physician to provide "primary medical services to more than 3,200 uninsured patients each year" in Scottsdale, Arizona. abstract: Dental health insurance coverage in the United States is either nonexistent (Medicare and the uninsured), spotty (Medicaid) and limited (most employer-based private benefit plans). Perhaps as a result, dental health in the United States is not good. What public policy makers may not appreciate is that this may well be impacting medical care costs in a way that improved dental benefits would produce a substantial return to investment in expanded dental insurance coverage. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177026/ doi: 10.1007/978-1-4471-2185-5_4 id: cord-325863-3t73v4ng author: Foss, Francine M. title: Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant patient on Ruxolitinib date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has a high death rate in patients with comorbidities or in an immunocompromised state. We report a mild and attenuated SARS CoV-2 infection in a patient who is 17 months post stem cell transplantation and maintained on the JAK/STAT inhibitor ruxolitinib, a proposed novel therapy for SARS CoV-2 pneumonia. url: https://www.sciencedirect.com/science/article/pii/S2152265020303128?v=s5 doi: 10.1016/j.clml.2020.06.014 id: cord-347105-my9nioko author: Foster, Carolyn C. title: Integrated Multimodality Telemedicine to Enhance In-Home Care of Infants During the Interstage Period date: 2020-10-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Performing interstage home monitoring using digital platforms (teleIHM) is becoming commonplace but, when used alone, may still require frequent travel for in-person care. We evaluated the acceptability, feasibility, and added value of integrating teleIHM with synchronous telemedicine video visits (VVs) and asynchronous video/photo sharing (V/P) during the interstage period. We conducted a descriptive program evaluation of patient-families receiving integrated multimodality telemedicine (teleIHM + VV + V/P) interstage care from 7/15/2018 to 05/15/2020. First, provider focus groups were conducted to develop a program logic model. Second, patient characteristics and clinical course were reviewed and analyzed with univariate statistics. Third, semi-structured qualitative interviews of family caregivers’ experiences were assessed using applied thematic analysis. Within the study period, 41 patients received teleIHM + VV + V/P care, of which 6 were still interstage and 4 died. About half (51%) of patients were female and 54% were a racial/ethnic minority. Median age was 42 days old (IQR 25, 58) at interstage start, with a median of 113 total days (IQR 72, 151). A total of 551 VVs were conducted with a median 12 VVs (IQR 7, 18) per patient. Parents sent a median 2 pictures (IQR 0–3, range 0–82). Qualitatively, families reported an adjustment period to teleIHM, but engaged favorably with telemedicine overall. Families felt reassured by the oversight routine telemedicine provided and identified logistical and clinical value to VVs above teleIHM alone, while acknowledging trade-offs with in-person care. Integration of multimodality telemedicine is a feasible and acceptable approach to enhance in-home care during the interstage period. url: https://www.ncbi.nlm.nih.gov/pubmed/33079264/ doi: 10.1007/s00246-020-02489-7 id: cord-019064-e5z92vg8 author: Fox, Robert I. title: Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations date: 2011-04-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Primary Sjögren’s syndrome (1° SS) is an autoimmune disorder characterized by dry eyes (keratoconjunctivitis sicca) and dry mouth due to lymphocytic infiltrates of lacrimal and salivary glands. However, SS also affects many extraglandular systems. In SS patients, the pattern of extraglandular manifestations may have a close similarity with the vasculitic features seen in SLE patients that are mediated by immune complexes and complement. However, SS patients also have an increased frequency of lymphocytic infiltration into extraglandular tissues, as might be expected by their increased frequency of lymphoma in comparison to SLE patients. For example, SS patients need to be evaluated for interstitial nephritis (in contrast to the glomerulonephritis of SLE) or interstitial pneumonitis (in comparison to pleurisy of SLE). This chapter will focus on the clinical extraglandular manifestations of primary SS that are not specifically covered in other chapters. These extraglandular manifestations have led to a recently introduced “disease activity” and “organ damage index.” The recognition of these extraglandular manifestations is important since they have prognostic and therapeutic implications. The differential diagnosis of these extraglandular manifestations includes overlapping features with other autoimmune diseases (particularly systemic lupus erythematosus (SLE), scleroderma, dermatomyositis, celiac sprue, and small- and medium-sized vessel vasculitis), infectious diseases that mimic autoimmune disease (particularly hepatitis C, HIV, syphilis, tuberculosis), and predisposition to drug toxicities that may involve extraglandular organs (particularly skin rashes, nephritis, pneumonitis, myositis, and hematopoietic abnormalities). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124115/ doi: 10.1007/978-1-60327-957-4_17 id: cord-301779-y07xjnpe author: Fox, Sharon E title: Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly across the USA, causing extensive morbidity and mortality, particularly in the African American community. Autopsy can considerably contribute to our understanding of many disease processes and could provide crucial information to guide management of patients with coronavirus disease 2019 (COVID-19). We report on the relevant cardiopulmonary findings in, to our knowledge, the first autopsy series of ten African American decedents, with the cause of death attributed to COVID-19. METHODS: Autopsies were performed on ten African American decedents aged 44–78 years with cause of death attributed to COVID-19, reflective of the dominant demographic of deaths following COVID-19 diagnosis in New Orleans. Autopsies were done with consent of the decedents' next of kin. Pulmonary and cardiac features were examined, with relevant immunostains to characterise the inflammatory response, and RNA labelling and electron microscopy on representative sections. FINDINGS: Important findings include the presence of thrombosis and microangiopathy in the small vessels and capillaries of the lungs, with associated haemorrhage, that significantly contributed to death. Features of diffuse alveolar damage, including hyaline membranes, were present, even in patients who had not been ventilated. Cardiac findings included individual cell necrosis without lymphocytic myocarditis. There was no evidence of secondary pulmonary infection by microorganisms. INTERPRETATION: We identify key pathological states, including thrombotic and microangiopathic pathology in the lungs, that contributed to death in patients with severe COVID-19 and decompensation in this demographic. Management of these patients should include treatment to target these pathological mechanisms. FUNDING: None. url: https://www.sciencedirect.com/science/article/pii/S2213260020302435 doi: 10.1016/s2213-2600(20)30243-5 id: cord-279570-lgbqpfh5 author: Fragkou, Paraskevi C. title: Clinical characteristics and outcomes of measles outbreak in adults: a multicenter retrospective observational study of 93 hospitalized adults in Greece date: 2020-08-26 words: 2743.0 sentences: 166.0 pages: flesch: 48.0 cache: ./cache/cord-279570-lgbqpfh5.txt txt: ./txt/cord-279570-lgbqpfh5.txt summary: In this study we aim to describe the clinical characteristics and complications of measles infection in hospitalized adults during the recent epidemic in Greece. All adult hospitalized patients (≥18 years old) with serologically confirmed and/or clinical features compatible with measles were included. In this study, we describe our experience from the recent outbreak of measles in adult hospitalized patients in Greece [8] . One obese female patient with a Grade II hepatic involvement and pneumonitis that progressed rapidly into acute respiratory distress syndrome (ARDS) requiring mechanical ventilation, died within 6 days of her admission due to high-risk pulmonary embolism (PE) despite being treated with ribavirin. In this study we describe the clinical features and outcomes of mostly healthy and young adult hospitalized patients with measles. In summary, in this study we presented the clinical characteristics of measles infection during the recent epidemic in hospitalized adults in Greece. abstract: OBJECTIVES: Measles outbreaks are increasingly reported among countries that were close-to-eliminate measles infection. There are few reports of clinical characteristics of adult measles in the contemporary literature. In this study we aim to describe the clinical characteristics and complications of measles infection in hospitalized adults during the recent epidemic in Greece. METHODS: A multicentre observational retrospective study was conducted in three tertiary hospitals in Greece. All adult hospitalized patients (≥18 years old) with serologically confirmed and/or clinical features compatible with measles were included. Pediatric patients and patients with missing data were excluded. RESULTS: In total, 93 patients, 40 males (43%) and 53 females (57%), mostly young patients were included. Most of them (87%) had no past medical history. Among women, 4 were pregnant. 56 (60.2%) and 25 (26.9%) patients reported either unknown or incomplete vaccination for measles. Ribavirin was administered in 8 (8.6%) patients. Pneumonitis and hepatic involvement were the most common complications, occurring in 43 (46.2%) and 75 (80.6%) patients respectively. Pneumonitis was significantly associated with male sex, older age, lower lymphocyte counts and higher C-reactive protein (CRP) on admission. One pregnant woman suffered spontaneous fetal miscarriage and one patient died due to acute respiratory distress syndrome (ARDS) and high-risk pulmonary embolism. CONCLUSION: Considerable proportions of incompletely vaccinated or unvaccinated adults have led to the re-emergence of measles in countries with reported close-to-elimination rates. Pneumonitis is a major complication among adults with measles. More studies are imperative in order to explore the role of immune paresis in measles. url: https://www.ncbi.nlm.nih.gov/pubmed/32877891/ doi: 10.1016/j.jcv.2020.104608 id: cord-336782-0zkb39v1 author: Fraile Gutiérrez, V. title: Narrative review of ultrasound in the management of the critically ill patient with SARS-CoV-2 infection (COVID-19): clinical applications in intensive care medicine date: 2020-11-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The clinical picture of SARS-CoV-2 infection (COVID-19) is characterized in its more severe form, by an acute respiratory failure which can worsen to pneumonia and acute respiratory distress syndrome (ARDS), and get complicated with thrombotic events and heart dysfunction. Therefore, admission to the Intensive Care Unit (ICU) is common. Ultrasound, which has become an everyday tool in the ICU, can be very useful during COVID-19 pandemic, since it provides the clinician with information which can be interpreted and integrated within a global assessment during the physical examination. A description of some of the potential applications of ultrasound is depicted in this document, in order to supply the physicians taking care of these patients with a adapted guide to the intensive care setting. Some of its applications since ICU admission include verification of the correct position of the endotracheal tube, contribution to safe cannulation of lines, and identification of complications and thrombotic events. Furthermore, pleural and lung ultrasound can be an alternative diagnostic test to assess the degree of involvement of the lung parenchyma by means of the evaluation of specific ultrasound patterns, identification of pleural effusions and barotrauma. Echocardiography provides information of heart involvement, detects cor pulmonale and shock states. url: https://www.sciencedirect.com/science/article/pii/S2173572720301752 doi: 10.1016/j.medine.2020.10.002 id: cord-316118-ph582weg author: Frajkova, Zofia title: Postintubation Dysphagia During COVID-19 Outbreak-Contemporary Review date: 2020-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 is a global pandemic. Its rapid dissemination and serious course require a novel approach to healthcare practices. Severe disease progression is often associated with the development of the Acute Respiratory Distress Syndrome and may require some form of respiratory support, including endotracheal intubation, mechanical ventilation, and enteral nutrition through a nasogastric tube. These conditions increase the risk of dysphagia, aspiration, and aspiration pneumonia. The data on the incidence and risks of dysphagia associated with COVID-19 are not yet available. However, it is assumed that these patients are at high risk, because of respiratory symptoms and reduced lung function. These findings may exacerbate swallowing deficits. The aim of this review is to summarize available information on possible mechanisms of postintubation dysphagia in COVID-19 patients. Recommendations regarding the diagnosis and management of postintubation dysphagia in COVID-19 patients are described in this contemporary review. url: https://doi.org/10.1007/s00455-020-10139-6 doi: 10.1007/s00455-020-10139-6 id: cord-342808-yonbowkb author: Francque, Sven title: Innovative liver research continues during the current pandemic date: 2020-05-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2589555920300550 doi: 10.1016/j.jhepr.2020.100121 id: cord-314649-1y3ocvz1 author: Franks, Caroline E title: Elevated Cardiac Troponin I Is Associated with Poor Outcomes in COVID-19 Patients at an Academic Medical Center in Midwestern USA date: 2020-06-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/jalm/jfaa092 doi: 10.1093/jalm/jfaa092 id: cord-325700-f102uk2m author: Fraser, Douglas D. title: Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers date: 2020-10-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: Coronavirus disease 2019 continues to spread rapidly with high mortality. We performed metabolomics profiling of critically ill coronavirus disease 2019 patients to understand better the underlying pathologic processes and pathways, and to identify potential diagnostic/prognostic biomarkers. DESIGN: Blood was collected at predetermined ICU days to measure the plasma concentrations of 162 metabolites using both direct injection-liquid chromatography-tandem mass spectrometry and proton nuclear magnetic resonance. SETTING: Tertiary-care ICU and academic laboratory. SUBJECTS: Patients admitted to the ICU suspected of being infected with severe acute respiratory syndrome coronavirus 2, using standardized hospital screening methodologies, had blood samples collected until either testing was confirmed negative on ICU day 3 (coronavirus disease 2019 negative) or until ICU day 10 if the patient tested positive (coronavirus disease 2019 positive). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Age- and sex-matched healthy controls and ICU patients that were either coronavirus disease 2019 positive or coronavirus disease 2019 negative were enrolled. Cohorts were well balanced with the exception that coronavirus disease 2019 positive patients suffered bilateral pneumonia more frequently than coronavirus disease 2019 negative patients. Mortality rate for coronavirus disease 2019 positive ICU patients was 40%. Feature selection identified the top-performing metabolites for identifying coronavirus disease 2019 positive patients from healthy control subjects and was dominated by increased kynurenine and decreased arginine, sarcosine, and lysophosphatidylcholines. Arginine/kynurenine ratio alone provided 100% classification accuracy between coronavirus disease 2019 positive patients and healthy control subjects (p = 0.0002). When comparing the metabolomes between coronavirus disease 2019 positive and coronavirus disease 2019 negative patients, kynurenine was the dominant metabolite and the arginine/kynurenine ratio provided 98% classification accuracy (p = 0.005). Feature selection identified creatinine as the top metabolite for predicting coronavirus disease 2019-associated mortality on both ICU days 1 and 3, and both creatinine and creatinine/arginine ratio accurately predicted coronavirus disease 2019-associated death with 100% accuracy (p = 0.01). CONCLUSIONS: Metabolomics profiling with feature classification easily distinguished both healthy control subjects and coronavirus disease 2019 negative patients from coronavirus disease 2019 positive patients. Arginine/kynurenine ratio accurately identified coronavirus disease 2019 status, whereas creatinine/arginine ratio accurately predicted coronavirus disease 2019-associated death. Administration of tryptophan (kynurenine precursor), arginine, sarcosine, and/or lysophosphatidylcholines may be considered as potential adjunctive therapies. url: https://doi.org/10.1097/cce.0000000000000272 doi: 10.1097/cce.0000000000000272 id: cord-335140-njg0ln33 author: Freeman, Ciara L title: Covid‐19 and Myeloma: what are the implications for now and in the future? date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The pandemic has affected every aspect of myeloma care. Immediate focus is minimizing risk of contracting COVID‐19 and the sequelae of infection. However, what does the future hold for our patients? What lessons will be taken forward to tackle myeloma in the fiscally constrained future? If we embrace the challenges that will emerge in the post‐pandemic environment, the treatment delivered to patients could be more cost effective and better tailored than before. Healthcare delivery post‐COVID will not return to how it was, and now is the time to invest in novel strategies to deliver the best possible outcomes for patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32428242/ doi: 10.1111/bjh.16815 id: cord-349949-jp0hvcg6 author: Freer, Phoebe E. title: The impact of the COVID-19 pandemic on Breast Imaging date: 2020-09-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Starting in Wuhan, China, followed quickly in the United States in January 2020, an outbreak of a novel coronavirus, or COVID-19 escalated to a global pandemic by March(1,2). By September 10, 2020, there were almost 28 million cases worldwide and nearly 6.4 million U.S. cases, with almost 1 million and 200,000 deaths, respectively(3). The outbreak dramatically disrupted global public health as well as precipitated upheaval to the economy and society. With no vaccine or adequate treatment, the most significant weapon to curtail its destruction was a global policy of “social distancing”, advising people to quarantine at home, closing schools and businesses, and disrupting routine health care. As the pandemic lasted, the need to re-open the economy and health care emerged with precautions placed for masking and social distancing. Significant disruptions occurred to breast imaging including deferred screening mammography, triaging diagnostic breast imaging, and changes in breast cancer care algorithms. This article summarizes the effect of the global pandemic – and efforts to curtail its spread – on both breast cancer care and on breast imaging practices including effects on patients, clinical workflow, education and research. url: https://api.elsevier.com/content/article/pii/S0033838920301330 doi: 10.1016/j.rcl.2020.09.008 id: cord-310902-cfci8lef author: Freites Nuñez, Dalifer D title: Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19. METHODS: An observational longitudinal study was conducted during the pandemic peak of severe acute respiratory syndrome coronavirus 2 (1 March 2020 to 24 April). All patients attended at the rheumatology outpatient clinic of a tertiary hospital in Madrid, Spain with a medical diagnosis of AIRD and with symptomatic COVID-19 were included. The main outcome was hospital admission related to COVID-19. The covariates were sociodemographic, clinical and treatments. We ran a multivariable logistic regression model to assess risk factors for the hospital admission. RESULTS: The study population included 123 patients with AIRD and COVID-19. Of these, 54 patients required hospital admission related to COVID-19. The mean age on admission was 69.7 (15.7) years, and the median time from onset of symptoms to hospital admission was 5 (3–10) days. The median length of stay was 9 (6–14) days. A total of 12 patients died (22%) during admission. Compared with outpatients, the factors independently associated with hospital admission were older age (OR: 1.08; p=0.00) and autoimmune systemic condition (vs chronic inflammatory arthritis) (OR: 3.55; p=0.01). No statistically significant findings for exposure to disease-modifying antirheumatic drugs were found in the final model. CONCLUSION: Our results suggest that age and having a systemic autoimmune condition increased the risk of hospital admission, whereas disease-modifying antirheumatic drugs were not associated with hospital admission. url: https://www.ncbi.nlm.nih.gov/pubmed/32769150/ doi: 10.1136/annrheumdis-2020-217984 id: cord-022646-f7qs1obg author: Frey, Noelle V. title: Hematopoietic stem cell transplantation: ASBMT/CIBMTR 2010 tandem meeting highlights and discussion date: 2010-04-27 words: 21917.0 sentences: 1117.0 pages: flesch: 51.0 cache: ./cache/cord-022646-f7qs1obg.txt txt: ./txt/cord-022646-f7qs1obg.txt summary: The authors in this study report the incidence and risk factors associated with the development of solid tumors in 4349 pediatric and adult patients who underwent allogeneic stem cell transplant (SCT) for acute myelogenous leukemia (AML) in CR1 or chronic myelogenous leukemia (CML) in first chronic phase. The lower hOCT1 mRNA expression level in LEU from IMA naïve de novo CML patients compared to healthy volunteers as well as its progressive increase after the start of IMA therapy could be explained by the initial presence and subsequent gradual disappearance of tumor cells from the measured cell population. To confirm this hypothesis, we performed an analysis on the relationship of hOCT1 expression with the percentage of immature myeloid cells in the LEU samples (as a marker of disease burden) obtained from IMA naïve de novo CML patients. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159452/ doi: 10.1002/ajh.21744 id: cord-016280-d47e3art author: Friedberg, Joseph S. title: Pleura: Anatomy, Physiology, and Disorders date: 2008 words: 14487.0 sentences: 746.0 pages: flesch: 44.0 cache: ./cache/cord-016280-d47e3art.txt txt: ./txt/cord-016280-d47e3art.txt summary: In addition to the discomfort, chest tube placement may be accompanied by a number of complications including empyema, lung injury and bleeding, and death." Therefore, coagulation profiles and immunocompetency should be taken into consideration for all patients considered for this procedure . If a large air leak is anticipated or if there is significant effusion associated with the pneumothorax, then a standard 28-French chest tube should be placed. Some of the indications for surgical treatment of a spontaneous pneumothorax include a second pneumothorax (ipsilateral recurrence or a new pneumothorax on the contralateral side); tension physiology; synchronous bilateral pneumothoraces; associated hemothorax (likely secondary to a tom adhesion and complicating approximately 5% of spontaneous pneumothoraces); failure of tube thoracostomy; and lifestyle factors. Chylothorax is an exudative effusion caused by disruption of the lymphatics in the chest, most commonly the thoracic duct, and subsequent drainage of chyle into the pleural space. abstract: Disorders of the pleura and pleural space reflect some of the oldest diseases encountered in surgical history. Hippocrates described the symptoms of empyema 2400 years ago: “Empyema may be recognized by the following symptoms: In the first place the fever is constant, less during the day and greater at night, and copious sweats supervene. There is a desire to cough and the patient expectorates nothing worth mentioning.” He also described an open drainage procedure: “When the fifteenth day after rupture has appeared, prepare a warm bath, set him upon a stool, which is not wobbly, someone should hold his hands, then shake him by the shoulders and listen to see on which side a noise is heard. And right at this place, preferably on the left, make an incision, then it produces death more rarely.”1,2 Beyond providing less-wobbly stools, few advances were made for more than 2000 years that allowed surgeons to routinely enter the pleural cavity, the fear being a potentially fatal pneumothorax. With the advent of positive pressure ventilation in the early 1900s, pneumothorax was no longer a prohibitive risk, and the era of surgical intervention in the pleural cavity had begun.3 url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120517/ doi: 10.1007/978-0-387-68113-9_75 id: cord-290200-csmisulw author: Friedlaender, Alex title: Rethinking the Optimal Duration of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer Throughout the COVID-19 Pandemic date: 2020-05-12 words: 4022.0 sentences: 189.0 pages: flesch: 50.0 cache: ./cache/cord-290200-csmisulw.txt txt: ./txt/cord-290200-csmisulw.txt summary: Immune checkpoint inhibitors (ICPIs) have revolutionized the management and prognosis of fit patients with advanced non-small cell lung cancer (NSCLC). In the OAK trial, assessing the efficacy of the anti-PD-L1 antibody, atezolizumab, until progression or unacceptable toxicity in previously treated advanced NSCLC, regardless of PD-L1 expression, patients, 28% of those in the experimental arm demonstrated long-term survival, defined as greater or equal to 24 months (10). In the Checkmate 153 trial, continuous nivolumab treatment resulted in grade 3 or higher immune-related adverse events in 8% of patients, compared to 4% in the 1-year fixed duration cohort, but very few new safety events took place after the first year of therapy (8) . CheckMate 153: randomized results of continuous vs 1-year fixed-duration nivolumab in patients with advanced non-small-cell lung cancer Early immune-related adverse events and association with outcome in advanced non-small cell lung cancer patients treated with nivolumab: a prospective cohort study abstract: Immune checkpoint inhibitors (ICPIs) have revolutionized the management and prognosis of fit patients with advanced non-small cell lung cancer (NSCLC). Recently, the publication of 5-year survival rates has cemented the role of ICPIs in NSCLC. An ongoing challenge is to determine the optimal treatment duration to find the balance between efficacy, toxicity and cost. From the onset of ICPI trials, different durations were used, ranging from treatment until progression or toxicity, to fixed durations of 2 years. Subsequently, exploratory analyses from a 1-year fixed duration trial failed to change practice. There are, to date, no adequately powered prospective trials addressing this important question. With today's severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pandemic, more than ever, the question resurfaces with added factors tilting the already shaky therapeutic balance. Here, we will discuss current data regarding ICPI treatment duration and incorporate this into the context of the ongoing pandemic. We conclude with a discussion of pragmatic approaches, should physicians be unable to continue standard therapy. url: https://www.ncbi.nlm.nih.gov/pubmed/32574277/ doi: 10.3389/fonc.2020.00862 id: cord-340811-w4x4falm author: Frizzelli, Annalisa title: What happens to people’s lungs when they get coronavirus disease 2019? date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus SARS-CoV-2 was first identified in Wuhan in December 2019 as cause of the consequent novel coronavirus disease 2019 (COVID-19). The virus has since spread worldwide. The clinical presentation following human infection ranges from a mild upper respiratory tract infection to severe acute respiratory distress syndrome and sepsis. We reviewed literature using Pubmed to identify relevant English-language articles published until April 15, 2020. Search terms include novel coronavirus pneumonia, severe acute respiratory syndrome coronavirus 2, coronavirus and ventilation. We summarized what SARS-CoV-2 infection means for the lungs. (www.actabiomedica.it) url: https://www.ncbi.nlm.nih.gov/pubmed/32420938/ doi: 10.23750/abm.v91i2.9574 id: cord-298787-4vo9gpiu author: Frost, Holly M. title: Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1–3 date: 2013-10-16 words: 3897.0 sentences: 238.0 pages: flesch: 51.0 cache: ./cache/cord-298787-4vo9gpiu.txt txt: ./txt/cord-298787-4vo9gpiu.txt summary: A retrospective chart review and comparison of patients positive for HPIV types 1–4 by multiplex polymerase chain reaction between 2009 and 2012 at Children''s Hospital Colorado was performed. Human parainfluenza viruses (HPIVs) are among the most common causes of acute respiratory tract infections in children [1] [2] [3] [4] [5] [6] . However, these studies have primarily been conducted outside North America and are limited by small sample sizes and often included patients with concurrent respiratory viral infections, making it difficult to assess the true clinical significance or epidemiology of HPIV-4 in pediatric patients. Previous studies have implicated HPIV-4 as a cause of upper and lower respiratory tract infections in children, but have not definitively demonstrated its epidemiology secondary to limited sample sizes [12, 18] . The study was performed at a large tertiary care children''s hospital, most likely selecting the more seriously ill patients with HPIV infections. abstract: Background. Human parainfluenza viruses (HPIVs) are among the most common causes of respiratory tract infections in children. Little is known about the epidemiology and clinical presentation of HPIV type 4. Methods. A retrospective chart review and comparison of patients positive for HPIV types 1–4 by multiplex polymerase chain reaction between 2009 and 2012 at Children's Hospital Colorado was performed. Patients who had only direct fluorescent antibody testing performed or concurrent viral infections were excluded. Results. Of 11 533 samples, 752 (6.5%) were positive for HPIV. After exclusion criteria, 316 samples were included in the study. HPIV-4 had year-round prevalence with biennial peaks in odd-numbered years. HPIV-4 and HPIV-3 had similar clinical presentations. 50.8% and 51.5% of patients with HPIV-3–4 had hypoxia compared to 20.3% and 33.3% of patients with HPIV-1–2 (P < .01). HPIV-1 (23.6%) and HPIV-2 (24.2%) were more associated with stridor than HPIV-3 (6.6%) and HPIV-4 (0%) (P < .01). No patients with HPIV-4 had croup. Patients with HPIV-4 had similar lengths of stay and mortality as those with HPIV-1–3. Conclusions. This is the first large-scale analysis of HPIV-4 clinical and epidemiologic features. HPIV-4 was most similar to HPIV-3 in clinical presentation. HPIV-4 had year-round prevalence with peaks in the autumn of odd-numbered years. HPIV-4 is a common respiratory pathogen capable of causing significant morbidity in children. url: https://academic.oup.com/jid/article-pdf/209/5/695/13804474/jit552.pdf doi: 10.1093/infdis/jit552 id: cord-320445-pdvkyzci author: Fry, Alicia M. title: Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand date: 2007-04-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. We detected human bocavirus (HBoV) infection in 4.5% of hospitalized patients with pneumonia in rural Thailand. However, the role of HBoV as a pathogen is unclear. Methods. We compared HBoV infection in patients with pneumonia with that in asymptomatic control patients enrolled between 1 September 2004 and 31 August 2005 in the same hospitals in Thailand.We examined outpatients with influenza-like illness for HBoV infection and tested for 13 additional respiratory viruses. Epidemiologic and clinical characteristics of HBoV infection are described. Results. HBoV infection was detected in 20 (3.9%) of 512 outpatients and 3 (1%) of 280 control patients. Coinfection with other viruses was detected in 83% of patients with pneumonia and in 90% of outpatients. Compared with control patients, HBoV infection was significantly associated with pneumonia requiring hospitalization (adjusted odds ratio, 3.56 [95% confidence interval, 1.06–11.91]; P = .04). Eighty-three percent of HBoV infections were detected in patients with pneumonia who were <5 years old. More patients with pneumonia associated with HBoV—respiratory syncytial virus (RSV) or human parainfluenza virus (HPIV) coinfections had wheezing than patients with RSV and HPIV infections alone (9 [53%] of 17 vs. 32 [23%] of 138]; P = .01). Conclusions. HBoV infection was epidemiologically associated with pneumonia among young children in rural Thailand, but infection and illness may be dependent on coinfection with other viruses. url: https://www.ncbi.nlm.nih.gov/pubmed/17330795/ doi: 10.1086/512163 id: cord-270723-cjfglili author: Fteiha, Bashar title: QTc prolongation among hydroxychloroquine sulfate‐treated COVID‐19 patients: An observational study date: 2020-10-15 words: 3317.0 sentences: 191.0 pages: flesch: 50.0 cache: ./cache/cord-270723-cjfglili.txt txt: ./txt/cord-270723-cjfglili.txt summary: Age > 65 years, congestive heart failure, severity of disease, C‐reactive protein level, hypokalemia and furosemide treatment, were all associated with QTc prolongation. CONCLUSION: In patients treated with HCQ, QTc prolongation was associated with the presence of traditional risk factors such as hypokalemia and furosemide treatment. All rights reserved Univariate analysis revealed that in COVID-19 patients treated with HCQ, age above 65 years, severe or critical illness, congestive heart failure, hypokalemia, furosemide treatment and increased CRP level were all significantly associated with the composite endpoint (Table 2) . However, multivariate analysis in this small dataset also suggested that in COVID-19 patients treated with HCQ, concomitant hypokalemia and furosemide treatment were strongly associated with QTc prolongation. In conclusion, our study shows that QTc prolongation among HCQ-treated patients was associated with traditional, modifiable risk factors such as hypokalemia and furosemide treatment which are both commonly observed in COVID-19 patients. abstract: BACKGROUND: The liberal administration of hydroxychloroquine‐sulphate (HCQ) to COVID‐19 patients has raised concern regarding the risk of QTc prolongation and cardiac arrhythmias, particularly when prescribed with azithromycin. We evaluated the incidence of QTc prolongation among moderately and severely ill COVID‐19 patients treated with HCQ and of the existence of concomitant alternative causes. METHODS: All COVID‐19 patients treated with HCQ (between Mar 1 and Apr 14, 2020) in a tertiary medical center were included. Clinical characteristics and relevant risk factors were collected from the electronic medical records. Individual patient QTc intervals were determined before and after treatment with HCQ. The primary outcome measure sought was a composite endpoint comprised of either an increase ≥ 60 milliseconds (ms) in the QTc interval compared with pretreatment QTc, and/or a maximal QTc interval >500 ms. RESULTS: Ninety patients were included. Median age was 65 years (IQR 55‐75) and 57 (63%) were male. Thirty‐nine patients (43%) were severely or critically ill. Hypertension and obesity were common (n=23 each, 26%). QTc prolongation evolved in fourteen patients (16%). Age > 65 years, congestive heart failure, severity of disease, C‐reactive protein level, hypokalemia and furosemide treatment, were all associated with QTc prolongation. Adjusted analysis showed that QTc prolongation was five times more likely with hypokalemia [OR 5, (95% CI, 1.3‐20)], and three times more likely with furosemide treatment [ OR 3 (95% CI, 1.01‐13.7)]. CONCLUSION: In patients treated with HCQ, QTc prolongation was associated with the presence of traditional risk factors such as hypokalemia and furosemide treatment. url: https://www.ncbi.nlm.nih.gov/pubmed/33063447/ doi: 10.1111/ijcp.13767 id: cord-011221-rhyxp4v5 author: Fu, Chih-Yuan title: Obesity is Associated with Worse Outcomes Among Abdominal Trauma Patients Undergoing Laparotomy: A Propensity-Matched Nationwide Cohort Study date: 2019-11-11 words: 2497.0 sentences: 153.0 pages: flesch: 47.0 cache: ./cache/cord-011221-rhyxp4v5.txt txt: ./txt/cord-011221-rhyxp4v5.txt summary: title: Obesity is Associated with Worse Outcomes Among Abdominal Trauma Patients Undergoing Laparotomy: A Propensity-Matched Nationwide Cohort Study Patients who received laparotomies were analyzed using propensity score matching (PSM) to evaluate the mortality rate and LOS between obese and non-obese patients. In this study, a nationwide analysis was performed using the NTDB to evaluate the role of obesity in abdominal trauma patients who required laparotomies. However, there was no significant difference in mortality rate, hospital LOS, or ICU LOS between the SBP systolic blood pressure, ED emergency department, RR respiratory rate, GCS Glasgow coma scale, ISS injury severity score, BMI body mass index, CI confidence interval obese and non-obese in patients who did not receive laparotomy after matching (Table 3 ). Obesity is associated with increased mortality and LOS in abdominal trauma patients who received laparotomies versus those who did not. abstract: INTRODUCTION: Obesity is associated with increased morbidity and mortality in abdominal trauma patients. The characteristics of abdominal trauma patients with poor outcomes related to obesity require evaluation. We hypothesize that obesity is related to increased mortality and length of stay (LOS) among abdominal trauma patients undergoing laparotomies. METHODS: Abdominal trauma patients were identified from the National Trauma Data Bank between 2013 and 2015. Patients who received laparotomies were analyzed using propensity score matching (PSM) to evaluate the mortality rate and LOS between obese and non-obese patients. Patients without laparotomies were analyzed as a control group using PSM cohort analysis. RESULTS: A total of 33,798 abdominal trauma patients were evaluated, 10,987 of them received laparotomies. Of these patients, the proportion of obesity in deceased patients was significantly higher when compared to the survivors (33.1% vs. 26.2%, p < 0.001). Elevation of one kg/m(2) of body mass index independently resulted in 2.5% increased odds of mortality. After a well-balanced PSM, obese patients undergoing laparotomies had significantly higher mortality rates [3.7% vs. 2.4%, standardized difference (SD) = 0.241], longer hospital LOS (11.1 vs. 9.6 days, SD = 0.135), and longer intensive care unit LOS (3.5 vs. 2.3 days, SD = 0.171) than non-obese patients undergoing laparotomies. CONCLUSIONS: Obesity is associated with increased mortality in abdominal trauma patients who received laparotomies versus those who did not. Obesity requires a careful evaluation of alternatives to laparotomy in injured patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00268-019-05268-5) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223826/ doi: 10.1007/s00268-019-05268-5 id: cord-265098-u5qssib9 author: Fu, Xin-yan title: Effect of COVID-19 outbreak on the treatment time of patients with acute ST-segment elevation myocardial infarction date: 2020-09-17 words: 1355.0 sentences: 80.0 pages: flesch: 55.0 cache: ./cache/cord-265098-u5qssib9.txt txt: ./txt/cord-265098-u5qssib9.txt summary: title: Effect of COVID-19 outbreak on the treatment time of patients with acute ST-segment elevation myocardial infarction OBJECTIVE: To explore the effect of COVID-19 outbreak on the treatment time of patients with ST-segment elevation myocardial infarction (STEMI) in Hangzhou, China. METHODS: We retrospectively reviewed the data of STEMI patients admitted to the Hangzhou Chest Pain Center (CPC) during a COVID-19 epidemic period in 2020 (24 cases) and the same period in 2019 (29 cases). Cumulative mortality was showed in Kaplan-Meier survival curves after the surgery in the 2020 group was significantly different higher than the 2019 group during the 28 days.The diagnosis and treatment process of STEMI patients during an epidemic should be optimized to improve their prognosis. Suggestions on management strategies for ST-segment elevation acute myocardial infarction (STEMI) combined with novel coronavirus infection Impact of symptom onset to first medical contact time on the prognosis of patients with acute ST-segment elevation myocardial infarction abstract: OBJECTIVE: To explore the effect of COVID-19 outbreak on the treatment time of patients with ST-segment elevation myocardial infarction (STEMI) in Hangzhou, China. METHODS: We retrospectively reviewed the data of STEMI patients admitted to the Hangzhou Chest Pain Center (CPC) during a COVID-19 epidemic period in 2020 (24 cases) and the same period in 2019 (29 cases). General characteristics of the patients were recorded, analyzed, and compared. Moreover, we compared the groups for the time from symptom onset to the first medical contact (SO-to-FMC), time from first medical contact to balloon expansion (FMC-to-B), time from hospital door entry to first balloon expansion (D-to-B), and catheter room activation time. The groups were also compared for postoperative cardiac color Doppler ultrasonographic left ventricular ejection fraction (LVEF),the incidence of major adverse cardiovascular and cerebrovascular events (MACCE),Kaplan-Meier survival curves during the 28 days after the operation. RESULTS: The times of SO-to-FMC, D-to-B, and catheter room activation in the 2020 group were significantly longer than those in the 2019 group (P < 0.05). The cumulative mortality after the surgery in the 2020 group was significantly higher than the 2019 group (P < 0.05). CONCLUSION: The pre-hospital and in-hospital treatment times of STEMI patients during the COVID-19 epidemic were longer than those before the epidemic. Cumulative mortality was showed in Kaplan-Meier survival curves after the surgery in the 2020 group was significantly different higher than the 2019 group during the 28 days.The diagnosis and treatment process of STEMI patients during an epidemic should be optimized to improve their prognosis. url: https://www.ncbi.nlm.nih.gov/pubmed/33039221/ doi: 10.1016/j.ajem.2020.09.038 id: cord-301805-sb0ij8k7 author: Fuentes, Blanca title: Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study date: 2020-11-04 words: 3834.0 sentences: 235.0 pages: flesch: 44.0 cache: ./cache/cord-301805-sb0ij8k7.txt txt: ./txt/cord-301805-sb0ij8k7.txt summary: METHODS: This translational study consists of two studies conducted in parallel: The first study is an observational, multicenter, prospective clinical study in which 340 patients with acute IS will be subcutaneously implanted a sensor to continuously monitor blood glucose levels for 96 h. DISCUSSION: The GLIAS-III study will be the first translational approach analyzing the prognostic influence of GV, evaluated by the use of subcutaneous glucose monitors, in acute stroke. We hypothesized that GV, assessable by means of continuous subcutaneous monitoring devices, could act as a powerful prognostic predictor of mortality, possibly higher than assessment of mean or maximum blood glucose levels and that the different treatment regimens used in routine clinical practice could modify glycemic variability. No laboratory data other than HbA1c will be collected for Discussion: The GLIAS-III study will be the first translational approach analyzing the prognostic influence of GV, evaluated by the use of subcutaneous glucose monitors, in acute stroke. abstract: INTRODUCTION: Glycemic variability (GV) represents the amplitude of oscillations in glucose levels over time and is associated with higher mortality in critically ill patients. Our aim is to evaluate the impact of GV on acute ischemic stroke (IS) outcomes in humans and explore the impact of two different insulin administration routes on GV in an animal model. METHODS: This translational study consists of two studies conducted in parallel: The first study is an observational, multicenter, prospective clinical study in which 340 patients with acute IS will be subcutaneously implanted a sensor to continuously monitor blood glucose levels for 96 h. The second study is a basic experimental study using an animal model (rats) with permanent occlusion of the middle cerebral artery and induced hyperglycemia (through an intraperitoneal injection of nicotinamide and streptozotocin). The animal study will include the following 6 groups (10 animals per group): sham; hyperglycemia without IS; IS without hyperglycemia; IS and hyperglycemia without treatment; IS and hyperglycemia and intravenous insulin; and IS and hyperglycemia and subcutaneous insulin. The endpoint for the first study is mortality at 3 months, while the endpoints for the animal model study are GV, functional recovery and biomarkers. DISCUSSION: The GLIAS-III study will be the first translational approach analyzing the prognostic influence of GV, evaluated by the use of subcutaneous glucose monitors, in acute stroke. Trial registration https://www.clinicaltrials.gov (NCT04001049) url: https://www.ncbi.nlm.nih.gov/pubmed/33148277/ doi: 10.1186/s12967-020-02586-4 id: cord-001493-3yu2di1g author: Fujishima, Seitaro title: Pathophysiology and biomarkers of acute respiratory distress syndrome date: 2014-05-07 words: 3096.0 sentences: 159.0 pages: flesch: 36.0 cache: ./cache/cord-001493-3yu2di1g.txt txt: ./txt/cord-001493-3yu2di1g.txt summary: Acute respiratory distress syndrome (ARDS) is defined as an acute-onset, progressive, hypoxic condition with radiographic bilateral lung infiltration, which develops after several diseases or injuries, and is not derived from hydrostatic pulmonary edema. In parallel with progress in understanding the pathophysiology of ARDS, various humoral factors induced by inflammation and molecules derived from activated cells or injured tissues have been shown as potential biomarkers that may be applied in clinical practice. Numerous proinflammatory cytokines play major roles in acute inflammation and the development of inflammatory lung diseases, including ARDS. Increased levels of soluble receptor for advanced glycation end products (sRAGE) and high mobility group box 1 (HMGB1) are associated with death in patients with acute respiratory distress syndrome Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients Acute Respiratory Distress Syndrome Network: Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury abstract: Acute respiratory distress syndrome (ARDS) is defined as an acute-onset, progressive, hypoxic condition with radiographic bilateral lung infiltration, which develops after several diseases or injuries, and is not derived from hydrostatic pulmonary edema. One specific pathological finding of ARDS is diffuse alveolar damage. In 2012, in an effort to increase diagnostic specificity, a revised definition of ARDS was published in JAMA. However, no new parameters or biomarkers were adopted by the revised definition. Discriminating between ARDS and other similar diseases is critically important; however, only a few biomarkers are currently available for diagnostic purposes. Furthermore, predicting the severity, response to therapy, or outcome of the illness is also important for developing treatment strategies for each patient. However, the PaO(2)/FIO(2) ratio is currently the sole clinical parameter used for this purpose. In parallel with progress in understanding the pathophysiology of ARDS, various humoral factors induced by inflammation and molecules derived from activated cells or injured tissues have been shown as potential biomarkers that may be applied in clinical practice. In this review, the current understanding of the basic pathophysiology of ARDS and associated candidate biomarkers will be discussed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267590/ doi: 10.1186/2052-0492-2-32 id: cord-320477-zbp8a8dr author: Fung, Timothy H.M. title: Addressing COVID‐19 fear to improve clinic attendance for patients with wet age‐related macular degeneration date: 2020-06-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1111/aos.14520 doi: 10.1111/aos.14520 id: cord-253295-82ydczid author: Funkhouser, William K. title: Pathology: the clinical description of human disease date: 2020-07-24 words: 8864.0 sentences: 396.0 pages: flesch: 34.0 cache: ./cache/cord-253295-82ydczid.txt txt: ./txt/cord-253295-82ydczid.txt summary: Patient workup uses present illness history with reference to past medical history, review of other organ systems for other abnormalities, review of family history, physical examination, radiographic studies, clinical laboratory studies (for example, peripheral blood or CSF specimens), and anatomic pathology laboratory studies (for example, tissue biopsy or pleural fluid cytology specimens). Obviously, arrival at the correct diagnosis is a function of the examining physician and pathologist (fund of knowledge, experience, alertness), the prevalence of the disease in question in the particular patient (age, race, sex, site), and the sensitivity/ specificity of the screening tests used (physical exam, vital signs, blood solutes, tissue stains, genetic assays). However, understanding the molecular and cellular pathogenesis of a disease allows development of screening methods to determine risk for clinically unaffected individuals, as well as mechanistic approaches to specific therapy. abstract: Pathology is that field of science and medicine concerned with the study of diseases, specifically their initial causes (etiologies), their step-wise progressions (pathogenesis), and their effects on normal structure and function. This chapter will consider the history of relevant discoveries and technologies that have led to our current understanding of diseases, as well as the Pathologist’s current role in the diagnosis, prognosis, and prediction of response of human diseases. url: https://api.elsevier.com/content/article/pii/B9780128132579000115 doi: 10.1016/b978-0-12-813257-9.00011-5 id: cord-269835-mz7i66qp author: Furfaro, Federica title: SFED recommendations for IBD endoscopy during COVID-19 pandemic: Italian and French experience date: 2020-06-11 words: 7275.0 sentences: 295.0 pages: flesch: 38.0 cache: ./cache/cord-269835-mz7i66qp.txt txt: ./txt/cord-269835-mz7i66qp.txt summary: The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has required a complete change in the management of patients with inflammatory bowel disease (IBD) who need to undergo endoscopic procedures. In particular, recommendations regarding the use of personal protective equipment to prevent COVID-19 transmission, both for patients and health-care professionals, are proposed and different scenarios in endoscopic IBD management are evaluated to suggest when endoscopy could be rescheduled and replaced by alternative biomarkers. The panel of experts con sidered possible aerosolization during colonoscopy, in particular during the insertion and removal of instruments through the biopsy channel and the presence of the virus in the stool and advised on the use of N95 masks for lower gastrointestinal procedures as a precautionary measure to protect the endoscopist from the risk of possible COVID-19 transmission from the patient if infected by SARS-CoV-2 (ref. abstract: The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has required a complete change in the management of patients with inflammatory bowel disease (IBD) who need to undergo endoscopic procedures. Several preventive measures must be taken to avoid the spread of infection among health-care professionals and patients with IBD, including the use of personal protective equipment, greater attention to endoscopic room hygiene and rescheduling of non-urgent procedures. This Perspective aims to provide a guide based on the Italian and French experience to better face the difficulties encountered by endoscopists during this global health emergency. In particular, recommendations regarding the use of personal protective equipment to prevent COVID-19 transmission, both for patients and health-care professionals, are proposed and different scenarios in endoscopic IBD management are evaluated to suggest when endoscopy could be rescheduled and replaced by alternative biomarkers. url: https://www.ncbi.nlm.nih.gov/pubmed/32528139/ doi: 10.1038/s41575-020-0319-3 id: cord-356349-ey5vnddu author: Fusco, Francesco M title: Infection control management of patients with suspected highly infectious diseases in emergency departments: data from a survey in 41 facilities in 14 European countries date: 2012-01-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: In Emergency and Medical Admission Departments (EDs and MADs), prompt recognition and appropriate infection control management of patients with Highly Infectious Diseases (HIDs, e.g. Viral Hemorrhagic Fevers and SARS) are fundamental for avoiding nosocomial outbreaks. METHODS: The EuroNHID (European Network for Highly Infectious Diseases) project collected data from 41 EDs and MADs in 14 European countries, located in the same facility as a national/regional referral centre for HIDs, using specifically developed checklists, during on-site visits from February to November 2009. RESULTS: Isolation rooms were available in 34 facilities (82,9%): these rooms had anteroom in 19, dedicated entrance in 15, negative pressure in 17, and HEPA filtration of exhausting air in 12. Only 6 centres (14,6%) had isolation rooms with all characteristics. Personnel trained for the recognition of HIDs was available in 24 facilities; management protocols for HIDs were available in 35. CONCLUSIONS: Preparedness level for the safe and appropriate management of HIDs is partially adequate in the surveyed EDs and MADs. url: https://doi.org/10.1186/1471-2334-12-27 doi: 10.1186/1471-2334-12-27 id: cord-027677-fc410vto author: GOULD, JANE M. title: Pharyngitis, Stomatitis, Peritonsillar, and Retropharyngeal Abscess date: 2020-06-22 words: 6196.0 sentences: 365.0 pages: flesch: 47.0 cache: ./cache/cord-027677-fc410vto.txt txt: ./txt/cord-027677-fc410vto.txt summary: Acute retroviral syndrome, a manifestation of acute HIV infection, typically has an incubation period that ranges from 3 to 5 weeks with symptoms that include fever, nonexudative pharyngitis, lymphadenopathy, arthralgia, myalgia, and lethargy. haemolyticum pharyngitis include peritonsillar abscess (PTA) similar to that of GA␤HS infection (see later). Periodic fever associated with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) typically occurs in patients younger than 5 years of age. GA␤HS requires antimicrobial therapy in order to prevent the development of acute rheumatic fever (ARF) and to reduce the risk of suppurative complications such as PTA, retropharyngeal abscess, cervical adenitis, sinusitis, mastoiditis, otitis media, and bacteremia leading to metastatic infection. It usually occurs in older school-age children, adolescents, and young adults as a complication of recurrent bacterial tonsillitis or a secondary bacterial infection following viral pharyngitis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310945/ doi: 10.1016/b978-0-323-02041-1.50017-1 id: cord-264122-n64tm6qr author: Gaballa, Salem title: COVID-19 Fears May Be Worse Than the Virus: A Case of Cardiogenic Shock Secondary to Post-Myocardial Infarction Ventricular Septum Rupture date: 2020-06-24 words: 2326.0 sentences: 133.0 pages: flesch: 47.0 cache: ./cache/cord-264122-n64tm6qr.txt txt: ./txt/cord-264122-n64tm6qr.txt summary: title: COVID-19 Fears May Be Worse Than the Virus: A Case of Cardiogenic Shock Secondary to Post-Myocardial Infarction Ventricular Septum Rupture We report a sad and unfortunate case of an 87-year-old female who was experiencing pressure-like chest pain but presented to the emergency room five days later out of fear of catching COVID-19 from the hospital. Ventricular septal rupture (VSR) is an uncommon but fatal mechanical complication of myocardial infarction (MI). Ventricular septal rupture following acute myocardial infarction Post-infarction ventricular septal defect: risk factors and early outcomes Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction: a report from the SHOCK Trial Registry Ventricular septal rupture after acute myocardial infarction Surgical repair of ventricular septal defect after myocardial infarction: outcomes from the Society of Thoracic Surgeons National Database abstract: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been a growing and justifiable fear of catching the virus from the emergency rooms, thus decreasing the hospital visits. With Virginia State slowly reopening and HCA local hospitals resuming elective procedures, the number of emergency room visits, are recovering and increasing. We report a sad and unfortunate case of an 87-year-old female who was experiencing pressure-like chest pain but presented to the emergency room five days later out of fear of catching COVID-19 from the hospital. On presentation to the ED, she was found to have an non-ST-elevation myocardial infarction, which required urgent stenting of the left anterior descending artery. Unfortunately, several hours later, she developed fatal cardiogenic shock due to ventricular septal rupture. We are reporting this case to highlight one of the many potential bad outcomes as a result of a delay in seeking necessary medical attention due to the fear of contracting the virus. url: https://doi.org/10.7759/cureus.8809 doi: 10.7759/cureus.8809 id: cord-338602-6n309bnp author: Gadotti, Ana Carolina title: IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection date: 2020-09-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Innate and adaptive immune responses have been evaluated in infected patients with COVID-19. The severity of the disease has been supposed to be associated with some profile not reported with other bacterial and viral pneumonia. We proposed a study in patients with moderate to severe COVID-19 infection to evaluate the interleukin patterns and its role as prognosis factors. METHODS: A prospective cohort with moderate and severe cases of COVID-19 infection from June to July 2020. Blood samples from patients were collected regularly to evaluate IFN-γ, TNF-α, IL-4, IL-6, and IL-10. Clinical, laboratory, radiological data, and outcomes were recorded. The outcome variable was in-hospital death, survival, mechanical ventilation, and admission at the intensive care unit. Data are presented in median and interquartile range [IQR]. RESULTS: We evaluated the Th1 and Th2 responses according to evolution, distinguishing possible predictive markers. The IFN-γ median of 323 pg/mL [IQR 166-570] was found in patients who died and 208 pg/mL [IQR 155-392] in the survival group (p = 0.017). IFN-γ was also higher in the early stages of the disease (394 pg/mL [IQR 229-575] against 162 pg/mL [IQR 117-259], p < 0.001). IL-4 that was increased in late-stage (182 pg/mL [IQR 162-199] against 131 pg/mL [IQR 124-152], p < 0.001) but not associated with mortality. Also, death was also related to male gender (relative risk = 1.5 [95% confidence interval = 1.1-2.0]). CONCLUSION: Our results suggest that the activation of the host immune response between Th1 or Th2 in COVID-19 infection may be related to the final result between discharge or death. This implies an attempt to control cytokines, such as IFN-γ, with combined therapies for clinical treatment. url: https://www.sciencedirect.com/science/article/pii/S0168170220310789?v=s5 doi: 10.1016/j.virusres.2020.198171 id: cord-322448-s04e6po9 author: Gadsby, Naomi J. title: Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia date: 2016-04-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. The frequent lack of a microbiological diagnosis in community-acquired pneumonia (CAP) impairs pathogen-directed antimicrobial therapy. This study assessed the use of comprehensive multibacterial, multiviral molecular testing, including quantification, in adults hospitalized with CAP. Methods. Clinical and laboratory data were collected for 323 adults with radiologically-confirmed CAP admitted to 2 UK tertiary care hospitals. Sputum (96%) or endotracheal aspirate (4%) specimens were cultured as per routine practice and also tested with fast multiplex real-time polymerase-chain reaction (PCR) assays for 26 respiratory bacteria and viruses. Bacterial loads were also calculated for 8 bacterial pathogens. Appropriate pathogen-directed therapy was retrospectively assessed using national guidelines adapted for local antimicrobial susceptibility patterns. Results. Comprehensive molecular testing of single lower respiratory tract (LRT) specimens achieved pathogen detection in 87% of CAP patients compared with 39% with culture-based methods. Haemophilus influenzae and Streptococcus pneumoniae were the main agents detected, along with a wide variety of typical and atypical pathogens. Viruses were present in 30% of cases; 82% of these were codetections with bacteria. Most (85%) patients had received antimicrobials in the 72 hours before admission. Of these, 78% had a bacterial pathogen detected by PCR but only 32% were culture-positive (P < .0001). Molecular testing had the potential to enable de-escalation in number and/or spectrum of antimicrobials in 77% of patients. Conclusions. Comprehensive molecular testing significantly improves pathogen detection in CAP, particularly in antimicrobial-exposed patients, and requires only a single LRT specimen. It also has the potential to enable early de-escalation from broad-spectrum empirical antimicrobials to pathogen-directed therapy. url: https://www.ncbi.nlm.nih.gov/pubmed/26747825/ doi: 10.1093/cid/civ1214 id: cord-353594-z1vxamvp author: Gagiannis, Daniel title: Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD) date: 2020-10-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND AND OBJECTIVES: Understanding the pathophysiology of respiratory failure in coronavirus disease 2019 (COVID-19) is indispensable for development of therapeutic strategies. Since we observed similarities between COVID-19 and interstitial lung disease in connective tissue disease (CTD-ILD), we investigated features of autoimmunity in SARS-CoV-2-associated respiratory failure. METHODS: We prospectively enrolled 22 patients with RT-PCR-confirmed SARS-CoV-2 infection and 10 patients with non-COVID-19-associated pneumonia. Full laboratory testing was performed including autoantibody (AAB; ANA/ENA) screening using indirect immunofluorescence and immunoblot. Fifteen COVID-19 patients underwent high-resolution computed tomography. Transbronchial biopsies/autopsy tissue samples for histopathology and ultrastructural analyses were obtained from 4/3 cases, respectively. RESULTS: Thirteen (59.1%) patients developed acute respiratory distress syndrome (ARDS), and five patients (22.7%) died from the disease. ANA titers ≥1:320 and/or positive ENA immunoblots were detected in 11/13 (84.6%) COVID-19 patients with ARDS, in 1/9 (11.1%) COVID-19 patients without ARDS (p = 0.002) and in 4/10 (40%) patients with non-COVID-19-associated pneumonias (p = 0.039). Detection of AABs was significantly associated with a need for intensive care treatment (83.3 vs. 10%; p = 0.002) and occurrence of severe complications (75 vs. 20%, p = 0.03). Radiological and histopathological findings were highly heterogeneous including patterns reminiscent of exacerbating CTD-ILD, while ultrastructural analyses revealed interstitial thickening, fibroblast activation, and deposition of collagen fibrils. CONCLUSIONS: We are the first to report overlapping clinical, serological, and imaging features between severe COVID-19 and acute exacerbation of CTD-ILD. Our findings indicate that autoimmune mechanisms determine both clinical course and long-term sequelae after SARS-CoV-2 infection, and the presence of autoantibodies might predict adverse clinical course in COVID-19 patients. url: https://doi.org/10.3389/fimmu.2020.587517 doi: 10.3389/fimmu.2020.587517 id: cord-325316-uffxyas1 author: Gagliano, Annalisa title: COVID-19 Epidemic in the Middle Province of Northern Italy: Impact, Logistics, and Strategy in the First Line Hospital date: 2020-03-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus (COVID-19) began in China in early December 2019 and rapidly has spread to many countries around the globe, with the number of confirmed cases increasing every day. An epidemic has been recorded since February 20 in a middle province in Northern Italy (Lodi province, in the low Po Valley). The first line hospital had to redesign its logistical and departmental structure to respond to the influx of COVID-19-positive patients who needed hospitalization. Logistical and structural strategies were guided by the crisis unit, managing in 8 days from the beginning of the epidemic to prepare the hospital to be ready to welcome more than 200 COVID-19-positive patients with different ventilatory requirements, keeping clean emergency access lines, and restoring surgical interventions and deferred urgent, routine activity. url: https://www.ncbi.nlm.nih.gov/pubmed/32207676/ doi: 10.1017/dmp.2020.51 id: cord-300963-1n1f8mf2 author: Gajendran, Mahesh title: Inflammatory bowel disease amid the COVID-19 pandemic: impact, management strategies, and lessons learned date: 2020-10-12 words: 6681.0 sentences: 350.0 pages: flesch: 46.0 cache: ./cache/cord-300963-1n1f8mf2.txt txt: ./txt/cord-300963-1n1f8mf2.txt summary: Previous studies based on SARS-CoV-1 showed that the "cytokine storm" was strongly associated with viral sepsis, inflammation-induced lung injury, and acute respiratory distress syndrome (ARDS) [32, 34] . With regard to IBD-specific risk factors, it is speculated that patients on immunosuppressive agents, those with active IBD symptoms, malnutrition, and frequent visits to clinics or hospitals are at greater risk of acquiring SARS-CoV-2 infection [50] . The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) maintains a registry for reporting COVID-19 in IBD patients called SECURE-IBD registry. Hence, all the societies have recommended that patients continue their IBD medications to sustain remission, because the risk of disease flare-up outweighs the chance of contracting SARS-CoV-2 infection. The management strategy will depend on multiple factors, such as the patient''s age, the severity of the COVID-19 infection, the clinical status of the IBD, and the presence of other comorbid conditions. abstract: The current outbreak of COVID-19 pandemic caused by SARS-CoV-2 has affected nearly 188 countries. Patients with severe COVID-19 are more commonly elderly and suffer from comorbidities such as hypertension, diabetes mellitus, coronary artery disease, chronic pulmonary disease, obesity, and cancer. Inflammatory bowel disease (IBD) affects as many as 6.8 million people globally, and a significant proportion of them are treated with immunosuppressants. Hence, there is an ongoing concern over the impact of COVID-19 on IBD patients and their susceptibility to it. So far, there are about 1439 IBD patients in the Surveillance Epidemiology of Coronavirus under Research Exclusion (SECURE-IBD) registry reported to be infected with SARS-CoV-2. There are many unique challenges and dilemmas that need to be taken into account when managing an IBD patient with COVID-19. The management of each patient should be individualized. The IBD societies and experts have strongly recommended that patients should not discontinue their IBD medications. If the patients have symptoms of COVID-19 or IBD flare-up, they are recommended to call their IBD physician first to discuss their medication. In addition, IBD patients are urged to practice social distancing strictly to minimize the chances of infection. As COVID-19 is rapidly evolving, our experience and understanding of its impact on the IBD population may potentially change in the near future. url: https://doi.org/10.20524/aog.2020.0547 doi: 10.20524/aog.2020.0547 id: cord-270079-vwnzp6zj author: Galanis, Nikiforos title: Coagulopathy in COVID-19 infection: a case of acute upper limb ischemia date: 2020-07-02 words: 1260.0 sentences: 70.0 pages: flesch: 39.0 cache: ./cache/cord-270079-vwnzp6zj.txt txt: ./txt/cord-270079-vwnzp6zj.txt summary: We report a case of severe coagulopathy manifesting with right upper limb arterial and deep vein thrombosis in an 80-year-old male patient with severe COVID-19 associated pneumonia. At that point, his coagulation laboratory tests were deranged, and he eventually developed dry gangrene in his right thumb and index finger, as well as a deep venous thromboembolism in his right axillary vein. Since the beginning of the pandemic, it has become evident that COVID-19 infection does not only affect the respiratory tract but in some patients it seems to evolve to a systemic disease with severe complications such as acute respiratory distress syndrome (ARDS) and multi-organ failure [1] . We present a case of an 80-year-old patient with confirmed COVID-19 infection, who developed severe coagulopathy with peripheral arterial infarcts and deep venous thromboembolism. Seven days later, while his general condition was deteriorating, he developed acute ischemia in his right thumb and index finger (Fig. 2) . abstract: Coagulation abnormalities and thrombosis have been recently identified as sequelae of severe infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report a case of severe coagulopathy manifesting with right upper limb arterial and deep vein thrombosis in an 80-year-old male patient with severe COVID-19 associated pneumonia. He clinically deteriorated and received care in the intensive care unit where he was intubated. At that point, his coagulation laboratory tests were deranged, and he eventually developed dry gangrene in his right thumb and index finger, as well as a deep venous thromboembolism in his right axillary vein. Despite receiving treatment dose anticoagulation and undergoing arterial embolectomy, revascularization was unsuccessful. Amputation of the right arm at the level of the elbow was considered, but the patient died from respiratory failure. url: https://doi.org/10.1093/jscr/rjaa204 doi: 10.1093/jscr/rjaa204 id: cord-317689-gp4x54pe author: Galanopoulou, Aristea S. title: EEG findings in acutely ill patients investigated for SARS‐CoV‐2/COVID‐19: A small case series preliminary report date: 2020-05-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Acute encephalopathy may occur in COVID‐19‐infected patients. We investigated whether medically indicated EEGs performed in acutely ill patients under investigation (PUIs) for COVID‐19 report epileptiform abnormalities and whether these are more prevalent in COVID‐19 positive than negative patients. METHODS: In this retrospective case series, adult COVID‐19 inpatient PUIs underwent EEGs for acute encephalopathy and/or seizure‐like events. PUIs had 8‐channel headband EEGs (Ceribell; 20 COVID‐19 positive, 6 COVID‐19 negative); 2 more COVID‐19 patients had routine EEGs. Overall, 26 Ceribell EEGs, 4 routine and 7 continuous EEG studies were reviewed. EEGs were interpreted by board‐certified clinical neurophysiologists (n = 16). EEG findings were correlated with demographic data, clinical presentation and history, and medication usage. Fisher's exact test was used. RESULTS: We included 28 COVID‐19 PUIs (30‐83 years old), of whom 22 tested positive (63.6% males) and 6 tested negative (33.3% male). The most common indications for EEG, among COVID‐19‐positive vs COVID‐19‐negative patients, respectively, were new onset encephalopathy (68.2% vs 33.3%) and seizure‐like events (14/22, 63.6%; 2/6, 33.3%), even among patients without prior history of seizures (11/17, 64.7%; 2/6, 33.3%). Sporadic epileptiform discharges (EDs) were present in 40.9% of COVID‐19‐positive and 16.7% of COVID‐19‐negative patients; frontal sharp waves were reported in 8/9 (88.9%) of COVID‐19‐positive patients with EDs and in 1/1 of COVID‐19‐negative patient with EDs. No electrographic seizures were captured, but 19/22 COVID‐19‐positive and 6/6 COVID‐19‐negative patients were given antiseizure medications and/or sedatives before the EEG. SIGNIFICANCE: This is the first preliminary report of EDs in the EEG of acutely ill COVID‐19‐positive patients with encephalopathy or suspected clinical seizures. EDs are relatively common in this cohort and typically appear as frontal sharp waves. Further studies are needed to confirm these findings and evaluate the potential direct or indirect effects of COVID‐19 on activating epileptic activity. url: https://www.ncbi.nlm.nih.gov/pubmed/32537529/ doi: 10.1002/epi4.12399 id: cord-352905-ge3u32hm author: Galimberti, Sara title: Tyrosine Kinase Inhibitors Play an Antiviral Action in Patients Affected by Chronic Myeloid Leukemia: A Possible Model Supporting Their Use in the Fight Against SARS-CoV-2 date: 2020-09-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SARS-CoV-2 is the viral agent responsible for the pandemic that in the first months of 2020 caused about 400,000 deaths. Among compounds proposed to fight the SARS-CoV-2-related disease (COVID-19), tyrosine kinase inhibitors (TKIs), already effective in Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (CML), have been proposed on the basis of their antiviral action already demonstrated against SARS-CoV-1. Very few cases of COVID-19 have been reported in Ph+ ALL and in CML Italian cohorts; authors suggested that this low rate of infections might depend on the use of TKIs, but the biological causes of this phenomenon remain unknown. In this study, the CML model was used to test if TKIs would sustain or not the viral replication and if they could damage patient immunity. Firstly, the infection and replication rate of torquetenovirus (TTV), whose load is inversely proportional to the host immunological control, have been measured in CML patients receiving nilotinib. A very low percentage of subjects were infected at baseline, and TTV did not replicate or at least showed a low replication rate during the follow-up, with a mean load comparable to the measured one in healthy subjects. Then, after gene expression profiling experiments, we found that several “antiviral” genes, such as CD28 and IFN gamma, were upregulated, while genes with “proviral” action, such as ARG-1, CEACAM1, and FUT4, were less expressed during treatment with imatinib, thus demonstrating that TKIs are not detrimental from the immunological point of view. To sum up, our data could offer some biological explanations to the low COVID-19 occurrence in Ph+ ALL and CML patients and sustain the use of TKIs in COVID-19, as already proposed by several international ongoing studies. url: https://doi.org/10.3389/fonc.2020.01428 doi: 10.3389/fonc.2020.01428 id: cord-340857-teq5txm9 author: Galloro, Giuseppe title: SAFETY IN DIGESTIVE ENDOSCOPY PROCEDURES IN THE COVID ERA RECOMMENDATIONS IN PROGRES OF THE ITALIAN SOCIETY OF DIGESTIVE ENDOSCOPY date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The new corona virus disease has started in Wuhan - China at the end of 2019 and quickly spread with a pandemic trend across the rest of the world. The scientific community is making an extraordinary effort to study and control the situation, but the results are just partial. Based on the most recent scientific literature and strong statements by the most prestigious international health institutions, the Italian Society of Digestive Endoscopy has drawn up some recommendations about the use of personal protective equipment, the correct way of dressing and undressing of endoscopists and nurses, before and after digestive endoscopy procedures. In addition, some other important indications are given to reduce the risk of contamination of healthcare providers during endoscopic activities, in the setting of a pandemic. Nevertheless, because of the very quick evolution of our knowledge on this issue, these recommendations must be considered as evolving, because they could change in a short time. url: https://api.elsevier.com/content/article/pii/S1590865820301912 doi: 10.1016/j.dld.2020.05.002 id: cord-338131-6y96eyoq author: Galvez, A. title: Perforated Marginal Ulcer in a COVID-19 Patient. Laparoscopy in these Trying Times? date: 2020-05-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s11695-020-04709-8 doi: 10.1007/s11695-020-04709-8 id: cord-310663-504p29hv author: Gambardella, Jessica title: Arginine and Endothelial Function date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus. url: https://doi.org/10.3390/biomedicines8080277 doi: 10.3390/biomedicines8080277 id: cord-255267-o8k5ep9y author: Gan, Connie Cai Ru title: Personal ventilation hood for protecting healthcare workers from aerosol-transmissible diseases date: 2020-07-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32771295/ doi: 10.1016/j.ajem.2020.07.036 id: cord-317242-e7000i2u author: Gandhi, Darshan title: Review of X-ray and computed tomography scan findings with a promising role of point of care ultrasound in COVID-19 pandemic date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As healthcare professionals continue to combat the coronavirus disease 2019 (COVID-19) infection worldwide, there is an increasing interest in the role of imaging and the relevance of various modalities. Since imaging not only helps assess the disease at the time of diagnosis but also aids evaluation of response to management, it is critical to examine the role of different modalities currently in use, such as baseline X-rays and computed tomography scans carefully. In this article, we will draw attention to the critical findings for the radiologist. Further, we will look at point of care ultrasound, an increasingly a popular tool in diagnostic medicine, as a component of COVID-19 management. url: https://www.ncbi.nlm.nih.gov/pubmed/33033574/ doi: 10.4329/wjr.v12.i9.195 id: cord-285360-svczr721 author: Ganesh, Aravind title: Ignorance is not bliss: managing uncertainty in acute stroke treatment in the COVID-19 era date: 2020-10-31 words: 1608.0 sentences: 68.0 pages: flesch: 34.0 cache: ./cache/cord-285360-svczr721.txt txt: ./txt/cord-285360-svczr721.txt summary: Treatment delays may seem inevitable with competing priorities like donning/doffing PPE, greater attention to the patient''s respiratory status with more frequent pre-emptive intubation, and a Fig. 1 During typical emergency medical scenarios like ischemic stroke, there are various factors that are immediately available ("known") at the time of decision-making for physicians, patients, and their caregivers/ proxies, whereas other factors are potentially knowable but lost to an "information bottleneck" and still others lie hidden behind a "knowledge barrier" (a). The COVID-19 pandemic has resulted in a constellation of systemic and workflow changes that have resulted in additional unique challenges in information flow for emergency medical decision-making (b). Nevertheless, by appreciating the underlying pitfalls in information flow, we can adopt a more proactive and nuanced approach to emergency decision-making and potentially mitigate the impact of COVID-19 on patient care (Fig. 1d) . abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33128573/ doi: 10.1007/s00234-020-02592-9 id: cord-256262-lwc4ghj2 author: Gangneux, Jean-Pierre title: Invasive fungal diseases during COVID-19: We should be prepared date: 2020-04-06 words: 1141.0 sentences: 60.0 pages: flesch: 36.0 cache: ./cache/cord-256262-lwc4ghj2.txt txt: ./txt/cord-256262-lwc4ghj2.txt summary: Among various causes of morbidity and mortality in COVID-19 patients, the frequency and impact of co-infections has still been poorly studied, particularly in patients with an acute respiratory distress syndrome (ARDS). In France, IFI account for a high risk of mortality in patients with co-morbidities from 9.2% to 40% depending on the fungal disease (8) . Invasive mucormycosis is increasingly reported (thanks to the improvement of diagnostic tools) in susceptible patients such as those suffering from diabetes, hematological malignancies, solid organ transplantation or chronic respiratory diseases and superficial injuries in burned patients or after local traumatism. In case of positivity of any of these tests, a confirmation step with blood biomarkers will be implemented depending on the positive results, with serum galactomannan and/or serum beta-D-glucan and/or cryptococcal antigenemia and/or blood qPCR for Aspergillus or mucorales, -national multicentric studies that aim to explore the risk of fungal co-infection during COVID-19 with joint consortia of ICU and Mycology specialists. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32307254/ doi: 10.1016/j.mycmed.2020.100971 id: cord-276782-3fpmatkb author: Garbey, M. title: A Model of Workflow in the Hospital During a Pandemic to Assist Management date: 2020-05-02 words: 5717.0 sentences: 295.0 pages: flesch: 61.0 cache: ./cache/cord-276782-3fpmatkb.txt txt: ./txt/cord-276782-3fpmatkb.txt summary: The objective is to assist management in anticipating the load of each care unit, such as the ICU, or ordering supplies, such as personal protective equipment, but also to retrieve key parameters that measure the performance of the health system facing a new crisis. In some hospitals, the floor might be shared by patients who are 92 recovering from COVID-19 and palliative care patients.Despite this, we will separate 93 these functional units in our model to clarify the workflow process according to what 94 each patient stage requires in terms of resources and time to deliver adequate care. Number of Staff required at each care unit per beds in reference to the Workflow of Figure 1 Let us describe the data set we are using to construct our model. abstract: We present a computational model of workflow in the hospital during a pandemic. The objective is to assist management in anticipating the load of each care unit, such as the ICU, or ordering supplies, such as personal protective equipment, but also to retrieve key parameters that measure the performance of the health system facing a new crisis. The model was fitted with good accuracy to France's data set that gives information on hospitalized patients and is provided online by the French government. The goal of this work is both practical in offering hospital management a tool to deal with the present crisis of COVID-19 and offering a conceptual illustration of the benefit of computational science during a pandemic. url: http://medrxiv.org/cgi/content/short/2020.04.28.20083154v1?rss=1 doi: 10.1101/2020.04.28.20083154 id: cord-304601-e6qlx1r6 author: Garcez, Flavia Barreto title: Delirium and adverse outcomes in hospitalized patients with COVID‐19. date: 2020-08-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Little is known about the association between acute mental changes and adverse outcomes in hospitalized adults with COVID‐19. OBJECTIVES: To investigate the occurrence of delirium in hospitalized patients with COVID‐19 and explore its association with adverse outcomes. DESIGN: Longitudinal observational study. SETTING: Tertiary university hospital dedicated to the care of severe cases of COVID‐19 in Sao Paulo, Brazil. PARTICIPANTS: 707 patients aged ≥50 years consecutively admitted to the hospital between March and May 2020. MEASUREMENTS: We completed detailed reviews of electronic medical records to collect our data. We identified delirium occurrence using the Chart‐based Delirium Identification Instrument (CHART‐DEL). Trained physicians with a background in geriatric medicine completed all CHART‐DEL assessments. We complemented our baseline clinical information using telephone interviews with participants or their proxy. Our outcomes of interest were in‐hospital death, length of stay, admission to intensive care, and ventilator utilization. We adjusted all multivariable analyses for age, sex, clinical history, vital signs, and relevant laboratory biomarkers (lymphocyte count, C‐reactive protein, glomerular filtration rate, D‐dimer, albumin). RESULTS: Overall, we identified delirium in 234 participants (33%). On admission, 86 (12%) were delirious. We observed 263 deaths (37%) in our sample, and in‐hospital mortality reached 55% in patients who experienced delirium. Delirium was associated with in‐hospital death, with an adjusted odds ratio [aOR] of 1.75 (95% confidence interval [95%CI]= 1.15‐2.66); the association held both in middle‐aged and older adults. Delirium was also associated with increased length of stay, admission to intensive care, and ventilator utilization. CONCLUSION: Delirium was independently associated with in‐hospital death in adults aged ≥50 years with COVID‐19. Despite the difficulties for patient care during the pandemic, clinicians should routinely monitor delirium when assessing severity and prognosis of COVID‐19 patients. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32835425/ doi: 10.1111/jgs.16803 id: cord-284387-cjziykrz author: Garcia-Castrillo, Luis title: European Society For Emergency Medicine position paper on emergency medical systems’ response to COVID-19 date: 2020-05-04 words: 2346.0 sentences: 125.0 pages: flesch: 44.0 cache: ./cache/cord-284387-cjziykrz.txt txt: ./txt/cord-284387-cjziykrz.txt summary: Second, protective measures by health services, especially in public and open environments like emergency departments (EDs) where isolation of potentially infected patients is a real challenge or clinical wards is vital [10] . Clinical care of suspected patients with COVID-19 should focus on early recognition, and immediate isolation, as well as appropriate infection prevention measures and control measures with care taken to optimise supportive care. (1) An informative, coordinated campaign for public and healthcare professionals, focused on mechanisms of contagion [4] , personal protection equipment (PPE) use, and a clinical pathway for the suspected patients infected with COVID-19. (5) The development and implementation of cleaning protocols, considering that coronavirus has been isolated on inanimate objects, and healthcare workers were infected by SARS, even without direct contact with sick patients [15] . The patient, relative or general practitioner may alert the emergency number indicating that a potential case of SARS-CoV-2 infection with severe symptoms is seeking care. abstract: The 2019 novel coronavirus acute respiratory epidemic is creating a stressed situation in all the health systems of the affected countries. Emergency medical systems and specifically the emergency departments as the front line of the health systems are suffering from overload and severe working conditions, the risk of contagion and transmission of the health professionals adds a substantial burden to their daily work. Under the perspective of European Society For Emergency Medicine, the recommendations provided by the health authorities are reviewed focus on the emergency department’s activity. url: https://doi.org/10.1097/mej.0000000000000701 doi: 10.1097/mej.0000000000000701 id: cord-355294-gifsqph6 author: García-Suárez, Julio title: Impact of hematologic malignancy and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study date: 2020-10-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Patients with cancer have been shown to have a higher risk of clinical severity and mortality compared to non-cancer patients with COVID-19. Patients with hematologic malignancies typically are known to have higher levels of immunosuppression and may develop more severe respiratory viral infections than patients with solid tumors. Data on COVID-19 in patients with hematologic malignancies are limited. Here we characterize disease severity and mortality and evaluate potential prognostic factors for mortality. METHODS: In this population-based registry study, we collected de-identified data on clinical characteristics, treatment and outcomes in adult patients with hematologic malignancies and confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection within the Madrid region of Spain. Our case series included all patients admitted to 22 regional health service hospitals and 5 private healthcare centers between February 28 and May 25, 2020. The primary study outcome was all-cause mortality. We assessed the association between mortality and potential prognostic factors using Cox regression analyses adjusted for age, sex, comorbidities, hematologic malignancy and recent active cancer therapy. RESULTS: Of 833 patients reported, 697 were included in the analyses. Median age was 72 years (IQR 60–79), 413 (60%) patients were male and 479 (69%) and 218 (31%) had lymphoid and myeloid malignancies, respectively. Clinical severity of COVID-19 was severe/critical in 429 (62%) patients. At data cutoff, 230 (33%) patients had died. Age ≥ 60 years (hazard ratios 3.17–10.1 vs < 50 years), > 2 comorbidities (1.41 vs ≤ 2), acute myeloid leukemia (2.22 vs non-Hodgkin lymphoma) and active antineoplastic treatment with monoclonal antibodies (2·02) were associated with increased mortality; conventional chemotherapy showed borderline significance (1.50 vs no active therapy). Conversely, Ph-negative myeloproliferative neoplasms (0.33) and active treatment with hypomethylating agents (0.47) were associated with lower mortality. Overall, 574 (82%) patients received antiviral therapy. Mortality with severe/critical COVID-19 was higher with no therapy vs any antiviral combination therapy (2.20). CONCLUSIONS: In this series of patients with hematologic malignancies and COVID-19, mortality was associated with higher age, more comorbidities, type of hematological malignancy and type of antineoplastic therapy. Further studies and long-term follow-up are required to validate these criteria for risk stratification. url: https://doi.org/10.1186/s13045-020-00970-7 doi: 10.1186/s13045-020-00970-7 id: cord-331519-ye4dtna5 author: Garibaldi, B. T. title: Patient trajectories and risk factors for severe outcomes among persons hospitalized for COVID-19 in the Maryland/DC region date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Risk factors for poor outcomes from COVID-19 are emerging among US cohorts, but patient trajectories during hospitalization ranging from mild-moderate, severe, and death and the factors associated with these outcomes have been underexplored. Methods: We performed a cohort analysis of consecutive COVID-19 hospital admissions at 5 Johns Hopkins hospitals in the Baltimore/DC area between March 4 and April 24, 2020. Disease severity and outcomes were classified using the WHO COVID-19 disease severity ordinal scale. Cox proportional-hazards regressions were performed to assess relationships between demographics, clinical features and progression to severe disease or death. Results: 832 COVID-19 patients were hospitalized; 633 (76.1%) were discharged, 113 (13.6%) died, and 85 (10.2%) remained hospitalized. Among those discharged, 518 (82%) had mild/moderate and 116 (18%) had severe illness. Mortality was statistically significantly associated with increasing age per 10 years (adjusted hazard ratio (aHR) 1.54; 95%CI 1.28-1.84), nursing home residence (aHR 2.13, 95%CI 1.41-3.23), Charlson comorbidity index (1.13; 95% CI 1.02-1.26), respiratory rate (aHR 1.13; 95%CI 1.09-1.17), D-dimer greater than 1mg/dL (aHR 2.79; 95% 1.53-5.09), and detectable troponin (aHR 2.79; 95%CI 1.53-5.09). In patients under 60, only male sex (aHR 1.7;95%CI 1.11-2.58), increasing body mass index (BMI) (aHR1.25 1.14-1.37), Charlson score (aHR 1.27; 1.1-1.46) and respiratory rate (aHR 1.16; 95%CI 1.13-1.2) were associated with severe illness or death. Conclusions: A combination of demographic and clinical features on admission is strongly associated with progression to severe disease or death in a US cohort of COVID-19 patients. Younger patients have distinct risk factors for poor outcomes. url: https://doi.org/10.1101/2020.05.24.20111864 doi: 10.1101/2020.05.24.20111864 id: cord-018303-dvuwhpyq author: Garibaldi, Brian T. title: Aeromedical Evacuation of Patients with Contagious Infections date: 2019-02-27 words: 9008.0 sentences: 454.0 pages: flesch: 47.0 cache: ./cache/cord-018303-dvuwhpyq.txt txt: ./txt/cord-018303-dvuwhpyq.txt summary: Topics include a review of the ecology of aircraft cabins and engineering features of aircraft ventilation systems that minimize the risk of disease transmission; examples of point source outbreaks related to air travel; in-flight preventive measures including the use of patient isolators; and US military and international policy and legal aspects of transporting patients with communicable diseases. Examples include in-flight transmission of tuberculosis, severe acute respiratory syndrome (SARS), smallpox, and measles.The chapter will also discuss experience in transporting patients with contagious diseases including viral hemorrhagic fevers and new patient isolation technologies that were used for the long-distance transport of patients with Ebola virus disease during the 2014–2016 West African epidemic. In response to concerns generated by lethal viral hemorrhagic fevers, and a possible need to transport patients with these diseases by air, the ventilation and air-conditioning systems on pressurized, long-range transport aircraft were studied to evaluate the aerodynamics of aerosolized microorganisms [19] . abstract: Most patients with infectious diseases, including biologic warfare casualties, can be safely transported by aeromedical evacuation (AE) using standard precautions. However, certain contagious diseases (e.g., tuberculosis, pneumonic plague, viral hemorrhagic fever) require transmission-based precautions to protect the other patients, medical personnel, and aircrew. AE planning for these patients must take into account international public health regulations. Given adequate resources, foresight, and expertise, the AE of infected patients and biologic warfare casualties can be safely accomplished. This chapter provides a review of the aeromedical evacuation of patients with communicable diseases. Topics include a review of the ecology of aircraft cabins and engineering features of aircraft ventilation systems that minimize the risk of disease transmission; examples of point source outbreaks related to air travel; in-flight preventive measures including the use of patient isolators; and US military and international policy and legal aspects of transporting patients with communicable diseases. Examples include in-flight transmission of tuberculosis, severe acute respiratory syndrome (SARS), smallpox, and measles.The chapter will also discuss experience in transporting patients with contagious diseases including viral hemorrhagic fevers and new patient isolation technologies that were used for the long-distance transport of patients with Ebola virus disease during the 2014–2016 West African epidemic. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123148/ doi: 10.1007/978-3-030-15903-0_20 id: cord-350166-loxe11d6 author: Garmendia, Onintza title: Low-cost, easy-to-build non-invasive pressure support ventilator for under-resourced regions: open source hardware description, performance and feasibility testing date: 2020-04-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: AIM: Current pricing of commercial mechanical ventilators in low/middle-income countries (LMICs) markedly restricts their availability, and consequently a considerable number of patients with acute/chronic respiratory failure cannot be adequately treated. Our aim was to design and test an affordable and easy-to-build non-invasive bilevel pressure ventilator to allow reducing the serious shortage of ventilators in LMICs. METHODS: The ventilator was built using off-the-shelf materials available via e-commerce and was based on a high-pressure blower, two pressure transducers and an Arduino Nano controller with a digital display (total retail cost <75 US$), with construction details open source provided for free replication. The ventilator was evaluated (and compared with a commercially available device (Lumis-150, Resmed): a) in the bench using an actively breathing patient simulator mimicking a range of obstructive/restrictive disease and b) in 12 healthy volunteers wearing a high airway resistance and thoracic/abdominal bands to mimic obstructive/restrictive patients. RESULTS: The designed ventilator provided inspiratory/expiratory pressures up to 20/10 cmH(2)O, respectively, with no faulty triggering or cycling both in the bench test and in volunteers. Breathing difficulty score rated (1–10 scale) by the loaded breathing subjects was significantly (p<0.005) decreased from 5.45±1.68 without support to 2.83±1.66 when using the prototype ventilator, which showed no difference with the commercial device (2.80±1.48; p=1.000). CONCLUSION: The low-cost, easy-to-build non-invasive ventilator performs similarly as a high-quality commercial device, with its open-source hardware description, will allow for free replication and use in LMICs, facilitating application of this life-saving therapy to patients who otherwise could not be treated. url: https://www.ncbi.nlm.nih.gov/pubmed/32312862/ doi: 10.1183/13993003.00846-2020 id: cord-033019-4eo037jp author: Garnier, Marc title: Answer to the letter by Niño et al date: 2020-10-02 words: 1095.0 sentences: 53.0 pages: flesch: 53.0 cache: ./cache/cord-033019-4eo037jp.txt txt: ./txt/cord-033019-4eo037jp.txt summary: Indeed, the transition, even partial, from in-face to teleconsultation must be prepared and a minimum of prerequisites are necessary, such as: the availability of high-performance computer equipment; the availability of a secretariat to organise the call planning and the sending before the teleconsultation of the documents to be prepared by the patient; the use of secure applications to preserve the confidentiality of the medical data exchanged; or the training of anaesthetists in the institutional tools made available. As this PCR must be carried out as close as possible to the surgery, we agree that the result cannot be available at the time of the anaesthetic consultation. In other cases (i.e. non-aerosol-generating care and no prolonged contact within one metre), the wearing of a simple surgical mask is recommended, including for the care of a proven COVID-19 patient. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529826/ doi: 10.1016/j.accpm.2020.09.006 id: cord-322990-q07yy5k8 author: Garutti, Mattia title: Seven Shades of Black Thoughts: COVID-19 and Its Psychological Consequences on Cancer Patients date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: An outbreak of novel coronavirus disease (COVID-19) that started in China at the end of 2019 has rapidly spread all over the world. COVID-19 is plaguing people not only physically but also psychologically, and cancer patients are particularly exposed to this emotional threat. Herein, we describe the psychological threats posed by COVID-19 to cancer patients. Our analysis is based on the concerns of our patients during our daily clinical interactions in both outpatient and inpatient settings. We have summarized the patients' psychological issues: logistic overload, loneliness, fear, oxymoronic thoughts, helplessness, frustration, and emotional siege. We describe these psychological threats, provide clinical context for them, and offer practical suggestions for managing them, for the benefit of patients, their caregivers, and clinicians. Our hope is that, by sharing our clinical experience, we can help other oncologists increase their awareness of the psychological impact of the pandemic on cancer patients and implement solutions. Managing these challenges now should translate into improved standards of care when this infective storm is over. Paradoxically, COVID-19 could be an opportunity to learn how to better manage cancer care. url: https://www.ncbi.nlm.nih.gov/pubmed/32766162/ doi: 10.3389/fonc.2020.01357 id: cord-308112-w96ncfla author: Gautret, Philippe title: Nullane salus extra ecclesiam date: 2020-08-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Randomized clinical trials are not relevant for infectious disease outbreaks due to a new pathogen, for which public health decisions have to be made urgently. An approach based on group comparisons, in silico, may provide valuable results in a reasonably short period of time for a negligible amount of money. url: https://api.elsevier.com/content/article/pii/S2052297520300664 doi: 10.1016/j.nmni.2020.100714 id: cord-343715-y594iewi author: Gavriatopoulou, Maria title: Organ-specific manifestations of COVID-19 infection date: 2020-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Although COVID-19 presents primarily as a lower respiratory tract infection transmitted via air droplets, increasing data suggest multiorgan involvement in patients that are infected. This systemic involvement is postulated to be mainly related to the SARS-CoV-2 virus binding on angiotensin-converting enzyme 2 (ACE2) receptors located on several different human cells. Lung involvement is the most common serious manifestation of the disease, ranging from asymptomatic disease or mild pneumonia, to severe disease associated with hypoxia, critical disease associated with shock, respiratory failure and multiorgan failure or death. Among patients with COVID-19, underlying cardiovascular comorbidities including hypertension, diabetes and especially cardiovascular disease, has been associated with adverse outcomes, whereas the emergence of cardiovascular complications, including myocardial injury, heart failure and arrhythmias, has been associated with poor survival. Gastrointestinal symptoms are also frequently encountered and may persist for several days. Haematological complications are frequent as well and have been associated with poor prognosis. Furthermore, recent studies have reported that over a third of infected patients develop a broad spectrum of neurological symptoms affecting the central nervous system, peripheral nervous system and skeletal muscles, including anosmia and ageusia. The skin, the kidneys, the liver, the endocrine organs and the eyes are also affected by the systemic COVID-19 disease. Herein, we provide a comprehensive overview of the organ-specific systemic manifestations of COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32720223/ doi: 10.1007/s10238-020-00648-x id: cord-284526-a5kgo4ct author: Gavriilaki, Eleni title: Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses date: 2020-08-27 words: 6004.0 sentences: 319.0 pages: flesch: 32.0 cache: ./cache/cord-284526-a5kgo4ct.txt txt: ./txt/cord-284526-a5kgo4ct.txt summary: Experience from previous coronaviruses has triggered hypotheses on the role of endothelial dysfunction in the pathophysiology of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which are currently being tested in preclinical and clinical studies. Recent evidence suggests that signs and symptoms of severe coronavirus disease-2019 (COVID-19) infection resemble the clinical phenotype of endothelial dysfunction and share mutual pathophysiological mechanisms [1] . Experience from previous coronaviruses has triggered studies testing hypotheses on the role of the endothelial dysfunction in patients with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Α high rate of VTE (43%, mainly PE) overall was reported in another series of 150 ICU patients in which patients with COVID-19associated acute respiratory distress syndrome (ARDS) had higher rates of thrombotic complications compared with non-COVID-19-ARDS [65] . Autoantibodies against human epithelial cells and endothelial cells after severe acute respiratory syndrome (SARS)-associated coronavirus infection abstract: PURPOSE OF REVIEW: To review current literature on endothelial dysfunction with previous coronaviruses, and present available data on the role of endothelial dysfunction in coronavirus disease-2019 (COVID-19) infection in terms of pathophysiology and clinical phenotype RECENT FINDINGS: Recent evidence suggests that signs and symptoms of severe COVID-19 infection resemble the clinical phenotype of endothelial dysfunction, implicating mutual pathophysiological pathways. Dysfunction of endothelial cells is believed to mediate a variety of viral infections, including those caused by previous coronaviruses. Experience from previous coronaviruses has triggered hypotheses on the role of endothelial dysfunction in the pathophysiology of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which are currently being tested in preclinical and clinical studies. SUMMARY: Endothelial dysfunction is the common denominator of multiple clinical aspects of severe COVID-19 infection that have been problematic for treating physicians. Given the global impact of this pandemic, better understanding of the pathophysiology could significantly affect management of patients. url: https://doi.org/10.1007/s11906-020-01078-6 doi: 10.1007/s11906-020-01078-6 id: cord-319037-77l9wdyb author: Gavriilaki, Eleni title: A New Era in Endothelial Injury Syndromes: Toxicity of CAR-T Cells and the Role of Immunity date: 2020-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Immunotherapy with chimeric antigen receptor T (CAR-T cells) has been recently approved for patients with relapsed/refractory B-lymphoproliferative neoplasms. Along with great efficacy in patients with poor prognosis, CAR-T cells have been also linked with novel toxicities in a significant portion of patients. Cytokine release syndrome (CRS) and neurotoxicity present with unique clinical phenotypes that have not been previously observed. Nevertheless, they share similar characteristics with endothelial injury syndromes developing post hematopoietic cell transplantation (HCT). Evolution in complement therapeutics has attracted renewed interest in these life-threatening syndromes, primarily concerning transplant-associated thrombotic microangiopathy (TA-TMA). The immune system emerges as a key player not only mediating cytokine responses but potentially contributing to endothelial injury in CAR-T cell toxicity. The interplay between complement, endothelial dysfunction, hypercoagulability, and inflammation seems to be a common denominator in these syndromes. As the indications for CAR-T cells and patient populations expand, there in an unmet clinical need of better understanding of the pathophysiology of CAR-T cell toxicity. Therefore, this review aims to provide state-of-the-art knowledge on cellular therapies in clinical practice (indications and toxicities), endothelial injury syndromes and immunity, as well as potential therapeutic targets. url: https://www.ncbi.nlm.nih.gov/pubmed/32485958/ doi: 10.3390/ijms21113886 id: cord-302821-b9ikg0xy author: Gawałko, Monika title: COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications date: 2020-09-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19) is a novel, highly transmittable and severe strain disease, which has rapidly spread worldwide. Despite epidemiological evidence linking COVID-19 withcardiovascular diseases, little is knownabout whether and how COVID-19 influences atrial fibrillation(AF), the most prevalent arrhythmia in clinical practice. Here, we review the available evidence for prevalence and incidence of AF in patients infected with the severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) and discuss disease management approaches and potential treatment options for COVID-19 infected AF patients. url: https://www.sciencedirect.com/science/article/pii/S2352906720303298?v=s5 doi: 10.1016/j.ijcha.2020.100631 id: cord-264751-2l3cqhe2 author: Gawie-Rotman, Moran title: Purpuric rash and fever among hospitalized children aged 0–18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology date: 2019-02-22 words: 3257.0 sentences: 171.0 pages: flesch: 44.0 cache: ./cache/cord-264751-2l3cqhe2.txt txt: ./txt/cord-264751-2l3cqhe2.txt summary: 8e11 The purpose of the present study is to describe all the cases with PRF occurring in children aged 0 18 years diagnosed and hospitalized at the pediatric departments of the Soroka University Medical Center, Beer-Sheva, Israel, during the period 2005 2016, and to compare their microbiologic laboratory, clinical, therapeutic and outcome characteristics in relation to the various etiologies of this syndrome. We conducted a retrospective study enrolling all the children aged 0 -18 years hospitalized at the pediatric departments of the Soroka University Medical Center, Beer-Sheva, Israel, during the period 01/2005 12/2016, with a diagnosis of purpuric rash accompanied by a fever >38 C. The aim of the present study was to determine the etiology of all cases of PRF occurring in children aged 0 18 years hospitalized in southern Israel during the period 2005 2016, and compare their microbiologic, laboratory, clinical, therapeutic and outcome characteristics in relation to the various etiologies of this syndrome. abstract: BACKGROUND: The evaluation of children with purpuric rash and fever (PRF) is controversial. Although many of them have viral infections, on occasion such patients may be infected with Neisseria meningitidis. We described all children aged 0–18 years with PRF in southern Israel during the period 2005 – 2016 and compared their microbiologic, laboratory, clinical and outcome characteristics in relation to various etiologies of this syndrome. METHODS: Data were summarized from electronic patient and microbiology files. Viral diagnoses were made by serology and/or PCR. RESULTS: Sixty-nine children with PRF were admitted; 30 (43.48%), 9 (13.04%) and 30 (43.48%) had a syndrome of bacterial, viral or non-established etiology, respectively. N. meningitidis infection was diagnosed in 16/69 (23.19%) patients and in 16/30 (53.33%) patients with bacterial etiology; 14/30 (46.67%) patients suffered from a non-invasive bacterial disease (9 with Rickettsial disease). Adenovirus and Influenza B (3 and 2 cases, respectively) represented the most frequent etiologic agents among patients with viral etiology. More patients with PRF of bacterial etiology were older, of Bedouin ethnicity, looked ill on admission, had higher rates of meningitis and were treated more frequently with antibiotics compared with patients with non-bacterial PRF. Fatality rates among patients with bacterial, viral and non-established etiology were 5/30 (16.7%), 0% and 2/39 (5.1%). CONCLUSIONS: Although PFR was uncommon, high rates of meningococcal infections were recorded in children with PRF, which was associated with high fatality rates. Rickettsial infections were frequent, emphasizing the need for a high index of suspicion for this disease in endemic geographic areas. url: https://www.sciencedirect.com/science/article/pii/S1875957218303735 doi: 10.1016/j.pedneo.2019.02.002 id: cord-274934-s8xppipe author: Gebbia, Vittorio title: Patients With Cancer and COVID-19: A WhatsApp Messenger-Based Survey of Patients’ Queries, Needs, Fears, and Actions Taken date: 2020-05-15 words: 3391.0 sentences: 185.0 pages: flesch: 46.0 cache: ./cache/cord-274934-s8xppipe.txt txt: ./txt/cord-274934-s8xppipe.txt summary: PURPOSE: This descriptive investigation was undertaken at three oncology units to report queries, needs, and fears related to severe acute respiratory syndrome coronavirus 2 (COVID-19) of patients with cancer and to avoid uncontrolled treatment delays or withdrawal, behavioral mistakes, and panic. In this article, we report real-world data and a descriptive analysis of patients'' needs and fears as well as of misinformation obtained through the WhatsApp instant messaging system (WM; Facebook, Menlo Park, CA) in daily practice during the COVID-19 pandemic. To better understand how patients talk and feel about this potential critical health CONTEXT Key Objective Are instant messaging systems useful to oncologists to care for patients with cancer and to mitigate their anxieties and fears during the severe acute respiratory syndrome coronavirus 2 (COVID-19) outbreak? Knowledge Generated The WhatsApp instant messaging system is a useful and rapid tool to inform and reassure patients with cancer and to facilitate patient triage in a real-word setting of the pandemic spread of COVID-19. abstract: PURPOSE: This descriptive investigation was undertaken at three oncology units to report queries, needs, and fears related to severe acute respiratory syndrome coronavirus 2 (COVID-19) of patients with cancer and to avoid uncontrolled treatment delays or withdrawal, behavioral mistakes, and panic. PATIENTS AND METHODS: All queries spontaneously delivered through the WhatsApp instant messaging system commonly used by patients to communicate with oncology units were collected and grouped by homology in five categories. Responses to the queries were given according to recommendations by the Italian Association of Medical Oncology through WhatsApp and by subsequent phone calls. Patients were also classified according to the site of the primary tumor, stage of disease, and current treatments. Analysis of the association between these data and queries was carried out. RESULTS: The social scenario in Italy is a nationwide lockdown except for hospitals, pharmacies, and food supplies. Overall, 446 different patients’ WhatsApp conversations were analyzed between March 1 and March 13 and comprised the following: requirement of visit delay by patients undergoing oral therapies or in follow-up, delays in chemotherapy or immunotherapy administration, queries about possible immunosuppression, and changes in lifestyle or daily activities. Delay requirements were statistically more frequent among patients with prostate or breast cancer compared with those with lung or pancreatic cancer. Actions taken by oncologists are also reported. CONCLUSION: To our knowledge, the WhatsApp instant messaging system has been occasionally used in other medical settings with controversial results. In our experience, WhatsApp turned out to be adequate to give a rapid answer to most queries from patients with cancer in the COVID-19 pandemic scenario. url: https://doi.org/10.1200/go.20.00118 doi: 10.1200/go.20.00118 id: cord-310685-gi2ycrfk author: Geiling, James title: Critical Care of the Morbidly Obese in Disaster date: 2010-10-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The prevalence of obesity in the United States is increasing, with extreme morbid obesity of body mass index greater than 40 increasing twice as fast as obesity in general. With the increased weight comes an increased risk of comorbidities, including type 2 diabetes mellitus, cardiovascular disease, respiratory problems such as obstructive sleep apnea or restrictive lung disease, skin disorders such as intertrigo and cellulitis, and urinary incontinence. Thus, patients exposed to a variety of disasters not only are increasingly overweight but also have an associated number of coexistent medical conditions that require increased support with medical devices and medications. This article focuses on management of the morbidly obese patients during disasters. url: https://doi.org/10.1016/j.ccc.2010.06.001 doi: 10.1016/j.ccc.2010.06.001 id: cord-330701-k68b0wqe author: Gerc, Vjekoslav title: Cardiovascular Diseases (CVDs) in COVID-19 Pandemic Era date: 2020-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: COVID-19 is the disease caused by an infection of the SARS-CoV-2 virus, previously known as 2019 Novel Coronavirus (2019-nCoV) respiratory disease. World Health Organization (WHO) declared the official name as COVID-19 in February 2020 and in 11(th) March 2020 declared COVID-19 as Global Pandemic. In June 6(th) 2020, over 7 million cases registered in the world, recovered 3.4 million and death over 402.000. AIM: The aim of this study is to retreive published papers about COVID-19 infection deposited in PubMed data base and analyzed current results of investigations regarding morbidity and mortality rates as consequences of COVID-19 infection and opinions of experts about treatment of afected patients with COVID-19 who have Cardiovascular diseases (CVDs). METHODS: It’s used method of descriptive analysis of the published papers with described studies about Corona virus connected with CVDs. RESULTS: After searching current scientific literature (on PubMed till today is deposited more than 1.000 papers about COVID-19 with consequences in almost every medical disciplines), we have acknowledged that till today not any Evidence Based Medicine (EBM) study in the world. Also, there are no unique proposed ways of treatments and drugs to protect patients, especially people over 65 years old, who are very risk group to be affected with COVID-19, including patients with CVDs. Vaccine against COVID-19 is already produced and being in phases of testing in praxis in treatment of COVID-19 at affected patients, but the opinions of experts and common people whole over the world about vaccination are full of controversis. CONCLUSION: Frequent hand washing, avoiding crowds and contact with sick people, and cleaning and disinfecting frequently touched surfaces can help prevent coronavirus infections are the main proposal of WHO experts in current Guidelines, artefacts stored on a web site. Those preventive measures at least can help to everybody, including also the patients who have evidenced CVDs in their histories of illness. Authors analyzed most important dilemmas about all aspects of CVDs, including etipathogenesis, treatment with current drugs and use of potential discovered vaccines against COVID-19 infection, described in scientific papers deposited in PubMed data base. url: https://www.ncbi.nlm.nih.gov/pubmed/32843866/ doi: 10.5455/msm.2020.32.158-164 id: cord-022292-msz4au4b author: Gershan, William M. title: Cough date: 2009-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155534/ doi: 10.1016/b978-0-7216-9131-2.50006-3 id: cord-351224-jeedo5mc author: GeurtsvanKessel, Corine H. title: An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the selected assays there is a wide diversity in assay performance in different scenarios and when correlated to virus neutralizing antibodies. The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies. The large variety of available serological assays requires proper assay validation before deciding on deployment of assays for specific applications. url: https://doi.org/10.1038/s41467-020-17317-y doi: 10.1038/s41467-020-17317-y id: cord-010786-w3kjc6so author: Ghaderi, Sara title: Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway date: 2019-12-23 words: 3524.0 sentences: 180.0 pages: flesch: 38.0 cache: ./cache/cord-010786-w3kjc6so.txt txt: ./txt/cord-010786-w3kjc6so.txt summary: title: Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway We conducted a population-based registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. We aim to examine risk of acute hospitalization among MS patients up to 3 months following influenza infection and pandemic vaccination in a large population-based cohort consisting of 6755 MS patients using nationwide populationbased Norwegian registries. We applied the self-controlled case series (SCCS) method to estimate incidence rate ratios (IRRs) of acute hospitalization with MS diagnosis in various risk periods following a diagnosis of influenza infection or vaccination, compared with a background period [22] . In model III, the IRR of acute hospitalization among patients was estimated following a diagnosis of seasonal influenza infection in the period from 1st of January, 2008 through 15st May, 2014, excluding the pandemic season (from September 2009-May 2010). abstract: Patients with multiple sclerosis (MS) are at increased risk of infections and related worsening of neurological function. Influenza infection has been associated with increased risk of various neurological complications. We conducted a population-based registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. The entire Norwegian population in the years 2008–2014 was defined as our study population (N = 5,219,296). Information on MS diagnosis, influenza infection and vaccination were provided by Norwegian national registries. The self-controlled case series method was used to estimate incidence rate ratios (IRRs) with 95% confidence intervals (95% CI) in defined risk periods. 6755 MS patients were identified during the study period. Average age at first registration of an MS diagnosis was 51.8 years among men and 49.9 years among females (66.9%). The IRR for emergency hospitalization among MS patients the first week after an influenza diagnosis was 3.4 (95% CI 2.4–4.8). The IRR was 5.6 (95% CI 2.7–11.3) after pandemic influenza, and 4.8 (95% CI 3.1–7.4) after seasonal influenza. Pandemic vaccination did not influence risk of hospitalization [IRR within the first week: 0.7 (95% CI 0.5–1.0)]. Among MS patients, influenza infection was associated with increased risk for acute hospitalization while no increased risk was observed after pandemic vaccination. Influenza vaccination could prevent worsening of MS-related symptoms as well as risk of hospitalization. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222066/ doi: 10.1007/s10654-019-00595-2 id: cord-351896-j6h02ab5 author: Ghannam, Malik title: Neurological involvement of coronavirus disease 2019: a systematic review date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: In December 2019, unexplained cases of pneumonia emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease 2019 (COVID-2019) outbreak, a pandemic. OBJECTIVE: To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options. METHODS: We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 where neurological involvement was evident. RESULTS: We were able to identify 82 cases of COVID-19 with neurological complications. The mean age was 62.3 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n = 40) had cerebrovascular insults, 28% (n = 23) had neuromuscular disorders, and 23% of the patients (n = 19) had encephalitis or encephalopathy. CONCLUSIONS: Neurological manifestations of COVID-19 are not rare, especially large vessel stroke, Guillain–Barre syndrome, and meningoencephalitis. Moving forward, further studies are needed to clarify the prevalence of the neurological complications of SARS-CoV-2 infection, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00415-020-09990-2) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32561990/ doi: 10.1007/s00415-020-09990-2 id: cord-257344-d13at1y5 author: Ghasemiyeh, Parisa title: COVID-19 Outbreak: Challenges in Pharmacotherapy Based on Pharmacokinetic and Pharmacodynamic Aspects of Drug Therapy in Patients with Moderate to Severe Infection date: 2020-09-18 words: 5683.0 sentences: 297.0 pages: flesch: 41.0 cache: ./cache/cord-257344-d13at1y5.txt txt: ./txt/cord-257344-d13at1y5.txt summary: Patients with predisposing diseases are highly prone to COVID-19 and manifesting severe infection especially with organ function damage such as acute respiratory distress syndrome, acute kidney injury, septic shock, ventilator-associated pneumonia, and death. Patients with underlying diseases are highly prone to present with severe infection especially with organ function damage such as acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), septic shock, and ventilator-associated pneumonia (VAP) 10, 13 . Results of another systematic review and meta-analysis on 53 randomized clinical trials on administration of hydroxychloroquine in COVID-19 management revealed that hydroxychloroquine administration (case group) was significantly associated with higher incidence of total adverse effects in comparison to placebo or no treatment (control group) in overall population of patients with COVID-19 45 . Almost all of the potential drugs in COVID-19 treatment containing chloroquine, hydroxychloroquine, ribavirin, and lopinavir/ritonavir have hepatic metabolism. abstract: The new coronavirus (COVID-19) was first detected in Wuhan city of China in December 2019. Most patients infected with COVID-19 had clinical presentations of dry cough, fever, dyspnea, chest pain, fatigue and malaise, pneumonia, and bilateral infiltration in chest CT. Soon COVID-19 was spread around the world and became a pandemic. Now many patients around the world are suffering from this disease. Patients with predisposing diseases are highly prone to COVID-19 and manifesting severe infection especially with organ function damage such as acute respiratory distress syndrome, acute kidney injury, septic shock, ventilator-associated pneumonia, and death. Till now many drugs have been considered in the treatment of COVID-19 pneumonia, but pharmacotherapy in elderly patients and patients with pre-existing comorbidities is highly challenging. In this review, different potential drugs which have been considered in COVID-19 treatment have been discussed in detail. Also, challenges in the pharmacotherapy of COVID-19 pneumonia in patients with the underlying disease have been considered based on pharmacokinetic and pharmacodynamic aspects of these drugs. url: https://www.ncbi.nlm.nih.gov/pubmed/32980626/ doi: 10.1016/j.hrtlng.2020.08.025 id: cord-316666-qif1k62t author: Ghati, Nirmal title: Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial date: 2020-10-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To assess the impact of adding statin (atorvastatin) and/or aspirin on clinical deterioration in patients infected with SARS-CoV-2 who require hospitalisation. The safety of these drugs in COVID-19 patients will also be evaluated. TRIAL DESIGN: This is a single-centre, prospective, four-arm parallel design, open-label, randomized control trial. PARTICIPANTS: The study will be conducted at National Cancer Institute (NCI), Jhajjar, Haryana, which is a part of All India Institute of Medical Sciences (AIIMS), New Delhi, and has been converted into a dedicated COVID-19 management centre since the outbreak of the pandemic. All RT-PCR confirmed cases of SARS-CoV-2 infection with age ≥ 40 years and < 75 years requiring hospital admission (patients with WHO clinical improvement ordinal score 3 to 5) will be included in the trial. Written informed consent will be taken for all recruited patients. Patients with a critical illness (WHO clinical improvement ordinal score > 5), documented significant liver disease/dysfunction (aspartate transaminase [AST] / alanine aminotransferase [ALT] > 240), myopathy and rhabdomyolysis (creatine phosphokinase [CPK] > 5x normal), allergy or intolerance to statins or aspirin, prior statin or aspirin use within 30 days, history of active gastrointestinal bleeding in past three months, coagulopathy, thrombocytopenia (platelet count < 100000/ dl), pregnancy, active breastfeeding, or inability to take oral or nasogastric medications will be excluded. Patients refusing to give written consent and taking drugs that are known to have a significant drug interaction with statin or aspirin [including cyclosporine, HIV protease inhibitors, hepatitis C protease inhibitor, telaprevir, fibric acid derivatives (gemfibrozil), niacin, azole antifungals (itraconazole, ketoconazole), clarithromycin and colchicine] will also be excluded from the trial. INTERVENTION AND COMPARATOR: In this study, the benefit and safety of atorvastatin (statin) and/or aspirin as adjuvant therapy will be compared with the control group receiving usual care for management of COVID-19. Atorvastatin will be prescribed as 40 mg oral tablets once daily for ten days or until discharge, whichever is earlier. The dose of aspirin will be 75 mg once daily for ten days or until discharge, whichever is earlier. All other therapies will be administered according to the institute’s COVID-19 treatment protocol and the treating physician’s clinical judgment. MAIN OUTCOMES: All study participants will be prospectively followed up for ten days or until hospital discharge, whichever is longer for outcomes. The primary outcome will be clinical deterioration characterized by progression to WHO clinical improvement ordinal score ≥ 6 (i.e., endotracheal intubation, non-invasive mechanical ventilation, pressor agents, renal replacement therapy, ECMO requirement, and mortality). The secondary outcomes will be change in serum inflammatory markers (C-reactive protein and Interleukin-6), Troponin I, and creatine phosphokinase (CPK) from time zero to 5th day of study enrolment or 7th day after symptom onset, whichever is later. Other clinical outcomes that will be assessed include progression to Acute Respiratory Distress Syndrome (ARDS), shock, ICU admission, length of ICU admission, length of hospital admission, and in-hospital mortality. Adverse drug effects like myalgia, myopathy, rhabdomyolysis, hepatotoxicity, and bleeding will also be examined in the trial to assess the safety of the interventions. RANDOMISATION: The study will use a four-arm parallel-group design. A computer-generated permuted block randomization with mixed block size will be used to randomize the participants in a 1:1:1:1 ratio to group A (atorvastatin with conventional therapy), group B (aspirin with conventional therapy), group C (aspirin + atorvastatin with conventional therapy), and group D (control; only conventional therapy). BLINDING (MASKING): The study will be an open-label trial. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): As there is no existing study that has evaluated the role of aspirin and atorvastatin in COVID-19 patients, formal sample size calculation has not been done. Patients satisfying the inclusion and exclusion criteria will be recruited during six months of study period. Once the first 200 patients are included in each arm (i.e., total 800 patients), the final sample size calculation will be done on the basis of the interim analysis of the collected data. TRIAL STATUS: The institutional ethical committee has approved the study protocol (Protocol version 3.0 [June 2020]). Participant recruitment starting date: 28(th) July 2020 Participant recruitment ending date: 27(th) January 2021 Trial duration: 6 months TRIAL REGISTRATION: The trial has been prospectively registered in Clinical Trial Registry – India (ICMR- NIMS): Reference no. CTRI/2020/07/026791 (registered on 25 July 2020)]. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest of expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13063-020-04840-y. url: https://www.ncbi.nlm.nih.gov/pubmed/33126910/ doi: 10.1186/s13063-020-04840-y id: cord-356040-qdpkidn8 author: Ghazawi, Feras M. title: Infection risk of dermatologic therapeutics during the COVID‐19 pandemic: an evidence‐based recalibration date: 2020-07-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Recommendations were made recently to limit or stop the use of oral and systemic immunotherapies for skin diseases due to potential risks to the patients during the current severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) COVID‐19 pandemic. Herein, we attempt to identify potentially safe immunotherapies that may be used in the treatment of cutaneous diseases during the current COVID‐19 pandemic. We performed a literature review to approximate the risk of SARS‐CoV‐2 infection, including available data on the roles of relevant cytokines, cell subsets, and their mediators in eliciting an optimal immune response against respiratory viruses in murine gene deletion models and humans with congenital deficiencies were reviewed for viral infections risk and if possible coronaviruses specifically. Furthermore, reported risk of infections of biologic and non‐biologic therapeutics for skin diseases from clinical trials and drug data registries were evaluated. Many of the immunotherapies used in dermatology have data to support their safe use during the COVID‐19 pandemic including the biologics that target IgE, IL‐4/13, TNF‐α, IL‐17, IL‐12, and IL‐23. Furthermore, we provide evidence to show that oral immunosuppressive medications such as methotrexate and cyclosporine do not significantly increase the risk to patients. Most biologic and conventional immunotherapies, based on doses and indications in dermatology, do not appear to increase risk of viral susceptibility and are most likely safe for use during the COVID‐19 pandemic. The limitation of this study is availability of data on COVID‐19. url: https://www.ncbi.nlm.nih.gov/pubmed/32621284/ doi: 10.1111/ijd.15028 id: cord-271262-xglhx928 author: Ghia, Samit title: “ANESTHESIA STAT” TO INTUBATE A COVID-19 PATIENT: IMPLICATIONS FOR THE ANESTHESIOLOGIST date: 2020-05-15 words: 3280.0 sentences: 184.0 pages: flesch: 37.0 cache: ./cache/cord-271262-xglhx928.txt txt: ./txt/cord-271262-xglhx928.txt summary: Although reducing exposure of medical personnel is of obvious importance, there has been a dearth of literature discussing clinical strategies during the induction and intubation of COVID-19 patients. Ketamine could be a good agent for COVID-19 patient inductions; however, the anesthesiologist must be wary of cardiac failure with induction doses, especially if there is any preexisting history of cardiac disease or concern for viral cardiomyopathy. Prior to entering the COVID-19 patient''s room, a review of the chart or a discussion with the primary team should include past medical history, current hemodynamic state, pertinent labs and findings, current medication regimens and the need to intubate over other strategies to improve oxygenation and ventilation. Upon entering the COVID-19 patient room, after securing appropriate personal and procedural equipment, the anesthesiologist should quickly move to the head of the bed while assessing the patient''s current oxygenation and airway. abstract: nan url: https://api.elsevier.com/content/article/pii/S1053077020304778 doi: 10.1053/j.jvca.2020.05.016 id: cord-290611-fhaguv3f author: Ghio, Stefano title: Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hospital in Northern Italy date: 2020-09-22 words: 3755.0 sentences: 158.0 pages: flesch: 44.0 cache: ./cache/cord-290611-fhaguv3f.txt txt: ./txt/cord-290611-fhaguv3f.txt summary: Since the onset of coronavirus disease 2019 (COVID19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence has shown that patients with confirmed COVID-19 may present elevated blood levels of high-sensitivity TnI (hs-TnI) during hospital stay, which might reflect ischemic cardiovascular complications or acute myocarditis [1] [2] [3] . The main finding is that, in this cohort, in-hospital mortality was associated with older age, respiratory failure and elevated plasma levels of hs-TnI whereas cardiovascular comorbidities were not an independent risk factor at multivariable analysis. However, when age and respiratory failure at hospital admission were analyzed together with cardiac involvement in a multivariable analysis, only older age, a P/F ratio < 200 and elevated hs-TnI plasma levels were significant predictor of death and of the combined outcome. abstract: The correlation between myocardial injury and clinical outcome in COVID-19 patients is gaining attention in the literature. The aim of the present study was to evaluate the role of cardiac involvement and of respiratory failure in a cohort of COVID-19 patients hospitalized in an academic hospital in Lombardy, one of the most affected Italian (and worldwide) regions by the epidemic. The study included 405 consecutive patients with confirmed COVID-19 admitted to a medical ward from February 25th to March 31st, 2020. Follow-up of surviving patients ended either at hospital discharge or by July 30th, 2020. Myocardial injury was defined on the basis of the presence of blood levels of hs-TnI above the 99th percentile upper reference limit. Respiratory function was assessed as PaO(2)/FiO(2) (P/F) ratio. The primary end-point was death for any cause. During hospitalization, 124 patients died. Death rate increased from 7.9% in patients with normal hs-TnI plasma levels and no cardiac comorbidity to 61.5% in patients with elevated hs-TnI and cardiac involvement (p < 0.001). At multivariable analysis, older age, P/F ratio < 200 (both p < 0.001) and hs-TnI plasma levels were independent predictors of death. However, it must be emphasized that the median values of hs-TnI were within normal range in non-survivors. Cardiac involvement at presentation was associated with poor prognosis in COVID-19 patients, but, even in a population of COVID-19 patients who did not require invasive ventilation at hospital admission, mortality was mainly driven by older age and respiratory failure. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11739-020-02493-y) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32960429/ doi: 10.1007/s11739-020-02493-y id: cord-282483-0zsvhoog author: Ghisa, Matteo title: Reorganization of the Functional Gastrointestinal Disorders Unit during the SARS-CoV-2 Outbreak - Practical Recommendations date: 2020-07-10 words: 663.0 sentences: 42.0 pages: flesch: 46.0 cache: ./cache/cord-282483-0zsvhoog.txt txt: ./txt/cord-282483-0zsvhoog.txt summary: While endoscopy with biopsies and radiology remain our most effective weapons to identify or manage these disorders, procedures such as high-resolution manometry (HRM) and reflux monitoring are the most specialized techniques able to clarify unclear clinical scenarios and improve patients'' management. If an appointment is necessary, the day before the visit, health care professionals (HCPs) should call the patients to confirm it and to ask questions A rapid and functional reorganization of all the activities of a motility laboratory is mandatory to maintain as good as possible the standards of care, to reduce risks for both patients and healthcare personnel and to leave resources available to tackle this pandemic. However, considering that the efficacy of herd immunity is uncertain, a vaccine is not yet available and another wave of infections may arrive, COVID-19 could become a long-term problem and therefore it is necessary to permanently integrate these services in our way of providing medical care. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32690382/ doi: 10.1016/j.dld.2020.07.011 id: cord-292056-dtdyxhq4 author: Ghogawala, Zoher title: Editorial. COVID-19 and spinal surgery date: 2020-04-17 words: 1393.0 sentences: 74.0 pages: flesch: 51.0 cache: ./cache/cord-292056-dtdyxhq4.txt txt: ./txt/cord-292056-dtdyxhq4.txt summary: Second, the neurosurgery workflow was changed dramatically by the cancellation of elective surgery cases in order to increase hospital capacity for future COVID-19 patients. In most hospitals, all interventional spine procedures have been postponed to decrease patient exposure to COVID-19 and allow surgeons to focus their efforts on the treatment of patients who require urgent care. As more patients are admitted to hospitals with active COVID-19 infections, the risk of exposure for spinal surgeons increases. While caring for COVID-19-positive patients who might need emergency spine surgery, all personnel are required to wear N95 masks and no personnel other than the anesthesiologist are allowed in the OR for 30 minutes following intubation. As elective surgery has been reduced in hospitals, many spinal surgeons have been asked to participate in the care of medical patients. Having models to compensate physicians and hospitals for the effective use of telehealth will be one positive aspect of this crisis, which has provided many opportunities for new learning. abstract: nan url: https://doi.org/10.3171/2020.4.spine20468 doi: 10.3171/2020.4.spine20468 id: cord-005452-ouookpd8 author: Ghosh, K title: Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation date: 1999-04-19 words: 1154.0 sentences: 77.0 pages: flesch: 51.0 cache: ./cache/cord-005452-ouookpd8.txt txt: ./txt/cord-005452-ouookpd8.txt summary: title: Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation A 13-year-old patient with transfusion-dependent β thalassemia major developed acute regimen-related lung toxicity after the conditioning regimen but before allogeneic bone marrow transplantation. Advances in non-invasive ventilatory support may drastically improve the outlook of this subset of patients who otherwise have a grim prognosis Rabitsch et al 1 reported successful management of adult respiratory distress syndrome by non-invasive ventilatory support. On this intermittent CPAP the patient steadily improved, received his allogeneic marrow graft from his brother engrafting by day +9. It has also been suggested that this modality of management should be severely restricted 3 in allogeneic BMT patients, particularly during their first +100 days. Successful management of adult respiratory distress syndrome (ARDS) after high dose chemotherapy and peripheral blood progenitor cell rescue by non-invasive ventilatory support Non-invasive pressure support ventilation in patients with acute respiratory failure. abstract: A 13-year-old patient with transfusion-dependent β thalassemia major developed acute regimen-related lung toxicity after the conditioning regimen but before allogeneic bone marrow transplantation. He was successfully managed on non-invasive ventilatory support. Advances in non-invasive ventilatory support may drastically improve the outlook of this subset of patients who otherwise have a grim prognosis url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091807/ doi: 10.1038/sj.bmt.1701647 id: cord-322663-a58e6pp8 author: Giacomelli, Andrea title: 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study date: 2020-05-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Italy was the first European country hit by the COVID-19 pandemic and has the highest number of recorded COVID-19 deaths in Europe. This prospective cohort study of the correlates of the risk of death in COVID-19 patients was conducted at the Infectious Diseases and Intensive Care units of Luigi Sacco Hospital, Milan, Italy. The clinical characteristics of all the COVID-19 patients hospitalised in the early days of the epidemic (21 February -19 March 2020) were recorded upon admission, and the time-dependent probability of death was evaluated using the Kaplan-Meier method (censored as of 20 April 2020). Cox proportional hazard models were used to assess the factors independently associated with the risk of death. Forty-eight (20.6%) of the 233 patients followed up for a median of 40 days (interquartile range 33-47) died during the follow-up. Most were males (69.1%) and their median age was 61 years (IQR 50-72). The time-dependent probability of death was 19.7% (95% CI 14.6-24.9%) 30 days after hospital admission. Age (adjusted hazard ratio [aHR] 2.08, 95% CI 1.48-2.92 per ten years more) and obesity (aHR 3.04, 95% CI 1.42-6.49) were independently associated with an increased risk of death, which was also associated with critical disease (aHR 8.26, 95% CI 1.41-48.29), C-reactive protein levels (aHR 1.17, 95% CI 1.02-1.35 per 50 mg/L more) and creatinine kinase levels above 185 U/L (aHR 2.58, 95% CI 1.37-4.87) upon admission. Case-fatality rate of patients hospitalized with COVID-19 in the early days of the Italian epidemic was about 20%. Our study adds evidence to the notion that older age, obesity and more advanced illness are factors associated to an increased risk of death among patients hospitalized with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32446978/ doi: 10.1016/j.phrs.2020.104931 id: cord-339436-0k73tlna author: Giagulli, Vito Angelo title: Worse progression of COVID‐19 in men: Is Testosterone a key factor? date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The novel Severe Acute Respiratory Syndrome Coronavirus (SARS‐CoV‐2) disease 2019 (COVID‐19) seems to have a worse clinical course among infected men compared to women, thus, highlighting concerns about gender predisposition to serious prognosis. Therefore, androgens, particularly testosterone (T), could be suspected as playing a critical role in driving this excess of risk. However, gonadal function in critically ill men is actually unknown, mainly because serum T concentration is not routinely measured in clinical practice, even more in this clinical context. OBJECTIVE: To overview on possible mechanisms by which serum T levels could affect the progression of COVID‐19 in men. METHODS: Authors searched PubMed/Medline, Web of Science, EMBASE, Cochrane Library, Google, and Institutional websites for medical subheading terms and free text words referred to “SARS‐CoV‐2”, “COVID‐19”, “testosterone”, “male hypogonadism”, “gender” “immune system”, “obesity”, “thrombosis” until May 19(th) 2020. RESULTS: T, co‐regulating the expression of angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in host cells, may facilitate SARS‐CoV‐2 internalization. Instead, low serum T levels may predispose to endothelial dysfunction, thrombosis and defective immune response, leading to both impaired viral clearance and systemic inflammation. Obesity, one of the leading causes of severe prognosis in infected patients, is strictly associated with functional hypogonadism, and may consistently strengthen the aforementioned alterations, ultimately predisposing to serious respiratory and systemic consequences. DISCUSSION AND CONCLUSION: T in comparison to estrogen may predispose men to a widespread COVID‐19 infection. Low serum levels of T, which should be supposed to characterize the hormonal milieu in seriously ill individuals, may predispose men, especially aged men, to poor prognosis or death. Further studies are needed to confirm these pathophysiological assumptions and to promptly identify adequate therapeutic strategies. url: https://www.ncbi.nlm.nih.gov/pubmed/32524732/ doi: 10.1111/andr.12836 id: cord-000891-5r2in1gw author: Giannella, Maddalena title: Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? date: 2012-06-14 words: 4115.0 sentences: 233.0 pages: flesch: 44.0 cache: ./cache/cord-000891-5r2in1gw.txt txt: ./txt/cord-000891-5r2in1gw.txt summary: Suspected and unsuspected cases were compared, and significant differences were found for age (53 versus 69 median years), severe respiratory failure (68.8% versus 20%), surgery (6.3% versus 60%), median days of ICU stay before diagnosis (1 versus 4), nosocomial infection (18.8% versus 66.7%), cough (93.8% versus 53.3%), localized infiltrate on chest radiograph (6.3% versus 40%), median days to antiviral treatment (2 versus 9), pneumonia (93.8% versus 53.3%), and acute respiratory distress syndrome (75% versus 26.7%). The variables recorded were age, sex, classification of the severity of underlying conditions according to the Charlson comorbidity index [6] , type of ICU, date and cause of ICU admission, APACHE II score [7] on admission to the ICU, date of onset of influenza symptoms, clinical manifestations and radiologic findings at diagnosis, date of TA sample collection, other samples tested for influenza and result, date of initiation of antiviral treatment, complications (septic shock, acute respiratory distress syndrome (ARDS)), outcome including mortality within 30 days after influenza diagnosis, and length of ICU and hospital stay. abstract: INTRODUCTION: Influenza is easily overlooked in intensive care units (ICUs), particularly in patients with alternative causes of respiratory failure or in those who acquire influenza during their ICU stay. METHODS: We performed a prospective study of patients admitted to three adult ICUs of our hospital from December 2010 to February 2011. All tracheal aspirate (TA) samples sent to the microbiology department were systematically screened for influenza. We defined influenza as unsuspected if testing was not requested and the patient was not receiving empirical antiviral therapy after sample collection. RESULTS: We received TA samples from 105 patients. Influenza was detected in 31 patients and was classified as unsuspected in 15 (48.4%) patients, and as hospital acquired in 13 (42%) patients. Suspected and unsuspected cases were compared, and significant differences were found for age (53 versus 69 median years), severe respiratory failure (68.8% versus 20%), surgery (6.3% versus 60%), median days of ICU stay before diagnosis (1 versus 4), nosocomial infection (18.8% versus 66.7%), cough (93.8% versus 53.3%), localized infiltrate on chest radiograph (6.3% versus 40%), median days to antiviral treatment (2 versus 9), pneumonia (93.8% versus 53.3%), and acute respiratory distress syndrome (75% versus 26.7%). Multivariate analysis showed admission to the surgical ICU (odds ratio (OR), 37.1; 95% confidence interval (CI), 2.1 to 666.6; P = 0.01) and localized infiltrate on chest radiograph (OR, 27.8; 95% CI, 1.3 to 584.1; P = 0.03) to be independent risk factors for unsuspected influenza. Overall mortality at 30 days was 29%. ICU admission for severe respiratory failure was an independent risk factor for poor outcome. CONCLUSION: During the influenza season, almost one third of critical patients with suspected lower respiratory tract infection had influenza, and in 48.4%, the influenza was unsuspected. Lower respiratory samples from adult ICUs should be systematically screened for influenza during seasonal epidemics. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580661/ doi: 10.1186/cc11387 id: cord-325307-agaau27o author: Giavedoni, Priscila title: Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity date: 2020-10-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Data on the clinical patterns and histopathology of SARS-CoV-2 related skin lesions, as well as on their relationship with the severity of COVID-19 are limited. Methods and Materials: Retrospective analysis of a prospectively collected cohort of patients with SARS-CoV-2 infection in a teaching hospital in Barcelona, Spain, from 1 April to 1 May 2020. Clinical, microbiological and therapeutic characteristics, clinicopathological patterns of skin lesions, and direct immunofluorescence and immunohistochemical findings in skin biopsies were analyzed. Results: Fifty-eight out of the 2761 patients (2.1%) either consulting to the emergency room or admitted to the hospital for COVID-19 suspicion during the study period presented COVID-19 related skin lesions. Cutaneous lesions could be categorized into six patterns represented by the acronym “GROUCH”: Generalized maculo-papular (20.7%), Grover’s disease and other papulo-vesicular eruptions (13.8%), livedo Reticularis (6.9%), Other eruptions (22.4%), Urticarial (6.9%), and CHilblain-like (29.3%). Skin biopsies were performed in 72.4%, including direct immunofluorescence in 71.4% and immunohistochemistry in 28.6%. Patients with chilblain-like lesions exhibited a characteristic histology and were significantly younger and presented lower rates of systemic symptoms, radiological lung infiltrates and analytical abnormalities, and hospital and ICU admission compared to the rest of patients. Conclusion: Cutaneous lesions in patients with COVID-19 appear to be relatively rare and varied. Patients with chilblain-like lesions have a characteristic clinicopathological pattern and a less severe presentation of COVID-19. url: https://doi.org/10.3390/jcm9103261 doi: 10.3390/jcm9103261 id: cord-280360-rh37d5wc author: Gibson, David S. title: Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease date: 2009-05-02 words: 8297.0 sentences: 388.0 pages: flesch: 41.0 cache: ./cache/cord-280360-rh37d5wc.txt txt: ./txt/cord-280360-rh37d5wc.txt summary: title: Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis -Proteomic patterns of joint inflammation in early stage disease 1 We initially performed a study of the proteins expressed within synovial fluid and plasma in early JIA in order to discover novel biomarkers which distinguish between local and systemic components of joint inflammation in arthritis. The simultaneous analysis of individual paired plasma and synovial fluids from ten patients ( Table 1 , study group A) was used to initially isolate joint-specific protein expression profiles, without introducing bias from inter-individual differences. A number of proteins with consistent synovial and plasma ''specific'' expression patterns are highlighted and quantified to demonstrate the ability to reliably differentiate molecular fingerprints of local and systemic disease across patient groups by this gel based approach. abstract: Synovial fluid is a potential source of novel biomarkers for many arthritic disorders involving joint inflammation, including juvenile idiopathic arthritis. We first compared the distinctive protein ‘fingerprints’ of local inflammation in synovial fluid with systemic profiles within matched plasma samples. The synovial fluid proteome at the time of joint inflammation was then evaluated across clinical subgroups to identify early disease associated proteins. We measured the synovial fluid and plasma proteomes using the two-dimensional fluorescence difference gel electrophoresis approach. Image analysis software was used to highlight the expression levels of joint and subgroup associated proteins across the study cohort (n = 32). A defined subset of 30 proteins had statistically significant differences (p < 0.05) between sample types such that synovial fluid could be differentiated from plasma. Furthermore distinctive synovial proteome expression patterns segregate patient subgroups. Protein expression patterns localized in the chronically inflamed joint therefore have the potential to identify patients more likely to suffer disease which will spread from a single joint to multiple joints. The proteins identified could act as criteria to prevent disease extension by more aggressive therapeutic intervention directed at an earlier stage than is currently possible. url: https://www.ncbi.nlm.nih.gov/pubmed/19367684/ doi: 10.1016/j.jprot.2009.01.022 id: cord-311848-8n9ee57a author: Giesen, Nicola title: Evidence-based Management of COVID-19 in Cancer Patients – Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) date: 2020-09-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Since its first detection in China in late 2019 the novel coronavirus SARS-CoV-2 and the associated infectious disease COVID-19 continue to have a major impact on global health care and clinical practice. Cancer patients, in particular those with haematological malignancies, seem to be at an increased risk for a severe course of infection. Deliberations to avoid or defer potentially immunosuppressive therapies in these patients need to be balanced against the overarching goal of providing optimal antineoplastic treatment. This poses a unique challenge to treating physicians. This guideline provides evidence-based recommendations regarding prevention, diagnostics and treatment of SARS-CoV-2 infection and COVID-19 as well as strategies towards safe antineoplastic care during the COVID-19 pandemic. It was prepared by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) by critically reviewing the currently available data on SARS-CoV-2 and COVID-19 in cancer patients applying evidence-based medicine criteria. url: https://www.sciencedirect.com/science/article/pii/S0959804920304937?v=s5 doi: 10.1016/j.ejca.2020.09.009 id: cord-266478-642m488a author: Gino, Bruno title: Automated Inflating Resuscitator (AIR): Design and Development of a 3D-Printed Ventilator Prototype and Corresponding Simulation Scenario Based on the Management of a Critical COVID-19 Patient date: 2020-07-11 words: 5438.0 sentences: 334.0 pages: flesch: 49.0 cache: ./cache/cord-266478-642m488a.txt txt: ./txt/cord-266478-642m488a.txt summary: title: Automated Inflating Resuscitator (AIR): Design and Development of a 3D-Printed Ventilator Prototype and Corresponding Simulation Scenario Based on the Management of a Critical COVID-19 Patient The aim of this technical report is twofold: first, to describe the design and manufacturing process of the automated inflating resuscitator (AIR), a 3D-printed ventilator training device which operates on the principle of pushing a bag valve mask; second, to present a simulation scenario that can be used for training health professionals how to use this and similar, low-cost, 3D-printed ventilators in the context of ventilator shortages caused by COVID-19. In addition to the description of the ventilator, we also present a simulation case using AIR to train safety, operational ability, crisis resource management, and communication skills. If there is a limited supply of participants, the paramedics team can only be reported by the facilitators, as the main objective of this simulation is training with the use of AIR and care involving a patient with COVID-19. abstract: Recent surges in COVID-19 cases have generated an urgent global demand for ventilators. This demand has led to the development of numerous low-cost ventilation devices, but there has been less emphasis on training health professionals to use these new devices safely. The aim of this technical report is twofold: first, to describe the design and manufacturing process of the automated inflating resuscitator (AIR), a 3D-printed ventilator training device which operates on the principle of pushing a bag valve mask; second, to present a simulation scenario that can be used for training health professionals how to use this and similar, low-cost, 3D-printed ventilators in the context of ventilator shortages caused by COVID-19. To this end, the AIR was designed in an expedient manner in accordance with basic functionality established by the Medicines and Healthcare Products Regulatory Agency (United Kingdom) for provisional clinical use in light of COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32789074/ doi: 10.7759/cureus.9134 id: cord-291176-evb6yt0r author: Giorgi Rossi, Paolo title: Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy date: 2020-08-27 words: 4559.0 sentences: 213.0 pages: flesch: 46.0 cache: ./cache/cord-291176-evb6yt0r.txt txt: ./txt/cord-291176-evb6yt0r.txt summary: In this report, based on the cohort of all residents in the province of Reggio Emilia who were SARS-CoV-2-positive at nasal and pharyngeal swab and with symptoms (COVID-19 cases) since the inception of the epidemic, we describe patient characteristics and explore their role as putative prognostic factors in predicting the occurrence of hospital admission or death. We considered the following patient characteristics: age, sex, place of birth (Italy or abroad), time span (in days) from symptom onset to diagnosis/ hospitalization, and comorbidities, whose prognostic role was explored both singly (chronic obstructive pulmonary disease, arrhythmia, diabetes, coronary heart disease, heart failure, vascular diseases, obesity) and by computing the Charlson Comorbidity Index, which provides an overall measure of an individual patient''s complexity [12] . While in this study we focused on the risk of hospitalization and death in a cohort of COVID-19 patients diagnosed during the epidemic in Northern Italy, it also provided us with the opportunity to describe the pattern of distribution of the disease in the whole population. abstract: This is a population-based prospective cohort study on archive data describing the age- and sex-specific prevalence of COVID-19 and its prognostic factors. All 2653 symptomatic patients tested positive for SARS-CoV-2 from February 27 to April 2, 2020 in the Reggio Emilia province, Italy, were included. COVID-19 cumulative incidence, hospitalization and death rates, and adjusted hazard ratios (HR) with 95% confidence interval (95% CI) were calculated according to sociodemographic and clinical characteristics. Females had higher prevalence of infection than males below age 50 (2.61 vs. 1.84 ‰), but lower in older ages (16.49 vs. 20.86 ‰ over age 80). Case fatality rate reached 20.7% in cases with more than 4 weeks follow up. After adjusting for age and comorbidities, men had a higher risk of hospitalization (HR 1.4 95% CI 1.2 to 1.6) and of death (HR 1.6, 95% CI 1.2 to 2.1). Patients over age 80 compared to age < 50 had HR 7.1 (95% CI 5.4 to 9.3) and HR 27.8 (95% CI 12.5 to 61.7) for hospitalization and death, respectively. Immigrants had a higher risk of hospitalization (HR 1.3, 95% CI 0.99 to 1.81) than Italians and a similar risk of death. Risk of hospitalization and of death were higher in patients with heart failure, arrhythmia, dementia, coronary heart disease, diabetes, and hypertension, while COPD increased the risk of hospitalization (HR 1.9, 95% CI 1.4 to 2.5) but not of death (HR 1.1, 95% CI 0.7 to 1.7). Previous use of ACE inhibitors had no effect on risk of death (HR 0.97, 95% CI 0.69 to 1.34). Identified susceptible populations and fragile patients should be considered when setting priorities in public health planning and clinical decision making. url: https://doi.org/10.1371/journal.pone.0238281 doi: 10.1371/journal.pone.0238281 id: cord-324245-cfiekxr4 author: Giorgi-Pierfranceschi, Matteo title: Prevalence of asymptomatic deep vein thrombosis in patients hospitalized with SARS-CoV-2 pneumonia: a cross-sectional study date: 2020-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The association between coronavirus disease 2019 (COVID-19) pneumonia and venous thrombotic disorders is still unclear. We assessed the association between COVID-19 infection-related pneumonia and proximal deep-vein thrombosis (DVT) in a cohort of patients admitted to our hospital during the European outbreak in the front line of Cremona, Lombardy. In a single-center cross-sectional study, all patients hospitalized for more than 5 days in Internal Medicine Department with confirmed COVID-19 pneumonia received 2-point compressive ultrasound assessment (CUS) of the leg vein system during a single day. Ninety-four percent of patients received enoxaparin as standard pharmacological prophylaxis for venous thromboembolism. The presence of DVT was defined as incompressibility of popliteal or common femoral vein. Out of 121 patients with COVID-19 pneumonia (mean age 71.8, 66.3% males) hospitalized on March 31st, 70 stayed in hospital for over 5 days and 66 of them underwent CUS of deep venous system of the legs. The presence of asymptomatic DVT was found in 9 patients (13.6%). No symptomatic DVT was found. Patients with DVT showed mean age = 75.7 years, mean D-dimer levels = 4.02 ng/ml and all of them received enoxaparin for thromboprophylaxis, except one. Computed tomography pulmonary angiogram confirmed pulmonary embolism in five patients. One every seven patients with COVID-19-related pneumonia, hospitalized for more than 5 days, had asymptomatic proximal DVT and half of them had confirmed PE despite standard pharmacological thromboprophylaxis. This observational study suggests the need of an active surveillance through CUS in patients hospitalized with acute SARS-COV-2 and underline the need of a more intense thromboprophylaxis. url: https://www.ncbi.nlm.nih.gov/pubmed/32840805/ doi: 10.1007/s11739-020-02472-3 id: cord-313860-mzs3ya0s author: Giulietti, Federico title: Pharmacological Approach to Smoking Cessation: An Updated Review for Daily Clinical Practice date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Tobacco use is one of the major public health concerns and it is the most preventable cause of morbidity and mortality worldwide. Smoking cessation reduces subsequent cardiovascular events and mortality. Smoking is a real chronic disorder characterized by the development of an addiction status mainly due to nicotine. This condition makes the smokers generally unable to quit smoking without help. Different strategies are available to treat smoking dependence that include both non-pharmacological (behavioral counselling) and pharmacological therapies. Currently, it is well accepted that smoking cessation drugs are effective and safe in real-world settings. Nicotine replacement therapy (NRT), varenicline, bupropion and cytisine are the main pharmacological strategies available for smoking cessation. Their efficacy and safety have been proved even in patients with chronic cardiovascular disease. Each of these drugs has peculiar characteristics and the clinician should customize the smoking cessation strategy based on currently available scientific evidence and patient's preference, paying particular attention to those patients having specific cardiovascular and psychiatric comorbidities. The present document aims to summarize the current viable pharmacological strategies for smoking cessation, also discussing the controversial issue regarding the use of alternative tobacco products, in order to provide useful practical indications to all physicians, mainly to those involved in cardiovascular prevention. url: https://doi.org/10.1007/s40292-020-00396-9 doi: 10.1007/s40292-020-00396-9 id: cord-351531-wo1ggmmn author: Giustiniano, Enrico title: Trans-thoracic Echocardiography in Prone Positioning COVID-19 Patients: a Small Case Series date: 2020-09-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: During SARS-CoV-2 pandemic, several subjects were treated in our intensive care unit (ICU) because of acute respiratory failure following COVID-19 pneumonia. Most of them required mechanical ventilation and someone in prone position (PP) too, because of acute respiratory distress syndrome (ARDS). During PP, trans-esophageal echocardiography (TEE) is not always easy, mainly due to the forced position of the neck of the patient. Moreover, during a pandemic, given the great number of patients needing treatment, TEE probes and monitoring devices are not widely available. Then, trans-thoracic echocardiography (TTE) plays a crucial role as it is non-invasive, repeatable, and available every time it is needed. Moreover, it can be safely performed also in prone position (TTEp). According to in-hospital protocol, TTEp was performed using the apical-four-chamber (A-4-C) view in 8 patients. We temporarily deflated the lower thoracic section of the air-mattress to place the probe between the mattress surface and the thorax of the patient. We collected both TEE and hemodynamics data. The main result of our retrospective analysis is that TTE can be performed in patients in prone positioning and is reliable and repeatable; the single apical-four-chamber view provides sufficient data to evaluate the cardiac performance in case of scarce availability of hemodynamic monitoring devices, like in a pandemic setting. TTE may be a helpful tool for cardiac performance evaluation and diagnosis not only in supine or anterolateral positioning like in echocardiographic lab, but also in subjects admitted to ICU due to ARDS needing of mechanical ventilation in prone positioning. url: https://www.ncbi.nlm.nih.gov/pubmed/32954211/ doi: 10.1007/s42399-020-00516-5 id: cord-282043-cs1oyohu author: Giustino, Gennaro title: Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC Focus Seminar date: 2020-10-27 words: 1923.0 sentences: 114.0 pages: flesch: 27.0 cache: ./cache/cord-282043-cs1oyohu.txt txt: ./txt/cord-282043-cs1oyohu.txt summary: Both direct viral infection and indirect injury resulting from inflammation, endothelial activation, and microvascular thrombosis occur in the context of coronavirus disease 2019. Although originally believed to be a syndrome characterized by acute lung injury, respiratory failure, and death, it is now apparent that severe coronavirus disease 2019 (COVID-19) is further characterized by exuberant cytokinemia, with resultant endothelial inflammation, microvascular thrombosis, and multiorgan failure (2) . Myocardial injury can be detected in w25% of hospitalized patients with COVID-19 and is associated with an increased risk of mortality. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Acute myocardial injury in patients hospitalized with COVID-19 infection: a review Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 abstract: The cardiovascular system is affected broadly by severe acute respiratory syndrome coronavirus 2 infection. Both direct viral infection and indirect injury resulting from inflammation, endothelial activation, and microvascular thrombosis occur in the context of coronavirus disease 2019. What determines the extent of cardiovascular injury is the amount of viral inoculum, the magnitude of the host immune response, and the presence of co-morbidities. Myocardial injury occurs in approximately one-quarter of hospitalized patients and is associated with a greater need for mechanical ventilator support and higher hospital mortality. The central pathophysiology underlying cardiovascular injury is the interplay between virus binding to the angiotensin-converting enzyme 2 receptor and the impact this action has on the renin-angiotensin system, the body’s innate immune response, and the vascular response to cytokine production. The purpose of this review was to describe the mechanisms underlying cardiovascular injury, including that of thromboembolic disease and arrhythmia, and to discuss their clinical sequelae. url: https://www.sciencedirect.com/science/article/pii/S0735109720364949 doi: 10.1016/j.jacc.2020.08.059 id: cord-340984-blkhfhe2 author: Gklinos, Panagiotis title: Neurological manifestations of COVID-19: a review of what we know so far date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID‐19) has become a pandemic disease globally. While it mostly presents with respiratory symptoms, it has already been found that it could manifest with a series of neurological symptoms as well, either at presentation or during the course of the disease. Symptoms vary from non-specific such as headache or dizziness to more specific such as convulsions and cerebrovascular disease (CVD). This study aims to give an overview of the neurological manifestations of COVID-19 and discuss the potential pathogenetic mechanisms of central nervous system (CNS) involvement. Clinicians and especially internists, neurologists, and infectious disease specialists should be aware of these symptoms and able to recognize them early. Prompt diagnosis and immediate management of the neurological manifestations of the novel coronavirus will not only improve the prognosis of COVID-19 patients but will also prevent the dissemination of the disease due to misdiagnosed cases. url: https://www.ncbi.nlm.nih.gov/pubmed/32458197/ doi: 10.1007/s00415-020-09939-5 id: cord-017581-6lubp7io author: Glass, Daniel M. title: Respiratory Diseases of Pregnancy date: 2019-07-24 words: 2515.0 sentences: 163.0 pages: flesch: 43.0 cache: ./cache/cord-017581-6lubp7io.txt txt: ./txt/cord-017581-6lubp7io.txt summary: Pregnant patients can suffer from the same respiratory diseases as the general population in addition to unique syndromes of pregnancy (such as pre-eclampsia and tocolytic induced pulmonary edema, and pregnancy induced cardiomyopathy). Low pulmonary reserves that arise from reductions in functional residual capacity (caused by the gravid uterus and changes in the chest wall morphology) [1] and increased oxygen consumption make pregnant women develop hypoxemia more rapidly during apnea [4] . The most common causes of non-cardiogenic acute pulmonary edema in pregnancy are, fluid overload, preeclampsia, tocolytic agents, sepsis, trauma or following aspiration of gastric contents [6, 7] . A partial pressure of carbon dioxide within the normal range of 36-40 on an arterial blood gas can be an early sign of imminent respiratory failure in the gravid patient. Some of the risk factors for pneumonia in pregnancy include anemia, asthma, antepartum corticosteroids given to enhance fetal lung maturity, and the use of tocolytic agents to induce labor [27] . abstract: Pregnant patients can suffer from the same respiratory diseases as the general population in addition to unique syndromes of pregnancy (such as pre-eclampsia and tocolytic induced pulmonary edema, and pregnancy induced cardiomyopathy). Pregnancy by itself may add certain challenges such as difficult intubation. The critically ill pregnant patient requires a multidisciplinary approach and early inclusion of obstetrical expertise is paramount in managing these patients especially in the third trimester. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122174/ doi: 10.1007/978-3-030-26710-0_99 id: cord-009967-fyqc5bat author: Gleckman, Richard title: Cost‐Effective Antibiotic Prescribing date: 2012-01-24 words: 5938.0 sentences: 307.0 pages: flesch: 30.0 cache: ./cache/cord-009967-fyqc5bat.txt txt: ./txt/cord-009967-fyqc5bat.txt summary: Recent studies have confirmed the efficacy and reduced expense of oral antibiotics prescribed for selected children with osteomyelitis and septic arthritis.1"22 In 1973, it was reported that favorable results ensued when oral antibiotic therapy was prescribed for hospitalized patients with serious infectionsz3 Fourteen patients with osteomyelitis were treated successfully with oral cephalexin after they had received a short course of parenteral cephaloridine. Adults with disseminated gonococcal infection can be effectively treated with a one week program consisting initially of 2 million units of penicillin G administered every 4 hours followed by oral ampicillin or amoxicillin prescribed as 500 mg four times daily.34,35 Hospitalization is usually recommended to establish the diagnosis of disseminated gonococcal disease since misdiagnosis occurs not infrequently with this disorder.33 Selected patients can complete the oral regimens in an outpatient setting or, alternatively, they can be treated entirely without ho~pitalization.~~ Acceptable oral regimens consist of giving amoxicillin (500 mg four times daily), tetracycline (500 mg four times daily), or erythromycin (500 mg four times daily) for at least 7 days. abstract: Antibiotics are often misused, resulting in a high frequency of adverse effects, emergence of drug‐resistant organisms, and excessive costs. The high cost of antibiotics is currently receiving the greatest attention. Considerable cost savings can be achieved by appropriate prescribing of antibiotics for patients receiving these drugs prophylactically as well as for those with established infections. This article cites specific examples of how cost‐effective antibiotic prescribing practices can realize substantial cost savings without any diminished quality in patient care. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167648/ doi: 10.1002/j.1875-9114.1983.tb03264.x id: cord-011533-im78xwl8 author: Gloude, Nicholas J. title: Thinking Beyond HLH: Clinical Features of Patients with Concurrent Presentation of Hemophagocytic Lymphohistiocytosis and Thrombotic Microangiopathy date: 2020-05-23 words: 4879.0 sentences: 262.0 pages: flesch: 37.0 cache: ./cache/cord-011533-im78xwl8.txt txt: ./txt/cord-011533-im78xwl8.txt summary: MODS was diagnosed when a patient had symptoms of HLH/TMA and dysfunction of two or more organ systems: renal failure requiring renal replacement therapy (RRT) or cystatin C glomerular filtration rate (GFR) < 50 mL/min, invasive or non-invasive positive pressure ventilator support for > 24 h, diagnosis of pulmonary hypertension (as determined by echocardiogram and cardiology consultation), serositis (pleural or pericardial effusions), severe hypertension requiring either ≥ 2 medications or continuous infusion of an antihypertensive for > 12 h to maintain blood pressure < 99% for age, CNS symptoms (seizures, bleeding, posterior reversible encephalopathy syndrome (PRES), or altered mental status), or gastrointestinal symptoms (ileus and/or bleeding) [20] [21] [22] [23] [24] . We observed a high incidence of clinically significant complement-mediated thrombotic microangiopathy (TMA) associated with multi-organ injury in children and young adults with a diagnosis of HLH. abstract: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune system activation driven mainly by high levels of interferon gamma. The clinical presentation of HLH can have considerable overlap with other inflammatory conditions. We present a cohort of patients with therapy refractory HLH referred to our center who were found to have a simultaneous presentation of complement-mediated thrombotic microangiopathy (TMA). Twenty-three patients had therapy refractory HLH (13 primary, 4 EVB-HLH, 6 HLH without known trigger). Sixteen (69.6%) met high-risk TMA criteria. Renal failure requiring renal replacement therapy, severe hypertension, serositis, and gastrointestinal bleeding were documented only in patients with HLH who had concomitant complement-mediated TMA. Patients with HLH and without TMA required ventilator support mainly due to CNS symptoms, while those with HLH and TMA had respiratory failure predominantly associated with pulmonary hypertension, a known presentation of pulmonary TMA. Ten patients received eculizumab for complement-mediated TMA management while being treated for HLH. All patients who received the complement blocker eculizumab in addition to the interferon gamma blocker emapalumab had complete resolution of their TMA and survived. Our observations suggest co-activation of both interferon and complement pathways as a potential culprit in the evolution of thrombotic microangiopathy in patients with inflammatory disorders like refractory HLH and may offer novel therapeutic approaches for these critically ill patients. TMA should be considered in children with HLH and multi-organ failure, as an early institution of a brief course of complement blocking therapy in addition to HLH-targeted therapy may improve clinical outcomes in these patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10875-020-00789-4) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245179/ doi: 10.1007/s10875-020-00789-4 id: cord-311341-7ox30d2u author: Goenka, Anuj title: Implementation of Telehealth in Radiation Oncology: Rapid Integration During COVID-19 and its Future Role in our Practice date: 2020-10-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The widespread coronavirus disease 2019 (COVID-19) has resulted in significant changes in care delivery among radiation oncology practices and demanded the rapid incorporation of telehealth. However, the impact of a large-scale transition to telehealth in radiation oncology on patient access to care and the viability of care delivery are largely unknown. In this manuscript, we review our implementation and report data on patient access to care and billing implications. As telehealth is likely to continue after COVID-19, we propose a radiation oncology-specific algorithm for telehealth. MATERIAL AND METHODS: In March 2020, our department began to use telehealth for all new consults, post-treatment encounters, and follow-up appointments. Billable encounters from January to April 2020 were reviewed and categorized into one of the following visit types: in-person, telephonic, or two-way audio-video. Logistic regression models tested whether visit type differed by patient age, income, or provider. RESULTS: There was a 35% decrease in billable activity from January to April. In-person visits decreased from 100% to 21%. Sixty percent of telehealth appointments in April were performed with two-way audio-video, and 40% by telephonic only. In-person consultation visits were associated with higher billing codes compared to two-way audio-video telehealth visits (p<0.01). No difference was seen for follow-up visits. Univariate and multivariable analysis identified that older patient age was associated with reduced likelihood of two-way audio-video encounters (p<0.01). The physician conducting the telehealth appointment was also associated with the type of visit performed (p<0.01). Patient income was not associated with the type of telehealth visit. CONCLUSIONS: Since the onset of COVID-19 pandemic, we were able to move the majority of patient visits to telehealth but observed inconsistent utilization of the audio-video telehealth platform. We present guidelines and quality metrics for incorporating telehealth in radiation oncology practice, based on type of encounter and disease subsite. url: https://www.ncbi.nlm.nih.gov/pubmed/33073060/ doi: 10.1016/j.adro.2020.09.015 id: cord-296676-2anl2agl author: Goldberg, Michael F. title: Neuroradiologic manifestations of COVID-19: what the emergency radiologist needs to know date: 2020-08-21 words: 4158.0 sentences: 213.0 pages: flesch: 43.0 cache: ./cache/cord-296676-2anl2agl.txt txt: ./txt/cord-296676-2anl2agl.txt summary: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global pandemic with a wide spectrum of clinical signs and symptoms. These neurologic manifestations were more common in severely affected patients, tended to occur early in the disease course, and could be the initial, presenting clinical evidence of COVID-19 [4] . Lastly, the authors note that ECMO alone (in the absence of SARS-CoV-2 infection) is a risk factor for intracranial hemorrhage, further limiting the generalizability of this small case series. Regardless, prior studies that evaluated neuroimaging findings of patients infected with other members of the Betacoronavirus genus have also demonstrated significant abnormalities, including intracranial hemorrhage and evidence of acute disseminated encephalomyelitis (ADEM), which could represent sequelae of inflammatory response and/or direct CNS infection [50, 51] . On behalf of the CoCo Neurosciences study group (2020) Retrospective observational study of brain magnetic resonance imaging findings in patients with acute SARS-CoV-2 infection and neurological manifestations abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global pandemic with a wide spectrum of clinical signs and symptoms. Neurologic manifestations are relatively common, with severe cases often demonstrating striking findings on neuroimaging. Because the neuroradiologic findings may be the first evidence of COVID-19, the emergency radiologist has a critical role to play in not only the detection and management of the disease but also in the safety of other patients and hospital staff. Therefore, radiologists, especially those who specialize in emergency radiology, need to be aware of the neuroradiologic manifestations of COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32822060/ doi: 10.1007/s10140-020-01840-y id: cord-253746-15w4gquq author: Goldman, Michel title: Reflections on the Collaborative Fight Against COVID-19 date: 2020-09-17 words: 1633.0 sentences: 75.0 pages: flesch: 41.0 cache: ./cache/cord-253746-15w4gquq.txt txt: ./txt/cord-253746-15w4gquq.txt summary: As therapeutic interventions in the early phase of the disease are attracting more and more interest, we argue that now is the time to involve patients'' organizations in the design of clinical protocols in order to define the most relevant end-points and assess the risk-benefit balance of new therapies. In this editorial perspective, we argue that patients'' voice will be essential to ensure uptake in the wider public of new therapies and vaccines resulting from these initiatives. Therefore, it is essential that trials are designed to include sufficient numbers of patients within the period of time during which the pandemic is expected to be active. Furthermore, patient reported outcomes are essential to assess the impact of therapeutic interventions on the long-term consequences of COVID-19 (13) . It is therefore important that patient organizations are involved early on in the design of clinical trials. abstract: Clinical trials to identify efficient treatments against COVID-19 flourish worldwide without much attention to patients' voice so far. As therapeutic interventions in the early phase of the disease are attracting more and more interest, we argue that now is the time to involve patients' organizations in the design of clinical protocols in order to define the most relevant end-points and assess the risk-benefit balance of new therapies. url: https://doi.org/10.3389/fmed.2020.00565 doi: 10.3389/fmed.2020.00565 id: cord-355296-46jf56nc author: Goldstein, David P. title: Tracheoesophageal voice prosthesis management in laryngectomy patients during the COVID-19 pandemic date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: With the COVID-19 pandemic, there has been significant changes and challenges in the management of oncology patients. One of the major strategies to reduce transmission of the virus between patients and healthcare workers is deferral of follow-up visits. However, deferral may not be possible in total laryngectomy patients. Urgent procedures may be necessary to prevent complications related to ill-fitting tracheoesophageal puncture (TEP) voice prostheses, such as aspiration or loss of voicing. In this paper, we describe the Princess Margaret Cancer Center’s approach to managing this unique patient population. url: https://doi.org/10.1186/s40463-020-00456-z doi: 10.1186/s40463-020-00456-z id: cord-019968-o5bdb37q author: Goldwater, Paul N. title: Gastroenteritis in Auckland: An aetiological and clinical study date: 2005-04-14 words: 3584.0 sentences: 214.0 pages: flesch: 51.0 cache: ./cache/cord-019968-o5bdb37q.txt txt: ./txt/cord-019968-o5bdb37q.txt summary: Faecal specimens from 60 patients (under six years old), most of whom were Maoris and Pacific Islanders admitted to Auckland Hospital with gastroenteritis during the months of June and July 1977, were examined for the presence of faecal viruses, bacterial pathogens and parasites. Non-agglutinable rotavirus, presumably a different serotype, was seen in both gastroenteritis and control patients. In June and July, 1977 , patients admitted to Auckland Hospital with gastroenteritis were studied to determine the relative isolation rates of (1) rotavirus, (2) other viruses identifiable by electronmicroscopy of stools, (3) enterotoxigenic Esch. Three of 18 (17 per cent) control stools contained rotavirus (one of which had non-agglutinable virus detectable on IEM). From Table III it is seen that enterotoxigenic isolates were found in both groups of gastroenteritis patients and also in non-diarrhoeal controls. Rotavirus-like particles that failed to agglutinate on IEM were seen in two gastroenteritis patients'' stools and in one control patient''s stool. abstract: Faecal specimens from 60 patients (under six years old), most of whom were Maoris and Pacific Islanders admitted to Auckland Hospital with gastroenteritis during the months of June and July 1977, were examined for the presence of faecal viruses, bacterial pathogens and parasites. Faecal specimens from 18 non-diarrhoeal control patients were also examined, of which three contained rotavirus. Forty-three (72 per cent) gastroenteritis patients had rotavirus detectable in stools by electron microscopy or immune electron microscopy. Of the remainder, 17 patients were regarded as having non-rotavirus diarrhoea. Enterotoxigenic Esch. coli. was isolated from seven patients of whom six yielded stable toxin producers (ST+), four labile toxin producers (LT+) and two dual toxigenic strains (ST+/LT+). All ST+ isolates appeared to be of low enterotoxigenicity as indicated by low gut weight/carcass weight ratios in the infant mouse assay. Rotavirus was the commonest aetiological agent (72 per cent), bacterial pathogens (alone) accounted for only five per cent and no enteric pathogens were found in 15 per cent of cases. Non-agglutinable rotavirus, presumably a different serotype, was seen in both gastroenteritis and control patients. Rotavirus ‘satellite’ particles previously undescribed were demonstrated in a number of stool samples. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133635/ doi: 10.1016/s0163-4453(79)90677-7 id: cord-301148-duttw9xn author: Golestanieraghi, Majid title: Early application of prone position for management of Covid-19 patients date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.jclinane.2020.109917 doi: 10.1016/j.jclinane.2020.109917 id: cord-260119-pgu2crhs author: Golledge, Jonathan title: The Potential Role of Sensors, Wearables and Telehealth in the Remote Management of Diabetes-Related Foot Disease date: 2020-08-13 words: 6769.0 sentences: 343.0 pages: flesch: 45.0 cache: ./cache/cord-260119-pgu2crhs.txt txt: ./txt/cord-260119-pgu2crhs.txt summary: Four randomised controlled trials have examined the efficacy of daily home foot temperature monitoring to signal the need for offloading in people at risk of diabetes-related foot ulcers [17] [18] [19] [20] . The previous trials testing home foot temperature monitoring [17] [18] [19] have excluded people with peripheral artery disease (PAD), which is an established risk factor for foot ulceration, thereby limiting the generalizability [20] [21] [22] . The cost-effectiveness and cost-utility of at-home infrared temperature monitoring in reducing the incidence of foot ulcer recurrence in patients with diabetes (DIATEMP): Study protocol for a randomized controlled trial Preventing diabetic foot ulcer recurrence in high-risk patients: Use of temperature monitoring as a self-assessment tool A pilot study testing the feasibility of skin temperature monitoring to reduce recurrent foot ulcers in patients with diabetes-a randomized controlled trial abstract: Diabetes-related foot disease (DFD), which includes foot ulcers, infection and gangrene, is a leading cause of the global disability burden. About half of people who develop DFD experience a recurrence within one year. Long-term medical management to reduce the risk of recurrence is therefore important to reduce the global DFD burden. This review describes research assessing the value of sensors, wearables and telehealth in preventing DFD. Sensors and wearables have been developed to monitor foot temperature, plantar pressures, glucose, blood pressure and lipids. The monitoring of these risk factors along with telehealth consultations has promise as a method for remotely managing people who are at risk of DFD. This approach can potentially avoid or reduce the need for face-to-face consultations. Home foot temperature monitoring, continuous glucose monitoring and telehealth consultations are the approaches for which the most highly developed and user-friendly technology has been developed. A number of clinical studies in people at risk of DFD have demonstrated benefits when using one of these remote monitoring methods. Further development and evidence are needed for some of the other approaches, such as home plantar pressure and footwear adherence monitoring. As yet, no composite remote management program incorporating remote monitoring and the management of all the key risk factors for DFD has been developed and implemented. Further research assessing the feasibility and value of combining these remote monitoring approaches as a holistic way of preventing DFD is needed. url: https://www.ncbi.nlm.nih.gov/pubmed/32823514/ doi: 10.3390/s20164527 id: cord-278319-44bvju3g author: Gonzales, Ralph title: Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background date: 2001-06-30 words: 4804.0 sentences: 258.0 pages: flesch: 39.0 cache: ./cache/cord-278319-44bvju3g.txt txt: ./txt/cord-278319-44bvju3g.txt summary: Four prospective studies (1984 to 1990) examined the accuracy of patient history and physical examination for diagnosing radiographic pneumonia in adults with acute respiratory illness in outpatient and emergency department settings, and a clinical decision tool to determine the need for radiography was developed. [42] [43] [44] [45] [46] [47] [48] [49] [50] By the mid-1990s, published reviews of randomized, placebo-controlled trials 51,52 had concluded that routine antibiotic treatment of acute bronchitis does not have a consistent impact on duration or severity of illness or on potential complications, such as development of pneumonia. In epidemiologic studies, respiratory viruses, particularly influenza, appear to cause the large majority of cases of uncomplicated acute bronchitis according to culture, antibody (48) productive cough of any times daily for 10 days group (n = 24) vs. Randomized, controlled trials have demonstrated a consistent benefit of therapy with albuterol versus placebo for uncomplicated acute bronchitis in reducing the duration and severity of cough (in one study, the "placebo" was erythromycin). abstract: Abstract The following principles of appropriate antibiotic use for adults with acute bronchitis apply to immunocompetent adults without complicating comorbid conditions, such as chronic lung or heart disease. 1. The evaluation of adults with an acute cough illness or a presumptive diagnosis of uncomplicated acute bronchitis should focus on ruling out serious illness, particularly pneumonia. In healthy, nonelderly adults, pneumonia is uncommon in the absence of vital sign abnormalities or asymmetrical lung sounds, and chest radiography is usually not indicated. In patients with cough lasting 3 weeks or longer, chest radiography may be warranted in the absence of other known causes. 2. Routine antibiotic treatment of uncomplicated acute bronchitis is not recommended, regardless of duration of cough. If pertussis infection is suspected (an unusual circumstance), a diagnostic test should be performed and antimicrobial therapy initiated. 3. Patient satisfaction with care for acute bronchitis depends most on physician–patient communication rather than on antibiotic treatment. [Gonzales R, Bartlett JG, Besser RE, Cooper RJ, Hickner JM, Hoffman JR, Sande MA. Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: background. Ann Emerg Med. June 2001;37:720-727.] url: https://api.elsevier.com/content/article/pii/S0196064401700911 doi: 10.1067/s0196-0644(01)70091-1 id: cord-259699-48jg7ci7 author: González-Calatayud, Dra Mariel title: Observational study of the suspected or confirmed cases of sars COV-2 infection needing emergency surgical intervention during the first months of the pandemic in a third level hospital: Case series date: 2020-10-24 words: 2797.0 sentences: 131.0 pages: flesch: 46.0 cache: ./cache/cord-259699-48jg7ci7.txt txt: ./txt/cord-259699-48jg7ci7.txt summary: METHOD: We conducted an observational study of patients undergoing surgical intervention in the operating room assigned as COVID, where we considered age, sex, treating department, type of intervention, and initial biomarkers (first five days of hospitalization), days of hospital stay, days in the Intensive Care Unit and reason for discharge. We conducted an observational study of patients undergoing surgical intervention in the operating room assigned as COVID, where we considered age, sex, treating department, type of intervention, and initial laboratory tests (first five days of hospitalization): ferritin, D-dimer, total leucocyte count, total lymphocyte count, lymphocytes (%), platelets, lactate dehydrogenase, fibrinogen, and procalcitonin; we also considered days of hospital stay (DOHS), days in the Intensive Care Unit (ICU), and reason for discharge. Indeed, it has been decided to reduce elective surgical treatment, we have also observed that patients undergoing emergency surgery with suspicion or confirmation of SARS-Cov-2 infection have significant mortality depending on the performed surgical procedure, without relevant findings regarding biomarkers. abstract: Approximately 28, 404, 603 surgical events have been suspended in the 12 peak weeks of the COVID-19 pandemic. The aim of this study was to report all the surgically intervened patients with suspected or confirmed SARS CoV-2 infection from April 1 to July 31, 2020, and to estimate their prognosis in the Surgical Therapy Department of a third level hospital in Mexico. METHOD: We conducted an observational study of patients undergoing surgical intervention in the operating room assigned as COVID, where we considered age, sex, treating department, type of intervention, and initial biomarkers (first five days of hospitalization), days of hospital stay, days in the Intensive Care Unit and reason for discharge. RESULTS: 42 patients have been surgically intervened, with a total of 49 surgeries. For Otolaringology and General Surgery, there were more deceased cases than alive cases; while for Thoracic Surgery, and Obstetrics and Gynecology, there were more alive cases than deceased ones (36% and 0% deceased, respectively), with statistically significant differences (p = 0.014). With regard to mortality for each group of surgical procedure, patients who underwent C-section or pleurostomy had a mortality rate of 0%; the mortality rate for patients who underwent tracheostomy was 52%; patients who underwent laparotomy had a mortality rate of 54%; for those who underwent debridement, the mortality rate was 100%; which show significant differences, with a p value of 0.03. DISCUSSION: we identified an overall mortality rate of 42.8%, with a significant difference between treating departments and type of surgical procedure. This can be explained because many of the General Surgery patients, in addition to their infectious process by COVID-19, had another complication, like sepsis, In the same way, we can say that pregnant patients are healthy and have a physiological condition. Finally, patients undergoing an open tracheostomy had solely pulmonary complications. CONCLUSION: There is no doubt that we face an unknown condition for which we have been learning tests along the way. This sample of cases undergoing surgery at the beginning of the COVID-19 pandemic can provide clues on relevant results that we must consider for future cases. url: https://www.sciencedirect.com/science/article/pii/S2049080120303939?v=s5 doi: 10.1016/j.amsu.2020.10.038 id: cord-351604-x4rsdwqz author: González-Gay, Miguel A. title: BioLogic THERAPY IN COVID-19 date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32654852/ doi: 10.1016/j.arbres.2020.06.007 id: cord-304479-uxp1kg86 author: Goodarzi, Pedram title: Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments date: 2020-08-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The SARS-CoV-2 virus is an etiological agent of pandemic COVID-19, which spreads rapidly worldwide. No proven effective therapies currently exist for this virus, and efforts to develop antiviral strategies for the treatment of COVID-19 are underway. The rapidly increasing understanding of SARS-CoV-2 virology provides a notable number of possible immunological procedures and drug targets. However, gaps remain in our understanding of the pathogenesis of COVID-19. In this review, we describe the latest information in the context of immunological approaches and emerging current antiviral strategies for COVID-19 treatment. url: https://api.elsevier.com/content/article/pii/S1567576920323092 doi: 10.1016/j.intimp.2020.106885 id: cord-263599-cqol8zf2 author: Goodman, Larry title: Infectious diarrhea date: 1999-07-31 words: 11532.0 sentences: 640.0 pages: flesch: 50.0 cache: ./cache/cord-263599-cqol8zf2.txt txt: ./txt/cord-263599-cqol8zf2.txt summary: A large number of organisms have been associated with diarrhea in humans, and most laboratories routinely screen for Salmonella, Shigella, and Campylobacter. Patients with these conditions requhe prompt treatment, A large number of organisms have been associated with diarrhea in humans, and most laboratories routinely screen for Salmonella, ShigelEa, and Campylobacter. Incubation periods shorter than 12 hours suggest an enterotoxin-producing organism; fever and white blood cells in the stool are generally associated with an invasive pathogen. A recent report about a food-borne outbreak demonstrated that ETEC was also a cause of diarrhea in patients who had not been traveling.30 ETEC organisms were isolated from 5 people who had attended a labor union banquet in Milwaukee with attendees from throughout the United States. 70 However, similar studies are not available for infections caused by an invasive organism such as Salmonella, Shigella, or Campylobacter or for C d@cileassociated diarrhea. abstract: Abstract Infectious diarrhea is an extremely common illness that affects millions of Americans annually. For most patients, the illness is a self-limited one. Its major risk is dehydration. However, for some patients, diarrhea can lead to severe dehydration or be associated with bacteremia and metastatic infection. Patients with these conditions require prompt treatment. A large number of organisms have been associated with diarrhea in humans, and most laboratories routinely screen for Salmonella, Shigella, and Campylobacter. Other bacteria, parasites, and viruses account for a significant percentage of diarrhea cases and frequently go undetected. This article summarizes many of these pathogens and describes the settings in which they can be acquired. Food distribution networks have made the delivery of previously rare foods to remote areas a commonplace occurrence; this has also led to new challenges in the diagnosis and prevention of food-borne illnesses. Outbreaks of diarrhea now frequently extend across many states. The identification of a rare strain of a bacterial pathogen or changes in the isolation rate of common pathogens may be early clues to the cause of such an ongoing outbreak. Most enteric pathogens cause disease by either stimulating the secretion of fluids at the level of the small bowel or by irritating and invading the colon. Organisms that cause disease by the latter mechanism have the potential to invade the blood stream and spread to other parts of the body, including the bones and the central nervous system. Several organisms have been associated with specific postinfectious syndromes that are responsible for additional morbidity and mortality. The antibiotic resistance of bacterial pathogens has been increasing, and this has a limiting effect on the empiric treatment choices available for suspected bacterial diarrhea. Careful attention to local sensitivity patterns and appropriate testing of the patient's isolate are among the important factors that lead to successful treatment decisions. url: https://www.ncbi.nlm.nih.gov/pubmed/10480543/ doi: 10.1016/s0011-5029(99)90000-7 id: cord-288255-p8uzrsbd author: Goossens, Gijs H. title: Obesity and COVID-19: A Perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity date: 2020-08-13 words: 7043.0 sentences: 333.0 pages: flesch: 36.0 cache: ./cache/cord-288255-p8uzrsbd.txt txt: ./txt/cord-288255-p8uzrsbd.txt summary: authors: Goossens, Gijs H.; Dicker, Dror; Farpour-Lambert, Nathalie J.; Frühbeck, Gema; Mullerova, Dana; Woodward, Euan; Holm, Jens-Christian Evidence from studies in humans indicates that people with obesity are characterized by systemic low-grade inflammation, higher susceptibility to infections, dampened immune response to infectious agents, as well as higher morbidity and mortality associated with infections, and demonstrate an impaired immune response to vaccinations and antimicrobial treatment [25] [26] [27] [28] . Together, these findings imply that evaluation of cytokine profiles and immune cell subsets in patients with SARS-CoV-2 infection, and a deeper understanding of the underlying processes, will significantly contribute to better treatment strategies and clinical management of COVID-19 [37] . At the same time, the rapidly emerging clinical data require ongoing scrutiny to understand not only the risks and benefits of single drugs to tackle COVID-19, but also the interaction with pharmacological agents commonly used in people with obesity and related NCDs, including type 2 diabetes and cardiovascular diseases, who are especially at risk of or hospitalized with SARS-CoV-2 infection. abstract: Accumulating evidence suggests that obesity is a major risk factor for the initiation, progression, and outcomes of coronavirus disease 2019 (COVID-19). The European Association for the Study of Obesity (EASO), as a scientific and medical society dedicated to the promotion of health and well-being, is greatly concerned about the concomitant obesity and COVID-19 pandemics and their impact on health and society at large. In this perspective, we will address the inherent immunological perturbations and alterations in the renin-angiotensin-aldosterone system in patients with obesity and COVID-19, and discuss how these impairments may underlie the increased susceptibility and more detrimental outcomes of COVID-19 in people with obesity. Clearly, this has important implications for preventive measures, vaccination, and future therapeutic strategies to combat COVID-19. Furthermore, we will highlight important knowledge gaps and provide suggestions for future research and recommendations for policy actions. Since many new reports on COVID-19 rapidly appear, the present perspective should be seen as a focus for discussion to drive forward further understanding, research initiatives, and clinical management of COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32791497/ doi: 10.1159/000510719 id: cord-005606-c8c2rfzi author: Gordon, Sharon M. title: Clinical identification of cognitive impairment in ICU survivors: insights for intensivists date: 2004-10-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: A growing body of research has demonstrated the presence of ongoing cognitive impairment in large numbers of ICU survivors. OBJECTIVE: This review offers a practical framework for practicing intensivists and those following patients after their ICU stay for the identification of cognitive impairment in ICU survivors. CONCLUSIONS: Early detection of cognitive impairment in critically ill patients is an important and achievable goal, but overt cognitive impairment remains unrecognized in most cases. However, it can be identified by objective (test scores) or subjective evidence (clinical judgment, patient observation, family interaction). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094980/ doi: 10.1007/s00134-004-2418-y id: cord-291016-c83fs5ih author: Gori, Tommaso title: Perspective: cardiovascular disease and the Covid-19 pandemic date: 2020-04-10 words: 1623.0 sentences: 71.0 pages: flesch: 42.0 cache: ./cache/cord-291016-c83fs5ih.txt txt: ./txt/cord-291016-c83fs5ih.txt summary: Furthermore, the new, emergency-driven changes to hospital logistics conflict with important principles of treatment of patients with acute coronary syndromes: patients with an undefined contact history or ambiguous symptoms are often approached as potential Sars-Cov-2 positive at the time of their medical contact. It is now of paramount importance that communication media inform the population that most large centers have restructured their admission protocols to provide a rapid and Covid-secure care of patients with acute coronary syndromes while still addressing the diagnosis of Sars-CoV-2 infection. International experts and the European Society of Cardiology "strongly recommend that physicians and patients should continue treatment with their usual anti-hypertensive therapy", given the lack of clinical or scientific evidence to suggest that treatment with angiotensin-converting enzyme inhibitors or angiotensinreceptor blockers might favor the spread or the severity of Sars-CoV-2 infection [9] . abstract: We summarize the cardiovascular risks associated with Covid-19 pandemic, discussing the risks for both infected and non-infected patients. url: https://doi.org/10.1007/s00395-020-0792-4 doi: 10.1007/s00395-020-0792-4 id: cord-267947-dnv2xl0h author: Gornet, Jean-Marc title: What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19? date: 2020-04-24 words: 3745.0 sentences: 167.0 pages: flesch: 40.0 cache: ./cache/cord-267947-dnv2xl0h.txt txt: ./txt/cord-267947-dnv2xl0h.txt summary: Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. At the outset of the epidemic, there was a reported case of a 22-year-old female patient presenting with isolated febrile diarrhea along with normal blood test and negative fecal culture; on the other hand, chest scan revealed bilateral pneumopathy suggesting COVID-19 [7] . In a recent retrospective study involving 1141 patients presenting with documented infection, the frequency of initially isolated digestive disorders came to 16%, whereas in 96% of cases, injured lungs appeared on CT-scan [8] . This has also been reported in COVID-19, with a well-documented case of positive RT-PCR results in stools (during 7 days after hospital admission there were also 4 other negative RT-PCR test results, 2 on throat swabs, and the other 2 on sputum) in a patient presenting with non-severe bilateral pneumopathy [14] . abstract: Abstract The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. However, digestive symptoms have also been reported; at first considered as infrequent, they in fact seem to affect (to some extent) more than half of patients. The symptoms are mainly manifested by anorexia, diarrhea, nausea and/or vomiting and abdominal pain. Even though prognosis is associated with lung injury, digestive symptoms seem significantly more frequent in patients presenting with severe COVID-19 infection. Digestive forms, which may be isolated or which can precede pulmonary symptoms, have indeed been reported, with diarrhea as a leading clinical sign. The main biological abnormalities that can suggest COVID-19 infection at an early stage are lymphopenia, elevated CRP and heightened ASAT transaminases. Thoraco-abdominal scan seems useful as a means of on the one hand ruling out digestive pathology not connected with coronavirus and on the other hand searching for pulmonary images compatible with COVID-19 infection. No data exist on the interest of digestive endoscopy in cases of persistent digestive symptoms. Moreover, the endoscopic surgeons may themselves be at significant risk of contamination. Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. In some doubtful cases, virologic assessment of stool samples can yield definitive diagnosis. In the event of prolonged viral shedding in stools, a patient’s persistent contagiousness is conceivable but not conclusively established. Upcoming serology should enable identification of the patients having been infected by the COVID-19 epidemic, particularly among previously undetected pauci-symptomatic members of a health care staff. Resumption of medico-surgical activity should be the object of a dedicated strategy preceding deconfinement. url: https://www.ncbi.nlm.nih.gov/pubmed/32360205/ doi: 10.1016/j.jviscsurg.2020.04.017 id: cord-277260-7se220oz author: Gosain, Rohit title: COVID-19 and Cancer: a Comprehensive Review date: 2020-05-08 words: 5926.0 sentences: 306.0 pages: flesch: 39.0 cache: ./cache/cord-277260-7se220oz.txt txt: ./txt/cord-277260-7se220oz.txt summary: Since the emergence of the first case in Wuhan, China, in December 2019, tremendous research efforts have been underway to understand the mechanisms of infectivity and transmissibility of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a fatal virus responsible for abysmal survival outcomes. Data from China thus far have shown that cancer patients infected with COVID-19 are at 3.5 times the risk of requiring mechanical ventilation or ICU admission, compared to the general population [9•] . The CALAVI trial will be initiated as a randomized global clinical trial to assess the potential of acalabrutinib in the treatment of the cytokine storm associated with severely ill COVID-19 patients [86] . An exploratory meta-analysis of 32 studies showed evidence of reduced mortality after receiving various doses of convalescent plasma in patients with severe acute respiratory infections of viral etiology [92] . Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China abstract: PURPOSE OF REVIEW: The outbreak of the novel coronavirus disease 2019 (COVID-19) has emerged to be the biggest global health threat worldwide, which has now infected over 1.7 million people and claimed more than 100,000 lives around the world. Under these unprecedented circumstances, there are no well-established guidelines for cancer patients. RECENT FINDINGS: The risk for serious disease and death in COVID-19 cases increases with advancing age and presence of comorbid health conditions. Since the emergence of the first case in Wuhan, China, in December 2019, tremendous research efforts have been underway to understand the mechanisms of infectivity and transmissibility of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a fatal virus responsible for abysmal survival outcomes. To minimize the mortality rate, it becomes prudent to identify symptoms promptly and employ treatments appropriately. Even though no cure has been established, multiple clinical trials are underway to determine the most optimal strategy. Managing cancer patients under these circumstances is rather challenging, given their vulnerable status and the aggressive nature of their underlying disease. SUMMARY: In this comprehensive review, we discuss the impact of COVID-19 on health and the immune system of those affected, reviewing the latest treatment approaches and ongoing clinical trials. Additionally, we discuss challenges faced while treating cancer patients and propose potential approaches to manage this vulnerable population during this pandemic. url: https://doi.org/10.1007/s11912-020-00934-7 doi: 10.1007/s11912-020-00934-7 id: cord-002977-o0dvwzxk author: Gosangi, Babina title: Review of targeted therapy in chronic lymphocytic leukemia: what a radiologist needs to know about CT interpretation date: 2018-04-18 words: 5462.0 sentences: 239.0 pages: flesch: 36.0 cache: ./cache/cord-002977-o0dvwzxk.txt txt: ./txt/cord-002977-o0dvwzxk.txt summary: Using CLL as a case study, we present a timeline and overview of the current treatment landscape for the radiologist, including an overview of clinical and radiological features of CLL, discussion of the targeted agents themselves, and the role of imaging in response and toxicity assessment. In this review, using CLL as a case study, we summarize the clinical and radiological features of this disease and discuss the various targeted therapies used to treat CLL and other indolent lymphomas, with emphasis on the role of imaging in toxicity assessment. Despite these potential toxicities, each of Fig. 9 a 78-year-old female patient with CLL on treatment with Idelalisib with pneumonitis, axial CT of the chest obtained in arterial phase demonstrates bilateral patchy areas of ground glass and consolidative opacities. abstract: The last 5 years have been marked by profound innovation in the targeted treatment of chronic lymphocytic leukemia (CLL) and indolent lymphomas. Using CLL as a case study, we present a timeline and overview of the current treatment landscape for the radiologist, including an overview of clinical and radiological features of CLL, discussion of the targeted agents themselves, and the role of imaging in response and toxicity assessment. The goal is to familiarize the radiologist with multiple Food and Drug Administration (FDA)-approved targeted agents used in this setting and associated adverse events which are commonly observed in this patient population. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907417/ doi: 10.1186/s40644-018-0146-8 id: cord-322746-28igib4l author: Gosche, John R. title: Acute, subacute, and chronic cervical lymphadenitis in children date: 2007-06-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Lymphadenopathy refers to any disease process involving lymph nodes that are abnormal in size and consistency. Lymphadenitis specifically refers to lymphadenopathies that are caused by inflammatory processes. Cervical lymphadenopathy is a common problem in the pediatric age group and is largely inflammatory and infectious in etiology. Although most patients are treated successfully by their primary care physician, surgical consultation is frequently required for patients who fail to respond to initial therapy or for those in whom there is an index of suspicion for a neoplastic process. This article addresses current approaches to the diagnosis and management of cervical lymphadenitis in children. url: https://www.ncbi.nlm.nih.gov/pubmed/16616313/ doi: 10.1053/j.sempedsurg.2006.02.007 id: cord-287991-10jz1dz2 author: Goshen-Lago, Tal title: The Potential Role of Immune Alteration in the Cancer–COVID19 Equation—A Prospective Longitudinal Study date: 2020-08-26 words: 4497.0 sentences: 235.0 pages: flesch: 47.0 cache: ./cache/cord-287991-10jz1dz2.txt txt: ./txt/cord-287991-10jz1dz2.txt summary: Conclusion: Our results indicate a similar rate of asymptomatic COVID19 infection in cancer patients and healthcare workers in a longitudinal study throughout the pandemic time. During the study interval, there was no documented symptomatic case of COVID19 among the recruited participants, nor in the general patient population of the cancer center or in the healthcare workers cohort. Furthermore, when analyzing the myeloid lineage, we found a substantial increase in myeloid cells in cancer patients compared to healthcare workers (both SARS-CoV-2 IgG-), in line with previous studies [11, 12] . Our results may indicate that due to differential immune cell profile of cancer patients who are treated with immunomodulatory agents, the host response to the SARS-COV2 may lessen symptom severity. Our results may indicate that due to differential immune cell profile of cancer patients who are treated with immunomodulatory agents, the host response to the SARS-COV2 may lessen symptom severity. abstract: SIMPLE SUMMARY: Despite lack of concrete evidence, cancer patients were considered at the onset of the COVID19 pandemic as high-risk population for COVID19 infection. However, current evidence is inconclusive and the potential role of cancer or anti-neoplastic treatments in COVID19 course remains to be elucidated. Our results may indicate that due to differential immune cell profile of cancer patients who are treated with immunomodulatory agents the host response to the SARS-COV2 may lessen symptom severity. Delineating COVID-19 infection trends in asymptomatic healthcare workers as well as a cohort of cancer patients who are on active anti-cancer treatment will lend credence to tailor future healthcare policy in the next phases of the pandemic. ABSTRACT: Background: The risk of cancer patients to develop COVID19 infection is unclear. We aimed to prospectively study cancer patients and oncology healthcare workers for COVID19 serology. In IgG+ cases, immune profile was determined to portray the pattern of immune response to SARS-CoV2. Methods: Cancer patients on active treatment and healthcare workers were enrolled. During the study period (3/2020–6/2020), demographic data and blood were collected at three time points. Expression of IgG, IgM, and IgA were assessed. In SARS-CoV-2 IgG+ cases and matched negative cases, we performed mass cytometry time of flight (CyTOF) analysis on the basis of the expression of surface markers. Results: The study included 164 cancer patients on active intravenous treatment and 107 healthcare workers at the cancer center. No symptomatic cases were reported during the study period. Serology analysis revealed four IgG+ patients (2.4%) and two IgG+ healthcare workers (1.9%)—all were asymptomatic. CyTOF analysis demonstrated substantial reduction in myeloid cells in healthcare workers who were SARS-CoV-2 IgG+ compared to those who were SARS-CoV-2 IgG-, whereas in cancer patients, the reduction was relatively milder (≈50% reduction in SARS-CoV-2 IgG+ cancer patients compared with ≈90% reduction in SARS-CoV-2 IgG+ workers). Conclusion: Our results indicate a similar rate of asymptomatic COVID19 infection in cancer patients and healthcare workers in a longitudinal study throughout the pandemic time. Due to differential immune cell profiles of cancer patients who are treated with immunomodulatory agents, the host response to the SARS-COV2 may play a role in COVID19 course and representation. The immunological perspective of cancer treatments on the risk for COVID19 infection should be further explored. url: https://doi.org/10.3390/cancers12092421 doi: 10.3390/cancers12092421 id: cord-257408-ejhhk1iu author: Goss, Matthew B. title: The Pediatric Solid Organ Transplant Experience with COVID‐19: An Initial Multi‐Center, Multi‐Organ Case Series date: 2020-09-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The clinical course of COVID‐19 in pediatric solid organ transplant recipients remains ambiguous. Though preliminary experiences with adult transplant recipients have been published, literature centered on the pediatric population is limited. We herein report a multi‐center, multi‐organ cohort analysis of COVID‐19 positive transplant recipients ≤ 18 years at time of transplant. METHODS: Data were collected via institutions’ respective electronic medical record systems. Local review boards approved this cross‐institutional study. RESULTS: Among 5 transplant centers, 26 patients (62% male) were reviewed with a median age of 8 years. 6 were heart recipients, 8 kidney, 10 liver, and 2 lung. Presenting symptoms included cough (n=12 (46%)), fever (n=9 (35%)), dry/sore throat (n=3 (12%)), rhinorrhea (n=3 (12%)), anosmia (n=2 (8%)), chest pain (n=2 (8%)), diarrhea (n=2 (8%)), dyspnea (n=1 (4%)), and headache (n=1 (4%)). Six patients (23%) were asymptomatic. No patient required supplemental oxygen, intubation, or ECMO. Eight patients (31%) were hospitalized at time of diagnosis, 3 of whom were already admitted for unrelated problems. Post‐transplant immunosuppression was reduced for only 2 patients (8%). All symptomatic patients recovered within 7 days. CONCLUSIONS: Our multi‐institutional experience suggests the prognoses of pediatric transplant recipients infected with COVID‐19 may mirror those of immunocompetent children, with infrequent hospitalization and minimal treatment, if any, required. url: https://doi.org/10.1111/petr.13868 doi: 10.1111/petr.13868 id: cord-262068-9ixq8hwb author: Gottardi, Andrea De title: Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection date: 2020-06-10 words: 1773.0 sentences: 119.0 pages: flesch: 49.0 cache: ./cache/cord-262068-9ixq8hwb.txt txt: ./txt/cord-262068-9ixq8hwb.txt summary: The data that support the findings of this study are available from the corresponding author, upon Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection SUMMARY We present here the case of a 62-year-old man, who was referred to the emergency department with fever and cough for 3 days. Therefore, due to the potential clinical efficacy for COVID-19 patients [11] and based on SARS clinical cases in 2003 [12] , and before the publication of the LOTUS China trial [13] , we started a treatment with lopinavir 200 mg and ritonavir 50 mg 2-0-2, and hydroxychloroquine 200 mg twice daily. Clinical data available so far indicate that up to 53% of the patients with COVID-19 present increased levels of transaminases during the infection and that liver injury is apparently associated with the severity of respiratory symptoms [14, 15] . abstract: SUMMARY We present here the case of a 62-year-old man, who was referred to the emergency department with fever and cough for 3 days. He underwent liver transplantation 4 years earlier due to HCV and NASH-related cirrhosis with hepatocellular carcinoma. At admission he was in reduced general conditions. Nasopharyngeal smear specimen resulted positive for SARS-CoV-2 infection. Pulmonary low-dose CT-scan revealed bilateral subpleural ground-glass infiltrates. O2 saturation was 93%. A treatment with lopinavir/ritonavir and hydroxychloroquine twice daily was started. The patient received also cefepime and remained in isolation. Seven days later imaging showed a progression of the pulmonary infiltrates. Cefepime was replaced by meropenem. During the following 3 days the fever resolved, and the general conditions of the patient significantly improved. Consequently, treatment with lopinavir/ritonavir and hydroxychloroquine was stopped. The evolution of SARS-CoV-2 interstitial pneumonia in this immunosuppressed patient was moderate to severe and liver injury was not clinically significant. Despite its limitations, this case report confirm that the liver may be only mildly affected during SARS-CoV-2 infection, also in liver transplanted patients. Further studies are needed to assess whether the outcome of SARS-CoV-2 infection is worse in immunosuppressed patients than in the general population. url: https://doi.org/10.1016/j.clinre.2020.05.014 doi: 10.1016/j.clinre.2020.05.014 id: cord-288790-5uzgenty author: Govil, Gaurav title: Rehabilitation of Arthroplasty Patient During Covid-19 date: 2020-05-24 words: 321.0 sentences: 27.0 pages: flesch: 50.0 cache: ./cache/cord-288790-5uzgenty.txt txt: ./txt/cord-288790-5uzgenty.txt summary: key: cord-288790-5uzgenty title: Rehabilitation of Arthroplasty Patient During Covid-19 cord_uid: 5uzgenty The established protocols were sidelined and patients asked to care on their own with dictum being "stay home and stay safe". The majority may respond well to the rehabilitation protocols adopted in pre-Covid era [4] . The induction of patient into an orthopaedic or arthroplasty programme should be a systematic team approach with the inclusion of established patient-specific home-based rehabilitation protocol. Plans that need consideration [3] are: Physical therapy will be even more crucial in the medium to long-term response to assist the orthopaedic and arthroplasty patient to regain optimal function and to help them return to their previous level of activities [3] . Management of orthopaedic patients during COVID-19 pandemic in India: A guide Orthopaedics in times of COVID 19 Total knee arthroplasty rehabilitation protocol: What makes the difference? abstract: nan url: https://doi.org/10.1007/s43465-020-00144-0 doi: 10.1007/s43465-020-00144-0 id: cord-264368-p2fwuh0i author: Gozgec, Elif title: Left Ventricular Thrombus in a Patient Infecting by Covid-19 date: 2020-07-28 words: 246.0 sentences: 26.0 pages: flesch: 55.0 cache: ./cache/cord-264368-p2fwuh0i.txt txt: ./txt/cord-264368-p2fwuh0i.txt summary: key: cord-264368-p2fwuh0i title: Left Ventricular Thrombus in a Patient Infecting by Covid-19 cord_uid: p2fwuh0i A 74-year-old woman presented with general condition disorder, nausea and vomiting. The patient had general condition disorder but had no known systemic disease, history of trauma, or medication. Thorax computed tomography (CT) showed bilateral pleural effusion, consolidated areas with air bronchogram in the right hilar region, ground-glass densities in some peripheral locations ( Figure 1A) , abnormal enlargement of the left ventricular apex, and a hypodense appearance that could be compatible with thrombus ( Figure 1B-C, asterisks) . With the present findings, the patient was diagnosed with multiple organ failure due to possible COVID-19. The COVID-19 disease, which has been declared a pandemic by the world health organization, has a variable spectrum of symptoms from asymptomatic carriers to multiple organ failure. These patients have been shown to be susceptible to thrombus. Ventricular thrombus as in our case is a very rare condition. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32735791/ doi: 10.1016/j.athoracsur.2020.07.008 id: cord-321801-w66v5kzh author: Grabala, Jolanta title: Possibilities of using ultrasound for diagnosis of invasive pulmonary mucormycosis – A case study date: 2017-08-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Introduction Mucormycosis is a rare but highly lethal fungal infection, usually affecting immunocompromised patients. Aim To present and analyze the diagnostic capabilities of transthoracic ultrasonography in invasive pulmonary mucormycosis. Case study We present a case involving a 41-year-old female patient with pneumonia complicated by multisystem organ failure, who was diagnosed with invasive pulmonary mucormycosis. Results and discussion Transthoracic ultrasonography (TUS) revealed a consolidation area of heterogeneous echostructure with an abnormal air bronchogram, possibly suggestive of an invasive pulmonary fungal disorder. The presence of lesions observed with TUS was confirmed by computed tomography (CT). The final diagnosis of mucormycosis was possible after Mucor species fungi were detected in bronchoalveolar lavage culture. Conclusions (1) TUS is a widely available and inexpensive diagnostic method that is characterized by the absence of adverse effects, and its applicability in the diagnosis of pulmonary disorders other than invasive fungal infections is well documented. (2) Ultrasonographic analysis of lesions facilitates differentiation between bacterial and fungal pneumonia, and the high sensitivity and specificity of the procedure compared to CT scans as a reference method supports the reliability of ultrasound scans in the diagnosis of invasive pulmonary aspergillosis (IPA). (3) The use of TUS in the diagnosis of invasive pulmonary mucormycosis appears warranted, particularly in cases when it is impossible to obtain a proven diagnosis. (4) Ultrasonographic diagnosis of invasive lung disorders, including mucormycosis, requires further studies. url: https://api.elsevier.com/content/article/pii/S1230801316300546 doi: 10.1016/j.poamed.2016.11.004 id: cord-333340-ekok0mp5 author: Graf, Erin H. title: Appropriate Use and Future Directions of Molecular Diagnostic Testing date: 2020-02-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: Major technologic advances in two main areas of molecular infectious disease diagnostics have resulted in accelerated adoption or ordering, outpacing implementation, and clinical utility studies. Physicians must understand the limitations to and appropriate utilization of these technologies in order to provide cost-effective and well-informed care for their patients. RECENT FINDINGS: Rapid molecular testing and, to a lesser degree, clinical metagenomics are now being routinely used in clinical practice. While these tests allow for a breadth of interrogation not possible with conventional microbiology, they pose new challenges for diagnostic and antimicrobial stewardship programs. This review will summarize the most recent literature on these two categories of technologic advances and discuss the few studies that have looked at utilization and stewardship approaches. This review also highlights the future directions for both of these technologies. SUMMARY: The appropriate utilization of rapid molecular testing and clinical metagenomics has not been well established. More studies are needed to assess their prospective impacts on patient management and antimicrobial stewardship efforts as the future state of infectious disease diagnostics will see continued expansion of these technologic advances. url: https://doi.org/10.1007/s11908-020-0714-5 doi: 10.1007/s11908-020-0714-5 id: cord-335540-lahu5dno author: Granata, Tiziana title: Did the COVID‐19 pandemic silence the needs of people with epilepsy? date: 2020-09-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Aims. The COVID‐19 pandemic shook European healthcare systems, with unavoidable gaps in the management of patients with chronic diseases. We describe the impact of the pandemic on epilepsy care in three tertiary epilepsy centres from Spain and Italy, the most affected European countries. Methods. The three epilepsy centres, members of the European EpiCARE network, manage more than 5,700 people with epilepsy. In Bologna and Barcelona, the hospitals housing the epilepsy centres were fully converted into COVID‐19 units. We describe the reorganization of the clinics and report on the frequency of SARS‐CoV‐2 in people with epilepsy as well as the frequency of seizures in patients admitted to the COVID units. Finally, we elaborate on critical issues regarding the second phase of the pandemic. Results. The activities related to epilepsy care were reduced to less than 10% and were deprioritized. Discharges were expedited and elective epilepsy surgeries, including vagal nerve stimulator implantations, cancelled. Hospitalizations and EEG examinations were limited to emergencies. The outpatient visits for new patients were postponed, and follow‐up visits mostly managed by telehealth. Antiseizure medication weaning plans and changes in vagal nerve stimulator settings were halted. Among the 5,700 people with epilepsy managed in our centres, only 14 tested positive for SARS‐CoV‐2, without obvious impact on their epilepsy. None of the 2,122 patients admitted to COVID units experienced seizures among the early symptoms. Conclusion. Epilepsy care was negatively impacted by the pandemic, irrespective of COVID‐19 epidemiology or conversion of the hospital into a COVID‐19 centre. The pandemic did not silence the needs of people with epilepsy, and this must be considered in the planning of the second phase. url: https://www.ncbi.nlm.nih.gov/pubmed/32759092/ doi: 10.1684/epd.2020.1175 id: cord-324679-rds8o5z4 author: Grant, Vincent J. title: The Past, Present, and Future of Simulation-based Education for Pediatric Emergency Medicine date: 2016-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The pediatric emergency medicine (PEM) environment is well suited for simulation-based activities, be they educational interventions for PEM learners, evaluations of the interface between health providers and the environment that they work in, or research investigations using simulation as a tool to answer specific clinical questions. As such, PEM has been among the leaders in the integration of this modality for clinical training. Traditionally, simulation has been used extensively for the dissemination of clinical training in the areas of clinical knowledge and its application, and the clinical, technical, and teamwork skills involved in PEM care. Increasingly, simulation is being used in novel applications, including breaking bad news, disclosure of error, family-centered care, quality and patient safety education, and system-level integration. The future will look to further identify, measure, and inform the integration of simulation with new and innovative adjuncts in the clinical environment, as well as to determine the optimal timing and use of simulation-based education to enhance the quality of care delivered to patients by the interprofessional and multidisciplinary team. url: https://api.elsevier.com/content/article/pii/S1522840116300246 doi: 10.1016/j.cpem.2016.05.005 id: cord-315311-azamwuzl author: Grattagliano, Ignazio title: The changing face of family medicine in the covid and post‐covid era date: 2020-06-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In the last decade, family doctors (FD), mainly devoted to the management of elderly and multi‐morbid people, have become increasingly involved in managing patients under innovative therapy and by dealing with electronic health record systems providing faster connection with patients and other health workers. url: https://www.ncbi.nlm.nih.gov/pubmed/32506437/ doi: 10.1111/eci.13303 id: cord-005861-3k8h3euj author: Gravenstein, J. S. title: Safety in anesthesia date: 2014-03-17 words: 3660.0 sentences: 213.0 pages: flesch: 50.0 cache: ./cache/cord-005861-3k8h3euj.txt txt: ./txt/cord-005861-3k8h3euj.txt summary: Efforts to enhance safety in anesthesia must include adherence to explicit and implicit safety standards, must make use of equipment that offers modern safety features, must seek to detect and correct developing safety threats as early as possible and must have a structured system to analyze problems and to institute remedies to prevent their recurrence. The health care system in which these fatal and non-fatal errors occur covers a spectrum that stretches from the manufacturers of equipment and drugs to the cleaning crew in the operating room and it involves many different clinical and supportive departments and their personnel.Anesthesia is an important component of this health care system comprising many interdependent parts that can affect the quality of anesthesia care. The Institute of Medicine [5] includes in its definitions the terms "accidental injury" and, interestingly, makes reference to a process:"Ensuring patient safety involves the establishment of operational systems and processes that minimize the likelihood of errors and maximize the likelihood of intercepting them when they occur." abstract: The specialty of anesthesiology has made extraordinary advances in anesthesia safety. Yet, anesthetic mortality and morbidity continue to be far from tolerable. Efforts to enhance safety in anesthesia must include adherence to explicit and implicit safety standards, must make use of equipment that offers modern safety features, must seek to detect and correct developing safety threats as early as possible and must have a structured system to analyze problems and to institute remedies to prevent their recurrence. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095858/ doi: 10.1007/s00101-002-0319-4 id: cord-334235-ymsiihwd author: Gray, Belinda title: Patients with Genetic Heart Disease and COVID-19: A Cardiac Society of Australia and New Zealand (CSANZ) Consensus Statement date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract In the context of the current global COVID-19 pandemic, this Consensus Statement provides current recommendations for patients with, or at risk of developing, genetic heart disease, and for their health care management and service provision in Australia and New Zealand. Apart from general recommendations, there are specific recommendations for the following conditions: cardiomyopathy, Brugada syndrome (including in children), long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Other recommendations are relevant to patient self-care and primary health care. url: https://www.sciencedirect.com/science/article/pii/S1443950620301347?v=s5 doi: 10.1016/j.hlc.2020.04.006 id: cord-326834-eeldyj2u author: Graziani, Desirée title: Characteristics and Prognosis of COVID-19 in Patients with COPD date: 2020-10-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patients with Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence of coronary ischemia and other factors that put them at risk for COVID-19-related complications. We aimed to explore the impact of COVID-19 in a large population-based sample of patients with COPD in Castilla-La Mancha, Spain. We analyzed clinical data in electronic health records from 1 January to 10 May 2020 by using Natural Language Processing through the SAVANA Manager(®) clinical platform. Out of 31,633 COPD patients, 793 had a diagnosis of COVID-19. The proportion of patients with COVID-19 in the COPD population (2.51%; 95% CI 2.33–2.68) was significantly higher than in the general population aged >40 years (1.16%; 95% CI 1.14–1.18); p < 0.001. Compared with COPD-free individuals, COPD patients with COVID-19 showed significantly poorer disease prognosis, as evaluated by hospitalizations (31.1% vs. 39.8%: OR 1.57; 95% CI 1.14–1.18) and mortality (3.4% vs. 9.3%: OR 2.93; 95% CI 2.27–3.79). Patients with COPD and COVID-19 were significantly older (75 vs. 66 years), predominantly male (83% vs. 17%), smoked more frequently, and had more comorbidities than their non-COPD counterparts. Pneumonia was the most common diagnosis among COPD patients hospitalized due to COVID-19 (59%); 19% of patients showed pulmonary infiltrates suggestive of pneumonia and heart failure. Mortality in COPD patients with COVID-19 was associated with older age and prevalence of heart failure (p < 0.05). COPD patients with COVID-19 showed higher rates of hospitalization and mortality, mainly associated with pneumonia. This clinical profile is different from exacerbations caused by other respiratory viruses in the winter season. url: https://doi.org/10.3390/jcm9103259 doi: 10.3390/jcm9103259 id: cord-293852-r72c6584 author: Greco, S. title: Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era date: 2020-10-31 words: 8163.0 sentences: 468.0 pages: flesch: 40.0 cache: ./cache/cord-293852-r72c6584.txt txt: ./txt/cord-293852-r72c6584.txt summary: Different studies found that the values of cardiac Troponins were increased in COVID-19 patients with more severe disease [4, 5, [68] [69] [70] , indicating an association of SARS-CoV-2 with myocardial damage. Moreover, the single-cell RNA-sequencing (scRNAseq) approach has been used to profile the SARS-CoV-2 host-response in the PBMCs of COVID-19 patients, and to comprehensively characterize the immunological changes [124] [125] [126] [127] [128] [129] [130] . However, SARS-CoV-2 infection of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) induced cytotoxic effects and RNA-seq findings highlighted significant transcriptional changes in gene pathways related to cellular metabolism and immune response [131] [132] [133] . This analysis also revealed several host-derived lncRNAs differentially expressed in COVID-19 patient-derived lung tissue, and in SARS-CoV-2 infected epithelial cells, including MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) and NEAT1 (nuclear-enriched autosomal transcript 1) [151] (Fig. 5) . abstract: COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many patients also display acute myocardial injury and chronic damage to the cardiovascular system. Understanding both direct and indirect damage caused to the heart and the vascular system by SARS-CoV-2 infection is necessary to identify optimal clinical care strategies. The homeostasis of the cardiovascular system requires a tight regulation of the gene expression, which is controlled by multiple types of RNA molecules, including RNA encoding proteins (messenger RNAs) (mRNAs) and those lacking protein-coding potential, the noncoding-RNAs. In the last few years, dysregulation of noncoding-RNAs has emerged as a crucial component in the pathophysiology of virtually all cardiovascular diseases. Here we will discuss the potential role of noncoding RNAs in COVID-19 disease mechanisms and their possible use as biomarkers of clinical use. url: https://www.ncbi.nlm.nih.gov/pubmed/33129318/ doi: 10.1186/s12967-020-02582-8 id: cord-294969-57xgqf2g author: Green, Bart N. title: Rapid Deployment of Chiropractic Telehealth at 2 Worksite Health Centers in Response to the COVID-19 Pandemic: Observations from the Field date: 2020-06-11 words: 5987.0 sentences: 370.0 pages: flesch: 53.0 cache: ./cache/cord-294969-57xgqf2g.txt txt: ./txt/cord-294969-57xgqf2g.txt summary: Therefore, the purpose of this paper is to describe the rapid deployment of remote musculoskeletal care through telehealth, particularly using real time video conferencing, for chiropractic services integrated in 2 health centers located on 2 campuses of a large company in California. There were 3 distinct challenges to operationalizing remote RTVCs: (1) the chiropractors had to conduct their part of the visits from their homes; (2) the patients had to access visits from home; and (3) there was no direct contact with the interprofessional provider team, health center management, or technical support. The setting and context of the WSHC environment is a key part of how we have operationalized the use of chiropractic RTVCs. The interprofessional collaborative team that staffs the health center greatly facilitates the ability to transition rapidly from in-clinic care to RTVCs. The providers have a regular practice of working as a team. abstract: OBJECTIVE: The purpose of this paper is to describe the rapid deployment of telehealth, particularly real time video conference, for chiropractic services as a response to COVID-19. METHODS: Two health centers at 2 campuses of a large California corporation have chiropractic care integrated into physical medicine services. Care was suspended beginning on March 17, 2020 to prevent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among patients and staff. On March 19, the Governor of California issued a stay at home order. With musculoskeletal problems being common in the employee patient population, telehealth services were quickly developed to continue chiropractic care for patients. Using existing infrastructure, several members of the health center team developed chiropractic telehealth operations within 2 days. RESULTS: Musculoskeletal telehealth services included examinations, risk assessment, advice, and rehabilitative exercises. These telehealth visits facilitated care that would have otherwise been unavailable to employees. Patients reported that the appointments were helpful, addressed their concerns, and provided a safe method to see their doctor. Regular interprofessional teamwork and relations between the clinic operator and client company were key contributors to operationalizing this service in our integrated healthcare environment. CONCLUSION: We were able to quickly implement real time video conferencing and other forms of telehealth for chiropractic services at 2 worksite health centers. This paper includes information and insights to providers about setting up similar telehealth systems so they may also provide this benefit for patients in their communities during pandemics or disasters. url: https://doi.org/10.1016/j.jmpt.2020.05.008 doi: 10.1016/j.jmpt.2020.05.008 id: cord-311942-oju4gosw author: Grewal, Parneet title: Acute Ischemic Stroke and COVID-19: Experience From a Comprehensive Stroke Center in Midwest US date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: COVID-19 has been associated with increased risk of venous and arterial thromboembolism including ischemic stroke. We report on patients with acute ischemic stroke and concomitant COVID-19 in a diverse patient population. Methods: This is a retrospective analysis of patients hospitalized with acute ischemic stroke (AIS) and COVID-19 to our comprehensive stroke center in Chicago, IL, between March 1, 2020, and April 30, 2020. We reviewed stroke characteristics, etiologies, and composite outcomes. We then compared our cohort with historic patients with AIS without COVID-19 admitted in the same time frame in 2019 and 2020. Results: Out of 13 patients with AIS and COVID-19, Latinos and African-Americans compromised the majority of our cohort (76.8%), with age ranging from 31–80 years. Most strokes were cortical (84.6%) and more than 50% of patients had no identifiable source, and were categorized as embolic stroke of unknown source (ESUS). A trend toward less alteplase administration was noted in the COVID-19 stroke patients compared to the non-COVID group from 2020 and 2019 (7.1 vs. 20.7% p 0.435 and 7.1 vs. 27.2% p 0.178). Endovascular thrombectomy was performed in 3 (23%) patients. Systemic thrombotic complications occurred in 3 (23%) COVID-19 AIS patients. Median National Institutes of Health Stroke Scale and modified Rankin Scale at discharge were 11 (IQR 4–23) and 4 (IQR 3–4), respectively. In the logistic regression model corrected for age and sex, COVID-19 was associated with discharge to mRS > 2 (p 0.046, OR 3.82, CI 1.02–14.3). Eight patients (63.8%) were discharged home or to acute rehabilitation, and two deceased from COVID-19 complications. Conclusion: AIS in the setting of COVID-19 is associated with worse outcomes, especially among African-American and Latino populations. Large vessel disease with ESUS was common suggesting an increased risk of coagulopathy and endothelial dysfunction as a potential etiology. url: https://doi.org/10.3389/fneur.2020.00910 doi: 10.3389/fneur.2020.00910 id: cord-035182-ax6v3ak5 author: Griebenow, Reinhard title: Outcomes in CME/CPD - Special Collection: How to make the “pyramid” a perpetuum mobile date: 2020-10-27 words: 2781.0 sentences: 165.0 pages: flesch: 45.0 cache: ./cache/cord-035182-ax6v3ak5.txt txt: ./txt/cord-035182-ax6v3ak5.txt summary: To enhance the effect CME may achieve in improving community health the authors suggest a kick-off/keep-on continuum of medical competence, and integration of aspects of public health at all levels from planning to delivery and outcomes measurement in CME. Continuing medical education (CME) should not be an end in itself, but as expressed in Moore''s pyramid [1] , help to improve both individual patient and ultimately community health. Continuing medical education (CME) should not be an end in itself, but as expressed in Moore''s pyramid [1] , help to improve both individual patient and ultimately community health. On the one hand there is some evidence for the impact of this strategy on physician performance and patient outcomes [82] , but on the other hand this is not the appropriate strategy to address gaps in community health, and tends to create an attitude of unbalanced activism. The impact of CME on physician performance and patient health outcomes: an updated synthesis of systematic reviews abstract: Continuing medical education (CME) should not be an end in itself, but as expressed in Moore’s pyramid, help to improve both individual patient and ultimately community, health. However, there are numerous barriers to translation of physician competence into improvements in community health. To enhance the effect CME may achieve in improving community health the authors suggest a kick-off/keep-on continuum of medical competence, and integration of aspects of public health at all levels from planning to delivery and outcomes measurement in CME. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599014/ doi: 10.1080/21614083.2020.1832750 id: cord-254852-qr5gdmbc author: Grief, Samuel N. title: Guidelines for the Evaluation and Treatment of Pneumonia date: 2018-08-14 words: 4731.0 sentences: 300.0 pages: flesch: 39.0 cache: ./cache/cord-254852-qr5gdmbc.txt txt: ./txt/cord-254852-qr5gdmbc.txt summary: A 2015 prospective, multi-center study by the Centers for Disease Control and Prevention identified a responsible pathogen in only 38% of cases of community-acquired pneumonia (CAP) in adults requiring hospitalization. 13 However, more extensive diagnostic testing should be considered in patients who are at risk for infection with unusual pathogens, who are not responding to treatment, or when additional testing is likely to change antibiotic management (Table 3) . Their analysis of 13 randomized controlled trials found significantly decreased mortality in severe pneumonia, decreased need for mechanical ventilation, decreased occurrence of acute respiratory distress syndrome, decreased time to clinical stability, and shorter duration of hospitalization. Elderly patients with pneumonia may not exhibit typical symptoms or physical examination findings seen in younger adults, such as pleuritic chest pain, cough, fever, and leukocytosis. Impact of inappropriate antibiotic therapy on mortality in patients with ventilator-associate pneumonia and blood stream infection: a meta-analysis abstract: Pneumonia is a common cause of respiratory infection, accounting for more than 800,000 hospitalizations in the United States annually. Presenting symptoms of pneumonia are typically cough, pleuritic chest pain, fever, fatigue, and loss of appetite. Children and the elderly have different presenting features of pneumonia, which include headache, nausea, abdominal pain, and absence of one or more of the prototypical symptoms. Knowledge of local bacterial pathogens and their antibiotic susceptibility and resistance profiles is the key for effective pharmacologic selection and treatment of pneumonia. url: https://www.ncbi.nlm.nih.gov/pubmed/30115336/ doi: 10.1016/j.pop.2018.04.001 id: cord-251957-luw8m3eq author: Griffin, Claire L. title: Aortic Disease in the Time of COVID: Repercussions on Patient Care at an Academic Aortic Center date: 2020-04-30 words: 1402.0 sentences: 76.0 pages: flesch: 50.0 cache: ./cache/cord-251957-luw8m3eq.txt txt: ./txt/cord-251957-luw8m3eq.txt summary: Here we describe the modifications we have implemented in clinical care provided by the 8 multidisciplinary Aortic Disease Program at our large regional referral institution to address the 9 challenges presented by the COVID-19 pandemic. Unfortunately given the rapid escalation of this worldwide pandemic, we do not 19 have the luxury of waiting for definitive data regarding the effects of COVID-19 on the 20 cardiovascular system-we must proceed in the face of this uncertainty to continue to take care 21 of patients. We have also considered altering our operative plan for patients with aortic disease in need of 13 high-risk operations to take into consideration the current and projected constrained resources of 14 our hospital system due to the pandemic. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During 17 the Coronavirus Disease 2019 (COVID-19) Pandemic abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32360374/ doi: 10.1016/j.jvs.2020.04.487 id: cord-259204-27t269pd author: Grimaldi, D. title: Characteristics and outcomes of Acute Respiratory Distress Syndrome related to COVID-19 in Belgian and French Intensive Care Units according to antiviral strategies. The COVADIS multicenter observational study. date: 2020-07-07 words: 3871.0 sentences: 223.0 pages: flesch: 50.0 cache: ./cache/cord-259204-27t269pd.txt txt: ./txt/cord-259204-27t269pd.txt summary: Background Limited data are available for antiviral therapy efficacy especially for the most severe patients under mechanical ventilation suffering from Covid-19 related Acute Respiratory Distress Syndrome (ARDS). Methods Observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, comparing antiviral strategies (none, hydroxychloroquine (HCQ), lopinavir/ritonavir (L/R), others (combination or remdesivir). Limited data are available for antiviral therapy efficacy especially for the most severe patients under mechanical ventilation suffering from Covid-19 related Acute Respiratory Distress Syndrome (ARDS). Observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, comparing antiviral strategies (none, hydroxychloroquine (HCQ), lopinavir/ritonavir (L/R), others (combination or remdesivir). In moderate to severe ARDS COVID-19 patients, we did not observe an association between treatment with hydroxychloroquine or lopinavir/ritonavir and ventilatory free days as compared to no antiviral treatment. abstract: Background Limited data are available for antiviral therapy efficacy especially for the most severe patients under mechanical ventilation suffering from Covid-19 related Acute Respiratory Distress Syndrome (ARDS). Methods Observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, comparing antiviral strategies (none, hydroxychloroquine (HCQ), lopinavir/ritonavir (L/R), others (combination or remdesivir). The primary end-point was the day-28 ventilator free days (VFD), patients which died before d28 were considered as having 0 VFD. The variable was dichotomized in patients still ventilated or dead at day 28 vs patients being extubated and alive at day 28 (VFD = or > 0). Results We analyzed 376 patients (80 with standard of care (SOC), 49 treated with L/R, 197 with HCQ, and 50 others). The median number of d28-VFD was 0 (IQR 0-13) and was different across the different groups (P=0.01), the SOC patients having the highest d28-VFD. A multivariate logistic regression including antiviral strategies, showed that age (OR 0.95 CI95%:0.93-0.98), male gender (OR 0.53 CI95%:0.31-0.93), Charlson score (OR 0.85 CI95%:0.73-0.99) and plateau pressure (OR 0.94 CI95%:0.88-0.99) were associated with having 0 d28-VFD whereas P/F ratio (OR 1.005 CI95%:1.001-1.010) was associated with having > or = 1 d28-VFD (ie. being extubated and alive). Acute kidney injury (AKI) was frequent (64%), its incidence was different across the patients groups (P=0.01). In a post-hoc logistic multivariate regression apart from demographics characteristics and comorbidities, the use of L/R (administered to 81 of 376 patients) was associated with occurrence of AKI (OR 2.07 CI95%:1.17-3.66) and need for renal replacement therapy (RRT). Conclusion In this observational study of moderate to severe Covid-19 ARDS patients, we did not observed a benefit of treating patients with any specific antiviral treatment. We observed an association between L/R treatment and occurrence of AKI and need for RRT. url: https://doi.org/10.1101/2020.06.28.20141911 doi: 10.1101/2020.06.28.20141911 id: cord-355898-hlkwwaqe author: Grippo, Antonello title: Electroencephalography during SARS-CoV-2 outbreak: practical recommendations from the task force of the Italian Society of Neurophysiology (SINC), the Italian League Against Epilepsy (LICE), and the Italian Association of Neurophysiology Technologists (AITN) date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: During COVID-19 lockdown, non-urgent medical procedures were suspended. Grade of urgency of electroencephalography (EEG) may vary according to the clinical indication, setting, and status of infection of SARS-CoV-2 virus. “Italian Society of Clinical Neurophysiology” (SINC), “Italian League Against Epilepsy” (LICE), and the “Italian Association of Neurophysiology Technologists” (AITN) aimed to provide clinical and technical recommendation for EEG indications and recording standards in this pandemic era. METHODS: Presidents of SINC, LICE, and AITN endorsed three members per each society to formulate recommendations: classification of the degree of urgency of EEG clinical indications, management and behavior of physicians and neurophysiology technologists, hygiene and personal protection standards, and use of technical equipment. RESULTS: Scientific societies endorsed a paper conveying the recommendation for EEG execution in accordance with clinical urgency, setting (inpatients/outpatients), status of SARS-CoV-2 virus infection (positive, negative and uncertain), and phase of governmental restrictions (phase 1 and 2). Briefly, in phase 1, EEG was recommended only for those acute/subacute neurological symptoms where EEG is necessary for diagnosis, prognosis, or therapy. Outpatient examinations should be avoided in phase 1, while they should be recommended in urgent cases in phase 2 when they could prevent an emergency room access. Reduction of staff contacts must be encouraged through rescheduling job shifts. The use of disposable electrodes and dedicated EEG devices for COVID-19-positive patients are recommended. CONCLUSIONS: During the different phases of COVID-19 pandemic, the EEG should be reserved for patients really benefiting from its execution in terms of diagnosis, treatment, prognosis, and avoidance of emergency room access. url: https://doi.org/10.1007/s10072-020-04585-1 doi: 10.1007/s10072-020-04585-1 id: cord-280628-ok62havd author: Groß, Sonja title: SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications date: 2020-04-30 words: 4453.0 sentences: 252.0 pages: flesch: 43.0 cache: ./cache/cord-280628-ok62havd.txt txt: ./txt/cord-280628-ok62havd.txt summary: COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS-CoV-2 while gaining time to explore and improve treatment options especially for cardiovascular disease (CVD) and immunocompromised patients, who appear to be at high-risk to die from cardiopulmonary failure. Since the coronavirus disease (COVID19) is still an emerging pandemic with more than 2.1 million confirmed cases worldwide [1] , special focus is currently directed towards the understanding of why people are hospitalized, receive intensive care, and frequently die as a consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. While higher mortality rates among CVD patients are also associated with other respiratory diseases (especially influenza virus-induced flu or previous SARS epidemics), the question was put forward, whether people treated for heart-related illness are more prone to SARS-CoV-2 viral infection, based on first epidemiological evidence, but particularly based on the presumed upregulation of the SARS-CoV-2 entry receptor. abstract: The current COVID-19 pandemic started several months ago and is still exponentially growing in most parts of the world – this is the most recent and alarming update. COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS-CoV-2 while gaining time to explore and improve treatment options especially for cardiovascular disease (CVD) and immunocompromised patients, who appear to be at high-risk to die from cardiopulmonary failure. Currently unanswered questions are why elderly people, particularly those with pre-existing comorbidities seem to exhibit higher mortality rates after SARS-CoV-2 infection and whether intensive care becomes indispensable for these patients to prevent multi-organ failure and sudden death. To face these challenges, we here summarize the molecular insights into viral infection mechanisms and implications for cardiovascular disease. Since the infection starts in the upper respiratory system, first flu-like symptoms develop that spread throughout the body. The wide range of affected organs is presumably based on the common expression of the major SARS-CoV-2 entry-receptor angiotensin-converting enzyme 2 (ACE2). Physiologically, ACE2 degrades angiotensin II, the master regulator of the renin-angiotensin-aldosterone system (RAAS), thereby converting it into vasodilatory molecules, which have well-documented cardio-protective effects. Thus, RAAS inhibitors, which may increase the expression levels of ACE2, are commonly used for the treatment of hypertension and CVD. This, and the fact that SARS-CoV-2 hijacks ACE2 for cell-entry, have spurred controversial discussions on the role of ACE2 in COVID-19 patients. In this review, we highlight the state-of-the-art knowledge on SARS-CoV-2-dependent mechanisms and the potential interaction with ACE2 expression and cell surface localization. We aim to provide a list of potential treatment options and a better understanding of why CVD is a high risk factor for COVID-19 susceptibility and further discuss the acute as well as long-term cardiac consequences. url: https://www.ncbi.nlm.nih.gov/pubmed/32360703/ doi: 10.1016/j.yjmcc.2020.04.031 id: cord-354103-4dldgqzf author: Grubic, Andrew D title: COVID-19 outbreak and surgical practice: The rationale for suspending non-urgent surgeries and role of testing modalities date: 2020-06-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: One-hundred years after the 1918-19 H1N1 flu pandemic and 10 years after the 2009 H1N1 flu pandemic, another respiratory virus has now inserted itself into the human population. Severe acute respiratory syndrome coronavirus has become a critical challenge to global health with immense economic and social disruption. In this article we review salient aspects of the coronavirus disease 2019 (COVID-19) outbreak that are relevant to surgical practice. The emphasis is on considerations during the pre-operative and post-operative periods as well as the utility and limitations of COVID-19 testing. The focus of the media during this pandemic is centered on predictive epidemiologic curves and models. While epidemiologists and infectious disease physicians are at the forefront in the fight against COVID-19, this pandemic is also a “stress test” to evaluate the capacity and resilience of our surgical community in dealing with the challenges imposed to our health system and society. As recently pointed out by Dr. Anthony Fauci, the virus decides the timelines in the models. However, the models can also change based on our decisions and behavior. It is our role as surgeons, to make every effort to bend the curves against the virus’ will. url: https://doi.org/10.4240/wjgs.v12.i6.259 doi: 10.4240/wjgs.v12.i6.259 id: cord-294527-fct2y5vn author: Guadarrama-Ortiz, Parménides title: Neurological Aspects of SARS-CoV-2 Infection: Mechanisms and Manifestations date: 2020-09-04 words: 8820.0 sentences: 441.0 pages: flesch: 37.0 cache: ./cache/cord-294527-fct2y5vn.txt txt: ./txt/cord-294527-fct2y5vn.txt summary: The human infection of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health emergency of international concern that has caused more than 16.8 million new cases and 662,000 deaths as of July 30, 2020. Although coronavirus disease 2019 (COVID-19), which is associated with this virus, mainly affects the lungs, recent evidence from clinical and pathological studies indicates that this pathogen has a broad infective ability to spread to extrapulmonary tissues, causing multiorgan failure in severely ill patients. In this context, SARS-CoV-2 can also cause viral meningitis and encephalitis, as demonstrated by a recent report of a 64-yearold patient with laboratory-confirmed COVID-19 who presented neurologic manifestations during the infection, including lethargy, clonus, and pyramidal signs in the lower limbs as well as stiff neck and Brudzinski sign (76) . Future studies are required to evaluate the serologic features of anti-glycolipid antibodies in patients with COVID-19 to elucidate possible mechanisms underlying the association between SARS-CoV-2 infection and Guillain-Barré syndrome. abstract: The human infection of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health emergency of international concern that has caused more than 16.8 million new cases and 662,000 deaths as of July 30, 2020. Although coronavirus disease 2019 (COVID-19), which is associated with this virus, mainly affects the lungs, recent evidence from clinical and pathological studies indicates that this pathogen has a broad infective ability to spread to extrapulmonary tissues, causing multiorgan failure in severely ill patients. In this regard, there is increasing preoccupation with the neuroinvasive potential of SARS-CoV-2 due to the observation of neurological manifestations in COVID-19 patients. This concern is also supported by the neurotropism previously documented in other human coronaviruses, including the 2002–2003 SARS-CoV-1 outbreak. Hence, in the current review article, we aimed to summarize the spectrum of neurological findings associated with COVID-19, which include signs of peripheral neuropathy, myopathy, olfactory dysfunction, meningoencephalitis, Guillain-Barré syndrome, and neuropsychiatric disorders. Furthermore, we analyze the mechanisms underlying such neurological sequela and discuss possible therapeutics for patients with neurological findings associated with COVID-19. Finally, we describe the host- and pathogen-specific factors that determine the tissue tropism of SARS-CoV-2 and possible routes employed by the virus to invade the nervous system from a pathophysiological and molecular perspective. In this manner, the current manuscript contributes to increasing the current understanding of the neurological aspects of COVID-19 and the impact of the current pandemic on the neurology field. url: https://doi.org/10.3389/fneur.2020.01039 doi: 10.3389/fneur.2020.01039 id: cord-262928-l2bqcd0l author: Guarisco, Gloria title: Covid-19 and diabesity: when a pandemia cross another pandemia date: 2020-07-14 words: 2040.0 sentences: 90.0 pages: flesch: 45.0 cache: ./cache/cord-262928-l2bqcd0l.txt txt: ./txt/cord-262928-l2bqcd0l.txt summary: The collision between the Covid-19 pandemic and the current diabesity epidemic has highlighted that obese and diabetic patients have a worse prognosis due to the impairment of the immune response to infections and due to the mechanical limits that make the management of the hospitalized patients with severe obesity more difficult. The limitations imposed on accessibility to non-urgent care during the lockdown of "phase 1" of this pandemic have created the need to revolutionize clinical practice to meet the health demands of chronic and high-risk diseases such as obesity and diabetes. Extensive Chinese observational reports on confirmed Covid-19 cases indicated that among patients with the most severe form of disease the prevalence of diabetes was 12-16% [5] [6] [7] [8] . In a French study, the risk for invasive mechanical ventilation in patients with COVID-19 infection admitted to Intensive Treatment Unit was more than sevenfold higher for those with BMI > 35 compared with BMI < 25 kg/m 2 [14] . abstract: The Covid-19 epidemic is having a strong impact on the population with pre-existing chronic diseases. The collision between the Covid-19 pandemic and the current diabesity epidemic has highlighted that obese and diabetic patients have a worse prognosis due to the impairment of the immune response to infections and due to the mechanical limits that make the management of the hospitalized patients with severe obesity more difficult. The limitations imposed on accessibility to non-urgent care during the lockdown of "phase 1" of this pandemic have created the need to revolutionize clinical practice to meet the health demands of chronic and high-risk diseases such as obesity and diabetes. The use of technology and risk stratification to establish the priority of access to the treatments that we have been forced to undertake will be useful tools for a new phase of a more efficient and successful treatment of diabesity. url: https://www.ncbi.nlm.nih.gov/pubmed/32666376/ doi: 10.1007/s40519-020-00958-9 id: cord-314070-8qz23nn4 author: Gubbi, Sriram title: Catecholamine physiology and its implications in patients with COVID-19 date: 2020-10-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The risk factors for severe COVID-19 are diverse, yet closely resemble the clinical manifestations of catecholamine excess states (eg, hypertension, cardiovascular disease, immune dysregulation, and hyperglycaemia), suggesting a potentially common basis for disease. Unfortunately, severe illness (eg, respiratory failure, compromised cardiac function, and shock) incurred by COVID-19 hinders the direct study of catecholamines in these patients, especially among those on multiple medications or those on adrenaline or noradrenaline infusions, or both. Phaeochromocytoma and paraganglioma (PPGL) are tumours that secrete catecholamines, namely adrenaline and noradrenaline, often in excess. PPGL are well studied disease processes in which the effects of catecholamines are easily discernible and therefore their potential biochemical and physiological influences in patients with COVID-19 can be explored. Because catecholamines are expected to have a role in patients with critical illness, patients on vasopressor infusions, and patients who sustain some acute and chronic physical stresses, the challenges involved in the management of catecholamine excess states are directly relevant to the treatment of patients with COVID-19. In this Personal View, we discuss the complex interplay between catecholamines and COVID-19, and the management of catecholamine excess states, while referencing relevant insights derived from the study of PPGL. url: https://api.elsevier.com/content/article/pii/S2213858720303429 doi: 10.1016/s2213-8587(20)30342-9 id: cord-350904-wyg8ikph author: Gubernatorova, E.O. title: IL-6: relevance for immunopathology of SARS-CoV-2 date: 2020-05-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics. url: https://api.elsevier.com/content/article/pii/S1359610120301088 doi: 10.1016/j.cytogfr.2020.05.009 id: cord-344302-p0v6sl9x author: Gubitosa, James C title: COVID-19-Associated Acute Limb Ischemia in a Patient on Therapeutic Anticoagulation date: 2020-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been found to cause multiple complications across several organ systems in patterns not typically observed in previous iterations of the virus. Hemostatic mechanisms have been noted to be significantly altered in particular, resulting in a disseminated intravascular coagulation (DIC)-like picture with elements of coagulopathy as well as hypercoagulability. A 65-year-old man with hypertension, hyperlipidemia, prior tobacco use, chronic kidney disease, and diabetes presented from a correctional facility with hypoxia. The diagnosis of COVID-19 was confirmed. With his elevated D-dimer of >7,955 ng/mL (reference: 90-500 ng/mL) in the setting of COVID-19 and hypoxia, he was empirically started on therapeutic anticoagulation with enoxaparin. His oxygen requirements increased, mental status deteriorated, and platelets began falling, raising concern for heparin-induced thrombocytopenia versus DIC. Heparin products were discontinued in favor of a direct oral anticoagulant. He later became obtunded and unable to tolerate oral medications. Fondaparinux was initiated. Two days later, he was found to have acute limb ischemia of the right lower extremity. He underwent surgical thrombectomy but required an above-the-knee amputation the following day. Shortly after he died secondary to hypoxic respiratory failure. This case highlights the derangement of hemostatic mechanisms seen prominently in COVID-19 infection and raises questions as to appropriate anticoagulant choices to adequately prevent thrombosis. Thorough physical exams should be performed on all patients with COVID-19, taking into account this documented hypercoagulability. Further investigation is warranted into the use of heparin products as the anticoagulant of choice in these patients given observed deficiencies of antithrombin III (ATIII). url: https://www.ncbi.nlm.nih.gov/pubmed/33133825/ doi: 10.7759/cureus.10655 id: cord-324918-36om8n2d author: Guha, Chandana title: Suspension and resumption of kidney transplant programs during the COVID‐19 pandemic: perspectives from patients, caregivers and potential living donors‐a qualitative study date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Many countries have suspended kidney transplantation programs during the COVID‐19 pandemic because of concerns for patient safety and the shortage of healthcare resources. This study aimed to describe patient, family member and potential donor perspectives on the suspension and resumption of kidney transplant programs due to COVID‐19. METHODS: We conducted seven online focus groups involving 31 adult kidney transplant candidates (n=22), caregivers (n=4) and potential donors (n=5). Transcripts were analyzed thematically. RESULTS: We identified five themes: cascading disappointments and devastation (with subthemes of shattering hope, succumbing to defeat, regret and guilt); helplessness and vulnerability (fear of declining health, confronted by the threat of and change in dialysis, disconnected from healthcare, susceptibility to infective complications); stress from uncertainty (confusion from conflicting information, unable to forward plan), exacerbating burdens (incurring extra financial costs, intensifying caregiver responsibilities), and sustaining health through the delay (protecting eligibility, relying on social support, adapting to emerging modalities of care). CONCLUSIONS: During the suspension of kidney transplantation programs, patients felt medically vulnerable because of declining health, susceptibility to infection and reduced access to care. There is a need to address health vulnerabilities, disappointment, uncertainty and additional burdens arising from the suspension of kidney transplantation programs. url: https://www.ncbi.nlm.nih.gov/pubmed/32640048/ doi: 10.1111/tri.13697 id: cord-296562-3h2oqb9k author: Guillén, Lucía title: Preemptive interleukin-6 blockade in patients with COVID-19 date: 2020-10-08 words: 4874.0 sentences: 246.0 pages: flesch: 44.0 cache: ./cache/cord-296562-3h2oqb9k.txt txt: ./txt/cord-296562-3h2oqb9k.txt summary: In contrast to other respiratory viral infections like influenza, a major pathogenic mechanism implicated in severe clinical manifestations of COVID-19 is an aberrant host immune response resulting in an excessive cytokine and chemokine release known as "cytokine storm" or "cytokine release syndrome" 2,3 . In a sensitivity analysis including only the 55 patients with confirmed SARS-CoV-2 infection by RT-PCR, the significant variables in the adjusted multivariate model were a NLR > 2.55 (OR 5.26; 95% CI 1.02-25), higher Charlson comorbidity index (OR 1.56; 95% CI 1.04-2.34) per unit, and higher SOFA score (OR 5.05; 95% CI 1.10-23.24) (Supplementary Table 2 ). This biomarker reflects excessive inflammation and dysregulation of immune cells that play a central role in severity of disease in viral infections 23 , and has been associated with mortality in patients hospitalized with COVID-19 24 . www.nature.com/scientificreports/ four comorbidities are included in the Charlson index, and have been associated with higher disease severity in patients with COVID-19 31 . abstract: Excessive interleukin-6 signaling is a key factor contributing to the cytokine release syndrome implicated in clinical manifestations of COVID-19. Preliminary results suggest that tocilizumab, a humanized monoclonal anti-interleukin-6 receptor antibody, may be beneficial in severely ill patients, but no data are available on earlier stages of disease. An anticipated blockade of interleukin-6 might hypothetically prevent the catastrophic consequences of the overt cytokine storm. We evaluated early-given tocilizumab in patients hospitalized with COVID-19, and identified outcome predictors. Consecutive patients with initial Sequential-Organ-Failure-Assessment (SOFA) score < 3 fulfilling pre-defined criteria were treated with tocilizumab. Serial plasma biomarkers and nasopharyngeal swabs were collected. Of 193 patients admitted with COVID-19, 64 met the inclusion criteria. After tocilizumab, 49 (76.6%) had an early favorable response. Adjusted predictors of response were gender, SOFA score, neutrophil/lymphocyte ratio, Charlson comorbidity index and systolic blood pressure. At week-4, 56.1% of responders and 30% of non-responders had cleared the SARS-CoV-2 from nasopharynx. Temporal profiles of interleukin-6, C-reactive protein, neutrophil/lymphocyte ratio, NT-ProBNP, D-dimer, and cardiac-troponin-I differed according to tocilizumab response and discriminated final in-hospital outcome. No deaths or disease recurrences were observed. Preemptive therapy with tocilizumab was safe and associated with favorable outcomes in most patients. Biological and clinical markers predicted outcomes. url: https://doi.org/10.1038/s41598-020-74001-3 doi: 10.1038/s41598-020-74001-3 id: cord-265472-b1s4stvz author: Guimarães, Luísa Eça title: Vaccines, adjuvants and autoimmunity date: 2015-10-31 words: 14633.0 sentences: 821.0 pages: flesch: 40.0 cache: ./cache/cord-265472-b1s4stvz.txt txt: ./txt/cord-265472-b1s4stvz.txt summary: In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. We can infer that a similar response may be associated with different safety in relation to the development of autoimmune reactions to vaccines, particularly in the patients with genetic predisposition to an enhanced response to vaccine inoculation [85] . HSP was associated with seasonal influenza, influenza A (H1N1), pneumococcal and meningococcal disease, hepatitis A virus (HAV), HBV, anti-human papilloma virus (HPV) vaccines, and following multiple combinations of vaccines, such as typhoid, cholera and yellow fever [139, [171] [172] [173] . Hepatitis B vaccination and undifferentiated connective tissue disease: another brick in the wall of the autoimmune/inflammatory syndrome induced by adjuvants (Asia) abstract: Abstract Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards an autoimmune reaction. The diagnosis of a definite autoimmune disease and the occurrence of fatal outcome post-vaccination have been less frequently reported. Since vaccines are given to previously healthy hosts, who may have never developed the disease had they not been immunized, adverse events should be carefully accessed and evaluated even if they represent a limited number of occurrences. In this review of the literature, there is evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. Despite this, efforts to unveil the connection between the triggering of the immune system by adjuvants and the development of autoimmune conditions should be undertaken. Vaccinomics is a field that may bring to light novel customized, personalized treatment approaches in the future. url: https://api.elsevier.com/content/article/pii/S1043661815001711 doi: 10.1016/j.phrs.2015.08.003 id: cord-314537-8a1vqale author: Guo, Fuzheng title: An effective screening and management process in the outpatient clinic for patients requiring hospitalization during the COVID‐19 pandemic date: 2020-04-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We have described the screening and management process for patients who present to the out‐patient clinics in China. We believe that our study makes a significant contribution to the literature because we have little reliable literature to refer to with regard to the COVID‐19 pandemic and this protocol has been admirably efficient in China. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32314819/ doi: 10.1002/jmv.25916 id: cord-315834-ashjw2xs author: Guo, Lingxi title: Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score date: 2019-12-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: The aim of this study was to further clarify clinical characteristics and predict mortality risk among patients with viral pneumonia. METHODS: A total of 528 patients with viral pneumonia at RuiJin hospital in Shanghai from May 2015 to May 2019 were recruited. Multiplex real-time RT-PCR was used to detect respiratory viruses. Demographic information, comorbidities, routine laboratory examinations, immunological indexes, etiological detections, radiological images and treatment were collected on admission. RESULTS: 76 (14.4%) patients died within 90 days in hospital. A predictive MuLBSTA score was calculated on the basis of a multivariate logistic regression model in order to predict mortality with a weighted score that included multilobular infiltrates (OR = 5.20, 95% CI 1.41–12.52, p = 0.010; 5 points), lymphocyte ≤ 0.8(∗)10(9)/L (OR = 4.53, 95% CI 2.55–8.05, p < 0.001; 4 points), bacterial coinfection (OR = 3.71, 95% CI 2.11–6.51, p < 0.001; 4 points), acute-smoker (OR = 3.19, 95% CI 1.34–6.26, p = 0.001; 3 points), quit-smoker (OR = 2.18, 95% CI 0.99–4.82, p = 0.054; 2 points), hypertension (OR = 2.39, 95% CI 1.55–4.26, p = 0.003; 2 points) and age ≥60 years (OR = 2.14, 95% CI 1.04–4.39, p = 0.038; 2 points). 12 points was used as a cut-off value for mortality risk stratification. This model showed sensitivity of 0.776, specificity of 0.778 and a better predictive ability than CURB-65 (AUROC = 0.773 vs. 0.717, p < 0.001). CONCLUSION: Here, we designed an easy-to-use clinically predictive tool for assessing 90-day mortality risk of viral pneumonia. It can accurately stratify hospitalized patients with viral pneumonia into relevant risk categories and could provide guidance to make further clinical decisions. url: https://www.ncbi.nlm.nih.gov/pubmed/31849894/ doi: 10.3389/fmicb.2019.02752 id: cord-284365-g46myqe7 author: Guo, Qian title: Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study date: 2020-05-19 words: 4758.0 sentences: 229.0 pages: flesch: 47.0 cache: ./cache/cord-284365-g46myqe7.txt txt: ./txt/cord-284365-g46myqe7.txt summary: Using a mixed-method triangulation design (QUAN + QUAL), this study investigated and compared the mental status and inflammatory markers of 103 patients who, while hospitalized with mild symptoms, tested positive with COVID-19 and 103 matched controls that were COVID-19 negative. Results revealed that COVID-19 patients, when compared to non-COVID controls, manifested higher levels of depression (P < 0.001), anxiety (P < 0.001), and post-traumatic stress symptoms (P < 0.001). The Patient Health Questionnaire, 9-item version (PHQ-9) (Kroenke et al., 2001) , Generalized Anxiety Disorder Assessment 7-item version (GAD-7), Perceived Stress Scale, 10-item version (PSS-10) (Barbosa-Leiker et al., 2013a) , and the PTSD Checklist for DSM-5 (PCL-5) were used to assess the levels of psychological distress of all participants (Wortmann et al., 2016) . Compared with normal controls, patients with COVID-19 presented higher levels of depression, anxiety, and post-traumatic stress symptoms. abstract: Since the end of 2019, Corona Virus Disease 2019 (COVID-19) has been the cause of a worldwide pandemic. The mental status of patients with COVID-19 who have been quarantined and the interactions between their psychological distress and physiological levels of inflammation have yet to be analyzed. Using a mixed-method triangulation design (QUAN + QUAL), this study investigated and compared the mental status and inflammatory markers of 103 patients who, while hospitalized with mild symptoms, tested positive with COVID-19 and 103 matched controls that were COVID-19 negative. The severity of depression, anxiety, and post-traumatic stress symptoms (PTSS) was measured via an on-line survey. Using a convenience sampling technique, qualitative data were collected until the point of data saturation. In addition, a semi-structured interview was conducted among five patients with COVID-19. Peripheral inflammatory markers were also collected in patients, both at baseline and within ± three days of completing the on-line survey. Results revealed that COVID-19 patients, when compared to non-COVID controls, manifested higher levels of depression (P < 0.001), anxiety (P < 0.001), and post-traumatic stress symptoms (P < 0.001). A gender effect was observed in the score of “Perceived Helplessness”, the subscale of PSS-10, with female patients showing higher scores compared to male patients (Z = 2.56, P = 0.010), female (Z = 2.37, P = 0.018) and male controls (Z = 2.87, P = 0.004). Levels of CRP, a peripheral inflammatory indicator, correlated positively with the PHQ-9 total score (R = .37, P = 0.003, Spearman’s correlation) of patients who presented symptoms of depression. Moreover, the change of CRP level from baseline inversely correlated with the PHQ-9 total score (R = -0.31, P = 0.002), indicative of improvement of depression symptoms. Qualitative analysis revealed similar results with respect to patient reports of negative feelings, including fear, guilt, and helplessness. Stigma and uncertainty of viral disease progression were two main concerns expressed by COVID-19 patients. Our results indicate that significant psychological distress was experienced by hospitalized COVID-19 patients and that levels of depressive features may be related to the inflammation markers in these patients. Thus, we recommend that necessary measures should be provided to address depression and other psychiatric symptoms for COVID-19 patients and attention should be paid to patient perceived stigma and coping strategies when delivering psychological interventions. url: https://www.sciencedirect.com/science/article/pii/S0889159120306188?v=s5 doi: 10.1016/j.bbi.2020.05.038 id: cord-346987-fbqqf00i author: Guo, Yongwen title: Controls of SARS-CoV-2 transmission in orthodontic practice date: 2020-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: ABSTRACT The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has attracted worldwide concerns because of its high person-to-person infectivity and lethality, and it was labeled as a pandemic as the rapid increase of confirmed cases in most areas around the world became evident. The SARS-CoV-2 is mainly transmitted through respiratory droplets and close contact. There are also evidences of transmission through aerosols and digestive tracts. Since orthodontic treatment involves large population who need routine return-visits, it was significantly affected and suspended because of the COVID-19 pandemic and the shutdown of the dental clinics and hospitals. Although the spread of COVID-19 has been effectively controlled in China and many areas have gradually resumed work and classes, orthodontic participants are still under high risks of SARS-CoV-2 infection. This is due to the asymptomatic carriers of SARS-CoV-2 or patients in the incubation period may cause the cross infection between orthodontic practitioners and patients. The close proximity between the practitioners and the patients, and the generation of droplets and aerosols that contain saliva and blood during treatment further increase the risks of transmission. In this review, we summarized the preventive strategies for controls of SARS-CoV-2 transmission to protect both staffs and patients during the orthodontic practice. url: https://doi.org/10.1016/j.ajodo.2020.05.006 doi: 10.1016/j.ajodo.2020.05.006 id: cord-312748-9v2bmbod author: Guo, Zhen title: Anticoagulation Management in Severe COVID-19 Patients on Extracorporeal Membrane Oxygenation date: 2020-09-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To explore special coagulation characteristics and anticoagulation management in extracorporeal membrane oxygenation assisted patients with coronavirus disease 2019. DESIGN: This study is single center retrospective observation of a series of patients. PARTICIPANTS: Laboratory-confirmed severe COVID-19 patients who received venovenous ECMO support from January 20(th) to May 20(th), 2020. INTERVENTIONS: This study analyzed the anticoagulation management and monitoring strategies, bleeding complications, and thrombotic events during ECMO support. RESULTS: Eight of 667 confirmed COVID-19 patients received venovenous ECMO and had an elevated D-dimer before and during ECMO support. An ECMO circuit pack (oxygenator and tubing) was replaced a total of 13 times in all eight patients and coagulation related complications included oxygenator thrombosis (7/8), tracheal hemorrhage (5/8), oronasal hemorrhage (3/8), thoracic hemorrhage (3/8), bleeding at puncture sites (4/8), and cannulation site hemorrhage (2/8). CONCLUSIONS: Hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients are common and possibly increase the propensity for thrombotic events and failure of the oxygenator. Currently there is not enough evidence to support a more aggressive anticoagulation strategy. url: https://doi.org/10.1053/j.jvca.2020.08.067 doi: 10.1053/j.jvca.2020.08.067 id: cord-264180-0vd3tr9j author: Gupta, Anupam K title: Is It Safe to Perform Lung Surgery During the Coronavirus Pandemic? date: 2020-08-14 words: 1635.0 sentences: 107.0 pages: flesch: 61.0 cache: ./cache/cord-264180-0vd3tr9j.txt txt: ./txt/cord-264180-0vd3tr9j.txt summary: All patients who remained for at least one-day inpatient post-lung surgery were assessed to see if they had an increased incidence of coronavirus infection during the hospital stay or at the follow-up office visit. As of April 20, 2020, we have reported 55 cases requiring intensive care unit (ICU) care at our tertiary medical center Boca Raton Regional Hospital (400 bedded hospital) in Florida and over 250 coronavirus positive patients. From February 1, 2020, to April 14, 2020, the patients who underwent lung surgery were evaluated for the incidence of coronavirus infection during the hospital stay and on postoperative follow-up. Patients underwent surgery after triage and if they fulfilled guidelines set by the American College of Surgeons and hospital review board, so that hospital resources were not exhausted during an increasing number of COVID cases in our community. abstract: Background: Coronavirus disease (COVID-19) patients are rapidly growing in our community. Patients with compromised lungs and older age are supposedly at high risk of poor outcomes with COVID-19. We aimed to evaluate the COVID-19 impact on lung surgery during this pandemic at our hospital. Methodology: This is a retrospective study of all lung surgery patients at our hospital in Boca Raton over three months (February to April 2020). All patients who remained for at least one-day inpatient post-lung surgery were assessed to see if they had an increased incidence of coronavirus infection during the hospital stay or at the follow-up office visit. Results: A total of 44 patients underwent thoracic surgery. It was found that there was no incidence of coronavirus infection in these patients. Conclusion: With adequate precautions, older patients can undergo lung surgery during this pandemic. There was no incidence of COVID-19 found among the patients during the hospital stay or at the first follow-up in the office. Also, the postoperative course was not adversely affected. url: https://www.ncbi.nlm.nih.gov/pubmed/32944464/ doi: 10.7759/cureus.9749 id: cord-017309-pt27efu1 author: Gupta, G. S. title: Selectins and Associated Adhesion Proteins in Inflammatory disorders date: 2012-03-20 words: 25423.0 sentences: 1303.0 pages: flesch: 40.0 cache: ./cache/cord-017309-pt27efu1.txt txt: ./txt/cord-017309-pt27efu1.txt summary: Activation of endothelial cells (EC) with different stimuli induces the expression of E-and P-selectins, and other adhesion molecules (ICAM-1, VCAM-1), involved in their interaction with circulating cells. Accordingly, population studies have explored the association of ischaemic heart disease with gene polymorphisms of the inflammatory molecules: tumor necrosis factors (TNF) a and b, transforming growth factors (TGF) b1 and 2, P and E selectins, and platelet endothelial cell adhesion molecule (PECAM) 1. Endothelial dysfunction in type 2 diabetic patients is associated with inflammation, increased levels of circulating soluble adhesion molecules (VCAM-1 and E-selectin), and inducing production of ROS, and urinary albumin excretion (Potenza et al. The A 561 C polymorphism of E-selectin gene may be associated with disease progression in patients with chronic HBV infection and control the expression of plasma soluble levels, while the G 98 T polymorphism may be related to fibrotic severity in Chinese population (Wu et al. abstract: Inflammation is defined as the normal response of living tissue to injury or infection. It is important to emphasize two components of this definition. First, that inflammation is a normal response and, as such, is expected to occur when tissue is damaged. Infact, if injured tissue does not exhibit signs of inflammation this would be considered abnormal and wounds and infections would never heal without inflammation. Secondly, inflammation occurs in living tissue, hence there is need for an adequate blood supply to the tissues in order to exhibit an inflammatory response. The inflammatory response may be triggered by mechanical injury, chemical toxins, and invasion by microorganisms, and hypersensitivity reactions. Three major events occur during the inflammatory response: the blood supply to the affected area is increased substantially, capillary permeability is increased, and leucocytes migrate from the capillary vessels into the surrounding interstitial spaces to the site of inflammation or injury. The inflammatory response represents a complex biological and biochemical process involving cells of the immune system and a plethora of biological mediators. Cell-to-cell communication molecules such as cytokines play an extremely important role in mediating the process of inflammation. Inflammation and platelet activation are critical phenomena in the setting of acute coronary syndromes. An extensive exposition of this complex phenomenon is beyond the scope of this article (Rankin 2004). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121831/ doi: 10.1007/978-3-7091-1065-2_44 id: cord-293570-gh6ykmea author: Gupta, Rajib K. title: Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease: a report of 2 cases date: 2020-08-04 words: 3479.0 sentences: 201.0 pages: flesch: 52.0 cache: ./cache/cord-293570-gh6ykmea.txt txt: ./txt/cord-293570-gh6ykmea.txt summary: Renal biopsy findings in hospitalized COVID-19 patients presenting solely with acute kidney injury (AKI) have recently been described in published literature in few case reports. We herein describe two cases where the patients presented primarily with nephrotic syndrome with a temporal association with COVID-19; the two renal biopsies showed two different histologic lesions on light microscopy (at least on initial biopsy) with diffuse podocytopathy as the sole ultrastructural lesion for both cases. BP was controlled to 128/84 mmHg. Follow-up: Two subsequent COVID-19 RT-PCR tests came back negative on the 4th and the 5th of May. He was commenced on oral prednisone 60 mg a day on the 8th of May. Unfortunately, there was no response to high-dose steroids and the patient continued to have nephrotic-range proteinuria and worsening renal function. abstract: BACKGROUND: Coronavirus disease-2019 (COVID-19) is an ongoing pandemic which has affected over 12 million people across the globe. Manifestations in different organs systems are being reported regularly. Renal biopsy findings in hospitalized COVID-19 patients presenting solely with acute kidney injury (AKI) have recently been described in published literature in few case reports. The findings include diffuse acute tubular injury (ATI) along with the glomerular lesion of collapsing glomerulopathy (CG). However, nephrotic syndrome as the presenting complaint of COVID-19 has not been reported widely, neither has any other glomerular lesion other than CG. CASE PRESENTATION: We describe the kidney biopsy findings of two patients who had recent diagnoses of COVID-19 and presented with new-onset nephrotic syndrome. Renal biopsy in both patients showed ATI (as in previous reports) and distinct glomerular findings on light microscopy – that of minimal change disease (MCD) initially in one patient followed by CG in a subsequent biopsy and CG at the outset in the other patient. The electron microscopic findings in both patients were that of severe podocytopathy (diffuse and severe podocyte foot process effacement). CONCLUSION: Our cases highlight a novel clinical presentation of COVID-19 renal disease, not described before, that of new-onset nephrotic syndrome. While all published case reports describe CG as the glomerular pathology, we describe a non-CG pathology (MCD) in one of our cases, thereby adding to the repertoire of renal pathology described in association with COVID-19 patients. However, the exact mechanism by which podocyte injury or podocytopathy occurs in all such cases is still unknown. Optimal treatment options for these patients also remains unknown at this time. url: https://doi.org/10.1186/s12882-020-01970-y doi: 10.1186/s12882-020-01970-y id: cord-272154-nrm9ulj5 author: Gupta, Ravi title: Guidelines of the Indian Society for Sleep Research (ISSR) for Practice of Sleep Medicine during COVID-19 date: 2020-07-04 words: 5690.0 sentences: 354.0 pages: flesch: 54.0 cache: ./cache/cord-272154-nrm9ulj5.txt txt: ./txt/cord-272154-nrm9ulj5.txt summary: Under these circumstances, the Indian Society for Sleep Research (ISSR) created a task force to develop guidelines for the practice of sleep medicine, not only for the Indian environment but also for other countries that are affected by the COVID-19 pandemic. As sleep services resume operations, there is a need to find innovative ways to reduce contact with COVID-19 patients, follow personal protection guidelines, as well as social distancing. Indian Society for Sleep Research (ISSR) created a task force to develop guidelines for the practice of sleep medicine that are applicable not only to India but also to other countries that are affected by the COVID-19 pandemic. Various levels of sleep studies, telemedicine, and positive airway pressure (PAP) therapy are the major aspects, given emphasis by the task force group of ISSR in these guidelines. abstract: BACKGROUND: Sleep services are assigned a non-essential status during COVID-19. The American Academy of Sleep Medicine strongly urges sleep clinicians to continue postponing non-urgent care until a later date, if such a recommendation is made by state officials due to local conditions. At the same time, one cannot ignore the fact that sleep is important for people’s health and wellbeing. Therefore, to protect the health of the population, it is essential to find ways and means to continue the practice of sleep medicine even during the COVID-19 pandemic. METHOD: Social environment and work ethics in sleep clinics and sleep laboratories in Asia, Africa, and Latin America are different from those in the US. Under these circumstances, the Indian Society for Sleep Research (ISSR) created a task force to develop guidelines for the practice of sleep medicine, not only for the Indian environment but also for other countries that are affected by the COVID-19 pandemic. The task force examined documents regarding practice of sleep medicine and associated specialities during COVID-19 by various professional organizations and governmental authorities. The recommendations were examined for their applicability. Wherever gaps were identified, consensus was reached keeping in view the available evidences. OUTCOME AND RECOMMENDATIONS: The emphasis of the guidelines is on avoiding doctor to patient contact during the pandemic. Teleconsultation and other modes of audio-visuals can be used as modes for medical practice during the COVID-19 pandemic. However, in addition to the patient, the presence of a family member, or a reliable informant is recommended. Patients of most sleep disorders can be provided tele-aftercare service. ISSR guidelines also give a list of medications allowed to be prescribed during the first and the follow-up teleconsultation. Hospitals and clinics are slowly opening in India and many other countries. As sleep services resume operations, there is a need to find innovative ways to reduce contact with COVID-19 patients, follow personal protection guidelines, as well as social distancing. This article does discuss strategies for the safe conduct of Level 1 sleep studies. Home sleep testing, which had greater acceptance during the last few years, should be given more attention during the COVID-19 period. Once the decision to reopen the sleep laboratory and resume operations is made, the safety of the patients and office staff should become the major priority. The ISSR recommendation is to postpone and reschedule in-laboratory positive pressure therapy, but it mentions the considerations to be followed in emergency situations. At the same time, high clinical risk patients may be diagnosed on the basis of clinical findings, and without performing polysomnography or home sleep testing. However, at some point, there is a need to reinitiate the in-lab testing. In addition, daily assessment of the COVID-19 situation in the community, along with a review of the situation with local public health and the state health department is advised. url: https://doi.org/10.1007/s41782-020-00097-2 doi: 10.1007/s41782-020-00097-2 id: cord-335465-sckfkciz author: Gupta, Rishi K. title: Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study date: 2020-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The number of proposed prognostic models for COVID-19 is growing rapidly, but it is unknown whether any are suitable for widespread clinical implementation. METHODS: We independently externally validated the performance candidate prognostic models, identified through a living systematic review, among consecutive adults admitted to hospital with a final diagnosis of COVID-19. We reconstructed candidate models as per original descriptions and evaluated performance for their original intended outcomes using predictors measured at admission. We assessed discrimination, calibration and net benefit, compared to the default strategies of treating all and no patients, and against the most discriminating predictor in univariable analyses. RESULTS: We tested 22 candidate prognostic models among 411 participants with COVID-19, of whom 180 (43.8%) and 115 (28.0%) met the endpoints of clinical deterioration and mortality, respectively. Highest areas under receiver operating characteristic (AUROC) curves were achieved by the NEWS2 score for prediction of deterioration over 24 h (0.78; 95% CI 0.73–0.83), and a novel model for prediction of deterioration <14 days from admission (0.78; 0.74–0.82). The most discriminating univariable predictors were admission oxygen saturation on room air for in-hospital deterioration (AUROC 0.76; 0.71–0.81), and age for in-hospital mortality (AUROC 0.76; 0.71–0.81). No prognostic model demonstrated consistently higher net benefit than these univariable predictors, across a range of threshold probabilities. CONCLUSIONS: Admission oxygen saturation on room air and patient age are strong predictors of deterioration and mortality among hospitalised adults with COVID-19, respectively. None of the prognostic models evaluated here offered incremental value for patient stratification to these univariable predictors. url: https://doi.org/10.1183/13993003.03498-2020 doi: 10.1183/13993003.03498-2020 id: cord-263908-4ti8l2ea author: Gupta, Ritesh title: Diabetes and COVID-19: evidence, current status and unanswered research questions date: 2020-05-13 words: 3693.0 sentences: 201.0 pages: flesch: 46.0 cache: ./cache/cord-263908-4ti8l2ea.txt txt: ./txt/cord-263908-4ti8l2ea.txt summary: Similarly, despite the recognition of angiotensin converting enzyme 2 (ACE2) as the receptor for severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), and the role of ACE2 in lung injury; there are conflicting results with the use of angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) in these patients. There is a need to further study the natural course of COVID-19 in patients with diabetes and to understand the individual, regional and ethnic variations in disease prevalence and course. It is not known whether patients with diabetes with well-controlled blood glucose levels have an increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). While one study in China did not find any association of ACE inhibitor use with severity of disease, there was an increased mortality in patients with COVID-19 receiving ACE inhibitors and ARBs in another study [29, 30] . abstract: Patients with diabetes who get coronavirus disease 2019 (COVID-19) are at risk of a severe disease course and mortality. Several factors especially the impaired immune response, heightened inflammatory response and hypercoagulable state contribute to the increased disease severity. However, there are many contentious issues about which the evidence is rather limited. There are some theoretical concerns about the effects of different anti-hyperglycaemic drugs. Similarly, despite the recognition of angiotensin converting enzyme 2 (ACE2) as the receptor for severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), and the role of ACE2 in lung injury; there are conflicting results with the use of angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) in these patients. Management of patients with diabetes in times of restrictions on mobility poses some challenges and novel approaches like telemedicine can be useful. There is a need to further study the natural course of COVID-19 in patients with diabetes and to understand the individual, regional and ethnic variations in disease prevalence and course. url: https://doi.org/10.1038/s41430-020-0652-1 doi: 10.1038/s41430-020-0652-1 id: cord-329152-1ixylnny author: Gupta, Shaili title: Hospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System date: 2020-04-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The 2019–2020 pandemic Coronavirus Disease 2019 (COVID-19) has inundated hospital systems globally, as they prepare to accommodate surge of patients requiring advanced levels of care. Pandemic preparedness has not been this urgently and widely needed in the last several decades. According to epidemiologic predictions, the peak of this pandemic has still not been reached, and hospitals everywhere need to ensure readiness to care for more patients than they usually do, and safety for healthcare workers who strive to save lives. We share our hospital-wide rapid preparedness and response to COVID-19 to help provide information to other healthcare systems globally. url: https://doi.org/10.1080/00325481.2020.1761668 doi: 10.1080/00325481.2020.1761668 id: cord-339679-9hghy9pd author: Gurley, Emily S. title: Person-to-Person Transmission of Nipah Virus in a Bangladeshi Community date: 2007-07-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: An encephalitis outbreak was investigated in Faridpur District, Bangladesh, in April–May 2004 to determine the cause of the outbreak and risk factors for disease. Biologic specimens were tested for Nipah virus. Surfaces were evaluated for Nipah virus contamination by using reverse transcription–PCR (RT-PCR). Thirty-six cases of Nipah virus illness were identified; 75% of case-patients died. Multiple peaks of illness occurred, and 33 case-patients had close contact with another Nipah virus patient before their illness. Results from a case-control study showed that contact with 1 patient carried the highest risk for infection (odds ratio 6.7, 95% confidence interval 2.9–16.8, p<0.001). RT-PCR testing of environmental samples confirmed Nipah virus contamination of hospital surfaces. This investigation provides evidence for person-to-person transmission of Nipah virus. Capacity for person-to-person transmission increases the potential for wider spread of this highly lethal pathogen and highlights the need for infection control strategies for resource-poor settings. url: https://www.ncbi.nlm.nih.gov/pubmed/18214175/ doi: 10.3201/eid1307.061128 id: cord-005496-cnwg4dnn author: Gutierrez, Guillermo title: Artificial Intelligence in the Intensive Care Unit date: 2020-03-24 words: 5011.0 sentences: 235.0 pages: flesch: 40.0 cache: ./cache/cord-005496-cnwg4dnn.txt txt: ./txt/cord-005496-cnwg4dnn.txt summary: Whereas humans develop generalized concepts on the basis of just a few examples, training a machine learning algorithm requires large quantities of data. Other studies have been published describing the use of machine learning models in generating patient-specific risk scores for pulmonary emboli [30] , risk stratification of ARDS [31] , prediction of acute kidney injury in severely burned patients [32] and in general ICU populations [33] , prediction of volume responsiveness after fluid administration [34] and identification of patients likely to develop complicated Clostridium difficile infection [35] . evaluated several types of machine learning algorithms, including random forest, naïve Bayes, and AdaBoost on data recorded from 62 mechanically ventilated patients with or at risk of ARDS. Machine learning algorithms have been used to analyze data stored in electronic medical records to predict ICU mortality and length of stay. abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092485/ doi: 10.1186/s13054-020-2785-y id: cord-299489-6v225vte author: Gómez-Hernández, María Teresa title: TWICE LUCKY: ELDERLY PATIENT SURVIVING BOTH COVID-19 AND SERENDIPITOUS LUNG CARCINOMA date: 2020-07-25 words: 506.0 sentences: 32.0 pages: flesch: 48.0 cache: ./cache/cord-299489-6v225vte.txt txt: ./txt/cord-299489-6v225vte.txt summary: So that, before transferring the patient we performed a new PCR test with a negative result. Once here, since the patient had not complied the 14 days of individual isolation after discharge, a serologic test was ordered to verify if the infection was active or passed; the result was positive, but unfortunately there was no possibility to know about which kind of immunoglobulins was elevated (Ig G or Ig M) due to the lack of reactants. Until a few days ago, only urgent procedures and high priority oncological elective surgery in non-COVID-19 patients were performed and always balancing the risk of delaying therapy against the availability of hospital resources and potential exposure of COVID-19 on a case-bycase basis. In addition, whenever possible, the elective surgical activity has been transferred to COVID-free areas to avoid potential contracting intra-hospital infections. Since previous reports have revealed that there are asymptomatic patients infected with SARS-CoV-2 (4,5), all patients needing a surgical intervention should be tested. abstract: nan url: https://api.elsevier.com/content/article/pii/S0300289620302349 doi: 10.1016/j.arbres.2020.07.009 id: cord-282361-gje78nb1 author: Gökce, Mehmet İlker title: How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE–IAU multicenter collaborative cohort study date: 2020-05-20 words: 3248.0 sentences: 154.0 pages: flesch: 43.0 cache: ./cache/cord-282361-gje78nb1.txt txt: ./txt/cord-282361-gje78nb1.txt summary: In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic. Information on the type of the stone related conditions, management strategies, anesthesiologic evaluation, anesthesia methods, and any alterations related to COVID-19 pandemic was collected. Rate of preoperative testing, emergency procedures, conservative approaches and topical/regional anesthesia increased after 21 days. The primary end point of the study was to collect information on the type of the stone related conditions, management strategies, anesthesiologic evaluation, anesthesia methods, and any alterations related to COVID-19 pandemic. While some guidelines suggest PCR testing in suspicious cases, the guidelines for sections with a high likelihood of virus load, such as otolaryngology, suggest that it can be performed Fig. 2 Summary of preoperative additional testing, alteration in anesthesia method and stone related procedures in the European cohort in all patients [14] . abstract: Stone disease is a unique condition that requires appropriate management in a timely manner as it can result in both emergent conditions and long term effects on kidney functions. In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic. The data of 473 patients from 11 centers in 5 different countries underwent interventions for urinary stones during the Covid-19 pandemic was collected and analyzed retrospectively. Information on the type of the stone related conditions, management strategies, anesthesiologic evaluation, anesthesia methods, and any alterations related to COVID-19 pandemic was collected. During the preoperative anesthesia evaluation thorax CT was performed in 268 (56.7%) and PCR from nasopharyngeal swab was performed in 31 (6.6%) patients. General anesthesia was applied in 337 (71.2%) patients and alteration in the method of anesthesia was recorded in 45 (9.5%) patients. A cut-off value of 21 days was detected for the hospitals to adapt changes related to COVID-19. Rate of preoperative testing, emergency procedures, conservative approaches and topical/regional anesthesia increased after 21 days. The preoperative evaluation for management of urinary stone disease is significantly affected by COVID-19 pandemic. There is significant alteration in anesthesia methods and interventions. The optimal methods for preoperative evaluation are still unknown and there is discordance between different centers. It takes 21 days for hospitals and surgeons to adapt and develop new strategies for preoperative evaluation and management of stones. url: https://doi.org/10.1007/s00240-020-01193-8 doi: 10.1007/s00240-020-01193-8 id: cord-026653-094bk0t0 author: Gülsen, Askin title: Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events* date: 2020-06-24 words: 14002.0 sentences: 779.0 pages: flesch: 47.0 cache: ./cache/cord-026653-094bk0t0.txt txt: ./txt/cord-026653-094bk0t0.txt summary: This review will evaluate reports of allergic and substance-specific infusion reactions (IR), injection-site reactions (ISR), hypersensitivity reactions (HSR), urticaria, and anaphylaxis caused by BSs. The most common indications for the use of biologics in lung diseases are allergic and severe uncontrolled asthma. The Australian Public Assessment report and the FDA label did not observe an increase in the incidence of severe immunological and anaphylactic reactions related to the use of nintedanib [25, 26] . According to the recent BCCA Drug Manual, it was reported that HSR including anaphylaxis can develop in ≤ 1 % (severe < 1 %), IRs in 1 % (severe ≤ 1 %), and immune-mediated rash in 8-18 % ( severe ≤ 1 %) of patients [58] . The FDA''s 2019 label reported infusion-related reactions in 11-24 % of patients (placebo 7-18.0 %), acute urticaria in 1-2 %, acute HSRs in 1.5 %, pruritus in 4 %, and serious IRs and anaphylaxis in < 1 % [159] . abstract: Purpose: Biotechnological substances (BSs) are strongly relied upon to prevent rejection of transplanted organs, and to treat oncological, allergological, and other inflammatory diseases. Allergic reactions to partly foreign biologics can occur due to their potential immunogenicity. The severity of an immune response to a biological drug may range from no clinical significance to a severe, life-threatening anaphylactic reaction. Methods: Detailed searches were performed on Pubmed, Web of Science, and Google Scholar to include all available publications. In addition, the Food and Drug Administration, the European Medicines Agency, and British Columbia Cancer Agency Drug Manual databases were screened for hypersensitivity reaction (HSR), infusion reaction, injection site reaction, urticaria, and anaphylaxis for individual BSs. Results: Treatment with BSs can cause various types of HSR. These are mentioned in the literature with definitions such as allergic reactions, anaphylactoid reactions, anaphylaxis, HSR, infusion reactions, injection site reactions, cytokine release syndrome, and urticaria. Due to the overlap in signs and symptoms in the reported descriptions, it is not always possible to differentiate these reactions properly according to their pathomechanism. Similarly, many data reported as anaphylaxis actually describe severe anaphylactic reactions (grades III or IV). Conclusion: There is an urgent need for a simpler symptom- or system-based classification and scoring system to create an awareness for HSRs to BSs. A better understanding of the pathophysiology of HSRs and increased clinical experience in the treatment of side effects will provide timely control of unexpected reactions. As a result, immunotherapy with BSs will become safer in the future. Cite this as Gülsen A, Wedi B, Jappe U. Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events. Allergo J Int 2020; 29:97-125 https://doi.org/10.1007/s40629-020-00126-6 url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289641/ doi: 10.1007/s15007-020-2550-1 id: cord-288580-onzzpkye author: HALAÇLI, Burçin title: Critically ill COVID-19 patient date: 2020-04-21 words: 3805.0 sentences: 208.0 pages: flesch: 46.0 cache: ./cache/cord-288580-onzzpkye.txt txt: ./txt/cord-288580-onzzpkye.txt summary: This pandemic is accepted as a viral pneumonia pandemic not a simple flu, therefore, intensive care unit (ICU) admission, follow-up, and management of the critically ill patients with COVID-19 is extremely important. HFNO therapy and NIMV support may be applied in selected hypoxemic respiratory failure cases with proper PPE because of high risk of aerosol generation. However, these patients should be followed closely in terms of clinical deterioration, if no positive response is obtained in the first few hours (refractory hypoxemia, tachypnoea, tidal volume (Vt) > 9 mL/kg meaning increased minute ventilation and work of breathing). In the light of the data obtained from COVID-19 pandemic and hospital follow-up of these critically ill patients, the needfulness of intensive care units with well-organized structure and trained HCW, has emerged once again. Expert consensus on preventing nosocomial transmission during respiratory care for critically ill patients infected by 2019 novel coronavirus pneumonia abstract: Coronavirus disease 2019 (COVID-19) stands out as the major pandemic that we have experienced in the last century. As it affects every social structure, it brought the importance of intensive care support once again to the agenda of healthcare system after causing severe acute respiratory syndrome. The precautions to be taken against this virus, where our knowledge is extremely small, intensive care units take an indispensable place in pandemic planning. In this review, we aimed to emphasize the crucial points regarding intensive care management of COVID-19 patients, which we have written not only for intensivists but also for all healthcare professionals. url: https://www.ncbi.nlm.nih.gov/pubmed/32293831/ doi: 10.3906/sag-2004-122 id: cord-028328-5lews3uw author: Haas, Andrew R. title: COMMUNITY-ACQUIRED PNEUMONIA date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332233/ doi: 10.1016/b978-1-4160-3291-5.50082-2 id: cord-018408-ttae193b author: Haddad, Imad Y. title: Pneumonia and Empyema date: 2008-11-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123273/ doi: 10.1007/978-1-84800-925-7_17 id: cord-263046-3aerbonz author: Hadfield, James N. title: The Evolving COVID-19 Effect on Hip Fracture Patients date: 2020-06-15 words: 1311.0 sentences: 70.0 pages: flesch: 52.0 cache: ./cache/cord-263046-3aerbonz.txt txt: ./txt/cord-263046-3aerbonz.txt summary: Despite this, we have had outbreaks of COVID-19 infections in green zone wards, most notably in our elderly hip fracture patients who tested negative on admission but then became COVID positive in the days after surgery. Early observations and a departmental audit of hip fracture patients admitted during March and April of this year (surgically stabilised) demonstrated a trend to higher 30-day mortality in patients who subsequently tested COVID positive after surgery compared to those who did not. During the coronavirus pandemic, surgical teams operating on COVID-19 positive patients were subject to stringent personal protective equipment (PPE) protocols in theatre. Given the likely increased mortality associated with COVID-19, it is essential that we ensure vulnerable patient groups such as hip fractures continue to receive optimal care regardless of infection status. It can be concluded that patients who present to hospital with a hip fracture and have an initial positive COVID-19 test contracted the virus prior to admission. abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0020138320304903 doi: 10.1016/j.injury.2020.06.006 id: cord-004450-daxz9yhp author: Haeberle, Helene title: Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study date: 2020-03-04 words: 5848.0 sentences: 383.0 pages: flesch: 48.0 cache: ./cache/cord-004450-daxz9yhp.txt txt: ./txt/cord-004450-daxz9yhp.txt summary: Several preclinical studies have revealed a beneficial effect of iloprost on the control of pulmonary inflammation, and in a small number of patients with ARDS, iloprost treatment resulted in improved oxygenation. For safety reasons, after treatment of 100 patients (day 28 after last dose investigational medicinal product [IMP] Patient 100) within the study, an interim analysis for an increased risk for pulmonary hemorrhage ≥ grade III according to Common Terminology (Toxicity) Criteria for Adverse Events (CTCAE) Version 5.0 in the treatment (iloprost) arm will be performed and the results discussed with the Data and Safety Monitoring Board (DSMB). When possible, however, the patient or his legal representative is to be informed both in writing and verbally by the investigator before any study-specific procedure is Iloprost or NaCl 0.9% (control) X X X X X Clinical assessment including outcome X X X X X X X X X Laboratory testing X X X X X X X X Adverse/serious adverse event monitoring X X X X X X X Plasma biomarkers X X X X X X Barthel Index X X X X SOFA score X X X X X X X X Health-related questionnaire X VES X performed. abstract: BACKGROUND: Acute respiratory distress syndrome (ARDS) is caused by rapid-onset (within hours) acute inflammatory processes in lung tissue, and it is a life-threatening condition with high mortality. The treatment of ARDS to date is focused on the prevention of further iatrogenic damage of the lung rather than the treatment of the initial inflammatory process. Several preclinical studies have revealed a beneficial effect of iloprost on the control of pulmonary inflammation, and in a small number of patients with ARDS, iloprost treatment resulted in improved oxygenation. Therefore, we plan to conduct a large multicenter trial to evaluate the effect of iloprost on ARDS. METHODS: The Therapeutic Iloprost during ARDS trial (ThIlo trial) is a multicenter, randomized, single blinded, clinical phase II trial assessing the efficacy of inhaled iloprost for the prevention of the development and progression of ARDS in critically ill patients. One hundred fifty critically ill patients suffering from acute ARDS will be treated either by nebulized iloprost or NaCl 0.9% for 5 days. Blood samples will be drawn at defined time points to elucidate the serum levels of iloprost and inflammatory markers during treatment. Mechanical ventilation will be standardized. In follow-up visits at days 28 and 90 as well as 6 months after enrollment, functional status according to the Barthel Index and a health care-related questionnaire, and frailty (Vulnerable Elders Survey) will be evaluated. The primary endpoint is the improvement of oxygenation, defined as the ratio of PaO(2)/FiO(2). Secondary endpoints include 90-day all-cause mortality, Sequential Organ Failure Assessment scores during the study period up to day 90, the duration of mechanical ventilation, the length of intensive care unit (ICU) stay, ventilator-associated pneumonia, delirium, ICU-acquired weakness, and discharge localization. The study will be conducted in three university ARDS centers in Germany. DISCUSSION: The results of the ThIlo trial will highlight the anti-inflammatory effect of iloprost on early inflammatory processes during ARDS, resulting in the improvement of outcome parameters in patients with ARDS. TRIAL REGISTRATION: EUDRA-CT: 2016-003168-37. Registered on 12 April 2017. ClinicalTrials.gov: NCT03111212. Registered on 4 June 2017. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057516/ doi: 10.1186/s13063-020-4163-0 id: cord-258708-da6x5rxa author: Hafiane, Anouar title: SARS-CoV-2 and the cardiovascular system date: 2020-07-16 words: 4033.0 sentences: 253.0 pages: flesch: 43.0 cache: ./cache/cord-258708-da6x5rxa.txt txt: ./txt/cord-258708-da6x5rxa.txt summary: The coronavirus disease COVID-19 is a public health emergency caused by a novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In COVID-19, particular attention has been given to the role of angiotensin-(Ang) converting enzyme 2 (ACE2), and the binding site for SARS-CoV-2 cellular entry (3). One of the clinical features of patients infected with SARS-CoV-2 included abnormal features such as acute cardiac injury (12%) (22) . Significance of the SARS-CoV-2 infection in the CV system is reflected through incidences of acute myocardial injury, arrhythmias, ACS, sepsis, septic shock, viral myocarditis, and heart failure. Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection 19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection abstract: The coronavirus disease COVID-19 is a public health emergency caused by a novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 infection uses the angiotensin-converting enzyme 2 (ACE2) receptor, and typically spreads through the respiratory tract. Invading viruses can elicit an exaggerated host immune response, frequently leading to a cytokine storm that may be fueling some COVID-19 death. This response contributes to multi-organ dysfunction. Accumulating data points to an increased cardiovascular disease morbidity, and mortality in COVID-19 patients. This brief review explores potential available evidence regarding the association between COVID-19, and cardiovascular complications. url: https://api.elsevier.com/content/article/pii/S0009898120303430 doi: 10.1016/j.cca.2020.07.019 id: cord-016572-6fu5s89c author: Hage, Chadi A. title: Endemic mycosis date: 2005 words: 9004.0 sentences: 571.0 pages: flesch: 43.0 cache: ./cache/cord-016572-6fu5s89c.txt txt: ./txt/cord-016572-6fu5s89c.txt summary: All three illnesses occur in normal hosts, although histoplasmosis and coccidioidomycosis are also major opportunistic mycoses in patients with depressed cell-mediated immunity, and especially in patients with acquired immunodeficiency syndrome (AIDS) [4] , [5] . Histoplasmosis, blastomycosis and coccidioidomycosis are major T-cell opportunistic infections, as demonstrated by the very aggressive course seen in patients with AIDS, in whom T-cell deficiency is most severe. The most severe form of progressive disseminated histoplasmosis (PDH) occurs in patients with AIDS with profound T-cell dysfunction [21] . By that time, most patients have either recovered or have required other more invasive methods of diagnosis because of rapidly worsening disease There are two ways to make a rapid diagnosis of PDH, sampling and examination of likely infected tissue with the use of special stains and the use of the ultrasensitive assay for fungal antigens. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120910/ doi: 10.1007/0-387-23380-6_12 id: cord-330655-crfj5adf author: Haider, Asim title: COVID-19 and the Brain: Acute Encephalitis as a Clinical Manifestation date: 2020-10-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Central nervous system (CNS) viral infections result in the clinical syndromes of aseptic meningitis or encephalitis. Although the primary target of coronavirus disease 2019 (COVID-19) is the respiratory system, it is increasingly being recognized as a neuropathogen. The hallmark clinical feature is altered mental status, ranging from mild confusion to deep coma. Most patients with encephalopathy or encephalitis are critically ill. We present a case of COVID-19-related encephalitis who presented with acute delirium and new-onset seizures. The patient responded well to treatment with intravenous immunoglobulins and rituximab. url: https://doi.org/10.7759/cureus.10784 doi: 10.7759/cureus.10784 id: cord-346288-9to4sdfq author: Haimovich, A. title: Development and validation of the COVID-19 severity index (CSI): a prognostic tool for early respiratory decompensation date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective: The goal of this study was to create a predictive model of early hospital respiratory decompensation among patients with COVID-19. Design: Observational, retrospective cohort study. Setting: Nine-hospital health system within the Northeastern United States. Populations: Adult patients ([≥] 18 years) admitted from the emergency department who tested positive for SARS-CoV-2 (COVID-19) up to 24 hours after initial presentation. Patients meeting criteria for critical respiratory illness within 4 hours of arrival were excluded. Main outcome and performance measures: We used a composite endpoint of respiratory critical illness as defined by oxygen requirement beyond low-flow nasal cannula (e.g., non-rebreather mask, high-flow nasal cannula, bi-level positive pressure ventilation), intubation, or death within the first 24 hours of hospitalization. We developed predictive models using patient demographic and clinical data collected during those first 4 hours. Eight hospitals were used for development and internal validation (n=932) and 1 hospital for model external validation (n=240). Predictive variables were identified using an ensemble approach that included univariate regression, random forest, logistic regression with LASSO, Chi-square testing, gradient boosting information gain, and gradient boosting Shapley additive explanation (SHAP) values prior to manual curation. We generated two predictive models, a quick COVID-19 severity index (qCSI) that uses only exam and vital sign measurements, and a COVID-19 severity index (CSI) machine learning model. Using area under receiver operating characteristic (AU-ROC), precision-recall curves (AU-PRC) and calibration metrics, we compare the qCSI and CSI to three illness scoring systems: Elixhauser mortality score, qSOFA, and CURB-65. We present performance of qCSI and CSI on an external validation cohort. Results: During the study period from March 1, 2020 to April 27, 2020, 1,792 patients were admitted with COVID-19. Six-hundred and twenty patients were excluded based on age or critical illness within the first 4 hours, yielding 1172 patients in the final cohort. Of these patients, 144 (12.3%) met the composite endpoint within the first 24 hours. The qCSI (AU-ROC: 0.90 [0.85-0.96]) comprised of nasal cannula flow rate, respiratory rate, and minimum documented pulse oximetry outperformed the baseline models (qSOFA: 0.76 [0.69-0.85]; Elixhauser: 0.70 [0.62-0.80]; CURB-65: AU-ROC 0.66 [0.58-0.77]) and was validated on an external cohort (AU-ROC: 0.82). The machine learning-based CSI had superior performance on the training cohort (AU-ROC: 0.91 [0.86-0.97]), but was unlikely to provide practical improvements in clinical settings. Conclusions: A significant proportion of admitted COVID-19 patients decompensate within 24 hours of hospital presentation and these events are accurately predicted using respiratory exam findings within a simple scoring system. url: http://medrxiv.org/cgi/content/short/2020.05.07.20094573v1?rss=1 doi: 10.1101/2020.05.07.20094573 id: cord-259329-8pta6o6a author: Haimovich, Adrian title: Development and validation of the quick COVID-19 severity index (qCSI): a prognostic tool for early clinical decompensation date: 2020-07-21 words: 4823.0 sentences: 275.0 pages: flesch: 44.0 cache: ./cache/cord-259329-8pta6o6a.txt txt: ./txt/cord-259329-8pta6o6a.txt summary: The objective of this study was to derive a risk stratification tool to predict 24 hour respiratory decompensation in admitted patients with COVID-19. 12 Second, to aid healthcare providers in assessing illness severity in COVID-3 19 patients, we present predictive models of early respiratory failure during hospitalization and compare them to three benchmarks accessible using data in the electronic health record: the Elixhauser comorbidity index, 13 the quick sequential organ failure assessment (qSOFA), 14, 15 and the CURB-65 pneumonia severity score. This was a retrospective observational cohort study to develop a prognostic model of early respiratory decompensation in patients admitted from the emergency department with COVID-19. 1Consistent with clinical observations, we noted a significant rate of progression to critical respiratory illness within the first 24 hours of hospitalization in COVID-19 patients. abstract: Abstract Objective The goal of this study was to develop a prognostic tool of early hospital respiratory failure among emergency department (ED) patients admitted with COVID-19. Methods This was an observational, retrospective cohort study from a nine ED health system in the United States of admitted adult patients with SARS-CoV-2 (COVID-19) and a ≤ 6 L/min oxygen requirement. We sought to predict respiratory failure within 24 hours of admission as defined by oxygen requirement of ≥ 10 L/min, any high-flow device, non-invasive or invasive ventilation, or death. Predictive models were compared to the Elixhauser comorbidity index, quick serial organ failure assessment (qSOFA), and the CURB-65 pneumonia severity score. Results During the study period from March 1 to April 27, 2020, 1,792 patients were admitted with COVID-19, 620 (35%) of whom had respiratory failure in the ED. Of the remaining 1,172 admitted patients, 144 (12.3%) met the composite endpoint within the first 24 hours of hospitalization. Using area under receiver-operating characteristic curves, we compared the performance of a novel bedside scoring system, the quick COVID-19 severity index (qCSI) composed of respiratory rate, oxygen saturation, and oxygen flow rate (mean [95% CI]) (0.81 [0.73-0.89]), a machine- learning model, the COVID-19 severity index (0.76 [0.65-0.86]), to the Elixhauser mortality index (0.61 [0.51-0.70])), CURB-65 (0.50 [0.40-0.60]), and qSOFA (0.59 [0.50-0.68]). A low qCSI score (≤ 3) had a sensitivity of 0.79 [0.65- 0.93] and specificity of 0.78 [0.72-0.83] in predicting respiratory decompensation with a less than 5% risk of outcome in the validation cohort. Conclusions A significant proportion of admitted COVID-19 patients progress to respiratory failure within 24 hours of admission. These events are accurately predicted using bedside respiratory exam findings within a simple scoring system. url: https://www.sciencedirect.com/science/article/pii/S0196064420305886?v=s5 doi: 10.1016/j.annemergmed.2020.07.022 id: cord-289775-40bi87iz author: Haines, David E. title: Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety date: 2014-05-07 words: 28535.0 sentences: 1331.0 pages: flesch: 35.0 cache: ./cache/cord-289775-40bi87iz.txt txt: ./txt/cord-289775-40bi87iz.txt summary: The specific criteria for recredentialing are determined by each individual hospital, but should generally parallel the following recommendations: ABIM CCEP board certification and IBHRE certification are limited to 10 years; to stay current for CCEP, the physician must complete a series of CME and/or practice improvement activities 9 ; recertification examination for CCEP and CCDS are each required at 10-year intervals; to ensure that cognitive and technical skills are maintained, the physician''s clinical competence must be evaluated and documented on a regular basis; it is the responsibility of the medical staff credentialing committee to ensure that physicians perform the necessary number of evaluations and procedures needed to maintain their expertise 31 and also that they participate in regular CME activities. The procedure report should include, at minimum, all the following: the primary and secondary operators, the indication for the procedure, names and doses of any medications administered, catheter/pacing/ICD lead model and serial numbers, insertion sites and intracardiac destinations, findings and procedure performed, complications encountered, and fluoroscopic exposure (fluoroscopy time, radiation dose, and the dose-area product) by an Advanced Cardiac Life Support (ACLS)/Pediatric Advanced Life Support (PALS)-certified nurse. abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1547527114003348 doi: 10.1016/j.hrthm.2014.03.042 id: cord-000284-00rk8fb5 author: Hajjar, L. A. title: Severe novel influenza A (H1N1) infection in cancer patients date: 2010-05-28 words: 3714.0 sentences: 222.0 pages: flesch: 44.0 cache: ./cache/cord-000284-00rk8fb5.txt txt: ./txt/cord-000284-00rk8fb5.txt summary: Conclusions: H1N1 viral infection in patients with cancer can cause severe illness, resulting in acute respiratory distress syndrome and death. However, patients with comorbidities as cancer and chronic diseases may show a serious clinical presentation, characterized by respiratory failure with variable severity [6, 7] . In this study, we describe the clinical and pathological findings in critically ill patients with cancer and respiratory failure related to novel H1N1 infection admitted to original article an oncologic intensive care unit (ICU) in a reference cancer center in Sao Paulo, Brazil. We report the clinical and pathological findings from eight patients with cancer and severe H1N1 infection who were admitted to an oncologic ICU during the winter period of the 2009 pandemic in Sao Paulo, Brazil. The serious clinical presentation of the novel Influenza A (H1N1) infection in some cancer patients should be expected. abstract: Background: The natural history and consequences of severe H1N1 influenza infection among cancer patients are not yet fully characterized. We describe eight cases of H1N1 infection in cancer patients admitted to the intensive care unit of a referral cancer center. Patients and methods: Clinical data from all patients admitted with acute respiratory failure due to novel viral H1N1 infection were reviewed. Lung tissue was submitted for viral and bacteriological analyses by real-time RT-PCR, and autopsy was conducted on all patients who died. Results: Eight patients were admitted, with ages ranging from 55 to 65 years old. There were five patients with solid organ tumors (62.5%) and three with hematological malignancies (37.5%). Five patients required mechanical ventilation and all died. Four patients had bacterial bronchopneumonia. All deaths occurred due to multiple organ failure. A milder form of lung disease was present in the three cases who survived. Lung tissue analysis was performed in all patients and showed diffuse alveolar damage in most patients. Other lung findings were necrotizing bronchiolitis or extensive hemorrhage. Conclusions: H1N1 viral infection in patients with cancer can cause severe illness, resulting in acute respiratory distress syndrome and death. More data are needed to identify predictors of unfavorable evolution in these patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990816/ doi: 10.1093/annonc/mdq254 id: cord-255807-7goz1agp author: Hak, E. title: Conventional Influenza Vaccination Is Not Associated with Complications in Working-Age Patients with Asthma or Chronic Obstructive Pulmonary Disease date: 2003-04-15 words: 4312.0 sentences: 194.0 pages: flesch: 41.0 cache: ./cache/cord-255807-7goz1agp.txt txt: ./txt/cord-255807-7goz1agp.txt summary: By using a nested case-control design, the authors studied the effectiveness of the influenza vaccine in reducing severe and fatal complications in 4,241 and 5,966 primary care, working-age patients aged 18–64 years who had asthma or chronic obstructive pulmonary disease during the 1998–1999 and 1999–2000 influenza epidemics in the Netherlands. The risk of influenza-related morbidity and mortality during influenza epidemics is high (1) (2) (3) (4) , and nonexperimental studies have shown that vaccination against influenza prevents respiratory and cardiac complications during epidemics in elderly patients with chronic obstructive pulmonary disease (COPD) (5, 6) . We determined the occurrence of respiratory and cardiac morbidity during influenza periods and the clinical effectiveness of vaccination in reducing these complications in patients aged 18-64 years who had asthma or COPD by using a prospective, nested case-control design. abstract: By using a nested case-control design, the authors studied the effectiveness of the influenza vaccine in reducing severe and fatal complications in 4,241 and 5,966 primary care, working-age patients aged 18–64 years who had asthma or chronic obstructive pulmonary disease during the 1998–1999 and 1999–2000 influenza epidemics in the Netherlands. Patients developing fatal or nonfatal exacerbations of lung disease, pneumonia, congestive heart failure, or myocardial infarction during either epidemic were considered cases. For each case, four age- and sex-matched controls were randomly sampled, and patient records were reviewed. Conditional logistic regression and propensity scores were used to assess vaccine effectiveness after adjustment for confounding factors. In seasons one and two, respectively, 87% (47/54) and 85% (171/202) of the cases and 74% (155/210) and 75% (575/766) of the controls had been vaccinated. After adjustments, vaccination was not associated with reductions in complications (season one: odds ratio = 0.95, 95% confidence interval (CI): 0.26, 3.48; season two: odds ratio = 1.07, 95% CI: 0.59, 1.96; pooled odds ratio = 1.07, 95% CI: 0.63, 1.80). Because influenza vaccination appeared not to be associated with a clinically relevant reduction in severe morbidity, other measures need to be explored. url: https://www.ncbi.nlm.nih.gov/pubmed/12697573/ doi: 10.1093/aje/kwg027 id: cord-254269-x8vpnhd2 author: Hakim, Abraham A. title: Implications for the use of telehealth in surgical patients during the COVID-19 pandemic date: 2020-04-21 words: 1321.0 sentences: 81.0 pages: flesch: 50.0 cache: ./cache/cord-254269-x8vpnhd2.txt txt: ./txt/cord-254269-x8vpnhd2.txt summary: A review of the PubMed Central and Medline provides articles examining the role of telemedicine for preoperative, postoperative, and follow up evaluation of surgical patients encompassing the past two decades. We report the summarized findings of these studies, the financial and HIPAA considerations of using telemedicine, potential benefits, pitfalls and strategies for the utilization of telemedicine into the clinical practice of general surgery and its subspecialties during the COVID-19 pandemic. While surgery may not seem like it would lend itself to telehealth practices, multiple studies have shown it can be a viable modality for safe and effective surgical care as an alternative to in-office visits in the pre and post-operative periods. The implementation of telehealth during the COVID-19 pandemic helps anyone and everyone adhere to policies of social distancing and reduce exposure, particularly patients at high risk Current use of telemedicine for post-discharge surgical care: a systematic review abstract: The COVID-19 pandemic has brought rapid changes to the way care must be delivered to keep patients and providers safe while simultaneously managing limited resources. Multiple fields have used telemedicine to continue care while maintaining social distancing and quarantine practices in the pandemic. Presented in this paper is a review describing the application of telemedicine in caring for surgical patients, and methods for potential implications of telehealthcare for surgical patients during the COVID-19 pandemic. A review of the PubMed Central and Medline provides articles examining the role of telemedicine for preoperative, postoperative, and follow up evaluation of surgical patients encompassing the past two decades. Additionally, articles examining the financial and legal considerations of telemedicine, and the effect COVID-19 has had on the current legislature were included. We report the summarized findings of these studies, the financial and HIPAA considerations of using telemedicine, potential benefits, pitfalls and strategies for the utilization of telemedicine into the clinical practice of general surgery and its subspecialties during the COVID-19 pandemic. url: https://doi.org/10.1016/j.amjsurg.2020.04.026 doi: 10.1016/j.amjsurg.2020.04.026 id: cord-341234-2zgfcrwc author: Hallak, Jorge title: Concise practice recommendations for the provision of andrological services and assisted reproductive technology for male infertility patients during the SARS-CoV-2 in Brazil date: 2020-09-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1590/s1677-5538.ibju.2020.06.03 doi: 10.1590/s1677-5538.ibju.2020.06.03 id: cord-299881-weptfpa2 author: Halvachizadeh, Sascha title: The impact of SARS-CoV-2 (COVID-19) pandemic on trauma bay management and guideline adherence in a European level-one-trauma centre date: 2020-07-28 words: 3332.0 sentences: 179.0 pages: flesch: 45.0 cache: ./cache/cord-299881-weptfpa2.txt txt: ./txt/cord-299881-weptfpa2.txt summary: This study aims to work out potential adjustments of trauma bay algorithms during a global pandemic in order to reduce contamination and to increase safety for patients and medical personnel. In order to contain spreading of SARS Cov-2, the suggested recommendations of adjusting trauma bay protocols for severely injured patients include (1) minimizing trauma bay team members with direct contact to the patient; (2) reducing repeated examination as much as possible, with rationalized use of protective equipment; and (3) preventing potential secondary inflammatory insults. These guidelines include recommendations for the minimum number of required medical professionals in the trauma bay (e.g., anesthesiologists, traumatologist, neurosurgeons, nurses, technicians etc..), initial assessments according to Advanced Trauma Life Support (e.g., blood pressure measurements, respiratory rate, auscultation and examination of body regions, etc.), and settings around the trauma bay management, such as operation room or computer tomography availability [5, 6] . abstract: PURPOSE: SARS CoV-2 (COVID-19) represents a pandemic that has led to adjustments of routine clinical practices. The initial management in the trauma bay follows detailed international valid algorithms. This study aims to work out potential adjustments of trauma bay algorithms during a global pandemic in order to reduce contamination and to increase safety for patients and medical personnel. METHODS: This retrospective cohort study compared patients admitted to the trauma bay of one academic level-one trauma centre in March and April 2019 with patients admitted in March and April 2020. Based on these datasets, possible adjustments of the current international guidelines of trauma bay management were discussed. RESULTS: Group Pan (2020, n = 30) included two-thirds the number of patients compared with Group Ref (2019, n = 44). The number of severely injured patients comparable amongst these groups: mean injury severity score (ISS) was significantly lower in Group Pan (10.5 ± 4.4 points) compared with Group Ref (15.3 ± 9.2 points, p = 0.035). Duration from admission to whole-body CT was significantly higher in Group Pan (23.8 ± 9.4 min) compared with Group Ref (17.3 ± 10.7 min, p = 0.046). Number of trauma bay admissions decreased, as did the injury severity for patients admitted in March and April 2020. In order to contain spreading of SARS Cov-2, the suggested recommendations of adjusting trauma bay protocols for severely injured patients include (1) minimizing trauma bay team members with direct contact to the patient; (2) reducing repeated examination as much as possible, with rationalized use of protective equipment; and (3) preventing potential secondary inflammatory insults. CONCLUSION: Appropriate adjustments of trauma bay protocols during pandemics should improve safety for both patients and medical personnel while guaranteeing the optimal treatment quality. The above-mentioned proposals have the potential to improve safety during trauma bay management in a time of a global pandemic. url: https://doi.org/10.1007/s00264-020-04740-5 doi: 10.1007/s00264-020-04740-5 id: cord-345632-iha2c5zo author: Hamdy, Sherif M title: Management Strategies of Patients with Neuromyelitis Optica Spectrum Disorder During the COVID-19 Pandemic Era date: 2020-08-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The ongoing coronavirus (COVID-19) pandemic is a global health emergency of international concern and has affected management plans of many autoimmune disorders. Immunosuppressive and immunomodulatory therapies are pivotal in the management of neuromyelitis optica spectrum disorder (NMOSD), potentially placing patients at an increased risk of contracting infections such as COVID-19. The optimal management strategy of NMOSD during the COVID-19 era remains unclear. Here, however, we examined the evidence of NMOSD disease-modifying therapies (DMTs) use during the present period and highlighted different scenarios including treatment of relapses as well as initiation and maintenance of DMTs in order to optimize care of NMOSD patients in the COVID-19 era. url: https://doi.org/10.2147/tcrm.s261753 doi: 10.2147/tcrm.s261753 id: cord-281566-6v5zfue6 author: Hamilos, Daniel L. title: Host-microbial interactions in patients with chronic rhinosinusitis date: 2013-11-28 words: 11724.0 sentences: 629.0 pages: flesch: 37.0 cache: ./cache/cord-281566-6v5zfue6.txt txt: ./txt/cord-281566-6v5zfue6.txt summary: 12 Our group found that cultured airway epithelial cells from patients with CRSsNP had an exaggerated response to stimulation with the combination of double-stranded RNA (a Toll-like receptor [TLR] 3 agonist and surrogate for viral infection) plus cigarette smoke extract, with exaggerated production of RANTES and hBD-2. Ramanathan et al 3 showed that culturing human sinonasal epithelial cells in the presence of the T H 2 cytokines IL-4 or IL-13 for 36 hours reduced expression of antimicrobial innate immune genes by using real-time PCR, ELISA, and flow cytometry, including TLR9, hBD-2, and SP-A. This has been shown in cultured airway epithelial cells and dispersed T lymphocytes from NPs. Fungi are commonly detected in the attached mucus of sinus tissues in patients with CRS 47,165 and can induce eosinophil activation and degranulation. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells abstract: There has been considerable investigation of host-microbial interactions in patients with chronic rhinosinusitis (CRS) in hopes of elucidating mechanisms of disease and better treatment. Most attention has been paid to bacterial infection and potential underlying defects in innate immunity. Bacterial biofilm is present in most patients with CRS undergoing surgical intervention, and its presence is associated with more severe disease and worse surgical outcomes. A role for viral or fungal infection in patients with CRS is less clear. There is no evidence for a primary defect in mucociliary clearance in most patients with CRS. Decreased levels of certain antimicrobial proteins, most notably lactoferrin, have been found in sinus secretions, whereas levels of other antimicrobial proteins have been found to be normal. No primary defects in Toll-like receptors have been found in patients with CRS, although a 50% reduced expression of Toll-like receptor 9 was reported in patients with recalcitrant nasal polyps. A polymorphism in a bitter taste receptor was recently associated with refractory CRS and persistent Pseudomonas aeruginosa infection. A downregulation of innate immunity by maladaptive T(H)2 tissue inflammation has also been described in patients with recalcitrant nasal polyps, suggesting a link to persistent infection. To date, an effective means of restoring host-microbial balance and mitigating disease in patients with CRS remains elusive. url: https://www.ncbi.nlm.nih.gov/pubmed/24290275/ doi: 10.1016/j.jaci.2013.06.049 id: cord-029609-zh2ah34g author: Hamilton, Barbara C.S. title: Developing Perioperative Covid-19 Testing Protocols to Restore Surgical Services date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Leaders at UCSF offer insights from their experience in developing guidelines on SARS-CoV-2 testing to ensure patient and staff safety as they resume scheduling surgical procedures for non–Covid-19 conditions that had been put on hold as the coronavirus pandemic developed. In addition to addressing logistical matters, it is essential to involve key stakeholders in the process, and to ensure clear communication and guidance on when surgery is or is not appropriate and how to address differences of opinion. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371310/ doi: 10.1056/cat.20.0265 id: cord-329453-ry1diso2 author: Hammer, Mark M. title: Radiologist Reporting and Operational Management for Patients with Suspected COVID-19 date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Objective Evaluate adoption and outcomes of locally-designed reporting guidelines for patients with possible COVID-19. Methods We developed a departmental guideline for radiologists that specified reporting terminology and required communication for patients with imaging findings suggestive of COVID-19, based on patient test status and imaging indication. In this retrospective study, radiology reports completed 3/1/2020-5/3/2020 that mentioned COVID-19 were reviewed. Reports were divided into patients with known COVID-19, patients with “suspected” COVID-19 (having an order indication of respiratory or infectious signs or symptoms), and “unsuspected patients” (other order indications, e.g., trauma or non-chest pain). Primary outcome was percentage of COVID-19 reports using recommended terminology; secondary outcome was percentages of suspected and unsuspected patients diagnosed with COVID-19. Relationships between categorical variables were assessed with Fisher’s exact test. Results Among 77,400 total reports, 1,083 suggested COVID-19 based on imaging findings; 774 (71%) of COVID-19 reports used recommended terminology. Of 574 patients without known COVID-19 at time of interpretation, 345 (60%) were eventually diagnosed with COVID-19, including 61% (315/516) of suspected and 52% (30/58) of unsuspected patients. Nearly all (46/58) unsuspected patients were identified at CT. Discussion Radiologists rapidly adopted recommended reporting terminology for patients with suspected COVID-19. The majority of patients for whom radiologists raised concern for COVID-19 were subsequently diagnosed with the disease, including the majority of clinically unsuspected patients. Using unambiguous terminology and timely notification about previously unsuspected patients will become increasingly critical to facilitate COVID-19 testing and contact tracing as states begin to lift restrictions. url: https://www.ncbi.nlm.nih.gov/pubmed/32590015/ doi: 10.1016/j.jacr.2020.06.006 id: cord-351625-1we9wi1g author: Han, Huan title: Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients date: 2020-10-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread around the world. Persons with asymptomatic disease exhibit viral shedding, resulting in transmission, which presents disease control challenges. However, the clinical characteristics of these asymptomatic individuals remain elusive. We collected samples of 25 asymptomatic and 27 symptomatic COVID-19 patients. Viral titers of throat swabs were determined by quantitative reverse transcription-PCR (qRT-PCR). COVID-19 IgG and IgM were examined. Complete blood counts were determined, and serum biochemistry panels were performed. Cytokines, including gamma interferon (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), IL-4, IL-6, and IL-10 were evaluated. T cell, B cell, and NK cell counts were measured using flow cytometry. Although similar viral loads were detected, asymptomatic patients had significantly faster virus turnover than symptomatic patients. Additionally, asymptomatic patients had higher counts of lymphocytes, T cells, B cells, and NK cells. While liver damage was observed in symptomatic patients, as indicated by elevated liver enzymes and decreased liver-synthesized proteins in the blood, asymptomatic patients showed normal liver measurements. Lactate dehydrogenase, a COVID-19 risk factor, was significantly lower in asymptomatic patients. These results suggest that asymptomatic COVID-19 patients had normal clinical indicators and faster viral clearance than symptomatic patients. Lymphocytes may play a role in their asymptomatic phenotype. Since asymptomatic patients may be a greater risk of virus transmission than symptomatic patients, public health interventions and a broader range of testing may be necessary for the control of COVID-19. IMPORTANCE Asymptomatic transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a potential problem for pandemic control through public health strategies. Our results demonstrate that asymptomatic COVID-19 patients have better outcomes than symptomatic patients. This may have been due to more active cellular immune responses and normal liver function. Since asymptomatic patients have no clinical symptoms which can easily prevent timely diagnosis and treatment, they may cause a greater risk of virus transmission than symptomatic patients, which poses a major challenge to infection control. Evidence suggests that nonpharmaceutical public health interventions, like social distancing and face mask ordinances, play important roles in the control of COVID-19. Looking forward, it may be necessary to proceed cautiously while reopening businesses in areas of epidemicity to prevent potential waves of COVID-19 in the future. url: https://www.ncbi.nlm.nih.gov/pubmed/33028689/ doi: 10.1128/msphere.00922-20 id: cord-288102-iom6lu7o author: Han, Jing title: Analysis of factors affecting the prognosis of COVID-19 patients and viral shedding duration date: 2020-06-25 words: 4291.0 sentences: 226.0 pages: flesch: 51.0 cache: ./cache/cord-288102-iom6lu7o.txt txt: ./txt/cord-288102-iom6lu7o.txt summary: The clinical characteristics of patients with COVID-19 were analysed to determine the factors influencing the prognosis and virus shedding time to facilitate early detection of disease progression. The clinical characteristics of 185 patients with COVID-19 diagnosed in Tianjin were analysed retrospectively to determine the factors affecting their prognoses and the duration of viral shedding with the aim of facilitating early treatment and improving patient prognosis. We found that a lower PaO 2 /FiO 2 at the time of admission is a risk factor for a poor prognosis in patients with severe COVID-19. In our study, univariate analysis results showed that age was a risk factor for prolonged viral shedding duration, but no significant difference was found in the multivariate Cox analysis. This study showed that diabetes mellitus, age, the time from symptom onset to treatment and PaO 2 /FiO 2 can predict the prognosis of patients with COVID-19. abstract: The clinical characteristics of patients with COVID-19 were analysed to determine the factors influencing the prognosis and virus shedding time to facilitate early detection of disease progression. Logistic regression analysis was used to explore the relationships among prognosis, clinical characteristics and laboratory indexes. The predictive value of this model was assessed with receiver operating characteristic curve analysis, calibration and internal validation. The viral shedding duration was calculated using the Kaplan–Meier method, and the prognostic factors were analysed by univariate log-rank analysis and the Cox proportional hazards model. A retrospective study was carried out with patients with COVID-19 in Tianjin, China. A total of 185 patients were included, 27 (14.59%) of whom were severely ill at the time of discharge and three (1.6%) of whom died. Our findings demonstrate that patients with an advanced age, diabetes, a low PaO(2)/FiO(2) value and delayed treatment should be carefully monitored for disease progression to reduce the incidence of severe disease. Hypoproteinaemia and the fever duration warrant special attention. Timely interventions in symptomatic patients and a time from symptom onset to treatment <4 days can shorten the duration of viral shedding. url: https://doi.org/10.1017/s0950268820001399 doi: 10.1017/s0950268820001399 id: cord-004379-91a7sgir author: Han, Nayoung title: Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews date: 2020-02-20 words: 3261.0 sentences: 190.0 pages: flesch: 46.0 cache: ./cache/cord-004379-91a7sgir.txt txt: ./txt/cord-004379-91a7sgir.txt summary: The aim of this study was to evaluate age-related clinical manifestations of adverse events (AEs) related to NAIs. FAERS and WebMD data were downloaded. A disproportionality analysis showed that signals for vomiting and hallucinations were detected in younger patients given oseltamivir, while an abnormal hepatic function, cardiac failure, shock, and cardio-respiratory arrest were detected in older patients given peramivir. However, there is still concern regarding the adverse effects of NAIs. This study analyzed the age-related AEs associated with NAIs using data from FAERS and WebMD. Oseltamivir was the NAI most commonly showing AEs in the FAERS data, and the most common AEs for this drug were psychiatric and gastrointestinal disorders, similar to the findings of previous studies 8, [13] [14] [15] [16] . However, in the WebMD data, we could not detect signals by these disproportionality analyses due to the small number of AE cases, although psychiatric and gastrointestinal disorders were the most common AEs reported. abstract: The recommended antiviral drugs available for the treatment and prevention of influenza are neuraminidase inhibitors (NAIs). The aim of this study was to evaluate age-related clinical manifestations of adverse events (AEs) related to NAIs. FAERS and WebMD data were downloaded. The available NAIs selected for the analysis were oseltamivir, peramivir, zanamivir, and laninamivir. Disproportionality was analyzed using the proportional reporting ratio (PRR), the reporting odds ratio (ROR), and the information component (IC) methods. In total, 16729 AEs from 4598 patients and 575 AEs from 440 patients in the FAERS and WebMD, respectively, were included in the analysis. In the FAERS, AEs were more common among those who were younger (<19 years) for zanamivir, while for those who were older (>65 years) for peramivir. A disproportionality analysis showed that signals for vomiting and hallucinations were detected in younger patients given oseltamivir, while an abnormal hepatic function, cardiac failure, shock, and cardio-respiratory arrest were detected in older patients given peramivir. Psychiatric disorders were most common in younger and older patients, while gastrointestinal disorders were most common in adult given oseltamivir in the WebMD. Adverse symptoms related to NAIs varied and depended on the drugs used and the age of the patient. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033147/ doi: 10.1038/s41598-020-60068-5 id: cord-327597-fgnrujsf author: Han, Susie A. title: Clinical and Ethical Considerations in Allocation of Ventilators in an Influenza Pandemic or Other Public Health Disaster: A Comparison of the 2007 and 2015 New York State Ventilator Allocation Guidelines date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: During an influenza or coronavirus disease 2019 (COVID-19) pandemic that results in acute respiratory distress, the number of available ventilators will not meet demand. In 2007, the New York State Task Force on Life and the Law and Department of Health released draft Guidelines for ethical allocation of ventilators for adults. In 2015, updated guidelines were released to ensure that: (1) revisions reflect the public’s values and (2) the triage protocol is substantiated by evidence-based clinical data. We summarize the development and content of the 2015 Guidelines compared with the 2007 version, emphasizing new/revised aspects of the ethical considerations and clinical protocol. METHODS: We compared the 2007 and 2015 guidelines, with particular emphasis on the ethical issues and clinical protocols. RESULTS: The 2015 Guidelines retained much of the ethical and clinical framework of the 2007 draft. The triage protocol was revised using evidence-based clinical data. Patients with the highest likelihood of short-term survival with ventilator therapy have priority access. Protocol consists of exclusion criteria, the sequential organ failure assessment (SOFA) score, and periodic clinical assessments. Guidance is provided on secondary triage criteria. Other forms of medical intervention/palliative care and review of triage decisions are discussed. CONCLUSIONS: The 2015 Guidelines reflect advances in medicine and societal values and provide an evidenced-based framework to save the most lives. The framework could be adapted in other emergencies, such as the COVID-19 pandemic, that require ventilators. url: https://www.ncbi.nlm.nih.gov/pubmed/32660660/ doi: 10.1017/dmp.2020.232 id: cord-274666-0d8oz51l author: Han, Yi title: Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study date: 2020-06-24 words: 3807.0 sentences: 197.0 pages: flesch: 54.0 cache: ./cache/cord-274666-0d8oz51l.txt txt: ./txt/cord-274666-0d8oz51l.txt summary: Conclusions: This study showed that LDH could be identified as a powerful predictive factor for early recognition of lung injury and severe COVID-19 cases. To assess the risk factors of the demographics, characteristics, and laboratory indicators on the severity of COVID-19 patients, logistic regression analysis was performed on the parameters of significant difference using t test. Apart from the risk factors above, patient age, white blood cell count, neutrophil count, serum AST, ALT, LDH, Urea, CRP, and D-dimer level were all associated with the severity of COVID-19 patients. As a result, serum lymphocytes (OR:0.2, 95% CI:0.04-0.96, P < 0.05), CRP (OR:1.026, 95% CI:1.006-1.046, P < 0.05), and LDH (OR:1.009, 95% CI:1.002-1.016, P < 0.05) were found to be independent risk factors for the severity of COVID-19 patients ( Table 3) . And importantly, lymphocytes, especially CD3 + , CD4 + , and CD8 + T cells in the peripheral blood of COVID-19 patients, which was relevant with serum LDH, were also dynamically correlated with the severity of the disease. abstract: Background: The World Health Organization has declared coronavirus disease 2019 (COVID-19) a public health emergency of global concern. Updated analysis of cases might help identify the risk factors of illness severity. Results: The median age was 63 years, and 44.9% were severe cases. Severe patients had higher APACHE II (8.5 vs. 4.0) and SOFA (2 vs. 1) scores on admission. Among all univariable parameters, lymphocytes, CRP, and LDH were significantly independent risk factors of COVID-19 severity. LDH was positively related both with APACHE II and SOFA scores, as well as P/F ratio and CT scores. LDH (AUC = 0.878) also had a maximum specificity (96.9%), with the cutoff value of 344.5. In addition, LDH was positively correlated with CRP, AST, BNP and cTnI, while negatively correlated with lymphocytes and its subsets. Conclusions: This study showed that LDH could be identified as a powerful predictive factor for early recognition of lung injury and severe COVID-19 cases. Methods: We extracted data regarding 107 patients with confirmed COVID-19 from Renmin Hospital of Wuhan University. The degree of severity of COVID-19 patients (severe vs. non-severe) was defined at the time of admission according to American Thoracic Society guidelines for community acquired pneumonia. url: https://doi.org/10.18632/aging.103372 doi: 10.18632/aging.103372 id: cord-258093-6fn8ei9f author: Hanania, Nicola A. title: Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop date: 2011-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Asthma in the elderly is underdiagnosed and undertreated, and there is a paucity of knowledge on the subject. The National Institute on Aging convened this workshop to identify what is known and what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of asthma in the elderly. Asthma presenting at an advanced age often has similar clinical and physiologic consequences as seen with younger patients, but comorbid illnesses and the psychosocial effects of aging might affect the diagnosis, clinical presentation, and care of asthma in this population. At least 2 phenotypes exist among elderly patients with asthma; those with longstanding asthma have more severe airflow limitation and less complete reversibility than those with late-onset asthma. Many challenges exist in the recognition and treatment of asthma in the elderly. Furthermore, the pathophysiologic mechanisms of asthma in the elderly are likely to be different from those seen in young asthmatic patients, and these differences might influence the clinical course and outcomes of asthma in this population. url: https://www.ncbi.nlm.nih.gov/pubmed/21872730/ doi: 10.1016/j.jaci.2011.06.048 id: cord-343490-94vkfrtw author: Handaya, Adeodatus Yuda title: Covid-19 mimicking symptoms in emergency gastrointestinal surgery cases during pandemic: a case series date: 2020-10-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The COVID-19 pandemic has changed patient management in all sectors. All patients need to be examined for COVID-19, including in digestive surgery emergency cases. In this paper, we report four digestive surgery emergency cases with clinical and radiological findings similar to COVID-19. CASE PRESENTATION: We report four digestive surgery emergency cases admitted with fever and cough symptoms. Case 1 is a 75-year-old male with gastric perforation and pneumonia, case 2 is a 32-year-old female with intestinal and pulmonal tuberculosis, case 3 is a 30-year-old female with acute pancreatitis with pleuritis and pleural effusion, and the last case is a 56-year-old female with rectosigmoid cancer with pulmonal metastases. All the patients underwent emergency laparotomy, were hospitalized for therapy, and discharged from the hospital. After 1-month follow-up after surgery, 1 patient had no complaints, 2 patients had surgical site infection, and 1 patient died because of ARDS due to lung metastases. DISCUSSION: For all four cases, the surgeries were done with strict COVID-19 protocol which included patient screening, examination, laboratory assessment, rapid test screening, and RT-PCR testing. There were no intrahospital mortalities and all the patients were discharged from the hospital. Three patients were followed-up and recovered well with 2 patients having surgical site infection which recovered within a week. However, 1 patient did not show up for the scheduled follow-up and was reported dead 2 weeks after surgery because of ARDS due to lung metastases. CONCLUSIONS: Emergency surgery, especially digestive surgery cases, can be done in the COVID-19 pandemic era with strict prior screening and examination, and safety protocol. url: https://doi.org/10.1016/j.ijscr.2020.10.064 doi: 10.1016/j.ijscr.2020.10.064 id: cord-269564-r5mmsnbx author: Hans, Diana title: Rapidly Fatal Infections date: 2008-05-31 words: 7549.0 sentences: 426.0 pages: flesch: 46.0 cache: ./cache/cord-269564-r5mmsnbx.txt txt: ./txt/cord-269564-r5mmsnbx.txt summary: Reports have suggested a mortality rate of 30% to 70% despite aggressive treatment [35] TSS is most commonly caused by Staphylococcus aureus and group A streptococcus. Unfortunately, complicated group A streptococcus infections are shown to have a high mortality rate despite aggressive antibiotic therapy, and penicillin has been shown to have limited effects if not initiated early in the disease. Fifty-three percent of the patients were positive for MRSA, and the risk factors associated with colonization included recent antibiotic use (within 3 months), hospitalization within the past year, skin or soft tissue infection on admission, and HIV infection [68] . PVL-positive S aureus pneumonia typically occurred in younger patients (median age, 14.8 years) who were previously healthy, and 75% were found to have had a viral infection in the preceding days. Two deadly viral infections that have emerged in recent years include severe acute respiratory syndrome (SARS) and influenza A (H5N1), also known as avian influenza or bird flu. abstract: Emergency physicians are trained to separate “sick” from “not sick” patients during their training. Nevertheless, every emergency physician will face situations in which early intervention is critical to their patient's outcome. Infectious diseases are responsible for many of these potentially poor outcomes. This article discusses early identification and treatment for several rapidly fatal infections, including two newly identified travel-related illnesses. url: https://www.sciencedirect.com/science/article/pii/S0733862708000047 doi: 10.1016/j.emc.2008.01.003 id: cord-337487-1lbopaso author: Hansildaar, Romy title: Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout date: 2020-09-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The increased risk of cardiovascular morbidity and mortality in rheumatoid arthritis and gout has been increasingly acknowledged in past decades, with accumulating evidence that gout, just as with rheumatoid arthritis, is an independent cardiovascular risk factor. Although both diseases have a completely different pathogenesis, the underlying pathophysiological mechanisms in systemic inflammation overlap to some extent. Following the recognition that systemic inflammation has an important causative role in cardiovascular disease, anti-inflammatory therapy in both conditions and urate-lowering therapies in gout are expected to lower the cardiovascular burden of patients. Unfortunately, much of the existing data showing that urate-lowering therapy has consistent beneficial effects on cardiovascular outcomes in patients with gout are of low quality and contradictory. We will discuss the latest evidence in this respect. Cardiovascular disease risk management for patients with rheumatoid arthritis and gout is essential. Clinical guidelines and implementation of cardiovascular risk management in daily clinical practice, as well as unmet needs and areas for further investigation, will be discussed. url: https://doi.org/10.1016/s2665-9913(20)30221-6 doi: 10.1016/s2665-9913(20)30221-6 id: cord-296588-q2716lda author: Hanson, Kimberly E title: Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19 date: 2020-06-16 words: 10179.0 sentences: 681.0 pages: flesch: 47.0 cache: ./cache/cord-296588-q2716lda.txt txt: ./txt/cord-296588-q2716lda.txt summary: OBJECTIVE: The IDSA''s goal was to develop an evidence-based diagnostic guideline to assists clinicians, clinical laboratorians, patients and policymakers in decisions related to the optimal use of SARS-CoV-2 nucleic acid amplification tests. It is important to note as well, that not all specimens were collected from the same patient at the same time, the time of collection from symptom onset was not provided in all studies and various approaches for establishing SARS-CoV-2 positivity were used to define positive results (i.e., clinical evaluation, detection different gene targets versus nucleic acid sequencing). While NP swab collection is widely used and the primary specimen type for commercial direct SARS-CoV-2 test platforms, based on current available evidence, clinical practice, and availability of testing resources, the panel believes there are comparable alternative methods for sampling the nasal passages. abstract: BACKGROUND: Accurate molecular diagnostic tests are necessary for confirming a diagnosis of coronavirus disease 2019 (COVID-19). Direct detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acids in respiratory tract specimens informs patient, healthcare institution and public health level decision-making. The numbers of available SARS-CoV-2 nucleic acid detection tests are rapidly increasing, as is the COVID-19 diagnostic literature. Thus, the Infectious Diseases Society of America (IDSA) recognized a significant need for frequently updated systematic reviews of the literature to inform evidence-based best practice guidance. OBJECTIVE: The IDSA’s goal was to develop an evidence-based diagnostic guideline to assists clinicians, clinical laboratorians, patients and policymakers in decisions related to the optimal use of SARS-CoV-2 nucleic acid amplification tests. In addition, we provide a conceptual framework for understanding molecular diagnostic test performance, discuss the nuance of test result interpretation in a variety of practice settings, and highlight important unmet research needs in the COVID-19 diagnostic testing space. METHODS: IDSA convened a multidisciplinary panel of infectious diseases clinicians, clinical microbiologists, and experts in systematic literature review to identify and prioritize clinical questions and outcomes related to the use of SARS-CoV-2 molecular diagnostics. Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to assess the certainty of evidence and make testing recommendations. RESULTS: The panel agreed on 15 diagnostic recommendations. CONCLUSIONS: Universal access to accurate SARS-CoV-2 nucleic acid testing is critical for patient care, hospital infection prevention and the public response to the COVID-19 pandemic. Information on the clinical performance of available tests is rapidly emerging, but the quality of evidence of the current literature is considered low to very low. Recognizing these limitations, the IDSA panel weighed available diagnostic evidence and recommends nucleic acid testing for all symptomatic individuals suspected of having COVID-19. In addition, testing is recommended for asymptomatic individuals with known or suspected contact with a COVID-19 case. Testing asymptomatic individuals without known exposure is suggested when the results will impact isolation/quarantine/personal protective equipment (PPE) usage decisions, dictate eligibility for surgery, or inform administration of immunosuppressive therapy. Ultimately, prioritization of testing will depend on institutional-specific resources and the needs of different patient populations. url: https://www.ncbi.nlm.nih.gov/pubmed/32556191/ doi: 10.1093/cid/ciaa760 id: cord-330831-3b7vfv9b author: Hao, Fengyi title: A quantitative and qualitative study on the neuropsychiatric sequelae of acutely ill COVID-19 inpatients in isolation facilities date: 2020-10-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This study examined the neuropsychiatric sequelae of acutely ill patients with coronavirus disease 2019 (COVID-19) infection who received treatment in hospital isolation wards during the COVID-19 pandemic. Ten COVID-19 patients who received treatment in various hospitals in Chongqing, China; 10 age- and gender-matched psychiatric patients; and 10 healthy control participants residing in the same city were recruited. All participants completed a survey that collected information on demographic data, physical symptoms in the past 14 days and psychological parameters. Face-to-face interviews with COVID-19 patients were also performed using semi-structured questions. Among the COVID-19 patients, 40% had abnormal findings on the chest computed topography scan, 20% had dysosmia, 10% had dysgeusia, and 80% had repeated positivity on COVID-19 reverse-transcription polymerase chain reaction testing. COVID-19 and psychiatric patients were significantly more worried about their health than healthy controls (p = 0.019). A greater proportion of COVID-19 patients experienced impulsivity (p = 0.016) and insomnia (p = 0.039) than psychiatric patients and healthy controls. COVID-19 patients reported a higher psychological impact of the outbreak than psychiatric patients and healthy controls, with half of them having clinically significant symptoms of posttraumatic stress disorder. COVID-19 and psychiatric patients had higher levels of depression, anxiety and stress than healthy controls. Three themes emerged from the interviews with COVID-19 patients: (i) The emotions experienced by patients after COVID-19 infection (i.e., shock, fear, despair, hope, and boredom); (ii) the external factors that affected patients’ mood (i.e., discrimination, medical expenses, care by healthcare workers); and (iii) coping and self-help behavior (i.e., distraction, problem-solving and online support). The future direction in COVID-19 management involves the development of a holistic inpatient service to promote immune and psychological resilience. url: https://www.ncbi.nlm.nih.gov/pubmed/33077738/ doi: 10.1038/s41398-020-01039-2 id: cord-012934-c6pbr64i author: Hao, Weiming title: Vestibular prognosis in idiopathic sudden sensorineural hearing loss with vestibular dysfunction treated with oral or intratympanic glucocorticoids: a protocol for randomized controlled trial date: 2020-07-22 words: 5443.0 sentences: 280.0 pages: flesch: 43.0 cache: ./cache/cord-012934-c6pbr64i.txt txt: ./txt/cord-012934-c6pbr64i.txt summary: title: Vestibular prognosis in idiopathic sudden sensorineural hearing loss with vestibular dysfunction treated with oral or intratympanic glucocorticoids: a protocol for randomized controlled trial The primary outcomes will be vestibular function outcomes assessed by sensory organization test, caloric test, video head impulse test, cervical vestibular evoked myogenic potential, and ocular vestibular evoked myogenic potential; the secondary outcomes include self-reported vestibular dysfunction symptoms; dizziness-related handicap, visual analogue scale for vertigo and tinnitus; and pure tone audiometry. To evaluate the recovery of vestibular function, we set the recovery rates of the whole battery of vestibular function tests (SOT/caloric test/vHIT/VEMPs) as the primary outcome, which is the proportion of patients whose abnormal results of vestibular function tests at baseline recover to normal at 4-/8-week follow-up: in this study, we define a 10-dB PTA criterion as clinically significant difference based on a previous RCT [9] . abstract: BACKGROUND: Idiopathic sudden sensorineural hearing loss (ISSNHL) is a rapid-onset sensorineural hearing impairment with unclear etiology and unsatisfying treatment effects. Vestibular dysfunction has been considered as a poor indicator in the clinical manifestations and prognosis of ISSNHL, which occurred in approximately 28–57% cases. Glucocorticoids, administered through oral or intratympanic way, are currently regularly and standardly applied for ISSNHL to improve the hearing outcome. However, the vestibular prognosis of ISSNHL after routine treatments remains seldom explored. This study aims to compare the effectiveness of oral and intratympanic glucocorticoids in ISSNHL with vestibular dysfunction in terms of the pattern and trajectory of possible process of vestibular function recovery. METHODS/DESIGN: A randomized, outcome-assessor- and analyst-blinded, controlled, clinical trial (RCT) will be carried out. Seventy-two patients with ISSNHL complaining of vestibular dysfunction appearing as vertigo or imbalance will be recruited and randomized into either oral or intratympanic glucocorticoid therapy group with a 1:1 allocation ratio. The primary outcomes will be vestibular function outcomes assessed by sensory organization test, caloric test, video head impulse test, cervical vestibular evoked myogenic potential, and ocular vestibular evoked myogenic potential; the secondary outcomes include self-reported vestibular dysfunction symptoms; dizziness-related handicap, visual analogue scale for vertigo and tinnitus; and pure tone audiometry. Assessments of primary outcomes will be performed at baseline and at 4 and 8 weeks post-randomization, while assessments of secondary outcomes will be performed at baseline and 1, 2, 4, and 8 weeks post-randomization. DISCUSSION: Previous intervention studies of ISSNHL included only hearing outcomes, with little attention paid on the prognosis of vestibular dysfunction. This trial will be the first RCT study focusing on the progress and prognosis of vestibular dysfunction in ISSNHL. The efficacy of two commonly used therapies of glucocorticoids will be compared in both auditory and vestibular function fields, rather than in the hearing outcome alone. TRIAL REGISTRATION: ClinicalTrials.gov NCT03974867. Registered on 23 July 2019 url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477872/ doi: 10.1186/s13063-020-04579-6 id: cord-318063-bainw3d6 author: Haque, Mainul title: Health care-associated infections – an overview date: 2018-11-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Health care-associated infections (HCAIs) are infections that occur while receiving health care, developed in a hospital or other health care facility that first appear 48 hours or more after hospital admission, or within 30 days after having received health care. Multiple studies indicate that the common types of adverse events affecting hospitalized patients are adverse drug events, HCAIs, and surgical complications. The US Center for Disease Control and Prevention identifies that nearly 1.7 million hospitalized patients annually acquire HCAIs while being treated for other health issues and that more than 98,000 patients (one in 17) die due to these. Several studies suggest that simple infection-control procedures such as cleaning hands with an alcohol-based hand rub can help prevent HCAIs and save lives, reduce morbidity, and minimize health care costs. Routine educational interventions for health care professionals can help change their hand-washing practices to prevent the spread of infection. In support of this, the WHO has produced guidelines to promote hand-washing practices among member countries. url: https://www.ncbi.nlm.nih.gov/pubmed/30532565/ doi: 10.2147/idr.s177247 id: cord-288222-8fqfbys2 author: Hardy, Michaël title: Prothrombotic Disturbances of Hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Study date: 2020-10-24 words: 1198.0 sentences: 69.0 pages: flesch: 47.0 cache: ./cache/cord-288222-8fqfbys2.txt txt: ./txt/cord-288222-8fqfbys2.txt summary: The aim of this prospective study was therefore to describe the longitudinal changes in hemostasis parameters assessed daily in 21 COVID-19 patients during their intensive care unit (ICU) stay. Our main findings were that (i) daily standard measurements consistent with a prothrombotic state persisted over the first days and improved thereafter, but did not normalize in all patients; (ii) increased thrombin potential (hypercoagulability) and decreased fibrinolysis were frequent and (iii) a high inter-patient variability was observed. Patients initially were in a high inflammatory state (median CRP levels of 204 mg/dL during the first ten days after ICU admission); CRP levels progressively decreased over time thereafter. In light of these results and of the current knowledge on hemostasis disturbances of COVID-19 patients, we suggest that a close monitoring of a sensible set hemostatic parameters would be useful to assess individual thrombotic risk. abstract: nan url: https://doi.org/10.1016/j.thromres.2020.10.025 doi: 10.1016/j.thromres.2020.10.025 id: cord-277992-49mantab author: Harikrishnan, S. title: Cardiological society of India position statement on COVID-19 and heart failure date: 2020-05-13 words: 2472.0 sentences: 165.0 pages: flesch: 48.0 cache: ./cache/cord-277992-49mantab.txt txt: ./txt/cord-277992-49mantab.txt summary: The following were reported in CMR in one of the patients with myopericarditis who had ventricular systolic dysfunction : increased wall thickness with diffuse biventricular hypokinesis, especially in the apical segments, marked biventricular myocardial interstitial edema, and diffuse late gadolinium enhancement involving the entire biventricular wall 18 Cardiological Society of India recommends fibrinolytics and pharmacological therapy as treatment of choice in stable STEMI. COVID-19 patients who are diagnosed as having asymptomatic left ventricular systolic dysfunction or clinically overt heart failure should receive standard guideline directed therapy.Careful management of fluid balance, careful monitoring of electrolytes and renal function is very important.Another cardiovascular co-morbidity which can co-exist is venous thromboembolism and adequate prophylactic measures need to be undertaken 13 . Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19) EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF HEART TRANSPLANT RECIPIENTS DURING THE 2019 CORONAVIRUS OUTBREAK IN WUHAN, CHINA: A DESCRIPTIVE SURVEY REPORT abstract: The COVID 19 global pandemic has engulfed humanity with a huge impact on health systems across the world. Many patients develop myocardial injury which can lead to significant cardiovascular complications including HF. This will require aggressive management strategies which are evolving. Guideline directed drug therapy including ACEI/ARB/ARNI is to be continued in patients with pre-existing HF. Long-term cardiovascular effects of COVID-19 are yet to be ascertained. Protection of health care personnel from contracting the disease should be given high priority. url: https://www.sciencedirect.com/science/article/pii/S0019483220300869?v=s5 doi: 10.1016/j.ihj.2020.04.012 id: cord-320811-9sm7iz5x author: Harkin, Denis W. title: Ethics for surgeons during the COVID-19 pandemic, review article date: 2020-06-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The Covid-19 pandemic is a devastating global healthcare emergency with seismic impact on how modern surgical services function. Surgeons worry, that whilst healthcare-resources are directed against the pandemic, double effect may predict these benevolent public health efforts will cause unintended maleficent effects through delays to surgical treatment. Surgeons will make many challenging ethical judgements during this pandemic, here we conduct a narrative review of how medical ethics may help us make the best available choices. A narrative review of all the relevant papers known to the author was conducted. We discuss the key aspects of medical ethics, and how they have applied to surgeons during the Covid-19 pandemic. The four fundamental principles of medical ethics include: Beneficence, Nonmaleficence, Autonomy and Justice. Surgeons will face many decisions which shall challenge those ethical principles during the pandemic, and wisdom from medical ethics can guide surgeons, to do the right thing, make best available choices, and get the best available outcome for patients during the Covid-19 pandemic. The practice of surgery is distinguished by good judgement in the face of uncertainty, we must strive to do the right thing, advocate for our patients, and be honest in the face of uncertainty. Medical Ethics can guide us to make the best available choices for our patients during the Covid-19 pandemic, afterwards, we must emerge wiser having learnt lessons and rebuilding trust in surgical care. url: https://api.elsevier.com/content/article/pii/S2049080120301394 doi: 10.1016/j.amsu.2020.06.003 id: cord-032544-2yrqjw1o author: Haroon, Sabrina-Wong-Peixin title: Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial date: 2020-09-04 words: 5232.0 sentences: 276.0 pages: flesch: 41.0 cache: ./cache/cord-032544-2yrqjw1o.txt txt: ./txt/cord-032544-2yrqjw1o.txt summary: title: Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial DISCUSSION: Evidence of successful regression or retardation of vascular calcification will support the conduct of larger and longer-term trials aimed at reducing cardiovascular disease mortality and major adverse cardiovascular events in this high-risk population using a safe and inexpensive strategy TRIAL REGISTRATION: ClinicalTrials.gov NCT02870829. [27] A recent randomized trial reporting 1-year outcome of vitamin K2 supplementation in hemodialysis patients found no effect on aortic calcification despite reduction in dp-ucMGP. The proposed "Treatment to Reduce Vascular Calcification in Hemodialysis Patients Using Vitamin K" (Trevasc-HDK) study is therefore timely. Our trial is important even if the study is negative as we will have more insight into the baseline level and role of vitamin Kin Asian patients as well as provide us with the magnitude and progression of calcification in our multiethnic HD population. The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial abstract: INTRODUCTION: End stage renal failure patients on hemodialysis have significant vascular calcification This is postulated to be related to sub-clinical vitamin K deficiency, which is prevalent in hemodialysis patients. Vitamin K deficiency result in the failure of the matrix GLA protein (MGP) to undergo carboxylation. MGP is a natural local inhibitor of vascular calcification and the lack of functional carboxylated MGP may contribute to increase vascular calcification. Vitamin K supplement should therefore correct this anomaly and decrease the rate or severity of vascular calcification in this population of patients on long-term maintenance hemodialysis. Our study seeks to evaluate the prevalence and the progression of vascular calcification in a cohort of maintenance hemodialysis patients. It will also evaluate the efficacy of vitamin K supplementation in reducing the progression of vascular calcification in this group of patients. METHODS: This will be a single-center randomized, prospective and open-label interventional clinical trial of end stage renal failure patients on hemodialysis. We aim to recruit 200 patients. Eligible patients will be randomized to either the standard care arm or active treatment arm. Active treatment arm patients will receive standard care plus supplementation with oral vitamin K2 isoform 360 mcg 3 times weekly for a total duration of 18 months. Primary outcome measured will be absolute difference in coronary artery calcification score at 18-month between control and intervention arms. Secondary outcomes will be to compare absolute difference in aortic valve calcification, percentage of patients with regression of coronary artery calcification of at least 10%, absolute difference in aortic and systemic arterial stiffness, mortality from any cause and major adverse cardiovascular over the same period. DISCUSSION: Evidence of successful regression or retardation of vascular calcification will support the conduct of larger and longer-term trials aimed at reducing cardiovascular disease mortality and major adverse cardiovascular events in this high-risk population using a safe and inexpensive strategy TRIAL REGISTRATION: ClinicalTrials.gov NCT02870829. Registered on 17 August 2016 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02870829 National University Hospital's Institutional Review Board (2015/01000) url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478798/ doi: 10.1097/md.0000000000021906 id: cord-352302-are8vvhh author: Hartman, W. title: Hospitalized COVID-19 patients treated with Convalescent Plasma in a mid-size city in the midwest date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two million people in the United States. While many people recover from the virus uneventfully, a subset of patients will require hospital admission, some with intensive care needs including intubation, and mechanical ventilation. To date there is no cure and no vaccine is available. Passive immunotherapy by the transfusion of convalescent plasma donated by COVID-19 recovered patients might be an effective option to combat the virus, especially if used early in the course of disease. Here we report our experience of using convalescent plasma at a tertiary care center in a mid-size, midwestern city that did not experience an overwhelming patient surge. Methods Hospitalized COVID-19 patients categorized as having Severe or Life-Threatening disease according to the Mayo Clinic Emergency Access Protocol were screened, consented, and treated with convalescent plasma collected from local donors recovered from COVID-19 infection. Clinical data and outcomes were collected retrospectively. Results 31 patients were treated, 16 severe patients and 15 life-threatened patients. Overall mortality was 27% (4/31) but only patients with life-threatening disease died. 94% of transfused patients with severe disease avoided escalation to ICU care and mechanical ventilation. 67% of patients with life-threatening disease were able to be extubated. Most transfused patients had a rapid decrease in their respiratory support requirements on or about day 7 following convalescent plasma transfusion. Conclusion Our results demonstrate that convalescent plasma is associated with reducing ventilatory requirements in patients with both severe and life-threatening disease, but appears to be most beneficial when administered early in the course of disease when patients meet the criteria for severe illness. url: https://www.ncbi.nlm.nih.gov/pubmed/32607514/ doi: 10.1101/2020.06.19.20135830 id: cord-322867-1yxxe5d3 author: Hartman, William R title: Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two million people in the United States. While many people recover from the virus uneventfully, a subset of patients will require hospital admission, some with intensive care needs including intubation, and mechanical ventilation. To date there is no cure and no vaccine is available. Passive immunotherapy by the transfusion of convalescent plasma donated by COVID-19 recovered patients might be an effective option to combat the virus, especially if used early in the course of disease. Here we report our experience of using convalescent plasma at a tertiary care center in a mid-size, midwestern city that did not experience an overwhelming patient surge. Methods: Hospitalized COVID-19 patients categorized as having Severe or Life-Threatening disease according to the Mayo Clinic Emergency Access Protocol were screened, consented, and treated with convalescent plasma collected from local donors recovered from COVID-19 infection. Clinical data and outcomes were collected retrospectively. Results: 31 patients were treated, 16 severe patients and 15 life-threatened patients. Overall mortality was 27% (4/31) but only patients with life-threatening disease died. 94% of transfused patients with severe disease avoided escalation to ICU care and mechanical ventilation. 67% of patients with life-threatening disease were able to be extubated. Most transfused patients had a rapid decrease in their respiratory support requirements on or about day 7 following convalescent plasma transfusion. Conclusion: Our results demonstrate that convalescent plasma is associated with reducing ventilatory requirements in patients with both severe and life-threatening disease, but appears to be most beneficial when administered early in the course of disease when patients meet the criteria for severe illness. url: https://doi.org/10.21203/rs.3.rs-39447/v1 doi: 10.21203/rs.3.rs-39447/v1 id: cord-259767-x9s8qprc author: Harwayne-Gidansky, Ilana title: Recent Advances in Simulation for Pediatric Critical Care Medicine date: 2020-08-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: This review highlights the emerging fields of simulation research by tying innovation into principles of learning and process improvement. RECENT FINDINGS: Advances have been made in both educational simulation and simulation for quality improvement, allowing this versatile modality to be more broadly applied to healthcare and systems. SUMMARY: Simulation in pediatric critical care medicine continues to evolve. Although the majority of simulation is focused on learner education, emerging research has broadened to focus on patient- and system-centered outcomes, leading to improvement in the quality of care delivered in the ICU. url: https://www.ncbi.nlm.nih.gov/pubmed/32874773/ doi: 10.1007/s40124-020-00226-5 id: cord-004643-uu4uipfy author: Hasan, Mohammad Rubayet title: Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report date: 2020-03-20 words: 3015.0 sentences: 151.0 pages: flesch: 35.0 cache: ./cache/cord-004643-uu4uipfy.txt txt: ./txt/cord-004643-uu4uipfy.txt summary: Here, we present a fatal case of HLH secondary to cytomegalovirus (CMV) infection complicated by both anti-viral drug resistance and sepsis from multiple MDROs including pandrug-resistant superbug bacteria. Whole genome sequencing (WGS) of the MDR bacteria and metagenomic analysis of his blood sample revealed an unusual accumulation of a wide range of antimicrobial resistance mechanisms in a single patient, including antiviral resistance to ganciclovir, and resistance mechanisms to all currently available antibiotics. Ganciclovir resistance was confirmed by the presence of the A594V mutation in UL97 [6] What was unique in our patient compared to other reported CMV-associated HLH cases was the overwhelming infection with MDROs. On hospital admission, the patient was found to be colonized with multiple MDROs including VRE, and carbapenamase-producing Enterobacteriaceae, which may have been acquired during his previous hospital course in India. abstract: BACKGROUND: Infections with multidrug-resistant organisms (MDRO) pose a serious threat to patients with dysregulated immunity such as in hemophagocytic lymphohistiocytosis (HLH), but such infections have rarely been comprehensively characterized. Here, we present a fatal case of HLH secondary to cytomegalovirus (CMV) infection complicated by both anti-viral drug resistance and sepsis from multiple MDROs including pandrug-resistant superbug bacteria. CASE PRESENTATION: A previously healthy, six-year-old boy presented with a 45-day history of fever prior to a diagnosis of hemophagocytic lymphohistiocytosis and hemorrhagic colitis, both associated with CMV. On hospital admission, the patient was found to be colonized with multiple, multidrug-resistant (MDR) bacteria including vancomycin-resistant enterococci (VRE) and carbapenamase-producing organisms (CPO). He eventually developed respiratory, urine and bloodstream infections with highly drug-resistant, including pandrug-resistant bacteria, which could not be controlled by antibiotic treatment. Antiviral therapy also failed to contain his CMV infection and the patient succumbed to overwhelming bacterial and viral infection. Whole genome sequencing (WGS) of the MDR bacteria and metagenomic analysis of his blood sample revealed an unusual accumulation of a wide range of antimicrobial resistance mechanisms in a single patient, including antiviral resistance to ganciclovir, and resistance mechanisms to all currently available antibiotics. CONCLUSIONS: The case highlights both the risk of acquiring MDR superbugs and the severity of these infections in HLH patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083060/ doi: 10.1186/s12879-020-04966-z id: cord-292054-x0saq938 author: Hashizume, Misato title: Outlook of IL-6 signaling blockade for COVID-19 pneumonia date: 2020-10-05 words: 3798.0 sentences: 182.0 pages: flesch: 43.0 cache: ./cache/cord-292054-x0saq938.txt txt: ./txt/cord-292054-x0saq938.txt summary: Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population. Elevated tissue and serum levels of IL-6 have been implicated in the disease pathology of several inflammatory and autoimmune disorders including multiple myeloma, Crohn''s disease, rheumatoid arthritis (RA), Castleman disease, systemic juvenile idiopathic arthritis (sJIA), polyarticular juvenile idiopathic arthritis (pJIA), adult-onset Still''s disease (AOSD), ankylosing spondylitis, psoriatic arthritis, systemic lupus erythematosus, giant cell arteritis (GCA), Takayasu arteritis (TAK), systemic sclerosis, and cytokine-release syndrome (CRS), and targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic conditions such as RA, JIA, AOSD, GCA, TAK, and others such as Castleman disease or chimeric antigen receptor (CAR) T cell-induced CRS [2] . abstract: In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade will be crucial in informing the development of new treatment for COVID-19 pneumonia. Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population. url: https://www.ncbi.nlm.nih.gov/pubmed/33024459/ doi: 10.1186/s41232-020-00134-7 id: cord-335351-8hdok02n author: Hashmi, Muhammad Daniyal title: Assessing the need for transfer to the intensive care unit for Coronavirus-19 disease: Epidemiology and risk factors date: 2020-10-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Although many patients with coronavirus disease 2019 (Covid-19) require direct admission to the intensive care unit (ICU), some are sent after admission. Clinicians require an understanding of this phenomenon and various risk stratification approaches for recognizing these subjects. METHODS: We examined all Covid-19 patients sent initially to a ward who subsequently required care in the ICU. We examined the timing transfer and attempted to develop a risk score based on baseline variables to predict progressive disease. We evaluated the utility of the CURB-65 score at identifying the need for ICU transfer. RESULTS: The cohort included 245 subjects (mean age 59.0 ± 14.2 years, 61.2% male) and 20% were eventually sent to the ICU. The median time to transfer was 2.5 days. Approximately 1/3rd of patients were not moved until day 4 or later and the main reason for transfer (79.2%) was worsening respiratory failure. A baseline absolute lymphocyte count (ALC) of ≤0.8 10(3)/ml and a serum ferritin ≥1000 ng/ml were independently associated with ICU transfer. Co-morbid illnesses did not correlate with eventual ICU care. Neither a risk score based on a low ALC and/or high ferritin nor the CURB-65 score performed well at predicting need for transfer. CONCLUSION: Covid-19 patients admitted to general wards face a significant risk for deterioration necessitating ICU admission and respiratory failure can occur late in this disease. Neither baseline clinical factors nor the CURB-65 score perform well as screening tests to categorize these subjects as likely to progress to ICU care. url: https://www.sciencedirect.com/science/article/pii/S0954611120303437?v=s5 doi: 10.1016/j.rmed.2020.106203 id: cord-283141-dh8j7lyl author: Haskologlu, Sule title: Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency date: 2020-03-11 words: 2600.0 sentences: 172.0 pages: flesch: 47.0 cache: ./cache/cord-283141-dh8j7lyl.txt txt: ./txt/cord-283141-dh8j7lyl.txt summary: [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] Since the parental consanguinity rate is high (23.2%) in Turkey, DOCK8 deficiency has an important place among CIDs. Here, we retrospectively evaluated the clinical and immunologic features and treatment modalities of 20 patients with DOCK8 deficiency and follow-up results of hematopoietic stem cell transplant (HSCT) in 11 patients among them as a single-center experience. clinic, DOCK8 deficiency, follow-up, hematopoietic stem cell transplantation, immunological features Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 (DOCK8) deficiency Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency Clinical and immunological correction of DOCK8 deficiency by allogeneic hematopoietic stem cell transplantation following a reduced toxicity conditioning regimen Successful hematopoietic stem cell transplantation after myeloablative conditioning in three patients with dedicator of cytokinesis 8 deficiency (DOCK8) related Hyper IgE syndrome abstract: Biallelic mutations in the dedicator of cytokinesis 8 gene (DOCK8) cause a progressive combined immunodeficiency (CID) characterized by susceptibility to severe viral skin infections, atopic diseases, recurrent respiratory infections, and malignancy. Hematopoietic stem cell transplantation (HSCT) is only curative treatment for the disease. However, there is limited information about long‐term outcome of HSCT and its effect to protect against cancer development in DOCK8‐deficient patients. In this study, we retrospectively evaluated clinical and immunologic characteristics of 20 DOCK8‐deficient patients and outcome of 11 patients who underwent HSCT. We aimed to report the experience of our center and the result of the largest transplantation series of DOCK8 deficiency in our country. Median follow‐up time is 71 months (min‐max: 16‐172) in all patients and 48 months (min‐max: 5‐84) in transplanted patients. Atopic dermatitis (18/20), recurrent respiratory tract infections (17/20), and food allergy (14/20) were the most frequent clinical manifestations. Failure to thrive (13/20), liver problems (12/20), bronchiectasis (11/20), chronic diarrhea (10/21), and autism spectrum disorders (3/20) were remarkable findings in our series. Elevated IgE level (20/20) and eosinophilia (17/20), low IgM level (15/20), and decreased CD3+ T (10/20) and CD4+ T (11/20) cell count were prominent laboratory findings. HSCT was performed in 11 patients. All patients achieved adequate engraftment and showed improvement in their clinical and immunologic findings. Atopic dermatitis and food allergies improved in all patients, and their dietary restriction was stopped except one patient who was transplanted recently. The frequency of infections was decreased. The overall survival is 91% in HSCT‐received patients and 80% in all. HSCT at the earliest possible period with most suitable donor‐ and patient‐specific appropriate conditioning regimen and GvHD prophylaxis is lifesaving for DOCK8 deficiency cases. url: https://doi.org/10.1111/pai.13236 doi: 10.1111/pai.13236 id: cord-297127-nhgm09db author: Hasseli, Rebecca title: National registry for patients with inflammatory rheumatic diseases (IRD) infected with SARS-CoV-2 in Germany (ReCoVery): a valuable mean to gain rapid and reliable knowledge of the clinical course of SARS-CoV-2 infections in patients with IRD date: 2020-09-02 words: 4093.0 sentences: 218.0 pages: flesch: 45.0 cache: ./cache/cord-297127-nhgm09db.txt txt: ./txt/cord-297127-nhgm09db.txt summary: OBJECTIVES: Patients with inflammatory rheumatic diseases (IRD) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be at risk to develop a severe course of COVID-19. 2 In this situation, patients with inflammatory rheumatic diseases (IRD) may face a particular risk as their disease, especially when clinically active, and their immunomodulatory treatment may impact the course of COVID-19 infection. However, firm knowledge of the course of SARS-CoV-2 infection in patients with IRD is missing, and therefore, evidence-based recommendations for the management of COVID-19 in patients with rheumatic disorders and antirheumatic treatments are lacking. As necessary data cannot be extracted from clinical charts or health insurance records, the DGRh and the Justus-Liebig University Giessen decided to establish a web-based registry, which allows a rapid and timely collection of IRD cases with confirmed SARS-CoV-2 infections in Germany to analyse the clinical course of SARS-CoV-2 infections in patients with IRD and to develop guidance for the management of patients with IRD during the COVID-19 pandemic. abstract: OBJECTIVES: Patients with inflammatory rheumatic diseases (IRD) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be at risk to develop a severe course of COVID-19. The influence of immunomodulating drugs on the course of COVID-19 is unknown. To gather knowledge about SARS-CoV-2 infections in patients with IRD, we established a registry shortly after the beginning of the pandemic in Germany. METHODS: Using an online questionnaire (www.COVID19-rheuma.de), a nationwide database was launched on 30 March 2020, with appropriate ethical and data protection approval to collect data of patients with IRD infected with SARS-CoV-2. In this registry, key clinical and epidemiological parameters—for example, diagnosis of IRD, antirheumatic therapies, comorbidities and course of the infection—are documented. RESULTS: Until 25 April 2020, data from 104 patients with IRD infected with SARS-CoV-2 were reported (40 males; 63 females; 1 diverse). Most of them (45%) were diagnosed with rheumatoid arthritis, 59% had one or more comorbidities and 42% were treated with biological disease-modifying antirheumatic drugs. Hospitalisation was reported in 32% of the patients. Two-thirds of the patients already recovered. Unfortunately, 6 patients had a fatal course. CONCLUSIONS: In a short time, a national registry for SARS-CoV2-infected patients with IRD was established. Within 4 weeks, 104 cases were documented. The registry enables to generate data rapidly in this emerging situation and to gain a better understanding of the course of SARS-CoV2-infection in patients with IRD, with a distinct focus on their immunomodulatory therapies. This knowledge is valuable for timely information of physicians and patients with IRD, and shall also serve for the development of guidance for the management of patients with IRD during this pandemic. url: https://doi.org/10.1136/rmdopen-2020-001332 doi: 10.1136/rmdopen-2020-001332 id: cord-030502-mvlib8ol author: Hatachi, Takeshi title: Early steroid pulse therapy among children with influenza virus-associated encephalopathy date: 2020-08-12 words: 4265.0 sentences: 222.0 pages: flesch: 44.0 cache: ./cache/cord-030502-mvlib8ol.txt txt: ./txt/cord-030502-mvlib8ol.txt summary: CONCLUSIONS: We did not observe the effectiveness of early steroid pulse therapy on patient outcomes among children with IAE in our study population including all clinical subtypes of IAE. In this study, we aimed to assess the effectiveness of early steroid pulse therapy on patient outcomes among children with all subtypes of IAE using a nationwide database in Japan. We observed no significant difference in patient outcomes between the propensity score-matched patients with and without early steroid pulse therapy in our study population, including all clinical subtypes of IAE. In our study population including all clinical subtypes of IAE, after adjusting for the factors in Table 1 , we did not observe a significant difference in the proportions of unfavorable outcomes or in-hospital mortality between the patients with and without early steroid pulse therapy within 2 days. abstract: BACKGROUND: Influenza virus-associated encephalopathy (IAE) can lead to neurological sequela and mortality among children. Therefore, instant recognition and therapeutic intervention for IAE are crucial. In some clinical subtypes of IAE, steroid pulse therapy might be beneficial, especially when it is administered in the early phase. However, early identification of patients who may benefit from steroid pulse therapy is sometimes difficult. We aimed to assess the effectiveness of early steroid pulse therapy among children with IAE. METHODS: In this retrospective observational study, we used a national database that covers half of the acute care inpatients across Japan to identify inpatients aged ≤ 18 years with a diagnosis of IAE between July 2010 and March 2017. Unfavorable outcome was defined as a composite outcome of sequela including Japan Coma Scale ≥ 10 at discharge, requiring tracheostomy, mechanical ventilation, enteral tube feeding, rehabilitation at discharge, or in-hospital death. Propensity score matching was performed to compare unfavorable outcome and in-hospital mortality between patients with and without steroid pulse therapy within 2 days of admission. RESULTS: Among 692 patients included in the study, the mean age was 5.8 years, and 55.8% were male. The overall in-hospital mortality was 1.3%, and the proportion of the unfavorable outcome was 15.0%. We observed no significant difference in the unfavorable outcome between matched patients (168 patients in each group) with and without early steroid pulse therapy (13.7% vs 8.3%; P = 0.16) or in-hospital mortality (0.6% vs 1.2%; P = 1.0). CONCLUSIONS: We did not observe the effectiveness of early steroid pulse therapy on patient outcomes among children with IAE in our study population including all clinical subtypes of IAE. Further studies considering severity of illness are warranted to determine whether steroid pulse therapy is beneficial, especially for specific clinical subtypes of IAE. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422675/ doi: 10.1186/s40560-020-00479-8 id: cord-011138-y9v5ivzg author: Hatchimonji, Justin S. title: Questioning dogma: does a GCS of 8 require intubation? date: 2020-05-07 words: 3232.0 sentences: 179.0 pages: flesch: 52.0 cache: ./cache/cord-011138-y9v5ivzg.txt txt: ./txt/cord-011138-y9v5ivzg.txt summary: We investigated the effect of intubation in trauma patients with a GCS 6–8, with the hypothesis that intubation would increase mortality and length of stay. CONCLUSION: Among patients with GCS of 6 to 8, intubation on arrival was associated with an increase in mortality and with longer ICU and overall length of stay. Likewise, the Eastern Association for the Surgery of Trauma (EAST) practice management guidelines (PMGs) give a level 1 recommendation for intubation for patients with a GCS of 8 [2, 3] . Using IPWRA analysis adjusted for GCS, age, sex, hypotension, maximum head, chest, and abdomen/pelvis abbreviated injury scale (AIS) scores, we determined that the average treatment effect (ATE) of intubation was associated with increased odds of mortality (OR 1.05, 95% CI 1.03-1.06). Among patients with GCS of 6-8, intubation on arrival was associated with increased mortality, ICU days, and overall length of stay. abstract: BACKGROUND: There is no evidence supporting intubation for a Glasgow Coma Scale (GCS) of 8. We investigated the effect of intubation in trauma patients with a GCS 6–8, with the hypothesis that intubation would increase mortality and length of stay. METHODS: We studied adult patients with GCS 6–8 from the 2016 National Trauma Data Bank. Intubated and non-intubated patients were compared using inverse probability weighted regression adjustment (IPWRA) to control for injury severity and patient characteristics. Outcomes were mortality, intensive care unit length of stay (ICU LOS), and total LOS. Stratified analysis was performed to investigate the effect in patients with and without head injuries. RESULTS: Among 6676 patients with a GCS between 6 and 84,078 were intubated within 1 h of arrival to the emergency department. The overall mortality rate was 15.1%. IPWRA revealed an increase in mortality associated with intubation (OR 1.05, 95% CI 1.03, 1.06). The results were similar in patients with head injuries (OR 1.04, 95% CI 1.02, 1.06) and without (OR 1.06, 95% CI 1.03, 1.10). Among the 5,742 patients admitted to the ICU, intubation was associated with a 14% increase in ICU LOS (95% CI 8–20%; 5.5 vs. 4.8 days; p < 0.001). The overall length of stay was 27% longer (95% CI 19.8–34.3%) among intubated patients (mean 7.7 vs 6.0 days; p < 0.001). CONCLUSION: Among patients with GCS of 6 to 8, intubation on arrival was associated with an increase in mortality and with longer ICU and overall length of stay. The use of a strict threshold GCS to mandate intubation should be revisited. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223660/ doi: 10.1007/s00068-020-01383-4 id: cord-005717-x7gsqlwp author: Hauser, Gabriel J. title: Pediatric intestinal and multivisceral transplantation: a new challenge for the pediatric intensivist date: 2008-05-24 words: 5190.0 sentences: 260.0 pages: flesch: 29.0 cache: ./cache/cord-005717-x7gsqlwp.txt txt: ./txt/cord-005717-x7gsqlwp.txt summary: RESULTS: Preoperative management focuses on optimization of organ function, minimizing ventilator-induced lung injury, preventing excessive edema yet maintaining adequate organ perfusion, preventing and controlling sepsis and bleeding from varices at enterocutaneous interfaces, and optimizing nutritional support. Critical care immediately after intestinal transplantation (Table 2) is influenced by the overall state of health of the patient at the time of surgery, specific organs included in the composite graft, hemodynamic stability in the operating room, and immediate graft function. Patients with multivisceral transplants usually remain intubated for several days, particularly when large graft size mandates delayed abdominal closure (Table 3) , however, the priority must be early extubation to reduce the risk of ventilator-associated pneumonia. When the primary indication for transplantation is declining central vein access, patients that are managed by a competent intestinal failure team usually present with appropriate nutritional status. Pre-transplant nutritional management of patients who are in both liver and intestinal failure is more challenging [40] . abstract: INTRODUCTION: With increasing survival rates, intestinal transplantation (ITx) and multivisceral transplantation have reached the mainstream of medical care. Pediatric candidates for ITx often suffer from severe multisystem impairments that pose challenges to the medical team. These patients frequently require intensive care preoperatively and have unique intensive care needs postoperatively. METHODS: We reviewed the literature on intensive care of pediatric intestinal transplantation as well as our own experience. This review is not aimed only at pediatric intensivists from ITx centers; these patients frequently require ICU care at other institutions. RESULTS: Preoperative management focuses on optimization of organ function, minimizing ventilator-induced lung injury, preventing excessive edema yet maintaining adequate organ perfusion, preventing and controlling sepsis and bleeding from varices at enterocutaneous interfaces, and optimizing nutritional support. The goal is to extend life in stable condition to the point of transplantation. Postoperative care focuses on optimizing perfusion of the mesenteric circulation by maintaining intravascular volume, minimizing hypercoagulability, and providing adequate oxygen delivery. Careful monitoring of the stoma and its output and correction of electrolyte imbalances that may require renal replacement therapy is critical, as are monitoring for and aggressively treating infections, which often present with only subtle clinical clues. Signs of intestinal rejection may be non-specific, and early differentiation from other causes of intestinal dysfunction is important. Understanding of the expanding armamentarium of immunosuppressive agents and their side-effects is required. CONCLUSIONS: As outcomes of ITx improve, transplant teams accept patients with higher pre-operative morbidity and at higher risk for complications. Many ITx patients would benefit from earlier referral for transplant evaluation before severe liver disease, recurrent central venous catheter-related sepsis and venous thromboses develop. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095271/ doi: 10.1007/s00134-008-1141-5 id: cord-006975-u5ecibta author: Haviland, Kelly title: Outcomes after long-term mechanical ventilation of cancer patients date: 2020-03-30 words: 3608.0 sentences: 183.0 pages: flesch: 49.0 cache: ./cache/cord-006975-u5ecibta.txt txt: ./txt/cord-006975-u5ecibta.txt summary: The outcomes achieved by medical care of patients requiring mechanical ventilation have been incompletely characterized with regard to the likelihood of both weaning and survival, and even less so with regard to quality of life during the time these patients remain alive. To measure whether the creation of a dedicated weaning program altered the outcomes seen in this patient population, we performed a single-institution retrospective study of cancer patients requiring long-term mechanical ventilation who were cared for in a specialized intermediate care weaning unit. Design, setting, and eligibility criteria After a waiver of authorization (WA0023-13) was obtained from the Institutional Review Board at Memorial Sloan Kettering Cancer Center, we performed a retrospective review of a single institution''s experience with all patients treated with prolonged mechanical ventilation with weaning as a goal of care after ICU discharge, subject to intensivist discretion, between 2008 and 2012 and between January and December 2018. abstract: BACKGROUND: The probability of weaning and of long-term survival of chronically mechanically ventilated cancer patients is unknown, with incomplete information available to guide therapeutic decisions. We sought to determine the probability of weaning and overall survival of cancer patients requiring long-term mechanical ventilation in a specialized weaning unit. METHODS: A single-institution retrospective review of patients requiring mechanical ventilation outside of a critical care setting from 2008 to 2012 and from January 1 to December 31, 2018, was performed. Demographic and clinical data were recorded, including cancer specifics, comorbidities, treatments, and outcomes. Overall survival was determined using the Kaplan-Meier approach. Time to weaning was analyzed using the cumulative incidence function, with death considered a competing risk. Prognostic factors were evaluated for use in prospective evaluations of weaning protocols. RESULTS: Between 2008 and 2012, 122 patients required mechanical ventilation outside of a critical care setting with weaning as a goal of care. The cumulative incidence of weaning after discharge from the intensive care unit was 42% at 21 days, 49% at 30 days, 58% at 60 days, 61% at 90 days, and 61% at 120 days. The median survival was 0.16 years (95% CI, 0.12 to 0.33) for those not weaned and 1.05 years (95% CI, 0.60 to 1.34) for those weaned. Overall survival at 1 year and 2 years was 52 and 32% among those weaned and 16 and 9% among those not weaned. During 2018, 36 patients at our institution required mechanical ventilation outside of a critical care setting, with weaning as a goal of care. Overall, with a median follow-up of 140 days (range, 0–425 days; average, 141 days), 25% of patients requiring long-term mechanical ventilation (9 of 36) are alive. CONCLUSIONS: Cancer patients can be weaned from long-term mechanical ventilation, even after prolonged periods of support. Implementation of a resource-intensive weaning program did not improve rates of successful weaning. No clear time on mechanical ventilation could be identified beyond which weaning was unprecedented. Short-term overall survival for these patients is poor. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106688/ doi: 10.1186/s12904-020-00544-x id: cord-018225-dozmy3lb author: Hawker, Felicity H. title: The liver in critical illness date: 2008 words: 6814.0 sentences: 319.0 pages: flesch: 45.0 cache: ./cache/cord-018225-dozmy3lb.txt txt: ./txt/cord-018225-dozmy3lb.txt summary: The paper by Harrison and co-workers, again from the King''s Liver Unit, investigates the effects of n-acetylcysteine in patients with acute liver failure, and the findings of this study have resulted in widespread use of this agent in this setting. The incidence of hypoxic hepatitis was prospectively studied for 1 year in a group of high-risk patients suffering from low cardiac output in a coronary care unit. In intensive care patients, a rapid decrease in MEGX test values is associated with increased risk of developing multiple organ failure, and a poor outcome, and consequently may have a role in investigation of the role of the liver in the multiple organ failure syndrome. We studied the effect of acetylcysteine on systemic hemodynamics and oxygen transport in 12 patients with acetaminophen-induced fulminant hepatic failure, and 8 patients with acute liver failure from other causes. The increase in oxygen delivery and consumption in response to acetylcysteine may account for its beneficial effect on survival in patients with fulminant hepatic failure induced by acetaminophen. abstract: The liver is in some ways the forgotten organ in intensive care practice. Very many more laboratory and clinical studies have investigated the role, function, and support of the lung, heart, brain, and kidney in critical illness than have studied the liver. Nevertheless, in the time of the Greek scholars, there was already acknowledgement of the role of the liver in non-hepatic diseases such as systemic sepsis, and an understanding that such involvement confers a poorer prognosis – hence the inclusion of the wisdom of Hippocrates in this compilation of classic papers. In the review article by Matuschak and Rinaldo, the reasons why liver dysfunction is associated with a poorer outcome in critical illness are explored, and the concept of the liver being a ‘driving force’ in multiple organ dysfunction is developed. In addition, jaundice without significant liver dysfunction is associated with left ventricular dysfunction, at least in the dog model developed by Professor Otto Better and his colleagues in Israel. This observation is relevant to the progressive resistance to inotropic and vasopressor agents in jaundiced critically ill patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123050/ doi: 10.1007/978-1-84800-145-9_7 id: cord-002294-qa8e90qv author: Hayakawa, Sho title: Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial date: 2016-11-07 words: 4522.0 sentences: 232.0 pages: flesch: 47.0 cache: ./cache/cord-002294-qa8e90qv.txt txt: ./txt/cord-002294-qa8e90qv.txt summary: title: Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial The administration of recombinant human soluble thrombomodulin (rhTM), which has both anti-inflammatory and anticoagulant activities, improves outcomes and respiratory function in patients with acute respiratory distress syndrome. Study data were compared with historical untreated comparison group, including 13 patients with AE-IPF who were treated without rhTM before the registration. Recombinant human soluble thrombomodulin (rhTM) demonstrates anticoagulation effects superior to heparin for the treatment of disseminated intravascular coagulation (DIC) [12] and improves the outcomes and respiratory functions in patients with sepsis-induced acute respiratory distress syndrome (ARDS) [13] . The patients who met any of the following conditions were excluded: 1) those with previous history of AE-IPF; 2) who was receiving corticosteroids or immunosuppressants; 3) who was receiving anti-coagulant therapy; 4) who had intracranial hemorrhage, pulmonary hemorrhage and/or gastrointestinal hemorrhage; 5) those with previous history of hypersensitivity against thrombomodulin; 6) those with active infectious disease; and 7) who was or possibly pregnant at the time of registration. abstract: BACKGROUND: Coagulation abnormalities are involved in the pathogenesis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). The administration of recombinant human soluble thrombomodulin (rhTM), which has both anti-inflammatory and anticoagulant activities, improves outcomes and respiratory function in patients with acute respiratory distress syndrome. Therefore, we conducted a prospective clinical study to examine the effects of rhTM on respiratory function, coagulation markers, and outcomes for patients with AE-IPF. METHODS: After registration of the protocol, the patients with AE-IPF who satisfied the study inclusion criteria were treated daily with 380 U/kg of rhTM for 7 days and steroid pulse therapy. The concomitant administration of immunosuppressants and polymyxin B-immobilized fiber column treatment was prohibited. The sample size was 10 subjects. The primary study outcome was the improvement of PaO(2)/FiO(2) ratio a week after treatment initiation. Secondary outcomes were change in D-dimer level over time and 28-day survival rate in patients without intubation. Study data were compared with historical untreated comparison group, including 13 patients with AE-IPF who were treated without rhTM before the registration. RESULTS: The mean PaO(2)/FiO(2) ratio for the rhTM treatment group (n = 10) on day 8 significantly improved compared with that on day one (two-way analysis of variance, p = 0.01). The mean D-dimer level tended to decrease in the rhTM group on day 8, but the change was not significant. The 28-day survival rate was 50 % higher in the rhTM group than in the historical untreated comparison group, but the difference was not significant. A post hoc analysis showed that overall survival time was significantly longer in the treated group compared with that of the historical untreated comparison group (p = 0.04, log-rank test). CONCLUSION: rhTM plus steroid pulse therapy improves respiratory functions in patients with AE-IPF and is expected to improve overall patient survival without using other combination therapies. TRIAL REGISTRATION: The study was registered with University Hospital Medical Information Network Clinical Trial Registry (UMIN-CTR) in October 2012 (UMIN000009082). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098285/ doi: 10.1186/s40248-016-0074-z id: cord-015884-mtpbzgr9 author: Haynes, Alice title: Current Practices for Infection Prevention in the Hospital Settings date: 2013-08-06 words: 3217.0 sentences: 152.0 pages: flesch: 46.0 cache: ./cache/cord-015884-mtpbzgr9.txt txt: ./txt/cord-015884-mtpbzgr9.txt summary: The CDC, in cooperation with the Healthcare Infection Control Practices Advisory Committee (HICPAC), established Standard Precautions to address the prevention of the spread of infectious agents in healthcare settings and are the result of combining the key components from Universal Precautions and Body Substance Isolation along with the understanding that all blood and body fl uids, except sweat, are potentially infectious, and inanimate objects are potentially contaminated with infectious agents, therefore are capable of being reservoirs in the chain of transmission of infectious agents [ 11 , 12 ] . Standard Precautions group together infection prevention practices consisting of the use of Personal Protective Equipment (PPE), such as gowns, gloves, masks, goggles or face shields, and the performance of hand hygiene, washing hands with soap and water, especially when they are visibly soiled, or using an alcohol-based hand sanitizer. abstract: The principles and practices aimed at prevention and control of hospital-acquired infections are directed at various links in the chain of transmission. They include the following: (1) to contain or eliminate the reservoirs of agents and/or to curtail the persistence of agents in a specific setting, (2) to protect the host against disease caused by microorganisms, and (3) to interrupt the transmission of infection. Interventions to modify environmental reservoirs are aimed at interrupting the transmission for these inanimate environmental sources. The barriers, e.g., masks, were used to keep the smells and “contagion” away even before the germ theory of disease was conceived. The appropriate barriers now include gloves, gowns, and eye protection for blood/body fluid–borne infections and high-filtration masks for infections transmitted by droplet nuclei. The most important and effective nosocomial infection control intervention remains the routine washing of hands before, between, and after patient contact in healthcare settings. This chapter focuses on the interruption of transmission of infectious agents in the hospital setting by Standard Precautions recommended for all patients and “isolation” of patients using precautions based on known methods of transmission. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119982/ doi: 10.1007/978-81-322-1608-7_3 id: cord-273090-fdzkfo1u author: He, Susu title: Relationship between Chest CT manifestations and immune response in COVID-19 patients date: 2020-06-20 words: 2816.0 sentences: 140.0 pages: flesch: 58.0 cache: ./cache/cord-273090-fdzkfo1u.txt txt: ./txt/cord-273090-fdzkfo1u.txt summary: In critically ill patients, the decrease of absolute value of CD4 + T cells and increase of IL-6 level are significantly correlated with the volume of lung lesions. There have been many reports that most of the 2019-nCoV patients have chest CT manifestations of pneumonia, typically showing bilateral ground-glass shadows and patchy shadows, and a few can also appear as consolidation shadows and interstitial lesions, the laboratory showed that the lymphocytes count in most patients decreased [6] [7] [8] [9] , with gradually worsened the disease, the lymphocytes absolute count continued to decline [9] , and has been There are reports in the literature that the proinflammatory cytokines IL-2, IL-6, IL-8, IL-10, and TNF-α are elevated in some 2019-nCoV patients [7] [8] . The purpose of this study is to investigate changes in lymphocytes counts and cytokines levels induced by 2019-nCoV and their effects on lung lesions, to determine the severity of the disease, and to select markers that could prompt early clinical intervention. abstract: Abstract Objectives To study the and correlations of lymphocytes and cytokines between changes of lung lesion volumes in patients with COVID-19, and to predict their correlation. Methods 93 patients with COVID-19 were divided into mild and severe groups. The data of lymphocyte subgroups and cytokines were collected, the imaging characteristics were measured and correlation analysis was performed to analyze the differences. Results 60 mild and 33 severe patients were included, Lymphocyte subsets decreased in both groups. The percentages of reduction of absolute lymphocytes value in mild and severe groups were 32% and 64% respectively. The lung CT lesion volume of all patients was 241.45 ± 282.92 cm3, among which the mild group was 151.29 ± 226.04 cm3 and the severe group was 405.38 ± 304.90 cm3, respectively. In critically ill patients, the decrease of absolute value of CD4 + T cells and increase of IL-6 level are significantly correlated with the volume of lung lesions. Conclusions The absolute values of CD3+, CD4+, and CD8 + T cells are lower in patients with COVID-19, the levels of IL-6 and IL-10 are increased. The severity of lung lesions predicts poor clinical outcomes and may be a predictor of the transition from mild to severe. url: https://doi.org/10.1016/j.ijid.2020.06.059 doi: 10.1016/j.ijid.2020.06.059 id: cord-352399-2xfzpw9m author: Hearn, Jason title: Lived Experiences and Technological Literacy of Heart Failure Patients and Clinicians at a Cardiac Care Centre in Uganda date: 2020-07-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Digital health could serve as a low-cost means of enabling better self-care in patients living with heart failure (HF) in resource-limited settings such as Uganda. However, digital health interventions previously deployed in such settings have been unsuccessful due to a lack of local patient and clinician engagement in the design process. OBJECTIVE: To engage Ugandan HF patients and clinicians regarding their experiences with HF management and technology, so as to inform the future design of a digital health intervention for HF patients in Uganda. METHODS: The study employed a convergent parallel mixed-methods design. Data collection was completed at the Uganda Heart Institute in Kampala, Uganda. Data were ascertained through a patient survey and semi-structured interviews completed with HF patients, caregivers, physicians, and nurses. A conventional content analysis approach was used to qualitatively examine interview transcripts. FINDINGS: Survey data were collected from 101 HF patients (62 female/39 male, aged 54.2 ± 17.5 years). Nearly half (48%) disagreed that they knew what to do in response to changes in their HF symptoms. Almost all patients (98%) had access to a mobile device. Many patients (63%) identified as comfortable in using mobile money – a local set of services that use Unstructured Supplementary Service Data (USSD). Interviews were completed with 19 HF patients, three caregivers, seven physicians, and three nurses. Qualitative analysis revealed four clusters of themes: overdependence of patients on the clinic, inconvenience associated with attending the clinic, inconsistent patient self-care behaviours at home, and technological abilities that favoured USSD-based services. CONCLUSIONS: Ugandan HF patients possess unmet information needs that leave them ill-equipped to care for themselves. Future digital health interventions for this population should empower patients with HF-specific information and reassurance in their self-care abilities. Based on patient preferences, such systems should harness USSD technology with which most patients are already comfortable. url: https://doi.org/10.5334/aogh.2905 doi: 10.5334/aogh.2905 id: cord-021571-7kbq0v9w author: Heath, Joan A. title: Infections Acquired in the Nursery: Epidemiology and Control date: 2009-05-19 words: 21244.0 sentences: 1014.0 pages: flesch: 41.0 cache: ./cache/cord-021571-7kbq0v9w.txt txt: ./txt/cord-021571-7kbq0v9w.txt summary: The fact that a hand hygiene campaign was associated with increased hand hygiene compliance and a lower rate of CONS-positive cultures supports this ~ontention.''~ Enterococcus has been shown to account for 10% of total nosocomial infections in neonates, 6% to 15% of bloodstream infections, 0% to 5% of cases of pneumonia, 17% of urinary tract infections, and 9% of surgical site Sepsis and meningitis are common manifestations of enterococcal infection during NICU outbreak^''^,^^; however, polymicrobial bacteremia and NEC frequently accompany enterococcal sepsis.77 Identified risk factors for enterococcal sepsis, after adjustment for birth weight, include use of a nonumbilical CVC, prolonged presence of a CVC, and bowel resection?'' Because Enterococcus colonizes the gastrointestinal tract and can survive for long periods of time on inanimate surfaces, the patient''s environment may become contaminated and, along with the infant, serve as a reservoir for ongoing spread of the organism. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150280/ doi: 10.1016/b0-72-160537-0/50037-2 id: cord-261856-i1e0uj0s author: Heffner, John E title: Chronic obstructive pulmonary disease in geriatric critical care date: 2005-03-04 words: 4810.0 sentences: 247.0 pages: flesch: 35.0 cache: ./cache/cord-261856-i1e0uj0s.txt txt: ./txt/cord-261856-i1e0uj0s.txt summary: Elderly patients with moderate to severe COPD experience acute exacerbations of their airway disease, each of which presents a risk for acute respiratory failure. Criteria for grading the severity of an acute exacerbation of chronic bronchitis American College of Chest Physicians-American College of Physicians/American Society of Internal Medicine Guidelines [13] Mild exacerbation: presence of any one of the cardinal symptoms of increased dyspnea, increased sputum volume, or increased sputum purulence with the addition of an upper respiratory infection within the past 5 days, fever with no other cause, increased wheezing or cough, or a 20% rise over baseline in respiratory rate or heart rate. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation Noninvasive positive pressure ventilation in the setting of severe, acute exacerbations of chronic obstructive pulmonary disease: more effective and less expensive abstract: COPD is a progressive disorder that is punctuated in its later stages with acute exacerbations that present a risk for respiratory failure. COPD has a disproportionate impact on older patients. In the ICU, therapy is directed toward unloading fatigued respiratory muscles, treating airway infection, and prescribing bronchodilatory drugs. Most patients survive hospitalization in the ICU for an episode of respiratory failure. The severity of the underlying lung disease, however, underlies the poor outcomes of patients in terms of postdischarge survival and quality of life. url: https://api.elsevier.com/content/article/pii/S074907040300054X doi: 10.1016/s0749-0704(03)00054-x id: cord-260456-kjmab3og author: Hegde, Shruti title: Massive Pulmonary Embolism Complicating Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report date: 2020-10-28 words: 1856.0 sentences: 127.0 pages: flesch: 51.0 cache: ./cache/cord-260456-kjmab3og.txt txt: ./txt/cord-260456-kjmab3og.txt summary: title: Massive Pulmonary Embolism Complicating Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report On bedside TTE, there was evidence of right heart strain and elevated pulmonary artery systolic pressure of 45 mmHg. All data was indicative of a massive APE as the etiology for his hemodynamic collapse. Furthermore, timely diagnosis can be made to aid in appropriate management with the help of bedside TTE and ECG in cases where CTPA is not feasible secondary to the patient''s hemodynamic instability. (1) Patients with severe coronavirus disease 2019 (COVID-19) pneumonia are hypercoagulable and are at risk for acute pulmonary embolism (APE). (2) Massive acute pulmonary embolism should always be considered in the differential diagnosis for sudden and rapid hemodynamic decline in patients with COVID-19. (3) Critical care bedside echocardiography along with other clinical indicators helps in timely diagnosis and thus treatment of APE in patients with COVID-19 pneumonia, which is lifesaving. abstract: BACKGROUND: Patients with severe COVID-19 pneumonia are hypercoagulable and are at risk for acute pulmonary embolism. Timely diagnosis is imperative for their prognosis and recovery. This case describes an otherwise healthy 55-year-old man with respiratory failure requiring mechanical ventilatory support secondary to COVID-19 pneumonia. Massive acute pulmonary embolism with right heart failure complicated his course. CASE: A healthy 55-year-old man presented to our emergency department (ED) with a sore throat, cough, and myalgia. A nasopharyngeal swab was obtained, and he was discharged for home quarantine. His swab turned positive for SARS-CoV-2 infection on real-time reverse transcriptase-polymerase chain reaction assay (RT-PCR) on day 2 of his ED visit. A week later, he represented with worsening shortness of breath, requiring intubation for hypoxic respiratory failure due to COVID-19 pneumonia. Initially, he was easy to oxygenate, had no hemodynamic compromise, and was afebrile. On day 3, he became febrile and developed significant hemodynamic instability requiring maximum vasopressor support and oxygenation difficulty. His ECG revealed sinus tachycardia with S1Q3T3 pattern. On bedside TTE, there was evidence of right heart strain and elevated pulmonary artery systolic pressure of 45 mmHg. All data was indicative of a massive APE as the etiology for his hemodynamic collapse. A decision was made to forgo computed tomography pulmonary angiography (CTPA), given his clinical instability, and systemic thrombolytic therapy was administered. Within the next 12-24 hours, his hemodynamic status significantly improved. CONCLUSIONS: This case highlights the importance of considering massive APE in COVID-19 patients as a cause of the sudden and rapid hemodynamic decline. Furthermore, timely diagnosis can be made to aid in appropriate management with the help of bedside TTE and ECG in cases where CTPA is not feasible secondary to the patient's hemodynamic instability. url: https://doi.org/10.1155/2020/8875330 doi: 10.1155/2020/8875330 id: cord-279456-oouylyx9 author: Henchi, Sonia title: First COVID-19 sub-intensive respiratory unit in Europe: the Italian experience date: 2020-06-23 words: 1501.0 sentences: 101.0 pages: flesch: 47.0 cache: ./cache/cord-279456-oouylyx9.txt txt: ./txt/cord-279456-oouylyx9.txt summary: European SARS-CoV-2 pandemic epicenter was detected in Northern Italy, in a little Italian town of Lodi province, the Lodi Hospital was therefore rapidly saturated, and in particularly the departments of respiratory diseases and Intensive Care Unit had been largely involved. In this paper, we describe how the first Sub-intensive Respiratory Unit in Europe completely dedicated to COVID-19 patients was organized and managed in our hospital. SARS-CoV-2 related disease, COVID-19, presents a wide spectrum of clinical manifestations, from flu-like symptoms to severe pneumonia and acute respiratory distress syndrome (ARDS) [2] . In UTISIR were admitted patients testing positive to SARS-CoV-2 throat swab with phenotype 3,4,5, ICU patients weaned from intubation, with tracheostomy and transferred from other low-intensity care departments of the hospital, when appropriated. 4. Respiratory failure with suspected ARDS or severe pneumonia: CPAP or intubation required → hospitalization in COVID-19 ICU or COVID19 UTISIR. abstract: European SARS-CoV-2 pandemic epicenter was detected in Northern Italy, in a little Italian town of Lodi province, the Lodi Hospital was therefore rapidly saturated, and in particularly the departments of respiratory diseases and Intensive Care Unit had been largely involved. In this paper, we describe how the first Sub-intensive Respiratory Unit in Europe completely dedicated to COVID-19 patients was organized and managed in our hospital. From February 25(th) to April 30(th) 2020, 156 patients were admitted to our Respiratory Sub-intensive Unit. Among them, 100 were discharged, 28 dead and 28 transferred to ICU for intubation. url: https://doi.org/10.4081/mrm.2020.682 doi: 10.4081/mrm.2020.682 id: cord-350200-1w5u3w8i author: Hendren, Elizabeth M. title: An Interprofessional Approach in Caring for a Patient on Maintenance Hemodialysis with COVID-19 in Toronto, Canada: An Educational Case Report date: 2020-09-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: RATIONALE: Hemodialysis patients are at significant risk from COVID-19 due to their frequent interaction with the health care system and medical comorbidities. We followed up the trajectory of the first COVID-19–positive maintenance hemodialysis patient at Sunnybrook Health Sciences Centre in Toronto. We present the lessons learned and changes in practices that occurred to prevent an outbreak in our center. PRESENTING CONCERNS OF THE PATIENT: The patient, a 66-year-old woman on in-center hemodialysis, initially presented with a 2-day history of a productive cough. She subsequently developed a fever, was placed on contact and droplet isolation, and admitted to hospital. DIAGNOSES: On March 13, 2020, the patient tested positive for COVID-19. Within the next 48 hours, she developed hypoxia and acute respiratory distress syndrome as a complication of her illness requiring an extended critical care stay. This extended critical care stay resulted in critical illness–associated secondary sclerosing cholangitis. INTERVENTIONS: An interprofessional team was established, performing rapid Plan-Do-Study-Act quality improvement cycles to improve screening practices and promote the safety of patients and staff in the hemodialysis unit. OUTCOMES: We present here the lessons learned, the changes to our screening protocols, and the clinical course of our first in-center hemodialysis patient with SARS-CoV-2. TEACHING POINTS: Regular review of the infection screening processes is paramount in preventing outbreaks of COVID-19, particularly in hemodialysis units. Hospital admission should be arranged if a patient exhibits any clinical signs of hemodynamic compromise or hypoxia. Early education for health care practitioners caring for patients with COVID-19 and refresher information regarding personal protective equipment helped promote the safety of staff and prevent health care–associated outbreaks. url: https://doi.org/10.1177/2054358120957473 doi: 10.1177/2054358120957473 id: cord-344853-s2p2csrx author: Hendren, Nicholas S. title: Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome date: 2020-04-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19) is a rapidly expanding global pandemic caused by severe acute respiratory syndrome coronavirus 2, resulting in significant morbidity and mortality. A substantial minority of patients hospitalized develop an acute COVID-19 cardiovascular syndrome, which can manifest with a variety of clinical presentations but often presents as an acute cardiac injury with cardiomyopathy, ventricular arrhythmias, and hemodynamic instability in the absence of obstructive coronary artery disease. The cause of this injury is uncertain but is suspected to be related to myocarditis, microvascular injury, systemic cytokine-mediated injury, or stress-related cardiomyopathy. Although histologically unproven, severe acute respiratory syndrome coronavirus 2 has the potential to directly replicate within cardiomyocytes and pericytes, leading to viral myocarditis. Systemically elevated cytokines are also known to be cardiotoxic and have the potential to result in profound myocardial injury. Prior experience with severe acute respiratory syndrome coronavirus 1 has helped expedite the evaluation of several promising therapies, including antiviral agents, interleukin-6 inhibitors, and convalescent serum. Management of acute COVID-19 cardiovascular syndrome should involve a multidisciplinary team including intensive care specialists, infectious disease specialists, and cardiologists. Priorities for managing acute COVID-19 cardiovascular syndrome include balancing the goals of minimizing healthcare staff exposure for testing that will not change clinical management with early recognition of the syndrome at a time point at which intervention may be most effective. This article aims to review the best available data on acute COVID-19 cardiovascular syndrome epidemiology, pathogenesis, diagnosis, and treatment. From these data, we propose a surveillance, diagnostic, and management strategy that balances potential patient risks and healthcare staff exposure with improvement in meaningful clinical outcomes. url: https://www.ncbi.nlm.nih.gov/pubmed/32297796/ doi: 10.1161/circulationaha.120.047349 id: cord-017012-yl0vanuh author: Herberg, Jethro title: Infectious Diseases and the Kidney date: 2009 words: 23980.0 sentences: 1301.0 pages: flesch: 34.0 cache: ./cache/cord-017012-yl0vanuh.txt txt: ./txt/cord-017012-yl0vanuh.txt summary: Renal involvement in infectious diseases may occur by a variety of mechanisms: direct microbial invasion of the renal tissues or collecting system may take place in conditions such as staphylococcal abscess of the kidney as a result of septicemic spread of the organism or as a consequence of ascending infection; damage to the kidney may be caused by the systemic release of endotoxin or other toxins and activation of the inflammatory cascade during septicemia or by a focus of infection distant from the kidney; ischemic damage may result from inadequate perfusion induced by septic shock; the kidney may be damaged by activation of the immunologic pathways or by immune complexes resulting from the infectious process. However, in addition to this post-infection immunologically mediated disorder, in recent years there have been increasing reports of GAS causing acute renal failure as part of an invasive infection with many features of the staphylococcal toxic shock syndrome (28) . abstract: The kidney is involved in a wide range of bacterial, viral, fungal, and parasitic diseases. In most systemic infections, renal involvement is a minor component of the illness, but in some, renal failure may be the presenting feature and the major problem in management. Although individual infectious processes may have a predilection to involve the renal vasculature, glomeruli, interstitium, or collecting systems, a purely anatomic approach to the classification of infectious diseases affecting the kidney is rarely helpful because most infections may involve several different aspects of renal function. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121468/ doi: 10.1007/978-3-540-76341-3_52 id: cord-017393-kx8kmdej author: Herbers, Alexandra title: Acute Myelogenous Leukemia and Febrile Neutropenia date: 2009-08-31 words: 13295.0 sentences: 566.0 pages: flesch: 31.0 cache: ./cache/cord-017393-kx8kmdej.txt txt: ./txt/cord-017393-kx8kmdej.txt summary: Despite numerous clinical studies, since the 1970s, no single empirical antibiotic regimen has been shown to be superior for initial treatment of patients who become febrile during a neutropenic episode after therapy with chemotherapy drugs for hematological malignancies (see Table 5 -2) [4, 9, [34] [35] [36] [37] [38] [39] [40] [41] [42] [43] [44] . Similarly, bacteremias due to Staphylococcus aureus, Pseudomonas aeruginosa, and Clostridium species as well as candidemias are more frequently encountered in patients with acute leukemia who suffer from neutropenic enterocolitis or typhlitis, the most serious disturbance of the delicate balance between mucosal damage and microbial flora in the setting of prolonged exposure to antibiotics after intermediate or high-dose cytarabine chemotherapy. In addition, if a persistently neutropenic patient has no complaints and displays no clinical, radiological, or laboratory evidence of infection, cessation of antibiotic therapy or a change to oral antimicrobials should be considered after 4 days without symptoms. abstract: Aggressive chemotherapy has a deleterious effect on all components of the defense system of the human body. The resulting neutropenia as well as injury to the pulmonary and gastrointestinal mucosa allow pathogenic micro-organisms easy access to the body. The symptoms of an incipient infection are usually subtle and limited to unexplained fever due to the absence of granulocytes. This is the reason why prompt administration of antimicrobial agents while waiting for the results of the blood cultures, the so-called empirical approach, became an undisputed standard of care. Gram-negative pathogens remain the principal concern because their virulence accounts for serious morbidity and a high early mortality rate. Three basic intravenous antibiotic regimens have evolved: initial therapy with a single antipseudomonal β-lactam, the so-called monotherapy; a combination of two drugs: a β-lactam with an aminoglycoside, a second β-lactam or a quinolone; and, thirdly, a glycopeptide in addition to β-lactam monotherapy or combination. As there is no single consistently superior empirical regimen, one should consider the local antibiotic susceptibility of bacterial isolates in the selection of the initial antibiotic regimen. Not all febrile neutropenic patients carry the same risk as those with fever only generally respond rapidly, whereas those with a clinically or microbiologically documented infection show a much slower reaction and less favorable response rate. Once an empirical antibiotic therapy has been started, the patient must be monitored continuously for nonresponse, emergence of secondary infections, adverse effects, and the development of drug-resistant organisms. The averageduration of fever in serious infections in eventually successfully treated neutropenic patients is 4–5 days. Adaptations of an antibiotic regimen in a patient who is clearly not responding is relatively straightforward when a micro-organism has been isolated; the results of the cultures, supplemented by susceptibility testing, will assist in selecting the proper antibiotics. The management of febrile patients with pulmonary infiltrates is complex. Bronchoscopy and a high resolution computer-assisted tomographic scan represent the cornerstones of all diagnostic procedures, supplemented by serological tests for relevant viral pathogens and for aspergillosis. Fungi have been found to be responsible for two thirds of all superinfections that may surface during broad-spectrum antibiotic treatment of neutropenic patients. Antibiotic treatment is usually continued for a minimum of 7 days or until culture results indicate that the causative organism has been eradicated and the patient is free of major signs and symptoms. If a persistently neutropenic patient has no complaints and displays no evidence of infection, early watchful cessation of antibiotic therapy or a change to the oral regimen should be considered. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121946/ doi: 10.1007/978-1-59745-415-5_5 id: cord-293964-hz5uow2b author: Hermann, Matthias title: Feasibility and Efficacy of Cardiopulmonary Rehabilitation following COVID-19 date: 2020-07-22 words: 2728.0 sentences: 163.0 pages: flesch: 46.0 cache: ./cache/cord-293964-hz5uow2b.txt txt: ./txt/cord-293964-hz5uow2b.txt summary: Infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2), hereafter referred as COVID-19, often affects patients with chronic health conditions and takes a more severe course in patients with comorbidities such as cardiovascular disease, diabetes mellitus, and obesity. Within two days after admission for rehabilitation all patients were assessed with questionnaires, such as Chronic Respiratory Questionnaire (CRQ), Hospital Anxiety and Depression Scale (HADS), and Cumulative Illness Rating scale (CIRS) and Functional Independence Measure (FIM). To measure changes during rehabilitation, functional assessments with 6-minute walk test (6-MWT) and Feeling Thermometer (FT) were performed on admission and before discharge. Exercise capacity was measured at hospital admission and discharge using the 6-min walk test (6-MWT), performed once at the beginning and once at the end of the CR program after 20 days, according to the guidelines of the American Thoracic Society (ATS) and carried out by experienced, well-instructed examiners. abstract: The COVID-19 pandemic affects a large number of patients with a rapid progression of respiratory failure often requiring hospitalization or intensive care unit treatment in some patients. Survivors of severe COVID-19 suffer from persistent weakness and cardiorespiratory failure. Feasibility and potential benefit of cardiopulmonary rehabilitation (CR) after COVID-19 remains unclear. Therefore, we retrospectively analyzed a cohort of COVID-19 patients in a single center inpatient rehabilitation clinic and describe performance and outcome during CR. Patients were referred from acute care hospitals for rehabilitation after severe COVID-19. The cohort (n=28) was divided in ventilated or not ventilated patients for further analysis. 50% were female, mean age was 66 years and patients stayed in the acute hospital for 19.3±10.7 days before referral for CR. 17 patients (61%) needed previous ICU treatment in the acute care hospital. Risk factors, assessments and questionnaires on admission were comparable in both groups. Significant enhancements were observed in 6-minute walking test and Feeling Thermometer which were independent of previous ventilation status. In conclusion, comprehensive CR following COVID-19 is safe, feasible and effective. Improvements in physical performance and subjective health status were independent of previous ventilation. url: https://www.ncbi.nlm.nih.gov/pubmed/32732746/ doi: 10.1097/phm.0000000000001549 id: cord-285469-b61y9ezi author: Hernández-Fernández, Francisco title: Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description date: 2020-07-09 words: 7007.0 sentences: 368.0 pages: flesch: 42.0 cache: ./cache/cord-285469-b61y9ezi.txt txt: ./txt/cord-285469-b61y9ezi.txt summary: The aim of our study is to describe the clinical characteristics, laboratory findings, neuroimaging and available pathological anatomy data, as well as the presentation, therapeutic management and clinical outcomes of patients with acute CVD in a healthcare setting with a high incidence of transmission of this virus. We registered all hospitalized patients with COVID-19 reported during this period, and included all patients diagnosed with acute CVD, both ischaemic and haemorrhagic, treated consecutively by neurology, neurosurgery and the intensive care unit. Bivariates studies were designed to contrast the main variables among CVD patients, between ischaemic/haemorrhagic subtypes within the COVID-19 group, and to assess clinical prognosis. The other three haemorrhagic cases were detected on varying days of clinical evolution because having been intubated, sedated and treated for SARS-CoV-2 infection, the neurological manifestations were masked prior to tracheal extubation, when difficulty arousing these patients was observed. abstract: Since the appearance of the first case of coronavirus disease 2019 (COVID-19) a pandemic has emerged affecting millions of people worldwide. Although the main clinical manifestations are respiratory, an increase in neurological conditions, specifically acute cerebrovascular disease, has been detected. We present cerebrovascular disease case incidence in hospitalized patients with SARS-CoV-2 infection. Patients were confirmed by microbiological/serological testing, or on chest CT semiology. Available data on comorbidity, laboratory parameters, treatment administered, neuroimaging, neuropathological studies and clinical evolution during hospitalization, measured by the modified Rankin scale, were analysed. A bivariate study was also designed to identify differences between ischaemic and haemorrhagic subtypes. A statistical model of binary logistic regression and sensitivity analysis was designed to study the influence of independent variables over prognosis. In our centre, there were 1683 admissions of patients with COVID-19 over 50 days, of which 23 (1.4%) developed cerebrovascular disease. Within this group of patients, cerebral and chest CT scans were performed in all cases, and MRI in six (26.1%). Histological samples were obtained in 6/23 cases (two brain biopsies, and four arterial thrombi). Seventeen patients were classified as cerebral ischaemia (73.9%, with two arterial dissections), five as intracerebral haemorrhage (21.7%), and one leukoencephalopathy of posterior reversible encephalopathy type. Haemorrhagic patients had higher ferritin levels at the time of stroke (1554.3 versus 519.2, P = 0.004). Ischaemic strokes were unexpectedly frequent in the vertebrobasilar territory (6/17, 35.3%). In the haemorrhagic group, a characteristic radiological pattern was identified showing subarachnoid haemorrhage, parieto-occipital leukoencephalopathy, microbleeds and single or multiple focal haematomas. Brain biopsies performed showed signs of thrombotic microangiopathy and endothelial injury, with no evidence of vasculitis or necrotizing encephalitis. The functional prognosis during the hospital period was unfavourable in 73.9% (17/23 modified Rankin scale 4–6), and age was the main predictive variable (odds ratio = 1.5; 95% confidence interval 1.012–2.225; P = 0.043). Our series shows cerebrovascular disease incidence of 1.4% in patients with COVID-19 with high morbidity and mortality. We describe pathological and radiological data consistent with thrombotic microangiopathy caused by endotheliopathy with a haemorrhagic predisposition. url: https://doi.org/10.1093/brain/awaa239 doi: 10.1093/brain/awaa239 id: cord-300774-5mrkmctl author: Hernández-Mora, Miguel Górgolas title: Compassionate Use of Tocilizumab in Severe SARS-CoV2 Pneumonia date: 2020-10-25 words: 4340.0 sentences: 230.0 pages: flesch: 50.0 cache: ./cache/cord-300774-5mrkmctl.txt txt: ./txt/cord-300774-5mrkmctl.txt summary: INTRODUCTION: Tocilizumab is an interleukin 6 receptor antagonist which has been used for the treatment of severe SARS-CoV-2 pneumonia (SSP), aiming to ameliorate the cytokine release syndrome (CRS) -induced acute respiratory distress syndrome (ARDS). Patients with severe SARS-CoV-2 pneumonia (SSP) die due to poor oxygenation despite ventilatory support and different treatments including drugs with anti-viral activity, such as remdesivir, lopinavir/ritonavir, interferon beta, hydroxychloroquine; and/or anti-inflammatory drugs, such as corticosteroids, azithromycin and low molecular weight heparin amongst other [2] [3] [4] [5] . However, clinical and pathological studies of SARS-CoV-2 disease indicate that a systemic cytokine storm due to macrophage activation may be the leading cause of death in the vast majority of patients, usually occurring two to four weeks after primary infection [14] [22] [23] . abstract: INTRODUCTION: Tocilizumab is an interleukin 6 receptor antagonist which has been used for the treatment of severe SARS-CoV-2 pneumonia (SSP), aiming to ameliorate the cytokine release syndrome (CRS) -induced acute respiratory distress syndrome (ARDS). However, there are no consistent data whom might benefit most from it. METHODS: We provided tocilizumab on a compassionate-use basis to patients with SSP hospitalized (excluding intensive care and intubated cases) who required oxygen support to have a saturation >93%. Primary endpoint was intubation or death after 24 hours of its administration. Patients received at least one dose of 400 mg intravenous tocilizumab during March 8-2020, through April 20-2020. RESULTS: A total of 207 patients were studied and 186 analysed. The mean age was 65 years and 68% were male. A co-existing condition was present in 68 % of cases. Death prognostic factors were older age, higher IL-6, D-dimer and high sensitivity C reactive protein (HSCRP), lower total lymphocytes and severe disease requiring higher oxygen support. The primary endpoint (intubation or death) was significantly worst (37% vs 13%, p < 0·001) in those receiving the drug when the oxygen support was high (FiO2 > 0.5%). CONCLUSIONS: Tocilizumab is well tolerated in patients with severe SARS-CoV-2 pneumonia, but it has a limited effect on the evolution of cases with high oxygen support needs. url: https://www.sciencedirect.com/science/article/pii/S1201971220322499?v=s5 doi: 10.1016/j.ijid.2020.10.045 id: cord-326751-fn43p19j author: Herold, Christian J. title: Community-acquired and nosocomial pneumonia date: 2004-01-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Pneumonia is one of the leading causes of morbidity, hospitalization, and mortality in both industrialized and developing countries. In particular, pulmonary infections acquired in the community, and pneumonias arising in the hospital setting, represent a major medical and economic problem and thus a continuous challenge to health care. For the radiologist, it is important to understand that community-acquired pneumonia (CAP) and nosocomial pneumonia (NP) share a number of characteristics, but should, in many respects be regarded as separate entities. CAP and NP arise in different populations, host different spectra of causative pathogens, and pose different challenges to both the clinician and the radiologist. CAP is generally seen in outpatients, is most frequently caused by Streptococcus pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, and Chlamydia, and its radiologic diagnosis is relatively straightforward. NP, in contrast, develops in the hospital setting, is commonly caused by gram-negative bacteria, and may generate substantial problems for the radiologist. Overall, both for CAP and NP, imaging is an integral component of the diagnosis, important for classification and differential diagnosis, and helpful for follow-up. url: https://www.ncbi.nlm.nih.gov/pubmed/14749949/ doi: 10.1007/s00330-003-2162-7 id: cord-017569-fv88n70v author: Hewlett, Angela title: Viral Hemorrhagic Fever Preparedness date: 2017-09-10 words: 11178.0 sentences: 457.0 pages: flesch: 40.0 cache: ./cache/cord-017569-fv88n70v.txt txt: ./txt/cord-017569-fv88n70v.txt summary: Although each facility may wish to tailor the composition of the HICS team to their own particular needs, and each situation may require adjustment, key team members would typically include logisticians to plan to replenish PPE supply levels and address waste management issues, a public information officer (PIO), medical technical specialists to include infectious disease physicians and nurse leaders to manage the clinical care of the patient and staffing within the patient care unit, a laboratorian to address testing logistics and specimen transport challenges, a clinical research expert to facilitate the use of experimental therapies when necessary, a nurse concierge or other dedicated individual to support family needs, and a behavioral health expert to address staff well-being as well as the psychological and emotional needs of patients and families. The HLCC facilities in the United States that admitted patients infected with Ebola virus disease (EVD) have well developed teams of nurses who are able to provide skilled and effective patient care within their isolation units. abstract: The 2014–2016 outbreak of Ebola virus disease (EVD) in West Africa marked the 25th such occurrence but was noteworthy in its massive scope, causing more human morbidity and mortality than the previous 24 recorded outbreaks combined. As of April 2016, there were 28,652 cases resulting in at least 11,325 deaths, nearly all in the three nations of Guinea, Liberia, and Sierra Leone (Centers for Disease Control and Prevention. http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/index.html. Accessed 2 June 2016). Moreover, the 2014–2016 outbreak was the first in which patients, albeit few in number, were afforded sophisticated intensive care in the United States and in Europe. This “high-level containment care” (HLCC) was provided in specially designed purpose-built biocontainment units (BCUs). In this chapter, we explore the history and evolution of biocontainment, discuss its unique engineering and infection control modalities, and offer recommendations for the clinical and operational management of Ebola and other viral hemorrhagic fevers (VHFs). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122159/ doi: 10.1007/978-3-319-60980-5_21 id: cord-335141-ag3j8obh author: Higgins, G.C. title: FFP3 reusable respirators for COVID-19; adequate and suitable in the healthcare setting date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.bjps.2020.06.002 doi: 10.1016/j.bjps.2020.06.002 id: cord-252829-gn56tsz3 author: Higginson, Irene J. title: Associations between informal care costs, care quality, carer rewards, burden and subsequent grief: the international, access, rights and empowerment mortality follow-back study of the last 3 months of life (IARE I study) date: 2020-11-03 words: 5791.0 sentences: 311.0 pages: flesch: 57.0 cache: ./cache/cord-252829-gn56tsz3.txt txt: ./txt/cord-252829-gn56tsz3.txt summary: title: Associations between informal care costs, care quality, carer rewards, burden and subsequent grief: the international, access, rights and empowerment mortality follow-back study of the last 3 months of life (IARE I study) Data: ICrs reported hours and activities, care quality, positive aspects and burdens of caregiving, and completed the Texas Revised Inventory of Grief (TRIG). Multivariable logistic regression analysis explored the association of potential explanatory variables, including IC costs and care quality, on three outcomes: positive aspects and burdens of caregiving, and subsequent grief. Therefore, as part of the International, Access, Rights, and Empowerment (IARE I) study of palliative care in three countries, we aimed to determine and compare the informal care (IC) costs and their associations with selfreported caregiver burden, rewards and subsequent caregiver grief, taking account of care quality, as reported by ICrs. We conducted a mortality follow-back postal survey of key informants (normally relatives and informal carers) of decedents identified by palliative care services in participating hospitals. abstract: BACKGROUND: At the end of life, formal care costs are high. Informal care (IC) costs, and their effects on outcomes, are not known. This study aimed to determine the IC costs for older adults in the last 3 months of life, and their relationships with outcomes, adjusting for care quality. METHODS: Mortality follow-back postal survey. Setting: Palliative care services in England (London), Ireland (Dublin) and the USA (New York, San Francisco). Participants: Informal carers (ICrs) of decedents who had received palliative care. Data: ICrs reported hours and activities, care quality, positive aspects and burdens of caregiving, and completed the Texas Revised Inventory of Grief (TRIG). Analysis: All costs (formal, informal) were calculated by multiplying reported hours of activities by country-specific costs for that activity. IC costs used country-specific shadow prices, e.g. average hourly wages and unit costs for nursing care. Multivariable logistic regression analysis explored the association of potential explanatory variables, including IC costs and care quality, on three outcomes: positive aspects and burdens of caregiving, and subsequent grief. RESULTS: We received 767 completed surveys, 245 from London, 282 Dublin, 131 New York and 109 San Francisco. Most respondents were women (70%); average age was 60 years. On average, patients received 66–76 h per week from ICrs for ‘being on call’, 52–55 h for ICrs being with them, 19–21 h for personal care, 17–21 h for household tasks, 15–18 h for medical procedures and 7–10 h for appointments. Mean (SD) IC costs were as follows: USA $32,468 (28,578), England $36,170 (31,104) and Ireland $43,760 (36,930). IC costs accounted for 58% of total (formal plus informal) costs. Higher IC costs were associated with less grief and more positive perspectives of caregiving. Poor home care was associated with greater caregiver burden. CONCLUSIONS: Costs to informal carers are larger than those to formal care services for people in the last three months of life. If well supported ICrs can play a role in providing care, and this can be done without detriment to them, providing that they are helped. Improving community palliative care and informal carer support should be a focus for future investment. url: https://doi.org/10.1186/s12916-020-01768-7 doi: 10.1186/s12916-020-01768-7 id: cord-322799-opf1qwgl author: Hiremath, Channabasavaraj Shivalingaiah title: IACTS guidelines: practice of cardiovascular and thoracic surgery in the COVID-19 era date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patients undergoing cardiovascular and thoracic procedures are at an accentuated risk of higher morbidity and mortality, which are a consequence of the proliferative nature of the severe acute respiratory syndrome-corona virus 2 (SARS-CoV-2) on the lung vasculature, which in turn reflects as a cascading effect on the interdependent physiology of the cardiovascular and pulmonary organ systems. These are secondary to systemic inflammatory response syndrome and immunosuppressive responses to surgery and mechanical ventilation. Thus, the need to establish guidelines for the practice of cardiothoracic surgery which is safe for both the patient and the healthcare team presents as a priority, which is the mainstay of this article. url: https://doi.org/10.1007/s12055-020-01016-w doi: 10.1007/s12055-020-01016-w id: cord-257309-sazs5wgh author: Ho, Hsi-en title: Clinical Outcomes and Features of Covid-19 in Patients with Primary Immunodeficiencies in New York City date: 2020-10-08 words: 1341.0 sentences: 87.0 pages: flesch: 49.0 cache: ./cache/cord-257309-sazs5wgh.txt txt: ./txt/cord-257309-sazs5wgh.txt summary: title: Clinical Outcomes and Features of Covid-19 in Patients with Primary Immunodeficiencies in New York City Main Text: Coronavirus disease 2019 (Covid-19) remains an ongoing pandemic, and data on the clinical impact of SARS-CoV-2 infection in patients with primary immunodeficiency diseases (PIDs) are limited (1) (2) (3) . Here, we report the clinical features and outcomes of Covid-19 in patients from a large PID center in New York City during this period. Twelve out of 16 patients required hospitalization, 5 of which involved intensive care unit In all, 4/16 individuals died (CVID, n=2; hypogammaglobulinemia, n=1; IgA-IgG2 deficiency, n=1) and 12/16 individuals recovered from COVID-19. Lymphopenia in Covid-19 has been associated with disease severity in patients without PIDs (5) . This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) by the American Academy of Allergy, Asthma and Immunology (AAAAI). abstract: nan url: https://api.elsevier.com/content/article/pii/S2213219820311028 doi: 10.1016/j.jaip.2020.09.052 id: cord-340000-1e66aqih author: Ho, Ivy K. title: The Role of Social Cognition in Medical Decision Making with Asian American Patients date: 2020-09-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Asian Americans, the fastest growing racial group in the USA, face a host of major health disparities. There are several reasons for these disparities, and one possible contributor is provider perceptions of Asian Americans, which in turn can affect their medical decision making when treating Asian American patients. There is evidence for the influence of provider perceptions on medical decision making among patients of other racial minority groups; however, literature on Asian American patients is lacking. The present paper addresses this gap in the literature by using social cognitive theory to outline the mechanisms through which provider perception of Asian American patients can affect diagnostic and treatment decisions. These mechanisms include stereotypes and implicit biases, illusory correlations, and cognitive load. Recommendations for future research and policy development are provided. url: https://www.ncbi.nlm.nih.gov/pubmed/32926390/ doi: 10.1007/s40615-020-00867-8 id: cord-299835-92karhpl author: Ho, Khek Y. title: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore date: 2004-02-17 words: 3524.0 sentences: 163.0 pages: flesch: 52.0 cache: ./cache/cord-299835-92karhpl.txt txt: ./txt/cord-299835-92karhpl.txt summary: title: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore Participating HCWs completed a questionnaire and provided paired serum samples, which were analyzed by 2 different laboratories blinded to clinical data, by use of an enzyme-linked immunosorbent assay based on a protocol developed by the Centers for Disease Control and Prevention and a dot-blot immunoassay, with confirmation by a viral neutralization assay. Of the 372 HCWs participating in the present study, 8 were found to have positive antibodies to the SARS coronavirus in both samples by use of both test methods, and 6 had pneumonia and had been hospitalized for either probable or suspected SARS infection, whereas 2 had fever but did not have changes on chest radiographs. abstract: Background. Severe acute respiratory syndrome (SARS) is a newly recognized infectious disease that has recently emerged in East Asia and North America. Although the clinical features of acute infection have been well described, mildly symptomatic or asymptomatic infections have not been well characterized. Objective. To assess the spectrum of illness in health-care workers (HCWs). Methods. A prospective seroepidemiologic cohort study was conducted on 372 HCWs in a large teaching hospital in Singapore who were both exposed and not exposed to patients with SARS. Participating HCWs completed a questionnaire and provided paired serum samples, which were analyzed by 2 different laboratories blinded to clinical data, by use of an enzyme-linked immunosorbent assay based on a protocol developed by the Centers for Disease Control and Prevention and a dot-blot immunoassay, with confirmation by a viral neutralization assay. Results. A total of 21 patients with SARS were treated at our hospital. They were associated with transmission to 14 staff members, patients, and visitors in our hospital. Of the 372 HCWs participating in the present study, 8 were found to have positive antibodies to the SARS coronavirus in both samples by use of both test methods, and 6 had pneumonia and had been hospitalized for either probable or suspected SARS infection, whereas 2 had fever but did not have changes on chest radiographs. All seropositive HCWs had been exposed either directly or indirectly to patients with SARS. No asymptomatic, nonexposed staff members were found to be seropositive. There was a trend towards protection for HCWs who, while fully protected, had had contact with patients with SARS. Conclusions. Although the majority of cases of SARS are associated with pneumonia, a small number of mildly symptomatic individuals do seroconvert. HCWs who are exposed to patients with SARS can be infected with SARS, regardless of the intensity of exposure. This has implications for surveillance and infection control planning, in the event that SARS returns next winter. url: https://www.ncbi.nlm.nih.gov/pubmed/14767817/ doi: 10.1086/381558 id: cord-345296-4z7yfj5s author: Ho, Mei-Shang title: Neutralizing Antibody Response and SARS Severity date: 2005-11-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. With a linear mixed model, neutralizing antibody titer was shown to peak between week 5 and week 8 after onset and to decline thereafter, with a half-life of 6.4 weeks. Patients with a longer illness showed a lower neutralizing antibody response than patients with a shorter illness duration (p = 0.008). When early responders were compared with most patients, who seroconverted on and after week 3 of illness, the small proportion (17.4%) of early responders (antibody detectable within 2 weeks) had a higher death rate (29.6% vs. 7.8%) (Fisher exact test, p = 0.004), had a shorter survival time of <2 weeks (Fisher exact test, p = 0.013), and were more likely to be > 60 years of age (Fisher exact test, p = 0.01). Our findings have implications for understanding the pathogenesis of SARS and for SARS vaccine research and development. url: https://www.ncbi.nlm.nih.gov/pubmed/16318725/ doi: 10.3201/eid1111.040659 id: cord-289859-b1k9uyp6 author: Hodges, Kevin title: Successful management of COVID‐19 and associated coagulopathy in a patient with durable left ventricular assist device date: 2020-08-13 words: 1055.0 sentences: 63.0 pages: flesch: 38.0 cache: ./cache/cord-289859-b1k9uyp6.txt txt: ./txt/cord-289859-b1k9uyp6.txt summary: title: Successful management of COVID‐19 and associated coagulopathy in a patient with durable left ventricular assist device Patients with durable left ventricular assist devices pose special problems for management in the setting of COVID‐19 infection. We describe the successful management of a 44‐year‐old man with severe COVID‐19 infection and HeartMate 3 left ventricular assist device. Patients with durable left ventricular devices (LVADs) pose special problems for management in the setting of COVID-19 infection. [1] [2] [3] We present the case of a patient with ischemic cardiomyopathy supported by durable LVAD who developed severe COVID-19 infection with acute respiratory distress syndrome complicated by coagulopathy. Management of COVID-19 infection in the context of durable LVAD support requires careful institutional planning and a multidisciplinary approach. Successful management of COVID-19 and associated coagulopathy in a patient with durable left ventricular assist device abstract: Patients with durable left ventricular assist devices pose special problems for management in the setting of COVID‐19 infection. We describe the successful management of a 44‐year‐old man with severe COVID‐19 infection and HeartMate 3 left ventricular assist device. His course was complicated by cytokine storm and COVID‐19‐associated coagulopathy. We describe our institutional protocol for managing COVID‐19 infection in patients on mechanical circulatory support, focusing on the need for a thoughtful, multidisciplinary approach. url: https://doi.org/10.1111/jocs.14937 doi: 10.1111/jocs.14937 id: cord-282097-a1pwq4fi author: Hoertel, N. title: Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study date: 2020-10-27 words: 4403.0 sentences: 248.0 pages: flesch: 49.0 cache: ./cache/cord-282097-a1pwq4fi.txt txt: ./txt/cord-282097-a1pwq4fi.txt summary: When examining the association between the cumulative dose of dexamethasone received during the visit and the endpoint, we found that the administration of a cumulative dose between 60 mg to 150 mg among patients who required respiratory support was significantly associated with a lower risk of death in the crude, unadjusted analysis (HR, 0.28; SE, 0.58, p=0.028), the adjusted multivariable analysis (HR, 0.24; SE, 0.65, p=0.030), and in the univariate Cox regression model in the matched analytic sample (HR, 0.32; SE, 0.58, p=0.048), whereas no significant association was observed with a different dose. When examining the association between the cumulative dose of dexamethasone received during the visit and the endpoint, we found that the administration of a cumulative dose between 60 mg to 150 mg among patients who required respiratory support was significantly associated with a lower risk of death in the crude, unadjusted analysis (HR, 0.28; SE, 0.58, p=0.028), the adjusted multivariable analysis (HR, 0.24; SE, 0.65, p=0.030), and in the univariate Cox regression model in the matched analytic sample (HR, 0.32; SE, 0.58, p=0.048), whereas no significant association was observed with a different dose. abstract: Objective: To examine the association between dexamethasone use and mortality among hospitalized patients for COVID-19. Design: Multicenter observational retrospective cohort study. Setting: Greater Paris University hospitals, France. Participants: 12,217 adults hospitalized with COVID-19 between 24 January and 20 May 2020, including 171 patients (1.4%) who received dexamethasone orally or by intravenous perfusion during the visit. Data source: Assistance Publique-Hopitaux de Paris Health Data Warehouse. Main outcome measures: The primary endpoint was time to death. We compared this endpoint between patients who received dexamethasone and those who did not in time-to-event analyses adjusting for sex, age, obesity, current smoking status, any medical condition associated with increased COVID-19-related mortality, and clinical and biological severity of COVID-19 at admission, while stratifying by the need of respiratory support (i.e., oxygen or intubation). The primary analysis was a multivariable Cox model and the secondary analysis used a univariate Cox regression in a matched analytic sample. Results: Among patients who required respiratory support, the end-point event of death occurred in 10 patients (15.9%) who received dexamethasone and 298 patients (26.4%) who did not. In this group of patients, there was a significant association between dexamethasone use and reduced mortality in both the crude, unadjusted analysis (hazard ratio (HR), 0.40; 95% CI, 0.18 to 0.87, p=0.021) and the adjusted multivariable analysis (HR, 0.46; 95% CI, 0.22 to 0.96, p=0.039). In the sensitivity analysis, the univariate Cox regression model in the matched analytic sample yielded a same tendency, albeit non-significant (HR, 0.31; 95% CI, 0.08 to 1.14, p=0.077). Among patients without respiratory support, the end-point event of death occurred in 14 patients (13.0%) who received dexamethasone and 1,086 patients (10.0%) who did not. In this group of patients, there was no significant association between dexamethasone use and the endpoint. When examining the association between the cumulative dose of dexamethasone received during the visit and the endpoint, we found that the administration of a cumulative dose between 60 mg to 150 mg among patients who required respiratory support was significantly associated with a lower risk of death in the crude, unadjusted analysis (HR, 0.28; SE, 0.58, p=0.028), the adjusted multivariable analysis (HR, 0.24; SE, 0.65, p=0.030), and in the univariate Cox regression model in the matched analytic sample (HR, 0.32; SE, 0.58, p=0.048), whereas no significant association was observed with a different dose. Among patients without respiratory support, there was no significant association between the cumulative dose of dexamethasone and the endpoint in the crude and in the adjusted multivariable analyses. Conclusions: In this observational study involving patients with Covid-19 who had been admitted to the hospital, dexamethasone use administered either orally or by intravenous injection at a cumulative dose between 60 mg and 150 mg was associated with decreased mortality among those requiring respiratory support. url: http://medrxiv.org/cgi/content/short/2020.10.23.20218172v1?rss=1 doi: 10.1101/2020.10.23.20218172 id: cord-261801-va2e029z author: Hoffman, Pamela E. title: Rapidly scaling video visits during COVID-19: The ethos of virtual care at Yale Medicine date: 2020-10-01 words: 1372.0 sentences: 99.0 pages: flesch: 48.0 cache: ./cache/cord-261801-va2e029z.txt txt: ./txt/cord-261801-va2e029z.txt summary: Lesson 2: While resistance to change was the norm, the COVID-19 crisis motivated improvements to four major internal operational workflows (scheduling, appointment conversions, patient support and Virtual Rooming Assistants) for video visits, which were met with acceptance by both clinical and non-clinical staff. Lesson 4: Regular electronic health record (EHR) training and educational material increased end-user knowledge of video visits and helped ensure the visit was safe, medically effective and maintained patient-provider relationships. Lesson 5: A clearly defined intake and evaluation process to filter out technologies that do not integrate with the patient portal or the EHR, ensures operational consistency and long-term sustainability. • Lesson 2: While resistance to change was the norm, the COVID-19 crisis motivated 23 improvements to four major internal operational workflows (scheduling, appointment 24 conversions, patient support and Virtual Rooming Assistants) for video visits, which 25 abstract: Lesson 1: The loosening of federal government regulations enabled the rapid scaling of telehealth, as it enabled providers to be reimbursed for video visits at the same rate as in-person services. Lesson 2: While resistance to change was the norm, the COVID-19 crisis motivated improvements to four major internal operational workflows (scheduling, appointment conversions, patient support and Virtual Rooming Assistants) for video visits, which were met with acceptance by both clinical and non-clinical staff. Lesson 3: Leveraging prior intraorganizational relationships and active collaboration between different stakeholders, helped drive rapid operational change. An ongoing centralized communication and support strategy, ensured all stakeholders were informed and engaged during these uncertain times. Lesson 4: Regular electronic health record (EHR) training and educational material increased end-user knowledge of video visits and helped ensure the visit was safe, medically effective and maintained patient-provider relationships. Lesson 5: A clearly defined intake and evaluation process to filter out technologies that do not integrate with the patient portal or the EHR, ensures operational consistency and long-term sustainability. Lesson 6: Personalized support to patients of different levels of technical literacy with using the preferred patient portal and application, was vital to its use, adoption and overall patient experience. url: https://www.sciencedirect.com/science/article/pii/S2213076420300816?v=s5 doi: 10.1016/j.hjdsi.2020.100482 id: cord-302244-uwicyuhk author: Hoilat, Gilles J title: Percutaneous Mechanical Pulmonary Thrombectomy in a Patient With Pulmonary Embolism as a First Presentation of COVID-19 date: 2020-08-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There has been a high incidence of thromboembolic diseases in patients with coronavirus disease 2019 (COVID-19) pneumonia. We present a case of a healthy 32-year-old male with no past medical history who presented with shortness of breath, tested positive for COVID-19, and was found to have a large acute saddle pulmonary embolism. url: https://doi.org/10.7759/cureus.9506 doi: 10.7759/cureus.9506 id: cord-004314-gtwtakpr author: Holmen, Heidi title: Working with patients suffering from chronic diseases can be a balancing act for health care professionals - a meta-synthesis of qualitative studies date: 2020-02-10 words: 8169.0 sentences: 387.0 pages: flesch: 45.0 cache: ./cache/cord-004314-gtwtakpr.txt txt: ./txt/cord-004314-gtwtakpr.txt summary: METHOD: A systematic search of papers published between 2002 and July 2019 was conducted in the Embase, AMED, PsycINFO, MEDLINE, CINAHL, and COCHRANE databases to identify studies reporting qualitative interviews addressing HCPs'' experiences working with adults with COPD, CKD or type 2 diabetes. A research group comprising 10 senior researchers (the authors), with a professional background in either nursing or physiotherapy and qualified in realist and interpretive qualitative research methods, conducted a systematic literature review of qualitative papers concerning HCPs'' experiences working with patients with type 2 diabetes, CKD, and COPD. Based on our analysis of the results chapters of the included studies, three main themes were identified and developed, each addressing our overall aim to describe HCPs'' experiences working with patients with long-term chronic diseases: individualizing the professional approach within the clinical encounter; managing one''s emotions over time; and working to maintain professionalism (Table 4 ). abstract: BACKGROUND: The number of patients with long-term chronic diseases is increasing. These patients place a strain on health care systems and health care professionals (HCPs). Presently, we aimed to systematically review the literature on HCPs’ experiences working with patients with long-term chronic diseases such as type 2 diabetes, chronic obstructive pulmonary disease (COPD), and chronic kidney disease (CKD). METHOD: A systematic search of papers published between 2002 and July 2019 was conducted in the Embase, AMED, PsycINFO, MEDLINE, CINAHL, and COCHRANE databases to identify studies reporting qualitative interviews addressing HCPs’ experiences working with adults with COPD, CKD or type 2 diabetes. An interdisciplinary research group were involved in all phases of the study. With the help of NVivo, extracts of each paper were coded, and codes were compared across papers and refined using translational analysis. Further codes were clustered in categories that in turn formed overarching themes. RESULTS: Our comprehensive search identified 4170 citations. Of these, 20 papers met our inclusion criteria. Regarding HCPs’ experiences working with patients with COPD, CKD, or type 2 diabetes, we developed 10 sub-categories that formed three overarching main themes of work experiences: 1) individualizing one’s professional approach within the clinical encounter; 2) managing one’s emotions over time; 3) working to maintain professionalism. Overall these three themes suggest that HCPs’ work is a complex balancing act depending on the interaction between patient and professional, reality and professional ideals, and contextual support and managing one’s own emotions. CONCLUSION: Few qualitative studies highlighted HCPs’ general working experiences, as they mainly focused on the patients’ experiences or HCPs’ experiences of using particular clinical procedures. This study brings new insights about the complexity embedded in HCPs’ work in terms of weighing different, often contrasting aspects, in order to deliver appropriate practice. Acknowledging, discussing and supporting this complexity can empower HCPs to avoid burning out. Leaders, health organizations, and educational institutions have a particular responsibility to provide HCPs with thorough professional knowledge and systematic support. TRIAL REGISTRATION: PROSPERO number: CRD42019119052. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011477/ doi: 10.1186/s12913-019-4826-2 id: cord-344431-2wq7msqz author: Holzinger, Felix title: Self-referred walk-in patients in the emergency department – who and why? Consultation determinants in a multicenter study of respiratory patients in Berlin, Germany date: 2020-09-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Emergency department (ED) consultations are on the rise, and frequently consultations by non-urgent patients have been held accountable. Self-referred walk-in (SRW) consulters supposedly represent a predominantly less urgent patient population. The EMACROSS study aimed to explore consultation determinants and motives in SRW patients with respiratory symptoms. METHODS: Multicenter survey of adult ED patients with respiratory complaints in eight emergency departments in central Berlin, Germany. Secondary hospital records data including diagnoses was additionally assessed. Characteristics of SRW and non-SRW patients were compared. Determinants of SRW consultation were evaluated by binary logistic regression. Consultation motives were analyzed descriptively. As a supplemental approach, network analysis (lasso-regularized mixed graphical model) was performed to explore connections between consultation determinants, consultation features and motives. RESULTS: Between June 2017 and November 2018, n = 472 participants were included, the median age was 55 years (range 18–96), 53.2% of patients were male and n = 185 cases (39.2%) were SRW consulters. The SRW group showed lower proportions of potentially severe (pneumonia and respiratory failure, p < 0.001, χ(2) test) and chronic pulmonary conditions. Determinants of SRW consultation identified by logistic regression were younger age (p < 0.001), tertiary education (p = 0.032), being a first-generation migrant (p = 0.002) or tourist (p = 0.008), having no regular primary care provider (p = 0.036) and no chronic pulmonary illness (p = 0.017). The area under the curve (AUC) for the model was 0.79. Personal distress and access problems in ambulatory care were stated most frequently as consultation motives in the SRW group; network analysis showed the scarcity of associations between demographic and medical SRW determinants and motives triggering the actual decision to consult. CONCLUSIONS: As to “who” consults, this study identified demographic and medical predictors of SRW utilization. The said markers seem only remotely connected to “why” people decide for SRW visits. To alleviate ED crowding by addressing frequent SRW consultation motives, interventions focused on the ability for symptom self-assessment and at better-accessible alternative care seem sensible. TRIAL REGISTRATION: German Clinical Trials Register (DRKS00011930); date: 2017/04/25. url: https://www.ncbi.nlm.nih.gov/pubmed/32912185/ doi: 10.1186/s12913-020-05689-2 id: cord-307758-a4sgt66g author: Hong, Ching-Ye title: Acute respiratory symptoms in adults in general practice date: 2004-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. Community studies have shown that ∼30% of patients with acute respiratory tract symptoms have no identifiable infective aetiology. This may not be applicable in general practice. Objective. The purpose of this study was to determine the infective aetiology in patients who presented to primary care doctors with acute respiratory symptoms. Methods. A prospective study was carried out in all nine primary care clinics belonging to the National Healthcare Group Polyclinics (NHGPs) in Singapore. The subjects comprised 594 consecutive patients (318 males, 276 females) aged ≥21 years who presented with complaints of any one of cough, nasal or throat symptoms of <7 days duration. Data collection was through interview using structured questionnaire, physical examination, throat swabs for bacterial culture and nasal swabs for virus identification by immunofluorescence (IF) and polymerase chain reaction (PCR). Additional PCR was performed on a subsample of 100 patients. Patients were followed-up until resolution of symptoms. Results. The aetiological diagnosis by infective agent is as follows: 150 patients (25.2%) had virus infections, of which 90.7% (136/150) were by rhinovirus. Fourteen patients (2.4%) had bacterial infections, of which 10 were due to group G streptococcus. Group A streptococcus was not detected. Nineteen patients with new pathogens were identified by further PCR. These included parainfluenza 4, human coronavirus OC43, adenovirus, enterovirus and Chlamydia pneumoniae. No pathogen could be identified in 49% of patients. There were no differences in clinical presentation and socio-demographic variables between patients who had viral infections and those in whom no pathogen could be identified. Conclusion. In about half of patients who presented at NHGPs, no pathogens could be identified even after PCR. A non-infective aetiology could be considered in these patients. url: https://www.ncbi.nlm.nih.gov/pubmed/15128697/ doi: 10.1093/fampra/cmh319 id: cord-339021-mhdaov1f author: Hong, Kyung Soo title: Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study date: 2020-05-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Although some information on the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a few selected cases has been reported, data on the clinical characteristics and outcomes of patients hospitalized therewith in South Korea are lacking. We conducted a retrospective single-center study of 98 consecutive hospitalized patients with confirmed SARS-CoV-2 infection at Yeungnam University Medical Center in Daegu, South Korea. Sixty patients were women (61.2%), and the mean age was 55.4±17.1 years. Thirteen patients (13.3%) were treated in the intensive care unit (ICU). The mean interval from symptom onset to hospitalization was 7.7±4.5 days. Patients who received ICU care were significantly older and were more likely to have diabetes mellitus. The National Early Warning Score on the day of admission was significantly higher in patients requiring ICU care. Acute respiratory distress syndrome (13/13 patients; 100%), septic shock (9/13; 69.2%), acute cardiac injury (9/13; 69.2%), and acute kidney injury (8/13; 61.5%) were more common in patients who received ICU care. All patients received antibiotic therapy, and most (97/98 patients; 99.0%) received antiviral therapy (lopinavir/ritonavir). Hydroxychloroquine was used in 79 patients (80.6%), and glucocorticoid therapy was used in 18 patients (18.4%). In complete blood counts, lymphopenia was the most common finding (40/98 patients; 40.8%). Levels of all proinflammatory cytokines were significantly higher in ICU patients. As of March 29, 2020, the mortality rate was 5.1%. Here, we report the clinical characteristics and laboratory findings of SARS-CoV-2 patients in South Korea up to March 29, 2020. url: https://doi.org/10.3349/ymj.2020.61.5.431 doi: 10.3349/ymj.2020.61.5.431 id: cord-280129-a97rvtzl author: Honore, Patrick M. title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation date: 2020-06-16 words: 553.0 sentences: 39.0 pages: flesch: 49.0 cache: ./cache/cord-280129-a97rvtzl.txt txt: ./txt/cord-280129-a97rvtzl.txt summary: authors: Honore, Patrick M.; Barreto Gutierrez, Leonel; Kugener, Luc; Redant, Sebastien; Attou, Rachid; Gallerani, Andrea; De Bels, David title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation Patrick M. Both patients were treated with classical medical therapy including lactulose, but, despite increasing doses of lactulose for 3 days, ammonia levels remained unchanged. Retrospectively, we hypothesize that the pre-admission diarrhea may have resulted in secondary carnitine deficiency, as described in the literature [3] , leading to hyperammonemia unresponsive to medical therapy [4] . As we did not measure serum carnitine levels and we did not supply the patients with carnitine supplementation, the diagnosis of carnitine deficiency in these cases remains only a hypothesis. Liver injury in critically ill patients with COVID-19: a case series abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32546201/ doi: 10.1186/s13054-020-03088-x id: cord-330597-nftwj0d5 author: Hopfer, Helmut title: Hunting coronavirus by transmission electron microscopy – a guide to SARS‐CoV‐2‐associated ultrastructural pathology in COVID‐19 tissues date: 2020-09-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Transmission electron microscopy has become a valuable tool to investigate tissues of COVID‐19 patients because it allows visualisation of SARS‐CoV‐2, but the “virus‐like particles” described in several organs have been highly contested. Because most electron microscopists in pathology are not accustomed to analysing viral particles and subcellular structures, our review aims to discuss the ultrastructural changes associated with SARS‐CoV‐2 infection and COVID‐19 with respect to pathology, virology, and electron microscopy. Using micrographs from infected cell cultures and autopsy tissues, we show how coronavirus replication affects ultrastructure and put the morphological findings in the context of viral replication, which induces extensive remodelling of the intracellular membrane systems. Virions assemble by budding into the endoplasmic reticulum‐Golgi intermediate complex and are characterized by electron dense dots of cross‐sections of the nucleocapsid inside the viral particles. Physiological mimickers such as multivesicular bodies or coated vesicles serve as perfect decoys. Compared to other in‐situ techniques, transmission electron microscopy is the only method to visualize assembled virions in tissues and will be required to prove SARS‐CoV‐2 replication outside the respiratory tract. In practice, documenting in tissues the characteristic features seen in infected cell cultures, seems to be much more difficult than anticipated. In our view, the hunt for coronavirus by transmission electron microscopy is still on. url: https://doi.org/10.1111/his.14264 doi: 10.1111/his.14264 id: cord-340430-x4oitcyh author: Horgan, T. J. title: Oral and Maxillofacial Surgery Patient Satisfaction with Telephone Consultations during the COVID-19 pandemic date: 2020-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Introduction Due to the COVID-19 pandemic most Oral and Maxillofacial Surgery (OMFS) units have moved to conducting patient consultations over the telephone. The aim of this study was to assess patient satisfaction with telephone consultations during the COVID-19 pandemic. Methods A retrospective survey was conducted of OMFS patients at our hospital who had telephone consultations between 1st April-8th June 2020. The survey was conducted by independent interviewers and used the Generic Medical Interview Satisfaction Scale (G-MISS) along with a previously published additional questionnaire. Variables recorded included age, gender, theme of consultation, grade of clinician and type of consultation. Statistical analysis was performed to assess for any difference between patient groups. Results The records of 150 consecutive patients were reviewed and 135 met inclusion criteria. A total of 109 patients completed the survey giving a response rate of 80.74%. The total G-MISS score for satisfaction was high indicating a high level of satisfaction among all patients. We found no statistical difference in satisfaction when comparing patients in terms of gender, age, theme of consultation or level of clinician. A significant difference was found in compliance levels between review and new patients with review patients demonstrating higher compliance levels (p = 0.004). Overall, 83.48% of patients said they would be willing to have a telephone consultation in future. Conclusion The majority of patients in this study reported high levels of satisfaction with telephone consultations. New patients reported lower levels of compliance which may suggest these consultations are less amenable to telephone consultation. url: https://www.sciencedirect.com/science/article/pii/S0266435620304915?v=s5 doi: 10.1016/j.bjoms.2020.08.099 id: cord-029884-zl0uqmfi author: Horowitz, Robert K. title: MVP (Medical situation, Values and Plan): A memorable and useful model for all Serious Illness Conversations date: 2020-07-30 words: 3481.0 sentences: 260.0 pages: flesch: 61.0 cache: ./cache/cord-029884-zl0uqmfi.txt txt: ./txt/cord-029884-zl0uqmfi.txt summary: This step explores the patient''s beliefs, goals, ideology, narrative, hopes, fears, and communication, informational and decision-making preferences in the context of the now-understood medical situation. An effective SIC requires the clinician to honor patient and family autonomy and personhood by: ensuring their assent to answer questions and receive information; tailoring that information to their needs, abilities, and preferences, as well as the situational urgency; valuing and learning their history and experience; informing them to the extent possible, reasonable and desired; and ensuring their centrality to the shared decision-making process. â�¢I admire your courage in discussing this hard stuff.â�¢Now that I understand your values, I''d like to offer a recommendation, okay?â�¢If your breathing deteriorates I suggest weâ�¦ (ex.,take resuscitation off the table, and treat your symptoms at homeâ�¦ORâ�¦offer a time-limited ventilator trialâ�¦ORâ�¦)â�¢Does this make sense? abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390732/ doi: 10.1016/j.jpainsymman.2020.07.022 id: cord-318333-rzhrgp5q author: Hou, Jiabao title: COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: This study aimed to describe the epidemiologic and clinical characteristics of coronavirus disease 2019 (COVID-19) in surgical patients and medical staff. METHODS: A single-center case series of 1586 consecutive surgical patients was selected at our hospital from January 13 to March 12, 2020. The epidemiological and clinical characteristics of COVID-19 were analyzed and followed up to May 20, 2020. The transmission of COVID-19 between the surgical patients and medical staff was also recorded. RESULTS: Seventeen (1.07%) surgical patients were diagnosed with COVID-19, with a high incidence in the thoracic department (9.37%), and the median age was 58 years (IQR, 53-73). The median time from hospital admission to COVID-19 diagnosis was 9.0 days (7.0-12.0) and was 6.0 days (4.0-7.0) from the day of surgery to COVID-19 diagnosis. Eleven (64.70%) patients suffered from pulmonary infection before surgery. When COVID-19 was diagnosed, common symptoms were fever (82.35%) and cough (94.12%), and most (82.35%) neutrophil/lymphocyte ratios were high (>3.5). Chest computed tomography (CT) (82.35%) showed bilateral dense shadows. Surgical patients with COVID-19 stayed in the hospital for approximately 35.0 days (25.5-43.0), with a mortality rate of 11.76%. Sixteen medical staff were infected with COVID-19 in the early stage. CONCLUSIONS: In this series of 1586 surgical patients, the COVID-19 infection rate was 1.07%, with an especially high incidence among patients with thoracic diseases. Middle-aged and elderly patients with preoperative pulmonary infection were more susceptible to COVID-19 infection after surgery. Medical staff were infected with COVID-19 and should take protective measures to protect themselves. url: https://www.sciencedirect.com/science/article/pii/S1743919120306415?v=s5 doi: 10.1016/j.ijsu.2020.08.037 id: cord-011512-gw2sk90q author: Houlston, E. title: A simple pleasure date: 2020-05-22 words: 1933.0 sentences: 84.0 pages: flesch: 54.0 cache: ./cache/cord-011512-gw2sk90q.txt txt: ./txt/cord-011512-gw2sk90q.txt summary: Sir, the British Orthodontic Society (BOS) and the Oral Health Foundation have recently collaboratively launched a muchawaited campaign, Safe Brace Campaign, alerting the public to the dangers of direct to consumer orthodontics, also known as ''DIY Braces'' (www.safebrace.org). Sir, to determine the use and perceived benefit of webinars and online learning, a brief survey was sent to dentists across the UK; 50 responses were received from a mix of those working in general dental practice, hospital and community. 2 The calming and stress reducing effects of listening to music have been widely studied and this simple and cost-effective method of relaxation is something easily accessible to all members of the dental team. Sir, as a DCT3 in Oral Surgery I have seen several patients referred for removal of teeth under general anaesthetic (GA) due to dental anxiety. Experience of listening to music on patient anxiety during minor oral surgery procedures: a pilot study abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243228/ doi: 10.1038/s41415-020-1683-7 id: cord-322590-twnlaq24 author: Hoyer, Carolin title: Changes in Demographic and Diagnostic Spectra of Patients with Neurological Symptoms Presenting to an Emergency Department During the COVID-19 Pandemic: A Retrospective Cohort Study date: 2020-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To analyse the characteristics of patients with neurological complaints seeking evaluation in an interdisciplinary emergency department (ED) during the rise of the COVID-19 pandemic in Germany. METHODS: In this retrospective study, data on the number of ED presentations due to neurological complaints in weeks 1–15/2020 were collected. In addition, hospital chart data of patients referred for neurological evaluation during weeks 12–15/2020 when the pandemic began impacting on public life in Germany were analysed regarding demographic information, chief complaints, modes of presentation and disposition and ED discharge diagnosis. Both data sets were compared to respective periods from 2017. RESULTS: During the surge of COVID-19, we found a significant decrease of the total number of neurological ED patients by 47.6%. Comparing weeks 12–15 of 2017 and 2020, we found a decrease in the number of patients of <30 years (p<0.001) and an increase of those [Image: see text] 70 years (p<0.001). A higher proportion of patients were admitted to escalated care (p=0.03), and fewer patients were discharged against medical advice (p<0.001). In addition, the ratio of less acute diagnoses (eg, benign headaches) declined significantly. CONCLUSION: Our findings suggest that the pandemic has contributed to a – potentially transient – reframing of laypeople’s perception of urgency and necessity for emergency presentation. The establishment and promotion of health-care structures and services like telemedical consultations and the creation of safe ED environments will be essential to enable adequate delivery of care in potential future waves of the pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/33061392/ doi: 10.2147/ndt.s273913 id: cord-340651-g3518bq2 author: Hsu, Chung-Hua title: An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study date: 2007-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Natural herbal medicine (NHM) has been used to control infectious diseases for thousands of years. In view of the possible beneficial effect of NHM on SARS, we conducted this study to examine whether NHM is of any benefit as a supplementary treatment of SARS or SARS-like infectious disease. This was a randomized, double-blind, placebo-controlled trial. Twenty-eight patients fulfilled the WHO inclusion criteria and our exclusion criteria. All enrolled patients received routine western-medicine treatment. Patients were randomly allocated to one of the three supplementary treatment groups: NHM A (Group A, n = 9) NHM B (Group B, n = 9) or placebo (Group C, n = 10). Chest X-ray was done every 1 or 2 days for every patient. Reading radiologists use a standard 0–3 scoring system (0: no infiltration; 1: focal haziness or even small patchy lesion; 2: ground glass picture; 3: lobar consolidation) according to the severity of infiltration in each lung field (three lung fields in both right and left lungs). The main outcome measurements were the improving chest radiographic scores (IRS) and the duration (days) till improvement (DI). One patient from the placebo group passed away. Patients from NHM A took less days before showing improvement (6.7 ± 1.8) compared with placebo group (11.2 ± 4.9), which showed statistical significance (P = 0.04). The cases were too few to be conclusive, the initial observations seem to indicate NHM appears to be safe in non-criticallly ill patients and clinical trials are feasible in the setting of pandemic outbreaks. url: https://www.ncbi.nlm.nih.gov/pubmed/18830453/ doi: 10.1093/ecam/nem035 id: cord-294959-xy8976jz author: Hsu, Elisabeth title: Allium fistulosum congee as a home remedy to ward off the corona virus at an early stage date: 2020-06-30 words: 976.0 sentences: 64.0 pages: flesch: 67.0 cache: ./cache/cord-294959-xy8976jz.txt txt: ./txt/cord-294959-xy8976jz.txt summary: title: Allium fistulosum congee as a home remedy to ward off the corona virus at an early stage Elisabeth Hsu a,* , Buxian Zhu b , Zewan Ding b , a Institute of Social and Cultural Anthropology, School of Anthropology and Museum Ethnography, University of Oxford, Oxford, UK b Chinese Medicine, Oxford, UK At the early stage of COVID-19, patients experience flu-like symptoms such as fever, chills, headaches, sore throat and etc. 3 Based on prior experience, several COVID-19 patients were successfully treated with Allium fistulosum congee. Two to three hours after the first taking of Allium fistulosum congee, the patient started to sweat with lots of phlegm coming out and the body temperature dropped from 38.5°C to 37.3°C. Other patients who were in the early or mild stage recovered much sooner, usually within three to four days taking Allium fistulosum congee. abstract: nan url: https://api.elsevier.com/content/article/pii/S2213422020300950 doi: 10.1016/j.imr.2020.100463 id: cord-254072-evgw0as5 author: Hsu, Li-Yang title: Severe Acute Respiratory Syndrome (SARS) in Singapore: Clinical Features of Index Patient and Initial Contacts date: 2003-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe acute respiratory syndrome (SARS) is an emerging viral infectious disease. One of the largest outbreaks of SARS to date began in Singapore in March 2003. We describe the clinical, laboratory, and radiologic features of the index patient and the patient’s initial contacts affected with probable SARS. url: https://www.ncbi.nlm.nih.gov/pubmed/12781012/ doi: 10.3201/eid0906.030264 id: cord-277739-eb4z3u66 author: Hu, Ke title: Efficacy and Safety of Lianhuaqingwen Capsules, a repurposed Chinese Herb, in Patients with Coronavirus disease 2019: A multicenter, prospective, randomized controlled trial date: 2020-05-16 words: 3665.0 sentences: 195.0 pages: flesch: 48.0 cache: ./cache/cord-277739-eb4z3u66.txt txt: ./txt/cord-277739-eb4z3u66.txt summary: title: Efficacy and Safety of Lianhuaqingwen Capsules, a repurposed Chinese Herb, in Patients with Coronavirus disease 2019: A multicenter, prospective, randomized controlled trial In the latest publication, Lianhuaqingwen (LH) capsule (Shijiazhuang Yiling Pharmaceutical Co. Ltd., Shijiazhuang, China) was a manufactured product of the traditional Chinese medicine formula marketed in China that could significantly inhibit SARS-CoV-2 replication, alter the viral morphology and confer anti-inflammatory activity in vitro . On the basis of usual treatment, we sought to explore the safety and efficacy of LH capsules in patients with Covid-19 by conducting a multicenter randomized controlled trial in mainland China. Eligibility criteria consisted of the following: 1) Laboratory-confirmed cases with according to the Protocol for Diagnosis and Treatment of Novel Coronarvirus Pneumonia (4 th edition) which was issued by the National Health Commission (General Office Of The National Health And Health Commission, 2020) (Panel 1); 2) Being symptomatic (either having fever, coughing, or fatigue) plus radiologic abnormalities consistent with pneumonia; 3) Patients aged 18 years or greater of either sex. abstract: BACKGROUND: Coronavirus disease 2019 (Covid-19) has resulted in a global outbreak. Few existing targeted medications are available. Lianhuaqingwen (LH) capsule, a repurposed marketed Chinese herb product, has been proven effective for influenza. PURPOSE: To determine the safety and efficacy of LH capsule in patients with Covid-19. METHODS: We did a prospective multicenter open-label randomized controlled trial on LH capsule in confirmed cases with Covid-19. Patients were randomized to receive usual treatment alone or in combination with LH capsules (4 capsules, thrice daily) for 14 days. The primary endpoint was the rate of symptom (fever, fatigue, coughing) recovery. RESULTS: We included 284 patients (142 each in treatment and control group) in the full-analysis set. The recovery rate was significantly higher in treatment group as compared with control group (91.5% vs. 82.4%, P=0.022). The median time to symptom recovery was markedly shorter in treatment group (median: 7 vs. 10 days, P<0.001). Time to recovery of fever (2 vs. 3 days), fatigue (3 vs. 6 days) and coughing (7 vs. 10 days) was also significantly shorter in treatment group (all P<0.001). The rate of improvement in chest computed tomographic manifestations (83.8% vs. 64.1%, P<0.001) and clinical cure (78.9% vs. 66.2%, P=0.017) was also higher in treatment group. However, both groups did not differ in the rate of conversion to severe cases or viral assay findings (both P>0.05). No serious adverse events were reported. CONCLUSION: In light of the safety and effectiveness profiles, LH capsules could be considered to ameliorate clinical symptoms of Covid-19. url: https://www.sciencedirect.com/science/article/pii/S0944711320300738?v=s5 doi: 10.1016/j.phymed.2020.153242 id: cord-336314-xf6zvvl8 author: Hu, Lijuan title: Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1186/s13054-020-02933-3 doi: 10.1186/s13054-020-02933-3 id: cord-311373-ngs7baoc author: Hu, Nannan title: Emergency Management of Mental Hospitals during the Outbreak of COVID-19 date: 2020-05-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.30773/pi.2020.0086 doi: 10.30773/pi.2020.0086 id: cord-277014-iz8jo44e author: Hu, Weihua title: Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study date: 2020-10-16 words: 3643.0 sentences: 202.0 pages: flesch: 43.0 cache: ./cache/cord-277014-iz8jo44e.txt txt: ./txt/cord-277014-iz8jo44e.txt summary: This study indicates that severity of the disease, the length of stay in the hospital of surviving patients, and mortality were higher among COVID-19 patients with sodium balance disorders. CONCLUSION: Sodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with COVID-19 in Hubei, China, and it is associated with a higher risk of severe illness and increased in-hospital mortality. reported hyponatremia to be much common (50%) amongst hospitalized COVID-19 patients in the United States [13] , and recently study further suggested that serum sodium concentration was inversely correlated with IL-6, and hyponatremia was associated with a more severe outcome of COVID-19 disease [14] . The associative disorders of serum sodium balance, their clinical characteristics, severity, and outcomes in SARS-CoV-2 infected patients have not been established. It was revealed that disease severity, the length of hospital stay for surviving patients, and mortality were high among COVID-19 patients with sodium balance disorders. abstract: BACKGROUND: The worldwide spread of SARS-CoV-2 has infected millions of people leading to over 0.3 million mortalities. The disruption of sodium homeostasis, tends to be a common occurrence in patients with COVID-19. METHODS AND RESULTS: A total of 1,254 COVID-19 patients comprising 124 (9.9%) hyponatremic patients (under 135 mmol/L) and 30 (2.4%) hypernatremic patients (over 145 mmol/L) from three hospitals in Hubei, China, were enrolled in the study. The relationships between sodium balance disorders in COVID-19 patients, its clinical features, implications, and the underlying causes were presented. Hyponatremia patients were observed to be elderly, had more comorbidities, with severe pneumonic chest radiographic findings. They were also more likely to have a fever, nausea, higher leukocyte and neutrophils count, and a high sensitivity C-reactive protein (HS-CRP). Compared to normonatremia patients, renal insufficiency was common in both hyponatremia and hypernatremia patients. In addition, hyponatremia patients required extensive treatment with oxygen, antibiotics, and corticosteroids. The only significant differences between the hypernatremia and normonatremia patients were laboratory findings and clinical complications, and patients with hypernatremia were more likely to use traditional Chinese medicine for treatment compared to normonatremia patients. This study indicates that severity of the disease, the length of stay in the hospital of surviving patients, and mortality were higher among COVID-19 patients with sodium balance disorders. CONCLUSION: Sodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with COVID-19 in Hubei, China, and it is associated with a higher risk of severe illness and increased in-hospital mortality. url: https://www.ncbi.nlm.nih.gov/pubmed/33064253/ doi: 10.1007/s11739-020-02515-9 id: cord-356215-0nypfw48 author: Hu, Xiaojing title: Management practices of emergency departments in general hospitals based on blockage of chain of infection during a COVID-19 epidemic date: 2020-09-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In a Coronavirus disease 2019 (COVID-19) epidemic, management of the emergency department is a difficult task in terms of prevention and control of the disease in general hospitals. On top of meeting urgent needs of patients for medical treatment, the emergency department also has to devote resources into investigation and prevention of COVID-19. At the beginning of the epidemic, with the strategy to intercept the chain of infection, Peking University First Hospital (PKUFH) focused on three important aspects: controlling the source of infection, cutting off the route of transmission, and protecting vulnerable populations, to expeditiously draft scientific and proper management measures for the emergency department, followed by real-time dynamic adjustments based on the development trend of the epidemic. These measures effectively ensured a smooth, orderly and safe operation of the emergency department. As of the writing of this manuscript, there has been no active COVID-19 infection in patients and medical staff in the emergency department, and no infection in patients admitted to PKUFH through the emergency department. This study describes the prevention and control measures in the emergency department of PKUFH during the outbreak of COVID-19, aiming to provide some reference for domestic and international medical institutions. url: https://www.ncbi.nlm.nih.gov/pubmed/32948990/ doi: 10.1007/s11739-020-02499-6 id: cord-313028-0nhgxoim author: Huang, Chaolin title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China date: 2020-01-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. METHODS: All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not. FINDINGS: By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα. INTERPRETATION: The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. FUNDING: Ministry of Science and Technology, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission. url: https://www.sciencedirect.com/science/article/pii/S0140673620301835 doi: 10.1016/s0140-6736(20)30183-5 id: cord-253962-ug7yflxh author: Huang, Dong title: A novel risk score to predict diagnosis with Coronavirus Disease 2019 (COVID‐19) in suspected patients: A retrospective, multi‐center, observational study date: 2020-06-08 words: 2459.0 sentences: 198.0 pages: flesch: 57.0 cache: ./cache/cord-253962-ug7yflxh.txt txt: ./txt/cord-253962-ug7yflxh.txt summary: title: A novel risk score to predict diagnosis with Coronavirus Disease 2019 (COVID‐19) in suspected patients: A retrospective, multi‐center, observational study BACKGROUND: The aim of the study was to explore a novel risk score to predict diagnosis with COVID‐19 among all suspected patients at admission. We found nine independent risk factors for diagnosis with COVID‐19 at admission to hospital: epidemiological exposure histories (OR:13.32, 95%CI 6.39‐27.75), weakness/fatigue (OR:4.51, 95%CI 1.70‐11.96), heart rate <100 beat/min (OR:3.80, 95%CI 2.00‐7.22), bilateral pneumonia (OR:3.60, 95%CI 1.83‐7.10), neutrophil count ≤6.3×10(9)/L (OR: 6.77, 95%CI 2.52‐18.19), eosinophil count ≤0.02×10(9)/L (OR:3.14, 95%CI 1.58‐6.22), glucose ≥6 mmol/L (OR:2.43, 95%CI 1.04‐5.66), D‐dimer ≥0.5 mg/L (OR:3.49, 95%CI 1.22‐9.96), and C‐reactive protein <5 mg/L (OR:3.83, 95%CI 1.86‐7.92). The current study is conducted aiming to explore the potential early risk factors, and to develop a risk score used for predicting the probability of diagnosis among all suspected COVID-19 patients at early stage. abstract: BACKGROUND: The aim of the study was to explore a novel risk score to predict diagnosis with COVID‐19 among all suspected patients at admission. METHODS: This was a retrospective, multi‐center, observational study. The clinical data of all suspected patients were analyzed. Independent risk factors were identified via multivariate logistic regression analysis. RESULTS: Finally, 336 confirmed COVID‐19 patients and 139 control patients were included. We found nine independent risk factors for diagnosis with COVID‐19 at admission to hospital: epidemiological exposure histories (OR:13.32, 95%CI 6.39‐27.75), weakness/fatigue (OR:4.51, 95%CI 1.70‐11.96), heart rate <100 beat/min (OR:3.80, 95%CI 2.00‐7.22), bilateral pneumonia (OR:3.60, 95%CI 1.83‐7.10), neutrophil count ≤6.3×10(9)/L (OR: 6.77, 95%CI 2.52‐18.19), eosinophil count ≤0.02×10(9)/L (OR:3.14, 95%CI 1.58‐6.22), glucose ≥6 mmol/L (OR:2.43, 95%CI 1.04‐5.66), D‐dimer ≥0.5 mg/L (OR:3.49, 95%CI 1.22‐9.96), and C‐reactive protein <5 mg/L (OR:3.83, 95%CI 1.86‐7.92). As for the performance of this risk score, a cut‐off value of 20 (specificity: 0.866, sensitivity: 0.813) was identified to predict COVID‐19 according to ROC curve and the area under the curve (AUC) was 0.921 (95%CI: 0.896‐0.945, p<0.01). CONCLUSIONS: We designed a novel risk score which might have a promising predictive capacity for diagnosis with COVID‐19 among suspected patients. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/jmv.26143 doi: 10.1002/jmv.26143 id: cord-009512-o4y9s8zf author: Huang, Jiajia title: Primary pulmonary non‐Hodgkin''s lymphoma: A retrospective analysis of 29 cases in a Chinese population date: 2010-03-24 words: 21926.0 sentences: 1115.0 pages: flesch: 51.0 cache: ./cache/cord-009512-o4y9s8zf.txt txt: ./txt/cord-009512-o4y9s8zf.txt summary: The authors in this study report the incidence and risk factors associated with the development of solid tumors in 4349 pediatric and adult patients who underwent allogeneic stem cell transplant (SCT) for acute myelogenous leukemia (AML) in CR1 or chronic myelogenous leukemia (CML) in first chronic phase. The lower hOCT1 mRNA expression level in LEU from IMA naïve de novo CML patients compared to healthy volunteers as well as its progressive increase after the start of IMA therapy could be explained by the initial presence and subsequent gradual disappearance of tumor cells from the measured cell population. To confirm this hypothesis, we performed an analysis on the relationship of hOCT1 expression with the percentage of immature myeloid cells in the LEU samples (as a marker of disease burden) obtained from IMA naïve de novo CML patients. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159398/ doi: 10.1002/ajh.21720 id: cord-294810-mq9vjnro author: Huang, Qiong title: Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China date: 2020-05-14 words: 3439.0 sentences: 195.0 pages: flesch: 52.0 cache: ./cache/cord-294810-mq9vjnro.txt txt: ./txt/cord-294810-mq9vjnro.txt summary: title: Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China Background Clinical characteristics of patients with the coronavirus disease 2019 (COVID-19) may present differently within and outside the epicenter of Wuhan, China. According to the clinical manifestations, the confirmed COVID-19 patients can be divided into mild, common, severe, and critical type groups based on the China National Health Commission Diagnosis and Treatment Plan of Novel Coronavirus Pneumonia (trial version 6) [7] . The blood test also showed that in general, patients with severe COVID-19 had worse results such as electrolyte and inflammatory biomarker abnormalities than those in patients with the common-type infection. In this study, we reported the clinical characteristics of patients with COVID-19 as well as therapies they received during hospitalization in Hunan province, China. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series abstract: Background Clinical characteristics of patients with the coronavirus disease 2019 (COVID-19) may present differently within and outside the epicenter of Wuhan, China. More clinical investigations are needed. Objective The study was aimed to describe the clinical characteristics, laboratory parameters, and therapeutic methods of COVID-19 patients in Hunan, China. Setting The First Hospital of Changsha, First People’s Hospital of Huaihua, and the Central Hospital of Loudi, Hunan province, China. Methods This was a retrospective multi-center case-series analysis. Patients with confirmed COVID-19 diagnosis hospitalized at the study centers from January 17 to February 10, 2020, were included. The following data were obtained from electronic medical records: demographics, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings, computer tomography scans, and treatment measures. Main outcome measure Epidemiological, clinical, laboratory, and radiological characteristics and treatments. Results A total of 54 patients were included (51 had the common-type COVID-19, three had the severe-type), the median age was 41, and 52% of them were men. The median time from the first symptoms to hospital admission was seven days. Among patients with the common-type COVID-19, the median length of stay was nine days, and 21 days among patients with severe COVID-19. The most common symptoms at the onset of illness were fever (74.5%), cough (56.9%), and fatigue (43.1%) among patients in the common-type group. Fourteen patients (37.8%) had a reduced WBC count, 23 (62.2%) had reduced eosinophil ratio, and 21 (56.76%) had decreased eosinophil count. The most common patterns on chest-computed tomography were ground-glass opacity (52.2%) and patchy bilateral shadowing (73.9%). Pharmacotherapy included recombinant human interferon α2b, lopinavir/ritonavir, novaferon, antibiotics, systematic corticosteroids and traditional Chinese medicine prescription. The outcome of treatment indicated that in patients with the common-type COVID-19, interferon-α2b, but not novaferon, had some benefits, antibiotics treatment was not needed, and corticosteroids should be used cautiously. Conclusion As of February 10, 2020, the symptoms of COVID-19 patients in Hunan province were relatively mild comparing to patients in Wuhan, the epicenter. We observed some treatment benefits with interferon-α2b and corticosteroid therapies but not with novaferon and antibiotic treatment in our study population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11096-020-01031-2) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32410206/ doi: 10.1007/s11096-020-01031-2 id: cord-285772-4xt4anq5 author: Huang, Rui title: Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study date: 2020-05-08 words: 3379.0 sentences: 217.0 pages: flesch: 59.0 cache: ./cache/cord-285772-4xt4anq5.txt txt: ./txt/cord-285772-4xt4anq5.txt summary: This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. Several studies have reported the clinical characteristics of COVID-19 patients who were hospitalized in Wuhan (the outbreak center of the infection) [4, 6, 7] . conducted a retrospective, single-center study which included 99 confirmed cases of COVID-19 in Wuhan and found that the virus was more likely to infect older men with comorbidities, and the mortality rate was as high as 11% [4] . Another single-center study which analyzed 138 hospitalized patients with confirmed COVID-19 in Wuhan, found that 26% of patients received ICU care and the mortality rate was only 4.3% [7] . In this multi-center study, we aimed to describe the clinical characteristics of COVID-19 and to identify the risk factors of severe illness among inpatients with confirmed COVID-19 in Jiangsu province, which is located in the east of China. abstract: Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. Clinical data of hospitalized COVID-19 patients were retrospectively collected in 8 hospitals from 8 cities of Jiangsu province, China. Clinical findings of COVID-19 patients were described and risk factors for severe illness of COVID-19 were analyzed. By Feb 10, 2020, 202 hospitalized patients with COVID-19 were enrolled. The median age of patients was 44.0 years (interquartile range, 33.0–54.0). 55 (27.2%) patients had comorbidities. At the onset of illness, the common symptoms were fever (156 [77.2%]) and cough (120 [59.4%]). 66 (32.7%) patients had lymphopenia. 193 (95.5%) patients had abnormal radiological findings. 11 (5.4%) patients were admitted to the intensive care unit and none of the patients died. 23 (11.4%) patients had severe illness. Severe illness of COVID-19 was independently associated with body mass index (BMI) ≥ 28 kg/m(2) (odds ratio [OR], 9.219; 95% confidence interval [CI], 2.731 to 31.126; P<0.001) and a known history of type 2 diabetes (OR, 4.326; 95% CI, 1.059 to 17.668; P = 0.041). In this case series in Jiangsu Province, COVID-19 patients had less severe symptoms and had better outcomes than the initial COVID-19 patients in Wuhan. The BMI ≥ 28 kg/m(2) and a known history of type 2 diabetes were independent risk factors of severe illness in patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32384078/ doi: 10.1371/journal.pntd.0008280 id: cord-310117-19qsszns author: Huang, Yao title: Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study date: 2020-06-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: Increasing data about COVID-19 have been acquired from the general population. We aim to further evaluate the clinical characteristics of COVID-19 in patients with systemic autoimmune diseases (AIDs). METHODS: We included all confirmed inpatients with COVID-19 and systemic AIDs in Wuhan Tongji Hospital from 29 January to 8 March 2020. We retrospectively collected and analysed information on epidemiology of 1255 inpatients and additional clinical characteristics of patients with systemic AIDs. Outcomes were followed up until 16 April 2020. RESULTS: Of the 1255 patients with COVID-19, the median age was 64.0 years and 53.1% were male. More than half (63.0%) had chronic comorbidities. The proportions of elderly, male and patients with comorbidities were significantly higher in intensive care unit (ICU) than in the general ward (p<0.001). 17 (0.61%) patients with systemic AIDs were further screened and analysed from 2804 inpatients. The median age was 64.0 years and 82.4% were female. All patients were living in Wuhan and two family clusters were found. 1 (5.9%) patient was admitted to ICU and one died. 10 (62.5%) of 16 patients changed or stopped their anti-AIDs treatments during hospitalisation, and 5 of them felt that the disease had worsened after the quarantine. CONCLUSIONS: Older males with chronic comorbidities are more vulnerable to severe COVID-19. The lower proportion of COVID-19 in patients with systemic AIDs needs more high-quality human clinical trials and in-depth mechanism researches. Of note, the withdrawal of anti-AIDs treatments during hospitalisation can lead to flares of diseases. url: https://doi.org/10.1136/annrheumdis-2020-217425 doi: 10.1136/annrheumdis-2020-217425 id: cord-347277-8bmcd22v author: Huang, Ying hui title: The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods date: 2020-04-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: The 2019 novel coronavirus (COVID-19) has continuous outbreaks around the world. Lung is the main organ that be involved. There is a lack of clinical data on the respiratory sounds of COVID-19 infected pneumonia, which includes invaluable information concerning physiology and pathology. The medical resources are insufficient, which are now mainly supplied for the severe patients. The development of a convenient and effective screening method for mild or asymptomatic suspicious patients is highly demanded. Methods: This is a retrospective case series study. 10 patients with positive results of nucleic acid were enrolled in this study. Lung auscultation was performed by the same physician on admission using a hand-held portable electronic stethoscope delivered in real time via Bluetooth. The recorded audio was exported, and was analyzed by six physicians. Each physician individually described the abnormal breathing sounds that he heard. The results were analyzed in combination with clinical data. Signal analysis was used to quantitatively describe the most common abnormal respiratory sounds. Results: All patients were found abnormal breath sounds at least by 3 physicians, and one patient by all physicians. Cackles, asymmetrical vocal resonance and indistinguishable murmurs are the most common abnormal breath sounds. One asymptomatic patient was found vocal resonance, and the result was correspondence with radiographic computed tomography. Signal analysis verified the credibility of the above abnormal breath sounds. Conclusions: This study describes respiratory sounds of patients with COVID-19, which fills up for the lack of clinical data and provides a simple screening method for suspected patients. url: https://doi.org/10.1101/2020.04.07.20051060 doi: 10.1101/2020.04.07.20051060 id: cord-303860-jpy373ph author: Huang, Zhifeng title: Occupational Exposure to SARS-CoV-2 in Burns Treatment During the COVID-19 Epidemic: Specific Diagnosis and Treatment Protocol date: 2020-04-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Epidemic prevention and control measures for the new coronavirus disease 2019 (COVID-19) has achieved significant results. As of 8 April 2020, 22,073 infection cases of COVID-19 among healthcare workers from 52 countries had been reported to WHO. COVID-19 has strong infectivity, high transmission speeds, and causes serious infection among healthcare worker. Burns are an acute-care condition, and burn treatment needs to be initiated before COVID-19 infection status can be excluded. The key step to infection prevention is to identify risk points of infection exposure, strengthen the protection against those risk points, and formulate an appropriate diagnosis and treatment protocol. Following an in-depth study of the latest literature on COVID-19 diagnosis and treatment, we reviewed the protocols surrounding hospitalization of patients with extensive burns (area≥50%) in our hospital from February 2009 to February 2019 and, in accordance with the epidemiological characteristics of COVID-19, developed an algorithm for protection during diagnosis and treatment of burns. Therefore, the aspects of medical protection and the diagnosis and treatment of burns appear to be particularly important during the prevention and control of the COVID-19. This algorithm was followed for 4 patients who received emergency treatment in February 2020 and were hospitalized. All healthcare worker were protected according to the three-tiered protective measures, and there was no nosocomial infection. During the COVID-19 epidemic, the early stages of emergency treatment for patients with extensive burns requiring the establishment of venous access for rehydration, endotracheal intubation or tracheostomy, wound treatment, and surgery are the risk points for exposure to infection. The implementation of effective, appropriate-grade protection and formulation of practical treatment protocols can increase protection of healthcare worke and reduce the risk of COVID-19 infection exposure. url: https://api.elsevier.com/content/article/pii/S0753332220303681 doi: 10.1016/j.biopha.2020.110176 id: cord-336438-mlgxiyur author: Huda, Farhanul title: Covid-19 and surgery: Challenging issues in the face of new normal – A narrative review date: 2020-10-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This review aims to outline the current perspectives of surgery in the COVID 19 pandemic associated with the pitfalls in implementing the emerging guidelines to continue patient care without compromising the safety, both from surgeons' and patients' points of view. The fight between the surgeon and the pandemic will be a dragging one since the post-pandemic efflux of the surgical patients coupled with the ‘new normal’ practices to prevent COVID 19 spread requires pertinent resources, well-trained personnel, and co-operation among different departments. Emergency surgeries and cancer care have continued all this while, undoubtedly, with unwanted delays and distress. While we continue to prepare ourselves and work in a whole new environment, surgeons are facing the increased chances of litigations and compromised safety. We review what we have come to understand about safe surgical practices during and after the pandemic and the unanswered questions. url: https://www.ncbi.nlm.nih.gov/pubmed/33133594/ doi: 10.1016/j.amsu.2020.10.039 id: cord-019046-q6uv2ayi author: Hughes, Amy L. title: Laryngeal Infections date: 2015-07-14 words: 3588.0 sentences: 202.0 pages: flesch: 44.0 cache: ./cache/cord-019046-q6uv2ayi.txt txt: ./txt/cord-019046-q6uv2ayi.txt summary: The chapter reviews the diagnostic approach to laryngeal infections, focusing on key points of the history and physical exam, including concerning signs and symptoms suggestive of airway distress. Viral and bacterial laryngitis, croup, epiglottis, recurrent respiratory papillomatosis, as well as some less common causes of bacterial infections are discussed in detail with each etiology''s epidemiology, clinical features, associated diagnostic evaluation, and management reviewed. The assessment of a patient with a suspected laryngeal infection should include a prompt evaluation for airway compromise focusing on stridor, increased work of breathing with retractions and accessory muscle use, and cyanosis. In the most severe cases of croup, patients may require direct laryngoscopy, bronchoscopy and intubation, although this is typically avoided as the endotracheal tube can contribute to the development of subglottic stenosis. There are several additional, however, less common causes of laryngeal infection that may present with airway symptoms. abstract: The following chapter is a review of the most common viral and bacterial etiologies of pediatric laryngeal infections. The chapter reviews the diagnostic approach to laryngeal infections, focusing on key points of the history and physical exam, including concerning signs and symptoms suggestive of airway distress. Viral and bacterial laryngitis, croup, epiglottis, recurrent respiratory papillomatosis, as well as some less common causes of bacterial infections are discussed in detail with each etiology’s epidemiology, clinical features, associated diagnostic evaluation, and management reviewed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124094/ doi: 10.1007/978-3-319-21744-4_11 id: cord-278477-9a7gmzz3 author: Huh, Kyungmin title: Impact of obesity, fasting plasma glucose level, blood pressure, and renal function on the severity of COVID-19: a matter of sexual dimorphism? date: 2020-10-21 words: 3233.0 sentences: 182.0 pages: flesch: 53.0 cache: ./cache/cord-278477-9a7gmzz3.txt txt: ./txt/cord-278477-9a7gmzz3.txt summary: Aims This study aimed to assess whether body mass index (BMI), fasting plasma glucose (FPG) levels, blood pressure (BP), and kidney function were associated with the risk of severe disease or death in patients with COVID-19. To examine the association between baseline health status and the risk of severe disease in patients with COVID-19, we performed a case-control study, using data from the nationwide registry of COVID-19 cases and from the biennial health checkup database in South Korea. In the present study based on a nationwide COVID-19 registry combined with an independent regular health checkup data, the effect of FPG levels and eGFR on the risk of severe or fatal COVID-19 varied between sex and age groups. In our retrospective study using a nationwide health checkup database, high FPG levels and low eGFR were significantly associated with the risk of severe COVID-19 (including fatal illness among women. abstract: Aims This study aimed to assess whether body mass index (BMI), fasting plasma glucose (FPG) levels, blood pressure (BP), and kidney function were associated with the risk of severe disease or death in patients with COVID-19. Methods Data on candidate risk factors were extracted from patients’ last checkup records. Propensity score-matched cohorts were constructed, and logistic regression models were used to adjust for age, sex, and comorbidities. The primary outcome was death or severe COVID-19, defined as requiring supplementary oxygen or higher ventilatory support. Results Among 7,649 patients with confirmed COVID-19, 2,231 (29.2%) received checkups and Severe COVID-19 occurred in 307 patients (13.8%). A BMI of 25.0–29.9 was associated with the outcome among women (aOR, 2.29; 95% CI,: 1.41–3.73) and patients aged 50–69 years (aOR, 1.64; 95% CI, 1.06–2.54). An FPG ≥126 mg/dL was associated with poor outcomes in women (aOR, 2.06; 95% CI, 1.13–3.77) but not in men. Similarly, estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 was a risk factor in women (aOR, 3.46; 95% CI, 1.71–7.01) and patients aged <70 years. Conclusions The effects of BMI, FPG, and eGFR on outcomes associated with COVID-19 were prominent in women but not in men. url: https://www.sciencedirect.com/science/article/pii/S0168822720307725?v=s5 doi: 10.1016/j.diabres.2020.108515 id: cord-268879-ajd7ofc8 author: Hui, David S. title: Contemporary Concise Review 2018: Respiratory infections and tuberculosis date: 2019-03-30 words: 3689.0 sentences: 192.0 pages: flesch: 39.0 cache: ./cache/cord-268879-ajd7ofc8.txt txt: ./txt/cord-268879-ajd7ofc8.txt summary: The huge clinical burden of common respiratory viruses, such as respiratory syncytial virus (RSV) and seasonal influenza, on healthcare resources and utilization highlights the importance for developing more effective treatment modalities in order to reduce morbidity and mortality. 20 The therapeutic role of baloxavir in older or immunocompromised patients with severe seasonal or avian A(H7N9) influenza especially with some time delay in administration of the drug later in the clinical course of the infection or in combination with an NAI requires investigation. While the sizeable protective effects of metformin in the abovementioned studies suggest a potential role of the drug as host-directed therapy in the treatment of latent TB infection and active TB, randomized trials are need to delineate its exact role(s) before introduction into clinical practices. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: impact of β-lactam plus macrolide combination therapy abstract: nan url: https://doi.org/10.1111/resp.13542 doi: 10.1111/resp.13542 id: cord-323255-elwfiima author: Huijskens, E. G. W. title: Evaluation of Patients with Community‐Acquired Pneumonia Caused by Zoonotic Pathogens in an Area with a High Density of Animal Farms date: 2015-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Intensive animal farming could potentially lead to outbreaks of infectious diseases. Clinicians are at the forefront of detecting unusual diseases, but the lack of specificity of zoonotic disease symptoms makes this a challenging task. We evaluated patients with community‐acquired pneumonia (CAP) with known and unknown aetiology in an area with a high livestock density and a potential association with animal farms in the proximity. Between 2008 and 2009, a period coinciding with a large Q fever outbreak in the Netherlands, patients with CAP were tested for the presence of possible respiratory pathogens. The presence and number of farm animals within 1 km of the patients' home address were assessed using geographic information system (GIS) and were compared between cases and age‐matched control subjects. Of 408 patients with CAP, pathogens were detected in 275 (67.4%) patients. The presence of sheep and the number of goats were associated with CAP caused by Coxiella burnetii in a multiple logistic regression model (P < 0.05). CAP with unknown aetiology was not associated with the presence of animal farms (P > 0.10). The use of GIS in combination with aetiology of CAP could be potentially used to target diagnostics and to identify outbreaks of rare zoonotic disease. url: https://doi.org/10.1111/zph.12218 doi: 10.1111/zph.12218 id: cord-286096-h275nner author: Huijskens, Elisabeth G. W. title: Viral and bacterial aetiology of community‐acquired pneumonia in adults date: 2012-08-22 words: 3714.0 sentences: 192.0 pages: flesch: 47.0 cache: ./cache/cord-286096-h275nner.txt txt: ./txt/cord-286096-h275nner.txt summary: Methods Between April 2008 and April 2009, 408 adult patients (aged between 20 and 94 years) with community‐acquired pneumonia were tested for the presence of respiratory pathogens using bacterial cultures, real‐time PCR for viruses and bacteria, urinary antigen testing for Legionella and Pneumococci and serology for the presence of viral and bacterial pathogens. All samples were tested using real-time PCR for the presence of respiratory viruses and bacteria including adenovirus (AdV), human bocavirus (hBoV), KI-and WU polyomaviruses (KIPyV and WUPyV), human metapneumovirus (hMPV), human rhinovirus (HRV), human coronaviruses (HCoV) (OC43, NL63, HKU and 229E), parainfluenza viruses (PIV), 1-4 influenza viruses A and B (InfA, InfB), respiratory syncytial virus (RSV), Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila psittaci, Chlamydophila pneumoniae, Coxiella burnetii and Streptococcus pneumoniae. This study revealed the viral and bacterial aetiology in 263 (64AE5%) of 408 patients with community-acquired pneumonia. abstract: Please cite this paper as: Huijskens et al. (2012) Viral and bacterial aetiology of community‐acquired pneumonia in adults. Influenza and Other Respiratory Viruses 7(4), 567–573. Background Modern molecular techniques reveal new information on the role of respiratory viruses in community‐acquired pneumonia. In this study, we tried to determine the prevalence of respiratory viruses and bacteria in patients with community‐acquired pneumonia who were admitted to the hospital. Methods Between April 2008 and April 2009, 408 adult patients (aged between 20 and 94 years) with community‐acquired pneumonia were tested for the presence of respiratory pathogens using bacterial cultures, real‐time PCR for viruses and bacteria, urinary antigen testing for Legionella and Pneumococci and serology for the presence of viral and bacterial pathogens. Results Pathogens were identified in 263 (64·5%) of the 408 patients. The most common single organisms in these 263 patients were Streptococcus pneumoniae (22·8%), Coxiella burnetii (6·8%) and influenza A virus (3·8%). Of the 263 patients detected with pathogens, 117 (44·5%) patients were positive for one or more viral pathogens. Of these 117 patients, 52 (44·4%) had no bacterial pathogen. Multiple virus infections (≥2) were found in 16 patients. Conclusion In conclusion, respiratory viruses are frequently found in patients with CAP and may therefore play an important role in the aetiology of this disease. url: https://doi.org/10.1111/j.1750-2659.2012.00425.x doi: 10.1111/j.1750-2659.2012.00425.x id: cord-276343-sb3vd7fq author: Humar, Atul title: Assessment of Adenovirus Infection in Adult Lung Transplant Recipients Using Molecular Surveillance date: 2006-12-31 words: 3526.0 sentences: 211.0 pages: flesch: 45.0 cache: ./cache/cord-276343-sb3vd7fq.txt txt: ./txt/cord-276343-sb3vd7fq.txt summary: [5] [6] [7] [8] Overall, lung transplant recipients with adenovirus infection appear to be at high risk for severe necrotizing pneumonitis, resulting in significant graft dysfunction and associated with high mortality. 9, 10 Infection of the allograft by adenovirus has also been associated with acute and chronic rejection and graft dysfunction in studies of lung and heart transplant recipients. 11, 12 However, recent data have suggested that adenovirus re-activation and viremia may be relatively common in transplant recipients and, in most cases, may not be associated with adverse clinical sequelae, especially if there is no evidence of allograft infection. In patients with detectable adenovirus viremia by PCR, clinical disease was attributed to adenovirus if detectable viremia was accompanied by compatible symptoms (including febrile illnesses, respiratory, gastrointestinal disease or evidence of infection of the allograft) in the absence of another defined etiology. abstract: Background Little is known about adenovirus infections in adult lung transplant recipients. Because the virus can establish latency, re-activation may be relatively common after transplantation. Methods We assessed adenovirus infection in 80 adult lung transplant recipients. Adenovirus polymerase chain reaction (real-time PCR assay; limit of detection ∼25 copies/ml plasma) was done on plasma samples collected at regular intervals until 1 year post-transplant. Results Adenovirus DNA was detected in 18 of 80 patients (22.5%) and in 19 of 595 (3.4%) plasma samples up to 12 months post-transplant. Median time to detection of viremia was 134 days post-transplant (range 1 to 370 days). Median viral load was 180 copies/ml plasma (range 50 to 360 copies/ml). Symptoms were evaluated at the time of adenovirus detection: 14 of 18 (78%) patients were asymptomatic; 4 of 18 (22%) patients had otherwise unexplained febrile/flu-like illness that resolved spontaneously. Adenovirus was not found to be a trigger for acute rejection. No detrimental effect on pulmonary function was seen immediately after adenovirus infection. Conclusions Adenovirus viremia is common in adult lung transplant recipients. In contrast to findings on adenoviral pneumonitis in lung transplant recipients, isolated episodes of low-level viremia are self-limited and do not trigger acute rejection or a decline in pulmonary function. url: https://www.ncbi.nlm.nih.gov/pubmed/17178339/ doi: 10.1016/j.healun.2006.09.015 id: cord-017227-66dx2dkv author: Humphreys, Hilary title: Immunocompromised Patients date: 2012-08-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The ominous prognosis of cancer patients with or without neutropenia in need of critical care has led to reservations with regard to admission of cancer patients to the ICU. However, significant improvements in ICU and in-hospital survival of cancer patients in ICU have been demonstrated in studies in recent years [1–4]. Risk factors for mortality have shifted from those related to the underlying condition to those related to the severity of acute illness similar to other critically-ill patients. Neutropenia per se and the underlying malignancy (solid and hematological) do not have an impact on the outcome of patients in ICU. Recent chemotherapy is associated rather with improved survival [3, 5–7], while organ dysfunction, severity of disease scores, need for vasopressor treatment, need for mechanical ventilation immediately or after noninvasive ventilation, no definite diagnosis and a non-infectious diagnosis are associated with mortality [1–3, 8]. Invasive aspergillosis is also associated with very high mortality rates in ICU (see below). In several studies, admission to ICU in the early stages of sepsis or other acute event was associated with better survival than admission later, after development of organ dysfunction. Performance status is perhaps the most important and only variable relating to the underlying condition that is correlated with ICU death. The prognosis remains guarded for certain cancer patients, including patients after allogeneic hematopoietic stem cell transplantation (HSCT) with active uncontrolled graft versus host disease, those with relapse of the primary disease after allogeneic HSCT and special cases of solid cancer including pulmonary carcinomatous lymphangitis and carcinomatous meningitis with coma [9]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121735/ doi: 10.1007/978-1-4471-4318-5_10 id: cord-018005-53cl75gk author: Humphreys, Hilary title: Lower Respiratory Tract Infections date: 2012-08-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Lower respiratory tract infections are common and are important in the critical care setting either because they precipitate admission to the critical care unit, e.g. severe viral pneumonia or because they complicate the course of a patient with significant underlying disease or following major surgery, e.g. after multiple trauma. Furthermore, respiratory failure requiring artifical ventialtion is a well recognised reason for critical care support but it can be difficult to determine if this is due to an underlying non-infectious condition such as chronic obstructive pulmonary disease (COPD), infection or a combination of both. The early diagnosis and management of respiratory infection combined with appropriate ventilatory support aids prognosis and the efficient use of critical care facilities given the number of patients affected. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122728/ doi: 10.1007/978-1-4471-4318-5_6 id: cord-353375-92pu0pp0 author: Hung, Jennifer C. H. title: Implications of COVID-19 for uveitis patients: perspectives from Hong Kong date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1038/s41433-020-0905-1 doi: 10.1038/s41433-020-0905-1 id: cord-271149-qnhlfozo author: Huo, Xiang title: Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014 date: 2016-09-01 words: 3679.0 sentences: 193.0 pages: flesch: 46.0 cache: ./cache/cord-271149-qnhlfozo.txt txt: ./txt/cord-271149-qnhlfozo.txt summary: Disease severity, proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient''s direct medical cost of hospitalization. The mean direct cost of hospitalization with H7N9 (US$ 10 969) estimated in this research is much higher than that of hospitalization There are 1, 7 and 3 missing data in District, Health insurance and Family member monthly average income respectively associated with seasonal influenza (US$ 1 797) [11] and the healthcare costs per patient with severe acute respiratory syndrome (SARS) in Beijing (US$ 1 886) most likely due to higher rates of ICU admission and death [12, 13] and the use of more expensive modern medical devices [14] . The mean direct medical costs of hospitalized H7N9 patients were found to be ¥12 060 (US$1 861), ¥136 120 (US$21 006) and ¥218 610 (US$33 736) (estimated by model), or ¥12 790 (US$1 974), ¥96 780 (US$14 935) and ¥228 650 (US$35 285) (medians observed) for mild, severe and dead cases respectively in this study. abstract: BACKGROUND: H7N9 continues to cause human infections and remains a pandemic concern. Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation, including infectious disease prevention and control investment. However, there are limited data on such impacts. METHODS: Hospitalized laboratory-confirmed H7N9 patients or their families in Jiangsu Province of China were interviewed. Patients’ direct medical costs of hospitalization were derived from their hospital bills. A generalized linear model was employed to estimate the mean direct medical costs of patients with different characteristics. RESULTS: The mean direct cost of hospitalization for H7N9 was estimated to be ¥ 71 060 (95 % CI, 48 180–104 820), i.e., US$ 10 996 (95 % CI, 7 455–16 220), and was ¥12 060 (US$ 1 861), ¥136 120 (US$ 21 001) and ¥218 610 (US$ 33 728) for those who had mild or severe symptoms or who died, respectively. The principal components of the total fees differed among patients with different disease severity, although medication fees were always the largest contributors. Disease severity, proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient’s direct medical cost of hospitalization. CONCLUSIONS: The direct medical costs of hospitalized patients with H7N9 are significant, and far surpass the annual per capita income of Jiangsu Province, China. The influencing factors identified should be taken into account when developing related health insurance policies and making health resource allocation. TRIAL REGISTRATION: Not applicable. This is a survey study with no health care intervention implemented on human participants. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40249-016-0170-5) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1186/s40249-016-0170-5 doi: 10.1186/s40249-016-0170-5 id: cord-016127-tbot0fc9 author: Hurtado, F. J. title: Sepsis: Clinical Approach, Evidence-Based at the Bedside date: 2009-11-19 words: 4875.0 sentences: 315.0 pages: flesch: 44.0 cache: ./cache/cord-016127-tbot0fc9.txt txt: ./txt/cord-016127-tbot0fc9.txt summary: Since 2002 the Surviving Sepsis Campaign was introduced with the initial goal of increasing clinicians'' awareness about severe sepsis mortality and to improve outcome in this patient population. Despite the fact that most of these recommendations were not supported by high levels of evidence, they represented the international consensus on the best available standards of care for the management of sepsis. Mortality increases according to the presence of shock, and metabolic markers like arterial lactate are useful to characterize disease severity and the response to treatment [8] . The current management of severe sepsis and septic shock aims to control infection, achieve hemodynamic stabilization, modulate the immune response, and provide metabolic and organ support. The SSC is a global initiative that involves several international organizations with the common objective of elaborating evidence-based guidelines and recommendations for the management of severe sepsis and septic shock. Early goal-directed therapy in the treatment of severe sepsis and septic shock abstract: Sepsis is a common disease in intensive care medicine representing almost one third of patient admissions. Its incidence has substantially increased over the past decades and overall mortality has declined during this period of time. It was reported that sepsis incidence increased from 82.7 to 240.4 per 100,000 population between 1979–2000. At the same time, sepsis global mortality decreased from 27.8 to 17.9% [1–3]. However, the absolute number of deaths significantly increased from 21.9 to 43.9 per 100,000 population. Male gender, some chronic diseases like diabetes, immunosuppressive states, human immunodeficiency virus infections, and malignancies are factors that increase the risk for sepsis. Some particular conditions like progressive number of organ dysfunctions, in-hospital-acquired infections and increasing age are associated with higher risk of death [1,4]. On the other hand, septic shock mortality only diminished from 61.6 to 53.1% [5]. This slight decline in mortality observed during recent decades could be attributable to improvements in supportive care and/or avoidance of iatrogenic complications. For example, the instrumentation of early goal resuscitation protocols not aiming at supranormal targets for cardiac output and oxygen delivery, and the use of lung protective strategies could explain at least in part this favorable change. Other strategies directed to treat the pathophysiological mechanisms involved in the septic process like recombinant human-activated protein-C (rhAPC), have also contributed to improve survival. However, mortality remains unacceptably high and further improvement in sepsis management is needed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120313/ doi: 10.1007/978-88-470-1436-7_25 id: cord-269554-fzu6dy4e author: Hussein, M. H. title: Asthma in COVID-19: An extra chain fitting around the neck? date: 2020-07-15 words: 3091.0 sentences: 198.0 pages: flesch: 51.0 cache: ./cache/cord-269554-fzu6dy4e.txt txt: ./txt/cord-269554-fzu6dy4e.txt summary: Univariate analysis of COVID-19 outcomes revealed that asthma was significantly associated with higher rate of endotracheal intubation (40.3% vs 27.8%, p = 0.036), mechanical ventilation (both invasive and non-invasive) (70.7% vs 52.2%, p = 0.039), and longer hospital length of stay (15.14 ± 12.48 days vs 11.51 ± 10.58 days, p = 0.015). Asthma was not associated with a higher rate of Intensive Care Unit (ICU) admission (22.2% vs 14.9%, p = 0.12), acute respiratory distress syndrome (37.5% vs 30.9%, p = 0.27), or death (9.7% vs 13.5%, p = 0.45) among COVID-19 patients. On comparison to non-asthmatic obese patients, obese asthmatic patients were more likely to develop sepsis (25.9% vs 14.2%, p = 0.042), had higher risk of ICU admission (48.1% vs 33.2%, p = 0.042), and required prolonged intubation (2.73 ± 3.63 days vs 1.38 ± 2.07, p = 0.032).Impact of asthma comorbidity on COVID-19 outcomes abstract: Introduction The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe, overwhelming healthcare systems and depleting resources. The infection has a wide spectrum of presentations, and pre-existing comorbidities have been found to have a dramatic effect on the disease course and prognosis. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. Methods We conducted a multi-center retrospective study of positively confirmed COVID-19 patients from multiple hospitals in Louisiana. Demographics, medical history, comorbidities, clinical presentation, daily laboratory values, complications, and outcomes data were collected and analyzed. The primary outcome of interest was in-hospital mortality. Secondary outcomes were Intensive Care Unit (ICU) admission, risk of intubation, duration of mechanical ventilation, and length of hospital stay. Results A total of 502 COVID-19 patients (72 asthma and 430 non-asthma cohorts) were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%, higher than the national prevalence of asthma (7.7%). Univariate analysis revealed that asthma patients were more likely to be obese (75% vs 54.2%, p=0.001), with higher frequency of intubation (40.3% vs 27.8%, p = 0.036), and required longer duration of hospitalization (15.1{+/-}12.5 vs 11.5{+/-}10.6, p=0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR=1.81, 95%CI=0.98-3.09, p=0.06), endotracheal intubation (OR=1.77, 95%CI=0.99-3.04, p=0.06) or complications (OR=1.37, 95%CI=0.82-2.31, p=0.23). Asthmatic patients were not associated with higher odds of prolonged hospital length of stay (OR=1.48, 95%CI=0.82-2.66, p=0.20) or with the duration of ICU stay (OR=0.76, 95%CI=0.28-2.02, p=0.58). Kaplan-Meier curve showed no significant difference in overall survival of the two groups (p=0.65). Conclusion Despite the increased prevalence of hospitalization in asthmatic COVID-19 patients compared to the general population, after adjustment for other variables, it was neither associated with increased severity nor worse outcomes. url: https://doi.org/10.1101/2020.07.13.20153130 doi: 10.1101/2020.07.13.20153130 id: cord-333175-klnxnxwm author: Hussein, Mohammad H. title: Asthma in COVID-19 patients: An extra chain fitting around the neck? date: 2020-11-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. Pre-existing comorbidities have been found to have a dramatic effect on the disease course. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. METHODS: We conducted a multi-center retrospective study of positively confirmed COVID-19 patients. The primary outcome of interest was in-hospital mortality. Secondary outcomes were the Intensive Care Unit (ICU) admission, intubation, mechanical ventilation, and length of hospital stay. RESULTS: A total of 502 COVID-19 adult patients (72 asthma and 430 non-asthma cohorts) with mean age of 60.7 years were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%. Univariate analysis revealed that asthma patients were more likely to be obese (75% versus 54.2%, p = 0.001), with a higher frequency of intubation (40.3% versus 27.8%, p = 0.036), and required a longer duration of hospitalization (15.1 ± 12.5 versus 11.5 ± 10.6, p = 0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR = 1.81, 95%CI = 0.98–3.09, p = 0.06), endotracheal intubation (OR = 1.77, 95%CI = 0.99–3.04, p = 0.06) or complications (OR = 1.37, 95%CI = 0.82–2.31, p = 0.23). Asthmatic patients were not associated with higher odds of prolonged hospital length of stay (OR = 1.48, 95%CI = 0.82–2.66, p = 0.20) or with ICU stay (OR = 0.76, 95%CI = 0.28–2.02, p = 0.58). Kaplan-Meier curve showed no significant difference in the overall survival of the two groups (p = 0.65). CONCLUSION: Despite the increased prevalence of hospitalization in elder asthmatic COVID-19 patients, after adjustment for other variables, it was neither associated with increased severity nor worse outcomes. url: https://www.sciencedirect.com/science/article/pii/S0954611120303450?v=s5 doi: 10.1016/j.rmed.2020.106205 id: cord-275257-upj8mvzn author: Hwang, E. Shelley title: Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change date: 2020-06-14 words: 8495.0 sentences: 389.0 pages: flesch: 40.0 cache: ./cache/cord-275257-upj8mvzn.txt txt: ./txt/cord-275257-upj8mvzn.txt summary: Perspectives are provided on: (1) maintaining a safe environment for surgical oncology care; (2) redirecting the multidisciplinary model to guide surgical decisions; (3) harnessing telemedicine to accommodate requisite physical distancing; (4) understanding interactions between SARS CoV-2 and cancer therapy; (5) considering the ethical impact of professional guidelines for surgery prioritization; and (6) advocating for our patients who require oncologic surgery in the midst of the COVID-19 pandemic. The panel provides perspectives on: (1) creating a safe environment for surgical oncology care, (2) redirecting the multidisciplinary model to guide surgical decisions, (3) harnessing telemedicine to accommodate requisite physical distancing, (4) understanding interactions between SARS CoV-2 and cancer therapy, (5) considering the ethical impact of professional guidelines for surgery prioritization, and (6) advocating for our patients who require oncologic surgery in the midst of the COVID-19 pandemic. abstract: BACKGROUND: The COVID-19 pandemic has posed extraordinary demands from patients, providers, and health care systems. Despite this, surgical oncologists must maintain focus on providing high-quality, empathetic care for the almost 2 million patients nationally who will be diagnosed with operable cancer this year. The focus of hospitals is transitioning from initial COVID-19 preparedness activities to a more sustained approach to cancer care. METHODS: Editorial Board members provided observations of the implications of the pandemic on providing care to surgical oncology patients. RESULTS: Strategies are presented that have allowed institutions to successfully prepare for cancer care during COVID-19, as well as other strategies that will help hospitals and surgical oncologists manage anticipated challenges in the near term. Perspectives are provided on: (1) maintaining a safe environment for surgical oncology care; (2) redirecting the multidisciplinary model to guide surgical decisions; (3) harnessing telemedicine to accommodate requisite physical distancing; (4) understanding interactions between SARS CoV-2 and cancer therapy; (5) considering the ethical impact of professional guidelines for surgery prioritization; and (6) advocating for our patients who require oncologic surgery in the midst of the COVID-19 pandemic. CONCLUSIONS: Until an effective vaccine becomes available for widespread use, it is imperative that surgical oncologists remain focused on providing optimal care for our cancer patients while managing the demands that the COVID-19 pandemic will continue to impose on all of us. url: https://doi.org/10.1245/s10434-020-08673-6 doi: 10.1245/s10434-020-08673-6 id: cord-340826-2530zdeq author: Hwang, Jong-moon title: Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death. METHODS: In this retrospective cohort study, we included 103 adult inpatients (aged ≥ 18 years). We evaluated differences in demographic data between surviving and non-surviving COVID-19 patients. RESULTS: In a multivariate logistic analysis, age and the presence of chronic lung disease and Alzheimer’s dementia (AD) were the only significant parameters for predicting COVID-19 non-survival (p < 0.05). However, hypertension, coronary vascular disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not significantly associated with the death of COVID-19 patients. The optimal cutoff value obtained from the maximum Youden index was 70 (sensitivity, 80.77%; specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for every year of age. CONCLUSIONS: Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD. url: https://doi.org/10.1007/s10072-020-04541-z doi: 10.1007/s10072-020-04541-z id: cord-340880-2qop8tcp author: Hyman, Jaime B. title: Timing of Intubation and In-Hospital Mortality in Patients With Coronavirus Disease 2019 date: 2020-10-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To examine whether increasing time between admission and intubation was associated with mortality in patients with coronavirus disease 2019 who underwent mechanical ventilation. DESIGN: Retrospective cohort study of patients with severe acute respiratory syndrome coronavirus 2 infection who were admitted between January 30, 2020, and April 30, 2020, and underwent intubation and mechanical ventilation prior to May 1, 2020. Patients were followed up through August 15, 2020. SETTING: Five hospitals within the Mount Sinai Health System in New York City, NY. PATIENTS: Adult patients with severe acute respiratory syndrome coronavirus 2 infection who underwent intubation and mechanical ventilation. INTERVENTIONS: Tracheal intubation and mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: The primary outcome was in-hospital mortality. A hospital-stratified time-varying Cox model was used to evaluate the effect of time from admission to intubation on in-hospital death. A total of 755 adult patients out of 5,843 admitted with confirmed severe acute respiratory syndrome coronavirus 2 infection underwent tracheal intubation and mechanical ventilation during the study period. The median age of patients was 65 years (interquartile range, 56–72 yr) and 64% were male. As of the time of follow-up, 121 patients (16%) who were intubated and mechanically ventilated had been discharged home, 512 (68%) had died, 113 (15%) had been discharged to a skilled nursing facility, and 9 (1%) remained in the hospital. The median time from admission to intubation was 2.3 days (interquartile range, 0.6–6.3 d). Each additional day between hospital admission and intubation was significantly associated with higher in-hospital death (adjusted hazard ratio, 1.03; 95% CI, 1.01–1.05). CONCLUSIONS: Among patients with coronavirus disease 2019 who were intubated and mechanically ventilated, intubation earlier in the course of hospital admission may be associated with improved survival. url: https://doi.org/10.1097/cce.0000000000000254 doi: 10.1097/cce.0000000000000254 id: cord-320612-vam0bli3 author: Höring, Steffen title: Management of a Hospital-Wide COVID-19 Outbreak Affecting Patients and Healthcare Workers date: 2020-10-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: To the best of our knowledge, here, we describe the first hospital-wide outbreak of SARS-CoV-2 that occurred in Germany in April 2020. We aim to share our experience in order to facilitate the management of nosocomial COVID-19 outbreaks in healthcare facilities. All patients and hospital workers were screened for SARS-CoV-2 repeatedly. An infection control team on the side was installed. Strict spatial separation of patients and intensified hygiene training of healthcare workers (HCW) were initiated. By the time of reporting, 26 patients and 21 hospital workers were infected with a cluster of cases in the geriatric department. Fourteen patients developed COVID-19 consistent symptoms and five patients with severe pre-existing medical conditions died. The outbreak was successfully contained after intensified infection control measures were implemented and no further cases among patients were detected over a period of 14 days. Strict application of standard infection control measures proved to be successful in the management of nosocomial SARS-CoV-2 outbreaks. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s42399-020-00597-2) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s42399-020-00597-2 doi: 10.1007/s42399-020-00597-2 id: cord-328289-3h3kmjlz author: Iadecola, Costantino title: Effects of COVID-19 on the nervous system date: 2020-08-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Summary Neurological complications have emerged as a significant cause of morbidity and mortality in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized patients exhibit neurological manifestations, ranging from headache and loss of smell, to confusion and disabling strokes. COVID-19 is also anticipated to take a toll on the nervous system in the long term. Here we will provide a critical appraisal of the potential for neurotropism and mechanisms of neuropathogenesis of SARS-CoV-2, as they relate to the acute and chronic neurological consequences of the infection. Finally, we will examine potential avenues for future research and therapeutic development. url: https://api.elsevier.com/content/article/pii/S0092867420310709 doi: 10.1016/j.cell.2020.08.028 id: cord-348855-lnltoj1n author: Iannaccone, Giulia title: Weathering the Cytokine Storm in COVID-19: Therapeutic Implications date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged in Wuhan, Hubei-China, as responsible for the coronavirus disease 2019 (COVID-19) and then spread rapidly worldwide. While most individuals remain asymptomatic or develop only mild symptoms, approximately 5% develop severe forms of COVID-19 characterized by acute respiratory distress syndrome (ARDS) and multiple-organ failure (MOF) that usually require intensive-care support and often yield a poor prognosis. SUMMARY: The pathophysiology of COVID-19 is far from being completely understood, and the lack of effective treatments leads to a sense of urgency to develop new therapeutic strategies based on pathophysiological assumptions. The exaggerated cytokine release in response to viral infection, a condition known as cytokine release syndrome (CRS) or cytokine storm, is emerging as the mechanism leading to ARDS and MOF in COVID-19, thus endorsing the hypothesis that properly timed anti-inflammatory therapeutic strategies could improve patients' clinical outcomes and prognosis. KEY MESSAGES: The objective of this article is to explore and comment on the potential role of the promising immunomodulatory therapies using pharmacological and nonpharmacological approaches to overcome the dysregulated proinflammatory response in COVID-19. url: https://doi.org/10.1159/000509483 doi: 10.1159/000509483 id: cord-328487-glwslgjy author: Iannaccone, Sandro title: ROLE OF REHABILITATION DEPARTMENT FOR ADULT COVID-19 PATIENTS: THE EXPERIENCE OF THE SAN RAFFAELE HOSPITAL OF MILAN date: 2020-06-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The rapid evolution of the health emergency linked to the spread of SARS-CoV-2 requires specifications for the rehabilitative management of COVID-19 patients. The symptomatic evolution of COVID-19 patients is characterized by two phases: an acute phase in which respiratory symptoms prevail, and a post-acute phase in which patients can show symptoms related to prolonged immobilization, to previous and current respiratory dysfunctions as well as cognitive and emotional disorders. There is thus the need for specialized rehabilitative care for these patients. This communication reports the experience of the San Raffaele Hospital of Milan (Italy) and recommends the set-up of specialized clinical pathways for the rehabilitation of COVID-19 patients. In this hospital, between February 1st and March 2nd 2020, about 50 patients were admitted every day with COVID-19 symptoms. In those days, about 400 acute care beds were created (Intensive Care/Infectious Diseases). In the following 30 days, from March 2nd to mid-April, despite the presence of 60 daily arrivals to the ER, the organization of patient flow between different wards was modified and several different units were created based on a more accurate integration of patients’ needs. According to this new organization, patients were admitted first to acute care COVID-19 units, and then to COVID-19 rehabilitation units, post-COVID-19 rehabilitation units and/or quarantine/observation units. After hospital discharge, telemedicine was used to follow-up with patients at home. Such clinical pathways should each involve dedicated multidisciplinary teams composed of pulmonologists, physiatrists, neurologists, cardiologists, physiotherapists, neuropsychologists, occupational therapists, speech therapists and nutritionists. url: https://api.elsevier.com/content/article/pii/S0003999320303658 doi: 10.1016/j.apmr.2020.05.015 id: cord-317344-wznzmssz author: Iannitti, T. title: Therapeutical use of probiotic formulations in clinical practice date: 2010-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND & AIMS: The spreading of gastrointestinal diseases is growing all over the world. Although for some of them an effective therapeutic approach has been found, palliation rather than cure is very frequent due to a partial knowledge of their aethiology and pathogenesis. This review, analyzing the main clinical studies, aims at being a state of the art update of the use of probiotic formulations in daily practice. METHODS: In this review we include all the most significant clinical trials involving the use of probiotic formulations for the treatment of several pathologies. RESULTS: Dysbiosis has been observed in irritable bowel syndrome patients. Probiotics may exert a beneficial effect on Crohn’s disease affected patients who have shown gut microbiota antigens and altered wall permeability. Moreover some probiotic formulations seem to enhance the therapy for Helycobacter Pylori reducing its pathogenic potential. Intestinal ecology imbalance has been also linked to cancer induction, allergy, skin and urogenital diseases. In addition probiotics administration seems to be particularly useful to ease post-operative complications. CONCLUSION: Further future clinical trials, involving large numbers of patients, will be mandatory to achieve definite evidence of the preventive and curative role of probiotics in medical practice. url: https://www.ncbi.nlm.nih.gov/pubmed/20576332/ doi: 10.1016/j.clnu.2010.05.004 id: cord-349408-2ser9zjc author: Iannuzzi, Nicholas P. title: An Orthopaedic Department’s Response to the COVID-19 Health-Care Crisis: Indirect and Direct Actions with Thoughts for the Future date: 2020-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.2106/jbjs.20.00611 doi: 10.2106/jbjs.20.00611 id: cord-273426-55vu6b3u author: Iba, Toshiaki title: Coagulopathy of Coronavirus Disease 2019 date: 2020-05-26 words: 4536.0 sentences: 257.0 pages: flesch: 31.0 cache: ./cache/cord-273426-55vu6b3u.txt txt: ./txt/cord-273426-55vu6b3u.txt summary: Conclusions: Severe acute respiratory syndrome coronavirus 2/ coronavirus disease 2019 frequently induces hypercoagulability with both microangiopathy and local thrombus formation, and a systemic coagulation defect that leads to large vessel thrombosis and major thromboembolic complications, including pulmonary embolism in critically ill hospitalized patients. Conclusions: Severe acute respiratory syndrome coronavirus 2/ coronavirus disease 2019 frequently induces hypercoagulability with both microangiopathy and local thrombus formation, and a systemic coagulation defect that leads to large vessel thrombosis and major thromboembolic complications, including pulmonary embolism in critically ill hospitalized patients. (Crit Care Med 2020; XX:00-00) Key Words: coagulopathy; coronavirus; coronavirus disease 2019; disseminated intravascular coagulation; hypercoagulability; thromboembolism I ncreasing communications worldwide have reported that hospitalized, critically ill coronavirus disease 2019 (COVID-19) patients are frequently developing laboratory abnormalities compatible with hypercoagulability and clinically a high prevalence of thromboembolic events (1). abstract: Recent studies have reported a high prevalence of thrombotic events in coronavirus disease 2019. However, the significance of thromboembolic complications has not been widely appreciated. The purpose of this review is to provide current knowledge of this serious problem. DESIGN: Narrative review. DATA SOURCES: Online search of published medical literature through PubMed using the term “COVID-19,” “SARS,” “acute respiratory distress syndrome,” “coronavirus,” “coagulopathy,” “thrombus,” and “anticoagulants.” STUDY SELECTION AND DATA EXTRACTION: Articles were chosen for inclusion based on their relevance to coagulopathy and thrombosis in coronavirus disease 2019, and anticoagulant therapy. Reference lists were reviewed to identify additional relevant articles. DATA SYNTHESIS: Coronavirus disease 2019 is associated with a strikingly high prevalence of coagulopathy and venous thromboembolism that may contribute to respiratory deterioration. Monitoring coagulation variables is important, as abnormal coagulation tests are related to adverse outcomes and may necessitate adjuvant antithrombotic interventions. In the initial phase of the infection, d-dimer and fibrinogen levels are increased, while activated partial prothrombin time, prothrombin time, and platelet counts are often relatively normal. Increased d-dimer levels three times the upper limit of normal may trigger screening for venous thromboembolism. In all hospitalized patients, thromboprophylaxis using low-molecular-weight heparin is currently recommended. The etiology of the procoagulant responses is complex and thought to be a result of specific interactions between host defense mechanisms and the coagulation system. Although the coagulopathy is reminiscent of disseminated intravascular coagulation and thrombotic microangiopathy, it has features that are markedly distinct from these entities. CONCLUSIONS: Severe acute respiratory syndrome coronavirus 2/coronavirus disease 2019 frequently induces hypercoagulability with both microangiopathy and local thrombus formation, and a systemic coagulation defect that leads to large vessel thrombosis and major thromboembolic complications, including pulmonary embolism in critically ill hospitalized patients. d-dimers and fibrinogen levels should be monitored, and all hospitalized patients should undergo thromboembolism prophylaxis with an increase in therapeutic anticoagulation in certain clinical situations. url: https://www.ncbi.nlm.nih.gov/pubmed/32467443/ doi: 10.1097/ccm.0000000000004458 id: cord-312684-3i2r2ahr author: Iba, Toshiaki title: Coagulopathy in COVID‐19 date: 2020-06-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID‐19 pandemic has become an urgent issue in every country. Based on recent reports, the most severely ill patients present with coagulopathy, and disseminated intravascular coagulation (DIC)‐like massive intravascular clot formation is frequently seen in this cohort. Therefore, coagulation tests may be considered useful to discriminate severe cases of COVID‐19. The clinical presentation of COVID‐19‐associated coagulopathy is organ dysfunction primarily, while hemorrhagic events are less frequent. Changes in hemostatic biomarkers represented by increase in D‐dimer and fibrin/fibrinogen degradation products indicate the essence of coagulopathy is massive fibrin formation. In comparison with bacterial‐sepsis‐associated coagulopathy/DIC, prolongation of prothrombin time, and activated partial thromboplastin time, and decrease in antithrombin activity is less frequent and thrombocytopenia is relatively uncommon in COVID‐19. The mechanisms of the coagulopathy are not fully elucidated, however. It is speculated that the dysregulated immune responses orchestrated by inflammatory cytokines, lymphocyte cell‐death, hypoxia, and endothelial damage are involved. Bleeding tendency is uncommon, but the incidence of thrombosis in COVID‐19 and the adequacy of current recommendations regarding standard venous thromboembolic dosing are uncertain. url: https://www.ncbi.nlm.nih.gov/pubmed/32558075/ doi: 10.1111/jth.14975 id: cord-002145-yq7iwp42 author: Ibrahim, Ahmed title: Clinical profile and outcome of patients with acute kidney injury requiring dialysis—an experience from a haemodialysis unit in a developing country date: 2016-07-22 words: 2712.0 sentences: 139.0 pages: flesch: 52.0 cache: ./cache/cord-002145-yq7iwp42.txt txt: ./txt/cord-002145-yq7iwp42.txt summary: title: Clinical profile and outcome of patients with acute kidney injury requiring dialysis—an experience from a haemodialysis unit in a developing country This study was conducted to describe the clinical profile and outcome of adult Acute Kidney Injury (AKI) patients treated with intermittent haemodialysis at the dialysis center of SPHMMC. The aim of this study is to describe the clinical profile and outcome of all adult AKI patients treated with intermittent haemodialysis at the unit in the first 18 months since its establishment. The medical record numbers of all patients dialyzed during the study period were identified from the dialysis unit log book and the clinical records retrieved from the hospital record office. Though difficult to accurately diagnose in our setup due to lack of availability of renal biopsy, AGN (diagnosed through clinical means) was found to be a common cause of AKI requiring dialysis. abstract: BACKGROUND: The first government funded and sustainable dialysis unit was established in Ethiopia at Saint Paul’s Hospital Millennium Medical College (SPHMMC). This has led to the development of a unique cohort of patients about which very little is known. This study was conducted to describe the clinical profile and outcome of adult Acute Kidney Injury (AKI) patients treated with intermittent haemodialysis at the dialysis center of SPHMMC. METHODS: A retrospective review of clinical records of cases of AKI who required haemodialysis support during the time period from August 1, 2013 to February 1, 2015 was conducted. RESULTS: A total of 151 cases AKI requiring dialysis were included for the study. Overall, the patients were generally younger with a mean age of 36.7 years and thus with few premorbid conditions. The most common causes of AKI were hypovolemia (22.5 %), acute glomerulonephritis (AGN) (21.9 %) and pregnancy related causes (18.5 %). Nearly a third (29.1 %) of patients succumbed to the AKI. CONCLUSION: Infections, AGN, obstetric causes and nephrotoxins were the primary causes of dialysis requiring AKI. Most of these causes can be prevented with simple interventions such as health education on oral rehydration, quality prenatal and emergency obstetric care, appropriate management of infections and taking appropriate precautions when prescribing potentially nephrotoxic medications. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957374/ doi: 10.1186/s12882-016-0313-8 id: cord-331109-a8e7r80d author: Ibrahim, Yassmin S. title: Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19 date: 2020-08-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has recently spread worldwide, presenting primarily in the form of pneumonia or other respiratory disease. In addition, gastrointestinal manifestations have increasingly been reported as one of the extrapulmonary features of the virus. We report two cases of SARS-CoV-2 infection complicated by paralytic ileus. The first patient was a 33-year-old man who was hospitalized with severe COVID-19 pneumonia requiring ventilator support and intensive care. He developed large bowel dilatation and perforation of the mid-transverse colon, and underwent laparotomy and colonic resection. Histopathology of the resected bowel specimen showed acute inflammation, necrosis, and hemorrhage, supporting a role for COVID-19–induced micro-thrombosis leading to perforation. The second patient was a 33-year-old man who had severe COVID-19 pneumonia, renal failure, and acute pancreatitis. His hospital course was complicated with paralytic ileus, and he improved with conservative management. Both cases were observed to have elevated liver transaminases, which is consistent with other studies. Several authors have postulated that the angiotensin-converting enzyme 2 receptors, the host receptors for COVID-19, that are present on enterocytes in both the small and large bowel might mediate viral entry and resultant inflammation. This is a potential mechanism of paralytic ileus in cases of severe COVID-19 infection. Recognizing paralytic ileus as a possible complication necessitates timely diagnosis and management. url: https://doi.org/10.4269/ajtmh.20-0894 doi: 10.4269/ajtmh.20-0894 id: cord-351776-otx5qwyu author: Ibáñez-Samaniego, Luis title: Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19 date: 2020-06-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: COVID-19 is a potentially severe disease caused by the recently described SARS-CoV-2. Whether liver fibrosis might be a relevant player in the natural history of COVID-19 is currently unknown. We aimed to evaluate the association between FIB-4 and the risk of progression to critical illness in middle-aged patients with COVID-19. METHODS: In this multicenter, retrospective study with prospective follow-up of 160 patients aged 35–65 years with COVID-19, FIB-4, clinical, and biochemical variables were collected at baseline. FIB-4 ≥2.67 defined patients with risk for advanced liver fibrosis. RESULTS: Risk for advanced fibrosis was estimated in 28.1% of patients. Patients with FIB-4 ≥2.67 more frequently required mechanical ventilation (37.8% vs 18.3%; P = .009). In multivariate analysis, FIB-4 ≥2.67 (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.30–8.92), cardiovascular risk factors (OR, 5.05; 95% CI, 1.90–13.39), previous respiratory diseases (OR, 4.54; 95% CI, 1.36–15.10), and C-reactive protein (OR, 1.01; 95% CI, 1.01–1.02) increased significantly the risk of ICU admission. Bootstrap confirmed FIB-4 as an independent risk factor. CONCLUSIONS: In middle-aged patients with COVID-19, FIB-4 may have a prognostic role. The link between liver fibrosis and the natural history of COVID-19 should be evaluated in future studies. url: https://www.ncbi.nlm.nih.gov/pubmed/32563190/ doi: 10.1093/infdis/jiaa355 id: cord-304457-8g36h1bz author: Idelsis, E.-M. title: Effect and safety of combination of interferon alpha-2b and gamma or interferon alpha-2b for negativization of SARS-CoV-2 viral RNA. Preliminary results of a randomized controlled clinical trial. date: 2020-08-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Objectives: IFN-alpha2b and IFN-gamma combination has demonstrated favorable pharmacodynamics for genes underlying antiviral activity which might be involved in the defense of the organism from a SARS-CoV-2 infection. Considering this we conducted a randomized controlled clinical trial for efficacy and safety evaluation of subcutaneous IFN-alpha2b and IFN-gamma administration in patients positive to SARS-CoV-2. Methods: We enrolled 19-82 years-old inpatients at the Military Central Hospital Luis Diaz Soto, Havana, Cuba. They were hospitalized after confirmed diagnosis for SARS-CoV-2 RNA by real-time reverse transcription polymerase chain reaction. Patients were randomly assigned in a 1:1 ratio to receive either, subcutaneous treatment with a co-lyophilized combination of 3.0 MIU IFN-alpha2b and 0.5 MIU IFN-gamma (HeberFERON, CIGB, Havana, Cuba), twice a week for two weeks, or thrice a week intramuscular injection of 3.0 MIU IFN-alpha2b (Heberon Alpha R, CIGB, Havana, Cuba). Additionally, all patients received lopinavir-ritonavir 200/50 mg every 12 h and chloroquine 250 mg every 12 h (standard of care). The primary endpoints were the time to negativization of viral RNA and the time to progression to severe COVID-19, from the start of treatment. The protocol was approved by the Ethics Committee on Clinical Investigation from the Hospital and the Center for the State Control of Medicines, Equipment and Medical Devices in Cuba. Informed consent was obtained from each participant. Results: A total of 79 patients with laboratory-confirmed SARS-CoV-2 infection, including symptomatic or asymptomatic conditions, fulfilled the inclusion criteria and underwent randomization. Thirty-three subjects were assigned to the HeberFERON group, and 33 to the Heberon Alpha R group. Sixty-three patients were analyzed for viral negativization, of them 78.6% in the HeberFERON group negativized the virus after 4 days of treatment versus 40.6% of patients in the Heberon Alpha R groups (p=0.004). Time to reach the negativization of the SARS-CoV-2 measured by RT-PCR in real time was of 3.0 and 5.0 days for the HeberFERON and Heberon Alpha R groups, respectively. A significant improvement in the reduction of time for negativization was attributable to HeberFERON (p=0.0027, Log-rank test) with a Hazard Ratio of 3.2 and 95% CI of 1.529 to 6.948, as compared to Heberon Alpha R treated group. Worsening of respiratory symptoms was detected in two (6.6%) and one (3.3%) patients in HeberFERON and IFN-alpha2b groups, respectively. None of the subjects transit to severe COVID-19 during the study or the epidemiological follow-up for 21 more days. RT-PCR on day 14 after the start of the treatment was negative to SARS-CoV-2 in 100% and 91% of patients of the combination of IFNs and IFN-alpha2b, respectively. Negativization for HeberFERON treated patients was related to a significant increase in lymphocytes counts and an also significant reduction in CRP as early as 7 days after commencing the therapeutic schedule. All the patients in both cohorts recover by day 14 and were in asymptomatic condition and laboratory parameters return to normal values by day 14 after treatment initiation. Adverse events were identified in 31.5% of patients, 28.5% in the control group, and 34.4% in the HeberFERON group, and the most frequent were headaches (17.4%). Conclusions: In a cohort of 63 hospitalized patients between 19 to 82 years-old with positive SARS-CoV-2, HeberFERON significantly negativized the virus on day 4 of treatment when comparing with IFN-alpha2b. Heberon Alpha R also showed efficacy for the treatment of the viral infection. Both treatments were safe and positively impact on the resolution of the symptoms. None of the patients developed severe COVID-19. Key words: COVID-19, treatment, drug, virus negativization, antiviral, interferon combination, SARS CoV-2. url: https://doi.org/10.1101/2020.07.29.20164251 doi: 10.1101/2020.07.29.20164251 id: cord-276834-20lcihf4 author: Idilman, Ilkay S. title: Lung and kidney perfusion deficits diagnosed by dual-energy computed tomography in patients with COVID-19-related systemic microangiopathy date: 2020-08-29 words: 4508.0 sentences: 249.0 pages: flesch: 48.0 cache: ./cache/cord-276834-20lcihf4.txt txt: ./txt/cord-276834-20lcihf4.txt summary: title: Lung and kidney perfusion deficits diagnosed by dual-energy computed tomography in patients with COVID-19-related systemic microangiopathy We evaluated lung and kidney perfusion abnormalities in patients with COVID-19 by dual-energy computed tomography (DECT) and investigated the role of perfusion abnormalities on disease severity as a sign of microvascular obstruction. CONCLUSIONS: We found that a large proportion of patients with mild-to-moderate COVID-19 had PDs in their lungs and kidneys, which may be suggestive of the presence of systemic microangiopathy with micro-thrombosis. KEY POINTS: • Pulmonary perfusion abnormalities in COVID-19 patients, associated with disease severity, can be detected by pulmonary DECT. Here, we aimed to evaluate lung and kidney perfusion abnormalities in COVID-19 patients by dual-energy computed tomography (DECT) and to investigate the role of perfusion abnormalities on disease severity as a sign of microvascular obstruction. Perfused blood volume (PBV) images and iodine maps were generated using DECT post-processing software ("Lung PBV" and "Virtual unenhanced" in syngo Dual Energy; Siemens Healthineers) on a dedicated workstation. abstract: OBJECTIVES: There is increasing evidence that thrombotic events occur in patients with coronavirus disease (COVID-19). We evaluated lung and kidney perfusion abnormalities in patients with COVID-19 by dual-energy computed tomography (DECT) and investigated the role of perfusion abnormalities on disease severity as a sign of microvascular obstruction. METHODS: Thirty-one patients with COVID-19 who underwent pulmonary DECT angiography and were suspected of having pulmonary thromboembolism were included. Pulmonary and kidney images were reviewed. Patient characteristics and laboratory findings were compared between those with and without lung perfusion deficits (PDs). RESULTS: DECT images showed PDs in eight patients (25.8%), which were not overlapping with areas of ground-glass opacity or consolidation. Among these patients, two had pulmonary thromboembolism confirmed by CT angiography. Patients with PDs had a longer hospital stay (p = 0.14), higher intensive care unit admission rates (p = 0.02), and more severe disease (p = 0.01). In the PD group, serum ferritin, aspartate aminotransferase, fibrinogen, D-dimer, C-reactive protein, and troponin levels were significantly higher, whereas albumin level was lower (p < 0.05). D-dimer levels ≥ 0.485 μg/L predicted PD with 100% specificity and 87% sensitivity. Renal iodine maps showed heterogeneous enhancement consistent with perfusion abnormalities in 13 patients (50%) with lower sodium levels (p = 0.03). CONCLUSIONS: We found that a large proportion of patients with mild-to-moderate COVID-19 had PDs in their lungs and kidneys, which may be suggestive of the presence of systemic microangiopathy with micro-thrombosis. These findings help in understanding the physiology of hypoxemia and may have implications in the management of patients with COVID-19, such as early indications of thromboprophylaxis or anticoagulants and optimizing oxygenation strategies. KEY POINTS: • Pulmonary perfusion abnormalities in COVID-19 patients, associated with disease severity, can be detected by pulmonary DECT. • A cutoff value of 0.485 μg/L for D-dimer plasma levels predicted lung perfusion deficits with 100% specificity and 87% sensitivity (AUROC, 0.957). • Perfusion abnormalities in the kidney are suggestive of a subclinical systemic microvascular obstruction in these patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00330-020-07155-3) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s00330-020-07155-3 doi: 10.1007/s00330-020-07155-3 id: cord-327125-86ocr70d author: Iehara, Tomoko title: Statement on the prevention and treatment of COVID‐19 in patients with pediatric cancer in Japan date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32568457/ doi: 10.1002/pbc.28440 id: cord-279111-jaa45kyc author: Ieven, M. title: Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries date: 2018-02-12 words: 4079.0 sentences: 208.0 pages: flesch: 46.0 cache: ./cache/cord-279111-jaa45kyc.txt txt: ./txt/cord-279111-jaa45kyc.txt summary: OBJECTIVES: To describe the role of bacteria (including bacterial resistance), viruses (including those recently described) and mixed bacterial–viral infections in adults presenting to primary care with lower respiratory tract infection (LRTI). Methods: In all, 3104 adults with LRTI were enrolled, of whom 141 (4.5%) had community-acquired pneumonia (CAP), and 2985 matched controls in a prospective study in 16 primary care networks in Europe, and followed patients up at 28e35 days. Methods: In all, 3104 adults with LRTI were enrolled, of whom 141 (4.5%) had community-acquired pneumonia (CAP), and 2985 matched controls in a prospective study in 16 primary care networks in Europe, and followed patients up at 28e35 days. Our primary objective was to describe the viral and bacterial aetiology in adult patients presenting to primary care with LRTI and in those with community-acquired pneumonia (CAP). abstract: OBJECTIVES: To describe the role of bacteria (including bacterial resistance), viruses (including those recently described) and mixed bacterial–viral infections in adults presenting to primary care with lower respiratory tract infection (LRTI). METHODS: In all, 3104 adults with LRTI were enrolled, of whom 141 (4.5%) had community-acquired pneumonia (CAP), and 2985 matched controls in a prospective study in 16 primary care networks in Europe, and followed patients up at 28–35 days. We detected Streptococcus pneumoniae and Haemophilus influenzae and assessed susceptibility, atypical bacteria and viruses. RESULTS: A potential pathogen was detected in 1844 (59%) (in 350 (11%) bacterial pathogens only, in 1190 (38%) viral pathogens only, and in 304 (10%) both bacterial and viral pathogens). The most common bacterial pathogens isolated were S. pneumoniae (5.5% overall, 9.2% in CAP patients) and H. influenzae (5.4% overall, 14.2% in CAP patients). Less than 1% of S. pneumoniae were highly resistant to penicillin and 12.6% of H. influenzae were β-lactamase positive. The most common viral pathogens detected were human rhinovirus (20.1%), influenza viruses (9.9%), and human coronavirus (7.4%). Influenza virus, human parainfluenza viruses and human respiratory syncytial virus as well as human rhinovirus, human coronavirus and human metapneumovirus were detected significantly more frequently in LRTI patients than in controls. CONCLUSIONS: A bacterial pathogen is identified in approximately one in five adult patients with LRTI in primary care, and a viral pathogen in just under half, with mixed infections in one in ten. Penicillin-resistant pneumococci and β-lactamase-producing H. influenzae are uncommon. These new findings support a restrictive approach to antibiotic prescribing for LRTI and the use of first-line, narrow-spectrum agents in primary care. url: https://api.elsevier.com/content/article/pii/S1198743X18301526 doi: 10.1016/j.cmi.2018.02.004 id: cord-298679-w0yp4u19 author: Iftimie, Simona title: Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain date: 2020-09-03 words: 3587.0 sentences: 184.0 pages: flesch: 48.0 cache: ./cache/cord-298679-w0yp4u19.txt txt: ./txt/cord-298679-w0yp4u19.txt summary: Logistic regression analyses showed that fever, pneumonia, acute respiratory distress syndrome, diabetes mellitus and cancer were the variables that showed independent and statistically significant associations with mortality. This is one of the first studies to describe the factors associated with mortality in patients infected with SARS-CoV-2 in Spain, and one of the few in the Mediterranean area. The objective of the present study has been to characterize our patients'' epidemiology and to identify the risk factors associated with mortality for this disease in our geographical area. Logistic regression analyses showed that the presence of fever, pneumonia, acute respiratory distress syndrome, type 2 diabetes mellitus and cancer were the only variables that showed an independent and statistically significant association with mortality when they were adjusted for differences in age, gender, smoking status and alcohol intake (Tables 2 and 3) . Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China abstract: Spain is one of the countries that has suffered the most from the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the strain that causes coronavirus disease 2019 (COVID-19). However, there is a lack of information on the characteristics of this disease in the Spanish population. The objective of this study has been to characterize our patients from an epidemiological point of view and to identify the risk factors associated with mortality in our geographical area. We performed a prospective, longitudinal study on 188 hospitalized cases of SARS-Cov-2 infection in Hospital Universitari de Sant Joan, in Reus, Spain, admitted between 15(th) March 2020 and 30(th) April 2020. We recorded demographic data, signs and symptoms and comorbidities. We also calculated the Charlson and McCabe indices. A total of 43 deaths occurred during the study period. Deceased patients were older than the survivors (77.7 ± 13.1 vs. 62.8 ± 18.4 years; p < 0.001). Logistic regression analyses showed that fever, pneumonia, acute respiratory distress syndrome, diabetes mellitus and cancer were the variables that showed independent and statistically significant associations with mortality. The Charlson index was more efficient than the McCabe index in discriminating between deceased and survivors. This is one of the first studies to describe the factors associated with mortality in patients infected with SARS-CoV-2 in Spain, and one of the few in the Mediterranean area. We identified the main factors independently associated with mortality in our population. Further studies are needed to complete and confirm our findings. url: https://doi.org/10.1371/journal.pone.0234452 doi: 10.1371/journal.pone.0234452 id: cord-313628-6610z7xk author: Igbinosa, Irogue title: Use of Remdesivir for Pregnant Patients with Severe Novel 2019 Coronavirus Disease date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0002937820308292?v=s5 doi: 10.1016/j.ajog.2020.08.001 id: cord-339471-1510mzmy author: Ikizler, T. Alp title: COVID-19 in Dialysis Patients: Adding a Few More Pieces to the Puzzle date: 2020-05-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The clinical presentation and mortality rate in maintenance hemodialysis (MHD) patients with COVID-19 are not well established. Recent data from Italy and Spain suggest that these patients present with wide range of symptoms, with a significant portion being asymptomatic. There is prolonged positivity of pharyngeal swabs in MHD patients. The mortality rates are very high, reaching almost 30%. These data highlight the importance of diligent oversight and care of MHD patients during COVID-19 pandemic. url: https://www.sciencedirect.com/science/article/pii/S008525382030510X?v=s5 doi: 10.1016/j.kint.2020.04.032 id: cord-291244-o4isx15k author: Ikuyama, Yuichi title: Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date: 2020-05-31 words: 2382.0 sentences: 133.0 pages: flesch: 44.0 cache: ./cache/cord-291244-o4isx15k.txt txt: ./txt/cord-291244-o4isx15k.txt summary: Herein, we report a case of critical COVID-19 pneumonia treated with extracorporeal membrane oxygenation from symptom onset day 19 (SOD#19) to SOD#30. Here, we report the clinical course of a patient with a severe case of COVID-19 complicated with acute respiratory distress syndrome (ARDS). We report the patient''s response to intensive care, including invasive ventilation in the early stage of the illness and extracorporeal membrane oxygenation (ECMO) with antiviral, immunomodulatory, and glucocorticoid therapies as the illness progressed. In this case, ECMO showed great effectiveness 13 in treating the patient''s rapidly deteriorating respiratory status due to pneumonia. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study • A critical case of 76-year-old female with COVID-19 pneumonia.• No significant clinical benefits of lopinavir-ritonavir and peramivir treatment.• The pneumonia rapidly progressed to acute respiratory distress syndrome.• Extracorporeal membrane oxygenation from illness day 21 to 31 lead to recovery. abstract: A public health emergency of current international concern is the outbreak of a severe respiratory illness, that is, coronavirus disease (COVID-19). The disease initially started in Wuhan, China, and it rapidly spread to most regions of the world. Herein, we report a case of critical COVID-19 pneumonia treated with extracorporeal membrane oxygenation from symptom onset day 19 (SOD#19) to SOD#30. We describe the patient's clinical course, from mild symptoms at the time of illness onset to symptoms of severe pneumonia as the illness progressed. We provide important information regarding our clinical experience for further understanding of management discrepancies, as treatment with extracorporeal membrane oxygenation or pharmacotherapy (e.g., antivirals, immunomodulators, and glucocorticoids) is often dependent on the severity of symptoms. url: https://www.sciencedirect.com/science/article/pii/S2213007120301714?v=s5 doi: 10.1016/j.rmcr.2020.101113 id: cord-309370-g8d3w7it author: Insausti-García, Alfredo title: Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state date: 2020-07-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading to venous insufficiency and compression of the central retina vein. The disease affects healthy young adults and commonly has a benign course, however, if complications such as macular edema or ischemia appears, treatment should be instituted immediately to avoid poor prognosis. CASE REPORT: A 40-year old white male patient consulted for a slight decrease in the sensitivity of the visual field in his left eye (OS). Visual acuities (VA) were 20/20 in both eyes. OS fundus examination showed dilated and tortuous retinal vessels, disc edema, and retinal hemorrhages. The patient was diagnosed with papillophlebitis. OS VA decreased to 20/200 due to macular edema, and he was treated with a intravitreal dexamethasone implant. An exhaustive and interdisciplinary exploration process was performed, identifying a recent disease and recovery of Covid-19 as the only factor of inflammation and coagulation alteration. Other systemic diseases were excluded. We also describe a rapid decrease in disc and macular edema after intravitreal dexametasone injection, which could support the inflammatory hypothesis. CONCLUSION: The importance of this case lies in the possible association of papillophlebitis with the new Covid-19 disease. We believe that the inflammatory reaction and the coagulation alteration present in our patient due to Sars-Cov2 coronavirus may have acted as risk factors for the development of papillophlebitis. url: https://doi.org/10.1177/1120672120947591 doi: 10.1177/1120672120947591 id: cord-006302-pnnkfid0 author: Ioakeimidou, A. title: Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction date: 2017-04-28 words: 2944.0 sentences: 160.0 pages: flesch: 51.0 cache: ./cache/cord-006302-pnnkfid0.txt txt: ./txt/cord-006302-pnnkfid0.txt summary: We studied the follow-up changes of circulating vasoactive peptides and cytokines until the improvement or the worsening of a patient and progression into specific organ dysfunctions. In a prospective study, concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), endocan and angiopoietin-2 (Ang-2) were measured in serum by an enzyme immunoassay in 175 patients at baseline; this was repeated within 24 h upon progression into new organ dysfunction (n = 141) or improvement (n = 34). Our aims were to monitor the changes of circulating levels of pro-inflammatory and antiinflammatory cytokines and of vasoactive peptides of critically ill patients at well-defined time-points of the clinical course and to understand how these changes mediate progression to organ dysfunction in an individualized way. When pair-wise comparisons between baseline and follow-up measurements were done within the subgroups of patients developing new organ dysfunctions, it was found that the only parameters significantly changing were endocan and Ang-2. abstract: How circulating inflammatory mediators change upon sepsis progression has not been studied. We studied the follow-up changes of circulating vasoactive peptides and cytokines until the improvement or the worsening of a patient and progression into specific organ dysfunctions. In a prospective study, concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), endocan and angiopoietin-2 (Ang-2) were measured in serum by an enzyme immunoassay in 175 patients at baseline; this was repeated within 24 h upon progression into new organ dysfunction (n = 141) or improvement (n = 34). Endocan and Ang-2 were the only parameters that were significantly increased among patients who worsened. Any increase of endocan was associated with worsening with odds ratio 16.65 (p < 0.0001). This increase was independently associated with progression into acute respiratory distress syndrome (ARDS) as shown after logistic regression analysis (odds ratio 2.91, p: 0.002). Changes of circulating cytokines do not mediate worsening of the critically ill patients. Instead endocan and Ang2 are increased and this may be interpreted as a key-playing role in the pathogenesis of ARDS and septic shock. Any increase of endocan is a surrogate of worsening of the clinical course. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101577/ doi: 10.1007/s10096-017-2988-6 id: cord-343973-n5ogyxz7 author: Ip, Andrew title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Hydroxychloroquine has been touted as a potential COVID-19 treatment. Tocilizumab, an inhibitor of IL-6, has also been proposed as a treatment of critically ill patients. In this retrospective observational cohort study drawn from electronic health records we sought to describe the association between mortality and hydroxychloroquine or tocilizumab therapy among hospitalized COVID-19 patients. Patients were hospitalized at a 13-hospital network spanning New Jersey USA between March 1, 2020 and April 22, 2020 with positive polymerase chain reaction results for SARS-CoV-2. Follow up was through May 5, 2020. Among 2512 hospitalized patients with COVID-19 there have been 547 deaths (22%), 1539 (61%) discharges and 426 (17%) remain hospitalized. 1914 (76%) received at least one dose of hydroxychloroquine and 1473 (59%) received hydroxychloroquine with azithromycin. After adjusting for imbalances via propensity modeling, compared to receiving neither drug, there were no significant differences in associated mortality for patients receiving any hydroxychloroquine during the hospitalization (HR, 0.99 [95% CI, 0.80–1.22]), hydroxychloroquine alone (HR, 1.02 [95% CI, 0.83–1.27]), or hydroxychloroquine with azithromycin (HR, 0.98 [95% CI, 0.75–1.28]). The 30-day unadjusted mortality for patients receiving hydroxychloroquine alone, azithromycin alone, the combination or neither drug was 25%, 20%, 18%, and 20%, respectively. Among 547 evaluable ICU patients, including 134 receiving tocilizumab in the ICU, an exploratory analysis found a trend towards an improved survival association with tocilizumab treatment (adjusted HR, 0.76 [95% CI, 0.57–1.00]), with 30 day unadjusted mortality with and without tocilizumab of 46% versus 56%. This observational cohort study suggests hydroxychloroquine, either alone or in combination with azithromycin, was not associated with a survival benefit among hospitalized COVID-19 patients. Tocilizumab demonstrated a trend association towards reduced mortality among ICU patients. Our findings are limited to hospitalized patients and must be interpreted with caution while awaiting results of randomized trials. Trial Registration: Clinicaltrials.gov Identifier: NCT04347993 url: https://doi.org/10.1371/journal.pone.0237693 doi: 10.1371/journal.pone.0237693 id: cord-294064-vdpak3fm author: Iqbal, Muhammad Rafaih title: Single centre concept of ‘cold site’ elective surgery during the peak of COVID-19 pandemic: A cohort study date: 2020-10-06 words: 3028.0 sentences: 190.0 pages: flesch: 59.0 cache: ./cache/cord-294064-vdpak3fm.txt txt: ./txt/cord-294064-vdpak3fm.txt summary: title: Single centre concept of ''cold site'' elective surgery during the peak of COVID-19 pandemic: A cohort study Our hospital utilised local private hospital as a dedicated cold site (CS) for urgent elective surgery during the peak of the COVID-19 pandemic. CONCLUSION: Urgent elective surgery is safe and feasible during the COVID-19 pandemic if a dedicated cold site is available. A mortality of 19% has been reported in a recent study on 278 patients undergoing elective surgery who were diagnosed with COVID-19 peri-operatively (6) . This was a retrospective review of a prospectively maintained database of consecutive patients undergoing urgent elective surgery at the dedicated CS during the COVID-19 pandemic. J o u r n a l P r e -p r o o f J o u r n a l P r e -p r o o f ¨ This study reports findings of a dedicated cold site elective surgery during the peak of COVID-19 pandemic. abstract: OBJECTIVE: The COVID-19 pandemic caused a major strain on healthcare systems across the globe. As these systems got overwhelmed with the emergency care of the infected patients, widespread cancellations of elective surgery occurred. Our hospital utilised local private hospital as a dedicated cold site (CS) for urgent elective surgery during the peak of the COVID-19 pandemic. We aim to analyse the outcomes at this dedicated cold site. METHOD: A retrospective review of a prospectively maintained database of all the cases operated at the CS during a 2-month period (30 March 2020 to 29 May 2020) was carried out. The primary outcome was 30-day COVID-19 related mortality. The secondary outcomes were 30-day non-COVID-19 related mortality, complications, readmission and development of COVID-19 symptoms. RESULTS: A total of 153 patients were operated on at the CS over the study period with a median age of 57 years (Interquartile range, IQR 47–70). 62% were females and 82% had a Body Mass Index (BMI) less than 30.73% of the operations were performed for cancer. 59% of the surgeries were graded as intermediate and 26% as major or complex. There was no mortality at 30 days from COVID-19 or non COVID-19 causes. There was only 1 (0.65%) readmission. 7 patients (4.57%) developed complications. 1 (0.65%) patient was diagnosed with COVID-19 in the postoperative period while 3 had COVID-19 symptoms but were tested negative. CONCLUSION: Urgent elective surgery is safe and feasible during the COVID-19 pandemic if a dedicated cold site is available. url: https://www.ncbi.nlm.nih.gov/pubmed/33042534/ doi: 10.1016/j.amsu.2020.09.047 id: cord-291024-9g4om4sf author: Isakbaeva, Elmira T. title: SARS-associated Coronavirus Transmission, United States date: 2004-02-17 words: 3669.0 sentences: 160.0 pages: flesch: 53.0 cache: ./cache/cord-291024-9g4om4sf.txt txt: ./txt/cord-291024-9g4om4sf.txt summary: To better assess the risk for transmission of the severe acute respiratory syndrome–associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. To that end, we obtained serial biologic specimens and clinical and exposure data for 5 to 10 weeks after onset of illness from seven laboratory-confirmed U.S. SARS patients and their household contacts. We detected SARS-CoV in fecal and respiratory specimens and found that SARS case-patients may have high concentrations of virus in stools during the 2nd week of illness and continue to shed the virus in feces until at least 26 days after onset of symptoms. All upper respiratory specimens in the first 2 weeks after onset were negative for SARS-CoV by RT-PCR; this finding differs from a report in Hong Kong, where viral RNA was detected in nasopharyngeal aspirates of 68% of case-patients at day 14 (21) . abstract: To better assess the risk for transmission of the severe acute respiratory syndrome–associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Laboratory diagnosis of SARS-CoV infection is difficult; thus, sputum and stool specimens should be included in the diagnostic work-up for SARS-CoV infection. url: https://www.ncbi.nlm.nih.gov/pubmed/15030687/ doi: 10.3201/eid1002.030734 id: cord-253886-4b3i30hi author: Isakov, Alexander title: Transport and Management of Patients With Confirmed or Suspected Ebola Virus Disease date: 2015-05-21 words: 3694.0 sentences: 173.0 pages: flesch: 41.0 cache: ./cache/cord-253886-4b3i30hi.txt txt: ./txt/cord-253886-4b3i30hi.txt summary: The foundation of safe care for patients with confirmed or suspected Ebola virus disease is effective infection control practice, which requires implementation of appropriate administrative policies, work practices, and environmental controls, accompanied by focused education, training, and supervision. However, the transport of the first patient with confirmed Ebola virus disease to the United States (Atlanta, GA), the transport of the first US-diagnosed Ebola virus disease case (Dallas, TX), and the first transmission of Ebola virus disease to health care workers in the United States understandably raised anxiety in the EMS community about the appropriate education and training, policies, and procedures, as well as supervision required, to be best prepared for transporting patients with serious communicable disease in the United States. The objectives of these hospital and out-of-hospital collaborations were to close education, training, and practice gaps to best facilitate the care for patients with serious communicable disease while ensuring the safety of the medics and the general public through meticulous implementation of infection control practices as recommended by CDC. abstract: The foundation of safe care for patients with confirmed or suspected Ebola virus disease is effective infection control practice, which requires implementation of appropriate administrative policies, work practices, and environmental controls, accompanied by focused education, training, and supervision. In 2002, Emory University partnered with the Centers for Disease Control and Prevention to develop a capability for the evaluation and management of individuals with serious communicable disease. In 2005, the University of Nebraska developed a similar isolation capability. In each case, the hospitals partnered with emergency medical services (EMS) professionals to ensure safe out-of-hospital transport and management of their patients. The objectives of these hospital and out-of-hospital collaborations were to close education, training, and practice gaps to best facilitate the care for patients with serious communicable disease while ensuring the safety of the medics and the general public through meticulous implementation of infection control practices as recommended by Centers for Disease Control and Prevention. The description of practices implemented by EMS teams in these communities for the transport of patients with confirmed Ebola virus disease is shared so that others might more readily implement these practices, policies, and procedures as applicable to their mission requirements and system design. Transport of patients with relevant travel history and development of illness (persons under investigation) is also included. url: https://www.ncbi.nlm.nih.gov/pubmed/26003000/ doi: 10.1016/j.annemergmed.2015.04.008 id: cord-030962-2xem8inu author: Isea de la Viña, Jesus title: Lung cancer patients on the waiting list in the midst of the COVID-19 crisis: what do we do now?() date: 2020-08-28 words: 911.0 sentences: 54.0 pages: flesch: 55.0 cache: ./cache/cord-030962-2xem8inu.txt txt: ./txt/cord-030962-2xem8inu.txt summary: Reference centers, which have a greater number of cases, have had to vacate wards and intensive care units to make room for patients infected with the coronavirus, so the impossibility of transferring surgical patients from regional to tertiary hospitals to receive specialized care and the waiting list delays caused by the suspension of scheduled operations will soon have an impact on patients with lung cancer (LC) not infected by this virus. The American College of Surgeons (ACS), 1 in their recently published guidelines on the management of patients scheduled for thoracic surgery, categorize the general status of hospitals into 3 phases according to the number of COVID-19 patients admitted: phase 1 -preparation; phase 2 -urgent setting; and phase 3 -ଝ Please cite this article as: Isea de la Viña J, Mayol J, Ortega AL, Alcázar Navarrete AN. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453218/ doi: 10.1016/j.arbr.2020.05.003 id: cord-338517-1mxcssjj author: Ishay, Yuval title: Antibody response to SARS‐Co‐V‐2, diagnostic and therapeutic implications date: 2020-08-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The immune response against SARS‐CoV‐2 is comprised of both cellular and humoral arms. While current diagnostic methods are mainly based on PCR, they suffer from insensitivity. Therefore, antibody‐based serological tests are being developed to achieve higher sensitivity and specificity. Current efforts in treating SARS‐CoV‐2 infection include blocking of viral entry into the host cells, prohibiting viral replication and survival in the host cells, or reducing the exaggerated host immune response. Administration of convalescent plasma containing anti‐viral antibodies was proposed to improve the outcome in severe cases. In this paper, we review some of the aspects associated with the development of antibodies against SARS‐CoV‐2 and their potential use for improved diagnosis and therapy. url: https://doi.org/10.1002/hep4.1600 doi: 10.1002/hep4.1600 id: cord-327611-g2ssh0fk author: Ishkanian, Amy title: Clinical Conundrum: Dysphagia in a Patient with COVID-19 and Progressive Muscle Weakness date: 2020-10-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33130952/ doi: 10.1007/s00455-020-10205-z id: cord-345655-fb4vv4my author: Islam, M. Z. title: Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28th day of the disease course: a retrospective cohort study in Bangladesh date: 2020-10-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Diverse risk factors intercede the outcomes of coronavirus disease 2019 (COVID-19). We conducted this retrospective cohort study with a cohort of 1016 COVID-19 patients diagnosed in May 2020 to identify the risk factors associated with morbidity and mortality outcomes. Data were collected by telephone-interview and reviewing records using a questionnaire and checklist. The study identified morbidity and mortality risk factors on the 28th day of the disease course. The majority of the patients were male (64.1%) and belonged to the age group 25–39 years (39.4%). Urban patients were higher in proportion than rural (69.3% vs. 30.7%). Major comorbidities included 35.0% diabetes mellitus (DM), 28.4% hypertension (HTN), 16.6% chronic obstructive pulmonary disease (COPD), and 7.8% coronary heart disease (CHD). The morbidity rate (not-cured) was 6.0%, and the mortality rate (non-survivor) was 2.5%. Morbidity risk factors included elderly (AOR = 2.56, 95% CI = 1.31–4.99), having comorbidity (AOR = 1.43, 95% CI = 0.83–2.47), and smokeless tobacco use (AOR = 2.17, 95% CI = 0.84–5.61). The morbidity risk was higher with COPD (RR = 2.68), chronic kidney disease (CKD) (RR = 3.33) and chronic liver disease (CLD) (RR = 3.99). Mortality risk factors included elderly (AOR = 7.56, 95% CI = 3.19–17.92), having comorbidity (AOR = 5.27, 95% CI = 1.88–14.79) and SLT use (AOR = 1.93, 95% CI = 0.50–7.46). The mortality risk was higher with COPD (RR = 7.30), DM (RR = 2.63), CHD (RR = 4.65), HTN (RR = 3.38), CKD (RR = 9.03), CLD (RR = 10.52) and malignant diseases (RR = 9.73). We must espouse programme interventions considering the morbidity and mortality risk factors to condense the aggressive outcomes of COVID-19. url: https://doi.org/10.1017/s0950268820002630 doi: 10.1017/s0950268820002630 id: cord-301391-5dvf1mi0 author: Islam, Md. Milon title: Breathing Aid Devices to Support Novel Coronavirus (COVID-19)Infected Patients date: 2020-08-19 words: 4402.0 sentences: 266.0 pages: flesch: 53.0 cache: ./cache/cord-301391-5dvf1mi0.txt txt: ./txt/cord-301391-5dvf1mi0.txt summary: It is a matter of hope that the recent deployment of small-scale technologies like 3D printer, microcontroller, ventilator, Continuous Positive Airway Pressure (CPAP) are mostly used to resolve the problem associated with medical equipment''s for breathing. We described the most recent developed breathing aid devices such as oxygen therapy devices, ventilator, and CPAP throughout the review. The review described breathing aid devices like oxygen therapy devices, ventilators, and CPAP devices. Breathing aid devices are used to support the patients who have acute respiration problem due to pneumonia associated diseases like COVID-19, asthma, and dry coughing. The key feature of this study is that without any respiration tubes, the proposed device can provide necessary ventilation to the patient''s lungs with the blower unit. A lowcost, microcontroller controlled electro-mechanical device is developed in [61] for the respiratory support of COVID-19 infected patients. [66] proposed a multi-powered CPAP device for respiratory support for the patients having a breathing problem. abstract: Novel coronavirus (COVID-19), an ongoing pandemic, is threatening the whole population all over the world including the nations having high or low resource health infrastructure. The number of infection as well as death cases are increasing day by day, and outperforming all the records of previously found infectious diseases. This pandemic is imposing specific pressures on the medical system almost the whole globe. The respiration problem is the main complication that a COVID-19 infected patient faced generally. It is a matter of hope that the recent deployment of small-scale technologies like 3D printer, microcontroller, ventilator, Continuous Positive Airway Pressure (CPAP) are mostly used to resolve the problem associated with medical equipment’s for breathing. This paper aims to overview the existing technologies which are frequently used to support the infected patients for respiration. We described the most recent developed breathing aid devices such as oxygen therapy devices, ventilator, and CPAP throughout the review. A comparative analysis among the developed devices with necessary challenges and possible future directions are also outlined for the proper selection of affordable technologies. It is expected that this paper would be of great help to the experts who would like to contribute in this area. url: https://www.ncbi.nlm.nih.gov/pubmed/33063053/ doi: 10.1007/s42979-020-00300-1 id: cord-342303-ddulfe06 author: Ismael, Julia title: Multidisciplinary approach to COVID-19 and cancer: consensus from scientific societies in Argentina date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The world is living through an outbreak of an acute respiratory syndrome caused by a new betacoronavirus known as coronavirus 2 (SARS CoV-2), which has been declared an international public health emergency by the World Health Organisation. Cancer patients are a very special population in this setting since they are more susceptible to viral infections than the general population. Several recommendations have been made on this issue, most of them based on expert opinion and institutional experience. It is essential to gather the evidence available for decision making. OBJECTIVE: To review the evidence available in order to create a multi-institutional position from the perspective of scientific societies in Argentina involved in the management of cancer patients. METHODOLOGY: The review included two phases: 1) search and systematic revision of the medical literature; 2) consensus and revision of the document drafted by national scientific societies involved in the management and care of cancer patients using the modified Delphi method. The final results were presented at a videoconference with all the participants. Also, additional comment and recommendations were discussed. The final document was revised and approved for publication by the members of the panel. RESULTS: The consensus panel included 18 representatives from scientific societies from Argentina who assessed the evidence and then made recommendations for the management of cancer patients in our country. International guidelines (CDC; ASCO, NCCN and ESMO) were considered as a background for analysis, as well as institutional guidelines and an open ad hoc survey administered to 114 healthcare professionals from the scientific societies involved in this study. The recommendations are grouped as follows: 1) general care interventions—training of the personnel, cleaning and disinfection of the hospital premises and patient scheduling; 2) treatment decisions—patient care, surgeries, immunosuppressive therapy, radiotherapy and screening; 3) ethical considerations—optimisation of resources, end-of-life care for critically-ill patients; 4) management of hospitalised patients; and 5) wellbeing of the healthcare team. The general recommendation arising from the study is that the management of cancer patients must adapt to the exceptional pandemic status quo without disregarding treatment or cure options. Moreover, healthcare professional accompaniment of all patients should not be neglected. All healthcare professionals must make a significant joint effort to create multidisciplinary teams to discuss the most appropriate measures for each particular situation. CONCLUSIONS: The scientific evidence available on this topic worldwide is in progress. This together with the epidemiologically shifting scenario poses unprecedented challenges in the management of cancer amidst this global pandemic. Furthermore, the key role of the healthcare structural organisation appears evident, such as the drafting of clear guidelines for all the stakeholders, adaptability to constant change and an interdisciplinary shared vision through consensus to provide adequate care to our cancer patients in the light of uncertainty and fast-paced change. url: https://doi.org/10.3332/ecancer.2020.1044 doi: 10.3332/ecancer.2020.1044 id: cord-268617-1t7yaoct author: Ismaili, Nabil title: COVID-19 and Gynecological Cancers: A Summary of International Recommendations date: 2020-08-31 words: 3974.0 sentences: 216.0 pages: flesch: 42.0 cache: ./cache/cord-268617-1t7yaoct.txt txt: ./txt/cord-268617-1t7yaoct.txt summary: Given this epidemiological context, the establishment of guidelines for patients with gynecological cancers, requiring multidisciplinary management during the global COVID-19 pandemic, is crucial to limit their infection while maintaining their chances for a cure. The surgical prioritization is determined according to: The highest priority should be given to the surgical treatment of high-risk cancers, especially those candidates for minimally invasive surgery (such as robotic surgery) and short hospital stay, in addition to potentially curative procedures for early-stage cancers. In stage II endometrial cancer, proceed with radical surgery and consider adjuvant therapy for patients with high-risk factors (same as stage I). For patients with advanced stage (stages III/IV) high-grade epithelial (serous or endometrioid) ovarian cancer, the standard treatment is based on primary debulking surgery and adjuvant chemotherapy (protocol based on the result of the surgery). abstract: Morocco and the rest of the world are experiencing a pandemic of a new coronavirus known as COVID-19 or SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). On August 24, 2020, the spread of the virus in Morocco had caused more than 52,000 cases and 880 deaths. Cancer patients are more susceptible to develop an infection than people without cancer because of their immunosuppression caused by the disease and treatments (surgery and chemotherapy). Therefore, these patients are at higher risk of infection with COVID-19 and a much higher risk of developing more serious forms. Given this epidemiological context, the establishment of guidelines for patients with gynecological cancers, requiring multidisciplinary management during the global COVID-19 pandemic, is crucial to limit their infection while maintaining their chances for a cure. In this paper, we summarize the international COVID-19 recommendations on the prioritization of surgical cases, the perioperative protective measures, the precautions to be taken in the brachytherapy unit, the COVID-19 screening, and finally the therapeutic indications of gynecological cancers by tumor location. url: https://www.ncbi.nlm.nih.gov/pubmed/32904733/ doi: 10.1007/s42399-020-00475-x id: cord-323913-v32c2vda author: Istúriz, Raul E. title: Global Distribution of Infectious Diseases Requiring Intensive Care date: 2006-07-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This article describes infectious diseases that are of special importance to intensivists. The emphasis on epidemiology notwithstanding, it also addresses clinical, diagnostic, and treatment issues related to each infection described. The discussion avoids terrorism-related aspects of these infections, because they were very well covered in the October 2005 issue of the Critical Care Clinics. url: https://www.ncbi.nlm.nih.gov/pubmed/16893734/ doi: 10.1016/j.ccc.2006.03.004 id: cord-301592-n5ns3m34 author: Ivaska, Lauri title: Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection date: 2017-01-07 words: 4142.0 sentences: 249.0 pages: flesch: 47.0 cache: ./cache/cord-301592-n5ns3m34.txt txt: ./txt/cord-301592-n5ns3m34.txt summary: We aimed to document the viral and bacterial aetiology of pharyngitis and to assess the pathogenic role of viruses by determining the myxovirus resistance protein A (MxA) in the blood as a marker of interferon response. We aimed to document the viral and bacterial aetiology of pharyngitis and to assess the pathogenic role of viruses by determining the myxovirus resistance protein A (MxA) in the blood as a marker of interferon response. Methods: In this prospective observational study, throat swabs and blood samples were collected from children (age 1e16 years) presenting to the emergency department with febrile pharyngitis. Methods: In this prospective observational study, throat swabs and blood samples were collected from children (age 1e16 years) presenting to the emergency department with febrile pharyngitis. 23e25 The aim of this study was to document the microbial causes of acute pharyngitis in children and adolescents in an outpatient setting and to evaluate the causative role of viruses by determining myxovirus resistance protein A (MxA) and other biomarker levels. abstract: OBJECTIVES: Besides group A streptococcus (GAS), microbial causes of pharyngitis in children are not well known. We aimed to document the viral and bacterial aetiology of pharyngitis and to assess the pathogenic role of viruses by determining the myxovirus resistance protein A (MxA) in the blood as a marker of interferon response. METHODS: In this prospective observational study, throat swabs and blood samples were collected from children (age 1–16 years) presenting to the emergency department with febrile pharyngitis. Microbial cause was sought by bacterial culture, polymerase chain reaction, and serology. Blood MxA level was determined. RESULTS: A potential pathogen was detected in 88% of 83 patients: GAS alone in 10%, GAS and viruses in 13%, group C or G streptococci alone in 2% and together with viruses in 3%, and viruses alone in 59% of cases. Enteroviruses, rhinoviruses, and adenoviruses were the most frequently detected viruses. Blood MxA levels were higher in children with viral (880 [245–1250] μg/L; median [IQR]) or concomitant GAS-viral (340 [150–710] μg/L) than in those with sole GAS (105 [80–160] μg/L) infections. CONCLUSIONS: Detection of respiratory viruses simultaneously with elevated blood MxA levels supports the causative role of viruses in the majority of children with pharyngitis. url: https://doi.org/10.1016/j.jinf.2017.01.002 doi: 10.1016/j.jinf.2017.01.002 id: cord-345092-1ztfcpsb author: Iwasaki, Masae title: Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications date: 2020-10-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein of SARS-CoV-2 binds with angiotensin-converting enzyme 2 (ACE2) as a functional “receptor” and then enters into host cells to replicate and damage host cells and organs. ACE2 plays a pivotal role in the inflammation, and its downregulation may aggravate COVID-19 via the renin-angiotensin system, including by promoting pathological changes in lung injury and involving inflammatory responses. Severe patients of COVID-19 often develop acute respiratory distress syndrome and multiple organ dysfunction/failure with high mortality that may be closely related to the hyper-proinflammatory status called the “cytokine storm.” Massive cytokines including interleukin-6, nuclear factor kappa B (NFκB), and tumor necrosis factor alpha (TNFα) released from SARS-CoV-2-infected macrophages and monocytes lead inflammation-derived injurious cascades causing multi-organ injury/failure. This review summarizes the current evidence and understanding of the underlying mechanisms of SARS-CoV-2, ACE2 and inflammation co-mediated multi-organ injury or failure in COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33029758/ doi: 10.1007/s10753-020-01337-3 id: cord-004186-m817oudw author: Iwata, Shihoko title: Anesthetic management of a patient with a continuous-flow left ventricular assist device for video-assisted thoracoscopic surgery: a case report date: 2020-01-20 words: 3769.0 sentences: 196.0 pages: flesch: 45.0 cache: ./cache/cord-004186-m817oudw.txt txt: ./txt/cord-004186-m817oudw.txt summary: title: Anesthetic management of a patient with a continuous-flow left ventricular assist device for video-assisted thoracoscopic surgery: a case report Here, we present the anesthetic management of a patient with a continuous-flow LVAD who underwent video-assisted thoracic surgery (VATS). In the present case, when the patient was set in a lateral decubitus position and progressive hypoxia was observed during OLV, transesophageal echocardiography demonstrated a dilated right ventricle and a temporally flattened interventricular septum, and the central venous pressure increased to approximately 20 mmHg. Because we anticipated deterioration of right heart function, dobutamine and milrinone were administered and/or respirator settings were changed to decrease PVR for maintaining LVAD performance. CONCLUSIONS: The anesthetic management of a patient with LVAD during VATS is challenging because the possible hemodynamic changes induced by hypoxia associated with OLV affect LVAD performance and right heart function. Anesthetic management of patients with continuous-flow left ventricular assist devices undergoing noncardiac surgery: an update for anesthesiologists abstract: BACKGROUND: As patients with left ventricular assist device (LVAD) have long expected survival, the incidence of noncardiac surgery in this patient population is increasing. Here, we present the anesthetic management of a patient with a continuous-flow LVAD who underwent video-assisted thoracic surgery (VATS). CASE PRESENTATION: A 37-year-old man with LVAD was scheduled to undergo VATS because of repeated spontaneous pneumothorax. Generally, patients with these devices have marginal right heart function; therefore, it is important to avoid factors that worsen pulmonary vascular resistance (PVR). However, VATS requires one-lung ventilation (OLV) and it tends to cause increase in PVR, leading to right heart failure. In the present case, when the patient was set in a lateral decubitus position and progressive hypoxia was observed during OLV, transesophageal echocardiography demonstrated a dilated right ventricle and a temporally flattened interventricular septum, and the central venous pressure increased to approximately 20 mmHg. Because we anticipated deterioration of right heart function, dobutamine and milrinone were administered and/or respirator settings were changed to decrease PVR for maintaining LVAD performance. Finally, resection of a bulla was completed, and the patient was discharged in stable condition on postoperative day 37. CONCLUSIONS: The anesthetic management of a patient with LVAD during VATS is challenging because the possible hemodynamic changes induced by hypoxia associated with OLV affect LVAD performance and right heart function. In our experience, VATS that requires OLV will be well tolerated in a patient with LVAD with preserved right heart function, and a multidisciplinary approach to maintain right heart function will be needed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972011/ doi: 10.1186/s12871-020-0933-1 id: cord-306154-nm0g79ih author: JEGANATHAN, Sumithra title: Adherence and Acceptability of Telehealth Appointments for High Risk Obstetrical Patients During the COVID-19 Pandemic date: 2020-09-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background Telehealth has been successfully implemented for the delivery of obstetrical care. However, little is known regarding the attitudes and acceptability of patients and providers in high risk obstetrics and if implementation improves access to care in non-rural settings. Objective The study aims to: 1) Describe patient and provider attitudes toward telehealth for delivery of high risk obstetrical care in a large health care system with both urban and suburban settings. 2) Determine if implementation of a telehealth model improves patient adherence to scheduled appointments in this patient population. Study DesignTwo self-administered surveys were designed. The first survey was sent to all high-risk obstetrical patients who received a telehealth visit between March 1, 2020 and May 30, 2020. The second survey was designed for providers who participated in these visits. We also compared the attended, cancelled and no show visit rates before (March 1-May 30, 2019) and after (March 1-May 30, 2020) telehealth implementation, as well as telehealth versus in person visits in 2020. We reviewed scheduled high-risk prenatal care appointments, diabetes education sessions, and genetic counseling and Maternal- Fetal Medicine consultations. Results A total of 91 patient surveys and 33 provider surveys were analyzed. Overall, 86.9% of patients were satisfied with the care they received and 78.3% would recommend telehealth visits to others. 87.8% of providers reported having a positive experience using telehealth, and 90.9% believed that telehealth improved patients’ access to care. When comparing patient and provider preference regarding future obstetrical care after experiencing telehealth, 73.8% of patients desired a combination of in person and telehealth visits during their pregnancy. However, a significantly higher rate of providers preferred in-person visits (56% vs 23% respectively). When comparing visits between 2019 and 2020, there was a significantly lower rate of no-show appointments, patient-cancelled appointments, and patient same-day cancellations with the implementation of telehealth. There was also a significantly lower rate of patient-cancelled appointments, and patient same-day cancellations with those receiving telehealth visits compared to in person visits in 2020. Conclusion Implementation of telehealth in high risk obstetrics has the potential to improve access to high risk obstetrical care, by reducing the rate of missed appointments. Both patients and providers surveyed expressed a high rate of satisfaction with telehealth visits and a desire to integrate telehealth into the traditional model of high risk obstetrical care. url: https://doi.org/10.1016/j.ajogmf.2020.100233 doi: 10.1016/j.ajogmf.2020.100233 id: cord-264889-1vsvcza2 author: Jackson, Craig T. title: The Ties That Bind: A Coronavirus Disease Journey date: 2020-10-16 words: 1129.0 sentences: 65.0 pages: flesch: 55.0 cache: ./cache/cord-264889-1vsvcza2.txt txt: ./txt/cord-264889-1vsvcza2.txt summary: We certainly could not know that we would face that challenge in complementary roles-as patient and as critical care physician. Like so many other friends from distant pasts, we reconnected on social media, sharing advice and personal experiences during the current pandemic. " Although the critical care community is changing practice to improve outcomes (1-3), our shared experience of COVID delirium-one as patient and the other as physicianfriend-offered a powerful lesson for both of us. Each patient''s ties to the outside serve as reminders of the importance of team-the care team and the patient''s own team of partner, friends, and family-during the critical care journey. Thus, a partner can become a "project manager" to help share in the patient experience. As friends on a COVID journey, we shared our appreciation of ICU care as a team sport. COVID-19: ICU delirium management during SARS-CoV-2 pandemic COVID-19: What do we need to know about ICU delirium during the SARS-CoV-2 pandemic? abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33134943/ doi: 10.1097/cce.0000000000000250 id: cord-312486-rumqopg0 author: Jacob, Chaim Oscar title: On the genetics and immunopathogenesis of COVID-19 date: 2020-09-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Most severe cases with COVID-19, especially those with pulmonary failure, are not a consequence of viral burden and/or failure of the ‘adaptive’ immune response to subdue the pathogen by utilizing an adequate ‘adaptive’ immune defense. Rather it is a consequence of immunopathology, resulting from imbalanced innate immune response, which may not be linked to pathogen burden at all. In fact, it might be described as an autoinflammatory disease. The Kawasaki-like disease seen in children with SARS-CoV-2 exposure might be another example of similar mechanism. url: https://api.elsevier.com/content/article/pii/S1521661620307518 doi: 10.1016/j.clim.2020.108591 id: cord-276621-9exp8e7h author: Jacobs, Jeremy M. title: Prolonged Mechanical Ventilation: Symptomatology, Well-Being, and Attitudes to Life date: 2020-09-06 words: 4430.0 sentences: 223.0 pages: flesch: 48.0 cache: ./cache/cord-276621-9exp8e7h.txt txt: ./txt/cord-276621-9exp8e7h.txt summary: This study aims to describe the mood, well-being, distressing symptoms, and attitudes toward prolonged ventilation among PMV patients treated either at home or long-term acute care (LTAC). RESULTS: Participants were aged 61.7 ± 20.7 years, commonly suffered progressive neuromuscular disease (43.5%) or chronic lung disease (29%), were functionally dependent, treated at home (64.5%) or LTAC (35.5%), and had a mean PMV duration of 36.6 months (interquartile range 10.8-114.1). Although no significant differences were observed in the severity of the 10 r-ESAS subitem symptoms between home and LTAC, nonetheless, well-being was reported as asymptomatic or mildly impaired by 54% of home PMV patients compared with 26% among long-term care, with similar rates of severely impaired well-being reported by 10% and 11% of patients, respectively. abstract: OBJECTIVE: Although prolonged mechanical ventilation (PMV) is increasingly common, little is known concerning patient symptom burden or attitudes toward PMV. This study aims to describe the mood, well-being, distressing symptoms, and attitudes toward prolonged ventilation among PMV patients treated either at home or long-term acute care (LTAC). DESIGN: An observational study. SETTING AND PARTICIPANTS: 62 communicative participants treated with PMV, aged ≥18 years, insurees of a single HMO, treated at home hospital or LTAC specializing in ventilation in Jerusalem. MEASURES: Sociodemographic characteristics; chronic conditions; functional status; symptom burden measured by revised Edmonton Symptomatic Assessment System (r-ESAS); attitudes toward PVM. RESULTS: Participants were aged 61.7 ± 20.7 years, commonly suffered progressive neuromuscular disease (43.5%) or chronic lung disease (29%), were functionally dependent, treated at home (64.5%) or LTAC (35.5%), and had a mean PMV duration of 36.6 months (interquartile range 10.8-114.1). The 5-item, short Geriatric Depression Scale identified depression among 38% of participants, and was less at home vs LTAC (34% vs 44%, P < .001). Mean revised Edmonton Symptom Assessment System score was 24.5 ± 14.8 (maximum severity = 100), and participants reported severe or distressing symptoms for tiredness (27%/20%), pain (10%/25%), anxiety (16%/14%), depression (9%/21%), drowsiness (12%/17%), shortness of breath (9%/15%), poor appetite (7%/9%), and nausea (0%/10%). Impaired general well-being was reported as severe, moderate, mild, or none among 15%, 40%, 30%, and 15%, respectively. Only 1 patient had advance directives concerning ventilation prior to intubation, and when asked if they had to choose again today, 85% of patients would again opt for ventilation. CONCLUSIONS AND IMPLICATIONS: Few PMV patients reported distressing symptoms, and 85% would choose ventilation if asked again. These findings might be useful in clinical practice to assist in decision making concerning prolonged ventilation. url: https://api.elsevier.com/content/article/pii/S1525861020306629 doi: 10.1016/j.jamda.2020.07.037 id: cord-267788-ukz2wz4a author: Jaffe, Allan S title: Myocardial injury in severe COVID-19 infection date: 2020-06-07 words: 1909.0 sentences: 121.0 pages: flesch: 51.0 cache: ./cache/cord-267788-ukz2wz4a.txt txt: ./txt/cord-267788-ukz2wz4a.txt summary: [1] [2] [3] [4] In this issue of the European Heart Journal, the group from Wuhan Renmin University describe, in one of the larger cohorts (n = 671) reported to date, the importance of increases in cardiac troponin I (cTnI) in patients with a COVID-19 infection who were sick enough to require respiratory support. However, in critically ill patients, supply-demand imbalance leading to myocardial injury is more common, 10 due to the metabolic stress of the infection because of tachycardia, hypoxia, acidosis, and hypotension with or without substantial pre-existing epicardial coronary disease. Although arrhythmias have been described in the present and other studies of COVID-19, it is not clear that, in the absence of drugs that prolong the QTc interval which some now use as therapy, the incidence of these are greater than one might expect from patients with any severe respiratory infection leading to myocardial injury. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32464642/ doi: 10.1093/eurheartj/ehaa447 id: cord-277818-8w15dz20 author: Jaichenco, Andre L. title: Infectious Disease Considerations for the Operating Room date: 2018-02-09 words: 9728.0 sentences: 528.0 pages: flesch: 39.0 cache: ./cache/cord-277818-8w15dz20.txt txt: ./txt/cord-277818-8w15dz20.txt summary: Hand hygiene is a well-known and effective solution to the problem of bacterial transmission within and across patients and is considered the most important and cost-effective individual intervention in the prevention of health care–associated infections in children and health care providers Compliance with the current "5 moments" World Health Organization guidelines could make a major inroad into reducing provider hand and workspace contamination. These findings have clinical implications for the risk of colonization and subsequent HCIs-for example, SSIs. This calls attention to the need to develop and enforce strict hand hygiene guidelines for personnel who are providing anesthesia care, but more importantly the need to increase compliance with environmental disinfection of the OR (between cases and terminal cleaning), and to study further the directions of the spread of pathogens in the OR and anesthesia work areas. abstract: The risk of infection transmission by anesthesia providers in their work area environment is reviewed. The dynamics of transmission and the strategies for preventing infection transmission in health care institutions are discussed. Anesthesiologists have long been patient safety advocates and have taken on increasing responsibility for preventing health care–associated infections. Anesthesia providers practice in a nonsterile environment within the operating room and have an impact on bacterial transmission and infection rates. Understanding the characteristics of transmission elements provides the practicing anesthesiologist with methods to protect susceptible patients and themselves to avoid spreading infection. It is vital to have in place proper systems to remove contaminated air to minimize the risk of airborne pathogens being transmitted by children. Preoperative patient skin and other bacterial reservoir decontamination and hand hygiene by anesthesia providers reduces contamination of the work area and IV access ports. Hand hygiene is a well-known and effective solution to the problem of bacterial transmission within and across patients and is considered the most important and cost-effective individual intervention in the prevention of health care–associated infections in children and health care providers Compliance with the current “5 moments” World Health Organization guidelines could make a major inroad into reducing provider hand and workspace contamination. Surgical antimicrobial prophylaxis is an essential tool to reduce the risk of postoperative infections, and the anesthesia team plays a central role in ensuring the proper timing of drug administration. Protocols, although effective, require continuous feedback and revision. url: https://api.elsevier.com/content/article/pii/B9780323429740000501 doi: 10.1016/b978-0-323-42974-0.00050-1 id: cord-017105-mljywm9p author: Jain, Amisha title: Pulmonary Complications of Obstetric and Gynecologic Conditions date: 2017-10-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The respiratory and the female reproductive systems are not embryologically or functionally related. However, the reproductive system can exert significant effects on the respiratory system as a result of the various hormonal changes that occur during a woman’s menstrual cycle and especially during pregnancy. In addition, there are several unique gynecologic and/or obstetric conditions that can directly affect the respiratory system. The following chapter reviews the effects of pregnancy on the respiratory system, as well as the special issues concerning the management of common respiratory conditions (e.g., pneumonia, asthma) during pregnancy. In addition it reviews several gynecologic disorders with unique pulmonary complications. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121584/ doi: 10.1007/978-3-319-69620-1_8 id: cord-016300-vw11c2wt author: Jain, Kewal K. title: Biomarkers of Pulmonary Diseases date: 2017-09-18 words: 5578.0 sentences: 271.0 pages: flesch: 42.0 cache: ./cache/cord-016300-vw11c2wt.txt txt: ./txt/cord-016300-vw11c2wt.txt summary: Association of ECM turnover with severity and outcome of COPD has been assessed in a prospective, observational, multicenter study, Global Initiative for Chronic Obstructive Lung Disease grades II to IV, and serum samples were analyzed at stable state, during exacerbation as well as 4 weeks after exacerbation (Stolz et al. A study has revealed that serum levels of the neuroendocrine activity biomarker chromagranin A (CgA) are increased in male smokers with impaired lung function, and are associated with both respiratory symptoms and the degree of airway obstruction (Sorhaug et al. Although the aim of management of patients with asthma is to control their symptoms and prevent exacerbations and morbidity of the disease, optimal management may require assessment and monitoring of biomarkers, i.e., objective measures of lung dysfunction and inflammation. Several biomarkers have been assessed following treatment with corticosteroids including measures of lung function, peripheral blood and sputum indices of inflammation, exhaled gases and breath condensates. abstract: Lungs and airways are affected by several pathologies, the most important of which are inflammation, infection and cancer. Some of the biomarkers of these pathologies are similar to those found in involvement of other organs. This chapter will briefly discuss general issues of biomarkers of pulmonary disorders listed in Table 16.1. Biomarkers of lung cancer are described in Chapter 13. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120545/ doi: 10.1007/978-1-4939-7431-3_16 id: cord-011181-9nvwk04v author: Jakimovska, Vesna Miloshevska title: Epidemiological characteristics and early complications after spinal cord injury in Former Yugoslav Republic of Macedonia date: 2019-08-19 words: 5363.0 sentences: 279.0 pages: flesch: 52.0 cache: ./cache/cord-011181-9nvwk04v.txt txt: ./txt/cord-011181-9nvwk04v.txt summary: STUDY DESIGN: Prospective cohort study OBJECTIVES: To describe epidemiological data and complications after acute traumatic spinal cord injury (tSCI) in Former Yugoslav Republic of Macedonia (FYROM). The University Clinic for Traumatology, Orthopedics, Anesthesia, Reanimation, Intensive Care Unit and Emergency Center (TOARILUC), Mother Teresa, Skopje, FYROM, is a level one trauma hospital and the only public hospital treating patients with SCI in the country. The purpose of this study was to prospectively investigate incidence, cause of injury, demography and SCI characteristics, acute phase mortality/ survival, and early complications after tSCI among patients admitted to the University Clinic for TOARILUC. The information included: demographic data (gender, age at injury, marital status, and employment status), past illnesses, addiction habits (smoking, drugs, and alcohol consumption), preadmission records from patients transported from other hospitals, type of transport to the hospital, date of admission and discharge from TOARILUC, cause and type of injury, associated injuries, and mortality. abstract: STUDY DESIGN: Prospective cohort study OBJECTIVES: To describe epidemiological data and complications after acute traumatic spinal cord injury (tSCI) in Former Yugoslav Republic of Macedonia (FYROM). SETTING: University Clinic for Traumatology, Orthopedics, Anesthesia and Intensive Care Unit and Emergency Center (TOARILUC), Mother Teresa, Skopje, FYROM. METHOD: During the inclusion period March 2015 to September 2016, 38 tSCI patients were included. MRI, CT scan, and clinical examinations including International Standards for Neurological Classification of SCI were performed at admission. The information included: demographic data, transport type, date of admission and discharge, past illnesses, addiction habits, cause and type of injury, injury level, associated injuries, injury-related complications, and mortality. RESULTS: Mean age was 43 years (median 41, range 17–83). Seventeen patients had a complete and 15 an incomplete SCI, six were unknown. Most frequent causes for tSCI were traffic accidents (42%) and falls (40%), 24% of the accidents were contracted at work. Sixteen patients were ventilator dependent at some point during the acute period. Common complications were pressure ulcers, gastrointestinal-related, and infections. Hospital length of stay (LOS) ranged from 1 to 73 days. The in-hospital mortality rate was 32%. CONCLUSION: The annual incidence of tSCI in FYROM was in 2015–16 13 persons/million inhabitants per year. The epidemiological profile of tSCI in FYROM implies that preventive measures should be taken to reduce incidence of accidents in traffic and at work places. The high mortality rate and complications underline further actions to improve the acute care of tSCI in FYROM. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223761/ doi: 10.1038/s41393-019-0342-9 id: cord-301340-lhh04pum author: Jamieson, Frances B. title: Human Torovirus: A New Nosocomial Gastrointestinal Pathogen date: 1998-11-17 words: 3401.0 sentences: 184.0 pages: flesch: 39.0 cache: ./cache/cord-301340-lhh04pum.txt txt: ./txt/cord-301340-lhh04pum.txt summary: Torovirus-like particles purified from stool specimens were further shown to be toroviruses on the basis of their morphology, immunospecific interactions with Breda virus antiserum, ability to elicit an immune response following infection, and the high degree of homology of the 3 end of their genome with that of the Berne and Breda viruses [19] . At a different time from that of study 1, patients whose stool specimens were positive for torovirus, rotavirus, or astrovirus by electron microscopy were enrolled in study 2. In torovirus-positive patients, stool specimens were examined daily by electron microscopy during the hospitalization and at follow-up. Nine additional torovirus-positive patients developed bloody diarrhea within 2-15 days after study enrollment and had no other pathogen in the stool sample. Stool specimens collected on a follow-up visit 2-6 months after study enrollment from 168 patients infected with torovirus showed that 14 were shedding the virus. abstract: Studies were undertaken to determine if human torovirus is associated with gastroenteritis and to examine the clinical features of torovirus illness in children. The fecal excretion of torovirus in patients with gastroenteritis was compared with that in matched asymptomatic controls in a case-control study. Toroviruses were identified in 72 (35.0%) of 206 gastroenteritis cases compared with 30 (14.5%) of 206 controls (P < .001). Clinical features of torovirus gastroenteritis in 172 patients positive for torovirus were compared with those of 115 patients infected with rotavirus or astrovirus. Persons infected with torovirus were more frequently immunocompromised (43.0% vs. 15.7%) and nosocomially infected (57.6% vs. 31.3%). They also experienced less vomiting (46.4% vs. 66.7%) but had more bloody diarrhea (11.2% vs. 1.8%). An antibody response to torovirus developed mainly in older, nonimmunocompromised children (P < .01). These studies demonstrate an association between torovirus excretion and gastroenteritis in the pediatric population among immunocompromised hospitalized patients and in previously healthy patients. url: https://www.ncbi.nlm.nih.gov/pubmed/9780245/ doi: 10.1086/314434 id: cord-016476-78r0rsio author: Jani, Meghna title: Management of the Rheumatoid Arthritis Patient with Interstitial Lung Disease date: 2017-11-29 words: 15238.0 sentences: 641.0 pages: flesch: 35.0 cache: ./cache/cord-016476-78r0rsio.txt txt: ./txt/cord-016476-78r0rsio.txt summary: Several risk factors of leflunomide-induced pneumonitis have been reported in small numbers of patients in case series and retrospective studies including preexisting lung disease [32, 35, 36] , a prescribed loading dose, smoking, low body weight [32] and increased C-reactive protein, hypoalbuminaemia, hypoxia and lymphopaenia [36] . Whilst experience of using abatacept in the context of pre-existing ILD is limited, a case report of rapid-onset interstitial pneumonia 2 days post initiation of Administration, MHRA medicines and healthcare products regulatory agency, NA data not available, RA rheumatoid arthritis a Includes cases reported as idiopathic pulmonary fibrosis, pulmonary fibrosis and pulmonary toxicity treatment has been described in a Japanese patient [103] . Association of disease activity with acute exacerbation of interstitial lung disease during tocilizumab treatment in patients with rheumatoid arthritis: a retrospective, case-control study abstract: The treatment of rheumatoid arthritis (RA) has undergone considerable changes over the last 15–20 years. With an expansion in the armamentarium of therapies available for RA comes a wider choice in selecting the best treatment in terms of comparative safety in the presence of comorbidities. Clinicians frequently encounter patients with RA-associated interstitial lung disease with uncontrolled joint disease and have to make decisions about the safest treatments in this context with the eventual goal of joint remission. In this chapter, available evidence is reviewed on the comparative pulmonary safety of non-biologic disease-modifying antirheumatic drugs (nbDMARDs), biologic DMARDs, biosimilars and targeted synthetic DMARDs in RA-ILD. In addition, the potential role for additional immunosuppression in RA-ILD is reviewed as well as overarching recommendations proposed for patient assessment to guide treatment decisions and management. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120764/ doi: 10.1007/978-3-319-68888-6_9 id: cord-271896-1ad18z11 author: Janowitz, Tobias title: Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series date: 2020-06-04 words: 3627.0 sentences: 202.0 pages: flesch: 47.0 cache: ./cache/cord-271896-1ad18z11.txt txt: ./txt/cord-271896-1ad18z11.txt summary: CONCLUSIONS: The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with COVID-19. Based on a national institute of health (nih)-endorsed Protocol to research Patient experience of cOViD-19, we collected longitudinal severity scores of five symptoms (cough, shortness of breath, fatigue, headaches and anosmia) and general unwellness on a four-point ordinal scale modelled on performance status scoring. Based on a national institute of health (nih)-endorsed Protocol to research Patient experience of cOViD-19, we collected longitudinal severity scores of five symptoms (cough, shortness of breath, fatigue, headaches and anosmia) and general unwellness on a four-point ordinal scale modelled on performance status scoring. The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with cOViD-19. abstract: OBJECTIVE: Treatment options for non-hospitalised patients with coronavirus disease 2019 (COVID-19) to reduce morbidity, mortality and spread of the disease are an urgent global need. The over-the-counter histamine-2 receptor antagonist famotidine is a putative therapy for COVID-19. We quantitively assessed longitudinal changes in patient reported outcome measures in non-hospitalised patients with COVID-19 who self-administered high-dose famotidine orally. DESIGN: Patients were enrolled consecutively after signing written informed consent. Data on demographics, COVID-19 diagnosis, famotidine use, drug-related side effects, temperature measurements, oxygen saturations and symptom scores were obtained using questionnaires and telephone interviews. Based on a National Institute of Health (NIH)-endorsed Protocol to research Patient Experience of COVID-19, we collected longitudinal severity scores of five symptoms (cough, shortness of breath, fatigue, headaches and anosmia) and general unwellness on a four-point ordinal scale modelled on performance status scoring. All data are reported at the patient level. Longitudinal combined normalised symptom scores were statistically compared. RESULTS: Ten consecutive patients with COVID-19 who self-administered high-dose oral famotidine were identified. The most frequently used famotidine regimen was 80 mg three times daily (n=6) for a median of 11 days (range: 5–21 days). Famotidine was well tolerated. All patients reported marked improvements of disease related symptoms after starting famotidine. The combined symptom score improved significantly within 24 hours of starting famotidine and peripheral oxygen saturation (n=2) and device recorded activity (n=1) increased. CONCLUSIONS: The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with COVID-19. url: https://doi.org/10.1136/gutjnl-2020-321852 doi: 10.1136/gutjnl-2020-321852 id: cord-297506-1xjgsz4y author: Jansen, Jaclyn H. title: A novel presentation of COVID-19 via community acquired infection date: 2020-03-31 words: 498.0 sentences: 39.0 pages: flesch: 66.0 cache: ./cache/cord-297506-1xjgsz4y.txt txt: ./txt/cord-297506-1xjgsz4y.txt summary: COVID-19 is a novel coronavirus first detected in Wuhan, China in late 2019. A 76 year old male patient presented with his wife for altered mental status and lethargy. She reported the patient had not had fevers at home or dry cough, however she had recently experienced a dry cough. The patient had no known history of pulmonary disease. When vital signs were obtained the patient was found to have an oxygen saturation of 70% on room air. The patient was then weaned and able to maintain oxygen saturation of 93% on 5 L via nasal cannula. The patient was admitted to the progressive care unit for respiratory support and COVID-19 rule out. On follow-up, patient tested positive for COVID-19 with declining respiratory status over the next 24 h. Features, evaluation and treatment coronavirus (COVID-19) Update: public health response to the coronavirus disease 2019 outbreak -United States abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2405469020300509 doi: 10.1016/j.visj.2020.100760 id: cord-349076-x3rjasg0 author: Jarczak, Dominik title: Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View date: 2020-08-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Sepsis is a life-threatening organ dysfunction, defined by a dysregulated host immune response to infection. During sepsis, the finely tuned system of immunity, inflammation and anti-inflammation is disturbed in a variety of ways. Both pro-inflammatory and anti-inflammatory pathways are upregulated, activation of the coagulation cascade and complement and sepsis-induced lymphopenia occur. Due to the manifold interactions in this network, the use of IgM-enriched intravenous immunoglobulins seems to be a promising therapeutic approach. Unfortunately, there is still a lack of evidence-based data to answer the important questions of appropriate patient populations, optimal timing and dosage of intravenous immunoglobulins. With this review, we aim to provide an overview of the role of immunoglobulins, with emphasis on IgM-enriched formulations, in the therapy of adult patients with sepsis and septic shock. url: https://www.ncbi.nlm.nih.gov/pubmed/32756325/ doi: 10.3390/ijms21155543 id: cord-308313-3speddao author: Jaspard, Marie title: Linezolid-Associated Neurologic Adverse Events in Patients with Multidrug-Resistant Tuberculosis, France date: 2020-08-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Linezolid is one of the most effective drugs for treating multidrug-resistant tuberculosis (MDR TB), but adverse effects remain problematic. We evaluated 57 MDR TB patients who had received >1 dose of linezolid during 2011–2016. Overall, patients received 600 mg/day of linezolid for a median of 13 months. In 33 (58%) patients, neurologic or ophthalmologic signs developed, and 18 (32%) had confirmed peripheral neuropathy, which for 78% was irreversible at 12 months after the end of TB treatment despite linezolid withdrawal. Among the 19 patients who underwent ophthalmologic evaluation, 14 patients had optic neuropathy that fully reversed for 2. A total of 16 (33%) of 49 patients had a linezolid trough concentration >2 mg/L, and among these, 14 (88%) experienced adverse effects. No significant association was found between trough concentration and neurologic toxicity. These findings suggest the need to closely monitor patients for neurologic signs and discuss optimal duration of linezolid treatment. url: https://www.ncbi.nlm.nih.gov/pubmed/32687026/ doi: 10.3201/eid2608.191499 id: cord-288009-8i3gsq9p author: Javor, S. title: Why not consider an endothelin receptor antagonist against SARS‐CoV‐2? date: 2020-04-25 words: 668.0 sentences: 50.0 pages: flesch: 46.0 cache: ./cache/cord-288009-8i3gsq9p.txt txt: ./txt/cord-288009-8i3gsq9p.txt summary: Medical Hypotheses journal homepage: www.elsevier.com/locate/mehy Bosentan is a dual endothelin-receptor antagonist approved for the treatment of pulmonary arterial hypertension (PAH) in New York Heart Association functional classification (NYHA) II-IV and in scleroderma patients [10] . Guo et al [13] described a case of 57-year-old man with influenza A (H7N9) virus infection initially treated with empirical antibacterial therapy and oseltamivir with progression to acute respiratory distress syndrome and mechanical ventilation. Ritonavir and lopinavir, given together to sup-press HIV-replication, have been associated with bosentan to treat PAH in HIV-infected patients without dosage adjustment of protease inhibitors with good tolerability [14] . In conclusion, we think bosentan could be considered, in association with other approved drugs, in the treatment of SARS-CoV-2 to improve hemodynamics, potentiate antiviral effects and to prevent lung fibrosis. Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells abstract: nan url: https://api.elsevier.com/content/article/pii/S0306987720305739 doi: 10.1016/j.mehy.2020.109792 id: cord-003533-8m0vyxq8 author: Jayathilaka, P. G. N. S. title: An outbreak of leptospirosis with predominant cardiac involvement: a case series date: 2019-03-18 words: 4148.0 sentences: 280.0 pages: flesch: 50.0 cache: ./cache/cord-003533-8m0vyxq8.txt txt: ./txt/cord-003533-8m0vyxq8.txt summary: We present a case series of severe leptospirosis with cardiac involvement observed during a period of one month at Colombo-North Teaching Hospital, Sri Lanka. CASE PRESENTATION: We report here five patients with severe leptospirosis complicated with cardiac involvement, admitted to a single medical ward, Colombo-North Teaching Hospital, Sri Lanka during a one-month period. In this case series, we describe a series of male patients with severe leptospirosis with cardiac involvement, presented to a single medical ward during a period of one month. By day eleven of illness he was completely recovered clinically and full blood count, liver function tests, renal function tests and ECG were normal. Patient was discharged from the ward on day 7 of illness with complete recovery and normal full blood count, renal and liver function tests. Despite adequate fluid resuscitation patient developed shock with low urine output on the same day of admission. abstract: BACKGROUND: Severe leptospirosis is known to cause multi organ dysfunction including cardiac involvement. In the clinical setting with limited resources, high degree of suspicion is needed to diagnose cardiac involvement including myocarditis. Although myocarditis is not reported as a common complication due to lack of diagnostic facilities, there are evidence to support myocarditis is more prevalent in post mortem studies of patients died due to leptospirosis. We present a case series of severe leptospirosis with cardiac involvement observed during a period of one month at Colombo-North Teaching Hospital, Sri Lanka. CASE PRESENTATION: We report here five patients with severe leptospirosis complicated with cardiac involvement, admitted to a single medical ward, Colombo-North Teaching Hospital, Sri Lanka during a one-month period. Out of six suspected leptospirosis patients admitted during that period, five in a raw developed severe leptospirosis with cardiac involvement. In this case series, four patients were confirmed serologically or quantitative PCR and one patient had possible leptospirosis. All patients developed shock during their course of illness. Two patients developed rapid atrial fibrillation. One patient had dynamic T wave changes in ECG and the other two had sinus tachycardia. Two patients had evidence of myocarditis in 2D echocardiogram, whereas other two patients had nonspecific findings and one patient had normal 2D echocardiogram. All five patients had elevated cardiac troponin I titre and it was normalized with the recovery. All five patients developed acute kidney injury. Four patients needed inotropic/vasopressor support to maintain mean arterial pressure and one patient recovered from shock with fluid resuscitation. All patients were recovered from their illness and repeat 2D echocardiograms after recovery did not show residual complications. One patient had serologically proven dengue co-infection with leptospirosis. CONCLUSIONS: Myocarditis and cardiac involvement in leptospirosis may be overlooked due to non-specific clinical findings and co-existing multi-organ dysfunction. Atypical presentation of this case series may be due to micro-geographic variation and unusual outbreak of leptospirosis. Co-infection of dengue with leptospirosis should be considered in managing patients especially in endemic areas. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423826/ doi: 10.1186/s12879-019-3905-7 id: cord-283513-3f4rsgzm author: Jaywant, Abhishek title: Behavioral interventions in acute COVID-19 recovery: A new opportunity for integrated care date: 2020-07-07 words: 1265.0 sentences: 82.0 pages: flesch: 35.0 cache: ./cache/cord-283513-3f4rsgzm.txt txt: ./txt/cord-283513-3f4rsgzm.txt summary: title: Behavioral interventions in acute COVID-19 recovery: A new opportunity for integrated care Here, we describe how neuropsychology and consultation-liaison psychiatry have collaborated to implement interventions within this unit to facilitate patients'' recovery. Consistent with early reports [4] , we have found a high prevalence of cognitive dysfunction in COVID-19 patients on our recovery unit. To facilitate orientation and memory, all patient rooms have a large whiteboard on which providers write their names and where patients'' rehabilitation goals and progress are recorded. Psychoeducation on rehabilitation; clinician-led mindfulness; virtual reality-based mindfulness; cognitive restructuring; problem-solving; brief psychotherapy scheduled prior to PT/OT; cognitive-behavioral psychotherapy group; chair yoga. Use of room whiteboard to track date, location, names of providers, and rehabilitation goals and progress; clinicians wear large ID tags and assist in reorientation; "memory books." Early intraintensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32654787/ doi: 10.1016/j.genhosppsych.2020.07.001 id: cord-321651-7e8dwcur author: Jazieh, Abdul-Rahman title: Managing Oncology Services During a Major Coronavirus Outbreak: Lessons From the Saudi Arabia Experience date: 2020-03-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Outbreaks of infectious etiology, particularly those caused by a novel virus that has no known treatment or vaccine, may result in the interruption of medical care provided to patients with cancer and put them at risk for undertreatment in addition to the risk of being exposed to infection, a life-threatening event among patients with cancer. This article describes the approach used to manage patients with cancer during a large-scale Middle East respiratory syndrome–coronavirus hospital outbreak in Saudi Arabia to ensure continuity of care and minimize harm from treatment interruption or acquiring infection. The approach taken toward managing this high-risk situation (COVID-19) could be easily adopted by health care organizations and would be helpful to ensure readiness for the occurrence of future outbreaks of different infectious etiologies like those recent episodes of new coronavirus. url: https://doi.org/10.1200/go.20.00063 doi: 10.1200/go.20.00063 id: cord-256639-4e0irb6d author: Jean-Michel, Vanessa title: Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation date: 2020-09-06 words: 842.0 sentences: 61.0 pages: flesch: 49.0 cache: ./cache/cord-256639-4e0irb6d.txt txt: ./txt/cord-256639-4e0irb6d.txt summary: title: Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation The Food and Drug Administration recently issued a midazolam shortage and reported a more than 50% consumption increase for other common sedative drugs such as propofol due to high demand for patients with COVID-19 [3] . For these patients, barbiturate therapy induce deep coma with bispectral index score lower than 20 and, as a result, prolonged MV [4] . Midazolam and propofol were completely stopped one hour after the thiopental loading dose in all patients. Another drug option for sedation of critically ill patients with COVID-19 could be inhaled volatile anaesthetics [9, 10] . Some studies have reported that inhaled agents such as isoflurane and sevoflurane shorten awakening and extubation times in mechanically ventilated patients compared to benzodiazepines or propofol. Thiopental seems to be an acceptable substitute to sedative drugs in this period of high midazolam and propofol demand for ICU patients with COVID-19. abstract: nan url: https://doi.org/10.1016/j.medin.2020.07.013 doi: 10.1016/j.medin.2020.07.013 id: cord-260037-ys62jrgw author: Jecker, Nancy S. title: Ebola Virus Disease Ethics and Emergency Medical Response Policy date: 2015-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Caring for patients affected with Ebola virus disease (EVD) while simultaneously preventing EVD transmission represents a central ethical challenge of the EVD epidemic. To address this challenge, we propose a model policy for resuscitation and emergent procedure policy of patients with EVD and set forth ethical principles that lend support to this policy. The policy and principles we propose bear relevance beyond the EVD epidemic, offering guidance for the care of patients with other highly contagious, virulent, and lethal diseases. The policy establishes (1) a limited code status for patients with confirmed or suspected EVD. Limited code status means that a code blue will not be called for patients with confirmed or suspected EVD at any stage of the disease; however, properly protected providers (those already in full protective equipment) may initiate resuscitative efforts if, in their clinical assessment, these efforts are likely to benefit the patient. The policy also requires that (2) resuscitation not be attempted for patients with advanced EVD, as resuscitation would be medically futile; (3) providers caring for or having contact with patients with confirmed or suspected EVD be properly protected and trained; (4) the treating team identify and treat in advance likely causes of cardiac and respiratory arrest to minimize the need for emergency response; (5) patients with EVD and their proxies be involved in care discussions; and (6) care team and provider discretion guide the care of patients with EVD. We discuss ethical issues involving medical futility and the duty to avoid harm and propose a utilitarian-based principle of triage to address resource scarcity in the emergency setting. url: https://www.ncbi.nlm.nih.gov/pubmed/25855946/ doi: 10.1378/chest.15-0135 id: cord-353200-5csewb1k author: Jehi, Lara title: Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19 date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus Disease 2019 is a pandemic that is straining healthcare resources, mainly hospital beds. Multiple risk factors of disease progression requiring hospitalization have been identified, but medical decision-making remains complex. OBJECTIVE: To characterize a large cohort of patients hospitalized with COVID-19, their outcomes, develop and validate a statistical model that allows individualized prediction of future hospitalization risk for a patient newly diagnosed with COVID-19. DESIGN: Retrospective cohort study of patients with COVID-19 applying a least absolute shrinkage and selection operator (LASSO) logistic regression algorithm to retain the most predictive features for hospitalization risk, followed by validation in a temporally distinct patient cohort. The final model was displayed as a nomogram and programmed into an online risk calculator. SETTING: One healthcare system in Ohio and Florida. PARTICIPANTS: All patients infected with SARS-CoV-2 between March 8, 2020 and June 5, 2020. Those tested before May 1 were included in the development cohort, while those tested May 1 and later comprised the validation cohort. MEASUREMENTS: Demographic, clinical, social influencers of health, exposure risk, medical co-morbidities, vaccination history, presenting symptoms, medications, and laboratory values were collected on all patients, and considered in our model development. RESULTS: 4,536 patients tested positive for SARS-CoV-2 during the study period. Of those, 958 (21.1%) required hospitalization. By day 3 of hospitalization, 24% of patients were transferred to the intensive care unit, and around half of the remaining patients were discharged home. Ten patients died. Hospitalization risk was increased with older age, black race, male sex, former smoking history, diabetes, hypertension, chronic lung disease, poor socioeconomic status, shortness of breath, diarrhea, and certain medications (NSAIDs, immunosuppressive treatment). Hospitalization risk was reduced with prior flu vaccination. Model discrimination was excellent with an area under the curve of 0.900 (95% confidence interval of 0.886–0.914) in the development cohort, and 0.813 (0.786, 0.839) in the validation cohort. The scaled Brier score was 42.6% (95% CI 37.8%, 47.4%) in the development cohort and 25.6% (19.9%, 31.3%) in the validation cohort. Calibration was very good. The online risk calculator is freely available and found at https://riskcalc.org/COVID19Hospitalization/. LIMITATION: Retrospective cohort design. CONCLUSION: Our study crystallizes published risk factors of COVID-19 progression, but also provides new data on the role of social influencers of health, race, and influenza vaccination. In a context of a pandemic and limited healthcare resources, individualized outcome prediction through this nomogram or online risk calculator can facilitate complex medical decision-making. url: https://www.ncbi.nlm.nih.gov/pubmed/32780765/ doi: 10.1371/journal.pone.0237419 id: cord-286418-9ho5fg3h author: Jenkins, Ian title: Lessons from Walking the Medical Distancing Tightrope date: 2020-05-28 words: 2625.0 sentences: 144.0 pages: flesch: 45.0 cache: ./cache/cord-286418-9ho5fg3h.txt txt: ./txt/cord-286418-9ho5fg3h.txt summary: Like many academic programs before the pandemic, UCSD''s Division of Hospital Medicine emphasized interdisciplinary bedside rounding, focusing on clinical care, quality, patient experience, and teaching. SARS-CoV2, capable of spreading from presymptomatic and asymptomatic persons, 3 threatened to injure or kill high-risk hospitalized patients (i.e. elderly, or with comorbid illnesses) as well as healthcare workers (HCW), making them patients instead of caregivers during our projected surge. 8 For example, on April 9, UCSD Health had a total census of 471 patients (56% occupancy) of which only 4.2% had COVID, with 10 patients on the hospital medicine service, 8 on ventilators (5.2% of capacity), and only 3 total deaths to date. AAMC guidelines advise that medical students not be involved in patient care unless COVID risks are low and protective equipment and testing are available. 12 As we contemplate the future of hospital care and training, we continue to monitor our distancing efforts for signs of adverse effects on safety, efficiency, and experience. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32620508/ doi: 10.1016/j.jcjq.2020.05.006 id: cord-341933-dwki1hwu author: Jeong, Han-Gil title: Therapeutic Temperature Modulation for a Critically Ill Patient with COVID-19 date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We report a rapidly deteriorating coronavirus disease 2019 (COVID-19) patient, a-58-year-old woman, with severe acute respiratory distress syndrome and shock with hyperpyrexia up to 41.8°C, probably due to the cytokine storm syndrome. Considering extracorporeal membrane oxygenation (ECMO) as the last resort, we applied therapeutic temperature modulation for management of hyperpyrexia. The patient demonstrated rapid improvement in oxygenation and shock after achieving normothermia, and fully recovered from COVID-19 three weeks later. Therapeutic temperature modulation may have successfully offloaded the failing cardiorespiratory system from metabolic cost and hyperinflammation induced by hyperpyrexia. The therapeutic temperature modulation can safely be applied in a specific group of patients with cytokine storm syndrome and hyperpyrexia, which may reduce the number of patients requiring ECMO in the global medical resource shortage. url: https://www.ncbi.nlm.nih.gov/pubmed/32508069/ doi: 10.3346/jkms.2020.35.e210 id: cord-341415-g781zhu6 author: Jhaveri, Kenar D. title: Thrombotic microangiopathy in a patient with COVID-19 date: 2020-06-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0085253820306293?v=s5 doi: 10.1016/j.kint.2020.05.025 id: cord-349210-8t4a5qqo author: Ji, Ping title: Immunomodulatory Therapeutic Proteins in COVID‐19: Current Clinical Development and Clinical Pharmacology Considerations date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID‐19 pandemic caused by infection with SARS‐CoV‐2 has led to more than 600,000 deaths worldwide. Patients with severe disease often experience acute respiratory distress characterized by upregulation of multiple cytokines. Immunomodulatory biological therapies are being evaluated in clinical trials for the management of the systemic inflammatory response and pulmonary complications in patients with advanced stages of COVID‐19. In this review, we summarize the clinical pharmacology considerations in the development of immunomodulatory therapeutic proteins for mitigating the heightened inflammatory response identified in COVID‐19. This article is protected by copyright. All rights reserved url: https://doi.org/10.1002/jcph.1729 doi: 10.1002/jcph.1729 id: cord-327641-hqnem2zs author: Ji, Ying-Jie title: Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone date: 2016-11-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Clinical and laboratory data were collected and analysed from patients with Ebola virus disease (EVD) in Jui Government Hospital in Freetown, Sierra Leone, where patients with EVD were received and/or treated from October 1, 2014 to March 21, 2015 during the West Africa EVD outbreak. METHODS: The study admitted 285 patients with confirmed EVD and followed them up till the endpoint (recovery or death). EVD was confirmed by quantitative RT-PCR assays detecting blood Ebola virus (EBOV). RESULTS: Among the 285 lab-confirmed EVD cases in Jui Government Hospital, 146 recovered and 139 died, with an overall survival rate of 51.23 %. Patients under the age of 6 years had a lower survival rate (37.50 %). Most non-survivors (79.86 %) died within 7 days after admission and the mean hospitalization time for non-survivors was 5.56 ± 6.11 days. More than half survivors (63.69 %) turned blood EBOV negative within 3 weeks after admission and the mean hospitalization time for survivors was 20.38 ± 7.58 days. High blood viral load (≥10(6) copies/ml) was found to be predictive of the non-survival outcome as indicated by the Receiver Operating Characteristic (ROC) curve analysis. The probability of patients’ survival was less than 15 % when blood viral load was greater than 10(6) copies/ml. Multivariate analyses showed that blood viral load (P = 0.005), confusion (P = 0.010), abdominal pain (P = 0.003), conjunctivitis (P = 0.035), and vomiting (P = 0.004) were factors independently associated with the outcomes of EVD patients. CONCLUSIONS: Most death occurred within 1 week after admission, and patients at the age of 6 or younger had a lower survival rate. Most surviving patients turned blood EBOV negative within 1–4 weeks after admission. Factors such as high blood viral load, confusion, abdominal pain, vomiting and conjunctivitis were associated with poor prognosis for EVD patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40249-016-0195-9) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/27806732/ doi: 10.1186/s40249-016-0195-9 id: cord-321594-x5wv9p7n author: Jiang, Wen title: Equal Access to Telemedicine during COVID‐19 Pandemic: A Pediatric Otolaryngology Perspective date: 2020-10-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES/HYPOTHESIS: During the current COVID‐19 pandemic, the demand for direct‐to‐home telemedicine services has risen to an unprecedented level. Equal access to specialty care was assessed to identify potential barriers that may negatively impact telemedicine utilization. STUDY DESIGN: Retrospective case series. METHODS: We examined the 6‐week period between March and May 2020 when the only access to nonurgent pediatric otolaryngology service was through telemedicine and compared it to in‐person visits during the same period in 2019. We compared patient demographics, including age, gender, preferred language, zip code of residence, and primary insurance plan. RESULTS: A total of 1,495 visits were conducted through telemedicine from March 23, 2020 to May 1, 2020, and 1983 in‐person visits were completed in 2019. There was no difference in patient age and gender. The proportions of Spanish‐speaking families were similar (15.8% in 2019 vs. 14.4% in 2020, P = .96). The percentage of Medi‐Cal‐insured patients (51.4% in 2019 vs. 49.8% in 2020, P = .73) and the mean poverty level (12.6% in 2019 vs. 12.2% in 2020, P = .38) also remained the same. Spanish‐speaking families were statistically more likely to require rescheduling of their telemedicine visits (17.2%) when compared to the overall rescheduling rate of 11.9% (P = .0083). CONCLUSIONS: We were able to successfully provide access to telemedicine services to our vulnerable populations during the current COVID‐19 pandemic. Telemedicine is likely to remain an essential mode of delivering patient care going forward. It is important to evaluate and identify potential disparities to telemedicine access and proactively implement changes to address these barriers. LEVEL OF EVIDENCE: 4. Laryngoscope, 2020 url: https://www.ncbi.nlm.nih.gov/pubmed/32969043/ doi: 10.1002/lary.29164 id: cord-346459-tkt5ldyo author: Jie, Li Shao title: Risk factors for Coronavirus disease 2019 pneumonia after admission outside Wuhan, China date: 2020-11-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19) has spread worldwide, causing significant stress on the medical system. We explored the risk factors for condition changes in COVID-19 pneumonia patients after admission. The patients diagnosed with COVID-19 pneumonia at 2 medical centers in Hunan Province were studied, and those whose conditions changed after admission were compared. Their clinical characteristics and experimental indicators were compared using SPSS software and R language to build a disease risk prediction model. Patients with condition changes after admission were older and had more blood cell abnormalities and impaired organ function (decreased albumin, elevated D-dimer) than normal patients. We found that age, neutrophil ratio, D-dimer, chest Computed tomograpgy (CT) changes, and glucocorticoid use were risk factors for COVID-19 pneumonia after admission. Elderly patients are more susceptible to disease changes after COVID-19 pneumonia; COVID-19 pneumonia patients who develop disease changes after admission have higher neutrophil ratios, increased D-dimer levels, chest imaging changes, and glucocorticoid usage. Additional research is needed. url: https://doi.org/10.1097/md.0000000000022980 doi: 10.1097/md.0000000000022980 id: cord-253168-b095rq5i author: Jiménez-Blanco Bravo, Marta title: Heart Failure in the Time of COVID-19 date: 2020-06-26 words: 1304.0 sentences: 66.0 pages: flesch: 54.0 cache: ./cache/cord-253168-b095rq5i.txt txt: ./txt/cord-253168-b095rq5i.txt summary: OBJECTIVE: The aim of this study was to evaluate the results of a follow-up protocol established in an advanced heart failure unit at a single center in Spain during the coronavirus disease 2019 (COVID-19) pandemic. RESULTS: When compared to the preceding months, during the COVID pandemic there was a 56.5% reduction in the ER visits and a 46.9% reduction in hospital admissions, without an increase in mortality (9 patients died in both time periods). CONCLUSION: Our study suggests that implementing an active-surveillance protocol in acutely decompensated heart failure units during the SARS-CoV-2 pandemic can reduce hospital admissions, ER visits and, potentially, viral transmission, in a cohort of especially vulnerable patients. Our study suggests that implementing an active-surveillance protocol in HFUs during the SARS-CoV-2 pandemic can reduce hospital admissions, ER visits and, potentially, viral transmission, in a cohort of especially vulnerable patients. abstract: BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a new threat to healthcare systems. In this setting, heart failure units have faced an enormous challenge: taking care of their patients while at the same time avoiding patients' visits to the hospital. OBJECTIVE: The aim of this study was to evaluate the results of a follow-up protocol established in an advanced heart failure unit at a single center in Spain during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: During March and April 2020, a protocolized approach was implemented in our unit to reduce the number of outpatient visits and hospital admissions throughout the maximum COVID-19 spread period. We compared emergency room (ER) visits, hospital admissions, and mortality with those of January and February 2020. RESULTS: When compared to the preceding months, during the COVID pandemic there was a 56.5% reduction in the ER visits and a 46.9% reduction in hospital admissions, without an increase in mortality (9 patients died in both time periods). A total of 18 patients required a visit to the outpatient clinic for decompensation of heart failure or others. CONCLUSION: Our study suggests that implementing an active-surveillance protocol in acutely decompensated heart failure units during the SARS-CoV-2 pandemic can reduce hospital admissions, ER visits and, potentially, viral transmission, in a cohort of especially vulnerable patients. url: https://doi.org/10.1159/000509181 doi: 10.1159/000509181 id: cord-334790-lav794w0 author: Jin, Huijuan title: Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists date: 2020-04-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID‐19) has become a pandemic disease globally. Although COVID-19 directly invades lungs, it also involves the nervous system. Therefore, patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed. They become silent contagious sources or ‘virus spreaders’. In order to help neurologists to better understand the occurrence, development and prognosis, we have developed this consensus of prevention and management of COVID‐19. It can also assist other healthcare providers to be familiar with and recognise COVID-19 in their evaluation of patients in the clinic and hospital environment. url: https://www.ncbi.nlm.nih.gov/pubmed/32385132/ doi: 10.1136/svn-2020-000382 id: cord-325234-skshcrh1 author: Jin, Tingxu title: SARS-CoV-2 presented in the air of an intensive care unit (ICU) date: 2020-08-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As coronavirus disease 2019 (COVID-19) is spreading worldwide, there have been arguments regarding the aerosol transmission of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, some re-detectable positive (RP) patients have been reported. However, little attention has been given to the follow-up of recovered patients, and there is no environmental evidence to determine whether these patients continue to shed the virus after they test negative. Therefore, with an objective to test the hypothesis of airborne transmission of SARS-CoV-2, it is necessary to 1) determine whether SARS-CoV-2 particles are present in the indoor air and 2) determine whether recovered patients are still shedding virus, thus providing much-needed environmental evidence for the management of COVID-19 patients during the recovery period. In this study, surface and air samples were collected from an intensive care unit (ICU) containing one ready-for-discharge patient. All surface samples tested negative, but the air samples tested positive for SARS-CoV-2. This implies that SARS-CoV-2 particles may be shed in aerosol form for days after patients test negative. This finding may be one of the reasons for the observation of RP patients; therefore, there is a need for improved clinical and disease management guidelines for recovered COVID-19 patients. url: https://www.sciencedirect.com/science/article/pii/S2210670720306661?v=s5 doi: 10.1016/j.scs.2020.102446 id: cord-025749-mip9mkef author: Jo, Sungyang title: Newly developed stroke in patients admitted to non-neurological intensive care units date: 2020-06-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Little is known about newly developed stroke in patients admitted to the intensive care unit (ICU). OBJECTIVE: This study aimed to investigate characteristics and outcomes of newly developed stroke in patients admitted to the non-neurological intensive care units (ICU-onset stroke, IOS). METHODS: A consecutive series of adult patients who were admitted to the non-neurological ICU were included in this study. We compared neurological profiles, risk factors, and mortality rates between patients with IOS and those without IOS. RESULTS: Of 18,604 patients admitted to the ICU for non-neurological illness, 218 (1.2%) developed stroke (ischemic, n = 182; hemorrhagic, n = 36). The most common neurological presentation was altered mental status (n = 149), followed by hemiparesis (n = 55), and seizures (n = 28). The most common etiology of IOS was cardioembolism (50% [91/182]) for ischemic IOS and coagulopathy (67% [24/36]) for hemorrhagic IOS. In multivariable analysis, the Acute Physiology and Chronic Health Evaluation II (APACHE II) score (adjusted odds ratio [AOR] = 1.04, 95% CI = 1.03−1.06, P < 0.001), prothrombin time (AOR = 0.99, 95% CI = 0.98−0.99, P = 0.013), cardiovascular surgery (AOR = 1.84, 95% CI = 1.34−2.50, P < 0.001), mechanical ventilation (AOR = 6.75, 95% CI = 4.87−9.45, P < 0.001), and extracorporeal membrane oxygenation (AOR = 2.77, 95% CI = 1.62−4.55, P < 0.001) were related to the development of IOS. Stroke was associated with increased 3-month mortality after hospital discharge (AOR, 2.20; 95% CI, 1.58–3.05; P < 0.001), after adjustment for APACHE II and comorbidities. CONCLUSIONS: Patients who developed IOS had characteristics of initial critical illness and managements performed in the ICU as well as neurological presentations. The occurrence of IOS was related to high morbidity and mortality. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00415-020-09955-5) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264485/ doi: 10.1007/s00415-020-09955-5 id: cord-002853-vj8t28hn author: Joffe, Michael title: Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient date: 2018-01-27 words: 2128.0 sentences: 112.0 pages: flesch: 41.0 cache: ./cache/cord-002853-vj8t28hn.txt txt: ./txt/cord-002853-vj8t28hn.txt summary: BACKGROUND: We report a fatal case of disseminated adenovirus infection in a non-transplant haematology adult patient with chronic lymphocytic leukaemia who had completed combination chemoimmunotherapy a few months before developing respiratory symptoms. CASE PRESENTATION: This case started with an initial bacterial chest infection that responded to treatment, followed by an adenovirus pneumonitis that disseminated to his blood a week later with levels of up to 92 million adenovirus DNA copies/ml. We report here a case of adenovirus pneumonitis which led to a fatal disseminated adenovirus infection in an adult patient with chronic lymphocytic leukaemia (CLL) on chemotherapy. This patient''s chemotherapy regimen included fludarabine which has severe lymphopaenia as a recognised adverse effect, and which has been present in treatment regimens where various other viral reactivations have occurred, including hepatitis B [10] [11] [12] , BK virus [13] , herpes simplex and Epstein-Barr viruses [14] , cytomegalovirus [15] , as well as adenovirus [16] . abstract: BACKGROUND: We report a fatal case of disseminated adenovirus infection in a non-transplant haematology adult patient with chronic lymphocytic leukaemia who had completed combination chemoimmunotherapy a few months before developing respiratory symptoms. In such non-transplant patients, monitoring for adenovirus in the blood is not routine. However, with adenoviruses, when there is a more peripheral (i.e. non-blood) site of infection such as the chest, serial adenovirus monitoring in blood for the duration of that illness may be warranted. CASE PRESENTATION: This case started with an initial bacterial chest infection that responded to treatment, followed by an adenovirus pneumonitis that disseminated to his blood a week later with levels of up to 92 million adenovirus DNA copies/ml. Despite prompt treatment with cidofovir, his respiratory function continued to deteriorate over the next two weeks and he was moved to intensive care. Intravenous immunoglobulin and ribavirin were subsequently added to his treatment. However, he died soon after this with a final adenovirus load of 20 million copies/ml in his blood. CONCLUSIONS: We recommend that even in non-transplant haematology patients, where such patients present with an acute respiratory adenovirus infection, teams should consider checking the blood for adenovirus to check for signs of disseminated infection. The earlier this can be tested, the earlier treatment can be initiated (if adenovirus positive), which may produce more successful clinical outcomes. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787257/ doi: 10.1186/s12879-018-2962-7 id: cord-334524-8uqnlpvc author: Johannson, Kerri A. title: Remote Monitoring in Idiopathic Pulmonary Fibrosis: Home Is Where the Bluetooth-enabled Spirometer Is date: 2020-08-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1164/rccm.202005-1532ed doi: 10.1164/rccm.202005-1532ed id: cord-029606-2z1tw4xo author: John, Janice title: Developing an Intensive Community Covid-19 Management Strategy: Helping Our Patients Access Patient-Centered Care across a Continuum of Covid-19 Disease Needs date: 2020-05-27 words: 3161.0 sentences: 165.0 pages: flesch: 49.0 cache: ./cache/cord-029606-2z1tw4xo.txt txt: ./txt/cord-029606-2z1tw4xo.txt summary: An intensive community management strategy, including outreach to high-risk patients, dedicated telephone triage, and a respiratory clinic, can reduce hospitalizations and improve outcomes for Covid-19. Our model spans the continuum of care and includes six key components: high-risk outreach, telephonic primary care, a phone triage system, a community management group, a respiratory clinic, and integrated emergency room/hospital care ( Figure 1 ). The triage center is a dedicated group of nurses supported by onsite physicians who (1) determine whether patients'' symptoms are clinically consistent with Covid-19 using a symptom checklist, (2) risk-stratify patients for severe disease complications using risk stratification criteria (Table 1) (3) determine whether patients meet criteria for testing, (4) conduct robust education (about 10-15 min) on home care with attention to self-isolation and selfquarantine and (5) evaluate patients for symptoms requiring urgent in-person assessment at the respiratory clinic based on identification of potential pulmonary involvement. abstract: An intensive community management strategy, including outreach to high-risk patients, dedicated telephone triage, and a respiratory clinic, can reduce hospitalizations and improve outcomes for Covid-19. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371307/ doi: 10.1056/cat.20.0181 id: cord-273045-ele1cz86 author: Johnson, Claire D. title: Response of Practicing Chiropractors during the Early Phase of the COVID-19 Pandemic: A Descriptive Report date: 2020-06-13 words: 13963.0 sentences: 878.0 pages: flesch: 54.0 cache: ./cache/cord-273045-ele1cz86.txt txt: ./txt/cord-273045-ele1cz86.txt summary: authors: Johnson, Claire D.; Green, Bart N.; Konarski-Hart, Karen K.; Hewitt, Elise G.; Napuli, Jason G.; Foshee, William K.; Brown, Jason W.; Kopansky-Giles, Deborah; Stuber, Kent J.; Lerede, Caterina; Charlton, Scott T.; Field, Jonathan R.; Botelho, Marcelo B.; Da Silva, Kendrah L.; Tønner, Gitte; Yap, Terrence BK.; Gkolfinopoulos, Vasileios S.; Quintero, Gabriel; Agaoglu, Mustafa H. 68 The Texas Board of Chiropractic Examiners issued guidelines on appropriateness of chiropractic care through April 30 that stated, "Licensees should only provide essential chiropractic services for patients with current or recurrent complaints of pain or disability which adversely affects the patient''s ability to engage in the essential activities of daily living or work, or adversely affects the patient''s quality of life, and with anticipation of material improvement under chiropractic care." 69 As of May 1, updated orders included that licensed chiropractors could provide wellness care but, "should continue to adhere to safety and prevention best practices specified in the most current advice from the Centers for Disease Control." 70 William Foshee. abstract: OBJECTIVE: The coronavirus disease-2019 (COVID-19) pandemic has strained all levels of healthcare and it is not known how chiropractic practitioners have responded to this crisis. The purpose of this report is to describe responses by a sample of chiropractors during the early stages of the COVID-19 pandemic. METHODS: We used a qualitative-constructivist design to understand chiropractic practice during the COVID-19 pandemic, as described by the participants. A sample of chiropractic practitioners (doctors of chiropractic, chiropractors) from various international locations were invited to participate. Each described the public health response to COVID-19 in their location and the actions that they took in their chiropractic practices from April 20 through May 4, 2020. A summary report was created from their responses and common themes were identified. RESULTS: Eighteen chiropractic practitioners representing 17 locations and 11 countries participated. A variety of practice environments were represented in this sample, including, solo practice, mobile practice, private hospital, US Veterans Administration health care, worksite health center, and group practice. They reported that they recognized and abided by changing governmental regulations. They observed their patients experience increased stress and mental health concerns resulting from the pandemic. They adopted innovative strategies, such as telehealth, to do outreach, communicate with, and provide care for patients. They abided by national and World Health Organization recommendations and they adopted creative strategies to maintain connectivity with patients through a people-centered, integrated, and collaborative approach. CONCLUSION: Although the chiropractors in this sample practiced in different cities and countries, their compliance with local regulations, concern for staff and patient safety, and people-centered responses were consistent. This sample covers all 7 World Federation of Chiropractic regions (ie, African, Asian, Eastern Mediterranean, European, Latin American, North American, and Pacific) and provides insights into measures taken by chiropractors during the early stages of the COVID-19 pandemic. This information may assist the chiropractic profession as it prepares for different scenarios as new evidence about this disease evolves. url: https://api.elsevier.com/content/article/pii/S0161475420301226 doi: 10.1016/j.jmpt.2020.05.001 id: cord-305534-936peb1n author: Johnson, Kemmian D. title: Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19 date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome coronavirus−2 (SARS-CoV-2) has been recently identified as the culprit of the highly infectious, outbreak named coronavirus disease 2019 (COVID-19) in China. Now declared a public health emergency, this pandemic is present in more than 200 countries with over 14 million cases and 600,000 deaths as of July 18, 2020. Primarily transmitted through the respiratory tract, the most common clinical presentations of symptomatic individuals infected with SARS-CoV-2 include fever, dyspnea, cough, fatigue, and sore throat. In advanced cases, patients may rapidly develop respiratory failure with acute respiratory distress syndrome, and even progress to death. While it is known that COVID-19 manifests similarly to the 2003 Severe Acute Respiratory Syndrome (SARS) and the 2012 Middle East Respiratory Syndrome (MERS), primarily affecting the pulmonary system, the impact of the disease extends far beyond the respiratory system and affects other organs of the body. The literature regarding the extrapulmonary manifestations (cardiovascular, renal, hepatic, gastrointestinal, ocular, dermatologic, and neurological) of COVID-19 is scant. Herein, we provide a comprehensive review of the organ-specific clinical manifestations of COVID-19, to increase awareness about the various organs affected by SARS-CoV-2 and to provide a brief insight into the similarities and differences in the clinical manifestations of COVID-19 and the earlier SARS and MERS. url: https://doi.org/10.3389/fmed.2020.00526 doi: 10.3389/fmed.2020.00526 id: cord-309728-7vfotgrr author: Johnson, Kristen M. title: Managing COVID‐19 in Renal Transplant Recipients: A Review of Recent Literature and Case Supporting Corticosteroid‐sparing Immunosuppression date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Novel coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome virus (SARS‐CoV‐2) has become a global health care crisis. The Centers for Disease Control and Prevention (CDC) lists immunocompromised patients, including those requiring immunosuppression following renal transplantation, as high risk for severe disease from SARS‐CoV‐2. Treatment for other viral infections in renal transplant recipients often includes a reduction in immunosuppression; however, no current guidelines are available recommending the optimal approach to managing immunosuppression in the patients who are infected with SARS‐CoV‐2. It is currently advised to avoid corticosteroids in the treatment of SARS‐CoV‐2 outside of critically ill patients. Recently published cases describing inpatient care of COVID‐19 in renal transplant recipients differ widely in disease severity, time from transplantation, baseline immunosuppressive therapy, and the modifications made to immunosuppression during COVID‐19 treatment. This review summarizes and compares inpatient immunosuppressant management strategies of recently published reports in the renal transplant population infected with SARS‐CoV‐2 and discusses the limitations of corticosteroids in managing immunosuppression in this patient population. url: https://www.ncbi.nlm.nih.gov/pubmed/32339304/ doi: 10.1002/phar.2410 id: cord-273875-vpp0l6ij author: Johnson, Miguel title: Creating a ‘safe haven’ for the most vulnerable; Early Reports of Management Strategies for Breast Cancer Patients in the UK during the COVID -19 Pandemic times date: 2020-09-20 words: 766.0 sentences: 40.0 pages: flesch: 49.0 cache: ./cache/cord-273875-vpp0l6ij.txt txt: ./txt/cord-273875-vpp0l6ij.txt summary: title: Creating a ''safe haven'' for the most vulnerable; Early Reports of Management Strategies for Breast Cancer Patients in the UK during the COVID -19 Pandemic times Standard cancer surgical and chemotherapy treatment requiring hospitalization or daily visit had to be suspended to reduce at the minimum the exposure of these vulnerable patients to the possible infection [2] . This thus creates a conundrum in the management of this cohort of patient in the COVID-19 era, as one must aim to prevent compromise to the standard of care while sensibly employing strategies to mitigate the acquisition of the COVID-19 virus in this highly vulnerable group. Our facility''s reorganization strategies involved creating a "COVID-19 free" centre by employing rigorous screening protocols of all patients undergoing surgery as well as development of virtual teams [5] . The establishment of a COVID-19 free environment has allowed for the maintenance of the high standard of care in breast cancer patients, a highly vulnerable group [1] . abstract: nan url: https://api.elsevier.com/content/article/pii/S1748681520304447 doi: 10.1016/j.bjps.2020.08.144 id: cord-270294-g95skuik author: Johnstone, Jennie title: Viral Infection in Adults Hospitalized With Community-Acquired Pneumonia Prevalence, Pathogens, and Presentation date: 2008-12-31 words: 4441.0 sentences: 202.0 pages: flesch: 43.0 cache: ./cache/cord-270294-g95skuik.txt txt: ./txt/cord-270294-g95skuik.txt summary: Furthermore, viral etiology studies in pneumonia are difficult to interpret as noninvasive viral detection methods are often considered to be only markers of infection rather than the cause of pneumonia." Clearly, much better knowledge of the potential role of respiratory viruses present in patients with pneumonia is needed. More recently, the introduction of highly sensitive nucleic acid amplification tests (NATs) has dramatically improved our ability to detect multiple viral pathogens such as influenza, respiratory syncytial virus (RSV), rhinovirus, parainfluenza, and adenovirus. [13] [14] [15] To date, there have been few studies, 5, 7, [9] [10] [11] 16 ,17 reported in patients with pneumonia using NATs to detect viral infection, and these studies have either not included clinical data 7.9.11 or have not tested for all potentially important respiratory viruses in a comprehensive manner.lv-!? abstract: Background The potential role of respiratory viruses in the natural history of community-acquired pneumonia (CAP) in adults has not been well described since the advent of nucleic amplification tests (NATs). Methods From 2004 to 2006, adults with CAP who were admitted to five hospitals were prospectively enrolled in the study, and clinical data, cultures, serology, and nasopharyngeal swabs were obtained. NATs from swabs were tested for influenza, human metapneumovirus (hMPV), respiratory syncytial virus (RSV), rhinovirus, parainfluenza virus 1–4, coronaviruses (OC43, 229E, and NL63), and adenovirus. Results A total of 193 patients were included; the median age was 71 years, 51% of patients were male, and 47% of patients had severe CAP. Overall, 75 patients (39%) had a pathogen identified. Of these pathogens, 29 were viruses (15%), 38 were bacteria (20%), 8 were mixed (4%), and the rest were “unknown.” Influenza (n = 7), hMPV (n = 7), and RSV (n = 5) accounted for most viral infections; other infections included rhinovirus (n = 4), parainfluenza (n = 3), coronavirus (n = 4), and adenovirus (n = 2). Streptococcus pneumoniae was the most common bacterial infection (37%). Compared with bacterial infection, patients with viral infection were older (76 vs 64 years, respectively; p = 0.01), were more likely to have cardiac disease (66% vs 32%, respectively; p = 0.006), and were more frail (eg, 48% with limited ambulation vs 21% of bacterial infections; p = 0.02). There were few clinically meaningful differences in presentation and no differences in outcomes according to the presence or absence of viral infection. Conclusions Viral infections are common in adults with pneumonia. Easily transmissible viruses such as influenza, hMPV, and RSV were the most common, raising concerns about infection control. Routine testing for respiratory viruses may be warranted for adults who have been hospitalized with pneumonia. url: https://doi.org/10.1378/chest.08-0888 doi: 10.1378/chest.08-0888 id: cord-257781-ybpliz32 author: Jones, Eben title: Subcutaneous Emphysema, Pneumomediastinum, and Pneumothorax in Critically Ill Patients With Coronavirus Disease 2019: A Retrospective Cohort Study date: 2020-09-17 words: 3472.0 sentences: 190.0 pages: flesch: 44.0 cache: ./cache/cord-257781-ybpliz32.txt txt: ./txt/cord-257781-ybpliz32.txt summary: IMPORTANCE: Management of severe coronavirus disease 2019 relies on advanced respiratory support modalities including invasive mechanical ventilation, continuous positive airway pressure, and noninvasive ventilation, all of which are associated with the development of subcutaneous emphysema, pneumomediastinum, and pneumothorax (herein collectively termed barotrauma). Barotrauma cases had longer illness duration prior to critical care admission (10 vs 7 d; interquartile range, 8–14 and 6–10, respectively; p = 0.073) and were more often treated with continuous positive airway pressure or noninvasive ventilation as the initial modality of advanced respiratory support (87.5% vs 36.0%; p = 0.007). Subcutaneous emphysema, pneumomediastinum, and pneumothorax-herein collectively termed "barotrauma" (referring to the manifestation, rather than etiologic mechanism, of airway tract damage and resultant extra-alveolar air)-are known complications of all forms of positive pressure respiratory support and are associated with multiple organ failure and death (6) . abstract: IMPORTANCE: Management of severe coronavirus disease 2019 relies on advanced respiratory support modalities including invasive mechanical ventilation, continuous positive airway pressure, and noninvasive ventilation, all of which are associated with the development of subcutaneous emphysema, pneumomediastinum, and pneumothorax (herein collectively termed barotrauma). OBJECTIVES: To assess the occurrence rate of barotrauma in severe coronavirus disease 2019 and to explore possible associated factors. DESIGN, SETTING, AND PARTICIPANTS: A retrospective, single-center cohort study with nested case series, conducted at University Hospital Lewisham: a 450-bed general hospital in London, United Kingdom. All patients with confirmed coronavirus disease 2019 admitted to the critical care department from March 12, to April 12, 2020, were included. MAIN OUTCOMES AND MEASURES: Patients were retrospectively screened for radiological evidence of barotrauma. Admission characteristics, modalities of respiratory support, and outcomes were compared between barotrauma and nonbarotrauma groups. Respiratory parameters in the period preceding barotrauma identification were recorded. RESULTS: Of 83 admissions with coronavirus disease 2019, eight suffered barotrauma (occurrence rate 9.6%; 95% CI 4.3%–18.1%). Barotrauma cases had longer illness duration prior to critical care admission (10 vs 7 d; interquartile range, 8–14 and 6–10, respectively; p = 0.073) and were more often treated with continuous positive airway pressure or noninvasive ventilation as the initial modality of advanced respiratory support (87.5% vs 36.0%; p = 0.007). Patients managed with continuous positive airway pressure or noninvasive ventilation prior to the development of barotrauma had median minute ventilation of 16.2–19.9 and 21.3–22.7 L/min, respectively. Compared with the nonbarotrauma group, a higher proportion of patients with barotrauma had died (62.5% vs 43.2%), and a lower proportion of patients had been discharged (25.0% vs 53.3%) at 3-month follow-up. CONCLUSIONS AND RELEVANCE: Barotrauma appears to be a common complication of severe coronavirus disease 2019. Determining whether high minute ventilation while using continuous positive airway pressure or noninvasive ventilation predisposes patients to barotrauma requires further investigation. url: https://doi.org/10.1097/cce.0000000000000210 doi: 10.1097/cce.0000000000000210 id: cord-281344-iswbgqqe author: Jonker, Leonie T. title: Perioperative telemonitoring of older adults with cancer: Can we connect them all? date: 2020-09-04 words: 3935.0 sentences: 186.0 pages: flesch: 37.0 cache: ./cache/cord-281344-iswbgqqe.txt txt: ./txt/cord-281344-iswbgqqe.txt summary: MATERIAL AND METHODS: This is a retrospective analysis of a prospective cohort study with older patients (≥ 65 years) undergoing cancer-related surgery, who were identified for a perioperative telemonitoring study. This study is a retrospective analysis of a prospective cohort study with older patients undergoing cancer-related surgery, who were identified for a perioperative telemonitoring study (Netherlands trial registration number: NL 8253) [19] . The twelve patients who were discharged to an SNF were significantly older (mean age 79.0 versus 73.6 years old [p = 0.01]), had a higher ASA classification (ASA 3-4 58% versus 29% [p = 0.05]), used more medication (% polypharmacy 92% versus 50% [p = 0.00]) and were more often living alone or in a nursing home before surgery (50% versus 30%, 17% versus 0% [p = 0.00]). The main barriers to older adults'' participation in a perioperative telemonitoring study were lack of internet access at home, digital illiteracy, and a perceived high mental burden. abstract: OBJECTIVES: Although the increasing cancer incidence in older patients is widely recognised, older patients remain underrepresented in clinical cancer trials and eHealth studies. The aim of this research is to identify technological and patient-related barriers to inclusion of this population in a clinical eHealth study. MATERIAL AND METHODS: This is a retrospective analysis of a prospective cohort study with older patients (≥ 65 years) undergoing cancer-related surgery, who were identified for a perioperative telemonitoring study. Reasons for ineligibility and refusal had been prospectively registered. Characteristics and postoperative outcomes were compared between participants and non-participants. RESULTS: Between May 2018 and March 2020, 151 patients were assessed for eligibility, resulting in 65 participants and 86 non-participants. The main reason for ineligibility was lack of internet access at home (n = 16), while main reasons for refusal were perceived high mental burden (n = 46) and insufficient digital skills (n = 12). Compared with participants, non-participants were significantly older (mean age 75 vs. 73, p = 0.01); more often female (64% vs. 35%, p = 0.00), unmarried (42% vs. 8%, p = 0.01) living alone (38% vs. 19%, p = 0.02); had a higher ASA classification (43% vs. 19%, p = 0.00); often had polypharmacy (67% vs. 43%, p = 0.00); and were more often discharged to skilled nursing facilities (0% vs. 15%, p = 0.00). CONCLUSION: Our results confirm the underrepresentation of older female patients with little support from a partner and higher comorbidity. We should be aware of technological and patient-related barriers to including older adults with cancer, in order to avoid further dividing patients with low and high digital health literacy. url: https://api.elsevier.com/content/article/pii/S1879406820304227 doi: 10.1016/j.jgo.2020.08.008 id: cord-308907-elz62jlg author: Joob, Beuy title: 2019 Novel coronavirus and awareness date: 2020-05-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32217986/ doi: 10.1097/jcma.0000000000000306 id: cord-271944-oxtus5vb author: Joseph, Rudman title: Seizure And COVID-19: Association and Review of Potential Mechanism date: 2020-10-13 words: 2360.0 sentences: 166.0 pages: flesch: 48.0 cache: ./cache/cord-271944-oxtus5vb.txt txt: ./txt/cord-271944-oxtus5vb.txt summary: Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, this highly transmissible virus has since spread rapidly around the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a novel coronavirus that causes Coronavirus Disease of 2019 (COVID19) , a disease that can present with a variety of symptoms [1] . The most common symptoms at the onset of COVID-19 illness are fever, cough, and fatigue; in severe cases, patients may develop severe pneumonia, acute respiratory distress syndrome, and organ failure [4] . This article presents a review of the current literature on seizures linked with SARS-COV 2 infection and describes possible underlying mechanisms. describes the demographic data, time to onset of neurological symptoms, diagnostic criteria, intervention, and outcomes from 11 studies of seizures associated with SARS-COV-2 infection. abstract: Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, this highly transmissible virus has since spread rapidly around the world. Though respiratory complication is the primarily reported manifestation though rare, yet serious neurological complications are being frequently reported in the literature. In selected coronavirus disease-2019 (COVID-19) cases neurologic complications may manifest as seizures. In this paper, we have reviewed current literature on seizures linked with SARS- COV 2 infection including published or pre-print original articles, review articles, and case reports. We have discussed the electroencephalogram (EEG), imaging, and Cerebrospinal fluid (CSF) findings in COVID-19 patients presenting with seizure. We will be concluding the paper by briefly discussing the three possible seizure development mechanisms in patients infected with SARS- COV 2, which includes - (a) Direct Mechanism (b) Indirect Mechanism and (c) Exacerbation of Seizure in Patients with Epilepsy (PWE). Our aim is to update the physicians working with COVID-19 patients about this potential complication and hope that understanding of these proposed mechanisms can provide an opportunity for the physicians for early diagnosis or even better, help prevent this complication. url: https://www.ncbi.nlm.nih.gov/pubmed/33071468/ doi: 10.1016/j.npbr.2020.10.001 id: cord-292826-lus0tqmi author: Joseph, Tony title: Trauma care in a low-COVID pandemic environment: A new normal date: 2020-06-12 words: 1267.0 sentences: 60.0 pages: flesch: 46.0 cache: ./cache/cord-292826-lus0tqmi.txt txt: ./txt/cord-292826-lus0tqmi.txt summary: Injury 51 (2020) [1245] [1246] Contents lists available at ScienceDirect Injury journal homepage: www.elsevier.com/locate/injury Editorial Trauma care in a low-COVID pandemic environment: A new normal A pandemic is defined as an outbreak of a disease that spreads quickly over a wide geographical area and infects a high proportion of a population. As we have seen with the current COVID-19 pandemic, some countries have managed to control spread early (eg Taiwan, Singapore, New Zealand and Australia) by immediate action involving physical distancing, widespread testing, contact tracing, isolation of positive cases and supportive treatment. Current recommendations [5] for the management of injured patients in a COVID-19 environment include bypassing the Emergency Department for uncomplicated injuries, minimising invasive procedures, in particular those that are AGPs, and providing surgical treatment that is only absolutely essential. Editorial / Injury 51 (2020) [1245] [1246] The COVID 19 pandemic presents challenges for trauma clinicians with the ongoing risk of virus transmission for both patients and clinical staff which will need to be managed over the coming months or longer. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32540094/ doi: 10.1016/j.injury.2020.05.041 id: cord-028557-68jypaaw author: Joshi, Jaiteerth R. title: COVSACK: an innovative portable isolated and safe COVID-19 sample collection kiosk with automatic disinfection date: 2020-07-05 words: 3791.0 sentences: 186.0 pages: flesch: 54.0 cache: ./cache/cord-028557-68jypaaw.txt txt: ./txt/cord-028557-68jypaaw.txt summary: The possible reasons for the virus transmission to the healthcare worker could be due to (1) lack of sufficient quantity of personal protective equipment (PPE) at the most infected places; (2) PPE provided not meeting the quality standard requirements; (3) inadequate or unsuitable isolation chambers for testing of suspected patients; and (4) prevailing unhygienic conditions in the facilities where COVID-19 positive patients are treated. The healthcare worker who is standing outside the chamber inserts his hands through the long cuff gloves and collects the sample from either nose or throat of COVID-19 patient. At the deployed hospital, the first prototype COVSACK unit stands to be highly effective in preventing the transmission of COVID-19 virus to healthcare workers during sample collection from suspected persons, due its in-built features such as air tightness, use of long cuff gloves and automatic disinfectant spraying followed by thorough water flushing after each patient exits the kiosk. abstract: The Corona VIrus Disease 2019 (COVID-19) is one of the significant medical disaster that changed the life of humankind in the 21st century. The deadly virus is transmittable from infected person, through his nasal droplets, to surrounding people among whom, the healthcare personnel are the utmost affected. The present article brings out an innovative chamber, which is used for collection of throat, or nasal swabs/samples for diagnosis of COVID-19 suspected persons. The chamber, called COVid SAmple Collection Kiosk (COVSACK), eliminates the transmission of the deadly virus to the health care personnel while collecting the sample. The kiosk is designed based on CFD simulations for effective spread of disinfectant in fine droplet form, built with a lightweight composite that is sustainable in extreme weather conditions and the kiosk can be easily sanitized within 3 min after sample collection. The chamber is first positioned in ESI Hospital, Hyderabad, and other hospitals and diagnostics centres across India, extensively being used for testing the COVID-19 patients at a faster rate, with a drastic reduction in use of personal protection equipment (PPE). This technological innovation, to certain extent, has changed the way the testing of COVID-19 patients carried out in the country. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335413/ doi: 10.1007/s41403-020-00139-1 id: cord-347064-ljd121no author: José, Ricardo J. title: Opportunistic bacterial, viral and fungal infections of the lung date: 2016-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Opportunistic infections are a major cause of morbidity and mortality in severely immunocompromised patients, such as those receiving chemotherapy or biological therapies, patients with haematological malignancy, aplastic anaemia or HIV infection, and recipients of solid-organ or stem cell transplants. The type and degree of the immune defect dictate the profile of potential opportunistic pathogens; T-cell-mediated defects increase the risk of viral (cytomegalovirus, respiratory viruses) and Pneumocystis jirovecii infections, whereas neutrophil defects are associated with bacterial pneumonia and invasive aspergillosis. However, patients often have combinations of immune defects, and a wide range of other opportunistic infections can cause pneumonia. Importantly, conventional non-opportunistic pathogens are frequently encountered in immunocompromised hosts and should not be overlooked. The radiological pattern of disease (best assessed by computed tomography) and speed of onset help to identify the likely pathogen(s); radiological imaging can subsequently be supported by targeted investigation including the early use of bronchoscopy in selected patients. Rapid and expert clinical assessment can identify the most likely pathogens, which can then be treated aggressively, providing the best opportunity for a positive clinical outcome. url: https://www.sciencedirect.com/science/article/pii/S1357303916300159 doi: 10.1016/j.mpmed.2016.03.015 id: cord-356195-5pcaxpp9 author: Jothimani, Dinesh title: COVID-19 and Liver. date: 2020-06-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The current pandemic coronavirus labelled as Severe Acute Respiratory Distress Syndrome Coronavirus -2 (SARS -CoV-2) is a significant public health threat over for past few weeks. Overall case fatality rates range between 2-6%; however, the rates are higher in patients with severe disease, advanced age and underlying comorbidities like diabetes, hypertension and heart disease. Recent reports showed about 2-11% of patients with COVID-19 had underlying chronic liver disease. Experience from previous SARS epidemic suggest that 60% of patients developed various degrees of liver damage. In the current pandemic, hepatic dysfunction was seen in 14-53% of patients with COVID-19, particularly in those with severe disease. Cases of acute liver injury have been reported, associated with higher mortality. Hepatic involvement in COVID-19 could be multifactorial related to any of direct cytopathic effect of the virus, uncontrolled immune reaction, sepsis or drug induced liver injury. The postulated mechanism of viral entry is through the host ACE2 receptors that are abundantly present in type 2 alveolar cells. Interestingly, the expression of ACE2 receptors were identified in the gastrointestinal tract, vascular endothelium and cholangiocytes of the liver. Liver transplant recipients with COVID-19 have been reported recently. Effects of COVID-19 on underlying chronic liver disease requires a detailed evaluation and currently data is lacking and further research is warranted in this area. With lack of definitive therapy, patient education, hand hygiene and social distancing appears to be the cornerstone in minimising the disease spread. url: https://api.elsevier.com/content/article/pii/S0168827820303779 doi: 10.1016/j.jhep.2020.06.006 id: cord-291687-kwu0otpi author: Judson, Gregory L. title: Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection date: 2020-06-13 words: 5569.0 sentences: 273.0 pages: flesch: 40.0 cache: ./cache/cord-291687-kwu0otpi.txt txt: ./txt/cord-291687-kwu0otpi.txt summary: A review of 44,672 confirmed COVID-19 cases from Wuhan, China, demonstrated increased mortality in patients with cardiovascular disease (10.5%), diabetes (7.3%), and hypertension (6%), which was significantly higher than the overall case-fatality rate of 2.3% [22] . These initial cases series have shown a similar relationship between underlying cardiac comorbidities with a higher prevalence of hypertension, diabetes, coronary artery disease, and obesity in patients requiring mechanical ventilation [24] . Early studies reported a prevalence of acute cardiac injury of 12% in the entire cohort as defined by either high sensitivity troponin (Hs Tn) or the MB fraction of creatinine kinase (CK-MB) [ 99 th percentile or new echocardiographic or electrocardiographic abnormalities with greater elevations in cardiac biomarkers among patients requiring ICU care [1, 20] . Case cohort studies included data in patients for whom the outcome and illness course helped further elucidate the role of cardiac injury in COVID-19 disease. abstract: The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has profoundly impacted all fields of medicine. Infection with SARS-CoV-2 and the resulting coronavirus of 2019 (COVID-19) syndrome has multiorgan effects. The pandemic has united researchers from bench to bedside in attempts to understand the pathophysiology of the disease and define optimal treatment strategies. Cardiovascular disease is highly prevalent and a leading cause of death across gender, race, and ethnic groups. As the pandemic spreads, there is increasing concern about the cardiovascular effects of the viral infection and the interaction of infection with existing cardiovascular disease. Additionally, there are concerns about the cardiac effects of the numerous treatment agents under study. It will be essential for cardiologists to understand the interplay between underlying cardiac comorbidities, acute cardiovascular effects of COVID-19 disease, and adverse effects of new treatments. Here we describe emerging evidence of the epidemiology of SARS-CoV-2 infection and underlying cardiovascular disease, the evidence for direct myocardial injury in SARS-CoV-2 infection, the specific presentations of cardiovascular involvement by SARS-CoV-2, and the cardiac effects of emerging treatments. url: https://doi.org/10.1007/s40119-020-00184-5 doi: 10.1007/s40119-020-00184-5 id: cord-273119-jfy0iviy author: Julka-Anderson, Naman title: How COVID-19 is testing and evolving our communication skills date: 2020-06-25 words: 2275.0 sentences: 137.0 pages: flesch: 68.0 cache: ./cache/cord-273119-jfy0iviy.txt txt: ./txt/cord-273119-jfy0iviy.txt summary: In UK radiotherapy departments, radiation therapist (review radiographer)-led clinics moved to telephone-based clinics to reduce the time spent by patients in a hospital environment. The pandemic has forced patients to slow down and really focus on themselves which has led to picking up physical and mental health changes earlier. As a radiation therapist (therapeutic radiographer) and member of the radiotherapy review team, I see patients throughout their radiotherapy treatments to address their physical and emotional side effects. Those of us in the radiotherapy review team have changed to telephone appointments to minimize time spent by patients in a hospital environment. Telephone reviews aren''t a new process within healthcare (4); oncology teams use telephone triage when patients report treatment related side effects. In my opinion, radiotherapy reviews are more in depth than triage calls as they cover all aspects of a patient''s care and side effects to help them live with and beyond cancer. abstract: The COVID-19 pandemic forced us, as health care professionals and members of the general public, to adapt. Simple things we take for granted have become more difficult. As pressures increased for health care professionals, conversations and decisions have become tougher. This brought the need to adapt working practices and find ways to continue providing compassionate patient-centred care remotely. In UK radiotherapy departments, radiation therapist (review radiographer)-led clinics moved to telephone-based clinics to reduce the time spent by patients in a hospital environment. This required setting up a "virtual" clinic room with patients by removing distractions and setting boundaries for the conversation. We have had to adapt our communication skills quickly as picking up on nonverbal cues is not possible through the phone. It can be challenging to understand feelings through the tone of a patient's voice and empathise accordingly. The pandemic has forced patients to slow down and really focus on themselves which has led to picking up physical and mental health changes earlier. This is one of the many positive outcomes that can be drawn from the pandemic. Although we have changed how we work, ultimately we are still here to help our patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32709543/ doi: 10.1016/j.jmir.2020.06.008 id: cord-292315-7vwybku8 author: Jung, Gyuwon title: Too Much Information: Assessing Privacy Risks of Contact Trace Data Disclosure on People With COVID-19 in South Korea date: 2020-06-18 words: 7867.0 sentences: 373.0 pages: flesch: 51.0 cache: ./cache/cord-292315-7vwybku8.txt txt: ./txt/cord-292315-7vwybku8.txt summary: Then, an ordinal scale of relative privacy risk levels was introduced for evaluation, and the assessment was performed on the personal information included in the contact trace data, such as demographics, significant places, sensitive information, social relationships, and routine behaviors. As shown in Table 2 , the released contact trace data included (1) the patient''s demographics (i.e., nationality, gender, age, and residence), (2) infection information (i.e., infection route and confirmation date), and (3) travel log in time series (e.g., transport modes and visited places). The codebook has an ordinal scale of privacy risk levels and the scale quantifies relative risks from five major categories: demographics (nationality, gender, age), significant places (residence, workplace), sensitive information (hobby, religion, accommodation), social relationships, and routine behavior. In particular, the data from Sejong revealed the most detailed information on significant places (the average privacy risk levels for residence and workplace in Sejong were over level 3), whereas Ulsan showed a relatively high percentage of data disclosure on social relationships (i.e., 72.4% of the confirmed patients in Ulsan). abstract: Introduction: With the COVID-19 outbreak, South Korea has been making contact trace data public to help people self-check if they have been in contact with a person infected with the coronavirus. Despite its benefits in suppressing the spread of the virus, publicizing contact trace data raises concerns about individuals' privacy. In view of this tug-of-war between one's privacy and public safety, this work aims to deepen the understanding of privacy risks of contact trace data disclosure practices in South Korea. Method: In this study, publicly available contact trace data of 970 confirmed patients were collected from seven metropolitan cities in South Korea (20th Jan–20th Apr 2020). Then, an ordinal scale of relative privacy risk levels was introduced for evaluation, and the assessment was performed on the personal information included in the contact trace data, such as demographics, significant places, sensitive information, social relationships, and routine behaviors. In addition, variance of privacy risk levels was examined across regions and over time to check for differences in policy implementation. Results: It was found that most of the contact trace data showed the gender and age of the patients. In addition, it disclosed significant places (home/work) ranging across different levels of privacy risks in over 70% of the cases. Inference on sensitive information (hobby, religion) was made possible, and 48.7% of the cases exposed the patient's social relationships. In terms of regional differences, a considerable discrepancy was found in the privacy risk for each category. Despite the recent release of government guidelines on data disclosure, its effects were still limited to a few factors (e.g., workplaces, routine behaviors). Discussion: Privacy risk assessment showed evidence of superfluous information disclosure in the current practice. This study discusses the role of “identifiability” in contact tracing to provide new directions for minimizing disclosure of privacy infringing information. Analysis of real-world data can offer potential stakeholders, such as researchers, service developers, and government officials with practical protocols/guidelines in publicizing information of patients and design implications for future systems (e.g., automatic privacy sensitivity checking) to strike a balance between one's privacy and the public benefits with data disclosure. url: https://doi.org/10.3389/fpubh.2020.00305 doi: 10.3389/fpubh.2020.00305 id: cord-320877-1i0hzfjk author: KIYKAÇ ALTINBAŞ, Şadıman title: Gynecological laparoscopic surgery in the shade of COVID-19 pandemic date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A global public health problem with a high rate spread and transmission, Coronavirus outbreak has become the most talked-about matter throughout the world. We are severely affected by the nations with vast numbers of deaths; it was hard to predict such a colossal pandemic with terrifying consequences. Elective surgeries are limited, but situations requiring an urgent gynaecological or obstetric surgical approach must still be performed during the COVID-19 pandemic. Concerns regarding surgical safety and the risk of viral transmission during surgery are of great importance. In this review, we aimed to summarize the concepts related to laparoscopic gynecological surgery during COVID-19 pandemic in the light of current literature. url: https://doi.org/10.3906/sag-2004-272 doi: 10.3906/sag-2004-272 id: cord-327415-nu1msnui author: Kadiane-Oussou, N’dri Juliette title: COVID-19: comparative clinical features and outcome in 114 patients with or without pneumonia (Nord Franche-Comte Hospital, France) date: 2020-10-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 patients (n=114) were included (55 patients with pneumonia (group P) and 59 without pneumonia (group NP). Patients in group P were older (69 (±17) years vs 46 (±16); p<0.001) with a male predominance (58.2% vs 27.1%; p<0.001). The symptoms which were statistically more frequents in patients with pneumonia were fever ≥ 38°C (93% vs 70%; p=0.002) and dyspnea (73% vs 22%; p<0.001). Symptoms such as facial headache (42% vs 15%; p=0.001), sore throat (39% vs 16%; p=0.007), dysgeusia (61% vs 33%; p=0.003), anosmia (63% vs 31%; p=0.001) were statistically more frequents in patients without pneumonia. url: https://doi.org/10.1016/j.micinf.2020.10.002 doi: 10.1016/j.micinf.2020.10.002 id: cord-343437-cz1w9od9 author: Kahaly, George J title: Management of Graves‘Thyroidal And Extrathyroidal Disease – An Update date: 2020-09-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: CONTEXT: Invited update on the management of systemic autoimmune Graves ‘disease (GD) and associated orbitopathy (GO) EVIDENCE ACQUISITION: Guidelines, pertinent original articles, systemic reviews, and meta-analyses. EVIDENCE SYNTHESIS: Thyrotropin receptor antibodies (TSH-R-Ab), foremost the stimulatory TSH-R-Ab, are a specific biomarker for GD. Their measurement assists in the differential diagnosis of hyperthyroidism and offers accurate and rapid diagnosis of GD. Thyroid ultrasound is a sensitive imaging tool for GD. Worldwide, thionamides are the favored treatment (12-18 months) of newly diagnosed GD with Methimazole (MMI) as the preferred drug. Patients with persistently high TSH-R-Ab and/or persistent hyperthyroidism at 18 months, or with a relapse after completing a course of MMI, can opt for a definitive therapy with radioactive iodine (RAI) or total thyroidectomy (TX). Continued long-term, low-dose MMI administration is a valuable and safe alternative. Patient choice, both at initial presentation of GD and at recurrence, should be emphasized. Propylthiouracil is preferred to MMI during the first trimester of pregnancy. TX is best performed by a high-volume thyroid surgeon. RAI should be avoided in GD patients with active GO, especially in smokers. Recently, a promising therapy with an anti-insulin-like growth factor-1 monoclonal antibody for patients with active/severe GO was FDA-approved. COVID-19 infection is a risk factor for poorly controlled hyperthyroidism, which contributes to the infection-related mortality risk. If GO is not severe, systemic steroid treatment should be postponed during COVID-19 while local treatment and preventive measures are offered. CONCLUSIONS: A clear trend towards serological diagnosis and medical treatment of GD has emerged. url: https://doi.org/10.1210/clinem/dgaa646 doi: 10.1210/clinem/dgaa646 id: cord-320892-dcfi5u04 author: Kaidi, Austin C. title: Timing and Tips for Total Hip Arthroplasty in a Critically Ill COVID-19 Patient with a Femoral Neck Fracture: A Case Report date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Expedited time to surgery following hip fracture is associated with decreased morbidity and mortality in appropriately optimized patients. However, the optimal timing of surgery in patients with novel coronavirus disease 2019 (COVID-19) infection remains unknown. This case report describes a patient with COVID-19 pneumonia complicated by multi-organ system failure requiring intubation who sustained a femoral neck fracture that required total hip arthroplasty (THA). This patient had a significant, deliberate delay in time to surgical intervention due to his critical state. When deciding the optimal timing for THA in COVID-19 patients we recommend utilizing inflammatory markers, such as procalcitonin and IL-6, as indicators of disease resolution and caution operative intervention when patients are nearing the 7-10(th) day of COVID-19 symptoms. Furthermore, implant cementation and spinal anesthesia in critically ill COVID-positive patients should be approached cautiously in the setting of pulmonary disease and multi-organ system failure. Close follow-up with medical doctors is recommended to minimize long-term sequelae and delay to baseline mobility. url: https://www.ncbi.nlm.nih.gov/pubmed/32802926/ doi: 10.1016/j.artd.2020.07.006 id: cord-260700-u12aa739 author: Kainulainen, Leena title: Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia date: 2010-06-10 words: 3686.0 sentences: 248.0 pages: flesch: 46.0 cache: ./cache/cord-260700-u12aa739.txt txt: ./txt/cord-260700-u12aa739.txt summary: title: Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia OBJECTIVE: We conducted a prospective 12-month follow-up study of respiratory tract infections in 12 adult patients with primary hypogammaglobulinemia. METHODS: Nasal swab samples and induced sputum samples were taken at the onset of acute respiratory tract infection and every 3 months thereafter. CONCLUSIONS: Despite adequate immunoglobulin replacement therapy, patients with primary hypogammaglobulinemia have increased susceptibility to respiratory tract viral infections. Using modern diagnostic techniques, we wanted to study the occurrence of respiratory tract infections, especially viral infections, in patients with primary hypogammaglobulinemia who were receiving regular immunoglobulin replacement therapy. If the spouse of the patient had acute symptoms of respiratory tract infection, she or he took nasal swabs at home according to the instructions of the research nurse and sent the vials by post. First, despite adequate immunoglobulin replacement therapy, most patients with primary hypogammaglobulinemia had increased susceptibility to respiratory tract viral infections. abstract: BACKGROUND: The occurrence of respiratory tract viral infections in patients with primary hypogammaglobulinemia has not been studied. OBJECTIVE: We conducted a prospective 12-month follow-up study of respiratory tract infections in 12 adult patients with primary hypogammaglobulinemia. METHODS: Nasal swab samples and induced sputum samples were taken at the onset of acute respiratory tract infection and every 3 months thereafter. Samples were tested for bacteria and viruses. PCR tests were performed for 15 respiratory tract viruses. In case the results for rhinovirus were positive, follow-up nasal swab samples were taken every 2 weeks until rhinoviral PCR results became negative. Patients completed symptom diaries, which were collected every month. The spouses of the patients served as healthy control subjects. RESULTS: During the 12-month period, the 12 patients had 65 episodes of acute respiratory tract infections, and the 11 spouses had 12 acute episodes (P < .001). Respiratory tract viruses were found in sputum in 54% of the infections. Rhinovirus was the most common virus. In more than half of our patients, rhinoviral PCR results stayed positive for more than 2 months. The most long-acting persistence with the same rhinovirus was 4 months. CONCLUSIONS: Despite adequate immunoglobulin replacement therapy, patients with primary hypogammaglobulinemia have increased susceptibility to respiratory tract viral infections. Rhinoviral infections are frequent and prolonged. url: https://api.elsevier.com/content/article/pii/S0091674910006652 doi: 10.1016/j.jaci.2010.04.016 id: cord-252085-8dq3gdo8 author: Kaisy, Dr. Maythem Abdulhassan Al title: Chest Drain Insertion following Pneumothorax due to CPR in a COVID – 19 Patient. date: 2020-08-14 words: 1157.0 sentences: 77.0 pages: flesch: 50.0 cache: ./cache/cord-252085-8dq3gdo8.txt txt: ./txt/cord-252085-8dq3gdo8.txt summary: title: Chest Drain Insertion following Pneumothorax due to CPR in a COVID – 19 Patient. Chest Drain Insertion following Pneumothorax due to CPR in a COVID -19 Patient. Thus, in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection lungs are fragile and especially those with positive pressure ventilations, the dangers of pneumothorax arise, and comprehensive management is warranted. A 42 years old male patient was transferred to our hospital, intubated on mechanical ventilation, he had a 1 week history of fever, cough and shortness of breath, with positive PCR test for COVID-19, and CT scan showing extensive bilateral multiple, multilobed ground glass appearance with areas of consolidation, there was no given history of previous lung diseases or smoking history ( Figure 1 ). A portable chest x-ray was ordered, and the patient was found to have significant amount of left sided -pneumothorax with underlying lung collapse , mild mediastinal shift to the right side, with progressive course regarding the right side opacities (Figure 2 ), compared to previous x-ray. abstract: nan url: https://api.elsevier.com/content/article/pii/S2405469020301515 doi: 10.1016/j.visj.2020.100862 id: cord-013105-tmhce7p5 author: Kalil, Andre C. title: Less is more: critically ill status is not a carte blanche for unlimited antibiotic use date: 2020-10-09 words: 1496.0 sentences: 66.0 pages: flesch: 28.0 cache: ./cache/cord-013105-tmhce7p5.txt txt: ./txt/cord-013105-tmhce7p5.txt summary: In addition, we propose that health-care providers can bring concrete and direct benefits to each of our critically ill patients at the bedside by preventing the excessive use of unnecessary antibiotics. The clinical deterioration of mechanically ventilated patients may be associated with a new infection process; however, the majority of ventilator-associated events leading to antibiotic administration is related to noninfectious processes [6] ; thus, the appropriate antimicrobial de-escalation is essential and can be safely done if culture results are negative [7, 8] . For many decades, critically ill patients have been treated with antibiotics during two to three weeks for severe infections including pneumonias, abdominal and urinary infections, all of which still comprise the majority of infections leading to sepsis and admission to the intensive care unit. Effect of aminoglycoside and beta-lactam combination therapy versus beta-lactam monotherapy on the emergence of antimicrobial resistance: a meta-analysis of randomized, controlled trials abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545809/ doi: 10.1007/s00134-020-06260-7 id: cord-252751-prock3co author: Kalligeros, Markos title: Remdesivir Use Compared to Supportive Care in Hospitalized Patients with Severe COVID-19: A Single-Center Experience date: 2020-08-06 words: 3948.0 sentences: 238.0 pages: flesch: 55.0 cache: ./cache/cord-252751-prock3co.txt txt: ./txt/cord-252751-prock3co.txt summary: To be considered eligible for trial inclusion, patients had to meet the following criteria: 1) Currently hospitalized, aged ≥ 18 years, 2) SARS-CoV-2 infection confirmed by PCR test ≤ 4 days before trial enrollment 3) SpO2 ≤ 94% on room air or requiring supplemental oxygen at screening 4) Presence of radiographic evidence of pulmonary infiltrates. For each patient we extracted the following information: age, sex, race, ethnicity, days from onset of symptoms, imaging results, weight, vital signs and laboratory values (both on admission and during hospitalization), preexisting medical conditions, admission to the intensive care unit (ICU), use of mechanical ventilation, use of systemic corticosteroids [12] , hospitalization outcome (death or discharge) and incidence of acute kidney injury (AKI) using the KDIGO criteria [13] . In order to provide a cohesive assessment of the efficacy of remdesivir, we compared the clinical outcomes of patients who were hospitalized with severe COVID-19 (requiring supplemental oxygen and having abnormal imaging findings) and received either remdesivir or supportive care. abstract: BACKGROUND: The US Food and Drug Administration issued an Emergency Use Authorization for remdesivir use in patients with severe COVID-19. METHODS: We utilized data from two quaternary, acute care hospitals. The outcomes of interest were the impact of remdesivir on in-hospital death by day 28 as well as time to recovery, clinical improvement, and discharge. We utilized Cox proportional hazards models and stratified log-rank tests. RESULTS: 224 patients were included in the study. Median age was 59 years; 67.0% were male; 17/125 patients (13.6%) who received supportive care and 7/99 patients (7.1%) who received remdesivir died. The unadjusted risk for 28-day in-hospital death was lower for patients who received remdesivir compared to patients who received supportive care (HR 0.42; 95% CI: 0.16-1.08). Although this trend remained the same after adjusting for age, sex, race and oxygen requirements on admission (aHR 0.49; 95% CI: 0.19-1.28), as well as chronic comorbidities and use of corticosteroids (aHR 0.44; 95% CI: 0.16-1.23), it did not reach statistical significance. The use of remdesivir was not associated with an increased risk of acute kidney injury (AKI) and liver test abnormalities. Although not statistically significant, the rate ratios for time to recovery, clinical improvement, and discharge were higher in women and Black or African American patients. CONCLUSION: Patients on remdesivir had lower, albeit not significant, all-cause in hospital mortality, and the use of remdesivir did not increase the risk for AKI. Promising signals from this study need to be confirmed by future placebo-controlled randomized clinical trials. url: https://doi.org/10.1093/ofid/ofaa319 doi: 10.1093/ofid/ofaa319 id: cord-288509-l6yn2er7 author: Kalu, Peter title: The rules for online clinical engagement in the COVID era date: 2020-08-22 words: 3025.0 sentences: 165.0 pages: flesch: 49.0 cache: ./cache/cord-288509-l6yn2er7.txt txt: ./txt/cord-288509-l6yn2er7.txt summary: As a result, even in the absence of a good evidence base, online video consultation platforms such as Attend Anywhere have been implemented across secondary care, with a national licence for NHS trusts from April 2020. 2 In this paper we review current technical, medical and legal guidelines for video consulting to assist hospital doctors who are conducting remote consultations as a result of COVID-19. Although observational studies and randomised control trials of video consultation in primary, secondary and tertiary care generally report a positive patient and clinician experience with remote consultation technology 8, 10, [16] [17] [18] [19] , studies of specific platforms are limited. Evidence regarding the use of telemedicine in secondary care is currently limited but is likely to grow in the post-COVID era as organisations such as the GMC are already conducting surveys of remote consultation and prescribing. abstract: COVID-19 has generated a need to rapidly increase online consulting in secondary care, an area in which it has previously been underutilised. We sought to review the guidance around conducting remote consultations and found that while there is a large amount of information about the implementation of remote consultations at an organisation level, there is a paucity of high-quality papers considering the guidelines for online consultations alongside practical advice for their implementation at the individual level. We reviewed guidelines from reputable medical sources and generated practical advice to assist practitioners in performing safe and effective video consultation. Additionally, we noted reports in the literature of a lack of transparency and resulting confusion regarding the choice of telemedicine platforms. We therefore sought to summarise key characteristics of a number of major telemedicine platforms. We recognised a lack of clarity regarding the legal status of performing remote consultations, and reviewed advice from medicolegal sources. Finally, we address the sources of these individual uncertainties, and give recommendations on how these might be addressed systematically, so the practitioners are well trained and competent in the use of online consultations, which will inevitably play an increasingly large role in both primary and secondary care settings in the future. url: https://doi.org/10.1016/j.bjps.2020.08.045 doi: 10.1016/j.bjps.2020.08.045 id: cord-263530-t9ryky6f author: Kamal, Yasmine Mohamed title: Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully date: 2020-09-16 words: 2480.0 sentences: 158.0 pages: flesch: 45.0 cache: ./cache/cord-263530-t9ryky6f.txt txt: ./txt/cord-263530-t9ryky6f.txt summary: ► Abdominal CT was normal ► Brain MRI with contrast, performed after 2 weeks to comply with our hospital''s protocol that only allows COVID-19-negative patient to get in contact with the MRI machine, revealed abnormal signal intensity in the temporal lobe cortex bilaterally in a rather symmetrical fashion. Seven hundred and fifty milligrams of intravenous acyclovir sodium, three times per day, was started empirically before the cerebrospinal fluid (CSF) results were obtained, addressing the possibility of herpes simplex virus (HSV) I and II encephalitis. The early suspicion of COVID-19 encephalitis and performing the appropriate CSF studies was the key to establishing the correct diagnosis and timely management. ► A red flag of the possibility of COVID-19 encephalitis should be raised whenever patients present with abnormal behaviour, acute psychosis, confusion state or drowsiness. abstract: The COVID-19 pandemic that attracted global attention in December 2019 is well known for its clinical picture that is consistent with respiratory symptoms. Currently, the available medical literature describing the neurological complications of COVID-19 is gradually emerging. We hereby describe a case of a 31-year-old COVID-19-positive patient who was admitted on emergency basis. His clinical presentation was primarily neurological, rather than the COVID-19’s classical respiratory manifestations. He presented with acute behavioural changes, severe confusion and drowsiness. The cerebrospinal fluid analysis was consistent with COVID-19 encephalitis, as well as the brain imaging. This experience confirms that neurological manifestations might be expected in COVID-19 infections, despite the absence of significant respiratory symptoms. Whenever certain red flags are raised, physicians who are involved in the management of COVID-19 should promptly consider the possibility of encephalitis. Early recognition of COVID-19 encephalitis and timely management may lead to a better outcome. url: https://www.ncbi.nlm.nih.gov/pubmed/32938656/ doi: 10.1136/bcr-2020-237378 id: cord-011159-k2kca8zl author: Kamel, Toufik title: Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study date: 2020-01-07 words: 5114.0 sentences: 230.0 pages: flesch: 46.0 cache: ./cache/cord-011159-k2kca8zl.txt txt: ./txt/cord-011159-k2kca8zl.txt summary: b Patient recruitment exceeded the 500 expected, because we anticipated a number of non-workable case report forms h More than one indication could be present for each BAL i Significantly higher than in the nasal high-flow oxygen therapy or non-invasive ventilation group (p < 0.001), and then in the invasive mechanical ventilation group (p = 0.001) j H0 indicates the time at which BAL has began k Experience in years in the specialty and in terms of number of BAL performed are detailed in Table S1 of the Online resource 1 l We defined the physician performing the BAL as an "experienced physician" when he/she was a pulmonologist or when he/she was an intensivist with the greatest experience (i.e., > 10 years in the specialty or > 50 BAL performed) 35-3.50 ]; p = 0.002) and the amount of BAL fluid (in ml) recovered handled as a linear predictor (OR 1.02 [1.01-1.03] per 1 ml increase; p < 0.01), were statistically significant predictors of a BAL fluid of good quality (Table S6 ). abstract: PURPOSE: To assess the benefit-to-risk balance of bronchoalveolar lavage (BAL) in intensive care unit (ICU) patients. METHODS: In 16 ICUs, we prospectively collected adverse events during or within 24 h after BAL and assessed the BAL input for decision making in consecutive adult patients. The occurrence of a clinical adverse event at least of grade 3, i.e., sufficiently severe to need therapeutic action(s), including modification(s) in respiratory support, defined poor BAL tolerance. The BAL input for decision making was declared satisfactory if it allowed to interrupt or initiate one or several treatments. RESULTS: We included 483 BAL in 483 patients [age 63 years (interquartile range (IQR) 53–72); female gender: 162 (33.5%); simplified acute physiology score II: 48 (IQR 37-61); immunosuppression 244 (50.5%)]. BAL was begun in non-intubated patients in 105 (21.7%) cases. Sixty-seven (13.9%) patients reached the grade 3 of adverse event or higher. Logistic regression showed that a BAL performed by a non-experienced physician (non-pulmonologist, or intensivist with less than 10 years in the specialty or less than 50 BAL performed) was the main predictor of poor BAL tolerance in non-intubated patients [OR: 3.57 (95% confidence interval 1.04–12.35); P = 0.04]. A satisfactory BAL input for decision making was observed in 227 (47.0%) cases and was not predictable using logistic regression. CONCLUSIONS: Adverse events related to BAL in ICU patients are not infrequent nor necessarily benign. Our findings call for an extreme caution, when envisaging a BAL in ICU patients and for a mandatory accompaniment of the less experienced physicians. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-019-05896-4) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223716/ doi: 10.1007/s00134-019-05896-4 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61068.0 sentences: 3463.0 pages: flesch: 49.0 cache: ./cache/cord-014538-6a2pviol.txt txt: ./txt/cord-014538-6a2pviol.txt summary: Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225389/ doi: 10.1186/s13613-016-0224-7 id: cord-347351-emdj66vj author: Kampf, Günter title: Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2 date: 2020-09-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: During the current SARS-CoV-2 pandemic new studies are emerging daily providing novel information about sources, transmission risks and possible prevention measures. In this review, we aimed to comprehensively summarize the current evidence on possible sources for SARS-CoV-2, including evaluation of transmission risks and effectiveness of applied prevention measures. Next to symptomatic patients, asymptomatic or pre-symptomatic carriers are a possible source with respiratory secretions as the most likely cause for viral transmission. Air and inanimate surfaces may be sources; however, viral RNA has been inconsistently detected. Similarly, even though SARS-CoV-2 RNA has been detected on or in personnel protective equipment, blood, urine, eyes, the gastrointestinal tract and pets, these sources are currently thought to play a negligible role for transmission. Finally, various prevention measures such as hand washing, hand disinfection, face masks, gloves, surface disinfection or physical distancing for the healthcare setting and public are analysed for their expected protective effect. url: https://doi.org/10.1016/j.jhin.2020.09.022 doi: 10.1016/j.jhin.2020.09.022 id: cord-322063-96suqyfg author: Kampmeier, Stefanie title: A nosocomial cluster of vancomycin resistant enterococci among COVID-19 patients in an intensive care unit date: 2020-09-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Currently, hospitals have been forced to divert substantial resources to cope with the ongoing coronavirus disease 2019 (COVID-19) pandemic. It is unclear if this situation will affect long-standing infection prevention practices and impact on healthcare associated infections. Here, we report a nosocomial cluster of vancomycin-resistant enterococci (VRE) that occurred on a COVID-19 dedicated intensive care unit (ICU) despite intensified contact precautions during the current pandemic. Whole genome sequence-based typing (WGS) was used to investigate genetic relatedness of VRE isolates collected from COVID-19 and non-COVID-19 patients during the outbreak and to compare them to environmental VRE samples. METHODS: Five VRE isolated from patients (three clinical and two screening samples) as well as 11 VRE and six vancomycin susceptible Enterococcus faecium (E. faecium) samples from environmental sites underwent WGS during the outbreak investigation. Isolate relatedness was determined using core genome multilocus sequence typing (cgMLST). RESULTS: WGS revealed two genotypic distinct VRE clusters with genetically closely related patient and environmental isolates. The cluster was terminated by enhanced infection control bundle strategies. CONCLUSIONS: Our results illustrate the importance of continued adherence to infection prevention and control measures during the COVID-19 pandemic to prevent VRE transmission and healthcare associated infections. url: https://www.ncbi.nlm.nih.gov/pubmed/32962759/ doi: 10.1186/s13756-020-00820-8 id: cord-003686-1pfk4qve author: Kaneko, Naoe title: The role of interleukin-1 in general pathology date: 2019-06-06 words: 9464.0 sentences: 514.0 pages: flesch: 38.0 cache: ./cache/cord-003686-1pfk4qve.txt txt: ./txt/cord-003686-1pfk4qve.txt summary: The majority of NOD-like receptors such as NLRP1, NLRP3, NLRC4, NLRP6, and NLRP12 can interact with apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) and caspase-1, and the resulting complex is a sensor of cell injury called "inflammasome", an interleukin (IL)-1β-processing platform that plays a crucial role in IL-1β maturation and secretion from cells. NLRP3 inflammasomes have also been reported to be involved in low-grade subclinical inflammation induced by chronic exposure to high levels of free fatty acids and glucose, leading to increased apoptosis and impaired insulin secretion of β-cells in obese type 2 diabetes mellitus (T2D) patients [102] [103] [104] . Canakinumab and anakinra were also effective for patients with Schnitzler syndrome, an adult-onset autoinflammatory disease characterized by focal urticaria and systemic inflammation including fever with bone and muscle pain, in the first placebo-controlled study, and several clinical trials are currently ongoing [186] [187] [188] [189] . abstract: Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance of interleukin-1 in linking innate immunity with a broad spectrum of diseases beyond inflammatory diseases. In this review, we look back on the definition of “inflammation” in traditional general pathology and discuss new insights into interleukin-1 in view of its history and the molecular bases of diseases, as well as current progress in therapeutics. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551897/ doi: 10.1186/s41232-019-0101-5 id: cord-255300-btyth32l author: Kang, Swan title: Oculoplastic video-based telemedicine consultations: Covid-19 and beyond date: 2020-05-12 words: 1176.0 sentences: 65.0 pages: flesch: 44.0 cache: ./cache/cord-255300-btyth32l.txt txt: ./txt/cord-255300-btyth32l.txt summary: Telemedicine offers distinct benefits to patients, clinicians, and communities during the current crisis: it supports social distancing measures by minimising the need for patients and clinicians to travel to hospitals; it enables continued service delivery at a time when in-person outpatient activity has been severely restricted, supporting patients continued access to medical care, promoting patient confidence and reducing patient and clinician anxiety; and reducing the anticipated surge in demand when normal services resume by allowing existing referral, surgery booking, follow-up and discharge pathways to continue. In response to the Covid-19 pandemic, our institution has rapidly deployed video consultations using Attend Anywhere, a browser-based platform that allows clinicians to work through a list of patients in a virtual waiting room. When greater resolution imaging was required, for example of an eyelid lesion, patients were usually able to take a good-quality photograph themselves using a smartphone camera, and digitally transfer this to the evaluating clinician to review, during the video consultation. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32398851/ doi: 10.1038/s41433-020-0953-6 id: cord-018414-6ffhm895 author: Kang, Yoogoo title: Anesthesia Management of Liver Transplantation date: 2016-07-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Anesthesia for liver transplantation pertains to a continuum of critical care of patients with end-stage liver disease. Hence, anesthesiologists, armed with a comprehensive understanding of pathophysiology and physiologic effects of liver transplantation on recipients, are expected to maintain homeostasis of all organ function. Specifically, patients with fulminant hepatic failure develop significant changes in cerebral function, and cerebral perfusion is maintained by monitoring cerebral blood flow and cerebral metabolic rate of oxygen, and intracranial pressure. Hyperdynamic circulation is challenged by the postreperfusion syndrome, which may lead to cardiovascular collapse. The goal of circulatory support is to maintain tissue perfusion via optimal preload, contractility, and heart rate using the guidance of right-heart catheterization and transesophageal echocardiography. Portopulmonary hypertension and hepatopulmonary syndrome have high morbidity and mortality, and they should be properly evaluated preoperatively. Major bleeding is a common occurrence, and euvolemia is maintained using a rapid infusion device. Pre-existing coagulopathy is compounded by dilution, fibrinolysis, heparin effect, and excessive activation. It is treated using selective component or pharmacologic therapy based on the viscoelastic properties of whole blood. Hypocalcemia and hyperkalemia from massive transfusion, lack of hepatic function, and the postreperfusion syndrome should be aggressively treated. Close communication between all parties involved in liver transplantation is also equally valuable in achieving a successful outcome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123279/ doi: 10.1007/978-3-319-07209-8_9 id: cord-001661-dj9bxhwb author: Kao, Kuo-Chin title: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy date: 2015-05-15 words: 4381.0 sentences: 218.0 pages: flesch: 46.0 cache: ./cache/cord-001661-dj9bxhwb.txt txt: ./txt/cord-001661-dj9bxhwb.txt summary: title: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy INTRODUCTION: Diffuse alveolar damage (DAD) is the pathological hallmark of acute respiratory distress syndrome (ARDS), however, the presence of DAD in the clinical criteria of ARDS patients by Berlin definition is little known. A pathological finding of DAD in ARDS patients is associated with hospital mortality and there are no clinical characteristics that could identify DAD patients before open lung biopsy. The following data were collected from the hospital chart of each patient and analyzed: age, sex, underlying diseases, acute physiology and chronic health evaluation (APACHE) II score on the day of ICU admission [28] , sequential organ failure assessment (SOFA) score on the day of ICU admission and the day of open lung biopsy [29] , lung injury score (LIS) [30] , PaO 2 /FiO 2 ratio, PEEP, tidal volume, diagnostic procedures before open lung biopsy (HRCT or BAL), complications related to surgery (i.e., postoperative air leak, pneumothorax, subcutaneous emphysema, bleeding, and wound infection), pathological diagnosis, hospital mortality, and therapeutic alterations. abstract: INTRODUCTION: Diffuse alveolar damage (DAD) is the pathological hallmark of acute respiratory distress syndrome (ARDS), however, the presence of DAD in the clinical criteria of ARDS patients by Berlin definition is little known. This study is designed to investigate the role of DAD in ARDS patients who underwent open lung biopsy. METHODS: We retrospectively reviewed all ARDS patients who met the Berlin definition and underwent open lung biopsy from January 1999 to January 2014 in a referred medical center. DAD is characterized by hyaline membrane formation, lung edema, inflammation, hemorrhage and alveolar epithelial cell injury. Clinical data including baseline characteristics, severity of ARDS, clinical and pathological diagnoses, and survival outcomes were analyzed. RESULTS: A total of 1838 patients with ARDS were identified and open lung biopsies were performed on 101 patients (5.5 %) during the study period. Of these 101 patients, the severity of ARDS on diagnosis was mild of 16.8 %, moderate of 56.5 % and severe of 26.7 %. The hospital mortality rate was not significant difference between the three groups (64.7 % vs 61.4 % vs 55.6 %, p = 0.81). Of the 101 clinical ARDS patients with open lung biopsies, 56.4 % (57/101) patients had DAD according to biopsy results. The proportion of DAD were 76.5 % (13/17) in mild, 56.1 % (32/57) in moderate and 44.4 % (12/27) in severe ARDS and there is no significant difference between the three groups (p = 0.113). Pathological findings of DAD patients had a higher hospital mortality rate than non-DAD patients (71.9 % vs 45.5 %, p = 0.007). Pathological findings of DAD (odds ratio: 3.554, 95 % CI, 1.385–9.12; p = 0.008) and Sequential Organ Failure Assessment score on the biopsy day (odds ratio: 1.424, 95 % CI, 1.187–1.707; p<0.001) were significantly and independently associated with hospital mortality. The baseline demographics and clinical characteristics were not significantly different between DAD and non-DAD patients. CONCLUSIONS: The correlation of pathological findings of DAD and ARDS diagnosed by Berlin definition is modest. A pathological finding of DAD in ARDS patients is associated with hospital mortality and there are no clinical characteristics that could identify DAD patients before open lung biopsy. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449559/ doi: 10.1186/s13054-015-0949-y id: cord-003219-iryb3v0z author: Kao, Kuo-Chin title: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning date: 2018-09-24 words: 4357.0 sentences: 214.0 pages: flesch: 44.0 cache: ./cache/cord-003219-iryb3v0z.txt txt: ./txt/cord-003219-iryb3v0z.txt summary: title: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning CONCLUSIONS: In the present study, in evaluating the effect of prone positioning in patients with influenza pneumonia-related ARDS, pneumonia severity index, renal replacement therapy and increase in dynamic driving pressure were associated with 60-day mortality in patients with influenza pneumonia-related ARDS receiving prone positioning. After multivariate Cox regression analysis, PSI, renal replacement therapy and increased dynamic driving pressure were associated with 60-day mortality in patients with influenza pneumonia-related ARDS receiving prone positioning. The present study in influenza pneumonia-related ARDS patients receiving prone positioning also found that increased dynamic driving pressure (hazard ratio 1.372, 95% confidence interval 1.095-1.718; p = 0.006) was identified as After multivariate Cox regression analysis, it was found that PSI, renal replacement therapy and increased dynamic driving pressure were associated with 60-day mortality in patients with influenza pneumoniarelated ARDS receiving prone positioning. abstract: BACKGROUND: Patients with influenza complicated with pneumonia are at high risk of rapid progression to acute respiratory distress syndrome (ARDS). Prone positioning with longer duration and lung-protective strategies might reduce the mortality level in ARDS. The aim of this study is to investigate the survival predictors of prone positioning in patients with ARDS caused by influenza pneumonia. METHODS: This retrospective study was conducted by eight tertiary referral centers in Taiwan. From January 1 to March 31 in 2016, all of the patients in intensive care units with virology-proven influenza pneumonia were collected, while all of those patients with ARDS and receiving prone positioning were enrolled. Demographic data, laboratory examinations, management records, ventilator settings and clinical outcomes were collected for analysis. RESULTS: During the study period, 336 patients with severe influenza pneumonia were screened and 263 patients met the diagnosis of ARDS. Totally, 65 patients receiving prone positioning were included for analysis. The 60-day survivors had lower Acute Physiology and Chronic Health Evaluation (APACHE) II score, pneumonia severity index (PSI), creatinine level and lower rate of receiving renal replacement therapy than non-survivors (22.4 ± 8.5 vs. 29.2 ± 7.4, p = 0.003; 106.6 ± 40.9 vs. 135.3 ± 48.6, p = 0.019; 1.2 ± 0.9 mg/dL vs. 3.1 ± 3.6 mg/dL, p = 0.040; and 4% vs. 42%, p < 0.005). Multivariate Cox regression analysis identified PSI (hazard ratio 1.020, 95% confidence interval 1.009–1.032; p < 0.001), renal replacement therapy (hazard ratio 6.248, 95% confidence interval 2.245–17.389; p < 0.001), and increase in dynamic driving pressure (hazard ratio 1.372, 95% confidence interval 1.095–1.718; p = 0.006) which were independent predictors associated with 60-day mortality. CONCLUSIONS: In the present study, in evaluating the effect of prone positioning in patients with influenza pneumonia-related ARDS, pneumonia severity index, renal replacement therapy and increase in dynamic driving pressure were associated with 60-day mortality in patients with influenza pneumonia-related ARDS receiving prone positioning. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13613-018-0440-4) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153196/ doi: 10.1186/s13613-018-0440-4 id: cord-029612-cts1al9z author: Kaplan, Alan title: COVID-19 and Healthcare's Productivity Shock date: 2020-06-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The Covid-19 pandemic has highlighted the urgent need for health care providers to abandon volume-based payments in favor of models that give them financial stability in volatile times. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371313/ doi: 10.1056/cat.20.0199 id: cord-303600-96vtj89w author: Kapoor, Deeksha title: Elective Gastrointestinal Surgery in COVID Times date: 2020-10-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: With the COVID pandemic claiming deaths the world over, the healthcare systems were overburdened. This led to the cancellation and delay in elective surgical cases which can have far-reaching consequences This study reports our experience of elective gastro-intestinal surgical procedures during the COVID pandemic, after instating preventive strategies and screening protocols to prevent the transmission of COVID infection. This is a case series analysis of elective gastro-intestinal surgical procedures performed from March 24, 2020, to July 31, 2020. During this period, 314 gastro-intestinal surgical procedures were performed; of which, 45% were for malignancies. The median age of patients was 54 years (range 8 to 94 years). Laparoscopy was used in 43% cases. Major postoperative complications (Clavien-Dindo grade 3 and above) were witnessed in 3.5% (11/314) patients, with no statistically significant difference when compared with the rate of major complications last year (45/914, 4.9% vs 11/314, 3.5%, p = 0.3). The 30-day mortality rate was 1% (n = 3). No patient developed COVID in the postoperative period. With preventive and screening strategies and proper patient selection, it is possible to deliver safe GI surgical services during the COVID pandemic, without increasing the risk for major postoperative complications. url: https://doi.org/10.1007/s12262-020-02642-9 doi: 10.1007/s12262-020-02642-9 id: cord-323965-6mzzibj8 author: Kapoor, Krishan Mohan title: COVID‐19 Pandemic: Consensus Guidelines for Preferred Practices in an Aesthetic Clinic date: 2020-05-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Strict infection control measures in response to the current COVID‐19 pandemic are expected to remain for an extended period. In aesthetic clinics, most procedures are provided on one to one basis by the physician or therapist. In such a scenario, guidelines detailing the infection control measures for aesthetic clinics are of particular importance. METHODS: An online meeting of an international group of experts in the field of aesthetic medicine, with experience in administration of an aesthetic clinic, was convened. The meeting aimed to provide a set of consensus guidelines to protect clinic staff and patients from SARS‐CoV‐2 infection. RESULTS: Consensus guidelines for ‘preferred practices' were provided for scheduling of patients, patient evaluation and triaging, and for safety precautions about the different procedures. Procedures were categorized into low‐risk, moderate risk, and high‐risk based on the likelihood of transmission of SARS‐CoV‐2 virus from the patient to the treating physician or therapist. CONCLUSIONS: While not intended to be complete or exhaustive, these guidelines provide sound infection control measures for aesthetic practices. Since guidelines regarding safety measures and use of PPEs may vary from country to country, the local guidelines should also be followed to prevent COVID‐19 infection in aesthetic clinics. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32415753/ doi: 10.1111/dth.13597 id: cord-030256-muah207b author: Kapoor, Poonam Malhotra title: COVID-19 Thrombosis: An Unsolved Mystery date: 2020-07-24 words: 1649.0 sentences: 92.0 pages: flesch: 49.0 cache: ./cache/cord-030256-muah207b.txt txt: ./txt/cord-030256-muah207b.txt summary: The marked elevation of IL-6 in patients with cytokine release syndrome (CRS) led to the institution of successful targeted therapy for the treatment of CRS using IL-6 receptor blockade (tocilizumab). It is widely acknowledged that the majority of COVID-19 patients, especially those with severe disease, are characterized by lymphocytopenia. Where extracorporeal life support (ECLS) expertise is available, it should be considered according to the standard management algorithm for ARDS in supporting patients with viral lower respiratory tract infection. Although there are no published outcomes, early experience in Wuhan, China, indicates that prone position was widely used in patients with COVID-19 related severe ARDS and had possible benefits. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study United States Center for Disease Control interim guidance for clinical management of COVID-19 patients with and without acute respiratory distress syndrome abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416208/ doi: 10.1055/s-0040-1715279 id: cord-288040-uuqfvvmk author: Kapoor, Saloni title: Developing a pediatric ophthalmology telemedicine program in the COVID-19 crisis date: 2020-09-02 words: 3080.0 sentences: 175.0 pages: flesch: 47.0 cache: ./cache/cord-288040-uuqfvvmk.txt txt: ./txt/cord-288040-uuqfvvmk.txt summary: Synchronous telemedicine can be further divided into encounters scheduled for the provider by a scheduler, with the patient being given specific instructions as to how to join a virtual clinic room at a given time or can be triggered by a patient wanting advice or an examination as the need arises, with a provider team available 24/7. The medical records of patients to be seen at the Ophthalmology Department of UPMC Children''s Hospital of Pittsburgh between March 21 and April 10 were reviewed by a provider (MP, KKN, PP, EM, CL EK), and all visits in the study period were categorized as follows: (1) requiring an in-person visit, (2) face-to-face visit that could be postponed, and (3) consultation required but could be virtual. To ensure that patients were consistently informed that their physician deemed the visit to be necessary and that it could be completed via telemedicine, a standardized script was used by schedulers. abstract: Purpose To describe our methodology for implementing synchronous telemedicine during the 2019 novel coronavirus (COVID-19) pandemic. Methods A retrospective review of outpatient records at a single children’s hospital from March 21 to April 10, 2020, was carried out to determine the outcome of already-scheduled face-to-face outpatient appointments. The week leading up to the March 21, all appointments in the study period were categorized as follows: (1) requiring an in-person visit, (2) face-to-face visit that could be postponed, and (3) consultation required but could be virtual. Teams of administrators, schedulers, and ophthalmic technicians used defined scripts and standardized emails to communicate results of categorization to patients. Flowcharts were devised to schedule and implement telemedicine visits. Informational videos were made accessible on social media to prepare patients for the telemedicine experience. Simultaneously our children’s hospital launched a pediatric on-demand e-consult service, the data analytics of which could be used to determine how many visits were eye related. Results A total of 237 virtual ophthalmology consult visits were offered during the study period: 212 were scheduled, and 206 were completed, of which 43 were with new patients and 163 with returning patients. Following the initial virtual visit, another was required on average in 4 weeks by 21 patients; in-person follow-up was required for 170 patients on average 4.6 months after the initial virtual visit. None needed review within 72 hours. The pediatric on-demand service completed 290 visits, of which 25 had eye complaints. Conclusions With proper materials, technology, and staffing, a telemedicine strategy based on three patient categories can be rapidly implemented to provide continued patient care during pandemic conditions. In our study cohort, the scheduled clinic e-visits had a low no-show rate (3%), and 8% of the on-demand virtual access for pediatric care was eye related. url: https://api.elsevier.com/content/article/pii/S109185312030166X doi: 10.1016/j.jaapos.2020.05.008 id: cord-257147-i48qljv6 author: Karakas, Mahir title: Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) date: 2020-08-11 words: 3501.0 sentences: 191.0 pages: flesch: 47.0 cache: ./cache/cord-257147-i48qljv6.txt txt: ./txt/cord-257147-i48qljv6.txt summary: Clinical information for the 8 patients before and after the Adrecizumab administration was obtained from the hospital information system and included the following: demographic data, including anamnesis and physical examination; treatment and therapies, including mechanical ventilation and antiviral therapies; clinical data, including PaO2/FiO2, the SOFA score (range 0-24, with higher scores indicating a more severe illness), and the SAPS-II score (higher scores indicating a more severe illness); and laboratory data, including bio-ADM, DPP3, the white blood cell count, lactate, the liver and kidney function, and inflammatory factors (CRP, procalcitonin, and interleukin-6). In this preliminary uncontrolled case series of eight extreme-critically ill patients with COVID-19 and ARDS, the administration of the non-neutralizing anti-ADM antibody Adrecizumab was followed by a favorable outcome. In this preliminary uncontrolled case series of eight extreme-critically ill patients with COVID-19 and ARDS, the administration of the non-neutralizing anti-ADM antibody Adrecizumab was followed by a favorable outcome. abstract: Recently, the stabilization of the endothelium has been explicitly identified as a therapeutic goal in coronavirus disease 2019 (COVID-19). Adrecizumab (HAM8101) is a first-in-class humanized monoclonal anti-Adrenomedullin (anti-ADM) antibody, targeting the sepsis- and inflammation-based vascular and capillary leakage. Within a “treatment on a named-patient basis” approach, Adrecizumab was administered to eight extreme-critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS). The patients received a single dose of Adrecizumab, which was administered between 1 and 3 days after the initiation of mechanical ventilation. The SOFA (median 12.5) and SAPS-II (median 39) scores clearly documented the population at highest risk. Moreover, six of the patients suffered from acute renal failure, of whom five needed renal replacement therapy. The length of follow-up ranged between 13 and 27 days. Following the Adrecizumab administration, one patient in the low-dose group died at day 4 due to fulminant pulmonary embolism, while four were in stable condition, and three were discharged from the intensive care unit (ICU). Within 12 days, the SOFA score, as well as the disease severity score (range 0–16, mirroring critical resources in the ICU, with higher scores indicating more severe illness), decreased in five out of the seven surviving patients (in all high-dose patients). The PaO2/FiO2 increased within 12 days, while the inflammatory parameters C-reactive protein, procalcitonin, and interleukin-6 decreased. Importantly, the mortality was lower than expected and calculated by the SOFA score. In conclusion, in this preliminary uncontrolled case series of eight shock patients with life-threatening COVID-19 and ARDS, the administration of Adrecizumab was followed by a favorable outcome. Although the non-controlled design and the small sample size preclude any definitive statement about the potential efficacy of Adrecizumab in critically ill COVID-19 patients, the results of this case series are encouraging. url: https://www.ncbi.nlm.nih.gov/pubmed/32796765/ doi: 10.3390/biom10081171 id: cord-291025-u5z8zji3 author: Karami, Parisa title: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings date: 2020-04-11 words: 2872.0 sentences: 157.0 pages: flesch: 50.0 cache: ./cache/cord-291025-u5z8zji3.txt txt: ./txt/cord-291025-u5z8zji3.txt summary: title: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings According to the data, several clinical outcomes such as sepsis, respiratory failure, acute respiratory distress syndrome (ARDS), septic shock, coagulopathy, acute cardiac injury, and acute kidney injury are significantly (all P-values < 0.0001) higher in non-survivor patients compared to survivors. To our knowledge, this case is the first maternal death reported for pregnant patients diagnosed with COVID-19 so far. An early study has evaluated the outcome of nine pregnant patients with COVID-19 without any specific underlying diagnosed diseases (all gestational ages ≥36 weeks). Another study evaluated 13 pregnant patients (two cases < and 11 cases≥ 28 week of gestation) diagnosed with COVID-19. This case with the mentioned clinical, imaging, and laboratory data was the first report of COVID-19 pregnancy mortality. abstract: This report highlights details on a pregnant case of COVID-19 who unfortunately did not survive. This 27-year-old woman at her 30 and 3/7 weeks’ gestation was referred to our center with fever, myalgia, and cough. The laboratory investigations showed leukopenia and lymphopenia as well as increased creatinine and CRP levels. The first chest X-ray (faint bilateral patchy opacities) and CT scan (some faint subpleural ground-glass opacities associated with pleural thickening) were not typical for initial COVID-19 pulmonary infection, however, the treatment for COVID-19 was started. Due to respiratory distress, she was intubated and put under mechanical ventilation. After a while, the fetus was born with Apgar score of 0 and did not react to the neonatal cardiopulmonary resuscitation protocol. Finally, due to deterioration in the clinical and imaging findings, the patient was expired as a result of multi-organ failure. Following the death, autopsy was performed and the histopathologic evaluations of the lungs showed evidence of viral pneumonia (viral cytopathic effect and a mild increase in alveolar wall thickness) and ARDS (hyaline membrane). Also, reverse transcription-polymerase chain reaction (RT-PCR) confirmed SARS-CoV-2 infection in the lungs. To our knowledge, this is the first report of maternal death with confirmed COVID-19 infection. url: https://www.sciencedirect.com/science/article/pii/S1477893920301332 doi: 10.1016/j.tmaid.2020.101665 id: cord-345727-bcxkycjh author: Karimata, Yosuke title: Clinical Features of Human Metapneumovirus Pneumonia in Non-Immunocompromised Patients: An Investigation of Three Long-Term Care Facility Outbreaks date: 2018-09-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Several studies have reported outbreaks due to human metapneumovirus (hMPV) in long-term care facilities (LTCF) for the elderly. However, most of these reports are epidemiological studies and do not investigate the clinical features of hMPV pneumonia. METHODS: Three independent outbreaks of hMPV occurred at separate LTCF for intellectually challenged and elderly residents. A retrospective evaluation of hMPV pneumonia and its clinical and radiological features was conducted using available medical records and data. RESULTS: In 105 hMPV infections, 49% of patients developed pneumonia. The median age of pneumonia cases was significantly higher than non-pneumonia cases (P < .001). Clinical manifestations of hMPV pneumonia included high fever, wheezing in 43%, and respiratory failure in 31% of patients. An elevated number of white blood cells as well as increased levels of C-reactive protein, creatine phosphokinase, and both aspartate and alanine transaminases was also observed among pneumonia cases. Evaluation of chest imaging revealed proximal bronchial wall thickenings radiating outward from the hilum in most patients. CONCLUSIONS: The aforementioned characteristics should be considered as representative of hMPV pneumonia. Patients presenting with these features should have laboratory testing performed for prompt diagnosis. url: https://www.ncbi.nlm.nih.gov/pubmed/29733351/ doi: 10.1093/infdis/jiy261 id: cord-303363-uu9hb1c9 author: Karimi, Mehran title: Implications of SARSr-CoV 2 infection in thalassemias: Do patients fall into the “high clinical risk” category? date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We’re all flying blind regarding coronavirus, but it’s fair to think if thalassemic patients are particularly vulnerable to SARS-COV-2 infection or are at potential higher risk of complications from COVID-19 than normal population, specially when they become older. The frustrating thing is that, right now, this virus is still new. It only came to the attention of the World Health Organization at the end of December. Very few cases in thalassemia have so far been reported; is this due to lack of testing or a true lack of infection/susceptibility? However, we believe that more data should be collected to better characterise the impact of SARS-CoV-2 infection in patients with thalassemias. Therefore, a multicenter registry and the collection of comprehensive data from both positive COVID-19 thalassemia major and non-transfusion dependent thalassemia are necessary to clarify debated issues. In the meantime an early and vigilant monitoring along with high quality supportive care are needed in thalassemic patients at high risk for SARS-CoV-2 infection. (www.actabiomedica.it) url: https://www.ncbi.nlm.nih.gov/pubmed/32420925/ doi: 10.23750/abm.v91i2.9592 id: cord-340164-vzdyy656 author: Karimi, Zohreh title: The Lived Experience of Nurses Caring for Patients with COVID-19 in Iran: A Phenomenological Study date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: This study aimed to explore the lived experiences of nurses caring for patients with COVID-19 in Iran. METHODS: This study was a descriptive phenomenology. Sampling was purposefully performed, and participants were selected in terms of the inclusion criteria. Data were collected through semi-structured interviews using the WhatsApp mobile messaging application. Colaizzi’s method was used to analyse the data. The criteria introduced by Lincoln and Guba were used for the study rigour. RESULTS: The data were obtained from 12 nurses caring for patients with COVID-19. The mean age of the participants was 29.41 years (SD = 2.72) with a mean work experience of 6.75 years (SD = 2.52). Three main themes and six subthemes were identified: mental condition (subthemes included “anxiety and stress” and “fear”), emotional condition (subthemes included “suffering and affliction” and “waiting for death”), and care context (subthemes included “turmoil” and “lack of support and equipment”). CONCLUSION: The results of this study show that nurses working in the wards and care centres designated for patients with COVID-19 are experiencing mental and emotional distress and are working in inadequate professional conditions. url: https://www.ncbi.nlm.nih.gov/pubmed/32904130/ doi: 10.2147/rmhp.s258785 id: cord-104467-elwfz1gk author: Kariyanna, Pramod Theetha title: A Systematic Review of COVID-19 and Myocarditis date: 2020-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND. The COVID-19 infection which emerged in December 2019, is caused by the virus SARS-CoV-2. Infection with this virus can lead to severe respiratory illness, however, myocarditis has also been reported. The purpose of this study is to identify the clinical features of myocarditis in COVID-19 patients. METHODS. A systematic review was conducted to investigate characteristics of myocarditis in patients infected with COVID-19 using the search term “Coronavirus” or “COVID” and “myocarditis,” “heart,” or “retrospective.” Case reports and retrospective studies were gathered by searching Medline/Pubmed, Google Scholar, CINAHL, Cochrane CENTRAL, and Web of Science databases. 11 articles were selected for review. RESULTS. COVID-19 myocarditis affected patients over the age of 50 and incidences among both genders were equally reported. Patients presented with dyspnea, cough, fever with hypotension and chest pain. Laboratory tests revealed leukocytosis with increased C-reactive protein, while arterial blood gas analysis demonstrated respiratory acidosis. All cardiac markers were elevated. Radiographic imaging of the chest showed bilateral ground glass opacities or bilateral infiltrates, while cardiac magnetic resonance imaging produced late gadolinium enhancements. Electrocardiography demonstrated ST-segment elevation or inverted T waves, while echocardiography revealed reduced left ventricular ejection fraction with cardiomegaly or increased wall thickness. Management with corticosteroids was favored in most cases, followed by antiviral medication. The majority of studies reported either recovery or no further clinical deterioration. CONCLUSION. Current available data on COVID-19 myocarditis is limited. Further research is needed to advance our understanding of COVID-19 myocarditis. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397751/ doi: nan id: cord-338683-nzgnpi6f author: Karligkiotis, Apostolos title: Changing paradigms in sinus and skull base surgery as the COVID‐19 pandemic evolves: Preliminary experience from a single Italian tertiary care center date: 2020-06-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Italy was the first European country suffering from COVID‐19. Health care resources were redirected to manage the pandemic. We present our initial experience with the management of urgent and nondeferrable surgeries for sinus and skull base diseases during the COVID‐19 pandemic. METHODS: A retrospective review of patients treated in a single referral center during the first 2 months of the pandemic was performed. A comparison between the last 2‐month period and the same period of the previous year was carried out. RESULTS: Twenty‐four patients fulfilled the inclusion criteria. A reduction of surgical activity was observed (−60.7%). A statistically significant difference in pathologies treated was found (P = .016), with malignancies being the most frequent indication for surgery (45.8%). CONCLUSIONS: Although we feel optimistic for the future, we do not feel it is already time to restart elective surgeries. Our experience may serve for other centers who are facing the same challenges. url: https://www.ncbi.nlm.nih.gov/pubmed/32510716/ doi: 10.1002/hed.26320 id: cord-021742-sdz6d1r5 author: Karnik, Ankur A. title: Pneumothorax and Barotrauma date: 2009-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151955/ doi: 10.1016/b978-032304841-5.50050-9 id: cord-290065-ouua7wnq author: Kashi, Mahine title: Severe arterial thrombosis associated with Covid-19 infection date: 2020-05-16 words: 705.0 sentences: 52.0 pages: flesch: 40.0 cache: ./cache/cord-290065-ouua7wnq.txt txt: ./txt/cord-290065-ouua7wnq.txt summary: title: Severe arterial thrombosis associated with Covid-19 infection • We observed very severe arterial thrombotic complications in COVID-19 patients with cardiovascular history despite the use of antiplatelet or anticoagulant therapy, including five irreversible lower limb ischemia and two thoracic aortic free floating thrombi. • Further studies are needed to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients with peripheral arterial occlusive disease or thrombophilia. reporting the incidence of thrombotic complications in critically ill ICU patients diagnosed with Covid-19 1 . We report seven cases of severe arterial thrombotic events in patients infected with Covid-19. On We describe very severe arterial thrombotic complications occurring in COVID-19 patients despite the use of antiplatelet or anticoagulant therapy, including irreversible lower limb ischemia and free floating thrombi in the thoracic aorta. Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy abstract: • Increased incidence of venous thrombosis has been demonstrated in SARS-CoV2 infected patients but no data are available for arterial thrombosis. • We observed very severe arterial thrombotic complications in COVID-19 patients with cardiovascular history despite the use of antiplatelet or anticoagulant therapy, including five irreversible lower limb ischemia and two thoracic aortic free floating thrombi. • Three patients were in intensive care unit (ICU) and two of them also presented VTE, one deep vein thrombosis and one segmental PE. • Further studies are needed to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients with peripheral arterial occlusive disease or thrombophilia. url: https://doi.org/10.1016/j.thromres.2020.05.025 doi: 10.1016/j.thromres.2020.05.025 id: cord-010929-d598h08w author: Kashiwagi, Hirokazu title: Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision date: 2020-01-02 words: 11814.0 sentences: 563.0 pages: flesch: 42.0 cache: ./cache/cord-010929-d598h08w.txt txt: ./txt/cord-010929-d598h08w.txt summary: Patients who do not achieve the therapeutic target with corticosteroids or require long-term administration of high-dose corticosteroids, or patients unable to tolerate corticosteroids due to complications or adverse drug reactions, are transitioned to second-line treatment. High-dose intravenous immunoglobulin, methylprednisolone pulse therapy, or platelet transfusion should be considered for patients with severe bleeding symptoms, marked thrombocytopenia or who urgently require an increase in their platelet count because of surgery or for some other reason. In patients with underlying diseases (hypertension,diabetes,active infections, chronic infections,impaired immune status,osteoporosis,dys lipidemia,peptic ulcer, etc.) with a high probability of problematic adverse drug reactions associated with corticosteroid treatment, it is recommended that corticosteroids be started while controlling complications. However, the percentage of patients who had a partial response with a platelet count of 30,000-50,000/μL was 57.6% in the rituximab group and 46.7% in the standard treatment group, with a relative risk of 1.26 (95% CI: 0.95-1.67, p = 0.11), indicating that there was no significant difference in the bleeding inhibition effect between the two groups. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223085/ doi: 10.1007/s12185-019-02790-z id: cord-324175-5c4ijkpm author: Kassas, Mohamed El title: COVID-19 in Egypt: Through Crisis to Adaptation; a gastroenterologist’s Perspective date: 2020-07-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32798187/ doi: 10.1016/j.ajg.2020.07.004 id: cord-289852-4uxb70rh author: Kassem, Dina H. title: Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis date: 2020-09-30 words: 6959.0 sentences: 342.0 pages: flesch: 44.0 cache: ./cache/cord-289852-4uxb70rh.txt txt: ./txt/cord-289852-4uxb70rh.txt summary: Thus, harnessing the immunomodulatory properties of mesenchymal stem cells (MSCs) to ameliorate that cytokine-storm can indeed provide a golden key for the treatment of COVID-19 patients, especially severe cases. In fact, MSCs transplantation can improve the overall outcome of COVID-19 patients via multiple mechanisms; first through their immunomodulatory effects which will help to regulate the infected patient inflammatory response, second via promoting tissue-repair and regeneration, and third through their antifibrotic effects. Similar studies are also warranted to compare the therapeutic benefit of a certain MSCs type, and its derived EVs. Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies Expanded umbilical cord mesenchymal stem cells (UC-MSCs) as a therapeutic strategy in managing critically ILL COVID-19 patients: the case for compassionate use Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial abstract: Corona virus disease 2019 (COVID-19) is a global public health crisis. The high infectivity of the disease even from non-symptomatic infected patients, together with the lack of a definitive cure or preventive measures are all responsible for disease outbreak. The severity of COVID-19 seems to be mostly dependent on the patients’ own immune response. The over-activation of the immune system in an attempt to kill the virus, can cause a “cytokine storm” which in turn can induce acute respiratory distress syndrome (ARDS), as well as multi-organ damage, and ultimately may lead to death. Thus, harnessing the immunomodulatory properties of mesenchymal stem cells (MSCs) to ameliorate that cytokine-storm can indeed provide a golden key for the treatment of COVID-19 patients, especially severe cases. In fact, MSCs transplantation can improve the overall outcome of COVID-19 patients via multiple mechanisms; first through their immunomodulatory effects which will help to regulate the infected patient inflammatory response, second via promoting tissue-repair and regeneration, and third through their antifibrotic effects. All these mechanisms will interplay and intervene together to enhance lung-repair and protect various organs from any damage resulting from exaggerated immune-response. A therapeutic modality which provides all these mechanisms undoubtedly hold a strong potential to help COVID-19 patients even those with the worst condition to hopefully survive and recover. url: https://doi.org/10.3389/fcell.2020.587866 doi: 10.3389/fcell.2020.587866 id: cord-018182-lleti89n author: Kassutto, Stacey M. title: Care of the Surgical ICU Patient with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension date: 2016-10-09 words: 6222.0 sentences: 310.0 pages: flesch: 32.0 cache: ./cache/cord-018182-lleti89n.txt txt: ./txt/cord-018182-lleti89n.txt summary: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are frequently encountered in the intensive care unit (ICU). Important differential diagnoses in patients with severe dyspnea and/or impending respiratory failure include congestive heart failure, acute coronary syndrome, pulmonary embolism, cardiac arrhythmia, pneumothorax, pleural effusion, acute infectious processes such as bacterial or viral pneumonia, and exacerbations of other underlying pulmonary conditions such as interstitial lung disease. Given their complexity, the use of RHC and ongoing invasive hemodynamic monitoring is recommended for patients with evidence of RV failure requiring ICU admission, particularly in the setting of vasoactive agent titration [32] . Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbations of chronic obstructive pulmonary disease Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease Noninvasive positive pressure ventilation in the setting of severe acute exacerbations of chronic obstructive pulmonary disease: more effective and less expensive abstract: Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease characterized by airflow limitation that is frequently progressive and associated with respiratory impairment. As the fourth leading cause of death in the United States and Europe, COPD results in a substantial and ever increasing economic and social burden [1]. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are frequently encountered in the intensive care unit (ICU). Although there is no standardized definition, AECOPD are characterized by a significant change in patient symptoms from baseline accompanied by overall increased airway resistance [2]. These exacerbations carry a significant risk to patients, with 10 % in-hospital mortality and 1-year and 2-year all-cause mortality rates of 43 % and 49 %, respectively, in patients with hypercapnic exacerbations [3]. Other studies note in-hospital mortality rates as high as 30 % with worse outcomes associated with older age, severity of respiratory and non-respiratory organ dysfunction, and hospital length of stay [4]. Given that patients transferred to the ICU with AECOPD are at high risk for complications and adverse outcomes, early diagnosis and management are critical to improve patient outcomes and survival in this population. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122996/ doi: 10.1007/978-3-319-33341-0_13 id: cord-282504-m3npy0om author: Kastritis, Efstathios title: Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID‐19 pandemic date: 2020-06-01 words: 4642.0 sentences: 217.0 pages: flesch: 44.0 cache: ./cache/cord-282504-m3npy0om.txt txt: ./txt/cord-282504-m3npy0om.txt summary: Patients with light chain (AL) amyloidosis have an underlying usually low-grade plasma or B-cell malignancy causing their disease, and they receive chemotherapy (Merlini, et al 2018) , thus, being at higher risk for infections (Kristinsson, et al 2012) , including from SARS-CoV-2, and probably at higher risk for severe COVID-19 (Pietrantonio and Garassino 2020) . Treatments for AL amyloidosis have not been developed in the context of multiple randomized studies, thus, we have limited data to propose one therapy over the other or assess the importance of full vs reduced dosing of critical drugs such as bortezomib or For selected patients who have achieved a satisfactory hematologic response (for example CR or VGPR or even PR with organ response), the treating physician may discuss to complete therapy earlier or continue with a less intensive schedule (for example reduce weekly to bi-weekly bortezomib). abstract: The SARS‐CoV‐2‐associated disease (COVID‐19) is primarily manifested as a respiratory tract infection but may affect and cause complications from multiple organ systems (cardiovascular, gastrointestinal, kidneys, hematopoietic and immune systems) while no proven specific therapy exists. The challenges associated with COVID‐19 are even greater for patients with light chain (AL) amyloidosis, a rare multisystemic disease affecting the heart, kidneys, liver, gastrointestinal and nervous system. Patients with AL amyloidosis may need to receive chemotherapy, which probably increases infection risk. Management of COVID‐19 may be particularly challenging in patients with AL amyloidosis who often present with cardiac dysfunction, nephrotic syndrome, neuropathy, low blood pressure and gastrointestinal symptoms. In addition, AL patients may be more susceptible to toxicities of drugs used to manage COVID‐19. Access to health care may be difficult or limited, diagnosis of AL amyloidosis may be delayed with detrimental consequences, treatment administration may need modification. Both patients and treating physicians need to adapt in a new reality. url: https://doi.org/10.1111/bjh.16898 doi: 10.1111/bjh.16898 id: cord-327442-e02y93f6 author: Kastritis, Efstathios title: Systemic autoimmune diseases, anti-rheumatic therapies, COVID-19 infection risk and patient outcomes date: 2020-07-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As of June 10th 2020 about 7.2 million individuals have tested positive for, and more than 410,000 have died due to COVID-19. In this review we outline the pathophysiology that underpins the potential use of anti-rheumatic therapies for severe COVID-19 infection and summarize the current evidence regarding the risk and outcome of COVID-19 in patients with systemic autoimmune diseases. Thus far there is no convincing evidence that any disease-modifying anti-rheumatic drug (conventional synthetic, biologic or targeted synthetic) including hydroxychloroquine, may protect against severe COVID-19 infection; answers about their possible usefulness in the management of the cytokine storm associated with severe COVID-9 infection will only arise from ongoing randomized controlled trials. Evidence on COVID-19 risk and outcome in patients with systemic autoimmune diseases is extremely limited; thus, any conclusions would be unsafe and should be seen with great caution. At present, the risk and severity (hospitalization, intensive care unit admission and death) of COVID-19 infection in people with autoimmune diseases do not appear particularly dissimilar to the general population, with the possible exception of hospitalization in patients exposed to high glucocorticoid doses. At this stage it is impossible to draw any conclusions for differences in COVID-19 risk and outcome between different autoimmune diseases and between the various immunomodulatory therapies used for them. More research in the field is obviously required, including as a minimum careful and systematic epidemiology and appropriately controlled clinical trials. url: https://doi.org/10.1007/s00296-020-04629-x doi: 10.1007/s00296-020-04629-x id: cord-352969-rpt7xja6 author: Kataria, Ashish title: COVID-19 in Kidney Transplantation: Epidemiology, Management Considerations, and the Impact on Kidney Transplant Practice date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel severe acute respiratory syndrome coronavirus 2 was identified in the late 2019 as the cause of coronavirus disease 2019 (COVID-19), an acute respiratory viral illness. Patients with chronic underlying conditions may have an increased risk of morbidity and mortality from COVID-19. Kidney transplant recipients may be at a uniquely increased risk of serious complications from COVID-19 as compared to the general population because of a chronically immunosuppressed state and a high prevalence of comorbidities like diabetes, heart disease, and lung disease. Early data suggest that the mortality of patients on dialysis may be comparable to those with kidney transplants, although more research is needed. This concise review aims to describe the epidemiology of COVID-19 in kidney transplant recipients, manifestations, appropriate management, and clinical outcomes based on the available literature. Current evidence on many of the specific antiviral measures against COVID-19 has not shown a clear-cut benefit in smaller studies and the results of several ongoing larger clinical trials are awaited. In addition, we also highlight the impact of COVID-19 on kidney transplant center practice and volumes; potential living or deceased donors, recipients; and induction immunosuppression and surgical strategies. url: https://doi.org/10.1097/txd.0000000000001031 doi: 10.1097/txd.0000000000001031 id: cord-258315-yt1ytasw author: Kato, Hideaki title: Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship date: 2020-05-13 words: 1776.0 sentences: 111.0 pages: flesch: 54.0 cache: ./cache/cord-258315-yt1ytasw.txt txt: ./txt/cord-258315-yt1ytasw.txt summary: title: Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship Abstract We investigated the clinical course of individuals with 2019 novel coronavirus disease (COVID-19) who were transferred from the Diamond Princess cruise ship to 12 local hospitals. In this study, we describe the clinical conditions, treatment, and the clinical course of the patients positive for SARS-CoV-2 who were transferred from the Diamond Princess cruise ship for further medical care to the participating hospitals in this study. The patients'' vital signs, laboratory data, chest radiographs, or computed tomography (CT) findings at the time of admission and treatment, and the data on the clinical course and prognosis were collected using case report forms. Notably, the severity of this disease in the patients transferred from the cruise ship was very high compared with that previously reported in the general population in China [5, 6] . abstract: Abstract We investigated the clinical course of individuals with 2019 novel coronavirus disease (COVID-19) who were transferred from the Diamond Princess cruise ship to 12 local hospitals. The conditions and clinical courses of patients with pneumonia were compared with those of patients without pneumonia. Among 70 patients (median age: 67 years) analyzed, the major symptoms were fever (64.3%), cough (54.3%), and general fatigue (24.3%). Forty-three patients (61.4%) had pneumonia. Higher body temperature, heart rate, and respiratory rate as well as higher of lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and C-reactive protein (CRP) levels and lower serum albumin level and lymphocyte count were associated with the presence of pneumonia. Ground-glass opacity was found in 97.7% of the patients with pneumonia. Patients were administered neuraminidase inhibitors (20%), lopinavir/ritonavir (32.9%), and ciclesonide inhalation (11.4%). Mechanical ventilation and veno-venous extracorporeal membrane oxygenation was performed on 14 (20%) and 2 (2.9%) patients, respectively; two patients died. The median duration of intubation was 12 days. The patients with COVID-19 transferred to local hospitals during the outbreak had severe conditions and needed close monitoring. The severity of COVID-19 depends on the presence of pneumonia. High serum LDH, AST and CRP levels and low serum albumin level and lymphocyte count were found to be predictors of pneumonia. It was challenging for local hospitals to admit and treat these patients during the outbreak of COVID-19. Assessment of severity was crucial to manage a large number of patients. url: https://www.sciencedirect.com/science/article/pii/S1341321X20301616?v=s5 doi: 10.1016/j.jiac.2020.05.005 id: cord-018840-ts2g1ux7 author: Katragkou, Aspasia title: Role of Immunoglobulin Therapy to Prevent and Treat Infections date: 2018-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Immunoglobulins have been used widely in medicine for a variety of diseases including infectious diseases. While the main clinical applications of immunoglobulin therapy concern their use as replacement for patients with primary immunodeficiencies, or as treatment for autoimmune and inflammatory disorders, their role in infectious disease is limited largely to viral and toxin neutralization and replacement therapy in patients with immunoglobulin deficiencies. Many aspects of the therapeutic regimen of immunoglobulins even in the established indications remain open. Recently, due to the worldwide surge of immunosuppression caused by AIDS, organ transplantation, cancer, and autoimmune therapies, as well as the emergence of multidrug-resistant bacteria, there has been renewed interest in the use of antibody preparation to prevent infections in high-risk groups. Knowing the limitations of the current anti-infective armamentarium, approaches that target the host through manipulations to augment the host immune response provide a helpful aid to conventional treatment options. A substantial body of evidence has demonstrated that strategies aiming to support or stimulate immune response could be feasible approaches that would benefit immunocompromised patients. In the present chapter, we present contemporary indications of immunoglobulin administration for therapy and prophylaxis of infections in the immunocompromised population. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123824/ doi: 10.1007/978-3-319-77674-3_17 id: cord-297494-6yxmaihl author: Katsurada, Naoko title: The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study date: 2017-12-06 words: 4336.0 sentences: 217.0 pages: flesch: 38.0 cache: ./cache/cord-297494-6yxmaihl.txt txt: ./txt/cord-297494-6yxmaihl.txt summary: However, influenza virus A and B were associated with three-fold higher mortality in patients with chronic respiratory disease but not with other comorbidities (ARR 3.38, 95% CI 1.54–7.42). We conducted this prospective multicentre study to determine the distribution of viruses associated with pneumonia in adults and to establish their virus-specific effects on pneumonia mortality stratified by age group and comorbidity status. To the best of our knowledge, this study is the first to systematically investigate virus-specific effects on pneumonia mortality by age group and comorbidity status among adults. In our study, multiple viruses were identified in 5.1% of virus-associated pneumonia and were associated with higher mortality than single viral infection in patients with chronic respiratory disease and other comorbidities. Systematic reviews have shown that multiple viral infections in patients with respiratory disease are not associated with disease severity [27, 28] ; however, the majority of previous studies included young children but not adults. abstract: BACKGROUND: Various viruses are known to be associated with pneumonia. However, the impact of viral infections on adult pneumonia mortality remains unclear. This study aimed to clarify the effect of virus infection on pneumonia mortality among adults stratified by virus type and patient comorbidities. METHODS: This multicentre prospective study enrolled pneumonia patients aged ≥15 years from September 2011 to August 2014. Sputum samples were tested by in-house multiplex polymerase chain reaction assays to identify 13 respiratory viruses. Viral infection status and its effect on in-hospital mortality were examined by age group and comorbidity status. RESULTS: A total of 2617 patients were enrolled in the study and 77.8% was aged ≥65 years. 574 (21.9%) did not have comorbidities, 790 (30.2%) had chronic respiratory disease, and 1253 (47.9%) had other comorbidities. Viruses were detected in 605 (23.1%) patients. Human rhinovirus (9.8%) was the most frequently identified virus, followed by influenza A (3.9%) and respiratory syncytial virus (3.9%). Respiratory syncytial virus was more frequently identified in patients with chronic respiratory disease (4.7%) than those with other comorbidities (4.2%) and without comorbidities (2.1%) (p = 0.037). The frequencies of other viruses were almost identical between the three groups. Virus detection overall was not associated with increased mortality (adjusted risk ratio (ARR) 0.76, 95% CI 0.53–1.09). However, influenza virus A and B were associated with three-fold higher mortality in patients with chronic respiratory disease but not with other comorbidities (ARR 3.38, 95% CI 1.54–7.42). Intriguingly, paramyxoviruses were associated with dramatically lower mortality in patients with other comorbidities (ARR 0.10, 95% CI 0.01–0.70) but not with chronic respiratory disease. These effects were not affected by age group. CONCLUSIONS: The impact of virus infections on pneumonia mortality varies by virus type and comorbidity status in adults. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-017-2858-y) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1186/s12879-017-2858-y doi: 10.1186/s12879-017-2858-y id: cord-017461-xw02c7u5 author: Kauffman, Carol A. title: Fungal Infections date: 2009-02-02 words: 5446.0 sentences: 294.0 pages: flesch: 40.0 cache: ./cache/cord-017461-xw02c7u5.txt txt: ./txt/cord-017461-xw02c7u5.txt summary: Candida species are the most common cause of opportunistic fungal infections, and bloodstream infections are usually treated with fluconazole or an echinocandin antifungal agent. The endemic fungi, Histoplasma capsulatum, Coccidioides species, and Blastomyces dermatitidis, cause infection when the mold form is dispersed and inhaled from the environment in those specific areas of the country in which these organisms flourish. Amphotericin B is used for initial treatment of severe histoplasmosis, coccidioi­domycosis, and blastomycosis; itraconazole is the therapy of choice for most mild to moderate infections due to these endemic mycoses. Serious fungal infections can be separated into two major categories: The opportunistic mycoses that include candidiasis, cryptococcosis, and invasive mold infections such as aspergillosis and zygomycosis, and the endemic mycoses, which in the United States, includes histoplasmosis, blastomycosis, and coccidioidomycosis. abstract: Older adults are at increased risk of developing opportunistic fungal infections because organ transplantation, intensive cancer chemotherapy regimens, and anti-tumor necrosis factor agents are now used more commonly, and because admission to an intensive care unit, which carries many risk factors for fungal infection, has become commonplace in this group. Candida species are the most common cause of opportunistic fungal infections, and bloodstream infections are usually treated with fluconazole or an echinocandin antifungal agent. Invasive mold infections are mostly caused by Aspergillus species; in older adults, they cause primarily pulmonary and sinus infections, and they are associated with a high mortality rate. The endemic fungi, Histoplasma capsulatum, Coccidioides species, and Blastomyces dermatitidis, cause infection when the mold form is dispersed and inhaled from the environment in those specific areas of the country in which these organisms flourish. Amphotericin B is used for initial treatment of severe histoplasmosis, coccidioi­domycosis, and blastomycosis; itraconazole is the therapy of choice for most mild to moderate infections due to these endemic mycoses. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122029/ doi: 10.1007/978-1-60327-534-7_22 id: cord-002626-jzwwses4 author: Kaul, Karen L. title: The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care date: 2017-07-16 words: 14822.0 sentences: 754.0 pages: flesch: 40.0 cache: ./cache/cord-002626-jzwwses4.txt txt: ./txt/cord-002626-jzwwses4.txt summary: Clinical laboratories have thus had to develop new assays or modified the existing FDA-approved ones to detect high-risk HPV genotypes in head and neck cancer specimens. The vast majority of reporting laboratories utilized LDPs. 57 KRAS and RAS family gene mutation analysis is also critical in the management of patients with non-small-cell lung cancer (NSCLC) and other tumors, 58 for which FDA approval of kits has not occurred; LDPs or off-label use of kits is required. 74, 75 The FDA approval of anti-EGFR therapies based on clinical trial outcomes data resulted in the need for clinical laboratories to test tumor tissue for the EGFR-sensitizing mutations in order for patients to be eligible for treatment. During those ground-breaking first 15 years of the targeted cancer therapy era, if the laboratory community had been prohibited from providing high-quality, standardized LDP-based testing under existing CLIA guidelines, the negative consequences to patient care in the past and the future would have been substantial. abstract: An explosion of knowledge and technology is revolutionizing medicine and patient care. Novel testing must be brought to the clinic with safety and accuracy, but also in a timely and cost-effective manner, so that patients can benefit and laboratories can offer testing consistent with current guidelines. Under the oversight provided by the Clinical Laboratory Improvement Amendments, laboratories have been able to develop and optimize laboratory procedures for use in-house. Quality improvement programs, interlaboratory comparisons, and the ability of laboratories to adjust assays as needed to improve results, utilize new sample types, or incorporate new mutations, information, or technologies are positive aspects of Clinical Laboratory Improvement Amendments oversight of laboratory-developed procedures. Laboratories have a long history of successful service to patients operating under Clinical Laboratory Improvement Amendments. A series of detailed clinical examples illustrating the quality and positive impact of laboratory-developed procedures on patient care is provided. These examples also demonstrate how Clinical Laboratory Improvement Amendments oversight ensures accurate, reliable, and reproducible testing in clinical laboratories. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528950/ doi: 10.1177/2374289517708309 id: cord-285472-cj5r3xt1 author: Kaur, Parminder title: Acute upper limb ischemia in a patient with COVID-19 date: 2020-05-13 words: 1113.0 sentences: 59.0 pages: flesch: 42.0 cache: ./cache/cord-285472-cj5r3xt1.txt txt: ./txt/cord-285472-cj5r3xt1.txt summary: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with upper and lower respiratory tract symptoms, with complications related to cytokine storm syndrome and acute respiratory distress syndrome. As per American Society of Hematology, some patients with severe coronavirus disease 2019 (COVID-19) have fulminant activation of coagulation and consumption of coagulation factors, which meets the criteria for disseminated intravascular coagulation as per International Society on Thrombosis and Haemostasis. Thus, complement inhibition may be a reasonable treatment for COVID-19-related systemic thrombosis by reducing the innate immune-mediated consequences of severe coronavirus infection [10] . In conclusion, we report a COVID-19 patient who developed arterial thrombosis leading to acute ischemia in the right upper extremity. Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia abstract: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with upper and lower respiratory tract symptoms, with complications related to cytokine storm syndrome and acute respiratory distress syndrome. It has also been described to predispose to venous and arterial thromboembolism; however, limited published data is available regarding thrombosis in coronavirus disease 2019 (COVID-19). Here we are presenting a case of arterial thrombosis in a patient with COVID-19 and a systematic review on coagulopathy associated with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32405288/ doi: 10.1016/j.hemonc.2020.05.001 id: cord-327622-ezgufe24 author: Kaur, Ramandeep title: Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date: 2020-09-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). During the SARS and MERS outbreaks, many frontline healthcare workers were infected when performing high-risk aerosol-generating medical procedures as well as when providing basic patient care. Similarly, COVID-19 disease has been reported to infect healthcare workers at a rate of ~ 3% of cases treated in the USA. In this review, we conducted an extensive literature search to develop practical strategies that can be implemented when providing respiratory treatments to COVID-19 patients, with the aim to help prevent nosocomial transmission to the frontline workers. url: https://doi.org/10.1186/s13054-020-03231-8 doi: 10.1186/s13054-020-03231-8 id: cord-024795-xa7ke70d author: Kaviani, Aaron title: Management of Antimicrobial Agents in Abdominal Organ Transplant Patients in Intensive Care Unit date: 2020-01-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: Early diagnosis of infections and immediate initiation of appropriate antimicrobials are crucial in the management of patients before and after organ transplantation. We reviewed the most recent literature and guidelines in this field and organized the current recommendations for healthcare professionals caring for critically ill organ transplant recipients. RECENT FINDINGS: The incidence of multidrug-resistant organisms is increasing. Multidrug-resistant Gram-negative bacteria comprise about 14% of organisms. Vancomycin-resistant enterococci bloodstream infections are also on the rise, as 20.5% of nosocomial enterococci are now vancomycin-resistant, changing empiric antibiotic selection. Fluconazole-resistant Candida species comprise up to 46% of cases of candidemia in hospitalized patients. Consequently, new guidelines recommend primary use of echinocandins in patients with candidemia who have moderate-to-severe disease. Finally, the incidence of emergence of ganciclovir-resistant cytomegalovirus infection in patients is 5–12%, requiring early recognition and change to alternative regimens in the case of poor response to therapy. SUMMARY: Bloodstream infections are a major cause of mortality and morbidity in solid organ transplantation. Mortality as high as 24% and 50% have been reported with sepsis and septic shock respectively. As such, bloodstream infections should be diagnosed rapidly and intravenous antibiotics should be started immediately. Appropriate resuscitation should be initiated and the number and/or dose of immunosuppressive drugs should be reduced. Proper source control must also be achieved with radiologic drainage or surgical intervention as appropriate. Initial antibiotic treatment of these patients should cover both Gram-positive organisms, especially in the presence of intravascular catheters, and Gram-negative bacteria. Echinocandins like caspofungin should also be considered especially in critically ill patients, particularly if a patient has been on total parenteral nutrition or broad-spectrum antibiotics. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222087/ doi: 10.1007/s40472-020-00268-0 id: cord-262412-bs7quwov author: Kaya, Gürkan title: Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature date: 2020-06-30 words: 3358.0 sentences: 189.0 pages: flesch: 37.0 cache: ./cache/cord-262412-bs7quwov.txt txt: ./txt/cord-262412-bs7quwov.txt summary: Clinical manifestations are as follows (see Table 1 ): generalized or localized rash (erythematous, papulovesicular, maculopapular, petechial, morbilliform, symmetrical drug-related intertriginous and flexural exanthema (SDRIFE)-like, digitate papulosquamous pityriasis rosea-like), generalized urticaria, varicelliform rash, herpes lesions (zoster), purpuric lesions (retiform purpura), livedoid lesions (livedo reticularis, livedo racemosa), acro-ischemic lesions (dry gangrene, blisters, cyanosis), erythema multiforme-like, chilblain-like lesions (COVID toes) and other lesions such as urticarial vasculitis, acute generalized exanthematous pustulosis (AGEP)-like rash, eosinophilic panniculitis, COVID mask, periorbital dyschromia, oral ulcers and COVID red half-moon nail sign. In a recent report, the postmortem histology of COVID-19 patients revealed lymphocytic endotheliitis in lung, heart, kidney, liver and small intestine, a pathological picture reminiscent of what is seen in skin lesions, suggesting that SARS-CoV-2 infection facilitates the induction of endothelial inflammation in several organs as a direct consequence of viral involvement and of host inflammatory response [61] . abstract: In recent weeks, several reports have emerged of skin lesions with different clinical presentations in COVID-19 cases. All dermatologists should be aware of these cutaneous lesions, which may be early clinical symptoms of infection. We reviewed the literature on cutaneous manifestations in the PubMed database from December 2019 and June 2020. From the cases described as case reports or series in 57 recent articles, it appears that skin lesions (i) are highly varied, (ii) may not be related to the severity of the condition and (iii) resolve spontaneously in a few days. The frequency of these lesions in COVID-19 patients varies between 1.8% and 20.4%. The major clinical forms described were maculopapular eruptions, acral areas of erythema with vesicles or pustules (pseudochilblain), urticarial lesions, other vesicular eruptions and livedo or necrosis. The lesions were mainly localized in the trunk and extremities. The majority of patients were male, aged between 4.5 and 89 years. A minority of the patients were children presenting with acral, chilblain-like lesions, papulo-vesicular eruptions or Kawasaki disease-like pediatric inflammatory multisystem syndrome. The mean duration of the lesions was a few days, but some lasting as little as 20 min and others as long as four weeks have been reported. The mean latency time in the majority of cases was between 1 and 14 days; however, in some patients, lesions appeared 2 to 5 days before the onset of COVID-19 symptoms. The histopathological features of these lesions also vary, corresponding to the diversity of clinical manifestations. These features underline the nature of epidermal and dermal vascular lesions—and in severe cases, microvascular injury and thrombosis—associated with COVID-19, and provide important clues to their pathological mechanisms. url: https://www.ncbi.nlm.nih.gov/pubmed/32608380/ doi: 10.3390/dermatopathology7010002 id: cord-010921-yzv43e8l author: Kaye, Alan David title: Dexmedetomidine in Enhanced Recovery After Surgery (ERAS) Protocols for Postoperative Pain date: 2020-04-02 words: 7253.0 sentences: 431.0 pages: flesch: 44.0 cache: ./cache/cord-010921-yzv43e8l.txt txt: ./txt/cord-010921-yzv43e8l.txt summary: As such, dexmedetomidine is now being used as part of ERAS protocols along with regional nerve blocks and other medications, to create a satisfactory postoperative outcome with reduced opioid consumption in the Post anesthesia care unit (PACU). This manuscript will comprehensively discuss dexmedetomidine with regards to postoperative pain management, ERAS protocols, pharmacokinetics, pharmacodynamics, cardiovascular and respiratory effects, toxicity, drug interactions, abuse and dependence. Analgesia with non-opioids analgesics like dexmedetomidine are being used as part of an ERAS protocol intraoperatively, along with regional nerve blocks to attain a satisfactory postoperative outcome with reduced requirements of opioids in PACU in the pediatric population. In a 2015 meta-analysis, although dexmedetomidine reduced pain intensity, opioid consumption, and postoperative nausea and vomiting (PONV), it had no effect on recovery time [29] . Postoperative pain control after the use of dexmedetomidine and propofol to sedate patients undergoing ankle surgery under spinal anesthesia: a randomized controlled trial abstract: PURPOSE OF REVIEW: Effective acute pain management has evolved considerably in recent years and is a primary area of focus in attempts to defend against the opioid epidemic. Persistent postsurgical pain (PPP) has an incidence of up to 30–50% and has negative outcome of quality of life and negative burden on individuals, family, and society. The 2016 American Society of Anesthesiologists (ASA) guidelines states that enhanced recovery after surgery (ERAS) forms an integral part of Perioperative Surgical Home (PSH) and is now recommended to use a multimodal opioid-sparing approach for management of postoperative pain. As such, dexmedetomidine is now being used as part of ERAS protocols along with regional nerve blocks and other medications, to create a satisfactory postoperative outcome with reduced opioid consumption in the Post anesthesia care unit (PACU). RECENT FINDINGS: Dexmedetomidine, a selective alpha(2) agonist, possesses analgesic effects and has a different mechanism of action when compared with opioids. When dexmedetomidine is initiated at the end of a procedure, it has a better hemodynamic stability and pain response than ropivacaine. Dexmedetomidine can be used as an adjuvant in epidurals with local anesthetic sparing effects. Its use during nerve blocks results in reduced postoperative pain. Also, local infiltration of IV dexmedetomidine is associated with earlier discharge from PACU. SUMMARY: Perioperative use of dexmedetomidine has significantly improved postoperative outcomes when used as part of ERAS protocols. An in-depth review of the use of dexmedetomidine in ERAS protocols is presented for clinical anesthesiologists. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223065/ doi: 10.1007/s11916-020-00853-z id: cord-339015-qn8wbnlw author: Kayingo, Gerald title: Bacteria and Viruses: The Bogeymen in the Intensive Care Unit date: 2019-03-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This article covers the frequently encountered bacteria and viruses in the ICU. It focuses on recognition, management, and prevention. Emerging and difficult-to-treat organisms are covered in detail. url: https://www.ncbi.nlm.nih.gov/pubmed/32289089/ doi: 10.1016/j.cpha.2018.11.003 id: cord-309395-5yan9fcn author: Kazory, Amir title: SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill date: 2020-04-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread across the globe, and millions of people may be affected. While knowledge regarding epidemiologic features and diagnostic tools of coronavirus disease 2019 (COVID-19) is rapidly evolving, uncertainties surrounding various aspects of its optimal management strategies persist. A subset of these patients develop a more severe form of the disease characterized by expanding pulmonary lesions, sepsis, acute respiratory distress syndrome, and respiratory failure. Due to lack of data on treatment strategies specific to this subset of patients, currently available evidence on management of the critically ill needs to be extrapolated and customized to their clinical needs. The article calls attention to fluid stewardship in the critically ill with COVID-19 by judiciously applying the evidence-based resuscitation principles to their specific clinical features such as high rates of cardiac injury. As we await more data from treating these patients, this strategy is likely to help reduce potential complications. url: https://doi.org/10.1080/08998280.2020.1754700 doi: 10.1080/08998280.2020.1754700 id: cord-294073-65h2mkdy author: Ke, Jia title: Strategies and recommendations for the management of gastrointestinal surgery during the COVID-19 pandemic: experience shared by Chinese surgeons date: 2020-07-03 words: 4150.0 sentences: 234.0 pages: flesch: 43.0 cache: ./cache/cord-294073-65h2mkdy.txt txt: ./txt/cord-294073-65h2mkdy.txt summary: We also recommend that each hospital should establish a group of diagnostic experts with responsibilities for risk stratification, especially for patients under investigation who need urgent surgery. • It is known that fever is one of the most common symptoms of COVID-19 and that patients with certain GI diseases (e.g. acute appendicitis, gastric perforation, intestinal obstruction) who required urgent care with emergency GI surgery often present with high fever as well. COVID-19-positive patients with GI bleeding with hemodynamic stability should undergo conservative treatments first, including angioembolization, before endoscopic treatment due to the high risk of endoscopy being an aerosol-generating procedure. For confirmed/high-risk COVID-19 patients and PUIs, diagnostic and therapeutic GI endoscopies should be performed in a negative-pressure room with Level Three precautions. For all surgical personnel involved in GI surgery for confirmed/ high-risk COVID-19 patients or for PUIs for COVID-19, we recommend the following protective measures (Figure 1 ). abstract: Novel coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing public-health pandemic worldwide. Although SARS-CoV-2 has been known to spread primarily through respiratory droplets, recent evidence also supports fecal/oral as an additional route of transmission, raising concerns over gastrointestinal (GI) transmission of the infection. Herein, we, as the front-line Chinese GI surgeons, would like to share our experience and lessons in the combat against COVID-19. It is essential to create science-based, rational, and practical strategies during the outbreak of COVID-19. Here, we provide multi-institutional consensus on minimizing disease transmission while continuing to provide care from all aspects for patients in GI surgery, including outpatient clinics, inpatient units, gastrointestinal endoscopy centers, and adjustments in perioperative care. Our experiences and recommendations are worth sharing and may help to establish specific infection-control and outcome measures. url: https://www.ncbi.nlm.nih.gov/pubmed/32661490/ doi: 10.1093/gastro/goaa030 id: cord-347293-fp8phk0p author: Kearns, Donovan G. title: Assessing The Risk of Adalimumab Use For Hidradenitis Suppurativa During The COVID-19 Pandemic date: 2020-07-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S0190962220322878 doi: 10.1016/j.jaad.2020.07.086 id: cord-348813-v1sdodz9 author: Kefale, Belayneh title: Prevalence and Risk Factors of Thromboembolism among Patients With Coronavirus Disease-19: A Systematic Review and Meta-Analysis date: 2020-10-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Emerging evidence shows that the recent pandemic of coronavirus disease 19 (COVID-19) is characterized by coagulation activation and endothelial dysfunction. This increases the risk of morbidity, mortality and economic loss among COVID-19 patients. Therefore, there was an urgent need to investigate the extent and risk factors of thromboembolism among COVID-19 patients. English-language based databases (PubMed, Cumulative Index to Nursing and Allied Health Literature, EMBASE, and Cochrane library) were exhaustively searched to identify studies related to prevalence of thromboembolism among hospitalized COVID-19 patients. A random-effects model was employed to estimate the pooled prevalence of thromboembolism. The pooled prevalence of thrombotic events was computed using STATA 16.0 software. Heterogeneity analysis was reported using I(2). A total of 19 studies with 2,520 patients with COVID-19 were included. The pooled prevalence of thrombotic events of hospitalized patients with COVID-19 was 33% (95% CI: 25-41%, I(2) = 97.30%, p < 0.001) with a high degree of heterogeneity across studies. Elevated D-dimer hospitalized in the intensive care unit and being under mechanical ventilation were the most frequently associated factors for the development of thrombotic events. The pooled prevalence of thrombotic events in COVID-19 patients was 33%. The prevalence of thrombotic event is variables on the basis of study design and study centers. Several risk factors such as, elevated D-dimer, hospitalized in the intensive care unit and being under mechanical ventilation, were the most frequently reported risk factors identified. Therefore, healthcare professionals should consider these risk factors to optimally manage thromboembolism in COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33074717/ doi: 10.1177/1076029620967083 id: cord-353599-cw29edwr author: Kelleni, Mina T. title: Early use of Non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The pathogenesis of Coronavirus disease 2019 is still obscure and the need for exploration of possible mechanisms to suggest drugs based on knowledge should never be delayed. In this manuscript, we present a novel theory to explain the pathogenesis of COVID-19; lymphocyte distraction theory upon which the author has used, in a preprinted protocol, non-steroidal anti-inflammatory drugs (NSAIDs); diclofenac potassium, ibuprofen and ketoprofen, successfully to treat COVID-19 patients. Furthermore, we agree with a recommendation that glucocorticoids should not be used routinely for COVID-19 patients and suggested to be beneficial only for patients with late acute respiratory distress syndrome. A clinical proof of ibuprofen safety in COVID-19 has been published by other researchers and we suggest that early administration of NSAIDs, including ibuprofen, in COVID-19 is not only safe but it might also prevent COVID-19 complications and this manuscript explains some of the suggested associated protective mechanisms. url: https://api.elsevier.com/content/article/pii/S0753332220311744 doi: 10.1016/j.biopha.2020.110982 id: cord-336488-opjjowcq author: Kenanidis, Eustathios title: Organizing an Orthopaedic Department During COVID-19 Pandemic to Mitigate In-Hospital Transmission: Experience From Greece date: 2020-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerging in Wuhan city of China, was the cause of a rare type of pneumonia evolving rapidly in pandemic early at the beginning of 2020. The rapid human-to-human transmission of SARS-CoV-2 increases the risk of in-hospital transmission, requiring re-definement of musculoskeletal trauma management and postoperative care. Following the review of the existing literature on COVID-19 and similar infectious diseases, National and Hospital Board instructions for Infectious Diseases, as well as the consensus for surgical care by the consortium of the Orthopaedic Department Directors, we present the outline of the implemented principles in the orthopaedic departments of a tertiary academic hospital in Greece to operate during COVID-19 pandemic. Our overall objectives were to decrease the admission load and mitigate the risk of in-hospital transmission of SARS-CoV-2. The principles involve the management of the Orthopaedic medical and nursing personnel, alterations of the workflow in the wards, operating rooms and outpatient clinics from the admission to the discharge of an orthopaedic patient. In addition, we present the recommended principles of management of traumatic orthopaedic injuries highlighting those deserving admission and in-hospital care and those that can be treated in the outpatient setting or day surgery clinics. url: https://doi.org/10.7759/cureus.8676 doi: 10.7759/cureus.8676 id: cord-330676-urr9oqfc author: Keny, Dr Swapnil title: Emergency and Urgent Orthopaedic Surgeries in non covid patients during the COVID 19 pandemic: Perspective from India date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To Evaluate the results and the protocols of our Institution for 18 Emergency and Urgent Non Covid Surgeries during the Covid 19 Pandemic METHODS: 18 patients underwent Emergency and Urgent Orthopaedic Surgeries at institution. The Protocol was Screening, Segregation, Selection, Isolation, theatre modification, and Online Follow. RESULTS: Two adverse events including, one death and one intensive care admission due to underlying morbidity were recorded. Average Hospital stay was 2.5 days with no patients becoming covid positive at follow up. CONCLUSION: Strict Surgical protocols need to be followed for surgery during the Covid19 pandemic. url: https://www.sciencedirect.com/science/article/pii/S0972978X20301914?v=s5 doi: 10.1016/j.jor.2020.05.012 id: cord-256290-pyrmtps3 author: Kerr, Colm title: Prevalence of smell and taste dysfunction in a cohort of CoVID19 outpatients managed through remote consultation from a large urban teaching hospital in Dublin, Ireland date: 2020-07-15 words: 1348.0 sentences: 85.0 pages: flesch: 57.0 cache: ./cache/cord-256290-pyrmtps3.txt txt: ./txt/cord-256290-pyrmtps3.txt summary: Assessment of smell and taste function should be conducted at the point of CoVID19 testing to further investigate their association with disease presence. At the time of our study, The European Centre for Disease Prevention and Control did not specifically delineate taste and smell disturbances as features of CoVID19. As such, our study investigated the prevalence of these features in a cohort of newly diagnosed COVID19 patients triaged to management in an outpatient setting through a telephone clinic. Our study has found that, in a cohort of patients with confirmed mild CoVID19 disease suitable for remote medical management, approximately half of them experienced new onset smell or taste dysfunction. Further work should also investigate the prevalence of olfactory and gustatory disturbance in all patients being tested for CoVID19, in order to evaluate the diagnostic value of these features in predicting the presence of the disease. abstract: Summary In our cohort of CoVID19 positive outpatients, approximately half experienced smell and taste dysfunction. Younger patients were more likely to experience olfactory sense loss than older patients. Assessment of smell and taste function should be conducted at the point of CoVID19 testing to further investigate their association with disease presence. url: https://api.elsevier.com/content/article/pii/S2590088920300408 doi: 10.1016/j.infpip.2020.100076 id: cord-327818-1abweqko author: Kersebaum, Dilara title: The early influence of COVID-19 pandemic-associated restrictions on pain, mood, and everyday life of patients with painful polyneuropathy date: 2020-10-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The SARS-Cov-2 pandemic requires special attention on its psychological effects and the impact on patients with chronic pain. OBJECTIVES: This study aimed at examining the influence of the COVID-19 pandemic-associated regulations initiated by the German government on pain intensity and characteristics, emotional well-being, and everyday life of patients with painful polyneuropathy. METHODS: Forty-three patients (well assessed with questionnaires before the pandemic and without change of their health status between baseline and current assessment) were investigated with validated, self-reported questionnaires and COVID-19-specific items 2 weeks after the regulations came into effect. RESULTS: Pain intensity remained stable or even improved like the neuropathic pain symptom inventory total score (t0: 33.54 ± 20.48 vs t1: 27.38 ± 16.16, P = 0.008). Only 11.6% reported a pandemic-associated pain worsening. Rumination scores of the Pain Catastrophizing Scale were lower during t1 compared to before the pandemic regulations (t0: 7.81 ± 4.70, t1: 6.49 ± 4.39; P = 0.030). Interestingly, pain ratings for the last 7 days were higher in patients with a changed social life compared to those without (−1.63 ± 1.60 vs 0.31 ± 1.83; P = 0.01). Quality of life was decreased and helplessness increased in those with higher pain ratings. CONCLUSION: Results suggest a shift of attention from the chronic pain condition towards the imminent threat of a global pandemic. As the impacts of the pandemic are persistent and evolving, the development of the measured parameters in the forthcoming weeks will be of great interest. url: https://doi.org/10.1097/pr9.0000000000000858 doi: 10.1097/pr9.0000000000000858 id: cord-011975-8vl45xb7 author: Keser, Tobias title: Risk Factors for Dysphagia and the Impact on Outcome After Spontaneous Subarachnoid Hemorrhage date: 2019-11-15 words: 3806.0 sentences: 195.0 pages: flesch: 41.0 cache: ./cache/cord-011975-8vl45xb7.txt txt: ./txt/cord-011975-8vl45xb7.txt summary: BACKGROUND: Despite the tremendous impact of swallowing disorders on outcome following ischemic stroke, little is known about the incidence of dysphagia after subarachnoid hemorrhage (SAH) and its contribution to hospital complications, length of intensive care unit stay, and functional outcome. The main goal of the current study was (1) to quantify the rate of swallowing disorders after SAH by using a simple clinical assessment tool, (2) to identify early predictors of dysphagia in all severity grades of SAH patients, and (3) to evaluate how dysphagia contributes to hospital complications, length of ICU stay, and poor outcome. CT computed tomography, EVD external ventricular drain, ICU intensive care unit, IQR interquartile range Statistical analysis was performed using the Wilcoxon rank-sum test (*), the Chi-square test ( †), and the linear-by-linear association test for trend ( ‡) Although it is well known that the high incidence of swallowing disorders after ischemic stroke contributes to impaired quality of life and poor functional outcome, only few studies report the incidence of dysphagia following SAH [9, 10] . abstract: BACKGROUND: Despite the tremendous impact of swallowing disorders on outcome following ischemic stroke, little is known about the incidence of dysphagia after subarachnoid hemorrhage (SAH) and its contribution to hospital complications, length of intensive care unit stay, and functional outcome. METHODS: This is a retrospective analysis of an ongoing prospective cohort study. Swallowing ability was assessed in consecutive non-traumatic SAH patients admitted to our neurological intensive care unit using the Bogenhausen Dysphagia Score (BODS). A BODS > 2 points indicated dysphagia. Functional outcome was assessed 3 months after the SAH using the modified Rankin Scale with a score > 2 defined as poor functional outcome. RESULTS: Two-hundred and fifty consecutive SAH patients comprising all clinical severity grades with a median age of 57 years (interquartile range 47–67) were eligible for analysis. Dysphagia was diagnosed in 86 patients (34.4%). Factors independently associated with the development of dysphagia were poor clinical grade on admission (Hunt & Hess grades 4–5), SAH-associated parenchymal hematoma, hydrocephalus, detection of an aneurysm, and prolonged mechanical ventilation (> 48 h). Dysphagia was independently associated with a higher rate of pneumonia (OR = 4.32, 95% CI = 2.35–7.93), blood stream infection (OR = 4.3, 95% CI = 2.0–9.4), longer ICU stay [14 (8–21) days versus 29.5 (23–45) days, p < 0.001], and poor functional outcome after 3 months (OR = 3.10, 95% CI = 1.49–6.39). CONCLUSIONS: Dysphagia is a frequent complication of non-traumatic SAH and associated with poor functional outcome, infectious complications, and prolonged stay in the intensive care unit. Early identification of high-risk patients is needed to timely stratify individual patients for dysphagia treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12028-019-00874-6) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392368/ doi: 10.1007/s12028-019-00874-6 id: cord-331827-amg309uz author: Keske, Şiran title: Human metapneumovirus infection: Diagnostic impact of radiologic imaging date: 2019-02-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Human metapneumovirus (hMPV) is a recently detected virus, which can cause mild to severe respiratory tract infections. Through this study, we aimed to detail the outcomes of hMPV infections. MATERIALS/METHODS: Between January 2012 and November 2017, patients who had hMPV detected in nasopharyngeal or bronchoalveolar lavage by molecular respiratory pathogen tests were evaluated. The Food and Drug Administration cleared multiplexed‐polymerase chain reaction system (Idaho Technology, Salt Lake City, UT) was used for diagnosis. Chest radiography (CR) and computed tomography (CT) were evaluated by an expert radiologist. RESULTS: In total 100 patients were included, the mean age was 22.9 (0‐87) years, and 50% were male. The hospitalization rate was 52%. Lower respiratory system infection (LRTI) was diagnosed in 44 patients with clinical findings, and in 31 patients out of 44 the radiological findings supported the diagnosis. The LRTI rate was significantly higher in adults than children (66.7%‐32.8%; P = 0.001). In CR, peribronchovascular infiltration (PI) was the most common feature seen in 14 out of 18 patients and was generally bilateral (13 out of 18 patients). In CT imaging, ground‐glass opacity was the most common finding seen in 11 out of 16 patients and nodular consolidation in five patients. Ribavirin was given to four patients, three of whom were severe and required respiratory support. None of the patients died of hMPV infection. CONCLUSIONS: The ground‐glass opacity in CT was similar to other respiratory virus infections, and PI in CR was very common and typical; however, nodular consolidation that may mimic bacterial infection was seen in one‐fourth of CT. url: https://doi.org/10.1002/jmv.25402 doi: 10.1002/jmv.25402 id: cord-255240-ltatgq3e author: Kesserwani, Hassan title: Cerebral Microbleeds - To Treat or Not to Treat, That Is the Question: A Case Report With a Note on Its Radiologic Deconstruction and Therapeutic Nuances date: 2020-09-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: With the ubiquity of susceptibility weighted imaging (SWI), cerebral microbleeds (CMBs) are fast becoming a prevalent phenomenon. They are tightly associated with age, neurodegeneration and diverse vascular etiologies. CMBs have a unique radiological signature. Their morphology, number and topology are quite informative. They also pose a therapeutic conundrum, as they are associated with the risk of cerebral hemorrhage. We present the case of an 86-year-old woman who has a vascular dementia, Binswanger's syndrome, and coronary artery disease, who presented with more than five CMBs. We present this case in order to highlight the dilemma of anti-platelet therapy in this group of patients and we demonstrate the cardinal radiologic features of CMBs. We then segue into the pathologic correlates of CMBs and associated risk factors. We finally analyze the risk of anti-platelet therapy in the presence of CMBs, and we unfold the latest data on CMB number and anti-platelet therapy. url: https://www.ncbi.nlm.nih.gov/pubmed/33101796/ doi: 10.7759/cureus.10548 id: cord-315490-xs5v3uc3 author: Kessler, Remi A. title: Neurosurgical management of brain and spine tumors in the COVID-19 era: an institutional experience from the epicenter of the pandemic date: 2020-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The challenges of neurosurgical patient management and surgical decision-making during the 2019–2020 COVID-19 worldwide pandemic are immense and never-before-seen in our generation of neurosurgeons. In this case-based formatted report, we present the Mount Sinai Hospital (New York, NY) Department of Neurosurgery institutional experience in the epicenter of the pandemic and the guiding principles for our current management of intracranial, skull base, and spine tumors. The detailed explanations of our surgical reasoning for each tumor case is tailored to assist neurosurgeons across the United States as they face these complex operative decisions put forth by the realities of the pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32372178/ doi: 10.1007/s11060-020-03523-7 id: cord-267621-oc8bw7ft author: Kevorkian, Jean-Philippe title: Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study date: 2020-09-01 words: 1196.0 sentences: 82.0 pages: flesch: 37.0 cache: ./cache/cord-267621-oc8bw7ft.txt txt: ./txt/cord-267621-oc8bw7ft.txt summary: title: Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study 5 Therefore, to address the effectiveness of early short-course corticosteroid/furosemide treatment in the non-critically ill COVID-19 patient, we designed a retrospective observational cohort study. In the corticosteroid/furosemide treatment group, incidence of invasive MV or death given once daily for up to ten days reduced 28-day mortality by one-third among mechanically ventilated COVID-19 patients and by one-fifth among patients treated with oxygen, while no benefit was observed in patients not receiving respiratory support at randomization. To conclude, our data provides evidence that early short-course of corticosteroids combined to furosemide reduces the risk of invasive MV requirement or 28-day mortality in the non-critically ill COVID-19 patients. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32888976/ doi: 10.1016/j.jinf.2020.08.045 id: cord-284038-93s3ffoy author: Keyhanian, Kiandokht title: SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation date: 2020-11-07 words: 11701.0 sentences: 592.0 pages: flesch: 42.0 cache: ./cache/cord-284038-93s3ffoy.txt txt: ./txt/cord-284038-93s3ffoy.txt summary: Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. Growing number of case reports and/or series indicate that a variety of neurological conditions and post-viral triggered autoimmune complications, as we discuss below, occur in association with SARS-CoV-2 infection which mainly include Guillain-Barré syndromes (GBSs) (table 2), myopathy and rhabdomyolysis (table 2) , encephalopathy, meningoencephalitis, encephalomyelitis, and myelitis (table 3) . Moreover, two cases of acute necrotizing encephalopathy (ANE) in patients with COVID-19 positivity from nasopharyngeal and oropharyngeal swab, but without CSF PCR for SARS-CoV-2 data, were reported in the literature (Poyiadji, Shahin, 2020 , Radmanesh et al. abstract: Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide. url: https://www.sciencedirect.com/science/article/pii/S0165572820306974?v=s5 doi: 10.1016/j.jneuroim.2020.577436 id: cord-253862-jl1zhg13 author: Khalaf, Khalil title: SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment date: 2020-10-06 words: 14595.0 sentences: 760.0 pages: flesch: 45.0 cache: ./cache/cord-253862-jl1zhg13.txt txt: ./txt/cord-253862-jl1zhg13.txt summary: Although this novel virus is less severe than the first SARS-CoV outbreak, human-to-human transmission remains very high and the number of cases continues to rise exponentially in major urban areas, highlighting the urgent need to develop new containment, diagnostic, and treatment protocols. In the case of SARS-CoV-2, viral evasion of the innate immune system leads to an increase in cytokine production and late CD4+/CD8+ response, which then leads to pathogenic inflammation in patients with high viral loads. (ChiCTR2000029308), involving severe SARS-CoV-2 cases, compared lopinavir/ritonavir treatment with standard care alone, and they showed that the antivirals yielded no clinical benefits. In an open-label control study conducted by Cai et al., the antiviral activity of favipiravir + IFN-α was compared to that of lopinavir/ritonavir + IFN-α in patients with confirmed SARS-CoV-2 infection. abstract: The emergence and rapid spread of SARS-CoV-2 in December 2019 has brought the world to a standstill. While less pathogenic than the 2002–2003 SARS-CoV, this novel betacoronavirus presents a global threat due to its high transmission rate, ability to invade multiple tissues, and ability to trigger immunological hyperactivation. The identification of the animal reservoir and intermediate host were important steps toward slowing the spread of disease, and its genetic similarity to SARS-CoV has helped to determine pathogenesis and direct treatment strategies. The exponential increase in cases has necessitated fast and reliable testing procedures. Although RT-PCR remains the gold standard, it is a time-consuming procedure, paving the way for newer techniques such as serologic tests and enzyme immunoassays. Various clinical trials using broad antiviral agents in addition to novel medications have produced controversial results; however, the advancement of immunotherapy, particularly monoclonal antibodies and immune modulators is showing great promise in clinical trials. Non-orthodox medications such as anti-malarials have been tested in multiple institutions but definitive conclusions are yet to be made. Adjuvant therapies have also proven to be effective in decreasing mortality in the disease course. While no formal guidelines have been established, the multitude of ongoing clinical trials as a result of unprecedented access to research data brings us closer to halting the SARS-CoV-2 pandemic. url: https://doi.org/10.3389/fimmu.2020.570927 doi: 10.3389/fimmu.2020.570927 id: cord-318694-370ccaoc author: Khanna, Niharika title: Utilizing the Learning Health System Adaptation to guide Family Medicine Practice to COVID-19 response date: 2020-10-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 supportive quarantine care in the community is managed by primary care practices. There is no current guidance on how a primary care practice with high volumes of patients screened for COVID-19 can re-configure itself to become responsive to the pandemic. We examined Learning Health System guidance from the National Academies of Science, Engineering and Medicine and adapted it to our primary care practice to create an efficient, effective, adaptive response to the COVID-19 pandemic. We suggest evaluating this response in the future for effectiveness and efficiency. url: https://doi.org/10.1177/2150132720966409 doi: 10.1177/2150132720966409 id: cord-302448-2r4rtixg author: Kharma, Nadir title: Anticoagulation in critically ill patients on mechanical ventilation suffering from COVID-19 disease, The ANTI-CO trial: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To assess the effect of anticoagulation with bivalirudin administered intravenously on gas-exchange in patients with COVID-19 and respiratory failure using invasive mechanical ventilation. TRIAL DESIGN: This is a single centre parallel group, superiority, randomized (1:1 allocation ratio) controlled trial. PARTICIPANTS: All patients admitted to the Hamad Medical Corporation -ICU in Qatar for COVID-19 associated respiratory distress and in need of mechanical ventilation are screened for eligibility. Inclusion criteria: all adult patients admitted to the ICU who test positive for COVID-19 by PCR-test and in need for mechanical ventilation are eligible for inclusion. Upon crossing the limit of D-dimers (1.2 mg/L) these patients are routinely treated with an increased dose of anticoagulant according to our local protocol. This will be the start of randomization. Exclusion criteria: pregnancy, allergic to the drug, inherited coagulation abnormalities, no informed consent. INTERVENTION AND COMPARATOR: The intervention group will receive the anticoagulant bivalirudin intravenously with a target aPTT of 45-70 sec for three days while the control group will stay on the standard treatment with low-molecular-weight heparins /unfractionated heparin subcutaneously (see scheme in Additional file 1). All other treatment will be unchanged and left to the attending physicians. MAIN OUTCOMES: As a surrogate parameter for clinical improvement and primary outcome we will use the PaO2/FiO2 (P/F) ratio. RANDOMISATION: After inclusion, the patients will be randomized using a closed envelope method into the conventional treatment group, which uses the standard strategy and the experimental group which receives anticoagulation treatment with bivalirudin using an allocation ratio of 1:1. BLINDING (MASKING): Due to logistical and safety reasons (assessment of aPTT to titrate the study drug) only the data-analyst will be blinded to the groups. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): We performed a sample size calculation and assumed the data for P/F ratio (according to literature) is normally distributed and used the mean which would be: 160 and SD is 80. We expect the treatment will improve this by 30%. In order to reach a power of 80% we would need 44 patients per group (in total 88 patients). Taking approximately 10% of dropout into account we will include 100 patients (50 in each group). TRIAL STATUS: The local registration number is MRC-05-082 with the protocol version number 2. The date of approval is 18th June 2020. Recruitment started on 28(th) June and is expected to end in November 2020. TRIAL REGISTRATION: The protocol is registered before starting subject recruitment under the title: “Anticoagulation in patients suffering from COVID-19 disease. The ANTI-CO Trial” in ClinicalTrials.org with the registration number: NCT04445935. Registered on 24 June 2020. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 2). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://doi.org/10.1186/s13063-020-04689-1 doi: 10.1186/s13063-020-04689-1 id: cord-277643-xh8z9v0m author: Khatiwada, Asmita Priyadarshini title: Paradigm shift of drug information centers during the COVID-19 pandemic date: 2020-07-20 words: 3930.0 sentences: 184.0 pages: flesch: 38.0 cache: ./cache/cord-277643-xh8z9v0m.txt txt: ./txt/cord-277643-xh8z9v0m.txt summary: Pharmacists played a crucial role in direct patient care, medication information, and proper drug distribution with proactive communication among themselves and with other HCPs during the severe acute respiratory syndrome (SARS) pandemic. However, new roles including immunization, contraception, public awareness, identifying infected patients and redirecting them to hospitals and isolation centers, logistics, supplies and clinical management, and being an information hub for patients and HCPs regarding the disease, transmission, preventive measures, management approaches, and investigational medications were identified [14, 15] . Even though the various services provided by the pharmacists during different pandemics were not directly through DICs, pharmacists were actively involved in the dissemination of information on the disease and investigational World Health Organization (WHO)-approved/non-approved medications to the patients, HCPs and the public. Detailed information on COVID-19 and its effects in patients with various health conditions, such as cardiovascular disease (CVD), diabetes mellitus, neurological issues, and respiratory illnesses, can be disseminated to HCPs and patients/ public via DICs, thereby promoting the role of pharmacists in patient management. abstract: The novel coronavirus disease 2019 (COVID-19) pandemic is a major global threat affecting millions of lives throughout the world physically and psychologically. With the asymptomatic presentation of COVID-19 in many patients and the similarity of its symptoms with the common cold and influenza, the need for accurate information on the disease is very important for its identification and proper management. Accurate information on the disease, its prevention and treatment can be disseminated through drug information centers (DICs). DICs are usually staffed by pharmacists and/or clinical pharmacists/pharmacologists. DICs are a reliable source of current and unbiased information on COVID-19 and its associated complications, including management options for healthcare professionals and the public. In addition to health and drug information, pharmacists working in the DICs can be involved in the management of the patients’ health by providing information on home care and safety, medication management of patients with chronic comorbid illnesses, and psychological advice. This article explores the possible additional roles DICs can play, besides providing drug information within the hospital or in the community. url: https://www.ncbi.nlm.nih.gov/pubmed/32837192/ doi: 10.1007/s40267-020-00757-3 id: cord-342068-zhk3wmou author: Khazanie, Prateeti title: Forced Choices: Ethical Challenges in Cardiology During the COVID-19 Pandemic date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32392096/ doi: 10.1161/circulationaha.120.047681 id: cord-270153-krhkqcev author: Khosla, Seema title: Implementation of Synchronous Telemedicine into Clinical Practice date: 2020-08-04 words: 5447.0 sentences: 365.0 pages: flesch: 61.0 cache: ./cache/cord-270153-krhkqcev.txt txt: ./txt/cord-270153-krhkqcev.txt summary: Synchronous telemedicine allows clinicians to expand their reach by using technology to take care of patients who otherwise may not be seen. If the clinician is planning to transition current in-person patients to a telemedicine model, or if it has been determined that there is room in the clinic schedule, the next step is to assess the financial feasibility of a telemedicine practice. It is vital to take the time to create an appropriate clinical experience for both the patient and the clinician, which involves setting up the environment and paying attention to specific details that will allow the clinician to execute a successful telemedicine encounter. 26 Clinicians are able to reach patients who would otherwise never be seen by using telemedicine technology. Many of these health care consumers also expect to be able to have a face-to-face visit with their clinicians on demand in the convenience of their homes or places of work. abstract: Synchronous telemedicine allows clinicians to expand their reach by using technology to take care of patients who otherwise may not be seen. Establishing a telemedicine practice can be daunting. This article outlines how to implement a synchronous telemedicine practice into an existing workflow. Telemedicine-specific considerations are discussed, as well as guidance regarding practice assessment, financial feasibility, technical considerations, and clinical guidance to translate in-person visit skills into an effective virtual visit. url: https://api.elsevier.com/content/article/pii/S1556407X20300424 doi: 10.1016/j.jsmc.2020.05.002 id: cord-309236-p4c2d5y3 author: Khurram, Ruhaid title: Spontaneous tension pneumothorax and acute pulmonary emboli in a patient with COVID-19 infection date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has had a significant impact on the structure and operation of healthcare services worldwide. We highlight a case of a 64-year-old man who presented to the emergency department with acute dyspnoea on a background of a 2-week history of fever, dry cough and shortness of breath. On initial assessment the patient was hypoxic (arterial oxygen saturation (SaO(2)) of 86% on room air), requiring 10 L/min of oxygen to maintain 98% SaO(2). Examination demonstrated left-sided tracheal deviation and absent breath sounds in the right lung field on auscultation. A chest radiograph revealed a large right-sided tension pneumothorax which was treated with needle thoracocentesis and a definitive chest drain. A CT pulmonary angiogram demonstrated segmental left lower lobe acute pulmonary emboli, significant generalised COVID-19 parenchymal features, surgical emphysema and an iatrogenic pneumatocoele. This case emphasises the importance of considering coexisting alternative diagnoses in patients who present with suspected COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32784238/ doi: 10.1136/bcr-2020-237475 id: cord-285867-61y4aamj author: Kichloo, Asim title: Atezolizumab-Induced Bell’s Palsy in a Patient With Small Cell Lung Cancer date: 2020-10-13 words: 1973.0 sentences: 124.0 pages: flesch: 43.0 cache: ./cache/cord-285867-61y4aamj.txt txt: ./txt/cord-285867-61y4aamj.txt summary: Neurotoxicity is a rare complication of immune checkpoint inhibitor therapy, and facial palsy as a complication of atezolizumab therapy has only been reported in one additional study. We present the case of a 68-year-old female with a history of small cell carcinoma of the lung presenting with sudden-onset facial palsy and numbness of the distal extremities in the setting of receiving atezolizumab immunotherapy. Clinicians should be aware of this rare adverse effect in order to enact early management including temporary cessation of therapy to prevent morbidity in patients undergoing immunotherapy. 10 Facial palsy secondary to immune checkpoint inhibitor therapy is rare, occurring in only 5 of 364 patients in one retrospective study. Facial palsy is a rare side effect of immune checkpoint inhibitor therapy with atezolizumab. The diagnosis of facial palsy secondary to immune checkpoint inhibitor therapy is one of exclusion, and clinicians should be aware of this as a potential adverse event. abstract: Immune checkpoint inhibitors are rapidly becoming popular therapeutic options for patients suffering from a number of malignancies. Atezolizumab is a programmed cell death ligand-1 inhibitor, and binding to this ligand decreases the ability of tumor cells to evade the immune system, resulting in self-tolerance. While inhibition of these molecules leads to increased T-cell destruction of tumor cells, it also may lead to autoimmune destruction of healthy cells. Neurotoxicity is a rare complication of immune checkpoint inhibitor therapy, and facial palsy as a complication of atezolizumab therapy has only been reported in one additional study. We present the case of a 68-year-old female with a history of small cell carcinoma of the lung presenting with sudden-onset facial palsy and numbness of the distal extremities in the setting of receiving atezolizumab immunotherapy. Our patient was managed with temporary cessation of her immunotherapy, oral prednisone, and supportive measures. Within 4 weeks, the patient had complete resolution of her facial palsy and was able to resume immunotherapy without further complication. Clinicians should be aware of this rare adverse effect in order to enact early management including temporary cessation of therapy to prevent morbidity in patients undergoing immunotherapy. url: https://doi.org/10.1177/2324709620965010 doi: 10.1177/2324709620965010 id: cord-023833-xpfibjh2 author: Kilickaya, O. title: Structured Approach to Early Recognition and Treatment of Acute Critical Illness date: 2014 words: 3386.0 sentences: 164.0 pages: flesch: 36.0 cache: ./cache/cord-023833-xpfibjh2.txt txt: ./txt/cord-023833-xpfibjh2.txt summary: Embracing a safety culture, limiting the number of steps (''less is more''), enhancing and prompting clear prioritized information, patient-and familycentered care delivery (integration of values, beliefs and advanced directives), improved communication and coordination (hand-offs, physician extenders) are all needed for safe and efficient critical care delivery. The advances in information technology, medical informatics and human factors engineering, have provided a tremendous opportunity for the development of novel and user-friendly checklists and decision support tools that can be widely applied in a complex and busy acute care settings [9] . To be successful, these applications need to reduce information overload and the potential for error, facilitate adherence to practice guidelines and enable clear communication and collaborative decision Fig. 3 Outline of the structured approach to early recognition and treatment of acute illness. A structured, reliable and error-free approach to the management of acutely ill or injured patients during the early, most vulnerable period is facilitated by point-of-care checklists and algorithms containing brief prioritized information. abstract: Well-known global health priorities (malaria, pneumonia, sepsis, diarrhea, human immunodeficiency virus [HIV], tuberculosis, trauma), although very different threats to an individual’s health, share a common consequence: Development of acute, life-threatening illness. In the developed world, such illness is routinely treated in an intensive care unit (ICU) by highly specialized physicians, nurses and support staff. This model of intensive care is spreading rapidly to low and middle income countries and as it spreads, challenges and limitations to this model arise [1]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176179/ doi: 10.1007/978-3-319-03746-2_51 id: cord-280551-9hoxy5ok author: Kim, Donghee title: Predictors of Outcomes of COVID-19 in Patients with Chronic Liver Disease: US Multi-center Study date: 2020-09-17 words: 3585.0 sentences: 189.0 pages: flesch: 49.0 cache: ./cache/cord-280551-9hoxy5ok.txt txt: ./txt/cord-280551-9hoxy5ok.txt summary: We performed survival analysis to identify independent predictors of all-cause mortality and COVID-19 related mortality, and multivariate logistic regression to determine the risk of severe COVID-19 in patients with CLD. The liver-specific factors associated with independent risk of higher overall mortality were alcohol-related liver disease (ALD) (hazard ratio [HR] 2.42, 95% confidence interval [CI] 1.29-4.55), decompensated cirrhosis (HR 2.91 [1.70-5.00]) and hepatocellular carcinoma (HCC) (HR 3.31 [1.53-7.16]). Future studies will be needed to analyze specific subgroups within the spectrum of alcohol liver disease (ALD) who are at higher risk for adverse outcomes with COVID-19. We identify decompensated cirrhosis, ALD, and HCC to be determinants of mortality in patients with CLD, and additionally show that Hispanic ethnicity is independently associated with severe COVID-19. In this large study of 867 patients from 21 centers across the US with CLD with COVID-19 we determine that patients with alcohol related liver disease (ALD), decompensated cirrhosis and hepatocellular carcinoma have a high risk for allcause mortality from COVID-19. abstract: Background Chronic liver disease (CLD) represents a major global health burden. We undertook this study to identify the factors associated with adverse outcomes in patients with CLD who acquire the novel coronavirus-2019 (COVID-19). Methods We conducted a multi-center, observational cohort study across 21 institutions in the United States (US) of adult patients with CLD and laboratory-confirmed diagnosis of COVID-19 between March 1, 2020 and May 30, 2020. We performed survival analysis to identify independent predictors of all-cause mortality and COVID-19 related mortality, and multivariate logistic regression to determine the risk of severe COVID-19 in patients with CLD. Results Of the 978 patients in our cohort, 867 patients (mean age 56.9±14.5 years, 55% male) met inclusion criteria. The overall all-cause mortality was 14.0% (n = 121), and 61.7% (n = 535) had severe COVID-19. Patients presenting with diarrhea or nausea/vomiting were more likely to have severe COVID-19. The liver-specific factors associated with independent risk of higher overall mortality were alcohol-related liver disease (ALD) (hazard ratio [HR] 2.42, 95% confidence interval [CI] 1.29-4.55), decompensated cirrhosis (HR 2.91 [1.70-5.00]) and hepatocellular carcinoma (HCC) (HR 3.31 [1.53-7.16]). Other factors were increasing age, diabetes, hypertension, chronic obstructive pulmonary disease and current smoker. Hispanic ethnicity (odds ratio [OR] 2.33 [1.47-3.70]) and decompensated cirrhosis (OR 2.50 [1.20-5.21]) were independently associated with risk for severe COVID-19. Conclusions The risk factors which predict higher overall mortality among patients with CLD and COVID-19 are ALD, decompensated cirrhosis and HCC. Hispanic ethnicity and decompensated cirrhosis are associated with severe COVID-19. Our results will enable risk stratification and personalization of the management of patients with CLD and COVID-19. url: https://doi.org/10.1016/j.cgh.2020.09.027 doi: 10.1016/j.cgh.2020.09.027 id: cord-266583-avhiqlgy author: Kim, Hae Jin title: Ultra-Low-Dose Chest CT in Patients with Neutropenic Fever and Hematologic Malignancy: Image Quality and Its Diagnostic Performance date: 2014-07-18 words: 4618.0 sentences: 678.0 pages: flesch: 59.0 cache: ./cache/cord-266583-avhiqlgy.txt txt: ./txt/cord-266583-avhiqlgy.txt summary: PURPOSE: The aim of this study was to evaluate the image quality of ultra-low-dose computed tomography (ULDCT) and its diagnostic performance in making a specific diagnosis of pneumonia in febrile neutropenic patients with hematological malignancy. Mean radiation expose dose of ULDCT was 0.60±0.15 mSv. Each observer regarded low-dose CT scans as unacceptable in only four (1.9%), one (0.5%), and three (1.5%) cases of ULDCTs. Sensitivity and area under the ROC curve in making a specific pneumonia diagnosis were 63.0%, 0.65 for reader 1; 63.0%, 0.61 for reader 2; and 65.0%, 0.62 for reader 3; respectively CONCLUSION: ULDCT, with a sub-mSv radiation dose and acceptable image quality, provides ready and reasonably acceptable diagnostic information for pulmonary infection in febrile neutropenic patients with hematologic malignancy abstract: PURPOSE: The aim of this study was to evaluate the image quality of ultra-low-dose computed tomography (ULDCT) and its diagnostic performance in making a specific diagnosis of pneumonia in febrile neutropenic patients with hematological malignancy. MATERIALS AND METHODS: ULDCT was performed prospectively in 207 febrile neutropenic patients with hematological malignancy. Three observers independently recorded the presence of lung parenchymal abnormality, and also indicated the cause of the lung parenchymal abnormality between infectious and noninfectious causes. If infectious pneumonia was considered the cause of lung abnormalities, they noted the two most appropriate diagnoses among four infectious conditions, including fungal, bacterial, viral, and Pneumocystis pneumonia. Sensitivity for correct diagnoses and receiver operating characteristic (ROC) curve analysis for evaluation of diagnostic accuracy were calculated. Interobserver agreements were determined using intraclass correlation coefficient. RESULTS: Of 207 patients, 139 (67%) had pneumonia, 12 had noninfectious lung disease, and 56 had no remarkable chest computed tomography (CT) (20 with extrathoracic fever focus and 36 with no specific disease). Mean radiation expose dose of ULDCT was 0.60±0.15 mSv. Each observer regarded low-dose CT scans as unacceptable in only four (1.9%), one (0.5%), and three (1.5%) cases of ULDCTs. Sensitivity and area under the ROC curve in making a specific pneumonia diagnosis were 63.0%, 0.65 for reader 1; 63.0%, 0.61 for reader 2; and 65.0%, 0.62 for reader 3; respectively CONCLUSION: ULDCT, with a sub-mSv radiation dose and acceptable image quality, provides ready and reasonably acceptable diagnostic information for pulmonary infection in febrile neutropenic patients with hematologic malignancy url: https://www.ncbi.nlm.nih.gov/pubmed/25308150/ doi: 10.4143/crt.2013.132 id: cord-353648-rl9dts7l author: Kim, Hyun Joo title: Guidelines for the control and prevention of coronavirus disease (COVID-19) transmission in surgical and anesthetic settings date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.4097/kja.20235 doi: 10.4097/kja.20235 id: cord-289311-0wgafqdz author: Kim, Jee-Eun title: Neurological Complications during Treatment of Middle East Respiratory Syndrome date: 2017-06-30 words: 3555.0 sentences: 209.0 pages: flesch: 44.0 cache: ./cache/cord-289311-0wgafqdz.txt txt: ./txt/cord-289311-0wgafqdz.txt summary: Since the first case of Middle East respiratory syndrome (MERS) was reported in Saudi Arabia in 2012, 1,826 laboratory-confirmed cases have been documented in 27 countries, and 35.5% of these patients have died from this novel virus. A triple antiviral treatment regimen comprising subcutaneous pegylated interferon alpha-2a (180 µg per week for 2 weeks), high-dose oral ribavirin [2,000 mg loading dose, followed by 1,200 mg every 8 h (q8h) for 4 days and then 600 mg q8h for 4-6 days], and oral lopinavir/ritonavir (400 mg/100 mg q12h for 10 days) was administered to all patients regardless of disease severity, which was in accordance with the interim recommendations generated during the early period of the Korean MERS epidemic. 10 GI: gastrointestinal, HFNC: high-flow nasal cannula oxygen therapy, IFN: type 1 interferon, IVIG: intravenous immunoglobulin, LR: lopinavir/ritonavir, MERS: Middle East respiratory syndrome, PSI: Pneumonia Severity Index, Rb: ribavirin, SAPS II: Simplified Acute Physiology Score II. abstract: BACKGROUND AND PURPOSE: Middle East respiratory syndrome (MERS) has a high mortality rate and pandemic potential. However, the neurological manifestations of MERS have rarely been reported since it first emerged in 2012. METHODS: We evaluated four patients with laboratory-confirmed MERS coronavirus (CoV) infections who showed neurological complications during MERS treatment. These 4 patients were from a cohort of 23 patients who were treated at a single designated hospital during the 2015 outbreak in the Republic of Korea. The clinical presentations, laboratory findings, and prognoses are described. RESULTS: Four of the 23 admitted MERS patients reported neurological symptoms during or after MERS-CoV treatment. The potential diagnoses in these four cases included Bickerstaff's encephalitis overlapping with Guillain-Barré syndrome, intensive-care-unit-acquired weakness, or other toxic or infectious neuropathies. Neurological complications did not appear concomitantly with respiratory symptoms, instead being delayed by 2–3 weeks. CONCLUSIONS: Neuromuscular complications are not rare during MERS treatment, and they may have previously been underdiagnosed. Understanding the neurological manifestations is important in an infectious disease such as MERS, because these symptoms are rarely evaluated thoroughly during treatment, and they may interfere with the prognosis or require treatment modification. url: https://www.ncbi.nlm.nih.gov/pubmed/28748673/ doi: 10.3988/jcn.2017.13.3.227 id: cord-350052-9431xqu1 author: Kim, Ji Heui title: Detection of respiratory viruses in adult patients with perennial allergic rhinitis date: 2013-09-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The symptoms of allergic rhinitis may be worsened by a viral respiratory infection. However, there are few data on the presence of respiratory virus in patients with allergic rhinitis. OBJECTIVE: To evaluate whether patients with allergic rhinitis have an increased frequency of respiratory virus detection in a prospective case–control study. METHODS: Fifty-eight adult patients diagnosed with perennial allergic rhinitis were evaluated from September 2011 through June 2012. A control group of 61 adult patients without allergy was included. Multiplex polymerase chain reaction was used to detect respiratory viruses in nasal lavage samples. RESULTS: Respiratory viruses were detected in 25 of 58 patients (43.1%) with perennial allergic rhinitis, but in only 15 of 61 control patients (24.6%). In virus-positive samples, multiple viruses were detected in 9 of 25 patients (36.0%) with perennial allergic rhinitis but in only 2 of 15 control patients (12.5%). Rhinovirus was the most common virus in patients without allergy and those with allergic rhinitis. There were significant differences in the detection rates of overall and multiple respiratory viruses and rhinovirus between the 2 groups (P < .05). However, in patients with allergic rhinitis, there was no statistically significant association between the detection of respiratory viruses and symptom scores. CONCLUSION: This study shows that there is a high prevalence of respiratory viruses, especially rhinovirus, in patients with allergic rhinitis. Subsequent studies are needed to determine the clinical significance of highly prevalent respiratory viruses in patients with allergic rhinitis. url: https://api.elsevier.com/content/article/pii/S1081120613006121 doi: 10.1016/j.anai.2013.08.024 id: cord-300044-vn4c6wh7 author: Kim, Ji Won title: From White Count to White Out() date: 2015-08-05 words: 2848.0 sentences: 182.0 pages: flesch: 43.0 cache: ./cache/cord-300044-vn4c6wh7.txt txt: ./txt/cord-300044-vn4c6wh7.txt summary: Rare causes, such as pneumonia from atypical agents from an undiagnosed immunodeficiency, congenital heart disease, methemoglobinemia, and pulmonary malformations, should be entertained as possible components of the differential diagnosis in the ED. In this child, the differential diagnosis narrows significantly to a pulmonary etiology in a patient who had infiltrates on chest radiograph and whose respiratory distress and hypoxia responded readily to supplemental oxygen, making the diagnosis of congenital heart disease unlikely. Viral bronchiolitis typically presents with upper respiratory symptoms followed by lower respiratory infection resulting in wheezing and rales in children younger than two years of age. 1 Pneumonia is another common cause of hypoxia and respiratory distress in children and can be the result of both bacterial and viral infections. 6, 7 PCP is one of the opportunistic infections with which patients with Hyper IgM syndrome may present. abstract: We present a 6-month-old boy with failure to thrive who was referred to the emergency department by his primary care doctor for leukocytosis and was found to be hypoxic with diffuse infiltrates on chest radiograph. Our patient was admitted and eventually diagnosed with Pneumocystis jirovecii pneumonia secondary to hyper immunoglobulin M syndrome. Even though P jirovecii pneumonia is an uncommon cause of hypoxia in infants, this case illustrates the need for pediatric emergency physicians to be cognizant of this rare but life threatening cause of hypoxia. url: https://doi.org/10.1016/j.cpem.2015.08.002 doi: 10.1016/j.cpem.2015.08.002 id: cord-286853-9gbel3pq author: Kim, Jiwon title: Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19 date: 2020-10-27 words: 2125.0 sentences: 108.0 pages: flesch: 35.0 cache: ./cache/cord-286853-9gbel3pq.txt txt: ./txt/cord-286853-9gbel3pq.txt summary: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a growing pandemic that confers augmented risk for right ventricular (RV) dysfunction and dilation; the prognostic utility of adverse RV remodeling in COVID-19 patients is uncertain. OBJECTIVES: The purpose of this study was to test whether adverse RV remodeling (dysfunction/dilation) predicts COVID-19 prognosis independent of clinical and biomarker risk stratification. Cardiac injury has also been reported to predict prognosis among COVID-19-infected patients, as evidenced by outcomes data that troponin elevation was present in 46% of nonsurvivors as opposed to 1% of survivors (5) and was associated with a >10-fold increased risk of mortality among hospitalized COVID-19 patients (6) . Related to this, it is important to note that whereas our results demonstrate adverse RV remodeling to strongly predict mortality in critically ill patients with COVID-19, available study data was insufficient to establish the mechanism for RV dilation or dysfunction. abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a growing pandemic that confers augmented risk for right ventricular (RV) dysfunction and dilation; the prognostic utility of adverse RV remodeling in COVID-19 patients is uncertain. OBJECTIVES: The purpose of this study was to test whether adverse RV remodeling (dysfunction/dilation) predicts COVID-19 prognosis independent of clinical and biomarker risk stratification. METHODS: Consecutive COVID-19 inpatients undergoing clinical transthoracic echocardiography at 3 New York City hospitals were studied; images were analyzed by a central core laboratory blinded to clinical and biomarker data. RESULTS: In total, 510 patients (age 64 ± 14 years, 66% men) were studied; RV dilation and dysfunction were present in 35% and 15%, respectively. RV dysfunction increased stepwise in relation to RV chamber size (p = 0.007). During inpatient follow-up (median 20 days), 77% of patients had a study-related endpoint (death 32%, discharge 45%). RV dysfunction (hazard ratio [HR]: 2.57; 95% confidence interval [CI]: 1.49 to 4.43; p = 0.001) and dilation (HR: 1.43; 95% CI: 1.05 to 1.96; p = 0.02) each independently conferred mortality risk. Patients without adverse RV remodeling were more likely to survive to hospital discharge (HR: 1.39; 95% CI: 1.01 to 1.90; p = 0.041). RV indices provided additional risk stratification beyond biomarker strata; risk for death was greatest among patients with adverse RV remodeling and positive biomarkers and was lesser among patients with isolated biomarker elevations (p ≤ 0.001). In multivariate analysis, adverse RV remodeling conferred a >2-fold increase in mortality risk, which remained significant (p < 0.01) when controlling for age and biomarker elevations; the predictive value of adverse RV remodeling was similar irrespective of whether analyses were performed using troponin, D-dimer, or ferritin. CONCLUSIONS: Adverse RV remodeling predicts mortality in COVID-19 independent of standard clinical and biomarker-based assessment. url: https://www.ncbi.nlm.nih.gov/pubmed/33092732/ doi: 10.1016/j.jacc.2020.08.066 id: cord-253129-v5lck9l7 author: Kim, Kyeong Tae title: Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial date: 2020-02-01 words: 8900.0 sentences: 540.0 pages: flesch: 54.0 cache: ./cache/cord-253129-v5lck9l7.txt txt: ./txt/cord-253129-v5lck9l7.txt summary: BACKGROUND: Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. The Clinical utilisation of respiratory elastance (CURE) trial is a two-arm, randomised controlled trial (RCT) investigating the performance of PEEP selected at an objective, model-based minimal respiratory system elastance in patients with ARDS. Secondary outcomes include length of time of MV, ventilator-free days (VFD) up to 28 days, ICU and hospital length of stay, AUC of oxygen saturation (SpO(2))/FiO(2) during MV, number of desaturation events (SpO(2) < 88%), changes in respiratory mechanics and chest x-ray index scores, rescue therapies (prone positioning, nitric oxide use, extracorporeal membrane oxygenation) and hospital and 90-day mortality. Following the study, a phase-2 randomised controlled trial (RCT) was designed to assess mechanical ventilation at minimal elastance PEEP in patients with ARDS versus standard practice of care in a single-centre hospital. abstract: BACKGROUND: Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. The Clinical utilisation of respiratory elastance (CURE) trial is a two-arm, randomised controlled trial (RCT) investigating the performance of PEEP selected at an objective, model-based minimal respiratory system elastance in patients with ARDS. METHODS AND DESIGN: The CURE RCT compares two groups of patients requiring invasive MV with a partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio ≤ 200; one criterion of the Berlin consensus definition of moderate (≤ 200) or severe (≤ 100) ARDS. All patients are ventilated using pressure controlled (bi-level) ventilation with tidal volume = 6–8 ml/kg. Patients randomised to the control group will have PEEP selected per standard practice (SPV). Patients randomised to the intervention will have PEEP selected based on a minimal elastance using a model-based computerised method. The CURE RCT is a single-centre trial in the intensive care unit (ICU) of Christchurch hospital, New Zealand, with a target sample size of 320 patients over a maximum of 3 years. The primary outcome is the area under the curve (AUC) ratio of arterial blood oxygenation to the fraction of inspired oxygen over time. Secondary outcomes include length of time of MV, ventilator-free days (VFD) up to 28 days, ICU and hospital length of stay, AUC of oxygen saturation (SpO(2))/FiO(2) during MV, number of desaturation events (SpO(2) < 88%), changes in respiratory mechanics and chest x-ray index scores, rescue therapies (prone positioning, nitric oxide use, extracorporeal membrane oxygenation) and hospital and 90-day mortality. DISCUSSION: The CURE RCT is the first trial comparing significant clinical outcomes in patients with ARDS in whom PEEP is selected at minimum elastance using an objective model-based method able to quantify and consider both inter-patient and intra-patient variability. CURE aims to demonstrate the hypothesized benefit of patient-specific PEEP and attest to the significance of real-time monitoring and decision-support for MV in the critical care environment. TRIAL REGISTRATION: Australian New Zealand Clinical Trial Registry, ACTRN12614001069640. Registered on 22 September 2014. (https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=366838&isReview=true) The CURE RCT clinical protocol and data usage has been granted by the New Zealand South Regional Ethics Committee (Reference number: 14/STH/132). url: https://www.ncbi.nlm.nih.gov/pubmed/32007099/ doi: 10.1186/s13063-019-4035-7 id: cord-336621-0w3rroir author: Kim, Kyoung Ok title: A first step toward understanding patient safety date: 2016-07-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patient safety has become an important policy agenda in healthcare systems since publication of the 1999 report entitled "To Err Is Human." The paradigm has changed from blaming the individual for the error to identifying the weakness in the system that led to the adverse events. Anesthesia is one of the first healthcare specialties to adopt techniques and lessons from the aviation industry. The widespread use of simulation programs and the application of human factors engineering to clinical practice are the influences of the aviation industry. Despite holding relatively advanced medical technology and comparable safety records, the Korean health industry has little understanding of the systems approach to patient safety. Because implementation of the existing system and program requires time, dedication, and financial support, the Korean healthcare industry is in urgent need of developing patient safety policies and putting them into practice to improve patient safety before it is too late. url: https://www.ncbi.nlm.nih.gov/pubmed/27703622/ doi: 10.4097/kjae.2016.69.5.429 id: cord-029615-x498xj3m author: Kim, Michelle Kang title: A Primer for Clinician Deployment to the Medicine Floors from an Epicenter of Covid-19 date: 2020-05-04 words: 2914.0 sentences: 133.0 pages: flesch: 44.0 cache: ./cache/cord-029615-x498xj3m.txt txt: ./txt/cord-029615-x498xj3m.txt summary: The first step in effective deployment was for the Department of Medicine (DOM) Chair to name the decision makers and establish a command structure with formalized roles and responsibilities.1 Anticipated responsibilities were divided and delegated based upon those individuals'' strengths and networks.2 DOM Vice Chairs were delegated specific responsibilities related to the build-out of the inpatient service (Table 1) , which required full-time commitment and temporary suspension of all non-Covid research and clinical activities. Additional DOM vice chairs coordinated personal protective equipment (PPE) needs with hospital administration, provided education regarding PPE use, onboarded outpatient physicians and facilitated their inpatient electronic medical record (EMR) access and training, and created teaching modules on treatment of the acutely ill Covid patient. In addition, volunteers and locum tenens providers were rapidly onboarded and integrated into teams and schedules.13 All remaining medicine divisions and other departments were asked to identify nurse practitioners (NPs), physician assistants (PAs), residents, and fellows eligible for deployment to the surge medical teams. abstract: Leaders at Mount Sinai Hospital in New York City created a task force to address staffing needs to care for hospitalized patients during the coronavirus surge. The group developed and acted on six overarching principles to address clinical, logistical, and personal needs of patients and staff. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371316/ doi: 10.1056/cat.20.0180 id: cord-325511-ot66dj3i author: Kim, Philip title: Managing Intrathecal Drug Delivery Devices in a Global Pandemic date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32358991/ doi: 10.1111/ner.13176 id: cord-321748-9a54ekac author: Kim, Sang Il title: Walk-Through Screening Center for COVID-19: an Accessible and Efficient Screening System in a Pandemic Situation date: 2020-04-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: With the ongoing novel coronavirus disease 2019 (COVID-19) pandemic, the number of individuals that need to be tested for COVID-19 has been rapidly increasing. A walk-through (WT) screening center using negative pressure booths that is inspired by the biosafety cabinet has been designed and implemented in Korea for easy screening of COVID-19 and for safe and efficient consultation for patients with fever or respiratory symptoms. Here, we present the overall concept, advantages, and limitations of the COVID-19 WT screening center. The WT center increases patient access to the screening clinics and adequately protects healthcare personnel while reducing the consumption of personal protective equipment. It can also increase the number of people tested by 9–10 fold. However, there is a risk of cross-infection at each stage of screening treatment, including the booths, and adverse reactions with disinfection of the booths. These limitations can be overcome using mobile technology and increasing the number of booths to reduce congestion inside the center, reducing booth volume for sufficient and rapid ventilation, and using an effective, harmless, and certified environmental disinfectant. A WT center can be implemented in other institutions and countries and modified depending on local needs to cope with the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32301300/ doi: 10.3346/jkms.2020.35.e154 id: cord-340766-aic570x8 author: Kim, Se Jin title: Outcomes of Early Administration of Cidofovir in Non-Immunocompromised Patients with Severe Adenovirus Pneumonia date: 2015-04-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The benefits of treatment with antiviral therapy for severe adenovirus (AdV) pneumonia are not well established. We described the clinical characteristics and treatment outcomes of early cidofovir treatment of severe AdV pneumonia in non-immunocompromised patients. We retrospectively reviewed the medical records of all patients diagnosed with severe AdV pneumonia between 2012 and 2014. A total of seven non-immunocompromised patients with severe AdV pneumonia were identified, and all isolates typed (n = 6) were human AdV-B55. All patients had progressive respiratory failure with lobar consolidation with or without patchy ground glass opacity. Three patients required vasopressors and mechanical ventilation. All patients had abnormal laboratory findings including: leukopenia, thrombocytopenia, or elevated liver enzymes. After admission, all patients received antiviral therapy with cidofovir, and the median time from admission to cidofovir administration was 48 h and median the time from onset of symptoms to cidofovir administration was 7.1 days. After cidofovir administration, complete symptomatic improvement occurred after a median of 12 days and radiographic resolution occurred after a median of 21 days. Consequently, all patients completely improved without complications. Our data suggest that early administration of cidofovir in the course of treatment for respiratory failure as a result of AdV pneumonia in non-immunocompromised patients could be a treatment strategy worth considering, especially in cases of HAdV-55 infection. url: https://www.ncbi.nlm.nih.gov/pubmed/25875735/ doi: 10.1371/journal.pone.0122642 id: cord-328895-p75b7jii author: Kim, Yeon-Yong title: Effects of patients’ motives in choosing a provider on determining the type of medical institution date: 2017-11-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Primary care is relatively weak in the Republic of Korea. As the referral system is not well established, patients can freely choose from among clinics, hospitals, and tertiary hospitals. This study was conducted to determine the factors influencing patients’ choice of providers. METHODS: A survey was conducted of 999 Korean adults aged 19–59 years. An exploratory factor analysis was performed on nine factors influencing their motives in choosing a medical provider. The factors derived from this analysis and the types of medical institutions were used as the independent and dependent variables, respectively, in logistic regression analysis. Adjustments were made for region, gender, age, educational level, income, type of insurance, and chronic diseases. RESULTS: The results showed that patients preferred clinics when considering the importance of accessibility, staff kindness, and patient-centeredness; they preferred hospitals when considering cleanliness; and tertiary hospitals when considering the reputation and structural factors. When considering structural factors, clinics and hospitals were less preferred; however tertiary hospitals were less preferred when considering accessibility, staff kindness, and patient-centeredness. CONCLUSION: It is necessary to provide more accessible and patient-centered services in order to strengthen the primary health care role of clinics. In addition, efforts are needed to improve the quality of health care of tertiary hospitals in order to meet patient expectations. url: https://doi.org/10.2147/ppa.s148530 doi: 10.2147/ppa.s148530 id: cord-006426-baf2d47y author: Kimura, Fumio title: Immunosuppression following surgical and traumatic injury date: 2010-08-26 words: 9852.0 sentences: 569.0 pages: flesch: 37.0 cache: ./cache/cord-006426-baf2d47y.txt txt: ./txt/cord-006426-baf2d47y.txt summary: Suppression of cell-mediated immunity may be caused by multifaceted cytokine/inhibitor profiles in the circulation and other compartments of the host, excessive activation and dysregulated recruitment of polymorphonuclear neutrophils, induction of alternatively activated or regulatory macrophages that have anti-inflammatory properties, a shift in the T-helper (Th)1/Th2 balance toward Th2, appearance of regulatory T cells, which are potent suppressors of the innate and adaptive immune system, and lymphocyte apoptosis in patients with sepsis. 13, 14 In response to major tissue injury and/or bacterial infection, endothelial and epithelial cells, as well as neutrophils, macrophages, and lymphocytes, produce powerful proinfl ammatory cytokines, especially tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6. abstract: Severe sepsis and organ failure are still the major causes of postoperative morbidity and mortality after major hepatobiliary pancreatic surgery. Despite recent progress in understanding the immune conditions of abdominal sepsis, the postoperative incidence of septic complications after major visceral surgery remains high. This review focuses on the clinical and immunological parameters that determine the risk of the development and lethal outcome of postoperative septic complication following major surgery and trauma. A review of the literature indicates that surgical and traumatic injury profoundly affects the innate and adaptive immune responses, and that a marked suppression in cell-mediated immunity following an excessive inflammatory response appears to be responsible for the increased susceptibility to subsequent sepsis. The innate and adaptive immune responses are initiated and modulated by pathogen-associated molecular-pattern molecules and by damage-associated molecular-pattern molecules through the pattern-recognition receptors. Suppression of cell-mediated immunity may be caused by multifaceted cytokine/inhibitor profiles in the circulation and other compartments of the host, excessive activation and dysregulated recruitment of polymorphonuclear neutrophils, induction of alternatively activated or regulatory macrophages that have anti-inflammatory properties, a shift in the T-helper (Th)1/Th2 balance toward Th2, appearance of regulatory T cells, which are potent suppressors of the innate and adaptive immune system, and lymphocyte apoptosis in patients with sepsis. Recent basic and clinical studies have elucidated the functional effects of surgical and traumatic injury on the immune system. The research studies of interest may in future aid in the selection of appropriate therapeutic protocols. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101797/ doi: 10.1007/s00595-010-4323-z id: cord-266469-n484zqq1 author: King, Michael J. title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system date: 2020-07-04 words: 4127.0 sentences: 209.0 pages: flesch: 44.0 cache: ./cache/cord-266469-n484zqq1.txt txt: ./txt/cord-266469-n484zqq1.txt summary: title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system Data is rapidly emerging given the novel nature of this devastating disease, with a paucity of published reports investigating abdominal presenting symptoms and subsequent CT imaging findings in COVID-19 patients. The purpose of our study is to describe the demographic, clinical, biological, and lung base CT findings in COVID-19 patients presenting with acute abdominal complaints, either in isolation or in combination with respiratory complaints. In this study, we described demographic, clinical, biological, and lung base CT findings in a population of COVID-19 patients who presented to our Health System with acute abdominal complaints, either in isolation or in combination with respiratory complaints. In conclusion, we report demographic, clinical, biological, and lung base CT findings in a group of patients presenting to our Health System with acute abdominal complaints who were found to have COVID-19. abstract: OBJECTIVE: To describe demographic, clinical, and lung base CT findings in COVID-19 patients presenting with abdominal complaints. METHODS: In this retrospective study, 76 COVID-19 patients who underwent abdominal CT for abdominal complaints from March 1 to April 15, 2020, in a large urban multihospital Health System were included. Those with positive abdominal CT findings (n = 14) were then excluded, with 62 patients undergoing final analysis (30M/32F; median age 63 years, interquartile range (IQR) 52–75 years, range 30–90 years). Demographic and clinical data were extracted. CT lung base assessment was performed by a cardiothoracic radiologist. Data were compared between discharged and hospitalised patients using Wilcoxon or Fisher’s exact tests. RESULTS: The majority of the population was non-elderly (56.4%, < 65 years) and most (81%) had underlying health conditions. Nineteen percent were discharged and 81% were hospitalised. The most frequent abdominal symptoms were pain (83.9%) and nausea/vomiting/anorexia (46.8%). Lung base CT findings included ground-glass opacities (95.2%) in a multifocal (95.2%) and peripheral (66.1%) distribution. Elevated laboratory values (when available) included C-reactive protein (CRP) (97.3%), D-dimer (79.4%), and ferritin (68.8% of males and 81.8% of females). Older age (p = 0.045), hypertension (p = 0.019), and lower haemoglobin in women (p = 0.042) were more frequent in hospitalised patients. There was no difference in lung base CT findings between discharged and hospitalised patients (p > 0.165). CONCLUSIONS: COVID-19 patients can present with abdominal symptoms, especially in non-elderly patients with underlying health conditions. Lung base findings on abdominal CT are consistent with published reports. Radiologists should be aware of atypical presentations of COVID-19. KEY POINTS: • COVID-19 infected patients can present with acute abdominal symptoms, especially in non-elderly patients with underlying health conditions, and may frequently require hospitalisation (81%). • There was no difference in lung base CT findings between patients who were discharged and those who were hospitalised. • Lung base CT findings included multifocal and peripheral ground-glass opacities, consistent with published reports. url: https://doi.org/10.1007/s00330-020-07040-z doi: 10.1007/s00330-020-07040-z id: cord-011255-9q2frk71 author: Kippnich, Maximilian title: Dual-room twin-CT scanner in multiple trauma care: first results after implementation in a level one trauma centre date: 2020-04-25 words: 3451.0 sentences: 196.0 pages: flesch: 57.0 cache: ./cache/cord-011255-9q2frk71.txt txt: ./txt/cord-011255-9q2frk71.txt summary: The time intervals from the arrival of a patient in the resuscitation room to the start of CT and of emergency surgery has been defined as the main quality indicator for the whole process of trauma resuscitation. For those patients, we collected the time to CT (tCT), the time to emergency surgery (tOR), the injury severity score (ISS) and outcome variables (mortality, ventilator-dependent days and length of intensive care unit (ICU) stay). A new and large-scale trauma resuscitation area with a dual-room sliding gantry CT scanner for simultaneous treatment or two multiple trauma patients by its was introduced (SOMATOM Definition Edge, Siemens Healthineers, Erlangen, Germany). Focused Fig. 1 Large-scale trauma resuscitation area with a dual-room sliding gantry CT scanner assessment with sonography for trauma (FAST) is performed only on haemodynamically unstable patients or if the ''leading group'' decides to do so. Whole-body multislice computed tomography (MSCT) improves trauma care in patients requiring surgery after multiple trauma abstract: PURPOSE: The trauma centre of the Wuerzburg University Hospital has integrated a pioneering dual-room twin-CT scanner in a multiple trauma pathway. For concurrent treatment of two trauma patients, two carbon CT examination and intervention tables are positioned head to head with one sliding CT-Gantry in the middle. The focus of this study is the process of trauma care with the time to CT (tCT) and the time to operation (tOR) as quality indicator. METHODS: All patients with suspected multiple trauma, who required emergency surgery and who were initially diagnosed by the CT trauma protocol between 05/2018 and 12/2018 were included. Data relating to time spans (tCT and tOR), severity of injury and outcome was obtained. RESULTS: 110 of the 589 screened trauma patients had surgery immediately after finishing primary assessment in the ER. The ISS was 17 (9–34) (median and interquartile range, IQR). tCT was 15 (11–19) minutes (median and IQR) and tOR was 96.5 (75–119) minutes (median and IQR). In the first 30 days, seven patients died (6.4%) including two within the first 24 h (2%). There were two ICU days (1–6) (median and IQR) and one (0–1) (median and IQR) ventilator day. CONCLUSION: The twin-CT technology is a fascinating tool to organize high-quality trauma care for two multiple trauma patients simultaneously. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223892/ doi: 10.1007/s00068-020-01374-5 id: cord-104180-f3hoz9bu author: Kirk-Bayley, Justin title: Recently published papers: inflammation, elucidation, manipulation? date: 2003-07-03 words: 1548.0 sentences: 84.0 pages: flesch: 42.0 cache: ./cache/cord-104180-f3hoz9bu.txt txt: ./txt/cord-104180-f3hoz9bu.txt summary: They looked at end-organ epithelial cell apoptosis in a rabbit model of ARDS and at the effects of plasma on epithelial cells from recipients of the injurious ventilatory strategy, and analyzed samples from a previous trial into lung protective ventilation [8] . Choosing the right ventilation strategy for ARDS patients has more benefits than just lung protection, and therapeutic targeting of these factors that induce end organ apoptosis may be the next step. Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC270703/ doi: nan id: cord-284910-vjcrhwqz author: Kirresh, Ali title: COVID-19 infection and high intracoronary thrombus burden date: 2020-07-30 words: 1773.0 sentences: 88.0 pages: flesch: 38.0 cache: ./cache/cord-284910-vjcrhwqz.txt txt: ./txt/cord-284910-vjcrhwqz.txt summary: Emerging evidence demonstrates a strong association with a pro-thrombotic state and we present the first patient admitted with COVID-19 and an inferior ST-segment elevation myocardial infarction (STEMI) with evidence of high intracoronary thrombus burden. We review the mechanism of the high thrombus burden, which may be driven by the significant cytokine storm, endothelial dysfunction, increase risk of coronary plaque rupture and hypercoagulability. We present the first patient admitted with inferior ST-segment elevation myocardial infarction (STEMI) with evidence of high intracoronary thrombus burden and provide a review of potential underlying mechanisms. There are emerging theories regarding the mechanism of increased thrombus burden seen in COVID-19, central to which seems to be a significant proinflammatory state (8). Plaque rupture results in an increase in tissue factor (TF), collagen and platelet activation causing increased fibrin production and a higher thrombus burden (16) . abstract: Abstract Coronavirus 2019 (COVID-19) is an acute respiratory disease that has rapidly spread around the world and been declared a global pandemic by the World Health Organization. Emerging evidence demonstrates a strong association with a pro-thrombotic state and we present the first patient admitted with COVID-19 and an inferior ST-segment elevation myocardial infarction (STEMI) with evidence of high intracoronary thrombus burden. We review the mechanism of the high thrombus burden, which may be driven by the significant cytokine storm, endothelial dysfunction, increase risk of coronary plaque rupture and hypercoagulability. url: https://www.sciencedirect.com/science/article/pii/S1553838920304590?v=s5 doi: 10.1016/j.carrev.2020.07.032 id: cord-343443-ljehete1 author: Kissling, Sébastien title: Collapsing glomerulopathy in a COVID-19 patient. date: 2020-04-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.kint.2020.04.006 doi: 10.1016/j.kint.2020.04.006 id: cord-022216-k4pi30sd author: Kliegman, Robert M. title: Neonatal necrotizing enterocolitis date: 2009-05-15 words: 6110.0 sentences: 329.0 pages: flesch: 32.0 cache: ./cache/cord-022216-k4pi30sd.txt txt: ./txt/cord-022216-k4pi30sd.txt summary: Neonatal necrotizing enterocolitis (NEC) is a disease of unknown origin that predominantly affects premature infants in level II, or more often level III, neonatal intensive care units during the infant''s convalescence from the common cardiopulmonary disorders associated with prematurity. 1, 7 Indeed, NEC is the most common cause of gastrointestinal perforation (followed by isolated idiopathic focal intestinal perforation) and acquired short bowel syndrome among patients in the neonatal intensive care unit. 1, 12 Although NEC is noted predominantly in premature neonates, approximately 10% of cases occur in nearly full-term or full-term infants whose preceding risk factors have included polycythemia, cyanotic heart disease or heart disease producing low cardiac output (before or after surgery), chronic diarrhea, endocrine disorders (hypothyroidism, panhypopituitarism, congenital adrenal hyperplasia) or a prior anatomic obstructive gastrointestinal malformation (volvulus or gastroschisis). 1, 12, 14 Alternatively, direct pharmacologic effects of an agent on systemic host defense (vitamin E), motility (morphine) or regional blood flow (indomethacin) may result in mucosal injury, increasing the risks for NEC in susceptible neonates. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155452/ doi: 10.1016/b978-0-7216-3924-6.50047-0 id: cord-320831-owfnttqr author: Klimek, Ludger title: Allergen immunotherapy in the current COVID-19 pandemic: A position paper of AeDA, ARIA, EAACI, DGAKI and GPA: Position paper of the German ARIA Group(A) in cooperation with the Austrian ARIA Group(B), the Swiss ARIA Group(C), German Society for Applied Allergology (AEDA)(D), German Society for Allergology and Clinical Immunology (DGAKI)(E), Society for Pediatric Allergology (GPA)(F) in cooperation with AG Clinical Immunology, Allergology and Environmental Medicine of the DGHNO-KHC(G) and the European Academy of Allergy and Clinical Immunology (EAACI)(H) date: 2020-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: No abstract available. url: https://doi.org/10.5414/alx02147e doi: 10.5414/alx02147e id: cord-345381-9cckppk2 author: Klimek, Ludger title: Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)(A), Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)(B), Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)(C), Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)(D), Luxemburgische Gesellschaft für Allergologie und Immunologie (LGAI)(E), Österreichische Gesellschaft für Pneumologie (ÖGP)(F) in co-operation with the German, Austrian, and Swiss ARIA groups(G), and the European Academy of Allergy and Clinical Immunology (EAACI)(H) date: 2020-09-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Since the beginning of the COVID-19 pandemic, the treatment of patients with allergic and atopy-associated diseases has faced major challenges. Recommendations for “social distancing” and the fear of patients becoming infected during a visit to a medical facility have led to a drastic decrease in personal doctor-patient contacts. This affects both acute care and treatment of the chronically ill. The immune response after SARS-CoV-2 infection is so far only insufficiently understood and could be altered in a favorable or unfavorable way by therapy with monoclonal antibodies. There is currently no evidence for an increased risk of a severe COVID-19 course in allergic patients. Many patients are under ongoing therapy with biologicals that inhibit type 2 immune responses via various mechanisms. There is uncertainty about possible immunological interactions and potential risks of these biologicals in the case of an infection with SARS-CoV-2. Materials and methods: A selective literature search was carried out in PubMed, Livivo, and the internet to cover the past 10 years (May 2010 – April 2020). Additionally, the current German-language publications were analyzed. Based on these data, the present position paper provides recommendations for the biological treatment of patients with allergic and atopy-associated diseases during the COVID-19 pandemic. Results: In order to maintain in-office consultation services, a safe treatment environment must be created that is adapted to the pandemic situation. To date, there is a lack of reliable study data on the care for patients with complex respiratory, atopic, and allergic diseases in times of an imminent infection risk from SARS-CoV-2. Type-2-dominant immune reactions, as they are frequently seen in allergic patients, could influence various phases of COVID-19, e.g., by slowing down the immune reactions. Theoretically, this could have an unfavorable effect in the early phase of a SARS-Cov-2 infection, but also a positive effect during a cytokine storm in the later phase of severe courses. However, since there is currently no evidence for this, all data from patients treated with a biological directed against type 2 immune reactions who develop COVID-19 should be collected in registries, and their disease courses documented in order to be able to provide experience-based instructions in the future. Conclusion: The use of biologicals for the treatment of bronchial asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and spontaneous urticaria should be continued as usual in patients without suspected infection or proven SARS-CoV-2 infection. If available, it is recommended to prefer a formulation for self-application and to offer telemedical monitoring. Treatment should aim at the best possible control of difficult-to-control allergic and atopic diseases using adequate rescue and add-on therapy and should avoid the need for systemic glucocorticosteroids. If SARS-CoV-2 infection is proven or reasonably suspected, the therapy should be determined by weighing the benefits and risks individually for the patient in question, and the patient should be involved in the decision-making. It should be kept in mind that the potential effects of biologicals on the immune response in COVID-19 are currently not known. Telemedical offers are particularly desirable for the acute consultation needs of suitable patients. url: https://doi.org/10.5414/alx02166e doi: 10.5414/alx02166e id: cord-355533-5kgdg2nb author: Kline, Jonathan D title: Sentinel Case of COVID-19 at Fort Stewart, GA in a National Guard Soldier Participating in Annual Training: A Case Report date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: For healthcare providers, specifically military and federal public health personnel, prompt and accurate diagnosis and isolation of SARS-CoV-2 novel coronavirus patients provide a two-fold benefit: (1) directing appropriate treatment to the infected patient as early as possible in the progression of the disease to increase survival rates and minimize the devastating sequelae following recovery and remission of symptoms; (2) provide critical information requirements that enable commanders and public health officials to best synchronize policy, regulations, and troop movement restrictions while best allocating scarce resources in the delicate balance of risk mitigation versus mission readiness. Simple personal protective measures and robust testing and quarantine procedures, instituted and enforced aggressively by senior leaders, physicians, and healthcare professionals at all levels are an essential aspect of the battle against the COVID-19 pandemic that will determine the success or failure of the overall effort. As consideration, the authors respectfully submit this vignette of the first confirmed positive COVID-19 case presenting to the Emergency Department at Winn Army Community Hospital, Fort Stewart, Georgia. url: https://www.ncbi.nlm.nih.gov/pubmed/32567656/ doi: 10.1093/milmed/usaa144 id: cord-336810-77wq9laa author: Klocperk, Adam title: Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19 date: 2020-09-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This study aimed to assess the key laboratory features displayed by coronavirus disease 2019 (COVID-19) inpatients that are associated with mild, moderate, severe, and fatal courses of the disease, and through a longitudinal follow-up, to understand the dynamics of the COVID-19 pathophysiology. All severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients admitted to the University Hospital in Motol between March and June 2020 were included in this study. A severe course of COVID-19 was associated with an elevation of proinflammatory markers; an efflux of immature granulocytes into peripheral blood; the activation of CD8 T cells, which infiltrated the lungs; transient liver disease. In particular, the elevation of serum gamma-glutamyl transferase (GGT) and histological signs of cholestasis were highly specific for patients with a severe form of the disease. In contrast, patients with a fatal course of COVID-19 failed to upregulate markers of inflammation, showed discoordination of the immune response, and progressed toward acute kidney failure. COVID-19 is a disease with a multi-organ affinity that is characterized by the activation of innate and cellular adaptive immunity. Biliary lesions with an elevation of GGT and the organ infiltration of interleukin 6 (IL-6)-producing cells are the defining characteristics for patients with the fulminant disease. url: https://doi.org/10.3390/jcm9093000 doi: 10.3390/jcm9093000 id: cord-007580-qwh8ei60 author: Knopf, Harry L.S. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 words: 5104.0 sentences: 320.0 pages: flesch: 53.0 cache: ./cache/cord-007580-qwh8ei60.txt txt: ./txt/cord-007580-qwh8ei60.txt summary: We had three major goals: to determine the rate of viral recovery from cases of nonepidemic acute or subacute follicular conjunc tivitis; to compare the accuracy of clinical diagnoses with that achieved by culture or serologic studies, or both; and to explore the possible role of serum antibody in the forma tion and maintenance of corneal subepithelial infiltrates. 4 VIRAL KERATOCONJUNCTIVITIS 663 antibody titers to vaccinia, herpes, coxsackievirus A-9, A-16, and A-21, and four strains of acute hemorrhagic conjunctivitis virus were similarly assayed by serum neutraliza tion tests in human diploid fibroblast tissue culture. Table 2* shows the difference between the number of positive isolates ob tained by culturing before or after the eighth * All of the data for the epidemic keratoconjunc tivitis group were published elsewhere, except for the corneal quantitative material in clinical studies.'' day of illness. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119397/ doi: 10.1016/0002-9394(75)90398-0 id: cord-308466-f0iu6sje author: Ko, Fanny W. title: Acute exacerbation of COPD date: 2016-03-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The literature of acute exacerbation of chronic obstructive pulmonary disease (COPD) is fast expanding. This review focuses on several aspects of acute exacerbation of COPD (AECOPD) including epidemiology, diagnosis and management. COPD poses a major health and economic burden in the Asia‐Pacific region, as it does worldwide. Triggering factors of AECOPD include infectious (bacteria and viruses) and environmental (air pollution and meteorological effect) factors. Disruption in the dynamic balance between the ‘pathogens’ (viral and bacterial) and the normal bacterial communities that constitute the lung microbiome likely contributes to the risk of exacerbations. The diagnostic approach to AECOPD varies based on the clinical setting and severity of the exacerbation. After history and examination, a number of investigations may be useful, including oximetry, sputum culture, chest X‐ray and blood tests for inflammatory markers. Arterial blood gases should be considered in severe exacerbations, to characterize respiratory failure. Depending on the severity, the acute management of AECOPD involves use of bronchodilators, steroids, antibiotics, oxygen and noninvasive ventilation. Hospitalization may be required, for severe exacerbations. Nonpharmacological interventions including disease‐specific self‐management, pulmonary rehabilitation, early medical follow‐up, home visits by respiratory health workers, integrated programmes and telehealth‐assisted hospital at home have been studied during hospitalization and shortly after discharge in patients who have had a recent AECOPD. Pharmacological approaches to reducing risk of future exacerbations include long‐acting bronchodilators, inhaled steroids, mucolytics, vaccinations and long‐term macrolides. Further studies are needed to assess the cost‐effectiveness of these interventions in preventing COPD exacerbations. url: https://doi.org/10.1111/resp.12780 doi: 10.1111/resp.12780 id: cord-290006-63sa00ju author: Ko, Jane P. title: Approach to Peribronchovascular Disease on CT date: 2018-12-20 words: 6389.0 sentences: 453.0 pages: flesch: 37.0 cache: ./cache/cord-290006-63sa00ju.txt txt: ./txt/cord-290006-63sa00ju.txt summary: 14 Other lymphoproliferative disorders affecting the lung and pleura also include nodular lymphoid hyperplasia and Castleman''s disease, which lack monoclonal proliferation, in addition to primary effusion lymphoma that affects pleural, pericardial, or peritoneal spaces in immunocompromised individuals such as with acquired immune deficiency syndrome (AIDS). 43 Subsequently, a number of etiologies known to cause a reversed-halo sign and include infection such as zygomycosis, invasive apergillosis, tuberculosis, histoplasmosis, cryptococcosis, Pneumocystis jirovecii pneumonia, paracoccidioidomycosis; infarct from pulmonary embolism; eosinophilic processes; post-lung ablation and stereotactic body radiation therapy changes; lung adenocarcinomas; granulomatosis with polyangiitis; lymphoproliferative disorders; and sarcoidosis. Aspergillus infection affects immunocompromised patients, such as those on steroids, leukemia, and after bone marrow and organ transplantation, often in the form of angioinvasive aspergillosis (ANG), although airway invasive aspergillus (AIA) is another manifestation that is associated with peribronchial opacities. Viral infections affect the lung interstitum and present on CT with centrilobular nodules, ground-glass opacity, consolidation, and bronchial wall thickening (Fig. 7) . abstract: Diseases that are predominantly peribronchovascular in distribution on computed tomography by definition involve the bronchi, adjacent vasculature, and associated lymphatics involving the central or axial lung interstitium. An understanding of diseases that can present with focal peribronchovascular findings is useful for establishing diagnoses and guiding patient management. This review will cover clinical and imaging features that may assist in differentiating amongst the various causes of primarily peribronchovascular disease. url: https://api.elsevier.com/content/article/pii/S0887217118301306 doi: 10.1053/j.sult.2018.12.002 id: cord-317966-ut6tzc8s author: Kocak, Burak title: A Case Report of Oligosymptomatic Kidney Transplant Patients with COVID-19: Do They Pose a Risk to Other Recipients? date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.transproceed.2020.05.028 doi: 10.1016/j.transproceed.2020.05.028 id: cord-259801-xuvcrvo2 author: Koch, Christian A. title: The Various Faces of Hyperthyroidism date: 2020-06-05 words: 2063.0 sentences: 109.0 pages: flesch: 37.0 cache: ./cache/cord-259801-xuvcrvo2.txt txt: ./txt/cord-259801-xuvcrvo2.txt summary: It starts out with an important article by Hoermann and colleagues underscoring the biochemically heterogeneous expression of thyroid hormone activities in subclinical/overt hyperthyroidism and exogenous thyrotoxicosis (1) . In their study of 461 patients composed of untreated thyroid autonomy, Graves'' disease, and levothyroxine TSH suppressive therapy after thyroidectomy for thyroid carcinoma, they demonstrate that deiodinase activity is markedly reduced in patients with exogenous thyrotoxicosis compared to patients with endogenous hyperthyroidism because of a lack of TSH stimulation, inhibition by levothyroxine, and the absence of a functioning thyroid gland. Cipolla and colleagues share their experience performing total thyroidectomy on 594 patients with Graves'' disease between age 32 y and 56 y underscoring that it is a safe and effective treatment in experienced hands (15) . Zhou and colleagues underscore the important role of neural monitoring during thyroid surgery for Graves'' disease in their retrospective series including 55 thyroidectomies and 82 procedures with intermittent intraoperative neuromonitoring (IONM) and 72 procedures with continuous IONM (19) . abstract: nan url: https://api.elsevier.com/content/article/pii/S221462372030082X doi: 10.1016/j.jcte.2020.100229 id: cord-266294-ua22udlc author: Koch, Oliver title: 29 Antiviral drugs date: 2010-12-31 words: 10777.0 sentences: 526.0 pages: flesch: 47.0 cache: ./cache/cord-266294-ua22udlc.txt txt: ./txt/cord-266294-ua22udlc.txt summary: Metabolism The hemochromatosis gene polymorphism HFE 187C> G and possibly mitochondrial haplogroup J gave relative protection against lipoatrophy during antiretroviral drug therapy in a trial in which 96 patients were randomized to didanosine þ stavudine or zidovudine þ lamivudine, combined with efavirenz and/ or nelfinavir in AIDS Clinical Trials Group (ACTG) 384 sub-study A5005s (20 C ). Gastrointestinal In a retrospective obser vational study of highly active antiretroviral therapy (HAART), 27 of 50 patients who took indinavir in combination with zidovudine and lamivudine developed nausea and were significantly more likely to stop taking the treatment than those who were taking zidovudine þ lamivudine þ tenofovir (24 c ). abstract: Publisher Summary This chapter discusses the adverse effects of antiviral drugs used against cytomegalovirus, herpesviruses, hepatitis viruses, against HIV, and against influenza viruses. The cidofovir, drug active against cytomegalovirus, has been associated with bronchiolitis obliterans. Aciclovir and valaciclovir has been reported with renal insufficiency. Adefovir , a drug active against hepatitis viruses, is associated with the fall in creatinine clearance in patients with lamivudine-resistant HBe antigen (HBeAg)negative disease. Drugs active against HIV are comprehensively reviewed as in combination, nucleoside analogue reverse transcriptase inhibitors, nucleoside analogue reverse transcriptase inhibitors, and protease inhibitors. In a randomized controlled trial of indinavir, saquinavir and lopinavir in combination with low-dose ritonavir in 656 patients, median total cholesterol increased by 0.5 mmol/l in the patients with the highest minimum drug plasma concentrations. In patients with AIDS-associated AIDS dementia complex taking optimal stable background antiretroviral therapy including either abacavir or placebo, there was significantly more nausea in those who took abacavir. url: https://www.sciencedirect.com/science/article/pii/S0378608010320290 doi: 10.1016/s0378-6080(10)32029-0 id: cord-277539-xt2nt11e author: Kochhar, Anuraj Singh title: Dentistry during and after COVID-19 Pandemic: Pediatric Considerations date: 2020 words: 4502.0 sentences: 296.0 pages: flesch: 50.0 cache: ./cache/cord-277539-xt2nt11e.txt txt: ./txt/cord-277539-xt2nt11e.txt summary: Despite the avalanche of information that has exploded in relation to this rapidly spreading disease, there is a lack of consolidated information to guide dentists regarding clinical management including precautions to take materials to use and postprocedure care, during and after the COVID-19 pandemic. This review aims to provide a comprehensive summary from the available literature on COVID-19, its insinuation in dentistry, recommendations that have been published, and the actual in-practice implications, so a plan can be formulated and adapted to the circumstances of each dental practice during the pandemic and the times to follow. The purpose of this review is to provide a comprehensive summary from the available literature on COVID-19, its insinuation in dentistry, recommendations that have been published, and the actual in-practice implications, so a plan of measures can be formulated and adapted according to the circumstances of each dental practice during the pandemic and the times to follow. abstract: This article is a rumination on the outbreak of the dreaded coronavirus disease-2019 (COVID-19) pandemic which has engulfed both the developed and the developing countries, thereby causing widespread global public health concerns and threats to human lives. Although countries have made varied efforts, the pestilence is escalating due to the high infectivity. It is highly likely that dental professionals in upcoming days will come across COVID-19 patients and SARS-CoV-2 carriers, and hence must ensure a tactful handling of such patients to prevent its nosocomial spread. Despite the avalanche of information that has exploded in relation to this rapidly spreading disease, there is a lack of consolidated information to guide dentists regarding clinical management including precautions to take materials to use and postprocedure care, during and after the COVID-19 pandemic. Available sources of information have been analyzed, while relying on peer-reviewed reports followed by information available from the most respected authoritative sources, such as WHO, Centers for Disease Control and Prevention (CDC), and ADA. This review aims to provide a comprehensive summary from the available literature on COVID-19, its insinuation in dentistry, recommendations that have been published, and the actual in-practice implications, so a plan can be formulated and adapted to the circumstances of each dental practice during the pandemic and the times to follow. HOW TO CITE THIS ARTICLE: Kochhar AS, Bhasin R, Kochhar GK, et al. Dentistry during and after COVID-19 Pandemic: Pediatric Considerations. Int J Clin Pediatr Dent 2020;13(4):399–406. url: https://www.ncbi.nlm.nih.gov/pubmed/33149414/ doi: 10.5005/jp-journals-10005-1782 id: cord-324843-r43u7sld author: Kockuzu, Esra title: Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey date: 2019-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To analyze the course of seasonal viral infections of respiratory tract in patients hospitalized in pediatric intensive care units (PICU) of 16 centers in Turkey. MATERIALS AND METHODS: It is a retrospective, observational, and multicenter study conducted in 16 tertiary PICUs in Turkey includes a total of 302 children with viral cause in the nasal swab which required PICU admission with no interventions. RESULTS: Median age of patients was 12 months. Respiratory syncytial virus (RSV) was more common in patients over one year of age whereas influenza, human Bocavirus in patients above a year of age was more common (p <0.05). Clinical presentations influencing mortality were neurologic symptoms, tachycardia, hypoxia, hypotension, elevated lactate, and acidosis. The critical pH value related with mortality was ≤7.10, and critical PCO(2) ≥60 mm Hg. CONCLUSION: Our findings demonstrate that patients with neurological symptoms, tachycardia, hypoxia, hypotension, acidosis, impaired liver, and renal function at the time of admission exhibit more severe mortal progressions. Presence of acidosis and multiorgan failure was found to be predictor for mortality. Knowledge of clinical presentation and age-related variations among seasonal viruses may give a clue about severe course and prognosis. By presenting the analyzed data of 302 PICU admissions, current study reveals severity of viral respiratory tract infections and release tips for handling them. HOW TO CITE THIS ARTICLE: Kockuzu E, Bayrakcı B, Kesici S, Cıtak A, Karapınar K, Emeksiz S, et al. Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs During the Winter Season in Turkey. Indian J Crit Care Med 2019;23(6):263–269. url: https://doi.org/10.5005/jp-journals-10071-23177 doi: 10.5005/jp-journals-10071-23177 id: cord-004263-m1ujhhsc author: Koekkoek, W. A. C. title: The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study date: 2020-02-03 words: 3155.0 sentences: 178.0 pages: flesch: 44.0 cache: ./cache/cord-004263-m1ujhhsc.txt txt: ./txt/cord-004263-m1ujhhsc.txt summary: title: The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study METHODS: We studied a cohort of adult critically ill patients requiring invasive mechanical ventilation and treatment with continuous infusion of cisatracurium for at least 12 h. CONCLUSIONS: Our data suggest that continuous infusion of cisatracurium in mechanically ventilated ICU patients is associated with a significant reduction in EE, although the magnitude of the effect is small. Our data suggest that continuous infusion of cisatracurium in mechanically ventilated ICU patients is associated with a significant reduction in EE as estimated by the VCO 2 method, although the magnitude of the effect is small. Validation of carbon dioxide production (VCO2) as a tool to calculate resting energy expenditure (REE) in mechanically ventilated critically ill patients: a retrospective observational study abstract: BACKGROUND: Both overfeeding and underfeeding of intensive care unit (ICU) patients are associated with worse outcomes. A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomena. Several factors that influence EE have been studied previously. However, the effect of neuromuscular blocking agents on EE, which conceptually would lower EE, has not been extensively investigated. METHODS: We studied a cohort of adult critically ill patients requiring invasive mechanical ventilation and treatment with continuous infusion of cisatracurium for at least 12 h. The study aimed to quantify the effect of cisatracurium infusion on EE (primary endpoint). EE was estimated based on ventilator-derived VCO(2) (EE in kcal/day = VCO(2) × 8.19). A subgroup analysis of septic and non-septic patients was performed. Furthermore, the effects of body temperature and sepsis on EE were evaluated. A secondary endpoint was hypercaloric feeding (> 110% of EE) after cisatracurium infusion. RESULTS: In total, 122 patients were included. Mean EE before cisatracurium infusion was 1974 kcal/day and 1888 kcal/day after cisatracurium infusion. Multivariable analysis showed a significantly lower EE after cisatracurium infusion (MD − 132.0 kcal (95% CI − 212.0 to − 52.0; p = 0.001) in all patients. This difference was statistically significant in both sepsis and non-sepsis patients (p = 0.036 and p = 0.011). Non-sepsis patients had lower EE than sepsis patients (MD − 120.6 kcal; 95% CI − 200.5 to − 40.8, p = 0.003). Body temperature and EE were positively correlated (Spearman’s rho = 0.486, p < 0.001). Hypercaloric feeding was observed in 7 patients. CONCLUSIONS: Our data suggest that continuous infusion of cisatracurium in mechanically ventilated ICU patients is associated with a significant reduction in EE, although the magnitude of the effect is small. Sepsis and higher body temperature are associated with increased EE. Cisatracurium infusion is associated with overfeeding in only a minority of patients and therefore, in most patients, no reductions in caloric prescription are necessary. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998072/ doi: 10.1186/s13054-020-2744-7 id: cord-256849-8w2avwo2 author: Koenig, Kristi L. title: Identify-Isolate-Inform: A Tool for Initial Detection and Management of Measles Patients in the Emergency Department date: 2015-03-18 words: 2864.0 sentences: 172.0 pages: flesch: 52.0 cache: ./cache/cord-256849-8w2avwo2.txt txt: ./txt/cord-256849-8w2avwo2.txt summary: title: Identify-Isolate-Inform: A Tool for Initial Detection and Management of Measles Patients in the Emergency Department The "Identify-Isolate-Inform" tool will assist emergency physicians to be better prepared to detect and manage measles patients presenting to the emergency department. Emergency physicians must rapidly inform the local public health department and hospital infection control personnel of suspected measles cases. Following a brief review of measles, this paper describes the novel 3I tool, initially developed for Ebola virus disease, 4 as adapted for use in the initial detection and management of measles patients in the emergency department (ED). During a measles outbreak, after donning appropriate respiratory protection, emergency physicians (EP) should carefully assess the oropharynx in patients presenting with non-specific viral syndromes and assess for the presence of Koplik spots. 12 Conversely, patients with signs and symptoms of measles (prodrome of fever, cough/coryza/conjunctivitis, Koplik spots followed by rash), should be immediately masked and isolated using airborne precautions. abstract: Measles (rubeola) is a highly contagious airborne disease that was declared eliminated in the U.S. in the year 2000. Only sporadic U.S. cases and minor outbreaks occurred until the larger outbreak beginning in 2014 that has become a public health emergency. The “Identify-Isolate-Inform” tool will assist emergency physicians to be better prepared to detect and manage measles patients presenting to the emergency department. Measles typically presents with a prodrome of high fever, and cough/coryza/conjunctivitis, sometimes accompanied by the pathognomonic Koplik spots. Two to four days later, an erythematous maculopapular rash begins on the face and spreads down the body. Suspect patients must be immediately isolated with airborne precautions while awaiting laboratory confirmation of disease. Emergency physicians must rapidly inform the local public health department and hospital infection control personnel of suspected measles cases. url: https://doi.org/10.5811/westjem.2015.3.25678 doi: 10.5811/westjem.2015.3.25678 id: cord-297414-zq16s9ud author: Koh, Adrian H. C. title: What COVID-19 has taught us: lessons from around the globe date: 2020-06-13 words: 1777.0 sentences: 95.0 pages: flesch: 51.0 cache: ./cache/cord-297414-zq16s9ud.txt txt: ./txt/cord-297414-zq16s9ud.txt summary: This was integrated with the NHI PharmaCloud System, which allowed thorough checks on the travel and medical history of preregistered patients for all outpatient clinic visits, day This article is part of a topical collection on Perspectives on COVID-19 surgery, scheduled examinations, or hospital admissions in advance [8] . Measures in the clinic include plastic barrier shields mounted to slit lamps and machines; all staff are asked to wear cap, eye goggles, protective clothing, surgical mask, and glove during clinic; video calls to check the patients with fever and red eye but not yet diagnosed with COVID at the emergency department. The fact is, telemedicine has been proposed and discussed for several decades before the COVID pandemic, but the current situation where many countries have imposed lockdowns and restrictions to travel to clinics and hospitals has greatly accelerated its use and implementation [10] . Virtual visits in ophthalmology: timely advice for implementation during the COVID-19 public health crisis abstract: nan url: https://doi.org/10.1007/s00417-020-04791-9 doi: 10.1007/s00417-020-04791-9 id: cord-258727-mhg56j20 author: Kolar, Dusan title: Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic date: 2020-08-08 words: 428.0 sentences: 23.0 pages: flesch: 49.0 cache: ./cache/cord-258727-mhg56j20.txt txt: ./txt/cord-258727-mhg56j20.txt summary: It is also worth noting that most of the patients with severe and refractory mood disorders and comorbid anxiety disorders followed in the mood disorders specialized clinic remained stable and well served remotely via telemedicine instead of in-person visits over the last 3-4 months of COVID-19 pandemic. Patients are well supported by their family members who stay at home during the COVID-19 lockdown and this experience of togetherness obviously was beneficial for patients with mood disorders. Finally, many people are working from home during the COVID-19 pandemic. Working from home is beneficial for some patients with mood and anxiety disorders as they are not exposed to social stress at their work place. Psychiatric emergency department volume during Covid-19 pandemic COVID-19 pandemic: impact on psychiatric care in the United States Psychiatrist experience of remote consultations by telephone in an outpatient psychiatric department during the COVID-19 pandemic abstract: nan url: https://doi.org/10.1007/s00406-020-01182-3 doi: 10.1007/s00406-020-01182-3 id: cord-025990-nj4ah2yz author: Konca, Capan title: Susceptibility Patterns of Multidrug-Resistant Acinetobacter baumannii date: 2020-06-04 words: 3224.0 sentences: 188.0 pages: flesch: 47.0 cache: ./cache/cord-025990-nj4ah2yz.txt txt: ./txt/cord-025990-nj4ah2yz.txt summary: OBJECTIVES: To investigate the antimicrobial resistance patterns of multidrug-resistant Acinetobacter baumannii (MDRAB) in patients in pediatric intensive care units (PICU) in order to determine a guide for the empirical antibiotic treatment of MDRAB. Thus, in order to determine a guide for the empirical antibiotic treatment of MDRAB, the authors investigated the antimicrobial resistance patterns of MDRAB in patients in pediatric intensive care units (PICUs). In 2016, the isolates were found to have a resistance rate of above 90% against all antibiotics except for colistin and trimethoprim/sulfamethoxazole (Table 3 ). In a worrying study of MDRAB antibiotic susceptibility, it was reported that the colistin resistance rate increased to 35.7% in Iran [19] . A 5-year surveillance study on antimicrobial resistance of Acinetobacter baumannii clinical ısolates from a tertiary Greek hospital Antimicrobial susceptibility patterns of an emerging multidrug resistant nosocomial pathogen: Acinetobacter baumannii abstract: OBJECTIVES: To investigate the antimicrobial resistance patterns of multidrug-resistant Acinetobacter baumannii (MDRAB) in patients in pediatric intensive care units (PICU) in order to determine a guide for the empirical antibiotic treatment of MDRAB. METHODS: The authors retrospectively evaluated the medical records of patients with MDRAB infections in the PICU during a follow-up period, between January 2015 and January 2017. The identification of A. baumannii was performed using a BD Phoenix 100 Automated Microbiology System. A BD Phoenix NMIC/ID-400 commercial kit was used to test antibiotic susceptibility. All data was entered into Microsoft Excel, and the data was analyzed using SPSS version 23.0. RESULTS: The mean age of the patients was 8.1 ± 6.2 y. In all, 46 isolates were obtained from 33 patients. The most effective antimicrobial agents were colistin, trimethoprim/sulfamethoxazole, and tigecycline. Nevertheless, with the exception of colistin, no antibiotic was associated with a susceptibility rate of >45% for the isolates. Low sensitivities in 2015 to tigecycline, aminoglycosides, levofloxacin, and carbapenems had been lost in 2016. CONCLUSIONS: Many drugs that were previously effective against MDRAB, have lost their effectiveness. Currently, there is no effective drug to fight MDRAB, apart from colistin. Thus, it is clear that new drugs and treatment protocols should be developed urgently. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271137/ doi: 10.1007/s12098-020-03346-4 id: cord-308212-l8flyso7 author: Kong, Ha Eun title: Applying the ethical principles of resource allocation to drugs in limited supply during a public health crisis date: 2020-04-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.jaad.2020.04.078 doi: 10.1016/j.jaad.2020.04.078 id: cord-352577-h3652seb author: Kopić, Jasminka title: Expanding the Use of Noninvasive Ventilation During an Epidemic date: 2014-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Noninvasive ventilation (NIV) is a proved and effective therapeutic option for some patients with respiratory failure. During an epidemic, NIV can free up respirators and other intensive care unit equipment for patients with respiratory insufficiency whose survival depends exclusively on invasive ventilation. Some guidelines have indicated that NIV is potentially hazardous and should not be recommended for use during epidemics, given the perceived potential risk of transmission from aerosolized pathogen dispersion to other patients or medical staff. Conversely, some reports of previous epidemics describe NIV as a very efficient and safe modality of respiratory support, if strict infection control measures are implemented. We discuss NIV use during epidemics and indicate the need for prospective randomized clinical studies on the efficacy of NIV in epidemic conditions to provide important information to the current body of literature. Meanwhile, the use of NIV under strict infection control guidelines should be incorporated into epidemic preparedness planning. (Disaster Med Public Health Preparedness. 2014;8:1-5) url: https://doi.org/10.1017/dmp.2014.71 doi: 10.1017/dmp.2014.71 id: cord-277486-12uah5qi author: Kopp, Kristen title: Interdisciplinary Model for Scheduling Post-discharge Cardiopulmonary Care of Patients Following Severe and Critical SARS-CoV-2 (Coronavirus) Infection date: 2020-08-14 words: 3178.0 sentences: 146.0 pages: flesch: 32.0 cache: ./cache/cord-277486-12uah5qi.txt txt: ./txt/cord-277486-12uah5qi.txt summary: As Covid-19 can severely implicate the respiratory and cardiovascular systems, potential pulmonary, and/or cardiovascular sequelae may be anticipated in patients following severe and critical SARS-CoV-2 infection meriting coordinated post-discharge management to identify residual effects and to mitigate potential worsening of pre-existing conditions. The WHO report Interim Guidance: Clinical Management of Covid 19, released 27 May 2020 however anticipates potential sequelae in patients with severe and critical SARS-CoV-2 infection following treatment with mechanical ventilation, sedation, and/or prolonged bed rest based on evidence from general critical care populations. A coordinated post-discharge care concept for patients surviving Covid-19 is therefore warranted to identify any cardiopulmonary sequelae and to mitigate possible worsening of preexisting disease following severe and critical SARS-Cov-2 infection. Short, intermediate and long-term effects following severe and critical SARS-CoV-2 infection are unknown, and significant sequelae may be expected, especially in patient populations experiencing ARDS, sepsis, and/or multiple organ dysfunction, as well as patients with exacerbation or progression of preexisting pulmonary or cardiovascular disease. abstract: nan url: https://doi.org/10.3389/fcvm.2020.00157 doi: 10.3389/fcvm.2020.00157 id: cord-310891-yfouizjb author: Korada, Sai Krishna C. title: Management of COVID-19 in a Durable Left Ventricular Assist Device Recipient: A Continuity of Care Perspective date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 is impacting the cardiovascular community both here in the United States and globally. The rapidly emerging cardiac complications have heightened implications for those with underlying cardiovascular disease. We describe an early case of COVID-19 in a left ventricular assist device recipient in the United States. We discuss our clinical management during the initial admission, outpatient management, and a unique complication of this disease over a 40-day disease course. url: https://api.elsevier.com/content/article/pii/S0147956320303575 doi: 10.1016/j.hrtlng.2020.08.012 id: cord-309238-7lbt0f03 author: Koratala, Abhilash title: Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19: The Tri-POCUS Approach date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As the coronavirus disease 2019 (COVID-19) continues to spread across the globe, the knowledge of its epidemiology, clinical features, and management is rapidly evolving. Nevertheless, the data on optimal fluid management strategies for those who develop critical illness remain sparse. Adding to the challenge, the fluid volume status of these patients has been found to be dynamic. Some present with several days of malaise, gastrointestinal symptoms, and consequent hypovolemia requiring aggressive fluid resuscitation, while a subset develop acute respiratory distress syndrome with renal dysfunction and lingering congestion necessitating restrictive fluid management. Accurate objective assessment of volume status allows physicians to tailor the fluid management goals throughout this wide spectrum of critical illness. Conventional point-of-care ultrasonography (POCUS) enables the reliable assessment of fluid status and reducing the staff exposure. However, due to specific characteristics of COVID-19 (e.g., rapidly expanding lung lesions), a single imaging method such as lung POCUS will have significant limitations. Herein, we suggest a Tri-POCUS approach that represents concurrent bedside assessment of the lungs, heart, and the venous system. This combinational approach is likely to overcome the limitations of the individual methods and provide a more precise evaluation of the volume status in critically ill patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32460302/ doi: 10.1159/000508544 id: cord-337896-mct29erg author: Kornbluth, Asher title: Management of Inflammatory Bowel Disease and COVID-19 in New York City 2020: The Epicenter of IBD in the First Epicenter of the Global Pandemic date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/ibd/izaa212 doi: 10.1093/ibd/izaa212 id: cord-275266-e6omvo5x author: Kort, Nanne P title: Resuming hip and knee arthroplasty after COVID-19: ethical implications for well-being, safety and the economy date: 2020-07-07 words: 5308.0 sentences: 259.0 pages: flesch: 47.0 cache: ./cache/cord-275266-e6omvo5x.txt txt: ./txt/cord-275266-e6omvo5x.txt summary: 7, 8 These economic factors will influence the decision to re-start elective total joint Resuming hip and knee arthroplasty after COVID-19: ethical implications for well-being, safety and the economy arthroplasty during the COVID-19 pandemic. This specific, informed consent (IC) for elective surgery in times of COVID-19 requires further discussion with the patient about higher risk of virus transmission including from healthcare workers, the long incubation period (up to 14 days), the variable nature of the disease from mild to fatal, and discussions regarding ceilings of care and the potential need for ventilation. In this challenging time, when reinstating elective surgery in a risky scenario with limited resources, surgeons have the responsibility to follow a shared decision-making process with the patient that includes an understanding of the legal aspects of complications, and COVID-19 specific, informed consent. abstract: Reinstating elective hip and knee arthroplasty services presents significant challenges. We need to be honest about the scale of the obstacles ahead and realise that the health challenges and economic consequences of the COVID-19 pandemic are potentially devastating. We must also prepare to make difficult ethical decisions about restarting elective hip and knee arthroplasty. These decisions should be based on the existing evidence-base, reliable data, the recommendations of experts, and regional circumstances. url: https://www.ncbi.nlm.nih.gov/pubmed/32635761/ doi: 10.1177/1120700020941232 id: cord-103214-3lz33pj3 author: Kortuem, S. O. title: The Role of the Emergency Department in Protecting the Hospital as a Critical Infrastructure in the Corona Pandemic Strategies and Experiences of a Rural Sole Acute-Care Clinic date: 2020-09-09 words: 4293.0 sentences: 263.0 pages: flesch: 50.0 cache: ./cache/cord-103214-3lz33pj3.txt txt: ./txt/cord-103214-3lz33pj3.txt summary: An essential strategic element was a very short-term restructuring of the Emergency Department with the objectives of reducing the number of cases within the clinic, detecting COVID-19 cases as sensitively as possible and separating the patient pathways at an early stage. After establishing a pre-triage with structured algorithms, all confirmed COVID-19 cases were identified before entering the clinic and assigned to an appropriate treatment pathway. . https://doi.org/10.1101/2020.09.07.20185819 doi: medRxiv preprint As of March 27, 2020, a specially developed algorithm for case detection was established, which, in addition to broader range of clinical criteria, focuses on the regionally observable epidemiological events in risk facilities, e. 7%) of the patients, neither direct contact with confirmed COVID-19 cases nor a stay in high-risk areas or facilities could be recorded at the time of pre-triage ( Figure 6 ). At this point, the Emergency Department has the key function of identifying those patients who need treatment with the hospital resources for medical reasons and referring other cases to the outpatient sector. abstract: Background. The Klinikum Hochrhein is responsible as a regional sole provider for the acute and emergency medical treatment of more than 170.000 people. Against the background of the pandemic spread of SARS-CoV-2 with expected high patient inflows and at the same time endangering one's own infrastructure due to intraclinical transmissions, the hospital management defined the maintenance of one's functionality as a priority protection objective in the pandemic. An essential strategic element was a very short-term restructuring of the Emergency Department with the objectives of reducing the number of cases within the clinic, detecting COVID-19 cases as sensitively as possible and separating the patient pathways at an early stage. Methods. The present work is a retrospective analysis of the processes and structures established in the Emergency Department between 27 March 2020 and 20 May 2020. In addition, a retrospective descriptive evaluation of the epidemiological and clinical data of the patients is carried out at the time of first contact during the period mentioned above. Results. After establishing a pre-triage with structured algorithms, all confirmed COVID-19 cases were identified before entering the clinic and assigned to an appropriate treatment pathway. Unprotected entry into hospital structures or nosocomial infections were not observed, although almost 35% of patients with confirmed infection were admitted due to other symptom complexes or injuries. 201 inpatient patients were initially isolated without COVID-19 being confirmed. The number of cases in the Emergency Department was 39% lower than the previous year's period, thus avoiding crowding. Discussion. The reduction in the number of cases was strategically intended and is primarily the result of a restrictive indication of in-clinical treatment but supported by a decline in emergency consultations that can be noticed anyway. The proportion of false positive triage results is probably dependent on epidemiological activity and was accepted for safety reasons as sufficient resources were available for isolation. Conclusion. Short-term organizational, spatial and procedural restructuring of the ZNA has enabled the clinic to achieve its goal of managing the pandemic. The algorithms we developed are particularly well suited to guarantee the desired level of safety in the case of a high pre-test probability. url: http://medrxiv.org/cgi/content/short/2020.09.07.20185819v1?rss=1 doi: 10.1101/2020.09.07.20185819 id: cord-265022-p5cab562 author: Kotfis, Katarzyna title: COVID-19: ICU delirium management during SARS-CoV-2 pandemic date: 2020-04-28 words: 5426.0 sentences: 256.0 pages: flesch: 34.0 cache: ./cache/cord-265022-p5cab562.txt txt: ./txt/cord-265022-p5cab562.txt summary: Indeed, patients with COVID-19 are at accelerated risk for delirium due to at least seven factors including (1) direct central nervous system (CNS) invasion, (2) induction of CNS inflammatory mediators, (3) secondary effect of other organ system failure, (4) effect of sedative strategies, (5) prolonged mechanical ventilation time, (6) immobilization, and (7) other needed but unfortunate environmental factors including social isolation and quarantine without family. Given early insights into the pathobiology of the virus, as well as the emerging interventions utilized to treat the critically ill patients, delirium prevention and management will prove exceedingly challenging, especially in the intensive care unit (ICU). Many hospitalized patients with COVID-19 will develop delirium, and given early insights into the pathobiology of this virus indicating invasion into the brain stem, as well as the emerging interventions utilized to treat these critically ill patients, delirium prevention and management may prove exceedingly challenging, especially in the intensive care unit (ICU). abstract: The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19), emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020. Delirium, a dangerous untoward prognostic development, serves as a barometer of systemic injury in critical illness. The early reports of 25% encephalopathy from China are likely a gross underestimation, which we know occurs whenever delirium is not monitored with a valid tool. Indeed, patients with COVID-19 are at accelerated risk for delirium due to at least seven factors including (1) direct central nervous system (CNS) invasion, (2) induction of CNS inflammatory mediators, (3) secondary effect of other organ system failure, (4) effect of sedative strategies, (5) prolonged mechanical ventilation time, (6) immobilization, and (7) other needed but unfortunate environmental factors including social isolation and quarantine without family. Given early insights into the pathobiology of the virus, as well as the emerging interventions utilized to treat the critically ill patients, delirium prevention and management will prove exceedingly challenging, especially in the intensive care unit (ICU). The main focus during the COVID-19 pandemic lies within organizational issues, i.e., lack of ventilators, shortage of personal protection equipment, resource allocation, prioritization of limited mechanical ventilation options, and end-of-life care. However, the standard of care for ICU patients, including delirium management, must remain the highest quality possible with an eye towards long-term survival and minimization of issues related to post-intensive care syndrome (PICS). This article discusses how ICU professionals (e.g., physicians, nurses, physiotherapists, pharmacologists) can use our knowledge and resources to limit the burden of delirium on patients by reducing modifiable risk factors despite the imposed heavy workload and difficult clinical challenges posed by the pandemic. url: https://doi.org/10.1186/s13054-020-02882-x doi: 10.1186/s13054-020-02882-x id: cord-335198-qp964238 author: Kotsimbos, T. title: Pandemic Treatments on Trial: The bigger picture date: 2020-08-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The tension between immediately using any potentially useful novel therapy in COVID19 and trialling all novel therapies as rigorously as possible is addressed from a bigger picture perspective. url: https://doi.org/10.1183/13993003.02281-2020 doi: 10.1183/13993003.02281-2020 id: cord-305838-i0ck2oo0 author: Kouri, Andrew title: CHEST Reviews: Addressing reduced laboratory-based pulmonary function testing during a pandemic date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract To reduce the spread of SARS-CoV-2, many pulmonary function testing (PFT) laboratories have been closed or have significantly reduced their testing capacity. As these mitigation strategies may be necessary for the next 6-18 months to prevent recurrent peaks in disease prevalence, fewer objective measurements of lung function will alter the diagnosis and care of patients with chronic respiratory diseases. PFTs, which include spirometry, lung volumes, and diffusion capacity measurement, are essential to the diagnosis and management of patients with asthma, COPD, and other chronic lung conditions. Both traditional and innovative alternatives to conventional testing must now be explored. These may include peak expiratory flow devices, electronic portable spirometers, portable exhaled nitric oxide measurement, airwave oscillometry devices, as well as novel digital health tools such as smartphone microphone spirometers, and mobile health technologies along integration of machine learning approaches. The adoption of some novel approaches may not merely replace but could improve existing management strategies and alter common diagnostic paradigms. With these options come important technical, privacy, ethical, financial, and medicolegal barriers that must be addressed. However, the COVID-19 pandemic also presents a unique opportunity to augment conventional testing by including innovative and emerging approaches to measuring lung function remotely in patients with respiratory disease. The benefits of such an approach have the potential to enhance respiratory care and empower patient self-management well beyond the current global pandemic. url: https://api.elsevier.com/content/article/pii/S0012369220318675 doi: 10.1016/j.chest.2020.06.065 id: cord-268347-xz6fptol author: Kow, Chia Siang title: Pharmacotherapeutic considerations for systemic rheumatic diseases amid the COVID-19 pandemic: more questions than answers date: 2020-08-16 words: 2665.0 sentences: 132.0 pages: flesch: 33.0 cache: ./cache/cord-268347-xz6fptol.txt txt: ./txt/cord-268347-xz6fptol.txt summary: It is not known for certain if there is an association between any pharmacological agent used for rheumatologic treatment, including biological and non-biological disease-modifying antirheumatic drugs (DMARDs), and an increased risk of COVID-19 acquisition or adverse outcomes from COVID-19, although these agents have been associated with an overall higher risk of infections. To illustrate, the aforementioned prospective case series [3] that included 86 patients from New York with confirmed or presumptive COVID-19 with concurrent immunemediated inflammatory disease reported no increased odds of COVID-19 hospitalization among those who were receiving biological agents or Janus kinase (JAK) inhibitors at baseline [adjusted odds ratio (OR) 0.85; 95% CI 0.71-1.02]. There are proven benefits for initiation or continuation of any pharmacological agents for the management of systemic rheumatic diseases, including treatment with conventional DMARDs and other immunosuppressive agents (e.g. hydroxychloroquine/chloroquine, sulfasalazine, methotrexate, leflunomide, tacrolimus, ciclosporin, mycophenolate mofetil and azathioprine), as well as biological DMARDs, such as abatacept, tocilizumab and JAK inhibitors (e.g. tofacitinib, baricitinib and upadacitinib). abstract: Thus far, associations between the presence of systemic rheumatic disease and an increased risk of novel coronavirus disease 2019 (COVID-19) acquisition or a worse prognosis from COVID-19 have not been conclusive. It is not known for certain if there is an association between any pharmacological agent used for rheumatologic treatment, including biological and non-biological disease-modifying antirheumatic drugs (DMARDs), and an increased risk of COVID-19 acquisition or adverse outcomes from COVID-19, although these agents have been associated with an overall higher risk of infections. The pharmacological management of patients with a rheumatic disease without COVID-19 should currently follow usual treatment approaches. Individualized approaches to adjusting DMARD regimens in patients with documented COVID-19 seems prudent, with specific attention paid to the severity of the infection. Patients receiving antimalarials (hydroxychloroquine/chloroquine) may continue treatment with these agents. Treatment with sulfasalazine, methotrexate, leflunomide, immunosuppressants and biological agents other than interluekin-6 receptor inhibitors and JAK inhibitors should be stopped or withheld. It should be reasonable to resume DMARD treatment when patients are no longer symptomatic and at least 2 weeks after documentation of COVID-19, although the decision should be individualized, preferably based on infection severity. url: https://doi.org/10.1007/s40267-020-00767-1 doi: 10.1007/s40267-020-00767-1 id: cord-326807-dii4u9gj author: Kow, Chia Siang title: Use of low-molecular-weight heparin in COVID-19 patients date: 2020-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2213333X20303401 doi: 10.1016/j.jvsv.2020.06.006 id: cord-003832-q1422ydi author: Koyama, Kansuke title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors date: 2019-08-19 words: 4659.0 sentences: 242.0 pages: flesch: 40.0 cache: ./cache/cord-003832-q1422ydi.txt txt: ./txt/cord-003832-q1422ydi.txt summary: title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors This study aimed to investigate the biomarker profiles of coagulopathy and alveolar epithelial injury in two subtypes of ARDS: patients with direct common risk factors (dARDS) and those with idiopathic or immune-related diseases (iARDS), which are classified as "ARDS without common risk factors" based on the Berlin definition. Although no risk factors or causes are identified in this subgroup of ARDS, recent studies have shown that many patients with idiopathic interstitial pneumonia have clinical features that suggest an underlying immune process, indicating that the pathobiology of idiopathic and immunerelated diseases may partially overlap [9, 10] . The aim of this study was to examine the profiles of the plasma biomarkers that reflect coagulopathy and alveolar epithelial injury in patients with idiopathic/immune-related ARDS (iARDS) and in those with common direct risk factors (dARDS). abstract: BACKGROUND: Altered coagulation and alveolar injury are the hallmarks of acute respiratory distress syndrome (ARDS). However, whether the biomarkers that reflect pathophysiology differ depending on the etiology of ARDS has not been examined. This study aimed to investigate the biomarker profiles of coagulopathy and alveolar epithelial injury in two subtypes of ARDS: patients with direct common risk factors (dARDS) and those with idiopathic or immune-related diseases (iARDS), which are classified as “ARDS without common risk factors” based on the Berlin definition. METHODS: This retrospective, observational study included adult patients who were admitted to the intensive care unit (ICU) at a university hospital with a diagnosis of ARDS with no indirect risk factors. Plasma biomarkers (thrombin–antithrombin complex [TAT], plasminogen activator inhibitor [PAI]-1, protein C [PC] activity, procalcitonin [PCT], surfactant protein [SP]-D, and KL-6) were routinely measured during the first 5 days of the patient’s ICU stay. RESULTS: Among 138 eligible patients with ARDS, 51 were excluded based on the exclusion criteria (n = 41) or other causes of ARDS (n = 10). Of the remaining 87 patients, 56 were identified as having dARDS and 31 as having iARDS. Among the iARDS patients, TAT (marker of thrombin generation) and PAI-1 (marker of inhibited fibrinolysis) were increased, and PC activity was above normal. In contrast, PC activity was significantly decreased, and TAT or PAI-1 was present at much higher levels in dARDS compared with iARDS patients. Significant differences were also observed in PCT, SP-D, and KL-6 between patients with dARDS and iARDS. The receiver operating characteristic (ROC) analysis showed that areas under the ROC curve for PC activity, PAI-1, PCT, SP-D, and KL-6 were similarly high for distinguishing between dARDS and iARDS (PC 0.86, P = 0.33; PAI-1 0.89, P = 0.95; PCT 0.89, P = 0.66; and SP-D 0.88, P = 0.16 vs. KL-6 0.90, respectively). CONCLUSIONS: Coagulopathy and alveolar epithelial injury were observed in both patients with dARDS and with iARDS. However, their biomarker profiles were significantly different between the two groups. The different patterns of PAI-1, PC activity, SP-D, and KL-6 may help in differentiating between these ARDS subtypes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13054-019-2559-6) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699073/ doi: 10.1186/s13054-019-2559-6 id: cord-009322-7l7slziv author: Kraetsch, Hans-Georg title: Verlauf und prognostische Parameter bei Still-Syndrom des Erwachsenen: Eigene Erfahrungen und Literaturübersicht date: 1997 words: 2073.0 sentences: 269.0 pages: flesch: 57.0 cache: ./cache/cord-009322-7l7slziv.txt txt: ./txt/cord-009322-7l7slziv.txt summary: □ PATIENTS AND METHODS: Ten patients with adult onset of Still''s disease (AOSD) were examined one to nine years after the established diagnosis. 1 971 beschfieb Bywaters 14 erwachsene Patienten mit Symptomen ~ihnlich denen einer juvenilen chronischen Polyarthritis, die frª als ,,Still''s disease" bezeichnet wurde [3] . Rey Words: AOSD 9 Adult onset of Still''s disease 9 Prognostic critefia 9 Course of disease 9 Outcome 9 Review of the literature 9 Case reports Med. Klin Betroffen sind vor allem der Stamm und die proximalen Extremiditen (Abbildung 2, Patient Nr. 8), gelegentlich aber auch das Gesicht [18] . Eine schwere hepatische Beteili~mg trat bei unserem sp~iter verstorbenen Patienten ira P,.ahmen eines hffmophagozytischen Syndroms auf[28], auch dies schon als seltene und lebensbedrohliche Komplikation des AOSD bekannt. Eine Verschmfflerung des Gelenkspaltes in Karpometakarpaloder Interkarpalgelenken mit sp~iterer kn6cherner Ankylosierung gilt als eine ftir das AOSD charakteristische radiologische Verffnderung [1] , die in dieser Forro bei unseren Patienten nicht zu beobachten war. abstract: □ PATIENTS AND METHODS: Ten patients with adult onset of Still’s disease (AOSD) were examined one to nine years after the established diagnosis. Clinical symptoms, laboratory parameters and the outcome of the cases are presented and compared to international literature and to Yamagushi’s in 1992 proposed diagnostic criteria. Nine patients were reexamined in our out-patient clinic. The chart of one additional patient, who died 10 month after the initial symptoms was also available for data analysis. Retrospectively, it was investigated whether any parameters were predictive for a chronic or severe form of the disease. □ RESULTS: One patient died 10 month after the diagnosis was established due to a secondary haemophagozytic syndrome. One patient developed a chronic form of the disease, whereas 2 patients had a chronic-remitting form. Six patients presented a self-limiting, shorter than 12 month lasting course of AOSD with a restitutio ad integrum. All patients fulfilled the diagnostic criteria of Yamagushi et al. Three of 10 patients developed a chronic form of AOSD, compared to up to 70% of the patients reported by others. The patient who died was significantly older (46 years) than the average age (24,9 years) of all patients. Interestingly, he did not present Still’s rash or lymphadenopathy, but rather developed a secondary hemophagocytic syndrome with an excessive hyperferritinaemia. □ CONCLUSION: Predicting parameters for a chronic course of the disease could not be found. Each patient’s diagnosis retrospectively could be confirmed using the Yamagushi’s diagnostic criteria. Thus, these criteria appear helpful in the difficult diagnostic process of this disease. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146029/ doi: 10.1007/bf03044666 id: cord-314349-rhm1ii3d author: Kraft, Miquel title: Incidence, features, outcome and impact on health system of de-novo abdominal surgical diseases in patients admitted with COVID-19 date: 2020-08-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective to assess the epidemiology and features of de novo surgical diseases in patients admitted with COVID-19, and their impact on patients and healthcare system. Summary Background Data Gastrointestinal involvement has been described in COVID-19; however, no clear figures of incidence, epidemiology and economic impact exist for de-novo surgical diseases in hospitalized patients Methods This is a prospective study including all patients admitted with confirmed SARS-CoV-2 rT-PCR, between 1 March and 15 May 2020 at two Tertiary Hospitals. Patients with known surgical disease at admission were excluded. Sub-analyses were performed with a consecutive group of COVID-19 patients admitted during the study period, who did not require surgical consultation. Results Ten out of 3089 COVID-19 positive patients (0.32%) required surgical consultation. Among those admitted in intensive care unit (ICU) incidence was 1.9%. Mortality was 40% in patients requiring immediate surgery and 20% in those suitable for conservative management. The overall median length of stay(LOS) of patients admitted to ICU was longer in those requiring surgical consultation compared with those who did not (51.5 vs 25 days,p=0.0042). Patients requiring surgical consultation and treatment for de-novo surgical disease had longer median ICU-LOS (31.5 vs 12 days, p=0.0004). A median of two post-surgical complications were registered for each patient undergoing surgery. Complication-associated costs were as high as 38,962 USD per patient. Conclusions Incidence of de-novo surgical diseases is low in COVID-19, but it is associated with significant morbidity and mortality. Future studies should elucidate the mechanism underlying the condition and identify strategies to prevent the need for surgery. url: https://www.ncbi.nlm.nih.gov/pubmed/32972853/ doi: 10.1016/j.surge.2020.08.006 id: cord-340799-1awmtj52 author: Krajewska, Joanna title: Review of practical recommendations for otolaryngologists and head and neck surgeons during the COVID-19 pandemic: Recommendations for otolaryngologists during the COVID-19 pandemic date: 2020-06-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Otolaryngologists are at very high risk of COVID-19 infection while performing examination or surgery. Strict guidelines for these specialists have not already been provided, while currently available recommendations could presumably change in course of COVID-19 pandemic as the new data increases. OBJECTIVES: This study aimed to synthesize evidence concerning otolaryngology during COVID‐19 pandemic. It presents a review of currently existing guidelines and recommendations concerning otolaryngological procedures and surgeries during COVID-19 pandemic, and provides a collective summary of all crucial information for otolaryngologists. It summarizes data concerning COVID-19 transmission, diagnosis, and clinical presentation highlighting the information significant for otolaryngologists. METHODS: The Medline and Web of Science databases were searched without time limit using terms ‘‘COVID-19”, “SARS-CoV-2” in conjunction with “head and neck surgery”, “otorhinolaryngological manifestations”. RESULTS: Patients in stable condition should be consulted using telemedicine options. Only emergency consultations and procedures should be performed during COVID-19 pandemic. Mucosa-involving otolaryngologic procedures are considered high risk procedures and should be performed using enhanced PPE (N95 respirator and full face shield or powered air-purifying respirator, disposable gloves, surgical cap, gown, shoe covers). Urgent surgeries for which there is not enough time for SARS-CoV-2 screening are also considered high risk procedures. These operations should be performed in a negative pressure operating room with high-efficiency particulate air filtration. Less urgent cases should be tested for COVID-19 twice, 48 hours preoperatively in 24 hours’ interval. CONCLUSIONS: This review serves as a collection of current recommendations for otolaryngologists for how to deal with their patients during COVID-19 pandemic. url: https://doi.org/10.1016/j.anl.2020.05.022 doi: 10.1016/j.anl.2020.05.022 id: cord-312199-jy3izkou author: Kraus, Kent R. title: Is There Benefit in Keeping Early Discharge Patients Overnight After Total Joint Arthroplasty? date: 2020-07-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: In recent years, cost containment relative to patent safety and quality of care for total joint arthroplasty (TJA) has been a key focus for the Centers for Medicare and Medicaid Services (CMS) spawning significant research and programmatic change, including a move toward early discharge and outpatient TJA. TJA outpatients receive few, if any, medical interventions prior to discharge, but the type and quantity of medical interventions provided for TJA patients who stay overnight in the hospital is unknown. This study quantified the nature, frequency, and outcome of interventions occurring overnight after primary TJA. METHODS: 1,725 consecutive primary unilateral TJAs performed between 2012 and 2017 by a single surgeon in a rapid-discharge program, managed by a perioperative internal medicine specialist, were reviewed. Medical records were examined for diagnostic tests, treatments, and procedures performed, results of interventions, and all-cause readmissions. Recorded interventions included any that varied from the preoperative treatment plan, were beyond standard-of-care, and could not be completed at home. RESULTS: 759 patients were discharged on postoperative day one. 84% (641/759) received no medical interventions during their overnight hospital stay. Twelve (1.6%) received diagnostic tests, 90 (11.9%) received treatments, and 29 (3.8%) received procedures. 92% (11/12) of diagnostic tests were negative, 66% of 100 treatments in 90 patients were intravenous fluids for oliguria or hypotension, and all procedures were in/out catheterizations for urinary retention. 90-day all cause readmission rates were similar in patients who received (2.5%) and did not receive (3.3%) a clinical intervention. CONCLUSION: The majority of patients received no overnight interventions, suggesting unnecessary costly hospitalization. The most common issues addressed were oliguria, urinary retention, and hypotension. Protocols to prevent these conditions would facilitate outpatient TJA, improve patient safety, and reduce costs. url: https://api.elsevier.com/content/article/pii/S0883540320307786 doi: 10.1016/j.arth.2020.07.021 id: cord-319930-ymqnb54a author: Kremer, Stéphane title: Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study date: 2020-06-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Brain MRI parenchymal signal abnormalities have been in association with SARS-CoV-2. PURPOSE: Describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe COVID-19 infection. METHODS: This was a retrospective study of patients evaluated from March 23th, 2020 to April 27th, 2020 at 16 hospitals. Inclusion criteria were: (i) positive nasopharyngeal or lower respiratory tract reverse transcriptase-polymerase chain reaction assays; (ii) severe COVID infection defined as requirement for hospitalization and oxygen therapy; (iii) neurologic manifestations; (iv) abnormal brain MRI. Exclusion criteria were patients with missing or non-contributory data regarding brain MRI or a brain MRI showing ischemic infarcts, cerebral venous thrombosis, or chronic lesions unrelated to the current event. Categorical data were compared using Fisher exact test. Quantitative data were compared using Student’s t-test or Wilcoxon test. A p-value lower than 0.05 was considered significant. RESULTS: Thirty men (81%) and 7 women (19%) met inclusion criteria, with a mean age of 61+/- 12 years (range: 8-78). The most common neurologic manifestations were alteration of consciousness (27/37, 73%), pathological wakefulness when the sedation was stopped (15/37, 41%), confusion (12/37, 32%), and agitation (7/37, 19%). The most frequent MRI findings were: signal abnormalities located in the medial temporal lobe in 16/37 (43%, 95% CI 27-59%) patients, non-confluent multifocal white matter hyperintense lesions on FLAIR and diffusion sequences, with variable enhancement, with associated hemorrhagic lesions in 11/37 patients (30%, 95% CI 15-45%), and extensive and isolated white matter microhemorrhages in 9/37 patients (24%, 95% CI 10-38%). A majority of patients (20/37, 54%) had intracerebral hemorrhagic lesions with a more severe clinical presentation: higher admission rate in intensive care units, 20/20 patients, 100% versus 12/17 patients, 71%, p=0.01; development of the acute respiratory distress syndrome in 20/20 patients, 100% versus 11/17 patients, 65%, p=0.005. Only one patient was positive for SARS-CoV-2 RNA in the cerebrospinal fluid. CONCLUSION: Patients with severe COVID-19 and without ischemic infarcts had a wide range of neurologic manifestations that were be associated with abnormal brain MRIs. Eight distinctive neuroradiological patterns were described. url: https://www.ncbi.nlm.nih.gov/pubmed/32544034/ doi: 10.1148/radiol.2020202222 id: cord-355031-l0tj7kp2 author: Krenitsky, Nicole M. title: Primed for a Pandemic: Implementation of Telehealth Outpatient Monitoring for Women with Mild COVID-19 date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Close observation and rapid escalation of care is essential for obstetric patients with COVID-19. The pandemic forced widespread conversion of in-person to virtual care delivery and telehealth was primed to enable outpatient surveillance of infected patients. We describe the experience and lessons learned while designing and implementing a virtual telemonitoring COVID-19 clinic for obstetric patients. All patients with suspected for confirmed COVID-19 were referred and enrolled. Telehealth visits were conducted every 24 to 72 hours based on the severity of symptoms and care was escalated to in person when necessary. The outcome of the majority (96.1%) of telehealth visits was to continue outpatient management. With regard to escalation of care, 25 patients (26.6%) presented for in person evaluation and five patients (5.3%) required inpatient admission. A virtual telemonitoring clinic for obstetric patients with mild COVID-19 offers an effective surveillance strategy as it allows for close monitoring, direct connection to in person evaluation, minimization of patient and provider exposure, and scalability. url: https://api.elsevier.com/content/article/pii/S0146000520300689 doi: 10.1016/j.semperi.2020.151285 id: cord-328438-irjo0l4s author: Krittanawong, Chayakrit title: Integration of novel monitoring devices with machine learning technology for scalable cardiovascular management date: 2020-10-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Ambulatory monitoring is increasingly important for cardiovascular care but is often limited by the unpredictability of cardiovascular events, the intermittent nature of ambulatory monitors and the variable clinical significance of recorded data in patients. Technological advances in computing have led to the introduction of novel physiological biosignals that can increase the frequency at which abnormalities in cardiovascular parameters can be detected, making expert-level, automated diagnosis a reality. However, use of these biosignals for diagnosis also raises numerous concerns related to accuracy and actionability within clinical guidelines, in addition to medico-legal and ethical issues. Analytical methods such as machine learning can potentially increase the accuracy and improve the actionability of device-based diagnoses. Coupled with interoperability of data to widen access to all stakeholders, seamless connectivity (an internet of things) and maintenance of anonymity, this approach could ultimately facilitate near-real-time diagnosis and therapy. These tools are increasingly recognized by regulatory agencies and professional medical societies, but several technical and ethical issues remain. In this Review, we describe the current state of cardiovascular monitoring along the continuum from biosignal acquisition to the identification of novel biosensors and the development of analytical techniques and ultimately to regulatory and ethical issues. Furthermore, we outline new paradigms for cardiovascular monitoring. url: https://doi.org/10.1038/s41569-020-00445-9 doi: 10.1038/s41569-020-00445-9 id: cord-287376-wxldnlih author: Krüger, Colin M. title: Can surgery follow the dictates of the pandemic “keep your distance”? Requirements with COVID-19 for hygiene, resources and the team date: 2020-08-03 words: 3977.0 sentences: 218.0 pages: flesch: 46.0 cache: ./cache/cord-287376-wxldnlih.txt txt: ./txt/cord-287376-wxldnlih.txt summary: Finally, the choice of surgical method, whether open surgery or minimally invasive procedures, is critical in determining how many colleagues are exposed to the risk of infection from COVID-19 patients, sometimes for hours. Here, robot-assisted surgery can comply with the pandemic''s requirement to "keep your distance" in a unique way, since the surgeon can operate at virtually any distance from the surgical site, at least with regard to aerosol formation and exposure. There were two central factors in the German hospital landscape that led to the restrictions described below: First, the call by the German Federal Ministry of Health to substantially increase the number of intensive care beds which would allow invasive ventilation of patients by temporarily postponing elective procedures; and second, the shortage of personal protective equipment (PPE), which is mainly produced in China, that accompanied the beginning of the pandemic. abstract: Since the beginning of the pandemic, there have been restrictions in the daily care of surgical patients – both elective and emergency. Readying supply capacities and establishing isolation areas and areas for suspected cases in the clinics have led to keeping beds free for treating (suspected) COVID-19 cases. It was therefore necessary to temporarily postpone elective surgery. Now, elective care can be gradually resumed with the second phase of the pandemic in Germany. However, it remains the order of the day to adapt pre-, intra- and post-operative procedures to the new COVID-19 conditions while maintaining specialized hygiene measures. This concerns the correct procedure for the use of personal protective materials as well as process adjustment for parallel treatment of positive and negative patients in the central OR, and handling of aerosols in the operating theater, operating room, and surgical site under consideration of staff and patient protection. Although dealing with surgical smoke in the operating theater has long been criticized, COVID-19 is forcing a renaissance in this area. Finally, the choice of surgical method, whether open surgery or minimally invasive procedures, is critical in determining how many colleagues are exposed to the risk of infection from COVID-19 patients, sometimes for hours. Here, robot-assisted surgery can comply with the pandemic’s requirement to “keep your distance” in a unique way, since the surgeon can operate at virtually any distance from the surgical site, at least with regard to aerosol formation and exposure. url: https://doi.org/10.3205/dgkh000354 doi: 10.3205/dgkh000354 id: cord-343393-8hdygwip author: Kudsi, Omar Yusef title: Robotic Low Anterior Resection for a Distal Sigmoid Colon Cancer during the COVID‐19 Pandemic – a Video Vignette date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID‐19 pandemic brings unprecedented challenges for both surgeons and patients. For patients who still require surgical management during this time, measures to decrease exposure risk during their hospitalization should be a priority. Minimally invasive approaches to low anterior resections (LAR) have been shown to result in early return of bowel function and a short length of stay. url: https://www.ncbi.nlm.nih.gov/pubmed/32790219/ doi: 10.1111/codi.15310 id: cord-303244-5tfrmsm7 author: Kugasia, Irfanali R. title: Amiodarone Toxicity Presenting with Acute Onset of Systemic Inflammatory Response Syndrome and Multiorgan Failure Mimicking Sepsis date: 2020-10-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patient: Male, 73-year-old Final Diagnosis: Amiodarone induced SIRS response and organizing pneumonia Symptoms: Abdominal pain • fever • nausea • vomiting Medication: — Clinical Procedure: Bronchoalveolar lavage • bronchoscopy • trans-bronchial biopsy Specialty: Critical Care Medicine OBJECTIVE: Unusual clinical course BACKGROUND: Amiodarone, an anti-arrhythmic medication, has been associated with the development of multiple organ toxicities. Most of these toxicities develop insidiously. However, in rare cases, these toxicities manifest with more acute symptoms. We present an unusual case of amiodarone toxicity which manifested with multiorgan failure and systemic inflammatory response syndrome that mimicked sepsis. CASE REPORT: A 73-year-old man who was being treated with chronic oral amiodarone for atrial fibrillation presented with flu-like symptoms and fever, pulmonary infiltrate, acute kidney injury, and thrombocytopenia. The patient did not improve with antibiotics and fluid resuscitation. The results of an extensive infectious and non-infectious workup were negative. His symptoms worsened during hospitalization, which correlated with the loading of intravenous amiodarone given for his acute worsening of atrial fibrillation. Amiodarone-induced drug toxicity was contemplated by the treating medical team. Amiodarone was stopped, and the patient was treated with steroids, which improved his symptoms and organ dysfunctions. Subsequent bronchoscopy with lung biopsy showed foamy macrophages with organizing pneumonia and fibrinoid changes. CONCLUSIONS: This case highlights an atypical and rare presentation of a complication of chronic amiodarone use that presented with acute onset of fever, systemic inflammatory response syndrome, and multiorgan failure masquerading as sepsis. The patient’s symptoms and organ dysfunctions improved with the discontinuation of amiodarone and institution of steroids. url: https://doi.org/10.12659/ajcr.926929 doi: 10.12659/ajcr.926929 id: cord-331434-2x9m37cw author: Kumar Jain, Vijay title: Fracture management during COVID-19 pandemic: A systematic review and meta-analysis date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: The COVID-19 pandemic has affected orthopedic practices worldwide. Few studies focusing on epidemiology and management of fractures in COVID 19 patients have been published. We conducted a systematic review and meta-analysis to evaluate the fracture types, presentation, treatment, complications, and early outcomes of fractures occurring amidst COVID-19 pandemic. METHODS: A systematic review and meta-analysis of the all published papers was conducted with a comprehensive search of PubMed, Google Scholar, Scopus, and Cochrane Library database using keywords ‘COVID-19’, ‘Coronavirus’, ‘trauma*'and ‘fracture’ from January–April 2020. RESULTS: The searches yielded a total of ten studies with 112 Patients who were positive for COVID 19 associated with fractures. Individual patient data meta-analysis was performed as feasible, for six studies, reporting data separately for 44 patients with COVID 19 and an associated fracture. Meta-analysis showed that a diagnosis of COVID 19 was made on the basis of positive Computed Tomography scan in 39 patients and 30 patients had a positive Reverse Transcription-Polymerase Chain Reaction test. Overall, there were 29 proximal femoral fractures, 8 spine fractures, 7 fractures of the other bones. The fractures were treated surgically in 30 cases (68.18%) and the remaining 14 cases (31.82%) were managed conservatively. There were 16 patients (36.36%) who died, mostly due to respiratory failure with a median age of 82 years. CONCLUSION: COVID-19 has led to a significant reduction in a load of fracture patients globally, though the incidence of fragility fractures continues to be unaffected. There is a significantly higher risk of mortality in elderly patients with fractures and hence they should only be operated in a facility with a robust intensive care. Conservative treatment should be adopted as far as possible in non-obligatory fractures and in lesser equipped centers. Surgery in patients with proximal femur fragility fractures when judiciously selected did result in improvement in respiratory status. Reorganizing medical services is vital to deliver effective fracture care and also mitigate disease transmission. url: https://api.elsevier.com/content/article/pii/S097656622030268X doi: 10.1016/j.jcot.2020.06.035 id: cord-330869-k5ro0edf author: Kumar Singh, Awadhesh title: Assessment of risk, severity, mortality, glycemic control and antidiabetic agents in patients with diabetes and COVID-19: A Narrative Review date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Aims Rising prevalence of non-communicable diseases world-wide has made diabetes an important comorbidity in patients with coronavirus disease-19 (COVID-19). We sought to review the risk, severity and mortality in COVID-19 and its relation to glycemic control and role of anti-diabetic agents in patients with diabetes. Methods A Boolean search was made in PubMed, MedRxiv and Google Scholar database until May 10, 2020 and full articles with supplementary appendix were retrieved using the specific key words related to the topic. Results There is a high prevalence of diabetes in patients with COVID-19. Patients with diabetes had a significantly more severe variety of COVID-19 and increased mortality, compared to the groups without diabetes. Moreover, poor glycemic control is associated with a significantly higher severe variety of COVID-19 and increased mortality, compared to the well-controlled glycemic groups. No data currently available for or against any anti-diabetic agents in COVID-19. Conclusions Diabetes, in particular poorly-controlled group is associated with a significantly higher risk of severe COVID-19 and mortality. This calls for an optimal glycemic control and an increased emphasis on future preventative therapies including the vaccination programs for these groups in addition to the traditional risk prevention such as social distancing and self-isolation. url: https://doi.org/10.1016/j.diabres.2020.108266 doi: 10.1016/j.diabres.2020.108266 id: cord-299621-m4kdkmey author: Kumar, A. title: Outbreak of Middle East respiratory syndrome coronavirus, Saudi Arabian experience date: 2017-08-31 words: 1869.0 sentences: 84.0 pages: flesch: 41.0 cache: ./cache/cord-299621-m4kdkmey.txt txt: ./txt/cord-299621-m4kdkmey.txt summary: Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified from a 60-year-old Saudi male patient admitted to a private hospital in Jeddah, Saudi Arabia on June13, 2012, with history of fever, cough, expectoration, and shortness of breath who eventually expired 11 days after admission from progressive respiratory failure. In April 2012, a cluster of cases of pneumonia occurred in health care workers of an intensive care unit in a hospital in Zarqa, Jordan, of which 2 patients died, both of whom were confirmed to be infected with the novel coronavirus by retrospective analysis of stored sample. New respiratory illness room with portable High efficiency particulate arrestors (HEPA) was created to isolate suspected MERS-CoV infected patients within the Emergency Medical Services. Until date (July 2017), there are no healthcare associated MERS-CoV Infection among patients, visitors and HCWs of our hospital and improved compliance with the IPC policies and procedures were achieved. abstract: Abstract Objective MERS-CoV infection is uncommonly identified among patients visiting healthcare facilities & we were vigilant in screening all patients entering our hospital to prevent cross infection among patients, visitors & healthcare providers and aiming to prevent potential outbreaks with MERS-CoV infection. In spite of our efforts on practicing Failure Mode Effect Analysis for MERS-CoV infection management we ended up having an outbreak with MERS-CoV. Based on our experience, we actively implemented policies, procedures & practices on early identification & appropriate isolation practices along with supplemental infection prevention & control measures for preventing future outbreaks at our healthcare facility. Methods Retrospectively we analyzed our failure in preventing the outbreak of MERS-CoV infection among our hospitalized patients by identifying the outbreak & actively intervening as a team to control the outbreak with the support of Hospital Higher management, Administrators, Quality improvement team, Infection prevention & control team & the active support of all healthcare workers of the facility. Results Following the early identification of MERS-CoV outbreak, we could successfully prevent large scale outbreak both in the hospital & the community. Conclusion Continuous implementation of infection prevention & control standards along with early clinical diagnosis of MERS-CoV infections based on the case definition as laid out by the Ministry of Health will prevent infectious outbreaks at healthcare facilities. url: https://doi.org/10.1016/j.cmrp.2017.07.006 doi: 10.1016/j.cmrp.2017.07.006 id: cord-257884-5exwwxin author: Kumar, Rajesh title: Acute pericarditis as a primary presentation of COVID-19 date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic is a highly contagious viral illness which conventionally manifests primarily with respiratory symptoms. We report a case whose first manifestation of COVID-19 was pericarditis, in the absence of respiratory symptoms, without any serious complications. Cardiac involvement in various forms is possible in COVID-19. We present a case where pericarditis, in the absence of the classic COVID-19 signs or symptoms, is the only evident manifestation of the disease. This case highlights an atypical presentation of COVID-19 and the need for a high index of suspicion to allow early diagnosis and limit spread by isolation. url: https://www.ncbi.nlm.nih.gov/pubmed/32816925/ doi: 10.1136/bcr-2020-237617 id: cord-334324-remrcm2q author: Kunal, Shekhar title: Cardiovascular complications and its impact on outcomes in COVID-19 date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) has led to a widespread morbidity and mortality. Limited data exists regarding the involvement of cardiovascular system in COVID-19 patients. We sought to evaluate the cardiovascular (CV) complications and its impact on outcomes in symptomatic COVID-19 patients. METHODS: This was a single center observational study among symptomatic COVID-19 patients. Data regarding clinical profile, laboratory investigations, CV complications, treatment and outcomes were collected. Cardiac biomarkers and 12 lead electrocardiograms were done in all while echocardiography was done in those with clinical indications for the same. Corrected QT-interval (QTc) at baseline and maximum value during hospitalization were computed. RESULTS: Of the 108 patients, majority of them were males with a mean age of 51.2 ± 17.7 years. Hypertension (38%) and diabetes (32.4%) were most prevalent co-morbidities. ECG findings included sinus tachycardia in 18 (16.9%), first degree AV block in 5 (4.6%), VT/VF in 2 (1.8%) and sinus bradycardia in one (0.9%). QTc prolongation was observed in 17.6% subjects. CV complications included acute cardiac injury in 25.9%, heart failure, cardiogenic shock and acute coronary syndrome in 3.7% each, “probable” myocarditis in 2.8% patients. Patients with acute cardiac injury had higher mortality than those without (16/28 [57.1%] vs 14/78 [17.5%]; P < 0.0001). Multivariate logistic regression analysis showed that acute cardiac injury (OR: 11.3), lymphopenia (OR: 4.91), use of inotropic agents (OR: 2.46) and neutrophil-lymphocyte ratio (OR:1.1) were independent predictors of mortality. CONCLUSIONS: CV complications such as acute cardiac injury is common in COVID-19 patients and is associated with worse prognosis. url: https://www.sciencedirect.com/science/article/pii/S0019483220302662?v=s5 doi: 10.1016/j.ihj.2020.10.005 id: cord-278592-67y4f9av author: Kurup, Asok title: Control of a hospital-wide vancomycin-resistant Enterococci outbreak date: 2008-03-24 words: 3037.0 sentences: 174.0 pages: flesch: 49.0 cache: ./cache/cord-278592-67y4f9av.txt txt: ./txt/cord-278592-67y4f9av.txt summary: To eradicate a hospital-wide outbreak, a coordinated strategy between March and June 2005 comprised (1) formation of a VRE task force, (2) hospital-wide screening, (3) isolation of carriers, (4) physical segregation of contacts, (5) surveillance of high-risk groups, (6) increased cleaning, (7) electronic tagging of VRE status, and (8) education and audits. 1 In 2004, a localized VRE outbreak in a hematology ward of Singapore General Hospital (SGH) involving 6 inpatients was blamed on overseas importation of the index case with breaches in infection control measures, resulting in subsequent dissemination in that ward. Patients with high-risk acquisition for VRE-like end-stage renal failure (ESRF) on dialysis, those with hematologic or oncologic malignancies, those transferred from other local or overseas hospitals, or those with hospital admissions after January 1, 2005 were defined as ''''unknowns.'''' Records of ''''contacts'''' and ''''unknowns'''' were electronically tagged to facilitate VRE screening by stool or rectal swab on 2 separate occasions at least 24 hours apart. abstract: BACKGROUND: To analyze control measures used to eradicate a large vancomycin-resistant Enterococci (VRE) outbreak in a nonendemic 1600-bed tertiary care institution. METHODS: In mid-March 2005, VRE Van B was isolated from 2 clinical samples from different wards. Despite such measures as screening patients sharing rooms with index cases and isolating VRE patients, 43 isolates from different wards were detected by the end of March 2005. To eradicate a hospital-wide outbreak, a coordinated strategy between March and June 2005 comprised (1) formation of a VRE task force, (2) hospital-wide screening, (3) isolation of carriers, (4) physical segregation of contacts, (5) surveillance of high-risk groups, (6) increased cleaning, (7) electronic tagging of VRE status, and (8) education and audits. This is a retrospective study of this multipronged approach to containing VRE. The adequacy of rectal swab sampling for VRE was assessed in a substudy of 111 patients. The prevalence of methicillin-resistant Staphylococcus aureus (MRSA)/VRE co-colonization or co-infection also was determined. RESULTS: A total of 19,574 contacts were identified. Between April and June 2005, 5095 patients were screened, yielding 104 VRE carriers, 54 of whom (52%) were detected in the first 2 weeks of hospital-wide screening. The initial positive yield of 11.4% of persons actively screened declined to 4.2% by the end of June 2005. Pulsed-field typing revealed 1 major clone and several minor clones among the 151 total VRE cases, including 4 clinical cases. Hospital-wide physical segregation of contacts from other patients was difficult to achieve in communal wards. Co-colonization or co-infection with MRSA, which was present in 52 of 151 cases (34%) and the indefinite electronic tagging of positive VRE status strained limited isolation beds. Analysis of 2 fecal or rectal specimens collected 1 day apart may detect at least 83% of VRE carriers. CONCLUSION: A multipronged strategy orchestrated by a central task force curbed but could not eradicate VRE. Control measures were confounded by hospital infrastructure and high MRSA endemicity. url: https://api.elsevier.com/content/article/pii/S0196655307007195 doi: 10.1016/j.ajic.2007.06.005 id: cord-351155-5bvo66yb author: Kushner, Tatyana title: Chronic Liver Disease and COVID‐19: Alcohol Use Disorder/Alcohol‐Associated Liver Disease, Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Autoimmune Liver Disease, and Compensated Cirrhosis date: 2020-05-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32537135/ doi: 10.1002/cld.974 id: cord-322066-m8dphaml author: Kutscher, Eric title: Primary Care Providers: Discuss COVID-19-Related Goals of Care with Your Vulnerable Patients Now date: 2020-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32378009/ doi: 10.1007/s11606-020-05862-7 id: cord-311418-7core0y3 author: Kutsenko, Oleksandra title: Guest Editorial: Radiology Nurses Can Raise the Impact on Promoting IR date: 2020-04-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S1546084320300468 doi: 10.1016/j.jradnu.2020.03.003 id: cord-337965-z39q8ebq author: Kvernland, Alexandra title: Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System date: 2020-08-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND AND PURPOSE: While the thrombotic complications of COVID-19 have been well described, there are limited data on clinically significant bleeding complications including hemorrhagic stroke. The clinical characteristics, underlying stroke mechanism, and outcomes in this particular subset of patients are especially salient as therapeutic anticoagulation becomes increasingly common in the treatment and prevention of thrombotic complications of COVID-19. METHODS: We conducted a retrospective cohort study of patients with hemorrhagic stroke (both non-traumatic intracerebral hemorrhage and spontaneous non-aneurysmal subarachnoid hemorrhage) who were hospitalized between March 1, 2020, and May 15, 2020, within a major healthcare system in New York, during the coronavirus pandemic. Patients with hemorrhagic stroke on admission and who developed hemorrhage during hospitalization were both included. We compared the clinical characteristics of patients with hemorrhagic stroke and COVID-19 to those without COVID-19 admitted to our hospital system between March 1, 2020, and May 15, 2020 (contemporary controls), and March 1, 2019, and May 15, 2019 (historical controls). Demographic variables and clinical characteristics between the individual groups were compared using Fischer’s exact test for categorical variables and nonparametric test for continuous variables. We adjusted for multiple comparisons using the Bonferroni method. RESULTS: During the study period in 2020, out of 4071 patients who were hospitalized with COVID-19, we identified 19 (0.5%) with hemorrhagic stroke. Of all COVID-19 with hemorrhagic stroke, only three had isolated non-aneurysmal SAH with no associated intraparenchymal hemorrhage. Among hemorrhagic stroke in patients with COVID-19, coagulopathy was the most common etiology (73.7%); empiric anticoagulation was started in 89.5% of these patients versus 4.2% in contemporary controls (p ≤ .001) and 10.0% in historical controls (p ≤ .001). Compared to contemporary and historical controls, patients with COVID-19 had higher initial NIHSS scores, INR, PTT, and fibrinogen levels. Patients with COVID-19 also had higher rates of in-hospital mortality (84.6% vs. 4.6%, p ≤ 0.001). Sensitivity analyses excluding patients with strictly subarachnoid hemorrhage yielded similar results. CONCLUSION: We observed an overall low rate of imaging-confirmed hemorrhagic stroke among patients hospitalized with COVID-19. Most hemorrhages in patients with COVID-19 infection occurred in the setting of therapeutic anticoagulation and were associated with increased mortality. Further studies are needed to evaluate the safety and efficacy of therapeutic anticoagulation in patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32839867/ doi: 10.1007/s12028-020-01077-0 id: cord-259969-q65k590s author: Kösters, Katrin title: Cutaneous Vasculitis in a Patient With COVID-19 date: 2020-10-05 words: 824.0 sentences: 59.0 pages: flesch: 43.0 cache: ./cache/cord-259969-q65k590s.txt txt: ./txt/cord-259969-q65k590s.txt summary: We describe a 43-year-old patient with coronavirus disease 2019 who developed a bullous hemorrhagic rash that progressed to necrotic lesions. Small blood vessel occlusion by microthrombi, which has been described in patients with coronavirus disease 2019 (COVID-19) [1] , could not be demonstrated. Under suspicion of a SARS-CoV-2-induced cutaneous vasculitis, the patient was treated with prednisolone at 0.5 mg per kilogram. Variable and heterogenous skin manifestations in patients with COVID-19 have been described that appear before, during, and after the disease [2] . However, other groups have described skin manifestations in up to 20% of COVID patients [4, 5] . However, our case demonstrates a small/medium-sized vessel vasculitis with involvement of mucous membranes as the cause of skin manifestations in a patient with COVID-19 that appeared late in the disease. Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging issue abstract: We describe a 43-year-old patient with coronavirus disease 2019 who developed a bullous hemorrhagic rash that progressed to necrotic lesions. Histopathology confirmed a vasculitis of small- and medium-sized cutaneous vessels. url: https://doi.org/10.1093/ofid/ofaa474 doi: 10.1093/ofid/ofaa474 id: cord-296605-p67twx7a author: LAU, Arthur Chun-Wing title: Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) date: 2004-03-10 words: 4846.0 sentences: 247.0 pages: flesch: 38.0 cache: ./cache/cord-296605-p67twx7a.txt txt: ./txt/cord-296605-p67twx7a.txt summary: title: Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) Most SARS patients would require high flow oxygen supplementation, 20–30% required intensive care unit (ICU) or high dependency care, and 13–26% developed acute respiratory distress syndrome (ARDS). The management of critically ill SARS patients requires timely institution of pharmacotherapy where applicable and supportive treatment (oxygen therapy, noninvasive and invasive ventilation). More than onethird of all the SARS patients required high flow oxygen therapy [4] , 20-30% required intensive care unit (ICU) admission or high dependency care, and 13-26% developed acute respiratory distress syndrome (ARDS) [5, 6] . Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China Evaluation of non-invasive positive pressure ventilation in treatment for patients with severe acute respiratory syndrome Clinical observation of non-invasive positive pressure ventilation (NIPPV) in the treatment of severe acute respiratory syndrome (SARS) abstract: Severe acute respiratory syndrome (SARS) is frequently complicated with acute respiratory failure. In this article, we aim to focus on the management of the subgroup of SARS patients who are critically ill. Most SARS patients would require high flow oxygen supplementation, 20–30% required intensive care unit (ICU) or high dependency care, and 13–26% developed acute respiratory distress syndrome (ARDS). In some of these patients, the clinical course can progress relentlessly to septic shock and/or multiple organ dysfunction syndrome (MODS). The management of critically ill SARS patients requires timely institution of pharmacotherapy where applicable and supportive treatment (oxygen therapy, noninvasive and invasive ventilation). Superimposed bacterial and other opportunistic infections are common, especially in those treated with mechanical ventilation. Subcutaneous emphysema, pneumothoraces and pneumomediastinum may arise spontaneously or as a result of positive ventilatory assistance. Older age is a consistently a poor prognostic factor. Appropriate use of personal protection equipment and adherence to infection control measures is mandatory for effective infection control. Much of the knowledge about the clinical aspects of SARS is based on retrospective observational data and randomized-controlled trials are required for confirmation. Physicians and scientists all over the world should collaborate to study this condition which may potentially threaten human existence. url: https://www.ncbi.nlm.nih.gov/pubmed/15912185/ doi: nan id: cord-311838-ymn96yj4 author: LIU)刘茜玮(, Qianwei title: Analysis of the Influence of the Psychology Changes of Fear Induced by the COVID-19 Epidemic on the Body date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In this paper, the theory of " Fear injury kidney " in traditional Chinese medicine is systematically reviewed, and it is found that long-term or excessive psychological changes of fear are likely to damage kidney qi and kidney essence. On this basis, the psychological studies of patients, medical staff and the public during the COVID-19 epidemic in China were analyzed, and fear psychology was found to be prevalent among all kinds of people. Modern researches on “Fear injury kidney" have also found that long-term or excessive fear could cause changes in the neuro-endocrine-immune system, which can induce diseases or susceptibility to some diseases. Therefore, during or after the prevalence of COVID-19, different groups of people may have emotional reactions such as stress and fear, which should be paid long-term attention, and the influence of fear on the body cannot be ignored. According to the change rule of psychological state under stress reaction, we should actively respond to and take psychological crisis intervention measures in time to reduce the harm of psychological stress to the body. url: https://www.sciencedirect.com/science/article/pii/S1003525720300799?v=s5 doi: 10.1016/j.wjam.2020.06.007 id: cord-322497-hdy3va8e author: LUBANSU, Alphonse title: COVID-19 impact on neurosurgical practice: lockdown attitude and experience of a European academic center. date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction The Coronavirus disease 2019 (COVID-19) pandemic is an unprecedented challenge. Different models of reorganization have been described aiming to preserve resources while ensuring optimal medical care. limited clinical neurosurgical experience including COVID-19 patients have been reported. We share organizational experience, attitudes, and preliminary data of patients treated at our institution. Methods Institutional guidelines and patient workflow are described and visualized. A cohort of all neurosurgical patients managed during the lockdown period is presented and analyzed assessing suspected nosocomial infection risk factors. A comparative surgical subcohort from the previous year was used to investigate the impact on surgical activity. Results A total of 176 patients were admitted in 66 days, twenty tested positive for COVID-19. Patients initially admitted to the neurosurgical ward were less likely to be suspected for a COVID-19 infection when compared to patients admitted for critical emergencies, particularly with neurovascular and stroke-related pathologies. The mortality rate of COVID-19 patients was remarkably high (45%), and even higher in patients that underwent surgical intervention (77 %). In addition to the expected drop in surgical activity (-53%), a decrease in traumatic emergencies was noted. Conclusion By applying infection prevention and resource-sparing logistics measures shared by the international medical community, we were able to maintain essential neurosurgical care in a pandemic with controlled nosocomial infection risk. Special consideration should be given to medical management and surgical indications in patients infected with the SARS-CoV-2 virus, as they seem to exhibit a problematic hemostatic profile that might result in an unfavorable clinical and surgical outcome. url: https://doi.org/10.1016/j.wneu.2020.08.168 doi: 10.1016/j.wneu.2020.08.168 id: cord-338968-b1gg2ha7 author: La Rosée, Felicitas title: Ruxolitinib in COVID-19 Hyperinflammation and Haematologic Malignancies date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1159/000510770 doi: 10.1159/000510770 id: cord-340710-dmow5p7k author: Lagana, Stephen M. title: Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus SARS-CoV-2 (coronavirus disease 19, or COVID-19) primarily causes pulmonary injury, but has been implicated to cause hepatic injury, both by serum markers and histologic evaluation. The histologic pattern of injury has not been completely described. Studies quantifying viral load in the liver are lacking. Here we report the clinical and histologic findings related to the liver in 40 patients who died of complications of COVID-19. A subset of liver tissue blocks were subjected to polymerase chain reaction (PCR) for viral ribonucleic acid (RNA). Peak levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were elevated; median ALT peak 68 U/l (normal up to 46 U/l) and median AST peak 102 U/l (normal up to 37 U/l). Macrovesicular steatosis was the most common finding, involving 30 patients (75%). Mild lobular necroinflammation and portal inflammation were present in 20 cases each (50%). Vascular pathology, including sinusoidal microthrombi, was infrequent, seen in six cases (15%). PCR of liver tissue was positive in 11 of 20 patients tested (55%). In conclusion, we found patients dying of COVID-19 had biochemical evidence of hepatitis (of variable severity) and demonstrated histologic findings of macrovesicular steatosis and mild acute hepatitis (lobular necroinflammation) and mild portal inflammation. We also identified viral RNA in a sizeable subset of liver tissue samples. url: https://doi.org/10.1038/s41379-020-00649-x doi: 10.1038/s41379-020-00649-x id: cord-352828-4ecik6xw author: Lagziel, Tomer title: Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The recent outbreak of COVID-19 has put significant strain on the current health system and has exposed dangers previously overlooked. The pathogen known as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is notable for attacking the pulmonary system causing acute respiratory distress, but it can also severely affect other systems in at-risk individuals including cardiovascular compromise, gastrointestinal distress, acute kidney injury, coagulopathies, cutaneous manifestations, and ultimately death from multi-organ failure. Unfortunately, the reliability of negative test results is questionable and the high infectious burden of the virus calls for extended safety precautions, especially in symptomatic patients. We present a confirmed COVID-19 case that was transferred to our burn center for concern of Steven Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap syndrome after having two negative confirmatory COVID-19 tests at an outside hospital. A 58-year-old female with a history of morbid obesity, HTN, gout, CML managed with imatinib, and chronic kidney disease presented as a transfer from a community hospital to our burn center. The patient was admitted to her community hospital with febrile, acute respiratory distress. Imaging and clinical presentation was consistent with COVID-19 and lab tests for the pathogen were ordered. During observation, while waiting for results, she was placed under patient under investigation (PUI) protocol. Once negative results were obtained, the PUI protocol was abandoned despite ongoing symptoms. Subsequently, dermatological symptoms developed and transfer to our burn center was initiated. After a second negative test result, the symptomatic patient was transferred to our burn center for expert wound management. Given the lack of resolve of respiratory symptoms and concern for the burn patient population, the patient was placed in PUI protocol and an internal COVID-19 was ordered. The patient’s initial exam under standard COVID-19 airborne precautions revealed 5% total body surface area of loss of epidermis affecting bilateral thighs, bilateral arms, and face. A dermatopathological biopsy suggested a bullous drug reaction with an erythema multiform-like reaction pattern versus SJS/TEN. Moreover, the internal COVID-19 test returned positive. The delayed positive test results and complicated hospital course with our patient required us to scale back and notify every patient and staff member whom they came in contact with, across multiple institutions. We suggest that whenever a suspected COVID-19 patient is transferred to a specialized center, they should be isolated and re-checked before joining the new patient population for treatment of the unique condition. url: https://doi.org/10.7759/cureus.8198 doi: 10.7759/cureus.8198 id: cord-253704-y0t30xw3 author: Lahiri, Durjoy title: COVID-19 Pandemic: A Neurological Perspective date: 2020-04-29 words: 4348.0 sentences: 210.0 pages: flesch: 40.0 cache: ./cache/cord-253704-y0t30xw3.txt txt: ./txt/cord-253704-y0t30xw3.txt summary: Even though severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed to principally affect the respiratory system, neurological involvements have already been reported in some published work. Neurological manifestations can further be subdivided into the central nervous system (headache, dizziness, alteration of the sensorium, ataxia encephalitis, stroke, and seizures) and peripheral nervous system (skeletal muscle injury and peripheral nerve involvement including hyposmia and hypogeusia) symptomatology. Even though severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed to mainly affect the respiratory system, neurological involvements have already been reported in some published work. In the present paper, we have reviewed the recently published or pre-print original articles, case reports, and existing open-source data-sets in order to delineate the spectrum of neurological disorders in SARS-CoV-2 positive cases. Another report from China describes a case of acute myelitis, possibly affecting the cervical spinal cord, as evidenced by the clinical features, in a known patient of SARS-CoV-2 infection [22] . abstract: Even though severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed to principally affect the respiratory system, neurological involvements have already been reported in some published work. We have reviewed original articles, case reports, and existing open-source data-sets to delineate the spectrum of neurological disorders potentially observed in SARS-CoV-2 positive cases. Neurological involvement in coronavirus disease 2019 (COVID-19) corresponds to three situations: (a) neurological manifestations of viral infection, (b) post-infective neurological complications, and (c) infection in patients with neurological co-morbidity. Neurological manifestations can further be subdivided into the central nervous system (headache, dizziness, alteration of the sensorium, ataxia encephalitis, stroke, and seizures) and peripheral nervous system (skeletal muscle injury and peripheral nerve involvement including hyposmia and hypogeusia) symptomatology. Post-infective neurological complications include demyelinating conditions. Reduced mobility and dementia as co-morbidities may predispose a patient to have a viral infection. It is concluded that the pandemic of COVID-19 presents for a neurologist some unique challenges. We observe that SARS-CoV-2 may have various neurological manifestations and in many cases, neurological features may precede typical respiratory symptoms. url: https://doi.org/10.7759/cureus.7889 doi: 10.7759/cureus.7889 id: cord-325793-5vrr7msw author: Lahiry, Anup K. title: Dermatosurgery Practice and Implications of COVID-19 Pandemic: Recommendations by IADVL SIG Dermatosurgery (IADVL Academy) date: 2020-05-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32695688/ doi: 10.4103/idoj.idoj_237_20 id: cord-282780-34j7gquo author: Lai, Kevin E. title: Tele-Neuro-Ophthalmology During the Age of COVID-19 date: 2020-06-26 words: 6297.0 sentences: 292.0 pages: flesch: 46.0 cache: ./cache/cord-282780-34j7gquo.txt txt: ./txt/cord-282780-34j7gquo.txt summary: In addition, a physician can use phone visits to triage visual symptoms with a normal dilated eye examination by another provider or discuss medication compliance and tolerance, neuroimaging findings, and laboratory test results. Before COVID-19, a telemedicine visit might follow an initial in-person visit: the patient could complete local visual field testing, fundus photographs, OCT, and/or MRI, and then review the results with the neuro-ophthalmologist over phone or video as the case history is discussed. Patients who have Apple iPhone 7 Plus or who do not have an assistant available can use "Vision@home," an online test validated for both near (40 cm) and distance (2 m, assistant needed) visual acuities that is accessible free on their phone browser at www.visionathome.com.au (9) . Conceptually, technological privacy and security refer to how the user (doctor-patient), the company providing the platform (e.g., Zoom and Google), and everyone else on the internet (external parties) relate to each other (see Supplemental Digital Content 15, Figure E8 , http://links.lww. abstract: Supplemental Digital Content is Available in the Text. url: https://doi.org/10.1097/wno.0000000000001024 doi: 10.1097/wno.0000000000001024 id: cord-034303-kcu9guxa author: Laimoud, Mohamed title: The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date: 2020-10-27 words: 3194.0 sentences: 170.0 pages: flesch: 44.0 cache: ./cache/cord-034303-kcu9guxa.txt txt: ./txt/cord-034303-kcu9guxa.txt summary: The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating hospital mortality and neurological outcome after VA-ECMO support for adult patients with cardiogenic shock. The non-survivors and the patients with acute cerebral strokes had significantly higher arterial lactate levels at pre-ECMO initiation, post-ECMO peak and after 24 h of ECMO support compared to the survivors and those without strokes, respectively. CONCLUSION: Progressive hyperlactatemia after VA-ECMO initiation for adult patients with cardiogenic shock is a sensitive and specific predictor of hospital mortality and acute cerebrovascular strokes. The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating in-hospital mortality and neurological outcome after VA-ECMO support for patients with cardiogenic shock. Finally, our study revealed that the hospital mortality and neurological outcome of VA-ECMO were significantly associated with the severity of pre-ECMO shock state and the appropriate recovery of organs perfusion after ECMO support as indicated with changes of blood lactate levels. abstract: BACKGROUND: Veno-arterial ECMO is a life-supporting procedure that can be done to the patients with cardiogenic shock which is associated with hyperlactatemia. The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating hospital mortality and neurological outcome after VA-ECMO support for adult patients with cardiogenic shock. All consecutive patients ≥ 18 years admitted with cardiogenic shock and supported with VA-ECMO between 2015 and 2019 in our tertiary care hospital were retrospectively studied. RESULTS: The study included 106 patients with a mean age of 40.2 ± 14.4 years, a mean BMI of 26.5 ± 7 and mostly males (69.8%). The in-hospital mortality occurred in 56.6% and acute cerebral strokes occurred in 25.5% of the enrolled patients. The non-survivors and the patients with acute cerebral strokes had significantly higher arterial lactate levels at pre-ECMO initiation, post-ECMO peak and after 24 h of ECMO support compared to the survivors and those without strokes, respectively. The peak arterial lactate ≥ 14.65 mmol/L measured after ECMO support had 81.7% sensitivity and 89.1% specificity for predicting hospital mortality [AUROC 0.889, p < 0.001], while the arterial lactate level ≥ 3.25 mmol/L after 24 h of ECMO support had 88.3% sensitivity and 97.8% specificity for predicting hospital mortality [AUROC 0.93, p < 0.001]. The peak lactate ≥ 15.15 mmol/L measured after ECMO support had 70.8% sensitivity and 69% specificity for predicting cerebral strokes [AUROC 0.717, p < 0.001], while the lactate level ≥ 3.25 mmol/L after 24 h of ECMO support had 79.2% sensitivity and 72.4% specificity for predicting cerebral strokes [AUROC 0.779, p < 0.001]. Progressive hyperlactatemia (OR = 1.427, 95% CI 1.048–1.944, p = 0.024) and increasing SOFA score after 48 h (OR = 1.819, 95% CI 1.374–2.409, p < 0.001) were significantly associated with in-hospital mortality after VA-ECMO support. Post hoc analysis detected a significantly high frequency of hypoalbuminemia in the non-survivors and in the patients who developed acute cerebral strokes during VA-ECMO support. CONCLUSION: Progressive hyperlactatemia after VA-ECMO initiation for adult patients with cardiogenic shock is a sensitive and specific predictor of hospital mortality and acute cerebrovascular strokes. According to our results, we could recommend early VA-ECMO initiation to achieve adequate circulatory support and better outcome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588953/ doi: 10.1186/s43044-020-00108-7 id: cord-006517-845w9r6l author: Lalueza, A. title: Impact of severe hematological abnormalities in the outcome of hospitalized patients with influenza virus infection date: 2017-05-13 words: 4068.0 sentences: 209.0 pages: flesch: 45.0 cache: ./cache/cord-006517-845w9r6l.txt txt: ./txt/cord-006517-845w9r6l.txt summary: The aim of the present study was to assess the frequency and clinical impact of hematological abnormalities in the range of those accepted by the Histyocite Society for the suspicion of HPS [19] in patients who were admitted to the hospital with a confirmed influenza virus infection. In Beutel''s study of 25 critically ill patients with influenza A (H1N1) pdm09 virus associated hemophagocytic syndrome, the absence of steroid therapy in the early phase of the infection might have contributed to the high incidence of HPS (9 out of 25 patients) and the rather poor outcomes [18] . Significant hematological abnormalities are frequently seen in patients with influenza virus infection who required hospital admission and are associated with a poor outcome. abstract: Although hematological abnormalities have been described among patients with influenza virus infection, little is known about their impact on the outcome of the patients. The aim of this study was to assess the frequency and clinical impact of severe hematological abnormalities in patients with confirmed influenza virus infection. This was an observational retrospective study including all adult patients with diagnosis of influenza virus infection hospitalized from January to May 2016 in our institution. Influenza virus infection was diagnosed by means of rRT-PCR assay performed on respiratory samples. Poor outcome was defined as a composite endpoint in which at least one of the following criteria had to be fulfilled: (a) respiratory failure, (b) SOFA ≥2, or (c) death. Two hundred thirty-nine patients were included. Applying the HLH-04 criteria for the diagnosis of hemophagocytic syndrome, cytopenias (hemoglobin ≤9 g/dl, platelets <100,000/μl or neutrophils <1,000/μl) were present in 51 patients (21%). Patients with hematological abnormalities showed higher SOFA scores, respiratory failure, septic shock and in-hospital mortality than the remaining patients. The composite endpoint was present in 33.3% in the cytopenias group vs. 13.3% in the group without cytopenias (p=0.001). In a multivariate analysis, variables associated with the composite endpoint were: use of steroids prior to present admission (OR: 0.12; 95% CI: 0.015–0.96, p=0.046), presence of any hematological abnormality (OR: 3.54; 95% CI:1.66–7.51, p= 0.001), and LDH>225 U/l (OR:4.45; CI:1–19.71, p=0.049). Hematological abnormalities are not uncommon among hospitalized patients with influenza virus infection, and they are associated with a poorer outcome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101956/ doi: 10.1007/s10096-017-2998-4 id: cord-280554-9jp85yzz author: Lamure, Sylvain title: Determinants of outcome in Covid-19 hospitalized patients with lymphoma: A retrospective multicentric cohort study date: 2020-10-13 words: 4536.0 sentences: 225.0 pages: flesch: 48.0 cache: ./cache/cord-280554-9jp85yzz.txt txt: ./txt/cord-280554-9jp85yzz.txt summary: The data obtained concerning lymphoma history included the date of diagnosis, pathological classification according to the WHO classification for lymphoid neoplasms [19] , number of treatment lines, past autologous or allogeneic stem cell transplant, chimeric antigen receptor (CAR) T-cell therapy, detailed bendamustine and anti-CD20 monoclonal antibody use (date of first and last administration), and lymphoma status at admission for Covid-19 (complete or partial remission, diagnosed at admission, under first or second line treatment, in watch and wait follow-up, or refractory/ relapsed). Covariates considered in this analysis were age ( 70 years versus below), gender, BMI ( 30 kg/m 2 versus below), smoking status, presence of comorbidities (overall or hypertension, diabetes, chronic lung disease, or past history of cancer) and ongoing antihypertensive treatment with an ACE inhibitor or angiotensin-receptor blocker (ARB), main lymphoma subtypes (Hodgkin lymphoma, B-cell non-Hodgkin lymphoma (NHL), or T-cell NHL), recent administration of corticosteroids (within one month), use of bendamustine (within one year), or anti-CD20 monoclonal antibody (within one year), time between diagnosis of lymphoma and hospitalization for Covid-19 (< 2 years versus 2 years), past history of autologous stem cell transplant, and lymphoma status (refractory/relapsed versus others). abstract: BACKGROUND: Patients with lymphoma are immunocompromised because of the disease per se and its treatments. We aimed to describe the characteristics of patients with lymphoma hospitalized for Coronavirus Disease 2019 (Covid-19) and to analyze pre-Covid-19 determinants of mortality. METHODS: This retrospective multicentric cohort study used the Programme de Médicalisation des Systèmes d'Information database to identify all adult patients with lymphoma, hospitalized for Covid-19 in March and April 2020, in 12 hospitals of three French regions with pandemic outbreaks. The characteristics of lymphoma and Covid-19 were collected from medical charts. FINDINGS: Eighty-nine patients were included. The median age was 67 years (range, 19–92), 66% were male and 72% had a comorbidity. Most patients had B-cell non-Hodgkin lymphoma (86%) and had received a lymphoma treatment within one year (70%). With a median follow-up of 33 days from admission, 30-day overall survival was 71%, (95% confidence interval, 62–81%). In multivariable analysis, having an age ≥ 70 years (hazard ratio 2·87, 1·20–6·85, p = 0·02) and relapsed/refractory lymphoma (hazard ratio 2·54, 1·14–5·66, p = 0·02) were associated with mortality. Recent bendamustine treatment (n = 9) was also pejorative (hazard ratio 3·20, 1·33–7·72, p = 0·01), but was strongly associated with relapsed/refractory lymphoma. Remarkably, 30-day overall survival for patients < 70 years of age without relapsed/refractory lymphoma was 88% (78% - 99%). INTERPRETATION: Thirty-day mortality was associated with being older and relapsed/refractory lymphoma. Survival of patients younger than 70 years without relapsed/refractory lymphoma was comparable to that of the general population. FUNDING: There have been no specific funds to run this study. url: https://api.elsevier.com/content/article/pii/S2589537020302935 doi: 10.1016/j.eclinm.2020.100549 id: cord-299124-g70v4crs author: Lancaster, Elizabeth M. title: Impact of the COVID-19 pandemic on an academic vascular practice and a multi-disciplinary limb preservation program date: 2020-09-12 words: 2176.0 sentences: 116.0 pages: flesch: 51.0 cache: ./cache/cord-299124-g70v4crs.txt txt: ./txt/cord-299124-g70v4crs.txt summary: Early analysis of patient outcomes following pandemic-related practice changes suggest that patients with chronic limb threatening ischemia (CLTI) have been presenting with more severe foot infections and are more likely to require major limb amputation compared to 6 months prior. As our society and health care system adapt to the new changes required in the post-COVID era, it is critical that we pay special attention to the most vulnerable subsets of patients with vascular disease, particularly those with CLTI and limited access to care. Faculty, fellows, and residents provide care for vascular patients at the main UCSF campus as 10 well as two partner hospitals; the San Francisco Veteran Affairs (SFVA) Medical Center and 11 Providers prioritized in-person clinic visits for patients 9 with advanced lower extremity peripheral artery disease (PAD) with concern for CLTI (e.g. new 10 tissue loss), given that physical examination and vascular studies are essential for evaluation. abstract: With the aggressive resource conservation necessary to face the COVID-19 pandemic, vascular surgeons face unique challenges to managing the health of their high-risk patients. Early analysis of patient outcomes following pandemic-related practice changes suggest that patients with chronic limb threatening ischemia (CLTI) have been presenting with more severe foot infections and are more likely to require major limb amputation compared to 6 months prior. As our society and health care system adapt to the new changes required in the post-COVID era, it is critical that we pay special attention to the most vulnerable subsets of patients with vascular disease, particularly those with CLTI and limited access to care. url: https://www.sciencedirect.com/science/article/pii/S0741521420320188?v=s5 doi: 10.1016/j.jvs.2020.08.132 id: cord-308071-1bk3xuwf author: Lang, Christian title: Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient date: 2020-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32857987/ doi: 10.1016/s2213-2600(20)30361-1 id: cord-286743-z0e5arlm author: Langer-Gould, Annette title: Early Identification of COVID-19 Cytokine Storm and Treatment with Anakinra or Tocilizumab date: 2020-08-06 words: 4258.0 sentences: 213.0 pages: flesch: 43.0 cache: ./cache/cord-286743-z0e5arlm.txt txt: ./txt/cord-286743-z0e5arlm.txt summary: Subsequently, a shift in practice by clinicians at some of our medical centers aimed to identify early COVID19-CS through laboratory abnormalities in patients with increasing O2 requirements and to initiate combined treatment with anakinra and corticosteroids occurred. Data were extracted by manual reviewing the EHR, including onset of dyspnea and other COVID-19 symptoms, age, sex, comorbidities, smoking status, tocilizumab and anakinra use, other J o u r n a l P r e -p r o o f treatments rendered for hydroxychloroquine, and/or corticosteroids) , fever (>100.4F), hypotension requiring pressors, dates of admission, intubation, extubation, discharge and/or death. The primary purpose of analyses was to describe clinical outcomes among tocilizumab-or anakinra-treated COVID-19 patients and to examine whether differences in outcomes could be accounted for by COVID19-CS severity and/or duration at the time of treatment initiation (baseline). abstract: OBJECTIVE: To examine outcomes among patients who were treated with the targeted anti-cytokine agents, anakinra or tocilizumab, for COVID-19 -related cytokine storm (COVID19-CS). METHODS: We conducted a retrospective cohort study of all SARS-coV2-RNA-positive patients treated with tocilizumab or anakinra in Kaiser Permanente Southern California. Local experts developed and implemented criteria to define COVID19-CS. All variables were extracted from the electronic health record. RESULTS: At tocilizumab initiation (n = 52), 50 (96.2%) were intubated, and only 7 (13.5%) received concomitant corticosteroids. At anakinra initiation (n = 41), 23 (56.1%) were intubated, and all received concomitant corticosteroids. Fewer anakinra-treated patients died (n = 9, 22%) and more were extubated/never intubated (n = 26, 63.4%) compared to tocilizumab-treated patients (n = 24, 46.2% dead, n = 22, 42.3% extubated/never intubated). Patients who died had more severe sepsis and respiratory failure and met COVID-CS laboratory criteria longer (median = 3 days) compared to those extubated/never intubated (median = 1 day). After accounting for differences in disease severity at treatment initiation, this apparent superiority of anakinra over tocilizumab was no longer statistically significant (propensity score-adjusted hazards ratio 0.46, 95% confidence interval 0.18–1.20). CONCLUSIONS: Prompt identification and treatment of COVID19-CS prior to intubation may be more important than the specific type of anti-inflammatory treatment. Randomized controlled trials of targeted anti-cytokine treatments and corticosteroids should report duration of cytokine storm in addition to clinical severity at randomization. url: https://api.elsevier.com/content/article/pii/S1201971220306093 doi: 10.1016/j.ijid.2020.07.081 id: cord-330963-w24q8sn7 author: Langston, Amelia A. title: Allocating Scarce Healthcare Resources during Pandemics: Making the Case for Patients with Advanced and Metastatic Cancer date: 2020-08-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The oncology community is concerned that cancer patients will be unfairly classified in pandemic allocation guidances. Past guidances either excluded metastatic cancer patients from consideration or categorized them as having a survival of less than one year. Given recent improvements in treatments, we recommend that (1)the prognosis of an individual cancer patient be determined with input from a cancer specialist, or (2) if this is impractical, (a) The presence of active metastatic solid cancer or relapsed hematologic malignancy is graded as a major comorbidity, with a likelihood that survival will be less than 5 years; (b) Severe limitation in physical functioning (3 or 4 on the Eastern Cooperative Oncology Group performance status (ECOG‐PS) would define an advanced cancer patient as having a severe comorbidity, with a likelihood of less than 1 year survival. Cancer may be the “Emperor of all Maladies,” but it is no longer a certain death sentence. url: https://www.ncbi.nlm.nih.gov/pubmed/32744382/ doi: 10.1634/theoncologist.2020-0442 id: cord-293285-w8c3ma8l author: Lanza, F title: Reflection on passive immunotherapy in those who need most: some novel strategic arguments for obtaining safer therapeutic plasma or autologous antibodies from recovered COVID ‐19 infected patients date: 2020-05-14 words: 1503.0 sentences: 68.0 pages: flesch: 40.0 cache: ./cache/cord-293285-w8c3ma8l.txt txt: ./txt/cord-293285-w8c3ma8l.txt summary: title: Reflection on passive immunotherapy in those who need most: some novel strategic arguments for obtaining safer therapeutic plasma or autologous antibodies from recovered COVID ‐19 infected patients In this mini-report we propose three potential additional options as the source of such autologous Ab and provide some operational arguments, on evidence based to support implementation such strategic approaches urgently for those in need to save lives: a] the use of hyperimmune immunoglobulin concentrates, which derives from plasma of physiologically immunized donors. However, in western countries the use of convalescent plasma and related strategies may become a reality provided that our hospitals will recommend obtaining an informed consent from recovered COVID-infected patients in order to collect and store their FFP and their derived bioproducts. Use of convalescent whole blood or plasma collected from patients recovered from Ebola virus disease for transfusion, as an empirical treatment during outbreaks abstract: COVID‐19 pandemic is an emerging new human disease, where no vaccines, or monoclonal antibodies (mAbs), or drugs are currently available for therapy. Active vaccination requires the induction of an immune response against a given agent to a susceptible individual for the purpose of preventing or treating an infectious disease and this usually takes time to develop. Thus, the use of existing autologous Ab administration, obtainable from recovered COVID 19 patients, after 2 weeks recovery, is the best and the most practical strategy for providing immediate passive immunity to susceptible recipients in need. url: https://www.ncbi.nlm.nih.gov/pubmed/32407543/ doi: 10.1111/bjh.16814 id: cord-290836-jldfrec9 author: Laosa, Olga title: Rapid assessment at hospital admission of mortality risk from COVID-19: the role of functional status date: 2020-10-08 words: 1857.0 sentences: 120.0 pages: flesch: 55.0 cache: ./cache/cord-290836-jldfrec9.txt txt: ./txt/cord-290836-jldfrec9.txt summary: Objective To evaluate the role of functional status along with other used clinical factors on the occurrence of death in patients hospitalized with COVID-19. Estimated model coefficients served to calculate the expected probability of death for a selected combination of five variables: Barthel, sex, age, comorbidities and severity index (qSOFA). Evidence is even smaller regarding the joint 47 Therefore, the aim of this study was to evaluate, in patients hospitalized with COVID50 19, the role of limitations in activities of daily living along with other habitual clinical 51 factors on death during hospitalization, building a predictive model. Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study abstract: Objective To evaluate the role of functional status along with other used clinical factors on the occurrence of death in patients hospitalized with COVID-19. Design Prospective Cohort study Setting Public University Hospital (Madrid) Participants and methods 375 consecutive patients with COVID-19 infection, admitted to a Public University Hospital (Madrid) between March 1 and March 31, 2020, were included in the Prospective Cohort study. Death was the main outcome. The main variable was disability in Activities of Daily Living (ADL) assessed with the Barthel index. Covariates included sex, age, severity index (Quick Sequential Organ Failure Assessment, qSOFA), polypharmacy (>5 drugs in the month before admission), and comorbidity (≥3 diseases). Multivariable logistic regression was used to identify risk factors for adverse outcomes. Estimated model coefficients served to calculate the expected probability of death for a selected combination of five variables: Barthel, sex, age, comorbidities and severity index (qSOFA). Results Mean age was 66 years (SD 15.33), 207 (55%) males. 74 patients died (19.8%). Mortality was associated to low Barthel index (OR per 5-point decrease 1.11; 95CI 1.03-1.20), male sex (0.23, 0.11-0.47), age (1.07, 1.03-1.10) and comorbidity (2.15; 1.08-4.30) but not to qSOFA (1.29, 0.87-1.93) or polypharmacy (1.54; 0.77-3.08). Calculated mortality risk ranged from 0 to 0.78. Conclusions and implications Functional status predicts death in hospitalized COVID-19 patients. Combination of five variables allows to predict individual probability of death. These findings provide useful information for the decision-making process and management of patients. url: https://www.sciencedirect.com/science/article/pii/S1525861020308471?v=s5 doi: 10.1016/j.jamda.2020.10.002 id: cord-329877-vish6v8e author: Lapinsky, Stephen E. title: ICU management of severe acute respiratory syndrome date: 2003-05-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Severe acute respiratory syndrome (SARS) is a contagious viral illness first recognized in late 2002. It has now been documented in 26 countries worldwide, with significant outbreaks in China, Hong Kong, Singapore, and Toronto. Research into identifying the etiological agent, evaluating modes of disease transmission, and treatment options is currently ongoing. DISCUSSION: The disease can produce a severe bilateral pneumonia, with progressive hypoxemia. Up to 20% of patients require mechanical ventilatory support, with a fatal outcome occurring in about 5% of cases. CONCLUSIONS: We review the current knowledge about this disease, with particular emphasis on ICU management and infection control precautions to prevent disease transmission. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available if you access this article at http://dx.doi.org/10.1007/s00134-003-1821-0. On that page (frame on the left side) a link takes you directly to the supplementary material. url: https://doi.org/10.1007/s00134-003-1821-0 doi: 10.1007/s00134-003-1821-0 id: cord-340542-jz7ca041 author: Lara Álvarez, Miguel Ángel title: Covid-19 mortality in cancer patients in a Madrid hospital during the first 3 weeks of the epidemic date: 2020-08-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Background and objective The Covid-19 pandemic especially affects cancer patients with higher incidence and mortality according to published series of original pandemic foci. The study aims to determine the mortality in our center due to covid-19 in cancer patients during the first 3 weeks of the epidemic. Material and methods The cancer patients who died of covid-19 during the analysis period have been reviewed describing the oncological and the covid-19 infection characteristics and the treatments established. Results Confirmed cases covid-19: 1069 with 132 deaths (12.3%). With cancer 36 patients (3.4%), 15 deceased (41.6%). Of the deceased, only 6 patients (40%) were in active treatment. The most frequent associated tumor was lung (8/15 patients, 53.3%), 11 with metastatic disease (11/15, 73.3%). No specific treatment was established in 40 % (6/15) of the patients. The rest of them received treatments with the active protocols. Conclusion Covid-19 mortality in cancer patients is almost four times higher than that of the general population. Until we have effective treatments or an effective vaccine, the only possibility to protect our patients is to prevent the infection with the appropriate measures. url: https://doi.org/10.1016/j.medcle.2020.05.012 doi: 10.1016/j.medcle.2020.05.012 id: cord-341359-c34gyuv6 author: Larson, Derek T title: Clinical Outcomes of Coronavirus Disease 2019 With Evidence-based Supportive Care date: 2020-05-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Calls for adherence to evidence-based medicine have emerged during the initial wave of the COVID-19 pandemic but reports of outcomes are lacking. This retrospective study of an institutional cohort including 135 patients with confirmed COVID-19 demonstrates positive outcomes when organizational standards of care consist of evidence-based supportive therapies. url: https://www.ncbi.nlm.nih.gov/pubmed/32472675/ doi: 10.1093/cid/ciaa678 id: cord-326017-qw4qynqv author: Laskar, Partha title: “Tomorrow Never Dies”: Recent Advances in Diagnosis, Treatment, and Prevention Modalities against Coronavirus (COVID-19) amid Controversies date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The outbreak of novel coronavirus disease (2019-nCoV or COVID-19) is responsible for severe health emergency throughout the world. The attack of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found to be responsible for COVID-19. The World Health Organization has declared the ongoing global public health emergency as a pandemic. The whole world fights against this invincible enemy in various capacities to restore economy, lifestyle, and safe life. Enormous amount of scientific research work(s), administrative strategies, and economic measurements are in place to create a successful step against COVID-19. Furthermore, differences in opinion, facts, and implementation methods laid additional layers of complexities in this battle against survival. Thus, a timely overview of the recent, important, and overall inclusive developments against this pandemic is a pressing need for better understanding and dealing with COVID-19. In this review, we have systematically summarized the epidemiological studies, clinical features, biological properties, diagnostic methods, treatment modalities, and preventive measurements related to COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32781617/ doi: 10.3390/diseases8030030 id: cord-312614-63qzissw author: Latham, Stephen R. title: Avoiding Ineffective End‐of‐Life Care: A Lesson from Triage? date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Ethicists and physicians all over the world have been working on triage protocols to plan for the possibility that the Covid‐19 pandemic will result in shortages of intensive care unit beds, ventilators, blood products, or medications. In reflecting on those protocols, many health care workers have noticed that, outside the pandemic shortage situation, we routinely supply patients in the ICU with invasive and painful care that will not help the patients survive even their hospitalization. This is the kind of pointless care that even the most basic protocol would triage against. Perhaps this widespread reflection on triage standards will draw our attention to our ongoing custom of supplying burdensome and inefficacious care to those near the end of life—care that most health care providers would not want for themselves. This essay argues that reflecting on triage could help us improve end‐of‐life care. url: https://www.ncbi.nlm.nih.gov/pubmed/32596902/ doi: 10.1002/hast.1141 id: cord-301146-no9pw4gn author: Lattenist, R. title: COVID-19 in Adult Patients with Hematological Disease: Analysis of Clinical Characteristics and Outcomes date: 2020-07-07 words: 867.0 sentences: 57.0 pages: flesch: 52.0 cache: ./cache/cord-301146-no9pw4gn.txt txt: ./txt/cord-301146-no9pw4gn.txt summary: authors: Lattenist, R.; Yildiz, H.; De Greef, J.; Bailly, S.; Yombi, J.C. title: COVID-19 in Adult Patients with Hematological Disease: Analysis of Clinical Characteristics and Outcomes However, data on patients with COVID-19 and an underlying hematological disease as well as on specific risks factors in this particularly immunocompromised population are scarce [2] [3] [4] [5] . The association between lower hemoglobin level at presentation and a higher mortality rate was also found by Mehta et al. In our small cohort of patients, we found no association between the myeloid/lymphoid character of the underlying disease and COVID-19 fatality (data not shown) but, to mention, our series did not include any MPN or MDS except under the form of a progression to secondary acute myeloid leukemia. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study abstract: nan url: https://doi.org/10.1007/s12288-020-01318-4 doi: 10.1007/s12288-020-01318-4 id: cord-283779-mudwcypl author: Lauretani, Fulvio title: Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications date: 2020-05-11 words: 9727.0 sentences: 500.0 pages: flesch: 42.0 cache: ./cache/cord-283779-mudwcypl.txt txt: ./txt/cord-283779-mudwcypl.txt summary: The chronic increase in inflammatory cytokines, augmented by COVID-19 infection, may explain the higher tendency for "the cascade leading to pulmonary fibrosis and insufficiency and activation of clotting" and poorer clinical prognosis, especially in multimorbid older persons (4) . In case of persistent fever, higher than 37.5°C for a time longer than 3 days and peripheral oxygen level lower than 95% after starting therapy, we should consider and proceed to hospitalization especially in multimorbid older patients with cardiac, respiratory diseases and diabetes. First, patients at risk for poor outcomes and higher mortality following infection with SARS-CoV-2, namely older adults and multimorbid individuals, should be checked for malnutrition through screening and assessment. Older patients infected by COVID-19 often experience atypical and less severe symptoms in older persons, side-effects of the drugs and require specific nutritional and motor treatment for avoiding disability and death. abstract: Covid-19 infection is a multisystem disease more frequent in older individuals, especially in those with multiple chronic diseases. This multimorbid and frail population requires attention and a personalized comprehensive assessment in order to avoid the occurrence of adverse outcomes. As other diseases, the COVID-19 presentation in older patients is often atypical with less severe and unspecific symptoms. These subjects both at home and during hospitalization suffer isolation and the lack of support of caregivers. The geriatric care in COVID-19 wards is often missing. The application of additional instruments would be necessary to facilitate and personalize the clinical approach, not only based on diseases but also on functional status. This narrative review starts from diagnostic evaluation, continues with adapted pharmacologic treatment and ends with the recovery phase targeting the nutrition and physical exercise. We developed a check-list of respiratory, gastro-intestinal and other less-specific symptoms, summarized in a table and easily to be filled-up by patients, nurses and general practitioners. As second step, we reported the clinical phases of this disease. Far to be considered just viral infective and respiratory, this disease is also an inflammatory and thrombotic condition with frequent bacterial over-infection. We finally considered timing and selection of treatment, which depend on the disease phase, co-administration of other drugs and require the monitoring of renal, liver and cardiac function. This underlines the role of age not just as a limitation, but also an opportunity to increase the quality and the appropriateness of multidisciplinary and multidimensional intervention in this population. (www.actabiomedica.it) url: https://www.ncbi.nlm.nih.gov/pubmed/32420939/ doi: 10.23750/abm.v91i2.9629 id: cord-017946-fa4ehlb0 author: Lawless, Ryan A. title: Adjuncts to Resuscitation date: 2018-05-26 words: 5937.0 sentences: 298.0 pages: flesch: 36.0 cache: ./cache/cord-017946-fa4ehlb0.txt txt: ./txt/cord-017946-fa4ehlb0.txt summary: This chapter will focus on adjuncts to damage control resuscitation (DCR) including massive transfusion protocols, the "other" tenets of damage control resuscitation, hypertonic saline, tranexamic acid, pharmacologic resuscitation, Factor VIIa, and prothrombin complex, and viscoelastic testing. Looking at the incorporation of the other two principles (permissive hypotension and minimizing crystalloids) into a mature trauma center already incorporating a transfusion strategy approaching whole blood, investigators found an improvement in survival among emergent laparotomy patients [4] . The authors noted a significantly improved mortality compared to that predicted by the Trauma Related Injury Severity Score (TRISS) in patients who received fibrinogen concentrate during their initial resuscitation. Animal models of liver injury associated hemorrhagic shock have shown decreased blood loss, increased mean arterial pressure, and significantly higher hemoglobin levels with vasopressin administration compared to standard crystalloid resuscitation [74] . A randomized, placebo-controlled study (AVERT Shock) is currently underway to investigate the potential benefit of vasopressin administration during the early resuscitation of bleeding trauma patients [79]. abstract: Damage control resuscitation has been increasingly adopted and practiced over the last decade. The concepts used are not new to this era of medicine but are novel in combination. This chapter will focus on adjuncts to damage control resuscitation (DCR) including massive transfusion protocols, the “other” tenets of damage control resuscitation, hypertonic saline, tranexamic acid, pharmacologic resuscitation, Factor VIIa, and prothrombin complex, and viscoelastic testing. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122643/ doi: 10.1007/978-3-319-72607-6_20 id: cord-304418-k9owyolj author: Le Maréchal, M. title: COVID-19 in clinical practice: a narrative synthesis date: 2020-09-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 (COVID-19) was first reported in the city of Wuhan, China. The disease rapidly spread to the rest of China, to Southern-East Asia, then to Europe, America, and on to the rest of the world. COVID-19 is associated with a betacoronavirus named SARS-CoV-2. The virus penetrates the organism through the respiratory tract, conveyed by contaminated droplets. The main cell receptor targeted is the surface-bound ACE-2. As of the 26th July 2020, 15,200,000 COVID-19 cases and 650,000 deaths were reported worldwide. The mortality rate is estimated between 1.3 and 18.3%. The reproductive rate without any public health intervention is estimated around 4-5.1 in France. Most hospitalized patients for COVID-19 present respiratory symptoms, which in some cases is associated with fever. Up to 86% of admissions to ICU are related to acute respiratory failure. To date, no anti-viral therapy has proven its efficacy considering randomized trials. Only immunomodulatory treatments such as corticosteroids have shown to cause significant improvement in patient outcome. url: https://www.ncbi.nlm.nih.gov/pubmed/33007400/ doi: 10.1016/j.medmal.2020.09.012 id: cord-258117-5gpo8smn author: Le Naour, Julie title: Trial watch: IDO inhibitors in cancer therapy date: 2020-06-14 words: 8522.0 sentences: 471.0 pages: flesch: 34.0 cache: ./cache/cord-258117-5gpo8smn.txt txt: ./txt/cord-258117-5gpo8smn.txt summary: 10, 58, 59 In this setting, preclinical studies have revealed an interesting paradox: while IDO inhibitors have a negligible effect on established tumors as single-agent, combination of IDO inhibitors and immunotherapies including checkpoint blockers targeting cytotoxic T lymphocyte-associated protein 4 (CTLA4) or PD-1 yields a synergistic effect to control cancer burden and favor survival. 142 These disappointing results suggested that this combinatorial therapy did not improve the clinical outcome of melanoma patients receiving pembrolizumab, confirming that the role of epacadostat (or IDO1 inhibitors in general) in advanced solid tumors with robust PD-1 signaling remains unclear. [210] [211] [212] Along similar lines, the Phase III study NCT03661320 compared the efficacy, tolerability and safety of three therapeutic regimens for MIBC: neoadjuvant standard of care chemotherapy with cisplatin [213] [214] [215] [216] [217] and gemcitabine, 218,219 (NAC) versus NAC combined with nivolumab or nivolumab plus BMS-986205, followed by continuation of adjuvant immunotherapy (nivolumab with or without the IDO1 inhibitor) post radical cystectomy. abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first, rate-limiting step of the so-called “kynurenine pathway”, which converts the essential amino acid L-tryptophan (Trp) into the immunosuppressive metabolite L-kynurenine (Kyn). While expressed constitutively by some tissues, IDO1 can also be induced in specific subsets of antigen-presenting cells that ultimately favor the establishment of immune tolerance to tumor antigens. At least in part, the immunomodulatory functions of IDO1 can be explained by depletion of Trp and accumulation of Kyn and its derivatives. In animal tumor models, genetic or pharmacological IDO1 inhibition can cause the (re)activation of anticancer immune responses. Similarly, neoplasms expressing high levels of IDO1 may elude anticancer immunosurveillance. Therefore, IDO1 inhibitors represent promising therapeutic candidates for cancer therapy, and some of them have already entered clinical evaluation. Here, we summarize preclinical and clinical studies testing IDO1-targeting interventions for oncologic indications. url: https://www.ncbi.nlm.nih.gov/pubmed/32934882/ doi: 10.1080/2162402x.2020.1777625 id: cord-301832-6czrdmzb author: Leber, Danielle title: PC-FACS September 1, 2020 date: 2020-09-06 words: 2363.0 sentences: 156.0 pages: flesch: 49.0 cache: ./cache/cord-301832-6czrdmzb.txt txt: ./txt/cord-301832-6czrdmzb.txt summary: This single-site prospective longitudinal study (1998) (1999) (2000) (2001) (2002) (2003) (2004) (2005) (2006) (2007) (2008) (2009) (2010) (2011) (2012) (2013) (2014) (2015) (2016) among nondisabled community-living persons age ≥70 years evaluated risk factors and intervening illnesses and injuries (ie, events) associated with reduced recovery after episodes of progressive and catastrophic SD. To access this article, link to PubMed. Background: Clinical effectiveness is defined as the application of the best knowledge (from research, clinical experience, and patient preferences), to achieve optimum processes and care outcomes. This study evaluated care effectiveness in an Ireland SPCU, including an analysis of the temporal relationship among unit admission, patients'' phase of illness, and different aspects of patient and family distress. To access this article, link to PubMed. Background: Studies evaluating the effects of pre-existing mental health disorders (MHDs) on patients diagnosed with lung cancer universally find mental illness to be associated with increased mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32898591/ doi: 10.1016/j.jpainsymman.2020.09.003 id: cord-309207-n8u8ddv7 author: Lechien, Jerome R. title: Loss of Smell and Taste in 2013 European Patients With Mild to Moderate COVID-19 date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32449883/ doi: 10.7326/m20-2428 id: cord-333698-e73d9lbu author: Lechien, Jerome R. title: Features of Mild-to-Moderate COVID-19 Patients with Dysphonia. date: 2020-06-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: To explore the prevalence of dysphonia in European patients with mild-to-moderate COVID-19 and the clinical features of dysphonic patients. METHODS: The clinical and epidemiological data of 702 patients with mild-to-moderate COVID-19 were collected from 19 European Hospitals. The following data were extracted: age, sex, ethnicity, tobacco consumption, comorbidities, general and otolaryngological symptoms. Dysphonia and otolaryngological symptoms were self-assessed through a 4-point scale. The prevalence of dysphonia, as part of the COVID-19 symptoms, was assessed. The outcomes were compared between dysphonic and non-dysphonic patients. The association between dysphonia severity and outcomes was studied through Bayesian analysis. RESULTS: A total of 188 patients were dysphonic, accounting for 26.8% of cases. Females developed more frequently dysphonia than males (p=0.022). The proportion of smokers was significantly higher in the dysphonic group (p=0.042). The prevalence of the following symptoms was higher in dysphonic patients compared with non-dysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea and vomiting. The severity of dyspnea, dysphagia, ear pain, face pain, throat pain and nasal obstruction was higher in dysphonic group compared with non-dysphonic group. There were significant associations between the severity of dysphonia, dysphagia and cough. CONCLUSION: Dysphonia may be encountered in a quarter of patients with mild-to-moderate COVID-19 and should be considered as a symptom list of the infection. Dysphonic COVID-19 patients are more symptomatic than non-dysphonic individuals. Future studies are needed to investigate the relevance of dysphonia in the COVID-19 clinical presentation. url: https://www.sciencedirect.com/science/article/pii/S0892199720301831?v=s5 doi: 10.1016/j.jvoice.2020.05.012 id: cord-011483-zc6ve6le author: Leclerc, Angela M. title: Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients date: 2020-05-20 words: 5727.0 sentences: 260.0 pages: flesch: 41.0 cache: ./cache/cord-011483-zc6ve6le.txt txt: ./txt/cord-011483-zc6ve6le.txt summary: Neurostimulant administration data were extracted from the electronic medication administration record, including medication (amantadine, modafinil, or both), starting dose, time from stroke to initiation, and whether the neurostimulant was continued at hospital discharge. Amantadine and modafinil are administered to patients following acute stroke in our intensive care unit (ICU) on an ad hoc basis, but data supporting this practice are largely limited to delayed treatment in rehabilitation or outpatient facilities with very few reports during the acute care hospitalization [17] [18] [19] . Two hundred five patients received amantadine and/ or modafinil during the 3.7 year study period and 118 patients were initially excluded: neurostimulant administered for an indication other than acute stroke (TBI [n = 50], cardiac arrest [n = 15], brain tumor [n = 6], encephalitis [n = 5], or encephalopathy [n = 4]); neurostimulant prescribed prior to hospital admission (n = 27) or administered for < 72 h (n = 8); or history of seizures (n = 3). abstract: BACKGROUND/OBJECTIVE: Neurostimulants may improve or accelerate cognitive and functional recovery after intracerebral hemorrhage (ICH), ischemic stroke (IS), or subarachnoid hemorrhage (SAH), but few studies have described their safety and effectiveness in the intensive care unit (ICU). The objective of this study was to describe amantadine and modafinil administration practices during acute stroke care starting in the ICU and to evaluate safety and effectiveness. METHODS: Consecutive adult ICU patients treated with amantadine and/or modafinil following acute non-traumatic IS, ICH, or SAH were evaluated. Neurostimulant administration data were extracted from the electronic medication administration record, including medication (amantadine, modafinil, or both), starting dose, time from stroke to initiation, and whether the neurostimulant was continued at hospital discharge. Patients were considered responders if they met two of three criteria within 9 days of neurostimulant initiation: increase in Glasgow coma scale (GCS) score ≥ 3 points from pre-treatment baseline, improved wakefulness or participation documented in caregiver notes, or clinical improvement documented in physical or occupational therapy notes. Potential confounders of the effectiveness assessment and adverse drug effects were also recorded. RESULTS: A total of 87 patients were evaluable during the 3.7-year study period, including 41 (47%) with ICH, 29 (33%) with IS, and 17 (20%) with SAH. The initial neurostimulant administered was amantadine in 71 (82%) patients, modafinil in 13 (15%), or both in 3 (3%) patients. Neurostimulants were initiated a median of 7 (4.25, 12.75) days post-stroke (range 1–27 days) for somnolence (77%), not following commands (32%), lack of eye opening (28%), or low GCS (17%). The most common starting dose was 100 mg twice daily for both amantadine (86%) and modafinil (54%). Of the 79 patients included in the effectiveness evaluation, 42 (53%) were considered responders, including 34/62 (55%) receiving amantadine monotherapy and 8/24 (33%) receiving both amantadine and modafinil at the time they met the definition of a responder. No patient receiving modafinil monotherapy was considered a responder. The median time from initiation to response was 3 (2, 5) days. Responders were more frequently discharged home or to acute rehabilitation compared to non-responders (90% vs 62%, p = 0.006). Among survivors, 63/72 (88%) were prescribed a neurostimulant at hospital discharge. The most common potential adverse drug effect was sleep disruption (16%). CONCLUSIONS: Neurostimulant administration during acute stroke care may improve wakefulness. Future controlled studies with a neurostimulant administration protocol, prospective evaluation, and discretely defined response and safety criteria are needed to confirm these encouraging findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12028-020-00986-4) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239352/ doi: 10.1007/s12028-020-00986-4 id: cord-336258-dxps48bo author: Lee, Anne W.M. title: Advocacy to provide good quality oncology services during the COVID-19 pandemic – Actions at 3-Levels date: 2020-05-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic is a devastating catastrophe to the whole world, China is the first country seriously affected. This review shows that it is possible to stop wide-spread infection in the country and to provide good quality oncology services even during this challenging period, through concerted efforts with well-organized actions at all levels (National/Municipal, Hospital and Department). The key strategies leading to successful impacts are summarized for sharing. In addition to making practice changes to cope with the adverse realities, oncologists should also work together to raise pragmatic suggestions to policy makers and be strong advocates to protect our patients from the detrimental effect of delay or compromised treatment. url: https://api.elsevier.com/content/article/pii/S0167814020302127 doi: 10.1016/j.radonc.2020.04.031 id: cord-337120-irpm5g7g author: Lee, Bruce Y. title: The Role of Internists During Epidemics, Outbreaks, and Bioterrorist Attacks date: 2007-01-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Internists are well-positioned to play significant roles in recognizing and responding to epidemics, outbreaks, and bioterrorist attacks. They see large numbers of patients with various health problems and may be the patients’ only interaction with the medical community for symptoms resulting from infectious diseases and injuries from radiation, chemicals, and/or burns. Therefore, Internists must understand early warning signs of different bioterrorist and infectious agents, proper reporting channels and measures, various ways that they can assist the public health response, and roles of different local, state, and federal agencies. In addition, it is important to understand effects of a public health disaster on clinic operations and relevant legal consequences. url: https://www.ncbi.nlm.nih.gov/pubmed/17351853/ doi: 10.1007/s11606-006-0030-2 id: cord-018590-rkp89dqo author: Lee, Chu Keong title: Narratives in Healthcare date: 2010-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In this chapter, the narrative is defined and the elements of the narrative are elucidated. Three lenses through which one can view the role of narratives in healthcare are discussed. First, organizational narratives help to foster social capital in the organization and, therefore, contribute to the people aspect of the knowledge management initiative in the organization. Second, the recuperative and relationship building roles of illness narratives are described. Third, narratives from the practice of narrative medicine are explored. The chapter concludes by proposing four requirements for narratives to be effective, namely, effective listening skills, the availability of time and place for storytelling, and the codification of narratives. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123505/ doi: 10.1007/978-0-387-49009-0_10 id: cord-351129-lzzyn570 author: Lee, Jae-Hyun title: Management of Allergic Patients During the COVID-19 Pandemic in Asia date: 2020-06-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Although a viral infection is a major triggering factor of asthma and allergic diseases, asthma is suggested to be not a predisposing condition for coronavirus disease 2019 (COVID-19) infection. However, patients with severe asthma/allergic disease requiring systemic corticosteroids or immunosuppressive agents may be at higher risk of more severe clinical course of this infectious disease. For allergic patients who have been followed up at an allergy clinic in our region, it is recommended that they (patients with asthma, rhinitis, atopic dermatitis or chronic urticaria) continue to receive maintenance therapy and be in a well-controlled status. Patients who have used biologics (currently available for targeting type 2 inflammation) and allergen immunotherapy should continue the treatment while minimizing hospital and face-to-face visits. It is essential to wear protective equipment for the protection of health care workers as well as patients. We report this consensus to support allergists and clinical immunologists to make optimal decisions under the urgent situation in Asia. url: https://doi.org/10.4168/aair.2020.12.5.783 doi: 10.4168/aair.2020.12.5.783 id: cord-269099-q5nyzlhs author: Lee, Jisun title: Exploring the spatial arrangement of patient rooms for minimum nurse travel in hospital nursing units in Korea date: 2020-07-23 words: 7532.0 sentences: 357.0 pages: flesch: 55.0 cache: ./cache/cord-269099-q5nyzlhs.txt txt: ./txt/cord-269099-q5nyzlhs.txt summary: The agent-based simulation was conducted to model nurses'' walking trails, and the distance of one nurse travel to assigned patient rooms was measured for each nurse. The agent-based simulation was conducted to model nurses'' walking trails, and the distance of one nurse travel to assigned patient rooms was measured for each nurse. With revisions in the spatial arrangement of patient rooms, locating multibed rooms near the nurse station, symmetric room layout centering the nurse station, and planning both single/double-bed and multi-bed rooms on one side of corridors, nurse travel distance decreased more than 15%. In the racetrack type units where single/double-bed and multi-bed rooms are located on the opposite sides of the floor (with the service core in the middle), nurses have to travel along both sides to care assigned patients. Among Korean inpatient unit case studies, Shin and Kang (2016) assessed nurse walking distances using traditional point-to-point linear measurement based on field interviews of nurses'' patient room assignments. abstract: Abstract With increasing demands on medical care services, one of the trends is the mixed patient room arrangement of single/double-bed and multi-bed rooms in a nursing unit on the same floor. This influences nurse-to-patient assignment and often causes an unbalanced workload and longer travel distances for nurses. The objective of this study was to investigate how floor configuration and room density influence nurse travel in the hospital's medical surgical units in Korea. This study presented a novel approach to measure nurse travel distances in eight existing nursing units. The agent-based simulation was conducted to model nurses' walking trails, and the distance of one nurse travel to assigned patient rooms was measured for each nurse. With revisions in the spatial arrangement of patient rooms, locating multi-bed rooms near the nurse station, symmetric room layout centering the nurse station, and planning both single/double-bed and multi-bed rooms on one side of corridors, nurse travel distance decreased more than 15%. This study contributed to the knowledge of agent-based simulation as an evaluation framework for spatial analysis. Apart from application to Korea, these results are particularly of interest in countries where private patient rooms are not commonly economically feasible. url: https://www.sciencedirect.com/science/article/pii/S2095263520300480 doi: 10.1016/j.foar.2020.06.003 id: cord-296018-lgx5k2kp author: Lee, Jong-Bin title: Evaluation of prognosis related to compliance with supportive periodontal treatment in patients with chronic periodontitis: a clinical retrospective study date: 2019-04-17 words: 5374.0 sentences: 246.0 pages: flesch: 48.0 cache: ./cache/cord-296018-lgx5k2kp.txt txt: ./txt/cord-296018-lgx5k2kp.txt summary: title: Evaluation of prognosis related to compliance with supportive periodontal treatment in patients with chronic periodontitis: a clinical retrospective study Additionally, the number of newly decayed and extracted teeth and changes in alveolar bone levels around the teeth and implants were significant prognostic factors related to PC-SPT. In addition, the majority of studies mainly focused on classifying patients based on previous dental treatments and on conducting comparisons based on clinical indices in periodontal tissues without considering the SPT period [13] [14] [15] . Using patients'' clinical and radiographic records, the number of newly decayed teeth, alveolar bone level changes around the teeth and implants, the number of newly extracted teeth, https://doi.org/10.5051/jpis.2019.49.2.76 Importance of supportive periodontal treatment https://jpis.org and implant removal during SPT were examined. The effect of PC-SPT on treatment prognosis was evaluated by studying its relationship with the number of newly decayed and extracted teeth and the direction of alveolar bone change around teeth and implants. abstract: PURPOSE: The purpose of this study was to evaluate the prognostic effect of patient compliance with supportive periodontal treatment (PC-SPT). Chronic periodontitis patients were classified based on their compliance level, and factors affecting PC-SPT and the prognosis of PC-SPT were investigated. METHODS: This study selected 206 patients who started SPT after receiving periodontal treatment between 2010 and 2012. Patients who continued SPT through February 2016 were included. The patients were classified according to whether they exhibited complete compliance (100% of visits), excellent compliance (≥70% of visits), incomplete compliance (<70% of visits), or non-compliance (only 2 visits). Patient characteristics that could affect PC-SPT, such as age, sex, distance of the clinic from their residence, implantation, and periodontal treatment, were investigated. The number of newly decayed and extracted teeth, alveolar bone level changes around the teeth and implants, and implant removal were examined to evaluate the prognosis of PC-SPT. RESULTS: Sex and the presence of an implant significantly affected PC-SPT. Additionally, the number of newly decayed and extracted teeth and changes in alveolar bone levels around the teeth and implants were significant prognostic factors related to PC-SPT. CONCLUSIONS: PC-SPT in chronic periodontitis patients will help maintain periodontal health and prevent further periodontal disease. url: https://www.ncbi.nlm.nih.gov/pubmed/31098329/ doi: 10.5051/jpis.2019.49.2.76 id: cord-287742-y1j9x5ne author: Lee, Kai Wei title: Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis date: 2020-10-06 words: 6545.0 sentences: 292.0 pages: flesch: 45.0 cache: ./cache/cord-287742-y1j9x5ne.txt txt: ./txt/cord-287742-y1j9x5ne.txt summary: Therefore, we performed a systematic review and meta-analysis of currently available epidemiological, clinical, and laboratory data related to both stroke and COVID-19 infection. We, therefore, performed a systematic review and metaanalysis involving the epidemiological, clinical presentation, imaging characteristics, and laboratory finding related to both stroke and COVID-19 infection. The following data were extracted from every study: the last name of the first author, year of publication, country, severity status, study design, patient characteristics (ethnicity composition, gender, and mean age), comorbidities (diabetes, hyperlipidemia, hypertension, ischemic heart disease, heart failure, previous stroke, chronic kidney disease/end-stage renal disease, number of stroke patients per overall participants, any information relevant to strokes such as the location of stroke [arterial or venous]), types of stroke (ischemic or haemorrhagic), classification of stroke, mortality rate, and blood parameters. The aim of this current study is to perform a systematic review and meta-analysis concerning the epidemiological, clinical presentation, imaging characteristics, and laboratory findings related to both stroke and COVID-19 infection. abstract: Background: As the world witnessed the devastation caused by the coronavirus disease 2019 (COVID-19) outbreak, a growing body of literature on COVID-19 is also becoming increasingly available. Stroke has increasingly been reported as a complication of COVID-19 infection. However, a systematic synthesis of the available data has not been conducted. Therefore, we performed a systematic review and meta-analysis of currently available epidemiological, clinical, and laboratory data related to both stroke and COVID-19 infection. Methods: We systematically searched Medline, Cinahl, and PubMed for studies related to stroke and COVID-19 from inception up to June 4, 2020. We selected cohort studies, case series, and case reports that reported the occurrence of stroke in COVID-19 patients. A fixed-effects model was used to estimate the pooled frequency of stroke in COVID-19 patients with a 95% confidence interval (CI). Results: Twenty-eight studies were included in the systematic review and seven studies for the meta-analysis. The pooled frequency of stroke in COVID-19 patients was 1.1% (95% CI: 0.8, 1.3). The heterogeneity was low (I(2) = 0.0%). Even though the frequency of stroke among patients having COVID-19 infection was low, those with concomitant COVID-19 infection and stroke suffered from a more severe infection and eventually had a poorer prognosis with a higher mortality rate (46.7%) than COVID-19 alone. Many COVID-19 patients shared the common traditional risk factors for stroke. We noted that ischemic stroke involving the anterior circulation with large vessels occlusion is the most common type of stroke with more strokes seen in multi-territorial regions, suggesting systemic thromboembolism. An elevated level of D-dimers, C-reactive protein, ferritin, lactic acid dehydrogenase, troponin, ESR, fibrinogen, and a positive antiphospholipid antibody were also noted in this review. Conclusions: The occurrence of stroke in patients with COVID-19 infection is uncommon, but it may pose as an important prognostic marker and indicator of severity of infection, by causing large vessels occlusion and exhibiting a thrombo-inflammatory vascular picture. Physicians should be made aware and remain vigilant on the possible two-way relationship between stroke and COVID-19 infection. The rate of stroke among patients with COVID-19 infection may increase in the future as they share the common risk factors. url: https://doi.org/10.3389/fneur.2020.579070 doi: 10.3389/fneur.2020.579070 id: cord-333183-xyuj1j57 author: Lee, Lennard Y W title: COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study date: 2020-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Individuals with cancer, particularly those who are receiving systemic anticancer treatments, have been postulated to be at increased risk of mortality from COVID-19. This conjecture has considerable effect on the treatment of patients with cancer and data from large, multicentre studies to support this assumption are scarce because of the contingencies of the pandemic. We aimed to describe the clinical and demographic characteristics and COVID-19 outcomes in patients with cancer. METHODS: In this prospective observational study, all patients with active cancer and presenting to our network of cancer centres were eligible for enrolment into the UK Coronavirus Cancer Monitoring Project (UKCCMP). The UKCCMP is the first COVID-19 clinical registry that enables near real-time reports to frontline doctors about the effects of COVID-19 on patients with cancer. Eligible patients tested positive for severe acute respiratory syndrome coronavirus 2 on RT-PCR assay from a nose or throat swab. We excluded patients with a radiological or clinical diagnosis of COVID-19, without a positive RT-PCR test. The primary endpoint was all-cause mortality, or discharge from hospital, as assessed by the reporting sites during the patient hospital admission. FINDINGS: From March 18, to April 26, 2020, we analysed 800 patients with a diagnosis of cancer and symptomatic COVID-19. 412 (52%) patients had a mild COVID-19 disease course. 226 (28%) patients died and risk of death was significantly associated with advancing patient age (odds ratio 9·42 [95% CI 6·56–10·02]; p<0·0001), being male (1·67 [1·19–2·34]; p=0·003), and the presence of other comorbidities such as hypertension (1·95 [1·36–2·80]; p<0·001) and cardiovascular disease (2·32 [1·47–3·64]). 281 (35%) patients had received cytotoxic chemotherapy within 4 weeks before testing positive for COVID-19. After adjusting for age, gender, and comorbidities, chemotherapy in the past 4 weeks had no significant effect on mortality from COVID-19 disease, when compared with patients with cancer who had not received recent chemotherapy (1·18 [0·81–1·72]; p=0·380). We found no significant effect on mortality for patients with immunotherapy, hormonal therapy, targeted therapy, radiotherapy use within the past 4 weeks. INTERPRETATION: Mortality from COVID-19 in cancer patients appears to be principally driven by age, gender, and comorbidities. We are not able to identify evidence that cancer patients on cytotoxic chemotherapy or other anticancer treatment are at an increased risk of mortality from COVID-19 disease compared with those not on active treatment. FUNDING: University of Birmingham, University of Oxford. url: https://www.ncbi.nlm.nih.gov/pubmed/32473682/ doi: 10.1016/s0140-6736(20)31173-9 id: cord-343797-kpmz5kwg author: Lee, Martin Beng‐Huat title: GOING TO WAR ON COVID19: MOBILIZING AN ACADEMIC NEPHROLOGY GROUP PRACTICE date: 2020-07-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: AIMS: The COVID‐19 pandemic poses unprecedented operational challenges to nephrology divisions in every country as they cope with COVID‐19‐related kidney disease in addition to regular patient care. Although general approaches have been proposed, there is a lack of practical guidance for nephrology division response in a hospital facing a surge of cases. Here, we describe the specific measures that our division has taken in the hope that our experience in Singapore may be helpful to others METHODS: Descriptive narrative RESULTS: A compilation of operational responses to the COVID‐19 pandemic taken by a nephrology division at a Singapore university hospital CONCLUSION: Nephrology operational readiness for COVID‐19 requires a clinical mindset shift from usual standard of care to a crisis exigency model that targets best outcomes for available resources. Rapid multi‐disciplinary efforts that evolve flexibly with the local dynamics of the outbreak are required. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32621527/ doi: 10.1111/nep.13753 id: cord-326851-0jxdnm1l author: Lee, Sang M. title: Lessons Learned from Battling COVID-19: The Korean Experience date: 2020-10-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: The COVID-19 pandemic has swept the world like a gigantic tsunami, turning social and economic activities upside down. Methods: This paper presents some of the innovative response strategies implemented by the public health system, healthcare facilities, and government in South Korea, which has been hailed as the model country for its success in containing COVID-19. Korea reinvented its public health infrastructure with a sense of urgency. Results: Korea’s success rests on its readiness, with the capacity for massive testing and obtaining prompt test results, effective contact tracing based on its world-leading mobile technologies, timely provision of personal protective equipment (PPE) to first responders, effective treatment of infected patients, and invoking citizens’ community and civic conscience for the shared goal of defeating the pandemic. The lessons learned from Korea’s response in countering the onslaught of COVID-19 provide unique implications for public healthcare administrators and operations management practitioners. Conclusion: Since many epidemic experts warn of a second wave of COVID-19, the lessons learned from the first wave will be a valuable resource for responding to the resurgence of the virus. url: https://doi.org/10.3390/ijerph17207548 doi: 10.3390/ijerph17207548 id: cord-286525-0354438s author: Lee, Todd C. title: Tocilizumab versus the covid19 tempest: all’s well that ends well or much ado about nothing? date: 2020-09-29 words: 1440.0 sentences: 85.0 pages: flesch: 46.0 cache: ./cache/cord-286525-0354438s.txt txt: ./txt/cord-286525-0354438s.txt summary: One of the unexpected findings from this study was an observed lack of benefit from steroids in contrast to the RECOVERY randomized controlled trial results [4] or a recent meta-analysis of steroid trials in critically ill patients. The phase III COVACTA trial (NCT04317092) found tocilizumab did not reduce mortality in hospitalized patients with severe COVID-19 pneumonia [11] . Similarly a large trial of sarilumab (NCT04315298) in severe and critical COVID-19 was stopped by the data safety monitoring board due to lack of benefit and a potential signal for harm in non-ventilated patients [12] and a second international trial (NCT04327388) also failed to meet its primary or key secondary outcomes [13] . Reconciling their results with those from randomized control trials raises important questions about the causal effect of the hyperinflammatory response and its role in the development of severe COVID-19. Sanofi provides update on Kevzara® (sarilumab) Phase 3 trial in severe and critically ill COVID-19 patients outside the abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33007475/ doi: 10.1016/j.cmi.2020.09.033 id: cord-353987-hj94a04i author: Lehmann, L. H. title: Establishing an oncocardiology service date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Oncocardiology is an emerging field in cardiovascular healthcare. Besides establishing surveillance and follow-up strategies for cancer patients, it will be essential to set up specialized oncocardiology services. However, there is a lack of clinical studies to give evidence-based recommendations regarding cardiological diagnostic and therapeutic approaches for cancer patients. An oncocardiology service is a patient-centered structure that aims to integrate research and interdisciplinary patient care to bridge this gap. We discuss the current challenges in developing an oncocardiology service and review the literature on this topic. We further provide an overview of the essential diagnostic tools and upcoming ethical issues to be considered in the management of oncology patients. url: https://doi.org/10.1007/s00059-020-04952-w doi: 10.1007/s00059-020-04952-w id: cord-331533-0toegbv8 author: Leiker, Brenna title: COVID – 19 CASE STUDY IN EMERGENCY MEDICINE PREPAREDNESS AND RESPONSE; FROM PERSONAL PROTECTIVE EQUIPMENT TO DELIVERGY OF CARE date: 2020-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32800348/ doi: 10.1016/j.disamonth.2020.101060 id: cord-005425-0hxow3sj author: Lekakis, L title: Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies date: 2006-08-07 words: 2757.0 sentences: 161.0 pages: flesch: 55.0 cache: ./cache/cord-005425-0hxow3sj.txt txt: ./txt/cord-005425-0hxow3sj.txt summary: title: Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies In order to overcome this barrier, we investigated a strategy by which patients without higher priority donors were to be transplanted with an unrelated CB unit that should contain at least 2 Â 10 7 total nucleated cells (TNCs)/kg of recipient weight. Here, we report the results of a phase II trial that enrolled heavily pretreated patients with high-risk hematologic malignancies that was prematurely interrupted owing to high rates of engraftment failure and excessive mortality. Transplants of umbilical cord blood or bone marrow from unrelated donors in adults with Acute Leukemia Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia Hematopoietic engraftment and survival in adults recipients of umbilical-cord blood from unrelated donors Successful engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with advanced hematological diseases abstract: Cell dose is a critical determinant of outcomes in unrelated cord blood (CB) transplantation. We investigated a strategy in which CB units should contain at least 2 × 10(7) total nucleated cells/kg of recipient weight, otherwise a second unit had to be added. We report the results of a study that was prematurely closed owing to toxicity. Patients with advanced hematologic malignancies without a human leukocyte antigen-matched sibling or unrelated donor were eligible. Conditioning regimen consisted of fludarabine and 12 Gy of total body irradiation (n=11), or melphalan (n=4), with antithymocyte globulin. Graft-versus-host disease prophylaxis was tacrolimus and methotrexate. Fifteen patients with acute leukemia (n=9), chronic myelogenous leukemia (n=2), multiple myeloma (n=2) and lymphoma (n=2) were treated; 60% had relapsed disease at transplantation. Three patients received double CB transplants. The 100-day and 1-year treatment-related mortality rates were 40 and 53%, respectively. Median time to neutrophil and platelet engraftment was 22 days (n=10) and 37 days (n=10), respectively. One patient had secondary graft failure and five patients failed to engraft. Two patients are alive and disease free; 4-year actuarial survival is 33 versus 0% for patients transplanted in remission versus in relapse. We concluded that disease status was the main determinant of treatment failure in this study. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091659/ doi: 10.1038/sj.bmt.1705467 id: cord-269190-w74bjtq1 author: Lennox, Angela M. title: Care of the Geriatric Rabbit date: 2010-02-11 words: 3434.0 sentences: 227.0 pages: flesch: 43.0 cache: ./cache/cord-269190-w74bjtq1.txt txt: ./txt/cord-269190-w74bjtq1.txt summary: This article examines the spectrum of disease that can affect the geriatric rabbit as well as crucial factors concerning the clinical management of the animal up to the end of its life. Though designed for dogs and cats, the author and others have used this product in rabbits with chronic renal failure requiring longer-term at-home subcutaneous administration of fluid (see Hospice and end-oflife issues later in this article) (Fig. 1) . In some cases all teeth are eventually lost, and patients survive with good to excellent quality of life on a diet of liquid Critical Care (Oxbow Animal Health, Murdoch, NE). Causes are varied, and can include chronic renal failure and acquired dental disease. Use is not recommended in humans and tested animal patients that are dehydrated, or have liver or renal disease (due to reduction of blood flow to the kidneys). abstract: The average life span reported in laboratory and lay literature for the domestic rabbit is 5 to 10 years. The author and other veterinarians are now regularly seeing rabbits living to 9 or 10 years, the oldest reported in the author's practice being 14 years. Rabbits are herbivorous prey species with continually growing (elodont) teeth. This feature allows the geriatric rabbit to possess teeth that are essentially “new”, a distinct advantage over geriatric carnivores. Expanded longevity, while generally desirable, necessarily accompanies an increase in geriatric disorders. This article examines the spectrum of disease that can affect the geriatric rabbit as well as crucial factors concerning the clinical management of the animal up to the end of its life. An improved understanding of geriatric disorders in pet rabbits allows early recognition and the opportunity to improve quality of life. url: https://www.ncbi.nlm.nih.gov/pubmed/20159546/ doi: 10.1016/j.cvex.2009.09.002 id: cord-331452-y5lhawqo author: Lentz, Skyler title: High-Risk Airway Management in the Emergency Department: Diseases and Approaches Part I date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Background Successful airway management is critical to the practice of emergency medicine. Thus, emergency physicians must be ready to optimize and prepare for airway management in critically ill patients with a wide range of physiologic challenges. Challenges in airway management commonly encountered in the emergency department are discussed using a pearl and pitfall discussion in this first part of a two-part series. Objective This narrative review presents an evidence-based approach to airway and patient management during endotracheal intubation in challenging cases commonly encountered in the emergency department. Discussion Adverse events during emergent airway management are common with post-intubation cardiac arrest reported in as many as 1 in 25 intubations. Many of these adverse events can be avoided by proper identification and understanding the underlying physiology, preparation, and post intubation management. Those with high risk features including severe metabolic acidosis; shock and hypotension; obstructive lung disease; pulmonary hypertension, right ventricle failure, and pulmonary embolism; and severe hypoxemia must be managed with airway expertise. Conclusions This narrative review discusses the pearls and pitfalls of commonly encountered physiologic high-risk intubations with a focus on the emergency clinician. url: https://www.ncbi.nlm.nih.gov/pubmed/32563613/ doi: 10.1016/j.jemermed.2020.05.008 id: cord-275349-b35pt3mo author: Lenz, Heinz-Josef title: The Emergence of Baricitinib: A Story of Tortoises Versus Hares date: 2020-07-06 words: 1403.0 sentences: 63.0 pages: flesch: 37.0 cache: ./cache/cord-275349-b35pt3mo.txt txt: ./txt/cord-275349-b35pt3mo.txt summary: The artificial intelligence algorithms predicted that baricitinib would inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of cells [2] , (an effect later confirmed in human liver spheroids) [3] , combined with its better-known anti-inflammatory properties. Consequently, the combined potential antiviral and anti-inflammatory effects of this dually acting drug could be ideal for halting the progression of the disease in hospitalized patients, when taken for a limited duration. This new paper in the journal extends the previous published reports of baricitinib treatment in mild-tomoderate COVID19 patients and provides further evidence that baricitinib could be a potential treatment for unwell hospitalized patients with this disease, independent of severity. One would be advised to remain vigilant of such signals reflecting thromboembolic or infection risk in randomized controlled trials testing a variety of immunomodulatory therapies in COVID-19 patients, either alone or in combination, especially in view of associations between clots and SARS-CoV-2 infection [10] . abstract: nan url: https://doi.org/10.1093/cid/ciaa940 doi: 10.1093/cid/ciaa940 id: cord-312057-4zfaqkxm author: Leppla, Idris E. title: Optimizing Medication Treatment of Opioid Use Disorder During COVID-19 (SARS-CoV-2) date: 2020-05-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 health crisis joined, rather than supplanted, the opioid crisis as the most acutely pressing threats to US public health. In the setting of COVID-19, opioid use disorder treatment paradigms are being disrupted, including the fact that methadone clinics are scrambling to give “take-home” doses where they would typically not. The rapid transition away from in-person examination, dosing and group therapy in an era of social isolation calls for adjustments to clinical practice, including emphasizing patient-provider communication, favoring new inductees on buprenorphine and leveraging technology to optimize safety of medication treatment. url: https://doi.org/10.1097/adm.0000000000000678 doi: 10.1097/adm.0000000000000678 id: cord-007564-ljqrxjvv author: Leroy, O. title: 04 – Apport des explorations microbiologiques au diagnostic des infections des voies respiratoires basses date: 2006-11-13 words: 13542.0 sentences: 1229.0 pages: flesch: 54.0 cache: ./cache/cord-007564-ljqrxjvv.txt txt: ./txt/cord-007564-ljqrxjvv.txt summary: Trentetrois examens directs et 46 Ces données montrent que l''examen direct et la culture de l''expectoration dès lors qu''ils sont correctement effectués chez un patient sans antibiothérapie sont fréquemment positifs au cours des PAC à pneumocoque les plus graves, c''est-à-dire bactériémiques. Ces données ne doivent pas toutefois faire perdre de vue, comme le souligne Pesola [37] que dans plus de 10 % des cas, les PAC ont une étiologie plurimicrobienne et qu''il n''est peut être pas raisonnable de focaliser l''antibiothérapie uniquement sur le pneumocoque en cas de test positif. À partir d''échantillons provenant du tractus respiratoire inférieur (expectoration, voire prélèvements endoscopiques) ou supérieur (prélèvement nasopharyngé), un certain nombre de techniques ont été mises au point pour le diagnostic des infections liées à des germes tels que Chlamydia pneumoniae, Mycoplasma pneumoniae ou Legionella spp. abstract: The diagnosis of community-acquired pneumonia is usually based on clinical and radiological criteria. The identification of a causative organism is not required for the diagnosis. Although numerous microbiological techniques are available, their sensitivity and specificity are not high enough to guide first-line antimicrobial therapy. Consequently, this treatment remains most often empiric. If the causative organism is identified, the antimicrobial treatment is adapted. Sputum analysis may be proposed as a diagnostic tool for patients with an acute exacerbation of chronic obstructive pulmonary disease, in specific cases (prior antibiotherapy, hospitalization, failure of the empiric antimicrobial treatment). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119138/ doi: 10.1016/j.medmal.2006.07.008 id: cord-010844-y26y5myb author: Lessing, Noah L. title: Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why? date: 2020-04-29 words: 4431.0 sentences: 243.0 pages: flesch: 46.0 cache: ./cache/cord-010844-y26y5myb.txt txt: ./txt/cord-010844-y26y5myb.txt summary: OBJECTIVES: In a cohort of patients with traumatic spine injury (TSI) in Tanzania who did not undergo surgery, we sought to: (1) describe this nonoperative population, (2) compare outcomes to operative patients, and (3) determine predictors of nonoperative treatment. Patients with AO type A0/1/2/3 fractures (p < 0.001), ASIA E exams (p = 0.016), cervical spine injuries (p = 0.005), and central cord syndrome (p = 0.016) were more commonly managed nonoperatively. Surgery for TSI is offered in a small number of tertiary centers throughout Sub-Saharan Africa and other LMICs. Despite studies showing that nonoperative treatment is associated with worse outcomes [3] , operative rates remain low in resource-constrained settings [4, 5] . After multivariate analysis controlling for age, gender, insurance status, mechanism of injury, fracture stability, injury level, and exam on admission (ASIA grade), patients managed nonoperatively were 7.39 times more likely to die compared with patients undergoing surgery (95% CI: 2.18, 30.5 | p = 0.003) ( Table 3 ). abstract: STUDY DESIGN: Retrospective, cohort study of a prospectively collected database. OBJECTIVES: In a cohort of patients with traumatic spine injury (TSI) in Tanzania who did not undergo surgery, we sought to: (1) describe this nonoperative population, (2) compare outcomes to operative patients, and (3) determine predictors of nonoperative treatment. SETTING: Tertiary referral hospital. METHODS: All patients admitted for TSI over a 33-month period were reviewed. Variables included demographics, fracture morphology, neurologic exam, indication for surgery, length of hospitalization, and mortality. Regression analyses were used to report outcomes and predictors of nonoperative treatment. RESULTS: 270 patients met inclusion criteria, of which 145 were managed nonoperatively. Demographics between groups were similar. The nonoperative group was young (mean = 35.5 years) and primarily male (n = 125, 86%). Nonoperative patients had 7.39 times the odds of death (p = 0.003). Patients with AO type A0/1/2/3 fractures (p < 0.001), ASIA E exams (p = 0.016), cervical spine injuries (p = 0.005), and central cord syndrome (p = 0.016) were more commonly managed nonoperatively. One hundred and twenty-four patients (86%) had indications for but did not undergo surgery. After multivariate analysis, the only predictor of nonoperative management was sustaining a cervical injury (p < 0.001). CONCLUSIONS: Eighty-six percent of nonoperative TSI patients had an indication for surgery. Nonoperative management was associated with an increased risk of mortality. Cervical injury was the single independent risk factor for not undergoing surgery. The principle reason for nonoperative management was cost of implants. While a causal relationship between nonoperative management and inferior outcomes cannot be made, efforts should be made to provide surgery when indicated, regardless of a patient’s ability to pay. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222864/ doi: 10.1038/s41393-020-0474-y id: cord-297518-6y2uzcde author: Leulseged, T. W. title: Determinants of Developing Symptomatic Disease in Ethiopian COVID-19 Patients date: 2020-10-13 words: 3323.0 sentences: 181.0 pages: flesch: 50.0 cache: ./cache/cord-297518-6y2uzcde.txt txt: ./txt/cord-297518-6y2uzcde.txt summary: Results: The result of the multivariable binary logistic regression shows that age group (AOR= 1.818, 95% CI= 1.210, 2.731, p-value=0.004 for 30-39 years; AOR= 1.611, 95% CI= 1.016, 2.554, p-value=0.043 for 40-49 years and AOR= 4.076, 95% CI= 2.582, 6.435, p-value=0.0001 for years and above), sex (AOR= 1.672, 95% CI= 1.216, 2.299, p-value=0.002) and history of diabetes mellitus (AOR= 2.406, 95% CI= 1.384, 4.181, p-value=0.002) were found to be significant factors that determine the development of symptomatic disease in COVID-19 patients. . https://doi.org/10.1101/2020.10.09.20209734 doi: medRxiv preprint Therefore, the objective of this study was to assess the determinants of having symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia. Based on the chi-square/ Fischer''s exact test result, a significant difference in the presence of symptom was found among the different age groups, sex, different COVID-19 severity, those with a history of pre-existing co-morbid illness, cardiac disease, hypertension, diabetes mellitus, asthma and the need of oxygen supplement. abstract: Background: Studies show that having some symptoms seems to be associated with more severe disease and poor prognosis. Therefore, knowing who is more susceptible to symptomatic COVID-19 disease is important to provide targeted preventive and management practice. The aim of the study was to assess the determinants of having symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia. Methods: A case-control study was conducted from August to September 2020 among a randomly selected 765 COVID-19 patients (372 Asymptomatic and 393 Symptomatic patients). Chi-square test and independent t-test were used to detect the presence of a statistically significant difference in the characteristics of the cases (symptomatic) and controls (asymptomatic), where p-value of <0.05 considered as having a statistically significant difference. Multivariable binary logistic regression was used to assess a statistically significant association between the independent variables and developing symptomatic COVID-19 where Adjusted Odds ratio (AOR), 95% CIs for AOR, and P-values were used for testing significance and interpretation of results. Results: The result of the multivariable binary logistic regression shows that age group (AOR= 1.818, 95% CI= 1.210, 2.731, p-value=0.004 for 30-39 years; AOR= 1.611, 95% CI= 1.016, 2.554, p-value=0.043 for 40-49 years and AOR= 4.076, 95% CI= 2.582, 6.435, p-value=0.0001 for years and above), sex (AOR= 1.672, 95% CI= 1.216, 2.299, p-value=0.002) and history of diabetes mellitus (AOR= 2.406, 95% CI= 1.384, 4.181, p-value=0.002) were found to be significant factors that determine the development of symptomatic disease in COVID-19 patients. Conclusions: Developing a symptomatic COVID-19 disease was found to be determined by exposures of old age, male sex, and being diabetic. Therefore, patients with the above factors should be given enough attention in the prevention and management process, including inpatient management, to pick symptoms earlier and to manage accordingly so that these patients can have a favorable treatment outcome. url: https://doi.org/10.1101/2020.10.09.20209734 doi: 10.1101/2020.10.09.20209734 id: cord-326023-vwukiwe4 author: Leung, Char title: Risk factors for predicting mortality in elderly patients with COVID-19: a review of clinical data in China date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: While elderly patients are at high risk of fatality, research concerning COVID-19 has largely been done on clarifying the clinical features. As such, the present work aims to identify risk factors for mortality in elderly patients with COVID-19. Given that single-centre studies are less likely informative as elderly remains a minority in the total Chinese population, the present study reviewed the clinical data of geriatric COVID-19 patients gathered from different sources in the public domain. Based on the data of 154 individuals from 26 provinces, age remained a key mortality risk factor among geriatric patients of different ages. While dyspnoea and chest pain/discomfort were more commonly seen in deceased patients as they represented severe pneumonia, fever was more prominent in surviving patients. This was likely due to the lower baseline body temperature observed in elderly which translated to a lower maximum temperature of fever. However, lowering the threshold temperature for fever is not recommended in surveillance. Instead, baseline body temperature measured on a regular basis should be used to define the threshold temperature for fever. Against mixed results, more research should be done on identifying comorbidities associated with mortality in geriatric patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32353398/ doi: 10.1016/j.mad.2020.111255 id: cord-351823-ldbscq4s author: Leung, Marco Shiu Tsun title: COVID‐19 and Oncology: Service transformation during pandemic date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The COVID‐19 pandemic has challenged healthcare systems around the world, where resources have refocused on increasing critical bed capacity to prepare for the peak in incidence of COVID‐19. Oncology faces an unprecedented challenge as patients require multidisciplinary care and are more likely to be immunosuppressed. Services in oncology have been transformed using minimal resources over a short period of time. This transformation continues and telemedicine is playing a key role. AIMS: We explore how services in oncology have transformed to deliver services including consultations, systemic anticancer therapy, and surgery for patients, while shielding them from contracting COVID‐19. We assess the risks and benefits of the service transformation in the immediate, interim, and long term, and how telemedicine supports the process. METHODS: We performed a comprehensive review of the literature using suitable keywords on the search engines of PubMed, SCOPUS, Google Scholar, and latest official data from May to June 2020. RESULTS: Through the published literature on this topic, we discuss the transformations in oncology and the impact on patients and healthcare workers due to the COVID‐19 pandemic. We reflect on the lessions from COVID‐19 and assess the role of telemedicine in the future of oncology services. CONCLUSION: Transformation of services in oncology effectively shields patients from COVID‐19 infections, and telemedicine plays a role in virtual consultations. The long‐term effects are yet to be seen, such as safety of home‐based treatment, and effectiveness of virtual communication on patient care. As oncology requires a multidisciplinary approach, telemedicine will play a key role to improve patient‐centered cancer care in the future. url: https://doi.org/10.1002/cam4.3384 doi: 10.1002/cam4.3384 id: cord-018106-5giapmcf author: Levin, Jacqueline title: Mental Health Care for Survivors and Healthcare Workers in the Aftermath of an Outbreak date: 2019-05-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: When pandemics sweep across communities, they leave behind tremendous suffering in their wake. It is not only the illness that becomes a pandemic, but the same can be inferred about fear, mourning, and despair. The reverberations of loss are felt in a multitude of ways by those left behind. Often times, the mental health issues of affected persons and entire communities do not receive the attention they deserve in the light of other competing, immediate needs imparted by the devastation of the pandemic. This chapter aims to develop strategies for providing psychiatric care to survivors and their families, in the aftermath of a pandemic outbreak. Lastly, special considerations in the application of psychopharmacological interventions are reviewed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122898/ doi: 10.1007/978-3-030-15346-5_11 id: cord-012469-6cvu5umd author: Lewis, Jayne title: Speaking with Frankenstein date: 2020-08-21 words: 8505.0 sentences: 414.0 pages: flesch: 54.0 cache: ./cache/cord-012469-6cvu5umd.txt txt: ./txt/cord-012469-6cvu5umd.txt summary: As a professor of literature and a professor of medicine, we are especially interested in what it might mean to "speak with" Victor Frankenstein and his Creature because this process can provide creative insight into the relationships that develop between modern-day physicians and the patients incorporates distance and disappointment as well as recognition and rehabilitation, unresolved fear as well as pragmatic hope. In treating Victor "as if" he were the medical doctor he is training to become and the Creature his perceived difficult patient, we do not place Shelley''s novel in a cultural history of medicine that it might be seen to allegorize. Speaking with Victor''s failure helps us imagine physicians who, instead of mirroring societal fears of decay and death, find the courage to stand with the patients they have helped to birth into a new life story. At the very least, we sense in Victor''s evasion of responsibility new openings to speak about the ethical relationship between physicians and patients. abstract: This collaborative essay experimentally applies the insights of Mary Shelley's 1818 gothic fantasy Frankenstein to clinical interactions between present-day physicians and the patients they, akin to Shelley's human protagonist, so often seem to bring (back) to life. Because that process is frequently fraught with unspoken elements of ambivalence, disappointment, frustration, and failure, we find in Shelley's speculative fiction less a cautionary tale of overreach than a dynamic parable of the role that the unspoken, the invisible, and the unknown might play in contemporary physician/patient relationships. Playing with that parable, we consider its relevance to four often unacknowledged dynamics that shape physician/patient interaction: commitment to a false binary of life and death; the tyranny of normative aesthetics; shared negative affect; and the ethics of care and care-denial. To "speak with Frankenstein" is, we show, to make space for the otherwise unspeakable. The result is a more complete model of narrative medicine that accommodates to its ideal of open communication and full attention the persistence of what cannot be said, seen, or known--only imagined and approximated. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441016/ doi: 10.1007/s10912-020-09653-3 id: cord-004464-nml9kqiu author: Lhommet, Claire title: Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation? date: 2020-03-06 words: 4443.0 sentences: 235.0 pages: flesch: 43.0 cache: ./cache/cord-004464-nml9kqiu.txt txt: ./txt/cord-004464-nml9kqiu.txt summary: title: Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation? Whether the etiology of CAP is viral or bacterial should be determined based on the patient interview, clinical symptoms and signs, biological findings and radiological data from the very first hours of the patient''s presentation (a time when microbiological findings are typically not yet available). The aim of our study was to evaluate and compare the abilities of experienced physicians and a data-driven approach to answer this simple question within the first hours of a patient''s admission to the ICU for CAP: is it a viral or a bacterial pneumonia? Step 2: clinician and data-driven predictions of microbial etiology Clinicians and a mathematical algorithm were tasked with predicting the microbial etiology of pneumonia cases based on all clinical (43 items), and biological or radiological (17 items) information available in the first 3-h period after admission except for any microbiological findings (Supplementary Table 1 ). abstract: BACKGROUND: Community-acquired pneumonia (CAP) requires urgent and specific antimicrobial therapy. However, the causal pathogen is typically unknown at the point when anti-infective therapeutics must be initiated. Physicians synthesize information from diverse data streams to make appropriate decisions. Artificial intelligence (AI) excels at finding complex relationships in large volumes of data. We aimed to evaluate the abilities of experienced physicians and AI to answer this question at patient admission: is it a viral or a bacterial pneumonia? METHODS: We included patients hospitalized for CAP and recorded all data available in the first 3-h period of care (clinical, biological and radiological information). For this proof-of-concept investigation, we decided to study only CAP caused by a singular and identified pathogen. We built a machine learning model prediction using all collected data. Finally, an independent validation set of samples was used to test the pathogen prediction performance of: (i) a panel of three experts and (ii) the AI algorithm. Both were blinded regarding the final microbial diagnosis. Positive likelihood ratio (LR) values > 10 and negative LR values < 0.1 were considered clinically relevant. RESULTS: We included 153 patients with CAP (70.6% men; 62 [51–73] years old; mean SAPSII, 37 [27–47]), 37% had viral pneumonia, 24% had bacterial pneumonia, 20% had a co-infection and 19% had no identified respiratory pathogen. We performed the analysis on 93 patients as co-pathogen and no-pathogen cases were excluded. The discriminant abilities of the AI approach were low to moderate (LR+ = 2.12 for viral and 6.29 for bacterial pneumonia), and the discriminant abilities of the experts were very low to low (LR+ = 3.81 for viral and 1.89 for bacterial pneumonia). CONCLUSION: Neither experts nor an AI algorithm can predict the microbial etiology of CAP within the first hours of hospitalization when there is an urgent need to define the anti-infective therapeutic strategy. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060632/ doi: 10.1186/s12890-020-1089-y id: cord-259448-deya8dwn author: Li, Caixia title: Differential microRNA expression in the peripheral blood from human patients with COVID‐19 date: 2020-09-22 words: 2648.0 sentences: 172.0 pages: flesch: 56.0 cache: ./cache/cord-259448-deya8dwn.txt txt: ./txt/cord-259448-deya8dwn.txt summary: The expression levels of various miRNAs were detected by high‐throughput sequencing, and correlation analysis was performed on the target genes that are primed by miRNAs. KEY FINDINGS: Compared with the healthy controls, 35 miRNAs were upregulated and 38 miRNAs were downregulated in the human patients with COVID‐19. 16 In this study, to better understand the miRNA expression pattern in peripheral blood collected from human COVID-19 patients and healthy donors, high-throughput sequencing, and bioinformatics analysis were employed. The differential miRNA expression found in COVID-19 patients may regulate the immune responses and viral replication during viral infection. As shown in Figure 3 , there were significant differences in the miRNA expression between the COVID-19 patients and the control group. In the present study, the differential miRNA expression in peripheral blood from COVID-19 patients and healthy donors was observed. abstract: INTRODUCTION: The coronavirus disease (COVID‐19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which play important roles in regulating gene expression and are also considered as essential modulators during viral infection. The aim of this study was to elucidate the differential expression of miRNAs in COVID‐19. METHODS: The total RNA was extracted and purified from the peripheral blood of ten patients with COVID‐19 and four healthy donors. The expression levels of various miRNAs were detected by high‐throughput sequencing, and correlation analysis was performed on the target genes that are primed by miRNAs. KEY FINDINGS: Compared with the healthy controls, 35 miRNAs were upregulated and 38 miRNAs were downregulated in the human patients with COVID‐19. The top 10 genes were listed below: hsa‐miR‐16‐2‐3P,hsa‐miR‐5695,hsa‐miR‐10399‐3P,hsa‐miR‐6501‐5P,hsa‐miR‐361‐3P,hsa‐miR‐361‐3p, hsa‐miR‐4659a‐3p, hsa‐miR‐142‐5p, hsa‐miR‐4685‐3p, hsa‐miR‐454‐5p, and hsa‐miR‐30c‐5p. The 10 genes with the greatest reduction were listed below: hsa‐miR‐183‐5p, hsa‐miR‐627‐5p, hsa‐miR‐941, hsa‐miR‐21‐5p, hsa‐miR‐20a‐5p, hsa‐miR‐146b‐5p, hsa‐miR‐454‐3p, hsa‐miR‐18a‐5p, hsa‐miR‐340‐5p, and hsa‐miR‐17‐5p. Remarkably, miR‐16‐2‐3p was the most upregulated miRNA, with a 1.6‐fold change compared to that of the controls. Moreover, the expression of miR‐6501‐5p and miR‐618 was 1.5‐fold higher in the COVID‐19 patients than in the healthy donors. Meanwhile, miR‐627‐5p was the most downregulated miRNA, with a 2.3‐fold change compared to that of the controls. The expression of other miRNAs (miR‐183‐5p, miR‐627‐5p, and miR‐144‐3p) was reduced by more than 1.3‐fold compared to that of the healthy donors. Cluster analysis revealed that all of the differentially expressed miRNA target genes were clustered by their regulation of cellular components, molecular functions, and biological processes. Importantly, peptidases, protein kinases, and the ubiquitin system were shown to be the highest enrichment categories by enrichment analysis. CONCLUSIONS: The differential miRNA expression found in COVID‐19 patients may regulate the immune responses and viral replication during viral infection. url: https://doi.org/10.1002/jcla.23590 doi: 10.1002/jcla.23590 id: cord-298067-awo3smgp author: Li, Huanjie title: Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report date: 2020-07-10 words: 4853.0 sentences: 268.0 pages: flesch: 51.0 cache: ./cache/cord-298067-awo3smgp.txt txt: ./txt/cord-298067-awo3smgp.txt summary: Through associating infection symptoms with the transmission routes of virus and the patient course of the disease, we expect to provide guidelines for clinical diagnosis and the basis for suppressing the spread of the virus and antiviral treatment. On February 1, 2020, respiratory samples of four patients were confirmed SARS-CoV-2 infections by real-time PCR in Jinan Central Hospital, Shandong province, China. Summarizing the published articles, including SARS-CoV and SARS-CoV-2, we combined with epidemiological and clinical data to analyze the possible routes of asymptomatic patients with virus infection in order to provide the basis for suppressing the spread of the virus, and antiviral treatment and advice for the protection of medical staff. The study found that the detection of SARS-CoV-2 nucleic acid positive in a few feces of patients with confirmed COVID-19 cases indicated the presence of a live virus. abstract: The global outbreak of SARS-CoV-2 spread rapidly throughout the world which transmitted among humans through various routes. Asymptomatic (carriers) and possible fecal-oral transmission, resulted into a large-scale spread. These issues pose great challenges to disease diagnosis and epidemic control. We obtained data on 29 cases of COVID-19 patients in Jinan, China, and reported the clinical data of asymptomatic patients confirmed with stool samples positive. Some patients with gastrointestinal infections are secondary to pulmonary infections, and during the patients' recovery period, the virus may still existin the patient's gastrointestinal tract over 7 days. We combined with epidemiological and clinical data of asymptomatic patients to analyze the possible routes of viral transmission and infection, including eyes-nose, hands-eyes, fecal-oral, and eyes-oral, et al., thus first presented the two-way transmission through eyes-oral. Through associating infection symptoms with the transmission routes of virus and the patient course of the disease, we expect to provide guidelines for clinical diagnosis and the basis for suppressing the spread of the virus and antiviral treatment. url: https://www.ncbi.nlm.nih.gov/pubmed/32754600/ doi: 10.3389/fcell.2020.00618 id: cord-029547-9ei1ram3 author: Li, Jingwei title: The epidemiology and therapeutic options for the COVID-19 date: 2020-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: An outbreak of coronavirus disease 2019 (COVID-19), a disease caused by a novel pneumonia virus, has affected over 200 countries and regions worldwide. With the increasing number of patients and deaths, WHO have declared it as a global pandemic currently, indicating a third large-scale epidemic coronavirus has appeared since the emergence of severe acute respiratory syndrome coronavirus (SARS) and Middle-East respiratory syndrome (MERS) in the twenty-first century. Considering the great harm it has caused, researchers throughout the world have been chasing to exploit the pathophysiology, characteristics, and potential remedies for COVID-19 to better battle the outbreak. Therefore, the current study revisits advances of the virology, epidemiology, clinical features, therapeutic options, and prevention of COVID-19. The features of asymptomatic carriers are also been explored. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376264/ doi: 10.1093/pcmedi/pbaa017 id: cord-024893-pd67o7l8 author: Li, Lanjuan title: Translation: Expert Consensus on the Application of Artificial Liver Blood Purification System in the Treatment of Severe and Critical COVID-19: National Clinical Research Center for Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases date: 2020-04-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The prevention and treatment of COVID-19 nationwide has entered a tackling phase. Effective treatment of severe and critically ill patients is the key to reducing the fatality of the disease. The artificial liver blood purification system can remove inflammatory factors, alleviate the damage of the inflammatory response to the body, and has important value for the treatment of severe COVID-19. Led by Academician Lanjuan Li, based on the experience of treating patients across the country, integrating the opinions of experts from all over the country, the center summarized and formulated the consensus including the basic principles, treatment indications, relative contraindications, mode selection, monitoring indicators, and efficacy evaluation of artificial liver, which provides reference for treatment of severe COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227200/ doi: 10.1097/im9.0000000000000021 id: cord-305582-3hmsknon author: Li, Lei title: Therapeutic strategies for critically ill patients with COVID-19 date: 2020-04-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. Among people infected with the novel coronavirus (2019-nCoV), the intensive management of the critically ill patients in intensive care unit (ICU) needs substantial medical resource. In the present article, we have summarized the promising drugs, adjunctive agents, respiratory supportive strategies, as well as circulation management, multiple organ function monitoring and appropriate nutritional strategies for the treatment of COVID-19 in the ICU based on the previous experience of treating other viral infections and influenza. These treatments are referable before the vaccine and specific drugs are available for COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32307593/ doi: 10.1186/s13613-020-00661-z id: cord-266730-mio282vy author: Li, Long‐quan title: COVID‐19 patients'' clinical characteristics, discharge rate, and fatality rate of meta‐analysis date: 2020-03-23 words: 1309.0 sentences: 95.0 pages: flesch: 58.0 cache: ./cache/cord-266730-mio282vy.txt txt: ./txt/cord-266730-mio282vy.txt summary: We statistically analyzed the clinical symptoms and laboratory results of COVID‐19 patients and explained the discharge rate and fatality rate with a single‐arm meta‐analysis. The results of the random effects model meta-analysis showed that the fatality rate of the COVID-19 patients was 5% (95% CI 15, 27 found that the fatality rate of patients with viral pneumonia increased when they had a basic disease and mixed bacterial infection, which was consistent with the results of our study. Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia COVID-19 patients'' clinical characteristics, discharge rate, and fatality rate of meta-analysis abstract: The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID‐19 patients for clinical help. The clinical data of COVID‐19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID‐19 patients and explained the discharge rate and fatality rate with a single‐arm meta‐analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID‐19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C‐reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single‐arm meta‐analysis showed that the male took a larger percentage in the gender distribution of COVID‐19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID‐19 patients was 52% (95% CI [0.34,0.70]), and the fatality rate was 5% (95% CI [0.01,0.11]). url: https://doi.org/10.1002/jmv.25757 doi: 10.1002/jmv.25757 id: cord-339044-qy4jab37 author: Li, Man title: Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study date: 2020-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objectives: An outbreak of coronavirus disease (COVID-19) in 2019 in Wuhan, China, has spread quickly worldwide. However, the risk factors associated with COVID-19-related mortality remain controversial. Methods: A total of 245 adult patients with laboratory-confirmed COVID-19 from two centers were analyzed. Chi-square, Fisher's exact, and the Mann-Whitney U-tests were used to compare the clinical characteristics between the survivors and non-survivors. To explore the risk factors associated with in-hospital death, univariable and multivariable cox regression analyses were used. Results: Of the 245 patients included in this study, 23 (9.4%) died in the hospital. The multivariate regression analysis showed increased odds of in-hospital deaths associated with age, D-dimer levels >1,000 ng/L, platelet count <125, and higher serum creatinine levels. Conclusions: We identified risk factors that show significant association with mortality in adult COVID-19 patients, and our findings provide valuable references for clinicians to identify high-risk patients with COVID-19 at an early stage. url: https://www.ncbi.nlm.nih.gov/pubmed/32984387/ doi: 10.3389/fmed.2020.00545 id: cord-327820-4bm7b934 author: Li, Ning title: Management strategies for the burn ward during COVID-19 pandemic date: 2020-04-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract COVID-19 pandemic is sweeping the globe. Any outpatient or new inpatient especial in burn department during the pandemic should be as a potential infectious source of COVID-19. It is very important to manage the patients and wards carefully and correctly to prevent epidemic of the virus in burn centers. This paper provides some strategies regarding management of burn ward during the epidemic of COVID-19 or other respiratory infectious diseases. url: https://doi.org/10.1016/j.burns.2020.03.013 doi: 10.1016/j.burns.2020.03.013 id: cord-293180-f1ulk9ce author: Li, R W K title: Severe Acute Respiratory Syndrome (SARS) and the GDP. Part II: Implications for GDPs date: 2004-08-14 words: 4289.0 sentences: 295.0 pages: flesch: 51.0 cache: ./cache/cord-293180-f1ulk9ce.txt txt: ./txt/cord-293180-f1ulk9ce.txt summary: Special management protocols and modified measures that regulate droplet and aerosol contamination in a dental setting have to be introduced and may include the reduction or avoidance of droplet/aerosol generation, the disinfection of the treatment field, application of rubber dam, pre-procedural antiseptic mouthrinse and the dilution and efficient removal of contaminated ambient air. In the first part of this two-part article an account of the epidemiology, virology, pathology and management of Severe Acute Respiratory Syndrome (SARS) was provided together with public health issues and general aspects of infection control. On the other hand smaller droplets (or aerosols, generally under 10 µm in size) or small-particle residue of evaporated droplets are usually airborne and are entrained in the air for a lengthy period • SARS is a highly infectious disease and dental personnel are likely to be at risk because of the nature of their profession, working in close proximity to the patient. abstract: The transmission modes of SARS-coronavirus appear to be through droplet spread, close contact and fomites although air borne transmission has not been ruled out. This clearly places dental personnel at risks as they work in close proximity to their patients employing droplet and aerosol generating procedures. Although the principle of universal precautions is widely advocated and followed throughout the dental community, additional precautionary measures — termed standard precaution may be necessary to help control the spread of this highly contagious disease. Patient assessment should include questions on recent travel to SARS infected areas and, contacts of patients, fever and symptoms of respiratory infections. Special management protocols and modified measures that regulate droplet and aerosol contamination in a dental setting have to be introduced and may include the reduction or avoidance of droplet/aerosol generation, the disinfection of the treatment field, application of rubber dam, pre-procedural antiseptic mouthrinse and the dilution and efficient removal of contaminated ambient air. The gag, cough or vomiting reflexes that lead to the generation of aerosols should also be prevented. url: https://www.ncbi.nlm.nih.gov/pubmed/15311240/ doi: 10.1038/sj.bdj.4811522 id: cord-286334-d9v5xtx7 author: Li, Rui title: Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date: 2020-04-30 words: 12955.0 sentences: 719.0 pages: flesch: 50.0 cache: ./cache/cord-286334-d9v5xtx7.txt txt: ./txt/cord-286334-d9v5xtx7.txt summary: More detailed monitoring on how these physiological parameters change over time (perhaps including more complex cytokine studies), in these severely ill, influenza A(H1N1)pdm09-infected patients admitted to ICU-ECMO units, may eventually yield data to improve their management and clinical outcomes. 5 In the current study, we characterized a new HCV subtypes among chronic hepatitis C patients in Yunnan, China, initially designated as 6xi, further analyzed its evolutionary history and investigated its baseline RAS by next generation sequencing (NGS) method. The samples met the following inclusion criteria: (1) hepatitis C antibody-positive for 6 months with normal serum alanine aminotransferase (ALT) levels; (2) subject was residing in Yunnan province and was over 18 years old; (3) complete demographic information and clinical data were available; (4) consented to the use of patient information in studies on HCV epidemics; and (5) were treatment-naïve during sampling. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32092392/ doi: 10.1016/j.jinf.2020.02.013 id: cord-328484-4iptwc3n author: Li, Tao title: Clinical Characteristics of 312 Hospitalized Older Patients with COVID-19 in Wuhan, China date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: Much of the previous research on COVID-19 was based on all population. But substantial numbers of severe episodes occur in older patients. There is a lack of data about COVID-19 in older adults. The aims of this study were to analyze the clinical characteristics of older adult patients with COVID-19. METHODS: Retrospective study of older patients hospitalized with COVID-19 from February 1 st to March 31 st, 2020 was conducted in the Sino-French New City Branch of Tongjing Hospital in Wuhan, China. According to the degree of severity of COVID-19 during hospitalization, 312 older patients were divided into non-severe and severe cases. RESULTS: the mean age of the patients was 69.2 ± 7.3 years, and 47.4% of patients had exposure history. 77.2% of patients had a co-morbidity, with hypertension being the most common(57.1%), followed by diabetes(38.8%) and cardiovascular disease(29.8%). Multivariable regression showed increasing odds of severe COVID-19 associated with age(OR 1.59, 95%CI 1.13-2.08), SOFA score(OR 5.89, 95%CI 3.48-7.96), APACHEⅡ score(OR 3.13, 95%CI 1.85-5.62), platelet count＜125 × 10(9)/L(OR 2.36, 95%CI 1.03-4.14), d-dimer(OR 4.37, 95%CI 2.58-7.16), creatinine＞133 μmol/L(OR 1.85, 95%CI 1.12-3.04), interleukin-6(OR 4.32, 95%CI 2.07-7.13), and lung consolidation(OR 1.94, 95%CI 1.45-4.27) on admission. The most common complication was acute respiratory distress syndrome(35.6%), followed by acute cardiac injury(33.0%) and coagulation disorders(30.8%). 91.7% of patients were prescribed antiviral therapy, followed by immune globulin(52.9%) and systemic glucocorticoids(43.6%). 21.8% of patients received invasive ventilation, 1.92% for extracorporeal membrane oxygenation. The overall mortality was 6.73%, and mortality of severe patients was 17.1%, which was higher than non-severe patients(0.962%). CONCLUSIONS: Older patients with COVID-19 had much more co-morbidity, complications and mortality. More attention should be paid to older patients with COVID-19. url: https://doi.org/10.1016/j.archger.2020.104185 doi: 10.1016/j.archger.2020.104185 id: cord-307258-66lwpblq author: Li, Weixia title: Anesthesia Management and Perioperative Infection Control in Patients With the Novel Coronavirus date: 2020-03-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Anesthesiologists have a high risk of infection with COVID-19 during perioperative care and as first responders to airway emergencies. The potential of becoming infected can be reduced by a systematic and integrated approach that assesses infection risk. The latter leads to an acceptable choice of materials and techniques for personal protection and prevention of cross-contamination to other patients and staff. The authors have presented a protocolized approach that uses diagnostic criteria to clearly define benchmarks from the medical history along with clinical symptoms and laboratory tests. Patients can then be rapidly assigned into 1 of 3 risk categories that direct the choice of protective materials and/or techniques. Each hospital can adapt this approach to develop a system that fits its individual resources. Educating medical staff about the proper use of high-risk areas for containment serves to protect staff and patients. url: https://api.elsevier.com/content/article/pii/S1053077020302846 doi: 10.1053/j.jvca.2020.03.035 id: cord-274556-531jlpwr author: Li, Wenrui title: Impact of COVID-19 on Peripheral Arterial Disease Treatment date: 2020-06-02 words: 253.0 sentences: 23.0 pages: flesch: 56.0 cache: ./cache/cord-274556-531jlpwr.txt txt: ./txt/cord-274556-531jlpwr.txt summary: key: cord-274556-531jlpwr title: Impact of COVID-19 on Peripheral Arterial Disease Treatment With the conditions of PAD patients getting more serious when they come to the hospital, it is necessary to choose appropriate treatment to control perioperative complications and mortality. Prior to this, it is more important for patients to maintain the medical treatment of PAD [3] . Also, continuity of follow-up is key [4] , it is necessary to evaluate the patient''s condition through telephone and phone application (obtain pictures of the patient''s ischemia limb), and urge them to go to hospital in time when the condition worsens. Finally, on the basis of controlling the covid-19 pandemic, daily medical activities should be resumed as soon as possible to provide reasonable treatment for more patients with PAD. Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia Thinking beyond the box: preparing for the end of COVID-19 outbreak in a vascular surgery department abstract: nan url: https://api.elsevier.com/content/article/pii/S089050962030460X doi: 10.1016/j.avsg.2020.05.045 id: cord-269087-f9hyntvf author: Li, X. title: A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19 date: 2020-04-04 words: 4280.0 sentences: 236.0 pages: flesch: 49.0 cache: ./cache/cord-269087-f9hyntvf.txt txt: ./txt/cord-269087-f9hyntvf.txt summary: Results: We included 25 published literature references related to the epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. The risk factors which may suggest severe or critical progress for children are: Fast respiratory rate and/or; lethargy and drowsiness mental state and/or; lactate progressively increasing and/or; imaging showed bilateral or multi lobed infiltration, pleural effusion or rapidly expending of lesions in a short period of time and/or; less than 3 months old or those who underly diseases. To help better understand how it would affect children and what is the latest specific clinical and research finding on children with it, we provide a mini-review based on 25 literature references covering the fields of epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. According to the current literature on the pediatric cases, children confirmed with COVID-19 mostly had good prognosis, with considerably less severe to critical progress (5.9%) as compared to adult patients (18.5%). abstract: Background: As the novel coronavirus triggering COVID-19 has broken out in Wuhan, China and spread rapidly worldwide, it threatens the lives of thousands of people and poses a global threat on the economies of the entire world. However, infection with COVID-19 is currently rare in children. Objective To discuss the latest findings and research focus on the basis of characteristics of children confirmed with COVID-19, and provide an insight into the future treatment and research direction. Methods: We searched the terms "COVID-19 OR coronavirus OR SARS-CoV-2" AND "Pediatric OR children" on PubMed, Embase, Cochrane library, NIH, CDC, and CNKI. The authors also reviewed the guidelines published on Chinese CDC and Chinese NHC. Results: We included 25 published literature references related to the epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. Conclusion: The numbers of children with COVID-19 pneumonia infection are small, and most of them come from family aggregation. Symptoms are mainly mild or even asymptomatic, which allow children to be a risk factor for transmission. Thus, strict epidemiological history screening is needed for early diagnosis and segregation. This holds especially for infants, who are more susceptible to infection than other age groups in pediatric age, but have most likely subtle and unspecific symptoms. They need to be paid more attention to. CT examination is a necessity for screening the suspected cases, because most of the pediatric patients are mild cases, and plain chest X-ray do not usually show the lesions or the detailed features. Therefore, early chest CT examination combined with pathogenic detection is a recommended clinical diagnosis scheme in children. The risk factors which may suggest severe or critical progress for children are: Fast respiratory rate and/or; lethargy and drowsiness mental state and/or; lactate progressively increasing and/or; imaging showed bilateral or multi lobed infiltration, pleural effusion or rapidly expending of lesions in a short period of time and/or; less than 3 months old or those who underly diseases. For those critical pediatric patients with positive SARS-CoV-2 diagnosis, polypnea may be the most common symptom. For treatment, the elevated PCT seen in children in contrast to adults suggests that the underlying coinfection/secondary infection may be more common in pediatric patients and appropriate antibacterial treatment should be considered. Once cytokine storm is found in these patients, anti-autoimmune or blood-purifying therapy should be given in time. Furthermore, effective isolation measures and appropriate psychological comfort need to be provided timely. url: https://doi.org/10.1101/2020.03.30.20044545 doi: 10.1101/2020.03.30.20044545 id: cord-286477-0euaaspo author: Li, Xiaochen title: Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan date: 2020-04-12 words: 3243.0 sentences: 190.0 pages: flesch: 57.0 cache: ./cache/cord-286477-0euaaspo.txt txt: ./txt/cord-286477-0euaaspo.txt summary: This study aims to describe and compare the 141 epidemiological, demographic, clinical, laboratory and radiological characteristics as well as the 142 complications, treatment and outcomes of hospitalized patients with nonsevere and severe 143 COVID-19. Comparison of findings between nonsevere and severe cases in 223 the patients with positive viral nucleic acid test pre-admission showed essentially the similar 224 differences to that in the total patients (see Table E1 in the Online Repository). In the follow-up period, the complications of COVID-19 were assessed , including acute 297 respiratory distress syndrome (ARDS) (38.3%), cardiac injury (21.7%), liver dysfunction (19.3%), 298 acute kidney injury (17.3%), bacteremia (7.7%), diffuse intravascular coagulation (7.7%), and 299 hyperglycemia (33.2%) ( This study provided a comprehensive data on the epidemiological, demographic, clinical, 338 laboratory, and radiological characteristics as well as the complications, treatment, and outcomes 339 of hospitalized patients with nonsevere and severe COVID-19 in Wuhan. abstract: Abstract Background In December 2019, COVID-19 outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. Objective The severity on admission, complications, treatment, and outcomes of COVID-19 patients were evaluated. Methods Patients with COVID-19 admitted to Tongji Hospital from January 26, 2020 to February 5, 2020 were retrospectively enrolled and followed-up until March 3, 2020. Potential risk factors for severe COVID-19 were analyzed by a multivariable binary logistic model. Cox proportional hazard regression model was used for survival analysis in severe patients. Results We identified 269 (49.1%) of 548 patients as severe cases on admission. Elder age, underlying hypertension, high cytokine levels (IL-2R, IL-6, IL-10, and TNF-a), and high LDH level were significantly associated with severe COVID-19 on admission. The prevalence of asthma in COVID-19 patients was 0.9%, markedly lower than that in the adult population of Wuhan. The estimated mortality was 1.1% in nonsevere patients and 32.5% in severe cases during the average 32 days of follow-up period. Survival analysis revealed that male, elder age, leukocytosis, high LDH level, cardiac injury, hyperglycemia, and high-dose corticosteroid use were associated with death in patients with severe COVID-19. Conclusions Patients with elder age, hypertension, and high LDH level need careful observation and early intervention to prevent the potential development of severe COVID-19. Severe male patients with heart injury, hyperglycemia, and high-dose corticosteroid use may have high risk of death. url: https://api.elsevier.com/content/article/pii/S0091674920304954 doi: 10.1016/j.jaci.2020.04.006 id: cord-282704-qg2o0ug4 author: Li, Xun title: Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China date: 2020-02-25 words: 2257.0 sentences: 159.0 pages: flesch: 60.0 cache: ./cache/cord-282704-qg2o0ug4.txt txt: ./txt/cord-282704-qg2o0ug4.txt summary: title: Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China Methods The clinical records, laboratory findings and radiologic assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. All 25 dead patients with COVID-19 tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by use of RT-PCR on samples from there respiratory tract. In the presents study, all the patients were died of respiratory failure, which indicated that the lung is the most common target organ of SARS-CoV-2. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study abstract: Summary Background The pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2) is a highly infectious disease, which was occurred in Wuhan, Hubei Province, China in December 2019. As of February 13, 2020, a total of 59883 cases of COVID-19 in China have been confirmed and 1368 patients have died from the disease. However, the clinical characteristics of the dyed patients were still not clearly clarified. This study aims to summarize the clinical characteristics of death cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. Methods The clinical records, laboratory findings and radiologic assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. Two experienced clinicians reviewed and abstracted the data. Findings The mean age of the dead was 71.48 years, the average course of the disease was 10.56 days, all patients eventually died of respiratory failure. All of those who died had underlying diseases, the most common of which was hypertension (16/25, 64%), followed by diabetes (10/25, 40%), heart diseases (8/25, 32%), kidney diseases (5/25, 20%), cerebral infarction (4/25, 16%), chronic obstructive pulmonary disease (COPD, 2/25, 8%), malignant tumors (2/25, 8%) and acute pancreatitis (1/25, 4%). The most common organ damage outside the lungs was the heart, followed by kidney and liver. In the patients' last examination before death, white blood cell and neutrophil counts were elevated in 17 patients (17/25, 68%) and 18 patients (18/25, 72%), lymphocyte counts were decreased in 22 patients (22/25, 88%). Most patients' PCT, CRP and SAA levels were elevated, the percentages were 90.5% (19/21), 85% (19/20) and 100% (21/21) respectively. The levels of the last test of neutrophils (15/16, 93.8%), PCT (11/11, 100%), CRP (11/13, 84.6%), cTnI (8/9, 88.9%), D-Dimer (11/12, 91.6%) and LDH (9/9, 100%) were increased as compared to the first test, while the levels of lymphocytes were decreased (14/16, 87.5%). Interpretation The age and underlying diseases (hypertension, diabetes, etc.) were the most important risk factors for death of COVID-19 pneumonia. Bacterial infections may play an important role in promoting the death of patients. Malnutrition was common to severe patients. Multiple organ dysfunction can be observed, the most common organ damage was lung, followed by heart, kidney and liver. The rising of neutrophils, SAA, PCT, CRP, cTnI, D-Dimer and LDH levels can be used as indicators of disease progression, as well as the decline of lymphocytes counts. url: https://doi.org/10.1101/2020.02.19.20025239 doi: 10.1101/2020.02.19.20025239 id: cord-289930-7xm6q68s author: Li, Yang title: Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational study date: 2020-08-21 words: 4331.0 sentences: 199.0 pages: flesch: 42.0 cache: ./cache/cord-289930-7xm6q68s.txt txt: ./txt/cord-289930-7xm6q68s.txt summary: In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation, namely, the therapeutic window. According to the currently known molecular mechanisms and pathophysiology data on severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS), and influenza patients, critically ill patients usually undergo the following stages: virus invasion, immune activation, excessive inflammatory response, acute respiratory distress syndrome (ARDS), and, in the end, possible recovery or death [6] [7] [8] [9] [10] [11] . Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids could benefit patients with LDH levels of less than two times ULN, who may be in the early phase of excessive inflammation. Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids could benefit patients with LDH levels of less than two times ULN, who may be in the early phase of excessive inflammation. abstract: Critically ill patients with coronavirus diseases 2019 (COVID-19) are of grave concern. Those patients usually underwent a stage of excessive inflammation before developing acute respiratory distress syndrome. In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation, namely, the therapeutic window. Among a Shanghai cohort and a validation cohort, we enrolled COVID-19 patients showing marked radiographic progression. Short-term, low-to-moderate-dose corticosteroids were considered for them. After identifying the possible markers for the therapeutic window, we then divided the patients, based on whether they were treated with corticosteroids within the therapeutic window, into the early-start group and control group. We identified that the therapeutic window for corticosteroids was characterized by a marked radiographic progression and lactase dehydrogenase (LDH) less than two times the upper limit of normal (ULN). The Shanghai cohort comprised of 68 patients, including 47 in the early-start group and 21 in the control group. The proportion of patients requiring invasive mechanical ventilation was significantly lower in the early-start group than in the control group (10.6% vs. 33.3%, difference, 22.7%, 95% confidence interval 2.6–44.8%). Among the validation cohort of 51 patients, similar difference of the primary outcome was observed (45.0% vs. 74.2%, P = 0.035). Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids benefits patients with LDH levels of less than two times the ULN, who may be in the early phase of excessive inflammation. url: https://doi.org/10.1080/22221751.2020.1807885 doi: 10.1080/22221751.2020.1807885 id: cord-330050-05nnihst author: Li, Yang title: Emergency trauma care during the outbreak of corona virus disease 2019 (COVID-19) in China date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: A novel coronavirus pneumonia outbreak began in Wuhan, Hubei Province, in December 2019; the outbreak was caused by a novel coronavirus previously never observed in humans. China has imposed the strictest quarantine and closed management measures in history to control the spread of the disease. However, a high level of evidence to support the surgical management of potential trauma patients during the novel coronavirus outbreak is still lacking. To regulate the emergency treatment of trauma patients during the outbreak, we drafted this paper from a trauma surgeon perspective according to practical experience in Wuhan. MAIN BODY: The article illustrates the general principles for the triage and evaluation of trauma patients during the outbreak of COVID-19, indications for emergency surgery, and infection prevention and control for medical personnel, providing a practical algorithm for trauma care providers during the outbreak period. CONCLUSIONS: The measures of emergency trauma care that we have provided can protect the medical personnel involved in emergency care and ensure the timeliness of effective interventions during the outbreak of COVID-19. url: https://doi.org/10.1186/s13017-020-00312-5 doi: 10.1186/s13017-020-00312-5 id: cord-028907-m9psxg1f author: Li, Yi title: Extended antiplatelet therapy with clopidogrel alone versus clopidogrel plus aspirin after completion of 9- to 12-month dual antiplatelet therapy for ACS patients with both high bleeding and ischemic risk. Rationale and design of the OPT-BIRISK double blinded, placebo controlled randomized trial date: 2020-07-09 words: 3535.0 sentences: 165.0 pages: flesch: 42.0 cache: ./cache/cord-028907-m9psxg1f.txt txt: ./txt/cord-028907-m9psxg1f.txt summary: BACKGROUND: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is the cornerstone for prevention ischemic events in patients with acute coronary syndromes (ACS) and undergoing percutaneous coronary intervention (PCI). J o u r n a l P r e -p r o o f 3 / 21 Background Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is the cornerstone to prevent stent thrombosis and atherothrombotic events in patients with acute coronary syndromes (ACS) and/or undergoing percutaneous coronary intervention (PCI) [1] [2] [3] . In order to test this hypothesis, we designed the Optimal antiPlatelet Therapy for high Bleeding and Ischemic RISK patients (OPT-BIRISK) trial, to determine if extended clopidogrel monotherapy will be superior to DAPT with clopidogrel and aspirin following completion of 9 to 12 months DAPT for ACS patients who received drug eluting stent (DES) implantation and possess both high bleeding and high ischemic characteristics. abstract: BACKGROUND: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is the cornerstone for prevention ischemic events in patients with acute coronary syndromes (ACS) and undergoing percutaneous coronary intervention (PCI). However, the optimal antiplatelet strategy for ACS patients with both high bleeding and high ischemic risks is unclear. STUDY DESIGN: The Optimal antiPlatelet Therapy for patients with high Bleeding and Ischemic RISK (OPT-BIRISK) trial is a multicenter, double blinded, placebo controlled, randomized study designed to test the superiority of extended antiplatelet therapy with clopidogrel monotherapy compared with aspirin and clopidogrel for reduction of bleeding events in ACS patients with both high bleeding and high ischemic risks (“bi-risk”). A total of 7700 patients who completed 9- to 12-month DAPT after new generation drug eluting stent implantation for the treatment of ACS will be randomized to receive clopidogrel monotherapy or aspirin plus clopidogrel for 9 months, followed by aspirin monotherapy for 3 months. The primary end point is Bleeding Academic Research Consortium type 2, 3 or 5 bleedings at 9 months after randomization. The key secondary endpoint is major adverse cardiac and cerebral events at 9 months after randomization, defined as a composite of all-cause death, myocardial infarction, stroke or coronary artery revascularization. CONCLUSION: OPT-BIRISK is the first large scale, randomized trial aimed to explore the optimal antiplatelet strategy for bi-risk ACS patients after PCI in current clinical practice. The results will add evidence regarding de-escalation antiplatelet therapy for patients at special risk. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346838/ doi: 10.1016/j.ahj.2020.07.005 id: cord-318808-1cfwj5uq author: Li, Ying title: Comparison of Hospitalized Patients with pneumonia caused by COVID-19 and influenza A in children under 5 years date: 2020-06-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Background Since the outbreak of Coronavirus Disease 2019 (COVID-19) in Wuhan, considerable attention has been paid on its epidemiology and clinical characteristics in children patients. However, it is also crucial for clinicians to differentiate COVID-19 from other respiratory infectious diseases, such as influenza viruses. Methods This was a retrospective study. Two group of COVID-19 patients (n=57) and influenza A patients (n=59) were enrolled. We analyzed and compared their clinical manifestations, imaging characteristics and treatments. Results The proportions of cough (70.2%), fever (54.4%) and gastrointestinal symptoms (14.1%) in COVID-19 patients were lower than those of influenza A patients (98.3%, P<0.001; 84.7%, P<0.001; and 35.6%, P=0.007; respectively). In addition, COVID-19 patients showed significantly lower levels of leukocytes (7.87 vs. 9.89×109/L, P=0.027), neutrophils (2.43 vs. 5.16×109/L, P<0.001), C-reactive protein (CRP; 3.7 vs. 15.1mg/L, P=0.001) and procalcitonin (PCT; 0.09 vs. 0.68mm/h, P<0.001), while lymphocyte levels (4.58 vs. 3.56×109/L; P=0.006) were significantly higher compared with influenza A patients. In terms of CT imaging, ground-glass opacification in chest CT was more common in COVID-19 patients than in influenza A patients (42.1% vs. 15%, P=0.032). In contrast, consolidation was more common in influenza A patients (25%) than that in COVID-19 patients (5.2%, P=0.025). Conclusion The clinical manifestations and laboratory tests of COVID-19 children are milder than those of influenza A children under 5 years. Additionally, imaging results more commonly presented as ground-glass opacities in COVID-19 patients. url: https://www.sciencedirect.com/science/article/pii/S1201971220304628?v=s5 doi: 10.1016/j.ijid.2020.06.026 id: cord-272427-jqs00ilp author: Li, Yu-xuan title: The impact of COVID-19 on gastric cancer surgery: a single-center retrospective study date: 2020-10-02 words: 2656.0 sentences: 166.0 pages: flesch: 50.0 cache: ./cache/cord-272427-jqs00ilp.txt txt: ./txt/cord-272427-jqs00ilp.txt summary: After admission during the COVID period, the waiting time before surgery was longer (PCG: 3[IQR: 2,5] vs. Based on our experiences during the pandemic period, we propose some surgical strategies for gastric cancer patients. We aimed to compare the differences in demographics, baseline characteristics, clinicopathological features, and health economics between the two groups to investigate the feasibility of gastric surgery during the pandemic of COVID-19. These data included patient demographics and baseline characteristics (sex, age, body mass index, comorbidity, clinical TNM classification, pathological TNM classification, hemoglobin, CEA, CA199, AFP, CA724), origin of patients (from local district or other provinces), operative method (open surgery or laparoscopic surgery), operating time, estimated blood loss, postoperative complications, postoperative fever, waiting time before admission, length of postoperative hospital stay, hospital costs etc. Length of postoperative hospital stay was defined as the period from the time when patient had undergone surgery to discharge. In conclusion, there are no studies on the impact of COVID-19 on gastric cancer patients. abstract: BACKGROUND: The coronavirus disease 2019 (COVID-19) has been declared a global pandemic by the World Health Organization. Patients with cancer are more likely to incur poor clinical outcomes. Due to the prevailing pandemic, we propose some surgical strategies for gastric cancer patients. METHODS: The ‘COVID-19’ period was defined as occurring between 2020 and 01-20 and 2020-03-20. The enrolled patients were divided into two groups, pre-COVID-19 group (PCG) and COVID-19 group (CG). A total of 109 patients with gastric cancer were enrolled in this study. RESULTS: The waiting time before admission increased by 4 days in the CG (PCG: 4.5 [IQR: 2, 7.8] vs. CG: 8.0 [IQR: 2,20]; p = 0.006). More patients had performed chest CT scans besides abdominal CT before admission during the COVID-19 period (PCG: 22 [32%] vs. CG: 30 [73%], p = 0.001). After admission during the COVID period, the waiting time before surgery was longer (PCG: 3[IQR: 2,5] vs. CG: 7[IQR: 5,9]; p < 0.001), more laparoscopic surgeries were performed (PCG: 51[75%] vs. CG: 38[92%], p = 0.021), and hospital stay period after surgery was longer (7[IQR: 6,8] vs.9[IQR:7,11]; p < 0.001). In addition, the total cost of hospitalization increased during this period, (PCG: 9.22[IQR:7.82,10.97] vs. CG: 10.42[IQR:8.99,12.57]; p = 0.006). CONCLUSION: This study provides an opportunity for our surgical colleagues to reflect on their own services and any contingency plans they may have to tackle the COVID-19 crisis. url: https://doi.org/10.1186/s12893-020-00885-7 doi: 10.1186/s12893-020-00885-7 id: cord-287373-7xjn05k8 author: Lian, Xin title: Under the coronavirus disease 2019(COVID-19) pandemic circumstance, how to administrate cancer patients with fever during radiotherapy date: 2020-06-05 words: 374.0 sentences: 23.0 pages: flesch: 54.0 cache: ./cache/cord-287373-7xjn05k8.txt txt: ./txt/cord-287373-7xjn05k8.txt summary: key: cord-287373-7xjn05k8 title: Under the coronavirus disease 2019(COVID-19) pandemic circumstance, how to administrate cancer patients with fever during radiotherapy cord_uid: 7xjn05k8 2.The screen process of patient with fever during radiotherapy in the center. All fever patients were screened by fever clinic with COVID 2019 nucleic acid, Patients with fever had been suspended from radiation therapy until the outcome of negative screen test results and the relive of fever symptoms, the average duration of suspension was 5.5 days (3-11), see figure 2 for details. It is suggested that fever patients with anti-tumor therapy during COVID-19 epidemic should carefully be concerned. Scientific and reasonable arrangements for the treatment and strict screen procedure for fever patient will ensure the maximization of the rights and interests of cancer patients. Risk of COVID-19 for patients with cancer COVID-19 outbreak and cancer patient management: viewpoint from radio-oncologists abstract: nan url: https://doi.org/10.1016/j.radonc.2020.05.049 doi: 10.1016/j.radonc.2020.05.049 id: cord-307309-s0t4kp2x author: Liang, Ying title: Symptoms, Management and Healthcare Utilization of COPD Patients During the COVID-19 Epidemic in Beijing date: 2020-10-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Social distancing and restriction measures during the COVID-19 epidemic may have impacts on medication availability and healthcare utilization for COPD patients, and thereby affect standard disease management. We aimed to investigate the change of respiratory symptoms, pharmacological treatment and healthcare utilization of COPD patients during the epidemic in Beijing, China. METHODS: We conducted a single-center, cross-sectional survey performed at Peking University Third Hospital and recruited patients with COPD who were interviewed by phone call. Clinical data, including respiratory symptoms, pharmacological treatment, management and healthcare access before and during the COVID-19 epidemic from January 25 to April 25, 2020, were collected. RESULTS: A total of 153 patients were enrolled for analysis. Before the epidemic, 81.7% (125/153) had long-term maintenance medication and ICS/LABA (60.8%) and LAMA (57.5%) were most commonly used. During the epidemic, 75.2% (115/153) maintained their pharmacological treatment and 6.5% (10/153) had to reduce or stop taking medications, with a slight decrease of patients taking ICS/LABA (53.6%) and LAMA (56.9%). Most of the patients [76.5% (117/153)] had a low symptom burden, with a CAT score <10 during the epidemic. Of 153 patients, 45 (29.4%) patients reported worsening of respiratory symptoms but only 15.6% (7/45) sought medical care in hospitals, while the remaining expressed concerns about cross-infection in the hospital (55.5%, 25/45) or had mild symptoms which were managed by themselves (28.8%, 13/45). CONCLUSION: During the COVID-19 epidemic in Beijing, most of our COPD patients maintained their long-term pharmacological treatment and had mild-to-moderate symptoms. Approximately, 30.0% of the patients experienced worsening of respiratory symptoms, but most of them did not seek medical care in the hospital due to concerns about cross-infection. url: https://www.ncbi.nlm.nih.gov/pubmed/33116465/ doi: 10.2147/copd.s270448 id: cord-339467-ewqxf02j author: Liang, Ying title: Differential diagnosis of coronavirus disease 2019 from pneumonias caused by other etiologies in a fever clinic in Beijing date: 2020-10-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32947360/ doi: 10.1097/cm9.0000000000001121 id: cord-030216-l38i06v2 author: Liao, Kuang-Ming title: Hospital costs and prognosis in end-stage renal disease patients receiving coronary artery bypass grafting date: 2020-08-08 words: 3702.0 sentences: 198.0 pages: flesch: 44.0 cache: ./cache/cord-030216-l38i06v2.txt txt: ./txt/cord-030216-l38i06v2.txt summary: METHODS: This study analyzed data from the National Health Insurance Research Database in Taiwan for patients who were diagnosed with ESRD and received CABG (ICD-9-CM codes 585 or 586) between January 1, 2004, and December 31, 2009. There have been limited studies investigating the prognosis, risk factors and hospital costs of CABG between ESRD and non-ESRD patients. Thus, the aim of our study was to assess whether ESRD patients on hemodialysis who received CABG experienced higher hospital costs and perioperative and postoperative mortality than CABG patients without ESRD and to evaluate the factors related to outcomes between the two groups. Second, the risk factors for mortality after CABG were hypertension, diabetes, myocardial infarction history, stroke and COPD in ESRD patients compared with non-ESRD patients. ESRD patients with regular hemodialysis, old age, diabetes, and hypertension are at increased risk of stroke [23] [24] [25] , but our study found that these factors were not significantly associated with mortality among ESRD patients after CABG. abstract: BACKGROUND: Coronary artery disease is common in patients with end-stage renal disease (ESRD). Patients with ESRD are a high-risk group for cardiac surgery and have increased morbidity and mortality. Most studies comparing ESRD patients receiving coronary artery bypass grafting (CABG) or percutaneous coronary intervention have found that the long-term survival is good in ESRD patients after CABG. The aim of our study was to compare ESRD patients who underwent CABG with the general population who underwent CABG, in terms of prognosis and hospital costs. METHODS: This study analyzed data from the National Health Insurance Research Database in Taiwan for patients who were diagnosed with ESRD and received CABG (ICD-9-CM codes 585 or 586) between January 1, 2004, and December 31, 2009. The ESRD patients included in this study all received catastrophic illness cards with the major illness listed as ESRD from the Ministry of Health and Welfare in Taiwan. The control subjects were randomly selected patients without ESRD after propensity score matching with ESRD patients according to age, gender, and comorbidities at a 2:1 ratio from the same dataset. RESULTS: A total of 48 ESRD patients received CABG, and their mean age was 62.04 ± 10.04 years. Of these patients, 29.2% were aged ≥70 years, and 66.7% were male. ESRD patients had marginally higher intensive care unit (ICU) stays (11.06 vs 7.24 days) and significantly higher ICU costs (28,750 vs 17,990 New Taiwan Dollars (NTD)) than non-ESRD patients. Similarly, ESRD patients had significantly higher surgical costs (565,200 vs. 421,890 NTD), a higher perioperative mortality proportion (10.4% vs 2.1%) and a higher postoperative mortality proportion (33.3% vs 11.5%) than non-ESRD patients. CONCLUSIONS: After CABG, ESRD patients had a higher risk of mortality than non-ESRD patients, and ICU and surgery costs were also higher among the ESRD patients than among patients without ESRD. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414285/ doi: 10.1186/s12882-020-01972-w id: cord-337115-vtjsigod author: Liao, Xuelian title: Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province, China date: 2020-02-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s00134-020-05954-2 doi: 10.1007/s00134-020-05954-2 id: cord-256618-tt3p0tki author: Liao, Yun title: Role of pharmacists during the COVID‐19 pandemic in China ‐ Shanghai Experiences date: 2020-06-14 words: 2484.0 sentences: 155.0 pages: flesch: 46.0 cache: ./cache/cord-256618-tt3p0tki.txt txt: ./txt/cord-256618-tt3p0tki.txt summary: They work with pharmacists at SPHCC, having responsibilities that include drug supplies, dispensing, pharmacy intravenous admixture services (PIVAS), prescription audits, medication reconciliations, pharmacotherapy, therapeutic drug monitoring, and patient education. Fangcang, which sounds similar to Noah''s Ark in Chinese, is a large, temporary hospital built by converting public venues, such as stadiums and exhibition halls, into health care facilities to isolate patients with mild to moderate symptoms of an infectious disease from their families and communities, while providing medical care, disease monitoring, food, shelter, and social activities. They work with the 35 pharmacists and 5 clinical pharmacists at SPHCC, having responsibilities over drug supplies, dispensing, pharmacy intravenous admixture services (PIVAS), prescription audits, medication reconciliations, pharmacotherapy, therapeutic drug monitoring (TDM), and patient education. According to the criteria stated in the "Expert Consensus on Comprehensive Treatment of COVID-19 in Shanghai", 4 individuals with an epidemiological history (resided in or visited an epidemic area within 14 days) and clinical symptoms (fever or respiratory symptoms, imaging features, decreased lymphocyte count) are considered suspected cases. abstract: The roles and contributions of pharmacists in Shanghai during the coronavirus disease 2019 (COVID‐19) pandemic are described in this report. Five pharmacists have been appointed as members of an expert interdisciplinary health care team tasked with taking care of all adult COVID‐19 patients in Shanghai in a designated hospital, the Shanghai Public Health Clinical Center (SPHCC). They work with pharmacists at SPHCC, having responsibilities that include drug supplies, dispensing, pharmacy intravenous admixture services (PIVAS), prescription audits, medication reconciliations, pharmacotherapy, therapeutic drug monitoring, and patient education. Due to the pandemic, pharmacy operations in all hospitals are modified to adhere to guidelines for infection risk mitigation and personnel protection. Community pharmacies serve as the public access point to health care and medical supplies, providing services beyond dispensing and medication counselling. The establishment of internet hospitals (telehealth facilities) provide new opportunities for delivering pharmaceutical care and working with health care professionals. Pharmacists also participate in evaluating new treatments and keeping health care teams informed of new findings for potential treatment considerations. In response to the critical need for health care professionals in Wuhan, 68 pharmacists from Shanghai went there to work with the local pharmacists. Through assuming new roles and adapting existing practice, pharmacists have acquired invaluable experiences for future practice advancement. In order to assume these responsibilities effectively, pharmacists need to be equipped with the necessary skills for meeting the evolving health care challenges. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32838221/ doi: 10.1002/jac5.1288 id: cord-293086-6282sb6b author: Liddell, Kathleen title: Who gets the ventilator? Important legal rights in a pandemic date: 2020-05-11 words: 5502.0 sentences: 268.0 pages: flesch: 48.0 cache: ./cache/cord-293086-6282sb6b.txt txt: ./txt/cord-293086-6282sb6b.txt summary: 2 As a result, at present, the only central guidance comes from the ''COVID-19 Rapid Guideline'' issued by the National Institute for Health and Care Excellence (NICE), which recommends triaging admission to the ICU based on frailty assessments, but provides little concrete guidance on how to allocate or re-allocate ventilators once a patient is in the ICU. At present, the prognostic tools required to produce an effective decision support system (triage protocol) are lacking along with most of the infrastructure, processes, legal protections, and training for critical care triage.'' 13 It is difficult to attribute relative probabilities of survival to patients, or to anticipate length of bed stay, with a novel disease like COVID-19. Thus, if ventilation is clinically indicated, it is doubtful that doctors can Current controversy unilaterally decide to withhold care on the grounds that a scarce resource would be more effectively used on future (anticipated) patients. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32393471/ doi: 10.1136/medethics-2020-106332 id: cord-318909-h5b7mncf author: Liguori, Claudio title: Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Coronavirus disease 2019 (COVID-19) represents a novel pneumonia leading to severe acute respiratory syndrome (SARS). Recent studies documented that SARS-Coronavirus2 (SARS-CoV2), responsible for COVID-19, can affect the nervous system. The aim of the present observational study was to prospectively assess subjective neurological symptoms (sNS) in patients with SARS-CoV2 infection. METHODS: We included patients hospitalized at the University Hospital of Rome Tor Vergata, medical center dedicated to the treatment of patients with COVID-19 diagnosis, who underwent an anamnestic interview about sNS consisting of 13 items, each related to a specific symptom, requiring a dichotomized answer. RESULTS: We included 103 patients with SARS-CoV2 infection. Ninety-four patients (91.3%) reported at least one sNS. Sleep impairment was the most frequent symptom, followed by dysgeusia, headache, hyposmia, and depression. Women more frequently complained hyposmia, dysgeusia, dizziness, numbeness/paresthesias, daytime sleepiness, and muscle ache. Moreover, muscle ache and daytime sleepiness were more frequent in the first 2 days after admission. Conversely, sleep impairment was more frequent in patients with more than 7 days of hospitalization. In these patients we also documented higher white blood cells and lower C-reactive protein levels. These laboratory findings correlated with the occurrence of hyposmia, dysgeusia, headache, daytime sleepiness, and depression. CONCLUSIONS: Patients with SARS-CoV2 infection frequently present with sNS. These symptoms were present from the early phases of the disease. The possibly intrinsic neurotropic properties of SARS-CoV2 may justify the very high frequency of sNS. Further studies targeted at investigating the consequences of SARS-CoV2 infection on the CNS should be planned. url: https://www.sciencedirect.com/science/article/pii/S088915912030876X?v=s5 doi: 10.1016/j.bbi.2020.05.037 id: cord-295514-vhymj0rw author: Lim, Peter A title: Impact of a viral respiratory epidemic on the practice of medicine and rehabilitation: Severe acute respiratory syndrome date: 2004-08-01 words: 5277.0 sentences: 244.0 pages: flesch: 43.0 cache: ./cache/cord-295514-vhymj0rw.txt txt: ./txt/cord-295514-vhymj0rw.txt summary: Severe acute respiratory syndrome (SARS) is a new respiratory viral epidemic that originated in China but has affected many parts of the world, with devastating impact on economies and the practice of medicine and rehabilitation. Rehabilitation was significantly affected by SARS, because strict infection control measures run counter to principles such as multidisciplinary interactions, patients encouraging and learning from each other, and close physical contact during therapy. Rehabilitation medicine was increasingly affected by everstricter infection control measures regarding close contacts and interactions between health care workers. Rehabilitation medicine was directly affected when the entire neurology ward, including patients and health care staff, were transferred out to TTSH for isolation and observation because of suspicious clusters of fevers that involved both patients and staff. Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts abstract: Lim PA, Ng YS, Tay BK. Impact of a viral respiratory epidemic on the practice of medicine and rehabilitation: severe acute respiratory syndrome. Arch Phys Med Rehabil 2004;85:1365–70. Severe acute respiratory syndrome (SARS) is a new respiratory viral epidemic that originated in China but has affected many parts of the world, with devastating impact on economies and the practice of medicine and rehabilitation. A novel coronavirus has been implicated, with transmission through respiratory droplets. Rehabilitation was significantly affected by SARS, because strict infection control measures run counter to principles such as multidisciplinary interactions, patients encouraging and learning from each other, and close physical contact during therapy. Immunocompromised patients who may silently carry SARS are common in rehabilitation and include those with renal failure, diabetes, and cancer. Routine procedures such as management of feces and respiratory secretions (eg, airway suctioning, tracheotomy care) have been classified as high risk. Personal protection equipment presented not only a physical but also a psychologic barrier to therapeutic human contact. Visitor restriction to decrease chances of disease transmission are particularly difficult for long-staying rehabilitation patients. At the height of the epidemic, curtailment of patient movement stopped all transfers for rehabilitation, and physiatrists had to function as general internists. Our experiences strongly suggest that rehabilitation institutions should have emergency preparedness plans because such epidemics may recur, whether as a result of nature or of bioterrorism. url: https://www.ncbi.nlm.nih.gov/pubmed/15295768/ doi: 10.1016/j.apmr.2004.01.022 id: cord-302862-znnlyz3y author: Lim, Peter A.C. title: Transverse Myelitis date: 2019-04-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Transverse myelitis (TM) is an inflammatory condition across the spinal cord, along one or more levels and in the absence of compression. Idiopathic acute TM is rare and with improvements in diagnostic tools and longer follow-up, the etiology which may include post-infectious, multiple sclerosis, or neuromyelitis optica often becomes clearer. The patient may present acutely with weakness, sensory impairments, or bowel and bladder changes. A careful history, physical examination, and appropriate diagnostic studies including blood tests and an MRI scan may help determine the diagnosis and etiology. Following the acute management, which may include use of steroids, immunosuppressive drugs, and plasma exchange, a comprehensive medical rehabilitation program is important to optimize recovery from the resultant impairments and disabilities and manage associated complications. Complications such as paralysis, autonomic dysfunction, neuropathic and musculoskeletal pain, spasticity, contractures, neurogenic bladder and bowels, skin breakdown, and psychological issues will benefit from the expertise of the physiatrist. Rehabilitation will include functional restoration with therapy as well as compensation of residual impairment with mobility and various other assistive devices. url: https://api.elsevier.com/content/article/pii/B9780323549479001620 doi: 10.1016/b978-0-323-54947-9.00162-0 id: cord-260679-tm1s6wvj author: Lim, Wei Shen title: Pneumonia—Overview date: 2020-05-20 words: 6874.0 sentences: 358.0 pages: flesch: 38.0 cache: ./cache/cord-260679-tm1s6wvj.txt txt: ./txt/cord-260679-tm1s6wvj.txt summary: Within the grouping of hospital-acquired pneumonia (HAP), further distinction is usually made according to whether the patient was on an intensive care unit, or intubated (ventilator-acquired pneumonia (VAP)) at the time of infection (Torres et al., 2017; Kalil et al., 2016) . A definitive diagnosis of pneumonia comprises four aspects: (i) symptoms and signs of a respiratory tract infection, (ii) radiological changes, (iii) identification of a putative pathogen and (iv) a treatment response, or clinical course, consistent with pneumonia. A meta-analysis of individual participant data from 26 RCTs found that PCT-directed treatment in the management of acute respiratory tract infections (of varying types and severity, including CAP and HAP) was associated with a reduction in antibiotic exposure (5.0 vs. The respiratory pathogens commonly implicated in patients with CAP remain important aetiological agents in all other types of pneumonia, including HAP and pneumonia in the immunocompromised host (Table 8 ). abstract: Pneumonia is very common and continues to exact a high burden on health. The Global Burden of Disease Study 2015 found lower respiratory infections (LRIs) were the leading infectious cause of death and the fifth leading cause of death overall. Pneumococcal pneumonia caused 55% of LRI deaths in all ages (1.5 million deaths). Novel pathogens, particularly viruses, continue to emerge as causes of pneumonia. The rise of drug-resistance among common respiratory pathogens is a further challenge. Pneumonia is commonly classified according to patient location at the time of infection, leading to the categories of community-acquired, hospital-acquired and ventilator-acquired pneumonia. url: https://api.elsevier.com/content/article/pii/B9780128012383116368 doi: 10.1016/b978-0-12-801238-3.11636-8 id: cord-305520-7gxmdo56 author: Lim, Wei Sing title: Widefield imaging with Clarus fundus camera vs slit lamp fundus examination in assessing patients referred from the National Health Service diabetic retinopathy screening programme date: 2020-10-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To compare diabetic retinopathy (DR) grading and management plan between virtual review using widefield Clarus imaging and macular optical coherence tomography (OCT) versus slit lamp clinical examination and macular OCT. METHOD: New referrals over 3 months from the National Diabetic Eye Screening programme (DESP) were screened. Patients who had both Clarus widefield imaging and macular OCT were included. All patients underwent slit lamp examination in clinic. Data obtained from electronic patient records included referral reason, DR grading and management plan. Two graders retrospectively reviewed imaging and formulated a management plan blinded to results from patients’ clinic visit. Results from virtual examination were compared with those from slit lamp examination. RESULTS: One-hundred and two eyes of 51 patients were assessed. 11 fundus photos from 7 patients and 15 fundus photos from 10 patients were deemed inadequate by grader G1 and G2, respectively. Eighteen (35%) patients and 11 (22%) patients from virtual assessment by G1 and G2, respectively were found to need a face a face appointment to aid diagnosis. Compared to slit lamp examination, 15% and 7.5% of patients from G1 and G2’s virtual assessment respectively had different proposed management plan. Agreement of DR grading between both virtual graders and slit lamp examination was fair (Kappa’s coefficient = 0.56). One case of slit lamp noted retinal neovascularization, which was graded as background retinopathy by DESP was also graded as such on virtual assessment. CONCLUSION: Widefield Clarus and OCT imaging allowed two-thirds of DESP referrals to be safely managed virtually. url: https://www.ncbi.nlm.nih.gov/pubmed/33082533/ doi: 10.1038/s41433-020-01218-x id: cord-344693-znw3dru4 author: Lima, Brian title: COVID‐19 in recent heart transplant recipients: Clinicopathologic features and early outcomes date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The impact of COVID‐19 on heart transplant (HTx) recipients remains unclear, particularly in the early post‐transplant period. METHODS: We share novel insights from our experience in five HTx patients with COVID‐19 (three within 2 months post‐transplant) from our institution at the epicenter of the pandemic. Results: All five exhibited moderate (requiring hospitalization, n = 3) or severe (requiring ICU and/or mechanical ventilation, n = 2) illness. Both cases with severe illness were transplanted approximately 6 weeks before presentation and acquired COVID‐19 through community spread. All five patients were on immunosuppressive therapy with mycophenolate mofetil (MMF) and tacrolimus, and three that were transplanted within the prior 2 months were additionally on prednisone. The two cases with severe illness had profound lymphopenia with markedly elevated C‐reactive protein, procalcitonin, and ferritin. All had bilateral ground‐glass opacities on chest imaging. MMF was discontinued in all five, and both severe cases received convalescent plasma. All three recent transplants underwent routine endomyocardial biopsies, revealing mild (n = 1) or no acute cellular rejection (n = 2), and no visible viral particles on electron microscopy. Within 30 days of admission, the two cases with severe illness remain hospitalized but have clinically improved, while the other three have been discharged. CONCLUSIONS: COVID‐19 appears to negatively impact outcomes early after heart transplantation. url: https://doi.org/10.1111/tid.13382 doi: 10.1111/tid.13382 id: cord-339504-8svo2w3u author: Lima, Rodrigo Moreira e title: Recommendations for local-regional anesthesia during the COVID-19 pandemic date: 2020-06-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Since the beginning of the COVID-19 pandemic, many questions have come up regarding safe anesthesia management of patients with the disease. Regional anesthesia, whether peripheral nerve or neuraxial, is a safe alternative for managing patients with COVID-19, by choosing modalities that mitigate pulmonary function involvement. Adopting regional anesthesia mitigates adverse effects in the post-operative period and provides safety to patients and teams, as long as there is compliance with individual protection and interpersonal transmission care measures. Respecting contra-indications and judicial use of safety techniques and norms are essential. The present manuscript aims to review the evidence available on regional anesthesia for patients with COVID-19 and offer practical recommendations for safe and efficient performance. url: https://api.elsevier.com/content/article/pii/S0104001420300890 doi: 10.1016/j.bjane.2020.06.002 id: cord-350401-suefuurq author: Lima-Setta, Fernanda title: Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study()()() date: 2020-11-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To describe the clinical, laboratory, and radiological characteristics, as well as the outcomes of children with MIS-C. METHOD: Multicenter, prospective cohort study, conducted in 17 pediatric intensive care units in five states in Brazil, from March to July 2020. Patients from 1 month to 19 years who met the MIS-C diagnostic criteria were included consecutively. RESULTS: Fifty-six patients were included, with the following conditions: Kawasaki-like disease (n = 26), incomplete Kawasaki disease (n = 16), acute cardiac dysfunction (n = 10), toxic shock syndrome (n = 3), and macrophage activation syndrome (n = 1). Median age was 6.2 years (IQR 2.4-10.3), 70% were boys, 59% were non-whites, 20% had comorbidities, 48% reported a contact with COVID-19 cases, and 55% had a recent SARS-CoV-2 infection confirmed by RT-PCR and/or serology. Gastrointestinal symptoms were present in 71%, shock symptoms in 59%, and severe respiratory symptoms in less than 20%. D-dimer was increased in 80% and cardiac dysfunction markers in more than 75%. Treatment included immunoglobulin (89%); corticosteroids, antibiotics, and enoxaparin in about 50%; and oseltamivir and antifungal therapy in less than 10%. Only 11% needed invasive mechanical ventilation, with a median duration of five days (IQR 5-6.5). The median length of PICU stay was six days (IQR 5-11), and one death occurred (1.8%). CONCLUSIONS: Most characteristics of the present MIS-C patients were similar to that of other cohorts. The present results may contribute to a broader understanding of SARS-CoV-2 infection in children and its short-term consequences. Long-term multidisciplinary follow-up is needed, since it is not known whether these patients will have chronic cardiac impairment or other sequelae. url: https://api.elsevier.com/content/article/pii/S0021755720302254 doi: 10.1016/j.jped.2020.10.008 id: cord-011649-3dlsy8fl author: Limoncelli, Janine title: General Anesthesia Recommendations for Electroconvulsive Therapy During the Coronavirus Disease 2019 Pandemic date: 2020-06-12 words: 1636.0 sentences: 80.0 pages: flesch: 44.0 cache: ./cache/cord-011649-3dlsy8fl.txt txt: ./txt/cord-011649-3dlsy8fl.txt summary: 2 Early guidance from the Anesthesia Patient Safety Foundation and other sources regarding airway management in COVID-19positive patients has recommended rapid sequence intubation and avoidance of mask ventilation to reduce the risk of droplet spread and aerosolization of virus. 3 Given the penetrance of COVID-19 in the New York metropolitan area, the Weill Cornell Medicine NewYork-Presbyterian Hospital Anesthesiology and Psychiatry departments collaborated to develop guidelines to ensure that the patients who were in urgent need of ECTwere provided that care while minimizing exposure to the staff and potential spread of disease to other ECT patients. Whereas anesthesia for ECT had been performed by a single anesthesiologist in the past, the donning and doffing of PPE in addition to the necessity of ensuring complete mask fit if positive pressure ventilation is used require 2 anesthesia providers to be available at all times. abstract: Coronavirus disease 2019 is an infectious viral disease first identified in December 2019 in Wuhan, China, and very rapidly spread globally resulting in a pandemic. Common symptoms include fever, cough, and shortness of breath. Although the majority of patients recover, there are still a significant number of patients who progress to respiratory failure, multiorgan failure, and death. The virus is mainly spread during close contact and by small droplets produced by coughing, sneezing, or talking. Because of the highly contagious element and easy spread in a communal living arrangement that exists within an inpatient psychiatric hospitals, the following guidelines were established to improve patient and staff safety while still maintaining efficiency and capability to provide this needed treatment to a subgroup of patients. OBJECTIVE: The objective of this study was to devise a safe and efficient methodology to deliver potential lifesaving electroconvulsive therapy to inpatients during the coronavirus disease 2019 pandemic. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299092/ doi: 10.1097/yct.0000000000000705 id: cord-004342-9uok77wb author: Lin, Chun-Yu title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date: 2020-02-14 words: 3003.0 sentences: 160.0 pages: flesch: 36.0 cache: ./cache/cord-004342-9uok77wb.txt txt: ./txt/cord-004342-9uok77wb.txt summary: title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience This retrospective study aimed to clarify the shortand mid-term outcomes of elderly patients who underwent surgery to treat left-sided native valve infective endocarditis (LSNIE). The elderly group had a higher predicted mortality rate and a lower incidence of preoperative septic emboli-related complications. In this single-centre study, a comparative cohort of patients who underwent surgical treatment for active LSNIE is presented, which includes 38 elderly patients aged >65 years. Due to the increase in average life expectancy and the higher incidence of cardiovascular disease with advancing age, more elderly patients nowadays present for cardiac surgery 22 . Therefore, we suggest that a guideline-directed surgical strategy according to the presence of complications, which include embolism events, large vegetation, heart failure, or uncontrolled infection, would be beneficial to improve the mid-term outcomes of elderly patients with LSNIE. abstract: This retrospective study aimed to clarify the short- and mid-term outcomes of elderly patients who underwent surgery to treat left-sided native valve infective endocarditis (LSNIE). Between July 2005 and September 2015, 179 patients underwent surgical treatment for active LSNIE at a single institution. Patients were classified into two groups: ≥65 years (elderly group) and <65 years (non-elderly group). Clinical features, surgical information, postoperative complications, and three-year survival rates were compared. The average ages were 74.2 ± 6.4 and 45.2 ± 12.6 years in the elderly and non-elderly groups, respectively. The elderly group had a higher predicted mortality rate and a lower incidence of preoperative septic emboli-related complications. Echocardiographic assessments of infected valves were generally homogenous between the groups. The elderly patients had a higher in-hospital mortality rate than the non-elderly patients (26.3% vs. 5.7%, P = 0.001). For patients who survived to discharge, the three-year cumulative survival rates were 75.0% ± 8.2% and 81.2% ± 3.4% in the elderly and non-elderly groups, respectively (P = 0.484). In conclusion, elderly patients are at a higher risk of in-hospital mortality after surgery for LSNIE. However, once elderly patients are stabilized by surgical treatment and survive to discharge, the mid-term outcomes are promising. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021775/ doi: 10.1038/s41598-020-59657-1 id: cord-005587-8iwsvku9 author: Lindén, Viveka title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation date: 2000-10-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objectives: To evaluate the results of treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO), minimal sedation, and pressure supported ventilation. Design and setting: Observational study in a tertiary referral center, Intensive Care Unit, Astrid Lindgren Children's Hospital at Karolinska Hospital, Stockholm, Sweden. Subjects and methods: Seventeen adult patients with ARDS were treated with venovenous or venoarterial ECMO after failure of conventional therapy. The Murray score of pulmonary injury averaged 3.5 (3.0–4.0) and the mean PaO(2)/FIO(2) ratio was 46 (31–65). A standard ECMO circuit with nonheparinized surfaces was used. The patients were minimally sedated and received pressure-supported ventilation. High inspiratory pressures were avoided and arterial saturation as low as 70% was accepted on venovenous bypass. Results: In one patient a stable bypass could not be established. Among the remaining 16 patients 13 survived (total survival rate 76%) after 3–52 days (mean 15) on bypass. Major surgical procedures were performed in several patients. The cause of death in the three nonsurvivors was intracranial complications leading to total cerebral infarction. Conclusion: A high survival rate can be obtained in adult patients with severe ARDS using ECMO and pressure-supported ventilation with minimal sedation. Surgical complications are amenable to surgical treatment during ECMO. Bleeding problems can generally be controlled but require immediate and aggressive approach. It is difficult or impossible to decide when a lung disease is irreversible, and prolonged ECMO treatment may be successful even in the absence of any detectable lung function. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094942/ doi: 10.1007/s001340000697 id: cord-320599-hxn4bgec author: Liontos, Michalis title: Chemotherapy resumption in ovarian cancer patient diagnosed with COVID-19 date: 2020-07-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: • Chemotherapy resumption after convalescence from COVID-19 is safe and feasible. • No guidelines exist for resumption of chemotherapy in patients with COVID-19. • Cancer patients on chemotherapy may develop SARS-CoV-2 antibodies less frequently. url: https://doi.org/10.1016/j.gore.2020.100615 doi: 10.1016/j.gore.2020.100615 id: cord-303349-0kn7apl3 author: Lippi, Giuseppe title: Hemoglobin value may be decreased in patients with severe coronavirus disease 2019 date: 2020-04-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2531137920300298 doi: 10.1016/j.htct.2020.03.001 id: cord-334773-yw2qgv13 author: Lisco, Giuseppe title: Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Epidemiological data suggest that comorbid patients, mostly those with type 2 diabetes (T2D), are predisposed to poor prognosis in Coronavirus disease 2019 (COVID-19), leading to serious healthcare concerns. The aim of the present manuscript is to review the main relevant mechanisms possibly contributing to worsen the clinical course of COVID-19 in T2D. RESULTS: Poor glucose control, high glycaemic variability and diabetes-related comorbidities at baseline, particularly cardiovascular diseases and obesity, contribute in worsening the prognosis in the above-mentioned cluster of patients. Moreover, both a lower efficient innate immune system response and cytokine dysregulation predispose patients with T2D to impaired viral clearance and more serious pulmonary and systemic inflammation once the SARS-CoV-2 infection occurred. Inconclusive data are currently available for specifically indicate or contraindicate concurrent medications for managing T2D and its comorbidities in infected patients. CONCLUSIONS: T2D individuals should be considered as more vulnerable to COVID-19 than general population, and thus require adequate advices about hygienic tips to protect themselves during the pandemic. A careful management of glucose levels and diabetes-related comorbidities remains essential for avoiding further complications, and patient monitoring during the pandemic should be performed also at distance by means of telemedicine. Further studies are needed to clarify whether medications normally used for managing T2D and its associated comorbidities could have a protective or detrimental effect on COVID-19 clinical course. url: https://doi.org/10.1007/s12020-020-02444-9 doi: 10.1007/s12020-020-02444-9 id: cord-345371-pjbviagq author: Lisi, Lucia title: Approaching Coronavirus Disease 2019: mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2 date: 2020-07-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: On March 11, 2020, the World Health Organization (WHO) declared the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As of July 2020, SARS-CoV-2 has infected more than 14 million people and provoked more than 590,000 deaths, worldwide. From the beginning, a variety of pharmacological treatments has been empirically used to cope with the life-threatening complications associated with Corona Virus Disease 2019 (COVID-19). Thus far, only a couple of them and not consistently across reports have been shown to further decrease mortality, respect to what can be achieved with supportive care. In most cases, and due to the urgency imposed by the number and severity of the patients’ clinical conditions, the choice of treatment has been limited to repurposed drugs, approved for other indications, or investigational agents used for other viral infections often rendered available on a compassionate-use basis. The rationale for drug selection was mainly, though not exclusively, based either i) on the activity against other coronaviruses or RNA viruses in order to potentially hamper viral entry and replication in the epithelial cells of the airways, and/or ii) on the ability to modulate the excessive inflammatory reaction deriving from dysregulated host immune responses against the SARS-CoV-2. In several months, an exceptionally large number of clinical trials have been designed to evaluate the safety and efficacy of anti-COVID-19 therapies in different clinical settings (treatment or pre- and post-exposure prophylaxis) and levels of disease severity, but only few of them have been completed so far. This review focuses on the molecular mechanisms of action that have provided the scientific rationale for the empirical use and evaluation in clinical trials of structurally different and often functionally unrelated drugs during the SARS-CoV-2 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32710969/ doi: 10.1016/j.bcp.2020.114169 id: cord-335916-fh28qrt7 author: Liu, Cuiwei title: COVID-19 in cancer patients: risk, clinical features, and management date: 2020-08-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the world, prompting the World Health Organization to declare the coronavirus disease of 2019 (COVID-19) a public health emergency of international concern. Cancer patients are regarded as a highly vulnerable population to SARS-CoV-2 infection and development of more severe COVID-19 symptoms, which is possibly due to the systemic immunosuppressive state caused directly by tumor growth and indirectly by effects of anticancer treatment. Currently, much effort has been directed toward studying the pathogenesis and treatment of COVID-19, but the risk profiles, prognoses, and treatment outcomes in cancer patients remain unclear. Based on the current literature, we summarize the risk profiles, clinical and biochemical characteristics, and therapy outcomes of COVID-19 infections in cancer patients. The challenges in the clinical care of cancer patients with COVID-19 are discussed. The goal of this review is to stimulate research to better understand the biological impact and prognoses of COVID-19 infections in cancer patients, thus facilitating improvement of the clinical management of these patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32944387/ doi: 10.20892/j.issn.2095-3941.2020.0289 id: cord-343308-5i31ysee author: Liu, Juan title: Detection of SARS‐CoV‐2 by RT‐PCR in anal from patients who have recovered from coronavirus disease 2019 date: 2020-04-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: An outbreak of coronavirus disease 2019 (COVID‐19) pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), started in Wuhan City, Hubei Province, China. The real‐time reverse‐ transcriptase polymerase ‐ chain ‐ reaction (RT ‐ PCR) method can be used for the detection of SARS‐CoV‐2 in oral swabs(1). Now, results have confirmed the presence of the live virus in stool samples from patients with COVID‐ 19(2). This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32285947/ doi: 10.1002/jmv.25875 id: cord-268254-1mg7a17c author: Liu, Li title: High neutralizing antibody titer in intensive care unit patients with COVID-19 date: 2020-07-20 words: 3475.0 sentences: 200.0 pages: flesch: 53.0 cache: ./cache/cord-268254-1mg7a17c.txt txt: ./txt/cord-268254-1mg7a17c.txt summary: This study determined the seroprevalence of 733 non-COVID-19 individuals from April 2018 to February 2020 in the Hong Kong Special Administrative Region and compared the neutralizing antibody (NAb) responses of eight COVID-19 patients admitted to the intensive care unit (ICU) with those of 42 patients not admitted to the ICU. In this study, the absence of NAb in the serum of over 733 HKSAR residents indicates that SARS-CoV-2 is unlikely to have spread silently in Hong Kong before its emergence in COVID-19 patients. During our manuscript revision, a preprint paper indicated that SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease [26] . Neutralizing antibodies responses to SARS-CoV-2 in COVID-19 inpatients and convalescent patients. SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications. abstract: Coronavirus disease 2019 (COVID-19) has a wide spectrum of disease severity from mild upper respiratory symptoms to respiratory failure. The role of neutralizing antibody (NAb) response in disease progression remains elusive. This study determined the seroprevalence of 733 non-COVID-19 individuals from April 2018 to February 2020 in the Hong Kong Special Administrative Region and compared the neutralizing antibody (NAb) responses of eight COVID-19 patients admitted to the intensive care unit (ICU) with those of 42 patients not admitted to the ICU. We found that NAb against SARS-CoV-2 was not detectable in any of the anonymous serum specimens from the 733 non-COVID-19 individuals. The peak serum geometric mean NAb titer was significantly higher among the eight ICU patients than the 42 non-ICU patients (7280 [95% confidence interval (CI) 1468-36099]) vs (671 [95% CI, 368-1223]). Furthermore, NAb titer increased significantly at earlier infection stages among ICU patients than among non-ICU patients. The median number of days to reach the peak Nab titers after symptoms onset was shorter among the ICU patients (17.6) than that of the non-ICU patients (20.1). Multivariate analysis showed that oxygen requirement and fever during admission were the only clinical factors independently associated with higher NAb titers. Our data suggested that SARS-CoV-2 was unlikely to have silently spread before the COVID-19 emergence in Hong Kong. ICU patients had an accelerated and augmented NAb response compared to non-ICU patients, which was associated with disease severity. Further studies are required to understand the relationship between high NAb response and disease severity. url: https://www.ncbi.nlm.nih.gov/pubmed/32618497/ doi: 10.1080/22221751.2020.1791738 id: cord-263241-qzerj9bs author: Liu, Liu title: Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction date: 2020-08-20 words: 1538.0 sentences: 103.0 pages: flesch: 53.0 cache: ./cache/cord-263241-qzerj9bs.txt txt: ./txt/cord-263241-qzerj9bs.txt summary: title: Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction In this study, the clinical data from hospitalized patients were retrospectively analyzed at their admission to identify if there is any evidence of proximal tubule injury. The patients were diagnosed and classified according to the "Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 4)." [3] Patients with a history of chronic kidney disease (CKD) and with any abnormal urinalysis result in the past 3 months before admission were excluded. This study found that 10.1% of the patients presented with renal glucosuria, 34.2% with mild proteinuria, 25.8% with hyponatremia, and 20.4% with hypouricemia. The presence of renal glucosuria, mild proteinuria, and hyponatremia in patients with COVID-19 indicated the possibility of proximal tubular injury, highlighting the necessity for further investigation. Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction abstract: nan url: https://doi.org/10.1097/cm9.0000000000000945 doi: 10.1097/cm9.0000000000000945 id: cord-032930-ohsh46l2 author: Liu, Priscila Menezes Ferri title: Hepatorenal syndrome in children: a review date: 2020-10-01 words: 7405.0 sentences: 417.0 pages: flesch: 42.0 cache: ./cache/cord-032930-ohsh46l2.txt txt: ./txt/cord-032930-ohsh46l2.txt summary: Hepatorenal syndrome (HRS) occurs in patients with cirrhosis or fulminant hepatic failure and is a kind of pre-renal failure due to intense reduction of kidney perfusion induced by severe hepatic injury. Hepatorenal syndrome occurs in patients with cirrhosis or fulminant hepatic failure and is a kind of pre-renal failure due to intense reduction of kidney perfusion induced by increasingly severe hepatic injury. The persistence of these conditions may cause cardiac dysfunction and decreased kidney function, Legend: SNS, sympathetic nervous system; ADH, antidiuretic hormone; NO, nitric oxide; CO, carbon monoxide; PI 2 , prostaglandin I 2 ; EET, epoxyeicosatrienoic acid; CE, endogenous cannabinoids; Ang I, angiotensin I; Ang II, angiotensin II; Ang-(1-7), angiotensin (1) (2) (3) (4) (5) (6) (7) subunit) in cirrhotic rats as a response to CO stimulation was also reported [16] . abstract: Hepatorenal syndrome (HRS) occurs in patients with cirrhosis or fulminant hepatic failure and is a kind of pre-renal failure due to intense reduction of kidney perfusion induced by severe hepatic injury. While other causes of pre-renal acute kidney injury (AKI) respond to fluid infusion, HRS does not. HRS incidence is 5% in children with chronic liver conditions before liver transplantation. Type 1 HRS is an acute and rapidly progressive form that often develops after a precipitating factor, including gastrointestinal bleeding or spontaneous bacterial peritonitis, while type 2 is considered a slowly progressive form of kidney failure that often occurs spontaneously in chronic ascites settings. HRS pathogenesis is multifactorial. Cirrhosis causes portal hypertension; therefore, stasis and release of vasodilator substances occur in the hepatic vascular bed, leading to vasodilatation of splanchnic arteries and systemic hypotension. Many mechanisms seem to work together to cause this imbalance: splanchnic vasodilatation; vasoactive mediators; hyperdynamic circulation states and subsequent cardiac dysfunction; neuro-hormonal mechanisms; changes in sympathetic nervous system, renin-angiotensin system, and vasopressin. In patients with AKI and cirrhosis, fluid expansion therapy needs to be initiated as soon as possible and nephrotoxic drugs discontinued. Once HRS is diagnosed, pharmacological treatment with vasoconstrictors, mainly terlipressin plus albumin, should be initiated. If there is no response, other options can include surgical venous shunts and kidney replacement therapy. In this regard, extracorporeal liver support can be a bridge for liver transplantation, which remains as the ideal treatment. Further studies are necessary to investigate early biomarkers and alternative treatments for HRS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527294/ doi: 10.1007/s00467-020-04762-6 id: cord-309001-erm705tg author: Liu, Q. title: Laboratory findings and a combined multifactorial approach to predict death in critically ill patients with COVID-19: a retrospective study date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: To describe the laboratory findings of cases of death with coronavirus disease 2019 (COVID-19) and to establish a scoring system for predicting death, we conducted this single-centre, retrospective, observational study including 336 adult patients (≥18 years old) with severe or critically ill COVID-19 admitted in two wards of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, who had definite outcomes (death or discharge) between 1 February 2020 and 13 March 2020. Single variable and multivariable logistic regression analyses were performed to identify mortality-related factors. We combined multiple factors to predict mortality, which was validated by receiver operating characteristic curves. As a result, in a total of 336 patients, 34 (10.1%) patients died during hospitalisation. Through multivariable logistic regression, we found that decreased lymphocyte ratio (Lymr, %) (odds ratio, OR 0.574, P < 0.001), elevated blood urea nitrogen (BUN) (OR 1.513, P = 0.009), and raised D-dimer (DD) (OR 1.334, P = 0.002) at admission were closely related to death. The combined prediction model was developed by these factors with a sensitivity of 100.0% and specificity of 97.2%. In conclusion, decreased Lymr, elevated BUN, and raised DD were found to be in association with death outcomes in critically ill patients with COVID-19. A scoring system was developed to predict the clinical outcome of these patients. url: https://doi.org/10.1017/s0950268820001442 doi: 10.1017/s0950268820001442 id: cord-310676-125o0o7x author: Liu, Qibin title: Prediction of the clinical outcome of COVID-19 patients using T lymphocyte subsets with 340 cases from Wuhan, China: a retrospective cohort study and a web visualization tool date: 2020-04-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background Wuhan, China was the epicenter of the 2019 coronavirus outbreak. As a designated hospital, Wuhan Pulmonary Hospital has received over 700 COVID-19 patients. With the COVID-19 becoming a pandemic all over the world, we aim to share our epidemiological and clinical findings with the global community. Methods In this retrospective cohort study, we studied 340 confirmed COVID-19 patients from Wuhan Pulmonary Hospital, including 310 discharged cases and 30 death cases. We analyzed their demographic, epidemiological, clinical and laboratory data and implemented our findings into an interactive, free access web application. Findings Baseline T lymphocyte Subsets differed significantly between the discharged cases and the death cases in two-sample t-tests: Total T cells (p < 2.2e-16), Helper T cells (p < 2.2e-16), Suppressor T cells (p = 1.8-14), and TH/TS (Helper/Suppressor ratio, p = 0.0066). Multivariate logistic regression model with death or discharge as the outcome resulted in the following significant predictors: age (OR 1.05, p 0.04), underlying disease status (OR 3.42, p 0.02), Helper T cells on the log scale (OR 0.22, p 0.00), and TH/TS on the log scale (OR 4.80, p 0.00). The McFadden pseudo R-squared for the logistic regression model is 0.35, suggesting the model has a fair predictive power. Interpretation While age and underlying diseases are known risk factors for poor prognosis, patients with a less damaged immune system at the time of hospitalization had higher chance of recovery. Close monitoring of the T lymphocyte subsets might provide valuable information of the patients condition change during the treatment process. Our web visualization application can be used as a supplementary tool for the evaluation. url: https://doi.org/10.1101/2020.04.06.20056127 doi: 10.1101/2020.04.06.20056127 id: cord-321983-566pbuic author: Liu, Wei title: Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease date: 2020-02-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Since early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study aims to investigate the factors affecting the progression of pneumonia in COVID-19 patients. Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia. METHODS: Patients tested positive for the COVID-19 based on nucleic acid detection were included in this study. Patients were admitted to 3 tertiary hospitals in Wuhan between December 30, 2019, and January 15, 2020. Individual data, laboratory indices, imaging characteristics, and clinical data were collected, and statistical analysis was performed. Based on clinical typing results, the patients were divided into a progression group or an improvement/stabilization group. Continuous variables were analyzed using independent samples t-test or Mann-Whitney U test. Categorical variables were analyzed using Chi-squared test or Fisher's exact test. Logistic regression analysis was performed to explore the risk factors for disease progression. RESULTS: Seventy-eight patients with COVID-19-induced pneumonia met the inclusion criteria and were included in this study. Efficacy evaluation at 2 weeks after hospitalization indicated that 11 patients (14.1%) had deteriorated, and 67 patients (85.9%) had improved/stabilized. The patients in the progression group were significantly older than those in the disease improvement/stabilization group (66 [51, 70] vs. 37 [32, 41] years, U = 4.932, P = 0.001). The progression group had a significantly higher proportion of patients with a history of smoking than the improvement/stabilization group (27.3% vs. 3.0%, χ(2) = 9.291, P = 0.018). For all the 78 patients, fever was the most common initial symptom, and the maximum body temperature at admission was significantly higher in the progression group than in the improvement/stabilization group (38.2 [37.8, 38.6] vs. 37.5 [37.0, 38.4]°C, U = 2.057, P = 0.027). Moreover, the proportion of patients with respiratory failure (54.5% vs. 20.9%, χ(2) = 5.611, P = 0.028) and respiratory rate (34 [18, 48] vs. 24 [16, 60] breaths/min, U = 4.030, P = 0.004) were significantly higher in the progression group than in the improvement/stabilization group. C-reactive protein was significantly elevated in the progression group compared to the improvement/stabilization group (38.9 [14.3, 64.8] vs. 10.6 [1.9, 33.1] mg/L, U = 1.315, P = 0.024). Albumin was significantly lower in the progression group than in the improvement/stabilization group (36.62 ± 6.60 vs. 41.27 ± 4.55 g/L, U = 2.843, P = 0.006). Patients in the progression group were more likely to receive high-level respiratory support than in the improvement/stabilization group (χ(2) = 16.01, P = 0.001). Multivariate logistic analysis indicated that age (odds ratio [OR], 8.546; 95% confidence interval [CI]: 1.628–44.864; P = 0.011), history of smoking (OR, 14.285; 95% CI: 1.577–25.000; P = 0.018), maximum body temperature at admission (OR, 8.999; 95% CI: 1.036–78.147, P = 0.046), respiratory failure (OR, 8.772, 95% CI: 1.942–40.000; P = 0.016), albumin (OR, 7.353, 95% CI: 1.098–50.000; P = 0.003), and C-reactive protein (OR, 10.530; 95% CI: 1.224−34.701, P = 0.028) were risk factors for disease progression. CONCLUSIONS: Several factors that led to the progression of COVID-19 pneumonia were identified, including age, history of smoking, maximum body temperature at admission, respiratory failure, albumin, C-reactive protein. These results can be used to further enhance the ability of management of COVID-19 pneumonia. url: https://www.ncbi.nlm.nih.gov/pubmed/32118640/ doi: 10.1097/cm9.0000000000000775 id: cord-313529-xm76ae08 author: Liu, Wen-Kuan title: Detection of human bocavirus from children and adults with acute respiratory tract illness in Guangzhou, southern China date: 2011-12-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Human bocavirus (HBoV) is a newly discovered parvovirus associated with acute respiratory tract illness (ARTI) and gastrointestinal illness. Our study is the first to analyze the characteristics of HBoV-positive samples from ARTI patients with a wide age distribution from Guangzhou, southern China. METHODS: Throat swabs (n=2811) were collected and analyzed from children and adults with ARTI over a 13-month period. The HBoV complete genome from a 60 year-old female patient isolate was also determined. RESULTS: HBoV DNA was detected in 65/2811 (2.3%) samples, of which 61/1797 were from children (<18 years old) and 4/1014 from adults (≥18 years old). Seasonal peaks of 4.8% and 7.7% were detected in May and June, respectively. 28 of 65 (43.1%) HBoV-positive samples were co-detected with 11/16 other potential pathogens. Mycoplasma pneumoniae had the highest frequency of 16.9% (11/65). Upper and lower respiratory tract illness were common symptoms, with 19/65 (29.2%) patients diagnosed with pneumonia by chest radiography. All four adult patients had systemic influenza-like symptoms. Phylogenetic analysis of the complete genome revealed a close relationship with other HBoVs, and a more distant relationship with HBoV2 and HBoV3. CONCLUSIONS: HBoV was detected from children and adults with ARTI from Guangzhou, southern China. Elderly people were also susceptive to HBoV. A single lineage of HBoV was detected among a wide age distribution of patients with ARTI. url: https://doi.org/10.1186/1471-2334-11-345 doi: 10.1186/1471-2334-11-345 id: cord-329766-9bwdb6o2 author: Liu, Xiaofan title: Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance date: 2020-06-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 is “public enemy number one” and has placed an enormous burden on health authorities across the world. Given the wide clinical spectrum of COVID-19, understanding the factors that can predict disease severity will be essential since this will help frontline clinical staff to stratify patients with increased confidence. To investigate the diagnostic value of the temporal radiographic changes, and the relationship to disease severity and viral clearance in COVID-19 patients. In this retrospective cohort study, we included 99 patients admitted to the Renmin Hospital of Wuhan University, with laboratory confirmed moderate or severe COVID-19. Temporal radiographic changes and viral clearance were explored using appropriate statistical methods. Radiographic features from HRCT scans included ground-glass opacity, consolidation, air bronchogram, nodular opacities and pleural effusion. The HRCT scores (peak) during disease course in COVID-19 patients with severe pneumonia (median: 24.5) were higher compared to those with pneumonia (median: 10) (p = 3.56 × 10 (−12)), with more frequency of consolidation (p = 0.025) and air bronchogram (p = 7.50 × 10(−6)). The median values of days when the peak HRCT scores were reached in pneumonia or severe pneumonia patients were 12 vs. 14, respectively (p = 0.048). Log-rank test and Spearman’s Rank-Order correlation suggested temporal radiographic changes as a valuable predictor for viral clearance. In addition, follow up CT scans from 11 pneumonia patients showed full recovery. Given the values of HRCT scores for both disease severity and viral clearance, a standardised HRCT score system for COVID-19 is highly demanded. url: https://www.ncbi.nlm.nih.gov/pubmed/32581324/ doi: 10.1038/s41598-020-66895-w id: cord-353484-q7d0ysbo author: Liu, Xue title: COVID-19: Progress in diagnostics, therapy and vaccination date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently become a pandemic. As the sudden emergence and rapid spread of SARS-CoV-2 is endangering global health and the economy, the development of strategies to contain the virus's spread are urgently needed. At present, various diagnostic kits to test for SARS-CoV-2 are available for use to initiate appropriate treatment faster and to limit further spread of the virus. Several drugs have demonstrated in vitro activity against SARS-CoV-2 or potential clinical benefits. In addition, institutions and companies worldwide are working tirelessly to develop treatments and vaccines against COVID-19. However, no drug or vaccine has yet been specifically approved for COVID-19. Given the urgency of the outbreak, we focus here on recent advances in the diagnostics, treatment, and vaccine development for SARS-CoV-2 infection, helping to guide strategies to address the current COVID-19 pandemic. url: https://doi.org/10.7150/thno.47987 doi: 10.7150/thno.47987 id: cord-302800-852w35od author: Liu, Xuebing title: Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China date: 2020-04-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Since the outbreak of COVID-19, no data have been available for hospitalised psychiatric patients who are suspected to have COVID-19. We performed a comprehensive investigation of the clinical features of hospitalised patients with schizophrenia with or without suspected COVID-19 in Hubei Province, China. AIM: To explore the clinical characteristics of hospitalised patients with schizophrenia with suspected COVID-19 in Hubei Province, China. METHODS: 21 hospitalised patients with schizophrenia with suspected COVID-19 (COVID-19 suspected group) in the isolation ward of a mental health hospital in Wuhan and 30 hospitalised patients with schizophrenia (clean group) in the general ward of another mental health hospital in Yichang were recruited. We retrospectively reviewed their clinical characteristics, laboratory findings and chest CT results before 21 February 2020. We also compared the emotional and mental symptoms between the two groups. RESULTS: Medical records revealed that 21 COVID-19 suspected patients were transferred to the isolation ward between 30 January 2020 and 15 February 2020. The mean age (SD) of COVID-19 suspected patients was 43.1 (2.6). 12 (57.1%) patients showed abnormalities on chest CT before onset of respiratory symptoms. 14 (66.7%) patients had psychiatric medications adjustment after detection of abnormal chest CT findings. By 21 February, one patient was confirmed to have COVID-19. Even though the remaining 20 (95.2%) were negative for at least two reverse transcription PCR tests, 11 (52.4%) patients met the diagnostic criteria for clinically confirmed cases. Compared with patients in the clean group, patients in the suspected COVID-19 group showed significantly higher stress, depression and anxiety levels and poorer sleep quality. CONCLUSION: Setting up an independent isolation ward for hospitalised psychiatric patients who are suspected to have symptoms of COVID-19 helped control the spread of the epidemic. Patients with schizophrenia suspected to have COVID-19 showed increased stress and mood and sleep disturbances, which should be appropriately managed. url: https://www.ncbi.nlm.nih.gov/pubmed/32420523/ doi: 10.1136/gpsych-2020-100222 id: cord-255805-wlr8nod3 author: Liu, Yan title: Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19: A case report date: 2020-10-16 words: 3830.0 sentences: 202.0 pages: flesch: 43.0 cache: ./cache/cord-255805-wlr8nod3.txt txt: ./txt/cord-255805-wlr8nod3.txt summary: The clinical data and the evolution of the disease process of a critical novel coronavirus pneumonia patient who has been successfully treated by mechanical ventilation through tracheal intubation in the intensive care isolation ward of Taihe Hospital in Shiyan City (Hubei Medical College Affiliated Hospital) were analyzed and summarized, to provide a clinical reference for the diagnosis and treatment of critical COVID-19 patients. On March 22, the patient again performed bedside bronchoscopy to clear the airway secretions and successfully removed the tracheal intubation, given nasal high-flow oxygen therapy and continued to anti-infection, airway management, nutritional support, immunity enhancement, and respiratory function exercises treatment. [6] [7] [8] In this case, as the patients condition developed and progressed, the patients diagnosis, which was based on imaging, blood gas analysis and other tests, had been considered secondary bronchial fistula, bacterial lung infection, and acute respiratory distress syndrome (ARDS): persistent carbon dioxide retention and hypercarbonemia after mechanical ventilation by endotracheal intubation. abstract: RATIONALE: The new coronavirus pneumonia Corona Virus Disease 2019 (COVID-19) has become a global pandemic. Patients with critically COVID-19 usually require invasive respiratory support, and the airway management is particularly important and the prognosis is poor. PATIENT CONCERNS: A 64-year-old man with an anastomotic fistula after radical treatment of esophageal cancer and right-side encapsulated pyopneumothorax was admitted with cough and dyspnea. DIAGNOSIS: The patient was diagnosed with novel coronavirus pneumonia and right-side encapsulated pyopneumothorax by pharyngeal swab nucleic acid test in combination with chest computed tomography (CT). INTERVENTIONS: The patient was treated with antibiotics, antiviral and antibacterial medications, respiratory support, expectorant nebulization, and nutritional support. But he expressed progressive deterioration. Endotracheal intubation and mechanical ventilation were performed since the onset of the type - respiratory failure on the 13th day of admission. The patient had persistent refractory hypercapnia after mechanical ventilation. Based on the treatment mentioned above, combined with repeated bronchoalveolar lavage by using N-acetylcysteine (NAC) inhalation solution, the patients refractory hypercapnia was gradually improved. OUTCOMES: The patient was cured and discharged after being given the mechanical ventilation for 26 days as well as 46 days of hospitalization, currently is surviving well. LESSONS: : Patients with severe conditions of novel coronavirus pneumonia often encounter bacterial infection in their later illness-stages. They may suffer respiratory failure and refractory hypercapnia that is difficult to improve due to excessive mucus secretion leading to small airway obstruction. This study provided a new insight on the proper treatment severe COVID-19 patients. The use of reasonable antibiotics and symptomatic respiratory support and other treatment, timely artificial airway and repeated bronchoalveolar NAC inhalation solution lavage, expectorant and other airway management are essential for such patients. url: https://doi.org/10.1097/md.0000000000022577 doi: 10.1097/md.0000000000022577 id: cord-274282-hvx5m2bx author: Liu, Yang title: Association between ages and clinical characteristics and outcomes of coronavirus disease 2019 date: 2020-04-27 words: 1540.0 sentences: 86.0 pages: flesch: 53.0 cache: ./cache/cord-274282-hvx5m2bx.txt txt: ./txt/cord-274282-hvx5m2bx.txt summary: This study showed that clinical features and prognosis of the disease vary among patients of different ages and a thorough assessment of age may help clinicians worldwide to establish risk stratification for all COVID-19 patients. However, the ages related clinical characteristics, diseases courses and outcomes other than death in COVID-19 patients remain unclear. A unified observation endpoint date was set (March 7, 2020) in our study, primary outcome of the disease course and second outcome of respiratory failure rate for all COVID-19 patients in both groups were compared. In this study, we demonstrated that the clinical characteristics and outcomes of 221 COVID-19 patients were closely related to the different ages. In conclusion, the clinical features and prognosis of the disease vary among patients of different ages and a thorough assessment of age may help clinicians worldwide to establish risk stratification for all COVID-19 patients. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China abstract: Age significantly determined the clinical features and prognosis of the disease. The prognosis was worse in patients older than 60 years, calling for clinicians to pay more attention to patients on this special age. https://bit.ly/34DTI05 url: https://www.ncbi.nlm.nih.gov/pubmed/32312864/ doi: 10.1183/13993003.01112-2020 id: cord-320930-9yiu0080 author: Liu, Zeming title: Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. Results: The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%, p = 0.001). However, patients with and without diabetes showed no difference in the follow-up period (p = 0.993). The mortality rate in patients with or without diabetes was 2.9% (n = 4) and 1.1% (n = 9), respectively (p = 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all p > 0.05). Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32760350/ doi: 10.3389/fendo.2020.00478 id: cord-352544-7b6btzrx author: Liu, Zhelong title: The association of diabetes and the prognosis of COVID-19 patients: a retrospective study date: 2020-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Aims This study evaluated the impact of previous glycemic control and in-hospital use of antidiabetic/antihypertensive drugs on the prognosis of COVID-19 patients with diabetes. Methods In this retrospective cohort study, consecutive inpatients with laboratory confirmed COVID-19 were enrolled from Tongji Hospital (Wuhan, China). Patients without diabetes were matched to those with diabetes based on age, sex, and comorbidities. All patients were followed up to a clinical endpoint (discharge, worsening including transferring to ICU or immediate death). Data and outcomes were extracted from medical records and analyzed. Results 64 patients with pre-existing diabetes were included in this study, with 128 matched patients without diabetes included as a control group. Patients with diabetes had a higher rate of worsening (18.8% versus 7.8%, p=0.025). Multivariable regression showed increased odds of worsening associated with previous glycemic control reflected by HbA1c (odds ratio 3.29, 95% CI 1.19-9.13, p=0.022) and receiver-operating characteristics (ROC) curve identified HbA1c of 8.6% (70 mmol/mol) as the optimal cut-off value. Univariate analysis demonstrated the in-hospital use of antidiabetic/antihypertensive drugs were not associated with a higher risk of worsening. Conclusions COVID-19 patients with diabetes had a higher risk of worsening, especially those with poorly-controlled HbA1c, with an optimal cut-off value of 8.6%. The in-hospital use of antidiabetic/antihypertensive drugs were not associated with increased odds of worsening in patients with diabetes. url: https://api.elsevier.com/content/article/pii/S0168822720306392 doi: 10.1016/j.diabres.2020.108386 id: cord-316764-ps89rxuy author: Liu, Zheng title: At the center of the COVID‐19 pandemic: Lessons learned for otolaryngology‐head and neck surgery in China date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1002/alr.22585 doi: 10.1002/alr.22585 id: cord-342139-t2tukk0z author: Livingston, Gill title: Prevalence, management, and outcomes of SARS-CoV-2 infections in older people and those with dementia in mental health wards in London, UK: a retrospective observational study date: 2020-10-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: People living in group situations or with dementia are more vulnerable to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older people and those with multimorbidity have higher mortality if they become infected than the general population. However, no systematic study exists of COVID-19-related outcomes in older inpatients in psychiatric units, who comprise people from these high-risk groups. We aimed to describe the period prevalence, demographics, symptoms (and asymptomatic cases), management, and survival outcomes of COVID-19 in the older inpatient psychiatric population and people with young-onset dementia in five National Health Service Trusts in London, UK, from March 1 to April 30, 2020. METHODS: In this retrospective observational study, we collected demographic data, mental health diagnoses, clinical diagnosis of COVID-19, symptoms, management, and COVID-19-related outcome data of inpatients aged 65 years or older or with dementia who were already inpatients or admitted as inpatients to five London mental health Trusts between March 1 and April 30, 2020, and information about available COVID-19-related resources (ie, testing and personal protective equipment). Patients were determined to have COVID-19 if they had a positive SARS-CoV-2 PCR test, or had relevant symptoms indicative of COVID-19, as determined by their treating physician. We calculated period prevalence of COVID-19 and analysed patients’ characteristics, treatments, and outcomes. FINDINGS: Of 344 inpatients, 131 (38%) were diagnosed with COVID-19 during the study period (period prevalence 38% [95% CI 33–43]). The mean age of patients who had COVID-19 was 75·3 years (SD 8·2); 68 (52%) were women and 47 (36%) from ethnic minority groups. 16 (12%) of 131 patients were asymptomatic and 121 (92%) had one or more disease-related comorbidity. 108 (82%) patients were compulsorily detained. 74 (56%) patients had dementia, of whom 13 (18%) had young-onset dementia. On average, sites received COVID-19 testing kits 4·5 days after the first clinical COVID-19 presentation. 19 (15%) patients diagnosed with COVID-19 died during the study period, and their deaths were determined to be COVID-19 related. INTERPRETATION: Patients in psychiatric inpatient settings who were admitted without known SARS-CoV-2 infection had a high risk of infection with SARS-CoV-2 compared with those in the community and had a higher proportion of deaths from COVID-19 than in the community. Implementation of the long-standing policy of parity of esteem for mental health and planning for future COVID-19 waves in psychiatric hospitals is urgent. FUNDING: None. url: https://api.elsevier.com/content/article/pii/S221503662030434X doi: 10.1016/s2215-0366(20)30434-x id: cord-011284-u4qmvz3c author: Livingston, Nicholas A. title: Addressing Diversity in PTSD Treatment: Clinical Considerations and Guidance for the Treatment of PTSD in LGBTQ Populations date: 2020-03-16 words: 5249.0 sentences: 207.0 pages: flesch: 28.0 cache: ./cache/cord-011284-u4qmvz3c.txt txt: ./txt/cord-011284-u4qmvz3c.txt summary: However, evaluations of these interventions have failed to examine the role of LGBTQ identities in recovery from trauma, and existing PTSD treatments do not account for ongoing threat to safety or the pervasive minority stress experienced by LGBTQ patients. To begin the review of current best-practice interventions for PTSD, it is important to note that gold-standard PTSD treatments, such as PE and CPT, were not developed for non-criterion A trauma, and that debate continues regarding the appropriateness or sufficiency of these treatments in addressing the range of clinically significant experiences faced by many LGBTQ individuals (e.g., discrimination [29••] ). Given the pervasive nature of stress, stigma, and discrimination against LGBTQ people, and the concomitant high rates of trauma exposure, it is critical for health care providers to ensure cultural awareness, sensitivity, and responsiveness to the experiences and healthcare needs of this patient population. In this paper, we provided an overview of the key issues with respect to trauma, PTSD, minority stress, and evidence-based treatment for LGBTQ patients with which any health care provider should be aware. abstract: PURPOSE OF REVIEW: Trauma exposure is widespread but is especially common among lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals. LGBTQ individuals also experience higher rates of discrimination, victimization, and minority stress which can complicate posttraumatic stress disorder (PTSD) treatment but also represent independent intervention targets. In this review, we highlight existing evidence-based practices, current limitations, and provide recommendations for care in the absence of established guidelines for treatment PTSD among LGBTQ patients. RECENT FINDINGS: Trauma-focused therapies (e.g., CPT, PE) and medications (e.g., SSRIs, SNRIs) have shown benefit for people with PTSD. However, evaluations of these interventions have failed to examine the role of LGBTQ identities in recovery from trauma, and existing PTSD treatments do not account for ongoing threat to safety or the pervasive minority stress experienced by LGBTQ patients. In addition, many LGBTQ patients report negative experiences with healthcare, necessitating increased education and cultural awareness on the part of clinicians to provide patient-centered care and, potentially, corrective mental health treatment experiences. SUMMARY: Providers should routinely assess trauma exposure, PTSD, and minority stress among LGBTQ patients. We provide assessment and screening recommendations, outline current evidence-based treatments, and suggest strategies for integrating existing treatments to treat PTSD among LGBTQ patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223966/ doi: 10.1007/s40501-020-00204-0 id: cord-326643-obfvi3ms author: Lo Giudice, Roberto title: The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) in Dentistry. Management of Biological Risk in Dental Practice date: 2020-04-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, and the etiological agent of Coronavirus Disease-2019 (COVID-19). This infection spreads mainly through direct contact with Flügge micro droplets or core droplets that remain suspended as aerosol. Moreover, it has been reported that infected subjects, both with and without clinical signs of COVID-19, can transmit the virus. Since the infection typically enters through mouth, nose, and eyes, dentistry is one of the medical practices at highest risk of infection due to the frequent production of aerosol and the constant presence of saliva. The World Health Organization (WHO) has suggested that only emergency/urgent procedures should be performed during the coronavirus outbreak. Considering the virus’ route of transmission, a specific protocol should be applied to reduce the risk of infection in addition to measures that prevent the spread of infection from a patient to another person or medical tools and equipment (cross-infection). This protocol should be implemented by modifying both patient management and clinical practice, introducing particular devices and organizational practices. This paper aims to discuss and suggest the most appropriate procedures in every aspect of dental practice to reduce infection risk. url: https://doi.org/10.3390/ijerph17093067 doi: 10.3390/ijerph17093067 id: cord-252981-hywvmdjb author: Lockey, Stephen D. title: What’s Important: What Is Our Role in the COVID-19 Pandemic? date: 2020-04-10 words: 907.0 sentences: 45.0 pages: flesch: 56.0 cache: ./cache/cord-252981-hywvmdjb.txt txt: ./txt/cord-252981-hywvmdjb.txt summary: The public health campaign encouraging social distancing must also provide tips for remaining safe from physical harm. The public must consider 2 important consequences of a trip to the emergency department in today''s climate in addition to the harm created by the injury itself: (1) as the virus spreads, they are putting themselves at risk of exposure as providers triage and care for those with the disease; and (2) the time and resources it takes to care for injuries will create additional strain on our hospital system. With more than 25,000 orthopaedic surgeons in practice in the United States 1 caring for patients of all ages and demographics, there are specific steps we can take in order to help the public prevent hospital visits and take extra precautions to remain safe while social distancing. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32282413/ doi: 10.2106/jbjs.20.00444 id: cord-006523-zxn4oqly author: Lodha, Rakesh title: Nosocomial infections in pediatric intensive care units date: 2001 words: 5227.0 sentences: 340.0 pages: flesch: 37.0 cache: ./cache/cord-006523-zxn4oqly.txt txt: ./txt/cord-006523-zxn4oqly.txt summary: The common nosocomial infections in PICU are bloodstream infections (20–30% of all infections), lower respiratory tract infections (20–35%), and urinary tract infections (15–20%); there may be some differences in their incidence in different PICUs. The risk of nosocomial infections depends on the host characteristics, the number of interventions, invasive procedures, asepsis of techniques, the duration of stay in the PICU and inappropriate use of antimicrobials. 3 In the same study, it was observed that 91% of all nosocomial bloodstream infections occurred in children with central venous lines, 95% of nosocomial pneumonias occurred in those on mechanical ventilation and 77% of UTIs in children with urinary catheters. Transtracheal aspiration in non-intubated patients, percutaneous thin needle lung aspirations, bronchoalveolar lavage (bronchoscopic or blind), and protected bronchoscopic samples of the lower airways have all been suggested as methods for diagnosis, where contamination of lower respiratory secretions with upper airway flora is prevent-ed29~~ In the absence of gold standard criteria for the diagnosis of ventilator-associated pneumonia, quantitative cultures and microscopic examination of the lower respiratory tract secretions are the diagnostic tests of choice. abstract: Nosocomial infections are a significant problem in pediatric intensive care units. While Indian estimates are not available, western PICUs report incidence of 6–8%. The common nosocomial infections in PICU are bloodstream infections (20–30% of all infections), lower respiratory tract infections (20–35%), and urinary tract infections (15–20%); there may be some differences in their incidence in different PICUs. The risk of nosocomial infections depends on the host characteristics, the number of interventions, invasive procedures, asepsis of techniques, the duration of stay in the PICU and inappropriate use of antimicrobials. Most often the child had endogenous flora, which may be altered because of hospitalization, are responsible for the infections. The common pathogens involved areStaphylococcus aureus, coagulase negativestaphylococci, E. coli Pseudomonas aeruginosa, Klebsiella, enterococci, andCandida. Nosocomial pneumonias predominantly occur in mechanically ventilated children. There is no consensus on the optimal approach for their diagnosis. Bloodstream infections are usually attributable to the use of central venous lines; use of TPN and use of femoral site for insertion increase the risk. Urinary tract infections occur mostly after catheterization and can lead to secondary bacteremia. The diagnostic criteria have been discussed in the review. With proper preventive strategies, the nosocomial infection rates can be reduced by up to 50%; handwashing, judicious use of interventions, and proper asepsis during procedures remain the most important practices. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101966/ doi: 10.1007/bf02722358 id: cord-272585-346ef6qy author: Lombardi, JM title: Addressing a National Crisis: The Spine Hospital and Department''s Response to the COVID-19 Pandemic in New York City date: 2020-05-31 words: 5078.0 sentences: 262.0 pages: flesch: 51.0 cache: ./cache/cord-272585-346ef6qy.txt txt: ./txt/cord-272585-346ef6qy.txt summary: title: Addressing a National Crisis: The Spine Hospital and Department''s Response to the COVID-19 Pandemic in New York City As peak infections spread across the United States, we hope this article will serve as a resource for other spine departments on how to manage patient care and healthcare worker deployment during the COVID-19 crisis. Our institution has been on the forefront of the COVID-19 pandemic, as we treated "patient zero" in New York City, who presented to our Emergency Department (ED) on February 28 th . Published data by healthcare providers in Asia and Europe demonstrated that the most substantial threat to COVID-19 patient morbidity and mortality was the lack of adequate critical care resources including intensive care unit (ICU) beds and respiratory support [8] [9] . It is vital to note that although redeployment was an important initiative to our department during this time of crisis, our primary concern was to maintain an adequate workforce to meet all orthopaedic surgical demands at our institution. abstract: In a very brief period, the COVID-19 pandemic has swept across the planet leaving governments, societies and healthcare systems unprepared and under-resourced. New York City now represents the global viral epicenter with roughly one third of all mortalities in the United States. To date, our hospital has treated thousands of COVID-19 positive patients and sits at the forefront of the United States response to this pandemic. The goal of this paper is to share the lessons learned by our spine division during a crisis when hospital resources and personnel are stretched thin. Such experiences include management of elective and emergent cases, outpatient clinics, physician redeployment and general health and wellness. As peak infections spread across the United States, we hope this article will serve as a resource for other spine departments on how to manage patient care and healthcare worker deployment during the COVID-19 crisis. url: https://api.elsevier.com/content/article/pii/S1529943020307609 doi: 10.1016/j.spinee.2020.05.539 id: cord-333470-0a0i6vjn author: Lombe, Dorothy C title: Zambia’s National Cancer Centre response to the COVID-19 pandemic—an opportunity for improved care date: 2020-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has overwhelmed health systems around the globe even in countries with strong economies. This is of particular concern for nations with weaker health systems. This article reports the response of a comprehensive cancer centre in a lower-middle income country to prevent COVID-19 transmission and how the implementation of pragmatic strategies have served as a springboard to improve cancer services beyond the COVID-19 pandemic. The strategies included establishment of a local taskforce, increased education and facilitation of good hygiene practices, staff training, patient triaging, improved patient scheduling, remote review of patients and establishing a virtual platform for meetings. url: https://www.ncbi.nlm.nih.gov/pubmed/32565904/ doi: 10.3332/ecancer.2020.1051 id: cord-316987-3nhqx2qn author: London, Viktoriya title: Caring for Pregnant Patients with COVID-19: Practical Tips Getting from Policy to Practice date: 2020-05-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Novel coronavirus disease 2019 (COVID-19) is a pandemic with most American cases in New York. As an institution residing in a high-prevalence zip code, with over 8,000 births annually, we have cared for over 80 COVID-19-infected pregnant women, and have encountered many challenges in applying new national standards for care. In this article, we review how to change outpatient and inpatient practices, develop, and disseminate new hospital protocols, and we highlight the psychosocial challenges for pregnant patients and their providers. Key Points: Novel coronavirus disease 2019 (COVID-19) information rapidly changes. Multidisciplinary communication is key. This study addresses psychosocial challenges. url: https://www.ncbi.nlm.nih.gov/pubmed/32380564/ doi: 10.1055/s-0040-1710539 id: cord-029991-0sy417j0 author: Longhini, Federico title: Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study date: 2020-08-03 words: 4621.0 sentences: 239.0 pages: flesch: 39.0 cache: ./cache/cord-029991-0sy417j0.txt txt: ./txt/cord-029991-0sy417j0.txt summary: BACKGROUND: Besides airway suctioning, patients undergoing invasive mechanical ventilation (iMV) benefit of different combinations of chest physiotherapy techniques, to improve mucus removal. The presence of an endotracheal tube impairs the bronchial mucus velocity transport in anaesthetized dogs [2] ; in critically ill patients undergoing invasive mechanical ventilation (iMV), it seriously impairs cough reflex and mucociliary escalator function [3, 4] , promoting the accumulation of tracheobronchial secretions, leading to sequestration and densification of secretions in the lower airways and increasing the risk of pneumonia [5] and lung atelectasis [6] . The aim of this pilot randomized physiological study is assessing the effects of HFCWO on lung aeration and ventilation distribution, as assessed by EIT, in normosecretive and hypersecretive mechanically ventilated patients. Our study shows that chest physiotherapy by HFCWO may improve lung aeration of hypersecretive mechanically ventilated patients, without affecting gas exchange. abstract: BACKGROUND: Besides airway suctioning, patients undergoing invasive mechanical ventilation (iMV) benefit of different combinations of chest physiotherapy techniques, to improve mucus removal. To date, little is known about the clearance effects of oscillating devices on patients with acute respiratory failure undergoing iMV. This study aimed to assess (1) the effects of high-frequency chest wall oscillation (HFCWO) on lung aeration and ventilation distribution, as assessed by electrical impedance tomography (EIT), and (2) the effect of the association of HFCWO with recruitment manoeuvres (RM). METHODS: Sixty critically ill patients, 30 classified as normosecretive and 30 as hypersecretive, who received ≥ 48 h of iMV, underwent HFCWO; patients from both subgroups were randomized to receive RM or not, according to two separated randomization sequences. We therefore obtained four arms of 15 patients each. After baseline record (T0), HFCWO was applied for 10 min. At the end of the treatment (T1) or after 1 (T2) and 3 h (T3), EIT data were recorded. At the beginning of each step, closed tracheobronchial suctioning was performed. In the RM subgroup, tracheobronchial suctioning was followed by application of 30 cmH(2)O to the patient’s airway for 30 s. At each step, we assessed the change in end-expiratory lung impedance (ΔEELI) and in tidal impedance variation (ΔTIV), and the center of gravity (COG) through EIT. We also analysed arterial blood gases (ABGs). RESULTS: ΔTIV and COG did not differ between normosecretive and hypersecretive patients. Compared to T0, ΔEELI significantly increased in hypersecretive patients at T2 and T3, irrespective of the RM; on the contrary, no differences were observed in normosecretive patients. No differences of ABGs were recorded. CONCLUSIONS: In hypersecretive patients, HFCWO significantly improved aeration of the dorsal lung region, without affecting ABGs. The application of RM did not provide any further improvements. TRIAL REGISTRATION: Prospectively registered at the Australian New Zealand Clinical Trial Registry (www.anzctr.org.au; number of registration: ACTRN12615001257550; date of registration: 17th November 2015). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396943/ doi: 10.1186/s13054-020-03198-6 id: cord-282589-xof56j98 author: Lopes, M. I. F. title: Beneficial effects of colchicine for moderate to severe COVID-19: an interim analysis of a randomized, double-blinded, placebo controlled clinical trial date: 2020-08-11 words: 3972.0 sentences: 200.0 pages: flesch: 53.0 cache: ./cache/cord-282589-xof56j98.txt txt: ./txt/cord-282589-xof56j98.txt summary: We present the interim analysis of a single-center randomized, double-blinded, placebo controlled clinical trial of colchicine for the treatment of moderate to severe COVID-19, with 38 patients allocated 1:1 from April 11 to July 06, 2020. We conducted a randomized, double-blinded, placebo controlled clinical trial to evaluate the use of colchicine for the treatment of hospitalized patients with moderate to severe COVID-19. As secondary endpoints we assessed clinical and laboratory parameters: measures of serum CRP, serum LDH and relation neutrophil to lymphocyte of peripheral blood samples from day zero to day 7; the number, type, and severity of adverse events; frequency of interruption of the study protocol due to adverse events; and frequency of QT interval above 450 ms. Patients who received colchicine in this randomized, double-blinded, placebo controlled clinical trial presented better evolution in terms of the need for supplemental oxygen and the length of hospitalization. abstract: Introduction. Neutrophilia and high levels of proinflammatory cytokines and other mediators of inflammation are common finds in patients with severe acute respiratory syndrome due to COVID-19. By its action on leukocytes, we propose colchicine as an intervention worthy of being tested. Objective. To evaluate whether the addition of colchicine to standard treatment for COVID-19 results in better outcomes. Methods. We present the interim analysis of a single-center randomized, double-blinded, placebo controlled clinical trial of colchicine for the treatment of moderate to severe COVID-19, with 38 patients allocated 1:1 from April 11 to July 06, 2020. Colchicine regimen was 0.5 mg thrice daily for 5 days, then 0.5 mg twice daily for 5 days. The first dose was 1.0 mg whether body weight was [≥] 80 kg. Endpoints. The primary endpoints were the need for supplemental oxygen; time of hospitalization; need for admission and length of stay in intensive care units; and death rate and causes of mortality. As secondary endpoints, we assessed: serum C-reactive protein, serum Lactate dehydrogenase and relation neutrophil to lymphocyte of peripheral blood samples from day zero to day 7; the number, type, and severity of adverse events; frequency of interruption of the study protocol due to adverse events; and frequency of QT interval above 450 ms. Results. Thirty-five patients (18 for Placebo and 17 for Colchicine) completed the study. Both groups were comparable in terms of demographic, clinical and laboratory data at baseline. Median (and interquartile range) time of need for supplemental oxygen was 3.0 (1.5-6.5) days for the Colchicine group and 7.0 (3.0-8.5) days for Placebo group (p = 0.02). Median (IQR) time of hospitalization was 6.0 (4.0-8.5) days for the Colchicine group and 8.5 (5.5-11.0) days for Placebo group (p = 0.03). At day 2, 53% vs 83% of patients maintained the need for supplemental oxygen, while at day 7 the values were 6% vs 39%, in the Colchicine and Placebo groups, respectively (log rank; p = 0.01). Hospitalization was maintained for 53% vs 78% of patients at day 5 and 6% vs 17% at day 10, for the Colchicine and Placebo groups, respectively (log rank; p = 0.01). One patient per group needed admission to ICU. No recruited patient died. At day 4, patients of Colchicine group presented significant reduction of serum C-reactive protein compared to baseline (p < 0.001). The majority of adverse events were mild and did not lead to patient withdrawal. Diarrhea was more frequent in the Colchicine group (p = 0.17). Cardiac adverse events were absent. Discussion. The use of colchicine reduced the length of supplemental oxygen therapy and the length of hospitalization. Clinical improvement was in parallel with a reduction on serum levels of C-reactive protein. The drug was safe and well tolerated. Colchicine may be considered a beneficial and not expensive option for COVID-19 treatment. Clinical trials with larger numbers of patients should be conducted to further evaluate the efficacy and safety of colchicine as an adjunctive therapy for hospitalized patients with moderate to severe COVID-19. url: http://medrxiv.org/cgi/content/short/2020.08.06.20169573v1?rss=1 doi: 10.1101/2020.08.06.20169573 id: cord-266463-ci0g1dno author: Lopes, Renato D. title: Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-05-13 words: 5179.0 sentences: 280.0 pages: flesch: 47.0 cache: ./cache/cord-266463-ci0g1dno.txt txt: ./txt/cord-266463-ci0g1dno.txt summary: title: Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Secondary outcomes include progression of COVID-19 disease, all-cause mortality, death from vascular causes, myocardial infarction, stroke, transient ischemic attack, new or worsening heart failure, myocarditis, pericarditis, arrhythmias, thromboembolic events, hypertensive crisis, respiratory failure, hemodynamic decompensation, sepsis, renal failure, troponin, B-type natriuretic peptide, N-terminal-pro hormone and D-dimer levels. The secondary objectives are to compare the impact of continued use versus discontinuation of reninangiotensin system inhibition on COVID-19 disease severity, all-cause mortality, cardiovascular death, acute myocardial infarction, new or worsening heart failure, hypertensive crisis, transient ischemic attack, and stroke at 30 days. Patients ≥18 years of age with a confirmed diagnosis of COVID-19 who are on chronic renin-angiotensin system inhibitor (ACEI/ARB) therapy will be assessed for the BRACE CORONA trial. abstract: BACKGROUND: Angiotensin-converting enzyme-2 (ACE2) may increase due to upregulation in patients using angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB). Because renin-angiotensin system blockers increase levels of ACE2, a protein that facilitates coronavirus entry into cells, there is concern that these drugs could increase the risk of developing a severe and fatal form of COVID-19. The impact of discontinuing ACEI and ARBs in patients with COVID-19 remains uncertain. DESIGN BRACE CORONA is a pragmatic, multicenter, randomized, phase IV, clinical trial that aims to enroll around 500 participants at 32 sites in Brazil. Participants will be identified from an ongoing national registry of suspected and confirmed cases of COVID-19. Eligible patients using renin-angiotensin system blockers (ACEI/ARBs) with a confirmed diagnosis of COVID-19 will be randomized to a strategy of continued ACEI/ARB treatment versus temporary discontinuation for 30 days. The primary outcome is the median days alive and out of the hospital at 30 days. Secondary outcomes include progression of COVID-19 disease, all-cause mortality, death from vascular causes, myocardial infarction, stroke, transient ischemic attack, new or worsening heart failure, myocarditis, pericarditis, arrhythmias, thromboembolic events, hypertensive crisis, respiratory failure, hemodynamic decompensation, sepsis, renal failure, troponin, B-type natriuretic peptide, N-terminal-pro hormone and D-dimer levels. SUMMARY: BRACE CORONA will evaluate whether the strategy of continued ACEI/ARB therapy compared with temporary discontinuation of these drugs impacts clinical outcomes among patients with COVID-19. url: https://doi.org/10.1016/j.ahj.2020.05.002 doi: 10.1016/j.ahj.2020.05.002 id: cord-287468-e5h4tmy6 author: Lopez, Alexandre title: Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results date: 2020-08-08 words: 1978.0 sentences: 124.0 pages: flesch: 52.0 cache: ./cache/cord-287468-e5h4tmy6.txt txt: ./txt/cord-287468-e5h4tmy6.txt summary: The primary objective of our study was to assess the effects of hydroxychloroquine according to its plasma concentration in ICU patients. reported that hydroxychloroquine and azithromycin was associated with viral load reduction in nasopharyngeal samples in patients after six days of treatment [6] . The Surviving Sepsis Campaign guidelines on the management of Covid-19 patients concluded there was insufficient evidence to recommend the use of antiviral drugs and hydroxychloroquine in ICU patients [7] . Confirmed Covid-19 patients with acute respiratory failure were included in the study if they completed the criteria: i) age of 18 or older and; ii) polymerase chain reaction (PCR) documented SARS-CoV-2 in nasopharyngeal samples upon ICU admission. In conclusion, our results showed that there was no association between the plasma concentration of hydroxychloroquine and the viral and clinical evolution of ICU patients admitted for Covid-19. abstract: During the Covid-19 pandemic, a large number of intensive care unit (ICU) patients received hydroxychloroquine. The primary objective of our study was to assess the effects of hydroxychloroquine according to its plasma concentration in ICU patients. To this purpose, a single-center retrospective study was performed from March to April 2020 in an ICU of a university hospital. All patients admitted to our ICU with a confirmed Covid-19 pneumonia and treated by hydroxychloroquine were included. We compared 17 patients in whom the hydroxychloroquine plasma concentration was in the therapeutic target (on-target) and 12 patients in whom the plasma concentration was below the target (off-target). The follow-up of patients was 15 days. No association was found between hydroxychloroquine plasma concentration and viral load evolution (p = 0.77). There was no significant difference between the two groups for the duration of mechanical ventilation, length of ICU stay, in-hospital mortality, and 15-days mortality. This finding suggests that hydroxychloroquine administration for Covid-19 patients hospitalized in ICU is not associated with improved outcomes. These results need confirmation by larger multicenter studies. url: https://doi.org/10.1016/j.ijantimicag.2020.106136 doi: 10.1016/j.ijantimicag.2020.106136 id: cord-328147-61gtx2h2 author: Lopez-Mendez, Ivan title: Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19) date: 2020-10-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION AND OBJECTIVES: Liver function tests (LFT) abnormalities are reported in up to 50% of COVID-19 patients, metabolic comorbidities are associated with poorer outcomes. The aim of the study is to determine prevalence of liver steatosis and fibrosis in patients with COVID-19 and their association with clinical outcomes. MATERIAL AND METHODS: Retrospective study in hospitalized COVID-19 patients. Risk for liver steatosis was estimated by HSI > 36, and risk for advanced liver fibrosis with APRI > 1.0, NAFLD FS > 0.675 and/or FIB-4 > 3.25. Clinical outcomes were admission to Intensive Care Unit (ICU) and mortality. RESULTS: Of 155 patients, 71.6% were male (n = 111), and 28.4% (n = 44) were obese. Abnormal LFT were present in 96.8% (n = 150), prevalence of steatosis was 42.6% (n = 66) and of significative liver fibrosis was 44.5% (n = 69). Liver fibrosis by FIB-4 was associated with risk of ICU admission (OR 1.74 [95%CI 1.74-2.68; p = 0.023]) and mortality (OR 6.45 [95%CI 2.01-20.83, p = 0.002]), no independent associations were found. CONCLUSIONS: The prevalence of steatosis and significant liver fibrosis was high in COVID-19 patients but was not associated with clinical outcomes. url: https://api.elsevier.com/content/article/pii/S1665268120301861 doi: 10.1016/j.aohep.2020.09.015 id: cord-010036-6czkzek0 author: Lorentz, I T title: Treatment of idiopathic spasmodic torticollis with botulinum‐A toxin: a pilot study of 19 patients date: 1990-05-01 words: 3198.0 sentences: 200.0 pages: flesch: 52.0 cache: ./cache/cord-010036-6czkzek0.txt txt: ./txt/cord-010036-6czkzek0.txt summary: title: Treatment of idiopathic spasmodic torticollis with botulinum‐A toxin: a pilot study of 19 patients Nineteen patients with spasmodic torticollis, unresponsive to standard therapy, were administered local injections of botulinum‐A toxin into the affected muscles. Botulinum toxin is a very effective and safe method of treatment for spasmodic torticollis, (Med J Aust 1990; 152: 528-530) T he term "dystonia" was coined by Oppenheim in 1911 1 in describing six patients with alterations in muscle tone, sustained posturing and involuntary movements. A 48-year-old male mechanic suffering from haemochromatosis, which was treated with weekly venesections, developed spasmodic torticollis 18 months before he was referred for botulinum toxin treatment. In up to 15% of patients with ST the symptoms may remit in the first five years of the illness, so some cases of improvement may be examples of a natural remission hastened by botulinum toxin injections. Controlled trial of botulinum toxin injections in the treatment of spasmodic torticollis abstract: Nineteen patients with spasmodic torticollis, unresponsive to standard therapy, were administered local injections of botulinum‐A toxin into the affected muscles. During an average follow‐up period of 11.5 months, a more than 25% improvement was noted in 14 of 19 patients. All those with purely focal dystonia and 9 of 10 patients with a disease history of less than three years benefited from treatment. Side effects were insignificant and transient. Botulinum toxin is a very effective and safe method of treatment for spasmodic torticollis. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168378/ doi: 10.5694/j.1326-5377.1990.tb125354.x id: cord-260980-tyf3fuz9 author: Lorenzo Villalba, Noel title: Anosmia and Dysgeusia in the Absence of Other Respiratory Diseases: Should COVID-19 Infection Be Considered? date: 2020-04-03 words: 1211.0 sentences: 79.0 pages: flesch: 52.0 cache: ./cache/cord-260980-tyf3fuz9.txt txt: ./txt/cord-260980-tyf3fuz9.txt summary: title: Anosmia and Dysgeusia in the Absence of Other Respiratory Diseases: Should COVID-19 Infection Be Considered? We describe two elderly patients evaluated at emergency departments for anosmia/dysgeusia in the absence of any other respiratory symptoms prior to or upon admission. Upon admission, the patient was afebrile, his blood pressure was 110/80 mmHg, heart rate was 82 bmp and oxygen saturation was 94% on room air. Anosmia, hyposmia and dysgeusia in the absence of other respiratory diseases such as allergic rhinitis, acute rhinosinusitis or chronic rhinosinusitis, should alert physicians to the possibility of COVID-19 infection and prompt serious consideration of self-isolation and testing of these individuals. Anosmia and dysgeusia should prompt COVID-19 infection screening even in the absence of classic respiratory symptoms in the present epidemiological context. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms abstract: We describe two elderly patients evaluated at emergency departments for anosmia/dysgeusia in the absence of any other respiratory symptoms prior to or upon admission. In the current epidemiological context, clinical and biological work-up led to a diagnosis of COVID-19 infection. Unfortunately, one of the patients died during hospitalization, but the other recovered and was discharged. LEARNING POINTS: In the current epidemiological situation, anosmia and dysgeusia in the absence of other respiratory conditions should be carefully evaluated. Special attention should be given to patients with non-classic COVID-19 symptoms in order to reduce transmission and protect health providers. url: https://www.ncbi.nlm.nih.gov/pubmed/32309267/ doi: 10.12890/2020_001641 id: cord-256556-1zea3wa1 author: Lou, Yan title: Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial date: 2020-10-25 words: 4228.0 sentences: 225.0 pages: flesch: 50.0 cache: ./cache/cord-256556-1zea3wa1.txt txt: ./txt/cord-256556-1zea3wa1.txt summary: The percentage of patients who turned viral negative after 14-day treatment was 70%, 77%, and 100% in the baloxavir marboxil, favipiravir, and control group respectively, with the medians of time from randomization to clinical improvement was 14, 14 and 15 days, respectively. Then, an exploratory single center, open-label, randomized, controlled trial was conducted to evaluate the efficacy and safety of adding baloxavir marboxil or favipiravir to the current standard antiviral treatment in patients confirmed as COVID-19 who are still positive for the SARS-CoV-2 (ChiCTR2000029544). This trial was an exploratory single center, open-label, randomized, controlled trial to evaluate the efficacy and safety of adding baloxavir marboxil or favipiravir to the current standard antiviral treatment in patients confirmed as COVID-19 who are still positive for the SARS-CoV-2 (ChiCTR2000029544). The activity against SARS-CoV-2 was tested in vitro for the antiviral drugs used in this trial, including arbidol, ritonavir, lopinavir, darunavir, baloxavir acid, and favipiravir. abstract: Background: Effective antiviral drugs for COVID-19 are still lacking. This study aims to evaluate the clinical outcomes and plasma concentrations of baloxavir acid and favipiravir in COVID-19 patients. Methods: Favipiravir and baloxavir acid were evaluated for their antiviral activity against SARS-CoV-2 in vitro before the trial initiation. We conducted an exploratory trial with 3 arms involving hospitalized adult patients with COVID-19. Patients were randomized assigned in a 1:1:1 ratio into baloxavir marboxil group, favipiravir group, and control group. The primary outcome was the percentage of subjects with viral negative by Day 14 and the time from randomization to clinical improvement. Virus load reduction, blood drug concentration and clinical presentation were also observed. The trial was registered with Chinese Clinical Trial Registry (ChiCTR 2000029544). Results: Baloxavir acid showed antiviral activity in vitro with the half-maximal effective concentration (EC(50)) of 5.48 μM comparable to arbidol and lopinavir, but favipiravir didn't demonstrate significant antiviral activity up to 100 μM. Thirty patients were enrolled. The percentage of patients who turned viral negative after 14-day treatment was 70%, 77%, and 100% in the baloxavir marboxil, favipiravir, and control group respectively, with the medians of time from randomization to clinical improvement was 14, 14 and 15 days, respectively. One reason for the lack of virological effect and clinical benefits may be due to insufficient concentrations of these drugs relative to their antiviral activities. One of the limitations of this study is the time from symptom onset to randomization, especially in the baloxavir marboxil and control groups, which is higher than the favipiravir group. Conclusions: Our findings could not prove a benefit of addition of either baloxavir marboxil or favipiravir under the trial dosages to the existing standard treatment. url: https://www.sciencedirect.com/science/article/pii/S092809872030419X?v=s5 doi: 10.1016/j.ejps.2020.105631 id: cord-324148-bllyruh8 author: Loubet, Paul title: Characteristics of human metapneumovirus infection in adults hospitalized for community-acquired influenza-like illness in France, 2012-2018: a retrospective observational study date: 2020-04-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To describe the prevalence, clinical features and complications of human metapneumovirus (hMPV) infections in a population of adults hospitalized with influenza-like illness (ILI). METHODS: This was a retrospective, observational, multicenter cohort study using prospectively collected data from adult patients hospitalized during influenza virus circulation, for at least 24h, for community-acquired ILI (with symptom onset <7 days). Data were collected from five French teaching hospitals over six consecutive winters (2012-2018). Respiratory viruses were identified by multiplex RT-PCR on nasopharyngeal specimens. hMPV+ patients were compared to hMPV– patients, influenza+ and respiratory syncytial virus (RSV)+ patients using multivariate logistic regressions. Primary outcome was the prevalence of hMPV in patients hospitalized for ILI. RESULTS: Among the 3148 patients included (1449 (46%) women, 1988 (63%) aged 65 and over; 2508 (80%) with chronic disease), at least one respiratory virus was detected in 1604 (51%, 95%CI [49-53]), including 100 cases of hMPV (100/3148, 3% 95%CI [3, 4]), of which 10 (10%) were viral co-infection. In the hMPV+ patients, mean length of stay was 7 days, 62% (56/90) developed a complication, 21% (14/68) were admitted to intensive care unit and 4% (4/90) died during hospitalization. In comparison with influenza+ patients, hMPV+ patients were more frequently > 65 years old (aOR=3.3, 95%CI[1.9-6.3]) and presented more acute heart failure during hospitalization (aOR=1.8, 95%CI[1.0-2.9]). Compared to RSV+ patients, hMPV+ patients had less cancer (aOR=0.4, 95%CI[0.2-0.9]) and were less likely to smoke (aOR=0.5, 95%CI[0.2-0.9]) but had similar outcomes especially high rate of respiratory and cardiovascular complications. CONCLUSIONS: Adult hMPV infections mainly affect the elderly and patients with chronic conditions and are responsible for frequent cardiac and pulmonary complications similar to those of RSV infections. At-risk populations would benefit from the development of antivirals and vaccines targeting hMPV. url: https://www.sciencedirect.com/science/article/pii/S1198743X20301907?v=s5 doi: 10.1016/j.cmi.2020.04.005 id: cord-317468-pnxni1x5 author: Louie, Philip K. title: Early Peri-operative Outcomes Were Unchanged in Patients Undergoing Spine Surgery During the COVID-19 Pandemic in New York City date: 2020-09-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Healthcare resources have been greatly limited by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic halting non-essential surgical cases without clear service expansion protocols. QUESTIONS/PURPOSES: We sought to compare the peri-operative outcomes of patients undergoing spine surgery during the SARS-CoV-2 pandemic to a matched cohort prior to the pandemic. METHODS: We identified a consecutive sample of 127 adult patients undergoing spine surgery between March 9, 2020, and April 10, 2020, corresponding with the state of emergency declared in New York and the latest possible time for 1-month surgical follow-up. The study group was matched one-to-one based on age, gender, and body mass index with eligible control patients who underwent similar spine procedures prior to the SARS-CoV-2 outbreak. Surgeries performed for infectious or oncologic indications were excluded. Intra- and post-operative complication rates, re-operations, hospital length of stay, re-admissions, post-operative visit format, development of post-operative fever and/or respiratory symptoms, and SAR-CoV2 testing. RESULTS: A total of 254 patients (127 SARS-CoV-2 pandemic, 127 matched controls) were included. One hundred fifty-eight were male (62%), and 96 were female (38%). The mean age in the pandemic group was 59.8 ± 13.4 years; that of the matched controls was 60.3 ± 12.3. All patients underwent general anesthesia and did not require re-intubation. There were no significant differences in 1-month post-operative complication rates (16.5% pandemic vs. 12.6% control). There was one death in the pandemic group. No patients tested positive for the virus. CONCLUSION: This study represents the first report of post-operative outcomes in a large group of spine surgical patients in an area heavily affected by the SARS-CoV-2 pandemic. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11420-020-09797-x) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s11420-020-09797-x doi: 10.1007/s11420-020-09797-x id: cord-285818-eh12luma author: Louis, Shreya title: Continuous Electroencephalography Characteristics and Acute Symptomatic Seizures in COVID-19 Patients date: 2020-08-26 words: 3429.0 sentences: 217.0 pages: flesch: 53.0 cache: ./cache/cord-285818-eh12luma.txt txt: ./txt/cord-285818-eh12luma.txt summary: Objective As concerns regarding neurological manifestations in COVID-19 (coronavirus disease 2019) patients increase, limited data exists on continuous electroencephalography (cEEG) findings in these patients. This high percentage of epileptiform abnormalities (EAs) in a specific brain region in COVID-19 patients behooves the question if this is a potential epileptic effect from the SARS-CoV-2 infection or if this is a limitation with the EEG requisition method itself; since patients did not receive the minimum required 21-electrode clinical EEG recommended by American Clinical Neurophysiological Society ACNS) (Sinha et al. Whilte the main goal of this study was to report cEEG findings in a cohort of critically ill COVID-19 patients, the putative associations between survival, clinical outcomes (discharge disposition), cohort characteristics (e.g. comorbidities, age, gender) and EEG findings were also explored. As such, the two COVID-19 patients with clinical acute symptomatic seizures captured on EEG from our cohort are rare findings. abstract: Objective As concerns regarding neurological manifestations in COVID-19 (coronavirus disease 2019) patients increase, limited data exists on continuous electroencephalography (cEEG) findings in these patients. We present a retrospective cohort study of cEEG monitoring in COVID-19 patients to better explore this knowledge gap. Methods Among 22 COVID-19 patients, 19 underwent cEEGs, and 3 underwent routine EEGs (<1 hour). Demographic and clinical variables, including comorbid conditions, discharge disposition, survival and cEEG findings, were collected. Results cEEG was performed for evaluation of altered mental status (n=17) or seizure-like events (n=5). Five patients, including 2 with epilepsy, had epileptiform abnormalities on cEEG. Two patients had electrographic seizures without a prior epilepsy history. There were no acute neuroimaging findings. Periodic discharges were noted in one-third of patients and encephalopathic EEG findings were not associated with IV anesthetic use. Conclusions Interictal epileptiform abnormalities in the absence of prior epilepsy history were rare. However, the discovery of asymptomatic seizures in two of twenty-two patients was higher than previously reported and is therefore of concern. Significance cEEG monitoring in COVID-19 patients may aid in better understanding an epileptogenic potential of SARS-CoV2 infection. Nevertheless, larger studies utilizing cEEG are required to better examine acute epileptic risk in COVID-19 patients. url: https://api.elsevier.com/content/article/pii/S1388245720304430 doi: 10.1016/j.clinph.2020.08.003 id: cord-334092-50r3h7jv author: Loungani, Rahul S. title: A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response date: 2020-05-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The infection caused by severe acute respiratory syndrome coronavirus-2, or COVID-19, can result in myocardial injury, heart failure, and arrhythmias. In addition to the viral infection itself, investigational therapies for the infection can interact with the cardiovascular system. As cardiologists and cardiovascular service lines will be heavily involved in the care of patients with COVID-19, our division organized an approach to manage these complications, attempting to balance resource utilization and risk to personnel with optimal cardiovascular care. The model presented can provide a framework for other institutions to organize their own approaches and can be adapted to local constraints, resource availability, and emerging knowledge. url: https://api.elsevier.com/content/article/pii/S0002870320301320 doi: 10.1016/j.ahj.2020.04.024 id: cord-348423-zq86ms8w author: Louvardi, Maya title: Mental health in chronic disease patients during the COVID-19 quarantine in Greece date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To investigate the effect of the time spent on quarantine on distress, anxiety, depression, and somatization of chronic disease patients during the COVID-19 quarantine in Greece and the differences in these parameters between healthy individuals and chronic disease patients. METHOD: The sample consisted of 943 healthy individuals and 163 patients (respiratory, autoimmune, cardiovascular, endocrine, patients with other diseases, and patients with more than one disease) completing sociodemographic assessments as well as the 4-Dimensional Symptom Questionnaire (4DSQ) during March 30, 2020 to May 3, 2020. Pearson's correlation was used to search for the association between time spent on quarantine and the 4DSQ subscales (distress, anxiety, depression, and somatization). Independent sample T-test and Glass's Δ were used for differences between healthy individuals and chronic disease patients in these subscales, an analysis also carried out between healthy individuals and all patient subgroups. RESULTS: No statistically significant correlations were noted between the 4DSQ subscales and the quarantine duration, both for the patient and the healthy individuals’ group. Chronic disease patients had significantly higher levels of distress (p = 0.001, Δ = 0.28) and somatization (p = 0.000, Δ = 0.47), but not there were no significant differences in anxiety (p = 0.098, Δ = 0.14) and depression (p = 0.052, Δ = 0.19). Concerning head-to-head comparisons between the healthy individuals’ group and each patient group, significantly higher scores in distress were found only for patients with respiratory diseases (p = 0.028, Δ = 0.42). Regarding somatization, significantly higher scores were noted for the healthy individuals’ group compared with patients with autoimmune diseases (p = 0.010, Δ = 0.62), respiratory diseases (p = 0.027, Δ = 0.42), other diseases (p = 0.003, Δ = 0.55), and more than one disease (p = 0.012, Δ = 0.60). No statistically significant differences were found in anxiety and depression. SIGNIFICANCE OF RESULTS: The results of this study indicate that interventional programs for chronic disease patients during quarantine should focus on distress and somatization, not on anxiety and depression. Respiratory patients might have more supportive care needs compared with patients with other diseases. url: https://doi.org/10.1017/s1478951520000528 doi: 10.1017/s1478951520000528 id: cord-267132-nb0j6k3h author: Loveday, H.P. title: epic3: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England date: 2013-12-10 words: 43396.0 sentences: 2281.0 pages: flesch: 43.0 cache: ./cache/cord-267132-nb0j6k3h.txt txt: ./txt/cord-267132-nb0j6k3h.txt summary: Clinical effectiveness (i.e. using prevention measures that are based on reliable evidence of efÀ cacy) is a core component of an effective strategy designed to protect patients from the risk of infection, and when combined with quality improvement methods can account for signiÀ cant reductions in HCAI such as meticillin-resistant Staphylococcus aureus (MRSA) and Clostridium difÀ cile. Full text conÀ rms that the article: relates to infections associated with hospital hygiene; is written in English; is primary research (randomised controlled trials, prospective cohort, interrupted time series, controlled before-after, quasi-experimental, experimental studies answering speciÀ c questions), a systematic review or a meta-analysis including the above designs; and informs one or more of the review questions. 334 In a prospective cohort study using data from two randomised trials and a systematic review to estimate rates of PICC-related bloodstream infection in hospitalised patients, the author concluded that PICCs used in high-risk hospitalised patients are associated with a rate of CR-BSI similar to conventional CVCs placed in the internal jugular or subclavian veins (two to À ve per 1000 catheter-days). abstract: National evidence-based guidelines for preventing healthcare-associated infections (HCAI) in National Health Service (NHS) hospitals in England were originally commissioned by the Department of Health and developed during 1998–2000 by a nurse-led multi-professional team of researchers and specialist clinicians. Following extensive consultation, they were first published in January 2001(1) and updated in 2007.(2) A cardinal feature of evidence-based guidelines is that they are subject to timely review in order that new research evidence and technological advances can be identified, appraised and, if shown to be effective for the prevention of HCAI, incorporated into amended guidelines. Periodically updating the evidence base and guideline recommendations is essential in order to maintain their validity and authority. The Department of Health commissioned a review of new evidence and we have updated the evidence base for making infection prevention and control recommendations. A critical assessment of the updated evidence indicated that the epic2 guidelines published in 2007 remain robust, relevant and appropriate, but some guideline recommendations required adjustments to enhance clarity and a number of new recommendations were required. These have been clearly identified in the text. In addition, the synopses of evidence underpinning the guideline recommendations have been updated. These guidelines (epic3) provide comprehensive recommendations for preventing HCAI in hospital and other acute care settings based on the best currently available evidence. National evidence-based guidelines are broad principles of best practice that need to be integrated into local practice guidelines and audited to reduce variation in practice and maintain patient safety. Clinically effective infection prevention and control practice is an essential feature of patient protection. By incorporating these guidelines into routine daily clinical practice, patient safety can be enhanced and the risk of patients acquiring an infection during episodes of health care in NHS hospitals in England can be minimised. url: https://doi.org/10.1016/s0195-6701(13)60012-2 doi: 10.1016/s0195-6701(13)60012-2 id: cord-006363-xov4xwpa author: Lu, Gen title: Study of Acute Exogenous Lipoid Pneumonia date: 2016-01-29 words: 3098.0 sentences: 161.0 pages: flesch: 44.0 cache: ./cache/cord-006363-xov4xwpa.txt txt: ./txt/cord-006363-xov4xwpa.txt summary: OBJECTIVE: To analyze the clinical and imagenological characteristics of acute Exogenous lipoid pneumonia (ELP), explore its risk factors, and assess the potential role of multiple bronchoalveolar lavages (BALs) and steroid therapy in the treatment of children with acute ELP. Exogenous lipoid pneumonia (ELP) is a rare condition resulting from aspiration or inhalation of oil-based substances, with both acute and chronic forms. All patients satisfied the following diagnostic criteria: clinical presentation of acute respiratory or febrile illness combined with either radiological features diagnostic of lipoid pneumonia, or confirmation of the exogenous origin of the lipid through BAL. For each patient, the authors collected demographic data, clinical presentation, imagenological characteristics, categories of oil ingested, laboratory data, treatment, therapy response, BAL findings, and outcomes. The index study demonstrates that multiple BALs combined with steroid therapy result in significant improvement of clinical, radiologic and laboratory parameters in children with acute ELP. abstract: OBJECTIVE: To analyze the clinical and imagenological characteristics of acute Exogenous lipoid pneumonia (ELP), explore its risk factors, and assess the potential role of multiple bronchoalveolar lavages (BALs) and steroid therapy in the treatment of children with acute ELP. METHODS: Between May 2011 and July 2014, 33 pediatric patients with pneumonia caused by aspiration of oil-based substances were admitted to the Guangzhou Women and Children’s Medical Center, Guangdong, China. Data on the demographics of these patients, as well as that on clinical presentations, imagenological characteristics, history of ingestion, laboratory observations, treatment protocol, response to therapy, BAL findings, and treatment outcomes were collected. RESULTS: The study group consisted of 23 boys (69.7 %) and 10 girls (30.3 %), with ages ranging from 4 mo to 4 y. They were admitted to the hospital 2 h to 13 d after ingesting the oil-based substance. By the time of admission, most patients presented with respiratory distress and other symptoms, including tachypnea (n = 21), cough (n = 25), mild fever (n = 18), progressive dyspnea (n = 12), and pneumorrhagia (n = 5); six patients received mechanical ventilation because of complicated respiratory distress syndrome. The most common laboratory observations were leukocytosis (25 of 33, 75.8 %), neutrophilia (23 of 33, 69.7 %), and anemia (8 of 33, 24.2 %). Serum biochemical examination showed elevated sedimentation rates (24 of 33, 72.7 %), lactate dehydrogenase levels (18 of 33, 54.5 %), and C-reactive protein levels (17 of 33, 51.5 %). The most common finding on computed tomography (CT) scans was areas of consolidation. Within the follow-up duration of 2 wk to 6 mo, all patients with clinical symptoms of ELP experienced remission, and none died. The CT scans of most of the cases were normal by 1 to 3 mo, except for two patients who showed complete improvement 6 mo after treatment. CONCLUSIONS: It was found that multiple BALs combined with steroid therapy result in significant improvement of clinical, radiologic, and laboratory parameters in children with acute ELP. Further, some traditional practices may predispose children to ELP, even in the absence of underlying risk factors. Finally, pneumorrhagia and acute respiratory distress syndrome may be the main complications of acute ELP in children. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101684/ doi: 10.1007/s12098-015-2028-4 id: cord-295086-tc3re52f author: Lu, Guoguang title: Dynamic changes in routine blood parameters of a severe COVID-19 case date: 2020-05-13 words: 1749.0 sentences: 82.0 pages: flesch: 49.0 cache: ./cache/cord-295086-tc3re52f.txt txt: ./txt/cord-295086-tc3re52f.txt summary: METHODS: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. RESULTS: Our study found that the patient''s condition worsened in the first week after admission; white blood cells (WBCs), neutrophils, lymphocytes, monocytes, eosinophils, erythrocytes, hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. The number of WBCs, neutrophils, monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. In addition, it should be noted that monocytes and eosinophils were extremely low within 10 days after admission, which might indicate that the patient''s condition was serious, and then gradually recovered to normal. abstract: BACKGROUND: Novel coronavirus infectious disease (COVID-19) has been spreading worldwide, and tracking laboratory indexes during the diagnosis and treatment of patients with severe COVID-19 can provide a reference for patients in other countries and regions. METHODS: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. RESULTS: Our study found that the patient’s condition worsened in the first week after admission; white blood cells (WBCs), neutrophils, lymphocytes, monocytes, eosinophils, erythrocytes, hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. On the 7th day of admission, the levels of these cells decreased to their lowest values, though the red blood cell distribution width (RDW) and C-reactive protein (CRP) level remained at high values. From 8-14 days of admission, the patient’s condition improved, hypoxemia was corrected, and mechanical ventilation was discontinued. The number of WBCs, neutrophils, monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. Although red blood cells (RBCs) and hemoglobin (Hb) levels continued to decrease, RDW gradually increased, indicating the recovery of hematopoiesis. In addition, it should be noted that monocytes and eosinophils were at extremely low levels within 10 days after admission; the recovery time of eosinophils was approximately 12 days after admission, which was earlier than other parameters, which might be of great value in judging the progress of the disease. CONCLUSIONS: Dynamic changes in routine blood parameters might be helpful for the prognosis of COVID-19 patients and evaluation of the treatment effect. url: https://api.elsevier.com/content/article/pii/S0009898120301881 doi: 10.1016/j.cca.2020.04.034 id: cord-276438-nynri6my author: Lu, Jiade J. title: Experience of a Radiation Oncology Center Operating During the COVID-19 Outbreak date: 2020-04-10 words: 1544.0 sentences: 70.0 pages: flesch: 48.0 cache: ./cache/cord-276438-nynri6my.txt txt: ./txt/cord-276438-nynri6my.txt summary: As the executive vice president of the Shanghai Proton and Heavy Ion Center (SPHIC), a tertiary cancer treatment facility on the front line against the COVID-19 epidemic responsible for patient care and infection control, our experience and opinions might be helpful for colleagues in the United States as a reference. Anyone with a body temperature over 37.3 o C and pertinent contact/travel history is transferred to a fever clinic at a designated hospital (special clinics of major general hospitals established during the 2003 SARS epidemic to triage and treat patients with fever) to rule out COVID-19 infection. From a professional point of view, I do not think it is necessary to delay chemotherapy or radiation treatment for patients with cancer because of COVID-19, unless an infection is confirmed or highly suspected or there are other medical reasons. Except for head and neck cancer treatments, all patients are required to wear a surgical mask during transportation and radiation therapy. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32363248/ doi: 10.1016/j.adro.2020.04.003 id: cord-016211-8j8n9enn author: Lu, Puxuan title: Highly Pathogenic Avian Influenza date: 2015-04-30 words: 9573.0 sentences: 570.0 pages: flesch: 50.0 cache: ./cache/cord-016211-8j8n9enn.txt txt: ./txt/cord-016211-8j8n9enn.txt summary: Statistical analysis has demonstrated that 60-70 % human infection of avian infl uenza is severe, which may clinically develop into acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Within 1 week after onset, the conditions may rapidly progress and deteriorate into acute lung injury, acute respiratory distress syndrome, pulmonary hemorrhage, pleural effusion, pancytopenia, multiple organ failure, shock, Reye syndrome, and secondary bacterial infection and septicemia. In severe cases of human infection by avian infl uenza, the patients develop pleuritis and pleural effusion at the middle or advanced stage, mostly 6-12 days after the onset. The patients experience typical symptoms of human infection with avian infl uenza, including fever with a body temperature above 38 °C, headache, general pain, fatigue, dry throat, and poor appetite. Some severe cases with human infection of avian infl uenza might develop rapid heart rate, nodal tachycardia, and acute heart failure at day 10-18 after the onset. abstract: Highly pathogenic avian influenza is an acute respiratory infectious disease caused by some viral strains of avian influenza virus A. Its severity is highly diverse ranging from common cold-like symptoms to septicemia, shock, multiple organ failure, Reye syndrome, pulmonary hemorrhage, and other complications leading to death. According to the laws, human infection of highly pathogenic avian influenza has been legally listed as class B infectious diseases in China. And it has been stipulated that it should be managed according to class A infectious diseases in China. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120431/ doi: 10.1007/978-94-017-9882-2_18 id: cord-278300-6cr9h7no author: Lu, X. title: Classification of COVID-19 in intensive care patients: towards rational and effective clinical triage date: 2020-04-11 words: 1271.0 sentences: 98.0 pages: flesch: 46.0 cache: ./cache/cord-278300-6cr9h7no.txt txt: ./txt/cord-278300-6cr9h7no.txt summary: We aimed to bridge the gap between disease classification and clinical outcome in intensive care patients, data of which are scarce and such classification could help in individual evaluation and provide effective triage for treatment and management. We constructed a fully Bayesian latent variable model for integrative clustering of six data categories, including demographic information, symptoms, original comorbidities, vital signs, blood routine tests and inflammatory marker measurements. We identified four prognostic types of COVID-19 in intensive care patients, presenting a stepwise distribution in age, respiratory condition and inflammatory markers, suggesting the prognostic efficacy of these indicators. Little attention has been paid to the clinical characteristics and outcomes of intensive care patients with COVID-19, data of which are scarce but are of paramount importance to reduce mortality. We aimed to bridge the gap between disease classification and clinical outcome in intensive care patients, which could help in individual evaluation and provide effective triage for treatment and management. abstract: The number of pertinent researches of COVID-19 has increased rapidly but they mainly focused on the description of general information of patients with confirmed infection. We aimed to bridge the gap between disease classification and clinical outcome in intensive care patients, data of which are scarce and such classification could help in individual evaluation and provide effective triage for treatment and management. Specifically, we collected and filtered out 151 intensive care patients with complete medical records from Tongji hospital in Wuhan, China. We constructed a fully Bayesian latent variable model for integrative clustering of six data categories, including demographic information, symptoms, original comorbidities, vital signs, blood routine tests and inflammatory marker measurements. We identified four prognostic types of COVID-19 in intensive care patients, presenting a stepwise distribution in age, respiratory condition and inflammatory markers, suggesting the prognostic efficacy of these indicators. This report, to our knowledge, is the first attempt of dealing with classification of COVID-19 in intensive care patients. We acknowledge the limitation of ignoring the effect of treatment, but we believe such classification is enlightening for better triage, allowing for a more rational allocation of scarce medical resources in a resource constrained environment. url: http://medrxiv.org/cgi/content/short/2020.04.09.20058909v1?rss=1 doi: 10.1101/2020.04.09.20058909 id: cord-309194-jtouafgd author: Lu, Xiao title: Lung ultrasound score in establishing the timing of intubation in COVID-19 interstitial pneumonia: A preliminary retrospective observational study date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To investigate the role of lung ultrasound score (LUS) in assessing intubation timing for patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. MATERIALS AND METHODS: Seventy-two patients with critical coronavirus disease 2019 (COVID-19) were admitted to a makeshift intensive care unit (ICU). All patients underwent bedside lung ultrasonography one to two times per day. The patients were either intubated, treated with noninvasive ventilation (NIV), or given high-flow nasal cannula (HFNC) after a discussion with the multidisciplinary group after their conditions worsened. Bedside lung ultrasound was performed daily after intubation, and patients received mechanical ventilation. Lung ultrasound was performed on days 1, 2, 3, 5, and 7 after patients were admitted to the ICU; if the patient was intubated, LUS determination was performed before intubation within 24 h (T1) and on days 1, 2, 5, and 7 after intubation (T2, T3, T4, and T5, respectively).The goal of this study was to evaluate the severity of lung aeration loss in intubated and non-intubated patients with SARS-CoV-2 pneumonia by ultrasound at different time points within one week. RESULTS: A total of 16 patients were included in this study, including nine who were intubated and mechanically ventilated and seven patients without intubation. The number of elderly individuals in the intubated group was higher than in the non-intubated group (P < 0.05). In addition, there were more male than female patients in both groups. Patient characteristics (BMI, SOFA, and PaO(2)/FiO(2) value) were similar between the two groups (P > 0.05). The 28-day mortality rate of intubated patients was higher than that of non-intubated patients; six patients in the intubated group and two patients in the non-intubated group died. Nine intubated patients showed changes in LUS within seven days (n = 9). The mean LUS within 24 h before intubation was 12.8 ± 1.3. LUS was significantly higher on T1 than on T5 (P <0.05), and did not significantly differ from T1 to T4. Comparing LUS between intubated and non-intubated patients on T1 showed that the LUS of intubated patients was significantly higher than that of non-intubated patients (P <0.05). Between the two patient groups, oxygenation index was 140.1 ± 7.7 vs. 137.8 ± 5.9 on T1, and the respiratory rate of the two groups was 26 ± 5 vs. 28 ± 4 breaths/min. Neither oxygenation index nor RR significantly differed between the two groups. CONCLUSION: LUS may be an effective tool for assessing intubation timing in critically ill patients with Covid-19 interstitial pneumonia. url: https://www.ncbi.nlm.nih.gov/pubmed/32881950/ doi: 10.1371/journal.pone.0238679 id: cord-007575-5ekgabx5 author: Luby, James P. title: Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses date: 2016-01-14 words: 11991.0 sentences: 735.0 pages: flesch: 39.0 cache: ./cache/cord-007575-5ekgabx5.txt txt: ./txt/cord-007575-5ekgabx5.txt summary: Important trends and developments in the field include (1) the emergence of a Chlamydia psittaci strain (TWAR) that is passaged from human to human, causes a mycoplasma-like illness, and that is relatively resistant to erythromycin, (2) the recognition of respiratory syncytial virus as a pathogen in nursing home outbreaks and in immunosuppressed adults, (3) the continuing high lethality of fully developed influenza pneumonia, (4) the efficacy of acyclovir and adenine arabinoside in limiting the complications of varicella-zoster virus infections, and (5) the increasing frequency of pneumonia caused by cytomegalovirus and the severity of this disorder in highly immunosuppressed patients. Important trends and developments in the field include (1) the emergence of a Chlamydia psittaci strain (TWAR) that is passaged from human to human, causes a mycoplasma-like illness, and that is relatively resistant to erythromycin, (2) the recognition of respiratory syncytial virus as a pathogen in nursing home outbreaks and in immunosuppressed adults, (3) the continuing high lethality of fully developed influenza pneumonia, (4) the efficacy of acyclovir and adenine arabinoside in limiting the complications of varicella-zoster virus infections, and (5) the increasing frequency of pneumonia caused by cytomegalovirus and the severity of this disorder in highly immunosuppressed patients. abstract: Pneumonias in adults due to mycoplasma, chlamydiae, and viruses are a common clinical problem. These microorganisms contribute to the etiologies in 6–35% of all cases of pneumonia and are the sole pathogens in 1–17% of hospitalized cases. Important trends and developments in the field include (1) the emergence of a Chlamydia psittaci strain (TWAR) that is passaged from human to human, causes a mycoplasma-like illness, and that is relatively resistant to erythromycin, (2) the recognition of respiratory syncytial virus as a pathogen in nursing home outbreaks and in immunosuppressed adults, the continuing high lethality of fully developed influenza pneumonia, (4) the efficacy of acyclovir and adenine arabinoside in limiting the complications of varicella-zoster virus infections, and (5) the increasing frequency of pneumonia caused by cytomegalovirus and the severity of this disorder in highly immunosuppressed patients. Developments in the rapid diagnosis and therapy of respiratory syncytial virus infections with an aerosolized antiviral drug in children may pave the way for comparable advances in difficult pneumonias in adult patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119385/ doi: 10.1097/00000441-198707000-00007 id: cord-006679-nhbofufv author: Lucarelli, G. title: Bone marrow transplantation for thalassemia date: 1993 words: 2004.0 sentences: 86.0 pages: flesch: 51.0 cache: ./cache/cord-006679-nhbofufv.txt txt: ./txt/cord-006679-nhbofufv.txt summary: Early trials of allogeneic bone marrow transplantation (BMT) for homozygous beta-thalassemia and the analyses of results of transplantation in patients less then 16 years old have allowed us to identify three classes of risk using the criteria of degree of hepatomegaly, the degree of portal fibrosis and the quality of the chelation treatment given before the transplant. Allogeneic bone marrow transplantation has proved to be a radical form of cure in those patients with an HLA identical donor found within the family.2-3We report here our experience on 491 patients transplanted since January 1981 on the base of their categorization into three classes of risk) MATERIAL The best results in term of engraftment, toxicity and GvHD prophylaxis were obtained with the association of BU 14 rag/ kg, CY 200 mg/kg and CSA alone from day-2 as GvHD prophylaxis. abstract: Early trials of allogeneic bone marrow transplantation (BMT) for homozygous beta-thalassemia and the analyses of results of transplantation in patients less then 16 years old have allowed us to identify three classes of risk using the criteria of degree of hepatomegaly, the degree of portal fibrosis and the quality of the chelation treatment given before the transplant. Patients for whom all three criteria were adverse constituted class 3, patients with none of the adverse criteria constituted class one and patients with one or various association of the adverse criteria formed Class 2. Most patients older than 16 years have disease characteristics that place them in class 3 with very few in class 2. For all the patients with an HLA identical donor we are actually using two Protocols for BMT to whom the patients are assigned on the base of the class they belong to at the time of BMT and independently on the age of the patient. For class 1, class 2 and for class 3 the probabilities of survival and of event-free-survival are respectively of 98% and 94%, 87% and 84%, 100% and 67%. For those patients that were older than 16 years at the time of the transplant, the probabilities of survival are 82% and the probabilities of event-free survival are 79%. Bone marrow transplantation is a new form of radical treatment of thalassemia in those patients with an HLA identical donor. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102227/ doi: 10.1007/bf02751428 id: cord-260083-c1r9zn43 author: Lucatelli, Pierleone title: Heparin-Related Major Bleeding in Covid-19-Positive Patient: Perspective from the Outbreak date: 2020-05-28 words: 524.0 sentences: 38.0 pages: flesch: 40.0 cache: ./cache/cord-260083-c1r9zn43.txt txt: ./txt/cord-260083-c1r9zn43.txt summary: • Bleeding patients usually require blood transfusion which is in short supply during the Covid pandemic due to the lockdown and fear of entering medical facilities • Biocontainment transfer of Covid-19-positive patients within the hospital is complex and not easy to achieve [5] In view of these considerations, interventional radiology plays a crucial role and a dedicated treatment pathway should be set up. In conclusion, although major bleeding seems to be rare in Covid-19 patients, its management is complex for several reasons: the need to continue anticoagulation, shortage of blood products, multiple sites of haemorrhage and logistic issues. Ethical Approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. abstract: nan url: https://doi.org/10.1007/s00270-020-02532-3 doi: 10.1007/s00270-020-02532-3 id: cord-009417-458rrhcm author: Luce, Judith A. title: Use of Blood Components in the Intensive Care Unit date: 2009-05-15 words: 17101.0 sentences: 918.0 pages: flesch: 43.0 cache: ./cache/cord-009417-458rrhcm.txt txt: ./txt/cord-009417-458rrhcm.txt summary: Benefi ts to the patient with more judicious use of platelet transfusion include decreased donor exposure, which lessens the risk of transfusion-transmitted disease; fewer febrile and allergic reactions that may complicate the hospital course; and the potential delay or prevention of alloimmunization to HLA and platelet antigens. If anti-IgA antibodies are determined to be the cause of this reaction, the patient must receive blood components donated by IgA-defi cient individuals or, if unavailable, specially prepared washed RBCs and platelet concentrates. These patients may have intensive red cell and platelet transfusion requirements and need specialized products such as CMV-negative and irradiated blood components. A blood bank problem uniquely encountered in BMT is the need to switch the patient''s ABO group because of an ABO-mismatched transplant, thus necessitating an exchange transfusion of red cells and plasma-containing products (i.e., platelet concentrates) of differing ABO type to avoid hemolysis of donor and recipient cells. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152226/ doi: 10.1016/b978-032304841-5.50082-0 id: cord-019010-9xgwjvsv author: Luna, C. M. title: Life-threatening Respiratory Failure from H1N1 Influenza: Lessons from the Southern Cone Outbreak date: 2010-06-23 words: 4578.0 sentences: 192.0 pages: flesch: 35.0 cache: ./cache/cord-019010-9xgwjvsv.txt txt: ./txt/cord-019010-9xgwjvsv.txt summary: Consistent with this particular situation, the health system in the metropolitan area of Buenos Aires began to show evidences of collapse, use of ventilators increased critically, achieving an extremely unusual level; about a quarter of the available ICU beds were occupied by young and previously healthy patients with ARDS associated with severe bilateral pneumonia due to ''swine flu'' who needed mechanical ventilation. These figures are difficult to extrapolate globally and to confirm, as epidemiological studies looking at the population at risk in different world areas are lacking, but the huge number of severely ill patients with ARDS due to primary influenza pneumonia (an extremely unusual complication) observed in the Southern Cone, suggest that these estimations could be realistic. Viral cultures of respiratory specimens, especially if A 29 year-old obese male with arterial hypertension secondary to Cushing''s disease (hypophyseal adenoma) developed bilateral pneumonia and died from respiratory failure secondary to acute respiratory distress syndrome (ARDS) after 13 days on mechanical ventilation, with multiple organ failure, including renal and hemodynamic compromise requiring high doses of vasopressors. abstract: A sharp increase in the hospitalization rate for pneumonia, particularly among adults between 20 and 40 years old, and an unusual series of deaths, coincident with an increase in laboratory-confirmed influenza cases, were reported in the spring of 2009 in Mexico. This outbreak appeared after the end of influenza season, and was associated with mortality in a younger age-group than the pattern observed in temperate areas in the northern hemisphere [1]. The concurrent finding of a novel, swine-origin influenza A virus (so called pandemic influenza [H1N1] 2009) from infected children in the United States [2] completed the picture. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124051/ doi: 10.1007/978-3-642-10286-8_20 id: cord-279158-dsnniuo6 author: Luo, Y. title: Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study date: 2020-05-22 words: 3903.0 sentences: 200.0 pages: flesch: 47.0 cache: ./cache/cord-279158-dsnniuo6.txt txt: ./txt/cord-279158-dsnniuo6.txt summary: title: Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study Through a systematic review, meta-analysis and retrospective cohort study, we found that the low blood sodium population may significantly increase the risk and severity of SARS-CoV-2 infection. In this study, we aimed to find a key risk factor for SARS-CoV-2 epidemic by investigating the relationship between the blood sodium concentration and the severity of patients with COVID-19 through a systematic reviews, meta-analysis and retrospective cohort study. For the systematic review and meta-analysis, median or mean values of serum sodium, chloride and potassium concentrations from each report were considered as an independent variable for statistical analysis, and an unpaired t-test was used to compare the differences between the groups related to the severity of disease. In this study, we found that the patients infected by SARS-CoV-2 on admission have presented the low blood sodium levels (hyponatremia) that were related to the disease severity. abstract: Background Novel coronavirus (SARS-CoV-2) infects human lung tissue cells through angiotensin-converting enzyme-2 (ACE2), and the body sodium is an important factor for regulating the expression of ACE2. Through a systematic review, meta-analysis and retrospective cohort study, we found that the low blood sodium population may significantly increase the risk and severity of SARS-CoV-2 infection. Methods We extracted the data of serum sodium concentrations of patients with COVID-19 on admission from the articles published between Jan 1 and April 28, 2020, and analyzed the relationship between the serum sodium concentrations and the illness severity of patients. Then we used a cohort of 244 patients with COVID-19 for a retrospective analysis. Results We identified 36 studies, one of which comprised 2736 patients.The mean serum sodium concentration in patients with COVID-19 was 138.6 mmol/L, which was much lower than the median level in population (142.0). The mean serum sodium concentration in severe/critical patients (137.0) was significantly lower than those in mild and moderate patients (140.8 and 138.7, respectively). Such findings were confirmed in a retrospective cohort study, of which the mean serum sodium concentration in all patients was 137.5 mmol/L, and the significant differences were found between the mild (139.2) and moderate (137.2) patients, and the mild and severe/critical (136.6) patients. Interestingly, such changes were not obvious in the serum chlorine and potassium concentrations. Conclusions The low sodium state of patients with COVID-19 may not be the consequence of virus infection, but could be a physiological state possibly caused by living habits such as low salt diet and during aging process, which may result in ACE2 overexpression, and increase the risk and severity of COVID-19. These findings may provide a new idea for the prevention and treatment of COVID-19. url: http://medrxiv.org/cgi/content/short/2020.05.18.20102509v1?rss=1 doi: 10.1101/2020.05.18.20102509 id: cord-321346-epsp3bbm author: Luppa, Peter B. title: Point-of-care testing (POCT): Current techniques and future perspectives date: 2011-03-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Point-of-care testing (POCT) is a laboratory-medicine discipline that is evolving rapidly in analytical scope and clinical application. In this review, we first describe the state of the art of medical-laboratory tests that can be performed near the patient. At present, POCT ranges from basic blood-glucose measurement to complex viscoelastic coagulation assays. POCT shortens the time to clinical decision-making about additional testing or therapy, as delays are no longer caused by transport and preparation of clinical samples, and biochemical-test results are rapidly available at the point of care. Improved medical outcome and lower costs may ensue. Recent, evolving technological advances enable the development of novel POCT instruments. We review the underlying analytical techniques. If new instruments are not yet in practical use, it is often hard to decide whether the underlying analytical principle has real advantage over former methods. However, future utilization of POCT also depends on health-care trends and new areas of application. But, even today, it can be assumed that, for certain applications, near-patient testing is a useful complement to conventional laboratory analyses. url: https://www.ncbi.nlm.nih.gov/pubmed/32287536/ doi: 10.1016/j.trac.2011.01.019 id: cord-104055-47ren7ie author: Lutkenhoff, Evan S. title: EEG power spectra and subcortical pathology in chronic disorders of consciousness date: 2020-09-01 words: 2479.0 sentences: 127.0 pages: flesch: 49.0 cache: ./cache/cord-104055-47ren7ie.txt txt: ./txt/cord-104055-47ren7ie.txt summary: Objective To determine (i) the association between long-term impairment of consciousness after severe brain injury, spontaneous brain oscillations, and underlying subcortical damage, and (ii) whether such data can be used to aid patient diagnosis, a process known to be susceptible to high error rates. Conclusions These results ground, for the first time, electroencephalographic presentation detected with routine clinical techniques in the underlying brain pathology of disorders of consciousness and demonstrate how multimodal combination of clinical, electroencephalographic, and imaging data can be employed in potentially mitigating the high rates of misdiagnosis typical of this patient cohort. Sex, 19 age, time-post-injury, etiology (i.e., TBI vs non-TBI), were included as covariates, 20 along with NBV (to ensure that observed tissue displacement reflect local subcortical 21 shape changes independent of overall brain atrophy ( In this analysis, we related the patients'' behavioral presentation, as captured by the 7 CRS-R subscales, with subcortical atrophy. abstract: Objective To determine (i) the association between long-term impairment of consciousness after severe brain injury, spontaneous brain oscillations, and underlying subcortical damage, and (ii) whether such data can be used to aid patient diagnosis, a process known to be susceptible to high error rates. Methods Cross-sectional observational sample of 116 patients with a disorder of consciousness secondary to brain injury, collected prospectively at a tertiary center between 2011 and 2013. Multimodal analyses relating clinical measures of impairment, electroencephalographic measures of spontaneous brain activity, and magnetic resonance imaging data of subcortical atrophy were conducted in 2018. Results In the final analyzed sample of 61 patients, systematic associations were found between electroencephalographic power spectra and subcortical damage. Specifically, the ratio of beta-to-delta relative power was negatively associated with greater atrophy in regions of the bilateral thalamus and globus pallidus (both left > right) previously shown to be preferentially atrophied in chronic disorders of consciousness. Power spectrum total density was also negatively associated with widespread atrophy in regions of the left globus pallidus, right caudate, and in brainstem. Furthermore, we showed that the combination of demographics, encephalographic, and imaging data in an analytic framework can be employed to aid behavioral diagnosis. Conclusions These results ground, for the first time, electroencephalographic presentation detected with routine clinical techniques in the underlying brain pathology of disorders of consciousness and demonstrate how multimodal combination of clinical, electroencephalographic, and imaging data can be employed in potentially mitigating the high rates of misdiagnosis typical of this patient cohort. Search terms disorders of consciousness, subcortical pathology, EEG, MRI. url: https://doi.org/10.1101/695288 doi: 10.1101/695288 id: cord-331500-l3hkn2li author: Luyt, Charles-Edouard title: Pulmonary infections complicating ARDS date: 2020-11-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Pulmonary infection is one of the main complications occurring in patients suffering from acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of lung immune defenses and microbiota may play an important role in ARDS patients. Prone positioning does not seem to be associated with a higher risk of pulmonary infection. Although bacteria associated with ventilator-associated pneumonia (VAP) in ARDS patients are similar to those in patients without ARDS, atypical pathogens (Aspergillus, herpes simplex virus and cytomegalovirus) may also be responsible for infection in ARDS patients. Diagnosing pulmonary infection in ARDS patients is challenging, and requires a combination of clinical, biological and microbiological criteria. The role of modern tools (e.g., molecular methods, metagenomic sequencing, etc.) remains to be evaluated in this setting. One of the challenges of antimicrobial treatment is antibiotics diffusion into the lungs. Although targeted delivery of antibiotics using nebulization may be interesting, their place in ARDS patients remains to be explored. The use of extracorporeal membrane oxygenation in the most severe patients is associated with a high rate of infection and raises several challenges, diagnostic issues and pharmacokinetics/pharmacodynamics changes being at the top. Prevention of pulmonary infection is a key issue in ARDS patients, but there is no specific measure for these high-risk patients. Reinforcing preventive measures using bundles seems to be the best option. url: https://doi.org/10.1007/s00134-020-06292-z doi: 10.1007/s00134-020-06292-z id: cord-327632-2hz94uuw author: Lv, Na title: Management of oral medicine emergencies during COVID-19: A study to develop practice guidelines date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease (COVID-19) pandemic has become a significant global public health concern. Since the announcement of the Public Health Emergency of International Concern, many countries have implemented lockdown and restrictive quarantines; therefore, routine dentistry, as well as oral medicine practice, have been suspended in several countries. However, urgent oral cares and emergencies are still operated and delivered by on-call dental practitioners. The objective of this study was to investigate the management of oral medicine emergency during a viral pandemic such as COVID-19. During the lockdown period, digital technologies, such as video conferencing with Zoom, Google Meeting or WhatsApp, are useful and efficient tools that oral medicine practitioners could consider to use for patient triage, managing emergencies, reassure, and follow patients remotely. Oral medicine emergencies can be carefully evaluated and triaged via video conferencing and sometimes phone contact, to avoid life-threatening risks while realising the limitations by both patient and clinician. url: https://www.sciencedirect.com/science/article/pii/S1991790220301744?v=s5 doi: 10.1016/j.jds.2020.07.016 id: cord-331268-kzy33hdb author: Lynch, Sharon G. title: Multiple sclerosis date: 1996-01-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Multiple sclerosis is a chronic disease that begins in late adolescence or adulthood. It is highly variable in its expression and severity. It is believed to be autoimmune in nature. The cause is unknown; both genetic and environmental factors have been implicated in the pathogenesis. MS generally presents with the acute or subacute onset of neurologic abnormalities that may wax and wane over many years. Diagnosis is generally made by means of observation of the clinical course in conjunction with a neurologic examination and laboratory tests. These tests may include magnetic resonance imaging of the head and spine, lumbar puncture, and evoked potentials. Treatment is based on general supportive care, the use of corticosteroids for relapses, and symptomatic management of ongoing problems. The frequency of relapses can be reduced with interferon-β (Betaseron). Copolymer 1 and interferon-β la are being evaluated by the U.S. Food and Drug Administration for approval for use for reduction in the frequency of relapses in relapsing-remitting MS. Treatment of chronic progression is often attempted with immunosuppressive agents such as corticosteroids, azathioprine, and cyclophosphamide. Use of other agents is being investigated. url: https://www.sciencedirect.com/science/article/pii/S0011502996900127 doi: 10.1016/s0011-5029(96)90012-7 id: cord-312033-iarl77n0 author: López Barreda, Rodrigo title: Poverty, quality of life and psychological wellbeing in adults with congenital heart disease in Chile date: 2020-10-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The objective of this study was to assess the quality of life and psychological wellbeing of adults with congenital heart disease (CHD) in Chile, and to identify other associated factors. The study enrolled 68 patients aged between 18 and 72 (median 29), 35 being females. They completed a questionnaire, which included a quality of life assessment tool (the Medical Outcome Study 36-Item Short Form Health Survey), a number of psychological scales (the General Health Questionnaire, the Basic Psychological Needs Scales and the Beck Hopelessness Scale), a socioeconomic survey, and some clinical data. CHD patients reported worse scores in those scales assessing physical dimensions of quality of life (physical function (70.5), physical role functioning (64), vitality (65.3)), and general quality of life (58.6), than in emotional or social dimensions. Female gender was associated with lower scores in physical function (59.12 versus 82.66; p<0.01) and physical role functioning (53.68 versus 75; p<0.05); poverty was associated with worse results in physical function (61.92 versus 82.96; p<0.01), role physical (53.21 versus 79.63; p<0.01), vitality (60.89 versus 71.67; p<0.05), social role functioning (70.19 versus 82.87; p<0.05) and bodily pain (65.77 versus 81.2; p<0.05). Furthermore, we found that psychological scales had an association with quality of life, but clinical variables did not show significant correlations to any dimension. Poverty has an impact on the quality of life of CHD patients. This population only has a decrease in the quality of life physical dimensions, suggesting that quality of life depends on many different factors. url: https://doi.org/10.1371/journal.pone.0240383 doi: 10.1371/journal.pone.0240383 id: cord-330369-75cotmn2 author: López, Verónica title: Recommendations on management of the SARS-CoV-2 coronavirus pandemic (Covid-19) in kidney transplant patients date: 2020-04-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The SARS-CoV-2 (Covid-19) coronavirus pandemic is evolving very quickly and means a special risk for both immunosuppressed and comorbid patients. Knowledge about this growing infection is also increasing although many uncertainties remain, especially in the kidney transplant population. This manuscript presents a proposal for action with general and specific recommendations to protect and prevent infection in this vulnerable population such as kidney transplant recipients. url: https://api.elsevier.com/content/article/pii/S2013251420300481 doi: 10.1016/j.nefroe.2020.03.017 id: cord-340051-r9kn34wd author: MEI, Xue title: Observations about Symptomatic and Asymptomatic infections of 494 patients with COVID-19 in Shanghai,China date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Humans are generally susceptible to SARS-CoV-2, which has caused a global pandemic of COVID-19. The screening of infected people in the population still mainly depends on clinical symptoms. However, there is limited research on the characteristics of clinical symptoms in different populations, especially in imported cases. METHODS: To retrospectively analyze the clinical data of 494 confirmed COVID-19 patients admitted to a designated hospital in Shanghai from January 20, 2020, to March 31, 2020, we compared the clinical manifestations in different populations and their influencing factors in COVID-19 patients. RESULTS: (1) Of the 494 patients, 453 (91.7%) had different symptoms at admission, and 39 (7.89%) patients were asymptomatic. (2) We compared the symptoms of patients according to different stratifications and found the following results: a. The proportion of dyspnea was significantly higher in male patients than in female patients (P < 0.05). b. The proportions of a stuffy nose, sore throat, and olfactory and gustatory dysfunction were significantly higher in children than in adult patients (P < 0.05). c. The proportions of fever, chest tightness, shortness of breath, and fatigue were significantly higher in local cases than in imported cases. In comparison, the proportions of nasal congestion, stuffy nose, sore throat, headache, and olfactory and gustatory dysfunction were significantly lower in imported cases than in imported cases (P < 0.05). d. The proportions of chest tightness, shortness of breath, and dyspnea were significantly higher in severely ill patients than in those with mild symptoms (P < 0.05). (3) Thirty-one asymptomatic patients were significantly younger than symptomatic patients, and they had a higher proportion of imported cases, white blood cell (WBC) and lymphocyte (LYM) count levels, and fewer abnormal CT cases than the group of symptomatic patients (P < 0.05). (4) The number of days since the onset of the disease needed for the symptoms to disappear was associated with the epidemiological history (imported cases), the number of days until the pharyngeal swab nucleic acid test turned negative, the days of hospitalization, the days of onset, and the WBC and LYM count levels (P < 0.05). CONCLUSION: The majority of COVID-19 patients (91.7%) had early symptoms. whereas 7.89% of COVID-19 patients were asymptomatic. Younger patients had fewer symptoms, mainly the upper respiratory symptoms, and the illness condition was milder, which was more common in imported cases. Elderly male patients had severe symptoms when admitted. The number of days needed for the patient's symptoms to disappear was closely related to the number of days necessary for the pharyngeal swab nucleic acid test to turn negative. url: https://api.elsevier.com/content/article/pii/S0196655320306465 doi: 10.1016/j.ajic.2020.06.221 id: cord-281283-h6yai7sx author: Ma, Jun title: Emergency response strategy for containing COVID-19 within a psychiatric specialty hospital in the epicenter of the COVID-19 epidemic in China date: 2020-08-04 words: 2194.0 sentences: 108.0 pages: flesch: 40.0 cache: ./cache/cord-281283-h6yai7sx.txt txt: ./txt/cord-281283-h6yai7sx.txt summary: Because SARS-CoV-2 is highly infectious, and the general population is susceptible, it is difficult to effectively prevent the spread of COVID-19 based on the current instruments, medical staff, and management modes of mental health institutions. On February 13, the Wuhan epidemic prevention and control command instructed that an isolation ward should be established to treat patients with mental illnesses with confirmed or suspected of COVID-19 infection. During the outbreak, all impairmentspecific settings were replanned to allow for the most effective prevention and control of COVID-19, and the functions of the psychiatric wards were reallocated according to the following plan 9 : (1) a ward for confirmed COVID-19 patients: this ward is used for the treatment of COVID-19 patients, and the patients are classified and managed according to disease severity; secondary protections should be implemented. abstract: Coronavirus disease 2019 (COVID-19) has been recognized as a global pandemic, and psychiatric institutions located in the epicenter of the epidemic in China are facing severe challenges in fighting the epidemic. This article presents the accumulated experience of the authors during the process of combating COVID-19 in a psychiatric hospital. The aim of this article is to provide a reference for psychiatric specialty hospitals and institutions that treat large populations of chronically ill patients in other parts of the world. url: https://doi.org/10.1038/s41398-020-00959-3 doi: 10.1038/s41398-020-00959-3 id: cord-322009-0cwljo0c author: Ma, Ling title: Coinfection of SARS-CoV-2 and Other Respiratory Pathogens date: 2020-08-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To differentiate between respiratory infections caused by SARS-CoV-2 and other respiratory pathogens during the COVID-19 outbreak in Wuhan, we simultaneously tested for SARS-CoV-2 and pathogens associated with CAP to determine the incidence and impact of respiratory coinfections in COVID-19 patients. PATIENTS AND METHODS: We included 250 patients who were diagnosed with COVID-19. RT-PCR was used to detect influenza A, influenza B and respiratory syncytial viruses. Chemiluminescence immunoassays were used to detect IgM antibodies for adenovirus, Chlamydia pneumoniae and Mycoplasma pneumoniae in the serum of patients. Based on these results, we divided the patients into two groups, the simple SARS-CoV-2-infected group and the coinfected SARS-COV-2 group. Coinfected patients were then further categorized as having a coinfection of viral pathogen (CoIV) or coinfection of atypical bacterial pathogen (CoIaB). RESULTS: No statistically significant differences were found in age, gender, the time taken to return negative SARS-CoV-2 nucleic acid test results, length of hospital stays, and mortality between the simple SARS-CoV-2 infection group and the coinfection group. Of the 250 hospitalized COVID-19 patients, 39 (15.6%) tested positive for at least one respiratory pathogen in addition to SARS-CoV-2. A third of these pathogens were detected as early as the 1st week after symptom onset and another third were identified after more than three weeks. The most detected CAP pathogen was C. pneumoniae (5.2%), followed by the respiratory syncytial virus (4.8%), M. pneumoniae (4.4%) and adenovirus (2.8%). Patients coinfected with viral pathogens (CoIV) (n=18) had longer hospital stays when compared to patients coinfected with atypical bacterial pathogens (CoIaB) (n=21). Except for one fatality, the remaining 38 coinfected patients all recovered with favourable outcomes. CONCLUSION: Coinfections in COVID-19 patients are common. The coinfecting pathogens can be detected at variable intervals during COVID-19 disease course and remain an important consideration in targeted treatment strategies for COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32922049/ doi: 10.2147/idr.s267238 id: cord-339913-ps4nvvaz author: Ma, Min title: How cardiologists respond to COVID-19: the experience of West China Hospital, China date: 2020-07-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s11739-020-02413-0 doi: 10.1007/s11739-020-02413-0 id: cord-269289-6uog10j4 author: Mabillard, Holly title: Electrolyte Disturbances in SARS-CoV-2 Infection date: 2020-07-22 words: 5684.0 sentences: 289.0 pages: flesch: 44.0 cache: ./cache/cord-269289-6uog10j4.txt txt: ./txt/cord-269289-6uog10j4.txt summary: These include additional respiratory complications (pulmonary fibrosis -reported in 21% of those hospitalised with SARS-CoV-2 9 months post-discharge in one study 3 ) 7 , cardiovascular complications (acute cardiac injury (7% 8 ), cardiomyopathy (1/3 patients 9 ), cardiac tamponade, heart failure, dysrhythmias (17% 8 ) and venous thromboembolic events (20% 10 )) 11 , neurological complications (myopathy, acute stroke (5.7% of those with severe infection 12 ), Guillain-Barre syndrome (0.4% hospitalised patients 11 ) and encephalopathy) 13 , acute liver and/or pancreatic injury (29% and 17% respectively in one cohort) 14 , cytokine storm syndrome, septic shock, DIC, diarrhoea, Kawasaki-like disease 14 and renal complications (acute tubular injury, rhabdomyolysis, proteinuria, secondary focal segmental glomerulosclerosis and possible renin-angiotensinaldosterone system activation) 15 . The study reported that the degree of hypokalaemia correlated with severity of SARS-CoV-2 symptoms and they suggested that hypokalaemia can be difficult to correct as seen in two patients because the renal potassium wasting persists until clinical recovery from the virus. abstract: The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to unprecedented global morbidity and mortality. With a bewildering array of complications, renal involvement in various forms is common, including serum electrolyte derangements. Hypokalaemia secondary to SARS-CoV-2 was common in a reported Chinese cohort. Here we review the emerging evidence on hypokalaemia and SARS-CoV-2 infection, the potential pathophysiological mechanisms based on early clinical and histopathological data and important clinical implications. Mechanisms of hypokalaemia are multifactorial and so the electrolyte disturbance can be difficult to avoid. We provide further support to the theory of renin-angiotensin-aldosterone (RAS) activation, discuss the strengths and weaknesses of implicating RAS involvement and highlight the importance of calculating the transtubular potassium gradient to identify those at risk of hypokalaemia and its complications. url: https://www.ncbi.nlm.nih.gov/pubmed/33093945/ doi: 10.12688/f1000research.24441.2 id: cord-338900-8ojah695 author: MacDonald, David S. MacDonald title: Guidelines for Oral and Maxillofacial Imaging: COVID-19 Considerations date: 2020-10-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SARS-CoV-2, the virus causing the current COVID-19 pandemic, is not only highly infectious but can induce serious outcomes in vulnerable individuals including dental patients and dental health care providers (DHCP). Responses to COVID-19 have been published by the Centers for Disease Control and Prevention and the American Dental Association but a more specific response is required for the safe practice of oral and maxillofacial radiology. We aim to review the current knowledge of how the disease threatens patients and DHCPs and how to determine which patients are likely to be SARS-Cov-2 infected; consider how the use of personal protective equipment and infection control measures based on current best practices and science can reduce the risk of disease transmission during radiologic procedures; and examine how intraoral radiography, with its potentially greater risk of spreading the disease, might be replaced by extraoral radiographic techniques for certain diagnostic tasks. This is complemented by a flowchart that can be displayed in all dental offices. url: https://www.sciencedirect.com/science/article/pii/S2212440320312840?v=s5 doi: 10.1016/j.oooo.2020.10.017 id: cord-309706-kikx05dj author: MacDonald, Scott title: Implementing a 2019 coronavirus disease airway management strategy for a provincial critical care and ground transport program date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1017/cem.2020.413 doi: 10.1017/cem.2020.413 id: cord-322893-av8hj005 author: MacKoul, Paul title: Laparoscopic-assisted myomectomy with uterine artery occlusion at a freestanding ambulatory surgery center: a case series date: 2020-06-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Non-hysteroscopic myomectomy is infrequently performed in a freestanding ambulatory setting, in part due to risks of intraoperative hemorrhage. There are also concerns about increased surgical risks for morbidly obese patients in this setting. The purpose of this study is to report the surgical outcomes of a series of laparoscopic-assisted myomectomy (LAM) cases at a freestanding ambulatory surgery center (ASC), including a comparative analysis of outcomes in morbidly obese patients (BMI > 40 kg/m(2)). METHODS: A retrospective comparative analysis was performed of 969 women, age 18 years or older, non-pregnant, who underwent LAM by one of two high volume, laparoscopic gynecologic surgical specialists at a freestanding ambulatory surgery center serving the Washington, DC area, between October 2013 and February 2019. Reversible occlusion was performed laparoscopically by placing a latex-based rubber catheter as a tourniquet around the isthmus of the uterus, causing a temporary occlusion of the bilateral uterine arteries. Permanent occlusion was performed laparoscopically via retroperitoneal dissection and uterine artery ligation at the origin of the anterior branch of the internal iliac artery. Minilaparotomy was performed for specimen removal in all cases. No power morcellation was used. Postoperative complications were graded using the Clavien-Dindo Classification system. Outcomes were compared across BMI categories using Pearson Chi-Square. RESULTS: Average myoma weight and size were 422.7 g and 8.3 cm, respectively. Average estimated blood loss (EBL) was 192.1 mL; intraoperative and grade 3 postoperative complication rates were 1.4% and 1.6%, respectively. While EBL was significantly higher in obese and morbidly obese patients, this difference was not clinically meaningful, with no significant difference in blood transfusion rates. There were no statistically significant intraoperative or postoperative complication rates across BMI categories. There was a low rate of hospital transfers (0.7%) for all patients. CONCLUSION: Laparoscopic-assisted myomectomy can be performed safely in a freestanding ambulatory surgery setting, including morbidly obese patients. This is especially important in the age of COVID-19, as elective surgeries have been postponed due to the 2020 pandemic, which may lead to a dramatic and permanent shift of outpatient surgery from the hospital to the ASC setting. url: https://www.ncbi.nlm.nih.gov/pubmed/32565764/ doi: 10.1186/s10397-020-01075-2 id: cord-305134-s7h6bpof author: Mackman, Nigel title: Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses date: 2020-07-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The world is amid a pandemic caused by severe acute respiratory syndrome-coronavirus 2. Severe acute respiratory syndrome-coronavirus causes serious respiratory tract infections that can lead to viral pneumonia, acute respiratory distress syndrome, and death. Some patients with coronavirus disease 2019 (COVID-19) have an activated coagulation system characterized by elevated plasma levels of d-dimer—a biomarker of fibrin degradation. Importantly, high levels of D-dimer on hospital admission are associated with increased risk of mortality. Venous thromboembolism is more common than arterial thromboembolism in hospitalized COVID-19 patients. Pulmonary thrombosis and microvascular thrombosis are observed in autopsy studies, and this may contribute to the severe hypoxia observed in COVID-19 patients. It is likely that multiple systems contribute to thrombosis in COVID-19 patients, such as activation of coagulation, platelet activation, hypofibrinolysis, endothelial cell dysfunction, inflammation, neutrophil extracellular traps, and complement. Targeting these different pathways may reduce thrombosis and improve lung function in COVID-19 patients. url: https://doi.org/10.1161/atvbaha.120.314514 doi: 10.1161/atvbaha.120.314514 id: cord-294184-jte9xx5e author: Macleod, Jack title: Surgery during COVID-19 crisis conditions: can we protect our ethical integrity against the odds? date: 2020-06-12 words: 2742.0 sentences: 175.0 pages: flesch: 48.0 cache: ./cache/cord-294184-jte9xx5e.txt txt: ./txt/cord-294184-jte9xx5e.txt summary: Careful consideration of ethical principles must guide production of local guidance ensuring consistent patient selection thus preserving equality as well as quality of clinical services. As a surgical department operating under COVID-19 (severe acute respiratory syndrome coronavirus 2) crisis conditions, a multitude of ethical, practical and medical dilemmas are encountered. Coupling the unclear risk profile of COVID-19 with a lack of alternatives to provide the gold standard surgery, what is the ethical justification for performing a substitute procedure on this cohort of patients? hoW CAn We eThICAlly proVIde The TrAdITIonAl gold sTAndArd, or AlTernATIVe, operATIon To pATIenTs durIng The CoVId-19 CrIsIs? One such framework has formed the basis of healthcare ethics: initially proposed by Beauchamp and Childress in 1979, the four principles of patient care are beneficence, non-maleficence, respect for autonomy and justice. For those patients requiring acute treatment, an alternative to the conventional gold standard can be performed if its known inferiority is outweighed by the reduced risk of COVID-19-related complications. abstract: COVID-19 is reducing the ability to perform surgical procedures worldwide, giving rise to a multitude of ethical, practical and medical dilemmas. Adapting to crisis conditions requires a rethink of traditional best practices in surgical management, delving into an area of unknown risk profiles. Key challenging areas include cancelling elective operations, modifying procedures to adapt local services and updating the consenting process. We aim to provide an ethical rationale to support change in practice and guide future decision-making. Using the four principles approach as a structure, Medline was searched for existing ethical frameworks aimed at resolving conflicting moral duties. Where insufficient data were available, best guidance was sought from educational institutions: National Health Service England and The Royal College of Surgeons. Multiple papers presenting high-quality, reasoned, ethical theory and practice guidance were collected. Using this as a basis to assess current practice, multiple requirements were generated to ensure preservation of ethical integrity when making management decisions. Careful consideration of ethical principles must guide production of local guidance ensuring consistent patient selection thus preserving equality as well as quality of clinical services. A critical issue is balancing the benefit of surgery against the unknown risk of developing COVID-19 and its associated complications. As such, the need for surgery must be sufficiently pressing to proceed with conventional or non-conventional operative management; otherwise, delaying intervention is justified. For delayed operations, it is our duty to quantify the long-term impact on patients’ outcome within the constraints of pandemic management and its long-term outlook. url: https://doi.org/10.1136/medethics-2020-106446 doi: 10.1136/medethics-2020-106446 id: cord-278549-br9rr713 author: Madanelo, M. title: The impact of the COVID‐19 pandemic on the utilization of emergency urological services date: 2020-05-14 words: 1717.0 sentences: 106.0 pages: flesch: 54.0 cache: ./cache/cord-278549-br9rr713.txt txt: ./txt/cord-278549-br9rr713.txt summary: OBJECTIVES: To compare the number of patients attending the Urology ED of Centro Hospitalar Universitário do Porto (CHUP), as well as their demographic characteristics, the reasons for admission, the clinical severity under the Manchester triage system (MTS), and the need for emergency surgery or hospitalization, during the pandemic and the equivalent period in 2019. The aim of this study was to compare the number of patients who attended the Urology emergency ward of a Portuguese Tertiary Hospital -Centro Hospitalar Universitário do Porto (CHUP), as well as their demographic characteristics and the main causes of presentation to the ED, during the COVID-19 pandemic and the equivalent period at the previous year. During the COVID-19 pandemic, on the aforementioned dates, 46.4% fewer patients visited our urological emergency service compared with the homologous period of time one year ago (122 vs. However, significantly fewer female patients sought emergency urological services during the COVID-19 pandemic period (32.7% vs. abstract: OBJECTIVES: To compare the number of patients attending the Urology ED of Centro Hospitalar Universitário do Porto (CHUP), as well as their demographic characteristics, the reasons for admission, the clinical severity under the Manchester triage system (MTS), and the need for emergency surgery or hospitalization, during the pandemic and the equivalent period in 2019. Patients and Methods: Data were collected from patients attending the Urology emergency ward of CHUP during three weeks ‐ from March 11th 2020 to April 1st 2020 ‐ and from the same period the previous year (from March 11th to April 1st 2019). RESULTS: During the pandemic, 46.4% fewer patients visited our urological ED (122 vs 263). There was no significant difference of the mean age or the number of old patients (with 65 or more years old) between the two periods. However, significantly fewer female patients sought emergency urological services during the COVID‐19 pandemic period (32.7% vs. 14.8%, p<0.05). No significant differences were noted between different clinical severity groups under the MTS. In 2019, significantly less patients required hospitalization. The most common reasons for admission, during both periods, were hematuria, renal colic and urinary tract infections (UTI). The authors recognize that the study has several limitations, namely, those inherent to its retrospective nature. CONCLUSION: COVID‐19 significantly influenced people’s urological care‐seeking behaviour. Understanding the present situation is helpful for the prediction of future urological needs. Based on the results of this study, we have reasons to speculate that people’s requirements for urological services might grow explosively in the post‐COVID‐19 period. There should be further studies about the real state of long‐term urological services and the consequences that this pandemic may have in terms of morbimortality not directly related to the virus. url: https://doi.org/10.1111/bju.15109 doi: 10.1111/bju.15109 id: cord-000001-ug7v899j author: Madani, Tariq A title: Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia date: 2001-07-04 words: 2455.0 sentences: 140.0 pages: flesch: 41.0 cache: ./cache/cord-000001-ug7v899j.txt txt: ./txt/cord-000001-ug7v899j.txt summary: title: Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia OBJECTIVE: This retrospective chart review describes the epidemiology and clinical features of 40 patients with culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. CONCLUSION: our results were similar to published data except for the finding that infections were more common in infants and preschool children and that the mortality rate of pneumonia in patients with comorbidities was high. Mycoplasma pneumoniae is a common cause of upper and lower respiratory tract infections. pneumoniae infections in Saudi Arabia is scarce, [8, 9, 10] we wished to study the epidemiology and clinical features of cultureproven infections caused by this organism at this hospital. pneumoniae culture were obtained from patients with upper or lower respiratory tract infections seen as inpatients or in the outpatient or emergency departments. Role of Mycoplasma pneumoniae in acute respiratory-tract infections in Saudi paediatric patients abstract: OBJECTIVE: This retrospective chart review describes the epidemiology and clinical features of 40 patients with culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. METHODS: Patients with positive M. pneumoniae cultures from respiratory specimens from January 1997 through December 1998 were identified through the Microbiology records. Charts of patients were reviewed. RESULTS: 40 patients were identified, 33 (82.5%) of whom required admission. Most infections (92.5%) were community-acquired. The infection affected all age groups but was most common in infants (32.5%) and pre-school children (22.5%). It occurred year-round but was most common in the fall (35%) and spring (30%). More than three-quarters of patients (77.5%) had comorbidities. Twenty-four isolates (60%) were associated with pneumonia, 14 (35%) with upper respiratory tract infections, and 2 (5%) with bronchiolitis. Cough (82.5%), fever (75%), and malaise (58.8%) were the most common symptoms, and crepitations (60%), and wheezes (40%) were the most common signs. Most patients with pneumonia had crepitations (79.2%) but only 25% had bronchial breathing. Immunocompromised patients were more likely than non-immunocompromised patients to present with pneumonia (8/9 versus 16/31, P = 0.05). Of the 24 patients with pneumonia, 14 (58.3%) had uneventful recovery, 4 (16.7%) recovered following some complications, 3 (12.5%) died because of M pneumoniae infection, and 3 (12.5%) died due to underlying comorbidities. The 3 patients who died of M pneumoniae pneumonia had other comorbidities. CONCLUSION: our results were similar to published data except for the finding that infections were more common in infants and preschool children and that the mortality rate of pneumonia in patients with comorbidities was high. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC35282/ doi: 10.1186/1471-2334-1-6 id: cord-264295-7ojvhwb0 author: Maddaloni, Ernesto title: Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II) date: 2020-10-01 words: 4689.0 sentences: 203.0 pages: flesch: 39.0 cache: ./cache/cord-264295-7ojvhwb0.txt txt: ./txt/cord-264295-7ojvhwb0.txt summary: Data collected included: demographic information (age and sex); presence of diabetes (defined as at least one random blood glucose value > 200 mg/dl, or fasting blood glucose > 126 mg/dl, or HbA 1c > 6.5%, or self-reported history of diabetes with ongoing anti-diabetes therapy), type of diabetes (type 1, type 2, other); smoking habits (never, ex, current); prior history of hypertension, dyslipidemia, chronic obstructive pulmonary disease (COPD), heart failure, cardiovascular events (myocardial infarction, percutaneous coronary intervention, coronary artery-bass graft or stroke), malignancy (any neoplasia diagnosed within the last five years or active neoplasia); presenting symptoms of SARS-CoV-2 infection (fever, cough, cold, conjunctivitis, chest pain, dyspnea, nausea, vomiting, diarrhea). Logistic regression models adjusted for age and sex were used to investigate associations of the primary and secondary outcomes with diabetes, and with other risk factors explored in the study, namely hypertension, dyslipidemia, COPD, heart failure, previous cardiovascular events, malignancy and smoking status (never vs. abstract: BACKGROUND: Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and Covid-19 outcomes for patients with or without diabetes, and with or without cardiometabolic multimorbidity. METHODS: We collected and compared data retrospectively from patients hospitalized for Covid-19 with and without diabetes, and with and without cardiometabolic multimorbidity (defined as ≥ two of three risk factors of diabetes, hypertension or dyslipidaemia). Multivariate logistic regression was used to assess the risk of the primary composite outcome (any of mechanical ventilation, admission to an intensive care unit [ICU] or death) in patients with diabetes and in those with cardiometabolic multimorbidity, adjusting for confounders. RESULTS: Of 354 patients enrolled, those with diabetes (n = 81), compared with those without diabetes (n = 273), had characteristics associated with the primary composite outcome that included older age, higher prevalence of hypertension and chronic obstructive pulmonary disease (COPD), higher levels of inflammatory markers and a lower PaO2/FIO2 ratio. The risk of the primary composite outcome in the 277 patients who completed the study as of May 15(th), 2020, was higher in those with diabetes (Adjusted Odds Ratio ((adj)OR) 2.04, 95%CI 1.12–3.73, p = 0.020), hypertension ((adj)OR 2.31, 95%CI: 1.37–3.92, p = 0.002) and COPD ((adj)OR 2.67, 95%CI 1.23–5.80, p = 0.013). Patients with cardiometabolic multimorbidity were at higher risk compared to patients with no cardiometabolic conditions ((adj)OR 3.19 95%CI 1.61–6.34, p = 0.001). The risk for patients with a single cardiometabolic risk factor did not differ with that for patients with no cardiometabolic risk factors ((adj)OR 1.66, 0.90–3.06, (adj)p = 0.10). CONCLUSIONS: Patients with diabetes hospitalized for Covid-19 present with high-risk features. They are at increased risk of adverse outcomes, likely because diabetes clusters with other cardiometabolic conditions. url: https://doi.org/10.1186/s12933-020-01140-2 doi: 10.1186/s12933-020-01140-2 id: cord-317075-zegearxa author: Madenidou, Anastasia-Vasiliki title: Real-life experience of tocilizumab use in COVID-19 patients date: 2020-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/rheumatology/keaa325 doi: 10.1093/rheumatology/keaa325 id: cord-316743-q6gbxghx author: Madhu, S. V. title: Post COVID-19 diabetes care—lessons and challenges date: 2020-06-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32837089/ doi: 10.1007/s13410-020-00831-6 id: cord-350718-jzliir37 author: Madrazo-González, Z. title: Anemia and transfusion therapy: an update date: 2011-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Anemia is one of the most prevalent diseases in the general population and is a very frequently found condition in medical and surgical patients in all medical specialties. A good evaluation of its clinical impact and its therapeutic possibilities is essential. Allogenic blood transfusion is a useful procedure in anemia management, although it has important adverse effects. It is the responsibility of the clinician to know and to take into account all the available alternatives for the treatment of anemia. Blood transfusions, erythropoiesis-stimulating agents, iron therapy (oral and endovenous) and other therapeutic alternatives must be rationally used, in accordance with the currently available clinical evidence. This review article summarizes some epidemiological characteristics of anemia, its clinical evaluation and the main therapeutic possibilities based on the present knowledge, placing special emphasis on the critically ill patient. url: https://api.elsevier.com/content/article/pii/S2173572711700078 doi: 10.1016/s2173-5727(11)70007-8 id: cord-286237-x6dr6rsh author: Maes, Bastiaan title: Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-03 words: 11252.0 sentences: 579.0 pages: flesch: 49.0 cache: ./cache/cord-286237-x6dr6rsh.txt txt: ./txt/cord-286237-x6dr6rsh.txt summary: -mechanical ventilation > 24 h at randomization -clinical frailty scale above 3 -active bacterial or fungal infection -unlikely to survive beyond 48h -neutrophil count below 1500 cells/microliter -platelets below 50.000/microliter -Patients enrolled in another investigational drug study -patients on high dose systemic steroids (> 8 mg methylprednisolone or equivalent for more than 1 month) for COVID-19 unrelated disorder -patients on immunosuppressant or immunomodulatory drugs -patients on current anti-IL1 or anti-IL6 treatment -signs of active tuberculosis -serum transaminase levels >5 times upper limit of normal, unless there are clear signs of cytokine release syndrome defined by LDH >300 IU/L and ferritin >700 ng/ml -history of (non-iatrogenic) bowel perforation or diverticulitis -Pregnant or breastfeeding females (all female subjects deemed of childbearing potential by the investigator must have negative pregnancy test at screening) 5.2.1. abstract: OBJECTIVES: The purpose of this study is to test the safety and effectiveness of individually or simultaneously blocking IL-6, IL-6 receptor and IL-1 versus standard of care on blood oxygenation and systemic cytokine release syndrome in patients with COVID-19 coronavirus infection and acute hypoxic respiratory failure and systemic cytokine release syndrome. TRIAL DESIGN: A phase 3 prospective, multi-center, interventional, open label, 6-arm 2x2 factorial design study. PARTICIPANTS: Subjects will be recruited at the specialized COVID-19 wards and/or ICUs at 16 Belgian participating hospitals. Only adult (≥18y old) patients will be recruited with recent (≤16 days) COVID-19 infection and acute hypoxia (defined as PaO2/FiO2 below 350mmHg or PaO2/FiO2 below 280 on supplemental oxygen and immediately requiring high flow oxygen device or mechanical ventilation) and signs of systemic cytokine release syndrome characterized by high serum ferritin, or high D-dimers, or high LDH or deep lymphopenia or a combination of those, who have not been on mechanical ventilation for more than 24 hours before randomisation. Patients should have had a chest X-ray and/or CT scan showing bilateral infiltrates within the last 2 days before randomisation. Patients with active bacterial or fungal infection will be excluded. INTERVENTION AND COMPARATOR: Patients will be randomized to 1 of 5 experimental arms versus usual care. The experimental arms consist of Anakinra alone (anti-IL-1 binding the IL-1 receptor), Siltuximab alone (anti-IL-6 chimeric antibody), a combination of Siltuximab and Anakinra, Tocilizumab alone (humanised anti-IL-6 receptor antibody) or a combination of Anakinra with Tocilizumab in addition to standard care. Patients treated with Anakinra will receive a daily subcutaneous injection of 100mg for a maximum of 28 days or until hospital discharge, whichever comes first. Siltuximab (11mg/kg) or Tocilizumab (8mg/kg, with a maximum dose of 800mg) are administered as a single intravenous injection immediately after randomization. MAIN OUTCOMES: The primary end point is the time to clinical improvement defined as the time from randomization to either an improvement of two points on a six-category ordinal scale measured daily till day 28 or discharge from the hospital or death. This ordinal scale is composed of (1) Death; (2) Hospitalized, on invasive mechanical ventilation or ECMO; (3) Hospitalized, on non-invasive ventilation or high flow oxygen devices; (4) Hospitalized, requiring supplemental oxygen; (5) Hospitalized, not requiring supplemental oxygen; (6) Not hospitalized. RANDOMISATION: Patients will be randomized using an Interactive Web Response System (REDCap). A 2x2 factorial design was selected with a 2:1 randomization regarding the IL-1 blockade (Anakinra) and a 1:2 randomization regarding the IL-6 blockade (Siltuximab and Tocilizumab). BLINDING (MASKING): In this open-label trial neither participants, caregivers, nor those assessing the outcomes are blinded to group assignment. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): A total of 342 participants will be enrolled: 76 patients will receive usual care, 76 patients will receive Siltuximab alone, 76 patients will receive Tocilizumab alone, 38 will receive Anakinra alone, 38 patients will receive Anakinra and Siltuximab and 38 patients will receive Anakinra and Tocilizumab. TRIAL STATUS: COV-AID protocol version 3.0 (15 Apr 2020). Participant recruitment is ongoing and started on April 4(th) 2020. Given the current decline of the COVID-19 pandemic in Belgium, it is difficult to anticipate the rate of participant recruitment. TRIAL REGISTRATION: The trial was registered on Clinical Trials.gov on April 1st, 2020 (ClinicalTrials.gov Identifier: NCT04330638) and on EudraCT on April 3rd 2020 (Identifier: 2020-001500-41). FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://doi.org/10.1186/s13063-020-04453-5 doi: 10.1186/s13063-020-04453-5 id: cord-029848-dj5xqlz1 author: Mahajan, Vidushi title: Using Telemedicine During the COVID-19 Pandemic date: 2020-05-14 words: 2134.0 sentences: 122.0 pages: flesch: 49.0 cache: ./cache/cord-029848-dj5xqlz1.txt txt: ./txt/cord-029848-dj5xqlz1.txt summary: Telemedicine is defined as the delivery of health care services, where distance is a critical factor, by all healthcare professionals using information or communication technology. Telemedicine aims to ensure equitable services to everyone, is costeffective, provides safety to both patient and doctors during pandemics, and offers timely and faster care. Telemedicine can be classified on the basis of mode of communication as (i) audio, video or text-based (video mode is preferred as it allows limited examination as well); (ii) timing of information transmitted as real time or asynchronous exchange; (iii) purpose of consult as first time or follow up (in non-emergent cases or emergency consultation); and (iv) according to individuals involved as patient to medical practitioner, caregiver to medical practitioner, medical practitioner to medical practitioner or health worker to medical practitioner [2] . Doctors should avoid giving advice in such cases and the patient must be referred for an urgent in-person visit to the nearest hospital. abstract: Telemedicine is the delivery of health care services using information or communication technology. In the current pandemic scenario, telemedicine can supplement health-care delivery in the absence of in-person visit. The Government of India has recently launched the e-sanjeevani OPD, a National teleconsultation service, which has been adopted by many state governments as mandatory for health-care providers. With Indian Medical Association issuing an advisory against the use of telemedicine except in few situations, a lot of confusion exists in the mind of a pediatrician. Despite the uncertain situation, we have to remember that other diseases shall not stall in the face of a pandemic. Since telemedicine is an evolving subject, training of medical professionals, clear guidelines and good quality internet service systems will go a long way in increasing the acceptability of telemedicine in the Indian population. We herein discuss issues related to using telemedicine during the SARS-CoV-2 pandemic. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387251/ doi: 10.1007/s13312-020-1895-6 id: cord-288158-6gicgsj8 author: Mahammedi, Abdelkader title: Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study date: 2020-05-21 words: 1099.0 sentences: 76.0 pages: flesch: 46.0 cache: ./cache/cord-288158-6gicgsj8.txt txt: ./txt/cord-288158-6gicgsj8.txt summary: title: Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study Of 725 consecutive hospitalized patients with coronavirus disease 2019, 108 (15%) had acute neurologic symptoms necessitating neurologic imaging. Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study E271 10 had acute ischemic infarcts and two had intracranial hemorrhage. The main neurologic imaging hallmark was acute ischemic infarcts, which were present in 34 of the 108 patients (31%) (30 [28%] on CT scans and four [20%] on MRI scans). Our study demonstrated that the neurologic imaging features of hospitalized patients with COVID-19 were variable, without a specific pattern but dominated by acute ischemic infarcts and intracranial hemorrhages. Currently, we have a poor mechanistic understanding of the neurologic symptoms in patients with COVID-19, whether these are arising from critical illness or from direct central nervous system invasion of severe acute respiratory syndrome coronavirus 2 (10). abstract: Of 725 consecutive hospitalized patients with coronavirus disease 2019, 108 (15%) had acute neurologic symptoms necessitating neurologic imaging. url: https://doi.org/10.1148/radiol.2020201933 doi: 10.1148/radiol.2020201933 id: cord-340204-3gm58qza author: Mahmoodpoor, Ata title: Management of Critically Ill Patients with COVID-19: What We Learned and What We Do date: 2020-06-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There are many unknown questions and puzzle pieces that should describe the clinical course of COVID-19 and its complications, especially ARDS. We provide the initial immediate surge response to allow every patient in need of an ICU bed to receive one. Till our knowledge is improved, the most important intervention in the treatment of critically ill patients with COVID-19 seems to be the level of standard care and appropriate and early diagnosis and treatment. It seems that each center should have its protocol on the management of critically ill COVID-19 patients regarding prevention, diagnosis, and treatment. This treatment should now be performed regardless of the reason which lies behind the pathophysiology of this disease, which is yet unknown. In this report, we share our experience in the management of critically ill COVID-19 patients during the 2 months in our intensive care unit. url: https://www.ncbi.nlm.nih.gov/pubmed/32944565/ doi: 10.5812/aapm.104900 id: cord-300458-jeuwaj50 author: Maisch, Bernhard title: COVID-19—What we know and what we need to know: There are more questions than answers date: 2020-04-23 words: 1156.0 sentences: 73.0 pages: flesch: 57.0 cache: ./cache/cord-300458-jeuwaj50.txt txt: ./txt/cord-300458-jeuwaj50.txt summary: COVID-19-What we know and what we need to know: There are more questions than answers This collection of short statements from the editors of HERZ/Cardiovascular Diseases is a strong signal to the readers of our journal in critical times. But we also fear that with a low herd immunity a second wave of infection might follow, since no proven antiviral treatment for COVID-19 exists and vaccination is not yet available [3] . Pulmonology demonstrates with every ventilated patient that COVID-19 is a potentially lethal lung disease. The first reported Chinese patient with suspected myocarditis from SARS-CoV-2 was treated with ventilation, methylprednisolone, i.v. immunoglobulins and inotropics and survived [4] . A total of 55 authors (!) have described in an observational study with 66 COVID-19 patients without a control group a beneficial effect in the New England Journal of Medicine [5] . 2020) compassionate use of remdesivir for patients with severe Covid-19 abstract: nan url: https://doi.org/10.1007/s00059-020-04929-9 doi: 10.1007/s00059-020-04929-9 id: cord-264449-p3tgjuj4 author: Majumdar, PK title: Orthopaedic Surgery in Times of COVID-19 in India date: 2020-07-17 words: 1734.0 sentences: 92.0 pages: flesch: 45.0 cache: ./cache/cord-264449-p3tgjuj4.txt txt: ./txt/cord-264449-p3tgjuj4.txt summary: The fear of asymptomatic carriers in patients and colleagues should not weigh on the decision to operate but should be evaluated by the urgency of the procedure; existing and anticipated COVID-19 cases in the hospital and region; availability of PPE, beds and staff; and finally, age and health of the patient. In one of Indonesian public hospitals, Orthopaedic surgeons are only allowed to perform surgeries on emergency, malignancy, and infection cases, whereas elective surgeries shall be postponed indefinitely. To lessen the number of visits, some Orthopaedic surgeons extend the length of post-operative joint replacement stay of their patients up to 10-14 days to receive the multidisciplinary care, including rehabilitation and wound care. Evidence of COVID-19 transmission from asymptomatic individuals 1 brings challenges to orthopaedic practice in terms of nosocomial transmission, isolation and cohorting requirements and increased post operative complications in undetected individuals. Pre-and post-operative screening in limited-term elective cancer surgery patients during the COVID-19 pandemic abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32983394/ doi: 10.5704/moj.2007.005 id: cord-283738-v3h7p297 author: Makar, Michael title: Gastrointestinal Findings in a Patient With COVID-19 date: 2020-06-11 words: 1428.0 sentences: 103.0 pages: flesch: 52.0 cache: ./cache/cord-283738-v3h7p297.txt txt: ./txt/cord-283738-v3h7p297.txt summary: The novel coronavirus (severe acute respiratory syndrome coronavirus 2) that causes coronavirus disease 2019 was discovered in December 2019 in Wuhan, China, and has rapidly spread across the world becoming a pandemic and disrupting societies, economies, and public health. We present a patient diagnosed with coronavirus who presented with several days of GI symptoms and discuss the relevance of GI disease and liver injury in these patients. 9 We present a patient diagnosed with COVID-19 who presented with several days of GI symptoms and discuss the relevance of GI disease and liver injury in these patients. 2 Several studies have reported that patients may initially present with GI symptoms such as diarrhea and nausea a few days before developing pulmonary manifestations. We present a patient with 3 days of nausea, vomiting, and diarrhea before developing fever and acute respiratory distress syndrome from COVID-19. Digestive symptoms in COVID-19 patients with mild disease severity: Clinical presentation, stool viral RNA testing, and outcomes abstract: The novel coronavirus (severe acute respiratory syndrome coronavirus 2) that causes coronavirus disease 2019 was discovered in December 2019 in Wuhan, China, and has rapidly spread across the world becoming a pandemic and disrupting societies, economies, and public health. Digestive symptoms and gastrointestinal (GI) manifestations are increasingly being reported in patients with the virus. There is also a growing body of evidence to suggest that liver injury is frequent. We present a patient diagnosed with coronavirus who presented with several days of GI symptoms and discuss the relevance of GI disease and liver injury in these patients. url: https://doi.org/10.14309/crj.0000000000000392 doi: 10.14309/crj.0000000000000392 id: cord-323538-9dlr6kqh author: Malard, Florent title: COVID-19 outcomes in patients with hematologic disease date: 2020-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32376969/ doi: 10.1038/s41409-020-0931-4 id: cord-025170-dtbm4ue1 author: Malbrain, Manu L. N. G. title: Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA) date: 2020-05-24 words: 9180.0 sentences: 454.0 pages: flesch: 39.0 cache: ./cache/cord-025170-dtbm4ue1.txt txt: ./txt/cord-025170-dtbm4ue1.txt summary: Resuscitation fluids are used to correct an intravascular volume deficit or acute hypovolemia; replacement solutions are prescribed to correct existing or developing deficits that cannot be compensated by oral intake alone [6] ; maintenance solutions are indicated in hemodynamically stable patients that are not able/allowed to drink water in order to cover their daily requirements of water and electrolytes [10, 11] . Despite the unexpectedly low volume of crystalloids, the authors found a small difference in the primary outcome, i.e., the incidence of major adverse kidney events within 30 days (composite of death, new renal replacement therapy or persistent renal dysfunction) in favor of balance solutions. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: The SPLIT randomized clinical trial Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial abstract: Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid administration as drug diluent or to preserve catheter patency, i.e., fluid creep, should also be considered. As for antibiotics, intravenous fluid administration should follow the four Ds: drug, dosing, duration, de-escalation. Among crystalloids, balanced solutions limit acid–base alterations and chloride load and should be preferred, as this likely prevents renal dysfunction. Among colloids, albumin, the only available natural colloid, may have beneficial effects. The last decade has seen growing interest in the potential harms related to fluid overloading. In the perioperative setting, appropriate fluid management that maintains adequate organ perfusion while limiting fluid administration should represent the standard of care. Protocols including a restrictive continuous fluid administration alongside bolus administration to achieve hemodynamic targets have been proposed. A similar approach should be considered also for critically ill patients, in whom increased endothelial permeability makes this strategy more relevant. Active de-escalation protocols may be necessary in a later phase. The R.O.S.E. conceptual model (Resuscitation, Optimization, Stabilization, Evacuation) summarizes accurately a dynamic approach to fluid therapy, maximizing benefits and minimizing harms. Even in specific categories of critically ill patients, i.e., with trauma or burns, fluid therapy should be carefully applied, considering the importance of their specific aims; maintaining peripheral oxygen delivery, while avoiding the consequences of fluid overload. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245999/ doi: 10.1186/s13613-020-00679-3 id: cord-264504-nnvof29x author: Malentacchi, Maria title: Concomitant brain arterial and venous thrombosis in a COVID‐19 patient date: 2020-06-05 words: 822.0 sentences: 53.0 pages: flesch: 41.0 cache: ./cache/cord-264504-nnvof29x.txt txt: ./txt/cord-264504-nnvof29x.txt summary: COVID‐19 infection can cause a severe pneumonia which, in some cases, can lead to admission in intensive care unit for respiratory support.(1) In severe cases, systemic thrombotic complication has been described, including cerebrovascular disease (5.7‐23% of cases).(2,3) COVID-19 infection can cause a severe pneumonia which, in some cases, can lead to admission in intensive care unit for respiratory support. Our case underlines that one of the main causes for clinical deterioration and death during COVID-19 infection is coagulopathy that can involve both arterial and venous systems. [2] [3] 5 As far as we know, the simultaneous occurrence of venous and arterial thrombosis of the brain has not been described yet, and it could represent an important cause of neurological impairment in patients affected by COVID-19: prompt execution of neuroradiological examination of the Accepted Article parenchyma and post-contrast imaging of both arterial and venous systems could allow to perform a correct diagnosis and to apply the more appropriate treatment strategy. abstract: COVID‐19 infection can cause a severe pneumonia which, in some cases, can lead to admission in intensive care unit for respiratory support.(1) In severe cases, systemic thrombotic complication has been described, including cerebrovascular disease (5.7‐23% of cases).(2,3) url: https://doi.org/10.1111/ene.14380 doi: 10.1111/ene.14380 id: cord-337088-xxyhmn1t author: Malhotra, Naveen title: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement regarding COVID-19 date: 2020-03-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.4103/ija.ija_288_20 doi: 10.4103/ija.ija_288_20 id: cord-311682-npi03i7q author: Malicki, J title: Impact of COVID-19 on the performance of a radiation oncology department at a major comprehensive cancer centre in Poland during the first ten weeks of the epidemic date: 2020-08-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The outbreak of SARS-CoV-2 coronavirus rapidly altered radiotherapy service delivery around the world. Aim. The main objective of this study was to assess the impact of precautionary measures implemented in response to the COVID-19 pandemic on the performance of a radiation oncology departments and on mitigation the risk of COVID-19 contagion between and among patients and staff. Methods. The study period was from March 15 until May 22, 2020. We evaluated total number of patients irradiated and those who initiated treatments, taking into account tumours localisations. We assessed the relationship of potential risk of contagion with patients’ domiciles locations in regions with high number of COVID19 case. Results and conclusions. The number of patients treated with radiotherapy during the study period decreased due to precautionary measures. After five weeks, the number of radiotherapy treatments began to increase. Just over half of the radiotherapy patients (53.5%) treated at the GPCC reside in the city of Poznan or in one of the ten surrounding counties where COVID19 incidence was low and reached at the end of the study period cumulative number of cases n = 204. The precautionary measures were effective qRT-PCR tests were performed in 1545 individuals (patients and hospital staff) revealing four staff members and none patient with a positive PCR result. Immunoglobulin testing was performed in 1132 individuals (patients and hospital staff). A total of 63 individuals were positive for antibodies. url: https://www.sciencedirect.com/science/article/pii/S1507136720301097?v=s5 doi: 10.1016/j.rpor.2020.08.001 id: cord-350325-vu8v9epr author: Malih, Narges title: Unexpected Presentation of COVID-19 in a 38-Year-Old Male Patient: A Case Report date: 2020-07-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We presently report the case of COVID-19 in a 38-year-old male who had come to the primary health care clinic of Shahid Beheshti University of Medical Sciences, which specializes in the COVID-19 epidemic. He reported having fatigue, myalgia, fever, rash, and loss of taste and smell. The physical findings were maculopapular rash over his trunk, inguinal regions, and left arm, erythema of larynx with an aphthous lesion on left tonsil, he did not have a fever, and respiratory distress symptoms. There were no changes regarding COVID-19 in the spiral lung CT scan. However, the result of PCR for COVID-19 RNA was positive. url: https://doi.org/10.1159/000509994 doi: 10.1159/000509994 id: cord-291624-fod0eyuj author: Malone, Robert W. title: COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms date: 2020-06-22 words: 6496.0 sentences: 354.0 pages: flesch: 43.0 cache: ./cache/cord-291624-fod0eyuj.txt txt: ./txt/cord-291624-fod0eyuj.txt summary: We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H (2) activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release. Patients with COVID-19 disease can present with a range of mild to severe non-speci c clinical signs and symptoms which develop two to fourteen days after exposure to SARS-CoV-2. The most likely mechanisms of actions include: via antiviral activity, via novel human targets, or via the on-target mechanism described in the current FDA market authorization-famotidine is a histamine receptor H 2 antagonist (and inverse agonist). To assess the possibility that famotidine may inhibit SARS-CoV-2 infection by other routes, a Vero E6 cell-based assay was performed to compare median tissue culture infectious doses (TCID50/mL) of famotidine, remdesivir, and hydroxychloroquine ( Figure 2 ). In both of these studies, the observed non-in ammatory edema in early-stage COVID-19 pulmonary disease is consistent with histamine release by mast cells. abstract: SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure. We explore several plausible avenues of activity including antiviral and host-mediated actions. We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H (2) activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release. url: https://doi.org/10.21203/rs.3.rs-30934/v2 doi: 10.21203/rs.3.rs-30934/v2 id: cord-314088-ktj17dvq author: Mancini, Francesca title: Personalized care management for persons with Parkinson's disease: A telenursing solution date: 2020-08-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Poor recognition and inadequate treatment of motor and non-motor symptoms negatively impact on the quality of life of persons with Parkinson's Disease (PD). Furthermore, failure to incorporate timely detection and management of symptoms increases the risk of partially avoidable complications. A promising approach to overcome these pitfalls is telenursing, which entails proactive care delivery by a PD Nurse Specialist (PDNS) through telephone contacts. We hypothesized that adding telenursing to usual care could fill a gap in currently available services, including offering patients easy accessibility to a nurse with specific expertise in PD. We explored this hypothesis by prospectively assessing the effects of a telenursing intervention on motor and non-motor symptoms in a patient with PD. During a threemonth intervention period which comprised 13 telephone contacts, the patient reported a remarkable reduction in number of falls, from 99 falls per three months to 3 falls per three months; and a reduction in non-motor symptoms. The main working mechanism was presumably rather indirect and mediated via alleviation of anxiety, achieved by the individually tailored information and problem-solving strategies provided by the PDNS. Our observations should encourage large-scale evaluations to assess the long-term effectiveness and cost-effectiveness of telenursing interventions in persons with PD. url: https://www.sciencedirect.com/science/article/pii/S2590112520300384?v=s5 doi: 10.1016/j.prdoa.2020.100070 id: cord-332788-8lq9qygn author: Manda, Sudhir title: Feasibility of Long-Term Proteasome Inhibition in Multiple Myeloma by In-Class Transition from Bortezomib to Ixazomib date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The ongoing US MM-6 study is investigating in-class transition (iCT) from parenteral bortezomib-based induction to all-oral ixazomib-lenalidomide-dexamethasone (ixazomib-Rd) with the aim of increasing proteasome inhibitor (PI)-based treatment adherence/duration while maintaining quality of life (QoL) and improving outcomes. PATIENTS AND METHODS: US community sites are enrolling non-transplant-eligible newly diagnosed multiple myeloma (MM) patients with no evidence of progressive disease after 3 cycles of bortezomib-based therapy to receive ixazomib-Rd (up to 39 cycles or until progression/toxicity). Patients use mobile/wearable digital devices to collect actigraphy (activity/sleep) data and electronically complete QoL/treatment satisfaction/medication adherence questionnaires. Primary endpoint: progression-free survival (PFS); key secondary endpoints include response rates and therapy duration. RESULTS: At data cutoff, 84 patients had been treated (median age 73 years; 44% ≥ 75 years; 49% male; 15% black/African American; 10% Hispanic/Latino); 62% of patients remain on therapy. Mean duration of total PI therapy was 10.1 months and of ixazomib-Rd was 7.3 months. With 8 months median follow-up, 12-month PFS rate was 86% (95% confidence interval, 73–93) from both the start of bortezomib-based treatment and the start of ixazomib-Rd. Overall response rate was 62% (complete response [CR], 4%; very good partial response [VGPR], 25%; partial response [PR], 33%) after bortezomib-based induction and 70% (CR, 26%; VGPR, 29%; PR, 15%) after iCT. The ixazomib-Rd safety profile was consistent with previous clinical trial data. QoL/treatment satisfaction were maintained. CONCLUSION: US MM-6 patients are representative of the real-world US MM population; iCT may permit prolonged PI-based therapy with promising efficacy, without impacting patients’ QoL/treatment satisfaction. url: https://www.sciencedirect.com/science/article/pii/S2152265020303359?v=s5 doi: 10.1016/j.clml.2020.06.024 id: cord-349439-3z0b77r5 author: Mandal, Amitabha title: A Systematic Review on Tracheostomy in COVID-19 Patients: Current Guidelines and Safety Measures date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: At this moment the world is fighting with COVID-19 pandemic. Because of increasing number of critical cases, the ICU admissions are also increasing and overwhelming the hospital. These group of patients often required Tracheostomy for proper management and ventilation. As Surgeons we often required to examine and perform procedures in head and neck patients and are in high risk of exposure to aerosol and droplet contamination. We did a literature search for research regarding tracheostomy and its post procedure care during the ongoing COVID-19 pandemic. In this review various international guidelines and sources were put together, and we aim to summarize in a systematic way the available recommendations: indications, timing, technique and safety measures for tracheostomy for COVID-19 patients, from all over the world. url: https://www.ncbi.nlm.nih.gov/pubmed/33014752/ doi: 10.1007/s12070-020-02152-w id: cord-260630-vvpzp73r author: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 words: 2623.0 sentences: 120.0 pages: flesch: 52.0 cache: ./cache/cord-260630-vvpzp73r.txt txt: ./txt/cord-260630-vvpzp73r.txt summary: In this issue of Clinical Infectious Diseases, there are 2 articles that provide us with some insight into the various etiologic agents that can cause acute respiratory tract infection (ARTI) in general practice patients in The Netherlands [1] and into the significance of the human metapneumovirus (hMPV) in patients with community-acquired pneumonia (CAP) and exacerbations of chronic obstructive pulmonary disease (COPD) in Quebec, Canada [2] . The objectives of the Dutch study were to estimate the incidence of influenza-like illnesses (ILIs) and of other ARTIs in patients visiting their general practitioners (to determine the etiologic agents) and to test the hypothesis that asymptomatic persons with subclinical infection may act as sources of transmission [1] . Nose and throat swab specimens were obtained from case patients and control subjects, and viral cultures and PCR tests were performed for detection of adenovirus, coronavirus, enterovirus, hMPV, influenza virus, parainfluenza virus, rhinovirus, and respiratory syncytial virus (RSV), as well as for Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Chlamydophila psittaci. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/16028159/ doi: 10.1086/432019 id: cord-292094-vmsdhccp author: Mandell, Lionel A. title: Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults date: 2007-03-01 words: 28389.0 sentences: 1424.0 pages: flesch: 37.0 cache: ./cache/cord-292094-vmsdhccp.txt txt: ./txt/cord-292094-vmsdhccp.txt summary: Severity-of-illness scores, such as the CURB-65 criteria (confusion, uremia, respiratory rate, low blood pressure, age 65 years or greater), or prognostic models, such as the Pneumonia Severity Index (PSI), can be used to identify patients with CAP who may be candidates for outpatient treatment. A respiratory fluoroquinolone should be used for penicillin-allergic patients.) Increasing resistance rates have suggested that empirical therapy with a macrolide alone can be used only for the treat-ment of carefully selected hospitalized patients with nonsevere disease and without risk factors for infection with drug-resistant pathogens. Advantages include the high specificity, the ability of some assays to distinguish between influenza A and B, the rapidity with which the results can be obtained, the possibly reduced use of antibacterial agents, and the utility of establishing this diagnosis for epidemiologic purposes, especially in hospitalized patients who may require infection control precautions. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/17278083/ doi: 10.1086/511159 id: cord-299024-jkqdzt87 author: Mangner, Norman title: Paraneoplastic syndrome and SARS-CoV-2 – incremental effect of two thrombogenic conditions? date: 2020-10-21 words: 1071.0 sentences: 65.0 pages: flesch: 40.0 cache: ./cache/cord-299024-jkqdzt87.txt txt: ./txt/cord-299024-jkqdzt87.txt summary: We present the case of a patient with a non-bacterial thrombotic aortic valve endocarditis experiencing severe thromboembolic complications and an acute right internal carotid artery occlusion in the context of a paraneoplastic syndrome and an asymptomatic SARS-CoV-2 infection, despite treatment with different and overlapping anticoagulant medication. This case describes a patient with non-bacterial thrombotic aortic valve endocarditis that developed despite treatment with a factor-Xa-inhibitor and who subsequently suffered a myocardial infarction and two strokes within a short period of time in the context of a paraneoplastic syndrome and asymptomatic SARS-CoV-2 infection. Paraneoplastic syndromes are often linked to increased thrombogenicity; however, non-bacterial thrombotic aortic valve endocarditis is rare even in the situation of cancer. 3 This case highlights the many-sided effects of paraneoplastic syndromes and SARS-CoV-2 infection in patients being already at increased risk for thrombotic complications due to underlying disease. abstract: We present the case of a patient with a non-bacterial thrombotic aortic valve endocarditis experiencing severe thromboembolic complications and an acute right internal carotid artery occlusion in the context of a paraneoplastic syndrome and an asymptomatic SARS-CoV-2 infection, despite treatment with different and overlapping anticoagulant medication. Patients with increased thrombogenicity due to an underlying disease might be at increased risk for thrombotic events during a SARS-CoV-2 infection. url: https://www.ncbi.nlm.nih.gov/pubmed/33106785/ doi: 10.1016/j.cjco.2020.10.010 id: cord-341202-1pg7rq2d author: Manicone, Francesca title: The last bed dilemma burns out COVID-19 triage: a viewpoint from Medical and Law students date: 2020-08-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2666479820301828 doi: 10.1016/j.lpmfor.2020.08.004 id: cord-274008-p3st70u3 author: Mann, E. R. title: Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis date: 2020-06-16 words: 6004.0 sentences: 359.0 pages: flesch: 49.0 cache: ./cache/cord-274008-p3st70u3.txt txt: ./txt/cord-274008-p3st70u3.txt summary: Here we report the outcome of a longitudinal immune profiling study in hospitalised patients during the peak of the COVID-19 pandemic in the UK and show the relationship between immune responses and severity of the clinical presentation. Although, as reported previously 4 , a higher neutrophil to lymphocyte ratio (NLR) on hospital admission was observed in those patients whose disease trajectory was ultimately severe, whereas there were no appreciable differences observed in monocytes (figure 1A, 1B and table 1). Longitudinal analysis revealed that in the majority of patients (70%) (irrespective of severity) T cell frequencies in whole blood increased prior to hospital discharge, while neutrophil frequencies reciprocally decreased (figure 1E). Severe COVID-19, on the other hand, was associated with monocytes displaying increased expression of the cell cycle marker, Ki67 (normally <5% in healthy peripheral blood), irrespective of whether monocytes were stimulated or not (figure 3C and appendix 6C), which strongly correlated with hospital data for CRP (figure 3C). abstract: Background The pathogenesis of COVID-19, caused by a novel strain of coronavirus (SARS-CoV-2), involves a complex host-virus interaction and is characterised by an exaggerated immune response, the specific components of which are poorly understood. Here we report the outcome of a longitudinal immune profiling study in hospitalised patients during the peak of the COVID-19 pandemic in the UK and show the relationship between immune responses and severity of the clinical presentation. Methods The Coronavirus Immune Response and Clinical Outcomes (CIRCO) study was conducted at four hospitals in Greater Manchester. Patients with SARS-CoV-2 infection, recruited as close to admission as possible, provided peripheral blood samples at enrolment and sequentially thereafter. Fresh samples were assessed for immune cells and proteins in whole blood and serum. Some samples were also stimulated for 3 hours with LPS and analysed for intracellular proteins. Results were stratified based on patient-level data including severity of symptoms and date of reported symptom onset. Findings Longitudinal analysis showed a very high neutrophil to T cell ratio and abnormal activation of monocytes in the blood, which displayed high levels of the cell cycle marker, Ki67 and low COX-2. These properties all reverted in patient with good outcome. Unexpectedly, multiple aspects of inflammation were diminished as patients progressed in severity and time, even in ITU patients not recovering. Interpretation This is the first detailed longitudinal analysis of COVID-19 patients of varying severity and outcome, revealing common features and aspects that track with severity. Patients destined for a severe outcome can be identified at admission when still displaying mild-moderate symptoms. We provide clues concerning pathogenesis that should influence clinical trials and therapeutics. Targeting pathways involved in neutrophil and monocyte release from the bone marrow should be tested in patients with COVID-19. Funding: The Kennedy Trust for Rheumatology Research, The Wellcome Trust, The Royal Society, The BBSRC, National Institute for Health Research (NIHR) Biomedical Research Centres (BRC). url: https://doi.org/10.1101/2020.06.13.20127605 doi: 10.1101/2020.06.13.20127605 id: cord-010461-un9pls28 author: Manohar, Sujal title: A Three-part Quality Improvement Initiative to Increase Patient Satisfaction and Reduce Appointment Time date: 2020-03-09 words: 3192.0 sentences: 207.0 pages: flesch: 53.0 cache: ./cache/cord-010461-un9pls28.txt txt: ./txt/cord-010461-un9pls28.txt summary: METHODS: PediPlace introduced 3 interventions: improved patient tracking to measure timing on the electronic health record interface, elimination of script repetition between medical assistants and providers, and patient art kits. PediPlace implemented 3 interventions and measured the impact by tracking survey responses and total appointment length. PediPlace compared appointment lengths between July-December 2018 and January-June 2019, dividing the year into 2 parts before and after 2 of the QI interventions (revising MA and provider scripts and improving tracking). The clinic studied how different factors, such as patient age, patient ethnicity, provider, and time of year, impacted the total appointment length. PediPlace did not examine time spent during each part of the visit, such as "time with provider" or "time waiting for immunizations." This analysis is a potential area for future data collection because even a 5-minute difference in appointment length can alter patient perceptions of the healthcare experience. abstract: INTRODUCTION: PediPlace, a busy pediatric not-for-profit clinic in Lewisville, Tex., struggles with prolonged patient wait times. This quality improvement (QI) project aimed to reduce appointment lengths and improve the patient experience. METHODS: PediPlace introduced 3 interventions: improved patient tracking to measure timing on the electronic health record interface, elimination of script repetition between medical assistants and providers, and patient art kits. RESULTS: From over 2,000 surveys indicated that patients were more satisfied; the percentage of negative survey comments decreased from 20% in 2017 and 2018 to under 10% in 2019. The overall rating of the clinic rose from 3.8 to 4.75 (on a scale of 1–5) after QI interventions as well. The number of patients not checked out declined from 49 errors in October–December 2018 to 25 errors in January–March 2019, indicating that this part of the initiative was initially successful. However, subsequent months experienced higher error rates. Analysis of over 20,000 appointments from June 2018 to July 2019 showed that appointment length did not change after interventions. CONCLUSIONS: There was no difference in appointment lengths between Hispanic/Latino patients and other patients, and an encouraging finding that suggests PediPlace providers are effective bilingual communicators. Furthermore, anecdotal evidence indicated that the art kits were positively received. The interventions appeared to improve the patient experience but did not impact appointment length. PediPlace plans to continue QI initiatives in the future. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190244/ doi: 10.1097/pq9.0000000000000277 id: cord-258548-1u7v1nlr author: Mansueto, Gelsomina title: Can COVID 2019 disease induces a specific cardiovascular damage or it exacerbates pre-existing cardiovascular diseases? date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A novel coronavirus SARS-CoV-2 causes acute respiratory distress syndrome (ARDS) with cardiovascular and multiple organ failure till death. The main mechanisms of virus internalization and interaction with the host are down-regulation or upregulation of the ACE2 receptor, the surface glycoprotein competition mechanism for the binding of porphyrin to iron in heme formation as well as interference with the immune system. The interference on renin–angiotensin–aldosterone system (RAAS) activation, heme formation, and the immune response is responsible for infection diffusion, endothelial dysfunction, vasoconstriction, oxidative damage and releasing of inflammatory mediators. The main pathological findings are bilateral interstitial pneumonia with diffuse alveolar damage (DAD). Because ACE receptor is also present in the endothelium of other districts as well as in different cell types, and as porphyrins are transporters in the blood and other biological liquids of iron forming heme, which is important in the assembly of the hemoglobin, myoglobin and the cytochromes, multiorgan damage occurs both primitive and secondary to lung damage. More relevantly, myocarditis, acute myocardial infarction, thromboembolism, and disseminated intravasal coagulation (DIC) are described as complications in patients with poor outcome. Here, we investigated the role of SARSCoV-2 on the cardiovascular system and in patients with cardiovascular comorbidities, and possible drug interference on the heart. url: https://api.elsevier.com/content/article/pii/S0344033820314795 doi: 10.1016/j.prp.2020.153086 id: cord-013148-qbxbndsl author: Manzano-Nunez, Ramiro title: Outcomes and management approaches of resuscitative endovascular balloon occlusion of the aorta based on the income of countries date: 2020-10-12 words: 3931.0 sentences: 192.0 pages: flesch: 45.0 cache: ./cache/cord-013148-qbxbndsl.txt txt: ./txt/cord-013148-qbxbndsl.txt summary: Propensity score matching extracted 1:1 matched pairs of subjects who were from an LMIC or a HIC based on age, gender, the presence of pupillary response on admission, impeding hypotension (SBP ≤ 80), trauma mechanism, ISS, the necessity of CPR on arrival, the location of REBOA insertion (emergency room or operating room) and the amount of PRBCs transfused in the first 24 h. CONCLUSION: There is considerable variation in the management practices of REBOA and the outcomes associated with this intervention between HICs and LMICs. Although we found significant differences in multiorgan and respiratory failure rates, there were no differences in the risk-adjusted odds of mortality between the groups analyzed. In order to address the variations between regions and countries in relation to their income, we aim to compare the management approaches and clinical outcomes of trauma patients resuscitated with REBOA according to the countries'' income based on the World Bank Country and Lending Groups. abstract: BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) could provide a survival benefit to severely injured patients as it may improve their initial ability to survive the hemorrhagic shock. Although the evidence supporting the use of REBOA is not conclusive, its use has expanded worldwide. We aim to compare the management approaches and clinical outcomes of trauma patients treated with REBOA according to the countries’ income based on the World Bank Country and Lending Groups. METHODS: We used data from the AORTA (USA) and the ABOTrauma (multinational) registries. Patients were stratified into two groups: (1) high-income countries (HICs) and (2) low-to-middle income countries (LMICs). Propensity score matching extracted 1:1 matched pairs of subjects who were from an LMIC or a HIC based on age, gender, the presence of pupillary response on admission, impeding hypotension (SBP ≤ 80), trauma mechanism, ISS, the necessity of CPR on arrival, the location of REBOA insertion (emergency room or operating room) and the amount of PRBCs transfused in the first 24 h. Logistic regression (LR) was used to examine the association of LMICs and mortality. RESULTS: A total of 817 trauma patients from 14 countries were included. Blind percutaneous approach and surgical cutdown were the preferred means of femoral cannulation in HICs and LIMCs, respectively. Patients from LMICs had a significantly higher occurrence of MODS and respiratory failure. LR showed no differences in mortality for LMICs when compared to HICs; neither in the non-matched cohort (OR = 0.63; 95% CI: 0.36‑1.09; p = 0.1) nor in the matched cohort (OR = 1.45; 95% CI: 0.63‑3,33; p = 0.3). CONCLUSION: There is considerable variation in the management practices of REBOA and the outcomes associated with this intervention between HICs and LMICs. Although we found significant differences in multiorgan and respiratory failure rates, there were no differences in the risk-adjusted odds of mortality between the groups analyzed. Trauma surgeons practicing REBOA around the world should joint efforts to standardize the practice of this endovascular technology worldwide. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549081/ doi: 10.1186/s13017-020-00337-w id: cord-319218-mejvlkfg author: Marandino, Laura title: The Shifting Landscape of Genitourinary Oncology During the COVID-19 Pandemic and how Italian Oncologists Reacted: Results from a National Survey date: 2020-04-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.eururo.2020.04.004 doi: 10.1016/j.eururo.2020.04.004 id: cord-261736-jlwctmxw author: Marchand, Geneviève title: Bacteria emitted in ambient air during bronchoscopy—a risk to health care workers? date: 2016-12-01 words: 3523.0 sentences: 209.0 pages: flesch: 48.0 cache: ./cache/cord-261736-jlwctmxw.txt txt: ./txt/cord-261736-jlwctmxw.txt summary: The aim of this study was to qualify and quantify bioaerosol concentrations during bronchoscopy to evaluate the occupational risk to HCWs. Knowing the real exposure is essential to encouraging HCWs to implement better prevention protocols and wear personal protective equipment if needed. The average concentrations (colony forming units/meters 3 of air) and the standard deviations of the culturable bacteria measured in the 2 bronchoscopy rooms are presented in Table 1 . To our knowledge, this is the first study to measure and identify the actual bacterial flora present in the ambient air of a room while bronchoscopies are being performed on patients. The identification of Streptococcus pneumoniae, Neisseria sp, and Corynebacterium sp shows that culturable bacteria from oral, nasal, and pulmonary flora were present in the air of the rooms during bronchoscopy procedures. It provides clear evidence of the presence of culturable opportunistic bacteria originating from the respiratory tract of patients in the air of bronchoscopy rooms. abstract: BACKGROUND: Health care workers are at risk of occupational infections, and some procedures are known to increase this risk. The aim of this study was to qualify and quantify bioaerosol concentrations during bronchoscopy to estimate the occupational risk. METHODS: Full-day sampling was conducted in 2 rooms while bronchoscopies were performed on patients. Two microbial air samplers were used, a wet wall cyclonic sampler and an impactor, on culture media. Identification of the culturable bacterial flora was performed with chromatographic analysis of cellular fatty acid of the isolated strain and additional biochemical tests if needed. Specific polymerase chain reaction analysis was completed on wet wall cyclonic samples for the detection of influenza A and B and Mycobacterium spp. RESULTS: A wide variety of bacteria were collected from the ambient air. All samples yielded at least 1 Staphylococcus species. Although most of the culturable bacteria identified were normal nonpathogenic flora, such as Streptococcus spp, Neisseria spp, and Corynebacterium spp, some opportunistic pathogens, such as Streptococcus pneumoniae, were found. Neither Mycobacterium spp nor influenza virus was detected with the polymerase chain reaction method during this study. CONCLUSIONS: Culturable bacteria from oral, nasal, and pulmonary flora are aerosolized during bronchoscopy and could be inhaled by medical staff. The potential presence of pathogens in those aerosols could represent an occupational infection risk. url: https://doi.org/10.1016/j.ajic.2016.04.241 doi: 10.1016/j.ajic.2016.04.241 id: cord-304474-hfv43e9m author: Marchese, Valentina title: Strongyloides infection manifested during immunosuppressive therapy for SARS-CoV-2 pneumonia date: 2020-09-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: SARS-CoV-2 pandemic has posed formidable public health and clinical challenges. The use of immunosuppressive agents, such as high dose corticosteroids and cytokine inhibitors (e.g., Tocilizumab) has been suggested to contrast the hyperinflammatory process involved in the pathogenesis of the severe disease, with conflicting evidence. Among the drawbacks of immunosuppressive therapy, the risk of reactivation of latent infections, including parasitic infestations, is to be considered. CASE PRESENTATION: We report a case of a 59-year-old Italian patient treated with high dose intravenous dexamethasone and two intravenous doses of Tocilizumab for interstitial bilateral pneumonia associated with SARS-CoV-2 infection who developed itching, abdominal pain, and an increased eosinophil count. Stool examination confirmed the presence of S. stercoralis larvae. The patient was treated with a 4-day course of Ivermectin with full recovery. DISCUSSION: We report the first case of S. stercoralis infection following an 11-day treatment with high-dose steroids and Tocilizumab for severe COVID-19. Clinicians should be aware of the risk of strongyloidiasis as a complication of the treatment for severe COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32910321/ doi: 10.1007/s15010-020-01522-4 id: cord-244388-dxrrpxl7 author: Marchiori, Chiara title: Artificial Intelligence Decision Support for Medical Triage date: 2020-11-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Applying state-of-the-art machine learning and natural language processing on approximately one million of teleconsultation records, we developed a triage system, now certified and in use at the largest European telemedicine provider. The system evaluates care alternatives through interactions with patients via a mobile application. Reasoning on an initial set of provided symptoms, the triage application generates AI-powered, personalized questions to better characterize the problem and recommends the most appropriate point of care and time frame for a consultation. The underlying technology was developed to meet the needs for performance, transparency, user acceptance and ease of use, central aspects to the adoption of AI-based decision support systems. Providing such remote guidance at the beginning of the chain of care has significant potential for improving cost efficiency, patient experience and outcomes. Being remote, always available and highly scalable, this service is fundamental in high demand situations, such as the current COVID-19 outbreak. url: https://arxiv.org/pdf/2011.04548v1.pdf doi: nan id: cord-322322-woz6lwdu author: Marcum, Michelle title: COVID‐19 pandemic and impact on cancer clinical trials: An academic medical center perspective date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID‐19 pandemic changed health‐care operations around the world and has interrupted standard clinical practices as well as created clinical research challenges for cancer patients. Cancer patients are uniquely susceptible to COVID‐19 infection and have some of the worst outcomes. Importantly, cancer therapeutics could potentially render cancer patients more susceptible to demise from COVID‐19 yet the poor survival outcome of many cancer diagnoses outweighs this risk. In addition, the pandemic has resulted in risks to health‐care workers and research staff driving important change in clinical research operations and procedures. Remote telephone and video visits, remote monitoring, electronic capture of signatures and data, and limiting sample collections have allowed the leadership in our institution to ensure the safety of our staff and patients while continuing critical clinical research operations. Here we discuss some of these unique challenges and our response to change that was necessary to continue cancer clinical research; and, the impacts the pandemic has caused including increases in efficiency for our cancer research office. url: https://www.ncbi.nlm.nih.gov/pubmed/32648667/ doi: 10.1002/cam4.3292 id: cord-001421-6t5puo6p author: Marfà, Santiago title: Lack of a 5.9 kDa Peptide C-Terminal Fragment of Fibrinogen α Chain Precedes Fibrosis Progression in Patients with Liver Disease date: 2014-10-02 words: 5057.0 sentences: 229.0 pages: flesch: 46.0 cache: ./cache/cord-001421-6t5puo6p.txt txt: ./txt/cord-001421-6t5puo6p.txt summary: The serum proteomic profile and routine liver and renal function tests were initially analyzed in a training set of 10 HCV-RNA recurrent LT patients 6 months post LT that showed a fibrosis stage F$1 at 1 year after LT. HVPG was assessed in 53 of these patients and the average value was of 5.560.8 mm Hg. All the serum samples showed a quite similar expression pattern and coincidences included both the different peptide fragments detected and the signal intensity of these fragments (Data S4). All serum samples included in the test set showed an intensity m/z 5905 peak well below the values found in both healthy subjects and non recurrent HCV patients. In conclusion, we identified a 5.9 kDa C-terminal fragment of the fibrinogen a chain as a serum biomarker of early fibrogenic processes in patients with liver disease. In conclusion, we identified a 5.9 kDa C-terminal fragment of the fibrinogen a chain as a serum biomarker of early fibrogenic processes in patients with liver disease. abstract: Early detection of fibrosis progression is of major relevance for the diagnosis and management of patients with liver disease. This study was designed to find non-invasive biomarkers for fibrosis in a clinical context where this process occurs rapidly, HCV-positive patients who underwent liver transplantation (LT). We analyzed 93 LT patients with HCV recurrence, 41 non-LT patients with liver disease showing a fibrosis stage F≥1 and 9 patients without HCV recurrence who received antiviral treatment before LT, as control group. Blood obtained from 16 healthy subjects was also analyzed. Serum samples were fractionated by ion exchange chromatography and their proteomic profile was analyzed by SELDI-TOF-MS. Characterization of the peptide of interest was performed by ion chromatography and electrophoresis, followed by tandem mass spectrometry identification. Marked differences were observed between the serum proteome profile of LT patients with early fibrosis recurrence and non-recurrent LT patients. A robust peak intensity located at 5905 m/z was the distinguishing feature of non-recurrent LT patients. However, the same peak was barely detected in recurrent LT patients. Similar results were found when comparing samples of healthy subjects with those of non-LT fibrotic patients, indicating that our findings were not related to either LT or HCV infection. Using tandem mass-spectrometry, we identified the protein peak as a C-terminal fragment of the fibrinogen α chain. Cell culture experiments demonstrated that TGF-β reduces α-fibrinogen mRNA expression and 5905 m/z peak intensity in HepG2 cells, suggesting that TGF-β activity regulates the circulating levels of this protein fragment. In conclusion, we identified a 5.9 kDa C-terminal fragment of the fibrinogen α chain as an early serum biomarker of fibrogenic processes in patients with liver disease. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183580/ doi: 10.1371/journal.pone.0109254 id: cord-315696-43wmazxa author: Marinaki, Smaragdi title: A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 (COVID-19) pandemic has posed a significant challenge to physicians and healthcare systems worldwide. Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until 7 July 2020, reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of patients was 55 ± 15 years. There was a male predominance (67%). The majority (74%) were deceased donor recipients, and 23% were recently transplanted (<1 year). Most patients (88%) had at least one comorbidity, 29% had two, and 18% three. Ninety-three percent of cases were hospitalized. Among them, 30% were admitted to the intensive care unit, 45% developed acute respiratory distress syndrome, and 44% had acute kidney injury with 23% needing renal replacement therapy. From the hospitalized patients a total of 22% died, 59% were discharged, and 19% were still in hospital at the time of publication. Immunosuppression was reduced in 27%, discontinued in 31%, and remained unchanged in 5%. Hydroxychloroquine was administered to 78% of patients, antibiotics to 73%, and antivirals to 30% while 25% received corticosteroid boluses, 28% received anti-interleukin agents, and 8% were given immunoglobulin. The main finding of our analysis was that the incidence of COVID-19 among kidney transplant patients is not particularly high, but when they do get infected, this is related to significant morbidity and mortality. url: https://www.ncbi.nlm.nih.gov/pubmed/32947798/ doi: 10.3390/jcm9092986 id: cord-258293-7q9zj8c2 author: Marini, Alessandra title: Letter to the Editor Regarding ''Coronavirus Disease 2019 (COVID-19) and Neurosurgery: Literature and Neurosurgical Societies Recommendations Update'' date: 2020-05-26 words: 921.0 sentences: 52.0 pages: flesch: 46.0 cache: ./cache/cord-258293-7q9zj8c2.txt txt: ./txt/cord-258293-7q9zj8c2.txt summary: with intracranial or spinal oncological pathology (rapidly evolving intracranial hypertension with deteriorating 4 state of consciousness, acute hydrocephalus, spinal cord compression with rapid tetra or paraparesis); Class A + 5 are the patients who requirie treatment within a maximum of 7-10 days, with intracranial tumors with mass 6 effect or with progressive neurological deficit, without deterioration of consciousness and patients requiring 7 treatment within a month, namely Class A, with neurological alteration or suspected malignant lesion, related 8 This resulted in progression of the neurological 4 symptoms, without an early neurosurgical evaluation, until the onset of acute deficit which actually led to the 5 emergency room access. symptoms were consciousness alteration and seizures; in our survey approximately 10,7 % of the acute-onset 0 patients reported to have previously refused the surgical treatment, in the weeks before, correlated to concerns 1 about the hospitalization during the Coronavirus emergency. In conclusion, during the COVID-19 pandemic the neurosurgical urgent and emergency onset of neuro-6 oncological cases increased, in comparison to 2019. Illustrative Table regarding the epidemiological variations in neuro-oncological patients'' onset during the COVID-19 crisis abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1878875020311311?v=s5 doi: 10.1016/j.wneu.2020.05.160 id: cord-320663-xypg6evo author: Market, Marisa title: Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Natural Killer (NK) cells are innate immune responders critical for viral clearance and immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in fighting SARS-CoV-2 has not yet been directly investigated. Insights into pathophysiology and therapeutic opportunities can therefore be inferred from studies assessing NK cell phenotype and function during SARS, MERS, and COVID-19. These studies suggest a reduction in circulating NK cell numbers and/or an exhausted phenotype following infection and hint toward the dampening of NK cell responses by coronaviruses. Reduced circulating NK cell levels and exhaustion may be directly responsible for the progression and severity of COVID-19. Conversely, in light of data linking inflammation with coronavirus disease severity, it is necessary to examine NK cell potential in mediating immunopathology. A common feature of coronavirus infections is that significant morbidity and mortality is associated with lung injury and acute respiratory distress syndrome resulting from an exaggerated immune response, of which NK cells are an important component. In this review, we summarize the current understanding of how NK cells respond in both early and late coronavirus infections, and the implication for ongoing COVID-19 clinical trials. Using this immunological lens, we outline recommendations for therapeutic strategies against COVID-19 in clearing the virus while preventing the harm of immunopathological responses. url: https://doi.org/10.3389/fimmu.2020.01512 doi: 10.3389/fimmu.2020.01512 id: cord-012665-fflye8a3 author: Marques-Vidal, Pedro title: Statistical issues regarding the article by Liu et al. date: 2020-09-02 words: 241.0 sentences: 29.0 pages: flesch: 82.0 cache: ./cache/cord-012665-fflye8a3.txt txt: ./txt/cord-012665-fflye8a3.txt summary: key: cord-012665-fflye8a3 title: Statistical issues regarding the article by Liu et al. cord_uid: fflye8a3 I read with interest the article by Liu et al. [1] on the effect of malnutrition status among elderly patients with COVID-19. I have some questions regarding the analysis of the data. • For each patient, four nutritional risk scores were computed. Comparing the prevalence of "at risk" patients between scores cannot be performed by simple chi-square, as the data come from the same sample (i.e., the data is not independent). It seems that the authors computed the OR for the non-at risk patients. Recomputing the OR leads to a value of 9.80, which is more compatible with the effects of malnutrition on increased LOS. • I am surprised that p values of zero are presented. Clinical significance of nutritional risk screening for older adult patients with COVID-19 abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467396/ doi: 10.1038/s41430-020-00730-3 id: cord-273913-xem3alih author: Marraha, Farah title: A Review of the Dermatological Manifestations of Coronavirus Disease 2019 (COVID-19) date: 2020-08-11 words: 4225.0 sentences: 234.0 pages: flesch: 48.0 cache: ./cache/cord-273913-xem3alih.txt txt: ./txt/cord-273913-xem3alih.txt summary: In this review, we discuss these various cutaneous manifestations and skin problems related to personal protective equipment, as well as different cutaneous anti-COVID-19 drug-associated reactions. e first case infected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was reported in Wuhan, China, in late November 2019. ese skin lesions can guide clinicians for diagnosis if the patients present other COVID-19 symptoms; however, viral infection cannot be the only cause; mediated inflammatory responses and drug reactions can also be suspected. e aim of our literature review is to report the various cutaneous manifestations described to date associated with COVID-19, the skin problems related to personal protective equipment, and the different cutaneous anti-COVID-19 drug reactions [6, 7] . e frequency of the skin lesions associated with COVID-19 infection varies according to the series; in a Chinese study of 1099 positive cases, the incidence was only 0.2%, while in an Italian series of 88 patients it was 20.4% [42] . abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected 210 countries and territories around the world. The virus has spread rapidly, and the disease is still extending up to now. The pathophysiology for SARS-CoV-2 has not been well elucidated, and diverse hypotheses to date have been proposed. Initially, no skin manifestations were observed among patients with COVID-19, but recently a few cases have been described. In this review, we discuss these various cutaneous manifestations and skin problems related to personal protective equipment, as well as different cutaneous anti-COVID-19 drug-associated reactions. We also focus on the currently proposed managements of these rare manifestations. url: https://doi.org/10.1155/2020/9360476 doi: 10.1155/2020/9360476 id: cord-273091-40gda9n9 author: Marrie, Thomas J. title: Empiric treatment of ambulatory community-acquired pneumonia: always include treatment for atypical agents date: 2005-03-01 words: 4364.0 sentences: 244.0 pages: flesch: 45.0 cache: ./cache/cord-273091-40gda9n9.txt txt: ./txt/cord-273091-40gda9n9.txt summary: reviews studies that attempt to answer whether it is necessary to include antibiotics that are active against ''''atypical'''' pneumonia agents as part of the empiric therapy of CAP. Sobradillo and colleagues [55] performed a prospective randomized, double-blind study of doxycycline (Doryx) and erythromycin in the treatment of 48 patients who had Q fever pneumonia. Pneumonia requiring hospitalization: data from large retrospective studies and from observational studies Oosterheert and colleagues [68] performed a systematic review to determine the evidence for the current recommendations for the empiric antimicrobial therapy of patients hospitalized with CAP. There are no data from proper studies to answer whether it is necessary to include antibiotics that are active against atypical pneumonia agents as part of the empiric therapy of CAP. There are no data from proper studies to answer whether it is necessary to include antibiotics that are active against atypical pneumonia agents as part of the empiric therapy of CAP. abstract: There are no data from proper studies to answer whether it is necessary to include antibiotics that are active against atypical pneumonia agents as part of the empiric therapy of CAP. Until such data are available, clinical judgment and severity of the pneumonic illness are the best guides to empiric antimicrobial therapy. url: https://api.elsevier.com/content/article/pii/S0891552004000947 doi: 10.1016/j.idc.2004.07.002 id: cord-335892-hwahcec5 author: Marshall, Elena title: Prevalence of hydroxychloroquine retinopathy using 2018 Royal College of Ophthalmologists diagnostic criteria date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: To measure the prevalence of hydroxychloroquine retinopathy in patients attending a hydroxychloroquine monitoring service using 2018 Royal College of Ophthalmologists diagnostic criteria. METHODS: A service evaluation audit of a hydroxychloroquine retinopathy monitoring service was undertaken. Results of Humphrey 10–2 field tests, spectral-domain optical coherence tomography and fundus autofluorescence were collected with data on dose, weight, duration of treatment, estimated glomerular filtration rate, and concurrent tamoxifen therapy. Visual field tests were assessed as reliable or unreliable, and classified as normal, hydroxychloroquine-like, poor test or related to other pathology. Cases of definite and possible retinopathy were identified using the 2018 RCOphth criteria. RESULTS: There were 1976 attendances over two years of 1597 patients. Seven hundred and twenty-eight patients had taken hydroxychloroquine for less than 5 years and 869 had taken hydroxychloroquine for 5 years or more. Fourteen patients were identified with definite hydroxychloroquine retinopathy (1.6%), and 41 patients with possible retinopathy (4.7%). Sixty-seven per cent of 861 visual fields were performed reliably, with 66.9% classified as normal, 24.9% as poor test, 5.2% hydroxychloroquine-like and 3.0% abnormal due to other pathology. CONCLUSIONS: The 1.6% prevalence of hydroxychloroquine retinopathy is lower than the previously reported prevalence of 7.5% as reported by Melles and Marmor JAMA Ophthalmol 132: 1453–60 (2014). This is because of a difference in the diagnostic criteria. Both definite and possible retinopathy would meet the diagnostic criteria of the Melles and Marmor study; 6.3% in our data, compared with 7.5%, a much smaller difference and likely to be explained by differences in the risk characteristics of the two groups. url: https://doi.org/10.1038/s41433-020-1038-2 doi: 10.1038/s41433-020-1038-2 id: cord-023483-owgs4syo author: Marshall, John L title: Colorectal cancer care in the age of coronavirus: strategies to reduce risk and maintain benefit date: 2020-04-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170009/ doi: 10.2217/crc-2020-0010 id: cord-279719-z0wuajpx author: Martin-Fumadó, Carles title: Medico-legal and ethical considerations on resource limitation and clinical decisions during the COVID-19 pandemic date: 2020-07-15 words: 4957.0 sentences: 263.0 pages: flesch: 46.0 cache: ./cache/cord-279719-z0wuajpx.txt txt: ./txt/cord-279719-z0wuajpx.txt summary: Resource rationing has been necessary in the COVID-19 pandemic, and therefore consensus documents have been published for decision-making based on four fundamental ethical values: maximization of benefits, treating people equally, contributing to creating social value and giving priority to the worst off, from which specific recommendations derive: maximize benefits; prioritize health workers; do not prioritize attendance on a first-COme, first-served basis; be sensitive to scientific evidence; recognize participation in research and apply the same principles to COVID-19 patients as to non-COVID-19 patients. The aspects associated with the principle of justice expressed by Beauchamp and Childress will therefore be of key importance in resolving the ethical and medical-legal problems arising from the fair assignation of resources during the COVID-19 pandemic. abstract: Abstract The COVID-19 pandemic has raised ethical and medico-legal problems, which include the equitable allocation of health resources, especially in relation to the prioritization of patients and the rationing of resources. Priority setting is always present in healthcare systems and depends on the theory of justice applicable in each society. Resource rationing has been necessary in the COVID-19 pandemic, and therefore consensus documents have been published for decision-making based on four fundamental ethical values: maximization of benefits, treating people equally, contributing to creating social value and giving priority to the worst off, from which specific recommendations derive: maximize benefits; prioritize health workers; do not prioritize attendance on a first-COme, first-served basis; be sensitive to scientific evidence; recognize participation in research and apply the same principles to COVID-19 patients as to non-COVID-19 patients. url: https://api.elsevier.com/content/article/pii/S2445424920300224 doi: 10.1016/j.remle.2020.05.004 id: cord-335977-f00758o2 author: Martin-Loeches, I. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial. METHODS: Prospective, observational, multicenter study from 23 June 2009 through 11 February 2010, reported in the European Society of Intensive Care Medicine (ESICM) H1N1 registry. RESULTS: Two hundred twenty patients admitted to an intensive care unit (ICU) with completed outcome data were analyzed. Invasive mechanical ventilation was used in 155 (70.5%). Sixty-seven (30.5%) of the patients died in ICU and 75 (34.1%) whilst in hospital. One hundred twenty-six (57.3%) patients received corticosteroid therapy on admission to ICU. Patients who received corticosteroids were significantly older and were more likely to have coexisting asthma, chronic obstructive pulmonary disease (COPD), and chronic steroid use. These patients receiving corticosteroids had increased likelihood of developing hospital-acquired pneumonia (HAP) [26.2% versus 13.8%, p < 0.05; odds ratio (OR) 2.2, confidence interval (CI) 1.1–4.5]. Patients who received corticosteroids had significantly higher ICU mortality than patients who did not (46.0% versus 18.1%, p < 0.01; OR 3.8, CI 2.1–7.2). Cox regression analysis adjusted for severity and potential confounding factors identified that early use of corticosteroids was not significantly associated with mortality [hazard ratio (HR) 1.3, 95% CI 0.7–2.4, p = 0.4] but was still associated with an increased rate of HAP (OR 2.2, 95% CI 1.0–4.8, p < 0.05). When only patients developing acute respiratory distress syndrome (ARDS) were analyzed, similar results were observed. CONCLUSIONS: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection did not result in better outcomes and was associated with increased risk of superinfections. url: https://www.ncbi.nlm.nih.gov/pubmed/21107529/ doi: 10.1007/s00134-010-2078-z id: cord-011327-zsoc4wec author: Martin-Loeches, Ignacio title: Antibiotic prophylaxis in the ICU: to be or not to be administered for patients undergoing procedures? date: 2019-11-28 words: 1973.0 sentences: 95.0 pages: flesch: 27.0 cache: ./cache/cord-011327-zsoc4wec.txt txt: ./txt/cord-011327-zsoc4wec.txt summary: However, SAP is also commonly practiced in many ICUs. A single-centre study conducted recently in a Belgian ICU showed that SAP and prophylaxis for immunocompromised patients constituted two-thirds of prophylactic antibiotic treatments prescribed [13] . There are no randomised controlled trials on the effects of timing or choice of antibiotic prophylaxis on the outcomes of ICU patients requiring unplanned surgical procedures. However, French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU suggest consideration of selective digestive decontamination with both topical and systemic antibiotics (for a maximum of 96 h) to decrease the rate of pneumonia immediately after urgent intubation based on indirect evidence from several studies [22] . A metaanalysis of studies focused on antibiotic prophylaxis for chest drain insertion in non-ICU patients (i.e. thoracic injury), concluded that treatment after chest drain insertion was significantly associated with a reduced risk of empyema (RR 0.25; 95% CI 0.13-0.49) and pneumonia (RR 0.41; 95% CI 0.24-0.71) when compared with placebo alone [28] . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224040/ doi: 10.1007/s00134-019-05870-0 id: cord-291168-4u4cssky author: Martin-Villares, Cristina title: Outcome of 1890 tracheostomies for critical COVID-19 patients: a national cohort study in Spain date: 2020-08-04 words: 3217.0 sentences: 215.0 pages: flesch: 55.0 cache: ./cache/cord-291168-4u4cssky.txt txt: ./txt/cord-291168-4u4cssky.txt summary: METHODS: A multicentric prospective observational study of 1890 COVID-19 patients undergoing tracheostomy across 120 hospitals was conducted over 7 weeks in Spain (March 28 to May 15, 2020). The group has performed a national multicentric prospective observational study on 1890 COVID-19 critical patients undergoing tracheostomy in a total of 120 hospitals in Spain. On early March, 2020, at a very critical moment of the pandemic in Spain and without published data yet from initial experiences in China or Italy, Spanish otolaryngologists began their first tracheostomies in Madrid (March, 11) and Barcelona (March, 16) , with the onrush of more than a thousand patients in their respective overcrowded ICUs, which doubled its current capacity. Between March 28 and May 15, the Spanish COVID Group, encompassing 120 hospitals, performed 1890 tracheostomies, the equivalent of 16.4% of all registered ICU patients with mechanical ventilation in Spain. abstract: BACKGROUND: The question of an optimal strategy and outcomes in COVID-19 tracheostomy has not been answered yet. The critical focus in our case study is to evaluate the outcomes of tracheostomy on intubated COVID-19 patients. METHODS: A multicentric prospective observational study of 1890 COVID-19 patients undergoing tracheostomy across 120 hospitals was conducted over 7 weeks in Spain (March 28 to May 15, 2020). Data were collected with an innovative approach: instant messaging via WhatsApp. Outcome measurements: complications, achieved weaning and decannulation and survival. RESULTS: We performed 1,461 surgical (81.3%) and 429 percutaneous tracheostomies. Median timing of tracheostomy was 12 days (4–42 days) since orotracheal intubation. A close follow-up of 1616/1890 (85.5%) patients at the cut-off time of 1-month follow-up showed that in 842 (52.1%) patients, weaning was achieved, while 391 (24.2%) were still under mechanical ventilation and 383 (23.7%) patients had died from COVID-19. Decannulation among those in whom weaning was successful (n = 842) was achieved in 683 (81%) patients. CONCLUSION: To the best of our knowledge, this is the largest cohort of COVID-19 patients undergoing tracheostomy. The critical focus is the unprecedented amount of tracheostomies: 1890 in 7 weeks. Weaning could be achieved in over half of the patients with follow-up. Almost one out of four tracheotomized patients died from COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32749607/ doi: 10.1007/s00405-020-06220-3 id: cord-287732-abzpfdcu author: Martindale, Robert title: Nutrition Therapy in Critically Ill Patients with Coronavirus Disease (COVID‐19) date: 2020-05-27 words: 6232.0 sentences: 371.0 pages: flesch: 42.0 cache: ./cache/cord-287732-abzpfdcu.txt txt: ./txt/cord-287732-abzpfdcu.txt summary: These variables have implications for nutritional interventions: [1] older patients are at-risk for pre-existing disease and sarcopenia which increases their risk for pre-existing malnutrition and increased risk of refeeding syndrome, [2] severe acute respiratory distress syndrome (ARDS) with refractory hypoxemia may require prone-positioning and/or extracorporeal membrane oxygenation (ECMO), [3] circulatory failure and concomitant feeding may increase the risk of gut ischemia and feeding intolerance, [4] multiple organ failure (MOF) and the need for early enteral nutrition (EN) to attenuate or mitigate gut derived inflammation, and [5] cytokine release syndrome which alters nutrient utilization (especially lipids). Recommendation 1: We recommend all healthcare providers, including dietitians, nurses, and physicians follow PPE standards set forth by the CDC and/or the WHO and adhere to their institutional guidelines when conducting bedside nutritional assessments for all patients with confirmed or suspected COVID-19 disease. abstract: In the midst of a worldwide pandemic of the Coronavirus Disease 2019 (COVID‐19), a paucity of data precludes derivation of COVID‐19‐specific recommendations for nutritional therapy. Until more data are available, the focus needs to center on principles of critical care nutrition modified for the constraints of this disease process, i.e., COVID‐19‐relevant recommendations. Delivery of nutritional therapy must include strategies to reduce exposure and spread of the disease by providing clustered care, adequate protection of healthcare providers, and preservation of personal protective equipment. Enteral nutrition (EN) should be initiated early after admission to the intensive care unit (ICU) using a standard isosmolar polymeric formula, starting at trophic doses and advancing as tolerated while monitoring for gastrointestinal intolerance, hemodynamic instability, and metabolic derangements. Intragastric EN may be provided safely, even with use of prone positioning and extracorporeal membrane oxygenation. Clinicians, though, should have a lower threshold for switching to parenteral nutrition in cases of intolerance, high risk of aspiration, or escalating vasopressor support. While data extrapolated from experience in Acute Respiratory Distress Syndrome (ARDS) warrants use of fiber additives and probiotic organisms. The lack of demonstrated benefit precludes a recommendation for micronutrient supplementation. Practices which increase exposure or contamination of equipment, such as use of gastric residual volumes as a monitor, indirect calorimetry to calculate requirements, endoscopy or fluoroscopy to achieve enteral access, or transport out of the ICU for additional imaging should be avoided. At all times, strategies for nutritional therapy need to be assessed on a risk/benefit basis, paying attention to risk for both the patient and the healthcare provider. This article is protected by copyright. All rights reserved url: https://www.ncbi.nlm.nih.gov/pubmed/32462719/ doi: 10.1002/jpen.1930 id: cord-006343-c0amee70 author: Martinez Rivera, Andrea title: Intestinal transplantation in children: current status date: 2016-03-31 words: 4976.0 sentences: 247.0 pages: flesch: 40.0 cache: ./cache/cord-006343-c0amee70.txt txt: ./txt/cord-006343-c0amee70.txt summary: Intestinal transplantation (IT) is the least common form of organ transplantation; however, it has shown exceptional growth and improvement in graft survival rates over the past two decades mainly due to better outcomes achieved during the first year of transplantation (76 % at 1 year), due to improvement in surgical techniques and the development of better immunosupressive therapies as we understand more about the relationship between the recipient and host immune system. It remains on the continuum of care for pediatric patients with intestinal failure, but bowel transplant rates have declined worldwide over the last 6 years, in large part due to the development of multidisciplinary intestinal rehabilitation programs and the control of progressive cholestatic liver disease with novel lipid-based management strategies. With improved clinical outcomes of pediatric patients with intestinal failure, there is increasing evidence that the current indications for bowel transplantation no longer apply and need revision. abstract: Intestinal transplantation (IT) is the least common form of organ transplantation; however, it has shown exceptional growth and improvement in graft survival rates over the past two decades mainly due to better outcomes achieved during the first year of transplantation (76 % at 1 year), due to improvement in surgical techniques and the development of better immunosupressive therapies as we understand more about the relationship between the recipient and host immune system. There are still ongoing issues with chronic rejection and long-term survival. Intestinal transplantation is still an acceptable therapy for patients with intestinal failure (IF), but it is generally reserved for patients who develop severe and life-threatening complications despite standard therapies, or those who are not able to maintain a good quality of life. The purpose of this review is to describe the current status, indications, outcomes and advances in the field of intestinal transplantation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101640/ doi: 10.1007/s00383-016-3885-2 id: cord-289806-6ihptx6n author: Martinez, Rebecca title: Critical Obstetric Patients During the Coronavirus Disease 2019 Pandemic: Operationalizing an Obstetric Intensive Care Unit date: 2020-10-07 words: 3186.0 sentences: 155.0 pages: flesch: 39.0 cache: ./cache/cord-289806-6ihptx6n.txt txt: ./txt/cord-289806-6ihptx6n.txt summary: The pandemic brought near-complete cessation of nonurgent hospital activities with the rapid expansion of critical care services, with the notable exception of the labor and delivery unit (LDU), which continued to have a full complement of patients presenting for obstetric care. By the time the obstetric ICU (OBICU) was fully operational (end of March), the volume demand was mildly curtailed by some patients electing to leave NYC; however, interinstitutional transfers for maternal or fetal indications provided steady demands for care, with fluctuations occurring week by week. However, a key difference is that the critical care attendings (ICU oversight) are not ultimately responsible for patient care decisions and provide ad hoc consultations if deemed needed by the obstetric anesthesia attending. Daily online lectures by the Internal Medicine or Anesthesia departments review critical care topics that are both general in nature and specific to SARS-CoV-2 infection; these lectures while targeted at residents were available to all members of the OBICU team. abstract: Supplemental Digital Content is available in the text. url: https://www.ncbi.nlm.nih.gov/pubmed/33002930/ doi: 10.1213/ane.0000000000005253 id: cord-290975-2kmvyovm author: Martinotti, Giovanni title: Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy date: 2020-09-03 words: 4250.0 sentences: 195.0 pages: flesch: 41.0 cache: ./cache/cord-290975-2kmvyovm.txt txt: ./txt/cord-290975-2kmvyovm.txt summary: In this paper, we aim at evaluating the impact that the COVID-19 pandemic, and the relative containment measures, have had on a real-life sample of patients suffering from substance use disorders (SUDs) and/or behavioral addictions. Within the general population, problems such as feelings of frustration, aggressive behavior (2) , post-traumatic stress symptoms (PTSS), depression, anxiety, insomnia, perceived stress, and adjustment disorder symptoms (ADS) have increased (3) , with the consequent risk of self-medication through the abuse of alcohol and/or psychoactive substances and with a greater tendency to engage in pathological behaviors (gambling and internet addiction). The aim of this study was to evaluate the impact that the COVID-19 pandemic, and the relative containment measures adopted by the Italian Government, had on patients with SUDs and/or behavioral addictions; to assess the psychopathological burden in terms of depression, anxiety, post-traumatic load; and to evaluate the relevance of craving symptoms and their correlation with psychiatric symptoms and quality of life. abstract: BACKGROUND: Following the development of the COVID-19 pandemic, a rigid public health strategy of reduced social contact and shelter-in-place has been adopted by the Italian Government to reduce the spread of the virus. In this paper, we aim at evaluating the impact that the COVID-19 pandemic, and the relative containment measures, have had on a real-life sample of patients suffering from substance use disorders (SUDs) and/or behavioral addictions. METHODS: An anonymous questionnaire was filled out by 153 addicted patients, both outpatients and residential inpatients, recruited across Italy and highly representative of the current Italian population suffering from addictions. Psychopathological burden (anxiety and depressive symptomatology, somatization, irritability, and post-traumatic symptoms), quality of life, and craving changes in daily habits were assessed. RESULTS: In our sample, we found moderate rates of depression (22.9%), anxiety (30.1%), irritability (31.6%), and post-traumatic stress (5.4%) symptoms. Psychopathological burden was globally higher among residential patients. Reported levels of craving were generally low. DISCUSSION: This study is the first attempt to collect Italian data regarding the effects of the rigid quarantine period, during the COVID-19 pandemic, on patients suffering from a SUD and/or behavioral addictions. The presence of a moderate psychopathological burden correlated to poor quality of life and low craving scores represented the main outcomes. Long-term studies, with follow-up after the end of the restrictive measures, should be considered to implement our findings. url: https://www.ncbi.nlm.nih.gov/pubmed/33101086/ doi: 10.3389/fpsyt.2020.572245 id: cord-015922-5wwy0m2k author: Marty, Francisco M. title: Infection in the Hematopoietic Stem Cell Transplant Recipient date: 2008 words: 10254.0 sentences: 489.0 pages: flesch: 33.0 cache: ./cache/cord-015922-5wwy0m2k.txt txt: ./txt/cord-015922-5wwy0m2k.txt summary: Other prophylactic strategies commonly utilized in HSCT patients include acyclovir to prevent herpes simplex virus (HSV) and VZV reactivation, fluoroquinolones [5] to prevent gram-negative sepsis and fluconazole to prevent yeast infection. It has been suggested that EBV viral load surveillance in peripheral blood be carried out in high risk patients (those with primary EBV infection, anti-T cell antibody therapy for GVHD, HLA-mismatched or T cell-depleted HSCT recipients), with decreased immunosuppression +/− antiviral therapy (acyclovir or ganciclovir) carried out in the setting of high viral loads [1, 4, 41, 42] . Infliximab use in patients with severe graftversus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120030/ doi: 10.1007/978-1-59745-438-4_19 id: cord-299570-1xz5r95f author: Martínez-García, M title: Telemedicina con telemonitorización en el seguimiento de pacientes con COVID-19 date: 2020-06-05 words: 1611.0 sentences: 159.0 pages: flesch: 58.0 cache: ./cache/cord-299570-1xz5r95f.txt txt: ./txt/cord-299570-1xz5r95f.txt summary: Métodos: Estudio observacional prospectivo de los pacientes con diagnóstico de COVID-19 por PCR positiva y considerados de alto riesgo que se siguieron con telemedicina y telemonitorización en el Área Sanitaria de Lugo entre el 17 de marzo y el 17 de abril de 2020. Conclusiones: Nuestros datos sugieren que la telemedicina con telemonitorización domiciliaria, utilizada de forma proactiva, permite un seguimiento clínicamente útil y seguro en pacientes con COVID-19 de alto riesgo. Our study suggests that telemedicine with home telemonitoring, used proactively, allows for monitoring high-risk patients with COVID-19 in a clinically useful and secure way. Our study suggests that telemedicine with home telemonitoring, used proactively, allows for monitoring high-risk patients with COVID-19 in a clinically useful and secure way. Los datos de este estudio sugieren que el seguimiento domiciliario con telemedicina y telemonitorización en pacientes COVID-19 es un sistema bien aceptado, útil y seguro. abstract: ABSTRACT Aim. To asses if telemedicine with telemonitoring is a clinically useful and secure tool in the tracking of patients with COVID-19. Methods. A prospective observational study of patients with COVID-19 diagnosis by positive PCR considered high-risk tracked with telemedicine and telemonitoring was conducted in the sanitary area of Lugo between March 17th and April 17th, 2020. Two groups of patients were included: Outpatient Tracing from the beginning and after discharge. Every patient sent a daily clinical questionnaire with temperature and oxygen saturation 3 times a day. Proactive monitoring was done by getting in touch with every patient at least once a day. Results. 313 patients (52.4% female) with a total average age of 60.9 (DS 15.9) years were included. Additionally, 2 patients refused to join the program. Since the beginning, 224 were traced outpatient and 89 after being discharged. Among the first category, 38 (16.90%) were referred to Emergency department on 43 occasions; 18 were hospitalized (8.03%), and 2 deceased. Neither deaths nor a matter of vital emergency occurred at home. When including patients after admissions monitoring was done in 304 cases. One patient re-entered (0.32%) to the hospital, and another one left the program (0.32%). The average time of monitoring was 11.64 (SD 3.58) days, and 224 (73.68%) patients were discharged during the 30 days of study. Conclusions. Our study suggests that telemedicine with home telemonitoring, used proactively, allows for monitoring high-risk patients with COVID-19 in a clinically useful and secure way. url: https://api.elsevier.com/content/article/pii/S0014256520301557 doi: 10.1016/j.rce.2020.05.013 id: cord-290295-gl144dh9 author: Martínez-López, Joaquín title: Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality date: 2020-10-19 words: 4086.0 sentences: 186.0 pages: flesch: 36.0 cache: ./cache/cord-290295-gl144dh9.txt txt: ./txt/cord-290295-gl144dh9.txt summary: Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. There are cumulative data indicating that patients with cancer may be at increased risk for more severe COVID-19 and associated complications, including those receiving or not receiving treatment within the month prior to infection 5, 6 , although other recent results suggest mortality may be primarily associated with age, male sex, and comorbidities 7 . To our knowledge, this is the first large case-series study to describe comprehensively the clinical characteristics of COVID-19 in hospitalized MM patients, compare outcomes with a noncancer cohort of COVID-19 patients, and identify preadmission prognostic factors of inpatient mortality. abstract: There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admitted at six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients were male; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity was moderate–severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was required by 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasive ventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19. url: https://doi.org/10.1038/s41408-020-00372-5 doi: 10.1038/s41408-020-00372-5 id: cord-342979-pvewvmmf author: Martínez-del Río, Jorge title: Comparative analysis between the use of renin-angiotensin system antagonists and clinical outcomes of hospitalized patients with COVID-19 respiratory infection date: 2020-11-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction Hypertension has been associated with worse outcomes in patients with COVID-19 infection, so concerns have been raised about the possibility that inhibitors of the renin-angiotensin system (RAS) could influence the prognosis of these patients. Methods This is an observational study of 921 consecutive patients admitted with COVID-19 respiratory infection to Hospital General Universitario Ciudad Real from March 1 to April 30, 2020. Following data were collected including patient demographic information, medical history, clinical characteristics, laboratory data, therapeutic interventions during the hospitalization and clinical outcomes. Results The mean age was 78years, and 59.2% of patients had a history of hypertension. Patients with previous treatment with RAS inhibitor (42.4%) showed lower risk of the primary composite endpoint (mortality or need for invasive mechanical ventilation). Treatment with RAS inhibitor (both outpatient treatment and during hospitalization) had neither effect on mortality nor need for invasive ventilation. There were no differences in time-to-event analysis between groups. Conclusions RAS inhibitor treatment prior to admission in patients with COVID-19 respiratory infection was associated with lower risk of the primary composite endpoint and did not show neither impact on mortality nor need for invasive mechanical ventilation, even if these drugs were prescribed during hospitalization. url: https://api.elsevier.com/content/article/pii/S2387020620305283 doi: 10.1016/j.medcle.2020.07.013 id: cord-290051-22gwwrpw author: Masaki, Shigenori title: Endotracheal intubation in patients with COVID-19 using an ultrathin flexible gastrointestinal endoscope date: 2020-10-16 words: 1275.0 sentences: 77.0 pages: flesch: 40.0 cache: ./cache/cord-290051-22gwwrpw.txt txt: ./txt/cord-290051-22gwwrpw.txt summary: Therefore, we simulated fiberoptic endotracheal intubation on a mannequin representing the patient, using an ultrathin flexible gastrointestinal endoscope as an alternative to the bronchoscope, in order to maintain distance from the patient during the procedure. Therefore, we simulated fiberoptic endotracheal intubation on a mannequin representing the patient, using an ultrathin flexible gastrointestinal endoscope as an alternative to the bronchoscope, in order to maintain distance from the patient during the procedure. The flexible tip-steerable control and length of the gastrointestinal endoscope contributed to shortening the procedure time and maintaining distance from the patients. The flexible tip-steerable control and length of the gastrointestinal endoscope contributed to shortening the procedure time and maintaining distance from the patients. Endotracheal intubation using an ultrathin flexible gastrointestinal endoscope is a quick and reliable procedure that can be performed while maintaining distance from the patient. abstract: Pneumonia caused by severe acute respiratory syndrome coronavirus 2 occasionally becomes severe and requires endotracheal intubation. Endotracheal intubation is usually performed using a laryngoscope; however, the operator needs to be in close proximity to the patient’s face during the procedure, which increases the risk of droplet exposure. Therefore, we simulated fiberoptic endotracheal intubation on a mannequin representing the patient, using an ultrathin flexible gastrointestinal endoscope as an alternative to the bronchoscope, in order to maintain distance from the patient during the procedure. We performed this procedure 10 times and measured the time required; the median procedure time was 6.4 s (interquartile range, 5.7-8.1 s). The advantage of this method is the short procedure time and distance maintained from the patients. The flexible tip-steerable control and length of the gastrointestinal endoscope contributed to shortening the procedure time and maintaining distance from the patients. In addition, this method can handle difficult airways without risk of misplacement of the endotracheal tube. However, it is necessary to consider the risk of aerosol generation associated with this procedure. In the pandemic setting of coronavirus disease 2019, this approach may be useful when a gastrointestinal endoscopist is in charge of endotracheal intubation of patients with coronavirus disease 2019. url: https://doi.org/10.4253/wjge.v12.i10.404 doi: 10.4253/wjge.v12.i10.404 id: cord-289179-3zfur0zh author: Mascarin, Maurizio title: How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients date: 2020-04-11 words: 543.0 sentences: 38.0 pages: flesch: 50.0 cache: ./cache/cord-289179-3zfur0zh.txt txt: ./txt/cord-289179-3zfur0zh.txt summary: title: How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients According to Liang 1 , as of Jan 31, 2020, based on a cohort of patients in China, 1% of coronavirus disease (COVID-19) cases had a history of cancer. Starting mid-February 2020, we applied these rules for outpatients undergoing radiotherapy: 1) telephonic triage the day before the first admission, and specific clinical triage the day of admission in a dedicated area; 2) daily detailed medical history to detect the possibility of COVID-19 contagion; 3) postponement of non-essential check-ups; 4) medical evaluation or nasopharyngeal swab for patients with rhinitis, conjunctivitis, cough or fever in order to access the hospital; 5) education on hand-washing, no touching mouth, nose, and eyes; 6) couch and mask disinfection after every radiotherapy fraction; 7) compulsory surgical masks for patients, parents and healthcare workers; 8) no volunteers allowed; 9) nasopharyngeal swabs only for people with symptoms or family risk conditions. In most hospitals worldwide, the radiotherapy department is shared by pediatric, adult and elderly patients. abstract: nan url: https://api.elsevier.com/content/article/pii/S2452109420300713 doi: 10.1016/j.adro.2020.04.002 id: cord-310690-50z2kdaj author: Maschmeyer, Georg title: How to manage lung infiltrates in adults suffering from haematological malignancies outside allogeneic haematopoietic stem cell transplantation date: 2016-01-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Pulmonary complications affect up to 40% of patients with severe neutropenia lasting for more than 10 d. As they are frequently associated with fever and elevation of C‐reactive protein or other signs of inflammation, they are mostly handled as pneumonia. However, the differential diagnosis is broad, and a causative microbial agent remains undetected in the majority of cases. Pulmonary side effects from cytotoxic treatment or pulmonary involvement by the underlying malignancy must always be taken into account and may provide grounds for invasive diagnostic procedures in selected patients. Pneumocystis jirovecii (in patients not receiving co‐trimoxazole as prophylaxis), multi‐resistant gram‐negative bacilli, mycobacteria or respiratory viruses may be involved. High‐risk patients may be infected by filamentous fungi, such as Aspergillus spp., but these infections are seldom proven when treatment is initiated. Microorganisms isolated from cultures of blood, bronchoalveolar lavage or respiratory secretions need careful interpretation as they may be irrelevant for determining the aetiology of pulmonary infiltrates, particularly when cultures yield coagulase‐negative staphylococci, enterococci or Candida species. Non‐culture based diagnostics for detecting Aspergillus galactomannan, beta‐D‐glucan or DNA from blood, bronchoalveolar lavage or tissue samples can facilitate the diagnosis, but must always be interpreted in the context of clinical and imaging findings. Systemic antifungal treatment with mould‐active agents, given in combination with broad‐spectrum antibiotics, improves clinical outcome when given pre‐emptively. Co‐trimoxazole remains the first‐line treatment for Pneumocystis pneumonia, while cytomegalovirus pneumonia will respond to ganciclovir or foscarnet in most cases. The clinical outcome of acute respiratory failure can also be successful with proper intensive care, when indicated. url: https://doi.org/10.1111/bjh.13934 doi: 10.1111/bjh.13934 id: cord-325631-c7jwizpj author: Masetti, Chiara title: High mortality in COVID‐19 patients with mild respiratory disease date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has infected 189 000 people in Italy, with more than 25 000 deaths. Several predictive factors of mortality have been identified; however, none has been validated in patients presenting with mild disease. METHODS: Patients with a diagnosis of interstitial pneumonia caused by SARS‐CoV‐2, presenting with mild symptoms, and requiring hospitalization in a non‐intensive care unit with known discharge status were prospectively collected and retrospectively analysed. Demographical, clinical and biochemical parameters were recorded, as need for non‐invasive mechanical ventilation and admission in intensive care unit. Univariate and multivariate logistic regression analyses were used to identify independent predictors of death. RESULTS: Between 28 February and 10 April 2020, 229 consecutive patients were included in the study cohort; the majority were males with a mean age of 60 years. 54% of patients had at least one comorbidity, with hypertension being the most commonly represented, followed by diabetes mellitus. 196 patients were discharged after a mean of 9 days, while 14.4% died during hospitalization because of respiratory failure. Age higher than 75 years, low platelet count (<150 × 10(3)/mm(3)) and higher ferritin levels (>750 ng/mL) were independent predictors of death. Comorbidities were not independently associated with in‐hospital mortality. CONCLUSIONS: In‐hospital mortality of patients with COVID‐19 presenting with mild symptoms is high and is associated with older age, platelet count and ferritin levels. Identifying early predictors of outcome can be useful in the clinical practice to better stratify and manage patients with COVID‐19. url: https://www.ncbi.nlm.nih.gov/pubmed/32535885/ doi: 10.1111/eci.13314 id: cord-303703-ekhwb5xb author: Mash, Bob title: Primary care management of the coronavirus (COVID-19) date: 2020-03-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: South Africa is in the grip of a novel coronavirus pandemic (COVID-19). Primary care providers are in the frontline. COVID-19 is spread primarily by respiratory droplets contaminating surfaces and hands that then transmit the virus to another person’s respiratory system. The incubation period is 2–9 days and the majority of cases are mild. The most common symptoms are fever, cough and shortness of breath. Older people and those with cardiopulmonary co-morbidities or immunological deficiency will be more at risk of severe disease. If people meet the case definition, the primary care provider should immediately adopt infection prevention and control measures. Diagnosis is made by a RT-PCR test using respiratory secretions, usually nasopharyngeal and oropharyngeal swabs. Mild cases can be managed at home with self-isolation, symptomatic treatment and follow-up if the disease worsens. Contact tracing is very important. Observed case fatality is between 0.5% and 4%, but may be overestimated as mild cases are not always counted. Primary care providers must give clear, accurate and consistent messages on infection prevention and control in communities and homes. url: https://www.ncbi.nlm.nih.gov/pubmed/32242438/ doi: 10.4102/safp.v62i1.5115 id: cord-304280-2a84u4tm author: Masic, Izet title: Public Health Aspects of COVID-19 Infection with Focus on Cardiovascular Diseases date: 2020-03-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: COVID-19 is the disease caused by an infection of the SARS-CoV-2 virus, first identified in the city of Wuhan, in China’s Hubei province in December 2019. COVID-19 was previously known as 2019 Novel Coronavirus (2019-nCoV) respiratory disease before the World Health Organization (WHO) declared the official name as COVID-19 in February 2020. AIM: The aim of this study is to search scientific literature in the biomedicine and analyzed current results of investigations regarding morbidity and mortality rates as consequences of COVID-19 infection of Cardiovascular diseases (CVD), and other most common chronic diseases which are on the top mortality and morbidity rates in almost all countries in the world. Also, to propose most useful measures how to prevent patients to keep themselves against COVID-19 infection. METHODS: We used method of descriptive analysis of the published papers with described studies about Corona virus connected with CVD, and, also, Guidelines proposed by World Health Organization (WHO) and European Society of Cardiology (ESC), and some other international associations which are included in global fighting against COVID-19 infection. RESULTS: After searching current scientific literature we have acknowledged that not any Evidence Based Medicine (EBM) study in the world during last 5 months from the time when first cases of COVID-10 infection was detected. Also, there is no unique proposed ways of treatments and drugs to protect patients, especially people over 65 years old, who are very risk group to be affected with COVID-19. Expectations that vaccine against COVID-19 will be produced optimal during at least 10 months to 2 years, and in all current Guidelines most important proposed preventive measures are the same like which one described in Strategic documents of WHO, in statements of Declaration of Primary Health Care in Alma Ata in 1978. CONCLUSION: WHO proposed preventive measures can be helpful to everybody. Physicians who work at every level of Health Care Systems, but especially at primary health care level, must follow those recommendations and teach their patients about it. But, the fact is that current focus of COVID-19 epidemic has targeted on protection of physical health of population in global, however, the influence on mental health which will be one of the important consequences of COVID-19 pandemic in the future, and which could be declared as «Post-coronavirus Stress Syndrome„ (PCSS) could be bigger challenge for Global Public Health. url: https://www.ncbi.nlm.nih.gov/pubmed/32410896/ doi: 10.5455/msm.2020.32.71-76 id: cord-018430-u3k8pds6 author: Mason, Jay W. title: Myocarditis date: 2007 words: 21734.0 sentences: 1351.0 pages: flesch: 34.0 cache: ./cache/cord-018430-u3k8pds6.txt txt: ./txt/cord-018430-u3k8pds6.txt summary: The classification states that "myocarditis is diagnosed by established histological, immunological and immunohistochemical criteria." The Dallas criteria 5 provide consensus-derived histologic criteria: "an inflammatory infiltrate of the myocardium with necrosis and/or degeneration of adjacent myocytes not typical of ischemic damage associated with coronary artery disease." However, many have speculated that less pronounced histologic abnormalities may be present and that additional molecular, immunologic, and immunohistochemical diagnostic criteria can be used productively. 330 These criteria define active myocarditis (see also Fig. 59 .7A) as "an inflammatory infiltrate of the myocardium with necrosis and/or degeneration of adjacent myocytes not typical of ischemic damage associated with coronary artery disease." Furthermore, other causes of inflammation (e.g., connective tissue disorders, infection, drugs) should be excluded. 392 An interesting hypothesis to explain the high frequency of dilated heart muscle disease is the presence of myocarditis in HIV-infected patients with left ventricular dysfunction. The ECG abnormalities suggesting myocardial involvement are present in a high proportion of patients, 414 but clinical evidence of cardiac dysfunction occurs in only 10% to 25% of cases. abstract: Viruses are the most common cause of myocarditis in economically advanced countries. Enteroviruses and adenoviruses are the most common etiologic agents. Viral myocarditis is a triphasic process. Phase 1 is the period of active viral replication in the myocardium during which the symptoms of myocardial damage range from none to cardiogenic shock. If the disease process continues, it enters phase 2, which is characterized by autoimmunity triggered by viral and myocardial proteins. Heart failure often appears for the first time in phase 2. Phase 3, dilated cardiomyopathy, is the end result in some patients. Diagnostic procedures and treatment should be tailored to the phase of disease. Viral myocarditis is a significant cause of dilated cardiomyopathy, as proved by the frequent presence of viral genomic material in the myocardium, and by improvement in ventricular function by immunomodulatory therapy. Myocarditis of any etiology usually presents with heart failure, but the second most common presentation is ventricular arrhythmia. As a result, myocarditis is one of the most common causes of sudden death in young people and others without preexisting structural heart disease. Myocarditis can be definitively diagnosed by endomyocardial biopsy. However, it is clear that existing criteria for the histologic diagnosis need to be refined, and that a variety of molecular markers in the myocardium and the circulation can be used to establish the diagnosis. Treatment of myocarditis has been generally disappointing. Accurate staging of the disease will undoubtedly improve treatment in the future. It is clear that immunosuppression and immunomodulation are effective in some patients, especially during phase 2, but may not be as useful in phases 1 and 3. Since myocarditis is often selflimited, bridging and recovery therapy with circulatory assistance may be effective. Prevention by immunization or receptor blocking strategies is under development. Giant cell myocarditis is an unusually fulminant form of the disease that progresses rapidly to heart failure or sudden death. Rapid onset of disease in young people, especially those with other autoimmune manifestations, accompanied by heart failure or ventricular arrhythmias, suggests giant cell myocarditis. Peripartum cardiomyopathy in economically developed countries is usually the result of myocarditis. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123303/ doi: 10.1007/978-1-84628-715-2_62 id: cord-280111-6hiuzkvz author: Maspero, Cinzia title: Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic date: 2020-06-17 words: 6913.0 sentences: 358.0 pages: flesch: 44.0 cache: ./cache/cord-280111-6hiuzkvz.txt txt: ./txt/cord-280111-6hiuzkvz.txt summary: This literature review aims at reducing in-office appointments by providing an overview of the technologies available and their reliability in the long-distance monitoring of patients, i.e., teledentistry. As no reviews have yet been carried out on the efficacy of teleassistance in orthodontics as a way to manage patients at a distance, we would like to report on the evidence available as to the possibility of implementing new technologies in teleassistance, generally known by teleorthodontics to help during the COVID-19 pandemic to remotely monitor patients'' conditions. The attitudes toward teleassistance in orthodontics, and in general, dentistry by respective dental care professionals, was investigated in several studies which confirmed it was as an effective alternative to in-office visits for several routine procedures and to make consultations more accessible to dentists and patients [23, 38] . abstract: Background: COVID-2019 spread rapidly throughout the world from China. This infection is highly contagiousness, has a high morbidity, and is capable of evolving into a potentially lethal form of interstitial pneumonia. Numerous countries shut-down various activities that were considered “not essential.” Dental treatment was in this category and, at the time of writing, only non-deferrable emergencies are still allowed in many countries. Therefore, follow-up visits of ongoing active therapies (e.g., orthodontic treatment) must be handled taking special precautions. This literature review aims at reducing in-office appointments by providing an overview of the technologies available and their reliability in the long-distance monitoring of patients, i.e., teledentistry. Methods: A literature review was made according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. Randomized clinical trials, cross sectional, observational, and case-control studies were evaluated with the Mixed Methods Appraisal Tool for quality assessment and study limitations. Results: A primary search found 80 articles, 69/80 were excluded as non-relevant on the basis of: the abstract, title, study design, bias, and/or lack of relevance. Twelve articles were included in the qualitative analysis. Conclusions: Teleorthodontics can manage most emergencies, reassuring and following patients remotely. The aim set by dental teleassistance was met as it reduced patients’ office visits whilst maintaining regular monitoring, without compromising the results. Although our preliminary findings should be further investigated to objectively evaluate the efficacy, cost-effectiveness, and long-term results, we are confident that teleassistance in orthodontics will have a role to play in the near future. url: https://www.ncbi.nlm.nih.gov/pubmed/32560322/ doi: 10.3390/jcm9061891 id: cord-023669-3ataw6gy author: Masur, Henry title: Critically Ill Immunosuppressed Host date: 2009-05-15 words: 11194.0 sentences: 576.0 pages: flesch: 34.0 cache: ./cache/cord-023669-3ataw6gy.txt txt: ./txt/cord-023669-3ataw6gy.txt summary: As the population of patients with cancer, organ transplants, vasculitides, and human immunodefi ciency virus (HIV) infection has grown, intensivists are seeing more and more patients with altered immunity. For instance, if a patient presents with severe hypoxemia and diffuse pulmonary infi ltrates, a health care provider who recognizes a prior splenectomy as the major predisposition to infection would focus the diagnostic evaluation and the empiric therapy on Streptococcus pneumoniae and Haemophilus infl uenzae. Patients with HIV infection develop clinical disease as a result of three basic processes: the direct effect of HIV on specifi c organs (e.g., cardiomyopathy, enteropathy, dementia); immunologically mediated processes (e.g., glomerulonephritis, thrombocytopenia); or opportunistic infections and tumors that are enabled by HIV-induced immunosuppression. For instance, if a patient with HIV infection and a CD4+ T lymphocyte count of 700 cells/µL presents with diffuse pulmonary infi ltrates, the diagnostic evaluation and empiric antimicrobial regimen should focus on S. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173421/ doi: 10.1016/b978-032304841-5.50056-x id: cord-252101-77lnyjan author: Mathanlal, Thasshwin title: ATMO-Vent: an adapted breathing atmosphere for COVID-19 patients date: 2020-09-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The ongoing worldwide pandemic of coronavirus disease 2019 (COVID-19), has been one of the most significant challenges to humankind in centuries. The extremely contagious nature of the SARS-CoV-2 virus has put forth an immense pressure on the health sector. In order to mitigate the stress on the healthcare systems especially to battle the crisis of mechanical ventilators, we have designed a modular, and robust DIY ventilator, ATMO-Vent (Atmospheric Mixture Optimization Ventilator) which can be fully mounted within two days by two operators. The ATMO-Vent has been designed using low-cost, robust, Commercial Off The Shelf (COTS) components, with many features comparable to a full-fledged ventilator. ATMO-Vent has been designed based on the United Kingdom Medicines & Healthcare products Regulatory Agency (UK-MHRA) guidelines for Rapidly Manufactured Ventilator System (RMVS), yet scalable to the specific requirements of different countries. ATMO-Vent is capable of adjusting the Fraction of Inspiratory Oxygen (FiO(2)) levels, Tidal Volume (TV), frequency of breaths, Inspiratory/Expiratory ratio (I/E), Peak Inspiratory Pressure (PIP) and Positive End-Expiratory Pressure (PEEP). ATMO-Vent can operate in two modes - Continuous Mandatory Ventilation (CMV) using Volume-Controlled Ventilation (VCV) and in Assisted Control (AC) mode with pressure triggered by the patient. ATMO-Vent has undergone rigorous testing and qualifies under Class B Electric and Magnetic Compatibility (EMC) requirements of EN 55011 CISPR 11 standards. url: https://www.sciencedirect.com/science/article/pii/S2468067220300547?v=s5 doi: 10.1016/j.ohx.2020.e00145 id: cord-288271-p074ffpt author: Mathies, D. title: A Case of SARS‐CoV‐2‐pneumonia with successful antiviral therapy in a 77‐year‐old male with heart transplant date: 2020-04-21 words: 2473.0 sentences: 155.0 pages: flesch: 52.0 cache: ./cache/cord-288271-p074ffpt.txt txt: ./txt/cord-288271-p074ffpt.txt summary: In this report, we present a 77‐year old patient with a heart transplant under relevant immunosuppressive therapy who was tested positive for SARS‐CoV‐2 after several days of dyspnoea, dry cough and light general symptoms. All rights reserved Diagnosis: SARS-CoV-2-Infection with viral pneumonia in a patient with heart transplant due to coronary artery disease with ischemic cardiomyopathy In this case the combination of radiologic signs of viral pneumonia and the supposed high-risk state of severe immunosuppression led to the decision to start an antiviral therapy immediately after receiving the positive rtPCR-results although the patient presented only mild symptoms. [13] A second question is whether patients with a solid organ transplant who receive immunosuppressive medication are at greater risk for a severe manifestation of a SARS-CoV 2-Infection or might even benefit from a reduced immunologic reaction. For SARS-CoV 2 we found two cases of patients with a heart transplant of which one had only mild manifestations and one required mechanical ventilation but survived [9] . abstract: The SARS‐CoV‐2‐infection can be seen as a single disease but also affects patients with relevant comorbidities who may have an increased risk of a severe course of infection. In this report, we present a 77‐year old patient with a heart transplant under relevant immunosuppressive therapy who was tested positive for SARS‐CoV‐2 after several days of dyspnoea, dry cough and light general symptoms. The CT‐scan confirmed an interstitial pneumonia. The patient received an antiviral therapy with hydroxychloroquine showing no further deterioration of the clinical state. After 12 days of hospitalisation the patient was released SARS‐CoV‐2 negative and completely asymptomatic. url: https://doi.org/10.1111/ajt.15932 doi: 10.1111/ajt.15932 id: cord-310405-7fah22nu author: Mathur, Sachin title: Development of an enhanced Acute Care Surgery service in response to the COVID-19 global pandemic: Assessment of clinical patient outcomes and staff psychological well-being date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: As the COVID-19 pandemic sweeps across the world, healthcare departments must adapt to meet the challenges of service provision and staff/patient protection. Unlike elective surgery, ACS workloads cannot be artificially reduced providing a unique challenge for administrators to balance healthcare resources between the COVID-19 surge and regular patient admissions. Methods: An enhanced ACS (eACS) model of care is described with the aim of limiting COVID-19 healthcare worker and patient cross-infection as well as providing 24/7 management of emergency general surgical (GS) and trauma patients. The eACS service comprised 5 independent teams covering a rolling 1:5 24-hr call. Attempts to completely separate eACS teams and patients from the elective side were made. The service was compared to the existing ACS service in terms of clinical and efficiency outcomes. Finally, a survey of staff attitudes towards these changes, concerns regarding COVID-19 and psychological well-being was assessed. Results: There were no staff/patient COVID-19 cross-infections. Compared to the ACS service, eACS patients had reduced overall length of stay (2-days), time spent in the Emergency Room (46 minutes) and time from surgery to discharge (2.4-hours). The eACS model of care saved financial resources and bed-days for the organisation. The changes were well received by team-members who also felt that their safety was prioritised. Conclusion: In healthcare systems not overwhelmed by COVID-19, an eACS model may assist in preserving psychological well-being for healthcare staff whilst providing 24/7 care for emergency GS and trauma patients. url: https://www.sciencedirect.com/science/article/pii/S0020138320305477?v=s5 doi: 10.1016/j.injury.2020.06.040 id: cord-302459-grs2x26l author: Matin, Farhana title: A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer date: 2018-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Prostate cancer is diagnosed in over 1 million men every year globally, yet current diagnostic modalities are inadequate for identification of significant cancer and more reliable early diagnostic biomarkers are necessary for improved clinical management of prostate cancer patients. MicroRNAs (miRNAs) modulate important cellular processes/pathways contributing to cancer and are stably present in body fluids. In this study we profiled 372 cancer-associated miRNAs in plasma collected before (~60% patients) and after/during commencement of treatment (~40% patients), from age-matched prostate cancer patients and healthy controls, and observed elevated levels of 4 miRNAs - miR-4289, miR-326, miR-152-3p and miR-98-5p, which were validated in an independent cohort. The miRNA panel was able to differentiate between prostate cancer patients and controls (AUC = 0.88). Analysis of published miRNA transcriptomic data from clinical samples demonstrated low expression of miR-152-3p in tumour compared to adjacent non-malignant tissues. Overexpression of miR-152-3p increased proliferation and migration of prostate cancer cells, suggesting a role for this miRNA in prostate cancer pathogenesis, a concept that was supported by pathway analysis of predicted miR-152-3p target genes. In summary, a four miRNA panel, including miR-152-3p which likely targets genes with key roles in prostate cancer pathogenesis, has the potential to improve early prostate cancer diagnosis. url: https://doi.org/10.1038/s41598-018-24424-w doi: 10.1038/s41598-018-24424-w id: cord-330856-j1wqrc8v author: Matoori, Simon title: Addressing intimate partner violence during the COVID-19 pandemic and beyond: how radiologists can make a difference date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: ABSTRACT: Faced with the COVID-19 pandemic, many countries both in Europe and across the world implemented strict stay-at-home orders. These measures helped to slow the spread of the coronavirus but also led to increased mental and physical health issues for the domestically confined population, including an increase in the occurrence of intimate partner violence (IPV) in many countries. IPV is defined as behavior that inflicts physical, psychological, or sexual harm within an intimate relationship. We believe that as radiologists, we can make a difference by being cognizant of this condition, raising an alert when appropriate and treating suspected victims with care and empathy. The aim of this Special Report is to raise awareness of IPV among radiologists and to suggest strategies by which to identify and support IPV victims. KEY POINTS: • The COVID-19 pandemic led to a marked increase in the number of intimate partner violence (IPV) cases, potentially leading to increased emergency department visits and radiological examinations. • Most IPV-related fractures affect the face, fingers, and upper trunk, and may easily be misinterpreted as routine trauma. • Radiologists should carefully review the medical history of suspicious cases, discuss the suspicion with the referring physician, and proactively engage in a private conversation with the patient, pointing to actionable resources for IPV victims. url: https://doi.org/10.1007/s00330-020-07332-4 doi: 10.1007/s00330-020-07332-4 id: cord-302115-r39ser2c author: Matricardi, Paolo Maria title: The first, holistic immunological model of COVID‐19: implications for prevention, diagnosis, and public health measures date: 2020-05-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The natural history of COVID‐19 caused by SARS‐CoV‐2 is extremely variable, ranging from asymptomatic or mild infection, mainly in children, to multi‐organ failure, eventually fatal, mainly in the eldest. We propose here the first model, explaining how the outcome of first, crucial 10‐15 days after infection, hangs on the balance between the cumulative dose of viral exposure and the efficacy of the local innate immune response (natural IgA and IgM antibodies, Mannose Binding Lectin ). If SARS‐CoV‐2 runs the blockade of this innate immunity and spreads from the upper airways to the alveoli in the early phases of the infections, it can replicate with no local resistance, causing pneumonia and releasing high amounts of antigens. The delayed and strong adaptive immune response (high affinity IgM and IgG antibodies) that follows, causes severe inflammation and triggers mediator cascades (complement, coagulation, and cytokine storm) leading to complications often requiring intensive therapy and being, in some patients, fatal. Low‐moderate physical activity can still be recommended. However, extreme physical activity and hyperventilation during the incubation days and early stages of COVID‐19, facilitates early direct penetration of high numbers of virus particles in the lower airways and the alveoli, without impacting on the airway’s mucosae covered by neutralizing antibodies. This allows the virus bypassing the efficient immune barrier of the upper airways mucosa in already infected, young and otherwise healthy athletes. In conclusion, whether the virus or the adaptative immune response reach the lungs first, is a crucial factor deciding the fate of the patient. This “quantitative and time‐sequence dependent” model has several implications for prevention, diagnosis, and therapy of COVID‐19 at all ages. url: https://doi.org/10.1111/pai.13271 doi: 10.1111/pai.13271 id: cord-004310-hl7fa4af author: Matsuishi, Yujiro title: Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients date: 2020-02-10 words: 3488.0 sentences: 187.0 pages: flesch: 48.0 cache: ./cache/cord-004310-hl7fa4af.txt txt: ./txt/cord-004310-hl7fa4af.txt summary: We recorded patient information, including age, sex, surgical procedure, and daily severity data (including severity of organ dysfunction and sedative/muscle relaxant dosages) during PICU stays for five days after the end of muscle relaxant usage. We found that, overall, the amount of MDZ administered was increased in DS versus controls after ending muscle relaxants and observed the reduced sedative effect of MDZ for DS patients while DEX was not different as estimated by Bayesian inference modeling. To adjust these biases, we used multivariate www.nature.com/scientificreports www.nature.com/scientificreports/ analysis with respect to these factors but we also "double checked" our results by using the demographic data propensity score for DS patients as a covariate in Bayesian inference modeling. To conclude, we conducted a retrospective study based on validated evaluative tools that indicated a need for higher doses of MDZ with higher doses of compensating sedatives for the 5-day period immediately after muscle relaxant usage following pediatric heart surgery. abstract: Down syndrome (DS) is frequently comorbid with congenital heart disease and has recently been shown to reduce the sedative effect of benzodiazepine (BDZ)-class anesthesia but this effect in a clinical setting has not been studied. Therefore, this study compared midazolam sedation after heart surgery in DS and normal children. We retrospectively reviewed patient records in our pediatric intensive care unit (PICU) of pediatric cardiovascular operations between March 2015 and March 2018. We selected five days of continuous post-operative data just after termination of muscle relaxants. Midazolam sedation was estimated by Bayesian inference for generalized linear mixed models. We enrolled 104 patients (average age 26 weeks) of which 16 (15%) had DS. DS patients had a high probability of receiving a higher midazolam dosage and dexmedetomidine dosage over the study period (probability = 0.99, probability = 0.97) while depth of sedation was not different in DS patients (probability = 0.35). Multi regression modeling included severity scores and demographic data showed DS decreases midazolam sedation compared with controls (posterior OR = 1.32, 95% CrI = 1.01–1.75). In conclusion, midazolam dosages should be carefully adjusted as DS significantly decreases midazolam sedative effect in pediatric heart surgery patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010829/ doi: 10.1038/s41598-020-58283-1 id: cord-012459-tge08va0 author: Matthews, Laura J. title: Airway Alert Bracelets: Enhancing Safety in the Coronavirus Disease 2019 Era date: 2020-08-18 words: 626.0 sentences: 35.0 pages: flesch: 51.0 cache: ./cache/cord-012459-tge08va0.txt txt: ./txt/cord-012459-tge08va0.txt summary: We have designed a medical alert bracelet, similar to a hospital name band, that is placed on any patient where nonstandard equipment (anything other than iView video laryngoscope [Intersurgical, Wokingham, England] plus bougie) was needed to secure the airway or where the person intubating experienced difficulty. They then remain on the patient''s wrist for the duration of their ICU stay and provide a visual alert of their difficult airway, regardless of the bed space or even hospital if they are transferred for ongoing care (Figure) . The presence of this bracelet on a patient prompts a review of the electronic intubation notes before undertaking any procedure where the airway could be "at risk," and appropriate measures to be put in place-for example, a senior anesthetist with the relevant equipment present when airway alert patients are proned or deproned. Airway Alert Bracelets: Enhancing Safety in the Coronavirus Disease 2019 Era Figure. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437420/ doi: 10.1213/ane.0000000000005165 id: cord-032392-ex3s8evv author: Matthews, Tamyra title: Single cases from multiple perspectives: a qualitative study comparing the experiences of patients, patients’ caregivers, surgeons, and nurses when bad news is delivered about cancer date: 2020-09-18 words: 6761.0 sentences: 345.0 pages: flesch: 58.0 cache: ./cache/cord-032392-ex3s8evv.txt txt: ./txt/cord-032392-ex3s8evv.txt summary: Interpretative phenomenological analysis (IPA) provided the theoretical framework to examine semistructured interviews exploring participants'' lived experiences of the breaking bad news process, and then to directly compare patients'', caregivers'', and HCPs'' accounts that were linked to the same patient''s case. The current study sample was determined by the number of linked cases that were able to be formed from the data collected for a larger doctoral study exploring the perspectives of 4 different groups involved in the bad news process: patients, caregivers, surgeons, and nurses. In linked cases that included the bad news deliverer and receiver perspective, the direct comparison highlighted the importance of HCPs recognizing and attending to patients'' and caregivers'' specific emotional needs ("noticing and meeting emotional needs") and delivering information in the way that suited each patient ("reading different informational needs"). abstract: BACKGROUND: Qualitative literature on the experiences of those delivering and receiving bad news about cancer has revealed what these parties consider important during the process across many different patient cases. The current study aims to add to this understanding by employing a “linked case" study design to directly compare the perspectives of patients, their caregivers, and health care professionals (HCPs) involved in a series of single-patient cases of breaking bad news. METHOD: Semistructured interviews were conducted with 13 participants (5 patients, 4 caregivers, 2 surgeons, and 2 nurses) who formed 5 linked cases. Interviews were analyzed using interpretative phenomenological analysis and directly compared within each linked case. RESULTS: Analyses identified 2 main superordinate themes. The first labeled “accurately perceiving and responding to needs," included HCPs recognizing and responding to patients’ and caregivers’ individual emotional and informational needs. The second labeled “carers fulfilling necessary roles," identified the various roles HCPs and patients’ caregivers took to satisfactorily meet patients’ needs. CONCLUSIONS: The findings suggest the importance of HCPs accurately perceiving and responding to patients’ and caregivers’ various needs and caregivers ability and willingness to fulfilling support roles in a way that aligns with their own resources and patients’ needs. This highlights the value of HCPs developing and applying interpersonal skills within bad news encounters, working as a team, and exploring caregivers’ resources for patient support. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505030/ doi: 10.1097/or9.0000000000000032 id: cord-333528-9mczqtje author: Mattogno, P. P. title: Transnasal endoscopic skull base surgery during COVID-19 pandemic: algorithm of management in an Italian reference COVID center date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s00701-020-04414-6 doi: 10.1007/s00701-020-04414-6 id: cord-287901-56goaqir author: Maudgil, D.D. title: Cost effectiveness and the role of the National Institute of Health and Care Excellence (NICE) in interventional radiology date: 2020-10-17 words: 5021.0 sentences: 276.0 pages: flesch: 46.0 cache: ./cache/cord-287901-56goaqir.txt txt: ./txt/cord-287901-56goaqir.txt summary: Costs for the same procedure can vary widely, e.g., the "Getting it Right First Time" (GIRFT) Vascular Surgery report noted that reported cost for elective endovascular aortic repair (EVAR) varied between £2,251 and £19,690 for no apparent reason and with no indication that lower cost procedures were less effective 2,4 ; CES encompass a wider societal perspective than just the clinician''s or patient''s point of view alone, helping demonstrate equitable resource allocation in a publicly funded service 3 ; CES allow evaluation of short-and long-term costs and benefits, which are often under-or overestimated; and 4 CES provide an explicit and accountable framework for decision making, which can be re-examined as data accumulate, particularly important with evolving techniques and experience as in interventional radiology (IR). abstract: Healthcare expenditure is continually increasing and projected to accelerate in the future, with an increasing proportion being spent on interventional radiology. The role of cost effectiveness studies in ensuring the best allocation of resources is discussed, and the role of National Institute of Health and Care Excellence (NICE) in determining this. Issues with demonstrating cost effectiveness have been discussed, and it has been found that there is significant scope for improving cost effectiveness, with suggestions made for how this can be achieved. In this way, more patients can benefit from better treatment given limited healthcare budgets. url: https://www.sciencedirect.com/science/article/pii/S000992602030427X doi: 10.1016/j.crad.2020.09.017 id: cord-259907-yqmi0cqy author: Maxwell, Cynthia title: Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) No. 225, April 2009 date: 2009-10-31 words: 3419.0 sentences: 211.0 pages: flesch: 49.0 cache: ./cache/cord-259907-yqmi0cqy.txt txt: ./txt/cord-259907-yqmi0cqy.txt summary: title: Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) No. 225, April 2009 Labour triage and antenatal hospital admission Actions • Assessment is made as to whether the patient has suspected or probable SARS [1, 14] • Upon arrival in the labour and delivery triage unit, pregnant patients presenting with fever N38°C and respiratory symptoms and one of the associated symptoms (cough, unexplained hypoxia, shortness of breath, or dyspnea) and history of an exposure to an individual with probable SARS are immediately transferred to the designated isolation room, which is equipped with negative pressure ventilation. • Parents and family are counselled to look for symptoms and signs of SARS in the mother and newborn, especially in the first 10 days following delivery, and to report to any findings to the health care team Summary SARS, a life-threatening respiratory illness caused by a novel coronavirus, was responsible for a worldwide outbreak in 2003. abstract: Abstract Objective This document summarizes the limited experience of SARS in pregnancy and suggests guidelines for management. Outcomes Cases reported from Asia suggest that maternal and fetal outcomes are worsened by SARS during pregnancy. Evidence Medline was searched for relevant articles published in English from 2000 to 2007. Case reports were reviewed and expert opinion sought. Values Recommendations were made according to the guidelines developed by the Canadian Task Force on Preventive Health Care. url: https://www.ncbi.nlm.nih.gov/pubmed/19780222/ doi: 10.1016/j.ijgo.2009.05.006 id: cord-347255-fl9lur4h author: May, Larissa title: Rapid Multiplex Testing for Upper Respiratory Pathogens in the Emergency Department: A Randomized Controlled Trial date: 2019-11-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Acute upper respiratory tract infections are a common cause of emergency department (ED) visits and often result in unnecessary antibiotic treatment. METHODS: We conducted a randomized clinical trial to evaluate the impact of a rapid, multipathogen respiratory panel (RP) test vs usual care (control). Patients were eligible if they were ≥12 months old, had symptoms of upper respiratory infection or influenza-like illness, and were not on antibiotics. The primary outcome was antibiotic prescription; secondary outcomes included antiviral prescription, disposition, and length of stay (ClinicalTrials.gov# NCT02957136). RESULTS: Of 191 patients enrolled, 93 (49%) received RP testing; 98 (51%) received usual care. Fifty-three (57%) RP and 7 (7%) control patients had a virus detected and reported during the ED visit (P = .0001). Twenty (22%) RP patients and 33 (34%) usual care patients received antibiotics during the ED visit (–12%; 95% confidence interval, –25% to 0.4%; P = .06/0.08); 9 RP patients received antibiotics despite having a virus detected. The magnitude of antibiotic reduction was greater in children (–19%) vs adults (–9%, post hoc analysis). There was no difference in antiviral use, length of stay, or disposition. CONCLUSIONS: Rapid RP testing was associated with a trend toward decreased antibiotic use, suggesting a potential benefit from more rapid viral tests in the ED. Future studies should determine if specific groups are more likely to benefit from testing and evaluate the relative cost and effectiveness of broad testing, focused testing, and a combined diagnostic and antimicrobial stewardship approach. url: https://www.ncbi.nlm.nih.gov/pubmed/32128326/ doi: 10.1093/ofid/ofz481 id: cord-003404-eqgc8v7y author: May, Win Lai title: Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children date: 2019-01-02 words: 4930.0 sentences: 289.0 pages: flesch: 55.0 cache: ./cache/cord-003404-eqgc8v7y.txt txt: ./txt/cord-003404-eqgc8v7y.txt summary: We aimed to determine the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar. In vitro studies reported that monocytes from G6PD-deficient individuals had increased susceptibility to dengue virus serotype 2 infections along with higher viral replication [5, 6] . Herein, we investigated the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar. Out of 212 enrolled patients, 16 were excluded (2 did not have Glucose-6-phosphate dehydrogenase deficiency on dengue infection in children sufficient blood volume, 11 had a negative dengue result, and 3 lacked quantitative G6PD results). Severe dengue was not associated with a G6PD deficiency phenotype nor genotype variants whether we used a cut off of < 30% (i.e. only including hemizygous males and homozygous females) or a cut off of < 60%, corresponding to classes I to III of the WHO classification (Table 5) . abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency may affect the clinical presentation of dengue due to the altered redox state in immune cells. We aimed to determine the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar. A cross-sectional study was conducted among paediatric patients aged 2–13 years with dengue in Yankin Children Hospital, Myanmar. One hundred and ninety-six patients positive for dengue infection, as determined via PCR or ELISA, were enrolled. Dengue severity was determined according to the 2009 WHO classification guidelines. Spectrophotometric assays determined G6PD levels. The adjusted median G6PD value of males in the study population was used to define various cut-off points according to the WHO classification guidelines. G6PD genotyping for Mahidol, Kaiping and Mediterranean mutations was performed for 128 out of 196 samples by real-time multiplex PCR. 51 of 196 (26.0%) patients had severe dengue. The prevalence of G6PD phenotype deficiency (< 60% activity) in paediatric patients was 14.8% (29/196), specifically, 13.6% (14/103) in males and 16.2% (15/93) in females. Severe deficiency (< 10% activity) accounted for 7.1% (14/196) of our cohort, occurring 11.7% (12/103) in males and 2.2% (2/93) in females. Among 128 samples genotyped, the G6PD gene mutations were detected in 19.5% (25/128) of patients, with 20.3% (13/ 64) in males and 18.8% (12/64) in females. The G6PD Mahidol mutation was 96.0% (24/25) while the G6PD Kaiping mutation was 4.0% (1/25). Severe dengue was not associated with G6PD enzyme deficiency or presence of the G6PD gene mutation. Thus, no association between G6PD deficiency and dengue severity could be detected. Trial registration: The study was registered following the WHO International Clinical Trials Registry Platform (WHO-ICTRP) on Thai Clinical Trials Registry (TCTR) website, registration number # TCTR20180720001 url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314580/ doi: 10.1371/journal.pone.0209204 id: cord-254990-nrzwn6oz author: Mayer, Kirby P. title: Recovery from COVID-19 and acute respiratory distress syndrome: the potential role of an intensive care unit recovery clinic: a case report date: 2020-09-10 words: 3117.0 sentences: 169.0 pages: flesch: 49.0 cache: ./cache/cord-254990-nrzwn6oz.txt txt: ./txt/cord-254990-nrzwn6oz.txt summary: The purpose of this case report is to highlight the potential role of intensive care unit recovery or follow-up clinics for patients surviving acute hospitalization for coronavirus disease 2019. CASE PRESENTATION: Our patient was a 27-year-old Caucasian woman with a past medical history of asthma transferred from a community hospital to our medical intensive care unit for acute hypoxic respiratory failure due to bilateral pneumonia requiring mechanical ventilation (ratio of arterial oxygen partial pressure to fraction of inspired oxygen, 180). CONCLUSION: We present this case report to suggest that patients surviving coronavirus disease 2019 with subsequent development of acute respiratory distress syndrome will require more intense intensive care unit recovery follow-up. The patient''s family reported no travel history or exposure risk, but, given the Fig. 1 Chest radiograph obtained on day 1 of admission to intensive care unit revealed bibasilar airspace disease patient''s clinical symptoms, a test for COVID-19 was performed. abstract: BACKGROUND: In this case report, we describe the trajectory of recovery of a young, healthy patient diagnosed with coronavirus disease 2019 who developed acute respiratory distress syndrome. The purpose of this case report is to highlight the potential role of intensive care unit recovery or follow-up clinics for patients surviving acute hospitalization for coronavirus disease 2019. CASE PRESENTATION: Our patient was a 27-year-old Caucasian woman with a past medical history of asthma transferred from a community hospital to our medical intensive care unit for acute hypoxic respiratory failure due to bilateral pneumonia requiring mechanical ventilation (ratio of arterial oxygen partial pressure to fraction of inspired oxygen, 180). On day 2 of her intensive care unit admission, reverse transcription–polymerase chain reaction confirmed coronavirus disease 2019. Her clinical status gradually improved, and she was extubated on intensive care unit day 5. She had a negative test result for coronavirus disease 2019 twice with repeated reverse transcription–polymerase chain reaction before being discharged to home after 10 days in the intensive care unit. Two weeks after intensive care unit discharge, the patient returned to our outpatient intensive care unit recovery clinic. At follow-up, the patient endorsed significant fatigue and exhaustion with difficulty walking, minor issues with sleep disruption, and periods of memory loss. She scored 10/12 on the short performance physical battery, indicating good physical function. She did not have signs of anxiety, depression, or post-traumatic stress disorder through self-report questionnaires. Clinically, she was considered at low risk of developing post–intensive care syndrome, but she required follow-up services to assist in navigating the healthcare system, addressing remaining symptoms, and promoting return to her pre–coronavirus disease 2019 societal role. CONCLUSION: We present this case report to suggest that patients surviving coronavirus disease 2019 with subsequent development of acute respiratory distress syndrome will require more intense intensive care unit recovery follow-up. Patients with a higher degree of acute illness who also have pre-existing comorbidities and those of older age who survive mechanical ventilation for coronavirus disease 2019 will require substantial post–intensive care unit care to mitigate and treat post–intensive care syndrome, promote reintegration into the community, and improve quality of life. url: https://www.ncbi.nlm.nih.gov/pubmed/32912329/ doi: 10.1186/s13256-020-02481-y id: cord-277201-jzjxsetx author: Mazo, Jahinover title: More than Just Pneumonia: Acute Pulmonary Embolism in Two Middle-Aged Patients with COVID-19 date: 2020-07-30 words: 2648.0 sentences: 141.0 pages: flesch: 40.0 cache: ./cache/cord-277201-jzjxsetx.txt txt: ./txt/cord-277201-jzjxsetx.txt summary: We suspect that a prothrombotic inflammatory response provoked by coronavirus disease could be the culprit, acting as an additive effect on middle-aged patients with known risk factors for venous thromboembolism. In addition to coagulation factor abnormalities, other reported findings of increased D-dimers, ferritin, and lactate dehydrogenase further support the assertion that a prothrombotic response to the virus is driving the thromboembolic events among COVID-19 patients [9] . Severe COVID-19 infections have also been associated with an inflammatory prothrombotic state, also potentially playing a key role behind the increase in reported thromboembolic complications. We suspect that the existing risk factors present along with the superimposed prothrombotic state induced by COVID-19 induced inflammatory response may have precipitated the development of the venous thromboembolism resulting in PE. e CHEST Guideline and Expert Panel Report on management of venous thromboembolism (VTE) in COVID-19 patients outlines various recommendations for management of acute VTE. abstract: BACKGROUND: Although severe pneumonia and respiratory compromise have remained the predominant complications of coronavirus disease 19, we are now learning this virus is much more varied in its presentation. In particular, there are increasingly reported cases of thromboembolic events occurring in infected patients. Case Report. In this report, we present two patients, both under the age of 40 with known risk factors for venous thromboembolism, who presented with respiratory distress. Both patients were diagnosed with SARS-CoV-2 pneumonia and pulmonary embolism requiring management with anticoagulation. Both patients were discharged after a short course in the hospital. CONCLUSION: The discussion of a hypercoagulable state induced by coronavirus disease 19 has been well documented; however, the exact mechanisms remain unknown. We suspect that a prothrombotic inflammatory response provoked by coronavirus disease could be the culprit, acting as an additive effect on middle-aged patients with known risk factors for venous thromboembolism. We recommend clinicians closely monitor those with known risk factors for pulmonary embolism. url: https://doi.org/10.1155/2020/4812036 doi: 10.1155/2020/4812036 id: cord-340314-5oz3013n author: Mazzitelli, Maria title: Use of subcutaneous tocilizumab in patients with COVID‐19 pneumonia date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Over the last months, pandemic SARS‐CoV‐2 caused a significant challenge for clinicians. Unfortunately, no approved and validated treatments are available. Intravenous tocilizumab, an antirheumatic drug, seems to be promising in counteracting cytokine storm caused by SARS‐CoV‐2 infection with associated clinical improvements. We report herein a case series of patients with COVID‐19 pneumonia who were treated with tocilizumab administrated, for the first time, subcutaneously with good clinical and radiological outcomes. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32410234/ doi: 10.1002/jmv.26016 id: cord-256109-dkp0fwe3 author: Mazzulli, Tony title: Severe Acute Respiratory Syndrome–associated Coronavirus in Lung Tissue date: 2004-01-17 words: 2554.0 sentences: 115.0 pages: flesch: 53.0 cache: ./cache/cord-256109-dkp0fwe3.txt txt: ./txt/cord-256109-dkp0fwe3.txt summary: Efforts to contain severe acute respiratory syndrome (SARS) have been limited by the lack of a standardized, sensitive, and specific test for SARS-associated coronavirus (CoV). Efforts to contain severe acute respiratory syndrome (SARS) have been limited by the lack of a standardized, sensitive, and specific test for SARS-associated coronavirus (CoV). All patients who met the current World Health Organization case definition of probable SARS and who underwent a postmortem examination in Canada during the March-April 2003 outbreak were included in this study. The clinical description and RT-PCR results for the 11 patients with probable SARS from whom postmortem lung tissue samples were examined are summarized in Table 1 . By using a standardized RT-PCR assay, SARS-CoV has been unequivocally identified in the lung tissue of all patients who died with probable SARS but not in any of the controls. abstract: Efforts to contain severe acute respiratory syndrome (SARS) have been limited by the lack of a standardized, sensitive, and specific test for SARS-associated coronavirus (CoV). We used a standardized reverse transcription-polymerase chain reaction assay to detect SARS-CoV in lung samples obtained from well-characterized patients who died of SARS and from those who died of other reasons. SARS-CoV was detected in all 22 postmortem lung tissues (to 10(9) viral copies/g) from 11 patients with probable SARS but was not detected in any of the 23 lung control samples (sample analysis was blinded). The sensitivity and specificity (95% confidence interval) were 100% (84.6% to 100%) and 100% (85.1% to 100%), respectively. Viral loads were significantly associated with a shorter course of illness but not with the use of ribavirin or steroids. CoV was consistently identified in the lungs of all patients who died of SARS but not in control patients, supporting a primary role for CoV in deaths. url: https://www.ncbi.nlm.nih.gov/pubmed/15078592/ doi: 10.3201/eid1001.030404 id: cord-284454-malfatni author: McCall, W. Travis title: Caring for Patients From a School Shooting: A Qualitative Case Series in Emergency Nursing date: 2020-08-19 words: 5449.0 sentences: 283.0 pages: flesch: 48.0 cache: ./cache/cord-284454-malfatni.txt txt: ./txt/cord-284454-malfatni.txt summary: [5] [6] [7] [8] Therefore, providing care to patients who are injured during school-associated shooting events is likely to be particularly stressful for emergency nurses. The purpose of this study was to learn how emergency nurses describe their experiences to identify themes and findings that may translate to practices for improving the mental health and wellness of emergency nurses who care for patients from a multicasualty, school-associated shooting incident. Another participant predicted that community or critical access emergency departments receiving patients from a multicasualty school shooting event may experience even greater emotional challenges because these departments are more likely to have staff who may personally know the victims or their families. Learning from emergency nurses who care for patients from a multicasualty, school-associated shooting event may promote personal and departmental preparedness and improve coping and recovery among the involved clinicians. abstract: INTRODUCTION: Emergency nurses are at risk for secondary traumatic stress, compassion fatigue, and burnout as a result of witnessing the trauma and suffering of patients. The traumatic events perceived as being most stressful for emergency nurses involve sudden death, children, and adolescents. Multicasualty, school-associated shooting events are, therefore, likely to affect emergency nurses, and recent reports indicate an increase in multicasualty, school-associated shootings. This research is necessary to learn of emergency nurses’ experiences of caring for patients from a school shooting event in an effort to benefit future preparedness, response, and recovery. This manuscript describes these experiences and provides opportunities for nurses, peers, and leaders to promote mental health and resilience among emergency nurses who may provide care to patients after such events. METHODS: A qualitative case series approach, a theory of secondary traumatic stress, and the compassion fatigue resilience model guided the research. The emergency nurses who provided care to patients who were injured during a 2018 multicasualty, school-associated shooting in the Southeastern United States were invited to participate. RESULTS: The themes identified by this research with 7 participants were preparation and preparedness, coping and support mechanisms, and reflections and closure. DISCUSSION: The results identified through this research may be translated to policies and practice to improve emergency nurses’ welfare, coping, resilience, and retention. Patient outcomes may also be improved through planning and preparedness. url: https://www.ncbi.nlm.nih.gov/pubmed/32828487/ doi: 10.1016/j.jen.2020.06.005 id: cord-312063-5c2w2ct1 author: McCollum, Lauren title: Cognitive Impairment Evaluation and Management date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Clinicians should use a systematic approach to evaluating patients presenting with a concern for cognitive impairment. This approach includes interviewing a knowledgeable informant and performing a thorough mental status examination in order to determine the presence of functional impairments and the domains of cognition that are impaired. The results of this interview and examination determine the next steps of the diagnostic work-up. The pattern of cognitive impairment shapes the differential diagnosis. Treatment should address symptoms, and environmental, psychological, and behavioral interventions are essential. url: https://doi.org/10.1016/j.mcna.2020.06.007 doi: 10.1016/j.mcna.2020.06.007 id: cord-342857-vj6sw2ne author: McCullough, Peter A. title: Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Approximately 9 months of the SARS-CoV-2 virus spreading across the globe has led to widespread COVID-19 acute hospitalizations and death. The rapidity and highly communicable nature of the SARS-CoV-2 outbreak has hampered the design and execution of definitive randomized, controlled trials of therapy outside of the clinic or hospital. In the absence of clinical trial results, physicians must use what has been learned about the pathophysiology of SARS-CoV-2 infection in determining early outpatient treatment of the illness with the aim of preventing hospitalization or death. This paper outlines key pathophysiological principles that relate to the patient with early infection treated at home. Therapeutic approaches based on these principles include: 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy 5) administration of oxygen, monitoring, and telemedicine. Future randomized trials testing the principles and agents discussed in this paper will undoubtedly refine and clarify their individual roles, however we emphasize the immediate need for management guidance in the setting of widespread hospital resource consumption, morbidity, and mortality. url: https://doi.org/10.1016/j.amjmed.2020.07.003 doi: 10.1016/j.amjmed.2020.07.003 id: cord-318803-xpa49sxt author: McFee, Robin B. title: Gulf War Servicemen and Servicewomen: The Long Road Home and the Role of Health Care Professionals to Enhance the Troops' Health and Healing date: 2008-05-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/18440371/ doi: 10.1016/j.disamonth.2008.02.002 id: cord-324007-hapzf0fl author: McGeer, Allison J. title: Diagnostic Testing or Empirical Therapy for Patients Hospitalized with Suspected Influenza: What to Do? date: 2009-01-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Accumulating evidence supports the use of specific diagnostic tests and antiviral therapies for seriously ill patients with influenza. Among available diagnostic tests, reverse-transcriptase polymerase chain reaction is faster than culture and more sensitive than commercial antigen assays. Current neuraminidase inhibitors were approved on the basis of their efficacy in ambulatory patients, but seriously ill patients who receive these agents are less likely to die, even when treatment is initiated >48 h after symptom onset. For patients hospitalized with suspected influenza, it is unclear which circumstances warrant diagnostic testing and which warrant the use of empirical therapy. Rapid antigen assays may reduce the unnecessary use of other tests and medications but are relatively insensitive, thus eliminating many patients with influenza as candidates for treatment. Empirical antiviral therapy ensures that all patients receive treatment promptly, at a cost equivalent to that of diagnostic tests alone, but results in the receipt of treatment by many patients without influenza. For patients hospitalized with suspected influenza, clinicians need to combine these approaches in order to optimize patient care. url: https://doi.org/10.1086/591852 doi: 10.1086/591852 id: cord-332087-xwturwju author: McGlynn, Fergal title: Argatroban for therapeutic anticoagulation for heparin resistance associated with Covid-19 infection date: 2020-08-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32830309/ doi: 10.1007/s11239-020-02251-z id: cord-287161-hqrql1lh author: McGrail, D. E. title: COVID-19 Case Series at UnityPoint Health St. Lukes Hospital in Cedar Rapids, IA date: 2020-07-19 words: 2237.0 sentences: 146.0 pages: flesch: 48.0 cache: ./cache/cord-287161-hqrql1lh.txt txt: ./txt/cord-287161-hqrql1lh.txt summary: A retrospective, descriptive study of all patients tested for SARS-CoV2 on admission for illness to a community hospital in Iowa from 3/21/20 thru 6/14/20 consisted of evaluation as to demographics, presentation and hospital course. Overall survival of the COVID-19 patients was 88%, 77% in the critically ill, 59% of those mechanically ventilated and 33% of those requiring new dialysis. In this case series, we aim to describe epidemiological, clinical, laboratory, and treatment outcomes of confirmed COVID-19 patients admitted 3/21/2020 thru 6/14/2020 to UPH St. Luke''s Hospital, one of the two hospitals in Cedar Rapids. This early peak in ICU resources is a reflection of transitioning from an early intubation intervention for COVID-19 related acute hypoxic respiratory failure to a strategy of utilizing high flow nasal cannula and noninvasive ventilation(i.e BiPAP) as supported in the literature 15 . In addition, our data indicates a significant portion of the critically ill patients whom were mechanically ventilated required hemodialysis support, 47%(9 of 19). abstract: A retrospective, descriptive study of all patients tested for SARS-CoV2 on admission for illness to a community hospital in Iowa from 3/21/20 thru 6/14/20 consisted of evaluation as to demographics, presentation and hospital course. Ninety-one patients were SARS-CoV2 PCR+ with 63% being male and a median age of 60. Cardiovascular disease was a significant comorbidity in the PCR+ group. Fever, cough, dyspnea, nausea, emesis, diarrhea, headache and myalgias were significantly more common in that group, as was an elevated CRP, LDH, serum ferritin and transaminases. Overall survival of the COVID-19 patients was 88%, 77% in the critically ill, 59% of those mechanically ventilated and 33% of those requiring new dialysis. Survival was 93% in those not receiving any antivirals. Survival of those treated with hydroxychloroquine-azithromycin was 92%, compared to 86% of those treated with hydroxychloroquine alone. The latter two groups were significantly more ill than the untreated group. A transition from an early intubation strategy to aggressive utilization of high flow nasal cannula and noninvasive ventilation(i.e BiPAP) was successful in freeing up ICU resources. url: http://medrxiv.org/cgi/content/short/2020.07.17.20156521v1?rss=1 doi: 10.1101/2020.07.17.20156521 id: cord-333808-deifddar author: McGregor, Bradley A title: Remote Oncology Care: Review of Current Technology and Future Directions date: 2020-08-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Cancer patients frequently develop tumor and treatment-related complications, leading to diminished quality of life, shortened survival, and overutilization of emergency department and hospital services. Outpatient oncology treatment has potential to leave cancer patients unmonitored for long periods while at risk of clinical deterioration which has been exaggerated during the COVID19 pandemic. Visits to cancer clinics and hospitals risk exposing immunocompromised patients to infectious complications. Remote patient reported outcomes monitoring systems have been developed for use in cancer treatment, showing benefits in economic and survival outcomes. While advanced devices such as pulmonary artery pressure monitors and implantable loop recorders have proven benefits in cardiovascular care, similar options do not exist for oncology. Here we review the current literature around remote patient monitoring in cancer care and propose the use of reliable devices for capturing and reporting patient symptoms and physiology. url: https://www.ncbi.nlm.nih.gov/pubmed/33014652/ doi: 10.7759/cureus.10156 id: cord-347697-uz0i6wfp author: McLean, Ross C. title: A single-centre observational cohort study to evaluate volume and severity of emergency general surgery admissions during the COVID-19 pandemic: is there a “lockdown” effect? date: 2020-09-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The COVID-19 pandemic has led to changes in NHS surgical service provision, including reduced elective surgical and endoscopic activity, with only essential emergency surgery being undertaken. This, combined with the government-imposed lockdown, may have impacted on patient attendance, severity of surgical disease, and outcomes. The aim of this study was to investigate a possible ‘lockdown’ effect on the volume and severity of surgical admissions and their outcomes. METHODS: Two separate cohorts of adult emergency general surgery inpatient admissions 30 days immediately before (16(th) February 2020 to 15(th) March 2020), and after UK government advice (16(th) March 2020 to 15(th) April 2020). Data were collected relating to patient characteristics, severity of disease, clinical outcomes, and compared between these groups. RESULTS: Following lockdown, a significant reduction in median daily admissions from 7 to 3 per day (p<0.001) was observed. Post-lockdown patients were significantly older, frailer with higher inflammatory indices and rates of acute kidney injury, and also were significantly more likely to present with gastrointestinal cancer, obstruction, and perforation. Patients had significantly higher rates of Clavien-Dindo Grade ≥3 complications (p=0.001), all cause 30-day mortality (8.5% vs. 2.9%, p=0.028), but no significant difference was observed in operative 30-day mortality. CONCLUSION: There appears to be a “lockdown” effect on general surgical admissions with a profound impact; fewer surgical admissions, more acutely unwell surgical patients, and an increase in all cause 30-day mortality. Patients should be advised to present promptly with gastrointestinal symptoms, and this should be reinforced for future lockdowns during the pandemic. url: https://www.sciencedirect.com/science/article/pii/S1743919120306749?v=s5 doi: 10.1016/j.ijsu.2020.09.011 id: cord-316835-qf0c91vr author: McLeod, Jacob M. title: Nontraumatic Osteonecrosis of the Distal Tibia: A Case Presentation and Review of the Literature date: 2016-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Osteonecrosis, although commonly occurring in the hip, can also affect the leg and foot. In the foot, it most commonly occurs in the talus. The incidence of osteonecrosis occurring in the tibia is relatively rare. We report a case of a woman who presented to our clinic with ankle pain that was idiopathic in nature. Subsequent magnetic resonance imaging showed findings consistent with osteonecrosis of the bilateral distal tibias and several other lesions located in the shoulder, hip, and calcaneus. The present report also serves as a review of both etiology and treatment of osteonecrosis as it relates to the lower extremity. url: https://www.ncbi.nlm.nih.gov/pubmed/27545513/ doi: 10.1053/j.jfas.2016.04.001 id: cord-018809-3nrvm4jt author: McMullin, N. R. title: Hemostatic Resuscitation date: 2006 words: 6231.0 sentences: 294.0 pages: flesch: 46.0 cache: ./cache/cord-018809-3nrvm4jt.txt txt: ./txt/cord-018809-3nrvm4jt.txt summary: In combat, fresh whole blood for massive transfusion becomes a blood bank multiplier, providing within a single unit, RBCs, volume, coagulation components, and functional platelets in a warm fluid. Appropriate use following established guidelines can be beneficial and may even be superior to packed RBCs. A fluid containing the vital properties of fresh whole blood would serve as a bridge to allow a patient to be resuscitated without initiating the''bloody cycle of death'' that is seen all too often in our current paradigm of massive resuscitation. Appropriate use following established guidelines can be beneficial and may even be superior to packed RBCs. A fluid containing the vital properties of fresh whole blood would serve as a bridge to allow a patient to be resuscitated without initiating the''bloody cycle of death'' that is seen all too often in our current paradigm of massive resuscitation. abstract: Component therapy is useful for the majority of patients when blood requirements are minimal and there is no associated coagulopathy. Of concern are requirements for massive transfusion and resuscitation that absorb resources and create a short-fall for patients whose injuries are less severe. Additionally, the conventional massive transfusion model of packed RBCs, plasma and platelets actually further dilutes the patient compared to the blood he or she has lost and thus is not the ideal fluid for patients who require this massive transfusion of products. Fresh whole blood has three vital properties: oxygen carrying capacity, volume, and hemostatic effect. In the austere environment of combat the practice of fresh whole blood transfusion has proven beneficial to patients who are coagulopathic and require massive transfusion. Appropriate use following established guidelines can be beneficial and may even be superior to packed RBCs. A fluid containing the vital properties of fresh whole blood would serve as a bridge to allow a patient to be resuscitated without initiating the ‘bloody cycle of death’ that is seen all too often in our current paradigm of massive resuscitation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123784/ doi: 10.1007/3-540-33396-7_25 id: cord-280241-h16s6wwm author: McStay, R. title: COVID-19: looking beyond the peak. Challenges and tips for radiologists in follow-up of a novel patient cohort date: 2020-10-08 words: 4857.0 sentences: 215.0 pages: flesch: 40.0 cache: ./cache/cord-280241-h16s6wwm.txt txt: ./txt/cord-280241-h16s6wwm.txt summary: Following on from initial statements in the acute phase of the pandemic (1) (2), this update from the British Society of Thoracic Imaging group aims to provide an overview of the multisystem complications of COVID-19 with a focus on the thoracic manifestations, in particular the lung parenchymal and pulmonary vascular sequelae. The authors will also explore the British Thoracic Society (BTS) guidance on the respiratory follow-up of patients with COVID-19, including the resource implications for departments, discuss the potential use of structured reporting of follow-up imaging and outline future opportunities for longitudinal data collection and research. A perilobular pattern of organising pneumonia (32) , recognised in the acute phase of the disease, may also be present on follow-up but may dissipate on later imaging, especially if unaccompanied by signs of fibrosis (Fig. 10) . abstract: As the coronavirus pandemic evolves, the focus of radiology departments has begun to change. The acute phase of imaging a new disease entity whilst rationalising radiology services in the face of lockdown has passed. Radiologists are now becoming familiar with the complications of COVID-19, particularly the lung parenchymal and pulmonary vascular sequelae and are considering the impact follow-up imaging may have on departments already struggling with a backlog of suspended imaging in the face of reduced capacity. This review from the British Society of Thoracic Imaging explores both the thoracic and extra-thoracic complications of COVID-19, recognising the importance of a holistic approach to patient follow-up. The British Thoracic Society guidelines for respiratory follow-up of COVID-19 will be discussed, together with newly developed reporting templates, which aim to provide consistency for clinicians as well as an opportunity for longer-term data collection. url: https://api.elsevier.com/content/article/pii/S0009926020304402 doi: 10.1016/j.crad.2020.09.025 id: cord-030380-okue1kso author: McWilliams, J. Michael title: Professionalism Revealed: Rethinking Quality Improvement in the Wake of a Pandemic date: 2020-07-22 words: 5912.0 sentences: 290.0 pages: flesch: 43.0 cache: ./cache/cord-030380-okue1kso.txt txt: ./txt/cord-030380-okue1kso.txt summary: Conceptually, with informed and motivated professionals as their agents, patients effectively become discerning consumers capable of driving healthy competition in health care markets where extrinsic pressure may be needed to encourage highquality care (e.g., primary care physicians [PCPs] directing patients to the safest hospitals or surgeons selecting the best devices). (This article focuses largely on physician agency as an instructive case, but other health care professionals act as agents, too, presenting analogous issues that are no less important.) Potential refinements notwithstanding, the dissatisfying pace of quality improvement over the last 2 decades should tell us that measure-reliant approaches are unlikely to deliver on their promise." As the concept of quality is reduced to that which is measured, improvement redefined as higher scores, extrinsic judgments elevated above unseen efforts, and time for patients and colleagues hijacked by box-checking, demoralization sets in.17 , 18 Purpose is undermined as demands on physicians diverge from their values, professional identity is lost, and intrinsic motivation gives way to a self-fulfilling prophecy that physicians care only about financial incentives. abstract: The response of clinicians to the Covid-19 pandemic has been remarkable but unsurprising. As the hard work of improving health care delivery resumes, their performance should serve as a reminder that professionalism in medicine is a resource to harness and not squander. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380704/ doi: 10.1056/cat.20.0226 id: cord-308010-ix0xi5jb author: Mcloughlin, Benjamin C. title: Functional and cognitive outcomes after COVID-19 delirium date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To ascertain delirium prevalence and outcomes in COVID-19. METHODS: We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes were physical and cognitive function. RESULTS: In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. At 4 weeks, 20 (28%) had died, 26 (36%) were interviewed by telephone and 21 (30%) remained as inpatients. Physical function was substantially worse in people after delirium − 50 out of 166 points (95% CI − 83 to − 17, p = 0.01). Mean cognitive scores at follow-up were similar and delirium was not associated with mortality in this sample. CONCLUSIONS: Our findings indicate that delirium is common, yet under-recognised. Delirium is associated with functional impairments in the medium term. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s41999-020-00353-8) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s41999-020-00353-8 doi: 10.1007/s41999-020-00353-8 id: cord-258692-dch1utis author: Mead, Kenneth title: An evaluation of portable high-efficiency particulate air filtration for expedient patient isolation in epidemic and emergency response date: 2004-10-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Extraordinary incidents resulting in airborne infectious disease outbreaks could produce patient isolation requirements that exceed most hospitals' capacity. This article investigates expedient methods to establish airborne infection isolation areas using a commercially available portable filtration unit and common hardware supplies. The study was conducted within a conventional, nonisolation hospital room, and researchers evaluated several airborne isolation configurations that did not require building ventilation or structural modifications. A portable high-efficiency particulate air filtration unit and full-length plastic curtains established a “zone-within-zone” protective environment using local capture and directional airflows. The cost of constructing the expedient configurations was less than US$2,300 and required fewer than 3 person-hours to construct. A medical nebulizer aerosolized polystyrene latex microspheres to generate respirable condensation nuclei. Aerosol spectrometers sized and counted respirable particles at the source patient and health care worker positions and in areas outside the inner zone. The best-performing designs showed no measurable source migration out of the inner isolation zone and mean respirable particle counts up to 87% lower at the health care worker position(s) than those observed directly near the source patient location. Investigators conclude that with careful implementation under emergency circumstances in which engineered isolation rooms are unavailable, expedient methods can provide affordable and effective patient isolation while reducing exposure risks and potential disease transmission to health care workers, other patients, and visitors. url: https://www.ncbi.nlm.nih.gov/pubmed/15573040/ doi: 10.1016/j.annemergmed.2004.07.451 id: cord-316376-76beuk0c author: Medeiros, Augusto Kreling title: Higher frequency of hepatic steatosis at CT among COVID-19-positive patients date: 2020-07-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Recent studies have demonstrated that obesity is significantly associated with increased disease severity, hospitalizations and mortality in COVID-19, with a potential role in the pathogenesis and prevalence in the new pandemic. The association with hepatic steatosis, however, a condition closely related to obesity within the spectrum of systemic metabolic dysfunctions, remains to be elucidated. We aimed to evaluate the frequency of hepatic steatosis as incidentally detected in chest CT examinations of COVID-19 positive patients in comparison to non-infected controls. METHODS: A retrospective study was performed with 316 patients (204 RT-PCR positive; 112 RT-PCR negative and chest CT negative). Steatosis was measured with placement of a single ROI in the right lobe of the liver (segments VI-VII) and defined as a liver attenuation value ≤ 40 HU. RESULTS: The frequency of hepatic steatosis was higher in the RT-PCR positive group in comparison to controls (31.9% vs. 7.1%, p < 0.001). Logistic linear regression analysis showed a 4.7 times odds of steatosis in the COVID-19 positive group as compared to controls after adjusting for age and sex (OR 4.698; 95% IC 2.12–10.41, p < 0.001). CONCLUSION: A significantly higher prevalence of steatosis was found among COVID-19 positive individuals. These findings are in accordance with other recent studies linking obesity and COVID-19 infection, as there is an intricate relationship between liver steatosis, metabolic syndrome and obesity. Further studies are required to confirm if such association remains after accounting for multiple variables, as well as possible relationships with disease severity and worst clinical outcomes. url: https://doi.org/10.1007/s00261-020-02648-7 doi: 10.1007/s00261-020-02648-7 id: cord-034435-yp0gfl47 author: Medetalibeyoglu, A. title: Older Adults Hospitalized with Covid-19: Clinical Characteristics and Early Outcomes from a Single Center in Istanbul, Turkey date: 2020-10-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Older adults have been continuously reported to be at higher risk for adverse outcomes of Covid-19. We aimed to describe clinical characteristics and early outcomes of the older Covid-19 patients hospitalized in our center comparatively with the younger patients, and also to analyze the triage factors that were related to the in-hospital mortality of older adults. DESIGN: Retrospective; observational study. SETTING: Istanbul Faculty of Medicine hospital, Turkey. PARTICIPANTS: 362 hospitalized patients with laboratory-confirmed Covid-19 from March 11 to May 11, 2020. MEASUREMENTS: The demographic information; associated comorbidities; presenting clinical, laboratory, radiological characteristics on admission and outcomes from the electronic medical records were analyzed comparatively between the younger (<65 years) and older (≥65 years) adults. Factors associated with in-hospital mortality of the older adults were analyzed by multivariate regression analyses. RESULTS: The median age was 56 years (interquartile range [IQR], 46–67), and 224 (61.9%) were male. There were 104 (28.7%) patients ≥65 years of age. More than half of the patients (58%) had one or more chronic comorbidity. The three most common presenting symptoms in the older patients were fatigue/myalgia (89.4%), dry cough (72.1%), and fever (63.5%). Cough and fever were significantly less prevalent in older adults compared to younger patients (p=0.001 and 0.008, respectively). Clinically severe pneumonia was present in 31.5% of the study population being more common in older adults (49% vs. 24.4%) (p<0.001). The laboratory parameters that were significantly different between the older and younger adults were as follows: the older patients had significantly higher CRP, D-dimer, TnT, pro-BNP, procalcitonin levels, higher prevalence of lymphopenia, neutrophilia, increased creatinine, and lower hemoglobin, ALT, albumin level (p<0.05). In the radiological evaluation, more than half of the patients (54.6%) had moderate-severe pneumonia, which was more prevalent in older patients (66% vs. 50%) (p=0.006). The adverse outcomes were significantly more prevalent in older adults compared to the younger patients (ICU admission, 28.8% vs. 8.9%; mortality, 23.1% vs. 4.3%, p<0.001). Among the triage evaluation parameters, the only factor associated with higher mortality was the presence of clinically severe pneumonia on admission (Odds Ratio=12.3, 95% confidence interval=2.7–55.5, p=0.001). CONCLUSION: Older patients presented with more prevalent chronic comorbidities, less prevalent symptomatology but more severe respiratory signs and laboratory abnormalities than the younger patients. Among the triage assessment factors, the clinical evaluation of pulmonary involvement came in front to help clinicians to stratify the patients for mortality risk. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597420/ doi: 10.1007/s12603-020-1499-9 id: cord-023873-fidpskcs author: Meersseman, Wouter title: Invasive Aspergillosis in the Intensive Care Unit: Beyond the Typical Haematological Patient date: 2009-05-04 words: 4137.0 sentences: 208.0 pages: flesch: 39.0 cache: ./cache/cord-023873-fidpskcs.txt txt: ./txt/cord-023873-fidpskcs.txt summary: Finally, to date, the diagnostic utility of recently available non-culture based microbiological tools, including the detection of fungal antigens and the detection of Aspergillus-specific DNA through polymerase chain reaction (PCR) techniques, has not been properly validated in the non-haematology ICU population. In addition, typical ICU patients such as those with chronic obstructive pulmonary disease (COPD) or liver disorders were not considered amongst hosts at high risk for IA in the recently updated EORTC/MSG guidelines [2] . In a recent study published by our group [10] , patients with fever new lung infiltrates were screened for IA using galactomannan testing in bronchoalveolar (BAL) fluid. The concept that increasing fungal burden due to specific ICU treatments for other diseases than IA (e.g. steroids for septic shock) parallels the progression from subclinical to clinical aspergillosis, needs to be explored with more sensitive markers (e.g. PCR). Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease abstract: Data about incidence of invasive aspergillosis in intensive care units (ICU) are scarce and variable. Incidences ranging from 2 to 24% have been reported, which might reflect different autopsy policies amongst centres. Recent studies have shown that many patients with invasive aspergillosis do not have a haematological diagnosis. Instead, conditions such as chronic obstructive pulmonary disease and liver failure became recognized as important risk factors. The diagnosis remains difficult in these patients, since diagnostic tests have not been widely validated outside the haematological boundaries. Mechanical ventilation precludes the interpretation of clinical signs and radiological diagnosis is clouded by underlying lung pathology. Respiratory cultures lack sensitivity and specificity. At the moment, diagnosis is best made by testing for galactomannan in bronchoalveolar fluid samples (sensitivity and specificity of > 87%). Testing galactomannan in sera has limited sensitivity for the non-neutropenic. Modern diagnostic tests such as PCR and beta-glucan have never been validated in an ICU population. Due mostly to major delays in the diagnosis, mortality exceeds 50%. Although our therapeutic armamentarium against invasive aspergillosis has improved in recent years, data concerning safety and efficacy of new antifungal agents in the ICU setting are lacking. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176220/ doi: 10.1007/978-90-481-2408-4_29 id: cord-340660-ocvy1ge2 author: Mehmood, Maham A title: Methicillin-Resistant Staphylococcus Aureus: A Very Rare Cause of Meningitis date: 2020-09-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is mostly implicated in soft tissue and skin infections. Cases with meningitis caused by CA-MRSA are rare. High index of suspicion should be kept for physicians as bacterial meningitis is a medical emergency and if untreated, has a high mortality rate. Urgent steps need to be taken to determine the cause and implement therapy. Here, we reported a case of a 58-year-old female with MRSA bacteremia and meningitis as confirmed by positive blood cultures and cerebrospinal fluid analysis; successfully managed with vancomycin and rifampin. url: https://www.ncbi.nlm.nih.gov/pubmed/33062493/ doi: 10.7759/cureus.10370 id: cord-354337-a70avg2x author: Mehraeen, Esmaeil title: A systematic review of ECG findings in patients with COVID-19 date: 2020-11-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Since the epidemic of COVID-19 attractedthe attention, reports were surrounding electrocardiographic changes in the infected individuals. We aimed at pinpointing different observed ECG findings and discussing their clinical significance. METHODS: We conducted a systematic search in PubMed, Embase, and Scopus databases. We included eligible original papers, reports, letters to the editors, and case reports published from December 2019 to May 10, 2020. RESULTS: The team identified 20 articles related to this topic. We divided them into articles discussing drug-induced and non-drug-induced changes. Studies reported an increased risk of QTc interval prolongations influenced by different therapies based on chloroquine, hydroxychloroquine, and azithromycin. Although these medications increased risks of severe QTc prolongations, they induced no arrhythmia-related deaths. In the non-drug-induced group, ST-T abnormalities, notably ST elevation, accounted for the most observed ECG finding in the patients with COVID-19, but their relation with myocardial injuries was under dispute. CONCLUSION: This systematic review suggests that identifying ECG patterns that might be related to COVID-19 is vital. Provided that physicians do not recognize these patterns, they might erroneously risk the lives of their patients. Furthermore, important drug-induced ECG changes provide awareness to the health-care workers on the risks of possible therapies. url: https://www.sciencedirect.com/science/article/pii/S001948322030273X?v=s5 doi: 10.1016/j.ihj.2020.11.007 id: cord-277811-j58qvyum author: Mehrani, Hossein title: Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis date: 2011-01-07 words: 4086.0 sentences: 226.0 pages: flesch: 51.0 cache: ./cache/cord-277811-j58qvyum.txt txt: ./txt/cord-277811-j58qvyum.txt summary: title: Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis Haptoglobin α1 chain isoforms (spots 21, 22 and 23) were only detected in the plasma of the severe lung diseases patients but were not detectable in healthy controls ( Figure 2B and 2C). In this study we present plasma proteome analysis of SM exposed patients compared to the healthy controls. In our recent study of BAL fluid proteomics patterns in SM exposed patients we also found that haptoglobin isoforms were significantly elevated in moderate and severe lung disease patients compared to mild and healthy controls [13] . In conclusion, this study complements our previous BAL fluid proteome analysis of patients exposed to SM gas which resulted in identification of number of differentially expressed proteins. Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis abstract: INTRODUCTION: Sulfur mustard "bis (2-chlroethyl) sulphide" (SM) is a chemical warfare agent that remains a threat to human health. The aim of this study was to identify protein expression signature or biomarkers that reflect chronic lung damages induced by SM exposure. METHODS: Prior to analysis, plasma was fractionated using ethanol precipitation. Using two dimensional SDS-PAGE; fractionated protein profiles of 20 healthy and 20 exposed patients with lung diseases were established. Selected protein spots were successfully identified with MALDI TOF MS/MS. RESULTS: The results show that α1 haptoglobin isoforms were detected in plasma of the all lung disease patients but none of the healthy controls. Amyloid A1 isoforms was also detected in plasma of the lung disease patients but none of the healthy controls. Moreover, low molecular weight proteins were enriched in ethanol supernatant compared to ethanol precipitate. CONCLUSION: Our present results and previous studies suggest that ongoing tissue remodeling is involved in SM exposed lung damage patients. These finding might improve patient care and suitable therapies. url: https://www.ncbi.nlm.nih.gov/pubmed/21906349/ doi: 10.1186/1559-0275-8-2 id: cord-030254-eevqclsy author: Mehta, Chitra title: Management of Coronavirus 2019 date: 2020-04-24 words: 4032.0 sentences: 287.0 pages: flesch: 56.0 cache: ./cache/cord-030254-eevqclsy.txt txt: ./txt/cord-030254-eevqclsy.txt summary: A suspected case has been defined as a patient with acute onset respiratory infection with fever, cough, sore throat, and an epidemiological link in the form of a history of travel 14 days prior to the onset of symptoms to countries afflicted with COVID-19, or a close contact with a confirmed or probable case of COVID-19 14 days prior to symptom onset, or some acute respiratory infection requiring hospitalization with no other etiology fully explaining the clinical presentation, as per WHO guidelines. • In patients with severe COVID-19 infection requiring supplemental oxygen, lopinavir/ritonavir combination plus hydroxychloroquine plus favipiravir 1,600 mg (eight tablets) twice daily as a loading dose followed by 600 mg (three tablets) every 8 hours for 14 days is being used. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical management of severe acute respiratory infection when COVID-19 disease is suspected. abstract: Coronavirus 2019 (COVID-19) disease is the most recent global public health problem. It is caused by SARS-CoV-2 (severe acute respiratory syndrome related coronavirus 2), which is a RNA virus with a high mutation rate, belonging to the genus Coronavirus . The objective of this communication is to provide an initial understanding regarding pathophysiology, clinical manifestations, management, and prevention of this devastating disease. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416204/ doi: 10.1055/s-0040-1710401 id: cord-324809-16zvqizl author: Mehta, Neil title: Surveillance and Monitoring of Hepatocellular Carcinoma During the COVID-19 Pandemic date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The Coronavirus disease 2019 (COVID-19) pandemic is expected to have a long-lasting impact on the approach to care for patients at risk for and with hepatocellular carcinoma (HCC) due to the risks from potential exposure and resource reallocation. The goal of this document is to provide recommendations on HCC surveillance and monitoring, including strategies to limit unnecessary exposure while continuing to provide high-quality care for patients. Publications and guidelines pertaining to the management of HCC during COVID-19 were reviewed for recommendations related to surveillance and monitoring practices, and any available guidance was referenced to support the authors’ recommendations when applicable. Existing HCC risk stratification models should be utilized to prioritize imaging resources to those patients at highest risk of incident HCC and recurrence following therapy though surveillance can likely continue as before in settings where COVID-19 prevalence is low and adequate protections are in place. Waitlisted patients who will benefit from urgent LT should be prioritized for surveillance whereas it would be reasonable to extend surveillance interval by a short period in HCC patients with lower risk tumor features and those more than 2 years since their last treatment. For patients eligible for systemic therapy, the treatment regimen should be dictated by the risk of COVID-19 associated with route of administration, monitoring and treatment of adverse events, within the context of relative treatment efficacy. url: https://www.sciencedirect.com/science/article/pii/S1542356520309381?v=s5 doi: 10.1016/j.cgh.2020.06.072 id: cord-310779-4puiao40 author: Mehta, Pooja title: Telehealth and Nutrition Support During the Covid-19 Pandemic date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32792328/ doi: 10.1016/j.jand.2020.07.013 id: cord-326468-xcy7v1tf author: Mehta, R. M. title: A shorter symptom-onset to remdesivir treatment (SORT) interval is associated with a lower mortality in moderate-to-severe COVID-19: A real-world analysis date: 2020-11-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Remdesivir is the current recommended anti-viral treatment in moderate-to-severe COVID-19. However, data on several aspects of its use such as impact of timing of therapy, efficacy, and safety in this severity category are limited. The current study aimed to evaluate the impact of timing of remdesivir initiation (symptom-onset to remdesivir treatment [SORT] interval) on in-hospital all-cause mortality in patients with moderate-to-severe COVID-19. Methods: This retrospective study was conducted between June 25, 2020 and October 3, 2020, at a tertiary care dedicated COVID center in India. Consecutive patients with moderate-to-severe COVID-19 (moderate: SpO2 <94%; severe: SpO2 <90%) were included. Data were collected from the health records of the hospital. Remdesivir was administered along with other standard medications as per protocol. The main outcome was the impact of SORT interval on in-hospital all-cause mortality. Subgroups were formed based on SORT interval. Other measures analyzed included overall in-hospital mortality, length of hospital stay, and safety. Results: Of 350 patients treated with remdesivir, 346 were included for the final analysis (males: 270 [78.0%]; median [range] age: 60 [24-94] years). Overall, 243 (70.2%) patients had [≥]1 comorbidity; 109 (31.5%) patients had moderate disease, 237 (68.5%) had severe disease, and 50 (14.5%) patients required mechanical ventilation. Of the 346 patients, 76 (22.0%) patients died (moderate: 3 [2.8%], severe: 73 [30.8%]). In the subset of mechanically ventilated patients, 43 (86.0%) died. All-cause mortality was significantly lower in patients with SORT interval [≤]9 days (n = 260) compared with those with SORT interval >9 days (n = 86; 18.1% vs 33.7%; P = .004). The odds of death were significantly lower in patients with SORT interval [≤]9 days vs >9 days (odds ratio = 0.44; 95% CI, 0.25-0.76; P = .004). Adverse events (transaminitis [≥]5 times upper limit of normal or estimated glomerular filtration rate <30ml/min) leading to drug discontinuation were seen in 4 (1.1%) patients. Conclusion: In this large series of moderate-to-severe COVID-19, initiation of remdesivir [≤]9 days from symptom-onset was associated with a significant mortality benefit. These findings indicate a treatment window and reinforce the need for earlier remdesivir initiation in moderate-to-severe COVID-19 infection. url: https://doi.org/10.1101/2020.11.05.20226373 doi: 10.1101/2020.11.05.20226373 id: cord-260525-bohv78hi author: Mei, Yang title: Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza date: 2020-07-31 words: 4168.0 sentences: 228.0 pages: flesch: 47.0 cache: ./cache/cord-260525-bohv78hi.txt txt: ./txt/cord-260525-bohv78hi.txt summary: We compiled laboratory results from the first 14 days of the hospitalized patients using parameters that are most significantly different between COVID-19 and influenza and hierarchically clustered COVID-19 patients. Patients in the highest risk cluster had leukocytosis including neutrophilia and monocytosis, severe anemia, increased red blood cell distribution width, higher BUN, creatinine, D-dimer, alkaline phosphatase, bilirubin, and troponin. Overall, our study reveals significant differences in the laboratory parameters between the hospitalized COVID-19 and influenza patients. Compared to influenza patients, the most significant differences over the course of 14 days of hospitalization in COVID-19 patients were worsening anemia, worsening leukocytosis, and an increase in D-dimer, BUN, and ALT. Instead of comparing clinical endpoints to evaluate risks as performed in most of the published studies, we stratified the hospitalized COVID-19 patients through clustering of their laboratory results that were most significantly different from influenza patients (i.e. complete blood count, D-dimer, BUN, and ALT) during the first 14 days of hospitalization. abstract: BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 overlaps with the flu season. METHODS: We compared clinical and laboratory results from 719 influenza and 973 COVID-19 patients from January to April 2020. We compiled laboratory results from the first 14 days of the hospitalized patients using parameters that are most significantly different between COVID-19 and influenza and hierarchically clustered COVID-19 patients. FINDINGS: Compared to influenza, patients with COVID-19 exhibited a continued increase in white blood cell count, rapid decline of hemoglobin, more rapid increase in blood urea nitrogen (BUN) and D-dimer, and higher level of alanine transaminase, C-reactive protein, ferritin, and fibrinogen. COVID-19 patients were sub-classified into 5 clusters through a hierarchical clustering analysis. Medical records were reviewed and patients were risk stratified based on the clinical outcomes. The cluster with the highest risk showed 27·8% fatality, 94% ICU admission, 94% intubation, and 28% discharge rates compared to 0%, 38%, 22%, and 88% in the lowest risk cluster, respectively. Patients in the highest risk cluster had leukocytosis including neutrophilia and monocytosis, severe anemia, increased red blood cell distribution width, higher BUN, creatinine, D-dimer, alkaline phosphatase, bilirubin, and troponin. INTERPRETATION: There are significant differences in the clinical and laboratory courses between COVID-19 and influenza. Risk stratification in hospitalized COVID-19 patients using laboratory data could be useful to predict clinical outcomes and pathophysiology of these patients. FUNDING: National Institute of Diabetes and Digestive and Kidney Disease, Department of Defense, and National Heart, Lung, and Blood Institute. url: https://www.ncbi.nlm.nih.gov/pubmed/33089115/ doi: 10.1016/j.eclinm.2020.100475 id: cord-306997-84pjfawk author: Melazzini, Federica title: Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy date: 2020-11-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score > 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p < 0.0001) or lactate dehydrogenase (LDH) (p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p < 0.0001). Platelet-to-lymphocyte ratio significantly correlated with CRP (p < 0.0001). The majority of VTE patients was male and younger compared to non-VTE patients (p = 0.002 and p = 0.005, respectively). No significant difference was found in d-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11739-020-02550-6) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s11739-020-02550-6 doi: 10.1007/s11739-020-02550-6 id: cord-338135-zwo7e7gy author: Melis, Daniele title: Clinical efficacy, speed of improvement and safety of apremilast for the treatment of adult Psoriasis during COVID‐19 pandemic date: 2020-05-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Time to improvement is a crucial characteristic for effective treatments of chronic inflammatory conditions, such as psoriasis. Apremilast is a recently approved drug, belonging to the small molecule phosphodiesterase 4 inhibitors, whose optimal safety and efficacy profile is somewhat affected by slow activity rate in clinical trials. Real world case series are suggesting a more consistent improvement, and with this additional personal investigation on 48 patients, we signal that 58% of patients achieved PASI50, and 19% PASI75 improvement in the first 8 weeks of treatment. Results at 16‐week are remarkable, with overall 55% of patients achieving PASI 75, 21% PASI 90 and 14% PASI 100. Only 8 patients (18, 6%) had slightly improved, although satisfied with the regimen, and determined to continue. Noteworthy, our population was rather problematic in terms of comorbidities (86%), and resistance to other treatments, with only 28% naïve to systemics, including biologics. Moreover, the observation period includes the Italian outbreak of COVID‐19 epidemic, and further information on apremilast safety are provided, no one of the patients having stopped treatment. In such a critical period, the apremilast satisfactory speed of therapeutic response in a real‐world setting has further strengthens patient’s compliance to remain safely at home, which is the best strategy to limit contagion. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1111/dth.13722 doi: 10.1111/dth.13722 id: cord-284251-brn5izwo author: Melmed, Kara R. title: Risk factors for intracerebral hemorrhage in patients with COVID-19 date: 2020-09-24 words: 3640.0 sentences: 189.0 pages: flesch: 41.0 cache: ./cache/cord-284251-brn5izwo.txt txt: ./txt/cord-284251-brn5izwo.txt summary: We performed a retrospective cohort study of adult (age ≥ 18 years) patients admitted to the NYU Langone Health System (NYU Langone Medical Center, NYU Brooklyn, NYU Winthrop, or NYU Langone Orthopedic Hospital) who had both a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) test result and neuroimaging performed between March 1 and April 27, 2020. We used binary logistic regression models to estimate the odds ratios and 95% confidence intervals (OR, 95% CI) of therapeutic anticoagulation use and ICH in patients hospitalized with COVID-19 adjusting for previously identified factors associated with ICH (age, gender, ethnicity, hypertension, systolic blood pressure) and might plausibly be associated with ICH in COVID-19 patients. Binary logistic regression models were used to assess for mortality in both ICH and non-ICH patients adjusting for previously reported risk factors, age [7] and maximum hospital SOFA score, [18] as a marker for disease severity. abstract: Intracerebral hemorrhage (ICH) can be a devastating complication of coronavirus disease (COVID-19). We aimed to assess risk factors associated with ICH in this population. We performed a retrospective cohort study of adult patients admitted to NYU Langone Health system between March 1 and April 27 2020 with a positive nasopharyngeal swab polymerase chain reaction test result and presence of primary nontraumatic intracranial hemorrhage or hemorrhagic conversion of ischemic stroke on neuroimaging. Patients with intracranial procedures, malignancy, or vascular malformation were excluded. We used regression models to estimate odds ratios and 95% confidence intervals (OR, 95% CI) of the association between ICH and covariates. We also used regression models to determine association between ICH and mortality. Among 3824 patients admitted with COVID-19, 755 patients had neuroimaging and 416 patients were identified after exclusion criteria were applied. The mean (standard deviation) age was 69.3 (16.2), 35.8% were women, and 34.9% were on therapeutic anticoagulation. ICH occurred in 33 (7.9%) patients. Older age, non-Caucasian race, respiratory failure requiring mechanical ventilation, and therapeutic anticoagulation were associated with ICH on univariate analysis (p < 0.01 for each variable). In adjusted regression models, anticoagulation use was associated with a five-fold increased risk of ICH (OR 5.26, 95% CI 2.33–12.24, p < 0.001). ICH was associated with increased mortality (adjusted OR 2.6, 95 % CI 1.2–5.9). Anticoagulation use is associated with increased risk of ICH in patients with COVID-19. Further investigation is required to elucidate underlying mechanisms and prevention strategies in this population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11239-020-02288-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32968850/ doi: 10.1007/s11239-020-02288-0 id: cord-321552-lsz1onrj author: Membrilla, Javier A. title: Headache as a Cardinal Symptom of Coronavirus Disease 2019: A Cross‐Sectional Study date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To describe the semiology of pain and its associated features in patients with coronavirus disease 2019 (COVID‐19) and headache presenting to the emergency department who do not require urgent services. BACKGROUND: Headache is one of the most frequent neurological symptoms reported in case series, epidemiological studies, and meta‐analyses of COVID‐19, with a prevalence ranging from 8 to 71.1%. Studies addressing the semiology of these headaches are lacking. METHODS: We conducted a cross‐sectional study in the emergency department of a tertiary hospital. Patients classified according to the Manchester Triage System as standard and non‐urgent and those fulfilling the criteria for probable or confirmed COVID‐19 according to World Health Organization guidelines who presented with headache were included. A standardized questionnaire was used for data collection. RESULTS: Of the 145 confirmed and probable COVID‐19 patients, 99 (68.3%) reported headache. A total of 54/99 (54.5%) were classified with probable COVID‐19 and 45/99 (45.5%) with confirmed COVID‐19. The mean age (44.7 ± 11.8 vs 40.4 ± 10.7, P = .061), sex distribution (35/54 [64.8%] vs 28/45 [62.2%] female, P = .768), and headache comorbidity (19/54 [35.2%] vs 17/45 [37.8%], P = .789) were similar between the probable and confirmed COVID‐19 groups, along with other medical comorbidities and laboratory data. Patients with confirmed COVID‐19 showed a higher incidence of anosmia (21/54 [38.9%] vs 28/45 [62.2%], P = .021) and pneumonia (10/54 [18.5%] vs 18/45 [40%], P = .018), headache at onset (32/54 [59.3%] vs 39/45 [86.7%], P = .002), and hospital admission (0/54 [0%] vs 2/45 [11.1%], P = .017). In most cases, the headache appeared simultaneously with other COVID‐19 symptoms (57/99, 57.6%). It was bilateral (86/99, 86.9%), frontal or holocranial (34/99, 34.3% each) in location and intense (60/99, 60.6%, reported a visual analog scale [VAS] score ≥7). A total of 39/99 (39.4%) identified triggers, most commonly fever. The most frequent aggravating factors were physical activity (45/99, 45.5%) and coughing (43/99, 43.4%). Patients showed a propensity toward prostration (41/99, 41.4%), photophobia (29/99, 29.3%), and phonophobia (27/99, 27.3%). Partial (53/99, 53.5%) or total (26/99, 26.3%) responses to first‐step analgesics were reported. A total of 25/99 (25.3%) patients had a prior history of migraine, presenting with headache different from the usual in 23/25 (92.0%) patients. Individuals with migraine were more likely to have earlier (headache at onset of the respiratory symptoms in 24/25 [96.0%] vs 57/74 [77.0%], P = .023 [95% CI: 0.067, 0.313]), longer (>24 hours of pain in 20/25 [80%] vs 25/74 [33.8%], P < .001 [95% CI: 0.272, 0.652]), and more intense (VAS score ≥5 in 25/25 [100%] vs 63/74 [85.1%], P = .043 [95% CI: 0.057, 0.213]) headaches than patients without migraine. CONCLUSIONS: Headache is a very prevalent COVID‐19 symptom among patients presenting to the emergency room, most frequently presenting as holocranial or bifrontal moderate to severe, and pressing quality headache. Individuals with migraine tend to present with earlier, longer, and more intense headaches. url: https://doi.org/10.1111/head.13967 doi: 10.1111/head.13967 id: cord-001154-7k59ogn0 author: Memoli, Matthew J. title: The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts date: 2013-11-01 words: 3912.0 sentences: 200.0 pages: flesch: 31.0 cache: ./cache/cord-001154-7k59ogn0.txt txt: ./txt/cord-001154-7k59ogn0.txt summary: Evaluation of viral shedding, nasal and serum cytokines, clinical illness, and clinical outcomes were performed to compare severely immunocompromised individuals to nonimmunocompromised individuals with influenza infection. Immunocompromised patients with influenza had more severe disease/complications, longer viral shedding, and more antiviral resistance while demonstrating less clinical symptoms and signs on clinical assessment. Careful examination of symptoms and signs of infection, virological measurements, immunological studies, and clinical parameters were performed to investigate the natural pathogenesis of influenza in this group of severely immunocompromised hosts. The comparison of these individuals with nonimmunocompromised individuals during influenza infection demonstrated that the immunocompromised patients are at risk of more severe or complicated disease, which may be difficult to prevent with current vaccines and treat with current antivirals. abstract: Introduction. Medical advances have led to an increase in the world's population of immunosuppressed individuals. The most severely immunocompromised patients are those who have been diagnosed with a hematologic malignancy, solid organ tumor, or who have other conditions that require immunosuppressive therapies and/or solid organ or stem cell transplants. Materials and methods. Medically attended patients with a positive clinical diagnosis of influenza were recruited prospectively and clinically evaluated. Nasal washes and serum were collected. Evaluation of viral shedding, nasal and serum cytokines, clinical illness, and clinical outcomes were performed to compare severely immunocompromised individuals to nonimmunocompromised individuals with influenza infection. Results. Immunocompromised patients with influenza had more severe disease/complications, longer viral shedding, and more antiviral resistance while demonstrating less clinical symptoms and signs on clinical assessment. Conclusions. Immunocompromised patients are at risk for more severe or complicated influenza induced disease, which may be difficult to prevent with existing vaccines and antiviral treatments. Specific issues to consider when managing a severely immunocompromised host include the development of asymptomatic shedding, multi-drug resistance during prolonged antiviral therapy, and the potential high risk of pulmonary involvement. Clinical trials registration, ClinicalTrials.gov identifier NCT00533182. url: https://academic.oup.com/cid/article-pdf/58/2/214/963674/cit725.pdf doi: 10.1093/cid/cit725 id: cord-283806-a6exd6dn author: Menardi, Endrj title: Telemedicine during COVID‐19 pandemic date: 2020-05-30 words: 683.0 sentences: 31.0 pages: flesch: 40.0 cache: ./cache/cord-283806-a6exd6dn.txt txt: ./txt/cord-283806-a6exd6dn.txt summary: From 2017 the home monitoring outpatient follow‐up service has been systematically organized mainly for the peculiar geographical features (typically mountainous, vast and with few roads) of the territory served by our hospital, making difficult for patients the access to the health care facilities. From 2017 the home monitoring outpatient follow-up service has been systematically organized mainly for the peculiar geographical features (typically mountainous, vast and with few roads) of the territory served by our hospital, making difficult for patients the access to the health care facilities. We have 454 patients (373 pts -ICDs/Cardiac resynchronization therapy defibrillators (CRT-Ds), 11 pts -PMs/Cardiac resynchronization therapy pacemaker (CRT-P) and 70 pts -ILRs) followed with home monitoring systems, with automatic and periodical transmissions regarding device setting, clinical features and alarms. abstract: Since 2015 most patients implanted with cardiac devices (Implantable Cardioverter Defibrillators (ICDs), Implantable Loop Recorders (ILRs), Pacemakers (PMs)) at Santa Croce e Carle Hospital (Cuneo, Italy) are remotely followed with home monitoring systems free of charge. From 2017 the home monitoring outpatient follow‐up service has been systematically organized mainly for the peculiar geographical features (typically mountainous, vast and with few roads) of the territory served by our hospital, making difficult for patients the access to the health care facilities. url: https://doi.org/10.1002/joa3.12381 doi: 10.1002/joa3.12381 id: cord-352234-utjne1ef author: Mendlovic, Joseph title: Internal medicine patients admitted without COVID‐19 during the outbreak date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The first case of COVID‐19 in Israel was reported on February 21, 2020. Shaare Zedek (SZ), a 1000‐bed tertiary care medical centre in Jerusalem, Israel, cared for a significant number of these patients. While attention focused on COVID‐19 patients, uninfected patients were admitted to decreasing numbers of available internal medicine (IM) beds as IM departments were converted to COVID‐19 isolation wards. As a result of the increase in COVID‐19 patients, closure of IM wards, re‐assignment of staff and dynamic changes in available community placement options, we investigated the impact of the outbreak on IM patient not admitted for COVID‐19. METHODS: We reviewed IM admissions during March 15‐April 30, 2020 for patients without COVID‐19. Characteristics assessed included number of admissions, age, length of stay, mortality rate, number of discharges, number discharged home and functional status of the patients. Data were compared with the previous 3 years (2017‐2019) during the same time period. RESULTS: During March 15‐April 30, 2020 there were 409 patients admitted to IM compared with a mean of 557 over the previous 3 years. Fewer patients were admitted to the ED and the IM wards during the outbreak. There was no significant difference between the two groups with regards to gender, in‐hospital mortality rate, number discharged, number discharged home and patient functional level. Patients admitted during the outbreak to IM were younger (74.85 vs 76.86 years) and had a mean shorter hospital length of stay (5.12 vs 7.63 days) compared with the previous 3 years. CONCLUSION: While the characteristics of patients admitted to IM during the outbreak were similar, hospital length of stay was significantly shorter. Internal management processes, as well as patient preferences may have contributed to this observation. An infectious disease outbreak may have a significant effect on uninfected admitted patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32738812/ doi: 10.1111/ijcp.13630 id: cord-315598-qwh72inx author: Mendoza, Jose Luis Accini title: ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19 date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Antecedentes y objetivos: La enfermedad por coronavirus de 2019 (COVID-19) es una enfermedad ocasionada por el nuevo coronavirus del síndrome respiratorio agudo grave (SARS-CoV-2). Se identificó por primera vez en diciembre de 2019 en la ciudad de Wuhan, en los meses siguientes se expandió rápidamente a todos los continentes y la Organización Mundial de la Salud (OMS), la reconoció como una pandemia global el 11 de marzo de 2020. La mayoría de los individuos son asintomáticos pero una baja proporción ingresan a cuidados intensivos con una alta morbilidad y mortalidad. Este consenso tiene como objetivo actualizar la declaratoria inicial emitida por la Asociación Colombiana de Medicina Crítica (AMCI) para el manejo del paciente críticamente enfermo con COVID-19 dentro de las áreas críticas de las instituciones de salud. Métodos: Este estudio utilizó dos técnicas de consenso formal para construir las recomendaciones finales: Delphi modificada y grupos nominales. Se construyeron preguntas por la estrategia PICO. 10 grupos nominales desarrollaron recomendaciones para cada unidad temática. El producto del consenso fue evaluado y calificado en una ronda Delphi y se discutió de forma virtual por los relatores de cada núcleo y los representantes de sociedades médicas científicas afines al manejo del paciente con COID-19. Resultados: 80 expertos nacionales participaron en la actualización del consenso AMCI, especialistas en Medicina Critica y Cuidados Intensivos, Nefrología, Neurología, Neumología, bioeticistas, Medicina interna, Anestesia, Cirugía General, Cirugía de cabeza y cuello, Cuidados Paliativos, Enfermeras Especialistas en Medicina crítica, Terapeutas respiratorias especialistas en medicina crítica y Fisioterapia, con experiencia clínica en la atención del paciente críticamente enfermo. La declaratoria emite recomendaciones en los ámbitos más relevantes para la atención en salud de los casos de COVID-19 al interior de las unidades de cuidados intensivos en el contexto nacional de Colombia. Conclusiones: un grupo significativo multidisciplinario de profesionales expertos en medicina crítica emiten mediante técnicas de consenso formal recomendaciones sobre la mejor práctica para la atención del paciente críticamente enfermo con COVID-19. Las recomendaciones deben ser adaptadas a las condiciones específicas, administrativas y estructurales de las distintas unidades de cuidados intensivos del país. Background and objectives: The 2019 coronavirus disease (COVID-19) is caused by the new severe acute respiratory syndrome coronavirus (SARS-CoV-2). It was first identified in December 2019 in Wuhan, China. In the following months it spread quickly to all continents and was recognised as a global pandemic by the World Health Organization (WHO) on March 11th, 2020. Most cases of infection remain asymptomatic, while a low proportion require intensive care, experiencing high morbidity and mortality. This consensus aims to update the initial statement issued by the Colombian Association of Critical Medicine (AMCI) for the management of the critically ill patient with COVID-19 within the critical areas of health institutions. Methods: This study used two formal consensus techniques to construct the final recommendations: modified Delphi and nominal groups. Questions were constructed using the PICO strategy. Recommendations for each thematic unit were developed by 10 nominal groups. The consensus product was evaluated and qualified in a Delphi round, and was discussed virtually by the speaker of each nucleus, as well as the representatives of scientific medical societies related to the management of the patient with COVID-19. Results: A total of 80 national experts participated in the update of the AMCI consensus, all specialists in Critical and Intensive Care Medicine, Nephrologists, Neurologists, Chest physician, bioethicists, Internal medicine specialists, Anaesthetists, General Surgeons, head and neck surgery, palliative care, Nurses Specialised in Critical Medicine, Respiratory therapists specialised in critical medicine and Physiotherapy, with clinical experience in the care of critically ill patients. This update issues recommendations in the most relevant areas for health care of COVID-19 patients within the intensive care units, contextualised for Colombia. Conclusions: A significant multidisciplinary group of professionals, who are experts in critical medicine, reviewed and issued recommendations on best practice for the care of critically ill patients with COVID-19 through formal consensus techniques. Recommendations must be adapted to the specific, administrative, and structural conditions of the different intensive care units in the country. url: https://www.sciencedirect.com/science/article/pii/S0122726220300859?v=s5 doi: 10.1016/j.acci.2020.09.004 id: cord-296182-hhswage4 author: Meng, Lingzhong title: Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience date: 2020-04-08 words: 6532.0 sentences: 364.0 pages: flesch: 44.0 cache: ./cache/cord-296182-hhswage4.txt txt: ./txt/cord-296182-hhswage4.txt summary: Healthcare providers, who are tasked with taking care of critically ill patients, need to perform the best practices of intubation and ventilation tailored explicitly to the victims of this sweeping COVID-19 outbreak and, at the same time, adhere to strict self-protection precautions. The Chinese Society of Anesthesiology Task Force on Airway Management released a fast-track publication with the recommendation to proceed with endotracheal intubation for patients showing no improvement in respiratory distress, tachypnea (respiratory rate greater than 30 per minute), and poor oxygenation (Pao 2 to Fio 2 ratio less than 150 mmHg) after 2-h highflow oxygen therapy or noninvasive ventilation. Although the aerosol-generating potential of noninvasive ventilation is a potential concern to some providers, 19 the bilevel positive airway pressure machine is widely used amid this outbreak for patients with acute hypoxemic respiratory failure in Wuhan and the rest of China. abstract: The COVID-19 outbreak has led to 80,409 diagnosed cases and 3,012 deaths in mainland China based on the data released on March 4, 2020. Approximately 3.2% of patients with COVID-19 required intubation and invasive ventilation at some point in the disease course. Providing best practices regarding intubation and ventilation for an overwhelming number of patients with COVID-19 amid an enhanced risk of cross-infection is a daunting undertaking. The authors presented the experience of caring for the critically ill patients with COVID-19 in Wuhan. It is extremely important to follow strict self-protection precautions. Timely, but not premature, intubation is crucial to counter a progressively enlarging oxygen debt despite high-flow oxygen therapy and bilevel positive airway pressure ventilation. Thorough preparation, satisfactory preoxygenation, modified rapid sequence induction, and rapid intubation using a video laryngoscope are widely used intubation strategies in Wuhan. Lung-protective ventilation, prone position ventilation, and adequate sedation and analgesia are essential components of ventilation management. url: https://doi.org/10.1097/aln.0000000000003296 doi: 10.1097/aln.0000000000003296 id: cord-016973-s32jp0ej author: Menon, Nithya title: Respiratory Diseases of Pregnancy date: 2016-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Respiratory complaints in the gravid patient are often difficult to identify as a disease state, expected physiologic changes of pregnancy or both. Understanding the underlying pulmonary physiologic changes that come with pregnancy as well as those conditions which are unique to the pregnant patient will help arrive at the correct diagnosis and management. Recognizing that the gravid patient has other physiologic changes that contribute to decreased respiratory reserve, increased risk of aspiration, infection, and difficult airway can help in managing these patients acutely. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121415/ doi: 10.1007/978-3-319-43341-7_89 id: cord-316117-o29773cz author: Menzella, Francesco title: Pharmacologicaltreatment of COVID-19: lights and shadows date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: At the end of December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavirus 2, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China and then the entire world, forcing the World Health Organization to make the assessment that the coronavirus disease (COVID-19) can be characterized as a pandemic, the first ever caused by a coronavirus. To date, clinical evidence and guidelines based on reliable data and randomized clinical trials for the treatment of COVID-19 are lacking. In the absence of definitive management protocols, many treatments for COVID-19 are currently being evaluated and tested worldwide. Some of these options were soon abandoned due to ineffectiveness, while others showed promising results. The basic treatments are mainly represented by antiviral drugs, even if the evidence is not satisfactory. Among the antivirals, the most promising appears to be remdesivir. Corticosteroids and tocilizumab seem to guarantee positive results in selected patients so far, although the timing of starting therapy and the most appropriate therapeutic schemes remain to be clarified. Efficacy of the other drugs is still uncertain, and they are currently used as a cocktail of treatments in the absence of definitive guidelines. What will represent the real solution to the enormous problem taking place worldwide is the identification of a safe and effective vaccine, for which enormous efforts and investments are underway. url: https://doi.org/10.7573/dic.2020-4-6 doi: 10.7573/dic.2020-4-6 id: cord-308968-m4pzsfkd author: Mercadante, Amanda R. title: Choosing Evolution over Extinction: Integrating Direct Patient Care Services and Value-Based Payment Models into the Community-Based Pharmacy Setting date: 2020-07-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The American healthcare payment model introduced Pharmacy Benefit Managers (PBMs) into a position of power that currently puts into question the state of the pharmacy profession, especially in the community field. Reimbursement plans had been designed to benefit all stakeholders and save patients money but have only been shown to increase costs for these involved parties. There exist unresolved gaps in care as a result of the healthcare structure and underutilized skills of trained pharmacists who do not have the federal means to provide clinical services. Four collaborative payment models have been proposed, offering methods to quell the monetary problems that exist and are predicted to continue with the closure of community pharmacies and sustained influence of PBMs. These models may additionally allow the expansion of pharmacy career paths and improve healthcare benefits for patients. With a reflective perspective on the healthcare structure and knowledge of positive impacts with the inclusion of pharmacists, solutions to payment challenges could present a progressive approach to an outdated system. The impact of the COVID-19 pandemic highlights a dependency on pharmacists and community settings. This outlook on pharmacists may persist and an established expansion of services could prove beneficial to all healthcare stakeholders. url: https://www.ncbi.nlm.nih.gov/pubmed/32722217/ doi: 10.3390/pharmacy8030128 id: cord-281298-qheq9lc8 author: Merks, Piotr title: The legal extension of the role of pharmacists in light of the COVID-19 global pandemic date: 2020-06-12 words: 2154.0 sentences: 149.0 pages: flesch: 48.0 cache: ./cache/cord-281298-qheq9lc8.txt txt: ./txt/cord-281298-qheq9lc8.txt summary: Some of the novel legal extensions aimed at aiding overloaded healthcare systems are as follows: authorisation to prepare hand and surface disinfectants, eligibility to renew chronic treatment prescriptions, as well as filling pro auctore and pro familia prescriptions by pharmacists, performing COVID-19, influenza, and Group A Streptococcus screening tests, and vaccine administration. The important role of pharmacies, which form an integral part of 43 the healthcare system, should be emphasised in the daily delivery of medicines, therapeutics, vaccines, and key health services to the public. The role of pharmacies in a crisis, such as the current pandemic, is of crucial importance because they are often the first and the last point of contact with the health care system for 48 patients who need reliable information and advice. [2] [3] [4] Pharmacists play an important role in patient care during a pandemic both in 51 community pharmacies 5, 6 and in the hospital setting. abstract: BACKGROUND: The COVID-19 epidemic has affected every area of life. The greatest challenge has been to adapt the functioning of the health service to prevent the spread of the epidemic and to help infected patients. This has required the involvement of not only doctors and nurses, but also pharmacists. In the face of this pandemic, governments in many countries have granted pharmacists greater authority. OBJECTIVES: The purpose of this paper is to review the legal extension of the role of pharmacists in light of the COVID-19 pandemic. The review considers recent changes in European countries, Canada, and the United States. METHODS: A literature review was performed to summarise knowledge about the extension of the role of pharmacists during the pandemic period. Key articles were retrieved mainly from PubMed and Google Scholar, using the terms “COVID‐19”, “2019‐nCoV”, “coronavirus”, and “pandemic” in combination with “pharmacist” as keywords for our search. We included scientific publications from February 1, 2019 to May 15, 2020. RESULTS: Pharmacists have been given numerous opportunities so that they can actively join in the fight against the virus. Some of the novel legal extensions aimed at aiding overloaded healthcare systems are as follows: authorisation to prepare hand and surface disinfectants, eligibility to renew chronic treatment prescriptions, as well as filling pro auctore and pro familia prescriptions by pharmacists, performing COVID-19, influenza, and Group A Streptococcus screening tests, and vaccine administration. Moreover, many countries have facilitated Internet services, such as virtual medical consultations, e-prescriptions, and home drug delivery – to promote social distancing among patients. To mitigate drug shortages, the following strategies have been implemented: alternative sourcing, strength, generic, or therapeutic substitution, and preparing compounded formulations at the pharmacy. CONCLUSIONS: Novel legal extensions have allowed exploitation of the full potential ofpharmacists worldwide, aiding the limited resources of overloaded healthcare systems. url: https://www.sciencedirect.com/science/article/pii/S1551741120306628?v=s5 doi: 10.1016/j.sapharm.2020.05.033 id: cord-027259-f4sgobcz author: Metsker, Oleg title: Stroke ICU Patient Mortality Day Prediction date: 2020-05-23 words: 5328.0 sentences: 204.0 pages: flesch: 42.0 cache: ./cache/cord-027259-f4sgobcz.txt txt: ./txt/cord-027259-f4sgobcz.txt summary: On the basis of the analysis of 12 modern prognostic models from 10 countries we can identify some of the most stable (main) predictors for the causes of intra-hospital mortality: age [16, [20] [21] [22] [23] [24] ; type of stroke [25] ; lesion location [25] ; level of consciousness [11, 20, 23, 25, 26] upon admission; NIHSS stroke severity [10, 21, 22, 24] ; comorbidity [22, 27] , Charlson comorbidity index [23] , Atrial fibrillation [11, 22] , case history Transitor ischemic attack (TIA) [31]; hospital complications (high intracranial pressure) [16] , pneumonia, seizures, anxiety/depression, infections, limb pains and constipation [22, 27] . Early mortality in each subgroup was associated with a number of demographic, clinical, and instrumental-laboratory characteristics based on the interpretation of the results of calculating the significance of predictors of binary classification models by machine learning methods from the Scikit-Learn library 2 . abstract: This article presents a study on development of methods for analysis of data reflecting the process of treatment of stroke inpatients to predict clinical outcomes at the emergency care unit. The aim of this work is to develop models for the creation of validated risk scales for early intravenous stroke with minimum number of parameters with maximum prognostic accuracy and possibility to calculate the time of “expected intravenous stroke mortality”. The study of experience in the development and use of medical information systems allows us to state the insufficient ability of existing models for adequate data analysis, weak formalization and lack of system approach in the collection of diagnostic data, insufficient personalization of diagnostic data on the factors determining early intravenous stroke mortality. In our study we divided patients into 3 subgroups according to the time of death - up to 1 day, 1 to 3 days, and 4 to 10 days. Early mortality in each subgroup was associated with a number of demographic, clinical, and instrumental-laboratory characteristics based on the interpretation of the results of calculating the significance of predictors of binary classification models by machine learning methods from the Scikit-Learn library. The target classes in training were “mortality rate of 1 day”, “mortality rate of 1–3 days”, “mortality rate from 4 days”. AUC ROC of trained models reached 91% for the method of random forest. The results of interpretation of decision trees and calculation of significance of predictors of built-in methods of random forest coincide that can prove to correctness of calculations. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303676/ doi: 10.1007/978-3-030-50423-6_29 id: cord-324601-s3rgxtg6 author: Mhimbira, F. title: Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study date: 2019-01-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Objectives To describe the prevalence of respiratory pathogens in tuberculosis (TB) patients and in their household contact controls, and to determine the clinical significance of respiratory pathogens in TB patients. Methods We studied 489 smear-positive adult TB patients and 305 household contact controls without TB with nasopharyngeal swab samples within an ongoing prospective cohort study in Dar es Salaam, Tanzania, between 2013 and 2015. We used multiplex real-time PCR to detect 16 respiratory viruses and seven bacterial pathogens from nasopharyngeal swabs. Results The median age of the study participants was 33 years; 61% (484/794) were men, and 21% (168/794) were HIV-positive. TB patients had a higher prevalence of HIV (28.6%; 140/489) than controls (9.2%; 28/305). Overall prevalence of respiratory viral pathogens was 20.4% (160/794; 95%CI 17.7–23.3%) and of bacterial pathogens 38.2% (303/794; 95%CI 34.9–41.6%). TB patients and controls did not differ in the prevalence of respiratory viruses (Odds Ratio [OR] 1.00, 95%CI 0.71–1.44), but respiratory bacteria were less frequently detected in TB patients (OR 0.70, 95%CI 0.53–0.94). TB patients with both respiratory viruses and respiratory bacteria were likely to have more severe disease (adjusted OR [aOR] 1.6, 95%CI 1.1–2.4; p 0.011). TB patients with respiratory viruses tended to have more frequent lung cavitations (aOR 1.6, 95%CI 0.93–2.7; p 0.089). Conclusions Respiratory viruses are common for both TB patients and household controls. TB patients may present with more severe TB disease, particularly when they are co-infected with both bacteria and viruses. url: https://www.ncbi.nlm.nih.gov/pubmed/29581053/ doi: 10.1016/j.cmi.2018.03.019 id: cord-343819-1uki4b3d author: Mian, Muhammad S title: Pathological Findings and Management of COVID-19 Patients: A Brief Overview of Modern-day Pandemic date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Today the world is facing one of the deadliest pandemics caused by COVID-19. This highly transmissible virus has an incubation period of 2 to 14 days. It acts by attaching to the angiotensin-converting enzyme (ACE2) with the help of glycoprotein spikes, which it uses as a receptor. Real-time polymerase chain reaction (PCR; rt-PCR) is the gold standard diagnostic test, and chest X-ray and computed tomography (CT) scan are the other main investigations. Several medications and passive immunization are in use to treat the condition. We searched using PubMed and Google Scholar using keywords such as COVID-19, coronavirus, and their combination with pathological findings, clinical features, management, and treatment to search for relevant published literature. After the removal of duplications and the selection of only published English literature from the past five years, we had a total of 31 papers to review. Most of the COVID-19 affected patients have mild pneumonia symptoms, and those with severe disease have comorbidities. Patients with COVID-19 had pathological findings, like ground-glass opacities, consolidations, pleural effusion, lymphadenopathy, and interstitial infiltration of inflammatory cells. Radiological changes show lung changes such as consolidations and opacities, and the pathological findings were infiltration of inflammatory cells and hyalinization. Patients with mild symptoms should self-quarantine, whereas those with severe acute respiratory distress syndrome (ARDS) are treated in the hospital. Medications under trial include antivirals, antibacterials, antimalarials, and passive immunization. Supportive treatment such as oxygen therapy, extracorporeal membrane oxygenation, and ventilator support can also be used. The symptoms shown by patients are very mild and self-limiting. There is no definitive treatment, although a combination of hydroxychloroquine and azithromycin have shown good results, and passive immunization also shows promising results, their safety profile is yet to be studied in detail. url: https://www.ncbi.nlm.nih.gov/pubmed/32550056/ doi: 10.7759/cureus.8136 id: cord-031558-8wysernx author: Michas, Marta title: Factors influencing the implementation and uptake of a discharge care bundle for patients with acute exacerbation of chronic obstructive pulmonary disease: a qualitative focus group study date: 2020-08-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the most common causes of mortality and morbidity in high-income countries. In addition to the high costs of initial hospitalization, COPD patients frequently return to the emergency department (ED) and are readmitted to hospital within 30 days of discharge. A COPD acute care discharge care bundle focused on optimizing care for patients with an acute exacerbation of COPD has been shown to reduce ED revisits and hospital readmissions. The aim of this study was to explore and understand factors influencing implementation and uptake of COPD discharge care bundle items in acute care facilities from the perspective of health care providers and patients. METHODS: Qualitative methodology was adopted. Nine focus groups were conducted using a semi-structured guide: seven with acute and primary/community health care providers and two with patients/family members. Focus groups were audiotaped, transcribed verbatim, and coded and analyzed using a thematic approach. RESULTS: Forty-six health care providers and 14 patients/family members participated in the focus groups. Health care providers and patients identified four factors that can challenge the implementation of COPD discharge care bundles: process of care complexities, human capacity in care settings, communication and engagement, and attitudes and perceptions towards change. Both health care providers and patients recognized process of care complexity as the most important determinant of the COPD discharge bundle uptake. Processes of care complexity include patient activities in seeking and receiving care, as well as practitioner activities in making a diagnosis and recommending or implementing treatment. Important issues linked to human capacity in care settings included time constraints, high patient volume, and limited staffing. Communication during transitions in care across settings and patient engagement were also broadly discussed. Other important issues were linked to patients’, providers’, and system attitudes towards change and level of involvement in COPD discharge bundle implementation. CONCLUSIONS: Complexities in the process of care were perceived as the most important determinant of COPD discharge bundle implementation. Early engagement of health providers and patients in the uptake of COPD discharge bundle items as well as clear communication between acute and post-acute settings can contribute positively to bundle uptake and implementation success. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477849/ doi: 10.1186/s43058-020-00017-5 id: cord-256030-5xzuilc1 author: Michel, Pierre-Antoine title: Home hemodialysis during the COVID-19 epidemic: comment on the French experience from the viewpoint of a French home hemodialysis care network date: 2020-11-11 words: 1749.0 sentences: 74.0 pages: flesch: 47.0 cache: ./cache/cord-256030-5xzuilc1.txt txt: ./txt/cord-256030-5xzuilc1.txt summary: According to the data from the French Biomedicine Agency, during the peak period of the epidemic, between March 1 and June 15, 2020, only 7 of the 423 patients on home hemodialysis in France were diagnosed with COVID-19; the incidence is similar to that observed in patients treated with peritoneal dialysis (1.8%). For instance, in the Ile de France region, one of the most affected by the pandemic, data from the Biomedicine Agency indicate that 930 out of 8,025 patients (11.5%) on in-center hemodialysis were diagnosed with COVID-19, whereas only 4 out of 109 patients on home hemodialysis developed the disease (3.6%) (p = 0.001). Furthermore, globally 52 of our 55 patients later agreed to have a SARS-CoV-2 serology test performed, which was positive in the 2 patients Therefore, within the limits of a small series, and while waiting for additional data, we would like to confirm that our experience underlines the importance of developing an efficient home hemodialysis network, able to patients in a time of epidemic. abstract: nan url: https://doi.org/10.1007/s40620-020-00893-z doi: 10.1007/s40620-020-00893-z id: cord-018601-mk66097y author: Michelakis, Evangelos D. title: Pulmonary Arterial Hypertension date: 2007 words: 26230.0 sentences: 1416.0 pages: flesch: 44.0 cache: ./cache/cord-018601-mk66097y.txt txt: ./txt/cord-018601-mk66097y.txt summary: 18 Primary PHT was defined as mean pulmonary artery (PA) pressure >25 mm Hg at rest (or >30 mm Hg with exercise) in the absence of secondary causes for PHT, a definition different from the current definition of PAH, which includes PHT due to more common diseases like collagen vascular disease, HIV infection, portal hypertension, congenital heart disease as PAH (Table 105 .2). The following tests should be obtained in all patients in whom the cause of PHT is not evident: electrocardiogram (ECG), chest radiograph, arterial blood gases, complete blood count, electrolytes and liver function tests, pulmonary function tests (PFTs), ventilation/ perfusion lung scan, serology for rheumatic diseases (e.g., fluorescent antinuclear antibody, FANA), serology for HIV, ventilation perfusion (V/Q) scan, and an echocardiogram with Doppler assessment of PA acceleration time and tricuspid regurgitation velocity as well as an echo-contrast study, to exclude shunting. abstract: The first description of the circulation of blood through the lungs has been attributed to Ibn Nafis (1210–1288).1 The concept was rediscovered by Michael Servetus, a Spanish physician during the Renaissance (1511–1553) and recorded, oddly enough, in two pages of his religious treatise, Christianismi Restitutio (1553).2 The definitive exposition of the pulmonary circulation was made by William Harvey in DeMotu Cordis (1628).3 The first observation of the pulmonary capillaries was first reported by Marcellus Malpighi (1661).4 Heart catheterization in humans, driven by a desire to obtain the perfect mixed venous specimen and measure cardiac output, was first performed in 1929 by the German urologist Forssmann,5 using a ureteral catheter to access his own right atrium. Over a decade later, Cournand and Richards at Columbia University in New York subsequently used right heart catheterization to record pulmonary artery pressure (PAP) in patients with shock and secondary forms of pulmonary hypertension (PHT). For these accomplishments, which were inspired by an interest in the pulmonary circulation and PHT related to mitral stenosis, Forssmann, Cournand, and Richards received the Nobel Prize in 1956. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123519/ doi: 10.1007/978-1-84628-715-2_108 id: cord-006544-yr4u61qv author: Miesbach, W. title: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation date: 2004-03-20 words: 3867.0 sentences: 223.0 pages: flesch: 35.0 cache: ./cache/cord-006544-yr4u61qv.txt txt: ./txt/cord-006544-yr4u61qv.txt summary: title: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation Over the preceding 3 years the patient had presented a wide spectrum of manifestations of APS, including recurrent venous and arterial thromboses, cardiac, gynecological (HELLP syndrome), neurological involvements, livedo reticularis, a mild thrombocytopenia and the most feared manifestation of the catastrophic antiphospholipid syndrome (CAPS). The antiphospholipid syndrome (APS) is one of the most common causes of acquired thrombophilia and is characterized by arterial and/or venous thrombosis, recurrent pregnancy losses, and the laboratory evidence of antibodies against phospholipids or phospholipidbinding protein cofactors [1] . Retrospective studies suggest that patients with APS have an increased risk of recurrent thromboembolism [4, 5, 6] , and for this reason it is recommended that they receive oral vitamin K antagonists, such as warfarin, in order to achieve an international normalized ratio (INR) range within a therapeutic level (INR fi 3). abstract: We report on a 32-year old female patient with primary antiphospholipid syndrome (PAPS) and several thromboembolic events despite stable doses of oral anticoagulation, good patient compliance and maintained INR values of >3. Over the preceding 3 years the patient had presented a wide spectrum of manifestations of APS, including recurrent venous and arterial thromboses, cardiac, gynecological (HELLP syndrome), neurological involvements, livedo reticularis, a mild thrombocytopenia and the most feared manifestation of the catastrophic antiphospholipid syndrome (CAPS). Life-threatening bilateral subdural bleeding occurred while she was anticoagulated. The clinical features appeared to be refractory to oral anticoagulation with phenprocoumon. They were life threatening on each occasion and she developed repetitive episodes of organ damage with cardiac insufficiency (NYHA III), pulmonary hypertension and other residual defects. Even during heparinization recurrent thromboembolism supervened as well as livedo reticularis of the extremities. Lupus anticoagulants (LAC), anticardiolipin (aCL) antibodies and anti-β(2)-glycoprotein-1 (β(2)GPI) titers were all markedly elevated. This case report shows that recurrent episodes of thrombosis can occur despite seemingly adequate anticoagulation in patients with CAPS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102000/ doi: 10.1007/s10067-004-0864-0 id: cord-292561-iy06b9h9 author: Miesbach, Wolfgang title: COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation date: 2020-07-17 words: 4889.0 sentences: 262.0 pages: flesch: 45.0 cache: ./cache/cord-292561-iy06b9h9.txt txt: ./txt/cord-292561-iy06b9h9.txt summary: The novel coronavirus infection (COVID-19) is caused by the new coronavirus SARS-CoV-2 and is characterized by an exaggerated inflammatory response that can lead to severe manifestations such as adult respiratory syndrome, sepsis, coagulopathy, and death in a proportion of patients. 5 While most patients show only mild symptoms, 6 a characteristic feature of COVID-19 is that a proportion of patients develop severe complications within a short time after infection, such as adult respiratory syndrome (ARDS) or disseminated intravascular coagulation (DIC), sepsis followed by organ failure, and death. 15 These laboratory changes are consistent with previous studies which showed that hypoalbuminemia, lymphopenia, and C-reactive protein 4 mg/dL were the predictive factors for the progression of pneumonia to respiratory failure in MERS-CoV-infected patients and that elevated lactate dehydrogenase (LDH) levels were associated with hospital-acquired infection with SARS-CoV. abstract: The novel coronavirus infection (COVID-19) is caused by the new coronavirus SARS-CoV-2 and is characterized by an exaggerated inflammatory response that can lead to severe manifestations such as adult respiratory syndrome, sepsis, coagulopathy, and death in a proportion of patients. Among other factors and direct viral effects, the increase in the vasoconstrictor angiotensin II, the decrease in the vasodilator angiotensin, and the sepsis-induced release of cytokines can trigger a coagulopathy in COVID-19. A coagulopathy has been reported in up to 50% of patients with severe COVID-19 manifestations. An increase in d-dimer is the most significant change in coagulation parameters in severe COVID-19 patients, and progressively increasing values can be used as a prognostic parameter indicating a worse outcome. Limited data suggest a high incidence of deep vein thrombosis and pulmonary embolism in up to 40% of patients, despite the use of a standard dose of low-molecular-weight heparin (LMWH) in most cases. In addition, pulmonary microvascular thrombosis has been reported and may play a role in progressive lung failure. Prophylactic LMWH has been recommended by the International Society on Thrombosis and Haemostasis (ISTH) and the American Society of Hematology (ASH), but the best effective dosage is uncertain. Adapted to the individual risk of thrombosis and the d-dimer value, higher doses can be considered, especially since bleeding events in COVID-19 are rare. Besides the anticoagulant effect of LMWH, nonanticoagulant properties such as the reduction in interleukin 6 release have been shown to improve the complex picture of coagulopathy in patients with COVID-19. url: https://doi.org/10.1177/1076029620938149 doi: 10.1177/1076029620938149 id: cord-317811-mxsujb5u author: Migliaccio, Raffaella title: Dementia and COVID-19 Lockdown: More Than a Double Blow for Patients and Caregivers date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In dementia research and in clinical practice, the COVID-19 pandemic represents an important challenge, not only for neurological staff and researchers, but above all for patients and their caregivers. It is important that the medical staff demonstrate flexibility, open-mindedness, and humanity when following patients and caregivers. It seems inevitable that caregivers will pay the highest price during this crisis. url: https://doi.org/10.3233/adr-200193 doi: 10.3233/adr-200193 id: cord-275828-c6d6nk7x author: Mikasa, Keiichi title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 words: 39672.0 sentences: 2522.0 pages: flesch: 42.0 cache: ./cache/cord-275828-c6d6nk7x.txt txt: ./txt/cord-275828-c6d6nk7x.txt summary: -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 1 g/twice a day or 2 g/once a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Cases of late-onset hospital-acquired pneumonia or ventilator-associated pneumonia in which the risk of resistant bacteria is high An antimicrobial drug with anti-pseudomonal activity that targets non-glucose-fermentative gram-negative rod should be administered [50, 51, 68] -To treat polymicrobial infection, the administration of an antimicrobial drug with an activity against obligate anaerobe is not always necessary [67, 70] . -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 2 g/once a day or 1 g/twice a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Late-onset hospital-acquired pneumonia or cases in which there is a risk of multi-drug-resistant bacteria In addition to the above pathogens, the involvement of non-glucose-fermentative gram negative bacteria or ESBLproducing enteric bacteria must be considered. For the treatment of immunodeficiency-/blood disease-related pneumonia in children, antimicrobial drug therapy should also be basically selected, considering causative microorganisms. abstract: nan url: https://api.elsevier.com/content/article/pii/S1341321X16000283 doi: 10.1016/j.jiac.2015.12.019 id: cord-291417-p49ukyhx author: Mikulska, Malgorzata title: Tocilizumab and steroid treatment in patients with COVID-19 pneumonia date: 2020-08-20 words: 4441.0 sentences: 219.0 pages: flesch: 44.0 cache: ./cache/cord-291417-p49ukyhx.txt txt: ./txt/cord-291417-p49ukyhx.txt summary: METHODS: This observational single-center study included patients with COVID-19 pneumonia who were not intubated and received either standard of care (SOC, controls) or SOC plus early (within 3 days from hospital admission) anti-inflammatory treatment. This observational single-center study included patients with COVID-19 pneumonia who were not intubated and received either standard of care (SOC, controls) or SOC plus early (within 3 days from hospital admission) anti-inflammatory treatment. We hypothesized that outcomes such as no need for intubation and survival of patients with severe COVID-19 pneumonia in whom tocilizumab and/or methylprednisolone were administered in addition to standard of care (SOC) could be better than in those who received only SOC. In this observational study in non-intubated patients with mainly severe COVID-19 pneumonia, the early addition of tocilizumab and/or methylprednisolone to SOC resulted in adjusted failure-free survival of 86.5% and 80.8% at day 14 and 30, which was, respectively, 10.7% and 16.7% higher than in SOC patients. abstract: INTRODUCTION: Coronavirus disease 2019 (COVID-19) can lead to respiratory failure due to severe immune response. Treatment targeting this immune response might be beneficial but there is limited evidence on its efficacy. The aim of this study was to determine if early treatment of patients with COVID-19 pneumonia with tocilizumab and/or steroids was associated with better outcome. METHODS: This observational single-center study included patients with COVID-19 pneumonia who were not intubated and received either standard of care (SOC, controls) or SOC plus early (within 3 days from hospital admission) anti-inflammatory treatment. SOC consisted of hydroxychloroquine 400mg bid plus, in those admitted before March 24(th), also darunavir/ritonavir. Anti-inflammatory treatment consisted of either tocilizumab (8mg/kg intravenously or 162mg subcutaneously) or methylprednisolone 1 mg/kg for 5 days or both. Failure was defined as intubation or death, and the endpoints were failure-free survival (primary endpoint) and overall survival (secondary) at day 30. Difference between the groups was estimated as Hazard Ratio by a propensity score weighted Cox regression analysis (HR(OW)). RESULTS: Overall, 196 adults were included in the analyses. They were mainly male (67.4%), with comorbidities (78.1%) and severe COVID-19 pneumonia (83.7%). Median age was 67.9 years (range, 30–100) and median PaO(2)/FiO(2) 200 mmHg (IQR 133–289). Among them, 130 received early anti-inflammatory treatment with: tocilizumab (n = 29, 22.3%), methylprednisolone (n = 45, 34.6%), or both (n = 56, 43.1%). The adjusted failure-free survival among tocilizumab/methylprednisolone/SOC treated patients vs. SOC was 80.8% (95%CI, 72.8–86.7) vs. 64.1% (95%CI, 51.3–74.0), HR(OW) 0.48, 95%CI, 0.23–0.99; p = 0.049. The overall survival among tocilizumab/methylprednisolone/SOC patients vs. SOC was 85.9% (95%CI, 80.7–92.6) vs. 71.9% (95%CI, 46–73), HR(OW) 0.41, 95%CI: 0.19–0.89, p = 0.025. CONCLUSION: Early adjunctive treatment with tocilizumab, methylprednisolone or both may improve outcomes in non-intubated patients with COVID-19 pneumonia. url: https://doi.org/10.1371/journal.pone.0237831 doi: 10.1371/journal.pone.0237831 id: cord-048343-nzk8m912 author: Milbrandt, Eric B title: Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics date: 2006-11-15 words: 5789.0 sentences: 283.0 pages: flesch: 33.0 cache: ./cache/cord-048343-nzk8m912.txt txt: ./txt/cord-048343-nzk8m912.txt summary: A large number of pathophysiologic mechanisms are thought to underlie critical illness-associated cognitive dysfunction, including neuro-transmitter abnormalities and occult diffuse brain injury. Markers that could be used to evaluate the influence of specific mechanisms in individual patients include serum anticholinergic activity, certain brain proteins, and tissue sodium concentration determination via high-resolution three-dimensional magnetic resonance imaging. Many of the data supporting occult diffuse brain injury as a cause of critical illness-associated CD come from studies of sepsis and septic encephalopathy, a form of delirium. Lending support to the hypothesis that acute inflammation leads to brain injury and subsequent development of delirium, a recent study found that delirium in postoperative hipfractured patients was significantly associated with serum levels of C-reactive protein, an acute-phase protein that is a marker of acute inflammation [55] . Elevated serum S-100β levels were recently demonstrated in critically ill patients with respiratory failure [69] and in porcine models of endotoxic shock [70] and acute lung injury [71] . abstract: Cognitive dysfunction is common in critically ill patients, not only during the acute illness but also long after its resolution. A large number of pathophysiologic mechanisms are thought to underlie critical illness-associated cognitive dysfunction, including neuro-transmitter abnormalities and occult diffuse brain injury. Markers that could be used to evaluate the influence of specific mechanisms in individual patients include serum anticholinergic activity, certain brain proteins, and tissue sodium concentration determination via high-resolution three-dimensional magnetic resonance imaging. Although recent therapeutic advances in this area are exciting, they are still too immature to influence patient care. Additional research is needed if we are to understand better the relative contributions of specific mechanisms to the development of critical illness-associated cognitive dysfunction and to determine whether these mechanisms might be amenable to treatment or prevention. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794449/ doi: 10.1186/cc5078 id: cord-278672-pxzsntfg author: Milenkovic, Aleksandar title: Extensions and Adaptations of Existing Medical Information System in Order to Reduce Social Contacts During COVID-19 Pandemic date: 2020-06-16 words: 4609.0 sentences: 237.0 pages: flesch: 45.0 cache: ./cache/cord-278672-pxzsntfg.txt txt: ./txt/cord-278672-pxzsntfg.txt summary: During outbreaks, especially those with a pandemic character, the following key activities [1] which are updated with COVID-19 strategy [2] have been identified whose strict implementation has an impact on the reduction of number of infected people and suppression of the spread of epidemic: 6 . This paper presents the adaptation and extension of existing medical information system (MIS) as an efficient response to the rapid COVID-19 epidemic spread, mostly through influencing the reduction of social contacts and earliest possible identification of potentially infected persons. According to the research findings the integration of patient self-triage tools into electronic health record (EHR) systems has a great potential in improving the triage efficiency and preventing unnecessary visits during the COVID-19 pandemic. The developed subsystem for the use of existing data from MIS MEDIS.NET in the education of students at the Faculty of Medicine and newly employed workers, as well as for medical research [47] , enables tracking and studying the COVID-19 disease at this stage. abstract: OBJECTIVE: The main objective of this paper is the reduction of the COVID-19 pandemic spread by increasing the degree of social distancing by using and upgrading the existing Medical Information System (MIS). MATERIAL AND METHODS: The existing MIS MEDIS.NET, currently used in the largest health center in the Balkans, has been adapted and further developed. RESULTS: During the adaptation of existing MIS MEDIS.NET 4 new and 9 existing modules were developed. A quick questionnaire for the smart triage of patients was also implemented. DISCUSSION: The adapted MIS successfully influenced the reduction of social contacts within the Health Center Nis. The need for the arrival of children and their parents to receive appropriate health certificates for the school enrolment is reduced. The therapy of chronic patients has been prolonged for 6 months via an electronic prescription. An online service for the communication between patients and the chosen physicians is provided. Possible social contacts and exposure to the viral environment of patients are reduced by making appointments in extended slots and at determined physical locations. Patients are notified per SMS or email about the availability of chosen and physician on duty. The social distancing of patients and physicians is also established by sending laboratory analyses per email or SMS. Keeping the central registry for COVID-19 is enabled throughout the country. CONCLUSION: The smart adaptation of MIS, and its collaboration with other state systems can significantly influence the reduction of social contacts and thus mitigate the consequences of COVID-19 pandemic. url: https://www.sciencedirect.com/science/article/pii/S1386505620305700?v=s5 doi: 10.1016/j.ijmedinf.2020.104224 id: cord-302403-kahi8cbc author: Miller, Robert F. title: Pulmonary Infections date: 2009-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/B9780323048255100340 doi: 10.1016/b978-032304825-5.10034-0 id: cord-022521-r72jtoso author: Miller, Tracie L. title: Gastrointestinal Complications of Secondary Immunodeficiency Syndromes date: 2010-12-27 words: 13694.0 sentences: 812.0 pages: flesch: 36.0 cache: ./cache/cord-022521-r72jtoso.txt txt: ./txt/cord-022521-r72jtoso.txt summary: However, in the United States and other developed countries, severe malnutrition and new cases of perinatal HIV-1 disease are rare because of relatively high standards of living and effective highly active antiretroviral therapies (HAART) given to pregnant HIV-infected women that prevent transmission of HIV to the infants. Examination of both acute simian immunodeficiency virus (SIV) and HIV infection have documented reduced CD4 cell levels in GALT prior to a detectable reduction in T cells of the peripheral blood, highlighting the gastrointestinal tract''s role and susceptibility. Previous studies have shown that activated mucosal T cells play a role in the pathogenesis of enteropathy in the human small intestine 37 and can affect the morphology of the villi and crypts in a manner similar to that seen in patients with HIV-1 infection. Immune restoration disease after the treatment of immunodeficient HIV-infected patients with highly active antiretroviral therapy abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158192/ doi: 10.1016/b978-1-4377-0774-8.10042-9 id: cord-281391-0qkku2jd author: Miller-Handley, Hilary title: Treatment Options for COVID-19 in Patients with Reduced or Absent Kidney Function date: 2020-09-17 words: 4720.0 sentences: 276.0 pages: flesch: 47.0 cache: ./cache/cord-281391-0qkku2jd.txt txt: ./txt/cord-281391-0qkku2jd.txt summary: COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, was first identified in the Hubei Province of China in late 2019. Because of these findings, chloroquine and hydroxychloroquine were used as early therapies in the treatment of COVID-19, and its use was further propagated by a small, retrospective, biased study from France with 36 patients which showed decrease in viral burden, and improved outcomes in patients treated with hydroxychloroquine [17] . A retrospective study from the Veterans Affairs, looked at hospitalized patients who received hydroxychloroquine and showed no evidence that use of hydroxychloroquine reduced the risk of progression of disease including mechanical ventilation and death [20] . Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial abstract: COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, was first identified in the Hubei Province of China in late 2019. Currently the only role for therapy is treatment of the disease, as opposed to post-exposure prophylaxis, however multiple clinical trials are currently ongoing for both treatment and prophylaxis. Treating COVID-19 relies on two components; the first is inhibition of the viral entrance and replication within the body and the second is inhibition of an exacerbated immune response which can be seen in patients with severe disease. Many drugs have shown in vitro antiviral activity, however clinical trials have not been as promising. Remdesivir has shown a shortening in the time to recovery in hospitalized adults, however currently no mortality benefit demonstrated. Dexamethasone has shown improved mortality in patients requiring respiratory support, but not otherwise. Current research is ongoing in immunomodulation with monoclonal antibodies including interleukin (IL)-6 receptor antagonists and Janus Kinase (JAK) inhibitors. This review summarizes the current data for the most commonly used drugs for COVID-19, and will cover the unique factors that may affect the dosing of these medications in patients with chronic kidney disease (CKD). While clinical trials are ongoing, most are in patients with normal kidney function. During a pandemic when patients with CKD are at higher risk of both infection and death, it is imperative to include patients these patients in the clinical trials. url: https://www.sciencedirect.com/science/article/pii/S1548559520301336?v=s5 doi: 10.1053/j.ackd.2020.09.001 id: cord-301947-b6nwaost author: Millán-Oñate, José title: Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date: 2020-04-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: COVID-19 pandemics is a challenge for public health and infectious diseases clinicians, especially for the therapeutical approach that is not yet adequately defined. Amid this situation, investigational agents are being used, including chloroquine. We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. CASE PRESENTATION: A 34-year-old male, returning from Spain, presented with complaints of fever, and cough, and class-II obesity, being hospitalized. The respiratory viruses and bacteria tested by FilmArray(®) PCR were negative. Two days later, clarithromycin was started because the patient was suspected as community-acquired pneumonia. At the third day, the rRT-PCR confirmed the SARS-CoV-2 infection. A day later, chloroquine was started because of that. His chest computed tomography was performed and showed bilateral multifocal ground-glass opacities with consolidation, which suggested viral pneumonia as a differential diagnosis. Progressively his clinical condition improved and at day 9, patient rRT-PCR for SARS-CoV-2 became negative. The patient was discharged and isolated at home per 14 days. CONCLUSIONS: Our patient improved significantly. This and other COVID-19 cases are urgently demanding results from clinical trials that support evidence-based therapeutical approaches to this pandemic and the clinical management of patients, especially those at critical care. url: https://doi.org/10.1186/s12941-020-00358-y doi: 10.1186/s12941-020-00358-y id: cord-298403-ilpzj2sv author: Mintz, Yoav title: Minimally Invasive Surgery is the Key to Patient and Operating room team Safety During the COVID19 Pandemic as well as in the “new normal” or chronic Pandemic State to come date: 2020-08-18 words: 745.0 sentences: 40.0 pages: flesch: 35.0 cache: ./cache/cord-298403-ilpzj2sv.txt txt: ./txt/cord-298403-ilpzj2sv.txt summary: title: Minimally Invasive Surgery is the Key to Patient and Operating room team Safety During the COVID19 Pandemic as well as in the "new normal" or chronic Pandemic State to come In cases of emergency or oncological surgery the decision whether to perform abdominal surgery by laparotomy or laparoscopy is dependent on the COVID-19 status, the complexity of the operation, and the respiratory status. Patients with moderately compromised respiratory function requiring mask oxygen therapy or non-invasive ventilation (i.e. Continuous Positive Airway Pressure) can also be operated safely by laparoscopy. Patients with moderately to severely compromised respiratory function with interstitial pneumonia and ARDS, who are ventilated but have good respiratory system compliance (> 50 ml/cm H 2 O) can be safely operated via laparoscopy. At the present time, aside from the potential pulmonary repercussions, there is no evidence that laparoscopy is more dangerous than laparotomy for patients with COVID-19 disease 5 . abstract: nan url: https://doi.org/10.1002/bjs.11916 doi: 10.1002/bjs.11916 id: cord-269345-5tlyy8jp author: Minuz, Pietro title: High rate of pulmonary thromboembolism in patients with SARS-CoV-2 pneumonia date: 2020-06-18 words: 690.0 sentences: 46.0 pages: flesch: 54.0 cache: ./cache/cord-269345-5tlyy8jp.txt txt: ./txt/cord-269345-5tlyy8jp.txt summary: Recently, thromboembolic events have been reported in 20/81 patients with severe SARS-CoV-2 32 pneumonia admitted to intensive care units (ICUs). In our case series, the involvement of segmental and subsegmental branches of the pulmonary 75 arteries along with the peculiar multiple and bilateral filling defects distribution, suggest a non-76 embolic origin of the pulmonary arteries thrombosis [4] . Compared to the rates previously reported in patients with pneumonia or other severe infections, a 81 higher prevalence of PTE in patients with SARS-CoV-2 pneumonia might be inferred from this 82 small series. The absence of major risk factors for thromboembolic events in 5 out of 6 patients 83 seems to further confirm the role of bilateral SARS-CoV-2 pneumonia as a risk factor for PTE. Prevalence of venous thromboembolism in patients with 119 severe novel coronavirus pneumonia abstract: nan url: https://doi.org/10.1016/j.cmi.2020.06.011 doi: 10.1016/j.cmi.2020.06.011 id: cord-346894-iy35298o author: Miranda-Schaeubinger, Monica title: A primer for pediatric radiologists on infection control in an era of COVID-19 date: 2020-07-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Pediatric radiology departments across the globe face unique challenges in the midst of the current COVID-19 pandemic that have not been addressed in professional guidelines. Providing a safe environment for personnel while continuing to deliver optimal care to patients is feasible when abiding by fundamental recommendations. In this article, we review current infection control practices across the multiple pediatric institutions represented on the Society for Pediatric Radiology (SPR) Quality and Safety committee. We discuss the routes of infectious transmission and appropriate transmission-based precautions, in addition to exploring strategies to optimize personal protective equipment (PPE) supplies. This work serves as a summary of current evidence-based recommendations for infection control, and current best practices specific to pediatric radiologists. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00247-020-04713-1) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s00247-020-04713-1 doi: 10.1007/s00247-020-04713-1 id: cord-258128-qtmjgrml author: Mirjalili, Mahtabalsadat title: Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen date: 2020-07-03 words: 6450.0 sentences: 369.0 pages: flesch: 38.0 cache: ./cache/cord-258128-qtmjgrml.txt txt: ./txt/cord-258128-qtmjgrml.txt summary: 12 In one case report regarding the successful treatment of a kidney transplant recipient with pneumonia caused by SARS-CoV-2 in China, all the immunosuppressants were stopped and the patient received 5 g intravenous immunoglobulin (IVIG) on the first day and then 10 g/day for the next 11 days, with 40 mg/day methylprednisolone for 12 days and 5 million units/day interferon as atomization inhalation. 17, 18 Considering that adverse clinical outcomes and increased mortality and morbidity following the administration of corticosteroids in patients with respiratory infections caused by respiratory syncytial virus (RSV), influenza, SARS-CoV-1, or MERS-CoV may be due to an increased risk of secondary bacterial infections, their use for the prevention of disease progression or its treatment remains under discussion. So far, few studies have been conducted regarding the use of this drug in liver and kidney transplant patients, but if it is administered to this population, its adverse effects and interactions with immunosuppressants and other medications used in transplant patients, such as fluoroquinolones for the treatment of Gram-negative infections, should be considered. abstract: The 2019 novel coronavirus disease (COVID-19) was first detected in Wuhan, Hubei Province, China, in late 2019. Since then, COVID-19 has spread to more than 200 countries in the world, and a global pandemic has been declared by the World Health Organization (WHO). At present, no vaccines or therapeutic regimens with proven efficacy are available for the management of COVID-19. Hydroxychloroquine/chloroquine, lopinavir/ritonavir, ribavirin, interferons, umifenovir, remdesivir, and interleukin antagonists, such as tocilizumab, have been recommended as potential treatment options in COVID-19. Transplant patients receiving immunosuppressant medications are at the highest risk of severe illness from COVID-19. At the same time, with regard to receiving polypharmacy and immunosuppressants, treatment options should be chosen with more attention in this population. Considering drug–drug interactions and adverse effects of medications used for the treatment of COVID-19, such as QT prolongation, the dose reduction of some immunosuppressants or avoidance is recommended in transplant recipients with COVID-19. Thus, this narrative review describes clinically important considerations about the treatment of COVID-19 and immunosuppressive regimens regarding modifications, side effects, and interactions in adult kidney or liver allograft recipients. url: https://doi.org/10.2147/tcrm.s256246 doi: 10.2147/tcrm.s256246 id: cord-278838-qraq5aho author: Mirouse, Adrien title: Severe varicella-zoster virus pneumonia: a multicenter cohort study date: 2017-06-07 words: 4702.0 sentences: 261.0 pages: flesch: 44.0 cache: ./cache/cord-278838-qraq5aho.txt txt: ./txt/cord-278838-qraq5aho.txt summary: Half the patients received mechanical ventilation within 1 (1–2) day following ICU admission (the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO(2)/FiO(2)) = 150 (80–284), 80% with acute respiratory distress syndrome (ARDS)). Sequential Organ Failure Assessment (SOFA) score on day 1 (odds ratio (OR) 1.90 (1.33–2.70); p < 0.001), oxygen flow at ICU admission (OR 1.25 (1.08–1.45); p = 0.004), and early bacterial co-infection (OR 14.94 (2.00–111.8); p = 0.009) were independently associated with the need for mechanical ventilation. Results are presented for the imputed data Candidate predictors were: age, any comorbidity, underlying immunosuppression, SOFA score at day 1, oxygen flow at ICU admission, alveolar consolidation on chest X-ray, antibiotics at ICU admission, and early bacterial co-infection CI confidence interval, ICU intensive care unit, OR odds ratio, SOFA Sequential Organ Failure Assessment In our study, the overall mortality was 24% and reached 43% in patients who received invasive mechanical ventilation. abstract: BACKGROUND: Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP). METHODS: This was an observational study of patients with VZV-CAP admitted to 29 intensive care units (ICUs) from January 1996 to January 2015. RESULTS: One hundred and two patients with VZV-CAP were included. Patients were young (age 39 years (interquartile range 32–51)) and 53 (52%) were immunocompromised. Time since respiratory symptom onset was 2 (1–3) days. There was a seasonal distribution of the disease, with more cases during spring and winter time. All but four patients presented with typical skin rash on ICU admission. Half the patients received mechanical ventilation within 1 (1–2) day following ICU admission (the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO(2)/FiO(2)) = 150 (80–284), 80% with acute respiratory distress syndrome (ARDS)). Sequential Organ Failure Assessment (SOFA) score on day 1 (odds ratio (OR) 1.90 (1.33–2.70); p < 0.001), oxygen flow at ICU admission (OR 1.25 (1.08–1.45); p = 0.004), and early bacterial co-infection (OR 14.94 (2.00–111.8); p = 0.009) were independently associated with the need for mechanical ventilation. Duration of mechanical ventilation was 14 (7–21) days. ICU and hospital mortality rates were 17% and 24%, respectively. All patients were treated with aciclovir and 10 received adjunctive therapy with steroids. Compared to 60 matched steroid-free controls, patients treated with steroids had a longer mechanical ventilation duration, ICU length of stay, and a similar hospital mortality, but experienced more ICU-acquired infections. CONCLUSIONS: Severe VZV-CAP is responsible for an acute pulmonary involvement associated with a significant morbidity and mortality. Steroid therapy did not influence mortality, but increased the risk of superinfection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13054-017-1731-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/28592328/ doi: 10.1186/s13054-017-1731-0 id: cord-291340-8gj0ofmp author: Misra, Anoop title: Balanced Nutrition is Needed in Times of COVID19 Epidemic in India: A Call for Action for all Nutritionists and Physicians date: 2020-08-27 words: 2147.0 sentences: 123.0 pages: flesch: 40.0 cache: ./cache/cord-291340-8gj0ofmp.txt txt: ./txt/cord-291340-8gj0ofmp.txt summary: In a Cochrane review [26] , and other studies [27] probiotics were shown to decrease upper respiratory infections through their effect on the gut lung axis [28] Role of several other nutrients and food constituents like Vitamins(E, B) Carotenoids, minerals (Fe, Zn, Mg, Cu, Se), and polyphenols in immunity have been suggested because of their effects on inflammatory cascade, antioxidant activities and effects on nitrous oxide signalling pathways [25] (Table 1) . Controlled trials also show reduced complications when serum albumin level is adequate [44] .In a recent scoping review(four studies in patients with ventilator-related pneumonia and acute respiratory distress syndrome, and the other 4 in patients with ventilator-associated pneumonia), intravenous ascorbic acid, intramuscular cholecalciferol, enteral and intramuscular vitamin E, enteral zinc sulphate, and oral and parenteral glutamine were given as interventions. abstract: nan url: https://doi.org/10.1016/j.dsx.2020.08.030 doi: 10.1016/j.dsx.2020.08.030 id: cord-323647-q67fa0m3 author: Misra, Durga Prasanna title: Benefits and adverse effects of hydroxychloroquine, methotrexate and colchicine: searching for repurposable drug candidates date: 2020-09-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Repurposing of antirheumatic drugs has garnered global attention. The aim of this article is to overview available evidence on the use of widely used antirheumatic drugs hydroxychloroquine, methotrexate and colchicine for additional indications. Hydroxychloroquine has endothelial stabilizing and anti-thrombotic effects. Its use has been explored as an adjunctive therapy in refractory thrombosis in antiphospholipid syndrome. It may also prevent recurrent pregnancy losses in the absence of antiphospholipid antibodies. Hydroxychloroquine favourably modulates atherogenic lipid and glycaemic profiles. Methotrexate has been tried for modulation of cardiovascular events in non-rheumatic clinical conditions, although a large clinical trial failed to demonstrate a benefit. Colchicine has been shown to successfully reduce the risk of recurrent cardiovascular events in a large multicentric trial. Potential antifibrotic effects of colchicine require further exploration. Hydroxychloroquine, methotrexate and colchicine are also being tried at different stages of the ongoing Coronavirus Disease 19 (COVID-19) pandemic for prophylaxis and treatment. While the use of these agents is being diversified, their adverse effects should be timely diagnosed and prevented. Hydroxychloroquine can cause retinopathy and rarely cardiac and auditory toxicity, retinopathy being dose and time dependent. Methotrexate can cause transaminitis, cytopenias and renal failure, particularly in acute overdoses. Colchicine can rarely cause myopathies, cardiomyopathy, cytopenias and transaminitis. Strong evidence is warranted to keep balance between benefits of repurposing these old antirheumatic drugs and risk of their adverse effects. url: https://doi.org/10.1007/s00296-020-04694-2 doi: 10.1007/s00296-020-04694-2 id: cord-018454-sy21cpff author: Mitrovic, Stéphane title: Adult-Onset Still’s Disease date: 2019-10-30 words: 9387.0 sentences: 495.0 pages: flesch: 41.0 cache: ./cache/cord-018454-sy21cpff.txt txt: ./txt/cord-018454-sy21cpff.txt summary: (continued) Identifying the disease subset might orientate the therapeutic strategy c Serum ferritin levels are significantly higher in the systemic subtype [110] , but high ferritin levels after adequate treatment may predict chronic articular course [61] d Calprotectin levels help rule out rheumatoid arthritis, but further studies are needed to validate it as a diagnostic biomarker because of no statistical difference between AoSD and septic patients, although the populations were small [42] e Elevated plasma levels of IL-1β, IL-6, and TNFα have been found during AoSD, but the cytokine profile is not specific and cannot differentiate AoSD patients from those with sepsis f S100A12 was found an efficient diagnostic and monitoring biomarker in systemic juvenile arthritis, but further studies are needed for validation in AoSD Procalcitonin, a marker of severe systemic infection, was also found elevated in patients with active AoSD and does not appear relevant to distinguish acute infection from AoSD flare [42, 113] . abstract: Adult-onset Still’s disease (AoSD) is a rare but clinically well-known, polygenic, systemic autoinflammatory disease. It is typically characterized by four main (cardinal) symptoms: spiking fever ≥39 °C, arthralgia or arthritis, skin rash, and hyperleukocytosis (≥10,000 cells/mm(3)). However, many other clinical features are possible, and it can appear in all age groups with potentially severe inflammatory onset accompanied by a broad spectrum of disease manifestation and complications. Hence, it remains a diagnostic challenge, and the clinician should first rule out infectious, tumoral, or inflammatory differential diagnoses. Determination of the total and glycosylated ferritin levels, although not pathognomonic, can help in diagnosis. New biomarkers have recently been described, but they need to be validated. The disease evolution of AoSD can be monocyclic, polycyclic, or chronic. In chronic disease, a joint involvement is often predominant, and erosions are noted in one-third of patients. Many progresses have been made in the understanding of the pathogenesis over the last decades. This chapter provides a comprehensive insight into the complex and heterogeneous nature of AoSD describing the identified cytokine signaling pathways and biomarkers. It also discusses the current evidence for the usage of biologics in AoSD to provide guidance for treatment decisions, taking into account both the efficacy and the safety of the different therapeutic options. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123329/ doi: 10.1007/978-3-030-19055-2_6 id: cord-324944-ixh3ykrc author: Mitsakakis, Konstantinos title: Diagnostic tools for tackling febrile illness and enhancing patient management date: 2018-12-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Most patients with acute infectious diseases develop fever, which is frequently a reason to visit health facilities in resource-limited settings. The symptomatic overlap between febrile diseases impedes their diagnosis on clinical grounds. Therefore, the World Health Organization promotes an integrated management of febrile illness. Along this line, we present an overview of endemic and epidemic etiologies of fever and state-of-the-art diagnostic tools used in the field. It becomes evident that there is an urgent need for the development of novel technologies to fulfill end-users' requirements. This need can be met with point-of-care and near-patient diagnostic platforms, as well as e-Health clinical algorithms, which co-assess test results with key clinical elements and biosensors, assisting clinicians in patient triage and management, thus enhancing disease surveillance and outbreak alerts. This review gives an overview of diagnostic technologies featuring a platform based approach: (i) assay (nucleic acid amplification technologies are examined); (ii) cartridge (microfluidic technologies are presented); (iii) instrument (various detection technologies are discussed); and at the end proposes a way that such technologies can be interfaced with electronic clinical decision-making algorithms towards a broad and complete diagnostic ecosystem. url: https://www.sciencedirect.com/science/article/pii/S0167931718304556 doi: 10.1016/j.mee.2018.10.001 id: cord-302389-h7jm1etb author: Moazenzadeh, Mansoor title: First reported case of unrepaired tetralogy of Fallot complicated with coronavirus disease-19 (COVID-19) date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The incidence of novel coronavirus disease-19 (nCoV-19) and its associated complications is higher in high-risk groups. In this article, we explain the symptoms and course of the disease and the treatment for an adult patient with CHD who has been infected with novel nCoV-19. url: https://doi.org/10.1017/s1047951120001821 doi: 10.1017/s1047951120001821 id: cord-007833-wkv808ix author: Modi, Dipenkumar title: Pomalidomide-Induced Pulmonary Toxicity in Multiple Myeloma date: 2015-12-16 words: 1338.0 sentences: 101.0 pages: flesch: 44.0 cache: ./cache/cord-007833-wkv808ix.txt txt: ./txt/cord-007833-wkv808ix.txt summary: In this article, the authors report an additional case of pomalidomide-induced pulmonary toxicity based on temporal relationship between drug administration and onset of symptoms as well as characteristic imaging findings. Lenalidomide and bortezomib were discontinued, and he was initiated on pomalidomide 4 mg/d, days 1 through 21 with dexamethasone 20 mg once weekly. Approximately 8 months after starting treatment with pomalidomide, the patient developed fever, progressive dyspnea, productive cough, and generalized weakness for 5 days duration before presenting to the hospital. The patient''s recurrence and resolution of symptoms in a temporal relationship to therapy with pomalidomide, along with ground glass opacities on CT, led to a strong suspicion of pomalidomide-induced pulmonary toxicity. 3, 4 Pulmonary toxicity is an uncommon but increasingly reported clinical complication of IMiD agents, particularly thalidomide and lenalidomide. Usual time interval between initiation of treatment to onset of symptoms is 8 to 120 days, but toxicity from pomalidomide may be delayed. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124277/ doi: 10.1097/maj.0000000000000532 id: cord-326994-y8p724s4 author: Mohamad, Osama title: Delaying Dilemmas: Coronavirus Complications Impacting the Management of Prostate Cancer date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S036030162031405X doi: 10.1016/j.ijrobp.2020.07.009 id: cord-318520-hgjv7ot9 author: Mohamed, Sherif title: Death due to Cardiac Arrest in a Young Female With Highly Suspected COVID-19: A Case Report date: 2020-08-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Despite the common clinical presentations of the pandemic coronavirus disease of 2019 (COVID-19) being well-known, there remain issues on its atypical or rare presentations. Moreover, despite the known risk factors for severe COVID-19 are cardiovascular disease, diabetes mellitus, hypertension, chronic lung disease, and advanced age, still younger patients suffer from this disease. Herein, we present a case report of a 28-year-old female patient who was presented to the ED with cardiac arrest, then died within 12 hours. First swab testing by reverse transcription-polymerase chain reaction (RT-PCR) came negative. However, she has typical CT features of COVID-19 pneumonia, along with an echocardiographic picture of acute cor pulmonale. Though it is rare, cardiac arrest can happen in young apparently healthy patients with COVID-19. As COVID-19 patients are commonly having clotting disorders, endothelial and organ dysfunction, coagulopathy, and liable for pulmonary thromboembolism (PTE), it is important to select those COVID-19 patients who are at higher risk of PTE, and practice CT pulmonary angiography (CTPA) for the diagnosis of PTE, especially in case of significant increase of D-dimer values. url: https://doi.org/10.7759/cureus.10127 doi: 10.7759/cureus.10127 id: cord-026868-z9gozm2w author: Mohammad, Abeer title: “She’s dead!” – Nursing simulation practices: A discourse analysis approach date: 2020-06-11 words: 5467.0 sentences: 245.0 pages: flesch: 44.0 cache: ./cache/cord-026868-z9gozm2w.txt txt: ./txt/cord-026868-z9gozm2w.txt summary: This high prevalence of simulation practices in nursing programs has led to opportunities to research this topic from various angles, including its impact on students'' skill performance, self-efficacy, self-confidence, self-satisfaction, and clinical knowledge acquisition. Results: The analyses revealed various training and communication issues including the lack of harmony among the team members (e.g., regarding understanding and performing their assigned roles as well as delegating and conducting delegated tasks) and the students'' inability to effectively communicate with the patient as a valuable source of information and to make appropriate and timely clinical decisions regarding patient assessment. 2 This widespread use of simulations in nursing programs has led to opportunities to research this topic from many angles, including its impact on students'' skill performance, 6, 7 self-efficacy, [8] [9] [10] self-confidence and satisfaction, [11] [12] [13] and, most importantly, clinical knowledge acquisition. abstract: Background: The literature on nursing education has revealed a growing wave of interest in the use of simulation sessions to promote undergraduate nurses’ learning experiences. This high prevalence of simulation practices in nursing programs has led to opportunities to research this topic from various angles, including its impact on students’ skill performance, self-efficacy, self-confidence, self-satisfaction, and clinical knowledge acquisition. Design and Methods: Participants in this qualitative study included 54 senior female undergraduates enrolled in a critical care nursing course in Saudi Arabia. Recordings were made of six authentic, acute care simulation sessions. One of these sessions was examined in depth using discourse analysis approaches to gain insights into communication in simulation sessions, examining the way students linguistically managed this critical communication, exhibiting their logical, reflective, decision-making, problem-solving, and collaborative work skills and use of communicative strategies. Results: The analyses revealed various training and communication issues including the lack of harmony among the team members (e.g., regarding understanding and performing their assigned roles as well as delegating and conducting delegated tasks) and the students’ inability to effectively communicate with the patient as a valuable source of information and to make appropriate and timely clinical decisions regarding patient assessment. Conclusions: Simulation sessions have been shown to be a promising instructional tool to support nursing education, allowing students to practice in a safe and controlled environment. However, for more effective sessions and to avoid poor simulation sessions, students need to be thoroughly briefed regarding the sessions prior to implementation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296278/ doi: 10.4081/jphr.2020.1784 id: cord-328786-gkd9xcxa author: Mohammad, Laila Malani title: Necessity of brain imaging in COVID-19 infected patients presenting with acute neurological deficits date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Patients undergoing cardiopulmonary stabilization in the intensive care unit for novel coronavirus (COVID-19) are often sedated, placing timely assessment of a neurological decline at risk. CASE DESCRIPTION: Here, we present two cases of COVID-19 infected young patients transferred to our facility in a cardio-pulmonary crisis, with a poor neurological exam. While there was significant delay in obtaining brain imaging in the first patient, the second patient had timely recognition of her ischemic infarct, underwent emergent surgery, and is now doing well. CONCLUSIONS: These cases highlight the importance of early head imaging in COVID-19 patients with a poor neurological exam. While lungs remain the primary target of COVID-19, these cases alert the medical community to suspect involvement of the central nervous system, since there may be life-saving surgical interventions available. url: https://doi.org/10.1016/j.inat.2020.100883 doi: 10.1016/j.inat.2020.100883 id: cord-030361-0tepkjdl author: Mohammed Abdul, Mubeen Khan title: Hepatitis C Virus in the Elderly in the Direct-Acting Antiviral Era: from Diagnosis to Cure date: 2020-08-11 words: 4991.0 sentences: 233.0 pages: flesch: 42.0 cache: ./cache/cord-030361-0tepkjdl.txt txt: ./txt/cord-030361-0tepkjdl.txt summary: In a study conducted by Foster and colleagues, data was combined from nine phase 2 and phase 3 clinical trials to evaluate efficacy and safety outcomes in HCV patients ≥ 65 years old treated with the pan-genotypic regimen, glecaprevir/pibrentasvir, for 8, 12, or 16 weeks [28] . Shiffman and colleagues reported outcomes of 123 patients aged 65 years or older enrolled in three phase 3 studies who received sofosbuvir/velpatasvir, a pan-genotypic DAA, for 12 weeks for the treatment of chronic HCV [29] . Safety and efficacy of sofosbuvir/ velpatasvir for the treatment of chronic hepatitis C in patients aged 65 years or older: a retrospective analysis of phase 3 studies The efficacy and safety of direct acting antiviral treatment and clinical significance of drug-drug interactions in elderly patients with chronic hepatitis C virus infection abstract: PURPOSE OF REVIEW: Hepatitis C (HCV) is the most common cause of viral hepatitis in elderly individuals. This patient population previously experienced suboptimal outcomes with interferon-based regimens. Unfortunately, patients aged 65 years and older were underrepresented in phase 2 and 3 clinical trials with newer direct acting antiviral (DAA) therapies. Since the advent of second-generation DAA in 2013, numerous robust real-world experiences highlighting the efficacy and safety of DAA in the elderly have been published. This review article summarizes the cascade of care for hepatitis C from diagnosis to cure from an evidence-based perspective of the aging population. RECENT FINDING: In a large study from the Veterans Affairs Healthcare System, the overall sustained virologic response (SVR) of 15,884 patients treated with DAA regimens was 91.2%. These newer therapies remained highly effective in the subset of patients aged 65 years and older with SVR rates above 90%. A Spanish National Registry reported outcomes in patients ≥ 65 years old treated for HCV with oral DAA regimens over a 2-year period. The overall SVR was 94% in the study of 1252 subjects. SUMMARY: Current real-world data imply DAA treatment regimens remain highly effective and safe in elderly patients when compared to the general population. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418288/ doi: 10.1007/s40506-020-00231-8 id: cord-278364-58d8kfdf author: Mohapatra, S. title: Sterilization and Disinfection date: 2017-03-31 words: 6548.0 sentences: 434.0 pages: flesch: 49.0 cache: ./cache/cord-278364-58d8kfdf.txt txt: ./txt/cord-278364-58d8kfdf.txt summary: The medical device or the surgical instrument that comes in contact with the sterile tissue or the mucus membrane of the patient during the various processes is associated with increased risk of introduction of pathogens into the patient''s body. Moreover, there is chance of transmission of infection from patient to patient; from patient or to health care personnel, and vice versa; or from the environment to the patient through the improper sterilized or disinfected devices. Patients care equipment are divided into three categories (critical, semicritical, and noncritical) depending on the intended use and risk of transmission of infection. These items do not need sterilization; however, they should be regularly cleaned and disinfected with LLD to decrease the transmission of infective organisms (Table 59 .6). Various recommendations for the prevention of VAP include (1) appropriate cleaning, disinfection, and sterilization of ventilator equipment, (2) maintenance of ventilator circuits, and (3) routine care of patients requiring ventilation. abstract: Sterilization and disinfection are the basic components of hospital infection control activities. Every day, a number of hospitals are performing various surgical procedures. Even more number of invasive procedures are being performed in different health care facilities. The medical device or the surgical instrument that comes in contact with the sterile tissue or the mucus membrane of the patient during the various processes is associated with increased risk of introduction of pathogens into the patient's body. Moreover, there is chance of transmission of infection from patient to patient; from patient or to health care personnel, and vice versa; or from the environment to the patient through the improper sterilized or disinfected devices. Hence, medical personnel, laboratory people and the health care providers should have better knowledge regarding these techniques to prevent the spread of these pathogens. url: https://www.sciencedirect.com/science/article/pii/B9780128052990000592 doi: 10.1016/b978-0-12-805299-0.00059-2 id: cord-300510-fhpkdqr0 author: Mojoli, Francesco title: Our recommendations for acute management of COVID-19 date: 2020-05-08 words: 1083.0 sentences: 73.0 pages: flesch: 41.0 cache: ./cache/cord-300510-fhpkdqr0.txt txt: ./txt/cord-300510-fhpkdqr0.txt summary: 7. Perform early intubation if poor response to continuous positive airway pressure in terms of oxygenation: do not trust patients'' relatively good respiratory mechanics and feeling of improved dyspnoea, since these patients may have relatively normal lung compliance and the only clinical sign of fatigue may be high respiratory rate. As soon as possible according to gas exchanges (PaO 2 /FiO 2 > 150 with FiO2 < 50%) and lung ultrasound score (≤ 12), start assisted ventilation with a sigh while maintaining moderate to high positive end-expiratory pressure to prevent derecruitment. Abbreviations SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2; ICU: Intensive care unit Assessment of lung aeration and recruitment by CT scan and ultrasound in acute respiratory distress syndrome patients Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China The authors read and approved the final manuscript. abstract: nan url: https://doi.org/10.1186/s13054-020-02930-6 doi: 10.1186/s13054-020-02930-6 id: cord-355190-ytdw1d5v author: Mok, Chi Chiu title: Trend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years date: 2020-09-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objectives: To revisit the trend of survival of systemic lupus erythematosus in a cohort of Chinese patients over 25 years. Methods: Patients who fulfilled the 1997 ACR criteria for SLE and were followed in our hospital since 1995 were included. Patients were stratified into two groups according to the year of diagnosis: (1) 1995–2004 and (2) 2005–2018. Survival of patients was studied by Kaplan–Meier analysis. Organ damage as assessed by the Systemic Lupus International Collaborating Clinics (SLICC) damage index (SDI) and causes of death in the first 10 years of SLE onset was compared between the two groups. Cox regression was used to study factors associated with survival. Results: A total of 1,098 SLE patients were registered in our database. After excluding 157 patients diagnosed outside the time period of 1995–2018, 941 patients were studied (92% women). All were ethnic Chinese. The mean age of SLE onset was 35.1 ± 14.4 years, and the mean duration of observation was 13.1 ± 6.6 years. Seventy-seven (8.2%) patients were lost to follow-up. Groups 1 and 2 consisted of 364 and 577 patients, respectively. The mean SDI score at 10 years of disease onset was significantly higher in group 1 than group 2 patients (1.01 ± 1.43 vs. 0.57 ± 0.94; p < 0.01), particularly in the neuropsychiatric, musculoskeletal, and gonadal domains. Within 10 years of SLE onset, 32 (8.8%) patients in group 1 and 25 (4.3%) patients in group 2 died (p = 0.005). The 5- and 10-year cumulative survival rates were 93.6 and 91.0% in group 1 and 96.5 and 94.2% in group 2 patients, respectively (log-rank test p = 0.048). Infection accounted for more than half of the deaths in both groups. More group 1 than group 2 patients died of vascular events, but the difference was not statistically significant. Cox regression showed that the age of SLE onset and damage score accrued at 10 years, but not the time period in which SLE was diagnosed, were significantly associated with mortality. Conclusions: The improvement in survival of our SLE patients is probably related to the accrual of less organ damage in the past 15 years. url: https://www.ncbi.nlm.nih.gov/pubmed/33015102/ doi: 10.3389/fmed.2020.00552 id: cord-276676-lgt0rzob author: Moka, Eleni title: Best Practice in Cardiac Anesthesia during the COVID-19 Pandemic: Practical Recommendations date: 2020-07-03 words: 5882.0 sentences: 274.0 pages: flesch: 35.0 cache: ./cache/cord-276676-lgt0rzob.txt txt: ./txt/cord-276676-lgt0rzob.txt summary: Indeed, the pandemic has already affected cardiac surgery units in multiple ways: limited number of available ICU beds and ventilation sites, necessity to postpone or cancel elective and/or complex cardiac interventional procedures, patients developing COVID-19 post cardiac surgery, coronavirus patients necessitating urgent cardiac operations, cardiac anesthetists'' in-hospital transfer to staff and support ICUs in front of the pandemic, infected health care providers with consequent shortage of medical and nursing practitioners, restrictions in clinical meetings, and cancelation of training and continuing medical education [6, 8] . Based on the current understanding of COVID-19 pathophysiology and the clinical characteristics of cardiovascular surgical patients, in this review, the authors highlight related anesthesia concerns and provide practical recommendations in reference to perioperative planning and management of patients undergoing cardiac surgery, along with a focus on disease control and prevention in the times of COVID-19 outbreak. abstract: The COVID-19 outbreak has influenced the entire health care system, including cardiac surgery. In this review, the authors reveal practical aspects that are important during the COVID-19 pandemic with regards to the safe delivery of cardiac anesthesia. Timing for operations of the cardio-vascular system may be well programmed, in most cases. Hence, the level of priorities must be defined for any single patient. The postponement of surgery may be convenient for most cases, if it is made in the best interest of the patient. The preanesthetic evaluation should keep attention to the respiratory history of the patient. Cardiac anesthesia is always implying some respiratory monitoring; hence the existing clinical situation of the patient’s respiratory system should be clear. In case of emergency surgery, the patient should be treated as if they potentially have or are at risk for the virus. In the case of a COVID-19 confirmed or suspected patient, attention must be made to preserve operating room and team integrity. The machineries are to be draped with plastic, in order to simplify the disinfection after the operation. Perioperative management of suspected or confirmed COVID-19 patients must strictly follow the most relevant international guidelines. This review article has synthesized the common aspect present in the most important of these. url: https://www.sciencedirect.com/science/article/pii/S1521689620300495?v=s5 doi: 10.1016/j.bpa.2020.06.008 id: cord-264829-ynel6ore author: Momtazmanesh, Sara title: Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool date: 2020-07-13 words: 7952.0 sentences: 447.0 pages: flesch: 48.0 cache: ./cache/cord-264829-ynel6ore.txt txt: ./txt/cord-264829-ynel6ore.txt summary: The aims of this systematic review and meta-analyses were (1) to calculate pooled frequency of newly developed and pre-existing CVD, hypertension, diabetes mellitus, cardiac symptoms as the initial presentations of COVID-19, elevation of cardiac and inflammatory biomarkers, acute hepatic, and renal injury; (2) to investigate association of newly developed and pre-existing CVD (including any acquired cardiac disease, encompassing ischemic and non-ischemic cardiomyopathies, or congenital heart disease) hypertension, and elevated cardiac and inflammatory biomarkers with severity of the disease and mortality; (3) to define the clinical spectrum and mechanisms of the newly developed cardiovascular diseases in the pediatric and adult population, the spectrum of newly developed arrhythmias and electrocardiographic changes and the pathologic findings of cardiac autopsies; and (4) to propose a TRST for timely detection and appropriate pathophysiologically targeted treatment of high-risk COVID-19 patients with associated CVD. abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) pandemic has drastically affected global health. Despite several studies, there is yet a dearth of data regarding the mechanisms of cardiac injury, clinical presentation, risk factors, and treatment of COVID-19-associated cardiovascular disease. This systematic review and meta-analysis is aimed at defining the clinical, electrocardiographic, and pathologic spectrum of cardiovascular disease (CVD), frequency of elevated cardiac and inflammatory biomarkers, and their frequency and relationship with severity of the disease and mortality in COVID-19 patients and to develop a triage risk stratification tool (TRST) that can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. We conducted an online search in databases of PubMed and Embase to identify relevant studies. Data selection was in concordance with PRISMA guidelines. Results were presented as pooled frequencies, odds ratio, standardized mean difference (SMD), and forest and funnel plots. RESULTS: We gathered a total of 54 studies and included 35 of them in our meta-analysis. Acute cardiac injury occurred in more than 25% of cases, mortality was 20 times higher, and admission to intensive care unit increased by 13.5 times. Hypertension was the most common pre-existing comorbidity with a frequency of 29.2%, followed by diabetes mellitus (13.5%). The deceased group of patients had higher cardiac and inflammatory biomarkers, with statistically significant SMD, compared with survivors. Pediatric patients were predominantly mildly affected. However, less frequently, the presentation was very similar to Kawasaki disease or Kawasaki shock syndrome. This latter presentation hass been called as multisystem inflammatory syndrome in children (MIS-C). CONCLUSIONS: There is a wide spectrum of cardiac involvement in COVID-19 patients, and hence a Triage Risk Stratification Tool can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. url: https://doi.org/10.1186/s43044-020-00075-z doi: 10.1186/s43044-020-00075-z id: cord-029183-3aotgq6m author: Monard, Céline title: Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Improving timeliness of pathogen identification is crucial to allow early adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance of a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples to guide empirical antimicrobial therapy in adult patients with community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP), and ventilator-acquired pneumonia (VAP). METHODS: This retrospective multicenter study was conducted in four French university hospitals. Respiratory samples were obtained from patients with clinical and radiological signs of pneumonia and simultaneously tested using conventional microbiological methods and the rm-PCR. A committee composed of an intensivist, a microbiologist, and an infectious diseases specialist retrospectively assessed all medical files and agreed on the most appropriate antimicrobial therapy for each pneumonia episode, according to the results of rm-PCR and blinded to the culture results. The rm-PCR-guided antimicrobial regimen was compared to the empirical treatment routinely administered to the patient in standard care. RESULTS: We included 159 pneumonia episodes. Most patients were hospitalized in intensive care units (n = 129, 81%), and episodes were HAP (n = 68, 43%), CAP (n = 54, 34%), and VAP (n = 37, 23%). Conventional culture isolated ≥ 1 microorganism(s) at significant level in 95 (60%) patients. The syndromic rm-PCR detected at least one bacteria in 132 (83%) episodes. Based on the results of the rm-PCR, the multidisciplinary committee proposed a modification of the empirical therapy in 123 (77%) pneumonia episodes. The modification was a de-escalation in 63 (40%), an escalation in 35 (22%), and undetermined in 25 (16%) patients. In microbiologically documented episodes (n = 95), the rm-PCR increased appropriateness of the empirical therapy to 83 (87%), as compared to 73 (77%) in routine care. CONCLUSIONS: Use of a syndromic rm-PCR test has the potential to reduce unnecessary antimicrobial exposure and increase the appropriateness of empirical antibiotic therapy in adult patients with pneumonia. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359443/ doi: 10.1186/s13054-020-03114-y id: cord-272419-y3ebt4jm author: Monari, Caterina title: A Focus on the Nowadays Potential Antiviral Strategies in Early Phase of Coronavirus Disease 2019 (Covid-19): A Narrative Review date: 2020-08-09 words: 6476.0 sentences: 318.0 pages: flesch: 46.0 cache: ./cache/cord-272419-y3ebt4jm.txt txt: ./txt/cord-272419-y3ebt4jm.txt summary: Possible inhibition of SARS-CoV-2 3-chymotrisyn-like (3CL)-protease and papain-like protease Lopinavir is excreted in the gastrointestinal (GI) tract, and thus coronavirus-infected enterocytes might be exposed to higher concentrations of the drug LPV/r tab 200/50 mg: 2 tab BID LPV/r oral sol 80/20 mg: 5 mL BID DRV/cobi tab 800/150 mg: 1 tab QD Gastrointestinal: diarrhea, nausea, vomiting, increased amylase, lipase, total cholesterol and triglycerides (risk factor for pancreatitis) Hepatotoxicity: increasing in GGT, AST, ALT, total bilirubin, hepatitis Cardiological: QT-and PR-interval prolongation, hypertension, bradyarrhytmias; torsade de pointes have been reported in patients treated with LPV/r Metabolical: hyperglycemia and diabetes mellitus, increased uric acid Recently, a randomized, controlled, open-label trial comparing the efficacy of LPV/r versus standard of care was conducted in 199 hospitalized adult patients with severe COVID-19: no significant difference between the two groups neither in the time of clinical improvement (hazard ratio [HR] 1.31; 95% CI 0.95-1.80; p 0.09), nor in the 28-day mortality rate (19.2% versus 25.0%; 95% CI −17.3 to 5.7) was observed [40] . abstract: Background: The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the related disease (COVID-19) has rapidly spread to a pandemic proportion, increasing the demands on health systems for the containment and management of COVID-19. Nowadays, one of the critical issues still to be pointed out regards COVID-19 treatment regimens and timing: which drug, in which phase, for how long? Methods: Our narrative review, developed using MEDLINE and EMBASE, summarizes the main evidences in favor or against the current proposed treatment regimens for COVID-19, with a particular focus on antiviral agents. Results: Although many agents have been proposed as possible treatment, to date, any of the potential drugs against SARS-CoV-2 has shown to be safe and effective for treating COVID-19. Despite the lack of definitive evidence, remdesivir remains the only antiviral with encouraging effects in hospitalized patients with COVID-19. Conclusions: In such a complex moment of global health emergency, it is hard to demand scientific evidence. Nevertheless, randomized clinical trials aiming to identify effective and safe drugs against SARS-CoV-2 infection are urgently needed in order to confirm or reject the currently available evidence. url: https://www.ncbi.nlm.nih.gov/pubmed/32784922/ doi: 10.3390/life10080146 id: cord-323225-ou7pppum author: Mondal, R. N. title: Socio-demographic, clinical, hospital admission and oxygen requirement characteristics of COVID-19 patients of Bangladesh date: 2020-08-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Background: Clinical presentation hospital admission and outcome of COVID-19 pandemic are different from one country to another. So every country should have their own data regarding COVID-19. Subjects and Methods: This was an online cross-sectional survey carried out in RT-PCR positive COVID-19 adult patient. A preformed questionnaire adapted in Google form and circulated through online to collect data. Informed consent was ensured before participation in this study. Results: We have studied of 305 RT-PCR positive COVID-19 patients mean age was 36.32(+/-12.369) years with male predominance and majority were doctor 46.9%. 48.8% of the patients family members affected along with them. After COVID-19 pandemic 31.7% did not go out of their house. For prevention (72.4%)of the patients used mask and 38.8% used hand gloves during outing. 28.7% reported to be affected while working in hospital 21.8%were affected in their office. Fever (80.1%) cough (57.7%) pain in throat (50.8%) rhinitis (45.9%) and loss of smell (45%) and taste sensation (45.6%) were the most common symptoms. Sample was given average 3 (+/- 3.384) days after onset of the symptoms and report was delivered average 4.57 days after giving sample. After getting result 32.1% of the patients seek treatment in telemedicine and 23% directly consulted in Government hospital only 2% reported to be treated by the Government designated telephone number. 73.1% of the patient took both steam inhalation and warm water gargling. Paracetamol and antihistamine was the most commonly use drugs 69.8% and 71.5% respectively besides 47.5% took ivermectin 41.6% took azithromycin 35.1% steroid 34.8% took doxycyclin and 21.6% hydroxychloroquine. Among the patients only 20.3% needed hospital admission. The patients admitted in hospital average 5 (+/-3.922) days after onset of symptoms and hospital staying was 9.2 days (average). Breathless (54.83%) was the major cause of hospital admission and 19.35% patients admitted due to fear. 14% patients needed oxygen and average duration of oxygen was 4.84 days. 81.3% patients has taken oxygen in hospital and 18.8% at their home. Among the patient 2.2% needed ICU and artificial ventilation needed for 1.1% patients. The patients recovered after 17.74 days (average) from the onset of symptom. COVID-19 became negative (RT-PCR) at15th day from onset of symptom. 91.8%) were in mental stress to become the cause of infection spread to other family members 20.7%) reported that they were anxious that they would not get oxygen or ICU if required and 27.9% were suffering from fear of death. Weakness was the most common post disease symptom in 57.4% cases. Average time required for coming back to normal life was 21.59 days (+/-7.901) ranging a wide range from 5 to 60 days. Conclusion: COVID-19 patients were mostly male health worker. Fever cough pain in throat were most common symptoms. Hospital admission required in only one-fifth cases and ICU required for only 2% patients. Weakness was the most common post disease symptom. Keywords: COVID Bangladesh oxygen ivermectin Correspondence Dr. Ratindra Nath Mondal President Society of General Physician Founder-Daktarkhana (GP center) Rangpur Bangladesh Email dr.ratinmondal@gmail.com. url: http://medrxiv.org/cgi/content/short/2020.08.14.20175018v1?rss=1 doi: 10.1101/2020.08.14.20175018 id: cord-292350-cmrtg91a author: Mondal, Samhati title: Thromboembolic disease in COVID-19 patients: A brief narrative review date: 2020-09-14 words: 4000.0 sentences: 207.0 pages: flesch: 29.0 cache: ./cache/cord-292350-cmrtg91a.txt txt: ./txt/cord-292350-cmrtg91a.txt summary: Table 1 & 2 summarize the various thrombotic complications noted in COVID-19 patients as published as of June 6 th , 2020 obtained by a literature search on PubMed and EMBASE using combinations of the following MeSH terms: COVID-19, SARS-COV2, novel corona virus, thrombosis, thromboembolic complications, pulmonary embolism. Clinical signs and symptoms of thrombosis such as cutaneous manifestations ("COVID toe") [84] , overt line thrombosis, arterial or venous clots, unexplained increase in oxygen requirement, or organ dysfunction should raise suspicion and prompt further investigation and/or discussion about therapeutic intervention [7] As new information becomes available, it appears increasingly important to routinely monitor platelet count, PT/aPTT, d-dimer, and fibrinogen to assist in anticipating and managing thrombotic complications. ICU patients positive for COVID-19 with elevated d-dimer levels and/or clinico-radiological suspicion for thrombosis as noted above should be considered for therapeutic anticoagulation only after careful assessment of their bleeding risk. abstract: Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and is seen in a multitude of organ systems ranging from cutaneous thrombosis to pulmonary embolism, stroke or coronary thrombosis sometimes with catastrophic outcomes. Evidence points towards a key role of thromboembolism, hypercoagulability and over production of proinflammatory cytokines mimicking a “cytokine storm” which leads to multiorgan failure. This brief narrative review highlights the pathophysiology and risk factors of thromboembolic disease and provides a framework for management of anticoagulation based on the current evidence. url: https://doi.org/10.1186/s40560-020-00483-y doi: 10.1186/s40560-020-00483-y id: cord-287117-3v9nyagt author: Monteagudo, Luke Adam title: Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome date: 2020-04-21 words: 4638.0 sentences: 266.0 pages: flesch: 47.0 cache: ./cache/cord-287117-3v9nyagt.txt txt: ./txt/cord-287117-3v9nyagt.txt summary: OBJECTIVE: The objective of this study was to report the benefit of a therapeutic approach consisting of intravenous (IV) continuous anakinra (recombinant human interleukin‐1 receptor antagonist) infusions in treating severely ill adult patients with secondary hemophagocytic lymphohistiocytosis or macrophage activation syndrome (MAS). The diagnosis of MAS was made using the HLH-2004 criteria, which require five of the eight following findings: fever greater than or equal to 38.5°C, splenomegaly; peripheral blood cytopenias (at least two of the following: hemoglobin level less than 9 g/dl, platelet count less than 100 000 cells per μl, and absolute neutrophil count less than 1000 cells per μl); hypertriglyceridemia (fasting triglyceride level greater than 265 mg/dl) and/or hypofibrinogenemia (fibrinogen level less than 150 mg/dl); hemophagocytosis in the bone marrow, spleen, lymph node, or liver; low or absent natural killer cell activity; ferritin level greater than 500 ng/ml; and elevated soluble CD25 levels (sIL-2Rα) two SDs above age-adjusted laboratory-specific norms. abstract: OBJECTIVE: The objective of this study was to report the benefit of a therapeutic approach consisting of intravenous (IV) continuous anakinra (recombinant human interleukin‐1 receptor antagonist) infusions in treating severely ill adult patients with secondary hemophagocytic lymphohistiocytosis or macrophage activation syndrome (MAS). METHODS: A retrospective chart review of five patients treated at Regions Hospital from 2016 to 2019 was conducted. Demographic, clinical, and laboratory characteristics and outcomes were recorded. RESULTS: Continuous IV anakinra infusions up to 2400 mg/d resulted in rapid serologic, then clinical response in 4 of 5 severely ill patients who were refractory to all other therapies, including subcutaneous anakinra. Subsequently, 3 of 5 patients have been maintained on anakinra or canakinumab, with no recurrence of MAS. CONCLUSION: Continuous infusion of IV anakinra may result in rapid serologic and subsequent clinical improvement in adult patients with MAS. This method for treating cytokine storm should be considered in the current COVID‐19 pandemic in the subgroup of patients with severe disease who have a cytokine storm presentation. url: https://doi.org/10.1002/acr2.11135 doi: 10.1002/acr2.11135 id: cord-341531-w788qwya author: Montero Feijoo, A. title: Practical recommendations for the perioperative management of patients with suspicion or serious infection by coronavirus SARS-CoV date: 2020-05-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract In December 2019, the Wuhan Municipal Health and health Commission (Hubei Province, China) reported a series of cases of pneumonia of unknown aetiology. On January 7, 2020, the Chinese authorities identified as a causative agent of the outbreak a new type of virus of the Coronaviridiae family, called SARS-CoV-2. Since then, thounsands of cases have been reported with global dissemination. Infections in humans cause a broad clinical spectrum ranging from mild upper respiratory tract infection, to severe acute respiratory distress syndrome and sepsis. There is not specific treatment for SARS-CoV-2, which is why the fundamental aspects are to establish adequate prevention measures and support treatment and management of complications. url: https://www.sciencedirect.com/science/article/pii/S2341192920300597 doi: 10.1016/j.redare.2020.03.002 id: cord-327165-vlyfbiem author: Montorfano, Lisandro title: Colorectal surgery obesity-related morbidity during COVID-19 date: 2020-07-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Tocilizumab, a monoclonal antiinterluekin-6 receptor antibody, has been empirically used in the treatment of cytokine release syndrome associated with severe coronavirus disease 2019 infections. The efficacy and safety of these medications for these patients is unknown. The purpose of this report was to present a case of acute large bowel perforation in a morbidly obese patient with coronavirus disease 2019 pneumonia who received empiric Tocilizumab. This case report analyzes the risks of acute large bowel perforation after using this medication empirically and discusses the appropriate management of this adverse event. url: https://www.sciencedirect.com/science/article/pii/S1550728920303312 doi: 10.1016/j.soard.2020.06.011 id: cord-268049-7xqln70d author: Montrief, Tim title: COVID-19 respiratory support in the emergency department setting date: 2020-08-08 words: 5197.0 sentences: 337.0 pages: flesch: 45.0 cache: ./cache/cord-268049-7xqln70d.txt txt: ./txt/cord-268049-7xqln70d.txt summary: DISCUSSION: Patients presenting with SARS-CoV-2 infection are at high risk for acute respiratory failure requiring airway management. [29] [30] [31] [32] Based on currently available evidence, the WHO states that "HFNC and NIV systems with good interface fitting do not create widespread dispersion of exhaled air and therefore should be associated with [a] low risk of airborne transmission." 15 The risk of respiratory pathogen transmission when using HFNC is subject to a variety of factors, including the duration of support, maximal flow rate, patient sneezing or coughing, cannula fit, and patient cooperation. 35 Many guidelines, including those by Australian and New Zealand Intensive Care Society (ANZICS), the WHO, and the Surviving Sepsis Campaign recommend the use of HFNC in COVID-19 patients presenting with acute hypoxemic respiratory failure unresponsive to conventional oxygen therapy. 20 Notably, the SCCM guidelines on the management of critically ill patients with COVID-19 recommend "a trial of NIV with close monitoring and shortinterval assessment for worsening of respiratory failure" if HFNC is not available and there is no urgent indication for intubation. abstract: INTRODUCTION: Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19), may result in severe complications, multiorgan dysfunction, acute respiratory failure, and death. SARS-CoV-2 is highly contagious and places healthcare workers at significant risk, especially during aerosol-generating procedures, including airway management. OBJECTIVE: This narrative review outlines the underlying respiratory pathophysiology of patients with COVID-19 and discusses approaches to airway management in the emergency department (ED) based on current literature. DISCUSSION: Patients presenting with SARS-CoV-2 infection are at high risk for acute respiratory failure requiring airway management. Among hospitalized patients, 10–20% require intensive care unit admission, and 3–10% require intubation and mechanical ventilation. While providing respiratory support for these patients, proper infection control measures, including adherence to personal protective equipment policies, are necessary to prevent nosocomial transmission to healthcare workers. A structured approach to respiratory failure in these patients includes the use of exogenous oxygen via nasal cannula or non-rebreather, as well as titrated high-flow nasal cannula and non-invasive ventilation. This review offers several guiding principles and resources designed to be adapted in conjunction with local workplace policies for patients requiring endotracheal intubation. CONCLUSIONS: While the fundamental principles of acute respiratory failure management are similar between COVID-19 and non-COVID-19 patients, there are some notable differences, including a focus on provider safety. This review provides an approach to airway management and respiratory support in the patient with COVID-19. url: https://doi.org/10.1016/j.ajem.2020.08.001 doi: 10.1016/j.ajem.2020.08.001 id: cord-282724-zzkqb0u2 author: Moore, Jason H. title: Ideas for how informaticians can get involved with COVID-19 research date: 2020-05-12 words: 7588.0 sentences: 315.0 pages: flesch: 33.0 cache: ./cache/cord-282724-zzkqb0u2.txt txt: ./txt/cord-282724-zzkqb0u2.txt summary: Some key considerations and targets of research include: (1) feature engineering, transforming raw data into features (i.e. variables) that ML can better utilize to represent the problem/target outcome, (2) feature selection, applying expert domain knowledge, statistical methods, and/or ML methods to remove ''irrelevant'' features from consideration and improve downstream modeling, (3) data harmonization, allowing for the integration of data collected at different sites/institutions, (4) handling different outcomes and related challenges, e.g. binary classification, multi-class, quantitative phenotypes, class imbalance, temporal data, multi-labeled data, censored data, and the use of appropriate evaluation metrics, (5) ML algorithm selection for a given problem can be a challenge in itself, thus strategies to integrate the predictions of multiple machine learners as an ensemble are likely to be important, (6) ML modeling pipeline assembly, including critical considerations such as hyper-parameter optimization, accounting for overfitting, and clinical interpretability of trained models, and (7) considering and accounting for covariates as well as sources of bias in data collection, study design, and application of ML tools in order to avoid drawing conclusions based on spurious correlations. abstract: The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on population health and wellbeing. Biomedical informatics is central to COVID-19 research efforts and for the delivery of healthcare for COVID-19 patients. Critical to this effort is the participation of informaticians who typically work on other basic science or clinical problems. The goal of this editorial is to highlight some examples of COVID-19 research areas that could benefit from informatics expertise. Each research idea summarizes the COVID-19 application area, followed by an informatics methodology, approach, or technology that could make a contribution. It is our hope that this piece will motivate and make it easy for some informaticians to adopt COVID-19 research projects. url: https://www.ncbi.nlm.nih.gov/pubmed/32419848/ doi: 10.1186/s13040-020-00213-y id: cord-283267-72wrzw09 author: Moores, Lisa K. title: Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report date: 2020-06-02 words: 8241.0 sentences: 474.0 pages: flesch: 40.0 cache: ./cache/cord-283267-72wrzw09.txt txt: ./txt/cord-283267-72wrzw09.txt summary: The recognition of the coagulopathy with COVID-19, and the early evidence that suggests that thrombosis in these patients is higher than that seen in similarly ill hospitalized patients with other respiratory infections has led to the urgent need for practical guidance regarding prevention, diagnosis, and treatment of VTE. 19 Pooled risk estimates for benefits and harms of anticoagulant thromboprophylaxis in critically ill medical patients without COVID-19 differ across meta-analyses, 19, 22, 46 but practice guidelines consistently recommend anticoagulant thromboprophylaxis with LMWH (or unfractionated heparin [UFH]) over no such therapy. Our literature search did not identify any randomized trials assessing the efficacy and safety of anticoagulants for the treatment of acute VTE in hospitalized or critically ill COVID-19 patients. Our literature search did not identify any randomized trials or prospective cohort studies assessing the efficacy or safety of any thrombolytic therapies for the management of critically ill patients with COVID-19 without objective evidence of VTE and VTE-associated hypotension. abstract: Abstract: Background Emerging evidence shows that severe COVID-19 can be complicated by a significant coagulopathy, that likely manifests in the form of both microthrombosis and venous thromboembolism (VTE). This recognition has led to the urgent need for practical guidance regarding prevention, diagnosis, and treatment of VTE. Methods A group of approved panelists developed key clinical questions by using the PICO (population, intervention, comparator, and outcome) format that addressed urgent clinical questions regarding the prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19. MEDLINE (via PubMed or Ovid), Embase and Cochrane Controlled Register of Trials were systematically searched for relevant literature and references were screened for inclusion. Validated evaluation tools were used to grade the level of evidence to support each recommendation. When evidence did not exist, guidance was developed based on consensus using the modified Delphi process. Results The systematic review and critical analysis of the literature based on13 PICO questions resulted in 22 statements. Very little evidence exists in the COVID-19 population. The panel thus used expert consensus and existing evidence-based guidelines to craft the guidance statements. Conclusions The evidence on the optimal strategies to prevent, diagnose, and treat venous thromboembolism in patients with COVID-19 is sparse, but rapidly evolving. url: https://www.ncbi.nlm.nih.gov/pubmed/32502594/ doi: 10.1016/j.chest.2020.05.559 id: cord-307160-1vz0gw1w author: Morais-Almeida, Mário title: COVID-19, asthma, and biologic therapies: What we need to know date: 2020-05-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Managing patients with severe asthma during the coronavirus pandemic COVID-19 is a challenge. Authorities and physicians are still learning how COVID-19 affects people with underlying diseases, and severe asthma is not an exception. Unless relevant data emerges that changes our understanding of the relative safety of medications indicated in patients with asthma during this pandemic, clinicians must follow the recommendations of current evidence-based guidelines, preventing loss of control and exacerbations. Also, with the absence of data that would indicate any potential harm, current advice is to continue the administration of biologic agents during the COVID-19 pandemic in patients with asthma for whom such agents are clearly indicated and have been effective. For the patients with severe asthma infected by SARS-CoV-2, the decision to maintain or postpone biologic therapy until the patient recovers should be a case-by-case based decision supported by a multidisciplinary team. A registry of cases of COVID-19 in patients with severe asthma, including those treated with biologics, will help to address a clinical challenge where we have more questions than answers. url: https://www.sciencedirect.com/science/article/pii/S1939455120300296?v=s5 doi: 10.1016/j.waojou.2020.100126 id: cord-331604-jf6ybip5 author: Moratto, Daniele title: Flow Cytometry Identifies Risk Factors and Dynamic Changes in Patients with COVID-19 date: 2020-06-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32594342/ doi: 10.1007/s10875-020-00806-6 id: cord-291265-qmylxndp author: Moravvej, Zahra title: COVID-19 pandemic: Ophthalmic practice and precautions in a tertiary eye hospital in Iran date: 2020-04-23 words: 1219.0 sentences: 84.0 pages: flesch: 50.0 cache: ./cache/cord-291265-qmylxndp.txt txt: ./txt/cord-291265-qmylxndp.txt summary: title: COVID-19 pandemic: Ophthalmic practice and precautions in a tertiary eye hospital in Iran 7 Here, we address the prevention strategies employed against COVID-19 according to assessments of infection control experts and ophthalmologists, in Amiralmomenin Hospital a tertiary referral eye hospital in Guilan, Iran. To avoid redundant visits to the hospital, patients who were managed in an outpatient setting were contacted via phone by eye-care professionals at appropriate intervals. Environmental surfaces frequently touched by staff and patients, such as light switches, door knobs, and nursing stations were cleaned according to Centers for Disease Control and Prevention (CDC) recommendations. The personal protective equipment for the eye-care nursing staff, ophthalmology residents, and attending eye surgeons included Latex gloves, eye protection (goggles or face shields), a surgical-style face mask, a long-sleeved fluid-resistant gown, and disposable shoe covers. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection Interim infection prevention and control recommendations for patients with suspected or confirmed coronavirus disease 2019 (COVID-19) in healthcare settings abstract: The coronavirus disease 2019 (COVID-19) has currently caused a global health threat. Ophthalmic care settings pose a risk of cross-infection. The preventive strategy regarding ophthalmic practice in response to the outbreak is discussed. This is the first report form a tertiary eye hospital in Iran and second of its kind worldwide. url: https://www.ncbi.nlm.nih.gov/pubmed/32321611/ doi: 10.1017/ice.2020.164 id: cord-313239-0gl43af5 author: Moreno, Courtney C. title: CT colonography’s role in the COVID-19 pandemic: a safe(r), socially distanced total colon examination date: 2020-08-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To describe the favorable procedural profile of CT colonography (CTC) during the COVID-19 pandemic. CONCLUSION: Postponement of cancer screening due to COVID-19 has resulted in a backlog of individuals needing to undergo structural examination of the colon. The experience during the initial COVID-19 surge with urgent evaluation of the colon for transplant patients prior to transplant suggests that CTC can be done in a lower risk manner as compared to other structural examinations. The procedural profile of CTC is advantageous during this pandemic as maintaining social distancing and preserving healthcare supplies including PPE are of paramount importance. CTC is an important option to utilize in the screening armamentarium to allow effective screening of average risk asymptomatic individuals in the COVID-19 era. url: https://doi.org/10.1007/s00261-020-02674-5 doi: 10.1007/s00261-020-02674-5 id: cord-005808-w0763esk author: Moreno, Gerard title: Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study date: 2018-08-03 words: 5146.0 sentences: 311.0 pages: flesch: 41.0 cache: ./cache/cord-005808-w0763esk.txt txt: ./txt/cord-005808-w0763esk.txt summary: CONCLUSION: Administration of corticosteroids in patients with severe influenza pneumonia is associated with increased ICU mortality, and these agents should not be used as co-adjuvant therapy. Therefore, the aim of the present study was to identify the factors associated with corticosteroid use and its impact on intensive care unit (ICU) mortality using propensity score (PS) matching analysis in ICU patients with influenza pneumonia. Our results strongly suggest that administration of corticosteroids as co-adjuvant therapy to standard antiviral treatment in critically ill patients with severe influenza pneumonia is associated with increased ICU mortality. Three recent systematic reviews and meta-analyses [41] [42] [43] concluded that corticosteroid therapy is significantly associated with mortality, even in the subgroup of patients with influenza hospitalized in or outside the ICU. In a homogeneous group of critically ill patients with severe influenza pneumonia, after adequate adjustment by PS matching and competing risks, co-adjuvant corticosteroid therapy was significantly associated with increased ICU mortality. abstract: PURPOSE: To determine clinical predictors associated with corticosteroid administration and its association with ICU mortality in critically ill patients with severe influenza pneumonia. METHODS: Secondary analysis of a prospective cohort study of critically ill patients with confirmed influenza pneumonia admitted to 148 ICUs in Spain between June 2009 and April 2014. Patients who received corticosteroid treatment for causes other than viral pneumonia (e.g., refractory septic shock and asthma or chronic obstructive pulmonary disease [COPD] exacerbation) were excluded. Patients with corticosteroid therapy were compared with those without corticosteroid therapy. We use a propensity score (PS) matching analysis to reduce confounding factors. The primary outcome was ICU mortality. Cox proportional hazards and competing risks analysis was performed to assess the impact of corticosteroids on ICU mortality. RESULTS: A total of 1846 patients with primary influenza pneumonia were enrolled. Corticosteroids were administered in 604 (32.7%) patients, with methylprednisolone the most frequently used corticosteroid (578/604 [95.7%]). The median daily dose was equivalent to 80 mg of methylprednisolone (IQR 60–120) for a median duration of 7 days (IQR 5–10). Asthma, COPD, hematological disease, and the need for mechanical ventilation were independently associated with corticosteroid use. Crude ICU mortality was higher in patients who received corticosteroids (27.5%) than in patients who did not receive corticosteroids (18.8%, p < 0.001). After PS matching, corticosteroid use was associated with ICU mortality in the Cox (HR = 1.32 [95% CI 1.08–1.60], p < 0.006) and competing risks analysis (SHR = 1.37 [95% CI 1.12–1.68], p = 0.001). CONCLUSION: Administration of corticosteroids in patients with severe influenza pneumonia is associated with increased ICU mortality, and these agents should not be used as co-adjuvant therapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-018-5332-4) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095489/ doi: 10.1007/s00134-018-5332-4 id: cord-031130-xvkyt3l3 author: Moreno-Duarte, Ingrid title: Heparin Induced Thrombocytopenia for the Perioperative and Critical Care Clinician date: 2020-08-29 words: 6021.0 sentences: 317.0 pages: flesch: 34.0 cache: ./cache/cord-031130-xvkyt3l3.txt txt: ./txt/cord-031130-xvkyt3l3.txt summary: RECENT FINDINGS: Heparin-induced thrombocytopenia (HIT) occurs more frequently in surgical patients compared with medical patients due to the inflammatory release of platelet factor 4 and perioperative heparin exposure. Heparinoid exposure by syringe flush, subcutaneous prophylaxis, or therapeutic anticoagulation is common in the operative room (OR) and ICU environments [5] .Only a fraction of those with low platelet counts will develop HIT, which presents in approximately 0.3-0.5% of critically ill patients exposed to heparin [6] . Although HIT is less frequent in cardiac surgical patients compared with orthopedic patients, cardiac surgical patients have a higher frequency of HIT immunization (positive antibody formation) [15] , potentially due to the high intraoperative UFH doses required for anticoagulation on cardiopulmonary bypass [7, 17] . Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells abstract: PURPOSE OF REVIEW: This review will illustrate the importance of heparin-induced thrombocytopenia in the intraoperative and critical care settings. RECENT FINDINGS: Heparin-induced thrombocytopenia (HIT) occurs more frequently in surgical patients compared with medical patients due to the inflammatory release of platelet factor 4 and perioperative heparin exposure. Recognition of this disease requires a high index of suspicion. Diagnostic tools and therapeutic strategies have been expanded and refined in recent years. SUMMARY: HIT is a condition where antibodies against the heparin/platelet factor 4 complex interact with platelet receptors to promote platelet activation, aggregation, and thrombus formation. Our review will focus on intraoperative and postoperative considerations related to HIT to help the clinician better manage this rare but often devastating hypercoagulable disease process. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455512/ doi: 10.1007/s40140-020-00405-6 id: cord-017252-88b3preq author: Morgan, Carrie I. title: Pneumonia date: 2014-02-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Respiratory diagnoses continue to make up a large number of admissions to the pediatric intensive care unit (PICU), most notably lower respiratory infections including pneumonia. This chapter will focus on pediatric community-acquired pneumonia (CAP), immunocompromised pneumonia, and aspiration pneumonia. The pathogenesis for developing pneumonia varies; it can occur by direct inhalation of infectious particles in the air or aspiration, direct extension from the upper airways, and hematogenous spread. There are multiple levels of defense against pathogen invasion including anatomic barriers, as well as innate and adaptive immunity, which may be compromised in PICU patients. The etiologies of pediatric pneumonia vary depending on age, host condition, and environmental factors like time of year and location. Viruses remain the most common form of lower respiratory tract infection in children, especially in neonates. Community-acquired bacterial pneumonia continues to be most prevalent in younger children as well, most often affecting children less than 5 years of age who are otherwise healthy. Despite immunizations and public health initiatives, the most common bacterial causes of CAP have remained largely unchanged over the last several decades and include: Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae (including non-typable strains) and Moraxella catarrhalis. Pulmonary infection in an immunocompromised host provides a much broader differential and must be aggressively treated without delay. This chapter will also address various imaging modalities and typical findings with pediatric pneumonia. Methods for pathogen identification are broad and range from non-specific markers of illness to invasive techniques for culture. The mainstay of therapy continues to be antibiotics tailored to the patient and presumed etiology; more novel therapies may include corticosteroids or macrolide antibiotics for immune modulation. In those patients with pneumonia with effusion or empyema, drainage therapies with thoracostomy tubes or a VATS procedure may be indicated. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121765/ doi: 10.1007/978-1-4471-6356-5_6 id: cord-337995-z4rcczki author: Moris, Dimitrios title: Kidney Transplant Recipients Infected By COVID‐19: Review of the Initial Published Experience date: 2020-07-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There is an accumulating body of literature surrounding the impact of COVID‐19 infection in solid organ transplant recipients. The aim of this review is to summarize the existing literature specifically in kidney transplant (KTx) recipients, with an emphasis on the epidemiology, clinical presentation, laboratory findings, post‐operative outcomes and therapeutic strategies currently employed. We identified thirty‐seven studies published between January 1(st) 2020 to June 10(th) 2020 that were included in our analysis. As is reported in the general population, there is a wide variation in COVID‐19 presentation among KTx patients, ranging from asymptomatic to life‐threatening end‐organ failure. The most common symptoms are predominantly respiratory and associated with fever. On lab evaluation, many patients present with lymphopenia and increased CRP, which are both associated with inferior outcomes. The majority of patients with severe symptoms have been managed with reduction of immunosuppression, including decreased doses of CNIs and withdrawal of MMF. Lastly, although there is no high‐level data supporting the use of immunomodulatory drugs, such as IL‐6 inhibitors, early experiences have suggested these drugs may improve outcomes in KTx patients with severe COVID‐19. url: https://doi.org/10.1111/tid.13426 doi: 10.1111/tid.13426 id: cord-270876-kul6bs3w author: Morris, Nathaniel P. title: Virtual Visits and the Future of No-Shows date: 2020-06-08 words: 1301.0 sentences: 71.0 pages: flesch: 53.0 cache: ./cache/cord-270876-kul6bs3w.txt txt: ./txt/cord-270876-kul6bs3w.txt summary: 2 By allowing patients to remotely attend appointments through audiovisual applications, virtual visits bring promise for decreasing outpatient no-shows. Patients can attend virtual visits from anywhere, including their homes, their workplaces, or even their parked cars, decreasing the burdens of making it to in-person appointments. In the study of general surgery outpatients from 2018, 123 (55%) of 223 patients reported they would prefer in-person appointments over virtual ones, even when accounting for the time and cost of coming to in-person appointments. 2 Patients and clinicians might struggle with setting up the technology needed for virtual visits, which might waste time and resources. For example, a 2019 study from Canada of home virtual visits for 75 patients at a stroke prevention clinic reported a no-show rate of 2 (3%) out of 81 appointments, but the study did not include comparisons of no-show rates for in-person clinic visits. Why do patients miss their appointments at primary care clinics? abstract: nan url: https://doi.org/10.1007/s11606-020-05948-2 doi: 10.1007/s11606-020-05948-2 id: cord-254357-5s84kimn author: Morse, Alan R title: Decreasing Avoidable Vision Loss: Identifying Antecedents of Adherence date: 2020-11-02 words: 2937.0 sentences: 144.0 pages: flesch: 34.0 cache: ./cache/cord-254357-5s84kimn.txt txt: ./txt/cord-254357-5s84kimn.txt summary: Adherence to medication treatment protocols and active participation by individuals in their medical care are important for all patients, but especially for those with chronic conditions such as vision loss. 13 Lack of patient-physician communication can impair treatment effectiveness and result in vision loss since as many as 30% of all prescriptions are never filled 14 and within 6 months, an estimated 50% of prescriptions that are filled are no longer being used; 15 whether cost is a factor in such cases is unknown. 23, 24 For patients with AMD or diabetic eye disease, failure keeps scheduled appointments for intravitreal injections or monitoring undermines treatment efficacy, impairs successful patient outcomes and results in loss of vision that might have been avoided. Active participation by individuals in their medical care is important for all patients, but especially for those with chronic conditions such as vision loss. abstract: Adherence to medication treatment protocols and active participation by individuals in their medical care are important for all patients, but especially for those with chronic conditions such as vision loss. Adherence is crucial for decreasing avoidable vision loss. Failure to take medications as prescribed and keep scheduled appointments reduces treatment effectiveness, increases complications and results in poorer outcomes. Reasons for nonadherence vary by diagnosis and include not understanding the importance of adherence, low health literacy, lack of adequate self-efficacy, low level of activation and behavioral issues including depression. Patients may lack information about their condition and its prognosis, available treatment alternatives, and other essential information such as how to monitor their eye condition, what to do if vision deteriorates and how to get needed community-based help. Each of these factors impedes patients’ ability to engage with their physician and participate in their own care. The ability of individuals with vision loss to actively and effectively manage their health care, ie, activation, has been understudied. When patients are involved with their own care, their care experience, and most importantly, their outcomes, are improved. Identifying antecedents of adherence may help provide disease- and patient-specific pathways to reduce avoidable vision loss. url: https://www.ncbi.nlm.nih.gov/pubmed/33173271/ doi: 10.2147/opth.s278627 id: cord-274250-95yzt1gj author: Mortaz, Esmaeil title: Silent hypoxia: higher NO in red blood cells of COVID-19 patients date: 2020-10-16 words: 2716.0 sentences: 159.0 pages: flesch: 48.0 cache: ./cache/cord-274250-95yzt1gj.txt txt: ./txt/cord-274250-95yzt1gj.txt summary: The major clinical feature of severe COVID-19 requiring ventilation is acute respiratory distress syndrome (ARDS) with multi-functional failure as a result of a cytokine storm with increased serum levels of cytokines. The kinetics and allosteric regulation of Hb nitrosylation by oxygen and pH are consistent with the physiologic mechanisms that modulate tissue blood flow, namely acidosis and hypoxemia and tissue hypoxia leads to NO generation by the RBC via SNO-protein transfer of NO activity [12] . To examine the hypothesis that NO is important in regulating vasodilation during hypoxia in these subjects we studied intracellular levels of NO in COVID-19 patients. In our study, intracellular RBC NO of COVID-19 patients is significantly higher than in healthy controls and this may enable the release of oxygen to tissues resulting in the clinical manifestation of silent hypoxia in these patients. abstract: BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has spread to almost 100 countries, infected over 31 M patients and resulted in 961 K deaths worldwide as of 21st September 2020. The major clinical feature of severe COVID-19 requiring ventilation is acute respiratory distress syndrome (ARDS) with multi-functional failure as a result of a cytokine storm with increased serum levels of cytokines. The pathogenesis of the respiratory failure in COVID-19 is yet unknown, but diffuse alveolar damage with interstitial thickening leading to compromised gas exchange is a plausible mechanism. Hypoxia is seen in the COVID-19 patients, however, patients present with a distinct phenotype. Intracellular levels of nitric oxide (NO) play an important role in the vasodilation of small vessels. To elucidate the intracellular levels of NO inside of RBCs in COVID-19 patients compared with that of healthy control subjects. METHODS: We recruited 14 COVID-19 infected cases who had pulmonary involvement of their disease, 4 non-COVID-19 healthy controls (without pulmonary involvement and were not hypoxic) and 2 hypoxic non-COVID-19 patients subjects who presented at the Masih Daneshvari Hospital of Tehran, Iran between March–May 2020. Whole blood samples were harvested from patients and intracellular NO levels in 1 × 10(6) red blood cells (RBC) was measured by DAF staining using flow cytometry (FACS Calibour, BD, CA, USA). RESULTS: The Mean florescent of intensity for NO was significantly enhanced in COVID-19 patients compared with healthy control subjects (P ≤ 0.05). As a further control for whether hypoxia induced this higher intracellular NO, we evaluated the levels of NO inside RBC of hypoxic patients. No significant differences in NO levels were seen between the hypoxic and non-hypoxic control group. CONCLUSIONS: This pilot study demonstrates increased levels of intracellular NO in RBCs from COVID-19 patients. Future multi-centre studies should examine whether this is seen in a larger number of COVID-19 patients and whether NO therapy may be of use in these severe COVID-19 patients. url: https://doi.org/10.1186/s12890-020-01310-8 doi: 10.1186/s12890-020-01310-8 id: cord-308491-fc46k594 author: Mossa-Basha, Mahmud title: Policies and Guidelines for COVID-19 Preparedness: Experiences from the University of Washington date: 2020-04-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The Coronavirus Disease 2019 (COVID-19) pandemic initially presented in the United States in the greater Seattle area, and has rapidly progressed across the nation in the past 2 months, with the United States having the highest number of cases in the world. Radiology departments play a critical role in policy and guideline development both for the department and for the institutions, specifically in planning diagnostic screening, triage, and management of patients. In addition, radiology workflows, volumes and access must be optimized in preparation for the expected COVID-19 patient surges. This article discusses the processes that have been implemented at the University of Washington in managing the COVID-19 pandemic as well in preparing for patient surges, which may provide important guidance for other radiology departments who are in the early stages of preparation and management. url: https://doi.org/10.1148/radiol.2020201326 doi: 10.1148/radiol.2020201326 id: cord-336053-cjq7szcn author: Mottola, Filiberto Fausto title: Cardiovascular System in COVID-19: Simply a Viewer or a Leading Actor? date: 2020-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As of January 2020, a new pandemic has spread from Wuhan and caused thousands of deaths worldwide. Several studies have observed a relationship between coronavirus disease (COVID-19) infection and the cardiovascular system with the appearance of myocardial damage, myocarditis, pericarditis, heart failure and various arrhythmic manifestations, as well as an increase in thromboembolic risk. Cardiovascular manifestations have been highlighted especially in older and more fragile patients and in those with multiple cardiovascular risk factors such as cancer, diabetes, obesity and hypertension. In this review, we will examine the cardiac involvement associated with SARS-CoV-2 infection, focusing on the pathophysiological mechanism underlying manifestations and their clinical implication, taking into account the main scientific papers published to date. url: https://www.ncbi.nlm.nih.gov/pubmed/32867137/ doi: 10.3390/life10090165 id: cord-258278-25rhf91v author: Mowla, Ashkan title: Unusual Pattern of Arterial Macrothrombosis Causing Stroke in a Young Adult Recovered from COVID-19 date: 2020-09-25 words: 2052.0 sentences: 107.0 pages: flesch: 46.0 cache: ./cache/cord-258278-25rhf91v.txt txt: ./txt/cord-258278-25rhf91v.txt summary: Herein, we report a 36-year-old man with no significant past medical history who recently recovered from a mild COVID-19 infection and presented with unusual pattern of arterial macrothrombosis causing AIS. However, most of these patients had significant co-morbidities and established cardiovascular risk factors, making it difficult to confirm COVID-19 as the precipitating cause (3) While coagulopathy and vascular endothelial dysfunction have been widely reported as a consequence of severe COVID-19 infection, these findings are proposed to be directly related to the severity of the respiratory illness, (4) and the prevalence of this prothrombotic state among milder or asymptomatic cases is not yet established. Herein, we report an unusual pattern of arterial macrothrombosis presenting as large vessel stroke in a 36-year-old patient with no prior medical history (PMH) who had recently recovered from a mild COVID-19 infection. In conclusion, we report a young adult with no underlying comorbidities who recently recovered from COVID-19 infection and presented with AIS due to multicentric large vessel occlusion. abstract: Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Neurological manifestations related to COVID-19, including acute ischemic Stroke (AIS), have been reported in recent studies. In most of these, the patients are older, have multiple co-morbidities as risk factors for AIS and have developed a severe respiratory illness. Herein, we report a 36-year-old man with no significant past medical history who recently recovered from a mild COVID-19 infection and presented with unusual pattern of arterial macrothrombosis causing AIS. When the AIS happened, he had no COVID-19 related symptoms, had two negative screening tests for the infection and his chest CT was unremarkable. url: https://api.elsevier.com/content/article/pii/S1052305720307710 doi: 10.1016/j.jstrokecerebrovasdis.2020.105353 id: cord-347752-2ejnva4u author: Mrabti, Hind title: Cancer management challenge in a developing country in COVID-19 pandemic: reflection of a group of Moroccan oncologists date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Management of cancer patients during the COVID-19 pandemic is a worldwide challenge – in particular in developing countries where the risk of saturation of health facilities and intensive care beds must be minimized. The first case of COVID-19 was declared in Morocco on 2 March 2020, after which a panel of Moroccan experts, consisting of medical oncologists from universities and regional and private oncology centers, was promptly assembled to conduct a group reflection on cancer patient's management. The main objective is to protect the immunocompromised population from the risk of COVID-19, while maintaining an adequate management of cancer, which can quickly compromise their prognosis. Recommendations are provided according to each clinical situation: patients undergoing treatment, new cases, hospitalized patients, palliative care and surveillance. url: https://www.ncbi.nlm.nih.gov/pubmed/32583680/ doi: 10.2217/fon-2020-0450 id: cord-328384-jzfr2t3p author: Mudatsir, Mudatsir title: Predictors of COVID-19 severity: a systematic review and meta-analysis date: 2020-09-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: The unpredictability of the progression of coronavirus disease 2019 (COVID-19) may be attributed to the low precision of the tools used to predict the prognosis of this disease. Objective: To identify the predictors associated with poor clinical outcomes in patients with COVID-19. Methods: Relevant articles from PubMed, Embase, Cochrane, and Web of Science were searched and extracted as of April 5, 2020. Data of interest were collected and evaluated for their compatibility for the meta-analysis. Cumulative calculations to determine the correlation and effect estimates were performed using the Z test. Results: In total, 19 papers recording 1,934 mild and 1,644 severe cases of COVID-19 were included. Based on the initial evaluation, 62 potential risk factors were identified for the meta-analysis. Several comorbidities, including chronic respiratory disease, cardiovascular disease, diabetes mellitus, and hypertension were observed more frequent among patients with severe COVID-19 than with the mild ones. Compared to the mild form, severe COVID-19 was associated with symptoms such as dyspnea, anorexia, fatigue, increased respiratory rate, and high systolic blood pressure. Lower levels of lymphocytes and hemoglobin; elevated levels of leukocytes, aspartate aminotransferase, alanine aminotransferase, blood creatinine, blood urea nitrogen, high-sensitivity troponin, creatine kinase, high-sensitivity C-reactive protein, interleukin 6, D-dimer, ferritin, lactate dehydrogenase, and procalcitonin; and a high erythrocyte sedimentation rate were also associated with severe COVID-19. Conclusion: More than 30 risk factors are associated with a higher risk of severe COVID-19. These may serve as useful baseline parameters in the development of prediction tools for COVID-19 prognosis. url: https://doi.org/10.12688/f1000research.26186.1 doi: 10.12688/f1000research.26186.1 id: cord-326185-gjte739i author: Mukherjee, Pratik title: Adaptability and responsiveness: keys to operational measures in a regional hospital radiology department during the current COVID-19 pandemic date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The rapid and mostly uncontrolled spread of the coronavirus disease 2019 pandemic over the past 4 months has overwhelmed many healthcare systems worldwide. In Singapore, while our public healthcare institutions were considered well prepared due to our prior experience with the SARS outbreak, there was an unexpected surge of infected patients over the recent 2 months to deal with. We describe our radiology department’s experience in modifying operational practices and implementing strict infection control measures aimed at minimizing disease transmission and mitigating the potential impact of possible staff infection. From the perspective of serving a medium-sized regional hospital and limited by physical and manpower constraints, our radiology department had to adapt quickly and modify our initial responses and practices as the disease scenario changed. We have also enumerated some guidelines for planning future radiology departments. url: https://doi.org/10.1259/bjro.20200017 doi: 10.1259/bjro.20200017 id: cord-324859-0yuhb5dl author: Mulchandani, Rubina title: Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis date: 2020-11-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The coronavirus pandemic has affected more than 20 million people so far. Elevated cytokines and suppressed immune responses have been hypothesized to set off a cytokine storm, contributing to ARDS, multiple‐organ failure and, in the most severe cases, death. We aimed to quantify the differences in the circulating levels of major inflammatory and immunological markers between severe and nonsevere COVID‐19 patients. METHODS: Relevant studies were identified from PubMed, EMBASE, Web of Science, SCOPUS and preprint servers. Risk of bias was assessed for each study, using appropriate checklists. All studies were described qualitatively and a subset was included in the meta‐analysis, using forest plots. RESULTS: Based on 23 studies, mean cytokine levels were significantly higher (IL‐6: MD, 19.55 pg/mL; CI, 14.80, 24.30; IL‐8: MD, 19.18 pg/mL; CI, 2.94, 35.43; IL‐10: MD, 3.66 pg/mL; CI, 2.41, 4.92; IL‐2R: MD, 521.36 U/mL; CI, 87.15, 955.57; and TNF‐alpha: MD, 1.11 pg/mL; CI, 0.07, 2.15) and T‐lymphocyte levels were significantly lower (CD4+ T cells: MD, −165.28 cells/µL; CI, −207.58, −122.97; CD8+ T cells: MD, −106.51 cells/µL; CI, −128.59, −84.43) among severe cases as compared to nonsevere ones. There was heterogeneity across studies due to small sample sizes and nonuniformity in outcome assessment and varied definitions of disease severity. The overall quality of studies was sub‐optimal. CONCLUSION: Severe COVID‐19 is characterized by significantly increased levels of pro‐inflammatory cytokines and reduced T lymphocytes. Well‐designed and adequately powered prospective studies are needed to amplify the current evidence and provide definitive answers to dilemmas regarding timing and type of anti‐COVID‐19 therapy particularly in severe patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33058143/ doi: 10.1111/eci.13429 id: cord-255233-rvgj6pvk author: Munday, Molly-Rose title: A Pilot Study Examining Vitamin C Levels in Periodontal Patients date: 2020-07-28 words: 3895.0 sentences: 238.0 pages: flesch: 51.0 cache: ./cache/cord-255233-rvgj6pvk.txt txt: ./txt/cord-255233-rvgj6pvk.txt summary: Methods: Patients were invited to participate following assessment and treatment at the Westmead Centre of Oral Health Periodontic Clinic, regardless of current disease stage or treatment. Conclusion: Although a small study, this rate of vitamin C deficiency in the periodontal clinic is clinically important and correlations with disease severity and CRP suggests biological importance. Vitamin C deficiency is more common in smokers, the elderly and people of lower socio-economic status, potentially putting those groups at increased risk of periodontal diseases [24, 25] . Patients were eligible to participate in this study if they were an adult attending the Westmead Centre of Oral Health (WCOH) Periodontic Clinic. Patients were eligible to participate in this study if they were an adult attending the Westmead Centre of Oral Health (WCOH) Periodontic Clinic. This study reports that a significant proportion of patients attending the Periodontics Clinic at the Westmead Centre of Oral Health have vitamin C deficiency. abstract: Background: Periodontal disease is the leading cause of tooth loss worldwide. Current periodontal treatment is limited by its dependency on patients learning and maintaining good dental habits, and repeated visits to oral health physicians. Vitamin C’s role in collagen synthesis and immune function makes it important in wound healing and possibly periodontal healing. Therefore, if some patients are deficient, this may worsen patient outcomes. Methods: Patients were invited to participate following assessment and treatment at the Westmead Centre of Oral Health Periodontic Clinic, regardless of current disease stage or treatment. Adults were eligible if they gave informed consent and had current periodontal disease. Study involvement consisted of periodontal assessment and care followed by an interview and measurement of serum vitamin C and C-reactive protein (CRP). Results: A total of 6 out of 20 patients had vitamin C levels less than the institutional normal range, of whom 2 had levels <11.4 μmol/L and one <28 μmol/L. Low vitamin C was associated with higher periodontal disease stage (p = 0.03). Elevated CRP was found in 2/3 of people with low vitamin C and CRP was negatively correlated with vitamin C (p < 0.01). Vitamin C did not correlate with patient-reported fruit or vegetable consumption, but high processed meat intake was associated with lower vitamin C. Conclusion: Although a small study, this rate of vitamin C deficiency in the periodontal clinic is clinically important and correlations with disease severity and CRP suggests biological importance. This warrants further studies to assess vitamin C and whether supplementation improves periodontal outcomes, particularly in deficient subjects. url: https://www.ncbi.nlm.nih.gov/pubmed/32731485/ doi: 10.3390/nu12082255 id: cord-289064-435bp4rt author: Muniangi-Muhitu, Hermine title: Covid-19 and Diabetes: A Complex Bidirectional Relationship date: 2020-10-08 words: 5744.0 sentences: 290.0 pages: flesch: 43.0 cache: ./cache/cord-289064-435bp4rt.txt txt: ./txt/cord-289064-435bp4rt.txt summary: Identified risk factors for disease severity and death from SARS-Cov2 infection include older age, male sex, diabetes, obesity and hypertension. We consider roles for the immune system, the observed phenomenon of microangiopathy in severe Covid-19 infection and the potential for direct viral toxicity on metabolically-relevant tissues including pancreatic beta cells and targets of insulin action. (18) , patients with diabetes and hypertension who had been treated with ACE inhibitors or angiotensin receptor blockers (ARB) had a high number of ACE2 receptors in the lung, and could therefore be at higher risk of developing severe symptoms, if infected with Covid-19. With respect to the glycemic deterioration seen in patients with preexisting T2D during Covid-19, a very recent report (63) provides the intriguing observation that ACE2 expression at both the mRNA and protein is increased substantially in human beta cells in response to response to inflammatory cytokines, presumably rendering these cells more susceptible to infection. abstract: Covid-19 is a recently-emerged infectious disease caused by the novel severe acute respiratory syndrome coronavirus SARS-CoV2. SARS-CoV2 differs from previous coronavirus infections (SARS and MERS) due to its high infectivity (reproduction value, R(0), typically 2–4) and pre- or asymptomatic transmission, properties that have contributed to the current global Covid-19 pandemic. Identified risk factors for disease severity and death from SARS-Cov2 infection include older age, male sex, diabetes, obesity and hypertension. The reasons for these associations are still largely obscure. Evidence is also emerging that SARS-CoV2 infection exacerbates the underlying pathophysiology of hyperglycemia in people with diabetes. Here, we discuss potential mechanisms through which diabetes may affect the risk of more severe outcomes in Covid-19 and, additionally, how diabetic emergencies and longer term pathology may be aggravated by infection with the virus. We consider roles for the immune system, the observed phenomenon of microangiopathy in severe Covid-19 infection and the potential for direct viral toxicity on metabolically-relevant tissues including pancreatic beta cells and targets of insulin action. url: https://www.ncbi.nlm.nih.gov/pubmed/33133024/ doi: 10.3389/fendo.2020.582936 id: cord-343052-dc9s2rau author: Murgo, Salvatore title: Haemoptysis treated by bronchial artery embolisation in severe acute respiratory syndrome coronavirus 2: case report date: 2020-09-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: We found no data in the literature on the embolization of the bronchial arteries in the context of hemoptysis associated with severe acute respiratory syndrome coronavirus 2. We therefore decided to share this experience. CASE PRESENTATION: A 62-year-old patient with no significant medical history was admitted with acute respiratory distress. Chest computed tomography showed diffuse bilateral ground-glass opacities with limited consolidations. Diagnostic tests confirmed severe acute respiratory syndrome coronavirus 2 infection. The severity of respiratory failure required the implantation of veno-venous extracorporeal membrane oxygenation. The patient developed severe haemoptysis, which was successfully treated by bronchial artery embolisation. CONCLUSIONS: In the case of coronavirus-19 pneumonia, our experience suggests that the treatment of severe haemoptysis by bronchial artery embolisation is feasible and effective. The survival benefit should be assessed in the future. url: https://doi.org/10.1186/s42155-020-00154-x doi: 10.1186/s42155-020-00154-x id: cord-327609-no58ucyq author: Murkey, Jamie A. title: Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing date: 2017-06-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation. url: https://www.ncbi.nlm.nih.gov/pubmed/28721353/ doi: 10.1093/ofid/ofx121 id: cord-282660-9x937eus author: Muñoz Vives, Josep Maria title: Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study date: 2020-05-06 words: 3213.0 sentences: 173.0 pages: flesch: 51.0 cache: ./cache/cord-282660-9x937eus.txt txt: ./txt/cord-282660-9x937eus.txt summary: title: Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study All patients who were ≥65 years of age, presented to the Emergency Department of the participating hospitals during this period with a diagnosis of proximal femoral fracture, and had a minimum follow-up of 10 days were included in the cohort. Included participants were patients ‡65 years of age presenting to the Emergency Department of the participating hospitals with the clinical and radiographic diagnosis of a proximal femoral fracture (31-A and 31-B according to the OTA/AO classification 19 ) from a low-energy mechanism from March 14, 2020 (on the day that the Spanish government declared a state of national alarm due to COVID-19 and the pandemic surpassed 2,000 patients and 50 deaths from COVID-19 in Spain) until April 4, 2020, with a minimum of 10 days of follow-up. abstract: The outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), in December 2019 in Wuhan, People’s Republic of China, has developed into an unprecedented pandemic with enormous pressure on health-care providers around the world. A higher mortality rate has been described in older infected individuals. Patients with hip fracture are a particularly vulnerable population during this pandemic because older age is associated with a higher mortality rate. Our aim was to describe the early mortality rate and demographic variables in a hip fracture sample population in Spain during the coronavirus pandemic. METHODS: This is a multicenter, observational, retrospective, descriptive study. We collected data from 13 major hospitals in Spain from the beginning of the national state of alarm (declared on March 14, 2020, by the Spanish government) until the end of our study period on April 4, 2020. All patients who were ≥65 years of age, presented to the Emergency Department of the participating hospitals during this period with a diagnosis of proximal femoral fracture, and had a minimum follow-up of 10 days were included in the cohort. In addition to mortality, demographic and other potential prognostic variables were also collected. RESULTS: In this study, 136 patients with a hip fracture were included. Of these patients, 124 underwent a surgical procedure and 12 were managed nonoperatively. The total mortality rate was 9.6%. Sixty-two patients were tested for COVID-19, with 23 patients being positive. The mortality rate for these 23 patients was 30.4% (7 of 23 patients) at a mean follow-up of 14 days. The mortality rate was 10.3% (4 of 39) for patients who had been tested and had a negative result and 2.7% (2 of 74) for patients who had not been tested. Of the 12 patients who were managed nonoperatively, 8 (67%) died, whereas, of the 124 patients who were surgically treated, 5 (4%) died. Results differed among centers. CONCLUSIONS: There is a higher mortality rate in patients with a hip fracture and an associated positive test for COVID-19. LEVEL OF EVIDENCE: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence. url: https://www.ncbi.nlm.nih.gov/pubmed/32618917/ doi: 10.2106/jbjs.20.00686 id: cord-008672-luoxomif author: Mwachari, C. title: Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya date: 2004-10-29 words: 3175.0 sentences: 194.0 pages: flesch: 49.0 cache: ./cache/cord-008672-luoxomif.txt txt: ./txt/cord-008672-luoxomif.txt summary: We undertook a prospective cross-sectional study of adult patients admitted to a government hospital in Nairobi, Kenya, to determine possible bacterial, mycobacterial, parasitic and viral causes of diarrhoca; to consider which may be treatable; and to relate microbiological findings to clinical outcome. METHODS: Stool specimens from 75 consecutive HIV-seropositive patients with chronic diarrhoca admitted to a Nairobi hospital were subjected to microbiological investigation and results were compared with clinical findings and outcome. CONCLUSIONS: HIV-infected patients with chronic diarrhoea in Nairobi have a poor outcome overall, and even with extensive investigation a putative pathogen was identified in only just over half the patients. We undertook a 4-month study in Nairobi, Kenya, to determine possible bacterial, viral and parasitological causes of chronic diarrhoea and wasting using a broad range of investigations and related findings to patient outcome. abstract: OBJECTIVES: Chronic diarrhoea and wasting are well recognized features of AIDS in Africa. However, because of resource constraints few ocmprehensive aetiological studies have conducted in sub-Saharan Africa which have included a broad range of microbiological investigations. We undertook a prospective cross-sectional study of adult patients admitted to a government hospital in Nairobi, Kenya, to determine possible bacterial, mycobacterial, parasitic and viral causes of diarrhoca; to consider which may be treatable; and to relate microbiological findings to clinical outcome. METHODS: Stool specimens from 75 consecutive HIV-seropositive patients with chronic diarrhoca admitted to a Nairobi hospital were subjected to microbiological investigation and results were compared with clinical findings and outcome. Stool samples were cultured for bacteria and mycobacteria and underwent light and electron microscopy; lawns of Escherichica coli were probed for pathogenic types and aliquots were tested for the presence of Clostridium difficile cytotoxin. Blood cultures for mycobacteria and other bacterial pathogens were performed as clinically indicated. RESULTS: Thirty-nine (52%) patients yielded putative pathogens, the most common being Cryptosporidium sp. (17%), Salmonella typhimurium (13%), and Mycobacterium tuberculosis (13%). Of 41 patients investigated for pathogenic Escherichia coli, enteroaggregative E. coli and diffusely adherent E. coli were each found in four patients. Thirty-one (41%) patients died. Detection of cryptosporidium cysts was the single most significant predictor of death (X(2) = 5.2, P<0.05). Many patients did not improve (21; 285) or self-discharged whilst still sick (5; 7%) but five (7%) were diagnosed ante mortem with tuberculosis and treated and a further 13 (17%) showed improvement by time of discharge. CONCLUSIONS: HIV-infected patients with chronic diarrhoea in Nairobi have a poor outcome overall, and even with extensive investigation a putative pathogen was identified in only just over half the patients. The most important step is to exclude tuberculosis: and the most useful investigation appears to be Ziehl-Neelsen staining. Other potentially treatable Gram-negative bacterial pathogens, S. typhimurium, Shigella sp. and adherent E. coli were, however, common but require culture facilities which are not widely accessible for definitive identification. Further studies focussing on simple ways to identify sub-groups of patients with treatable infections are warranted. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133614/ doi: 10.1016/s0163-4453(98)90561-8 id: cord-285757-fiqx4tll author: Mäkelä, M. J. title: Lack of Induction by Rhinoviruses of Systemic Type I Interferon Production or Enhanced MxA Protein Expression During the Common Cold date: 1999 words: 1825.0 sentences: 97.0 pages: flesch: 50.0 cache: ./cache/cord-285757-fiqx4tll.txt txt: ./txt/cord-285757-fiqx4tll.txt summary: To study whether MxA protein expression is systemically upregulated during rhinovirus infection, blood specimens were collected from 40 patients with common cold and MxA expression in mononuclear cells analyzed by flow cytometry. In conclusion, expression of MxA in blood lymphocytes and an apparently systemic type I interferon response is not induced during rhinovirus infection or during most other cases of common cold in young adult patients. In the present study, the induction of a systemic IFN response as reflected by the expression of MxA protein in blood lymphocytes of patients with rhinovirus infection was examined. Our data suggests that type I IFN production in serum is not comparable to that seen in most other respiratory viral infections in vivo, since the rhinovirus-positive patients had only low or no expression of the MxA protein and no IFN-a/b was detectable in serum samples. abstract: To study whether MxA protein expression is systemically upregulated during rhinovirus infection, blood specimens were collected from 40 patients with common cold and MxA expression in mononuclear cells analyzed by flow cytometry. None of the patients with a confirmed rhinovirus infection (n=15) or with an infection of unknown etiology (n=20) had elevated expression of the MxA protein (median fluorescence intensity, 549 and 582, respectively) when compared to healthy controls (n=11, median 590). Patients with influenza infections had significantly elevated values (n=5, median 750), and interferon could be detected only in serum samples from influenza patients. In conclusion, expression of MxA in blood lymphocytes and an apparently systemic type I interferon response is not induced during rhinovirus infection or during most other cases of common cold in young adult patients. url: https://www.ncbi.nlm.nih.gov/pubmed/10534191/ doi: 10.1007/s100960050370 id: cord-281060-1ud5hzlh author: Méndez Maestro, Irune title: Skin manifestations in patients hospitalized with confirmed COVID‐19 disease: a cross‐sectional study in a tertiary hospital date: 2020-09-24 words: 1588.0 sentences: 104.0 pages: flesch: 49.0 cache: ./cache/cord-281060-1ud5hzlh.txt txt: ./txt/cord-281060-1ud5hzlh.txt summary: BACKGROUND: COVID‐19 cutaneous manifestations have been recently described and classified in five different clinical patterns, including acral erythema‐edema (pseudo‐chilblain), maculopapular exanthemas, vesicular eruptions, urticarial lesions, and livedo or necrosis. We decided to perform this study to describe the real prevalence and directly examine the skin findings in hospitalized patients in our institution with a confirmed diagnosis of COVID-19 disease. We performed a cross-sectional study, which included COVID19 Based on recent reports 4-16 and on the Spanish group classification in clinical patterns, 17 we included acral erythemaedema (pseudo-chilblain), maculopapular exanthemas, vesicular eruptions, urticarial lesions, and livedo or necrosis areas. All skin findings can be included in the recently described clinical patterns of cutaneous manifestations of COVID-19 disease. In our study, we did not correlate the severity of the COVID-19 disease with the different skin patterns because all of the patients we included had very similar clinical characteristics of COVID-19 (moderate-severe infection that required hospitalization). abstract: BACKGROUND: COVID‐19 cutaneous manifestations have been recently described and classified in five different clinical patterns, including acral erythema‐edema (pseudo‐chilblain), maculopapular exanthemas, vesicular eruptions, urticarial lesions, and livedo or necrosis. OBJECTIVES: The objective of this study was to examine the skin of hospitalized patients with a confirmed diagnosis of COVID‐19 disease and describe the real prevalence of skin manifestations. METHODS: A cross‐sectional study, which included hospitalized patients in Cruces University Hospital from April 14–30, 2020, with a laboratory‐confirmed diagnosis of COVID‐19 (with polymerase chain reaction and/or serology tests), was conducted. Entire body surface examination was performed by experienced dermatologists to search for cutaneous manifestations related to COVID‐19 disease. RESULTS: From a sample of 75 patients, 14 (18.7%) developed cutaneous manifestations possibly related to COVID‐19. We found six patients with acral erythema‐edema (pseudo‐chilblain) (42.8%), four patients with maculopapular exanthemas (28.6%), two patients with urticarial lesions (14.3%), one patient with livedo reticularis‐like lesions (7.15%), and one patient with vesicular eruption (7.15%). CONCLUSIONS: Our study provides a more plausible relationship between the main cutaneous patterns and COVID‐19 in hospitalized patients as all of them had a confirmatory laboratory test. Skin manifestations are frequent but mild with spontaneous resolution. These findings are nonspecific and can be similar to other viral infections and adverse drug reactions in hospitalized patients. url: https://doi.org/10.1111/ijd.15180 doi: 10.1111/ijd.15180 id: cord-287758-da11ypiy author: Mônica Vitalino de Almeida, Sinara title: COVID-19 therapy: what weapons do we bring into battle? date: 2020-09-10 words: 17412.0 sentences: 1034.0 pages: flesch: 45.0 cache: ./cache/cord-287758-da11ypiy.txt txt: ./txt/cord-287758-da11ypiy.txt summary: The increase in studies related to SARS-CoV-2 during the first semester in 2020 has allowed the rather speedy identification of promising therapeutic targets for both developing immunotherapies and producing/identifying antiviral drugs. 5, 64 So far, structural proteins and enzymes that participate actively in the process of viral replication are the most investigated targets for the development of molecules for anti-CoVs therapies (FIG. Based on results from previous studies as well, nelfinavir was considered a likely therapy for COVID-19 after its indication for clinical trials as a promising anti-SARS drug. 218 In addition to this well-known antitumor effect, imatinib has also shown in-vitro antiviral properties against several virus, such as infectious bronchitis virus (a viral model for studying the role of tyrosine kinase activity during CoV infection), by interfering with virus-cell fusion, 219 and other RNA viruses including coxsackie virus, 220 hepatitis C virus, 221 Ebola, 222 among others, mainly by blocking viral entry or egress from the host cell. abstract: Urgent treatments, in any modality, to fight SARS-CoV-2 infections are desired by society in general, by health professionals, by Estate-leaders and, mainly, by the scientific community, because one thing is certain amidst the numerous uncertainties regarding COVID-19: knowledge is the means to discover or to produce an effective treatment against this global disease. Scientists from several areas in the world are still committed to this mission, as shown by the accelerated scientific production in the first half of 2020 with over 25,000 published articles related to the new coronavirus. Three great lines of publications related to COVID-19 were identified for building this article: The first refers to knowledge production concerning the virus and pathophysiology of COVID-19; the second regards efforts to produce vaccines against SARS-CoV-2 at a speed without precedent in the history of science; the third comprehends the attempts to find a marketed drug that can be used to treat COVID-19 by drug repurposing. In this review, the drugs that have been repurposed so far are grouped according to their chemical class. Their structures will be presented to provide better understanding of their structural similarities and possible correlations with mechanisms of actions. This can help identifying anti-SARS-CoV-2 promising therapeutic agents. url: https://doi.org/10.1016/j.bmc.2020.115757 doi: 10.1016/j.bmc.2020.115757 id: cord-296881-2g81sjnl author: Nabil, Ahmed title: Current coronavirus (SARS-CoV-2) epidemiological, diagnostic and therapeutic approaches: An updated review until June 2020 date: 2020-07-20 words: 4802.0 sentences: 253.0 pages: flesch: 43.0 cache: ./cache/cord-296881-2g81sjnl.txt txt: ./txt/cord-296881-2g81sjnl.txt summary: On May 7, 2020, Gilead Sciences, announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) has granted regulatory approval of Veklury® (Remdesivir) as a treatment for SARS-CoV-2 infection, the virus that causes COVID-19 acute respiratory syndrome, under an exceptional approval pathway. In COVID-19 infection, a massive number of T-lymphocytes and mononuclear macrophages are activated, emitting different cytokines such as interleukin-6 (IL-6), which binds to the IL-6 receptor on its target cells, causing the cytokine storm and severe inflammatory responses in most organs including lungs, liver, kidney and other tissues and organs. Moreover, in July 2020 the WHO discontinued clinical trials with hydroxychloroquine and lopinavir/ritonavir treatment arms for COVID-19 (WHO, 2020b), where both therapies produced little and no reduction in the mortality of hospitalized SARS-CoV-2 cases when compared to standard of care. COVID-19 infection and treatment with hydroxychloroquine cause severe haemolysis crisis in a patient with glucose-6-phosphate dehydrogenase deficiency abstract: Coronaviruses are a group of enveloped viruses with non-segmented, single-stranded, and positive-sense RNA genomes. In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in Wuhan City, China. The World Health Organization (WHO) declared the coronavirus outbreak as a global pandemic in March 2020. Fever, dry cough and fatigue are found in the vast majority of all COVID-19 cases. Early diagnosis, treatment and future prevention are keys to COVID-19 management. Currently, the unmet need to develop cost-effective point-of-contact test kits and efficient laboratory techniques for confirmation of COVID-19 infection has powered a new frontier of diagnostic innovation. No proven effective therapies or vaccines for SARS-CoV-2 currently exist. The rapidly increasing research regarding COVID-19 virology provides a significant number of potential drug targets. Remdesivir may be the most promising therapy up till now. On May 1, 2020, Gilead Sciences, announced that the U.S. Food and Drug Administration (FDA) has granted emergency use authorization (EUA) for the investigational Remdesivir as a potential antiviral for COVID-19 treatment. On May 7, 2020, Gilead Sciences, announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) has granted regulatory approval of Veklury® (Remdesivir) as a treatment for SARS-CoV-2 infection, the virus that causes COVID-19 acute respiratory syndrome, under an exceptional approval pathway. Also, Corticosteroids are recommended for severe cases only to suppress the immune response and reduce symptoms, but not for mild and moderate patients where they are associated with a high-risk side effect. Based on the currently published evidence, we tried to highlight different diagnostic approaches, side effects and therapeutic agents that could help physicians in the frontlines. url: https://www.ncbi.nlm.nih.gov/pubmed/32788913/ doi: 10.17179/excli2020-2554 id: cord-294443-w6p3f5qc author: Nadar, Sunil K. title: Managing hypertension during the COVID-19 pandemic date: 2020-05-14 words: 1642.0 sentences: 82.0 pages: flesch: 48.0 cache: ./cache/cord-294443-w6p3f5qc.txt txt: ./txt/cord-294443-w6p3f5qc.txt summary: Concern was therefore raised at the start of the pandemic that ACE inhibitors and angiotensin receptor blockers (ARBs), medications that are commonly used for hypertension and heart failure, could have a potential deleterious effect [11] , as ACE2 is widely expressed in the cardiovascular system and is up regulated by these drugs in some tissues in a subset of animal models [12, 13] . Subsequent data have raised the possibility that patients treated with ACE inhibitors or ARBs do indeed have a better outcome, with the crucial caveat that the possibility of unmeasured confounding and bias precludes drawing cause-effect conclusions from the clinical studies available thus far. A recent retrospective study from China comparing outcomes on hospitalised patients with COVID-19 with and without ACE inhibitors or ARBs for hypertension has suggested that in the former all-cause mortality was lower (adjusted HR, 0.42; 95% CI, 0.19-0.92; P = 0.03) [18] . Retrospective study of risk factors for severe SARS-Cov-2 infections in hospitalized adult patients. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32409727/ doi: 10.1038/s41371-020-0356-y id: cord-004986-en7taikk author: Nagy, Nathalie title: Infections gastro-intestinales chez le patient immunocompromis date: 2002 words: 6147.0 sentences: 672.0 pages: flesch: 58.0 cache: ./cache/cord-004986-en7taikk.txt txt: ./txt/cord-004986-en7taikk.txt summary: Dans 44 h 68 % des patients sida prEsentant une entEropathie due ~un ou plusieurs agents pathogEnes concomitant, des symptEmes gastro-intestinaux sont retrouvEs. Le diagnostic d''infections opportunistes est en gEnEral base sur une combinaison de culture de selles, examen direct des selles ~ la recherche d''ceufs ou de larves, et d''une biopsie endoscopique. L''infection herpEtique semble 6tre plus frEquente chez le patient HIV que chez les autres patients immunodEprimEs. Dans une importante Etude prospective r6alisEe sur 100 patients HIV pr6sentant une cesophagite her-pEtique, le virus HSV n''a 6tE identifi6 que darts 5 % des cas alors que la prevalence du virus CMV atteignait 50 % [4] . Les infections ~ Campylobacter ont 6t6 identifi6es dans approximativement 11% des coprocultures des patients sida, qu''ils souffrent ou non de diarrh6es ; ces patients, pr6sentant une incidence d''infection, sont 39 fois plus importants que dans la population g6n6rale. Cependant une colonisation m6me par des agents non pathog6nes peut 8tre responsable d''affections s6vhres chez les patients immunocompromis [6] . abstract: The gastrointestinal tract is frequently involved in immunocompromised hosts. The most common digestive manifestations are dysphagia, odynophagia and diarrhea. These diseases are more frequent in patients with acquired immunodeficiency virus (AIDS). These GI diseases are of several categories: HIV related inflammatory conditions (HIV related enteropathy, idiopathic esophageal ulceration), infections due to germs also commonly present in immunocompetent patients (Salmonellosis, shigellosis,…), opportunistic infections (CMV, Mucormycosis,Cryptosporidium, Mycobacterium, Isospora belli,…). The prevalence, pathogenesis, clinical manifestation, gross pathological findings and microscopic features are discussed for each entity. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087899/ doi: 10.1007/bf03016656 id: cord-018318-vzzrsqsn author: Naidu, C. Sudeep title: Postoperative Liver Failure date: 2017-02-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Technical innovations in surgical techniques, anaesthesia, critical care and a spatial understanding of the intra-hepatic anatomy of the liver, have led to an increasing number of liver resections being performed all over the world. However, the number of complications directly attributed to the procedure and leading to inadequate or poor hepatic functional status in the postoperative period remains a matter of concern. There has always been a problem of arriving at a consensus in the definition of the term: postoperative liver failure (PLF). The burgeoning rate of living donor liver transplants, with lives of perfectly healthy donors involved, has mandated a consensual definition, uniform diagnosis and protocol for management of PLF. The absence of a uniform definition has led to poor comparison among various trials. PLF remains a dreaded complication in resection of the liver, with a reported incidence of up to 8 % [1], and mortality rates of up to 30–70 % have been quoted [2]. Several studies have quoted a lower incidence of PLF in eastern countries, but when it occurs the mortality is as high as in the West [3]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123164/ doi: 10.1007/978-981-10-2678-2_3 id: cord-001536-ta1i0ata author: Nair, Girish B title: Year in review 2013: critical care - respiratory infections date: 2014-10-29 words: 8891.0 sentences: 335.0 pages: flesch: 37.0 cache: ./cache/cord-001536-ta1i0ata.txt txt: ./txt/cord-001536-ta1i0ata.txt summary: New studies have suggested strategies to identify patients at risk for resistant pathogen infection and therapies that optimize efficacy, without the overuse of broad-spectrum therapy in patients with healthcare-associated pneumonia. Infections, mostly nosocomial, are a major cause of mortality in hospitalized patients related to an increased risk of infection with multi-drug resistant (MDR) pathogens and the widespread use of indiscriminate broad-spectrum antibiotics. In a study including 519 patients with CAP and 419 with HCAP, the authors compared the performance of Pneumonia Severity Index (PSI) and CURB-65 risk scores for predicting 30-day mortality [20] . Maruyama and colleagues [23] , in a prospective study of 425 patients (CAP = 124, HCAP = 321), applied a therapeutic algorithm based on the presence of MDR risk factors (immunosuppression, hospitalization within the last 90 days, poor functional status indicated by a Barthel Index score <50, and antibiotic therapy within the past 6 months) and severity of illness (need for ICU admission or requiring MV) to determine its impact on outcomes. abstract: Infectious complications, particularly in the respiratory tract of critically ill patients, are related to increased mortality. Severe infection is part of a multiple system illness and female patients with severe sepsis have a worse prognosis compared to males. Kallistatin is a protective hormokine released during monocyte activation and low levels in the setting of septic shock can predict adverse outcomes. Presepsin is another biomarker that was recently evaluated and is elevated in patients with severe sepsis patients at risk of dying. The Centers for Disease Control and Prevention has introduced new definitions for identifying patients at risk of ventilator-associated complications (VACs), but several other conditions, such as pulmonary edema and acute respiratory distress syndrome, may cause VACs, and not all patients with VACs may have ventilator-associated pneumonia. New studies have suggested strategies to identify patients at risk for resistant pathogen infection and therapies that optimize efficacy, without the overuse of broad-spectrum therapy in patients with healthcare-associated pneumonia. Innovative strategies using optimized dosing of antimicrobials, maximizing the pharmacokinetic and pharmacodynamic properties of drugs in critically ill patients, and newer routes of drug delivery are being explored to combat drug-resistant pathogens. We summarize the major clinical studies on respiratory infections in critically ill patients published in 2013. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330923/ doi: 10.1186/s13054-014-0572-3 id: cord-300356-oorac5he author: Nair, Girish B. title: Community-Acquired Pneumonia: An Unfinished Battle date: 2011-10-05 words: 7378.0 sentences: 340.0 pages: flesch: 41.0 cache: ./cache/cord-300356-oorac5he.txt txt: ./txt/cord-300356-oorac5he.txt summary: 20 Risk factors for community-acquired P aeruginosa pneumonia include bronchiectasis, immunocompromised state, use of multiple courses of antibiotics, prolonged glucocorticoids in patients with COPD, and recent hospitalization. One of the most important decisions in the management of pneumonia is to assess the severity of the disease, which can be used to predict mortality risk and may be Nair & Niederman a surrogate measure to define the site of care (outpatient, hospital ward, or ICU). 61, 62 Although administration of therapy within 4 to 6 hours of arrival at the hospital can reduce mortality, it is important to only use antibiotics when the diagnosis is certain, because indiscriminate use of antibiotics in the absence of radiographic pneumonia has limited benefit and a real risk of Community-Acquired Pneumonia antibiotic-associated adverse events, including drug-induced infectious diarrhea. abstract: Community-acquired pneumonia remains a common illness with substantial morbidity and mortality. Current management challenges focus on identifying the likely etiologic pathogens based on an assessment of host risk factors, while attempting to make a specific etiologic diagnosis, which is often not possible. Therapy is necessarily empiric and focuses on pneumococcus and atypical pathogens for all patients, with consideration of other pathogens based on specific patient risk factors. It is important to understand the expected response to effective therapy, and to identify and manage clinical failure at the earliest possible time point. Prevention is focused on smoking cessation and vaccination against pneumococcus and influenza. url: https://api.elsevier.com/content/article/pii/S0025712511000927 doi: 10.1016/j.mcna.2011.08.007 id: cord-017142-vx3rgs4r author: Nair, Ranjit title: What the Intensivists Need to Know About Critically Ill Myeloma Patients date: 2019-07-09 words: 9343.0 sentences: 460.0 pages: flesch: 36.0 cache: ./cache/cord-017142-vx3rgs4r.txt txt: ./txt/cord-017142-vx3rgs4r.txt summary: Suspicion of cast nephropathy in newly diagnosed myeloma patients with serum FLC above 1000 mg/L should be high, especially if associated selective proteinuria composed of FLC/BJP exists, as the degree of renal injury is usually related to tumor load [55] . MM patients are at high risk for cardiac complications secondary multiple factors including an older age group of patients with underlying comorbidities, concurrent kidney involvement, MM-associated deposition disease, and/or anti-MM drug-related side effects. Cardiac amyloidosis can be clinically silent initially, and a MM patient presenting with progressive dyspnea, worsening edema with evidence of heart failure, or dysrhythmia presenting as syncope or hypotensive event requires a thorough work-up to rule out coexisting amyloid disease. Immunosuppression is mediated by disease-and treatment-related factors including decreased ratio of functional to dysfunctional immunoglobulins, defects in antibody opsonization, steroid-related T cell defects, secondary immunodeficiency related to chemotherapy, restricted pulmonary reserve from thoracic rib fractures and opiate use, mucosal damage, indwelling catheters, and presence of renal failure [53, 88, 100] . abstract: Multiple myeloma (MM) is a hematological malignancy characterized by an increase in aberrant plasma cells in the bone marrow leading to rising monoclonal protein in serum and urine. With the introduction of novel therapies with manageable side effects, this incurable disease has evolved into a chronic disease with an acceptable quality of life for the majority of patients. Accordingly, management of acute complications is fundamental in reducing the morbidity and mortality in MM. MM emergencies include symptoms and signs related directly to the disease and/or to the treatment; many organs may be involved including, but not limited to, renal, cardiovascular, neurologic, hematologic, and infectious complications. This review will focus on the numerous approaches that are aimed at managing these complications. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121630/ doi: 10.1007/978-3-319-74588-6_98 id: cord-263882-s5oxr6es author: Najar Nobar, Niloufar title: Patients with specific skin disorders who are affected by COVID‐19: what do experiences say about management strategies? : A systematic review date: 2020-06-18 words: 2543.0 sentences: 145.0 pages: flesch: 41.0 cache: ./cache/cord-263882-s5oxr6es.txt txt: ./txt/cord-263882-s5oxr6es.txt summary: It seems that in patients with any severe and serious dermatologic disorders, under treatment with systemic agents, if there is not any suspicion about concurrent infection or any high risk exposures, not only it is not recommend to cessation therapy but only emphasize that these drugs could prevent disease flare-up and control cytokine storm that both in a negative direction, affect the COVID-19 course (41) (42) (43) (44) (45) (46) (47) (48) . So in this systematic review we focused on specific patient groups with a dermatologic disorder (usually under therapy) that concomitantly have been infected by the new corona virus and summed up their data in all aspects of underlying and infectious disease course and management. At the time of the COVID-19, the biologic agents were discontinued except for one case (which was treated with Guselkumab) but the patients did not report any severe exacerbation of their underlying dermatologic disease despite treatment discontinuation. abstract: BACKGROUND AND AIM: In patients with dermatologic disorders who are affected by new corona virus, we know little about course (underlying disease and new onset‐infection) and the most proper management strategies include both issues that are what this systematic review targets. METHOD: Databases of PubMed, Scopus, Google Scholar, Medscape and CEBD coronavirus dermatology resource of Nottingham University searched completely and initial 237 articles selected to further review and finally nine articles (including 12 patients) entered to this study. RESULT: from 12 patients with chronic underlying dermatologic disease treated with systemic therapies, only one patient required ICU admission, the others have been treated for mild‐ moderate symptoms with conventional therapies. The biologic or immunosuppressive/ Immunomodulator agents has been ceased during the course of disease. The course of COVID‐19 its management was as similar as normal populations. Their underlying dermatologic disease was exacerbating from mild to moderate. Their treatment has been continued as before, after the symptoms improved. CONCLUSION: Exacerbation of patients underlying dermatologic disease is mild‐ moderate. Discontinuing the treatment in the acute period of COVID and the restart after recovery may prevent severe recurrence in these patients. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32558193/ doi: 10.1111/dth.13867 id: cord-016105-jkaxemmb author: Nakao, Mutsuhiro title: Prevention and Psychological Intervention in Depression and Stress-Related Conditions date: 2011 words: 4505.0 sentences: 202.0 pages: flesch: 37.0 cache: ./cache/cord-016105-jkaxemmb.txt txt: ./txt/cord-016105-jkaxemmb.txt summary: Through such quasi experience-based studies, medical students can not only acquire knowledge and develop the desired professional attitudes and behaviors but can also come to learn about the psychological and social problems actually experienced by patients. The case-method approach also offers the advantage of using actual cases to learn about the multidimensional issues involved in various aspects of medical practice, such as drawing on knowledge as the basis of actions, understanding the backgrounds of patients, and maintaining awareness of personal motivations and ethical concerns. Based on the need for these procedures, the proposed problem-solving paradigm includes the following phases: (1) defining the problem, (2) measuring its magnitude, (3) understanding key determinants, (4) developing prevention/intervention strategies, (5) setting policy/priorities, (6) identifying the best solution, and (7) implementing and evaluating the solution. Our experiences with CBT have identified problems with using this approach to treat depression in Japan and have underscored issues that require further consideration to improve the effectiveness of treatment offered in actual clinical settings. abstract: This chapter focuses on depression and stress-related conditions to discuss possible strategies for the prevention or early management of such conditions. Health education constitutes the first important strategy, and we outline a school-based educational activity using a case-method approach. We next illustrate the impact of stressful events on psychological health with the results of a survey among Chinese individuals conducted after an unexpected epidemic of severe acute respiratory syndrome in 2003. Communication plays an important role in the assessment and management services provided by medical practitioners to sick individuals, with very diverse backgrounds and levels of medical knowledge, who consult health care providers with concerns about their health. In this context, we introduce a recent advance in patient–doctor communication. Finally, we address the cognitive and behavioral features of those who suffer from depression and psychosocial stress. Based on our recent activities and on evidence pertaining to health promotion and education, we emphasize the importance of health education and communication in the prevention of stress-related diseases and the promotion of physical and psychological health. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120288/ doi: 10.1007/978-4-431-53889-9_34 id: cord-287505-ihqzpdar author: Narain, Sonali title: Comparative Survival Analysis of Immunomodulatory Therapy for COVID-19 ''Cytokine Storm'' date: 2020-10-17 words: 3650.0 sentences: 222.0 pages: flesch: 42.0 cache: ./cache/cord-287505-ihqzpdar.txt txt: ./txt/cord-287505-ihqzpdar.txt summary: Patients were subdivided into six groups—no immunomodulatory treatment (standard of care) and five groups that received either corticosteroids, anti-interleukin 6 antibody (tocilizumab) or anti-interleukin-1 therapy (anakinra) alone or in combination with corticosteroids. Furthermore, corticosteroid use either alone or in combination with tocilizumab or anakinra was associated with reduced hospital mortality for patients with COVID-19 cytokine storm compared to standard of care. In this retrospective study, we leveraged this natural experiment to compare mortality in patients meeting criteria for CCS who received different combinations of these immunomodulatory drugs. Primary objective: To compare in-hospital mortality among COVID-19 patients with CCS who received combinations of immunomodulatory treatments versus SoC. Our study is the largest retrospective analysis to date reporting on outcomes comparing the use of immunomodulatory therapies such as corticosteroids, tocilizumab and anakinra in the treatment of COVID-19 CCS. Corticosteroid use, either alone or in combination with tocilizumab or anakinra, was associated with lower hospital mortality compared to standard of care. abstract: Background Cytokine storm is a marker of COVID-19 illness severity and increased mortality. Immunomodulatory treatments have been repurposed to improve mortality outcomes. Research Question To identify if immunomodulatory therapies improve survival in patients with COVID-19 cytokine storm. Study Design and Methods We conducted a retrospective analysis of electronic health records across the Northwell Health system. COVID-19 patients hospitalized between March 1, 2020 and April 24, 2020 were included. Cytokine storm was defined by inflammatory markers: ferritin >700ng/mL, C-reactive protein >30mg/dL or lactate dehydrogenase >300U/L. Patients were subdivided into six groups—no immunomodulatory treatment (standard of care) and five groups that received either corticosteroids, anti-interleukin 6 antibody (tocilizumab) or anti-interleukin-1 therapy (anakinra) alone or in combination with corticosteroids. The primary outcome was hospital mortality. Results 5,776 patients met the inclusion criteria. The most common comorbidities were hypertension (44-59%), diabetes (32-46%) and cardiovascular disease (5-14%). Patients most frequently met criteria with high lactate dehydrogenase (76.2%) alone or in combination, followed by ferritin (63.2%) and C-reactive protein (8.4%). More than 80% of patients had an elevated D-dimer. Patients treated with corticosteroids and tocilizumab combination had lower mortality compared to standard of care (Hazard Ratio (HR):0.44, 95% confidence interval (CI): 0.35-0.55; p<0.0001) and when compared to corticosteroids alone (HR:0.66, 95%CI: 0.53-0.83; p-value=0.004), or in combination with anakinra (HR:0.64, 95%CI:0.50-0.81; p-value=0.003) . Corticosteroids when administered alone (HR:0.66, 95%CI:0.57-0.76; p<0.0001) or in combination with tocilizumab (HR:0.43, 95%CI:0.35-0.55; p<0.0001) or anakinra (HR:0.68, 95%CI:0.57-0.81; p<0.0001) improved hospital survival compared to standard of care. Interpretation The combination of corticosteroids with tocilizumab had superior survival outcome when compared to standard of care and corticosteroids alone or in combination with anakinra. Furthermore, corticosteroid use either alone or in combination with tocilizumab or anakinra was associated with reduced hospital mortality for patients with COVID-19 cytokine storm compared to standard of care. url: https://doi.org/10.1016/j.chest.2020.09.275 doi: 10.1016/j.chest.2020.09.275 id: cord-348458-dwj90mbq author: Narula, Nupoor title: Cardiology Practice and Training Post-COVID-19: Achieving “Normalcy” After Disruption date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32703519/ doi: 10.1016/j.jacc.2020.06.036 id: cord-355384-qa7grviy author: NaserEddin, Adeeb title: Bacillus Calmette–Guerin (BCG) Vaccine-associated Complications in Immunodeficient Patients Following Stem Cell Transplantation date: 2020-10-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Bacillus Calmette–Guerin (BCG) is a live attenuated vaccine with the potential of causing severe iatrogenic complications in patients with primary immunodeficiency diseases (PID) before and after hematopoietic stem cell transplantation (HSCT). We aim to investigate risk factors of post-HSCT BCG-related complications in PID patients. METHODS: A retrospective analysis of pediatric PID patients who had received the BCG vaccine and underwent HSCT at Hadassah-Hebrew University Medical Center, between 2007 and 2019. RESULTS: We found 15/36 (41.67%) patients who developed post-HSCT BCG-related complications. The most significant risk factor for developing BCG-related complications was T cell deficiency (47.6% of the non-complicated vs 83.3% of the BCGitis and 100% of the BCGosis groups had T cell lymphopenia, p = 0.013). None of the chronic granulomatous patients developed BCG-related manifestation post-transplant. Among T cell–deficient patients, lower NK (127 vs 698 cells/μl, p = 0.04) cell counts and NK-SCID were risk factors for ongoing post-HSCT BCGosis, as was pretransplant disseminated BCGosis (33.3% of patients with BCGosis vs none of the non-BCGosis patients, p = 0.04). Immune reconstitution inflammatory syndrome (IRIS) was observed in 3/5 patients with Omenn syndrome. Prophylactic antimycobacterial treatment was not proven effective. CONCLUSION: BCG vaccination can cause significant morbidity and mortality in the post-transplant T cell–deficient patient, especially in the presence of pre-transplant disease. Taking a detailed medical history prior to administering, the BCG vaccine is crucial for prevention of this complication. url: https://doi.org/10.1007/s10875-020-00892-6 doi: 10.1007/s10875-020-00892-6 id: cord-352901-ia34l2ml author: Natalello, Gerlando title: Nailfold capillaroscopy findings in patients with coronavirus disease 19: Broadening the spectrum of covid-19 microvascular involvement() date: 2020-09-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Increasing evidence points to endothelial dysfunction as a key pathophysiological factor in coronavirus disease-2019 (COVID-19). No specific methods have been identified to predict, detect and quantify the microvascular alterations during COVID-19. Our aim was to assess microvasculature through nailfold videocapillaroscopy (NVC) in COVID-19 patients. METHODS: We performed NVC in patients with a confirmed diagnosis of COVID-19 pneumonia. Elementary alterations were reported for each finger according to a semi-quantitative score. Capillary density, number of enlarged and giant capillaries, number of micro-hemorrhages and micro-thrombosis (NEMO score) were registered. RESULTS: We enrolled 82 patients (mean age 58.8 ± 13.2 years, male 68.3%) of whom 28 during the hospitalization and 54 after recovery and hospital discharge. At NVC examination we found abnormalities classifiable as non-specific pattern in 53 patients (64.6%). Common abnormalities were pericapillary edema (80.5%), enlarged capillaries (61.0%), sludge flow (53.7%), meandering capillaries and reduced capillary density (50.0%). No pictures suggestive of scleroderma pattern have been observed. Acute COVID-19 patients, compared to recovered patients, showed a higher prevalence of hemosiderin deposits as a result of micro-hemorrhages (P = .027) and micro-thrombosis (P < .016), sludge flow (P = .001), and pericapillary edema (P < .001), while recovered patients showed a higher prevalence of enlarged capillaries (P < .001), loss of capillaries (P = .002), meandering capillaries (P < .001), and empty dermal papillae (P = .006). CONCLUSION: COVID-19 patients present microvascular abnormalities at NVC. Currently ill and recovered subjects are characterized by a different distribution of elementary capillaroscopic alterations, resembling acute and post-acute microvascular damage. Further studies are needed to assess the clinical relevance of NVC in COVID-19. url: https://doi.org/10.1016/j.mvr.2020.104071 doi: 10.1016/j.mvr.2020.104071 id: cord-022050-h24f0fpd author: Naughton, Matthew T. title: Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Asthma date: 2009-05-15 words: 6991.0 sentences: 345.0 pages: flesch: 41.0 cache: ./cache/cord-022050-h24f0fpd.txt txt: ./txt/cord-022050-h24f0fpd.txt summary: • Hypercapnic chronic obstructive pulmonary disease (COPD) patients should be treated with noninvasive ventilation and supplemental oxygen sufficient to overcome hypoxemia but avoid hyperoxia. Uncontrolled oxygen administration may precipitate acute hypercapnia in patients with acute COPD exacerbations as a result of relaxing hypoxic vasoconstriction, thereby allowing increased perfusion to regions with reduced alveolar ventilation. Most commonly, patients with severe asthma have a history of previous hospitalizations for asthma (some that may be near fatal), low socioeconomic status, female gender, obesity, nighttime symptoms, FEV 1 less than 60% with optimal treatment, continual symptoms, reduced quality of life, use of oral or systemic steroids in the past 12 months, use of more than canister of SABA per month, elevated residual volume-tototal lung capacity (RV:TLC) ratio on pulmonary function testing, and a peak expiratory flow rate variability of more than 30% (i.e., variability-(bestworst)/best reading). Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152396/ doi: 10.1016/b978-0-323-02844-8.50029-9 id: cord-276264-wgzh3f5m author: Navlakha, S. title: Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning date: 2020-08-25 words: 4665.0 sentences: 322.0 pages: flesch: 53.0 cache: ./cache/cord-276264-wgzh3f5m.txt txt: ./txt/cord-276264-wgzh3f5m.txt summary: Although previous studies have uncovered factors that increase risk of severe COVID-19 infection --e.g., older age, obesity, or pre-existing heart or lung disease [1] [2] [3] [4] --the clinical course and outcome of patients with COVID-19 illness remains variable and difficult for clinicians to predict. To help clinicians predict COVID-19 severity [5, 6] , we turned to robust machine learning methods to identify high-risk cancer patients based on their pre-existing conditions and initial clinical manifestations. In this study, we developed a model to predict clinical outcomes (level of oxygen support needed) in cancer patients, using only clinical variables that were available on or before COVID-19 diagnosis (called time zero). Previous machine learning studies have reported impressive performance predicting COVID-19 outcomes for non-cancer patients using only a few clinical variables. We used machine learning algorithms to identify clinical variables predictive of severe COVID-19 illness in cancer patients at time zero. abstract: Background: Accurately predicting outcomes for cancer patients with COVID-19 has been clinically challenging. Numerous clinical variables have been retrospectively associated with disease severity, but the predictive value of these variables, and how multiple variables interact to increase risk, remains unclear. Methods: We used machine learning algorithms to predict COVID-19 severity in 354 cancer patients at Memorial Sloan Kettering Cancer Center in New York City. Using clinical variables only collected on or before a patient's COVID-19 positive date (time zero), we sought to classify patients into one of three possible future outcomes: Severe-early (the patient required high levels of oxygen support within 3 days of being tested positive for COVID-19), Severe-late (the patient required high levels of oxygen after 3 days), and Non-severe (the patient never required oxygen support). Results: Our algorithm classified patients into these classes with an AUROC ranging from 70-85%, significantly outperforming prior methods and univariate analyses. Critically, classification accuracy is highest when using a potpourri of clinical variables -- including patient demographics, pre-existing diagnoses, laboratory and radiological work, and underlying cancer type -- suggesting that COVID-19 in cancer patients comes with numerous, combinatorial risk factors. Conclusions: Overall, we provide a computational tool that can identify high-risk patients early in their disease progression, which could aid in clinical decision-making and selecting treatment options. url: https://doi.org/10.1101/2020.08.23.20179838 doi: 10.1101/2020.08.23.20179838 id: cord-293167-3bd3adip author: Nepal, Gaurav title: Neurological manifestations of COVID-19: a systematic review date: 2020-07-13 words: 5534.0 sentences: 311.0 pages: flesch: 44.0 cache: ./cache/cord-293167-3bd3adip.txt txt: ./txt/cord-293167-3bd3adip.txt summary: Most patients infected by SARS-CoV-2 have presented with a mild clinical course: beginning with fever and dry cough, progressing to a form of mild or moderate respiratory disease, and resolving without specific treatment [2] . A retrospective observational study from Wuhan, China, reported that six (2.8%) patients, out of the 214 reviewed COVID-19 cases, developed ischemic stroke. A retrospective observational study from a different center in Wuhan, China, found eleven (5.0%) patients, out of 221 reviewed COVID-19 cases, developed acute ischemic stroke. Those who had COVID-19 infection with new onset of ischemic stroke were more likely to have a severe SARS-CoV-2 presentation, an advanced age (71.6 ± 15.7 years versus 52.1 ± 15.3 years), and preexisting cardiovascular risk factors including hypertension, diabetes, and previous cerebrovascular disease. A retrospective observational study from Wuhan, China, reported one (0.45%) patient, out of 221 reviewed COVID-19 cases, who developed intracerebral hemorrhage. abstract: INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within these patients. METHODS: Any study, released prior to May 20, 2020, that reported neurological manifestations in patients infected by SARS-CoV-2 was systematically reviewed using the PRISMA (Preferred Reporting Items for Systemic review and Meta-Analysis) statement. RESULTS: Our systematic review included data from 37 articles: twelve retrospective studies, two prospective studies, and the rest case reports/series. The most commonly reported neurological manifestations of COVID-19 were myalgia, headache, altered sensorium, hyposmia, and hypogeusia. Uncommonly, COVID-19 can also present with central nervous system manifestations such as ischemic stroke, intracerebral hemorrhage, encephalo-myelitis, and acute myelitis, peripheral nervous manifestations such as Guillain-Barré syndrome and Bell’s palsy, and skeletal muscle manifestations such as rhabdomyolysis. CONCLUSION: While COVID-19 typically presents as a self-limiting respiratory disease, it has been reported in up to 20% of patients to progress to severe illness with multi-organ involvement. The neurological manifestations of COVID-19 are not uncommon, but our study found most resolve with treatment of the underlying infection. Although the timeliness of this review engages current challenges posed by the COVID-19 pandemic, readers must not ignore the limitations and biases intrinsic to an early investigation. url: https://www.ncbi.nlm.nih.gov/pubmed/32660520/ doi: 10.1186/s13054-020-03121-z id: cord-307710-dlpfbnb1 author: Neradi, Deepak title: Management of Orthopaedic Patients During COVID-19 Pandemic in India: A Guide date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32341601/ doi: 10.1007/s43465-020-00122-6 id: cord-312846-ef7m4875 author: Nerina, Denaro title: Coronavirus Disease 19 (COVID-19) during chemoradiation for locally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC) date: 2020-05-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.oraloncology.2020.104801 doi: 10.1016/j.oraloncology.2020.104801 id: cord-264779-71s7e18i author: Neumann, Natalie R. title: Medical Toxicology and COVID-19: Our Role in a Pandemic date: 2020-04-30 words: 1930.0 sentences: 114.0 pages: flesch: 42.0 cache: ./cache/cord-264779-71s7e18i.txt txt: ./txt/cord-264779-71s7e18i.txt summary: As medical toxicologists we serve as a fund of knowledge for our healthcare colleagues and the public: we provide physicians with information regarding antidotal therapy, drug-drug interactions, and novel therapeutics. Neumann natalie.neumann@cuanschutz.edu treatment of toxicities born of the use and misuse of approved and alternative therapies is a service our field can readily provide to an otherwise overburdened medical system. Interpreting the nature of end-organ dysfunction as it pertains to therapeutic drug administration and overdose is well within the wheelhouse of medical toxicology and represents both a service our field may provide and a potential research frontier. Lastly, poison centers, historically considered an underutilized source for reporting adverse drug reactions, may be more mindful of tracking and reporting toxicity from novel therapies [26] . Medical experts explain the use and potential adverse effects of chloroquine and hydroxychloroquine for COVID-19 abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32356251/ doi: 10.1007/s13181-020-00778-4 id: cord-329344-06uk5sjp author: Neumann-Podczaska, Agnieszka title: COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review date: 2020-07-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The SARS-CoV-2 tendency to affect the older individuals more severely, raises the need for a concise summary isolating this age population. Analysis of clinical features in light of most recently published data allows for improved understanding, and better clinical judgement. A thorough search was performed to collect all articles published from 1st of January to 1st of June 2020, using the keywords COVID-19 and SARS-CoV-2 followed by the generic terms elderly, older adults or older individuals. The quality assessment of studies and findings was performed by an adaptation of the STROBE statement and CERQual approach. Excluding duplicates, a total of 1598 articles were screened, of which 20 studies were included in the final analysis, pertaining to 4965 older COVID-19 patients (≥60 years old). Variety in symptoms was observed, with fever, cough, dyspnea, fatigue, or sputum production being the most common. Prominent changes in laboratory findings consistently indicated lymphopenia and inflammation and in some cases organ damage. Radiological examination reveals ground glass opacities with occasional consolidations, bilaterally, with a possible peripheral tendency. An evident fraction of the elderly population (25.7%) developed renal injury or impairment as a complication. Roughly 71.4% of the older adults require supplementary oxygen, while invasive mechanical ventilation was required in almost a third of the reported hospitalized older individuals. In this review, death occurred in 20.0% of total patients with a recorded outcome (907/4531). Variability in confidence of findings is documented. Variety in symptom presentation is to be expected, and abnormalities in laboratory findings are present. Risk for mortality is evident, and attention to the need for supplementary oxygen and possible mechanical ventilation is advised. Further data is required isolating this age population. Presented literature may allow for the construction of better predictive models of COVID-19 in older populations. url: https://www.ncbi.nlm.nih.gov/pubmed/32765959/ doi: 10.14336/ad.2020.0620 id: cord-325971-volbaipv author: Neupane, Karun title: Potential Treatment Options for COVID-19: A Comprehensive Review of Global Pharmacological Development Efforts date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease-2019 (COVID-19), first reported in China during December of 2019, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infection later spread very rapidly around the globe with over 8,708,008 cases reported, including more than 461,715 deaths reported across at least 216 countries by June 20, 2020. It was declared as a global pandemic by the World Health Organization (WHO) on March 11, 2020. With the rapidly increasing number of positive cases and deaths, there is a dire need for effective treatment. An urgent unmet need led to the planning and opening of multiple drug development trials for treatment and vaccine development. In this article, we have compiled comprehensive data on many candidate drugs such as remdesivir, favipiravir, ribavirin, umifenovir, arbidol, lopinavir, ritonavir, baricitinib, hydroxychloroquine, nitazoxanide, azithromycin, baloxavir, oseltamivir, losartan, and tocilizumab. We have tabulated available data on various clinical trials testing various aspects of COVID-19 therapeutics. url: https://doi.org/10.7759/cureus.8845 doi: 10.7759/cureus.8845 id: cord-349500-603v8lfb author: Neurath, Markus F title: Covid-19 and immunomodulation in IBD date: 2020-04-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The current coronavirus pandemic is an ongoing global health crisis due to covid-19, caused by severe acute respiratory syndrome coronavirus 2. Although covid-19 leads to little or mild flu-like symptoms in the majority of affected patients, the disease may cause severe, frequently lethal complications such as progressive pneumonia, acute respiratory distress syndrome and organ failure driven by hyperinflammation and a cytokine storm syndrome. This situation causes various major challenges for gastroenterology. In the context of IBD, several key questions arise. For instance, it is an important question to understand whether patients with IBD (eg, due to intestinal ACE2 expression) might be particularly susceptible to covid-19 and the cytokine release syndrome associated with lung injury and fatal outcomes. Another highly relevant question is how to deal with immunosuppression and immunomodulation during the current pandemic in patients with IBD and whether immunosuppression affects the progress of covid-19. Here, the current understanding of the pathophysiology of covid-19 is reviewed with special reference to immune cell activation. Moreover, the potential implications of these new insights for immunomodulation and biological therapy in IBD are discussed. url: https://doi.org/10.1136/gutjnl-2020-321269 doi: 10.1136/gutjnl-2020-321269 id: cord-343877-jzkaee16 author: Newdick, Chris title: Tragic choices in intensive care during the COVID-19 pandemic: on fairness, consistency and community date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Tragic choices arise during the COVID-19 pandemic when the limited resources made available in acute medical settings cannot be accessed by all patients who need them. In these circumstances, healthcare rationing is unavoidable. It is important in any healthcare rationing process that the interests of the community are recognised, and that decision-making upholds these interests through a fair and consistent process of decision-making. Responding to recent calls (1) to safeguard individuals’ legal rights in decision-making in intensive care, and (2) for new authoritative national guidance for decision-making, this paper seeks to clarify what consistency and fairness demand in healthcare rationing during the COVID-19 pandemic, from both a legal and ethical standpoint. The paper begins with a brief review of UK law concerning healthcare resource allocation, considering how community interests and individual rights have been marshalled in judicial deliberation about the use of limited health resources within the National Health Service (NHS). It is then argued that an important distinction needs to be drawn between procedural and outcome consistency, and that a procedurally consistent decision-making process ought to be favoured. Congruent with the position that UK courts have adopted for resource allocation decision-making in the NHS more generally, specific requirements for a procedural framework and substantive triage criteria to be applied within that framework during the COVID-19 pandemic are considered in detail. url: https://www.ncbi.nlm.nih.gov/pubmed/32769095/ doi: 10.1136/medethics-2020-106487 id: cord-344939-rgxqobfw author: Ng, C. W. Q. title: Maintaining breast cancer care in the face of COVID‐19 date: 2020-08-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The battle of COVID‐19 is currently at different levels of intensity in each country and even each city. The authors have prepared succinct recommendations regarding the care of patients with breast cancer, divided into phases that can easily be adapted to each units' needs and resources, and stepped up or stepped down according to escalating and de‐escalating circumstances. The structure can also be transposed easily to different cancer types, enabling continued provision of best standards of care despite unprecedented stressors. [Image: see text] Surgery must go on url: https://www.ncbi.nlm.nih.gov/pubmed/32880908/ doi: 10.1002/bjs.11835 id: cord-316067-mlcczr8c author: Ng, Jia H. title: Outcomes of patients with end-stage kidney disease hospitalized with COVID-19 date: 2020-08-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Given the high risk of infection-related mortality, patients with end-stage kidney disease (ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of patients with and without ESKD, hospitalized with COVID-19. This was a retrospective study of patients admitted with COVID-19 from 13 New York. hospitals from March 1, 2020, to April 27, 2020, and followed through May 27, 2020. We measured primary outcome (in-hospital death), and secondary outcomes (mechanical ventilation and length of stay), Of 10,482 patients with COVID-19, 419 had ESKD. Patients with ESKD were older, had a greater percentage self-identified as Black, and more comorbid conditions. Patients with ESKD had a higher rate of in-hospital death than those without (31.7% vs 25.4%, odds ratio 1.38, 95% confidence interval 1.12 - 1.70). This increase rate remained after adjusting for demographic and comorbid conditions (adjusted odds ratio 1.37, 1.09 - 1.73). The odds of length of stay of seven or more days was higher in the group with compared to the group without ESKD in both the crude and adjusted analysis (1.62, 1.27 - 2.06; vs 1.57, 1.22 - 2.02, respectively). There was no difference in the odds of mechanical ventilation between the groups. Independent risk factors for in-hospital death for patients with ESKD were increased age, being on a ventilator, lymphopenia, blood urea nitrogen and serum ferritin. Black race was associated with a lower risk of death. Thus, among patients hospitalized with COVID-19, those with ESKD had a higher rate of in-hospital death compared to those without ESKD. url: https://www.sciencedirect.com/science/article/pii/S0085253820309455?v=s5 doi: 10.1016/j.kint.2020.07.030 id: cord-342810-41dghl0c author: Nguyen, Thanh N. title: Subarachnoid hemorrhage guidance in the era of the COVID-19 pandemic -An opinion to mitigate exposure and conserve personal protective equipment date: 2020-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Aneurysmal subarachnoid hemorrhage (SAH) patients require frequent neurological examinations, neuroradiographic diagnostic testing and lengthy intensive care unit stay. Previously established SAH treatment protocols are impractical to impossible to adhere to in the current COVID-19 crisis due to the need for infection containment and shortage of critical care resources, including personal protective equipment (PPE). Centers need to adopt modified protocols to optimize SAH care and outcomes during this crisis. In this opinion piece, we assembled a multidisciplinary, multicenter team to develop and propose a modified guidance algorithm that optimizes SAH care and workflow in the era of the COVID-19 pandemic. This guidance is to be adapted to the available resources of a local institution and does not replace clinical judgment when faced with an individual patient. url: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105010 doi: 10.1016/j.jstrokecerebrovasdis.2020.105010 id: cord-000904-g6ffaer1 author: Ni, Hong title: Sorafenib Combined with Cryoablation to Treat Unresectable Hepatocellular Carcinoma date: 2011-09-17 words: 3449.0 sentences: 186.0 pages: flesch: 46.0 cache: ./cache/cord-000904-g6ffaer1.txt txt: ./txt/cord-000904-g6ffaer1.txt summary: OBJECTIVE: To evaluate the efficacy and tolerability of sorafenib combined with cryoablation in treating unresectable hepatocellular carcinoma (HCC). METHODS: Patients with unresectable advanced HCC received cryoablation and sorafenib at a dose of 400 mg twice daily in 4-week cycles on the same day of the cryoablation. CONCLUSION: Cryoablation combined with sorafenib demonstrates good efficacy and acceptable tolerability in treating unresectable advanced HCC patients. Among patients with advanced disease who do not qualify for surgical or liver transplantation therapies, the only non-chemotherapeutic treatment that has been shown to increase survival is sorafenib [6] . In this paper, we report the results of our prospective study conducted to evaluate the efficacy and acceptable tolerability of sorafenib as adjuvant treatment after cryoablation in the treatment of unresectable HCC. However, all other patients and tumor characteristics, including age, sex, ECOG performance status, Child-Pugh class, ongoing antiviral therapy, BCLC stage, and prior systemic treatment had no effect on clinical benefits. abstract: OBJECTIVE: To evaluate the efficacy and tolerability of sorafenib combined with cryoablation in treating unresectable hepatocellular carcinoma (HCC). METHODS: Patients with unresectable advanced HCC received cryoablation and sorafenib at a dose of 400 mg twice daily in 4-week cycles on the same day of the cryoablation. Tumor response, median overall survival and the median time to radiological progression were calculated and the toxicity was evaluated. RESULTS: Seventy-eight patients with unresectable HCC were involved in this study. The median age was 52 years (range, 22-81 years). The Eastern Cooperative Oncology Group (ECOG) performance status scores were 0 (39.7%), 1 (55.1%), and 2 (5.1%). Nine (11.5%) patients were at Barcelona clinic liver cancer (BCLC) stage A, twenty-four (30.8%) patients were at stage B and 45 (57.7%) patients were at stage C. Five (6.4%) achieved partial responses, and 34 (43.6%) achieved stable disease. The median time to progression (TTP) for all enrolled patients was 6.6 months and the median overall survival (OS) was 12.2 months. CONCLUSION: Cryoablation combined with sorafenib demonstrates good efficacy and acceptable tolerability in treating unresectable advanced HCC patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587556/ doi: 10.1007/s11670-011-0188-y id: cord-325783-pqonn0as author: Nicholls, John M title: Lung pathology of fatal severe acute respiratory syndrome date: 2003-05-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Severe acute respiratory syndrome (SARS) is a novel infectious disease with global impact. A virus from the family Coronaviridae has been identified as the cause, but the pathogenesis is still unclear. METHODS: Post-mortem tissue samples from six patients who died from SARS in February and March, 2003, and an open lung biopsy from one of these patients were studied by histology and virology. Only one full autopsy was done. Evidence of infection with the SARS-associated coronavirus (SARS-CoV) and human metapneumovirus was sought by reverse-transcriptase PCR and serology. Pathological samples were examined by light and electron microscopy and immunohistochemistry. FINDINGS: All six patients had serological evidence of recent infection with SARS-CoV. Diffuse alveolar damage was common but not universal. Morphological changes identified were bronchial epithelial denudation, loss of cilia, and squamous metaplasia. Secondary bacterial pneumonia was present in one case. A giant-cell infiltrate was seen in four patients, with a pronounced increase in macrophages in the alveoli and the interstitium of the lung. Haemophagocytosis was present in two patients. The alveolar pneumocytes also showed cytomegaly with granular amphophilic cytoplasm. The patient for whom full autopsy was done had atrophy of the white pulp of the spleen. Electron microscopy revealed viral particles in the cytoplasm of epithelial cells corresponding to coronavirus. INTERPRETATION: SARS is associated with epithelial-cell proliferation and an increase in macrophages in the lung. The presence of haemophagocytosis supports the contention that cytokine dysregulation may account, at least partly, for the severity of the clinical disease. The case definition of SARS should acknowledge the range of lung pathology associated with this disease. Published online May 16, 2003 http://image.thelancet.com/extras/03art4347web.pdf url: https://www.sciencedirect.com/science/article/pii/S0140673603134137 doi: 10.1016/s0140-6736(03)13413-7 id: cord-313989-bc7q8swu author: Nicholls, Stephen J. title: Optimising Secondary Prevention and Cardiac Rehabilitation for Atherosclerotic Cardiovascular Disease During the COVID-19 Pandemic: A Position Statement from the Cardiac Society of Australia and New Zealand (CSANZ) # date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has introduced a major disruption to the delivery of routine health care across the world. This provides challenges for the use of secondary prevention measures in patients with established atherosclerotic cardiovascular disease (CVD). The aim of this Position Statement is to review the implications for effective delivery of secondary prevention strategies during the COVID-19 pandemic. Challenges The COVID-19 pandemic has introduced limitations for many patients to access standard health services such as visits to health care professionals, medications, imaging and blood tests as well as attendance at cardiac rehabilitation. In addition, the pandemic is having an impact on lifestyle habits and mental health. Taken together, this has the potential to adversely impact the ability of practitioners and patients to adhere to treatment guidelines for the prevention of recurrent cardiovascular events. Recommendations Every effort should be made to deliver safe ongoing access to health care professionals and the use of evidenced based therapies in individuals with CVD. An increase in use of a range of electronic health platforms has the potential to transform secondary prevention. Integrating research programs that evaluate the utility of these approaches may provide important insights into how to develop more optimal approaches to secondary prevention beyond the pandemic. url: https://www.sciencedirect.com/science/article/pii/S1443950620301359?v=s5 doi: 10.1016/j.hlc.2020.04.007 id: cord-322104-f1dukpso author: Niederman, M.S. title: PNEUMONIA | Community Acquired Pneumonia, Bacterial and Other Common Pathogens date: 2006-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Community-acquired pneumonia (CAP) is the number one cause of death from infectious diseases in the US, and the patient population that is affected is becoming increasingly more complex due to the presence of chronic illness which is commonly managed in outpatients who are at risk for pneumonia. The number one pathogen causing CAP is pneumococcus, which is commonly resistant to multiple antibiotics, thus complicating management. Other common pathogens include atypical organisms (Chlamydophila pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae), Hemophilus influenzae, enteric Gram-negatives (especially in those with chronic illness and aspiration risk factors), and Staphylococcus aureus. Successful management requires careful assessment of disease severity so that a site-of-care decision can be made (outpatient, inpatient, intensive care unit), appropriate samples for diagnostic testing collected, and antibiotic therapy initiated in a timely and accurate fashion. Initial antibiotic therapy is empiric, but even with extensive diagnostic testing, less than half of all patients have an etiologic pathogen identified. All patients with CAP require therapy for pneumococcus, atypical pathogens, and other organisms, as dictated by the presence of specific risk factors. Because pneumonia has both short-term and long-term impact on mortality, it is also important to focus on prevention of this illness, which requires smoking cessation, and giving at-risk individuals both pneumococal and influenza vaccines. url: https://api.elsevier.com/content/article/pii/B0123708796003100 doi: 10.1016/b0-12-370879-6/00310-0 id: cord-276635-0ciy732e author: Nijjer, Sukhjinder Singh title: Optimal management of acute coronary syndromes in the era of COVID-19 date: 2020-09-02 words: 4483.0 sentences: 279.0 pages: flesch: 48.0 cache: ./cache/cord-276635-0ciy732e.txt txt: ./txt/cord-276635-0ciy732e.txt summary: While PPCI remains the treatment of choice for STEMI, the number of COVID-19 cases in Wuhan and Lombardy raised sufficient concerns that thrombolysis should be considered in certain circumstances. Low-risk patients with low Global Registry of Acute Coronary Events (GRACE) scores and small troponin-rises can be stratified, and if appropriate, then early urgent angiography can be considered on an ''outpatient'' basis without inpatient stays. The treatment for ACS is well established, and while Key points ► Prompt and early revascularisation, with appropriate personal protective equipment, remains the default treatment approach for patients with acute coronary syndrome in the COVID-19 era. ► Critically unwell patients with ST-elevation myocardial infarction, without onsite catheter lab facilities or too unstable for transfer should be considered for thrombolysis and activation of services for facilitated PCI if necessary. Effect of the COVID-19 pandemic on ST-segment-elevation myocardial infarction presentations and in-hospital outcomes abstract: nan url: https://doi.org/10.1136/heartjnl-2020-317143 doi: 10.1136/heartjnl-2020-317143 id: cord-316135-kevyw19w author: Nikoupour, Hamed title: Pediatric liver transplantation and COVID-19: a case report date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Immunosuppressed patients, including individuals with organ transplantation, have been among susceptible groups with regard to COVID-19, on the other hand pediatric patients more commonly undergo a mild clinical course after acquiring COVID-19. To the best of the authors knowledge, to this date very little data exists on COVID-19 in a pediatric patient with liver transplantation. CASE PRESENTATION: We report a three year-old boy who had liver transplantation at 18 months old. He was admitted due to dyspnea with impression of acute respiratory distress syndrome and was then transferred to the intensive care unit. Chest X-ray at admission showed bilateral infiltration. Vancomycin, meropenem, azithromycin, voriconazole and co-trimoxazole were started from the first day of admission. On day 4 of admission, with suspicion of COVID-19, hydroxychloroquine, lopinavir/ritonavir and oseltamivir were added to the antibiotic regimen. PCR was positive for COVID-19. The patient developed multi-organ failure and died on day 6 of admission. CONCLUSIONS: For pediatric patients with organ transplantations, extreme caution should be taken, to limit and prevent their contact with COVID-19 during the outbreak, as these patients are highly susceptible to severe forms of the disease. url: https://doi.org/10.1186/s12893-020-00878-6 doi: 10.1186/s12893-020-00878-6 id: cord-269205-g6eyvnou author: Nilsen, Marci Lee title: Prevision of multidisciplinary head and neck cancer survivorship care during the 2019 novel coronavirus pandemic date: 2020-05-18 words: 3828.0 sentences: 186.0 pages: flesch: 46.0 cache: ./cache/cord-269205-g6eyvnou.txt txt: ./txt/cord-269205-g6eyvnou.txt summary: These guidelines address five key areas: (a) surveillance for recurrence, (b) screening for second primary cancers, (c) assessment and management of physical and psychosocial effects of cancer and treatment, (d) health promotion, and (e) care coordination. Based on the PROs and patient assessment, the visit is personalized to provide an evaluation of recurrence, prevention of second primaries, identification of treatment-effects, and, subsequently, coordination of care. The COVID-19 pandemic has led to changes in medical oncology and radiation oncology care, including surveillance after completion of treatment, in an effort to still provide the care needed, but also reduce risks as much as possible. Prior to the COVID pandemic, our goal as a head and neck program has been to offer at least one visit with medical oncology and radiation oncology at the primary cancer center in order to help develop the plan and offer clinical trials if applicable for all patients. abstract: The 2019 Coronavirus Pandemic challenges the delivery of care for patients with head and neck cancer. An important aspect of this care has been the evolution of enhanced survivorship services, which include surveillance for recurring cancer and prevention of second primaries. The application of evidence‐based approaches to the identification and management of treatment and tumor‐related toxicities has embraced the use of validated patient‐reported outcomes instruments, health promotion, and care coordination. In this manuscript, we describe how our multidisciplinary team of survivorship providers has accommodated to the need to provide patients with social distancing while acknowledging the importance of continued care during treatment and through the spectrum of survivorship. url: https://doi.org/10.1002/hed.26256 doi: 10.1002/hed.26256 id: cord-032183-yqqqe325 author: Ning, Qin title: Antiviral Therapy for AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 words: 32675.0 sentences: 1658.0 pages: flesch: 43.0 cache: ./cache/cord-032183-yqqqe325.txt txt: ./txt/cord-032183-yqqqe325.txt summary: Patients awaiting liver transplantation because of HBV-related end-stage liver disease or liver cancer should be given nucleoside analogues with strong HBV inhibition and low drug-resistance, or nucleotides analogues combination treatment, in order to reduce viral load and prevent graft re-infection. The objective of antiviral treatment for HBV-ACLF is to reduce viral load at an appreciably high rate, thereby promoting reduction in hepatocyte cell death and improved survival outcomes by prevention of decompensation related multiorgan complications in this group of severely ill patients. Response-Guided Therapy 4006 study [126] suggested continuous treatment with LAM (10 years) delayed clinical progression in patients with chronic hepatitis and advanced fibrosis by significantly reducing the incidence of the risk of hepatocellular carcinoma and hepatic decompensation. abstract: This chapter describes the principles of antiviral therapy, treatment strategies, medications and recommendations for AECHB, HBV-ACLF, HBV-related liver cirrhosis, HBV-related HCC, and liver transplantation. 1. Severe exacerbation of chronic hepatitis B is closely related to continuous HBV replication. Therefore, inhibiting HBV replication to reduce viral load may block disease progression and improve the quality of life of these patients. ETV or TDF has been recommend first-line drug for the treatment of AECHB. 2. A hyperactive immune response due to continuous HBV replication is the main mechanism for development of severe hepatitis B. In addition to comprehensive treatment, early administration of potent nucleoside analogs can rapidly reduce HBV DNA concentration, relieve immune injury induced by HBV, and reduce liver inflammation and patient mortality. Antiviral agents have become important in the treatment of severe exacerbation of chronic hepatitis B. 3. Long-term antiviral treatment with nucleoside analogs can delay or reverse the progress of liver cirrhosis. Virologic response, viral resistance and adverse drug reactions should be closely monitored during treatment. The treatment should be optimized for maximum effect based on each patient’s responses. 4. Effective antiviral therapy can suppress HBV replication and reduce the incidence of HBV-related HCC. Patients with HBV-related HCC should receive individualized and optimal multidisciplinary comprehensive treatment. Anti-viral drugs with high efficacy, low resistance and low adverse drug reactions should be selected to improve the patient’s quality of life and prolong survival time. 5. Methods to prevent HBV reinfection after liver transplantation include passive immunization (HBIG), antiviral treatment (nucleoside analogs) and active immunization (hepatitis B vaccine). 6. Clinical trials involving sequential combination therapy with NUC and Peg-IFN have shown statistically significant decline in HBsAg levels on treatment and high rates of sustained post-treatment serologic response. Combination therapy with novel DAA and immunotherapeutic approach may hold promise to overcome both cccDNA persistence and immune escape, representing a critical step towards HBV cure. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498919/ doi: 10.1007/978-94-024-1603-9_5 id: cord-340576-dabcs3w5 author: Nishikawa, Hiroki title: Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis date: 2020-07-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Sarcopenia in patients with liver cirrhosis (LC) has been attracting much attention these days because of the close linkage to adverse outcomes. LC can be related to secondary sarcopenia due to protein metabolic disorders and energy metabolic disorders. LC is associated with profound alterations in gut microbiota and injuries at the different levels of defensive mechanisms of the intestinal barrier. Dysbiosis refers to a state in which the diversity of gut microbiota is decreased by decreasing the bacterial species and the number of bacteria that compose the gut microbiota. The severe disturbance of intestinal barrier in LC can result in dysbiosis, several bacterial infections, LC-related complications, and sarcopenia. Here in this review, we will summarize the current knowledge of the relationship between sarcopenia and dysbiosis in patients with LC. url: https://www.ncbi.nlm.nih.gov/pubmed/32722100/ doi: 10.3390/ijms21155254 id: cord-028721-x6f26ahr author: Nistal, Manuel title: Non-neoplastic diseases of the testis date: 2020-06-22 words: 78172.0 sentences: 5138.0 pages: flesch: 41.0 cache: ./cache/cord-028721-x6f26ahr.txt txt: ./txt/cord-028721-x6f26ahr.txt summary: Congenital decrease of germ cells occurs in numerous conditions, including trisomies 13, 18, and 21, some forms of primary hypogonadism such as Klinefelter''s syndrome, anencephaly, many cryptorchid testes, and in patients with posterior urethral valves and severe obstruction of the urinary ducts. 728, 729 Leydig cell hypoplasia This variant of male pseudohermaphroditism is defi ned by insuffi cient testosterone secretion 422 and the following characteristics: predominance of female external genitalia; absence of male secondary sex characteristics at puberty; absence of uterus and fallopian tubes and the presence of epididymis and vas deferens; 46XY karyotype; lack of response to human chorionic gonadotropin stimulation; absence of an enzymatic defect in testosterone synthesis; and small undescended testes that are gray and mucous on section. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339753/ doi: 10.1016/b978-0-323-01970-5.50014-2 id: cord-344668-9m1vnpmo author: Nitkunan, Arani title: COVID-19: switching to remote neurology outpatient consultations date: 2020-05-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32366596/ doi: 10.1136/practneurol-2020-002571 id: cord-330431-9txstz4n author: Nomikos, Iakovos N title: What Else but Covid-19 Pandemic? Lessons Learned date: 2020-07-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32834090/ doi: 10.1007/s13126-020-0544-9 id: cord-288697-9dywuhkc author: Noone, Rachel title: LETTER TO THE EDITOR: NEW ONSET PSYCHOSIS AND MANIA FOLLOWING COVID-19 INFECTION date: 2020-08-08 words: 1312.0 sentences: 87.0 pages: flesch: 49.0 cache: ./cache/cord-288697-9dywuhkc.txt txt: ./txt/cord-288697-9dywuhkc.txt summary: Here we present two case reports of adult patients with COVID-19 infections who presented with severe psychosis and mania with no prior psychiatric history and in the absence of significant medical or pulmonary symptoms and an unremarkable neurological work-up. Clinical presentation: Patient-A presented with one week of insomnia and two days of altered behavior including confusion, decreased appetite, and grandiosity and making odd statements. Three weeks prior to his ED admission, Patient-A was diagnosed with presumed COVID-19, treated with oral azithromycin, and told to self-quarantine. J o u r n a l P r e -p r o o f These cases illustrate an association of neuropsychiatric symptoms with COVID-19 infection, in the absence of personal or family history of psychiatric illness, as well as the absence of hypoxemia, cerebral infarction or significant pulmonary involvement. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32823051/ doi: 10.1016/j.jpsychires.2020.07.042 id: cord-314152-wd153s1g author: Noor, Farha Musharrat title: Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis date: 2020-09-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The main aim of this study was to find the prevalence of mortality among hospitalized COVID-19 infected patients and associated risk factors for death. METHODS: Three electronic databases including PubMed, Science Direct and Google Scholar were searched to identify relevant cohort studies of COVID-19 disease from January 1, 2020, to August 11, 2020. A random-effects model was used to calculate pooled prevalence rate (PR), risk ratio (RR) and 95% confidence interval (CI) for both effect measures. Cochrane chi-square test statistic Q, [Formula: see text] , and [Formula: see text] tests were used to measure the presence of heterogeneity. Publication bias and sensitivity of the included studies were also tested. RESULTS: In this meta-analysis, a total of 58 studies with 122,191 patients were analyzed. The pooled prevalence rate of mortality among the hospitalized COVID-19 patients was 18.88%, 95% CI (16.46–21.30), p < 0.001. Highest mortality was found in Europe [PR 26.85%, 95% CI (19.41–34.29), p < 0.001] followed by North America [PR 21.47%, 95% CI (16.27–26.68), p < 0.001] and Asia [PR 14.83%, 95% CI (12.46- 17.21), p < 0.001]. An significant association were found between mortality among COVID-19 infected patients and older age (> 65 years vs. < 65 years) [RR 3.59, 95% CI (1.87–6.90), p < 0.001], gender (male vs. female) [RR 1.63, 95% CI (1.43–1.87), p < 0.001], ICU admitted patients [RR 3.72, 95% CI (2.70–5.13), p < 0.001], obesity [RR 2.18, 95% CI (1.10–4.34), p < 0.05], hypertension [RR 2.08,95% CI (1.79–2.43) p < 0.001], diabetes [RR 1.87, 95% CI (1.23–2.84), p < 0.001], cardiovascular disease [RR 2.51, 95% CI (1.20–5.26), p < 0.05], and cancer [RR 2.31, 95% CI (1.80–2.97), p < 0.001]. In addition, significant association for high risk of mortality were also found for cerebrovascular disease, COPD, coronary heart disease, chronic renal disease, chronic liver disease, chronic lung disease and chronic kidney disease. CONCLUSION: This meta-analysis revealed that the mortality rate among COVID-19 patients was highest in the European region and older age, gender, ICU patients, patients with comorbidity had a high risk for case fatality. Those findings would help the health care providers to reduce the mortality rate and combat this pandemic to save lives using limited resources. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10900-020-00920-x) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s10900-020-00920-x doi: 10.1007/s10900-020-00920-x id: cord-339695-3ij5pjjy author: Nopp, Stephan title: Risk of venous thromboembolism in patients with COVID‐19: A systematic review and meta‐analysis date: 2020-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Venous thromboembolism (VTE) is frequently observed in patients with coronavirus disease 2019 (COVID‐19). However, reported VTE‐rates differ substantially. OBJECTIVES: We aimed at evaluating available data and estimating the prevalence of VTE in COVID‐19 patients. METHODS: We conducted a systematic literature search (MEDLINE, EMBASE, WHO COVID‐19 database) to identify studies reporting VTE‐rates in COVID‐19 patients. Studies with suspected high risk of bias were excluded from quantitative synthesis. Pooled outcome rates were obtained within a random effects meta‐analysis. Subgroup analyses were performed for different settings (intensive care unit (ICU) vs. non‐ICU hospitalization and screening vs. no screening) and the association of D‐dimer levels and VTE‐risk was explored. RESULTS: Eighty‐six studies (33,970 patients) were identified and 66 (28,173 patients, mean age: 62.6 years, 60% men, 20% ICU‐patients) were included in quantitative analysis. The overall VTE‐prevalence estimate was 14.1% (95%CI 11.6‐16.9), 40.3% (95%CI 27.0‐54.3) with ultrasound‐screening and 9.5% (95%CI 7.5‐11.7) without screening. Subgroup analysis revealed high heterogeneity, with a VTE‐prevalence of 7.9% (95%CI 5.1‐11.2) in non‐ICU and 22.7% (95%CI 18.1‐27.6) in ICU patients. Prevalence of pulmonary embolism (PE) in non‐ICU and ICU patients was 3.5% (95%CI 2.2‐5.1) and 13.7% (95%CI 10.0‐17.9). Patients developing VTE had higher D‐dimer levels (weighted mean difference 3.26 µg/ml (95%CI 2.76‐3.77) than non‐VTE patients. CONCLUSION: VTE occurs in 22.7% of patients with COVID‐19 in the ICU, but VTE risk is also increased in non‐ICU hospitalized patients. Patients developing VTE had higher D‐dimer levels. Studies evaluating thromboprophylaxis strategies in patients with COVID‐19 are needed to improve prevention of VTE. url: https://www.ncbi.nlm.nih.gov/pubmed/33043231/ doi: 10.1002/rth2.12439 id: cord-274871-jlquvz51 author: Nori, Priya title: Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge date: 2020-07-24 words: 2205.0 sentences: 132.0 pages: flesch: 40.0 cache: ./cache/cord-274871-jlquvz51.txt txt: ./txt/cord-274871-jlquvz51.txt summary: title: Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge We observed bacterial or fungal coinfections in COVID-19 patients admitted between March 1 and April 18, 2020 (152 of 4,267, 3.6%). Few studies have addressed bacterial or fungal coinfections or the emergence of antimicrobial resistance in coronavirus disease 2019 (COVID-19) patients. Patient demographics, central venous catheter status, ICU status, mechanical ventilation status, imaging, laboratory results, administered antibiotics per days of therapy (DOT), and disposition (admitted, discharged, deceased) were obtained from the electronic medical record. We observed widespread empiric antibiotic use throughout the pandemic and clinically relevant bacterial and fungal coinfections in patients with advanced COVID-19 and multiple risk factors for nosocomial infection (mechanical ventilation, central venous catheters, treatment with corticosteroids or biologics, and prolonged hospitalization). 2,6 Moreover, 79% of coinfected patients received antibiotics in the 30 days preceding positive cultures and 98% received them during the index COVID-19 hospitalization. abstract: We observed bacterial or fungal coinfections in COVID-19 patients admitted between March 1 and April 18, 2020 (152 of 4,267, 3.6%). Among these patients, mortality was 57%; 74% were intubated; 51% with bacteremia had central venous catheters. Time to culture positivity was 6–7 days, and 79% had received prior antibiotics. Metallo-β-lactamase–producing E. cloacae coinfections occurred in 5 patients. url: https://doi.org/10.1017/ice.2020.368 doi: 10.1017/ice.2020.368 id: cord-006864-t5qsjyfi author: Norris, S. title: National scientific medical meeting 1995 abstracts: Oral presentations date: 1995 words: 36469.0 sentences: 2072.0 pages: flesch: 53.0 cache: ./cache/cord-006864-t5qsjyfi.txt txt: ./txt/cord-006864-t5qsjyfi.txt summary: 28 patients with RA were studied prospectively by measuring disease activity and radiological articular destruction at entry and at review 6 (mean) (range 4-8) years later. We document its occurrence in the paediatric age group with 3 case reports of tinea unguium occurring in healthy children, ages ranging from 7 to 14 years from different families, presenting over a 6 month period. The first group (the study group, n=20) consisted of patients attending ophthalmic clinics with a diagnosis of early open angle glaucoma who are on medical treatment with good control of intraocular pressure, evidence of optic disc cupping and no field loss on KOWA fields. In this study, 12 outpatients having Dementia of the Alzheimer Type (Clinical Dementia Rating, Score ~ 1 ; mean age _+ SEM, 74 + 2 years) were continuously monitored using Finapress and their responses to the Valsalva manoeuvre and positional change were compared with 12 age matched (73 _+ 1 years) healthy elderly controls. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103225/ doi: 10.1007/bf02967283 id: cord-309214-v2iqgjc4 author: Nougier, Christophe title: Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Thirty percent of Covid‐19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed resting, obesity, hypoxia, coagulopathy, acute excessive inflammation are potential mechanisms reported by previous studies. Better understanding of the underlying mechanisms leading to thrombosis is crucial for developing more appropriate prophylaxis and treatment strategies. OBJECTIVE: We aimed to assess fibrinolytic activity and thrombin generation in 78 Covid‐19 patients. PATIENTS AND METHODS: Forty eight patients admitted to intensive care unit (ICU) and 30 patients admitted to the internal medicine department were included in the study. All patients received thromboprophylaxis. We measured fibrinolytic parameters (tPA, PAI‐1, TAFI, alpha2 anti‐plasmin, and tPA‐modified ROTEM), thrombin generation, and other coagulation tests (D‐dimer, fibrinogen, FVIII, antithrombin). RESULTS AND CONCLUSIONS: We observed two key findings: a high thrombin generation capacity which remained within normal values despite heparin therapy and a hypofibrinolysis mainly associated with increased PAI‐1 levels. A modified ROTEM (TEM‐tPA) is able to detect both hypercoagulability and hypofibrinolysis simultaneously in Covid‐19 patients with thrombosis. url: https://www.ncbi.nlm.nih.gov/pubmed/32668058/ doi: 10.1111/jth.15016 id: cord-354411-4emzxu09 author: Nouvenne, Antonio title: Lung Ultrasound in COVID-19 Pneumonia: Correlations with Chest CT on Hospital admission date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Lung ultrasound (LUS) is an accurate, safe, and cheap tool assisting in the diagnosis of several acute respiratory diseases. The diagnostic value of LUS in the workup of coronavirus disease-19 (COVID-19) in the hospital setting is still uncertain. OBJECTIVES: The aim of this observational study was to explore correlations of the LUS appearance of COVID-19-related pneumonia with CT findings. METHODS: Twenty-six patients (14 males, age 64 ± 16 years) urgently hospitalized for COVID-19 pneumonia, who underwent chest CT and bedside LUS on the day of admission, were enrolled in this observational study. CT images were reviewed by expert chest radiologists, who calculated a visual CT score based on extension and distribution of ground-glass opacities and consolidations. LUS was performed by clinicians with certified competency in thoracic ultrasonography, blind to CT findings, following a systematic approach recommended by ultrasound guidelines. LUS score was calculated according to presence, distribution, and severity of abnormalities. RESULTS: All participants had CT findings suggestive of bilateral COVID-19 pneumonia, with an average visual scoring of 43 ± 24%. LUS identified 4 different possible ­abnormalities, with bilateral distribution (average LUS score 15 ± 5): focal areas of nonconfluent B lines, diffuse confluent B lines, small subpleural microconsolidations with pleural line irregularities, and large parenchymal consolidations with air bronchograms. LUS score was significantly correlated with CT visual scoring (r = 0.65, p < 0.001) and oxygen saturation in room air (r = −0.66, p < 0.001). CONCLUSION: When integrated with clinical data, LUS could represent a valid diagnostic aid in patients with suspect COVID-19 pneumonia, which reflects CT findings. url: https://doi.org/10.1159/000509223 doi: 10.1159/000509223 id: cord-287538-qbf5lv7d author: Nucera, Eleonora title: Latex Allergy: Current Status and Future Perspectives date: 2020-09-28 words: 6676.0 sentences: 354.0 pages: flesch: 42.0 cache: ./cache/cord-287538-qbf5lv7d.txt txt: ./txt/cord-287538-qbf5lv7d.txt summary: The following eligibility criteria were used for article inclusion: population: patients with latex allergy and/or at risk for anaphylaxis; intervention: any approaches or protocols that incorporated a strategy for latex allergy and anaphylaxis management; comparator: any studies irrespective of whether there was a comparator included in the study design; outcomes: any related to prevalence, diagnostics, and treatments including primary prevention and immunotherapy; and study design: experimental studies and observational studies. 65 On the other hand, only a small case series of nine patients has described the efficacy of accelerator-free medical gloves in the secondary prevention of allergic contact dermatitis (ACD) caused by rubber accelerators in HCWs. 66 Gentili et al 67 showed that an effective and exemplary example of secondary prevention of latex allergy is feasible for infants born with spina bifida. abstract: Allergy to natural rubber latex (NRLA) from Hevea brasiliensis is a relevant public health issue, in particular in healthcare workers and groups at risk. Clinical manifestations of NRLA can range from mild skin disorders to life-threatening systemic reactions. Prevention measures remain the gold-standard treatment for patients suffering from NRLA, but the only etiological therapy able to influence the natural history of NRLA is specific desensitization. This review aims to underline the epidemiological, clinical and diagnostic aspects of NRLA, and carries out a complete and wide-ranging review of the current literature on NRLA management and immunotherapy. url: https://doi.org/10.2147/jaa.s242058 doi: 10.2147/jaa.s242058 id: cord-348879-opzkodt7 author: Nune, A. title: Challenges in delivering rheumatology care during COVID-19 pandemic date: 2020-07-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 has significantly affected healthcare systems around the world. To prepare for this unprecedented emergency, elective patient care was put on hold across the National Health Service (NHS). Rheumatology service had to be reorganised with a cancellation of elective clinics and clinical reconfiguration to continue to deliver care to patients, support frontline, and prevent viral transmission. The rheumatology community’s responsibility of providing a continuity of care for patients had to be balanced with measures to reduce the risk of viral transmission and also protection of both the patients and staff. We describe our experience of delivering rheumatology service as recommended by the National Institute for Health and Care Excellence (NICE NG167) guidelines at a district general hospital during the current pandemic. url: https://doi.org/10.1007/s10067-020-05312-z doi: 10.1007/s10067-020-05312-z id: cord-034746-uxhpufnv author: Nusshag, Christian title: Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date: 2020-11-05 words: 3642.0 sentences: 194.0 pages: flesch: 36.0 cache: ./cache/cord-034746-uxhpufnv.txt txt: ./txt/cord-034746-uxhpufnv.txt summary: We therefore analyzed standard markers of glomerular proteinuria (e.g. immunoglobulin G [IgG]), urinary nephrin excretion (podocyte injury) and serum levels of the soluble urokinase plasminogen activator receptor (suPAR), a proposed pathomechanically involved molecule in INS, in PUUV-infected patients. On admission, patients suffering from hantavirus infection showed significantly increased urinary nephrin, IgG, α1-MG and serum suPAR levels compared to healthy controls (Fig. 3A ). Though, urinary biomarker levels decreased in both groups over time, patients with severe PCR showed significantly higher levels of nephrin, IgG, ACR and PCR during the first 48 h after admission ( Table 2 ). Our data show a strong association between urinary nephrin levels and the extent of (non-selective) glomerular proteinuria, suggesting that hantavirus infection causes a pronounced podocyte damage and subsequent impairment of the GFB. To date, one other study showed significantly elevated blood suPAR levels and their association with hantavirus disease severity but did not include nephrinuria and the extent of proteinuria in their analysis 19 . abstract: Podocyte injury has recently been described as unifying feature in idiopathic nephrotic syndromes (INS). Puumala hantavirus (PUUV) infection represents a unique RNA virus-induced renal disease with significant proteinuria. The underlying pathomechanism is unclear. We hypothesized that PUUV infection results in podocyte injury, similar to findings in INS. We therefore analyzed standard markers of glomerular proteinuria (e.g. immunoglobulin G [IgG]), urinary nephrin excretion (podocyte injury) and serum levels of the soluble urokinase plasminogen activator receptor (suPAR), a proposed pathomechanically involved molecule in INS, in PUUV-infected patients. Hantavirus patients showed significantly increased urinary nephrin, IgG and serum suPAR concentrations compared to healthy controls. Nephrin and IgG levels were significantly higher in patients with severe proteinuria than with mild proteinuria, and nephrin correlated strongly with biomarkers of glomerular proteinuria over time. Congruently, electron microcopy analyses showed a focal podocyte foot process effacement. suPAR correlated significantly with urinary nephrin, IgG and albumin levels, suggesting suPAR as a pathophysiological mediator in podocyte dysfunction. In contrast to INS, proteinuria recovered autonomously in hantavirus patients. This study reveals podocyte injury as main cause of proteinuria in hantavirus patients. A better understanding of the regenerative nature of hantavirus-induced glomerulopathy may generate new therapeutic approaches for INS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644703/ doi: 10.1038/s41598-020-76050-0 id: cord-326991-m0lfk0a9 author: Nuñez, Jorge H. title: Rethinking Trauma Hospital Services in one of Spain's Largest University Hospitals during the COVID-19 pandemic. How can we organize and help? Our experience. date: 2020-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The severe disruptions caused by the SARS-CoV-2 coronavirus have necessitated a redistribution of resources to meet hospitals’ current service needs during this pandemic. The aim is to share our experiences and outcomes during the first month of the Covid-19 pandemic, based on the strategies recommended and strategies we have implemented. METHODS: Our experience comes from our work at a referral hospital within the Spanish National Health System. Changes to clinical practice have largely been guided by the current evidence and four main principles: (1) patient and health-care worker protection, (2) uninterrupted necessary care, (3) conservation of health-care resources, (4) uninterrupted formation for residents. Based on these principles, changes in the service organization, elective clinical visits, emergency visits, surgical procedures, and inpatient and outpatient care were made. RESULTS: Using the guidance of experts, we were able to help the hospital address the demands of the Covid-19 outbreak. We reduced to a third of our orthopaedics and trauma hospital beds, provided coverage for general emergency services, and five ICUs, all continuing to provide care for our patients, in the form of 102 trauma surgeries, 6413 phone interviews and 520 emergency clinic visits. Also in the third week, we were able to restart morning meetings via telematics, and teaching sessions for our residents. On the other hand, eight of the healthcare personnel on our service (10.8%) became infected with Covid-19. CONCLUSIONS: As priorities and resources increasingly shift towards the COVID-19 pandemic, it is possible to maintain the high standard and quality of care necessary for trauma and orthopaedics patients while the pandemic persists. We must be prepared to organize our healthcare workers in such a way that the needs of both inpatients and outpatients are met. It is still possible to operate on those patients who need it. Unfortunately, some healthcare workers will become infected. It is essential that we protect those most susceptible to severer consequences of Covid-19. Also crucial are optimized protective measures. url: https://doi.org/10.1016/j.injury.2020.09.055 doi: 10.1016/j.injury.2020.09.055 id: cord-270525-nmebqrb1 author: Núñez-Velasco, Santiago title: Response to SARS-CoV-2 Pandemic in a Non-COVID-19 Designated Latin-American Neurosurgery Department date: 2020-05-11 words: 2660.0 sentences: 133.0 pages: flesch: 53.0 cache: ./cache/cord-270525-nmebqrb1.txt txt: ./txt/cord-270525-nmebqrb1.txt summary: METHODS An organized response regarding personnel, surgical case selection, operating room behavior, and facility reorganization were designed to prevent an internal coronavirus outbreak in the neurosurgery department at the Fray Antonio Alcalde Civil Hospital of Guadalajara. Based on the epidemiological and biological information available in the literature on COVID-19, specific measures adapted to our resources were implemented to design a protocol of organized administration of human resources both assistant and administrative, optimized surgical procedures, proper handling of personal protective equipment and adaptation of the facilities of the neurosurgery department of the FAAHC when treating neurosurgical patients with no SARS-CoV-2 known condition. This would lead us to a catastrophic scenario because there are reports of a 12% of hospital-associated transmission of the virus as the mechanism of infection of patients, that in our case are weak and many of them immunosuppressed; thus, cases of contamination of health-care personnel have also been reported, especially in non-designated COVID areas in which precautions might relax. abstract: BACKGROUND Mexico declared the first case of novel coronavirus disease (COVID-19) in February 2020. At the time we write this article, our country is facing a community spread phase, expecting a rapid increase in the number of cases and fatalities. The Fray Antonio Alcalde Civil Hospital of Guadalajara has been declared a non-COVID-19 hospital with the mission of providing care to patients already registered and also those transferred from neurosurgical departments of neighboring centers, which have been converted into COVID-19 only hospitals. METHODS An organized response regarding personnel, surgical case selection, operating room behavior, and facility reorganization were designed to prevent an internal coronavirus outbreak in the neurosurgery department at the Fray Antonio Alcalde Civil Hospital of Guadalajara. RESULTS Distancing actions by the staff and residents, including ward case discussions, neurosurgery rounds, and classes, will be carried out virtually. We classified neurosurgical patients into 4 groups depending on whether their condition demands care in 0-6 hours, 6-48 hours, 48 hours to 14 days, and >14 days. Subsequently, a questionnaire with epidemiologic, radiologic, clinical, and serologic criteria will be applied to determine the risk of COVID-19 infection to define to which area they are going to be transferred according to the different risk zones in our facility. CONCLUSIONS Despite not being a COVID-19 center, we consider all patients at the neurosurgical ward and staff members as asymptomatic carriers or infected in the preclinical period. Specific measures must be taken to ensure the safety and care of neurosurgical patients and medical staff during the community spread phase. url: https://www.sciencedirect.com/science/article/pii/S1878875020309797?v=s5 doi: 10.1016/j.wneu.2020.05.019 id: cord-338023-gb5jgqcg author: Obara, Shinju title: Anesthesiologist behavior and anesthesia machine use in the operating room during the COVID-19 pandemic: awareness and changes to cope with the risk of infection transmission date: 2020-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease [coronavirus disease 2019 (COVID-19) infection] first appeared in December 2019 in China and is now spreading worldwide. Because SARS-CoV-2 can be transmitted via aerosols and surface contaminations of the environment, appropriate use of anesthesia machines and appropriate behavior in the operation room (OR) are required specifically in relation to this disease. The use of high-performance hydrophobic filters with a high rate of virus rejection is recommended as the type of viral filter, and surgical team behaviors that result in aerosol splashes should be avoided. Appropriate hand hygiene by the anesthesiologist is crucial to prevent unexpected environmental contamination. When the anesthesia machine is used instead of an intensive care unit ventilator, it is important to keep the fresh gas flow at least equal to the minute ventilation to prevent excessive humidity in the circuit and to monitor condensation in the circuit and inspiratory carbon dioxide pressure. In addition, both the surgical smoke inherent in thermal tissue destruction and the surgical team’s shoe soles may be factors for the presence of SARS-CoV-2 in the operating room. Ensuring social distancing—even with a mask in the OR—may be beneficial because healthcare providers may be asymptomatic carriers. After the acute crisis period of COVID-19, the number of cases of essential but nonurgent surgeries for waiting patients is likely to increase; therefore, optimization of OR scheduling will be an important topic. Anesthesiologists will benefit from new standard practices focusing on the prevention of COVID-19 infection. url: https://www.ncbi.nlm.nih.gov/pubmed/32856167/ doi: 10.1007/s00540-020-02846-z id: cord-259585-mjtxiu0t author: Occhipinti, Vincenzo title: Challenges in the Care of IBD Patients During the CoViD-19 Pandemic: Report From a “Red Zone” Area in Northern Italy date: 2020-04-21 words: 2803.0 sentences: 122.0 pages: flesch: 46.0 cache: ./cache/cord-259585-mjtxiu0t.txt txt: ./txt/cord-259585-mjtxiu0t.txt summary: Every possible effort was made to quickly increase the capacity of intensive care units (ICUs) to accommodate the alarming numbers of very sick CoViD-19 patients, including constructing new units in unused areas of the hospital or converting surgical rooms into ICUs. These drastic measures were implemented in a very short period of time, and although necessary to counteract the devastation brought about by the outbreak, they also posed tremendous challenges to the care of patients with GI conditions, including those with inflammatory bowel diseases (IBD). However, for patients on biologic therapies, we have implemented a mandatory phone call-in the day before any planned hospital visit to screen for possible CoViD-19 symptoms or contact with infected individuals and to reassure patients that all possible precautions are being taken by the IBD center to reduce the risk of infection. abstract: nan url: https://doi.org/10.1093/ibd/izaa084 doi: 10.1093/ibd/izaa084 id: cord-346607-1mewok8l author: Oesterle, Tyler S. title: Substance Use Disorders and Telehealth in the COVID-19 Pandemic Era: A New Outlook date: 2020-10-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: During the current COVID-19 epidemic many outpatient chemical dependency treatment programs and clinics are decreasing the number of in-person patients contact. This has widened an already large gap between patients with substance use disorders (SUD) that need treatment and those that actually received treatment. For a disorder where group therapy is the mainstay treatment option for decades, social distancing, shelter in place and treatment discontinuation have created an urgent need for alternative approaches to addiction treatment. In an attempt to continue some care for patients in need, many a medical interventions have transitioned to a virtual environment in order to promote safe social distancing. Although there is ample evidence to support tele-medical interventions, these can be difficult to implement especially in SUD populations. This article reviews current literature for the use of tele/virtual interventions in the treatment of SUDs and offers recommendations on safe an effective implementation strategies based on the current literature. url: https://api.elsevier.com/content/article/pii/S0025619620311952 doi: 10.1016/j.mayocp.2020.10.011 id: cord-337338-7uj2r0gy author: Ohlstein, Jason F. title: Telemedicine in Otolaryngology in the COVID‐19 Era: Initial Lessons Learned date: 2020-08-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The COVID‐19 pandemic has led to unprecedented global changes in the delivery of healthcare over a short period of time. With the implementation of “shelter in place” orders, otolaryngology clinic visits at our institution were transitioned to Telemedicine. This change enabled the rapid characterization of the patients who accepted and declined Telemedicine. METHODS: Review of 525 otolaryngology patients at a tertiary care referral center with scheduled visits requiring rescheduling to a future date or a Telemedicine visit. Visit, demographic information, and reason for deferring Telemedicine were collected for analysis. RESULTS: 72% of patients declined a Telemedicine visit with the most common reason being the lack of a physical exam (97%). There was an even distribution of demographics between those who accepted and declined visits. There was an association between declining Telemedicine with older age (P = 0.0004) and otology visits (P = 0.0003), while facial plastics patients were more likely to accept (P < 0.0001). Patients scheduled earlier during the pandemic were more likely to accept a visit with a median of 28 days from onset of “shelter in place” orders vs 35 for those who declined (P < 0.0001). CONCLUSIONS: We describe our initial experience with a transition to Telemedicine, where the majority of patients would decline a virtual visit due to the lack of a physical exam. While the future remains uncertain, Telemedicine will continue to play a vital role in healthcare delivery; we believe that understanding our patient base gives critical insights that will help guide and improve virtual care to meet patient's needs. url: https://www.ncbi.nlm.nih.gov/pubmed/32740925/ doi: 10.1002/lary.29030 id: cord-284298-tcied4l5 author: Ojeahere, Margaret Isioma title: Management of psychiatric conditions and delirium during the COVID-19 pandemic across continents: The lessons thus far date: 2020-09-19 words: 6816.0 sentences: 351.0 pages: flesch: 40.0 cache: ./cache/cord-284298-tcied4l5.txt txt: ./txt/cord-284298-tcied4l5.txt summary: In the present study, twenty one early career psychiatrists (9 females and 12 males) from thirteen countries, comprising at least one from five of the seven continents (Africa, Asia, Europe, North J o u r n a l P r e -p r o o f America and South America) were approached without coercion by the lead (MIO) and co-lead (RdF) authors via WhatsApp and emails to share insights and experiences about the challenges and good practices faced in the management of delirium and other psychiatric conditions manifesting in patients with COVID-19 and during the COVID-19 era. Finally, the mental health sector should use the lessons from this pandemic to develop protocols and guidelines for the management of psychiatric conditions in periods of infectious disease outbreaks to increase their level of preparedness globally (Table 4) . abstract: BACKGROUND: With the uncertainties of COVID-19, people infected by coronavirus present with diverse psychiatric presentations. Some centers have had to manage their patients with existing protocols, others have had to come up with innovations. We aim to report the challenges and good practices recorded in the management of psychiatric conditions and delirium coexisting with COVID-19 and during the COVID-19 era across continents. MATERIAL AND METHODS: Early Career Psychiatrists (ECPs) from across five continents were approached to provide their perspective on the management of psychiatric conditions in patients with COVID-19 and during the current pandemic. RESULTS: We collected information about the experiences from ten countries. Commonalities were similar psychiatric presentations and poor preparedness across countries. Differences were varying innovations and adjustments made in the management of psychiatric conditions coexisting with COVID-19. Good practices which can be adopted by other countries are novel approaches such as telepsychiatry, proactive consultation-liaison units and enhanced community services targeted at circumventing challenges faced yet providing mental health services. CONCLUSIONS: This publication highlights the need for global preparedness in the mental health sector during outbreaks of infectious diseases. With our results we can conclude that there is the need for concerted efforts targeted at global and locally sensitive adaptation of existing protocols and the development of new guidelines for the management of psychiatric conditions for the present pandemic and subsequent occurrences. url: https://doi.org/10.1016/j.bbih.2020.100147 doi: 10.1016/j.bbih.2020.100147 id: cord-256535-fz5p2u6p author: Oki, Sogo title: Long-Term Clinical Outcome and Prognosis After Thrombectomy in Patients With Concomitant Malignancy date: 2020-10-15 words: 3376.0 sentences: 166.0 pages: flesch: 47.0 cache: ./cache/cord-256535-fz5p2u6p.txt txt: ./txt/cord-256535-fz5p2u6p.txt summary: Among the eight patients who survived more than 2 weeks from onset, four patients showed good clinical outcome [modified Rankin Scale (mRS) <2] at 60 days posttreatment and were able to continue treatment for malignancy. The development of endovascular thrombectomy (EVT) is a recent advancement, and numerous randomized clinical trials have proved the efficacy of EVT for the treatment of acute ischemic stroke (AIS) in patients with large vessel occlusion (LVO) (6) (7) (8) (9) (10) (11) . Patient information, including age, sex, location of malignancy, cell type, cancer staging, malignancy treatment before stroke onset, concomitant stroke risk factors (hypertension, diabetes, hyperlipidemia, atrial fibrillation, pulmonary embolism or deep venous thrombosis, and previous history of stroke), premorbid antiplatelet/anticoagulant drug, and blood D-dimer level at admission (17) were obtained from the medical records. abstract: Endovascular thrombectomy (EVT) is the preferred treatment strategy for patients with acute ischemic stroke (AIS). However, clinical outcome and prognosis in patients who undergo EVT in response to AIS with concomitant malignancy have not been fully elucidated. Data of patients with malignancy who underwent EVT at participating institutions between January 2015 and April 2019 were retrospectively analyzed. Patient characteristics, treatment methods, posttreatment strategy, and long-term prognosis were evaluated in 12 patients with prediagnoses of malignancy. Good revascularization (TICI 2b or higher) was achieved in 10 of 12 patients. Among the eight patients who survived more than 2 weeks from onset, four patients showed good clinical outcome [modified Rankin Scale (mRS) <2] at 60 days posttreatment and were able to continue treatment for malignancy. However, seven of eight patients died within a year of EVT (median survival, 83 days) due to progression of malignancy. One-year survival was achieved in only one patient whose etiology of stroke was determined as infectious endocarditis and not Trousseau syndrome. Even after successful revascularization and good short-term clinical outcome, the long-term prognosis after thrombectomy in patients with malignancy was poor. Thrombectomy for concomitant malignancy requires judicious decision, and further studies are necessary to fully elucidate its efficacy. url: https://www.ncbi.nlm.nih.gov/pubmed/33178112/ doi: 10.3389/fneur.2020.572589 id: cord-353340-l0icku0i author: Olaoye, Omotayo title: Improving Access to Antimicrobial Prescribing Guidelines in 4 African Countries: Development and Pilot Implementation of an App and Cross-Sectional Assessment of Attitudes and Behaviour Survey of Healthcare Workers and Patients date: 2020-08-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Smartphone apps have proven to be an effective and acceptable resource for accessing information on antimicrobial prescribing. The purpose of the study is to highlight the development and implementation of a smartphone/mobile app (app) for antimicrobial prescribing guidelines (the Commonwealth Partnerships for Antimicrobial Stewardship—CwPAMS App) in Ghana, Tanzania, Uganda and Zambia and to evaluate patients’ and healthcare providers’ perspectives on the use of the App in one of the participating institutions. Two structured cross-sectional questionnaires containing Likert scale, multiple-choice, and open-ended questions were issued to patients and healthcare workers six months after the introduction of the app at one of the hospital sites. Metrics of the use of the app for a one-year period were also obtained. Download and use of the app peaked between September and November 2019 with pharmacists accounting for the profession that the most frequently accessed the app. More than half of the responding patients had a positive attitude to the use of the app by health professionals. Results also revealed that more than 80% of health care workers who had used the CwPAMS App were comfortable using a smartphone/mobile device on a ward round, considered the app very useful, and found it to improve their awareness of antimicrobial stewardship, including documentation of the indication and duration for antimicrobials on the drug chart. It also encouraged pharmacists and nurses to challenge inappropriate antimicrobial prescribing. Overall, our findings suggest that its use as a guide to antimicrobial prescribing sparked positive responses from patients and health professionals. Further studies will be useful in identifying the long-term consequences of the use of the CwPAMS App and scope to implement in other settings, in order to guide future innovations and wider use. url: https://www.ncbi.nlm.nih.gov/pubmed/32872419/ doi: 10.3390/antibiotics9090555 id: cord-261383-izd1vn6f author: Oleynick, Christopher title: Symptoms of Pleurisy as the Initial Presentation of COVID-19 date: 2020-07-24 words: 2028.0 sentences: 96.0 pages: flesch: 50.0 cache: ./cache/cord-261383-izd1vn6f.txt txt: ./txt/cord-261383-izd1vn6f.txt summary: Patient: Male, 48-year-old Final Diagnosis: Viral pleurisy Symptoms: Pleuritic chest pain Medication: — Clinical Procedure: — Specialty: General and Internal Medicine OBJECTIVE: Unusual clinical course BACKGROUND: Severe acute respiratory syndrome coronavirus 2, the virus responsible for Coronavirus Disease 2019 (COVID-19), has infected more than 8 million people worldwide and placed massive strains on healthcare systems around the world. CASE REPORT: A 48-year-old man with hypertension and type 2 diabetes mellitus presented to the Emergency Department with acute-onset pleuritic chest pain that had developed 1 day earlier and was found to be hypoxemic, requiring supplemental oxygen. CONCLUSIONS: I report a patient who experienced pleuritic chest pain from viral pleurisy that was the initial manifestation of COVID-19 which, to the best of my knowledge, has not yet been reported in the literature. I report a patient who experienced pleuritic chest pain as the initial manifestation of infection with COVID-19, who subsequently developed more typical features, including cough, fever, shortness of breath, and hypoxia. abstract: Patient: Male, 48-year-old Final Diagnosis: Viral pleurisy Symptoms: Pleuritic chest pain Medication: — Clinical Procedure: — Specialty: General and Internal Medicine OBJECTIVE: Unusual clinical course BACKGROUND: Severe acute respiratory syndrome coronavirus 2, the virus responsible for Coronavirus Disease 2019 (COVID-19), has infected more than 8 million people worldwide and placed massive strains on healthcare systems around the world. Although classically causing cough, fever, and shortness of breath, increasing evidence suggests that manifestations of COVID-19 can be more subtle or masquerade as other clinical entities. CASE REPORT: A 48-year-old man with hypertension and type 2 diabetes mellitus presented to the Emergency Department with acute-onset pleuritic chest pain that had developed 1 day earlier and was found to be hypoxemic, requiring supplemental oxygen. He was admitted under the internal medicine service and underwent an extensive work-up for his chest pain and hypoxemia, including a negative computed tomography scan with pulmonary embolism protocol, negative nuclear medicine ventilation/perfusion scan, normal electrocardiogram, and normal echocardiography. In the end, he was diagnosed with viral pleuritis as the diagnosis of exclusion. Our patient subsequently developed a fever and shortness of breath and his nasopharyngeal swab performed on admission to hospital returned positive for COVID-19. The patient’s pleuritic pain and oxygen requirements improved with supportive management over the next several days. CONCLUSIONS: I report a patient who experienced pleuritic chest pain from viral pleurisy that was the initial manifestation of COVID-19 which, to the best of my knowledge, has not yet been reported in the literature. This case report further emphasizes that COVID-19 may present with atypical symptoms. It is crucial to be aware of these atypical presentations of COVID-19 so that patients are appropriately identified, isolated, and treated, while protecting health care workers from exposure. url: https://doi.org/10.12659/ajcr.925775 doi: 10.12659/ajcr.925775 id: cord-321472-n4nnmlv1 author: Oliveira, E. title: ICU Outcomes and Survival in Patients with Severe COVID-19 in the Largest Health Care System in Central Florida date: 2020-08-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background Observational studies have consistently described poor clinical outcomes and increased ICU mortality in patients with severe coronavirus disease 2019 (COVID-19) who require mechanical ventilation (MV). Our study describes the clinical characteristics and outcomes of patients with severe COVID-19 admitted to ICU in the largest health care system in the state of Florida, United States. Methods Retrospective cohort study of patients admitted to ICU due to severe COVID-19 in AdventHealth health system in Orlando, Florida from March 11th until May 18th, 2020. Patients were characterized based on demographics, baseline comorbidities, severity of illness, medical management including experimental therapies, laboratory markers and ventilator parameters. Major clinical outcomes analyzed at the end of the study period were: hospital and ICU length of stay, MV-related mortality and overall hospital mortality of ICU patients. Results Out of total of 1283 patients with COVID-19, 131 (10.2%) met criteria for ICU admission (median age: 61 years [interquartile range {IQR}, 49.5-71.5]; 35.1% female). Common comorbidities were hypertension (84; 64.1%), and diabetes (54; 41.2%). Of the 131 ICU patients, 109 (83.2%) required MV and 9 (6.9%) received ECMO. Lower positive end expiratory pressure (PEEP) were observed in survivors [9.2 (7.7-10.4)] vs non-survivors [10 (9.1-12.9] p= 0.004]. Compared to non-survivors, survivors had a longer MV length of stay (LOS) [14 (IQR 8-22) vs 8.5 (IQR 5-10.8) p< 0.001], Hospital LOS [21 (IQR 13-31) vs 10 (7-1) p< 0.001] and ICU LOS [14 (IQR 7-24) vs 9.5 (IQR 6-11), p < 0.001]. The overall hospital mortality and MV-related mortality were 19.8% and 23.8% respectively. After exclusion of hospitalized patients, the hospital and MV-related mortality rates were 21.6% and 26.5% respectively. Conclusions Our study demonstrates an important improvement in mortality of patients with severe COVID-19 who required ICU admission and MV in comparison to previous observational reports and emphasize the importance of standard of care measures in the management of COVID-19. url: http://medrxiv.org/cgi/content/short/2020.08.25.20181909v1?rss=1 doi: 10.1101/2020.08.25.20181909 id: cord-282963-p04c5nn7 author: Oliveros, Estefania title: Rapid Deterioration of Hospital-Acquired COVID-19 in a Patient on Extracorporeal Left Ventricular Assist Support date: 2020-09-21 words: 1063.0 sentences: 74.0 pages: flesch: 46.0 cache: ./cache/cord-282963-p04c5nn7.txt txt: ./txt/cord-282963-p04c5nn7.txt summary: DESIGN: : We present a unique case report of hospital-acquired COVID-19 in a patient on temporary mechanical circulatory support. Emphasize the importance of early advanced care planning in patients with heart failure and COVID-19 3. Over the course of 2 hours the patient developed severe hypoxemia with oxygen saturations of 70%, followed by hypotension and low flows through the Centrimag®. While predictors of rapid disease progression have yet to be elucidated, early trends of inflammatory markers may be helpful to risk stratify COVID-19 patients and identify those who are likely to become critically ill (1). Presently broad testing of asymptomatic patients and HCW for COVID-19 is not available but may have impacted disease transmission in this case. It illustrates the high risk for development of COVID-19 for vulnerable hospitalized patients. It illustrates the high risk for development of COVID-19 for vulnerable hospitalized patients. Clinical Pathology of Critical Patients with Novel Coronavirus Pneumonia (COVID-19). abstract: IMPORTANCE: : As the Coronavirus disease 2019 (COVID-19) pandemic accelerates, our hospitals have become overwhelmed. OBJECTIVE: : To describe detection of COVID-19 in asymptomatic hospitalized individuals awaiting advanced therapies for HF and the management of complications of COVID-19. DESIGN: : We present a unique case report of hospital-acquired COVID-19 in a patient on temporary mechanical circulatory support. MAIN OUTCOME: : Despite intensive care and monitoring, he developed rapid progression of hypoxic respiratory failure which led to his death. CONCLUSION: : This case highlights various considerations for a patient with temporary MCS. It illustrates the high risk for development of COVID-19 for vulnerable hospitalized patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33010519/ doi: 10.1016/j.hrtlng.2020.08.021 id: cord-338346-e3fk6gz2 author: Oliveros, Estefania title: Coronavirus Disease 2019 and Heart Failure: A Multiparametric Approach date: 2020-08-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19) is a debilitating viral infection and, to date, 628,903 people have died from it, numbers that cannot yet be compared to the 50 million who died in the 1918 flu pandemic. As COVID-19 became better understood, cardiovascular manifestations associated with it were identified. This led to a complete healthcare restructuring with virtual clinics and changes to the triaging of critically ill patients. There are a lot of questions over how COVID-19 affects patients with heart failure (HF) as this condition is a leading cause of cardiovascular death. This review describes the cardiovascular implications of COVID-19 and new practices surrounding the use of telehealth to follow up and triage patients with HF. Current practices supported by medical societies, the role of angiotensin-converting enzyme inhibitors and, finally, a brief note regarding the management of advanced HF patients will also be discussed. url: https://doi.org/10.15420/cfr.2020.09 doi: 10.15420/cfr.2020.09 id: cord-323273-q53wf6au author: Olivia Li, Ji-Peng title: Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective date: 2020-09-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The simultaneous maturation of multiple digital and telecommunications technologies in 2020 has created an unprecedented opportunity for ophthalmology to adapt to new models of care using tele-health supported by digital innovations. These digital innovations include artificial intelligence (AI), 5th generation (5G) telecommunication networks and the Internet of Things (IoT), creating an inter-dependent ecosystem offering opportunities to develop new models of eye care addressing the challenges of COVID-19 and beyond. Ophthalmology has thrived in some of these areas partly due to its many image-based investigations. Tele-health and AI provide synchronous solutions to challenges facing ophthalmologists and healthcare providers worldwide. This article reviews how countries across the world have utilised these digital innovations to tackle diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, glaucoma, refractive error correction, cataract and other anterior segment disorders. The review summarises the digital strategies that countries are developing and discusses technologies that may increasingly enter the clinical workflow and processes of ophthalmologists. Furthermore as countries around the world have initiated a series of escalating containment and mitigation measures during the COVID-19 pandemic, the delivery of eye care services globally has been significantly impacted. As ophthalmic services adapt and form a “new normal”, the rapid adoption of some of telehealth and digital innovation during the pandemic is also discussed. Finally, challenges for validation and clinical implementation are considered, as well as recommendations on future directions. url: https://www.ncbi.nlm.nih.gov/pubmed/32898686/ doi: 10.1016/j.preteyeres.2020.100900 id: cord-317028-f3bpwm5j author: Olmsted, Russell N. title: Prevention by Design: Construction and Renovation of Health Care Facilities for Patient Safety and Infection Prevention date: 2016-08-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The built environment supports the safe care of patients in health care facilities. Infection preventionists and health care epidemiologists have expertise in prevention and control of health care–associated infections (HAIs) and assist with designing and constructing facilities to prevent HAIs. However, design elements are often missing from initial concepts. In addition, there is a large body of evidence that implicates construction and renovation as being associated with clusters of HAIs, many of which are life threatening for select patient populations. This article summarizes known risks and prevention strategies within a framework for patient safety. url: https://www.ncbi.nlm.nih.gov/pubmed/27515144/ doi: 10.1016/j.idc.2016.04.005 id: cord-328039-xt17gvcp author: Olson, Michael C. title: RadioGraphics Update: Venous Thrombosis and Hypercoagulability in the Abdomen and Pelvis—Findings in COVID-19 date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Editor’s Note.—Articles in the RadioGraphics Update section provide current knowledge to supplement or update information found in full-length articles previously published in RadioGraphics. Authors of the previously published article provide a brief synopsis that emphasizes important new information such as technological advances, revised imaging protocols, new clinical guidelines involving imaging, or updated classification schemes. Articles in this section are published solely online and are linked to the original article. url: https://doi.org/10.1148/rg.2020200119 doi: 10.1148/rg.2020200119 id: cord-356127-xy5tyd7t author: Omidi, Negar title: Prosthetic heart valves and the COVID‐19 pandemic era: What should we be concerned about? date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The disturbance in the international normalized ratio (INR) in patients receiving warfarin therapy is of concern. We aimed to evaluate coagulation features in hospitalized patients under warfarin treatment for prosthetic heart valves during the novel coronavirus disease 2019 (COVID‐19) pneumonia pandemic. METHODS: Between 20 February and 28 March 2020, 10 patients (7 males) who were under warfarin therapy for prosthetic heart valves were hospitalized after a diagnosis of COVID‐19 in Tehran Heart Center, Tehran, Iran. The clinical, paraclinical, and in‐hospital outcomes were described. The patients were followed for 4 weeks. RESULTS: The median age was 62 years. All the patients received antiviral treatment, either lopinavir/ritonavir or oseltamivir. The serum level of high‐sensitivity C‐reactive protein ranged between 0.24 and 15.24 mg/dL. Alanine aminotransaminase was normal in all the patients except for two, with levels 1.6 and 4.2 times above normal values. The INR increased in all the patients. One (10%) patient died in the hospital. No bleeding, ischemic, or thrombotic events occurred during the hospital stay and within the 4‐week follow‐up. CONCLUSIONS: Antiviral therapy in patients with COVID‐19 with prosthetic heart valves might be an issue responsible for an uncontrolled INR. Liver injury may happen in a minority of patients. Bridging in these patients during the antiviral treatment might be required and because of significant INR fluctuations, it might be safer to prescribe antiviral treatment in an inpatient setting. url: https://doi.org/10.1111/jocs.14707 doi: 10.1111/jocs.14707 id: cord-279513-m4jdc8ua author: Onesti, Concetta Elisa title: Oncological care organisation during COVID-19 outbreak date: 2020-08-26 words: 4145.0 sentences: 204.0 pages: flesch: 49.0 cache: ./cache/cord-279513-m4jdc8ua.txt txt: ./txt/cord-279513-m4jdc8ua.txt summary: A triage for patients with cancer before hospital or clinic visits was conducted by 90.5% of centres before consultations, 95.2% before day care admissions and in 100% of the cases before overnight hospitalisation by means of phone calls, interactive online platforms, swab test and/or chest CT scan. The topics investigated in the survey included preventive measures taken before and after admission to the hospital, instructions given to patients and professionals, general measures for risk reduction of virus spread, specific measures in the hospitalisation unit, general organisation of the centre, organisation of multidisciplinary meetings and activities of other healthcare professionals, staff management and antibody testing. Patients were subjected to a triage for signs of infection prior to presenting to the oncology units in the majority of the centres, notably in 19/21 institutions (90.5%) before consultations, in 20/21 (95.2%) before day care outpatient infusion room admissions and in 20/20 (100%) before overnight hospitalisation (figure 2). abstract: BACKGROUND: COVID-19 appeared in late 2019, causing a pandemic spread. This led to a reorganisation of oncology care in order to reduce the risk of spreading infection between patients and healthcare staff. Here we analysed measures taken in major oncological units in Europe and the USA. METHODS: A 46-item survey was sent by email to representatives of 30 oncological centres in 12 of the most affected countries. The survey inquired about preventive measures established to reduce virus spread, patient education and processes employed for risk reduction in each oncological unit. RESULTS: Investigators from 21 centres in 10 countries answered the survey between 10 April and 6 May 2020. A triage for patients with cancer before hospital or clinic visits was conducted by 90.5% of centres before consultations, 95.2% before day care admissions and in 100% of the cases before overnight hospitalisation by means of phone calls, interactive online platforms, swab test and/or chest CT scan. Permission for caregivers to attend clinic visits was limited in many centres, with some exceptions (ie, for non-autonomous patients, in the case of a new diagnosis, when bad news was expected and for terminally ill patients). With a variable delay period, the use of personal protective equipment was unanimously mandatory, and in many centres, only targeted clinical and instrumental examinations were performed. Telemedicine was implemented in 76.2% of the centres. Separated pathways for COVID-19-positive and COVID-19-negative patients were organised, with separate inpatient units and day care areas. Self-isolation was required for COVID-19-positive or symptomatic staff, while return to work policies required a negative swab test in 76.2% of the centres. CONCLUSION: Many pragmatic measures have been quickly implemented to deal with the health emergency linked to COVID-19, although the relative efficacy of each intervention should be further analysed in large observational studies. url: https://doi.org/10.1136/esmoopen-2020-000853 doi: 10.1136/esmoopen-2020-000853 id: cord-011093-d9dbvbcy author: Orange, Jordan S. title: How I Manage Natural Killer Cell Deficiency date: 2019-11-22 words: 8253.0 sentences: 339.0 pages: flesch: 45.0 cache: ./cache/cord-011093-d9dbvbcy.txt txt: ./txt/cord-011093-d9dbvbcy.txt summary: Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient''s clinical immunodeficiency. In order to be as clear as possible: NKD is a subset of PID in which the NK cell abnormality represents the major immunological defect resulting in the clinical immunodeficiency. As delineated above an example of this broader subset of PIDs that include an impact upon NK cells is NK -SCID, where the lack of NK cells is potentially relevant but not the major immunological defect causing clinical immunodeficiency. That said, to be an NKD, again the NK cell abnormality must represent the primary immunological defect presumably leading to the patient''s clinical immunodeficiency. A patient with a known PID who also has abnormal NK cell numbers or functional tests should similarly not be labeled as having an NKD. abstract: Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient’s clinical immunodeficiency. This is distinct from a much larger group of PIDs that include an NK cell abnormality as a minor component of the immunodeficiency. Patients with NKD most frequently have atypical consequences of herpesviral infections. There are now 6 genes that have been ascribed to causing NKD, some exclusively and others that also cause other known immunodeficiencies. This list has grown in recent years and as such the mechanistic and molecular clarity around what defines an NKD is an emerging and important field of research. Continued increased clarity will allow for more rational approaches to the patients themselves from a therapeutic standpoint. Having evaluated numerous individuals for NKD, I share my perspective on approaching the diagnosis and managing these patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223544/ doi: 10.1007/s10875-019-00711-7 id: cord-286683-mettlmhz author: Ortiz-Prado, Esteban title: Clinical, molecular and epidemiological characterization of the SARS-CoV2 virus and the Coronavirus disease 2019 (COVID-19), a comprehensive literature review date: 2020-05-30 words: 13299.0 sentences: 726.0 pages: flesch: 45.0 cache: ./cache/cord-286683-mettlmhz.txt txt: ./txt/cord-286683-mettlmhz.txt summary: Interestingly, the increased amounts of proinflammatory cytokines in serum associated with pulmonary inflammation and extensive lung damage described both in SARS [59] and MERS diseases [60] were also reported in the early study of 41 patients with COVID-19 in Wuhan [41] . A recently published case report of a patient with mild-to-moderate COVID-19 revealed the presence of an increased activated CD4+ T cells and CD8+ T cells, antibody-secreting cells (ASCs), follicular helper T cells (TFH cells), and anti-SARS-CoV-2 IgM and IgG antibodies, suggesting that both cellular and humoral responses are important in containing the virus and inhibiting severe pathology [82] . Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series abstract: Abstract Coronaviruses are an extensive family of viruses that can cause disease in both animals and humans. The current classification of coronaviruses recognizes 39 species in 27 subgenera that belong to the family Coronaviridae. From those, at least seven coronaviruses are known to cause respiratory infections in humans. Four of these viruses can cause common cold-like symptoms. Those that infect animals can evolve and become infectious to humans. Three recent examples of these viral jumps include SARS CoV, MERS-CoV and SARS CoV-2 virus. They are responsible for causing severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and the most recently discovered coronavirus disease during 2019 (COVID-19). COVID-19, a respiratory disease caused by the SARS-CoV-2 virus, was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. The rapid spread of the disease has taken the scientific and medical community by surprise. Latest figures from 20th May 2020 show more than 5 million people had been infected with the virus, causing more than 330,000 deaths in over 210 countries worldwide. The large amount of information received daily relating to COVID-19 is so abundant and dynamic that medical staff, health authorities, academics and the media are not able to keep up with this new pandemic. In order to offer a clear insight of the extensive literature available, we have conducted a comprehensive literature review of the SARS CoV-2 Virus and the Coronavirus Diseases 2019 (COVID-19). url: https://doi.org/10.1016/j.diagmicrobio.2020.115094 doi: 10.1016/j.diagmicrobio.2020.115094 id: cord-312918-iof45k1r author: Ortolani, Claudio title: Hydroxychloroquine and dexamethasone in COVID-19: who won and who lost? date: 2020-09-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: On June 30, 2020, the WHO reported over 10 millions of COVID-19 cases worldwide with over half a million deaths. In severe cases the disease progresses into an Acute Respiratory Distress Syndrome (ARDS), which in turn depends on an overproduction of cytokines (IL-6, TNFα, IL-12, IL-8, CCL-2 and IL1) that causes alveolar and vascular lung damage. Clearly, it is essential to find an immunological treatment that controls the “cytokine storm”. In the meantime, however, it is essential to have effective antiviral and anti-inflammatory drugs available immediately. PHARMACOLOGIC THERAPY FOR COVID-19: Hydroxychloroquine or chloroquine have been widely adopted worldwide for the treatment of SARS-CoV-2 pneumonia. However, the choice of this treatment was based on low quality of evidence, i.e. retrospective, non-randomized controlled studies. Recently, four large Randomized Controlled Trials (RCTs) have been performed in record time delivering reliable data: (1) the National Institutes of Health (NIH) RCT included 60 hospitals participating all over the world and showed the efficacy of remdesivir in reducing the recovery time in hospitalized adults with COVID-19 pneumonia; (2) three large RCTs already completed, for hydroxychloroquine, dexamethasone and Lopinavir and Ritonavir respectively. These trials were done under the umbrella of the 'Recovery' project, headed by the University of Oxford. The project includes 176 participating hospitals in the UK and was set up to verify the efficacy of some of the treatments used for COVID-19. These three ‘Recovery’ RCTs concluded definitely: (a) that treatment with hydroxychloroquine provides no benefits in patients hospitalized with COVID-19; (b) that treatment with dexamethasone reduced deaths by one-third in COVID-19 patients that were mechanically ventilated, and by one-fifth in patients receiving oxygen only; (c) that the combination of Lopinavir and Ritonavir is not effective in reducing mortality in COVID-19 hospitalized patients. CONCLUSIONS: The results of these four large RCTs have provided sound indications to doctors for the treatment of patients with COVID-19 and prompted the correction of many institutional provisions and guidelines on COVID-19 treatments (i.e. FDA, NIH, UK Health Service, etc.). Even though a definitive treatment for COVID-19 has not yet been found, large RCTs stand as the Gold Standards for COVID-19 therapy and offer a solid scientific base on which to base treatment decisions. url: https://doi.org/10.1186/s12948-020-00132-7 doi: 10.1186/s12948-020-00132-7 id: cord-034157-uif9xtvl author: Ortoleva, Jamel title: Anesthetic Considerations for Recovered COVID-19 Patients date: 2020-10-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581371/ doi: 10.1053/j.jvca.2020.10.032 id: cord-022119-bzd9e1q6 author: Orzell, Susannah title: Pharyngitis and Pharyngeal Space Infections: fever, sore throat, difficulty swallowing date: 2018-10-15 words: 7308.0 sentences: 416.0 pages: flesch: 44.0 cache: ./cache/cord-022119-bzd9e1q6.txt txt: ./txt/cord-022119-bzd9e1q6.txt summary: Deep neck space infections can also extend directly into the mediastinum or the lungs causing life-threatening mediastinitis or pneumonia, underscoring the importance of early recognition and treatment. The initial approach to a patient with suspected pharyngitis or parapharyngeal space infection, however, should always include a careful assessment for signs of airway compromise. Patients with persistent symptoms, who do not respond to empiric therapy based on the suspected diagnosis of infection, should undergo additional diagnostic testing to evaluate for the presence of the more unusual infectious and noninfectious entities. Deep neck space infections can present as discrete organized abscesses within specific neck spaces, as a soft tissue phlegmons without clearly forming collections of pus, or rarely, as a very rapidly destructive life-threatening process called necrotizing fasciitis. Complications of bacterial pharyngitis and deep neck space infections are uncommon, particularly if appropriate antibiotic therapy has been instituted and immediate surgical concerns have been addressed; however direct extension and invasion into surrounding structures or spaces are always a risk. abstract: Pharyngeal infections are very common in patients of all ages. They are typically associated with a sore and swollen throat that makes it difficult for the patient to swallow. They may also be accompanied by fevers, swollen lymph nodes, cough, voice hoarseness, and classic symptoms of an upper respiratory infection such as rhinorrhea. The majority of these infections are benign and run a self-limited course, although they often cause patients significant discomfort. A small but still significant number of cases will be due to a more serious process, such as a deep neck space infection. It is important to recognize the clinical and radiographic differences between these patients and patients with simple pharyngitis and triage them appropriately. Failure to recognize and treat patients with more serious infections can have dire consequences and can lead to increased morbidity and mortality. It is also important to recognize that certain populations of patients will be more susceptible to atypical infections. Specific conditions, particularly those that lead to immunocompromise, should prompt the clinician to expand their differential and consider atypical causes of pharyngeal infections. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153042/ doi: 10.1007/978-3-319-91080-2_5 id: cord-355484-2igc5wzx author: Oteo, J. A. title: A short therapeutic regimen based on hydroxychloroquine plus azithromycin for the treatment of COVID-19 in patients with non-severe disease. A strategy associated with a reduction in hospital admissions and complications. date: 2020-06-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The new SARS-CoV-2 infection named COVID-19 has severely hit our Health System. At the time of writing this paper no medical therapy is officially recommended or has shown results in improving the outcomes in COVID-19 patients. With the aim of diminishing the impact in Hospital admissions and reducing the number of medical complications, we implemented a strategy based on a Hospital Home-Care Unit (HHCU) using an easy-to-use treatment based on an oral administration regimen outside the hospital with hydroxychloroquine (HCQ) plus azithromycin (AZM) for a short period of 5 days. Patients and methods: Patients [≥] 18 years old visiting the emergency room at the Hospital Universitario San Pedro de Logrono (La Rioja) between March, 31st and April, 12th diagnosed with COVID-19 with confirmed SARS-CoV-2 infection by a specific PCR, as follows: Patients with pneumonia (CURB [≤] 1) who did not present severe comorbidities and had no processes that contraindicated this therapeutic regime. Olygosimptomatic patients without pneumonia aged [≥] 55 years. Patients [≥] 18 years old without pneumonia with significant comorbidities. We excluded patients with known allergies to some of the antimicrobials used and patients treated with other drugs that increase the QTc or with QTc >450msc. The therapeutic regime was: HCQ 400 mg every twice in a loading dose followed by 200 mg twice for 5 days, plus AZM 500 mg on the first day followed by 250 mg daily for 5 days. A daily telephone follow-up was carried out from the hospital by the same physician. The end-points of our study were: 1.- To measure the need for hospital admission within 15 days after the start of treatment. 2.- To measure the need to be admitted to the intensive care unit (ICU) within 15 days after the start of the treatment. 3.- To describe the severity of the clinical complications developed. 4.- To measure the mortality within 30 days after starting treatment (differentiating if the cause is COVID-19 or something else). 5.-To describe the safety and adverse effects of the therapeutic regime. Results: During the 13 days studied a total of 502 patients were attended in the emergency room due to COVID-19. Forty-two were sent at home; 80 were attended by the HHCU (patients on this study) and 380 were admitted to the Hospital. In our series there were a group of 69 (85.18%) patients diagnosed with pneumonia (37 males and 32 females). Most of them, 57 (82.60%) had a CURB65 score of <1 (average age 49) and 12 (17.40%) a CURB score of 1 (average age 63). Eighteen (22.50%) of the pneumonia patients also had some morbidity as a risk factor. 11 patients (13.75%) without pneumonia were admitted to the HHCU because comorbidities or age [≥] 55 years. Six patients with pneumonia had to be hospitalized during the observation period, 3 of them because side effects and 3 because of worsening. One of these patients, with morbid obesity and asthma, had clinical worsening needing mechanical ventilation at ICU and developed acute distress respiratory syndrome. With the exception of the patient admitted to the ICU, the rest of the patients were discharged at home in the following 8 days (3 to 8 days). Twelve patients (15%), 11 of whom had pneumonia, experienced side effects affecting mainly the digestive. In another patient a QTc interval prolongation (452 msc) was observed. In total 3 of these patients had to be admitted in the Hospital, 2 because of vomiting and 1 because a QTc interval lengthening. None of the patients needed to stop the HCQ or AZM and all the 80 patients finished the therapeutic strategy. From the group without pneumonia only a patient developed diarrhea that did not require hospitalization or stop the medication. Conclusions: Our strategy has been associated with a reduction in the burden of hospital pressure, and it seems to be successful in terms of the number of patients who have developed serious complications and / or death. None of the patients died in the studied period and only 6 have to be admitted in conventional hospitalization area. url: http://medrxiv.org/cgi/content/short/2020.06.10.20101105v1?rss=1 doi: 10.1101/2020.06.10.20101105 id: cord-348535-tvs1snq8 author: Ottaviani, Silvia title: What is the best drug to treat COVID-19? The need for randomized controlled trials date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the biggest public health challenge to the biomedical community of the last century. Despite multiple public health measures,1, 2, 3 there remains an urgent need for pharmacologic therapies to treat infected patients, minimize mortality, and decrease pressures on intensive care units and health systems and optimally, they should also decrease subsequent transmission. url: https://api.elsevier.com/content/article/pii/S2666634020300027 doi: 10.1016/j.medj.2020.04.002 id: cord-021075-8hba6au3 author: Ouallet, J.-C. title: Aspects cliniques, physiopathologiques, et thérapeutiques de la sclérose en plaques date: 2004-07-29 words: 25142.0 sentences: 2490.0 pages: flesch: 70.0 cache: ./cache/cord-021075-8hba6au3.txt txt: ./txt/cord-021075-8hba6au3.txt summary: Les patients n''ayant eu qu''une poussée ne peuvent pas être classés dans une des quatre formes, alors qu''une majorité d''entre eux présente déjà probablement une SEP et que la répétition des IRM permet d''établir le diagnostic précocement en montrant l''apparition de nouvelles lésions (voir plus loin les critères diagnostiques). Ces critères stipulent que chez des patients ayant eu un premier épisode démyélinisant et réunissant les critères de Barkhof, l''apparition d''une lésion rehaussée par le gadolinium dans un territoire ne correspondant pas à la poussée initiale, sur une IRM réalisée au moins 3 mois après le début des troubles, est suffisante. De même, une méta-analyse des études longitudinales des formes rémittentes et secondairement progressives ayant utilisé le Gd a montré que le nombre de lésions Gd+ mesuré chaque mois pendant 6 mois était modestement prédictif du taux de poussées de l''année suivante mais pas de l''évolution du handicap dans les 12 à 24 mois suivants. abstract: Multiple sclerosis (MS) is characterized by multiple demyelinating lesions disseminated in the central nervous system. The clinical course of MS involves acute attacks leading to permanent disability and a chronic progressive stage occurring at the beginning of the disease or after a relapsing-remitting phase. Investigations that provide supportive evidence for the diagnosis of MS are magnetic resonance imaging and cerebrospinal fluid examination. Recent pathological studies showed evidence of early axonal pathology, remyelination in some cases, and diffuse pathology. Genetic and immunological studies suggest that MS is an auto-immune disease, partially genetically determined but the role of an environmental factor, possibly infectious is possible. Cumulative evidence of the efficacy of interferon beta and other disease-modifying drug therapy has completely modified the therapeutic approach of MS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148977/ doi: 10.1016/j.emcn.2004.05.002 id: cord-302382-eifh95zm author: Owji, Hajar title: Immunotherapeutic approaches to curtail COVID-19 date: 2020-08-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19, the disease induced by the recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has imposed an unpredictable burden on the world. Drug repurposing has been employed to rapidly find a cure; but despite great efforts, no drug or vaccine is presently available for treating or prevention of COVID-19. Apart from antivirals, immunotherapeutic strategies are suggested considering the role of the immune response as the host defense again the virus, and the fact that SARS-CoV-2 suppresses interferon induction as an immune evasion strategy. Active immunization through vaccines, interferon administration, passive immunotherapy by convalescent plasma or synthesized monoclonal and polyclonal antibodies, as well as immunomodulatory drugs, are different immunotherapeutic approaches that will be mentioned in this review. The focus would be on passive immunotherapeutic interventions. Interferons might be helpful in some stages. Vaccine development has been followed with unprecedented speed. Some of these vaccines have been advanced to human clinical trials. Convalescent plasma therapy is already practiced in many countries to help save the lives of severely ill patients. Different antibodies that target various steps of SARS-CoV-2 pathogenesis or the associated immune responses are also proposed. For treating the cytokine storm induced at a late stage of the disease in some patients, immune modulation through JAK inhibitors, corticosteroids, and some other cognate classes are evaluated. Given the changing pattern of cytokine induction and immune responses throughout the COVID-19 disease course, different adapted approaches are needed to help patients. Gaining more knowledge about the detailed pathogenesis of SARS-CoV-2, its interplay with the immune system, and viral-mediated responses are crucial to identify efficient preventive and therapeutic approaches. A systemic approach seems essential in this regard. url: https://www.sciencedirect.com/science/article/pii/S1567576920324309?v=s5 doi: 10.1016/j.intimp.2020.106924 id: cord-281064-b69p44uq author: Ozder, Aclan title: A Novel Indicator Predicts 2019 Novel Coronavirus Infection in Subjects with Diabetes date: 2020-07-03 words: 3499.0 sentences: 195.0 pages: flesch: 51.0 cache: ./cache/cord-281064-b69p44uq.txt txt: ./txt/cord-281064-b69p44uq.txt summary: Analysis of 11 studies regarding laboratory abnormalities in patients with COVID-19 did not mention raised blood glucose or diabetes as predictor of severe disease [12] . Previous results of complete blood count of the enrolled same non-diabetic individuals with Covid infection which were studied during their last visit to any out-patient clinic at the hospital before onset of Covid infection were yielded from the archive records via patient information management system of the hospital. The MPV values of age-and sex-matched 160 laboratory confirmed Covid patients without diabetes admitted to the Covid out-patient clinic were detected as 10.49 ± 0.96 and 10.66 ± 0.94 before and after Covid infection in these individuals, respectively (p=0.37). We thought that the statistically significant difference in MPV between diabetic patients before onset of Covid infection and healthy individuals was caused by hyperglycemia in diabetes. abstract: Abstract Aims Diabetes mellitus (DM) is associated with significant morbidity and mortality. The disease severity in 2019 novel coronavirus (Covid 19) infection has varied from mild self-limiting flu-like illness to fulminant pneumonia, respiratory failure and death. Since DM and Covid 19 infection are closely associated with inflammatory status, mean platelet volume (MPV) was suggested to be useful in predicting Covid infection onset. This study aimed to evaluate the diagnostic role of MPV in Covid patients with diabetes. Methods A total of 640 subjects (160 Covid patients with type 2 diabetes, 160 healthy controls, 160 patients with non-spesific infections and 160 Covid patients without type 2 diabetes) enrolled in the study. Results MPV was significantly higher (11.21 ± 0.61 fL) as compared to the results from the last routine visits of the the same individuals with diabetes (10.59 ± 0.96 fL) (p = 0.000). Conclusions MPV could be used as a simple and cost-effective tool to predict the Covid infection in subjects with diabetes in primary care. url: https://www.ncbi.nlm.nih.gov/pubmed/32623037/ doi: 10.1016/j.diabres.2020.108294 id: cord-268939-ws74xprt author: Ozoner, Baris title: Neurosurgery Practice During Coronavirus Disease 2019 (COVID-19) Pandemic date: 2020-05-28 words: 5138.0 sentences: 391.0 pages: flesch: 46.0 cache: ./cache/cord-268939-ws74xprt.txt txt: ./txt/cord-268939-ws74xprt.txt summary: The increased burden has substantially impacted the neurosurgery practice and intensive modifications were required in surgical scheduling, inpatient and outpatient clinics, management of emergency cases, and even academic activities. Operations of COVID-19 positive patients, and emergency cases, where screening can not be obtained, should be performed following level 3 protective measures. [5] [6] [7] In neurosurgery practice, intensive modifications were required in surgical scheduling, administration of inpatient and outpatient clinics, management of emergency cases, and even academic & educational activities. 26 A recent study from Wuhan City, China reported that some severe COVID-19 patients developed neurologic manifestations, such as acute cerebrovascular diseases (5.7%), and impaired consciousness (14.8%). 76, 80 Also, a patient with a mass lesion in the sellar region that underwent endonasal endoscopic surgery in Neurosurgery Department, Tongji Medical College, Wuhan City, China was diagnosed with COVID-19 after surgery, and disease was confirmed in 14 healthcare professionals in the same clinic afterwards. abstract: Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly contagious, life-threatening condition with unprecedented impacts for worldwide societies and healthcare systems. Since the first detection in China, it has spread rapidly worldwide. The increased burden has substantially impacted the neurosurgery practice and intensive modifications were required in surgical scheduling, inpatient and outpatient clinics, management of emergency cases, and even academic activities. In some systems, non-overlapping teams were created to minimize transmission among healthcare workers. In case of a massive burden, neurosurgeons may be needed to reassign to the COVID-19 wards, or teams from other regions may be needed to send to severely affected areas. In outpatient practice, if possible, appointments should be turned into telemedicine. All staff assigned in the non-COVID treatment unit should be clothed in level 1 personal protective equipment. If possible, postponement is recommended for operations that do not require urgent or emergent intervention. All patients indicated for surgery must receive a COVID-19 screening, including nasopharyngeal swab, and thorax computed tomography. Level 2 protection measures would be appropriate during COVID-19 negative patients' operations. Operations of COVID-19 positive patients, and emergency cases, where screening can not be obtained, should be performed following level 3 protective measures. During surgery, the use of high-speed drills and electrocautery should be reduced to minimize aerosol production. Screening is crucial in all patients since the surgical outcome is highly mortal in COVID-19 patients. All educational and academic conferences can be turned into virtual webinars. url: https://api.elsevier.com/content/article/pii/S1878875020311669 doi: 10.1016/j.wneu.2020.05.195 id: cord-026025-xqj877en author: PETRAS, ROBERT E. title: Large Intestine (Colon) date: 2009-10-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271214/ doi: 10.1016/b978-1-4160-3966-2.00023-0 id: cord-308803-i934doud author: PONNAPA REDDY, M. title: Prone positioning of non-intubated patients with COVID-19 - A Systematic Review and Meta-analysis date: 2020-10-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Purpose: Several studies have reported adopting prone positioning (PP) in non-intubated patients with COVID-19-related hypoxaemic respiratory failure. This systematic review and meta-analysis evaluated the impact of PP on oxygenation and clinical outcomes. Methods: We searched PubMed, Embase and COVID-19 living systematic review from December1st 2019 to July23rd 2020. We included studies that reported using PP in hypoxaemic, non-intubated adult COVID-19 patients. Primary outcome measure was the weighted mean difference (MD) in oxygenation parameters (PaO2/FiO2, PaO2 or SpO2) pre and post-PP. Results: Fifteen single arm observational studies reporting PP in 449 patients were included. Substantial heterogeneity was noted in terms of, location within hospital where PP was instituted, respiratory supports, frequency and duration of PP. Significant improvement in oxygenation was reported post-PP: PaO2/FiO2, (MD 37.6, 95%CI 18.8, 56.5); PaO2, , (MD 30.4 mmHg, 95%CI 10.9, 49.9); and SpO2, (MD 5.8%, 95%CI 3.7, 7.9). Patients with a pre-PP PaO2/FiO2 [≤]150 experienced greater oxygenation improvements compared with those with a pre-PP PaO2/FiO2 >150 (MD 40.5, 95%CI -3.5, 84.6) vs. 37, 95%CI 17.1, 56.9). Respiratory rate decreased post-PP (MD -2.9, 95%CI -5.4, -0.4). Overall intubation and mortality rates were 21% (90/426) and 26% (101/390) respectively. No major adverse events were reported. Conclusions: Despite significant variability in frequency and duration of PP and respiratory supports, PP was associated with improvements in oxygenation parameters without any reported serious adverse events. Major limitation being lack of control arm and adjustment for confounders. Clinical trials are required to determine the effect of awake PP on patient-centred outcomes. url: http://medrxiv.org/cgi/content/short/2020.10.12.20211748v1?rss=1 doi: 10.1101/2020.10.12.20211748 id: cord-274494-heu6rmbt author: Pablos, Jose L title: Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases date: 2020-06-12 words: 3116.0 sentences: 170.0 pages: flesch: 36.0 cache: ./cache/cord-274494-heu6rmbt.txt txt: ./txt/cord-274494-heu6rmbt.txt summary: 10 11 Since timely obtaining methodologically rigorous data on the prevalence of severe SARS-CoV-2 infection in our patients under different therapies is challenging at this moment, 8 we have performed an exploratory analysis of the relative prevalence of hospital-diagnosed COVID-19 in large multicentric cohorts of rheumatic patients under follow-up. All aggregated groups of patients with AI/IMID showed higher rates of COVID-19, and analyses of the different groups confirmed increased prevalence in all diagnostic groups but SLE, where it was remarkably lower than those in the other groups and similar to that in the reference population (table 1 and figure 1 ). Our systematic approach identified a significant number of patients with different rheumatic conditions and immunomodulatory therapies with SARS-CoV-2 PCR-confirmed diagnosis that allowed us to describe the prevalence of hospital COVID-19 and to identify differences between diagnostic and therapeutic groups. abstract: BACKGROUND: The susceptibility of patients with rheumatic diseases and the risks or benefits of immunosuppressive therapies for COVID-19 are unknown. METHODS: We performed a retrospective study with patients under follow-up in rheumatology departments from seven hospitals in Spain. We matched updated databases of rheumatology patients with severe acute respiratory syndrome coronavirus 2-positive PCR tests performed in the hospital to the same reference populations. Rates of PCR+ confirmed COVID-19 were compared among groups. RESULTS: Patients with chronic inflammatory diseases had 1.32-fold higher prevalence of hospital PCR+ COVID-19 than the reference population (0.76% vs 0.58%). Patients with systemic autoimmune or immune-mediated disease (AI/IMID) showed a significant increase, whereas patients with inflammatory arthritis (IA) or systemic lupus erythematosus did not. COVID-19 cases in some but not all diagnostic groups had older ages than cases in the reference population. Patients with IA on targeted-synthetic or biological disease-modifying antirheumatic drugs (DMARDs), but not those on conventional-synthetic DMARDs, had a greater prevalence despite a similar age distribution. CONCLUSION: Patients with AI/IMID show a variable risk of hospital-diagnosed COVID-19. Interplay of ageing, therapies and disease-specific factors seem to contribute. These data provide a basis to improve preventive recommendations to rheumatic patients and to analyse the specific factors involved in COVID-19 susceptibility. url: https://doi.org/10.1136/annrheumdis-2020-217763 doi: 10.1136/annrheumdis-2020-217763 id: cord-350639-iguadmw1 author: Padlina, G title: Secondary Cerebrovascular Prevention in Light of the COVID-19 Pandemic date: 2020-08-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The COVID-19 pandemic has affected healthcare systems, professionals and patients around the world. At the same time, the burden of cerebrovascular events is considerable. Worldwide, more than one million deaths per year are due to cerebrovascular events, which are the second most frequent cause of death and the main cause of long-term disability in Europe. To approach the challenges of the COVID-19 pandemic and secondary cerebrovascular prevention: CONCLUSION: We recommend: (1) As in normal times, during the COVID-19 pandemic wave, patients need to seek urgent medical attention in case of any acute cerebrovascular event. This will assure they receive needed rapid cerebrovascular secondary prevention in addition to acute intravenous and endovascular reperfusion strategies. (2) As in normal times, during the COVID-19 pandemic wave, it is of utmost importance that patients adhere to their individual recommendations for secondary prevention. (3) Optimal secondary but also primary cerebrovascular prevention might reduce the burden of COVID-19 now and during potential subsequent waves. (4) Patients with cerebrovascular disease should strictly adhere to advice concerning the pandemic provided by their governments and to pandemic-related recommendations for them as individuals expressed by their treating physicians. url: https://www.ncbi.nlm.nih.gov/pubmed/32834715/ doi: 10.1007/s11940-020-00634-4 id: cord-350179-ltk5hfc4 author: Paganini, Matteo title: Translating COVID-19 Pandemic Surge Theory to Practice in the Emergency Department: How to Expand Structure date: 2020-03-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Multiple professional societies, nongovernment and government agencies have studied the science of sudden onset disaster mass casualty incidents to create and promote surge response guidelines. The COVID-19 pandemic has presented the health-care system with challenges that have limited science to guide the staff, stuff, and structure surge response. This study reviewed the available surge science literature specifically to guide an emergency department’s surge structural response using a translational science approach to answer the question: How does the concept of sudden onset mass casualty incident surge capability apply to the process to expand COVID-19 pandemic surge structure response? The available surge structural science literature was reviewed to determine the application to a pandemic response. The on-line ahead of print and print COVID-19 scientific publications, as well as gray literature were studied to learn the best available COVID-19 surge structural response science. A checklist was created to guide the emergency department team’s COVID-19 surge structural response. url: https://doi.org/10.1017/dmp.2020.57 doi: 10.1017/dmp.2020.57 id: cord-352177-05sku8a8 author: Pahus, Laurie title: Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials? date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Patient skepticism concerning medical innovations can have major consequences for current public health and may threaten future progress, which greatly relies on clinical research. The primary objective of this study is to determine the variables associated with patient acceptation or refusal to participate in clinical research. Specifically, we sought to evaluate if distrust in pharmaceutical companies and associated psychosocial factors could represent a recruitment bias in clinical trials and thus threaten the applicability of their results. METHODS: This prospective, multicenter survey consisted in the administration of a self-questionnaire to patients during a pulmonology consultation. The 1025 questionnaires distributed collected demographics, socio-professional and basic health literacy characteristics. Patients were asked to rank their level of trust for pharmaceutical companies and indicate their willingness to participate in different categories of research (pre or post marketing, sponsored by an academic institution or pharmaceutical company). Logistic regression was used to determine factors contributing to “trust” versus “distrust” group membership and willingness to participate in each category of research. RESULTS: One thousand patients completed the survey, corresponding to a response rate of 97.5%. Data from 838 patients were analyzed in this study. 48.3% of respondents declared that they trusted pharmaceutical companies, while 35.5% declared distrust. Being female (p = 0.042), inactive in the employment market(p = 0.007), and not-knowing the name of one’s disease(p = 0.010) are factors related to declared distrust. Distrust-group membership is associated with unwillingness to participate in certain categories of trials such as pre-marketing and industry-sponsored trials. CONCLUSION: Distrust in pharmaceutical companies is associated with a specific patient profile and with refusal to participate in certain subcategories of trials. This potential recruitment bias may explain the under-representation of certain categories of patients such as women in pre-marketing drug trials. url: https://www.ncbi.nlm.nih.gov/pubmed/32791969/ doi: 10.1186/s12910-020-00509-y id: cord-252279-0gozdv43 author: Pal, Amit title: Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update date: 2020-06-10 words: 3858.0 sentences: 207.0 pages: flesch: 39.0 cache: ./cache/cord-252279-0gozdv43.txt txt: ./txt/cord-252279-0gozdv43.txt summary: Without a therapeutic vaccine or specific antiviral drugs, and with a desperate attempt to find a cure against novel Corona Virus Disease 2019 (Covid-19) [1] , the limelight was shifted to hydoxychloroquine (derivative of chloroquine that has antimalarial, antiinflammatory, immunosuppressive and antiautophagy activities [2, 3] ; upon a tweet by US president Mr. Donald J. The main aim of this review is to discuss the mode of action of hydroxychloroquine at cellular and molecular levels, that potentially support the clinical efficacy and few adverse side effects observed in Covid-19 patients treated with hydroxychloroquine, which may further help in improving the clinical outcomes by modifying or altering the drug itself or its restricted use in certain individuals by enforcing strict inclusion and exclusion criteria. Due to its cellular and molecular effects as discussed in previous sections, quite a few clinical trials are studying the effectiveness and safety of hydroxychloroquine (also chloroquine) for Covid-19 (https://clinicaltrials.gov/ct2/ results?cond=%22wuhan?coronavirus%22). abstract: As the time for finding a definitive and safe cure as a vaccine for novel Corona Virus Disease 2019 (Covid-19) is still far, there is need to study in depth about the other potential drugs, which can save millions of lives due to Covid-19 pandemic. Right at the center of the debate is the use of drug “Hydroxychloroquine” as a prophylaxis as well as a treatment strategy against Covid-19 in conjunction with azithromycin. In this review, we will study the cellular and molecular aspects of hydroxychloroquine, which had driven its use in Covid-19 patients, as well as its chemistry and pharmacokinetics along with clinical trials going on worldwide using hydroxychloroquine against Covid-19. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12291-020-00900-x) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s12291-020-00900-x doi: 10.1007/s12291-020-00900-x id: cord-337898-ncrbd8rp author: Pal, Rimesh title: Comment on “Is the type of diabetes treatment relevant to outcome of COVID‐19?” date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32459882/ doi: 10.1111/1753-0407.13069 id: cord-281346-bjhdy8mg author: Palacios Cruz, M. title: COVID-19, a worldwide public health emergency() date: 2020-04-21 words: 3481.0 sentences: 190.0 pages: flesch: 51.0 cache: ./cache/cord-281346-bjhdy8mg.txt txt: ./txt/cord-281346-bjhdy8mg.txt summary: This new species of coronavirus has been termed 2019-nCoV and has caused a considerable number of cases of infection and deaths in China and, to a growing degree, beyond China, becoming a worldwide public health emergency. 2019-nCoV has high homology to other pathogenic coronaviruses, such as those originating from bat-related zoonosis (SARS-CoV), which caused approximately 646 deaths in China at the start of the decade. 17 Moreover, a recently published study estimated that 95% of the cases of 2019-nCoV infections in Wuhan showed symptoms before the 12th of January 2020, 18,19 a fact that, combined with the virus'' incubation period, suggests a high possibility of the disease''s travelrelated propagation. According to the WHO, a suspected case involves a patient with severe acute respiratory infection (fever, cough, requiring hospitalization) and with no other etiology that completely explains the clinical presentation, as well as a history of travel or residence in China during the 14 days before symptom onset. abstract: A new coronavirus outbreak emerged on the 31st of December 2019 in Wuhan, China, causing commotion among the medical community and the rest of the world. This new species of coronavirus has been termed 2019-nCoV and has caused a considerable number of cases of infection and deaths in China and, to a growing degree, beyond China, becoming a worldwide public health emergency. 2019-nCoV has high homology to other pathogenic coronaviruses, such as those originating from bat-related zoonosis (SARS-CoV), which caused approximately 646 deaths in China at the start of the decade. The mortality rate for 2019-nCoV is not as high (approximately 2–3%), but its rapid propagation has resulted in the activation of protocols to stop its spread. This pathogen has the potential to become a pandemic. It is therefore vital to follow the personal care recommendations issued by the World Health Organization. url: https://api.elsevier.com/content/article/pii/S2254887420300333 doi: 10.1016/j.rceng.2020.03.001 id: cord-253417-ihi67m1u author: Paleri, Vinidh title: Rapid implementation of an evidence‐based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow‐up after treatment during the COVID‐19 pandemic: Model for international collaboration date: 2020-05-11 words: 3533.0 sentences: 186.0 pages: flesch: 49.0 cache: ./cache/cord-253417-ihi67m1u.txt txt: ./txt/cord-253417-ihi67m1u.txt summary: title: Rapid implementation of an evidence‐based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow‐up after treatment during the COVID‐19 pandemic: Model for international collaboration The aim of this study is to demonstrate a rapid implementation of an evidence-based, structured, remote triaging system for assessment of suspected referrals and patients with cancer who are on regular follow-up after treatment for HNC in the United Kingdom (UK). Primary care practitioners'' views (12 general practitioners in the North East were interviewed face to face between June 14, 2019 and December 5, 2019) discussing the head and neck cancer risk calculator (version 1) as a means to drive more confidence in the triage of patients to suspected cancer clinics was met with enthusiasm. Rapid implementation of an evidence-based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow abstract: BACKGROUND: Outpatient telemedicine consultations are being adopted to triage patients for head and neck cancer. However, there is currently no established structure to frame this consultation. METHODS: For suspected referrals with cancer, we adapted the Head and Neck Cancer Risk Calculator (HaNC‐RC)‐V.2, generated from 10 244 referrals with the following diagnostic efficacy metrics: 85% sensitivity, 98.6% negative predictive value, and area under the curve of 0.89. For follow‐up patients, a symptom inventory generated from 5123 follow‐up consultations was used. A customized Excel Data Tool was created, trialed across professional groups and made freely available for download at http://www.entintegrate.co.uk/entuk2wwtt, alongside a user guide, protocol, and registration link for the project. Stakeholder support was obtained from national bodies. RESULTS: No remote consultations were refused by patients. Preliminary data from 511 triaging episodes at 13 centers show that 77.1% of patients were discharged directly or have had their appointments deferred. DISCUSSION: Significant reduction in footfall can be achieved using a structured triaging system. Further refinement of HaNC‐RC‐V.2 is feasible and the authors welcome international collaboration. url: https://doi.org/10.1002/hed.26219 doi: 10.1002/hed.26219 id: cord-307653-nyr6mtj1 author: Palmeira, Patricia title: Why is SARS-CoV-2 infection milder among children? date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.6061/clinics/2020/e1947 doi: 10.6061/clinics/2020/e1947 id: cord-033135-cxsmxk3b author: Palomo Cobos, Luis title: Chronicity and primary care in times of pandemic() date: 2020-10-03 words: 1796.0 sentences: 72.0 pages: flesch: 46.0 cache: ./cache/cord-033135-cxsmxk3b.txt txt: ./txt/cord-033135-cxsmxk3b.txt summary: 1 During the lockdown, primary care professionals reorganized to attend to mild cases at home and actively follow up people with greater vulnerability by phone, caring for their health and avoiding the complications that would require hospital admission. The current situation of the health crisis provoked by COVID-19 and the isolation measures imposed by the state of alarm decreed on 14th March led to the break-down of a series of routines and actions upon which the care of these patients was based, with their continued application being lost. An evaluation (Table 1 ) aimed at determining the functional, mental and social health situation of patients is therefore a way to detect possible changes or delays which occurred throughout lockdown and it is the necessary step before establishing new healthcare interventions, or the assignment of new resources and social-health resources and re-assessment. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532127/ doi: 10.1016/j.sedeng.2020.05.002 id: cord-284804-6i5zbmm1 author: Pan, Feng title: Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study date: 2020-05-18 words: 4632.0 sentences: 254.0 pages: flesch: 52.0 cache: ./cache/cord-284804-6i5zbmm1.txt txt: ./txt/cord-284804-6i5zbmm1.txt summary: Methods: In this case-control study, patients with severe COVID-19 in this newly established isolation center on admission between 27 January 2020 to 19 March 2020 were divided to discharge group and death event group. In the course, persistently lower lymphocyte with higher levels of CRP, PCT, IL-6, neutrophil, LDH, D-dimer, cardiac troponin I (cTnI), brain natriuretic peptide (BNP), and increased CD4+/CD8+ T-lymphocyte ratio and were observed in death events group, while these parameters stayed stable or improved in discharge group. The bivariate and multivariate logistic regressions were used to investigate the risk factors for death events involving the stratified clinical, radiographic, and laboratory parameters with significant differences between two groups on admission, and the odds ratio (OR) with 95% confidence interval (95%CI) were calculated. Besides, more abnormities of biochemical and hematological parameters were observed in death event group compared with discharge group, such as neutrophil, lymphocyte, CRP, PCT, LDH, D-dimer, cTnI, and BNP ( Table 2) . abstract: Rationale: Up to date, the exploration of clinical features in severe COVID-19 patients were mostly from the same center in Wuhan, China. The clinical data in other centers is limited. This study aims to explore the feasible parameters which could be used in clinical practice to predict the prognosis in hospitalized patients with severe coronavirus disease-19 (COVID-19). Methods: In this case-control study, patients with severe COVID-19 in this newly established isolation center on admission between 27 January 2020 to 19 March 2020 were divided to discharge group and death event group. Clinical information was collected and analyzed for the following objectives: 1. Comparisons of basic characteristics between two groups; 2. Risk factors for death on admission using logistic regression; 3. Dynamic changes of radiographic and laboratory parameters between two groups in the course. Results: 124 patients with severe COVID-19 on admission were included and divided into discharge group (n=35) and death event group (n=89). Sex, SpO2, breath rate, diastolic pressure, neutrophil, lymphocyte, C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), and D-dimer were significantly correlated with death events identified using bivariate logistic regression. Further multivariate logistic regression demonstrated a significant model fitting with C-index of 0.845 (p<0.001), in which SpO2≤89%, lymphocyte≤0.64×10(9)/L, CRP>77.35mg/L, PCT>0.20μg/L, and LDH>481U/L were the independent risk factors with the ORs of 2.959, 4.015, 2.852, 3.554, and 3.185, respectively (p<0.04). In the course, persistently lower lymphocyte with higher levels of CRP, PCT, IL-6, neutrophil, LDH, D-dimer, cardiac troponin I (cTnI), brain natriuretic peptide (BNP), and increased CD4+/CD8+ T-lymphocyte ratio and were observed in death events group, while these parameters stayed stable or improved in discharge group. Conclusions: On admission, the levels of SpO2, lymphocyte, CRP, PCT, and LDH could predict the prognosis of severe COVID-19 patients. Systematic inflammation with induced cardiac dysfunction was likely a primary reason for death events in severe COVID-19 except for acute respiratory distress syndrome. url: https://www.ncbi.nlm.nih.gov/pubmed/32547323/ doi: 10.7150/ijms.46614 id: cord-323446-w2ci1bfr author: Pan, Feng title: Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia date: 2020-02-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Chest CT is used to assess the severity of lung involvement in COVID-19 pneumonia. PURPOSE: To determine the change in chest CT findings associated with COVID-19 pneumonia from initial diagnosis until patient recovery. MATERIALS AND METHODS: This retrospective review included patients with RT-PCR confirmed COVID-19 infection presenting between 12 January 2020 to 6 February 2020. Patients with severe respiratory distress and/ or oxygen requirement at any time during the disease course were excluded. Repeat Chest CT was obtained at approximately 4 day intervals. The total CT score was the sum of lung involvement (5 lobes, score 1-5 for each lobe, range, 0 none, 25 maximum) was determined. RESULTS: Twenty one patients (6 males and 15 females, age 25-63 years) with confirmed COVID-19 pneumonia were evaluated. These patients under went a total of 82 pulmonary CT scans with a mean interval of 4±1 days (range: 1-8 days). All patients were discharged after a mean hospitalized period of 17±4 days (range: 11-26 days). Maximum lung involved peaked at approximately 10 days (with the calculated total CT score of 6) from the onset of initial symptoms (R2=0.25), p<0.001). Based on quartiles of patients from day 0 to day 26 involvement, 4 stages of lung CT were defined: Stage 1 (0-4 days): ground glass opacities (GGO) in 18/24 (75%) patients with the total CT score of 2±2; (2)Stage-2 (5-8d days): increased crazy-paving pattern 9/17 patients (53%) with a increase in total CT score (6±4, p=0.002); (3) Stage-3 (9-13days): consolidation 19/21 (91%) patients with the peak of total CT score (7±4); (4) Stage-4 (≥14 days): gradual resolution of consolidation 15/20 (75%) patients with a decreased total CT score (6±4) without crazy-paving pattern. CONCLUSION: In patients recovering from COVID-19 pneumonia (without severe respiratory distress during the disease course), lung abnormalities on chest CT showed greatest severity approximately 10 days after initial onset of symptoms. url: https://doi.org/10.1148/radiol.2020200370 doi: 10.1148/radiol.2020200370 id: cord-318369-y3wtfqrn author: Pan, Lingai title: How to optimize the Radiology protocol during the global COVID-19 epidemic: Keypoints from Sichuan Provincial People's Hospital date: 2020-08-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Currently, the COVID-19 pneumonia epidemic is spreading worldwide. Pulmonary imaging plays an important role. The pulmonary imaging (chest computed tomography and Digital radiography) are indispensable for definitive diagnosis and reexamination. It should be noted that nosocomial infection is not uncommon. Many cases including health workers are infected. This is the experience of our radiology department's protocols during the outbreak, we used this protocol to cope with the COVID-19 in Sichuan Province， besides，there is zero infection for health workers during the whole epidemic. So, we would like to share our experience to other radiologists to avoid the nosocomial infection as low as possible. We have six key points for updating the protocol in the epidemic period of COVID-19: 1. Triage system: three-level triage, 2. Maximum Protection Principle, 3. Technical operation principle: careful, fast and stable, 4. Radiologist's Responsibility and Notice, 5. Disinfection measures of machine room, 6. Hospital information construction, network office, accelerate the sharing of imaging, and carry out MDT consultation. url: https://api.elsevier.com/content/article/pii/S0899707120302692 doi: 10.1016/j.clinimag.2020.07.008 id: cord-341284-jmqdnart author: Panagopoulos, Periklis title: Lopinavir/ritonavir as a third agent in the antiviral regimen for SARS-CoV-2 infection date: 2020-06-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Corona Virus Disease (CoVID-19) is an emerging public health problem rapidly spread globally. New treatment options for patients with severe symptoms and ways of reducing transmission in the community are taken into consideration. A retrospective study was conducted in the Department of Infectious Diseases of Alexandroupolis (Greece) including 16 patients with CoVID-19. They were classified into two groups, A and B. Group A received lopinavir/ritonavir as a third agent in the antiviral regimen, while group B did not. Lymphocytes were more significantly increased in patients of group A. Ferritin serum levels were also decreased significantly in these patients. Number of days needed for a first negative result of Real Time- Polymerase Chain Reaction (RT-PCR) was lower for Group A. The present study suggests that lopinavir/ritonavir may reduce the viral carriage in a shorter period of time compared with other antiviral regimens. Further studies are needed in order to evaluate the effectiveness of lopinavir/ritonavir in the treatment of patients with SARS-CoV-2 infection. url: https://doi.org/10.1080/1120009x.2020.1775424 doi: 10.1080/1120009x.2020.1775424 id: cord-317151-cxx5pcln author: Papa, Alfredo title: Covid-19 and the management of patients with inflammatory bowel disease: a practical decalogue for the post-pandemic phase date: 2020-10-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised several concerns for patients with chronic immune-mediated diseases, including inflammatory bowel disease (IBD). As the outbreak appears to be in the descending phase, at least in some part of the world, as in most European countries, guidance is urgently needed to provide optimal care for our IBD patients in order to gradually and safely reduce the gap in care that has been accumulated in the months of lockdown and to face all the backlogs. Therefore, we have provided a decalogue of practical recommendations for gastroenterologists to manage patients with IBD in the post-peak phase of the COVID-19 pandemic. They include all the aspects of IBD care, not only pharmacological ones but also endoscopy, surgery, psychological treatment, telemedicine, diagnostics and educational tasks provided by doctors and patient associations. url: https://doi.org/10.1177/1756284820968747 doi: 10.1177/1756284820968747 id: cord-016248-dxk0i6t7 author: Papa, Joey C. title: Extracorporeal Membrane Oxygenation date: 2009 words: 6907.0 sentences: 357.0 pages: flesch: 49.0 cache: ./cache/cord-016248-dxk0i6t7.txt txt: ./txt/cord-016248-dxk0i6t7.txt summary: Indications for support in patients with cardiac pathology are based on clinical signs of decreased peripheral perfusion, including hypotension, despite the administration of fl uid resuscitation and inotropes, oliguria (urine output < 0.5 ml/kg/h), an elevated arterial lactate, and a decreased SvO 2 . The advantages of VV and DLVV over VA ECMO include avoidance of arterial cannulation and permanent ligation of the carotid artery, maintaining pulsatile fl ow to the patient, continued blood fl ow to the lungs, and avoiding arterial emboli. Weaning and Decannulation: As the patient''s underlying process improves, less blood fl ow is required to pass through the ECMO circuit in order to maintain adequate tissue oxygenation. According to the 2005 ELSO registry, 13.2% of neonates and 43% of pediatric patients treated with ECMO for respiratory failure required the use of inotropes while on bypass. The incidence of acute renal failure was 10% in neonates and 14% in pediatric patients on ECMO for respiratory support, with 10-15% requiring hemofi ltration or dialysis. abstract: Extracorporeal Membrane Oxygenation (ECMO) is a life-saving technology that uses partial heart and lung bypass for extended periods. It is not a therapeutic modality, but rather a supportive tool that provides suf-fi cient gas exchange and perfusion for patients with acute, reversible cardiac or respiratory failure. This affords the patient's cardiopulmonary system time to rest, sparing them from the deleterious effects of traumatic mechanical ventilation and perfusion impairment. The Extracorporeal Life Support Organization (ELSO) was formed in 1989 by a collaboration of physicians, nurses, perfusionists, and scientists with an interest in ECMO. The group provides an international registry that collects data from almost all ECMO centers in the United States and throughout the world. At the end of 2005, ELSO registered nearly 30,000 neonatal and pediatric patients treated with ECMO for a variety of cardiopulmonary disorders with an overall survival rate of 66%. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120477/ doi: 10.1007/978-3-540-69560-8_32 id: cord-007818-jfp9uumb author: Papali, Alfred title: Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings date: 2019-02-09 words: 15059.0 sentences: 654.0 pages: flesch: 34.0 cache: ./cache/cord-007818-jfp9uumb.txt txt: ./txt/cord-007818-jfp9uumb.txt summary: Finally, so-called telemedicine in ICUs in resource-rich settings, mainly to solve the problem of physician shortages during nighttime hours and in some ICUs with low-intensity staffing [21] , has been shown to improve early identification of patients who deteriorate [22] and increases the number of interventions [23] , but the effect on ICU outcomes remains controversial [24] and costs of required technological infrastructure are high [25] . Despite the availability of specialty training programs in selected countries, regional data and the experience of the authors suggest that intensive care specialists are unavailable in many ICUs in resource-limited settings [40] . Dedicated courses in trauma and intensive care-and emergency medicine-related procedures improve knowledge in "best clinical practice" of healthcare professionals working in ICUs in resource-limited settings [56, 57] . abstract: In this chapter, we provide guidance on some basic structural requirements, focusing on organization, staffing, and infrastructure. We suggest a closed-format intensive care unit (ICU) with dedicated physicians and nurses, specifically trained in intensive care medicine whenever feasible. Regarding infrastructural components, a reliable electricity supply is essential, with adequate backup systems. Facilities for oxygen therapy are crucial, and the choice between oxygen concentrators, cylinders, and a centralized system depends on the setting. For use in mechanical ventilators, a centralized piped system is preferred. Facilities for proper hand hygiene are essential. Alcohol-based solutions are preferred, except in the context of Ebola virus disease (chloride-based solutions) and Clostridium difficile infection (soap and water). Availability of disposable gloves is important for self-protection; for invasive procedures masks, caps, sterile gowns, sterile drapes, and sterile gloves are recommended. Caring for patients with highly contagious infectious diseases requires access to personal protective equipment. Basic ICU equipment should include vital signs monitors and mechanical ventilators, which should also deliver noninvasive ventilator modes. We suggest that ICUs providing invasive ventilatory support have the ability to measure end-tidal carbon dioxide and if possible can perform blood gas analysis. We recommend availability of glucometers and capabilities for measuring blood lactate. We suggest implementation of bedside ultrasound as diagnostic tool. Finally, we recommend proper administration of patient data; suggest development of locally applicable bundles, protocols, and checklists for the management of sepsis; and implement systematic collection of quality and performance indicators to guide improvements in ICU performance. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124120/ doi: 10.1007/978-3-030-03143-5_3 id: cord-005692-n4vxazst author: Papazian, Laurent title: Ventilator-associated pneumonia in adults: a narrative review date: 2020-03-10 words: 10361.0 sentences: 448.0 pages: flesch: 27.0 cache: ./cache/cord-005692-n4vxazst.txt txt: ./txt/cord-005692-n4vxazst.txt summary: Empirical treatment takes into account the underlying disease and its severity, the presence of risk factors for multiple-drug-resistant pathogens (antibiotic therapy in the previous 90 days, hospital stay > 5 days, septic shock at VAP onset, ARDS prior to VAP onset, acute renal replacement therapy prior to VAP onset, previous colonization with MDR pathogen) and local pattern of antimicrobial susceptibility. While lower respiratory tract surveillance cultures may help to predict the involvement of MDR microorganisms in patients that develop VAP and thus decrease unnecessary broad-spectrum antibiotics use, there are no clear data that this strategy improves clinical outcomes or lowers costs [89, 90] . Subglottic secretion drainage has repeatedly been associated with lower VAP rates in both individual randomized trials and meta-analyses but does not appear to shorten the time to extubation, ICU length-of-stay, prevent ventilator-associated events, or lower mortality rates [94] . Effect of oropharyngeal povidone-iodine preventive oral care on ventilator-associated pneumonia in severely brain-injured or cerebral hemorrhage patients: a multicenter, randomized controlled trial abstract: Ventilator-associated pneumonia (VAP) is one of the most frequent ICU-acquired infections. Reported incidences vary widely from 5 to 40% depending on the setting and diagnostic criteria. VAP is associated with prolonged duration of mechanical ventilation and ICU stay. The estimated attributable mortality of VAP is around 10%, with higher mortality rates in surgical ICU patients and in patients with mid-range severity scores at admission. Microbiological confirmation of infection is strongly encouraged. Which sampling method to use is still a matter of controversy. Emerging microbiological tools will likely modify our routine approach to diagnosing and treating VAP in the next future. Prevention of VAP is based on minimizing the exposure to mechanical ventilation and encouraging early liberation. Bundles that combine multiple prevention strategies may improve outcomes, but large randomized trials are needed to confirm this. Treatment should be limited to 7 days in the vast majority of the cases. Patients should be reassessed daily to confirm ongoing suspicion of disease, antibiotics should be narrowed as soon as antibiotic susceptibility results are available, and clinicians should consider stopping antibiotics if cultures are negative. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095206/ doi: 10.1007/s00134-020-05980-0 id: cord-001879-bn7h0kcw author: Papiris, Spyros A title: Survival in Idiopathic pulmonary fibrosis acute exacerbations: the non-steroid approach date: 2015-12-14 words: 4829.0 sentences: 224.0 pages: flesch: 43.0 cache: ./cache/cord-001879-bn7h0kcw.txt txt: ./txt/cord-001879-bn7h0kcw.txt summary: In 2012 a randomized, double-blind, placebo-controlled trial based on an independent protocol reviewed by a committee appointed by the National Heart, Lung, and Blood Institute, and conducted in 25 clinical centers under the auspices of the Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet) was terminated prematurely when the interim analysis demonstrated that IPF patients treated with combination therapy with prednisone, azathioprine and N-acetylcysteine not only had no evidence of physiological or clinical benefit but presented significantly increased rate of hospitalizations, exacerbations and deaths compared to the placebo arm [5] . abstract: BACKGROUND: Idiopathic pulmonary fibrosis acute exacerbation (IPF-AE) constitutes IPF’s most devastating event, representing the unexpected superimposition of diffuse alveolar damage of unknown etiology. Guidelines recommend high-dose steroids treatment despite unproven benefit. We hypothesized that previous immunosuppression and the administration of high-dose steroids adversely affect IPF-AE outcome. METHODS: We studied all consecutive patients hospitalized in our department for IPF deterioration from 2007 to June 2013. Our protocol consisted of immediate cessation of immunosuppression (if any), best supportive care, broad-spectrum antimicrobials and thorough evaluation to detect reversible causes of deterioration. Patients were followed-up for survival; post-discharge none received immunosuppression. RESULTS: Twenty-four out of 85 admissions (28 %) fulfilled IPF-AE criteria. IPF-AE were analyzed both as unique events and as unique patients. As unique events 50 % survived; 3 out of 12 (25 %) in the group previously treated with immunosuppression whereas nine out of 12 (75 %) in the group not receiving immunosuppression (p = 0.041). As unique patients 35.3 % survived; 3 out of 6 (50 %) in the never treated group whereas three out of 11 (27.3 %) in the group receiving immunosuppression (p = 0.685). The history of immunosuppression significantly and adversely influenced survival (p = 0.035). Survival was greater in the never treated group compared to the immunosuppressed patients (p = 0.022). Post-discharge, our IPF-AE survivors had an 83 % 1-year survival. CONCLUSIONS: By applying the above mentioned protocol half of our patients survived. The history of immunosuppression before IPF-AE adversely influences survival. Avoiding steroids in IPF patients may favor the natural history of the disease even at the moment of its most devastating event. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678631/ doi: 10.1186/s12890-015-0146-4 id: cord-323180-3ih0i81s author: Pardo, Emmanuel title: Nutritional support for critically ill patients with COVID-19: New strategy for a new disease? date: 2020-10-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33059104/ doi: 10.1016/j.accpm.2020.10.002 id: cord-310976-24b3c3a4 author: Parikh, Neil R. title: Time-Driven Activity-Based Costing Analysis of Telemedicine Services in Radiation Oncology date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Health systems have increased telemedicine use during the SARS-CoV-2 outbreak to limit in-person contact. We used time-driven activity-based costing to evaluate the change in resource use associated with transitioning to telemedicine in a radiation oncology department. METHODS AND MATERIALS: Using a patient undergoing 28-fraction treatment as an example, process maps for traditional in-person and telemedicine-based workflows consisting of discrete steps were created. Physicians/physicists/dosimetrists and nurses were assumed to work remotely 3 days and 1 day per week, respectively. Mapping was informed by interviews and surveys of personnel, with cost estimates obtained from the department’s financial officer. RESULTS: Transitioning to telemedicine reduced provider costs by $586 compared with traditional workflow: $47 at consultation, $280 during treatment planning, $237 during on-treatment visits, and $22 during the follow-up visit. Overall, cost savings were $347 for space/equipment and $239 for personnel. From an employee perspective, the total amount saved each year by not commuting was $36,718 for physicians (7243 minutes), $19,380 for physicists (7243 minutes), $17,286 for dosimetrists (7210 minutes), and $5599 for nurses (2249 minutes). Patients saved $170 per treatment course. CONCLUSIONS: A modified workflow incorporating telemedicine visits and work-from-home capability conferred savings to a department as well as significant time and costs to health care workers and patients alike. url: https://doi.org/10.1016/j.ijrobp.2020.06.053 doi: 10.1016/j.ijrobp.2020.06.053 id: cord-018801-amet0wx4 author: Park, Caroline title: Care of the Patient with Liver Failure Requiring Transplantation date: 2018-05-04 words: 4703.0 sentences: 237.0 pages: flesch: 30.0 cache: ./cache/cord-018801-amet0wx4.txt txt: ./txt/cord-018801-amet0wx4.txt summary: Depending on acuity, patients with decompensated chronic or acute fulminant liver failure generally require preoperative intensive care unit admission to manage organ dysfunction. Depending on acuity, patients with decompensated chronic or acute fulminant liver failure generally require preoperative intensive care unit (ICU) admission to manage organ dysfunction. In patients that develop AKI post-liver transplantation, treatment includes the prevention of hypotension and decreased use of unnecessary blood products. Early postoperative infections in liver transplant patients are typically bacterial and related to the donor''s status (previous infections from advanced cirrhosis), the surgical procedure itself, prolonged use of invasive catheters, and duration of mechanical ventilation. The resulting lack of blood flow and developing ischemia and necrosis from hepatic artery thrombosis present with signs and symptoms similar to fulminant liver failure patients with elevated liver serum tests, coagulopathy, and severe metabolic acidosis. abstract: Patients undergo liver transplantation to address chronic liver failure, acute fulminant liver failure, or primary liver cancer. Depending on acuity, patients with decompensated chronic or acute fulminant liver failure generally require preoperative intensive care unit admission to manage organ dysfunction. Those with chronic liver failure are allocated an organ based on waiting list position determined by their local organ procurement organization (OPO). This position is dependent upon blood type and Model for End- Stage Liver Disease (MELD) score. These patients thus are critically ill and require preoperative ICU monitoring and care. Patients with hepatocellular carcinoma (HCC) who require liver transplantation are given a MELD exception and rarely require preoperative ICU care. The patient’s ability to undergo liver transplant in the setting of HCC is determined by the Milan criteria or the University of California, San Francisco (UCSF) criteria. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123773/ doi: 10.1007/978-3-319-71712-8_55 id: cord-315397-cm3mc7we author: Park, H. C. title: Clinical Outcome of Asymptomatic COVID-19 Infection Among a Large Nationwide Cohort of 5,621 Hospitalized Patients in Korea date: 2020-10-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We investigated clinical outcome of asymptomatic coronavirus disease 2019 (COVID-19) and identified risk factors associated with high patient mortality using Korean nationwide public database of 5,621 hospitalized patients. The mortality rate and admission rate to intensive care unit were compared between asymptomatic and symptomatic patients. The prediction model for patient mortality was developed through risk factor analysis among asymptomatic patients. The prevalence of asymptomatic COVID-19 infection was 25.8%. The mortality rates were not different between groups (3.3% vs. 4.5%, p=0.17). However, symptomatic patients were more likely to receive ICU care compared to asymptomatic patients (4.1% vs. 1.0%, p<0.0001). The age-adjusted Charlson comorbidity index score (CCIS) was the most potent predictor for patient mortality in asymptomatic patients. The clinicians should predict the risk of death by evaluating age and comorbidities but not the presence of symptoms. url: http://medrxiv.org/cgi/content/short/2020.10.25.20218982v1?rss=1 doi: 10.1101/2020.10.25.20218982 id: cord-324314-os1btxx1 author: Park, Jaehyeon title: Departments of Radiation Oncology Must Prepare for COVID-19 Outbreak date: 2020-04-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2452109420300877 doi: 10.1016/j.adro.2020.03.023 id: cord-261410-kb91eagd author: Park, Ji Young title: Clinical Features and Courses of Adenovirus Pneumonia in Healthy Young Adults during an Outbreak among Korean Military Personnel date: 2017-01-23 words: 3504.0 sentences: 205.0 pages: flesch: 43.0 cache: ./cache/cord-261410-kb91eagd.txt txt: ./txt/cord-261410-kb91eagd.txt summary: The clinical features of respiratory adenoviral infection among military personnel were described previously; however, HAdV pneumonia in immunocompetent individuals and risk factors of disease progression to severe pneumonia or acute respiratory failure have not been well studied. All military trainees or active duty members, but not officers, were eligible for enrollment if they were !18 years old and had been admitted to the study hospital for pneumonia, defined by acute respiratory symptoms (fever, cough, sputum, dyspnea, and pleuritic chest pain) and pulmonary infiltrates on chest X-rays or computed tomography (CT) scans. Most HAdV pneumonia patients were basic military trainees or personnel who had recently completed training; active duty service personnel were not usually affected, even during outbreak peaks. Our results show that an outbreak of HAdV pneumonia occurred in Korean military training centers and indicate that emergent-type HAdV-55 infections might have caused the outbreak. abstract: BACKGROUND: The number of pneumonia patients increased suddenly in Korean military hospitals in late December 2014, indicating the urgent need for an epidemic outbreak investigation. METHODS: We conducted a prospective study of pneumonia etiology among immunocompetent young adults admitted to Daejeon Armed Forces hospital. Patient blood and sputum samples were subjected to conventional culture, serology, and polymerase chain reaction tests for respiratory viruses and atypical pathogens. RESULTS: From January to May 2015, we enrolled 191 (189 male) adults with pneumonia; the mean age was 20.1 ± 1.3 years. Five patients had severe pneumonia, and one died. Pathogenic human adenoviruses were most common (HAdV, 153/191 [80.1%]), indicating a HAdV pneumonia outbreak. Genotyping of 35 isolates indicated that 34 matched HAdV-55 and one matched HAdV-2. HAdV pneumonia infected recruit trainees most frequently. High and prolonged fever, nasal congestion, sore throat, and pharyngeal inflammation were significantly more common in the HAdV pneumonia group, compared to patients with other or unknown causes of pneumonia. Only 12% of HAdV pneumonia patients displayed leukocytosis, whereas febrile leukopenia (62.7%) and thrombocytopenia (41%) were commonly observed. HAdV pneumonia patient chest CT scans displayed ground glass opacity (with or without septal thickness) with consolidation in 50.0% of patients. CONCLUSIONS: An outbreak of HAdV respiratory infection occurred at the Korean military training center. HAdV pneumonia exhibited specific laboratory and clinical features, and although most patients were cured without complication, some progressed to respiratory failure and fatality. Therefore, HAdV vaccine should be provided to military trainees in Korea. url: https://www.ncbi.nlm.nih.gov/pubmed/28114362/ doi: 10.1371/journal.pone.0170592 id: cord-268540-wrjzr3ws author: Park, You Jeong title: Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics date: 2020-08-13 words: 16363.0 sentences: 868.0 pages: flesch: 45.0 cache: ./cache/cord-268540-wrjzr3ws.txt txt: ./txt/cord-268540-wrjzr3ws.txt summary: A potential target for drug development for COVID-19 also involves inhibition of ACE2, the host cell receptor for the S protein of SARS-CoV-2 that is primed by TMPRSS2 protease and may prevent the entry of the virus. As previously described, the intermolecular interaction between the viral SP and human ACE2 Phase II CAStem cells will be intravenously injected into patients with or without acute respiratory distress syndrome (ARDS) induced by COVID-19. Phase II Patients with acute respiratory distress syndrome caused by COVID-19 will be treated with intravenous UC-MSCs at a dose 1 million xKg. Patient improvement will be evaluated over three weeks, along with the assessment of the immune profile, investigating the stem cells'' effect on the cytokine storm. The similarities in systemic multi-organ complications between H7N9 and Sars-Cov-2 infections, along with direct evidence of the benefits of MSCs transplantation for COVID-19, further supports the potential of stem cells as an effective treatment [138] . abstract: The human population is in the midst of battling a rapidly-spreading virus— Severe Acute Respiratory Syndrome Coronavirus 2, responsible for Coronavirus disease 2019 or COVID-19. Despite the resurgences in positive cases after reopening businesses in May, the country is seeing a shift in mindset surrounding the pandemic as people have been eagerly trickling out from federally-mandated quarantine into restaurants, bars, and gyms across America. History can teach us about the past, and today’s pandemic is no exception. Without a vaccine available, three lessons from the 1918 Spanish flu pandemic may arm us in our fight against COVID-19. First, those who survived the first wave developed immunity to the second wave, highlighting the potential of passive immunity-based treatments like convalescent plasma and cell-based therapy. Second, the long-term consequences of COVID-19 are unknown. Slow-progressive cases of the Spanish flu have been linked to bacterial pneumonia and neurological disorders later in life, emphasizing the need to reduce COVID-19 transmission. Third, the Spanish flu killed approximately 17 to 50 million people, and the lack of human response, overcrowding, and poor hygiene were key in promoting the spread and high mortality. Human behavior is the most important strategy for preventing the virus spread and we must adhere to proper precautions. This review will cover our current understanding of the pathology and treatment for COVID-19 and highlight similarities between past pandemics. By revisiting history, we hope to emphasize the importance of human behavior and innovative therapies as we wait for the development of a vaccine. [Figure: see text] url: https://www.ncbi.nlm.nih.gov/pubmed/32789802/ doi: 10.1007/s12015-020-10026-5 id: cord-350065-frg7gvf5 author: Parolari, Alessandro title: Safety for all: coronavirus disease 2019 pandemic and cardiac surgery: a roadmap to ‘phase’ 2 date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/ejcts/ezaa187 doi: 10.1093/ejcts/ezaa187 id: cord-261311-j6bmgmhz author: Parreiras Martins, Maria Auxiliadora title: Preparedness of pharmacists to respond to the emergency of the COVID-19 pandemic in Brazil: a comprehensive overview date: 2020-07-31 words: 4307.0 sentences: 206.0 pages: flesch: 37.0 cache: ./cache/cord-261311-j6bmgmhz.txt txt: ./txt/cord-261311-j6bmgmhz.txt summary: COVID-19 patients may present high risk in the use of medications and clinical pharmacists can contribute substantially as part of a multidisciplinary team to improve outcomes in drug therapy in severe and critical illness. The course of an intense inflammatory process leads to alterations in many Review of patients'' medical history Provision of real-time assessment and evidence-based (when possible) advice on drug therapy Support on safe use of medications brought from home Medication reconciliation at different levels of transition of care Simplification of drug administration schedule to reduce the exposure of nurses to COVID-19 patients Monitoring of potential drug-drug, drug-food interactions and adverse drug reactions Adjustments in dosing regimens according to liver and kidney functions Prevention of medication errors Optimization of drug therapy and electrolytes to minimize the risk of prolonged corrected QT intervals and torsade de pointes Support on lung-protective ventilation and neuromuscular blocking agents to facilitate ventilator synchrony Provision of conservative fluid strategies and monitoring of vasopressors use Monitoring of empirical antibiotics for suspected bacterial co-infection with rigorous de-escalation Employment of FASTHUG-MAIDENS mnemonic to identify drug-related problems in intensive care units Support on drug information to patients and multidisciplinary teams, following biosafety protocols Considerations on special situations (pediatrics, older adults, people with chronic diseases, allergies) Research and continuing education Precise documentation of pharmaceutical interventions laboratory tests in patients with acute or severe/critical illness. abstract: The outbreak of COVID-19 in low- and middle-income countries is worrisome due to the social inequalities in these countries, their limited health budgets and the significant burden of other acute and chronic diseases. The leap in the number of cases in Brazil has imposed a huge strain on the healthcare system. We sought to provide a comprehensive overview of the challenges encountered by pharmacy services in responding to the COVID-19 pandemic emergency in Brazil and discuss the role of clinical pharmacists in this context. Pharmaceutical services play a key role in the emergency response to the pandemic. The pharmacy workforce has been actively working to manage drug shortages, redesign workflow, and review drug formularies/protocols to improve safety for patients and healthcare professionals (HCPs). COVID-19 patients may present high risk in the use of medications and clinical pharmacists can contribute substantially as part of a multidisciplinary team to improve outcomes in drug therapy in severe and critical illness. The participation of pharmacists as members of antimicrobial stewardship programs should be enhanced to ensure appropriate and safe use of antibiotics in this context. HCPs should be encouraged to seek improvements in the performance of pharmaceutical services and innovative practices to respond to the pandemic. Further studies are needed to generate knowledge on COVID-19 to improve patient care in vulnerable populations. url: https://www.ncbi.nlm.nih.gov/pubmed/32837194/ doi: 10.1007/s40267-020-00761-7 id: cord-013380-1jwzbgwb author: Parrilla, Claudio title: A one-year time frame for voice prosthesis management. What should the physician expect? Is it an overrated job? date: 2020-08-17 words: 3406.0 sentences: 205.0 pages: flesch: 47.0 cache: ./cache/cord-013380-1jwzbgwb.txt txt: ./txt/cord-013380-1jwzbgwb.txt summary: The management of these issues is considered time demanding, often causes anxiety in non-experienced non-specifically trained specialists and, in the real world, it represents the main obstacle for many physicians to voice prosthesis rehabilitation. The aim of this paper is to analyse a 1-year window of troubleshooting in a multidisciplinary setting for a large cohort of voice prosthesis rehabilitated patients, to quantify how demanding management is and to propose an algorithm that is useful to minimise the time and burden for dedicated clinicians. To address the first issue, we analysed a 1-year time frame of management in a large cohort of voice prosthesis rehabilitated patients and, as a result, we developed a trouble-shooting algorithm with a technical flow chart to achieve quick and correct identification and adequate treatment of complications (Fig. 1) . Our study highlights the importance of a systematic approach in the management of late complications in voice prosthesis rehabilitated patients. abstract: Management of late complications represents the main reason for reluctance in using voice prosthesis rehabilitation. The aim of this paper is to report our experience by describing the one-year management of a large cohort of patients in order to clarify how demanding management is in terms of burden on clinicians. Between June 2017 and June 2018, each access made at the Otolaryngology Clinic of our Institute for issues related to prosthesis by 70 laryngectomised patients rehabilitated by voice prosthesis was registered in a specific database. A review of the data provided information on the incidence, management and outcomes of adverse events encountered during the selected time frame. In addition, a T test was used to evaluate the differences between irradiated and non-irradiated patients and between primary and secondary tracheo-oesophageal-puncture. Leakage through the prosthesis was the most common cause for access (51.86%). The median number of accesses per patient per year was 3.47. The speech therapist autonomously managed 18.1% of accesses. The median number of accesses per patient per year needing a physician was 2.84. The median lifetime of the prosthesis was 4.85 months. Radiotherapy or modality (primary or secondary) of the puncture did not influence the number of accesses per year or the prosthesis lifetime. This retrospective analysis of results highlighted the most frequent issues and the most effective measures to deal with them, which allowed us to define a systematic algorithm to standardise and ease long-term outpatient management. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586190/ doi: 10.14639/0392-100x-n0587 id: cord-304255-7xs9cit7 author: Parrish, Richard K. title: What Does Telemedicine Mean for the Care of Patients With Glaucoma in the Age of COVID-19? date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S0002939420303962 doi: 10.1016/j.ajo.2020.07.038 id: cord-285298-r7p44wpe author: Parsonage, William A. title: CSANZ Position Statement on the Evaluation of Patients Presenting With Suspected Acute Coronary Syndromes During the COVID-19 Pandemic # date: 2020-05-21 words: 2141.0 sentences: 112.0 pages: flesch: 45.0 cache: ./cache/cord-285298-r7p44wpe.txt txt: ./txt/cord-285298-r7p44wpe.txt summary: The position statement complements, and should be read in conjunction with, the National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016: Section 2 ''Assessment of Possible Cardiac Chest Pain''. • Early identification of low risk patients who do not require further testing for ischaemia, either by 1) Using a single test of serum troponin level on presentation, or 2) Clinical risk stratification and serial testing of ECG and troponin only • Identification of low risk patients who can safely be discharged from ED with expedited out-patient review and consideration of further testing Whilst these criteria can be used on an individual patient basis, substantial ''system wide'' gains are possible using a strategic approach to chest pain assessment [4] . abstract: Abstract A pandemic of Coronavirus-19 disease was declared by the World Health Organization on March 11, 2020. The pandemic is expected to place unprecedented demand on health service delivery. This position statement has been developed by the Cardiac Society of Australia and New Zealand to assist clinicians to continue to deliver rapid and safe evaluation of patients presenting with suspected acute cardiac syndrome at this time. The position statement complements, and should be read in conjunction with, the National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016: Section 2 ‘Assessment of Possible Cardiac Chest Pain’. url: https://www.ncbi.nlm.nih.gov/pubmed/32601022/ doi: 10.1016/j.hlc.2020.05.003 id: cord-309829-3dlfcy31 author: Parupudi, Tejasvi title: Evidence-based point-of-care technology development during the COVID-19 pandemic date: 2020-11-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Since December 2019, the SARS-CoV-2 outbreak that began in Wuhan, China has spread to nearly every continent and become a global health concern. Although much has been discovered about COVID-19 and its pathogenesis, the WHO has identified an immediate need to increase the levels of testing for COVID-19 and identify the stages of the disease accurately for appropriate action to be taken by clinicians and emergency care units. Harnessing technology for accurate diagnosis and staging will improve patient outcomes and minimize serious consequences of false-positive test results. Point-of-care technologies aim to intervene at every stage of the disease to quickly identify infected patients and asymptomatic carriers and stratify them for timely treatment. This requires the tests to be rapid, accurate, sensitive, simple to use and compatible with many body fluids. Mobile platforms are optimal for remote, small-scale deployment, whereas facility-based platforms at hospital centers and laboratory settings offer higher throughput. Here we review evidence-based point-of-care technologies in the context of the entire continuum of COVID-19, from early screening to treatment, and discuss their impact on improving patient outcomes. url: https://doi.org/10.2144/btn-2020-0096 doi: 10.2144/btn-2020-0096 id: cord-336390-ptnpgh3j author: Passamonti, Francesco title: Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Summary Background Several small studies on patients with COVID-19 and haematological malignancies are available showing a high mortality in this population. The Italian Hematology Alliance on COVID-19 aimed to collect data from adult patients with haematological malignancies who required hospitalisation for COVID-19. Methods This multicentre, retrospective, cohort study included adult patients (aged ≥18 years) with diagnosis of a WHO-defined haematological malignancy admitted to 66 Italian hospitals between Feb 25 and May 18, 2020, with laboratory-confirmed and symptomatic COVID-19. Data cutoff for this analysis was June 22, 2020. The primary outcome was mortality and evaluation of potential predictive parameters of mortality. We calculated standardised mortality ratios between observed death in the study cohort and expected death by applying stratum-specific mortality rates of the Italian population with COVID-19 and an Italian cohort of 31 993 patients with haematological malignancies without COVID-19 (data up to March 1, 2019). Multivariable Cox proportional hazards model was used to identify factors associated with overall survival. This study is registered with ClinicalTrials.gov, NCT04352556, and the prospective part of the study is ongoing. Findings We enrolled 536 patients with a median follow-up of 20 days (IQR 10–34) at data cutoff, 85 (16%) of whom were managed as outpatients. 440 (98%) of 451 hospitalised patients completed their hospital course (were either discharged alive or died). 198 (37%) of 536 patients died. When compared with the general Italian population with COVID-19, the standardised mortality ratio was 2·04 (95% CI 1·77–2·34) in our whole study cohort and 3·72 (2·86–4·64) in individuals younger than 70 years. When compared with the non-COVID-19 cohort with haematological malignancies, the standardised mortality ratio was 41·3 (38·1–44·9). Older age (hazard ratio 1·03, 95% CI 1·01–1·05); progressive disease status (2·10, 1·41–3·12); diagnosis of acute myeloid leukaemia (3·49, 1·56–7·81), indolent non-Hodgin lymphoma (2·19, 1·07–4·48), aggressive non-Hodgkin lymphoma (2·56, 1·34–4·89), or plasma cell neoplasms (2·48, 1·31–4·69), and severe or critical COVID-19 (4·08, 2·73–6·09) were associated with worse overall survival. Interpretation This study adds to the evidence that patients with haematological malignancies have worse outcomes than both the general population with COVID-19 and patients with haematological malignancies without COVID-19. The high mortality among patients with haematological malignancies hospitalised with COVID-19 highlights the need for aggressive infection prevention strategies, at least until effective vaccination or treatment strategies are available. Funding Associazione italiana contro le leucemie, linfomi e mieloma–Varese Onlus. url: https://www.sciencedirect.com/science/article/pii/S2352302620302519 doi: 10.1016/s2352-3026(20)30251-9 id: cord-346061-pbghgitg author: Passanisi, Stefano title: Quarantine Due to the COVID-19 Pandemic From the Perspective of Pediatric Patients With Type 1 Diabetes: A Web-Based Survey date: 2020-07-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: A crucial aspect of the 2019 coronavirus disease (COVID-19) pandemic was the psychological impact on the population. Most countries issued restrictive laws to reduce community-based viral spread. Children and adolescents were forced to experience physical and social distancing. Subjects with chronic diseases, such as type 1 diabetes, were more vulnerable and at higher risk of developing psychological disorders. Methods: We conducted a web-based survey to investigate the behavioral responses during quarantine due to the COVID-19 outbreak in a cohort of pediatric patients with type 1 diabetes. Data were collected on demographic and clinical characteristics, lifestyle changes, and the impact of COVID-19 on the management of diabetes. Results: Two hundred four pediatric patients (aged 5–18 years) with type 1 diabetes completed the questionnaire. Interestingly, patients ≤12 years were significantly more influenced by the quarantine period in their approach to the disease than older patients. Conclusion: Although quarantine was a stressful psychological condition, our results showed that most children and adolescents with type 1 diabetes developed high levels of resilience and excellent coping skills by using technology in a proper way. url: https://doi.org/10.3389/fped.2020.00491 doi: 10.3389/fped.2020.00491 id: cord-260224-1aeqe7fh author: Passerini, Matteo title: Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak date: 2020-05-23 words: 2000.0 sentences: 99.0 pages: flesch: 43.0 cache: ./cache/cord-260224-1aeqe7fh.txt txt: ./txt/cord-260224-1aeqe7fh.txt summary: A 61-year-old male patient affected by stage IV prostate cancer with bone metastasis at diagnosis presented to our Wound Care Clinic complaining of ulcers on the right forearm that appeared two weeks prior following a referred domestic trauma. He presented no signs and symptoms of recrudescence of cutaneous and neurological cryptococcosis, but the cryptococcal antigen was still positive. There is no typical cutaneous lesion of cryptococcosis, but skin involvement is typically characterized by various non-specific presentations (e.g., papules, pustules, nodules, abscesses, edema, panniculitis, and ulcers) and can be due to a primary infection or due to a secondary systemic hematogenous spread [8] [9] [10] . Our patient presented with two large and necrotic ulcers on his right forearm and was treated with broad-spectrum antibiotics. The studies cited above and the clinical course of our patient showed that cutaneous symptoms in an immunocompromised patient should always alert about the possibility of an opportunistic infection such as cryptococcosis. abstract: We report the case of a 61-year-old patient with a history of prostate cancer affected by bone metastasis. He presented to our attention for ulcerous and necrotic cutaneous lesions unresponsive to antibiotics. The spread of cutaneous lesions and the onset of neurological symptoms suggested a cryptococcal disease, which was confirmed by lumbar puncture and cutaneous biopsy. We present the diagnostic and therapeutic approach to this case. url: https://www.ncbi.nlm.nih.gov/pubmed/32596073/ doi: 10.7759/cureus.8254 id: cord-018209-v2crgj5w author: Pastores, Stephen M. title: What Has Been Learned from Postmortem Studies? date: 2010-08-19 words: 5270.0 sentences: 327.0 pages: flesch: 31.0 cache: ./cache/cord-018209-v2crgj5w.txt txt: ./txt/cord-018209-v2crgj5w.txt summary: Infectious and noninfectious pulmonary complications occur in 30-60% of patients with hematological malignancy and recipients of hematopoietic stem cell transplantation (HSCT) and are associated with signifi cant morbidity and mortality [1] . This chapter will review the infectious and noninfectious pulmonary findings that have been described at autopsy in patients with hematological malignancies, including blood and bone marrow transplant recipients. Table 20 .1 lists the infectious and non-infectious pulmonary disorders reported in autopsy studies of patients with hematologic malignancy, including HSCT recipients. Several autopsy series have reported diagnostic discrepancies between premortem clinical diagnosis and postmortem autopsy findings ranging from 5% to 64% in patients with hematologic malignancy and HSCT recipients (Table 20. Infectious and noninfectious pulmonary diseases are commonly found on postmortem autopsy studies in patients with hematological malignancy and HSCT recipients. Major diagnostic discrepancies between clinical premortem diagnoses and postmortem autopsy findings have been reported in patients with hematologic malignancy. abstract: Infectious and noninfectious pulmonary diseases are commonly found on postmortem autopsy studies in patients with hematological malignancy. Despite the technological advances in diagnostic testing and imaging modalities, obtaining an accurate clinical diagnosis remains difficult and often not possible until autopsy. Major diagnostic discrepancies between clinical premortem diagnoses and postmortem autopsy findings have been reported in these patients. The most common missed diagnoses are due to opportunistic infections and cardiopulmonary complications. These findings underscore the importance of enhanced surveillance, monitoring and treatment of infections and cardiopulmonary disorders in these patients. Autopsies remain important in determining an accurate cause of death and for improved understanding of diagnostic deficiencies, as well as for medical education and quality assurance. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123032/ doi: 10.1007/978-3-642-15742-4_20 id: cord-034898-zjfhpum2 author: Patangi, Sanjay Orathi title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective date: 2020-11-07 words: 7527.0 sentences: 448.0 pages: flesch: 39.0 cache: ./cache/cord-034898-zjfhpum2.txt txt: ./txt/cord-034898-zjfhpum2.txt summary: title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ''post-cardiotomy cardiogenic shock'' — A review with an Indian perspective Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an important modality of managing post-cardiotomy cardiogenic shock with variable outcomes which would otherwise be universally fatal. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has gained popularity over the years as a ''bailout'' option after conventional circulatory support methods have proved refractory in the operating room (OR)/intensive care unit (ICU). Long-term survival and major outcomes in post-cardiotomy extracorporeal membrane oxygenation for adult patients in cardiogenic shock Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation Clinical outcomes in patients after extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock: a single-centre experience of 92 cases abstract: The ultimate goals of cardiovascular physiology are to ensure adequate end-organ perfusion to satisfy the local metabolic demand, to maintain homeostasis and achieve ‘milieu intérieur’. Cardiogenic shock is a state of pump failure which results in tissue hypoperfusion and its associated complications. There are a wide variety of causes which lead to this deranged physiology, and one such important and common scenario is the post-cardiotomy state which is encountered in cardiac surgical units. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an important modality of managing post-cardiotomy cardiogenic shock with variable outcomes which would otherwise be universally fatal. VA-ECMO is considered as a double-edged sword with the advantages of luxurious perfusion while providing an avenue for the failing heart to recover, but with the problems of anticoagulation, inflammatory and adverse systemic effects. Optimal outcomes after VA-ECMO are heavily reliant on a multitude of factors and require a multi-disciplinary team to handle them. This article aims to provide an insight into the pathophysiology of VA-ECMO, cannulation techniques, commonly encountered problems, monitoring, weaning strategies and ethical considerations along with a literature review of current evidence-based practices. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647874/ doi: 10.1007/s12055-020-01051-7 id: cord-344709-5hy1e4t1 author: Patel, Brijesh V. title: Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations date: 2020-09-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Rationale: Clinical and epidemiologic data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address the underlying pathophysiology. Objectives: To ascertain the physiologic, hematologic, and imaging basis of lung injury in severe COVID-19 pneumonia. Methods: Clinical, physiologic, and laboratory data were collated. Radiologic (computed tomography (CT) pulmonary angiography [n = 39] and dual-energy CT [DECT, n = 20]) studies were evaluated: observers quantified CT patterns (including the extent of abnormal lung and the presence and extent of dilated peripheral vessels) and perfusion defects on DECT. Coagulation status was assessed using thromboelastography. Measurements and Results: In 39 consecutive patients (male:female, 32:7; mean age, 53 ± 10 yr [range, 29–79 yr]; Black and minority ethnic, n = 25 [64%]), there was a significant vascular perfusion abnormality and increased physiologic dead space (dynamic compliance, 33.7 ± 14.7 ml/cm H(2)O; Murray lung injury score, 3.14 ± 0.53; mean ventilatory ratios, 2.6 ± 0.8) with evidence of hypercoagulability and fibrinolytic “shutdown”. The mean CT extent (±SD) of normally aerated lung, ground-glass opacification, and dense parenchymal opacification were 23.5 ± 16.7%, 36.3 ± 24.7%, and 42.7 ± 27.1%, respectively. Dilated peripheral vessels were present in 21/33 (63.6%) patients with at least two assessable lobes (including 10/21 [47.6%] with no evidence of acute pulmonary emboli). Perfusion defects on DECT (assessable in 18/20 [90%]) were present in all patients (wedge-shaped, n = 3; mottled, n = 9; mixed pattern, n = 6). Conclusions: Physiologic, hematologic, and imaging data show not only the presence of a hypercoagulable phenotype in severe COVID-19 pneumonia but also markedly impaired pulmonary perfusion likely caused by pulmonary angiopathy and thrombosis. url: https://www.ncbi.nlm.nih.gov/pubmed/32667207/ doi: 10.1164/rccm.202004-1412oc id: cord-323809-bocidwg4 author: Patel, Dhwanil title: COVID-19 EXTRAPULMONARY ILLNESS - The Impact of COVID-19 on Nephrology Care date: 2020-07-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease-2019 (COVID-19) has caused a pandemic that has affected millions of people worldwide. COVID-19 is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and is spread by close contact and by respiratory droplets. It has also impacted different aspects of caring for people with kidney disease, including those with acute kidney injury (AKI), chronic kidney disease (CKD), those requiring kidney replacement therapy (KRT), and those with a kidney transplant. All of these patients are considered high risk. The lessons learned from the COVID-19 pandemic will hopefully serve to protect patients with kidney disease in a similar situation in the future. url: https://www.ncbi.nlm.nih.gov/pubmed/32758363/ doi: 10.1016/j.disamonth.2020.101057 id: cord-276090-n8c2jpr6 author: Patel, Hiren N. title: Cerebellar Infarction Requiring Surgical Decompression in patient with COVID 19 Pathological Analysis, Brief Review date: 2020-07-29 words: 2871.0 sentences: 162.0 pages: flesch: 41.0 cache: ./cache/cord-276090-n8c2jpr6.txt txt: ./txt/cord-276090-n8c2jpr6.txt summary: CONCLUSION: A young man with COVID-19 and suspected immune dysregulation, complicated by a large cerebrovascular ischemic stroke secondary to vertebral artery thrombosis requiring emergent neurosurgical intervention for decompression with improved neurological outcomes. angiography, CXR denotes chest X-ray, FiO2 denotes fraction of inspired oxygen, SARS-COV-2 denotes severe acute respiratory syndrome coronavirus 2, STAT denotes statum which is Latin meaning immediately, t-PA denotes tissue plasminogen activator, WHO denotes World Health Organization. A young man with COVID-19 and suspected immune dysregulation, complicated by a large cerebrovascular ischemic stroke secondary to vertebral artery thrombosis requiring emergent neurosurgical intervention for decompression with improved neurological outcomes. COVID-19 complicated with cerebral and large vessel vasculitis and its treatment will require a need for randomized clinical trials showing benefit in outcomes and mortality. This is a report of a patient with COVID-19 immune dysregulation who developed an acute cerebellar ischemic stroke secondary to vertebral artery thrombosis. abstract: BACKGROUND: This report and literature review describes a case of a COVID-19 patient who suffered a cerebellar stroke requiring neurosurgical decompression. This is the first reported case of a sub-occipital craniectomy with brain biopsy in a COVID-19 patient showing leptomeningeal venous intimal inflammation. CLINICAL DESCRIPTION: The patient is a 48-year-old SARS-COV-2 positive male with multiple comorbidities, who presented with fevers and respiratory symptoms, and imaging consistent with multifocal pneumonia. On day 5 of admission, the patient had sudden change in mental status, increased C-Reactive Protein, ferritin and elevated Interleukin-6 levels. Head CT showed cerebral infarction from vertebral artery occlusion. Given subsequent rapid neurologic decline from cerebellar swelling and mass effect on his brainstem emergent neurosurgical intervention was performed. Brain biopsy found a vein with small organizing thrombus adjacent to focally proliferative intima with focal intimal neutrophils. CONCLUSION: A young man with COVID-19 and suspected immune dysregulation, complicated by a large cerebrovascular ischemic stroke secondary to vertebral artery thrombosis requiring emergent neurosurgical intervention for decompression with improved neurological outcomes. Brain biopsy was suggestive of inflammation from thrombosed vessel, and neutrophilic infiltration of cerebellar tissue. url: https://www.sciencedirect.com/science/article/pii/S2214751920304114?v=s5 doi: 10.1016/j.inat.2020.100850 id: cord-350594-0zxq4lxc author: Patel, Ishan title: Life-Threatening Psoas Hematoma due to Retroperitoneal Hemorrhage in a COVID-19 Patient on Enoxaparin Treated With Arterial Embolization: A Case Report date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Respiratory failure is presumptively caused by microvascular thrombosis in some patients with coronavirus disease 2019 (COVID-19) requiring therapeutic anticoagulation. Anticoagulation treatment may cause life-threatening bleeding complications such as retroperitoneal hemorrhage. To the best of our knowledge, we report first case of a COVID-19 patient treated with therapeutic anticoagulation resulting in psoas hematoma due to lumbar artery bleeding. A 69-year-old patient presented with fever, malaise and progressive shortness of breath to our hospital. He was diagnosed with COVID-19 by RT-PCR. Due to an abnormal coagulation profile, the patient was started on enoxaparin. Over the course of hospitalization, the patient was found to have hypotension with worsening hemoglobin levels. Computed tomography scan of the abdomen and pelvis revealed a large psoas hematoma. Arteriogram revealed lumbar artery bleeding which was treated with embolization. Anticoagulation therapy, while indicated in COVID-19 patients, has its own challenges and guidelines describing dosages and indications in this disease are lacking. Rare bleeding complications such as psoas hematoma should be kept in mind in patients who become hemodynamically unstable, warranting prompt imaging for diagnosis and treatment with arterial embolization, thus eliminating need of surgical intervention. url: https://www.ncbi.nlm.nih.gov/pubmed/32655742/ doi: 10.14740/jocmr4256 id: cord-269051-nl0jfqxt author: Patel, Krish title: Use of the IL‐6R Antagonist Tocilizumab in Hospitalized COVID‐19 Patients date: 2020-08-03 words: 1922.0 sentences: 108.0 pages: flesch: 55.0 cache: ./cache/cord-269051-nl0jfqxt.txt txt: ./txt/cord-269051-nl0jfqxt.txt summary: Baseline patient demographic and clinical characteristics including severity of COVID-19 illness using the Chinese CDC definition were recorded up to 10 days prior to anti-cytokine therapy. Survival and clinical outcomes were assessed for 42 tocilizumab-treated patients and 41 matched controls for whom at least 7 days of follow-up data were available or who had been discharged or died before 7 days following administration of tocilizumab or the corresponding time for the matched controls. The median time from hospitalization to receipt of tocilizumab therapy was 4 days (IQR, 4) and similar between severely and critically ill patients. At last follow-up 15 (71.4%) severely ill patients have been discharged, 4 (19.0%) died, with 2 (9.5%) remaining hospitalized ( Figure 1G ). In this retrospective cohort study, we report on use of tocilizumab in the treatment of severely and critically ill hospitalized COVID-19 patients. abstract: Severely ill COVID‐19 patients have a high risk of admission to the intensive‐care unit (ICU) and requirement for mechanical ventilation (MV), with in‐hospital mortality reported as 18‐79% globally.(1‐4). Among ICU patients in the United States (US), centers have reported 50% mortality.(5,6) Tocilizumab, an IL‐6 receptor (IL‐6R) antagonist, is FDA approved for the management of CAR T‐cell related Cytokine Release Syndrome (CRS) and may have utility in treatment of some COVID‐19 patients. We describe the clinical characteristics and initial outcomes of a cohort of patients treated with tocilizumab at the Swedish Medical Center in Seattle, Washington. url: https://www.ncbi.nlm.nih.gov/pubmed/32745348/ doi: 10.1111/joim.13163 id: cord-333142-ek7hct52 author: Patel, Shivani A. title: The Integrated Tracking, Referral, and Electronic Decision Support, and Care Coordination (I-TREC) program: scalable strategies for the management of hypertension and diabetes within the government healthcare system of India date: 2020-11-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Hypertension and diabetes are among the most common and deadly chronic conditions globally. In India, most adults with these conditions remain undiagnosed, untreated, or poorly treated and uncontrolled. Innovative and scalable approaches to deliver proven-effective strategies for medical and lifestyle management of these conditions are needed. METHODS: The overall goal of this implementation science study is to evaluate the Integrated Tracking, Referral, Electronic decision support, and Care coordination (I-TREC) program. I-TREC leverages information technology (IT) to manage hypertension and diabetes in adults aged ≥30 years across the hierarchy of Indian public healthcare facilities. The I-TREC program combines multiple evidence-based interventions: an electronic case record form (eCRF) to consolidate and track patient information and referrals across the publicly-funded healthcare system; an electronic clinical decision support system (CDSS) to assist clinicians to provide tailored guideline-based care to patients; a revised workflow to ensure coordinated care within and across facilities; and enhanced training for physicians and nurses regarding non-communicable disease (NCD) medical content and lifestyle management. The program will be implemented and evaluated in a predominantly rural district of Punjab, India. The evaluation will employ a quasi-experimental design with mixed methods data collection. Evaluation indicators assess changes in the continuum of care for hypertension and diabetes and are grounded in the Reach, Effectiveness, Adoption Implementation, and Maintenance (RE-AIM) framework. Data will be triangulated from multiple sources, including community surveys, health facility assessments, stakeholder interviews, and patient-level data from the I-TREC program’s electronic database. DISCUSSION: I-TREC consolidates previously proven strategies for improved management of hypertension and diabetes at single-levels of the healthcare system into a scalable model for coordinated care delivery across all levels of the healthcare system hierarchy. Findings have the potential to inform best practices to ultimately deliver quality public-sector hypertension and diabetes care across India. TRIAL REGISTRATION: The study is registered with Clinical Trials Registry of India (registration number CTRI/2020/01/022723). The study was registered prior to the launch of the intervention on 13 January 2020. The current version of protocol is version 2 dated 6 June 2018. url: https://www.ncbi.nlm.nih.gov/pubmed/33168004/ doi: 10.1186/s12913-020-05851-w id: cord-291686-kgewmqg5 author: Patel, Surendra title: Prioritizing cardiovascular surgical care in COVID‐19 pandemic: Shall we operate or defer? date: 2020-07-15 words: 1620.0 sentences: 98.0 pages: flesch: 46.0 cache: ./cache/cord-291686-kgewmqg5.txt txt: ./txt/cord-291686-kgewmqg5.txt summary: Moreover there is lack of sufficient data regarding impact of COVID-19 on post operative outcomes in patients who were infected with novel coronavirus and underwent cardiac and thoracic procedures. Peng et al 3 reported that patient who underwent thoracic surgery at the time of pandemic and later found to be affected with the novel coronavirus had greater than anticipated incidence of severe illness as well as case fatality rate, thus emphasizing the importance of correct triage and prioritizing cases to be considered for cardiac and thoracic surgery. 14 American college of surgeons has defined triage guidelines for vascular surgery patients, 8 and have provided guidelines regarding whether to postpone or not, vascular surgical procedures including, ascending aortic aneurysm, peripheral aneurysms, aortic dissection, mesenteric ischemia, peripheral vascular disease, trauma, venous thromboembolism, and amputation of limbs (Table 2) . abstract: BACKGROUND: The coronavirus disease (COVID‐19) has affected a large population across the world. Patients with cardiovascular disease have increased morbidity and mortality due to coronavirus disease. The burden over the health care system has to be reduced in this global pandemic to provide optimal care of patients with COVID‐19, as well not compromising those who are in need of emergent cardiovascular care. METHODS: There is a very limited data published defining which cardiovascular procedures are to be performed or to be deferred in the COVID‐19 pandemic. In this article, we have reviewed a few published guidelines regarding cardiovascular surgery in COVID‐19 pandemics. CONCLUSION: After reviewing a few available guidelines regarding cardiovascular surgery in COVID‐19, we conclude to perform only those surgeries which cannot be deferred to a certain period of time, to reduce the burden of the health care system of the country, provide optimal care to patients with COVID‐19, and to protect health care workers and cardiovascular patients from COVID‐19. url: https://www.ncbi.nlm.nih.gov/pubmed/32668048/ doi: 10.1111/jocs.14864 id: cord-312313-guphuppy author: Patel, Zara M title: Letter: Precautions for Endoscopic Transnasal Skull Base Surgery During the COVID-19 Pandemic date: 2020-04-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/neuros/nyaa125 doi: 10.1093/neuros/nyaa125 id: cord-017799-2nvrakbs author: Patel, Zara M. title: Acute Bacterial Rhinosinusitis date: 2018-05-04 words: 4391.0 sentences: 220.0 pages: flesch: 41.0 cache: ./cache/cord-017799-2nvrakbs.txt txt: ./txt/cord-017799-2nvrakbs.txt summary: Acute bacterial rhinosinusitis most commonly occurs as a complication of viral infection, complicating 0.5-2.0% of cases of the common cold [10] , However, other factors may also predispose to ABRS, such as allergy, immune dysfunction, impaired ciliary function, anatomic narrowing of the sinuses, or poor dentition [11] . Only for suspected complication involving orbit or central nervous system Similar recommendations for adults Initial therapy of ABRS Antibiotics for worsening course or severe onset ("2" or "3" above), but antibiotics or watchful waiting (for up to 3 days) for "persistent illness" ("1" above) abstract: Acute bacterial rhinosinusitis (ABRS) is a highly prevalent disease associated with significant direct and indirect costs. It is paramount that a practitioner can distinguish between acute viral rhinosinusitis and ABRS to avoid unnecessary antibiotic usage. It is also important to understand that establishing a diagnosis of ABRS does not necessitate the prescribing of antibiotics, unless the ABRS patient presents with severe or worsening symptoms or an ABRS complication. Complications include extension of infection to the orbit and central nervous system. Injudicious use of antibiotics imparts societal costs in terms of financial expense as well as contributing to higher levels of bacterial resistance. This chapter reviews the epidemiology, clinical features, diagnosis, and treatment of ABRS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122468/ doi: 10.1007/978-3-319-74835-1_11 id: cord-310661-hrvuhkq9 author: Patell, Rushad title: Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID‐19 date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus Disease‐2019 (COVID‐19) is a recognized prothrombotic state. Patients hospitalized with active cancer are predisposed to thrombosis but whether active cancer further amplifies thrombotic risk with COVID‐19 is not known. OBJECTIVES: To evaluate cumulative incidences of thrombotic and hemorrhagic events in hospitalized COVID‐19 patients with and without active cancer at 28 days. METHODS: A retrospective cohort analyses of consecutive adults hospitalized with COVID‐19 was performed. Active cancer required cancer‐directed therapy within last 6 months. The cumulative incidences of thrombosis or hemorrhage were estimated considering death as a competing risk. RESULTS: Patients without cancer (n=353) and active cancer (n=45) were comparable in terms of age, sex, antibiotics administered, length of hospitalization, and critical care. The most common malignancies were lymphoid (17.8%), gastrointestinal (15.6%), lung (13.3%), and genitourinary (13.3%). At day 28, the cumulative incidence of thrombotic events was 18.2% (95% CI, 10.2% to 27.9%) in non‐cancer cohort and 14.2% (95% CI, 4.7% to 28.7%) in the cancer cohort. The cumulative incidence of major and fatal bleeding at day 28 was 20.8% (95% CI, 12.1 to 31.0%) in the non‐cancer group and 19.5% (95% CI, 5.5% to 39.8%) in the cancer cohort. Three patients experienced fatal bleeds, all of whom were in the non‐cancer cohort. Survival was significantly shorter in the group with active cancer (P=0.038). CONCLUSIONS: We observed a similarly high incidence of thrombosis and bleeding among patients admitted with COVID‐19 with or without active cancer. url: https://www.ncbi.nlm.nih.gov/pubmed/32692862/ doi: 10.1111/jth.15018 id: cord-339705-x8l3zgfd author: Patil, Vijaykumar title: An association between fingerprint patterns with blood group and lifestyle based diseases: a review date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In the current era of the digital world, the hash of any digital means considered as a footprint or fingerprint of any digital term but from the ancient era, human fingerprint considered as the most trustworthy criteria for identification and it also cannot be changed with time even up to the death of an individual. In the court of law, fingerprint-proof is undeniably the most dependable and acceptable evidence to date. Fingerprint designs are exclusive in each human and the chance of two individuals having identical fingerprints is an exceptional case about one in sixty-four thousand million also the fingerprint minutiae patterns of the undistinguishable twins are different, and the ridge pattern of each fingertip remain unchanged from birth to till death. Fingerprints can be divided into basic four categories i.e. Loop, whorl, arch, and composites, nevertheless, there are more than 100 interleaved ridge and valleys physiognomies, called Galton’s details, in a single rolled fingerprint. Due to the immense potential of fingerprints as an effective method of identification, the present research paper tries to investigate the problem of blood group identification and analysis of diseases those arises with aging like hypertension, type 2-diabetes and arthritis from a fingerprint by analyzing their patterns correlation with blood group and age of an individual. The work has been driven by studies of anthropometry, biometric trademark, and pattern recognition proposing that it is possible to predict blood group using fingerprint map reading. Dermatoglyphics as a diagnostic aid used from ancient eras and now it is well established in number of diseases which have strong hereditary basis and is employed as a method for screening for abnormal anomalies. Apart from its use in predicting the diagnosis of disease; dermatoglyphics is also used in forensic medicine in individual identification, physical anthropology, human genetics and medicine. However, the Machine and Deep Learning techniques, if used for fingerprint minutiae patterns to be trained by Neural Network for blood group prediction and classification of common clinical diseases arises with aging based on lifestyle would be an unusual research work. url: https://doi.org/10.1007/s10462-020-09891-w doi: 10.1007/s10462-020-09891-w id: cord-274542-fpzk5k79 author: Patti, Giuseppe title: Questions and Answers on Practical Thrombotic Issues in SARS-CoV-2 Infection: A Guidance Document from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology date: 2020-11-03 words: 5628.0 sentences: 239.0 pages: flesch: 32.0 cache: ./cache/cord-274542-fpzk5k79.txt txt: ./txt/cord-274542-fpzk5k79.txt summary: UFH should be limited to patients with CrCl < 30 mL/min An invasive "catheter"-based therapy for PE is indicated in selected cases with contraindication to anticoagulant drugs, recurrent events despite adequate anticoagulation, or when systemic fibrinolysis cannot be performed For the risk stratification of patients with VTE, monitoring of the following parameters is useful: troponin, BNP, D-dimer, blood cell count, fibrinogen, prothrombin time, activated partial thromboplastin time, and degradation products of fibrin After the initial approach, DOACs may represent an option for in-hospital treatment of a VTE episode in patients with clinical stability and decreasing inflammation After a VTE episode, DOACs should represent the therapy of choice at discharge The use of imaging techniques in diagnosing a VTE episode is complex, because of the risk of viral transmission to other patients and to healthcare workers, and must be regulated by specific in-hospital protocols aimed at limiting such risk. abstract: In patients with coronavirus disease 2019 (COVID-19), the prevalence of pre-existing cardiovascular diseases is elevated. Moreover, various features, also including pro-thrombotic status, further predispose these patients to increased risk of ischemic cardiovascular events. Thus, the identification of optimal antithrombotic strategies in terms of the risk–benefit ratio and outcome improvement in this setting is crucial. However, debated issues on antithrombotic therapies in patients with COVID-19 are multiple and relevant. In this article, we provide ten questions and answers on risk stratification and antiplatelet/anticoagulant treatments in patients at risk of/with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection based on the scientific evidence gathered during the pandemic. url: https://doi.org/10.1007/s40256-020-00446-6 doi: 10.1007/s40256-020-00446-6 id: cord-313136-ab56mg6j author: Pavoni, Vittorio title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Critically ill patients with COVID-19 pneumonia suffered both high thrombotic and bleeding risk. The effect of SARS-CoV-2 on coagulation and fibrinolysis is not well known. We conducted a retrospective study of critically ill patients admitted to an intensive care unit (ICU) a cause of severe COVID-19 pneumonia and we evaluated coagulation function using rotational thromboelastometry (ROTEM) on day of admission (T0) and 5 (T5) and 10 (T10) days after admission to ICU. Coagulation standard parameters were also evaluated. Forty patients were enrolled into the study. The ICU and the hospital mortality were 10% and 12.5%, respectively. On ICU admission, prothrombin time was slightly reduced and it increased significantly at T10 (T0 = 65.1 ± 9.8 vs T10 = 85.7 ± 1.5, p = 0.002), while activated partial thromboplastin time and fibrinogen values were higher at T0 than T10 (32.2 ± 2.9 vs 27.2 ± 2.1, p = 0.017 and 895.1 ± 110 vs 332.5 ± 50, p = 0.002, respectively); moreover, whole blood thromboelastometry profiles were consistent with hypercoagulability characterized by an acceleration of the propagation phase of blood clot formation [i.e., CFT below the lower limit in INTEM 16/40 patients (40%) and EXTEM 20/40 patients (50%)] and significant higher clot strength [MCF above the upper limit in INTEM 20/40 patients (50%), in EXTEM 28/40 patients (70%) and in FIBTEM 29/40 patients (72.5%)]; however, this hypercoagulable state persists in the first five days, but it decreases ten day after, without returning to normal values. No sign of secondary hyperfibrinolysis or sepsis induced coagulopathy (SIC) were found during the study period. In six patients (15%) a deep vein thrombosis and in 2 patients (5%) a thromboembolic event, were found; 12 patients (30%) had a catheter-related thrombosis. ROTEM analysis confirms that patients with severe COVID-19 pneumonia had a hypercoagulation state that persisted over time. url: https://doi.org/10.1007/s11239-020-02130-7 doi: 10.1007/s11239-020-02130-7 id: cord-006394-ucthbqvt author: Pawlik, Timothy M. title: Combined Resection and Radiofrequency Ablation for Advanced Hepatic Malignancies: Results in 172 Patients date: 2003 words: 6124.0 sentences: 313.0 pages: flesch: 45.0 cache: ./cache/cord-006394-ucthbqvt.txt txt: ./txt/cord-006394-ucthbqvt.txt summary: Conclusions: Resection combined with RFA provides a surgical option to a group of patients with liver metastases who traditionally are unresectable, and may increase long-term survival. Surgical resection of primary and metastatic liver tumors is considered to be the optimal treatment modality with a curative effect, offering a 5-year survival rate between 20% and 35%. For purposes of this study, the following were collected for all patients: patient age and sex; tumor histology, number, location, and size; type of surgical resection; operative details; disease status; follow-up date; death date; and complication data. Those patients who had more than 10 tumors treated with combined hepatic resection and RFA were significantly more likely to have a shorter time to recurrence than those with less disease (HR ϭ 1.63, CI ϭ 1.12-2.36, P ϭ .009). Our group of 172 patients treated with combined hepatic resection and RFA of malignant liver tumors is the largest series reported to date. abstract: Background: Resection combined with radiofrequency ablation (RFA) is a novel approach in patients who are otherwise unresectable. The objective of this study was to investigate the safety and efficacy of hepatic resection combined with RFA. Methods: Patients with multifocal hepatic malignancies were treated with surgical resection combined with RFA. All patients were followed prospectively to assess complications, treatment response, and recurrence. Results: Seven hundred thirty seven tumors in 172 patients were treated (124 with colorectal metastases; 48 with noncolorectal metastases). RFA was used to treat 350 tumors. Combined modality treatment was well tolerated with low operative times and minimal blood loss. The postoperative complication rate was 19.8% with a mortality rate of 2.3%. At a median follow-up of 21.3 months, tumors had recurred in 98 patients (56.9%). Failure at the RFA site was uncommon (2.3%). A combined total number of tumors treated with resection and RFA >10 was associated with a faster time to recurrence (P = .02). The median actuarial survival time was 45.5 months. Patients with noncolorectal metastases and those with less operative blood loss had an improved survival (P = .03 and P = .04, respectively), whereas radiofrequency ablating a lesion >3 cm adversely impacted survival (HR = 1.85, P = .04). Conclusions: Resection combined with RFA provides a surgical option to a group of patients with liver metastases who traditionally are unresectable, and may increase long-term survival. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101740/ doi: 10.1245/aso.2003.03.026 id: cord-158252-l43ztxsl author: Pawlowski, Colin title: Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures date: 2020-05-21 words: 6126.0 sentences: 221.0 pages: flesch: 35.0 cache: ./cache/cord-158252-l43ztxsl.txt txt: ./txt/cord-158252-l43ztxsl.txt summary: We found that compared to COVIDneg at the time of clinical presentation and diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and similarly low platelet counts, with approximately 25% of patients in both cohorts showing outright thrombocytopenia. To this end, we instituted a holistic data science platform across an academic health care system that enables machine intelligence to augment the curation of phenotypes and outcomes from 15.2 million EHR clinical notes and associated 3 million lab tests from 1,192 COVID-19positive (COVIDpos) and 47,344 confirmed COVID-19-negative (COVIDneg) patients over a retrospectively defined 2-month observation period straddling the date of the PCR test (see Methods). Conversely, platelet counts were lower in the COVIDpos cohort at the time of clinical presentation but tended to increase over the subsequent 10 days to levels significantly higher than those in COVIDneg patients (Cohen''s D = 0.361, BH-adjusted Mann-Whitney p-value = 0.008, Table 2, Figure 2B ). abstract: Temporal inference from laboratory testing results and their triangulation with clinical outcomes as described in the associated unstructured text from the providers notes in the Electronic Health Record (EHR) is integral to advancing precision medicine. Here, we studied 181 COVIDpos and 7,775 COVIDneg patients subjected to 1.3 million laboratory tests across 194 assays during a two-month observation period centered around their SARS-CoV-2 PCR testing dates. We found that compared to COVIDneg at the time of clinical presentation and diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and similarly low platelet counts, with approximately 25% of patients in both cohorts showing outright thrombocytopenia. However, these measures show opposite longitudinal trends as the infection evolves, with declining fibrinogen and increasing platelet counts to levels that are lower and higher compared to the COVIDneg cohort, respectively. Our EHR augmented curation efforts suggest a minority of patients develop thromboembolic events after the PCR testing date, including rare cases with disseminated intravascular coagulopathy (DIC), with most patients lacking the platelet reductions typically observed in consumptive coagulopathies. These temporal trends present, for the first time, fine-grained resolution of COVID-19 associated coagulopathy (CAC), via a digital framework that synthesizes longitudinal lab measurements with structured medication data and neural network-powered extraction of outcomes from the unstructured EHR. This study demonstrates how a precision medicine platform can help contextualize each patients specific coagulation profile over time, towards the goal of informing better personalization of thromboprophylaxis regimen. url: https://arxiv.org/pdf/2005.10938v1.pdf doi: nan id: cord-006595-brpngt14 author: Pecchi, A. title: Radiologic imaging of the transplanted bowel date: 2005-03-04 words: 6147.0 sentences: 257.0 pages: flesch: 37.0 cache: ./cache/cord-006595-brpngt14.txt txt: ./txt/cord-006595-brpngt14.txt summary: After sampling a loop easily accessible sonographically, axial and longitudinal US were views were scanned to evaluate the morphology, thickness, and echo structural features of the intestinal loops and color Doppler views of the superior mesenteric artery and wall arteriole of the sampled loop CT was performed with a multidetector scanner (General Electric Medical Systems) 2 to 4 weeks after surgery to evaluate the anatomy of the transplanted organs and arterial and venous anastomoses, complications previously identified with other methods or suspected, and periodically in the follow-up of patients who underwent transplantation due to Gardner syndrome. Traditional radiologic evaluation of the gastrointestinal tract with radiopaque contrast agent allowed anatomic and morphologic examinations of the graft, proximal and distal anastomoses, and tone and motility of transplanted loops in all patients (Fig. 1 ). abstract: BACKGROUND: The radiologic evaluation of the transplanted bowel is largely unknown and rather complex because it involves several techniques that depend on indications and times that have not been fully defined. METHODS: From December 2000 to November 2002 in the Section of Radiology I of the University of Modena and Reggio Emilia (Modena, Italy), 11 patients with transplanted bowel were studied with different methods: traditional radiologic evaluation with contrast agent (all patients), evaluation of transit time with radiopaque markers (five patients), ultrasonographic (US) evaluation of the intestinal wall and Doppler US of the vascular axes (five patients), computed tomographic (CT) evaluation (all patients), and magnetic resonance (MR) evaluation of the bowel and the vascular axes (five patients). Traditional contrast examination enabled evaluation of the gastroesophageal transit and cardia functionality; anatomy and integrity of the anastomoses (proximal and distal); time of gastric emptying; morphology, tone, and kinesis of the transplanted small bowel loops and time of global transit. The study of transit with radiopaque markers was carried out in five patients to define the time of transit through the entire transplanted bowel, confirm recovery of intestinal motility, and identify possible abnormalities. The US examination was carried out in five patients to evaluate the morphology, thickness, and echo structural features of the intestinal loops. Color Doppler was performed to visualize the superior mesenteric artery and a wall arteriole of the sampled loop. CT examination was performed 2 to 4 weeks after surgery to evaluate the anatomy of the transplanted organs, arterial and venous anastomoses in case of complications identified with other methods or suspected, and periodically in the follow-up of patients who underwent transplantation due to Gardner syndrome. The protocol for MR evaluation of the bowel included coronal single-shot fast spin-echo T2-weighted sequences, axial and/or sagittal single-shot fast spin-echo T2-weighted sequences, coronal fast multiplanar spoiled gradient-echo (FMP- SPGR) sequences, coronal FMPSPGR sequences with and without administration of intravenous paramagnetic contrast agent, and axial or sagittal FMPSPGR fat-saturated sequences performed after dynamic gadolinium administration. RESULTS AND CONCLUSION: The study of transit with radiopaque markers was useful in patients with chronic intestinal pseudo-obstruction because it identified recovery and normalization of motility. Traditional contrast examination of the gastrointestinal tract continues to play an important role in transplanted patients because it is a simple examination that allows evaluation of the graft anatomy and recovery of motility of the residual native bowel and the transplanted loops. Moreover, it plays a crucial role in early detection of major postoperative complications such as intestinal obstruction, perforation, fistulas, and anastomotic complications (stenosis and dehiscence). CT examination is crucial for the detection of fluid collections, abscesses, and fistulas because it can serve as a guide of drainage and during follow-up of patients with Gardner syndrome can be used to investigate all possible sites in which desmoids might arise in addition to their relation to the graft. Because patients with transplanted bowel are generally rather a young population of reproductive age and because of technologic advances, MR may represent an effective method that does not use ionizing radiation and can therefore substitute for traditional radiologic evaluation. US represents a quick examination technique that is easily available and well tolerated by patients, and it has a role to play in the follow-up of transplanted patients and in the identification of major postoperative complications. However, its role in monitoring possible rejection remains to be defined with studies on wider and more representative samples. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102087/ doi: 10.1007/s00261-004-0288-y id: cord-350232-zml4o93t author: Peck, Richard W title: A Real‐World Evidence Framework for Optimising Dosing in All Patients with COVID‐19 date: 2020-05-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The SARS‐CoV‐2 pandemic and associated COVID‐19 disease are straining healthcare systems around the world with large numbers of patients becoming ill in a very short period of time, overwhelming healthcare systems in many countries. Several drugs are being repurposed into clinical trials in COVID‐19 patients, ranging from drugs already well established in other diseases, such as chloroquine/hydroxychloroquine, lopinavir+ ritonavir, azithromycin and tocilizumab/sarilumab, to those such as remdesivir still in development for their initial indication (1). The opportunities for clinical pharmacology to contribute to the development of new treatments have already been described by others in Clinical Pharmacology & Therapeutics (2). url: https://doi.org/10.1002/cpt.1922 doi: 10.1002/cpt.1922 id: cord-266010-ectnfv5z author: Pediconi, Federica title: Breast imaging and cancer diagnosis during the COVID-19 pandemic: recommendations from the Italian College of Breast Radiologists by SIRM date: 2020-07-13 words: 2737.0 sentences: 120.0 pages: flesch: 39.0 cache: ./cache/cord-266010-ectnfv5z.txt txt: ./txt/cord-266010-ectnfv5z.txt summary: The Italian College of Breast Radiologists by the Italian Society of Medical Radiology (SIRM) provides recommendations for breast care provision and procedural prioritization during COVID-19 pandemic, being aware that medical decisions must be currently taken balancing patient''s individual and community safety: (1) patients having a scheduled or to-be-scheduled appointment for in-depth diagnostic breast imaging or needle biopsy should confirm the appointment or obtain a new one; (2) patients who have suspicious symptoms of breast cancer (in particular: new onset palpable nodule; skin or nipple retraction; orange peel skin; unilateral secretion from the nipple) should request non-deferrable tests at radiology services; (3) asymptomatic women performing annual mammographic follow-up after breast cancer treatment should preferably schedule the appointment within 1 year and 3 months from the previous check, compatibly with the local organizational conditions; (4) asymptomatic women who have not responded to the invitation for screening mammography after the onset of the pandemic or have been informed of the suspension of the screening activity should schedule the check preferably within 3 months from the date of the not performed check, compatibly with local organizational conditions. abstract: The Italian College of Breast Radiologists by the Italian Society of Medical Radiology (SIRM) provides recommendations for breast care provision and procedural prioritization during COVID-19 pandemic, being aware that medical decisions must be currently taken balancing patient’s individual and community safety: (1) patients having a scheduled or to-be-scheduled appointment for in-depth diagnostic breast imaging or needle biopsy should confirm the appointment or obtain a new one; (2) patients who have suspicious symptoms of breast cancer (in particular: new onset palpable nodule; skin or nipple retraction; orange peel skin; unilateral secretion from the nipple) should request non-deferrable tests at radiology services; (3) asymptomatic women performing annual mammographic follow-up after breast cancer treatment should preferably schedule the appointment within 1 year and 3 months from the previous check, compatibly with the local organizational conditions; (4) asymptomatic women who have not responded to the invitation for screening mammography after the onset of the pandemic or have been informed of the suspension of the screening activity should schedule the check preferably within 3 months from the date of the not performed check, compatibly with local organizational conditions. The Italian College of Breast Radiologists by SIRM recommends precautions to protect both patients and healthcare workers (radiologists, radiographers, nurses, and reception staff) from infection or disease spread on the occasion of breast imaging procedures, particularly mammography, breast ultrasound, breast magnetic resonance imaging, and breast intervention procedures. url: https://doi.org/10.1007/s11547-020-01254-3 doi: 10.1007/s11547-020-01254-3 id: cord-257274-fzyamd7v author: Peiro-Garcia, Alejandro title: How the COVID-19 pandemic is affecting paediatric orthopaedics practice: a preliminary report date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Since the state of alarm was decreed in Spain on 14 March 2020, the coronavirus disease 2019 (COVID-19) pandemic has had an extraordinary impact in paediatric hospitals. This study shows the effect of the pandemic on our practice in paediatric orthopaedics in a referral third level paediatric hospital. METHODS: We performed a single-centre retrospective review of the official census from a third level paediatric hospital from 14 March to 14 April for the years 2018, 2019 and 2020. RESULTS: The patients seen in our clinic during this period in 2020 decreased in by 82% (p < 0.001) compared with 2018 and 2019, however, the number of telemedicine consultations increased by 90.21% (p < 0.001). The total number of patients attending the clinic (including onsite and virtual) was reduced by 54.25% (p < 0.001). The total surgeries performed plummeted by 81% in this period in 2020 (p < 0.001) due to a reduction in elective cases of 94.6% (p < 0.001). No significant decrease was found in the number of urgent surgical cases per day in 2020 (p = 0.34). Finally, the number of orthopaedic patients admitted to our emergency department dropped by 78.6% during the state of alarm (p < 0.001). CONCLUSION: According to our results, the pandemic has significantly affected our daily practice by decreasing elective surgeries and onsite clinics, but other activities have increased. As we have implemented telemedicine and new technologies to adapt to this setback, we should take advantage of the situation to change our practice in the future to better allocate our health resources and to anticipate outbreaks. Published without peer review. LEVEL OF EVIDENCE: IV url: https://www.ncbi.nlm.nih.gov/pubmed/32582381/ doi: 10.1302/1863-2548.14.200099 id: cord-306016-2gudro8v author: Pelt, Christopher E. title: The Rapid Response to the COVID-19 Pandemic by the Arthroplasty Divisions at Two Academic Referral Centers date: 2020-04-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has created widespread changes across all of healthcare. The impacts on the delivery of orthopaedic services has been challenged as a result. In order to ensure and provide for adequate health care resources in terms of hospital capacity, personnel and personal protective equipment (PPE), service lines such as adult reconstruction and lower limb arthroplasty have stopped or substantially limited elective surgeries and have been forced to re-engineer care processes for a high-volume of patients. Herein, we summarize the similar approaches by two arthroplasty divisions in high volume academic referral centers in 1) the cessation of elective surgeries, 2) workforce restructuring, 3) phased delivery of outpatient and inpatient care, and 4) educational restructuring. url: https://api.elsevier.com/content/article/pii/S0883540320303843 doi: 10.1016/j.arth.2020.04.030 id: cord-015946-biu5zxd1 author: Peng, Daizhi title: Research Advances in Biomarker for Sepsis date: 2016-11-16 words: 5100.0 sentences: 242.0 pages: flesch: 40.0 cache: ./cache/cord-015946-biu5zxd1.txt txt: ./txt/cord-015946-biu5zxd1.txt summary: Most commonly proposed sepsis and infection biomarkers including C-reactive protein (CRP), procalcitonin (PCT) [5, 6] , cytokines (TNF-α, IL-1, IL-6, IL-10, osteopontin) [7, 8] , chemokines [macrophage migration inhibitory factor (MIF), high-mobility-group box 1 (HMGB1)] [9, 10] , soluble receptor [soluble triggering receptor expressed on myeloid cells 1 (sTREM-1), soluble urokinase-type plasminogen activator receptor (suPAR)] [11, 12] etc. When it comes to sepsis, by using genome-wide miRNA profiling with microarray in peripheral blood leukocytes and quantitative RT-PCR, Vasilescu [71] found that miR-150 levels were significantly reduced in both leukocytes and plasma of sepsis patients and had a negative correlation with the level of disease severity measured by the Sequential Organ Failure Assessment (SOFA) score, which made it a biomarker of early sepsis. As they were significantly correlated with disease severity, classical markers of inflammation and bacterial infection, as well as organ failure, high miR-133a levels were considered as independent biomarkers for unfavorable prognosis of critically ill patients. abstract: Sepsis is one of the most common causes of death in severely injured patients worldwide. The early detection of sepsis still has to be solved in clinical practice. The delayed diagnosis often contributes to inappropriate antimicrobial treatment and subsequent high mortality. Sepsis biomarkers are produced during the host response to infection. Traditional biomarkers are polypeptides and/or proteins derived from this response. Omics-based biomarkers are screening out from all kinds of molecules of host response while high-throughout omics technologies are emerging. This review describes traditional and potential omics-based sepsis biomarkers from currently available literatures. The combination of these biomarkers would refine the identification of sepsis for further clinical and experimental sepsis studies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120075/ doi: 10.1007/978-981-10-2425-2_15 id: cord-030369-4dn02a35 author: Peng, Liang title: Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure) date: 2019-05-21 words: 35858.0 sentences: 1603.0 pages: flesch: 38.0 cache: ./cache/cord-030369-4dn02a35.txt txt: ./txt/cord-030369-4dn02a35.txt summary: Once pulmonary infection is present, the disease condition will likely deteriorate, directly causing death; (3) a majority of infections are nosocomial infection, and pathogens are usually resistant to common antibiotics, making therapy challenging; (4) the pathogens causing infection are diverse but mainly Gram-negative bacteria, although the incidence of Gram-positive and fungal infections is increasing; (5) infection is closely related to the prognosis for liver failure patients. Although their clinical manifestation differ significantly, the "coexistence of acute and chronic failures" is shared by failures of all those organs; (2) CLF classification has been generally recognized at home and abroad, and the necessity of classification are further proved by the difference between CLF and the other three types; (3) CLF cases are relatively large in proportion (nearly 30%), which is still increasing (since the proportion of ALF/SALF are lowering); (4) Complications of CLF are common and are found in various forms, with bad prognosis; (5) In CLF patients with correlation to HBV, virus replication are commonly found, which is closely related to decompensation. abstract: This chapter describes the clinical symptoms and signs of AECHB and HBV ACLF, classification, grading of HBV ACLF and their features, diagnostic principles and standards in liver pathology, biochemistry, and virology of HBV ACLF. 1. Liver failure is defined as serious damage to the liver cause by a variety of etiologies, leading to liver function disorder or even decompensation, and clinical syndromes with coagulopathy, jaundice, hepatic encephalopathy, and ascites. 2. Severe hepatitis B can be indicated pathologically by apparent hepatocellular necrosis, including extensive multifocal, confluent, bridging, sub-massive or massive necrosis. 3. Laboratory tests during the course of severe exacerbation of chronic hepatitis B can reflect pathological changes and liver function in a timely manner, providing objective and informative reference data for evaluation of disease severity and treatment efficacy. Among the most important laboratory tests are those for prothrombin activity, international normalized ratio, and increases in total bilirubin concentration. 4. Severe hepatitis B is associated with interactions between the virus and host factors. Detection of HBV DNA, HBV genotype, quasispecies and HBV mutation can provide important theoretical bases for the prevention, control or mitigation of the progress of severe hepatitis B. 5. Noninvasive imaging modalities can be used to visualize the entire liver and parts of it. Measuring liver volume to evaluate liver size and liver reserve capacity is regarded as important in diagnosis, surgical approach and prognostic evaluation of patients with severe exacerbation of chronic hepatitis B and liver failure. 6. Model for End-Stage Liver Disease (MELD) is the first quantitative method developed to assess whether a patient with liver failure requires a liver transplant. The predictive value of the MELD model has been improved by the MELD-Na, iMELD, and MESO models. Several other valuable prognostic models have been developed. For example, for patients with HBV-ACLF, the established TPPM scoring system was found to be more predictive than MELD score. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418529/ doi: 10.1007/978-94-024-1603-9_1 id: cord-296113-syi2fwuo author: Peng, Mian title: Two mechanically ventilated cases of COVID-19 successfully managed with a sequential ventilation weaning protocol: Two case reports date: 2020-08-06 words: 2618.0 sentences: 148.0 pages: flesch: 51.0 cache: ./cache/cord-296113-syi2fwuo.txt txt: ./txt/cord-296113-syi2fwuo.txt summary: BACKGROUND: Patients with critical coronavirus disease 2019 (COVID-19), characterized by respiratory failure requiring mechanical ventilation (MV), are at high risk of mortality. When their condition did not improve after 2 h of NIV, each patient was advanced to MV [tidal volume (Vt), 6 mL/kg ideal body weight (IBW); 8-10 cmH(2)O of positive end-expiratory pressure; respiratory rate, 20 breaths/min; and 40%-80% FiO(2)] with prone positioning for 12 h/day for the first 5 d of MV. CONCLUSION: A MV protocol attentive to intubation/extubation timing, prone positioning early in MV, infection control, and sequential withdrawal of respiratory support, may be an effective regimen for patients with critical COVID-19. In accordance with this recommendation, we summarize our weaning procedure and associated experience with two critical COVID-19 patients, including intubation timing, use of the prone position, infection control, and sedation titration. abstract: BACKGROUND: Patients with critical coronavirus disease 2019 (COVID-19), characterized by respiratory failure requiring mechanical ventilation (MV), are at high risk of mortality. An effective and practical MV weaning protocol is needed for these fragile cases. CASE SUMMARY: Here, we present two critical COVID-19 patients who presented with fever, cough and fatigue. COVID-19 diagnosis was confirmed based on blood cell counts, chest computed tomography (CT) imaging, and nuclei acid test results. To address the patients’ respiratory failure, they first received noninvasive ventilation (NIV). When their condition did not improve after 2 h of NIV, each patient was advanced to MV [tidal volume (Vt), 6 mL/kg ideal body weight (IBW); 8-10 cmH(2)O of positive end-expiratory pressure; respiratory rate, 20 breaths/min; and 40%-80% FiO(2)] with prone positioning for 12 h/day for the first 5 d of MV. Extensive infection control measures were conducted to minimize morbidity, and pharmacotherapy consisting of an antiviral, immune-enhancer, and thrombosis prophylactic was administered in both cases. Upon resolution of lung changes evidenced by CT, the patients were sequentially weaned using a weaning screening test, spontaneous breathing test, and airbag leak test. After withdrawal of MV, the patients were transitioned through NIV and high-flow nasal cannula oxygen support. Both patients recovered well. CONCLUSION: A MV protocol attentive to intubation/extubation timing, prone positioning early in MV, infection control, and sequential withdrawal of respiratory support, may be an effective regimen for patients with critical COVID-19. url: https://doi.org/10.12998/wjcc.v8.i15.3305 doi: 10.12998/wjcc.v8.i15.3305 id: cord-347414-t88654wo author: Peng, Mian title: Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We report the clinical and laboratory findings and successful management of seven patients with critical coronavirus disease 2019 (COVID-19) requiring mechanical ventilation (MV). The patients were diagnosed based on epidemiological history, clinical manifestations, and nucleic acid testing. Upon diagnosis with COVID-19 of critical severity, the patients were admitted to the intensive care unit, where they received early noninvasive–invasive sequential ventilation, early prone positioning, and bundle pharmacotherapy regimen, which consists of antiviral, anti-inflammation, immune-enhancing, and complication-prophylaxis medicines. The patients presented fever (n = 7, 100%), dry cough (n = 3, 42.9%), weakness (n = 2, 28.6%), chest tightness (n = 1, 14.3%), and/or muscle pain (n = 1, 14.3%). All patients had normal or lower than normal white blood cell count/lymphocyte count, and chest computed tomography scans showed bilateral patchy shadows or ground glass opacity in the lungs. Nucleic acid testing confirmed COVID-19 in all seven patients. The median MV duration and intensive care unit stay were 9.9 days (interquartile range, 6.5–14.6 days; range, 5–17 days) and 12.9 days (interquartile range, 9.7–17.6 days; range, 7–19 days), respectively. All seven patients were extubated, weaned off MV, transferred to the common ward, and discharged as of the writing of this report. Thus, we concluded that good outcomes for patients with critical COVID-19 can be achieved with early noninvasive–invasive sequential ventilation and bundle pharmacotherapy. url: https://www.ncbi.nlm.nih.gov/pubmed/32761492/ doi: 10.1007/s11684-020-0796-3 id: cord-312065-nqy7m38f author: Peng, Philip W. H. title: Infection control and anesthesia: Lessons learned from the Toronto SARS outbreak date: 2003 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To describe the outbreak of severe acute respiratory syndrome (SARS) in Toronto, its impact on anesthesia practice and the infection control guidelines adopted to manage patients in the operating room (OR) and to provide emergency intubation outside the OR. CLINICAL FEATURES: The SARS outbreak in Toronto was the result of a single index patient. The causative virus, SARS-CoV, is moderately contagious, and is spread by droplets and contact. The virus gains access to host through the mucosa of the respiratory tract and the eyes. It can affect both healthy and compromised patients. The use of several precautionary measures such as goggles, gloves, gowns and facemasks and the application of various infection control strategies designed to minimize the spread of the virus are discussed. CONCLUSION: In containing the spread of SARS, vigilance and strict infection control are important. This results in the rediscovery of standards of infection control measures in daily anesthesia practice. url: https://www.ncbi.nlm.nih.gov/pubmed/14656775/ doi: 10.1007/bf03018361 id: cord-315730-fzgxuak7 author: Penman, Sophie L. title: Safety perspectives on presently considered drugs for the treatment of COVID‐19 date: 2020-07-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Intense effort is underway to evaluate potential therapeutic agents for the treatment of COVID‐19. In order to respond quickly to the crisis, the repurposing of existing drugs is the primary pharmacological strategy. Despite the urgent clinical need for these therapies, it is imperative to consider potential safety issues. This is important due to the harm‐benefit ratios that may be encountered when treating COVID‐19, which can depend on the stage of the disease, when therapy is administered and underlying clinical factors in individual patients. Treatments are currently being trialled for a range of scenarios from prophylaxis (where benefit must greatly exceed risk) to severe life‐threatening disease (where a degree of potential risk may be tolerated if it is exceeded by the potential benefit). In this perspective, we have reviewed some of the most widely‐researched repurposed agents in order to identify potential safety considerations using existing information in the context of COVID‐19. url: https://www.ncbi.nlm.nih.gov/pubmed/32681537/ doi: 10.1111/bph.15204 id: cord-311847-2czqs84q author: Pennisi, Manuela title: SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms date: 2020-07-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Increasing evidence suggests that Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2) can also invade the central nervous system (CNS). However, findings available on its neurological manifestations and their pathogenic mechanisms have not yet been systematically addressed. A literature search on neurological complications reported in patients with COVID-19 until June 2020 produced a total of 23 studies. Overall, these papers report that patients may exhibit a wide range of neurological manifestations, including encephalopathy, encephalitis, seizures, cerebrovascular events, acute polyneuropathy, headache, hypogeusia, and hyposmia, as well as some non-specific symptoms. Whether these features can be an indirect and unspecific consequence of the pulmonary disease or a generalized inflammatory state on the CNS remains to be determined; also, they may rather reflect direct SARS-CoV-2-related neuronal damage. Hematogenous versus transsynaptic propagation, the role of the angiotensin II converting enzyme receptor-2, the spread across the blood-brain barrier, the impact of the hyperimmune response (the so-called “cytokine storm”), and the possibility of virus persistence within some CNS resident cells are still debated. The different levels and severity of neurotropism and neurovirulence in patients with COVID-19 might be explained by a combination of viral and host factors and by their interaction. url: https://www.ncbi.nlm.nih.gov/pubmed/32751841/ doi: 10.3390/ijms21155475 id: cord-252060-cotsu82v author: Pericleous, Stephanos title: Coronavirus Disease 2019 Pandemic: Potential Collateral Damage on Patients With Operable Pancreatic Cancer date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32604204/ doi: 10.1097/mpa.0000000000001594 id: cord-263191-osa3ylkl author: Pericàs, Juan M. title: Hospital at home for the management of COVID-19: preliminary experience with 63 patients date: 2020-09-29 words: 1729.0 sentences: 80.0 pages: flesch: 45.0 cache: ./cache/cord-263191-osa3ylkl.txt txt: ./txt/cord-263191-osa3ylkl.txt summary: We aimed to describe the characteristics and outcomes of patients with COVID-19 transferred from the hospital to a HaH unit during the peak of the first wave of the pandemic in Barcelona, Spain. (1) Caregiver available 24 h at the patients'' home; (2) home conditions allowing patient isolation from cohabitants; (3) early discharge from hospital ward: more than 6 days since the start of symptoms; no fever in the last 24 h; respiratory rate < 22 rpm and oxygen saturation > 95% with F i O2 < 0.35; C Reactive protein < 5 mg/dl or descending, normal LDH or descending, lymphocytes > 800 cells/mm 3 or ascending; no radiological progression of pneumonia; (4) admission from Emergency room: bilateral pneumonia in patient without high-risk factors (> 65 years old, hypertension, chronic obstructive pulmonary disease, cardiovascular disease, diabetes, cancer, and immunosuppression); respiratory infection without pneumonia, or unilobar pneumonia in patients with risk factors. abstract: Alternatives to conventional hospitalization are needed to increase health systems resilience in the face of COVID-19 pandemic. Herein, we describe the characteristics and outcomes of 63 patients admitted to a single HaH during the peak of COVID-19 in Barcelona. Our results suggest that HaH seems to be a safe and efficacious alternative to conventional hospitalization for accurately selected patients with COVID-19. url: https://doi.org/10.1007/s15010-020-01527-z doi: 10.1007/s15010-020-01527-z id: cord-253375-m3qjj7r4 author: Perini, Guilherme Fleury title: How to manage lymphoid malignancies during novel 2019 coronavirus (CoVid-19) outbreak: a Brazilian task force recommendation date: 2020-04-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel Coronavirus (CoVid-19) outbreak is now consider a world pandemic, affecting more than 300,000 people worldwide. Cancer patients are in risk for severe disease, including a higher risk of intensive care unit (ICU) admission, need for invasive ventilation or death. Management of patients with lymphoid malignancies can be challenging during the outbreak, due to need of multiple hospital visits and admissions, immunosuppression and need for chemotherapy, radiotherapy and stem cell transplantation. In this article, we will focus on the practical management of patients with lymphoid malignancies during the COVID-19 pandemic, focusing on minimizing the risk for patients. url: https://api.elsevier.com/content/article/pii/S253113792030033X doi: 10.1016/j.htct.2020.04.002 id: cord-329444-t8ixrdpq author: Persaud., Yudy K. title: Ten Rules for Implementation of a Telemedicine Program to Care for Patients with Asthma date: 2020-10-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33039648/ doi: 10.1016/j.jaip.2020.10.005 id: cord-326354-fhafg41x author: Pesavento, Raffaele title: The hazard of (sub)therapeutic doses of anticoagulants in non‐critically ill patients with Covid‐19: the Padua province experience date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: COVID‐19 is responsible for a worldwide pandemic, with a high rate of morbidity and mortality. The increasing evidence of an associated relevant pro‐thrombotic coagulopathy has resulted in an increasing use of antithrombotic doses higher than usual in COVID‐19 patients. Information on the benefit/risk ratio of this approach is still lacking. OBJECTIVE: to assess the incidence of relevant bleeding complications in association with the antithrombotic strategy, and its relationship with the amount of drug. METHODS: Consecutive COVID‐19 patients admitted between February and April 2020 were included in a retrospective analysis. Major bleedings (MB) and clinical relevant non‐major bleeding (CRNMB) were obtained from patient medical records and were adjudicated by an independent committee. RESULTS: Of the 324 patients who were recruited, 240 had been treated with prophylactic doses and 84 with higher doses of anticoagulants. The rate of the composite endpoint of MB or CRNMB was 6.9 per 100 person/months in patients who had been given prophylactic doses, and 26.4 per 100 persons/months in those who had been prescribed higher doses (HR 3.89; 95%CI, 1.90 to 7.97). The corresponding rates for overall mortality were 12.2 and 20.1 per 100 person/months, respectively. CONCLUSIONS: The rate of relevant bleeding events were high in patients treated with (sub)therapeutic doses of anticoagulants. In the latter group, overall mortality did not differ from that of patients treated with standard prophylactic doses and was even higher. Our result does not support a strategy of giving (sub)therapeutic doses of anticoagulants in non‐critically ill patients with COVID‐19. url: https://doi.org/10.1111/jth.15022 doi: 10.1111/jth.15022 id: cord-276856-88d3vzbs author: Petersen, Lonnie G. title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients date: 2020-06-18 words: 644.0 sentences: 46.0 pages: flesch: 53.0 cache: ./cache/cord-276856-88d3vzbs.txt txt: ./txt/cord-276856-88d3vzbs.txt summary: title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients With a potential COVID19-induced ventilator shortage, supporting multiple patients on a single ventilator seems a simple solution to maximize resources. Beyond cross-contamination and increased dead space, matching patients to ensure appropriate individual ventilation peak pressures (P peak ), tidal volumes (V tidal ), and positive endexpiratory pressures (PEEP) is a concern, especially given the dynamic clinical presentation of the COVID19 patients with complicated acute respiratory distress syndrome (ARDS). One-way valves on both inspiratory and expiratory limbs ensured unidirectional flow, which both reduces functional dead space and the risk of crosscontamination between patient A and B, and seemingly also facilitated stable ventilation of B as A deteriorated. Finally, each class of ventilators requires a specific set up; if the method is considered, use the calm before the patient surge to familiarize, and ameliorate the many risks associated with sharing a ventilator. A single ventilator for multiple simulated patients to meet disaster surge abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32552914/ doi: 10.1186/s13054-020-03041-y id: cord-351223-nnuoadh6 author: Pettit, Natasha N. title: Obesity is Associated with Increased Risk for Mortality Among Hospitalized Patients with COVID‐19 date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Obesity has been identified as a risk factor for severe COVID‐19 caused by the SARS‐CoV2 virus, however a direct association with mortality has not been reported. We sought to determine whether obesity is a risk factor for mortality among COVID‐19 patients. METHODS: The study was a retrospective cohort, including patients with COVID‐19 between March 1 and April 18, 2020. The primary objective was to determine if obesity is a predictor of mortality. RESULTS: A total of 238 patients were included, 218 patients (91.6%) were African American, 113 (47.5%) were male, and the mean age was 58.5 years. Of the included patients, 146 (61.3%) were obese (BMI >30kg/m(2)), with 63 (26.5%), 29 (12.2%), and 54 (22.7%) with class 1, 2, and 3 obesity, respectively. Obesity was identified as a predictor for mortality (OR 1.7(1.1‐2.8),p=0.016), as was male gender (OR 5.2(1.6‐16.5),p=0.01) and older age (OR 3.6(2.0‐6.3),p<0.0005). Obesity (OR 1.7(1.3‐2.1),p<0.0005) and older age (OR 1.3(1.0‐1.6),p=0.03) were also risk factors for hypoxemia. CONCLUSIONS: Obesity was found to be a significant predictor for mortality among inpatients with COVID‐19 after adjusting for age, gender, and other comorbidities. Patients with obesity were also more likely to present with hypoxemia. url: https://doi.org/10.1002/oby.22941 doi: 10.1002/oby.22941 id: cord-352159-qx16i7s1 author: Pettit, Natasha N. title: Late Onset Infectious Complications and Safety of Tocilizumab in the Management of COVID‐19 date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Tocilizumab (TCZ) has been used in the management of COVID‐19‐related cytokine release syndrome (CRS). Concerns exist regarding the risk of infections and drug‐related toxicities. We sought to evaluate the incidence of these TCZ complications among COVID‐19 patients. METHODS: All adult inpatients with COVID‐19 between March 1(st) and April 25(th), 2020 that received TCZ were included. We compared the rate of late‐onset infections (>48 hours following admission) to a control group matched according to intensive care unit admission and mechanical ventilation requirement. Post‐TCZ toxicities evaluated included: elevated liver function tests (LFTs), GI perforation, diverticulitis, neutropenia, hypertension, allergic reactions, and infusion‐related reactions. RESULTS: Seventy‐four patients were included in each group. Seven‐teen infections in the TCZ group (23%) and 6 (8%) infections in the control group occurred >48 hours after admission (p=0.013). Most infections were bacterial with pneumonia being the most common manifestation. Among patients receiving TCZ, LFT elevations were observed in 51%, neutropenia in 1.4%, and hypertension in 8%. The mortality rate among those that received TCZ was greater than the control (39% versus 23%, p=0.03). CONCLUSION: Late onset infections were significantly more common among those receiving TCZ. Combining infections and TCZ‐related toxicities, 61% of patients had a possible post‐TCZ complication. While awaiting clinical trial results to establish the efficacy of TCZ for COVID‐19 related CRS, the potential for infections and TCZ related toxicities should be carefully weighed when considering use. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/jmv.26429 doi: 10.1002/jmv.26429 id: cord-305139-851v2qr3 author: Peys, Elise title: Haemoptysis as the first presentation of COVID-19: a case report date: 2020-10-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic that profoundly challenges healthcare systems all over the world. Fever, cough and fatigue are the most commonly reported clinical symptoms. CASE PRESENTATION: A 58-year-old man presented at the emergency department with acute onset haemoptysis. On the fifth day after admission, he developed massive haemoptysis. Computed tomography (CT) angiography of the chest revealed alveolar haemorrhage, more prominent in the left lung. Flexible bronchoscopy confirmed bleeding from the left upper lobe, confirmed by a bronchial arteriography, which was successfully embolized. Nasopharyngeal swabs (NPS) tested for SARS-CoV-2 using real-time polymerase chain reaction (RT-PCR) repeatedly returned negative. Surprisingly, SARS-CoV-2 was eventually detected in bronchoalveolar lavage (BAL) fluid. CONCLUSIONS: Life-threatening haemoptysis is an unusual presentation of COVID-19, reflecting alveolar bleeding as a rare but possible complication. This case emphasises the added value of bronchoscopy with BAL in the diagnostic work-up in case of high clinical suspicion and negative serial NPS in patients presenting with severe symptoms. url: https://www.ncbi.nlm.nih.gov/pubmed/33092563/ doi: 10.1186/s12890-020-01312-6 id: cord-293547-29i3u83s author: Pfaar, O title: COVID‐19 pandemic: Practical considerations on the organization of an allergy clinic – an EAACI/ARIA Position Paper date: 2020-06-12 words: 8811.0 sentences: 512.0 pages: flesch: 42.0 cache: ./cache/cord-293547-29i3u83s.txt txt: ./txt/cord-293547-29i3u83s.txt summary: RESULTS: Based on diagnostic and treatment standards developed by EAACI, on international information regarding COVID‐19, on guidelines of the World Health Organization (WHO) and other international organizations as well as on previous experience, a panel of experts including clinicians, psychologists, IT experts and basic scientists along with EAACI and the "Allergic Rhinitis and its Impact on Asthma (ARIA)" inititiative have developed recommendations for the optimal management of allergy clinics during the current COVID‐19 pandemic. CONCLUSIONS: This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients whilst ensuring necessary safety in the current COVID‐19 pandemic. In the current SARS-CoV-2 pandemic, the European Task Force on Atopic Dermatitis (ETFAD) recommends to continue all immune-modulating treatment since exacerbations of underlying diseases can have a large negative impact on the patient''s immunity [30] . abstract: BACKGROUND: The Coronavirus disease 2019 (COVID‐19) has evolved as a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS‐CoV‐)2. Allergists and other health care providers (HCPs) in the field of allergies and associated airway diseases are in the front line, taking care of patients potentially infected with SARS‐CoV‐2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics. METHOD: The scientific information on COVID‐19 was analyzed by a literature search in Medline, Pubmed, national and international guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library and the Internet. RESULTS: Based on diagnostic and treatment standards developed by EAACI, on international information regarding COVID‐19, on guidelines of the World Health Organization (WHO) and other international organizations as well as on previous experience, a panel of experts including clinicians, psychologists, IT experts and basic scientists along with EAACI and the “Allergic Rhinitis and its Impact on Asthma (ARIA)” inititiative have developed recommendations for the optimal management of allergy clinics during the current COVID‐19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies. CONCLUSIONS: This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients whilst ensuring necessary safety in the current COVID‐19 pandemic. url: https://doi.org/10.1111/all.14453 doi: 10.1111/all.14453 id: cord-002724-gtv9syzi author: Pfortmueller, Carmen Andrea title: Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers date: 2017-10-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In critically ill patients, organ dysfunctions are routinely assessed, monitored, and treated. Mounting data show that substantial critical illness-induced changes in the immune system can be observed in most ICU patients and that not only “hyper-inflammation” but also persistence of an anti-inflammatory phenotype (as in sepsis-associated immunosuppression) is associated with increased morbidity and mortality. Despite common perception, changes in functional immunity cannot be adequately assessed by routine inflammatory biomarkers such as C-reactive protein, procalcitonin, or numerical analysis of leukocyte (sub)-counts. Cytokines appear also not suited due to their short half-life and pleiotropy, their unexclusive origin from immune cells, and their potential to undergo antagonization by circulating inactivating molecules. Thus, beyond leukocyte quantification and use of routine biomarkers, direct assessment of immune cell function seems required to characterize the immune systems’ status. This may include determination of, e.g., ex vivo cellular cytokine release, phagocytosis activity, and/or antigen-presenting capacity. In this regard, standardized flow-cytometric assessment of the major histocompatibility-II complex human leukocyte antigen (-D related) (HLA-DR) has gained particular interest. Monocytic HLA-DR (mHLA-DR) controls the interplay between innate and adaptive immunity and may serve as a “global” biomarker of injury-associated immunosuppression, and its decreased expression is associated with adverse clinical outcomes (e.g., secondary infection risk, mortality). Importantly, recent data demonstrate that injury-associated immunosuppression can be reversed—opening up new therapeutic avenues in affected patients. Here we discuss the potential scientific and clinical value of assessment of functional immunity with a focus on monocytes/macrophages and review the current state of knowledge and potential perspectives for affected critically ill patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653680/ doi: 10.1186/s40635-017-0163-0 id: cord-333375-d7cgvjsm author: Phoon, Laiyee title: Recommendations on diagnosis and treatment in hepatobiliary surgery under 2019-nCoV epidemic date: 2020-06-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: 2019 novel coronavirus pneumonia is a serious life-threatening disease and it has affected many people globally, especially the people who live in China. A high prevalence of hepatobiliary diseases has been observed in 2019-nCoV patients and some may require emergency surgery. In the context of the novel coronavirus pneumonia, new challenges have arisen for surgeons in terms of ways to effectively treat outpatients, safety of medical staffs in performing surgery treatment, and the lack of efficient postoperative management and follow-up procedure. It is hoped that through this article, surgeons will have a better system in hepatobiliary diseases classification, treatment selection, and protective measures to improve the clinical practice in accordance with the guidelines for the diagnosis and treatment of the novel coronavirus pneumonia. url: https://api.elsevier.com/content/article/pii/S2210740120301510 doi: 10.1016/j.clinre.2020.04.021 id: cord-337644-aobdzwpx author: Pianta, L. title: Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19 date: 2020-05-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: SARS-CoV-2 is a new pandemic influenza caused by a coronavirus which main route of transmission is through exhaled droplets that primarily infect the nose and the nasopharynx. The aim of this paper is to evaluate the effect of acetic acid, the active component of vinegar, as a potential disinfectant agent for upper airways. METHODS: Twenty-nine patients were enrolled and divided into two groups: group 1 (14 patients) was composed of patients treated with off-label hydroxychloroquine and lopinavir/ritonavir, whereas group 2 (15 patients) was composed of patients treated with hydroxychloroquine only, combined with the inhalation of acetic acid disinfectant at a 0.34% concentration. A questionnaire-based evaluation of symptoms was performed after 15 days in both groups. RESULTS: It appears that the number of patients treated with acetic acid (group 2) that experienced improvement in individual symptoms was double that of the other group of patients (group 1), although numbers are too small for robust statistical analysis. CONCLUSIONS: Considering its potential benefits and high availability, acetic acid disinfection appears to be a promising adjunctive therapy in cases of non-severe COVID-19 and deserves further investigation. url: https://doi.org/10.1007/s00405-020-06067-8 doi: 10.1007/s00405-020-06067-8 id: cord-355028-1x7w1749 author: Piazza, Cesare title: Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society date: 2020-06-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The novel Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, may need intensive care unit (ICU) admission in up to 12% of all positive cases for massive interstitial pneumonia, with possible long-term endotracheal intubation for mechanical ventilation and subsequent tracheostomy. The most common airway-related complications of such ICU maneuvers are laryngotracheal granulomas, webs, stenosis, malacia and, less commonly, tracheal necrosis with tracheo-esophageal or tracheo-arterial fistulae. MATERIALS AND METHODS: This paper gathers the opinions of experts of the Laryngotracheal Stenosis Committee of the European Laryngological Society, with the aim of alerting the medical community about the possible rise in number of COVID-19-related laryngotracheal stenosis (LTS), and the aspiration of paving the way to a more rationale concentration of these cases within referral specialist airway centers. RESULTS: A range of prevention strategies, diagnostic work-up, and therapeutic approaches are reported and framed within the COVID-19 pandemic context. CONCLUSIONS: One of the most important roles of otolaryngologists when encountering airway-related signs and symptoms in patients with previous ICU hospitalization for COVID-19 is to maintain a high level of suspicion for LTS development, and share it with colleagues and other health care professionals. Such a condition requires specific expertise and should be comprehensively managed in tertiary referral centers. url: https://www.ncbi.nlm.nih.gov/pubmed/32506145/ doi: 10.1007/s00405-020-06112-6 id: cord-278536-b4eyegx5 author: Piazza, Gregory title: Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19 date: 2020-11-03 words: 1467.0 sentences: 93.0 pages: flesch: 34.0 cache: ./cache/cord-278536-b4eyegx5.txt txt: ./txt/cord-278536-b4eyegx5.txt summary: OBJECTIVES: To assess the frequency of arterial and venous thromboembolic disease, risk factors, prevention and management patterns, and outcomes in patients with COVID-19, the authors designed a multicenter, observational cohort study. CONCLUSIONS: Major arterial or venous thromboembolism, major adverse cardiovascular events, and symptomatic venous thromboembolism occurred with high frequency in patients with COVID-19, especially in the intensive care setting, despite a high utilization rate of thromboprophylaxis. Whereas the morbidity and mortality associated with COVID-19 are usually attributed to acute respiratory distress syndrome (ARDS) and end-organ failure, cardiovascular complications, including myocardial infarction (MI), ischemic stroke, and pulmonary embolism (PE), also cause disability and death in these patients (1) (2) (3) . Among those admitted to the non-ICU setting (n ¼ 229), the frequency of major arterial or venous thromboembolism, major adverse cardiovascular events, and symptomatic VTE was also elevated but lower than for those with critical illness. abstract: BACKGROUND: Cardiovascular complications, including myocardial infarction, ischemic stroke, and pulmonary embolism, represent an important source of adverse outcomes in coronavirus disease-2019 (COVID-19). OBJECTIVES: To assess the frequency of arterial and venous thromboembolic disease, risk factors, prevention and management patterns, and outcomes in patients with COVID-19, the authors designed a multicenter, observational cohort study. METHODS: We analyzed a retrospective cohort of 1,114 patients with COVID-19 diagnosed through our Mass General Brigham integrated health network. The total cohort was analyzed by site of care: intensive care (n = 170); hospitalized nonintensive care (n = 229); and outpatient (n = 715). The primary study outcome was a composite of adjudicated major arterial or venous thromboembolism. RESULTS: Patients with COVID-19 were 22.3% Hispanic/Latinx and 44.2% non-White. Cardiovascular risk factors of hypertension (35.8%), hyperlipidemia (28.6%), and diabetes (18.0%) were common. Prophylactic anticoagulation was prescribed in 89.4% of patients with COVID-19 in the intensive care cohort and 84.7% of those in the hospitalized nonintensive care setting. Frequencies of major arterial or venous thromboembolism, major cardiovascular adverse events, and symptomatic venous thromboembolism were highest in the intensive care cohort (35.3%, 45.9%, and 27.0 %, respectively) followed by the hospitalized nonintensive care cohort (2.6%, 6.1%, and 2.2%, respectively) and the outpatient cohort (0% for all). CONCLUSIONS: Major arterial or venous thromboembolism, major adverse cardiovascular events, and symptomatic venous thromboembolism occurred with high frequency in patients with COVID-19, especially in the intensive care setting, despite a high utilization rate of thromboprophylaxis. url: https://www.sciencedirect.com/science/article/pii/S0735109720365906 doi: 10.1016/j.jacc.2020.08.070 id: cord-295523-5pv7kw6i author: Picchianti Diamanti, Andrea title: Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity date: 2020-05-08 words: 7905.0 sentences: 390.0 pages: flesch: 39.0 cache: ./cache/cord-295523-5pv7kw6i.txt txt: ./txt/cord-295523-5pv7kw6i.txt summary: However, in about 20% of patients, the infection progresses to severe interstitial pneumonia and can induce an uncontrolled host-immune response, leading to a life-threatening condition called cytokine release syndrome (CRS). We critically review the rationale for the adoption of immunosuppressive agents, commonly used in autoimmune diseases, in the treatment of SARS-CoV-2 infection and report current knowledge of ongoing studies. The exacerbated reaction to infections or to biological therapy is caused by the rapid recruitment of macrophages and neutrophils, which produce pro-inflammatory cytokines and alter the fragile balance between a controlled immune response and a host-damaging reaction. As of now, four clinical trials are recruiting patients with COVID-19, severe acute respiratory failure, and CRS, aiming at evaluating the safety and effectiveness of anakinra alone or in combination with anti-IL-6 agents (NCT04330638, NCT0432402, NCT04357366, NCT04339712). High disease activity is associated with an increased risk of infection in patients with rheumatoid arthritis abstract: On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency. Typical manifestations consist of flu-like symptoms such as fever, cough, fatigue, and dyspnea. However, in about 20% of patients, the infection progresses to severe interstitial pneumonia and can induce an uncontrolled host-immune response, leading to a life-threatening condition called cytokine release syndrome (CRS). CRS represents an emergency scenario of a frequent challenge, which is the complex and interwoven link between infections and autoimmunity. Indeed, treatment of CRS involves the use of both antivirals to control the underlying infection and immunosuppressive agents to dampen the aberrant pro-inflammatory response of the host. Several trials, evaluating the safety and effectiveness of immunosuppressants commonly used in rheumatic diseases, are ongoing in patients with COVID-19 and CRS, some of which are achieving promising results. However, such a use should follow a multidisciplinary approach, be accompanied by close monitoring, be tailored to patient’s clinical and serological features, and be initiated at the right time to reach the best results. Autoimmune patients receiving immunosuppressants could be prone to SARS-CoV-2 infections; however, suspension of the ongoing therapy is contraindicated to avoid disease flares and a consequent increase in the infection risk. url: https://www.ncbi.nlm.nih.gov/pubmed/32397174/ doi: 10.3390/ijms21093330 id: cord-034185-e0am7pa6 author: Piccioni, Federico title: Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date: 2020-10-23 words: 18220.0 sentences: 941.0 pages: flesch: 37.0 cache: ./cache/cord-034185-e0am7pa6.txt txt: ./txt/cord-034185-e0am7pa6.txt summary: We do not recommend the routine use of either continuous positive airway pressure (CPAP) or non invasive ventilation (NIV) to prevent postoperative pulmonary complications, prolonged length of stay, and mortality (both in ICU and in hospital) in patients undergoing major thoracic surgery. Level of evidence: Fair Strength of recommendation: C A meta-analysis of 45 studies including almost 5800 patients showed that a single perioperative dose of intravenous dexamethasone resulted in significant reductions in pain scores and opioid use, and was associated with shorter stays in the post-anesthesia recovery room, compared with placebo or antiemetic treatment (Waldron et al. Level of evidence: Fair Strength of recommendation: A Multiple clinical trials have shown that, in patients undergoing open thoracotomy or other major surgical procedures, thoracic epidural analgesia (TEA) is superior to intravenous opioid administration in terms of postoperative pain relief, length of hospital stay, and incidence of postoperative complications (Hazelrigg et al. abstract: INTRODUCTION: Anesthetic care in patients undergoing thoracic surgery presents specific challenges that require a multidisciplinary approach to management. There remains a need for standardized, evidence-based, continuously updated guidelines for perioperative care in these patients. METHODS: A multidisciplinary expert group, the Perioperative Anesthesia in Thoracic Surgery (PACTS) group, was established to develop recommendations for anesthesia practice in patients undergoing elective lung resection for lung cancer. The project addressed three key areas: preoperative patient assessment and preparation, intraoperative management (surgical and anesthesiologic care), and postoperative care and discharge. A series of clinical questions was developed, and literature searches were performed to inform discussions around these areas, leading to the development of 69 recommendations. The quality of evidence and strength of recommendations were graded using the United States Preventive Services Task Force criteria. RESULTS: Recommendations for intraoperative care focus on airway management, and monitoring of vital signs, hemodynamics, blood gases, neuromuscular blockade, and depth of anesthesia. Recommendations for postoperative care focus on the provision of multimodal analgesia, intensive care unit (ICU) care, and specific measures such as chest drainage, mobilization, noninvasive ventilation, and atrial fibrillation prophylaxis. CONCLUSIONS: These recommendations should help clinicians to improve intraoperative and postoperative management, and thereby achieve better postoperative outcomes in thoracic surgery patients. Further refinement of the recommendations can be anticipated as the literature continues to evolve. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582032/ doi: 10.1186/s13741-020-00159-z id: cord-255393-aknebauo author: Piccoli, Giorgina Barbara title: Setting the clock back: new hope for dialysis patients. Sodium thiosulphate and the regression of vascular calcifications date: 2020-05-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32418117/ doi: 10.1007/s40620-020-00744-x id: cord-018638-4pyjhpbk author: Pilania, Rakesh Kumar title: Kawasaki Disease date: 2019-10-30 words: 5674.0 sentences: 378.0 pages: flesch: 50.0 cache: ./cache/cord-018638-4pyjhpbk.txt txt: ./txt/cord-018638-4pyjhpbk.txt summary: Acute non-purulent cervical lymphadenopathy Table 4 .2 AHA 2017 diagnostic criteria for KD [28] Diagnosis of classic KD can be proffered in the presence of fever for at least 5 days associated with at least 4 of the 5 following principal clinical features. Cervical lymphadenopathy (>1.5 cm diameter), usually unilateral A careful history may reveal that ≥1 principal clinical features were present during the illness but resolved by the time of presentation Exclusion of other diseases with similar findings (e.g., scarlet fever, viral infections like measles, adenovirus, enterovirus, Stevens-Johnson syndrome, toxic shock syndrome, drug hypersensitivity reactions, systemic juvenile idiopathic arthritis) unusual for KD. Perianal desquamation is virtually pathognomonic of KD and is a useful clinical sign for diagnosis of the disease during the acute phase ( Fig. 4 .3c). Epidemiological and clinical characteristics of Kawasaki disease and factors associated with coronary artery abnormalities in East China: nine years experience abstract: Kawasaki disease (KD) is the commonest cause of acquired heart disease in children in the developed world and is increasingly being reported from developing countries. KD has a predilection for the coronary arteries. Etiology of this disorder is remains an enigma. Diagnosis of KD is essentially clinical with the help of set of clinical criteria. Incomplete KD is said to occur when these criteria are not fulfilled. However, incomplete KD should not be considered as a milder form of the disease. 2D-echocardiography remains the imaging modality of choice for evaluation and monitoring of cardiac complications but often needs to be supplemented by CT coronary angiography. Intravenous immunoglobulin along with aspirin is the gold standard therapy of treatment for KD. However, there is no consensus on treatment of resistant forms of KD. Patients with KD should be on long-term follow-up especially if they have developed coronary artery abnormalities during the acute stage. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123566/ doi: 10.1007/978-3-030-19055-2_4 id: cord-282912-jegpgqqi author: Pilato, Emanuele title: Mechanical complications of Myocardial Infarction during Covid-19 Pandemic: An Italian single-Centre experience: Heart ruptures in covid-19 era date: 2020-09-18 words: 1393.0 sentences: 64.0 pages: flesch: 44.0 cache: ./cache/cord-282912-jegpgqqi.txt txt: ./txt/cord-282912-jegpgqqi.txt summary: This phenomenon caused a significant reduction in acute coronary syndrome-related interventional procedures with a subsequent increase in critical hospitalizations and post-infarction mechanical complications. A case series of cardiac ruptures during the COVID-19 lockdown and the surgical treatment of a huge post-ischemic cardiac pseudoaneurysm complicated by a "contained" free wall rupture are presented. Serum analysis and ECG were negative for a new ACS, but the echocardiogram revealed the presence of a huge dilatation of the cardiac apex (6.5 cm x 5.2 cm) complicated by subacute rupture of its posterior wall and by organized thrombosis inside it (figure 1A). All patients were discharged in very good general state but this report, in our opinion, demonstrated and confirmed two key points of the ACS treatment: early coronary revascularization reduces significantly the incidence of the mechanical complication but COVID-19 pandemic could completely thwart these prevention strategies and change the cardiac surgery population that we will have to deal with in the next months [5] . abstract: COVID-19 pandemic triggered in many patients the fear to go to the emergency rooms in order to avoid a possible infection. This phenomenon caused a significant reduction in acute coronary syndrome-related interventional procedures with a subsequent increase in critical hospitalizations and post-infarction mechanical complications. A case series of cardiac ruptures during the COVID-19 lockdown and the surgical treatment of a huge post-ischemic cardiac pseudoaneurysm complicated by a “contained” free wall rupture are presented. url: https://api.elsevier.com/content/article/pii/S014795632030371X doi: 10.1016/j.hrtlng.2020.09.004 id: cord-009360-rgwe2pkx author: Pilatz, Adrian title: High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval date: 2019-08-27 words: 4284.0 sentences: 228.0 pages: flesch: 36.0 cache: ./cache/cord-009360-rgwe2pkx.txt txt: ./txt/cord-009360-rgwe2pkx.txt summary: Considering infection/inflammation to be an important risk factor in male infertility, the aim of this study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients. Considering infection/inflammation to be an important risk factor in male infertility and the frequent presence of pathogens within the seminal tract, the aim of this prospective study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients undergoing testicular biopsy/TESE. To the best of our knowledge, this is the first prospective study which set out to comprehensively evaluate infection and inflammation in patients presenting with azoospermia using a 2-glass test and analysis of semen, testicular fluid and testicular tissue by measuring inflammatory parameters and performing systematic microbiological investigations. abstract: Considering infection/inflammation to be an important risk factor in male infertility, the aim of this study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients. In this prospective study, 71 patients with azoospermia were subjected to an extensive andrological workup including comprehensive microbiological diagnostics (2‐glass test, semen, testicular swab and testicular tissue analysis) and testicular biopsy/testicular sperm extraction (TESE). Medical history suggested urogenital tract infection/inflammation in 7% of patients, 11% harboured STIs, 14% showed significant bacteriospermia, 15% had seminal inflammation, 17% fulfilled the MAGI definition, and 27% had relevant pathogens. At the testicular level, 1 patient had a swab positive for bacteria, no viruses were detected, tissue specimens never indicated pathogens, whereas histopathology revealed focal immune cell infiltrates in 23% of samples. Testicular sperm retrieval rate was 100% in obstructive and 46% in nonobstructive azoospermia. None of the infection/inflammation‐related variables was associated with the success of sperm retrieval or inflammatory lesions in the testis. The high prevalence of urogenital infection/inflammation among azoospermic men underpins their role as significant aetiologic factors in male infertility. However, this observation does not refer to the chances of sperm retrieval at the time of surgery/TESE. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147116/ doi: 10.1111/and.13401 id: cord-333654-8rg99di5 author: Pillai, Presaad title: COVID-19 AND MAJOR ORGAN THROMBOEMBOLISM: MANIFESTATIONS IN NEUROVASCULAR AND CARDIOVASCULAR SYSTEMS. date: 2020-10-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause multisystemic damage. We undertook a systematic literature review and comprehensive analysis of a total of 55 articles on arterial and venous thromboembolism in COVID-19 and articles on previous pandemics with respect to thromboembolism and compared the similarities and differences between them. The presence of thrombosis in multiple organ systems points to thromboembolism being an integral component in the pathogenesis of this disease. Thromboembolism is likely to be the main player in the morbidity and mortality of COVID -19 in which the pulmonary system is most severely affected. We also hypothesize that D-dimer values could be used as an early marker for prognostication of disease as it has been seen to be raised even in the pre-symptomatic stage. This further strengthens the notion that thromboembolism prevention is necessary. We also examined literature on the cerebrovascular and cardiovascular systems, as the manifestation of thromboembolic phenomenon in these two systems varied, suggesting different pathophysiology of damage. Further research into the role of thromboembolism in COVID-19 is important to advance the understanding of the virus, its effects and to tailor treatment accordingly to prevent further casualties from this pandemic. url: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105427 doi: 10.1016/j.jstrokecerebrovasdis.2020.105427 id: cord-006545-c12m75gq author: Pinilla, Inmaculada title: Radiological prognostic factors in patients with pandemic H1N1 (pH1N1) infection requiring hospital admission date: 2011-05-27 words: 3045.0 sentences: 169.0 pages: flesch: 45.0 cache: ./cache/cord-006545-c12m75gq.txt txt: ./txt/cord-006545-c12m75gq.txt summary: The aim of this study was to determine the radiologic findings associated with admission to the intensive care unit (ICU) and the development of acute respiratory distress syndrome (ARDS) in patients with pH1N1 infection. A higher number of lung zones involved and consolidation on the initial chest radiograph as well as a rapid progression of the radiological abnormalities were identified in patients requiring ICU admission and development of ARDS. Several reports describe the initial radiographic and CT findings in patients with H1N1 infection of both mild and severe cases including interstitial markings, nodules, ground-glass opacities (GGO), and consolidations with focal, multifocal, or diffuse distribution [8] [9] [10] [11] [12] [13] [14] [15] . The presence on the initial chest radiograph of lung consolidation, multifocal, diffuse, and bilateral involvement (Fig. 2 ) was associated with a statistically higher risk of requiring ICU admission (p<0.001). abstract: The aim of this study was to determine the radiologic findings associated with admission to the intensive care unit (ICU) and the development of acute respiratory distress syndrome (ARDS) in patients with pH1N1 infection. One hundred and four patients (15–96 years) with laboratory-confirmed pH1N1 infection seen at the Emergency Department from July to December 2009 who underwent chest radiographs were studied. Radiographs were evaluated for consolidation, ground-glass opacities, interstitial patterns, distribution, and extent of findings. Eighty-seven (83.7%) of the patients were managed in the ward, and 17 (16.3%) patients eventually required admission to the ICU. All patients admitted to the ICU showed abnormalities on the initial radiograph. The presence of consolidation, multifocal, diffuse, and bilateral involvement on the initial radiograph was associated with a statistically higher risk of requiring ICU admission (p < 0.001). There were no significant differences regarding age, sex, and presence of underlying comorbidities. Evolution to ARDS was found in eight cases that necessitated ICU care. All of them had on the initial radiograph patchy multifocal consolidations (p < 0.001) with bilateral lesions in six cases. A higher number of lung zones involved and consolidation on the initial chest radiograph as well as a rapid progression of the radiological abnormalities were identified in patients requiring ICU admission and development of ARDS. Initial chest radiographs show acute abnormalities in all patients with severe disease. The findings of a multifocal patchy consolidation pattern with bilateral or diffuse lung involvement on admission should alert of the impending severity of disease and the risk of necessitating ICU admission url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102002/ doi: 10.1007/s10140-011-0964-5 id: cord-267287-qodj254z author: Pintado, Juan F. title: How COVID-19 has affected Emergent Visits to a Latin-American Trauma Department: Experience at a Peruvian National Trauma Referral Center date: 2020-11-03 words: 3661.0 sentences: 180.0 pages: flesch: 49.0 cache: ./cache/cord-267287-qodj254z.txt txt: ./txt/cord-267287-qodj254z.txt summary: The current study''s overall aim was to examine the impact of the current COVID-19 outbreak on the number of non-COVID-related patient presentations to a major national emergency traumatology/orthopedics referral center in Latin America. Numbers of non-follow-up patients presenting to the traumatology/ orthopedics service were counted and compared between January through April 2019 and January through April 2020; and between the month immediately prior to the Peruvian government''s implementation of national lock-down measures (Feb 16—Mar 15; Period 1) and the month immediately following (Mar 16—Apr 15; Period 2). Our institute, which performs more trauma and orthopedic surgeries than any other center in Peru [6] , was declared a national referral center for patients with suspected or confirmed COVID-19 during the pandemic. On the other hand, strengths include it being the first to report on the impact of the present global crisis on Latin-American traumatology and orthopedic services, and that our institution is our country''s largest tertiary referral center for trauma cases within the Peruvian National Health Service. abstract: Introduction: By May 2020, Peru was the country with the third most COVID-19 cases in the Americas. The current study's overall aim was to examine the impact of the current COVID-19 outbreak on the number of non-COVID-related patient presentations to a major national emergency traumatology/orthopedics referral center in Latin America. Methods: An observational study was performed at one of Peru's main tertiary trauma referral centers, during the current COVID-19 pandemic. Numbers of non-follow-up patients presenting to the traumatology/ orthopedics service were counted and compared between January through April 2019 and January through April 2020; and between the month immediately prior to the Peruvian government's implementation of national lock-down measures (Feb 16—Mar 15; Period 1) and the month immediately following (Mar 16—Apr 15; Period 2). The number of surgery service hospitalizations also was compared pre- versus post lockdown initiation (Period 1 vs. 2), as were patient characteristics and outcomes, like age, sex, discharge disposition, mortality, indications for hospital admission, and COVID-19 status. Results: Comparing 2019 and 2020, no appreciable differences were detected in the number of patients seen in either January or February. However, relative to March and April 2019, the numbers of patients seen in March and April 2020 (the two months after the first Peruvian case of COVID-19 was detected) were reduced by 55.8 and 88.6%, respectively. Comparing the months immediately pre and post lockdown, the number of service patients declined by 79.9% in April, while the number of hospitalizations declined by 30.9%. The number of admissions for various surgical indications either remained stable or declined in parallel with the overall decline in admissions for all indications except for osteoporotic hip fractures and diabetic foot ulcers (both of which increased proportional to the overall number of admissions) and for hand and foot fractures, both of which decreased. Conclusion: At our hospital, not all indications for traumatology/orthopedics service utilization declined despite the national government's directive to reduce non-COVID-related consultations and admissions. Some disorders presented with even greater frequency, which must be considered when developing contingencies for the reallocation of healthcare resources during a pandemic. url: https://www.sciencedirect.com/science/article/pii/S002013832030930X?v=s5 doi: 10.1016/j.injury.2020.11.005 id: cord-345779-frspku51 author: Pinto, Antonio title: Interventional radiology in gynaecology and obstetric practice: safety issues date: 2020-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Interventional radiology is continuing to reshape current practice in many specialties of clinical care and the fields of gynaecology and obstetrics are no exception. Imaging skills, clinical knowledge as well as vascular and non-vascular interventional technical ability, are essential to practice interventional radiology effectively. Patient safety is of paramount importance in interventional radiology as in all branches of medicine. Potential failures occur throughout successful procedures and are attributed to a spectrum of errors, including equipment unavailability, planning errors, and communication errors. These are mainly preventable by improved preprocedural planning and teamwork. Of all the targeted and effective actions that can be undertaken to reduce adverse events, the use of safety checklists might have a prominent role. The advantage of a safety checklist for interventional radiology is that it guarantees that human error in terms of forgetting key steps in patient preparation, intraprocedural care, and postoperative care are not forgotten. url: https://www.sciencedirect.com/science/article/pii/S0887217120301220?v=s5 doi: 10.1053/j.sult.2020.09.004 id: cord-027551-a92lv4sh author: Pinto, Eleonora title: QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer date: 2020-06-22 words: 4415.0 sentences: 219.0 pages: flesch: 38.0 cache: ./cache/cord-027551-a92lv4sh.txt txt: ./txt/cord-027551-a92lv4sh.txt summary: We have therefore hypothesized that, similar to what was observed with the sleep impairment [16] , the early postoperative HRQL could be improved by ameliorating the quality of nutrition and respiration after esophagectomy and designing a randomized control trial to assess if the adoption of nutritional and respiratory counseling may be effective in enhancing the quality of postoperative QoL after esophagectomy for cancer. This randomized controlled trial aimed to assess the effectiveness of nutritional counseling and/or respirology counseling on postoperative quality of life after esophagectomy for cancer. Thus, the aim of this study was to evaluate the effect of the nutritional and respiratory counseling on quality of life after esophagectomy for cancer. However, nutritional counseling did not influence appetite loss, global quality of life, or eating issues at 3 months after surgery, and receiving nutritional counseling did not result in any significant changes in additional nutritional measures (PA, FFm, Kcal, prot, BMI). Feb-Mar) Longterm nutritional outcome and health related quality of life of patients following esophageal cancer surgery: a meta-analysis abstract: BACKGROUND: Esophagectomy for cancer strongly impairs quality of life. The aim of this trial was to evaluate the effect of the nutritional and respiratory counseling on postoperative quality of life. METHODS: At hospital discharge, patients were randomized into four groups receiving respectively: nutritional and respiratory counseling, nutritional counseling alone, respiratory counseling alone, or standard care. The main endpoint was the impairment in quality of life in the first month after surgery. Linear mixed effect models were estimated to assess mean score differences (MDs) in quality of life scores. RESULTS: Patients receiving nutritional counseling reported less appetite loss (MD − 17.7, 95% CI − 32.2 to −3.3) than those not receiving nutritional counseling at 1 month after surgery. Dyspnea was similar between patients receiving vs. those not receiving respiratory counseling (MD − 3.1, 95% CI − 10.8 to 4.6). Global quality of life was clinically similar between patients receiving vs. those not receiving nutritional counseling over time (MD 0.9, 95% CI − 5.5 to 7.3), as well as in patients receiving vs. those not receiving respiratory counseling over time (MD 0.7, 95% CI − 5.9 to 7.2). CONCLUSIONS: Intensive postoperative care does not affect global quality of life even if nutritional counseling reduced appetite loss. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00520-020-05573-z) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307937/ doi: 10.1007/s00520-020-05573-z id: cord-340786-12vzsl6p author: Pinto, Susana title: New technologies and Amyotrophic Lateral Sclerosis – Which step forward rushed by the COVID-19 pandemic? date: 2020-08-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Amyotrophic Lateral Sclerosis (ALS) is a fast-progressive neurodegenerative disease leading to progressive physical immobility with usually normal or mild cognitive and/or behavioural involvement. Many patients are relatively young, instructed, sensitive to new technologies, and professionally active when developing the first symptoms. Older patients usually require more time, encouragement, reinforcement and a closer support but, nevertheless, selecting user-friendly devices, provided earlier in the course of the disease, and engaging motivated carers may overcome many technological barriers. ALS may be considered a model for neurodegenerative diseases to further develop and test new technologies. From multidisciplinary teleconsults to telemonitoring of the respiratory function, telemedicine has the potentiality to embrace other fields, including nutrition, physical mobility, and the interaction with the environment. Brain-computer interfaces and eye tracking expanded the field of augmentative and alternative communication in ALS but their potentialities go beyond communication, to cognition and robotics. Virtual reality and different forms of artificial intelligence present further interesting possibilities that deserve to be investigated. COVID-19 pandemic is an unprecedented opportunity to speed up the development and implementation of new technologies in clinical practice, improving the daily living of both ALS patients and carers. The present work reviews the current technologies for ALS patients already in place or being under evaluation with published publications, prompted by the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32882437/ doi: 10.1016/j.jns.2020.117081 id: cord-328214-2azb8789 author: Piper-Vallillo, Andrew J. title: COVID-19 Infection in a Lung Cancer Patient Population: Incidence, Presentation and Alternative Diagnostic Considerations date: 2020-11-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction Lung cancer is associated with severe COVID-19 infections. Symptom overlap between COVID-19 and lung cancer may complicate diagnostic evaluation. We aimed to investigate the incidence, symptoms, differential diagnosis, and outcomes of COVID-19 in lung cancer patients. Methods To determine an at-risk population for COVID-19, we retrospectively identified lung cancer patients receiving longitudinal care within a single institution in the 12 months (4/1/19 – 3/31/20) immediately preceding the COVID-19 pandemic, including an “active therapy population” treated within the last 60 days of this period. Among patients subsequently referred for COVID-19 testing, we compared symptoms, laboratory/radiographic findings, and outcomes of positive versus negative patients. Results Between 4/1/2019-3/31/2020, 696 patients received longitudinal care, including 406 (58%) in the active therapy population. Among 55 patients referred for COVID-19 testing, 24 (44%) were COVID-19 positive, representing a cumulative incidence of 3.4% (longitudinal population) and 1.5% (active therapy population). Compared to COVID-19-negative patients, COVID-19-positive patients were more likely to have a supplemental oxygen requirement (11% vs. 54%, p=0.005) and to have typical COVID-19 pneumonia imaging findings (5 vs. 56%, p=0.001). Otherwise, there were no significant differences in presenting symptoms. Among COVID-negative patients, alternative etiologies included treatment-related toxicity (26%), atypical pneumonia (22%), and disease progression (22%). Sixteen COVID-19-postive patients (67%) required hospitalization, and 7 (29%) died from COVID-related complications. Conclusions COVID-19 was infrequent in this lung cancer population, but these patients experienced high rates of morbidity and mortality. Oncologists should maintain a low threshold for COVID-19 testing in lung cancer patients presenting with acute symptoms. url: https://www.sciencedirect.com/science/article/pii/S2666364320301752?v=s5 doi: 10.1016/j.jtocrr.2020.100124 id: cord-309441-obojsf04 author: Pirau, Letitia title: Case Series: Evidence of Borderzone Ischemia in Critically-Ill COVID-19 Patients Who “Do Not Wake Up” date: 2020-09-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This article describes the clinical course, radiological findings, and outcome of two patients with the novel 2019 coronavirus disease (COVID-19) who remained comatose for a prolonged duration following discontinuation of all sedation. These two male patients, one aged 59-years and another aged 53-years, both with a history of hypertension and neurologically intact on admission, developed worsening COVID-19 associated acute respiratory distress syndrome (ARDS). Both required benzodiazepine, opioid, neuromuscular blockade, therapeutic anticoagulation, and vasopressor infusions in addition to renal replacement therapy. Echocardiography demonstrated normal chamber size and systolic function in both cases. Each patient demonstrated only trace flexion to pain 7–10 days following discontinuation of all sedation. Magnetic Resonance Imaging on both patients demonstrated multifocal lesions on diffusion weighted imaging with apparent diffusion coefficient correlate in bilateral middle/anterior cerebral artery borderzones, and no large-vessel occlusion or severe stenosis. In both patients, continuous electroencephalography demonstrated no seizures. Neither patient had any documented period of sustained hypotension (mean arterial pressure <60 mmHg) or hypoxia (SpO(2) <90%). Ninety days following initial presentation, the 59-years-old man was oriented, with fluent speech and able to ambulate with assistance, while the other 53-years-old man was at home and independent, undertaking the basic activities required by daily living. We conclude that critically-ill COVID-19 patients with prolonged coma following sedation discontinuation may demonstrate imaging features of ischemic injury in borderzone regions despite the absence of documented sustained hypotension or hypoxia. However, substantial neurological recovery is possible despite these findings. url: https://doi.org/10.3389/fneur.2020.00964 doi: 10.3389/fneur.2020.00964 id: cord-022594-fx044gcd author: Pirko, Istvan title: Demyelinating Disorders of the Central Nervous System date: 2009-05-18 words: 25103.0 sentences: 1371.0 pages: flesch: 46.0 cache: ./cache/cord-022594-fx044gcd.txt txt: ./txt/cord-022594-fx044gcd.txt summary: If a patient presents with a history of two or more attacks, but objective clinical evidence only suggests one lesion, the following additional data is needed to confirm the diagnosis: the disease process has to be disseminated in space as demonstrated by MRI; alternatively, two or more MRI-detected lesions consistent with MS plus positive CSF would suffice to meet the newly defined criteria. The EBM calculations regarding this trial show an RRR of 24%, and ARR of 11%, and an NNT of 9 patients over 2 years in order to prevent one conversion to "clinically definite MS." These two studies provide support for considering early treatment in patients presenting with first attack, in the presence of multiple asymptomatic MRI lesions, but further studies are needed to determine whether this approach will provide a prolonged benefit on disease course. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158368/ doi: 10.1016/b978-141603618-0.10048-7 id: cord-297208-f4ob3ox6 author: Pisano, Antonio title: Cardiothoracic surgery at the time of COVID-19 pandemic: lessons from the East (and from a previous epidemic) for western battlefields date: 2020-05-06 words: 1376.0 sentences: 62.0 pages: flesch: 39.0 cache: ./cache/cord-297208-f4ob3ox6.txt txt: ./txt/cord-297208-f4ob3ox6.txt summary: 1 Evidently, countries which faced the severe acute respiratory syndrome (SARS) outbreak, the first coronavirus pandemic of the current century which affected more than 8000 people (mainly in China, Vietnam, Singapore and Canada) in 2003 7 , were much more prepared, both culturally and in terms of facilities and equipment, as compared with western countries (many of which had to face, in the initial stages of the emergency, the shortage of even simple and cheap devices such as surgical masks). abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32482506/ doi: 10.1053/j.jvca.2020.04.051 id: cord-276359-syr9av09 author: Piva, Simone title: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy date: 2020-04-14 words: 3312.0 sentences: 204.0 pages: flesch: 49.0 cache: ./cache/cord-276359-syr9av09.txt txt: ./txt/cord-276359-syr9av09.txt summary: title: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy In addition to describing the clinical management of such patients, this study details a proposed severity scale that was used to communicate with non-intensivists for management and triage, and for a step-up approach to drug therapy including antivirals, desamethasone and selective cytokine blockers. Creation of a severity scale to assess patients with COVID is of value to hospitals and physicians facing such shortages. The pandemic spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease, COVID-19, has resulted in massive strain in healthcare systems in several countries. The experience of Lombardy is interesting in that despite Italy having the third most number of ICU beds per capita, after the United States and Germany, physicians have had to limit resources due to shortages [1] . abstract: PURPOSE: An ongoing pandemic of COVID-19 that started in Hubei, China has resulted in massive strain on the healthcare infrastructure in Lombardy, Italy. The management of these patients is still evolving. MATERIALS AND METHODS: This is a single-center observational cohort study of critically ill patients infected with COVID-19. Bedside clinicians abstracted daily patient data on history, treatment, and short-term course. We describe management and a proposed severity scale for treatment used in this hospital. RESULTS: 44 patients were enrolled; with incomplete information on 11. Of the 33 studied patients, 91% were male, median age 64; 88% were overweight or obese. 45% were hypertensive, 12% had been taking an ACE-inhibitor. Noninvasive ventilation was performed on 39% of patients for part or all or their ICU stay with no provider infection. Most patients received antibiotics for pneumonia. Patients also received lopinivir/ritonavir (82%), hydroxychloroquine (79%), and tocilizumab (12%) according to this treatment algorithm. Nine of 10 patients survived their ICU course and were transferred to the floor, with one dying in the ICU. CONCLUSIONS: ICU patients with COVID-19 frequently have hypertension. Many could be managed with noninvasive ventilation, despite the risk of aerosolization. The use of a severity scale augmented clinician management. url: https://doi.org/10.1016/j.jcrc.2020.04.004 doi: 10.1016/j.jcrc.2020.04.004 id: cord-348172-q3zcn5pf author: Poli, Daniela title: Managing anticoagulation in the COVID-19 era between lockdown and reopening phases date: 2020-06-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patients on anticoagulant treatment are constantly increasing, with an estimated prevalence in Italy of 2% of the total population. The recent spreadout of the COVID-19 pandemic requires a re-organization of Anticoagulation Clinics to prevent person-to-person viral diffusion and continue to offer the highest possible quality of assistance to patients. In this paper, based on the Italian Federation of Anticoagulation Clinics statements, we offer some advice aimed at improving patient care during COVID-19 pandemic, with particular regard to the lockdown and reopening periods. We give practical guidance regarding the following points: (1) re-thinking the AC organization, (2) managing patients on anticoagulants when they become infected by the virus, (3) managing anticoagulation surveillance in non-infected patients during the lockdown period, and (4) organizing the activities during the reopening phases. url: https://doi.org/10.1007/s11739-020-02391-3 doi: 10.1007/s11739-020-02391-3 id: cord-266455-rbblg4pu author: Poole, Stephen title: Rapid syndromic molecular testing in pneumonia: The current landscape and future potential date: 2019-12-03 words: 4839.0 sentences: 232.0 pages: flesch: 35.0 cache: ./cache/cord-266455-rbblg4pu.txt txt: ./txt/cord-266455-rbblg4pu.txt summary: Syndromic diagnostic testing using novel, rapid multiplexed molecular platforms represents a new opportunity for rapidly targeted antimicrobial therapy to improve patient outcomes and facilitate antibiotic stewardship. This is an FDA approved and CE marked platform that uses nested real-time PCR to detect 34 clinically important respiratory targets (15 semi-quantitative bacterial targets, 3 qualitative atypical bacterial targets, 8 [30] [31] [32] Furthermore, the pneumonia panel detects pathogens in a much higher proportion of samples than culture. Rapid syndromic molecular platforms have the potential to significantly improve the use of antibiotics and clinical outcomes in patient with pneumonia, but high quality randomised controlled trials are urgently required to evaluate their clinical impact. an observational study comparing the performance of two multiplex PCR platforms against routine microbiology for the detection of potential pathogens in patients with suspected hospital acquired/ventilator associated pneumonia (HAP/VAP) across abstract: Community acquired pneumonia (CAP), hospital-acquired pneumonia (HAP) and ventilator associated pneumonia (VAP) are all associated with significant mortality and cause huge expense to health care services around the world. Early, appropriate antimicrobial therapy is crucial for effective treatment. Syndromic diagnostic testing using novel, rapid multiplexed molecular platforms represents a new opportunity for rapidly targeted antimicrobial therapy to improve patient outcomes and facilitate antibiotic stewardship. In this article we review the currently available testing platforms and discuss the potential benefits and pitfalls of rapid testing in pneumonia. url: https://www.ncbi.nlm.nih.gov/pubmed/31809764/ doi: 10.1016/j.jinf.2019.11.021 id: cord-347289-3yi5tz04 author: Poon, L. . C. title: ISUOG Interim Guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium: information for healthcare professionals – an update date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32356590/ doi: 10.1002/uog.22061 id: cord-336268-azgswke8 author: Porcel-Vazquez, Juan A. title: Usefulness of PCR Screening in the Initial Triage of Trauma Patients During COVID-19 Pandemic date: 2020-07-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Hospitals worldwide have postponed all nonessential surgery during the COVID-19 pandemic, but non-COVID-19 patients are still in urgent need of care. Uncertainty about a patient's COVID-19 status risks infecting health care workers and non-COVID-19 inpatients. We evaluated the use of quantitative reverse transcription polymerase chain reaction (RT-qPCR) screening for COVID-19 on admission for all patients with fractures. METHODS: We conducted a retrospective cohort study of patients older than 18 years admitted with low-energy fractures who were tested by RT-qPCR for SARS-CoV-2 at any time during hospitalization. Two periods based on the applied testing protocol were defined. During the first period, patients were only tested because of epidemiological criteria or clinical suspicion based on fever, respiratory symptoms, or radiological findings. In the second period, all patients admitted for fracture treatment were screened by RT-qPCR. RESULTS: We identified 15 patients in the first period and 42 in the second. In total, 9 (15.8%) patients without clinical or radiological findings tested positive at any moment. Five (33.3%) patients tested positive postoperatively in the first period and 3 (7.1%) in the second period (P = 0.02). For clinically unsuspected patients, postoperative positive detection went from 3 of 15 (20%) during the first period to 2 of 42 (4.8%) in the second (P = 0.11). Clinical symptoms demonstrated high specificity (92.1%) but poor sensitivity (52.6%) for infection detection. CONCLUSIONS: Symptom-based screening for COVID-19 has shown to be specific but not sensitive. Negative clinical symptoms do not rule out infection. Protocols and separated areas are necessary to treat infected patients. RT-qPCR testing on admission helps minimize the risk of nosocomial and occupational infection. LEVEL OF EVIDENCE: Level IV, retrospective cohort study. See Instructions for Authors for a complete description of levels of evidence. url: https://www.ncbi.nlm.nih.gov/pubmed/32675713/ doi: 10.1097/bot.0000000000001903 id: cord-314106-r3axl3w1 author: Porembskaya, Olga title: Pulmonary Artery Thrombosis: A Diagnosis That Strives for Its Independence date: 2020-07-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: According to a widespread theory, thrombotic masses are not formed in the pulmonary artery (PA) but result from migration of blood clots from the venous system. This concept has prevailed in clinical practice for more than a century. However, a new technologic era has brought forth more diagnostic possibilities, and it has been shown that thrombotic masses in the PA could, in many cases, be found without any obvious source of emboli. Chronic obstructive pulmonary disease, asthma, sickle cell anemia, emergency and elective surgery, viral pneumonia, and other conditions could be complicated by PA thrombosis development without concomitant deep vein thrombosis (DVT). Different pathologies have different causes for local PA thrombotic process. As evidenced by experimental results and clinical observations, endothelial and platelet activation are the crucial mechanisms of this process. Endothelial dysfunction can impair antithrombotic function of the arterial wall through downregulation of endothelial nitric oxide synthase (eNOS) or via stimulation of adhesion receptor expression. Hypoxia, proinflammatory cytokines, or genetic mutations may underlie the procoagulant phenotype of the PA endothelium. Both endotheliocytes and platelets could be activated by protease mediated receptor (PAR)- and receptors for advanced glycation end (RAGE)-dependent mechanisms. Hypoxia, in particular induced by high altitudes, could play a role in thrombotic complications as a trigger of platelet activity. In this review, we discuss potential mechanisms of PA thrombosis in situ. url: https://doi.org/10.3390/ijms21145086 doi: 10.3390/ijms21145086 id: cord-000268-480d3yfv author: Porfyridis, Ilias title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date: 2010-09-29 words: 4276.0 sentences: 222.0 pages: flesch: 45.0 cache: ./cache/cord-000268-480d3yfv.txt txt: ./txt/cord-000268-480d3yfv.txt summary: title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study The aim of the present study was to define whether expression of TREM-1 on cell membranes of neutrophils (nTREM-1), of monocytes (mTREM-1) and serum sTREM-1 may help in the diagnosis of acute bacterial infections for patients admitted with a new pulmonary infiltrate or pleural effusion. In conclusion, the presented results indicate that serum sTREM-1 and expression of TREM-1 on neutrophils and monocytes may serve as markers of CAP in patients with pulmonary infiltrates. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis Prognosis of community acquired pneumonia(CAP): value of triggering receptor expressed on myeloid cells-1 (TREM-1) and other mediators of the inflammatory response Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU abstract: BACKGROUND: Differential diagnosis of patients with lung infiltrates remains a challenge. Triggering receptor expressed on myeloid cells (TREM)-1 is a neutrophil and monocyte receptor up-regulated during infection. The aim of this study was to evaluate the diagnostic accuracy of TREM-1 and of C-reactive protein (CRP) from patients with lung infiltrates to discern community acquired lung infections. METHODS: 68 patients admitted to a medical ward with acute respiratory illness were enrolled in the study. Neutrophil and monocyte TREM-1 expression were measured by flow cytometry, sTREM-1 by an enzyme immunoassay and C-reactive protein by nephelometry. Clinical pulmonary infection score was recorded. RESULTS: 34 patients were diagnosed with bacterial community acquired pneumonia (group A) and 34 with non-bacterial pulmonary disease (group B). Median serum TREM-1 concentration was 102.09 pg/ml in group A and lower than 15.10 pg/ml (p < 0.0001) in group B. Mean±SE neutrophil TREM-1 expression was 4.67 ± 0.53 MFI in group A and 2.64 ± 0.25 MFI (p = 0.001) in group B. Monocyte TREM-1 expression was 4.2 ± 0.42 MFI in group A and 2.64 ± 0.35 MFI (p = 0.007) in group B and mean±SE CRP was 18.03 ± 2 mg/ml in group A and 7.1 ± 1.54 mg/ml (p < 0.001) in group B. A cut-off of 19.53 pg/ml of sTREM-1 with sensitivity 82.6% and specificity 63% to discriminate between infectious and non-infectious pulmonary infiltrates was found. sTREM-1 at admission greater than 180 pg/ml was accompanied with unfavourable outcome. CONCLUSION: TREM-1 myeloid expression and sTREM-1 are reliable markers of bacterial infection among patients with pulmonary infiltrates; sTREM-1 is a predictor of final outcome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955686/ doi: 10.1186/1471-2334-10-286 id: cord-349561-4mkiwg9k author: Porta, Alessandra Della title: Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians date: 2020-07-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Acute chloroquine and hydroxychloroquine toxicity is characterized by a combination of direct cardiovascular effects and electrolyte derangements with resultant dysrhythmias and is associated with significant morbidity and mortality. OBJECTIVE: This review describes acute chloroquine and hydroxychloroquine toxicity, outlines the complex pathophysiologic derangements, and addresses the emergency department (ED) management of this patient population. DISCUSSION: Chloroquine and hydroxychloroquine are aminoquinoline derivatives widely used in the treatment of rheumatologic diseases including systemic lupus erythematosus and rheumatoid arthritis as well as for malaria prophylaxis. In early 2020, anecdotal reports and preliminary data suggested utility of hydroxychloroquine in attenuating viral loads and symptoms in patients with SARS-CoV-2 infection. Aminoquinoline drugs pose unique and significant toxicological risks, both during their intended use as well as in unsupervised settings by laypersons. The therapeutic range for chloroquine is narrow. Acute severe toxicity is associated with 10–30% mortality owing to a combination of direct cardiovascular effects and electrolyte derangements with resultant dysrhythmias. Treatment in the ED is focused on decontamination, stabilization of cardiac dysrhythmias, hemodynamic support, electrolyte correction, and seizure prevention. CONCLUSIONS: An understanding of the pathophysiology of acute chloroquine and hydroxychloroquine toxicity and available emergency treatments can assist emergency clinicians in reducing the immediate morbidity and mortality associated with this disease. url: https://www.sciencedirect.com/science/article/pii/S0735675720306252?v=s5 doi: 10.1016/j.ajem.2020.07.030 id: cord-308002-abgv87e4 author: Porta, Camillo title: Editorial debate: Challenges an oncologist has to face during the SARS-CoV-2 pandemic within a universal healthcare system date: 2020-05-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1136/esmoopen-2020-000790 doi: 10.1136/esmoopen-2020-000790 id: cord-342930-f7cw2ca6 author: Portincasa, Piero title: Hepatic consequences of COVID-19 infection. Lapping or biting? date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The outbreak of coronavirus disease 2019 (COVID-19) starting last December in China placed emphasis on liver involvement during infection. This review discusses the underlying mechanisms linking COVID-19 to liver dysfunction, according to recent available information, while waiting further studies. The manifestations of liver damage are usually mild (moderately elevated serum aspartate aminotransferase activities), and generally asymptomatic. Few patients can still develop severe liver problems, and therapeutic options can be limited. Liver dysfunction may affect about one-third of the patients, with prevalence greater in men than women, and in elderly. Mechanisms of damage are complex and include direct cholangiocyte damage and other coexisting conditions such as the use of antiviral drugs, systemic inflammatory response, respiratory distress syndrome-induced hypoxia, sepsis, and multiple organ dysfunction. During new COVID-19 infections, liver injury may be observed. If liver involvement appears during COVID-19 infection, however, attention is required. This is particularly true if patients are older or have a pre-existing history of liver diseases. During COVID-19 infection, the onset of liver damage impairs the prognosis, and hospital stay is longer. url: https://doi.org/10.1016/j.ejim.2020.05.035 doi: 10.1016/j.ejim.2020.05.035 id: cord-304949-mf3utolt author: Porzio, Giampiero title: Home Care for Cancer Patients During COVID-19 Pandemic: The Double Triage Protocol date: 2020-03-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patients with cancer have an increased risk of developing severe forms of coronavirus disease 2019, and patients with advanced cancer who are followed at home represent a particularly frail population. Although with substantial differences, the challenges that cancer care professionals have to face during a pandemic are quite similar to those posed by natural disasters. We have already managed the oncological home care service in L’Aquila (middle Italy) after the 2009 earthquake. With this letter, we want to share the procedures and tools that we have started using at the home care service of the Tuscany Tumor Association during the coronavirus disease 2019 pandemic. url: https://www.sciencedirect.com/science/article/pii/S088539242030172X doi: 10.1016/j.jpainsymman.2020.03.021 id: cord-286227-foeb0g7u author: Potekaev, Nikolai N. title: Clinical characteristics of dermatologic manifestations of COVID‐19 infection: case series of 15 patients, review of literature, and proposed etiological classification date: 2020-07-03 words: 1102.0 sentences: 73.0 pages: flesch: 46.0 cache: ./cache/cord-286227-foeb0g7u.txt txt: ./txt/cord-286227-foeb0g7u.txt summary: A 59-year-old male patient presented with fever of 39°C and a rash of the lower extremities in combination with hemorrhagic elements which were consistent with polymorphic cutaneous vasculitis ( Fig. 3a ,b). A 47-year-old female patient with COVID-19 pneumonia developed acral urticarial highly pruritic rash on upper and lower extremities 5 days after the laboratory diagnosis (Fig. 7a, b ). A 71-year-old male patient, 2 weeks prior to our examination, developed papulovesicular eruptions while having escalating clinical symptoms of COVID-19 infection (fever, weakness, cough, shortness of breath) (Fig. 8a,b) . A 46-year-old female patient with confirmed COVID-19 infection and bilateral pneumonia presented with papulovesicular elements in the chest area (Fig. 9) . A 56-year-old male patient with COVID-19 infection presented with skin lesions, also called "bilateral inguinal purple rash." Large pink-red plaques were observed in both inguinal folds with a transition to the inner thighs, with a brownish tint and abundance of follicular papules along the periphery (Fig. 13) . abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32621287/ doi: 10.1111/ijd.15030 id: cord-004515-x22q1f21 author: Pottecher, Julien title: Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients date: 2020-03-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Acute respiratory distress syndrome continues to drive significant morbidity and mortality after severe trauma. The incidence of trauma-induced, moderate-to-severe hypoxaemia, according to the Berlin definition, could be as high as 45%. Its pathophysiology includes the release of damage-associated molecular patterns (DAMPs), which propagate tissue injuries by triggering neutrophil extracellular traps (NETs). NETs include a DNA backbone coated with cytoplasmic proteins, which drive pulmonary cytotoxic effects. The structure of NETs and many DAMPs includes double-stranded DNA, which prevents their neutralization by plasma. Dornase alfa is a US Food and Drug Administration-approved recombinant DNase, which cleaves extracellular DNA and may therefore break up the backbone of NETs and DAMPs. Aerosolized dornase alfa was shown to reduce trauma-induced lung injury in experimental models and to improve arterial oxygenation in ventilated patients. METHODS: TRAUMADORNASE will be an institution-led, multicentre, double-blinded, placebo-controlled randomized trial in ventilated trauma patients. The primary trial objective is to demonstrate a reduction in the incidence of moderate-to-severe hypoxaemia in severe trauma patients during the first 7 days from 45% to 30% by providing aerosolized dornase alfa as compared to placebo. The secondary objectives are to demonstrate an improvement in lung function and a reduction in morbidity and mortality. Randomization of 250 patients per treatment arm will be carried out through a secure, web-based system. Statistical analyses will include a descriptive step and an inferential step using fully Bayesian techniques. The study was approved by both the Agence Nationale de la Sécurité du Médicament et des Produits de Santé (ANSM, on 5 October 2018) and a National Institutional Review Board (CPP, on 6 November 2018). Participant recruitment began in March 2019. Results will be published in international peer-reviewed medical journals. DISCUSSION: If early administration of inhaled dornase alfa actually reduces the incidence of moderate-to-severe hypoxaemia in patients with severe trauma, this new therapeutic strategy may be easily implemented in many clinical trauma care settings. This treatment may facilitate ventilator weaning, reduce the burden of trauma-induced lung inflammation and facilitate recovery and rehabilitation in severe trauma patients. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03368092. Registered on 11 December 2017. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079402/ doi: 10.1186/s13063-020-4141-6 id: cord-307287-zpq6byml author: Poulsen, Nadia Nicholine title: Cyclosporine and COVID‐19: Risk or Favorable? date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 (COVID‐19) pandemic is declared a global health emergency. COVID‐19 is triggered by a novel coronavirus: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV2). Baseline characteristics of admitted patients with COVID‐19 show that adiposity, diabetes and hypertension are risk factors for developing severe disease, but so far immunosuppressed patients that are listed as high‐risk patients have not been more susceptible to severe COVID‐19 than the rest of the population. Multiple clinical trials are currently being conducted, which hopefully can identify more drugs that can lower mortality, morbidity and burden on the society. Several independent studies have convincingly shown that cyclosporine inhibit replication of several different coronaviruses in vitro. The cyclosporine‐analog Alisporivir has recently been shown to inhibit SARS‐CoV2 in vitro. These findings are intriguing, although there is no clinical evidence for a protective effect to reduce the likelihood of severe COVID‐19 or to treat the immune storm or adult respiratory distress syndrome (ARDS) that often causes severe morbidity. Here, we review the putative link between COVID‐19 and cyclosporine, while we await more robust clinical data. url: https://doi.org/10.1111/ajt.16250 doi: 10.1111/ajt.16250 id: cord-265053-x70501t3 author: Pourhomayoun, Mohammad title: Predicting Mortality Risk in Patients with COVID-19 Using Artificial Intelligence to Help Medical Decision-Making date: 2020-04-01 words: 1855.0 sentences: 105.0 pages: flesch: 48.0 cache: ./cache/cord-265053-x70501t3.txt txt: ./txt/cord-265053-x70501t3.txt summary: In the wake of COVID-19 disease, caused by the SARS-CoV-2 virus, we designed and developed a predictive model based on Artificial Intelligence (AI) and Machine Learning algorithms to determine the health risk and predict the mortality risk of patients with COVID-19. We used several machine learning algorithms including Support Vector Machine (SVM), Artificial Neural Networks, Random Forest, Decision Tree, Logistic Regression, and K-Nearest Neighbor (KNN) to predict the mortality rate in patients with COVID-19. In this study, we proposed a data-driven predictive analytics algorithm based on Artificial Intelligence (AI) and machine learning to determine the health risk and predict the mortality risk of patients with COVID-19. After preprocessing the data, we use machine learning algorithms to develop a predictive model to classify the data, predict the medical condition, and calculate the probability and risk of mortality. Table 1 demonstrates the prediction accuracy for predicting mortality in patients with COVID-19 using 10-fold cross-validation for various machine learning algorithms. abstract: In the wake of COVID-19 disease, caused by the SARS-CoV-2 virus, we designed and developed a predictive model based on Artificial Intelligence (AI) and Machine Learning algorithms to determine the health risk and predict the mortality risk of patients with COVID-19. In this study, we used documented data of 117,000 patients world-wide with laboratory-confirmed COVID-19. This study proposes an AI model to help hospitals and medical facilities decide who needs to get attention first, who has higher priority to be hospitalized, triage patients when the system is overwhelmed by overcrowding, and eliminate delays in providing the necessary care. The results demonstrate 93% overall accuracy in predicting the mortality rate. We used several machine learning algorithms including Support Vector Machine (SVM), Artificial Neural Networks, Random Forest, Decision Tree, Logistic Regression, and K-Nearest Neighbor (KNN) to predict the mortality rate in patients with COVID-19. In this study, the most alarming symptoms and features were also identified. Finally, we used a separate dataset of COVID-19 patients to evaluate our developed model accuracy, and used confusion matrix to make an in-depth analysis of our classifiers and calculate the sensitivity and specificity of our model. url: https://doi.org/10.1101/2020.03.30.20047308 doi: 10.1101/2020.03.30.20047308 id: cord-030918-0w327dgj author: Praena Crespo, Manuel title: Patient-centered primary care pediatrics. Is a paradigm change needed?() date: 2020-08-27 words: 1315.0 sentences: 56.0 pages: flesch: 49.0 cache: ./cache/cord-030918-0w327dgj.txt txt: ./txt/cord-030918-0w327dgj.txt summary: At present, the functional organization of paediatric care in PCTs includes health prevention and promotion activities through healthy child (HC) and school-based health programmes, on-demand visits for management of acute diseases, scheduled appointments for follow-up of chronic diseases and coordination of care delivery by different providers: nurses, midwives, dentists, physical therapists, psychologists, social workers and family physicians. Another high-priority organizational change is the participation of paediatric nurses in the care of the paediatric population, both in the form of on-demand nursing visits for follow-up of patients with acute diseases and, especially, the management of patients with SHCNs through scheduled nursing visits for health education and follow-up of patients with asthma, obesity, diabetes and other chronic diseases requiring nursing care and healthy child programme services. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450238/ doi: 10.1016/j.anpede.2020.08.002 id: cord-353004-ocnp758o author: Prakash, Lakshmanan title: COVID-19 in the operating room: a review of evolving safety protocols date: 2020-07-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The COVID-19 pandemic has already infected more than 3 million people across the world. As the healthworkers man the frontlines, the best practices model is continuously evolving as literature concerning the Coronavirus develops. METHODS: A systematic review of the available literature was performed using the keyword terms “COVID-19”, “Coronavirus”, “surgeon”, “health-care workers”, “protection” and “Orthopaedic Surgery”. All peer-reviewed articles we could find were considered. Randomized controlled trials (RCTs), prospective trials and retrospective studies, as well as reviews and case reports, were included in this systematic review. RESULTS: Even though surgical specialties including orthopedics are on the relative sidelines of the management of this pandemic but best practices models are inevitably developed for surgical specialties. The algorithm of postpone, delay, and operate only when life-threatening conditions exist is going to be useful up to a point. CONCLUSION: The surgical staff needs to keep abreast of the latest literature concerning safety measures to be taken during surgical procedures. Review articles can go some distance in helping in this educational process. This knowledge must evolve as new information comes to light. url: https://doi.org/10.1186/s13037-020-00254-6 doi: 10.1186/s13037-020-00254-6 id: cord-252368-njlo6g78 author: Prasad, Aman title: Optimizing your telemedicine visit during the COVID‐19 pandemic: Practice guidelines for patients with head and neck cancer date: 2020-04-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID‐19 epidemic has resulted in many hospitals and practices to cancel in‐person outpatient clinic visits, where head and neck patients receive their critical longitudinal care. Out of necessity, most practices have been encouraged to use telemedicine as a method to maintain a continuum of care with their patients. As a result, the prevalence of telemedicine has grown rapidly during this pandemic, without allowing the physicians and patients to be adequately educated on how best to utilize the services. There is a steep learning curve as we have learned, and our goal is to provide guidelines for both patients and physicians, as well as a valuable patient handout in preparation for their visit. url: https://www.ncbi.nlm.nih.gov/pubmed/32343458/ doi: 10.1002/hed.26197 id: cord-352678-8f2ygul2 author: Prasad, Ashish title: Single Virus Targeting Multiple Organs: What We Know and Where We Are Heading? date: 2020-08-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 caused by SARS-CoV-2 has already infected more than 6. 3 million people worldwide as of 1st June 2020 and caused a global medical emergency. Healthcare professionals have been struggling to devise appropriate therapeutic strategies against the virus mainly due to the diverse range of symptoms and multiple-organ failure in infected patients. Several broad-spectrum antiviral drugs are being used for treatment; however, there is yet no specific drug or vaccine against the virus. Multiple-organ failure due to hyperactivity of the immune system resulting in cytokine storms is a major reason for death among the 5% critically ill patients. In this article, we have discussed the damage caused by COVID-19 on different organs of the human body. url: https://www.ncbi.nlm.nih.gov/pubmed/32850890/ doi: 10.3389/fmed.2020.00370 id: cord-292485-vk5xy3zn author: Prasad, Narayan title: The adverse effect of COVID pandemic on the care of patients with kidney diseases in India date: 2020-07-06 words: 3490.0 sentences: 180.0 pages: flesch: 53.0 cache: ./cache/cord-292485-vk5xy3zn.txt txt: ./txt/cord-292485-vk5xy3zn.txt summary: We aimed to analyze the effect of lockdown imposed due to COVID-19 pandemic on the care of patients with kidney diseases in India. METHODS: We surveyed 19 major hospitals (8 in public and 11 in private sector) to determine the effect of lockdown on the care of patients with kidney disease, including those on dialysis after the first 3 weeks of lockdown. CONCLUSION: Lack of preparedness before lockdown resulted in an interruption in health care services and posed an immediate adverse effect on the outcome of dialysis and kidney disease patients in India. This survey clearly demonstrates the impact of the COVID-19 pandemic and lockdown on the care of patients with kidney diseases in India, a low-middle income country. In many private hospitals, services were affected due to lockdown restrictions, lack of internal protocols to handle the pandemic, fear of infection to medical staff, and an unwillingness to risk the business from non-COVID patients (22). abstract: INTRODUCTION: The Coronavirus disease-19 (COVID-19) pandemic has affected the care of patients with non-communicable diseases, including those suffering from kidney-related ailments. Many parts of the world, including India, adopted lockdown to curb community transmission of disease. The lockdown affected transportation, access to healthcare facilities, availability of medicines, and consumables as well as out and inpatient services. We aimed to analyze the effect of lockdown imposed due to COVID-19 pandemic on the care of patients with kidney diseases in India. METHODS: We surveyed 19 major hospitals (8 in public and 11 in private sector) to determine the effect of lockdown on the care of patients with kidney disease, including those on dialysis after the first 3 weeks of lockdown. RESULTS: The total number of dialysis patients in these centres came down from 2517 to 2404. About 710(28.2%) of patients missed one or more dialysis sessions, 69 (2.74%) required emergency dialysis sessions, 104 (4.13%) stopped reporting for dialysis, and 9 (0.36%) were confirmed to have died. Outpatient attendance in the surveyed hospital came down by 92.3%, and inpatient service reduced by 61%. Tele-consultation was started but accessed by only a small number of patients. CONCLUSION: Lack of preparedness before lockdown resulted in an interruption in health care services and posed an immediate adverse effect on the outcome of dialysis and kidney disease patients in India. The long-term impact on the health of patients with less severe forms of kidney disease remains unknown. url: https://www.sciencedirect.com/science/article/pii/S2468024920313577?v=s5 doi: 10.1016/j.ekir.2020.06.034 id: cord-254148-wc762p6v author: Prell, Tino title: Recommendations for Standards of Network Care for Patients with Parkinson’s Disease in Germany date: 2020-05-13 words: 5349.0 sentences: 267.0 pages: flesch: 41.0 cache: ./cache/cord-254148-wc762p6v.txt txt: ./txt/cord-254148-wc762p6v.txt summary: title: Recommendations for Standards of Network Care for Patients with Parkinson''s Disease in Germany Thus, one recommendation for standard of care in the initial phase of the disease course is physician awareness of the first signs of PD (which could be achieved with better information and secondary prevention standards in the network) and early referral of patients to a movement disorder specialist (which could be achieved by specific disease management programmes). For these patients, at the border between inpatient and outpatient care and the need for sophisticated treatment strategies, the new comprehensive, individual, and interdisciplinary concept of a PD day clinic has proven to be effective [25] . In general, a neurologist should be responsible for long-term medical care of patients with PD, and movement disorder specialists should be involved when there is a special issue. abstract: Although our understanding of Parkinson’s disease (PD) has improved and effective treatments are available, caring for people with PD remains a challenge. The large heterogeneity in terms of motor symptoms, nonmotor symptoms, and disease progression makes tailored individual therapy and individual timing of treatment necessary. On the other hand, only limited resources are available for a growing number of patients, and the high quality of treatment cannot be guaranteed across the board. At this point, networks can help to make better use of resources and improve care. The working group PD Networks and Integrated Care, part of the German Parkinson Society, is entrusted to convene clinicians, therapists, nurses, researchers, and patients to promote the development of PD networks. This article summarizes the work carried out by the working group PD Networks and Integrated Care in the development of standards of network care for patients with PD in Germany. url: https://doi.org/10.3390/jcm9051455 doi: 10.3390/jcm9051455 id: cord-307690-1qqyixun author: Preti, Emanuele title: Personality Disorders in Time of Pandemic date: 2020-11-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: We report evidence on the negative psychological effects of pandemics in people with personality disorders (PDs) and on the role of personality pathology in compliance with mitigation-related behaviors. Considering the paucity of studies, after a description of the main features of PDs, on the basis of the current literature on pandemic and quarantine mental health impact, we trace some clinical hypotheses. RECENT FINDINGS: Paranoid traits and detachment (cluster A) might lead to worse psychological outcomes. Cluster B patients may show more intense stress-related reactions and react strongly to social distancing, especially considering borderline personality disorder. Cluster C patients might be particularly prone to anxiety and stress due to fear of contagion and may be less flexible in adaptation to new routines. Evidence on compliance with mitigation measures is mixed, with lower compliance in cluster B patients and higher in cluster C ones. SUMMARY: We suggest that PD patients might be particularly affected by pandemics. Furthermore, they might react differently, according to their main diagnosis. Similarly, compliance with mitigation measures may differ according to specific PDs. Our results should be considered as a starting point to reflect on therapeutic strategies to be adopted in the post-COVID-19 situation. url: https://doi.org/10.1007/s11920-020-01204-w doi: 10.1007/s11920-020-01204-w id: cord-296694-2js639bk author: Price, Laura C title: Thrombosis and COVID-19 pneumonia: the clot thickens! date: 2020-06-18 words: 2396.0 sentences: 120.0 pages: flesch: 38.0 cache: ./cache/cord-296694-2js639bk.txt txt: ./txt/cord-296694-2js639bk.txt summary: The true prevalence of thrombosis associated with COVID-19 infection is unknown, as most studies to date do not include systematic and comprehensive investigation protocols. Two recent Dutch studies have reported cumulative incidences of thrombotic events between 48 and 49% respectively in their ICUs in patients with COVID-19 pneumonia [10, 11] . refine this further by describing a 50% cumulative incidence of pulmonary embolism (PE), diagnosed by CT-pulmonary angiogram (PA), in COVID-19 patients admitted to ICU in two hospitals of the University of Paris (ERJ ref Bompard). In addition to ACE2 mediated SARS-CoV-2 viral entry, recent reports of affinity of the SARS-CoV-2 spike protein and CD147, a membrane glycoprotein and extracellular matrix metalloproteinase inducer expressed on a variety of haematopoietic cell lines, suggest another potentially novel mechanism of thrombosis and inflammation in the arterial and venous circulations [27] . High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients abstract: Pulmonary thrombosis appears to be common in Covid-19 pneumonia and takes two forms, proximal pulmonary emboli and/or distal thrombosis. We hypothesise mechanisms and discuss clinical implications. url: https://doi.org/10.1183/13993003.01608-2020 doi: 10.1183/13993003.01608-2020 id: cord-002240-38aabxh1 author: Prina, Elena title: New aspects in the management of pneumonia date: 2016-10-01 words: 4832.0 sentences: 216.0 pages: flesch: 35.0 cache: ./cache/cord-002240-38aabxh1.txt txt: ./txt/cord-002240-38aabxh1.txt summary: The administration of intravenous immunoglobulins seems to reinforce the immune response to the infection in particular in patients with inadequate levels of antibodies and when an enriched IgM preparation has been used; however, more studies are needed to determinate their impact on outcome and to define the population that will receive more benefit. Despite the use of early and appropriate antibiotic treatment, mortality related to community-acquired pneumonia (CAP) is still high [1] , especially in patients with severe disease. In contrast, another meta-analysis [25] demonstrated a reduction in all causes of mortality in patients receiving corticosteroids (12 trials, 1974 In conclusion, all these studies confirm that the use of corticosteroids in CAP is associated with the following benefits: reduced length of hospital stay, reduced time to clinical stability, and prevention of ARDS. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial abstract: Despite improvements in the management of community-acquired pneumonia (CAP), morbidity and mortality are still high, especially in patients with more severe disease. Early and appropriate antibiotics remain the cornerstone in the treatment of CAP. However, two aspects seem to contribute to a worse outcome: an uncontrolled inflammatory reaction and an inadequate immune response. Adjuvant treatments, such as corticosteroids and intravenous immunoglobulins, have been proposed to counterbalance these effects. The use of corticosteroids in patients with severe CAP and a strong inflammatory reaction can reduce the time to clinical stability, the risk of treatment failure, and the risk of progression to acute respiratory distress syndrome. The administration of intravenous immunoglobulins seems to reinforce the immune response to the infection in particular in patients with inadequate levels of antibodies and when an enriched IgM preparation has been used; however, more studies are needed to determinate their impact on outcome and to define the population that will receive more benefit. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045574/ doi: 10.1186/s13054-016-1442-y id: cord-276288-upv2o8f6 author: Prior, Sarah Jane title: Person-centred data collection methods to embed the authentic voice of people who experience health challenges date: 2020-07-21 words: 3680.0 sentences: 189.0 pages: flesch: 42.0 cache: ./cache/cord-276288-upv2o8f6.txt txt: ./txt/cord-276288-upv2o8f6.txt summary: The patient or consumer voice in healthcare has evolved from an aspiration to becoming an expectation, which in some developed countries is respected by inclusion in nationally auditable standards (Australian Commission on Safety and Quality in Health-Care. Understanding the characteristics of the population is key to ensuring appropriate representation of consumers in person-centred or patient involvement research methods. 4 Direct engagement of patients and other consumers in research and health service improvement activities requires careful methodological planning around desirability and feasibility and the practical implications for the involvement of patients and consumer as participants. 5 The following examples of person-centred research methods enable the authentic voice of individuals who experience health challenges to be collected. 11 Codesign using focus groups is an opportunity for patients and other consumers to consider and discuss their experiences within healthcare systems and services in a collaborative, participatory setting. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32699082/ doi: 10.1136/bmjoq-2020-000912 id: cord-282610-zim7nond author: Proal, Amy title: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity date: 2018-12-04 words: 12428.0 sentences: 723.0 pages: flesch: 38.0 cache: ./cache/cord-282610-zim7nond.txt txt: ./txt/cord-282610-zim7nond.txt summary: title: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity Intracellular pathogens, including many associated with ME/CFS, drive microbiome dysbiosis by directly interfering with human transcription, translation, and DNA repair processes. The gut microbiome can initiate and promote colorectal cancer at all stages of tumorigenesis by acting as an inducer of DNA damage, generating epigenetic changes, regulating cell growth, and modulating host immune responses (80) . If ME/CFS is driven by successive infection, treatments that support or activate the human immune system could improve microbiome health by allowing patients to better target persistent pathogens. Antibodies and/or clonal T cells identified in patients with ME/CFS are likely activated in response to many of these persistent microbiome pathogens. In ME/CFS, the immune response, metabolism, central nervous system, and human gene expression are all linked by the activity of the microbiome and its associated proteins/metabolites. abstract: The illness ME/CFS has been repeatedly tied to infectious agents such as Epstein Barr Virus. Expanding research on the human microbiome now allows ME/CFS-associated pathogens to be studied as interacting members of human microbiome communities. Humans harbor these vast ecosystems of bacteria, viruses and fungi in nearly all tissue and blood. Most well-studied inflammatory conditions are tied to dysbiosis or imbalance of the human microbiome. While gut microbiome dysbiosis has been identified in ME/CFS, microbes and viruses outside the gut can also contribute to the illness. Pathobionts, and their associated proteins/metabolites, often control human metabolism and gene expression in a manner that pushes the body toward a state of illness. Intracellular pathogens, including many associated with ME/CFS, drive microbiome dysbiosis by directly interfering with human transcription, translation, and DNA repair processes. Molecular mimicry between host and pathogen proteins/metabolites further complicates this interference. Other human pathogens disable mitochondria or dysregulate host nervous system signaling. Antibodies and/or clonal T cells identified in patients with ME/CFS are likely activated in response to these persistent microbiome pathogens. Different human pathogens have evolved similar survival mechanisms to disable the host immune response and host metabolic pathways. The metabolic dysfunction driven by these organisms can result in similar clusters of inflammatory symptoms. ME/CFS may be driven by this pathogen-induced dysfunction, with the nature of dysbiosis and symptom presentation varying based on a patient's unique infectious and environmental history. Under such conditions, patients would benefit from treatments that support the human immune system in an effort to reverse the infectious disease process. url: https://doi.org/10.3389/fped.2018.00373 doi: 10.3389/fped.2018.00373 id: cord-345044-2fez1gu0 author: Proenca‐Modena, José Luiz title: Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children date: 2019-03-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The role of human adenovirus (HAdV) infection in different acute diseases, such as febrile exudative tonsillitis, conjunctivitis, and pharyngoconjunctival fever is well established. However, the relationships, if any, of HAdV persistence and reactivation in the development of the chronic adenotonsillar disease is not fully understood. The present paper reports a 3‐year cross‐sectional hospital‐based study aimed at detecting and quantifying HAdV DNA and mRNA of the HAdV hexon gene in adenoid and palatine tonsil tissues and nasopharyngeal secretions (NPS) from patients with adenotonsillar hypertrophy or recurrent adenotonsillitis. HAdV C, B, and E were detectable in nearly 50% of the patients, with no association with the severity of airway obstruction, nor with the presence of recurrent tonsillitis, sleep apnea or otitis media with effusion (OME). Despite the higher rates of respiratory viral coinfections in patients with HAdV, the presence of other viruses, including DNA and RNA viruses, had no association with HAdV replication or shedding in secretions. Higher HAdV loads in adenoids showed a significant positive correlation with the presence of sleep apnea and the absence of OME. Although this study indicates that a significant proportion (~85%) of individuals with chronic adenotonsillar diseases have persistent nonproductive HAdV infection, including those by HAdV C, B, and E, epithelial and subepithelial cells in tonsils seem to be critical for HAdV C production and shedding in NPS in some patients, since viral antigen was detected in these regions by immunohistochemistry in four patients, all of which were also positive for HAdV mRNA detection. url: https://www.ncbi.nlm.nih.gov/pubmed/30815882/ doi: 10.1002/jmv.25441 id: cord-310240-otf9ruvj author: Prohaska, Stefanie title: Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy date: 2018-02-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Acute respiratory distress syndrome (ARDS) is associated with high mortality rates. ARDS patients suffer from severe hypoxemia, and extracorporeal membrane oxygenation (ECMO) therapy may be necessary to ensure oxygenation. ARDS has various etiologies, including trauma, ischemia-reperfusion injury or infections of various origins, and the associated immunological responses may vary. To support the immunological response in this patient collective, we used intravenous IgM immunoglobulin therapy to enhance the likelihood of pulmonary recovery. METHODS: ARDS patients admitted to the intensive care unit (ICU) who were placed on ECMO and treated with (IVIG group; n = 29) or without (control group; n = 28) intravenous IgM-enriched immunoglobulins for 3 days in the initial stages of ARDS were analyzed retrospectively. RESULTS: The baseline characteristics did not differ between the groups, although the IVIG group showed a significantly reduced oxygenation index compared to the control group. We found no differences in the length of ICU stay or ventilation parameters. We did not find a significant difference between the groups for the extent of inflammation or for overall survival. CONCLUSION: We conclude that administration of IgM-enriched immunoglobulins as an additional therapy did not have a beneficial effect in patients with severe ARDS requiring ECMO support. TRIAL REGISTRATION: Clinical Trials: NCT02961166; retrospectively registered. url: https://doi.org/10.1186/s40560-018-0278-8 doi: 10.1186/s40560-018-0278-8 id: cord-103807-x4hrwhkz author: Prokop, J. W. title: Viral Induced Genetics Revealed by Multi-Dimensional Precision Medicine Transcriptional Workflow date: 2020-04-06 words: 6843.0 sentences: 375.0 pages: flesch: 50.0 cache: ./cache/cord-103807-x4hrwhkz.txt txt: ./txt/cord-103807-x4hrwhkz.txt summary: Patients often present to the intensive care unit with broad phenotypes, including multiple organ dysfunction syndrome (MODS) resulting from infection, trauma, or other disease processes. Using multi-time point whole blood (cellular/acellular) total transcriptomics in 27 patients, we highlight the promise of simultaneously mapping viral/bacterial load, cell composition, tissue damage biomarkers, balance between syndromic biology vs. The power of RNA generated data likely is in its potential to effect therapeutic changes in individual patients with diverse clinical presentations, such as Multiple Organ Dysfunction Syndrome (MODS). Additional insights from the top mapped bacteria include normal flora elevation of Polynucleobacter necessarius and Bordetella parapertussis in patient 24 suggested to have issues in antigen processing and presentation (case study presented below for RNASEH2B), multiple Streptococcus strains (including pyogenes) identified in patients 11 and 5 that were culture positive, Pandoraea faecigallinarum in patient 10, and Cryobacterium arcticum in patient 10 day 0. abstract: Precision medicine requires the translation of basic biological understanding to medical insights, mainly applied to characterization of each unique patient. In many clinical settings, this requires tools that can be broadly used to identify pathology and risks. Patients often present to the intensive care unit with broad phenotypes, including multiple organ dysfunction syndrome (MODS) resulting from infection, trauma, or other disease processes. Etiology and outcomes are unique to individuals, making it difficult to cohort patients with MODS, but presenting a prime target for testing/developing tools for precision medicine. Using multi-time point whole blood (cellular/acellular) total transcriptomics in 27 patients, we highlight the promise of simultaneously mapping viral/bacterial load, cell composition, tissue damage biomarkers, balance between syndromic biology vs. environmental response, and unique biological insights in each patient using a single platform measurement. Integration of a transcriptome workflow yielded unexpected insights into the complex interplay between host genetics and viral/bacterial specific mechanisms, highlighted by a unique case of virally induced genetics (VIG) within one of these 27 patients. The power of RNAseq to study unique patient biology while investigating environmental contributions can be a critical tool moving forward for translational sciences applied to precision medicine. url: http://medrxiv.org/cgi/content/short/2020.04.01.20050054v1?rss=1 doi: 10.1101/2020.04.01.20050054 id: cord-343832-xg3swuzs author: Pugliese, Daniela title: The management of Inflammatory Bowel Diseases in the era of COVID-19 pandemic: when “non-urgent” does not mean “deferrable” date: 2020-06-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.dld.2020.05.053 doi: 10.1016/j.dld.2020.05.053 id: cord-312795-0e4esl2o author: Puig-Domingo, M. title: COVID-19 and endocrine diseases. A statement from the European Society of Endocrinology date: 2020-04-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s12020-020-02294-5 doi: 10.1007/s12020-020-02294-5 id: cord-323910-lms3xw4k author: Putman, Michael title: Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐analysis date: 2020-08-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Antirheumatic disease therapies have been used to treat coronavirus disease 2019 (COVID‐19) and its complications. We conducted a systematic review and meta‐analysis to describe the current evidence. METHODS: A search of published and preprint databases in all languages was performed. Included studies described one or more relevant clinical outcomes in five or more people who were infected with SARS‐CoV‐2 and were treated with antirheumatic disease therapy between 01/01/2019 and 05/29/2020. Pairs of reviewers screened articles and extracted data and assessed risk of bias. A meta‐analysis of effect sizes using the random‐effects models was performed when possible. RESULTS: The search identified 3,935 articles, of which 45 were included (4 randomized controlled trials, 29 cohort studies, and 12 case series). All studies evaluated hospitalized patients and 29 out of 45 had been published in a peer‐reviewed journal. In a meta‐analysis of three cohort studies with a low risk of bias, hydroxychloroquine use was not significantly associated with mortality (pooled hazard ratio (HR) 1.41, 95% confidence interval (CI) 0.83‐2.42). In a meta‐analysis of two cohort studies with some concerns/high risk of bias, anakinra use was associated with lower mortality (pooled HR 0.2, 95% CI 0.1‐0.4). Evidence was inconclusive with regard to other antirheumatic disease therapies and the majority of other studies had a high risk of bias. CONCLUSION: In this systematic review and meta‐analysis, hydroxychloroquine use was not associated with benefit or harm with regard to COVID‐19 mortality. The evidence supporting the effect of other antirheumatic disease therapies in COVID‐19 is currently inconclusive. url: https://www.ncbi.nlm.nih.gov/pubmed/32741139/ doi: 10.1002/art.41469 id: cord-266750-41gth6o0 author: Puzzitiello, Richard N. title: Inflammatory and Coagulative Considerations for the Management of Orthopaedic Trauma Patients With COVID-19: A Review of the Current Evidence and Our Surgical Experience date: 2020-05-14 words: 3742.0 sentences: 221.0 pages: flesch: 39.0 cache: ./cache/cord-266750-41gth6o0.txt txt: ./txt/cord-266750-41gth6o0.txt summary: A better understanding of this relationship can inform the development of evidencebased management strategies in these patients and limit admissions to overcrowded ICUs. To demonstrate and further define these developing theories on the coagulative and inflammatory risks associated with the surgical treatment of trauma patients with COVID-19, we will present an unexpected outcome on such a patient at our institution. In addition, the hypercoagulable state secondary to COVID-19 and the inflammatory load of intramedullary reaming, fat emboli, and pulmonary embolism resulted in a "second hit" that may have cumulatively pushed our patient past a "tipping point" and into respiratory failure (Fig. 4) . The level of cytokine response, hypercoagulability, and pulmonary dysfunction associated with the COVID-19 virus may predispose to a catastrophic "second hit" after even low-energy trauma. Careful consideration and risk/benefit analysis, including preoperative evaluation of systemic inflammation and respiratory status, is paramount in patients with COVID-19 presenting with orthopaedic trauma injuries. abstract: Mounting evidence suggests that the pathogenesis of coronavirus disease 2019 (COVID-19) involves a hyperinflammatory response predisposing patients to thromboembolic disease and acute respiratory distress. In the setting of severe blunt trauma, damaged tissues induce a local and systemic inflammatory response through similar pathways to COVID-19. As such, patients with COVID-19 sustaining orthopaedic trauma injuries may have an amplified response to the traumatic insult because of their baseline hyperinflammatory and hypercoagulable states. These patients may have compromised physiological reserve to withstand the insult of surgical intervention before reaching clinical instability. In this article, we review the current evidence regarding pathogenesis of COVID-19 and its implications on the management of orthopaedic trauma patients by discussing a case and the most recent literature. url: https://doi.org/10.1097/bot.0000000000001842 doi: 10.1097/bot.0000000000001842 id: cord-005697-l1zmrq4p author: Pène, Frédéric title: Is this critically ill patient immunocompromised? date: 2015-12-02 words: 1344.0 sentences: 67.0 pages: flesch: 29.0 cache: ./cache/cord-005697-l1zmrq4p.txt txt: ./txt/cord-005697-l1zmrq4p.txt summary: A subset of septic patients infected with highly virulent pathogens may die rapidly from refractory shock, disseminated intravascular coagulation, and intractable multiple organ failure as a result of hyper-cytokinemia and uncontrolled inflammatory response. However, with improvements in acute care and resuscitation therapies, this classical exuberant presentation is relatively rare nowadays, and the physician is more often challenged by a blunted clinical response to infection, with subtle findings including lethargy or depressed mental status, glucose intolerance and hyperglycemia, hypothermia, and/or a change in the white blood cell count or cell differential. In addition to overt immunosuppressive conditions (e.g., cancer and hematological malignancies, solid organ transplant, autoimmune and systemic diseases, HIV, use of immunosuppressive drugs), many septic patients commonly exhibit additional risk factors affecting immune status [3] . Regardless of underlying comorbidities and primary injuries responsible for ICU admission, a significant proportion of critically ill patients can reasonably be considered to be immunocompromised and at risk for ICU-acquired infections, especially if they develop overt signs of immunosuppression. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095223/ doi: 10.1007/s00134-015-4161-y id: cord-336614-u6alc6rs author: Pérez-Belmonte, Luis M. title: Differences between Clinical Protocols for the Treatment of Coronavirus Disease 2019 (COVID-19) in Andalusia, Spain date: 2020-09-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Our objective was to compare clinical protocols for the treatment of the novel coronavirus disease 2019 (COVID-19) among different hospitals in Andalusia, Spain. We reviewed the current COVID-19 protocols of the 15 largest hospitals in Andalusia. Antiviral treatment, empirical antibacterial agents, adjunctive therapies, anticoagulant treatment, supportive care, hospital organization, and discharge recommendations were analyzed. All protocols included were the latest updates as of July 2020. Hydroxychloroquine in monotherapy was the most frequent antiviral drug recommended for mild respiratory illness with clinical risk factors (33.3%). Combined hydroxychloroquine with azithromycin or lopinavir/ritonavir was found in 40% of protocols. The recommended treatment for patients with mild and moderate pneumonias was different antiviral combinations including hydroxychloroquine plus azithromycin (93.3%) or hydroxychloroquine plus lopinavir/ritonavir (79.9%). Different combinations of hydroxychloroquine and lopinavir/ritonavir (46.7%) and triple therapy with hydroxychloroquine, azithromycin, and lopinavir/ritonavir (40%) were the most recommended treatments for patients with severe pneumonia. There were five corticosteroid regimens, which used dexamethasone, methylprednisolone, or prednisone, with different doses and treatment durations. Anakinra was included in seven protocols with six different regimens. All protocols included prophylactic heparin and therapeutic doses for thromboembolism. Higher prophylactic doses of heparin for high-risk patients and therapeutic doses for patients in critical condition were included in 53.3% and 33.3% of protocols, respectively. This study showed that COVID-19 protocols varied widely in several aspects (antiviral treatment, corticosteroids, anakinra, and anticoagulation for high risk of thrombosis or critical situation). Rigorous randomized clinical trials on the proposed treatments are needed to provide consistent evidence. url: https://www.ncbi.nlm.nih.gov/pubmed/32961675/ doi: 10.3390/ijerph17186845 id: cord-340070-de7sfccy author: Pérez-Martinez, Antonio title: Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain date: 2020-08-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Limited information is available regarding SARS-CoV-2 infections in children with underlying diseases. A retrospective study of children less than 15 years old with primary or secondary immunosuppression infected with SARS-CoV-2 during March 2020 was performed. In this series, 8 immunocompromised patients with COVID-19 disease are reported, accounting for 15% of the positive cases detected in children in a reference hospital. The severity of the symptoms was mild-moderate in the majority with a predominance of febrile syndrome, with mild radiological involvement and in some cases with mild respiratory distress that required oxygen therapy. The rational and prudent management of these patients is discussed, evaluating possible treatments and options for hospitalization or outpatient follow-up. Conclusion: In our experience, monitoring of children with immunosuppression and COVID-19 disease can be performed as outpatients if close monitoring is possible. Hospitalization should be assessed when high fever, radiological involvement, and/or respiratory distress are present. url: https://doi.org/10.1007/s00431-020-03793-3 doi: 10.1007/s00431-020-03793-3 id: cord-290658-r2bqqovo author: Qian, Hao title: Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: a Retrospective in-ICU Study date: 2020-10-16 words: 3550.0 sentences: 197.0 pages: flesch: 44.0 cache: ./cache/cord-290658-r2bqqovo.txt txt: ./txt/cord-290658-r2bqqovo.txt summary: OBJECTIVE: The aim of this study was to investigate the incidence, clinical presentation, cardiovascular (CV) complications and mortality risk of myocardial injury on admission in critically ill ICU inpatients with COVID-19. We conducted a retrospective study of data from 77 patients admitted to a newly constructed ICU in Wuhan, compared patients with and without myocardial injury, detailed the relationship of myocardial injury with the survival rate and CV outcomes, and presented the following conclusions: 1) Myocardial injury is a common complication in critically ill COVID-19 patients; 2) Additionally, we further compared the mortality and time from ICU admission to death between the myocardial injury and non-myocardial injury patients, which suggested the predictive value of co-existing myocardial injury on admission as a high-risk factor in critically ill patients with COVID-19 in this study. abstract: OBJECTIVE: The aim of this study was to investigate the incidence, clinical presentation, cardiovascular (CV) complications and mortality risk of myocardial injury on admission in critically ill ICU inpatients with COVID-19. DESIGN: A single-center, retrospective, observational study. SETTING: A new-built ICU in Tongji hospital (Sino-French new city campus), Huazhong University of Science and Technology, Wuhan, China. PARTICIPANTS: Seventy-seven critical COVID-19 patients. INTERVENTIONS: Patients were divided into myocardial injury group and non-myocardial injury group according to the on-admission levels of high-sensitivity cardiac troponin I. MEASUREMENTS AND MAIN RESULTS: Demographic data, clinical characteristics, laboratory tests, treatment and clinical outcome were evaluated stratified by the presence of myocardial injury on admission. Compared with non-myocardial injury patients, patients with myocardial injury were older (68.4 ± 10.1 vs. 62.1 ± 13.5 years; P=0.02), had higher prevalence of underlying CV disease (34.1% vs. 11.1%; P=0.02) and in-ICU CV complications (41.5% vs13.9%; P=0.008), higher Acute Physiology and Chronic Health Evaluation II scores (20.3 ± 7.3 vs 14.4 ± 7.4; P=0.001) and Sequential Organ Failure Assessment scores [7, interquartile range (IQR) 5-10 vs. 5,IQR 3-6; P<0.001]. Myocardial injury on admission increased the risk of 28-day mortality [hazard ratio (HR), 2.200; 95% confidence interval (CI) 1.29 to 3.74; P=0.004]. Age ≥ 75 years was another risk factor for mortality (HR, 2.882; 95% CI 1.51 to 5.50; P=0.002). CONCLUSION: Critically ill patients with COVID-19 held high risk of CV complications. Myocardial injury on admission may be a common comorbidity and is associated with severity and a high risk of mortality in this population. url: https://www.sciencedirect.com/science/article/pii/S1053077020311332?v=s5 doi: 10.1053/j.jvca.2020.10.019 id: cord-346616-kr500kgj author: Qian, Song-Zan title: Clinical Characteristics and Outcomes of Severe and Critical Patients With 2019 Novel Coronavirus Disease (COVID-19) in Wenzhou: A Retrospective Study date: 2020-09-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Information about severe cases of 2019 novel coronavirus disease (COVID-19) infection is scarce. The aim of this study was to report the clinical characteristics and outcomes of severe and critical patients with confirmed COVID-19 infection in Wenzhou city. In this single-centered, retrospective cohort study, we consecutively enrolled 37 RT-PCR confirmed positive severe or critical patients from January 28 to February 16, 2020 in a tertiary hospital. Outcomes were followed up until 28-day mortality. Fifteen severe and 22 critical adult patients with the COVID-19 infection were included. Twenty-six (68.4%) were men. Echocardiography data results suggest that normal or increased cardiac output and diastolic dysfunction are the most common manifestations. Compared with severe patients, critical patients were older, more likely to exhibit low platelet counts and high blood urea nitrogen, and were in hospital for longer. Most patients had organ dysfunction during hospitalization, including 11 (29.7%) with ARDS, 8 (21.6%) with acute kidney injury, 17 (45.9%) with acute cardiac injury, and 33 (89.2%) with acute liver dysfunction. Eighteen (48.6%) patients were treated with high-flow ventilation, 9 (13.8%) with non-invasive ventilation, 10 (15.4%) with invasive mechanical ventilation, 7 (18.9%) with prone position ventilation, 6 (16.2%) with extracorporeal membrane oxygenation (ECMO), and 3 (8.1%) with renal replacement therapy. Only 1 (2.7%) patient had died in the 28-day follow up in our study. All patients had bilateral infiltrates on their chest CT scan. Twenty-one (32.3%) patients presented ground glass opacity (GGO) with critical patients more localized in the periphery and the center. The mortality of critical patients with the COVID-19 infection is low in our study. Cardiac function was enhanced in the early stage and less likely to develop into acute cardiac injury, but most patients suffered with acute liver injury. The CT imaging presentations of COVID-19 in critical patients were more likely with consolidation and bilateral lung involvement. url: https://doi.org/10.3389/fmed.2020.552002 doi: 10.3389/fmed.2020.552002 id: cord-304271-vyayyk50 author: Qin, Yuan-Yuan title: Effectiveness of glucocorticoid therapy in patients with severe coronavirus disease 2019: protocol of a randomized controlled trial date: 2020-03-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: At the end of 2019, a novel coronavirus outbreak emerged in Wuhan, China, and its causative organism has been subsequently designated the 2019 novel coronavirus (2019-nCoV). The effectiveness of adjunctive glucocorticoid therapy in the management of 2019-nCoV-infected patients with severe lower respiratory tract infections is not clear, and warrants further investigation. METHODS: The present study will be conducted as an open-labeled, randomized, controlled trial. We will enrol 48 subjects from Chongqing Public Health Medical Center. Each eligible subject will be assigned to an intervention group (methylprednisolone via intravenous injection at a dose of 1–2 mg/kg/day for 3 days) or a control group (no glucocorticoid use) randomly, at a 1:1 ratio. Subjects in both groups will be invited for 28 days of follow-up which will be scheduled at four consecutive visit points. We will use the clinical improvement rate as our primary endpoint. Secondary endpoints include the timing of clinical improvement after intervention, duration of mechanical ventilation, duration of hospitalization, overall incidence of adverse events, as well as rate of adverse events at each visit, and mortality at 2 and 4 weeks. DISCUSSION: The present coronavirus outbreak is the third serious global coronavirus outbreak in the past two decades. Oral and parenteral glucocorticoids have been used in the management of severe respiratory symptoms in coronavirus-infected patients in the past. However, there remains no definitive evidence in the literature for or against the utilization of systemic glucocorticoids in seriously ill patients with coronavirus-related severe respiratory disease, or indeed in other types of severe respiratory disease. In this study, we hope to discover evidence either supporting or opposing the systemic therapeutic administration of glucocorticoids in patients with severe coronavirus disease 2019. TRIAL REGISTRATION: ClinicalTrials.gov, ChiCTR2000029386, http://www.chictr.org.cn/showproj.aspx?proj=48777. url: https://doi.org/10.1097/cm9.0000000000000791 doi: 10.1097/cm9.0000000000000791 id: cord-324125-wau2xq0x author: Qiu, Chao title: Epidemiologic report and serologic findings for household contacts of three cases of influenza A (H7N9) virus infection date: 2013-12-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND AND OBJECTIVE: We conducted epidemiologic investigations and serologic assays on household contacts that were extensively exposed to three influenza A (H7N9) virus infected case-patients before infection-control practices were implemented. STUDY DESIGN: Data on the early clinical course of each patient and the exposure history for each patient's household contacts were obtained by interviewing household members and by reviewing medical records. Viral RNA in patient samples was tested using real-time reverse transcriptase polymerase chain reaction assay. Antibodies against H7N9 virus in serum samples were tested using hemagglutination inhibition and pseudovirus based neutralization assays. RESULTS: All household contacts were extensively exposed to the case-patients without the use of measures to protect against infection. Viral RNA was detected in the specimens from case-patients for approximately 7–11 days after confirmation of infection. However, the results of the analyses of serum specimens taken from the household contacts 15–26 days post exposure revealed no evidence of transmission of H7N9 virus from the case-patients to the contacts. CONCLUSION: Despite ample unprotected exposures to case-patients during the virus shedding period, household members in this report were not infected by the H7N9 virus. url: https://api.elsevier.com/content/article/pii/S1386653213005167 doi: 10.1016/j.jcv.2013.12.004 id: cord-255905-ti9b1etu author: Qiu, Chengfeng title: Transmission and clinical characteristics of coronavirus disease 2019 in 104 outside-Wuhan patients, China date: 2020-03-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Cases with coronavirus disease 2019 (COVID-19) emigrated from Wuhan escalated the risk of spreading in other cities. This report focused on the outside-Wuhan patients to assess the transmission and clinical characteristics of this illness. Methods: Contact investigation was conducted on each patient who admitted to the assigned hospitals in Hunan Province (geographically adjacent to Wuhan) from Jan 22, 2020 to Feb 12, 2020. Demographic, clinical, laboratory and radiological characteristics, medication therapy and outcomes were collected and analyzed. Patients were confirmed by PCR test. Results: Of the 104 patients, 48 (46.15%) were imported cases and 56 (53.85%) were indigenous cases; 93 (89.42%) had a definite contact history with infections. Family clusters were the major body of patients. Transmission along the chain of 3 &ldquo:generations” was observed. Mean age was 43 (rang, 8-84) years (including 3 children) and 49 (47.12%) were male. Most patients had typical symptoms, 5 asymptomatic infections were found and 2 of them infected their relatives. The median incubation period was 6 (rang, 1-32) days, of 8 patients ranged from 18 to 32 days. Just 9 of 16 severe patients required ICU care. Until Feb 12, 2020, 40 (38.46%) discharged and 1 (0.96%) died. For the antiviral treatment, 80 (76.92%) patients received traditional Chinese medicine therapy. Conclusions: Family but not community transmission occupied the main body of infections in the two centers. Asymptomatic transmission demonstrated here warned us that it may bring more risk to the spread of COVID-19. The incubation period of 8 patients exceeded 14 days. url: https://doi.org/10.1101/2020.03.04.20026005 doi: 10.1101/2020.03.04.20026005 id: cord-278256-dmrtsxik author: Qiu, Haiyan title: Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study date: 2020-03-25 words: 3458.0 sentences: 199.0 pages: flesch: 50.0 cache: ./cache/cord-278256-dmrtsxik.txt txt: ./txt/cord-278256-dmrtsxik.txt summary: title: Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study INTERPRETATION: Although all paediatric patients in our cohort had mild or moderate type of COVID-19, the large proportion of asymptomatic children indicates the difficulty in identifying paediatric patients who do not have clear epidemiological information, leading to a dangerous situation in community-acquired infections. All children with COVID-19 had been infected either by close contact with adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or by exposure to the epidemic area. By contrast with findings in adults, children with COVID-19 had milder clinical manifestations; nearly half of paediatric patients were asymptomatic (ie, no fever and no cough). When compared with children with SARS, paediatric patients with COVID-19 had much milder disease in terms of the prevalence of fever, cough, pneumonia, and severe case type. abstract: BACKGROUND: Since December, 2019, an outbreak of coronavirus disease 2019 (COVID-19) has spread globally. Little is known about the epidemiological and clinical features of paediatric patients with COVID-19. METHODS: We retrospectively retrieved data for paediatric patients (aged 0–16 years) with confirmed COVID-19 from electronic medical records in three hospitals in Zhejiang, China. We recorded patients' epidemiological and clinical features. FINDINGS: From Jan 17 to March 1, 2020, 36 children (mean age 8·3 [SD 3·5] years) were identified to be infected with severe acute respiratory syndrome coronavirus 2. The route of transmission was by close contact with family members (32 [89%]) or a history of exposure to the epidemic area (12 [33%]); eight (22%) patients had both exposures. 19 (53%) patients had moderate clinical type with pneumonia; 17 (47%) had mild clinical type and either were asymptomatic (ten [28%]) or had acute upper respiratory symptoms (seven [19%]). Common symptoms on admission were fever (13 [36%]) and dry cough (seven [19%]). Of those with fever, four (11%) had a body temperature of 38·5°C or higher, and nine (25%) had a body temperature of 37·5–38·5°C. Typical abnormal laboratory findings were elevated creatine kinase MB (11 [31%]), decreased lymphocytes (11 [31%]), leucopenia (seven [19%]), and elevated procalcitonin (six [17%]). Besides radiographic presentations, variables that were associated significantly with severity of COVID-19 were decreased lymphocytes, elevated body temperature, and high levels of procalcitonin, D-dimer, and creatine kinase MB. All children received interferon alfa by aerosolisation twice a day, 14 (39%) received lopinavir–ritonavir syrup twice a day, and six (17%) needed oxygen inhalation. Mean time in hospital was 14 (SD 3) days. By Feb 28, 2020, all patients were cured. INTERPRETATION: Although all paediatric patients in our cohort had mild or moderate type of COVID-19, the large proportion of asymptomatic children indicates the difficulty in identifying paediatric patients who do not have clear epidemiological information, leading to a dangerous situation in community-acquired infections. FUNDING: Ningbo Clinical Research Center for Children's Health and Diseases, Ningbo Reproductive Medicine Centre, and Key Scientific and Technological Innovation Projects of Wenzhou. url: https://api.elsevier.com/content/article/pii/S1473309920301985 doi: 10.1016/s1473-3099(20)30198-5 id: cord-356084-621qzpqd author: Qu, Jiuxin title: Profile of IgG and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We profiled the serological responses to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein and spike (S) glycoprotein. The majority of the patients developed robust antibody responses between 17 and 23 days after illness onset. Delayed, but stronger antibody responses were observed in critical patients. url: https://doi.org/10.1093/cid/ciaa489 doi: 10.1093/cid/ciaa489 id: cord-286843-8qh1pblc author: Quah, Jessica title: Impact of microbial Aetiology on mortality in severe community-acquired pneumonia date: 2018-09-04 words: 4060.0 sentences: 215.0 pages: flesch: 38.0 cache: ./cache/cord-286843-8qh1pblc.txt txt: ./txt/cord-286843-8qh1pblc.txt summary: Univariate and multivariate logistic regression showed that serum procalcitonin, APACHE II severity score and mixed viral-bacterial infection were associated with increased risk of hospital mortality. Postulated prohibitive factors against the routine performance of viral diagnostics tests in patients with severe CAP may include a lack of clear clinical guidelines, perceived low cost-effectiveness and the paucity of effective anti-viral therapies for respiratory viruses other than influenza. Our primary hypothesis was that respiratory viruses were important causative pathogens in severe CAP and was associated with increased mortality when present with bacterial pathogens in mixed viral-bacterial co-infections. performed a prospective observational study on physician practices in the use of respiratory virus diagnostics demonstrating that despite clinical guideline recommendations on testing of respiratory viruses during influenza season, less than half of patients admitted to the intensive care unit with pneumonia were tested for viral pathogens [14] . abstract: BACKGROUND: The impact of different classes of microbial pathogens on mortality in severe community-acquired pneumonia is not well elucidated. Previous studies have shown significant variation in the incidence of viral, bacterial and mixed infections, with conflicting risk associations for mortality. We aimed to determine the risk association of microbial aetiologies with hospital mortality in severe CAP, utilising a diagnostic strategy incorporating molecular testing. Our primary hypothesis was that respiratory viruses were important causative pathogens in severe CAP and was associated with increased mortality when present with bacterial pathogens in mixed viral-bacterial co-infections. METHODS: A retrospective cohort study from January 2014 to July 2015 was conducted in a tertiary hospital medical intensive care unit in eastern Singapore, which has a tropical climate. All patients diagnosed with severe community-acquired pneumonia were included. RESULTS: A total of 117 patients were in the study. Microbial pathogens were identified in 84 (71.8%) patients. Mixed viral-bacterial co-infections occurred in 18 (15.4%) of patients. Isolated viral infections were present in 32 patients (27.4%); isolated bacterial infections were detected in 34 patients (29.1%). Hospital mortality occurred in 16 (13.7%) patients. The most common bacteria isolated was Streptococcus pneumoniae and the most common virus isolated was Influenza A. Univariate and multivariate logistic regression showed that serum procalcitonin, APACHE II severity score and mixed viral-bacterial infection were associated with increased risk of hospital mortality. Mixed viral-bacterial co-infections were associated with an adjusted odds ratio of 13.99 (95% CI 1.30–151.05, p = 0.03) for hospital mortality. CONCLUSIONS: Respiratory viruses are common organisms isolated in severe community-acquired pneumonia. Mixed viral-bacterial infections may be associated with an increased risk of mortality. url: https://www.ncbi.nlm.nih.gov/pubmed/30180811/ doi: 10.1186/s12879-018-3366-4 id: cord-302864-2xnq1oq7 author: Quartuccio, Luca title: Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Approximately 5% of patients with coronavirus disease 2019 (COVID-19) develop a life-threatening pneumonia that often occurs in the setting of increased inflammation or “cytokine storm”. Anti-cytokine treatments are being evaluated but optimal patient selection remains unclear, and the aim of our study is to address this point. METHODS: Between February 29 to April 6, 2020, 111 consecutive hospitalized patients with COVID-19 pneumonia were evaluated in a single centre retrospective study. Patients were divided in two groups: 42 severe cases (TOCI) with adverse prognostic features including raised CRP and IL-6 levels, who underwent anti-cytokine treatments, mostly tocilizumab, and 69 standard of care patients (SOC). RESULTS: In the TOCI group, all received anti-viral therapy and 40% also received glucocorticoids. In TOCI, 62% of cases were ventilated and there were 3 deaths (17.8 ± 10.6 days, mean follow up) with 7/26 cases remaining on ventilators, without improvement, and 17/26 developed bacterial superinfection. One fatality occurred in the 15 TOCI cases treated on noninvasive ventilation and 1 serious bacterial superinfection. Of the 69 cases in SOC, there was no fatalities and no bacterial complications. The TOCI group had higher baseline CRP and IL-6 elevations (p < 0.0001 for both) and higher neutrophils and lower lymphocyte levels (p = 0.04 and p = 0.001, respectively) with the TOCI ventilated patients having higher markers than non-ventilated TOCI patients. CONCLUSION: Higher inflammatory markers, more infections and worse outcomes characterized ventilated TOCI cases compared to ward based TOCI. Despite the confounding factors, this suggests that therapy time in anti-cytokine randomized trials will be key. url: https://www.sciencedirect.com/science/article/pii/S1386653220301864?v=s5 doi: 10.1016/j.jcv.2020.104444 id: cord-333451-p2plpeew author: Raab, Anja M. title: Significant demands on healthcare resources during the COVID crisis date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1038/s41393-020-0482-y doi: 10.1038/s41393-020-0482-y id: cord-324669-qca0uwxo author: Radermecker, Coraline title: Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19 date: 2020-09-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Infection with SARS-CoV-2 is causing a deadly and pandemic disease called coronavirus disease–19 (COVID-19). While SARS-CoV-2–triggered hyperinflammatory tissue-damaging and immunothrombotic responses are thought to be major causes of respiratory failure and death, how they relate to lung immunopathological changes remains unclear. Neutrophil extracellular traps (NETs) can contribute to inflammation-associated lung damage, thrombosis, and fibrosis. However, whether NETs infiltrate particular compartments in severe COVID-19 lungs remains to be clarified. Here we analyzed postmortem lung specimens from four patients who succumbed to COVID-19 and four patients who died from a COVID-19–unrelated cause. We report the presence of NETs in the lungs of each COVID-19 patient. NETs were found in the airway compartment and neutrophil-rich inflammatory areas of the interstitium, while NET-prone primed neutrophils were present in arteriolar microthrombi. Our results support the hypothesis that NETs may represent drivers of severe pulmonary complications of COVID-19 and suggest that NET-targeting approaches could be considered for the treatment of uncontrolled tissue-damaging and thrombotic responses in COVID-19. url: https://doi.org/10.1084/jem.20201012 doi: 10.1084/jem.20201012 id: cord-270509-roc93m4f author: Radhakrishnan, Suma title: Guidelines for Surgical Tracheostomy and Tracheostomy Tube Change During the COVID-19 Pandemic: A Review Article date: 2020-06-22 words: 1523.0 sentences: 138.0 pages: flesch: 53.0 cache: ./cache/cord-270509-roc93m4f.txt txt: ./txt/cord-270509-roc93m4f.txt summary: We also did explore the current literature and recommendations for tracheostomy in patients with COVID-19 and studied the previous data from severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), the virus responsible for the SARS outbreak of 2003. • The benefit of performing early tracheostomy in critically ill COVID-19 patients are unclear from available data [1] . • To reduce time in contact with aerosolized secretionscomplete paralysis of patient to prevent coughing; stopping mechanical ventilation just before entering trachea; reducing use of suction during the procedure [14] . 4. Tracheotomy is performed under direct vision without movement of patient; tracheostomy tube is inserted, followed by inflation of the balloon. Effect of early versus late or no tracheostomy on mortality and pneumonia of critically ill patients receiving mechanical ventilation: a systematic review and metaanalysis Surgical considerations for tracheostomy during the COVID-19 pandemic: lessons learned from the severe acute respiratory syndrome outbreak abstract: The novel corona virus disease (COVID-19) has unfolded into a pandemic and is continuing to propagate at a frightening speed. The aim of this article is to share our protocol for performing a safe surgical tracheostomy in this COVID-19 era. Tracheostomy procedures have a high risk of aerosol generation. To standardize institutional safety measures with tracheostomy, we advocate using a dedicated tracheostomy protocol applicable to all patients including those suspected of having COVID-19. We also did explore the current literature and recommendations for tracheostomy in patients with COVID-19 and studied the previous data from severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), the virus responsible for the SARS outbreak of 2003. We have prepared a protocol for performing a safe surgical tracheotomy in patients affected by COVID-19. Surgeons who might be involved in performing the tracheostomies should become familiar with these guidelines. url: https://www.ncbi.nlm.nih.gov/pubmed/32719738/ doi: 10.1007/s12070-020-01893-y id: cord-344270-874i31h8 author: Radke, Robert M title: Adult congenital heart disease and the COVID-19 pandemic date: 2020-06-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Adults with congenital heart disease (ACHD) may be at high risk in the case of COVID-19. Due to the heterogeneity of ACHD and secondary complications, risk profiles are, however, not uniform. This document aims to give an overview of relevant data and outline our pragmatic approach to disease prevention and management. Based on anatomy and additional physiological factors including symptoms, exercise capacity, heart failure, pulmonary hypertension and cyanosis, we propose a pragmatic approach to categorising patients into low-risk, intermediate-risk and high-risk groups. We regard especially patients with complex cyanotic conditions, those with palliated univentricular hearts, heart failure, severe valvular disease or pulmonary hypertension as high-risk patients. To avoid infection, we recommend self-isolation and exemption from work for these cohorts. Infected ACHD patients with low or moderate risk and without signs of deterioration may be remotely followed and cared for at home while in self isolation. High-risk patients or those with signs of respiratory or cardiovascular impairment require admission ideally at a tertiary ACHD centre. Especially patients with complex, cyanotic disease, heart failure and arrhythmias require particular attention. Treatment in patients with cyanotic heart disease should be guided by the relative degree of desaturation compared with baseline and lactate levels rather than absolute oxygen saturation levels. Patients with right heart dilatation or dysfunction are potentially at increased risk of right heart failure as mechanical ventilation and acute respiratory distress syndrome can lead to increase in pulmonary arterial pressures. url: https://www.ncbi.nlm.nih.gov/pubmed/32522822/ doi: 10.1136/heartjnl-2020-317258 id: cord-345445-9t1vebey author: Radmanesh, Alireza title: COVID-19–associated Diffuse Leukoencephalopathy and Microhemorrhages date: 2020-05-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Diffuse leukoencephalopathy and juxtacortical and/or callosal microhemorrhages were brain imaging features in critically ill patients with coronavirus disease 2019. Coronavirus disease 2019 (COVID-19) has been reported in association with a variety of brain imaging findings such as ischemic infarct, hemorrhage, and acute hemorrhagic necrotizing encephalopathy. Herein, the authors report brain imaging features in 11 critically ill patients with COVID-19 with persistently diminished mental status who underwent MRI between April 5 and April 25, 2020. These imaging features include (a) confluent T2 hyperintensity and mild restricted diffusion in bilateral supratentorial deep and subcortical white matter (in 10 of 11 patients) and (b) multiple punctate microhemorrhages in juxtacortical and callosal white matter (in seven of 11 patients). The authors also discuss potential pathogeneses. © RSNA, 2020 Online supplemental material is available for this article. url: https://www.ncbi.nlm.nih.gov/pubmed/32437314/ doi: 10.1148/radiol.2020202040 id: cord-319333-jwbgytwd author: Radmard, Sara title: Inpatient Neurology Consultations During the Onset of the SARS-CoV-2 New York City Pandemic: A Single Center Case Series date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily causes respiratory illness. However, neurological sequelae from novel coronavirus disease 2019 (COVID-19) can occur. Patients with neurological conditions may be at higher risk of developing worsening of their underlying problem. Here we document our initial experiences as neurologic consultants at a single center quaternary hospital at the epicenter of the COVID-19 pandemic. Methods: This was a retrospective case series of adult patients diagnosed with SARS-CoV-2 who required neurological evaluation in the form of a consultation or primary neurological care from March 13, 2020 to April 1, 2020. Results: Thirty-three patients (ages 17–88 years) with COVID-19 infection who required neurological or admission to a primary neurology team were included in this study. The encountered neurological problems associated with SARS-CoV-2 infection were encephalopathy (12 patients, 36.4%), seizure (9 patients, 27.2%), stroke (5 patients, 15.2%), recrudescence of prior neurological disease symptoms (4 patients, 12.1%), and neuromuscular (3 patients, 9.1%). The majority of patients who required evaluation by neurology had elevated inflammatory markers. Twenty-one (63.6%) patients were discharged from the hospital and 12 (36.4%) died from COVID-19 related complications. Conclusion: This small case series of our initial encounters with COVID-19 infection describes a range of neurological complications which are similar to presentations seen with other critical illnesses. COVID-19 infection did not change the overall management of neurological problems. url: https://www.ncbi.nlm.nih.gov/pubmed/32754113/ doi: 10.3389/fneur.2020.00805 id: cord-281945-jvnjzjds author: Radnis, Caitlin title: Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia date: 2020-09-06 words: 2808.0 sentences: 155.0 pages: flesch: 43.0 cache: ./cache/cord-281945-jvnjzjds.txt txt: ./txt/cord-281945-jvnjzjds.txt summary: Survivors of critical illness and ARDS often experience neurocognitive impairment but, to date, there is scant literature correlating radiographic hypoxic brain injury to hypoxemia related to ARDS. In this case series, we describe three cases of hypoxic brain injury seen on magnetic resonance imaging (MRI) in patients with hypoxemia secondary to COVID-19-related ARDS. Of patients with severe disease, approximately 16% had acute respiratory distress syndrome (ARDS), 14.5% required invasive mechanical ventilation, and 99% had pneumonia [4] . A recent autopsy case series found evidence of hypoxic changes in the brain tissue of patients who had succumbed to COVID-19, but there was no report of whether these patients developed ARDS, duration of mechanical ventilation if required, whether extracorporeal membrane oxygenation (ECMO) was used, presence or absence of cardiac arrest, or cause of death [21] . In this case series, we describe three cases of hypoxic brain injury seen on MRI, along with clinical correlations, in patients with hypoxemia secondary to COVID-19 related ARDS. abstract: The novel coronavirus SARS-CoV-2 is known to cause hypoxemia and acute respiratory distress syndrome (ARDS) in a significant portion of those with severe disease. Survivors of critical illness and ARDS often experience neurocognitive impairment but, to date, there is scant literature correlating radiographic hypoxic brain injury to hypoxemia related to ARDS. In this case series, we describe three cases of hypoxic brain injury seen on magnetic resonance imaging (MRI) in patients with hypoxemia secondary to COVID-19-related ARDS. The lack of severe observed hypoxemia in two of the cases suggests that unrecognized or asymptomatic hypoxemia may play a role in hypoxic brain injury related to COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32957036/ doi: 10.1016/j.jns.2020.117119 id: cord-259984-csdf1a69 author: Raffiq, Azman title: COVID-19 Pandemic and Its Impact on Neurosurgery Practice in Malaysia: Academic Insights, Clinical Experience and Protocols from March till August 2020 date: 2020-10-27 words: 16400.0 sentences: 871.0 pages: flesch: 47.0 cache: ./cache/cord-259984-csdf1a69.txt txt: ./txt/cord-259984-csdf1a69.txt summary: For emergent/unavoidable case for a known or undetermined COVID-19 patient, the surgeon and all OT personnel in the surgical suite should use PAPR, which filter the air being breathed in addition to face shields and other standard PPE. In routine clinical care of COVID-19 suspected or confirmed infections, surgical masks are acceptable PPE, except in the case of aerosol generating procedures (intubation, high flow nasal cannula, non-invasive ventilation, bronchoscopy, administration of nebulised medications, etc). Hospitals, professional societies and ministries of health could also provide physician and nursing staff with basic ICU and ventilator management refresher education to improve their capacity to care for COVID-19 patients. Designated COVID-19 hospitals may not be able to support all elective cases, in particular those that require post-operative intensive care or significant use of blood and blood products Surgeons, in consultation with anaesthetist, nursing colleagues as well as patients (or legally accepted next of kin), should weigh the risks of proceeding (exposure, lack of resources) against those of deferment, (progression of disease, worse patients outcomes) including the expectation of delay of 2-3 months or more or until the COVID-19 is less prevalent Figure 6 . abstract: The newly discovered coronavirus disease 2019 (COVID-19) is an infectious disease introduced to humans for the first time. Following the pandemic of COVID-19, there is a major shift of practices among surgical departments in response to an unprecedented surge in reducing the transmission of disease. With pooling and outsourcing of more health care workers to emergency rooms, public health care services and medical services, further in-hospital resources are prioritised to those in need. It is imperative to balance the requirements of caring for COVID-19 patients with imminent risk of delay to others who need care. As Malaysia now approaches the recovery phase following the pandemic, the crisis impacted significantly on neurosurgical services throughout the country. Various emergency measures taken at the height of the crisis may remain as the new normal in the provision of neurosurgical services and practices in Malaysia. The crisis has certainly put a strain on the effective delivery of services and as we approach the recovery era, what may have been a strain may prove to be a silver lining in neurosurgical services in Malaysia. The following details are various measures put in place as the new operational protocols for neurosurgical services in Malaysia. url: https://www.ncbi.nlm.nih.gov/pubmed/33154710/ doi: 10.21315/mjms2020.27.5.14 id: cord-285467-uxfk6k3c author: Ragni, Enrico title: Management of osteoarthritis during COVID‐19 pandemic date: 2020-05-21 words: 7077.0 sentences: 353.0 pages: flesch: 37.0 cache: ./cache/cord-285467-uxfk6k3c.txt txt: ./txt/cord-285467-uxfk6k3c.txt summary: Since an effective immune response against viral infections depends on cytotoxic T cells activation (25) , experimental evidence supports the observation that overexpression of inflammatory cytokines like IL-6 during the viral immune response might be associated with a decreased viral clearance by impairing the polarization and functionality of Th1 and CD8 cells (26), contributing to the worsening of the COVID-19 symptoms, and their management may appear an intriguing therapeutical approach. Overall, the administration of drugs for the control of inflammation, inhibiting the response of the immune system, may be detrimental in the initial phases of the viral infection, reducing the ability of the body to react to the presence of SARS-CoV-2, as observed in patients chronically treated for rheumatoid arthritis (27) . All rights reserved This shall prompt orthopaedics and clinicians in general to evaluate with extreme care the clinical conditions of OA patients not only under the perspective of OA symptoms management but also for undercurrent comorbidities, naturally occurring or OA-treatment-related, that, in the era of COVID-19 pandemic, may strongly affect patients outcomes more than the net combination of SARS-CoV-2 infection and OA. abstract: The pandemic spread of the new COVID‐19 coronavirus infection in China first, and all over the world at present, has become a global health emergency due to the rapidly increasing number of affected patients. Currently, a clear relationship between COVID‐19 infection incidence and/or complications due to chronic or occasional treatments for other pathologies is still not clear, albeit COVID‐19 pandemic may condition the treatment strategy of complex disorders, as osteoarthritis (OA). Importantly, OA is the most common age‐related joint disease affecting more than 80% of people older than the age of 55, an age burden also shared with the highest severity in COVID‐19 patients. OA patients often show a large array of concomitant pathologies such as diabetes, inflammation and cardiovascular diseases that are again shared with COVID‐19 patients and may therefore increase complications. Moreover, different OA treatments such as NSAIDs, paracetamol, corticosteroids, opioids or other molecules have a wide array of iatrogenic effects, potentially increasing COVID‐19 secondary infection incidence or complications. In this review we critically analyse the evidences on either negative or positive effect of drugs commonly used to manage OA in this particular scenario. This would provide orthopaedic surgeons at first, and physicians, pharmacologists and clinicians at general, a comprehensive description about the safety of the current pharmacological approaches and a decision making tool to treat their OA patients as the coronavirus pandemic continues. url: https://www.ncbi.nlm.nih.gov/pubmed/32438454/ doi: 10.1002/cpt.1910 id: cord-035315-j5mknuv5 author: Rahim, Fawad title: Mortality of Patients With Severe COVID-19 in the Intensive Care Unit: An Observational Study From a Major COVID-19 Receiving Hospital date: 2020-10-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective To determine the mortality of patients with severe COVID-19 in the intensive care unit (ICU) in relation to age, gender, co-morbidities, ventilatory status, and length of stay (LOS). Methods This was a cross-sectional study based on data retrieved for 204 patients admitted to the ICU of Hayatabad Medical Complex, Peshawar, Pakistan, from April to August 2020. Study variables were age, gender, co-morbid conditions, ventilatory status, and length of stay (LOS). The data were analyzed using SPSS version 21 (IBM Corp., Armonk, NY). The independent t-test and the chi-square test were used to compare the means and frequencies of variables. Multivariate regression analysis was used to predict the likelihood of mortality. Results The overall mortality was 77%. Non-invasive ventilation (NIV) was administered to 61.8% of patients. Mortality was higher for invasive mechanical ventilation (IMV) (93.6% vs 66.7%, p<0.001) and for over 60 years (87.3% vs 72.3%, p=0.019). Mortality without co-morbidities was 75.2%. Comparative mortality rates for at least one co-morbidity (79.7%), diabetes mellitus (80.0%), hypertension (100%), diabetes mellitus and hypertension both (87.1%), and chronic obstructive pulmonary disease (75%) were insignificant. The LOS for survivors was longer (8.9±8.9 versus 5.4±5.2 days, p=0.017). The LOS < 24h was associated with higher mortality (85.9% vs 72.9%, p=0.040). On multivariable regression, the likelihood of mortality was high for IMV (7.330, 95% CI 2.667 - 20.143, p<0.001) and elderly (>60 years) patients (2.607, 95%CI 1.063 - 6.394, p=0.036). Mortality decreased with LOS longer than 24h (0.412, 95%CI 0.173 - 0.982, p=0.045). Co-morbidities did not have any effect on mortality. Conclusions Age more than 60 years and IMV were independent risk factors for higher mortality. Longer ICU stay, specifically more than 24 hours, was associated with lower mortality but LOS less than 24 hours might not have a causal relationship with mortality. The odds of survival were not affected by co-morbidities. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657313/ doi: 10.7759/cureus.10906 id: cord-261380-xms5su6w author: Rahmani, Hamid title: Interferon β-1b in treatment of severe COVID-19: a randomized clinical trial date: 2020-08-24 words: 2770.0 sentences: 170.0 pages: flesch: 51.0 cache: ./cache/cord-261380-xms5su6w.txt txt: ./txt/cord-261380-xms5su6w.txt summary: Among an open-label, randomized clinical trial, adult patients (≥ 18 years old) with severe COVID-19 were randomly assigned (1:1) to the IFN group or the control group. According to the presence of this evidence, IFN β was considered as a promising option for the treatment of In this open-label, randomized clinical trial, efficacy and safety of IFN β-1b in the treatment of patients with severe CoVID-19 were assessed. This open-label, randomized clinical trial was designed to evaluate the efficacy and safety of IFN β-1b in the treatment of patients with CoVID19 Adult patients (≥ 18 years old) with positive PCR and clinical symptoms/signs of pneumonia (including dyspnea, cough and fever), peripheral oxygen saturation (SPO 2 ) ≤ 93 % in ambient air or arterial oxygen partial pressure to fractional inspired oxygen (PaO 2 /FiO 2 ) < 300 or SPO 2 /FiO 2 < 315 and lung involvement in chest imaging were included. abstract: In this study, efficacy and safety of interferon (IFN) β-1b in the treatment of patients with severe COVID-19 were evaluated. Among an open-label, randomized clinical trial, adult patients (≥ 18 years old) with severe COVID-19 were randomly assigned (1:1) to the IFN group or the control group. Patients in the IFN group received IFN β-1b (250 mcg subcutaneously every other day for two consecutive weeks) along with the national protocol medications while in the control group, patients received only the national protocol medications (lopinavir/ritonavir or atazanavir/ritonavir plus hydroxychloroquine for 7-10 days). The primary outcome of the study was time to clinical improvement. Secondary outcomes were in-hospital complications and 28-daymortality. Between April 20 and May 20, 2020, 80 patients were enrolled and finally 33 patients in each group completed the study. Time to clinical improvment in the IFN group was significantly shorter than the control group ([9(6-10) vs. 11(9-15) days respectively, p=0.002, HR= 2.30; 95% CI: 1.33-3.39]). At day 14, the percentage of discharged patients was 78.79% and 54.55% in the IFN and control groups respectively (OR= 3.09; 95% CI: 1.05-9.11, p=0.03). ICU admission rate in the control group was significantly higher than the IFN group (66.66% vs. 42.42%, p = 0.04). The duration of hospitalization and ICU stay were not significantly different between the groups All-cause 28-day mortality was 6.06% and 18.18% in the IFN and control groups respectively (p = 0.12). IFN β-1b was effective in shortening the time to clinical improvement without serious adverse events in patients with severe COVID-19. Furthermore, admission in ICU and need for invasive mechanical ventilation decreased following administration of IFN β-1b. Although 28-day mortality was lower in the IFN group, further randomized clinical trials with large sample size are needed for exact estimation of survival benefit of IFN β-1b. url: https://doi.org/10.1016/j.intimp.2020.106903 doi: 10.1016/j.intimp.2020.106903 id: cord-346664-ilebaqx3 author: Rahul title: Non-COVID Surgical Emergency During the Nationwide Lockdown due to Corona Pandemic: a Critical Appraisal date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The World Health Organization (WHO) declared corona infection as a pandemic in February 2020. A nationwide lockdown was enforced by Indian government on 25 March 2020. Separate health facilities were developed to handle the confirmed and suspected cases of COVID-19 (coronavirus disease). Other than emergency services and care of cancer patients, all remaining healthcare activities were curtailed. Through this study, we intend to assess any change in number and pattern of non-COVID surgical emergencies during the lockdown as well as the interventions required. This was an observational study which included all patients with surgical emergencies who presented during the study period (25 March to 24 April 2020) after two stage screenings for corona infection (group 2). The results obtained from analysis of prospectively collected database were compared with a similar period (group 1) prior to the onset of pandemic in India using appropriate statistical tests. In group 2, an increase (17%) in number of patients was noted. The need of organ support was more than 4 times the usual period. An upsurge in neurosurgical emergencies was noted, though the number of interventions decreased by 40%. A significant decrease in hospital stay was also documented (7 days vs 12 days). The nationwide lockdown led to an increase and change in pattern of surgical emergencies, though the interventions required were less. Effective management entails appropriate preparedness. url: https://doi.org/10.1007/s12262-020-02549-5 doi: 10.1007/s12262-020-02549-5 id: cord-270391-703js942 author: Rai, Harpreet K title: Atypical Presentation of Panhypopituitarism date: 2020-07-09 words: 1699.0 sentences: 116.0 pages: flesch: 41.0 cache: ./cache/cord-270391-703js942.txt txt: ./txt/cord-270391-703js942.txt summary: Additional workup showed a deficiency of all the anterior pituitary hormones likely secondary to mass effect. Pituitary apoplexy, for example, presents with the rapid development of symptoms causing sudden impairment of adrenocorticotropic hormone (ACTH) secretion and, consequently, the sudden onset of cortisol deficiency symptoms. We describe a patient who presented following a syncopal episode with a wide range of differential diagnoses based on initial laboratory results, clinical course, and workup, ultimately leading to the diagnosis of panhypopituitarism. 2020 The patient was discharged with recommendations for outpatient follow-up with the endocrinology team for continued monitoring of his pituitary hormone level deficiencies and sellar mass. Patients admitted to the hospital for further workup of syncope usually undergo an extensive cardiac and neurological assessment. The patient presented above was diagnosed with a sellar mass leading to hyposecretion of all the pituitary hormones. Postural hypotension and syncope are the most common presentations of secondary adrenal insufficiency and panhypopituitarism. abstract: Hypopituitarism is a rare disorder. Hypopituitarism can present as a deficiency of individual anterior pituitary hormones (e.g., adrenocorticotropic hormone, thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, prolactin, growth hormone) or posterior pituitary hormones (e.g., oxytocin, vasopressin) or as the deficiency of all these pituitary hormones, also known as panhypopituitarism. Here, we discuss a 59-year-old man who presented with two episodes of unwitnessed syncope after an episode of vomiting. On admission, the patient was hypotensive to 88/54 mmHg, afebrile, and with a leukocyte count of 21.43 K/µL (reference range: 3.80 to 10.50 K/µL). CT scan of the head revealed a hyperdensity in the left intracranial internal carotid artery just proximal to the bifurcation, suggesting an artifact or presence of an embolus. Additional findings included a sellar mass with calcifications and suprasellar extensions. The patient was admitted for further workup of syncope. Other differential diagnoses included sepsis, stroke, cardiac arrhythmias, and pulmonary embolism. Sepsis, stroke, and cardiac workup were negative for significant findings. The patient remained persistently hypotensive despite aggressive intravenous hydration, raising suspicion for an underlying endocrine disorder. MRI of the brain was negative for stroke but again was significant for a sellar mass. Additional workup showed a deficiency of all the anterior pituitary hormones likely secondary to mass effect. The patient was diagnosed with panhypopituitarism due to pituitary macroadenoma. url: https://doi.org/10.7759/cureus.9102 doi: 10.7759/cureus.9102 id: cord-354658-v451z3jq author: Rajagopal, Keshava title: Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. Based on preliminary clinical reports, hypoxic respiratory failure complicated by acute respiratory distress syndrome is the leading cause of death. Further, septic shock, late-onset cardiac dysfunction, and multiorgan system failure are also described as contributors to overall mortality. Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being utilized in the treatment of respiratory and circulatory failure refractory to conventional management, their role and efficacy as support modalities in the present pandemic are unclear. We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of COVID-19; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from ASAIO. Of note, this is a “living document,” which will be updated periodically, as additional information and understanding emerges. url: https://www.ncbi.nlm.nih.gov/pubmed/32358232/ doi: 10.1097/mat.0000000000001180 id: cord-011349-bykvn367 author: Rajasekaran, Raja Bhaskara title: Megaprosthesis in distal femur nonunions in elderly patients—experience from twenty four cases date: 2019-08-07 words: 3505.0 sentences: 218.0 pages: flesch: 53.0 cache: ./cache/cord-011349-bykvn367.txt txt: ./txt/cord-011349-bykvn367.txt summary: PURPOSE OF THE STUDY: To evaluate the outcomes and complications using cemented megaprosthesis in elderly patients with distal femur nonunions (DFN). MATERIALS AND METHODS: Between 2012 and 2016, 24 patients of DFN with an average age of 71.8 years (66–83) and an average 1.9(1–3) prior surgery was managed with distal femur replacement using cemented modular endoprosthesis. CONCLUSION: By permitting immediate full weight-bearing ambulation and with most patients returning to an acceptable functional status, cemented megaprosthesis is a viable and useful single-stage management option in elderly patients with DFN. Cemented modular endoprosthetic replacement in managing DFN is a welldescribed option which enables immediate weight-bearing following surgery leading to faster recovery of geriatric patients [9] [10] [11] . This study was performed to evaluate the outcomes and complications following cemented modular distal femoral endoprosthesis used in managing DFN in elderly patients. abstract: PURPOSE OF THE STUDY: To evaluate the outcomes and complications using cemented megaprosthesis in elderly patients with distal femur nonunions (DFN). MATERIALS AND METHODS: Between 2012 and 2016, 24 patients of DFN with an average age of 71.8 years (66–83) and an average 1.9(1–3) prior surgery was managed with distal femur replacement using cemented modular endoprosthesis. Outcomes were analysed on the following criteria: implant status, complications, knee range of motion, Knee Society Score (KSS) and Musculoskeletal Tumor Society (MSTS) score. RESULTS: All patients were extremely satisfied with their outcomes. At an average 22.1 months (10–43) follow-up, patients had an average 69.5° (40°-110°) knee flexion, an average KSS of 75.7 (63–88) and an average MSTS score of 19.3 (17–25). Four patients died at an average 21.3 months after surgery due to causes unrelated to the fracture. One patient (4.1%) had implant-related complication; deep infection which required debridement and intravenous antibiotics. There were no late amputations or peri-operative deaths and no patient had aseptic loosening of components. CONCLUSION: By permitting immediate full weight-bearing ambulation and with most patients returning to an acceptable functional status, cemented megaprosthesis is a viable and useful single-stage management option in elderly patients with DFN. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224092/ doi: 10.1007/s00264-019-04383-1 id: cord-321461-1s3y9kc5 author: Rajdev, Kartikeya title: Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting Evidence date: 2020-08-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus disease of 2019 (COVID-19) is caused by the binding of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to angiotensin-converting enzyme 2 (ACE2) receptors present on various locations such as the pulmonary alveolar epithelium and vascular endothelium. In COVID-19 patients, the interaction of SARS-CoV-2 with these receptors in the cerebral blood vessels has been attributed to stroke. Although the incidence of acute ischemic stroke is relatively low, ranging from 1% to 6%, the mortality associated with it is substantially high, reaching as high as 38%. This case series describes three distinct yet similar scenarios of COVID-19 positive patients with several underlying comorbidities, wherein two of the patients presented to our hospital with sudden onset right-sided weakness, later diagnosed with ischemic stroke, and one patient who developed an acute intracerebral hemorrhage during his hospital stay. The patients were diagnosed with acute stroke as a complication of COVID-19 infection. We also provide an insight into the possible mechanisms responsible for the life-threatening complication. Physicians should have a low threshold for suspecting stroke in COVID-19 patients, and close observation should be kept on such patients particularly those with clinical evidence of traditional risk factors. url: https://doi.org/10.7759/cureus.10157 doi: 10.7759/cureus.10157 id: cord-350408-rqlkwoya author: Rajewsky, Nikolaus title: LifeTime and improving European healthcare through cell-based interceptive medicine date: 2020-09-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade. url: https://doi.org/10.1038/s41586-020-2715-9 doi: 10.1038/s41586-020-2715-9 id: cord-274245-pgfqkwqg author: Rali, Aniket S title: Cardiopulmonary Ultrasonography for Severe Coronavirus Disease 2019 Patients in Prone Position date: 2020-05-14 words: 528.0 sentences: 38.0 pages: flesch: 45.0 cache: ./cache/cord-274245-pgfqkwqg.txt txt: ./txt/cord-274245-pgfqkwqg.txt summary: title: Cardiopulmonary Ultrasonography for Severe Coronavirus Disease 2019 Patients in Prone Position Upon arrival to the emergency room, the patient was noted to be severely hypoxaemic by pulse oximetry (66%) and in impeding respiratory failure, so she was emergently intubated for mechanical ventilatory support. The patient''s chest X-ray at the time of admission showed diffuse bilateral pulmonary opacities consistent with multifocal pneumonia or pulmonary oedema ( Figure 1 ). Polymerase chain reaction (PCR) testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was sent and came back positive after 48 hours. The patient was diagnosed with severe acute respiratory distress syndrome (ARDS), so was treated with inhaled pulmonary vasodilators, neuromuscular blockade and prone-position ventilation. Forty-eight hours after initial presentation, the patient''s PCR testing for SARS-CoV-2 returned positive, confirming the diagnosis of COVID-19. Critical care ultrasonography in acute respiratory failure abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32514381/ doi: 10.15420/cfr.2020.12 id: cord-262708-hctuxrw9 author: Ramachandra, C. title: Outcomes of Cancer Surgery During the COVID-19 Pandemic: Preparedness to Practising Continuous Cancer Care date: 2020-10-19 words: 2365.0 sentences: 127.0 pages: flesch: 45.0 cache: ./cache/cord-262708-hctuxrw9.txt txt: ./txt/cord-262708-hctuxrw9.txt summary: We were quick to adopt best practices and guidelines (PRINT ISSN No. 2277-8179/doi: 10.36106/ijsr) for cancer treatment during the pandemic as prescribed by Indian Association of Surgical Oncology (IASO)COVID-19 guidelines [6] and the Tata Memorial Centre COVID-19 working group [7] . At Kidwai Memorial Institute of Oncology (Regional Cancer Centre at Bengaluru, India) despite having to deescalate operations by about one-third, the department of surgical oncology and allied specialities made the decision to continue graded response in providing cancer care based on, for a centre with an annual registration of more than 25,000 new patients even a slowdown in clinical services is likely to have a deleterious impact on outcomes and a high plausible that surges of population infection, lock downs, resource competition and diagnostic bottlenecks could recur over the next few years and augment the delay in oncological care and its consequences [11] . abstract: The COVID-19 pandemic has placed unprecedented pressure on healthcare services. Deprioritisation of nonemergency clinical services and growing concerns of adverse outcomes of COVID-19 in cancer patients is having a deleterious impact across oncologic practice. We report cancer surgery outcomes taking into account the acuity of the COVID-19 situation. A prospectively maintained database of the Department of Surgical Oncology was analysed from 1st May to 30th June, 2020, to evaluate the perioperative outcomes, morbidity and mortality following major surgical procedures. A total of 359, preoperatively, tested negative for COVID-19 underwent surgery. Median age was 52 years with 26.7% (n = 96) above the age of 60 years. Sixty-one percent (n = 219) patients were American Society of Anaesthesiology grades II–III. As per surgical complexity grading, 36.8% (n = 132) cases were lower grades (I–III) and 63.2% (n = 227) were complex surgeries (IV–VI). 5.3% (n = 19) had ≥ grade III Clavien-Dindo complication, and the postoperative mortality rate was 0.27% (n = 1). Major complication rates in patients > 60 years were 9.3% in comparison to 4.1% in < 60 years (p = 0·63). The median hospital stay was 1–10 days across subspecialties. Postoperatively, repeat COVID 19 testing in 2 suspected patients were negative. Our study showed that after screening, triaging and prioritisation, asymptomatic cases may undergo cancer surgeries without increased morbidity during COVID-19 pandemic. url: https://doi.org/10.1007/s13193-020-01250-z doi: 10.1007/s13193-020-01250-z id: cord-352215-dhkvh45t author: Ramachandran, Preethi title: Increased serum aminotransferase activity and clinical outcomes in Coronavirus disease 2019 date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Elevation of hepatic aminotransferases (aspartate aminotransferase [AST]/alanine aminotransferase [ALT]) is commonly noted among COVID-19 patients. It is unclear if they can predict the clinical outcomes among hospitalized COVID-19 patients. We aim to assess if elevations in AST/ALT were associated with poor outcomes in hospitalized COVID-19 patients. METHODS: We retrospectively evaluated hospitalized COVID-19 patients with clinically significant elevated aminotransferases (defined as >2 times upper limit of normal) and compared them with COVID-19 patients without an elevation in aminotransferases. RESULTS: The prevalence of elevation in AST/ALT was found to be 13.7% (20/145). The two groups were similar in baseline demographics, comorbidities, and the majority of laboratory tests. There was no difference in the mortality (50% vs. 36.8%, P=0.32) and median hospital stay (7 days vs. 7 days, P=0.78). However, there was a statistically significant increase in the rates of mechanical ventilation among elevated aminotransferases group compared to individuals without elevation (50% vs. 24%, P= 0.028). However, this difference was not observed after adjusting for inflammatory markers such as ferritin, lactate dehydrogenase (LDH), and lactic acid levels. CONCLUSION: Elevated aminotransferases among hospitalized COVID-19 patients is associated with higher rates of mechanical ventilation, but did not achieve statistical significance after controlling for inflammatory markers. Also, patients with elevated aminotransferases did not have higher rates of mortality or prolonged length of stay. url: https://www.ncbi.nlm.nih.gov/pubmed/32837096/ doi: 10.1016/j.jceh.2020.06.009 id: cord-029466-9sy6icrm author: Ramadan, Ahmad Riad title: Tales of a department: how the COVID-19 pandemic transformed Detroit’s Henry Ford Hospital, Department of Neurology—part I: the surge date: 2020-07-12 words: 4345.0 sentences: 205.0 pages: flesch: 49.0 cache: ./cache/cord-029466-9sy6icrm.txt txt: ./txt/cord-029466-9sy6icrm.txt summary: In the first 2 weeks, the meetings were focused on ensuring the availability of personal protective equipment (PPE), the shutting down of all neurology outpatient and most inpatient activities, establishment of virtual care activity and seeking volunteers for redeployment openings listed by Incident Command on the daily leadership calls. In order to expand the number of ICU beds, the larger unit, consisting of 18 beds, became an extension of the medical ICU (MICU) for patients with confirmed or suspected COVID-19 and was staffed by internal medicine (IM) physicians and residents. Neurological checks and National Institutes of Health Stroke Scale assessments were performed using video devices to limit exposure to HCPs. Consensus was reached between the stroke team, neurointerventional team and radiology on an amended policy to manage patients receiving thrombectomy during the pandemic. Several neurology residents were redeployed to provide care for patients admitted to the COVID-19 unit under the supervision of an IM staff. abstract: The COVID-19 pandemic has reshaped the way healthcare systems operate around the world. The major hurdles faced have been availability of personal protective equipment, intensive care unit beds, ventilators, treatments and medical personnel. Detroit, Michigan has been an epidemic ‘hotspot’ in the USA with Wayne County among the hardest hit counties in the nation. The Department of Neurology at Henry Ford Hospital, in the heart of Detroit, has responded effectively to the pandemic by altering many aspects of its operations. The rapid engagement of the department and enhanced utilisation of teleneurology were two of the pivotal elements in the successful response to the pandemic. In this review, we describe the transformation our department has undergone, as it relates to its infrastructure redesigning, coverage restructuring, redeployment strategies, medical education adaptations and novel research initiatives. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371567/ doi: 10.1136/bmjno-2020-000070 id: cord-350923-532lnnll author: Ramalho, Renata title: Immunometabolism: new insights and lessons from antigen-directed cellular immune responses date: 2020-06-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Modulation of immune responses by nutrients is an important area of study in cellular biology and clinical sciences in the context of cancer therapies and anti-pathogen-directed immune responses in health and disease. We review metabolic pathways that influence immune cell function and cellular persistence in chronic infections. We also highlight the role of nutrients in altering the tissue microenvironment with lessons from the tumor microenvironment that shapes the quality and quantity of cellular immune responses. Multiple layers of biological networks, including the nature of nutritional supplements, the genetic background, previous exposures, and gut microbiota status have impact on cellular performance and immune competence against molecularly defined targets. We discuss how immune metabolism determines the differentiation pathway of antigen-specific immune cells and how these insights can be explored to devise better strategies to strengthen anti-pathogen-directed immune responses, while curbing unwanted, non-productive inflammation. url: https://www.ncbi.nlm.nih.gov/pubmed/32519148/ doi: 10.1007/s00281-020-00798-w id: cord-337094-aa3ourc6 author: Ramella, Vittorio title: Microsurgical reconstruction in the time of COVID‐19 date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32412677/ doi: 10.1002/micr.30604 id: cord-274121-3w6kc0c9 author: Ramiro, Sofia title: Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date: 2020-07-20 words: 5757.0 sentences: 267.0 pages: flesch: 47.0 cache: ./cache/cord-274121-3w6kc0c9.txt txt: ./txt/cord-274121-3w6kc0c9.txt summary: Objectives To prospectively investigate in patients with severe coVid-19-associated cytokine storm syndrome (css) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. Objectives To prospectively investigate in patients with severe coVid-19-associated cytokine storm syndrome (css) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. ► A strategy involving a course of high-dose glucocorticoids, followed by tocilizumab if needed, has shown to accelerate respiratory recovery, lower hospital mortality and reduce the likelihood of invasive mechanical ventilation compared with supportive care only in COVID-19-associated CSS. abstract: OBJECTIVES: To prospectively investigate in patients with severe COVID-19-associated cytokine storm syndrome (CSS) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. METHODS: From 1 April 2020, patients with COVID-19-associated CSS, defined as rapid respiratory deterioration plus at least two out of three biomarkers with important elevations (C-reactive protein >100 mg/L; ferritin >900 µg/L; D-dimer >1500 µg/L), received high-dose intravenous methylprednisolone for 5 consecutive days (250 mg on day 1 followed by 80 mg on days 2–5). If the respiratory condition had not improved sufficiently (in 43%), the interleukin-6 receptor blocker tocilizumab (8 mg/kg body weight, single infusion) was added on or after day 2. Control patients with COVID-19-associated CSS (same definition) were retrospectively sampled from the pool of patients (n=350) admitted between 7 March and 31 March, and matched one to one to treated patients on sex and age. The primary outcome was ≥2 stages of improvement on a 7-item WHO-endorsed scale for trials in patients with severe influenza pneumonia, or discharge from the hospital. Secondary outcomes were hospital mortality and mechanical ventilation. RESULTS: At baseline all patients with COVID-19 in the treatment group (n=86) and control group (n=86) had symptoms of CSS and faced acute respiratory failure. Treated patients had 79% higher likelihood on reaching the primary outcome (HR: 1.8; 95% CI 1.2 to 2.7) (7 days earlier), 65% less mortality (HR: 0.35; 95% CI 0.19 to 0.65) and 71% less invasive mechanical ventilation (HR: 0.29; 95% CI 0.14 to 0.65). Treatment effects remained constant in confounding and sensitivity analyses. CONCLUSIONS: A strategy involving a course of high-dose methylprednisolone, followed by tocilizumab if needed, may accelerate respiratory recovery, lower hospital mortality and reduce the likelihood of invasive mechanical ventilation in COVID-19-associated CSS. url: https://doi.org/10.1136/annrheumdis-2020-218479 doi: 10.1136/annrheumdis-2020-218479 id: cord-030531-4uucx9ss author: Randremanana, Rindra Vatosoa title: An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial date: 2020-08-17 words: 8049.0 sentences: 388.0 pages: flesch: 50.0 cache: ./cache/cord-030531-4uucx9ss.txt txt: ./txt/cord-030531-4uucx9ss.txt summary: All drugs in use for treating plague are registered based on experimental data and anecdotal evidence, and no regimen currently recommended is supported by a randomized clinical trial. The primary endpoint of the trial is to assess the proportion of patients with bubonic plague who have a therapeutic response to treatment (defined as alive, resolution of fever, 25% reduction in the size of measurable buboes, has not received an alternative treatment and no clinical decision to continue antibiotics) as assessed on day 11. The secondary objective is to collect data on the effectiveness of ciprofloxacin in the treatment of pneumonic plague, although the trial is not able to formally assess the non-inferiority of ciprofloxacin monotherapy compared to streptomycin and ciprofloxacin combination therapy in pneumonic plague, Considering the operational and practical complexities of a plague RCT, the study also has additional exploratory objectives to optimize investments: to evaluate the level and kinetics of anti-Y. abstract: BACKGROUND: Bubonic plague is the primary manifestation of infection with Yersinia pestis, accounting for 90% of all plague cases and with 75% of global cases reported in Madagascar. All drugs in use for treating plague are registered based on experimental data and anecdotal evidence, and no regimen currently recommended is supported by a randomized clinical trial. The IMASOY trial intends to fill this knowledge gap by comparing two 10-day regimens included in the national guidelines in Madagascar. The primary objective of the trial is to test the hypothesis that ciprofloxacin monotherapy is non-inferior to streptomycin followed by ciprofloxacin for the treatment of bubonic plague, thus avoiding the need for injectable, potentially toxic, aminoglycosides. METHODS: A two-arm parallel-group randomized control trial will be conducted across peripheral health centres in Madagascar in five districts. Males and non-pregnant females of all ages with suspected bubonic or pneumonic plague will be recruited over the course of three plague ‘seasons’. The primary endpoint of the trial is to assess the proportion of patients with bubonic plague who have a therapeutic response to treatment (defined as alive, resolution of fever, 25% reduction in the size of measurable buboes, has not received an alternative treatment and no clinical decision to continue antibiotics) as assessed on day 11. DISCUSSION: If successful, the trial has the potential to inform the standard of care guidelines not just in Madagascar but in other countries afflicted by plague. The trial is currently ongoing and expected to complete recruitment in 2022. TRIAL REGISTRATION: ClinicalTrials.gov NCT04110340. Registered on 1 October 2019 url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429934/ doi: 10.1186/s13063-020-04642-2 id: cord-351340-7y19ystp author: Rao, Gundu H. R. title: Coronavirus Disease and Acute Vascular Events date: 2020-07-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32735130/ doi: 10.1177/1076029620929091 id: cord-355524-qx396wq1 author: Rao, P Vishnu title: Clinical profile of respiratory viral infections: A study from tertiary care centre of South India date: 2017-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Background The recent influenza pandemic caused by the 2009 California H1N1strain increased awareness of the importance of influenza among hospitalized patients but there are few reports on other influenza strains and other non influenza respiratory viral infections in hospitalised patients. Aim To study epidemiological, clinical profile and outcome in patients hospitalised with respiratory viral infections. Materials and methods A prospective, observational study was conducted in a tertiary care hospital in Chennai, Tamil Nadu from September 2015 to July 2016. Respiratory samples from patients hospitalised with suspected acute viral respiratory infections were sent for molecular PCR based technique. Results Total 40 patients were studied. The most common respiratory virus was rhino virus in 9(22.5%) patients followed by influenza H3/H3N2 in 7(17.5%), H1N1 in 6(15%) and RSV in 4 (10%). After the diagnosis of the viral infection, antibiotics were completely stopped in 10(30.3%) patients and de-escalated to a narrower spectrum agent in another 10 (30.3%) patients. No patient whose antibiotics were de-escalated died, whereas there were 5 deaths in patients in whom de-escalation was not done. Conclusion Diagnosis with PCR facilitates early use of antiviral agents, droplet isolation, prevention of cross-transmission of viruses and antibiotic stewardship practice. url: https://api.elsevier.com/content/article/pii/S0976288417300772 doi: 10.1016/j.injms.2017.06.003 id: cord-254595-by2j7byz author: Rao, Sandesh S. title: Establishing Telemedicine in an Academic Total Joint Arthroplasty Practice: Needs and Opportunities Highlighted by the COVID-19 Pandemic date: 2020-04-23 words: 957.0 sentences: 57.0 pages: flesch: 48.0 cache: ./cache/cord-254595-by2j7byz.txt txt: ./txt/cord-254595-by2j7byz.txt summary: To help control spread of this pandemic, many centers have boosted telemedicine capability to care for patients who would typically be seen in person in outpatient settings, including total joint arthroplasty clinics. We review key components relevant to the establishment and effective use of telemedicine, focused on patient education, practice logistics, technological considerations, and sensitive patient health information–associated compliance factors, which are necessary to provide care remotely for total joint arthroplasty patients. Orthopaedic surgeons who primarily perform total joint arthroplasty (TJA) of the hip and 41 knee treat a predominantly outpatient population that is at high risk for complications and death 42 from 44, 54] Most patients of adult reconstruction clinics are older than 60 years, 43 and many have comorbidities that put them at high risk of contracting severe acute respiratory 44 syndrome coronavirus 2 (SARS-CoV-2) if exposed. [65] Therefore, an effective and efficient 45 TJA telemedicine practice may enable providers to continue delivering care while preventing 46 unnecessary exposure of at-risk patients to the outpatient clinic during this pandemic. abstract: The COVID-19 pandemic has prompted rapid restructuring of the healthcare system in an effort to stop the spread of the virus and to treat patients who are acutely ill with COVID-19, while continuing to provide outpatient care for the remainder of patients. To help control spread of this pandemic, many centers have boosted telemedicine capability to care for patients who would typically be seen in person in outpatient settings, including total joint arthroplasty clinics. We review key components relevant to the establishment and effective use of telemedicine, focused on patient education, practice logistics, technological considerations, and sensitive patient health information–associated compliance factors, which are necessary to provide care remotely for total joint arthroplasty patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32328510/ doi: 10.1016/j.artd.2020.04.014 id: cord-007577-f1jzbtjj author: Raphael Shulman, N. title: Hepatitis-associated antigen date: 2006-09-18 words: 13821.0 sentences: 577.0 pages: flesch: 39.0 cache: ./cache/cord-007577-f1jzbtjj.txt txt: ./txt/cord-007577-f1jzbtjj.txt summary: Frequency of HAA in acute hepatitis: After the initial suggestion in 1967 by Blumberg and co-workers [4] that Australia antigen might be related to the infectious agent of viral hepatitis, and the demonstration in 1968 by Okochi and Murakami [5] and Prince [6] that the antigen appeared in blood of patients during the incubation period of serum hepatitis, a number of investigators reported further evidence for existence of a hepatitis-associated antigen (Table II) . The antibodies used diagnostically to measure HAA by precipitin and complement fixation technics all come from patients who have received multiple transfusions and in whom high titer "hyperimmune" anti-HAA developed apparently as a result of repeated exposure to antigen in transfused blood. [29] tested serum obtained at weekly intervals from twenty-two patients with HAA-positive hepatitis during a one to two month period after onset of disease and found only one antibody detectable by agar gel precipitin technics and two antibodies of low titer detectable only by complement fixation. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119390/ doi: 10.1016/s0002-9343(70)80133-4 id: cord-304798-j2tyjo1j author: Rapkiewicz, Amy V. title: Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: There is increasing recognition of a prothrombotic state in COVID-19. Post-mortem examination can provide important mechanistic insights. METHODS: We present a COVID-19 autopsy series including findings in lungs, heart, kidneys, liver, and bone, from a New York academic medical center. FINDINGS: In seven patients (four female), regardless of anticoagulation status, all autopsies demonstrated platelet-rich thrombi in the pulmonary, hepatic, renal, and cardiac microvasculature. Megakaryocytes were seen in higher than usual numbers in the lungs and heart. Two cases had thrombi in the large pulmonary arteries, where casts conformed to the anatomic location. Thrombi in the IVC were not found, but the deep leg veins were not dissected. Two cases had cardiac venous thrombosis with one case exhibiting septal myocardial infarction associated with intramyocardial venous thrombosis, without atherosclerosis. One case had focal acute lymphocyte-predominant inflammation in the myocardium with no virions found in cardiomyocytes. Otherwise, cardiac histopathological changes were limited to minimal epicardial inflammation (n = 1), early ischemic injury (n = 3), and mural fibrin thrombi (n = 2). Platelet-rich peri‑tubular fibrin microthrombi were a prominent renal feature. Acute tubular necrosis, and red blood cell and granular casts were seen in multiple cases. Significant glomerular pathology was notably absent. Numerous platelet-fibrin microthrombi were identified in hepatic sinusoids. All lungs exhibited diffuse alveolar damage (DAD) with a spectrum of exudative and proliferative phases including hyaline membranes, and pneumocyte hyperplasia, with viral inclusions in epithelial cells and macrophages. Three cases had superimposed acute bronchopneumonia, focally necrotizing. INTERPRETATION: In this series of seven COVID-19 autopsies, thrombosis was a prominent feature in multiple organs, in some cases despite full anticoagulation and regardless of timing of the disease course, suggesting that thrombosis plays a role very early in the disease process. The finding of megakaryocytes and platelet-rich thrombi in the lungs, heart and kidneys suggests a role in thrombosis. FUNDING: None. url: https://www.sciencedirect.com/science/article/pii/S2589537020301784 doi: 10.1016/j.eclinm.2020.100434 id: cord-291670-mqj071gp author: Raredon, M. S. B. title: Pressure-Regulated Ventilator Splitting (PReVentS): A COVID-19 Response Paradigm from Yale University date: 2020-04-06 words: 8502.0 sentences: 488.0 pages: flesch: 56.0 cache: ./cache/cord-291670-mqj071gp.txt txt: ./txt/cord-291670-mqj071gp.txt summary: -Pressure-control ventilation mode is optimal and assumed for this design -Pressure readouts on the ventilator screen reflect unmodified pressures delivered by the ventilator, and are not representative of what each patient is seeing -PIP and PEEP for each patient are obtained by adding/subtracting each patient''s valve settings from displayed ventilator settings -see below -Tidal volume readout on the ventilator is total tidal volume for both patients -Additional monitors may be deployed in-line for each patient, to measure tidal volumes and airway pressures individually and in real time -FIO2 and respiratory rate are the same for both patients -Tidal volumes will differ for each patient, depending on PIP, PEEP and lung compliance -A short circuit from the ventilator outflow to ventilator inflow is necessary to avoid triggering of circuit occlusion alarm and to allow ventilator bias flow -Because of changes to the expected circuit, ventilator alarms will not always work as expected, and an alternate alarm strategy must be employed (see discussion below) abstract: In the current COVID-19 crisis, the US and many countries in the world are suffering acute shortages of modern ventilators to care for desperately ill patients. Since modern ICU ventilators are powerful devices that can deliver very high gas flow rates and pressures, multiple physicians have attempted to ventilate more than one patient on a single ventilator -- so-called 'vent splitting'. Early applications of this approach have utilized simple concatenations of ventilator tubing and T-pieces, to provide flow to more than one patient. Additional approaches using custom flow splitters -- sometimes made using 3D printing technologies -- have also advanced into the clinic with FDA approval. However, heretofore there has been less progress made on controlling individual ventilatory pressures for patients with severe lung disease. Given the inherent variability and instability of lung compliance amongst patients with COVID-19, there remains an important need to provide a means of extending ventilator usefulness to more than one patient, but in a way that provides more tailored pressures that can be titrated over time. In this descriptive report, we provide the basis for a ventilator circuit that can support two patients with individualized peak inspiratory and end-expiratory pressures. The circuit is comprised of exclusively 'off the shelf' materials and is inexpensive to produce. The circuit can be used with typical ICU ventilators, and with anesthesia ventilators used in operating rooms. Inspiratory and end-expiratory pressures for each patient can be titrated over time, without changes for one patient affecting the ventilation parameters of the other patient. Using in-line spirometry, individual tidal volumes can be measured for each patient. This Pressure-Regulated Ventilator Splitting (PReVentS) Yale University protocol operates under a pressure-control ventilatory mode, and may function optimally when patients are not triggering breaths from the ventilator. This method has been tested thus far only in the laboratory with mock lungs, and has not yet been deployed in animals or in patients. However, given the novelty and potential utility of this approach, we deemed it appropriate to provide this information to the broader critical care community at the present time. In coming days and weeks, we will continue to characterize and refine this approach, using large animal models and proof-of-principle human studies. url: http://medrxiv.org/cgi/content/short/2020.04.03.20052217v1?rss=1 doi: 10.1101/2020.04.03.20052217 id: cord-349958-126yb5se author: Raskin, Jo title: CANCER IN THE TIME OF COVID: Expert opinion on how to adapt current practice date: 2020-04-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The susceptibility of cancer patients to adverse outcome of viral infections is well known from past experiences, e.g. Influenza increasing the risk of hospital admission with respiratory distress four times, and the risk of death ten times, compared to patients without cancer [1]. url: https://doi.org/10.1183/13993003.00959-2020 doi: 10.1183/13993003.00959-2020 id: cord-009891-gqrhbhbn author: Rassool, G. Hussein title: Current issues and forthcoming events date: 2003-09-03 words: 3466.0 sentences: 168.0 pages: flesch: 49.0 cache: ./cache/cord-009891-gqrhbhbn.txt txt: ./txt/cord-009891-gqrhbhbn.txt summary: The Centers for Disease Control and Prevention (CDC), USA, reports that ''transmission to health care workers appears to have occurred after close contact with symptomatic individuals (e.g. persons with fever or respiratory symptoms) before recommended infection control precautions for SARS were implemented (i.e. unprotected exposures).'' There is also a possibility that the causative agent can remain viable for extended periods of time after drying on environmental surfaces. Preliminary results of a large-scale trial of a candidate AIDS vaccine announced by the US-based biotechnology company VaxGen suggest that it is possible to protect some individuals from HIV infection. The result is that poor diagnosis of pain in cancer patients remains a significant problem, with many physicians finding it difficult to differentiate between the various pain types; and, many underestimating its severity. Poor diagnosis, poor assessment, the choice of less appropriate treatments, plus patients and physicians fears about controlled drugs such as morphine all contribute to under treatment of cancer pain. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166755/ doi: 10.1046/j.1365-2648.2003.02701.x-i2 id: cord-005503-hm8tvkt3 author: Rasulo, Frank A. title: Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient date: 2020-03-24 words: 5987.0 sentences: 278.0 pages: flesch: 35.0 cache: ./cache/cord-005503-hm8tvkt3.txt txt: ./txt/cord-005503-hm8tvkt3.txt summary: Recently, automated infrared pupillometry has been introduced into clinical practice, quickly gaining popularity due to its quantitative precision, low cost, noninvasiveness, bedside applicability, and easy-to-use technology, contributing to a modern precision-oriented approach to medicine. reported that power mode transcranial Doppler had high sensitivity and specificity for diagnosis of brain death, respectively 100% and 98% (flow velocity was assessed in the middle cerebral artery using a transtemporal approach) [32] (Fig. 9 ). Processed EEG was originally intended for the management of the anesthetic state during surgery to avoid accidental awareness and to titrate sedation in critically ill patients where clinical scales represent the gold standard. In addition, clinical scale assessment is performed by disturbing sedated or sleeping patients (processed EEG does not require modification of the sedation state) and can never identify phases of burst suppression or isoelectric traces (total suppression) [39] , which are associated with negative outcomes (e.g., delirium occurrence, prolonged mechanical ventilation, mortality). abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092614/ doi: 10.1186/s13054-020-2781-2 id: cord-306149-sd0s0jup author: Ratanarat, Ranistha title: Critical Care Management of Patients with COVID-19: Early Experience in Thailand date: 2020-05-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Since late December 2019, the world has been challenged with an outbreak of COVID-19. In Thailand, an upper middle–income country with a limited healthcare infrastructure and restricted human resources, nearly 3,000 confirmed COVID-19 cases have been reported as of early May 2020. Public health policies aimed at preventing new COVID-19 cases were very effective in halting the pandemic in Thailand. Case fatality in Thailand has been low (1.7%), at least in part due to early stratification according to risk of disease severity and timely initiation of supportive care with affordable measures. We present our initial experience with COVID-19 in Thailand, focusing on several aspects that may have played a crucial role in curtailment of the pandemic, and elements of care for severely ill COVID-19 patients, including stratification, isolation, and affordable diagnostic approaches and supportive care measures. We also discuss local considerations concerning some proposed experimental treatments. url: https://www.ncbi.nlm.nih.gov/pubmed/32431287/ doi: 10.4269/ajtmh.20-0442 id: cord-216974-0al3vdh1 author: Ravaud, Philippe title: Reconfiguring health services to reduce the workload of caregivers during the COVID-19 outbreak using an open-source scalable platform for remote digital monitoring and coordination of care in hospital Command Centres date: 2020-03-12 words: 1459.0 sentences: 90.0 pages: flesch: 52.0 cache: ./cache/cord-216974-0al3vdh1.txt txt: ./txt/cord-216974-0al3vdh1.txt summary: title: Reconfiguring health services to reduce the workload of caregivers during the COVID-19 outbreak using an open-source scalable platform for remote digital monitoring and coordination of care in hospital Command Centres Patients answer simple self-reported questionnaires and their data is transmitted, in real time, to a Command Centre in the nearest reference hospital. Data from remote monitoring of patients are transmitted to a Command Centre, in the nearest reference hospital, and automated algorithms triage patients with early warning signs. Patients with confirmed Covid-19 are assessed by clinicians (in hospital or in community) for: 1) absence of initial signs of severity (based on their age, comorbidities, initial presentation of the disease); 2) their ability to be quarantined at home (e.g., absence of a psychiatric disorder or of a loss of autonomy); and 3) their ability to perform the remote monitoring at home (e.g., basic computer literacy, smartphone availability). abstract: The Covid-19 outbreak threatens to saturate healthcare systems in most Western countries. We describe how digital technologies may be used to automatically and remotely monitor patients at home. Patients answer simple self-reported questionnaires and their data is transmitted, in real time, to a Command Centre in the nearest reference hospital. Patient reported data are automatically filtered by algorithms to identify those with early warning signs. Open-source code of all software components required to deploy the remote digital monitoring platform and Command Centres is available. url: https://arxiv.org/pdf/2003.05873v1.pdf doi: nan id: cord-276132-tv5y1eqc author: Ray, Upasana title: COVID-19: The Impact in Oncology Care date: 2020-10-23 words: 5696.0 sentences: 243.0 pages: flesch: 39.0 cache: ./cache/cord-276132-tv5y1eqc.txt txt: ./txt/cord-276132-tv5y1eqc.txt summary: The COVID-19 pandemic has imposed a critical challenge to the current oncology care and practices including late diagnoses, delayed anti-cancer treatment, and static clinical trials. Delaying anti-cancer treatment in the ongoing pandemic cannot be recommended as a sensible choice to reduce the associated infection risk in patients. The American Society of Clinical Oncology (ASCO) recommends that in cancer patients diagnosed with the infection, the immunosuppressive therapies should be withheld until the symptoms resolve like complete remission of fever without use of antipyretics along with a negative COVID-19 test. Nevertheless, contact limitation and physical distancing guidelines continue to be an important part of the cancer treatment strategies during the pandemic in order to protect the patients, health-care personnel and non-COVID-19 patients being treated in the same organization. A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan abstract: The COVID-19 pandemic has imposed a critical challenge to the current oncology care and practices including late diagnoses, delayed anti-cancer treatment, and static clinical trials. With the increasing risk of cancer patients acquiring infection during receiving the essential care, the debate ensues on how to balance the risk factors and benefits out of the oncologic emergencies in cancer patients. In this review article, we have focused on the current global re-organization of the integrity and effectiveness of the treatment modalities depending on the patient and cancer-specific urgencies while minimizing exposure to the infection. In this review, we addressed how the worldwide oncology community is united to share therapy schemes and the best possible guidelines to help cancer patients, and to strategize and execute therapy/trial protocols. This review provides collective knowledge on the current re-structuring of the general framework that prioritizes cancer care with the available exploitation of the reduced resources and most importantly the unparalleled levels of companionship as a large health care community towards the need to offer the best possible care to the patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33134842/ doi: 10.1007/s42399-020-00592-7 id: cord-289542-u86ujtur author: Razavian, Narges title: A validated, real-time prediction model for favorable outcomes in hospitalized COVID-19 patients date: 2020-10-06 words: 8068.0 sentences: 379.0 pages: flesch: 45.0 cache: ./cache/cord-289542-u86ujtur.txt txt: ./txt/cord-289542-u86ujtur.txt summary: Here, we use 3345 retrospective and 474 prospective hospitalizations to develop and validate a parsimonious model to identify patients with favorable outcomes within 96 h of a prediction, based on real-time lab values, vital signs, and oxygen support variables. In this article, we describe how a collaboration among data scientists, electronic health record (EHR) programmers (vendorand health system-based), clinical informaticians, frontline physicians, and clinical leadership led to the development, prospective validation, and implementation of a machine learning model for real-time prediction of favorable outcomes within a 96 h window among hospitalized COVID-19 patients. Our approach differs from prior work in that we: (1) predict favorable outcomes (as opposed to adverse outcomes), (2) use a large COVID-19 patient cohort admitted across our hospitals, (3) design a model that can easily be extended to other institutions, (4) prospectively validate performance, and (5) integrate our model in the EHR to provide a real-time clinical decision support tool. abstract: The COVID-19 pandemic has challenged front-line clinical decision-making, leading to numerous published prognostic tools. However, few models have been prospectively validated and none report implementation in practice. Here, we use 3345 retrospective and 474 prospective hospitalizations to develop and validate a parsimonious model to identify patients with favorable outcomes within 96 h of a prediction, based on real-time lab values, vital signs, and oxygen support variables. In retrospective and prospective validation, the model achieves high average precision (88.6% 95% CI: [88.4–88.7] and 90.8% [90.8–90.8]) and discrimination (95.1% [95.1–95.2] and 86.8% [86.8–86.9]) respectively. We implemented and integrated the model into the EHR, achieving a positive predictive value of 93.3% with 41% sensitivity. Preliminary results suggest clinicians are adopting these scores into their clinical workflows. url: https://doi.org/10.1038/s41746-020-00343-x doi: 10.1038/s41746-020-00343-x id: cord-312677-rwznqiib author: Razmi, Mahdieh title: Immunomodulatory-Based Therapy as a Potential Promising Treatment Strategy against Severe COVID-19 Patients: A Systematic Review date: 2020-08-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The global panic of the novel coronavirus disease 2019 (COVID-19) triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent requirement for effective therapy. COVID-19 infection, especially in severely ill patients, is likely to be associated with immune dysregulation, prompting the development of novel treatment approaches. Therefore, this systematic review was designed to assess the available data regarding the efficacy of the immunomodulatory drugs used to manage COVID-19. A systematic literature search was carried out up to May 27, 2020, in four databases (PubMed, Scopus, Web of Science, and Embase) and also Clinicaltrials.gov. Sixty-six publications and 111 clinical trials were recognized as eligible, reporting the efficacy of the immunomodulatory agents, including corticosteroids, hydroxychloroquine, passive and cytokine-targeted therapies, mesenchymal stem cells, and blood-purification therapy, in COVID-19 patients. The data were found to be heterogeneous, and the clinical trials were yet to post any findings. Medicines were found to regulate the immune system by boosting the innate responses or suppressing the inflammatory reactions. Passive and cytokine-targeted therapies and mesenchymal stem cells were mostly safe and could regulate the disease much better. These studies underscored the significance of severity profiling in COVID-19 patients, along with appropriate timing, duration, and dosage of the therapies. Therefore, this review indicates that immunomodulatory therapies are potentially effective for COVID-19 and provides comprehensive information for clinicians to fight this outbreak. However, there is no consensus on the optimal therapy for COVID-19, reflecting that the immunomodulatory therapies still warrant further investigations. url: https://www.ncbi.nlm.nih.gov/pubmed/32896750/ doi: 10.1016/j.intimp.2020.106942 id: cord-315249-yclnl87n author: Read, R. C. title: Infection in acute exacerbations of chronic bronchitis: a clinical perspective date: 1999-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Acute exacerbations of chronic bronchitis (AECB) is an important cause of death and morbidity in developed countries and also has significant economic impact. The disease is characterized by increased dyspnoea, sputum volume and sputum purulence; the most commonly associated pathogens are Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis. H. influenzae and S. pneumoniae express virulence determinants that directly and indirectly impair mucociliary clearance and incite other consequences that are permissive to microbial persistence. Regarding the use of antibiotics, there is currently a lack of large-scale clinical trials that are sufficiently powerful to provide good evidence-based information. Nonetheless, antimicrobial chemotherapy has repeatedly been shown to confer benefit in patients with moderately severe features of AECB. Simple clinical criteria can be used to identify patients in whom there is a higher likelihood of treatment failure or mortality during AECB. These include significant cardiopulmonary co-morbidity, frequent exacerbations, advanced decline in lung function, malnutrition or other generalized debility, advanced age (> 70 years) and concurrent treatment with corticosteroids. In such patients, an aggressive antimicrobial approach to AECB may be warranted in order to prevent clinical failure or representation. From a clinical perspective, appropriate drugs include those that are stable to β-lactamases, are bactericidal against causative pathogens, penetrate diseased lung tissue in high concentrations and have a good safety profile. url: https://api.elsevier.com/content/article/pii/S0954611199900483 doi: 10.1016/s0954-6111(99)90048-3 id: cord-350437-dq1il88y author: Reale, Maria Lucia title: SARS-CoV-2 Infection in Cancer Patients: A Picture of an Italian Onco-Covid Unit date: 2020-08-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: The world, and Italy on the front lines, has experienced a major medical emergency due to the novel coronavirus outbreak. Cancer patients are one of the potentially most vulnerable cohorts of people, but data about their management are still few. Patients and Methods: In this monocentric retrospective study we included all SARS-CoV-2 oncological patients accepted, between March 27th and April 19th 2020, at the Onco-COVID Unit at San Luigi Gonzaga Hospital, one of the few Italian oncological-COVID wards. Data were obtained from medical records. Results: Eighteen cancer patients with COVID-19 were included. The mean (±SD) age of patients was 67 ± 14 years, 89% were men. Seven (39%) developed infection in communities and 11 (61%) during hospitalization. Lung cancer was the most frequent type of cancer (10, 56%). Seven patients (39%) were symptomatic for COVID-19 at the time of diagnosis and symptoms began 2 (±2) days before. The most common were shortness of breath and diarrhea. Fever was present in 5 patients (28%). Among the 11 asymptomatic patients, 8 (73%) became symptomatic during the hospitalization (mean time of symptoms onset 4 days ±4). Six patients (33%) were on active anti-tumor treatment: 2 (33%) received anti-tumor therapy within 2 weeks before the infection diagnosis and 2 (33%) continued oncological treatment after SARS-CoV-2 positivity. Eight (44%) patients died within a mean of 12 days (±8) from the infection diagnosis. Conclusions: Our series confirms the high mortality among cancer patients with COVID-19. The presence of asymptomatic cases evidences that typical symptoms and fever are not the only parameters to suspect the infection. The Onco-Covid unit suggests the importance of a tailored and holistic approach, even in this difficult situation. url: https://doi.org/10.3389/fonc.2020.01722 doi: 10.3389/fonc.2020.01722 id: cord-351722-3mw1te94 author: Recalde, M. title: Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: COVID-19 may differentially impact people with obesity. We aimed to describe and compare the demographics, comorbidities, and outcomes of obese patients with COVID-19 to those of non-obese patients with COVID-19, or obese patients with seasonal influenza. Methods: We conducted a cohort study based on outpatient/inpatient care, and claims data from January to June 2020 from the US, Spain, and the UK. We used six databases standardized to the OMOP common data model. We defined two cohorts of patients diagnosed and/or hospitalized with COVID-19. We created corresponding cohorts for patients with influenza in 2017-2018. We followed patients from index date to 30 days or death. We report the frequency of socio-demographics, prior comorbidities, and 30-days outcomes (hospitalization, events, and death) by obesity status. Findings: We included 627 044 COVID-19 (US: 502 650, Spain: 122 058, UK: 2336) and 4 549 568 influenza (US: 4 431 801, Spain: 115 224, UK: 2543) patients. The prevalence of obesity was higher among hospitalized COVID-19 (range: 38% to 54%) than diagnosed COVID-19 (30% to 47%), or diagnosed/hospitalized influenza (15% to 48%) patients. Obese hospitalized COVID-19 patients were more often female and younger than non-obese COVID-19 patients or obese influenza patients. Obese COVID-19 patients were more likely to have prior comorbidities, present with cardiovascular and respiratory events during hospitalization, require intensive services, or die compared to non-obese COVID-19 patients. Obese COVID-19 patients were also more likely to require intensive services or die compared to obese influenza patients, despite presenting with fewer comorbidities. Interpretation: We show that obesity is more common among COVID-19 than influenza patients, and that obese patients present with more severe forms of COVID-19 with higher hospitalization, intensive services, and fatality than non-obese patients. These data are instrumental for guiding preventive strategies of COVID-19 infection and complications url: https://doi.org/10.1101/2020.09.02.20185173 doi: 10.1101/2020.09.02.20185173 id: cord-290832-zmj59rc3 author: Recinella, Guerino title: Prognostic role of nutritional status in elderly patients hospitalized for COVID-19: a monocentric study date: 2020-10-08 words: 2985.0 sentences: 169.0 pages: flesch: 44.0 cache: ./cache/cord-290832-zmj59rc3.txt txt: ./txt/cord-290832-zmj59rc3.txt summary: AIMS: To assess the role of nutritional status as an independent prognostic factor for in-hospital death in elderly patients. At univariate analysis, age (HR 1.045 [CI 1.008–1.082]), cognitive impairment (HR 1.949 [CI 1.045–3.364]), C-reactive protein (HR 1.004 [CI 1.011–1.078]), lactate dehydrogenases (HR 1.003 [CI 1.001–1.004]) and GNRI moderate–severe risk category (HR 8.571 [CI 1.096–67.031]) were risk factors for in-hospital death, while albumin (HR 0.809 [CI 0.822–0.964]), PaO(2)/FiO(2) ratio (HR 0.996 [CI 0.993–0.999]) and body mass index (HR 0.875 [CI 0.782–0.979]) were protective factors. The main result of our study is that impaired nutritional status, assessed by the GNRI, together with the PaO 2 /FiO 2 ratio, is an independent predictor of in-hospital mortality in elderly patients with symptomatic SARS-CoV-2 infection. Future larger and multicentric studies are needed to validate our results on the prognostic value of GNRI in predicting in-hospital death and to further explore the role of other nutritional parameters in elderly patients hospitalized for COVID-19. abstract: BACKGROUND: Symptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection incidence is higher in the elderly patients. Pre-existing geriatric conditions such as comorbidity and frailty seem related to worse hospital outcomes. AIMS: To assess the role of nutritional status as an independent prognostic factor for in-hospital death in elderly patients. METHODS: Consecutive elderly patients (age > 65 years) hospitalized for novel coronavirus disease (COVID-19) were enrolled. Demographics, laboratory and comorbidity data were collected. Nutritional status was evaluated using the Geriatric Nutritional Risk Index (GNRI). Uni- and multivariate Cox regression analyses to evaluate predictors for in-hospital death were performed. RESULTS: One hundred and nine hospitalized elderly patients (54 male) were consecutively enrolled. At univariate analysis, age (HR 1.045 [CI 1.008–1.082]), cognitive impairment (HR 1.949 [CI 1.045–3.364]), C-reactive protein (HR 1.004 [CI 1.011–1.078]), lactate dehydrogenases (HR 1.003 [CI 1.001–1.004]) and GNRI moderate–severe risk category (HR 8.571 [CI 1.096–67.031]) were risk factors for in-hospital death, while albumin (HR 0.809 [CI 0.822–0.964]), PaO(2)/FiO(2) ratio (HR 0.996 [CI 0.993–0.999]) and body mass index (HR 0.875 [CI 0.782–0.979]) were protective factors. Kaplan–Meier survival curves showed a significative higher survival in patients without GNRI moderate or severe risk category (p = 0.0013). At multivariate analysis, PaO(2)/FiO(2) ratio (HR 0.993 [CI 0.987–0.999], p = 0.046) and GNRI moderate–severe risk category (HR 9.285 [1.183–72.879], p = 0.034) were independently associated with in-hospital death. CONCLUSION: Nutritional status assessed by GNRI is a significative predictor of survival in elderly patients hospitalized for COVID-19. The association between GNRI and PaO(2)/FiO(2) ratio is a good prognostic model these patients. url: https://doi.org/10.1007/s40520-020-01727-5 doi: 10.1007/s40520-020-01727-5 id: cord-255037-i9guxtix author: Reda, Gianluigi title: Reply to “CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report” Analysis of six hematological centers in Lombardy: On behalf of CLL commission of Lombardy Hematology Network (REL) date: 2020-08-04 words: 1177.0 sentences: 62.0 pages: flesch: 40.0 cache: ./cache/cord-255037-i9guxtix.txt txt: ./txt/cord-255037-i9guxtix.txt summary: The authors also refer to the recent recommendations for the management of cancer patients in COVID era published by the EHA Infectious Disease Scientific Working Group Executive Committee. On the one hand, CLL is associated with a disease-related disruption of both humoral and cell-mediated immunity, on the other hand, patient-related factors such as age, disease stage, and type of treatment received play an important role [6] . Ibrutinib, an irreversible inhibitor of Bruton''s tyrosine kinase (Btk) currently represents a milestone in the treatment of CLL and has been approved by FDA for the treatment of several B-cell malignancies and chronic graft-versus-host disease (cGVHD). Among 2902 CLL patients, 23 cases of COVID infections have been reported with molecular testing for SARS-CoV-2. In addition to its role on Btk, ibrutinib shows off-target inhibiting activity on IL-2-inducible T-cell kinase (Itk) and is thus capable of rebalancing the disease-inherent Th1/Th2 unbalance toward a Th1 phenotype in CLL patients. CLL and COVID-19 at the hospital clinic of Barcelona: an interim report abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32753689/ doi: 10.1038/s41375-020-0966-y id: cord-299333-qu0bmov5 author: Reddy, Gireesh B. title: Clinical Characteristics and Multisystem Imaging Findings of COVID-19: An Overview for Orthopedic Surgeons date: 2020-08-17 words: 4412.0 sentences: 235.0 pages: flesch: 37.0 cache: ./cache/cord-299333-qu0bmov5.txt txt: ./txt/cord-299333-qu0bmov5.txt summary: Since December 2019, infections with severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), a novel betacoronavirus strain responsible for coronavirus disease 2019 (COVID19) , rapidly progressed from an isolated cluster of cases in the Hubei province of east central China to a pandemic, with significant global health and economic repercussions [4, 5, 10, 24, 25, 27, 28, 44, 58, 80, 91] . Early reports from Italy and China indicated that although pulmonary diseases including ARDS and diffuse pneumonia comprise the predominant lethal complications of COVID-19, patients have also presented with or developed significant cardiac signs and symptoms [50] . COVID-19 musculoskeletal and neurologic manifestations are being reported with increased frequency, particularly in patients with more severe respiratory disease, indicating coronavirus neurotropism possibly directly related with higher viral loads, which are now detectable in cerebrospinal fluid [20] . abstract: The COVID-19 pandemic holds widespread implications for global public health, economies, societies, and the practice of orthopedic surgery. As our knowledge of the transmissibility of SARS-CoV-2 and the symptomatology and management of COVID-19 expands, orthopedic surgeons must remain up to date on the latest medical evidence and surgical perspectives. While COVID-19 primarily manifests with pulmonary symptoms, cardiovascular, neurologic, and other major organ systems may also be affected and present with hallmark imaging findings. This article reviews initial and emerging literature on clinical characteristics and imaging findings of COVID-19. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11420-020-09775-3) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s11420-020-09775-3 doi: 10.1007/s11420-020-09775-3 id: cord-272318-8yfg1j0o author: Reddy, Sujan T. title: Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series date: 2020-06-11 words: 3392.0 sentences: 197.0 pages: flesch: 41.0 cache: ./cache/cord-272318-8yfg1j0o.txt txt: ./txt/cord-272318-8yfg1j0o.txt summary: To further characterize cerebrovascular disease (CVD) in COVID-19, we review the current literature of published cases and additionally report the clinical presentation, laboratory and diagnostic testing results of 12 cases with COVID-19 infection and concurrent CVD from two academic medical centers in Houston, TX, USA, between March 1 and May 10, 2020. To date, few studies have reported cerebrovascular complications in COVID-19 [3, 4] and 4 small case series have described the clinical and laboratory findings in patients with COVID-19 and concurrent stroke [5] [6] [7] [8] . We review the current literature of published cases and describe our experience of 12 cases with COVID-19 infection and concurrent cerebrovascular disease (CVD) to highlight the clinical presentation and proposed mechanisms of central nervous system (CNS) involvement by SARS-CoV-2. Additionally, we performed a retrospective chart review of all hospitalized cases with confirmed COVID-19 infection (SARS-CoV-2 RT-PCR positive) and CVD (ischemic and hemorrhagic stroke) between March 1 and May 10, 2020 seen at two comprehensive stroke centers in Houston, TX, USA. abstract: COVID-19 has been associated with a hypercoagulable state causing cardiovascular and neurovascular complications. To further characterize cerebrovascular disease (CVD) in COVID-19, we review the current literature of published cases and additionally report the clinical presentation, laboratory and diagnostic testing results of 12 cases with COVID-19 infection and concurrent CVD from two academic medical centers in Houston, TX, USA, between March 1 and May 10, 2020. To date, there are 12 case studies reporting 47 cases of CVD in COVID-19. However, only 4 small case series have described the clinical and laboratory findings in patients with COVID-19 and concurrent stroke. Viral neurotropism, endothelial dysfunction, coagulopathy and inflammation are plausible proposed mechanisms of CVD in COVID-19 patients. In our case series of 12 patients, 10 patients had an ischemic stroke, of which 1 suffered hemorrhagic transformation and two had intracerebral hemorrhage. Etiology was determined to be embolic without a clear cause identified in 6 ischemic stroke patients, while the remaining had an identifiable source of stroke. The majority of the patients had elevated inflammatory markers such as D-dimer and interleukin-6. In patients with embolic stroke of unclear etiology, COVID-19 may have played a direct or indirect role in the processes that eventually led to the strokes while in the remaining cases, it is unclear if infection contributed partially or was an incidental finding. url: https://www.ncbi.nlm.nih.gov/pubmed/32647526/ doi: 10.1159/000508958 id: cord-348364-jb0lvhq5 author: Rehman, Tyler title: Spontaneous Pneumothorax in an Elderly Patient With Coronavirus Disease (COVID-19) Pneumonia date: 2020 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: The relationship between the 2019 novel coronavirus (COVID-19) and pneumothorax is not yet established. As of June 2020, few cases of nonintubated patients developing pneumothorax had been documented. Case Report: We present the case of an elderly patient with COVID-19 pneumonia that resulted in a prolonged hospital course because of pneumothorax complication. The patient did not develop severe symptoms and did not require intubation. Conclusion: This case report should aid clinicians assessing patients with COVID-19 pneumonia. url: https://doi.org/10.31486/toj.20.0072 doi: 10.31486/toj.20.0072 id: cord-005481-00rezmqj author: Reid, T title: Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial date: 2001-11-22 words: 6637.0 sentences: 355.0 pages: flesch: 44.0 cache: ./cache/cord-005481-00rezmqj.txt txt: ./txt/cord-005481-00rezmqj.txt summary: [21] [22] [23] Tumor-selective viral replication and necrosis were demonstrated, and the treatment was well-tolerated without dose-limiting toxicities; flu-like symptoms and injection site pain were frequently noted. [24] [25] [26] [27] While all recurrent head and neck cancer patients on the combination viral and chemo-therapy clinical trial received intravenous chemotherapy (cisplatin and 5-fluorouracil), the response rate of tumors injected with ONYX-015 was significantly higher than in tumors that were not injected. Therefore, based on the favorable clinical toxicity and efficacy profile with intratumoral injection, and preclinical efficacy following intravascular administration, we performed a phase I/II dose escalation trial of ONYX-015 administered via the hepatic artery to patients with metastatic gastrointestinal carcinomas (primarily colorectal) to the liver. We performed a phase I dose-escalation trial of the replication-selective adenovirus ONYX-015 administered by hepatic arterial infusion, alone and in combination with intravenous 5-FU and LV, in patients with liver metastases from gastrointestinal carcinomas. abstract: Both replication-incompetent and replication-selective adenoviruses are being developed for the treatment of cancer and other diseases. Concerns have been raised about the safety of intra-vascular adenovirus administration following a patient death on a clinical trial with a replication-defective adenovirus. In addition, the feasibility of vascular delivery to distant tumors has been questioned. dl1520 (ONYX-015) is a replication-selective adenovirus that has previously shown safety and antitumoral activity following intratumoral injection. This is the first report of intra-vascular administration with a genetically engineered, replication-selective virus. A phase I dose-escalation trial was performed in patients with liver-predominant gastrointestinal carcinoma (n = 11 total; primarily colorectal). dl1520 was infused into the hepatic artery at doses of 2 × 10(8)–2 × 10(12) particles for two cycles (days 1 and 8). Subsequent cycles of dl1520 were administered in combination with intravenous 5-fluorouracil (5-FU) and leucovorin. No dose-limiting toxicity, maximally tolerated dose or treatment-emergent clinical hepatotoxicity were identified following dl1520 infusion. Mild to moderate fever, rigors and fatigue were the most common adverse events. Antibody titers increased significantly in all patients. Viral replication was detectable in patients receiving the highest two doses. An objective response was demonstrated in combination with chemotherapy in a patient who was refractory to both 5-FU and dl1520 as single agents. Therefore, hepatic artery infusion of the attenuated adenovirus dl1520 was well-tolerated at doses resulting in infection, replication and chemotherapy-associated antitumoral activity. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092315/ doi: 10.1038/sj.gt.3301512 id: cord-316522-fbw9x3ik author: Reiss, Allison B. title: A Telemedicine Approach to Covid-19 Assessment and Triage date: 2020-09-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Covid-19 is a new highly contagious RNA viral disease that has caused a global pandemic. Human-to-human transmission occurs primarily through oral and nasal droplets and possibly through the airborne route. The disease may be asymptomatic or the course may be mild with upper respiratory symptoms, moderate with non-life-threatening pneumonia, or severe with pneumonia and acute respiratory distress syndrome. The severe form is associated with significant morbidity and mortality. While patients who are unstable and in acute distress need immediate in-person attention, many patients can be evaluated at home by telemedicine or videoconferencing. The more benign manifestations of Covid-19 may be managed from home to maintain quarantine, thus avoiding spread to other patients and health care workers. This document provides an overview of the clinical presentation of Covid-19, emphasizing telemedicine strategies for assessment and triage of patients. Advantages of the virtual visit during this time of social distancing are highlighted. url: https://www.ncbi.nlm.nih.gov/pubmed/32927589/ doi: 10.3390/medicina56090461 id: cord-000161-hxjxczyr author: Rello, Jordi title: Clinical review: Primary influenza viral pneumonia date: 2009-12-21 words: 3652.0 sentences: 195.0 pages: flesch: 35.0 cache: ./cache/cord-000161-hxjxczyr.txt txt: ./txt/cord-000161-hxjxczyr.txt summary: Primary influenza pneumonia has a high mortality rate during pandemics, not only in immunocompromised individuals and patients with underlying comorbid conditions, but also in young healthy adults. Pneumonia and the acute respiratory distress syndrome (ARDS) account for the majority of severe morbidity and mortality that accompany pandemic influenza infection [14] . A recent analysis of lung specimens from 77 fatal cases of pandemic H1N1v 2009 infection found a prevalence of concurrent bacterial pneumonia in 29% of these patients [31] . A recent World Health Organization treatment guideline for pharmacological management of 2009 pandemic H1N1v influenza A recommends the consideration of higher doses of oseltamivir (150 mg twice a day) and longer duration of treatment for patients with severe influenza pneumonia or clinical deterioration [44] . The rapid progression from initial typical influenza symptoms to extensive pulmonary involvement, with acute lung injury, can occur both in patients with underlying respiratory or cardiac morbidities and in young healthy adults, especially if obese or pregnant. abstract: Primary influenza pneumonia has a high mortality rate during pandemics, not only in immunocompromised individuals and patients with underlying comorbid conditions, but also in young healthy adults. Clinicians should maintain a high index of suspicion for this diagnosis in patients presenting with influenza-like symptoms that progress quickly (2 to 5 days) to respiratory distress and extensive pulmonary involvement. The sensitivity of rapid diagnostic techniques in identifying infections with the pandemic 2009 H1N1v influenza strain is currently suboptimal. The most reliable real-time reverse transcriptase-polymerase chain reaction molecular testing is available in limited clinical settings. Despite 6 months of pandemic circulation, most novel H1N1v pandemic strains remain susceptible to oseltamivir. Ensuring an appropriate oxygenation and ventilation strategy, as well as prompt initiation of antiviral therapy, is essential in management. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811908/ doi: 10.1186/cc8183 id: cord-276303-lgywz9ea author: Rello, Jordi title: COVID-19, steroids and other immunomodulators: The jigsaw is not complete date: 2020-10-25 words: 1627.0 sentences: 80.0 pages: flesch: 46.0 cache: ./cache/cord-276303-lgywz9ea.txt txt: ./txt/cord-276303-lgywz9ea.txt summary: Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2352556820302435?v=s5 doi: 10.1016/j.accpm.2020.10.011 id: cord-280060-gzby85u9 author: Rello, Jordi title: Management of infections in critically ill returning travellers in the intensive care unit—II: clinical syndromes and special considerations in immunocompromised patients() date: 2016-04-28 words: 5493.0 sentences: 297.0 pages: flesch: 38.0 cache: ./cache/cord-280060-gzby85u9.txt txt: ./txt/cord-280060-gzby85u9.txt summary: 2 A International Journal of Infectious Diseases 48 (2016) 104-112 significant number of immunocompromised patients may also be migrants who may return to their countries of origin to visit friends and relatives, and may acquire travel-associated infections. 26 Cases of Chagas disease (Trypanosoma cruzi) either as a consequence of reactivation of a latent infection not identified at the time of transplant (because an unrecorded travel history or stay in an endemic area) or by transmission through the organ donor, can also be associated with a high mortality. There have also been case reports of severe disease from other travel-associated infections, such as salmonellosis, Vibrio parahaemolyticus, and visceral leishmaniasis in immunocompromised patients. Less common pathogens such as Staphylococcus aureus, avian influenza viruses such as H7N9 and H5N1, the Middle East respiratory syndrome coronavirus (MERS-CoV), and Gram-negative rods such as Burkholderia pseudomallei must also be considered, as well as a few other pathogens that do not usually cause pneumonia, such as malaria. abstract: This position paper is the second ESCMID Consensus Document on this subject and aims to provide intensivists, infectious disease specialists, and emergency physicians with a standardized approach to the management of serious travel-related infections in the intensive care unit (ICU) or the emergency department. This document is a cooperative effort between members of two European Society of Clinical Microbiology and Infectious Diseases (ESCMID) study groups and was coordinated by Hakan Leblebicioglu and Jordi Rello for ESGITM (ESCMID Study Group for Infections in Travellers and Migrants) and ESGCIP (ESCMID Study Group for Infections in Critically Ill Patients), respectively. A relevant expert on the subject of each section prepared the first draft which was then edited and approved by additional members from both ESCMID study groups. This article summarizes considerations regarding clinical syndromes requiring ICU admission in travellers, covering immunocompromised patients. url: https://doi.org/10.1016/j.ijid.2016.04.020 doi: 10.1016/j.ijid.2016.04.020 id: cord-287515-oe7adj91 author: Rello, Jordi title: Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China date: 2020-03-03 words: 1381.0 sentences: 76.0 pages: flesch: 44.0 cache: ./cache/cord-287515-oe7adj91.txt txt: ./txt/cord-287515-oe7adj91.txt summary: Prior experience with viral pneumonia, including influenza and MERS-coronavirus, suggest that steroids can contribute to higher mortality, increase viral replication with longer periods of viral clearance and more superinfections (including invasive pulmonary aspergillosis, as already reported in the Wuhan cohort) [5, 6] . Another difference is that most COVID-19 infected patients were diagnosed with viral pneumonia, whereas acute exacerbations of COPD or bronchospasm or myocarditis were more common in influenza. Use of noninvasive ventilation is controversial, showing limited efficacy in MERS and is associated with very high levels of aerosol spread, exposing staff at much greater risk of infection [11, 12] . Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a singlecentered, retrospective, observational study High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A/H1N1 v abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32142972/ doi: 10.1016/j.accpm.2020.03.001 id: cord-299679-6z9e5gi6 author: Rello, Jordi title: Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers date: 2020-05-21 words: 1961.0 sentences: 112.0 pages: flesch: 37.0 cache: ./cache/cord-299679-6z9e5gi6.txt txt: ./txt/cord-299679-6z9e5gi6.txt summary: Many intubated patients present with phenotype 4, characterised by pulmonary hypoxic vasoconstriction, being associated with severe hypoxaemia with "normal" (>40 mL·cmH(2)O(−1)) lung compliance and likely representing pulmonary microvascular thrombosis. Phenotype 5 is often associated with high plasma procalcitonin and has low pulmonary compliance, Which is a result of co-infection or acute lung injury after noninvasive ventilation. The clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is broad, ranging from asymptomatic infection to flu-like illness (sometimes with digestive disturbances) to viral pneumonia. Phenotype 2 represents 80% of hospitalisations and is characterised by the presence of hypoxaemia or small opacities on chest radiographs and these patients should be referred for close respiratory monitoring ( particularly respiratory rate and oxygen saturation measure by pulse oximetry) because they are at risk of rapid deterioration progressing to death if intubation is not timely instituted. abstract: Patients with COVID-19 present a broad spectrum of clinical presentation. Whereas hypoxaemia is the marker of severity, different strategies of management should be customised to five specific individual phenotypes. Many intubated patients present with phenotype 4, characterised by pulmonary hypoxic vasoconstriction, being associated with severe hypoxaemia with “normal” (>40 mL·cmH(2)O(−1)) lung compliance and likely representing pulmonary microvascular thrombosis. Phenotype 5 is often associated with high plasma procalcitonin and has low pulmonary compliance, Which is a result of co-infection or acute lung injury after noninvasive ventilation. Identifying these clinical phenotypes and applying a personalised approach would benefit the optimisation of therapies and improve outcomes. url: https://www.ncbi.nlm.nih.gov/pubmed/32341111/ doi: 10.1183/13993003.01028-2020 id: cord-352065-960xqft4 author: Rello, Jordi title: Update in COVID-19 in the Intensive Care Unit from the 2020 HELLENIC Athens International Symposium date: 2020-10-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The 2020 International Web Scientific Event in COVID-19 pandemic in critically ill patients aimed at updating the information and knowledge on the COVID-19 pandemic in the intensive care unit. Experts reviewed the latest literature relating to the COVID-19 pandemic in critically ill patients, such as epidemiology, pathophysiology, phenotypes of infection, COVID-19 as a systematic infection, molecular diagnosis, mechanical ventilation, thromboprophylaxis, COVID-19 associated co-infections, immunotherapy, plasma treatment, Catheter-Related bloodstream infections, artificial intelligence for COVID-19, and vaccination. Antiviral therapy and co-infections are out of the scope of this review. In this review, each of these issues is discussed with key messages regarding management and further research being presented after a brief review of available evidence. url: https://www.ncbi.nlm.nih.gov/pubmed/33172592/ doi: 10.1016/j.accpm.2020.10.008 id: cord-320864-k9zksbyt author: Remes-Troche, J. M. title: Recommendations for the reopening and activity resumption of the neurogastroenterology units in the face of the COVID-19 pandemic. Position of the Sociedad Latinoamericana de Neurogastroenterología date: 2020-11-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID 19 pandemic has forced the establishment of measures to avoid contagion during diagnostic and therapeutic tests in gastroenterology. Gastrointestinal motility studies involve a high and intermediate risk of transmission of infection by this virus. Given its elective or non-urgent indication in most cases, we recommend deferring the performance of these tests until there is a significant control of the infection rate in each country, during the pandemic. When health authorities allow a return to normalcy and in the absence of effective treatment or a preventive vaccine for COVID 19 infection, we recommend a strict protocol to classify patients according to their infectious-contagious status through the appropriate use of tests to detect the virus and its immune response, as well as the use of protective measures to be followed by health personnel to avoid contagion during the performance of a gastrointestinal motility test. url: https://api.elsevier.com/content/article/pii/S2255534X2030092X doi: 10.1016/j.rgmxen.2020.07.004 id: cord-259747-sl9q63oc author: Remmelink, Myriam title: Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients date: 2020-08-12 words: 4541.0 sentences: 244.0 pages: flesch: 48.0 cache: ./cache/cord-259747-sl9q63oc.txt txt: ./txt/cord-259747-sl9q63oc.txt summary: BACKGROUND: Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients. IHC revealed positive cells with a heterogeneous distribution in the lungs of 11 of the 17 (65%) patients; RT-PCR yielded a wide distribution of SARS-CoV-2 in different tissues, with 8 patients showing viral presence in all tested organs (i.e., lung, heart, spleen, liver, colon, kidney, and brain). In this post-mortem study, we included the first 17 adult patients (> 18 years) who died in our hospital (either in a COVID-19 unit or an intensive care unit) from March 13, 2020, with confirmed SARS-CoV-2 infection (i.e., positive RT-PCR assay on nasopharyngeal swab and/or bronchoalveolar lavage specimen). This post-mortem study showed several histopathological abnormalities in COVID-19 non-survivors; however, none of the findings was specific for direct viral injury, even though SARS-CoV-2 was detected in all examined organs using RT-PCR. abstract: BACKGROUND: Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients. METHODS: We evaluated whether some specific post-mortem features are observed in these patients and if these changes are related to the presence of the virus in different organs. Complete macroscopic and microscopic autopsies were performed on different organs in 17 COVID-19 non-survivors. Presence of SARS-CoV-2 was evaluated with immunohistochemistry (IHC) in lung samples and with real-time reverse-transcription polymerase chain reaction (RT-PCR) test in the lung and other organs. RESULTS: Pulmonary findings revealed early-stage diffuse alveolar damage (DAD) in 15 out of 17 patients and microthrombi in small lung arteries in 11 patients. Late-stage DAD, atypical pneumocytes, and/or acute pneumonia were also observed. Four lung infarcts, two acute myocardial infarctions, and one ischemic enteritis were observed. There was no evidence of myocarditis, hepatitis, or encephalitis. Kidney evaluation revealed the presence of hemosiderin in tubules or pigmented casts in most patients. Spongiosis and vascular congestion were the most frequently encountered brain lesions. No specific SARS-CoV-2 lesions were observed in any organ. IHC revealed positive cells with a heterogeneous distribution in the lungs of 11 of the 17 (65%) patients; RT-PCR yielded a wide distribution of SARS-CoV-2 in different tissues, with 8 patients showing viral presence in all tested organs (i.e., lung, heart, spleen, liver, colon, kidney, and brain). CONCLUSIONS: In conclusion, autopsies revealed a great heterogeneity of COVID-19-associated organ injury and the remarkable absence of any specific viral lesions, even when RT-PCR identified the presence of the virus in many organs. url: https://www.ncbi.nlm.nih.gov/pubmed/32787909/ doi: 10.1186/s13054-020-03218-5 id: cord-272655-qeojdpez author: Remolina, Yuly Andrea title: Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia date: 2015-11-17 words: 4309.0 sentences: 204.0 pages: flesch: 42.0 cache: ./cache/cord-272655-qeojdpez.txt txt: ./txt/cord-272655-qeojdpez.txt summary: OBJECTIVES: To identify the viral aetiology in adult patients with severe acute respiratory infection (SARI) admitted to sentinel surveillance institutions in Bogotá in 2012. DESIGN: A cross-sectional study was conducted in which microarray molecular techniques for viral identification were used on nasopharyngeal samples of adult patients submitted to the surveillance system, and further descriptions of clinical features and relevant clinical outcomes, such as mortality, need for critical care, use of mechanical ventilation and hospital stay, were obtained. Under this initiative, countries have developed surveillance systems by following cases of influenza-like illness and severe acute respiratory infections (SARIs), which are clinically diagnosed among patients with fever, coughing or sore throat, difficulty breathing and the need for hospitalization [3] . In our study, viruses were identified as the most frequent causal agents of SARI requiring hospitalization in 2012, with most cases showing a high rate of viral co-infection, a high degree of morbidity, prolonged hospital stays and frequent needs for ICU management and mechanical ventilation. abstract: OBJECTIVES: To identify the viral aetiology in adult patients with severe acute respiratory infection (SARI) admitted to sentinel surveillance institutions in Bogotá in 2012. DESIGN: A cross-sectional study was conducted in which microarray molecular techniques for viral identification were used on nasopharyngeal samples of adult patients submitted to the surveillance system, and further descriptions of clinical features and relevant clinical outcomes, such as mortality, need for critical care, use of mechanical ventilation and hospital stay, were obtained. SETTING: Respiratory infections requiring hospital admission in surveillance centres in Bogotá, Colombia. PARTICIPANTS: Ninety-one adult patients with acute respiratory infection (55% were female). MEASUREMENTS: Viral identification, intensive care unit admission, hospital stay, and mortality. RESULTS: Viral identification was achieved for 63 patients (69.2%). Comorbidity was frequently identified and mainly involved chronic pulmonary disease or pregnancy. Influenza, Bocavirus and Adenovirus were identified in 30.8%, 28.6% and 18.7% of the cases, respectively. Admission to the intensive care unit occurred in 42.9% of the cases, while mechanical ventilation was required for 36.3%. The average hospital stay was 9.9 days, and mortality was 15.4%. Antibiotics were empirically used in 90.1% of patients. CONCLUSIONS: The prevalence of viral aetiology of SARI in this study was high, with adverse clinical outcomes, intensive care requirements and high mortality. url: https://doi.org/10.1371/journal.pone.0143152 doi: 10.1371/journal.pone.0143152 id: cord-253402-6sgeraws author: Remuzzi, Andrea title: COVID-19 and Italy: what next? date: 2020-03-13 words: 2847.0 sentences: 119.0 pages: flesch: 55.0 cache: ./cache/cord-253402-6sgeraws.txt txt: ./txt/cord-253402-6sgeraws.txt summary: There is now grave concern regarding the Italian national health system''s capacity to effectively respond to the needs of patients who are infected and require intensive care for SARS-CoV-2 pneumonia. At present, our national health system''s capacity to effectively respond to the needs of those who are already infected and require admission to an intensive care unit for ARDS, largely due to SARS-CoV-2 pneumonia, is a matter of grave concern. Given that the mortality of patients who are critically ill with SARS-CoV-2 pneumonia is high and that the survival time of non-survivors is 1-2 weeks, the number of people infected in Italy will probably impose a major strain on critical care facilities in our hospitals, some of which do not have adequate resources or staff to deal with this emergency. We predict that if the exponential trend continues for the next few days, more than 2500 hospital beds for patients in intensive care units will be needed in only 1 week to treat ARDS caused by SARS-CoV-2-pneumonia in Italy. abstract: The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already taken on pandemic proportions, affecting over 100 countries in a matter of weeks. A global response to prepare health systems worldwide is imperative. Although containment measures in China have reduced new cases by more than 90%, this reduction is not the case elsewhere, and Italy has been particularly affected. There is now grave concern regarding the Italian national health system's capacity to effectively respond to the needs of patients who are infected and require intensive care for SARS-CoV-2 pneumonia. The percentage of patients in intensive care reported daily in Italy between March 1 and March 11, 2020, has consistently been between 9% and 11% of patients who are actively infected. The number of patients infected since Feb 21 in Italy closely follows an exponential trend. If this trend continues for 1 more week, there will be 30 000 infected patients. Intensive care units will then be at maximum capacity; up to 4000 hospital beds will be needed by mid-April, 2020. Our analysis might help political leaders and health authorities to allocate enough resources, including personnel, beds, and intensive care facilities, to manage the situation in the next few days and weeks. If the Italian outbreak follows a similar trend as in Hubei province, China, the number of newly infected patients could start to decrease within 3–4 days, departing from the exponential trend. However, this cannot currently be predicted because of differences between social distancing measures and the capacity to quickly build dedicated facilities in China. url: https://www.sciencedirect.com/science/article/pii/S0140673620306279 doi: 10.1016/s0140-6736(20)30627-9 id: cord-285291-pep4opiq author: Remy, Kenneth E. title: Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists* date: 2020-04-29 words: 7168.0 sentences: 423.0 pages: flesch: 41.0 cache: ./cache/cord-285291-pep4opiq.txt txt: ./txt/cord-285291-pep4opiq.txt summary: T he worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has already resulted in critical care demands overwhelming resources in nations such as Italy (1) . Prone positioning for at least 12 hours daily in adults with severe ARDS may increase ventilator-free days, reduce in-hospital mortality, and reduce the need for rescue therapies like inhaled nitric oxide and extracorporeal membrane oxygenation (ECMO) (16, (65) (66) (67) (68) . Nonpharmacologic approaches to these modifiable risk factors include frequent environmental reorientation, cognitive stimulation, minimizing sleep interruptions, engaging familiar visitors, limiting use of sedative medications, and scheduled sedation "holidays." These strategies have consistently shown improved clinical outcomes in critically ill patients and are now considered standard of care (117) . EPVent-2 Study Group: Effect of titrating positive end-expiratory pressure (PEEP) with an esophageal pressure-guided strategy vs an empirical high PEEP-FIO 2 strategy on death and days free from mechanical ventilation among patients with acute respiratory distress syndrome: A randomized clinical trial abstract: In the midst of the severe acute respiratory syndrome coronavirus 2 pandemic, which causes coronavirus disease 2019, there is a recognized need to expand critical care services and beds beyond the traditional boundaries. There is considerable concern that widespread infection will result in a surge of critically ill patients that will overwhelm our present adult ICU capacity. In this setting, one proposal to add “surge capacity” has been the use of PICU beds and physicians to care for these critically ill adults. DESIGN: Narrative review/perspective. SETTING: Not applicable. PATIENTS: Not applicable. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The virus’s high infectivity and prolonged asymptomatic shedding have resulted in an exponential growth in the number of cases in the United States within the past weeks with many (up to 6%) developing acute respiratory distress syndrome mandating critical care services. Coronavirus disease 2019 critical illness appears to be primarily occurring in adults. Although pediatric intensivists are well versed in the care of acute respiratory distress syndrome from viral pneumonia, the care of differing aged adult populations presents some unique challenges. In this statement, a team of adult and pediatric-trained critical care physicians provides guidance on common “adult” issues that may be encountered in the care of these patients and how they can best be managed in a PICU. CONCLUSIONS: This concise scientific statement includes references to the most recent and relevant guidelines and clinical trials that shape management decisions. The intention is to assist PICUs and intensivists in rapidly preparing for care of adult coronavirus disease 2019 patients should the need arise. url: https://www.ncbi.nlm.nih.gov/pubmed/32420720/ doi: 10.1097/pcc.0000000000002429 id: cord-254446-yxqbe1dj author: Ren, Yunzhao R. title: A Comprehensive Updated Review on SARS‐CoV‐2 and COVID‐19 date: 2020-05-29 words: 6723.0 sentences: 426.0 pages: flesch: 49.0 cache: ./cache/cord-254446-yxqbe1dj.txt txt: ./txt/cord-254446-yxqbe1dj.txt summary: The disease name -COVID-19‖ and the associated virus name -SARS-CoV-2‖ were coined by the World Health Organization (WHO) and the Coronavirus Study Group of the International Committee on Virus Taxonomy, respectively, on February 11 1, 2 . Interestingly, pharyngeal swab viral nucleic acid screening results of 2,510 patients between January 23 and February 25 from a hospital fever clinic in Hunan Province (a neighboring province of Hubei) demonstrated that the positive rate of SARS-CoV-2 (1.3%) was lower than that of Influenza A (2.3%) and Influenza B (3.3%) 42 . Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial abstract: This literature review aims to provide a comprehensive current summary of the pathogenesis, clinical features, disease course, host immune responses, and current investigational antiviral and immunomodulatory pharmacotherapies, in order to facilitate the development of future therapies and measures for prevention and control. This article is protected by copyright. All rights reserved url: https://www.ncbi.nlm.nih.gov/pubmed/32469437/ doi: 10.1002/jcph.1673 id: cord-273587-nja58vxw author: Rendeiro, A. F. title: Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression date: 2020-09-09 words: 8910.0 sentences: 467.0 pages: flesch: 46.0 cache: ./cache/cord-273587-nja58vxw.txt txt: ./txt/cord-273587-nja58vxw.txt summary: By profiling mild and severe COVID-19 patients and healthy donors with flow cytometry, we demonstrate that SARS-CoV-2 is associated with broad dysregulation of the circulating immune system, characterized by the relative loss of lymphoid cells coupled to expansion of myeloid cells. While we observed no significant differences in the relative abundance of KIR receptors among COVID-19 patients with mild disease and healthy controls (Figure 3f) , a significantly higher proportion of cells expressed CD158i (NKG2A) in severe patients compared with mild or convalescent individuals. Despite the backdrop of a relative decrease in B cell numbers as disease progresses, we observed only a mild, non-significant increase in plasmacytoid cells in patients with severe COVID-19 compared with healthy donors (Figure 4a) . The resulting network of significant effects identified several clinical factors associated with specific immune cell populations, highlighting how age, sex, and disease severity jointly influence the circulating immune systems in patients with COVID-19 (Figure 6a) . abstract: With a rising incidence of COVID-19-associated morbidity and mortality worldwide, it is critical to elucidate the innate and adaptive immune responses that drive disease severity. We performed longitudinal immune profiling of peripheral blood mononuclear cells from 45 patients and healthy donors. We observed a dynamic immune landscape of innate and adaptive immune cells in disease progression and absolute changes of lymphocyte and myeloid cells in severe versus mild cases or healthy controls. Intubation and death were coupled with selected natural killer cell KIR receptor usage and IgM+ B cells and associated with profound CD4 and CD8 T cell exhaustion. Pseudo-temporal reconstruction of the hierarchy of disease progression revealed dynamic time changes in the global population recapitulating individual patients and the development of an eight-marker classifier of disease severity. Estimating the effect of clinical progression on the immune response and early assessment of disease progression risks may allow implementation of tailored therapies. url: http://medrxiv.org/cgi/content/short/2020.09.08.20189092v1?rss=1 doi: 10.1101/2020.09.08.20189092 id: cord-025164-hqj22yxe author: Renew, J. Ross title: Neuromuscular blockade management in the critically Ill patient date: 2020-05-24 words: 8188.0 sentences: 383.0 pages: flesch: 31.0 cache: ./cache/cord-025164-hqj22yxe.txt txt: ./txt/cord-025164-hqj22yxe.txt summary: ACh: Acetylcholine; AMG: Acceleromyography; ARDS: Acute respiratory distress syndrome; ASA: American Society of Anesthesiologists; CIM: Critical illness myopathy; CINM: Critical illness neuromyopathy; CIP: Critical illness polyneuropathy; DVT: Deep venous thrombosis; ED95: Effective dose that decreases the twitch by 95% from baseline; EEG: Electroencephalography; EMG: Electromyography; GRADE: Grading of Recommendations Assessment, Development, and Evaluation; ICP: Intracranial pressure; ICU: Intensive care unit; ICUAW: Intensive care unit-acquired weakness; KMG: Kinemyography; nAChR: Nicotinic acetylcholine receptors; NAP4: 4th National Audit Project; NMBA: Neuromuscular blocking agent; NMJ: Neuromuscular junction; OR: Operating room; OSA: Obstructive sleep apnea; PaO 2 /FiO 2 : Partial pressure of oxygen to fraction of inspired oxygen; pEEG: Processed electroencephalography; PNS: Peripheral nerve stimulator; RSII: Rapid sequence induction and intubation; SCCM: Society of Critical Care Medicine for all aspects of the work. abstract: Neuromuscular blocking agents (NMBAs) can be an effective modality to address challenges that arise daily in the intensive care unit (ICU). These medications are often used to optimize mechanical ventilation, facilitate endotracheal intubation, stop overt shivering during therapeutic hypothermia following cardiac arrest, and may have a role in the management of life-threatening conditions such as elevated intracranial pressure and status asthmaticus (when deep sedation fails or is not tolerated). However, current NMBA use has decreased during the last decade due to concerns of potential adverse effects such as venous thrombosis, patient awareness during paralysis, development of critical illness myopathy, autonomic interactions, and even residual paralysis following cessation of NMBA use. It is therefore essential for clinicians to be familiar with evidence-based practices regarding appropriate NMBA use in order to select appropriate indications for their use and avoid complications. We believe that selecting the right NMBA, administering concomitant sedation and analgesic therapy, and using appropriate monitoring techniques mitigate these risks for critically ill patients. Therefore, we review the indications of NMBA use in the critical care setting and discuss the most appropriate use of NMBAs in the intensive care setting based on their structure, mechanism of action, side effects, and recognized clinical indications. Lastly, we highlight the available pharmacologic antagonists, strategies for sedation, newer neuromuscular monitoring techniques, and potential complications related to the use of NMBAs in the ICU setting. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245849/ doi: 10.1186/s40560-020-00455-2 id: cord-004339-7nwpic3d author: Rennie, Katherine J. title: Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction date: 2020-02-13 words: 8397.0 sentences: 455.0 pages: flesch: 43.0 cache: ./cache/cord-004339-7nwpic3d.txt txt: ./txt/cord-004339-7nwpic3d.txt summary: Secondly, consent to have the discussion about the NAIROS trial with the investigator audio-recorded and their details passed onto • Any prior septal surgery • Systemic inflammatory disease or the use of any current oral steroid treatment within the past 2 weeks • Granulomatosis with polyangiitis • Nasendoscopic evidence of unrelated associated pathology, e.g. adenoid pad, septal perforation, chronic rhinosinusitis indicated by the presence of polyposis or pus • Any history of intranasal recreational drug use within the past 6 months • Breast-feeding, pregnancy or intended pregnancy for the duration of involvement in the trial • Bleeding diathesis • Therapeutic anticoagulation (warfarin/novel oral anti-coagulant (NOAC) therapy) • Clinically significant contraindication to general anaesthesia • Patients known to be immuno-compromised • Those in whom an external bony deformity substantially contributes to the nasal obstruction a member of the qualitative team for a telephone interview. abstract: BACKGROUND: Septoplasty (surgery to straighten a deviation in the nasal septum) is a frequently performed operation worldwide, with approximately 250,000 performed annually in the US and 22,000 in the UK. Most septoplasties aim to improve diurnal and nocturnal nasal obstruction. The evidence base for septoplasty clinical effectiveness is hitherto very limited. AIMS: To establish, and inform guidance for, the best management strategy for individuals with nasal obstruction associated with a deviated septum. METHODS/DESIGN: A multicentre, mixed-methods, open label, randomised controlled trial of septoplasty versus medical management for adults with a deviated septum and a reduced nasal airway. Eligible patients will have septal deflection visible at nasendoscopy and a nasal symptom score ≥ 30 on the NOSE questionnaire. Surgical treatment comprises septoplasty with or without reduction of the inferior nasal turbinate on the anatomically wider side of the nose. Medical management comprises a nasal saline spray followed by a fluorinated steroid spray daily for six months. The recruitment target is 378 patients, recruited from up to 17 sites across Scotland, England and Wales. Randomisation will be on a 1:1 basis, stratified by gender and severity (NOSE score). Participants will be followed up for 12 months post randomisation. The primary outcome measure is the total SNOT-22 score at 6 months. Clinical and economic outcomes will be modelled against baseline severity (NOSE scale) to inform clinical decision-making. The study includes a recruitment enhancement process, and an economic evaluation. DISCUSSION: The NAIROS trial will evaluate the clinical effectiveness and cost-effectiveness of septoplasty versus medical management for adults with a deviated septum and symptoms of nasal blockage. Identifying those individuals most likely to benefit from surgery should enable more efficient and effective clinical decision-making, and avoid unnecessary operations where there is low likelihood of patient benefit. TRIAL REGISTRATION: EudraCT: 2017–000893-12, ISRCTN: 16168569. Registered on 24 March 2017. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020359/ doi: 10.1186/s13063-020-4081-1 id: cord-258758-sz8chn5e author: Resch, Tim title: Atypical COVID -19 presentation in patient undergoing staged TAAA repair date: 2020-05-16 words: 1294.0 sentences: 77.0 pages: flesch: 56.0 cache: ./cache/cord-258758-sz8chn5e.txt txt: ./txt/cord-258758-sz8chn5e.txt summary: title: Atypical COVID -19 presentation in patient undergoing staged TAAA repair Patient was tested positive for Covid 19 virus and later during hospitalization developed more typical fever and respiratory symptoms that were managed medically. The 2 typical presenting symptoms in the majority of patients range from common upper respiratory 3 tract signs such as cough, sore throat and fever to more severe shortness of breath and severe 4 respiratory dysfunction. 9 We present a case of COVID 19 infection with atypical debut in a patient having undergone 10 staged, endovascular thoraco-abdominal repair 2 weeks previously. 14 The patient underwent stage 1, percutaneous thoracic endovascular repair (TEVAR) with 15 placement of a thoracic stent-graft from the left subclavian artery to 4 cm proximal to the celiac 16 artery origin (Fig 3) . Short-term outcome of spinal cord ischemia after endovascular repair of thoracoabdominal aortic 3 aneurysms Staged endovascular repair of thoracoabdominal 9 aortic aneurysms limits incidence and severity of spinal cord ischemia abstract: This report outlines a case of atypical presentation of Covid 19 viral infection. A 65-year old male was planned for a two staged repair of a Crawford type 3 thoracoabdominal aortic aneurysm. The first stage, TEVAR in descending aorta, was uneventful and patient was discharged on postoperative day 2. He was readmitted 10 days later, presenting with diarrhea, lower limb pain and weakness after 25 meters walking. The patient displayed no fever or upper respiratory tract signs or symptoms. Computer tomography and MR of the spinal cord were normal. Patient was tested positive for Covid 19 virus and later during hospitalization developed more typical fever and respiratory symptoms that were managed medically. url: https://www.sciencedirect.com/science/article/pii/S2468428720300642?v=s5 doi: 10.1016/j.jvscit.2020.05.001 id: cord-256051-87alqfkd author: Revzin, Margarita V. title: Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications date: 2020-10-01 words: 8850.0 sentences: 448.0 pages: flesch: 39.0 cache: ./cache/cord-256051-87alqfkd.txt txt: ./txt/cord-256051-87alqfkd.txt summary: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in coronavirus disease 2019 (COVID-19), which was declared an official pandemic by the World Health Organization on March 11, 2020. Although SARS-CoV-2 disease (or coronavirus disease 2019 ) primarily manifests as a lung infection, with symptoms ranging from those of a mild upper respiratory infection to severe pneumonia and acute respiratory distress syndrome (ARDS), other multisystemic manifestations of this disease and related complications are becoming more commonly recognized (3) . Thromboembolic complications, including pulmonary embolism (PE), peripheral venous and arterial thrombosis, and acute stroke (seen also in patients older than 50 years without risk factors) have all been reported (50-57). On the basis of the pattern and distribution of the opacities and the presence or absence of certain clinical signs (such as obesity), the authors developed a chest radiography severity scoring system that could be used as a prognostic factor of outcomes in young adult patients with COVID-19 (Fig 3) . abstract: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in coronavirus disease 2019 (COVID-19), which was declared an official pandemic by the World Health Organization on March 11, 2020. The infection has been reported in most countries around the world. As of August 2020, there have been over 21 million cases of COVID-19 reported worldwide, with over 800 000 COVID-19–associated deaths. It has become apparent that although COVID-19 predominantly affects the respiratory system, many other organ systems can also be involved. Imaging plays an essential role in the diagnosis of all manifestations of the disease, as well as its related complications, and proper utilization and interpretation of imaging examinations is crucial. With the growing global COVID-19 outbreak, a comprehensive understanding of the diagnostic imaging hallmarks, imaging features, multisystemic involvement, and evolution of imaging findings is essential for effective patient management and treatment. To date, only a few articles have been published that comprehensively describe the multisystemic imaging manifestations of COVID-19. The authors provide an inclusive system-by-system image-based review of this life-threatening and rapidly spreading infection. In part 1 of this article, the authors discuss general aspects of the disease, with an emphasis on virology, the pathophysiology of the virus, and clinical presentation of the disease. The key imaging features of the varied pathologic manifestations of this infection that involve the pulmonary and peripheral and central vascular systems are also described. Part 2 will focus on key imaging features of COVID-19 that involve the cardiac, neurologic, abdominal, dermatologic and ocular, and musculoskeletal systems, as well as pediatric and pregnancy-related manifestations of the virus. Vascular complications pertinent to each system will be also be discussed in part 2. Online supplemental material is available for this article. (©)RSNA, 2020 url: https://www.ncbi.nlm.nih.gov/pubmed/33001783/ doi: 10.1148/rg.2020200149 id: cord-266713-rghowch1 author: Reyes-Bueno, JA title: Case fatality of COVID-19 in patients with neurodegenerative dementia date: 2020-10-07 words: 2799.0 sentences: 181.0 pages: flesch: 52.0 cache: ./cache/cord-266713-rghowch1.txt txt: ./txt/cord-266713-rghowch1.txt summary: DISCUSSION Our results suggest that case fatality of COVID-19 is significantly higher among patients with primary degenerative dementia than in other patients with similar mean ages and comorbidities. S a m p l e c h a r a c t e r i s t i c s COVID-19 was diagnosed according to the classification of the Spanish Ministry of Health: confirmed cases (patients with positive RT-PCR results for SARS-CoV-2) and probable cases (patients with a severe acute respiratory infection requiring hospitalisation and with clinical and radiological characteristics compatible with COVID-19, in the absence of RT-PCR confirmation). 13 These results are similar to our own: we found a COVID-19-associated case fatality rate of 43.4% in patients with dementia; this was significantly higher than the rate in the control group. Heart diseases were more prevalent in the group of patients with primary degenerative dementia, and were associated with a statistically significant increase in the mortality rate. Our study suggests that the case fatality of COVID-19 is significantly higher in patients with primary degenerative dementia than among other patients with similar ages and comorbidities. abstract: INTRODUCTION The elderly population is the group most threatened by COVID-19, with the highest mortality rates. This study aims to analyse the case fatality of COVID-19 in a cohort of patients with degenerative dementia. METHODS We conducted a descriptive case-control study of a sample of patients diagnosed with primary neurodegenerative dementia. RESULTS Twenty-four of the 88 patients with COVID-19 included in the study died: 10/23 (43.4%) patients diagnosed with dementia and 14/65 (21.5%) controls; this difference was statistically significant. DISCUSSION Our results suggest that case fatality of COVID-19 is significantly higher among patients with primary degenerative dementia than in other patients with similar mean ages and comorbidities. url: https://api.elsevier.com/content/article/pii/S2173580820302157 doi: 10.1016/j.nrleng.2020.07.006 id: cord-267525-tg4uwent author: Rezaei, Shawheen J. title: Neuromyelitis optica practice and prescribing changes in the setting of Covid19: A survey of neurologists date: 2020-07-11 words: 2987.0 sentences: 149.0 pages: flesch: 47.0 cache: ./cache/cord-267525-tg4uwent.txt txt: ./txt/cord-267525-tg4uwent.txt summary: PURPOSE: This study reports and analyzes the findings from the responses of 192 neurologists in the United States and Canada to a new survey instrument distributed in April 2020 to assess NMO practice and prescribing changes during the Covid19 pandemic. The objective of this study is to document the prescribing and treatment patterns of neurologists with expertise in NMO patient care during the Covid19 pandemic. Neurologists also indicated several unmet needs for their NMO patients, including improved testing for Covid19, more information on the risks of NMO treatment in this context, and increased telemedicine access. Neurologists across the United States and Canada believe that Covid19 poses a higher-thanbaseline risk of disease among their NMO patients, in part due to the immunosuppressive nature of most NMO treatments currently available and necessarily in use. abstract: PURPOSE: This study reports and analyzes the findings from the responses of 192 neurologists in the United States and Canada to a new survey instrument distributed in April 2020 to assess NMO practice and prescribing changes during the Covid19 pandemic. PRINCIPAL RESULTS: 92% of responding neurologists considered their NMO patients to be at an elevated risk of acquiring Covid19. They also indicated sharp declines in visits, delays in treatment and related services, and several unmet needs deterring treatment. MAJOR CONCLUSIONS: There is a need for evidence-based, comprehensive guidelines for treating NMO patients amid healthcare crises moving forward. url: https://www.ncbi.nlm.nih.gov/pubmed/32682142/ doi: 10.1016/j.jneuroim.2020.577320 id: cord-281276-rffp6qe2 author: Rhazi, Karima El title: Ethical issues related to the hydroxychloroquine treatment prescription for Covid-19 date: 2020-06-17 words: 3414.0 sentences: 186.0 pages: flesch: 50.0 cache: ./cache/cord-281276-rffp6qe2.txt txt: ./txt/cord-281276-rffp6qe2.txt summary: The paper conclude that, since health authorities in some countries recommended this off-label use treatment, physicians are challenged by the requirement of veracity while providing care to their patients and the implications of such a requirement; they are facing the challenge of balancing this guideline and their own conviction. To date and after the fifth months into the novel coronavirus pandemic, no drugs have demonstrated safety and efficacy in randomized controlled trials for patients with COVID-19. This decision has raised many questions and some ethical issues related to the hydroxychloroquine treatment prescription might emerge during the Covid-19 patients'' management. Reluctancy regarding the use of this drug for the treatment of patients with Covid-19 is justified by the absence of a high level of scientific evidence namely randomized controlled clinical trials proving the superiority of this drug for this indication, as we discussed above. abstract: Abstract The 2019-20 coronavirus pandemic (COVID-19), has led to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, no drugs have demonstrated safety and efficacy in randomized controlled trials for patients with COVID-19. Although the association between Hydroxychloroquine and Azithromycin efficacy lack of solid evidence-base, several governments have adopted it for all virology confirmed Covid-19 cases even for those who are asymptomatic. In the following, we aim to discuss some of the ethical issues associated with the use of this treatment association. We mainly tried to discuss the following controversial questions: Is it ethical not to treat a patient while a treatment exists and is used for other indications than Covid-19 for which it’s not proven yet? If yes, is a randomized controlled trial to prove the hydroxychloroquine for the Covid-19 treatment, necessary, in the context of covid-19 pandemic? If No, is it the government’s right to decide the hydroxychloroquine treatment for all covid-19 patients? and what should be the physicians’ attitudes? Finally, what are the government, physicians, and patient’s rights and responsibilities? The paper conclude that, since health authorities in some countries recommended this off-label use treatment, physicians are challenged by the requirement of veracity while providing care to their patients and the implications of such a requirement; they are facing the challenge of balancing this guideline and their own conviction. Furthermore, the fundamental principles of beneficence and non-maleficence, and respect for persons should underlie any reflection process to address this dilemma. In addition, in a pandemic context, the limits between the government’s, practitioner’s and patient’s rights and obligations are not clear which could significantly endanger the universal ethical principles in clinical practice. It could also undermine any attempt to develop serious clinical trials to prove the considered off-label drug. url: https://www.ncbi.nlm.nih.gov/pubmed/32835062/ doi: 10.1016/j.jemep.2020.100547 id: cord-000457-e50a0suk author: Rhim, Jung-Woo title: Epidemiological and clinical characteristics of childhood pandemic 2009 H1N1 virus infection: an observational cohort study date: 2011-08-24 words: 3745.0 sentences: 182.0 pages: flesch: 48.0 cache: ./cache/cord-000457-e50a0suk.txt txt: ./txt/cord-000457-e50a0suk.txt summary: METHODS: We evaluated the epidemiologic characteristics of all the subjects infected with the 2009 H1N1 influenza A virus (2,971 patients, ≤ 15 years of age), and the clinical and laboratory findings of the inpatients (217 patients, 80 had pneumonia) between 1 September 2009 and 31 January 2010 in a single hospital throughout the epidemic. In addition, during the study period we observed a dramatic effect of early treatment with corticosteroids and oseltamivir for patients with severe pneumonia including rapidly progressive pneumonia [9, 10] . We retrospectively evaluated all patients with 2009 H1N1 virus infection during the pandemic (2,971 patients) for epidemiologic characteristics, and for clinical characteristics, we reviewed the medical records and chest radiographic findings of 217 children admitted to The Catholic University of Korea, Daejeon St Mary''s Hospital between 1 September 2009 and 31 January 2010. In pandemic 2009 H1N1 virus infections, children of all ages were evenly affected, and males were predominant in pneumonia patients. abstract: BACKGROUND: There was a pandemic influenza around the world in 2009 including South Korea since last pandemic occurred four decades ago. We aimed to evaluate the epidemiological and clinical characteristics of this infection in childhood. METHODS: We evaluated the epidemiologic characteristics of all the subjects infected with the 2009 H1N1 influenza A virus (2,971 patients, ≤ 15 years of age), and the clinical and laboratory findings of the inpatients (217 patients, 80 had pneumonia) between 1 September 2009 and 31 January 2010 in a single hospital throughout the epidemic. RESULTS: The age distribution of all the subjects was relatively even. Over 90% of cases occurred during a two-month period. Two hundred and five patients (94.5%) received oseltamivir within 48 h of fever onset, and 97% of inpatients defervesced within 48 h of medication. The group with pneumonia included more males than females, and had higher leukocytes counts with lower lymphocyte differentials than the group without pneumonia. The white blood cell count and lymphocyte differential were associated with the severity of pneumonia. Corticosteroid treatment for severe pneumonia patients was highly effective in preventing disease progression. CONCLUSION: Children of all ages affected with even rates of infection, but males were predominant in pneumonia patients. Pneumonia patients showed lymphopenia and its severity was associated with the severity of illness. Our results suggest that the mechanism of lung injury in 2009 H1N1 virus infection may be associated with the host immune response. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176209/ doi: 10.1186/1471-2334-11-225 id: cord-308445-3j2q83ll author: Rhim, Jung-Woo title: Pandemic 2009 H1N1 virus infection in children and adults: A cohort study at a single hospital throughout the epidemic date: 2012-03-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: In 2009, there was an influenza pandemic in South Korea. The aim of this study was to evaluate the epidemiological, clinical and laboratory characteristics of this infection in children and adults. METHODS: We evaluated the epidemiologic characteristics of patients infected with the 2009 H1N1 influenza A virus (4,463 patients, age range from 2 mo to 86 y), and the clinical and laboratory findings of 373 inpatients (80/217 children, ≤ 15 y, had pneumonia and 36/156 adults, > 16 y, had pneumonia) in a single hospital during the epidemic. RESULTS: The majority of infected patients (94%) were less than 40 y, and greater than 90% of cases occurred during a two-month period. The rates of admission and pneumonia were 8.4% (373/4,463) and 2.5% (116/4,463), respectively. The rates of admission and pneumonia, total duration of fever, the frequency of underlying diseases, and the values of C-reactive protein and erythrocyte sedimentation rate tended to increase as age increased; highest rates were found in the ≥ 65 y group. Pneumonia was founded more boys than girls in children, but more female than male in adults. The adult patients with pneumonia had higher leukocyte counts with lower lymphocyte differentials than the group without pneumonia, as shown in children group. CONCLUSION: Our results suggest that the immunologic reaction to viral insults may be associated with age, sex and underlying diseases, and that unknown herd immunity may affect populations. The patients with underlying diseases, especially in older patients may have immunologic insufficiency that is associated with immunologic consumption by the underlying diseases. url: https://www.ncbi.nlm.nih.gov/pubmed/22443897/ doi: 10.1186/1755-7682-5-13 id: cord-256634-gg8hptfg author: Rhodes, N. J. title: Multicenter point-prevalence evaluation of the utilization and safety of drug therapies for COVID-19 date: 2020-06-06 words: 4107.0 sentences: 260.0 pages: flesch: 50.0 cache: ./cache/cord-256634-gg8hptfg.txt txt: ./txt/cord-256634-gg8hptfg.txt summary: Conclusions: While we observed high rates of supportive care for patients with COVID-19, we also found that ADRs were common among patients receiving drug therapy including in clinical trials. The objective of this point-prevalence study was to characterize the drug therapies used in the management of COVID-19, including supportive care and combination therapies, in an attempt to identify safety signals among acutely ill hospitalized patients. Data elements collected included facility demographics, total number of hospital and ICU beds prior to the pandemic, U.S. Census region location, patient populations served, facility type (e.g., academic, community, inpatient rehabilitation), and active clinical trial site status. In addition to whether patients were receiving supportive care or drug therapies targeted at SARS-CoV-2, we collected basic patient demographic information and vital status (e.g., age, sex, comorbidities, oxygen requirement, and ICU status). Patients were significantly more likely to receive COVID-19 directed drug therapy if they were enrolled in a clinical trial (26.9% vs 3.2%; P <0.001). abstract: Background: There are currently no FDA-approved medications for the treatment of COVID-19. At the onset of the pandemic, off-label medication use was supported by limited or no clinical data. We sought to characterize experimental COVID-19 therapies and identify safety signals during this period. Methods: We conducted a non-interventional, multicenter, point prevalence study of patients hospitalized with suspected/confirmed COVID-19. Clinical and treatment characteristics within a 24-hour window were evaluated in a random sample of up to 30 patients per site. The primary objective was to describe COVID-19 targeted therapies. The secondary objective was to describe adverse drug reactions (ADRs). Results: A total of 352 patients from 15 US hospitals were included. Most patients were treated at academic medical centers (53.4%) or community hospitals (42.6%). Sixty-seven patients (19%) were receiving drug therapy in addition to supportive care. Drug therapies included hydroxychloroquine (69%), remdesivir (10%), and interleukin-6 inhibitors (9%). Five patients (7.5%) were receiving combination therapy. Patients with a history of asthma (14.9% vs. 7%, p=0.037) and those enrolled in clinical trials (26.9% vs. 3.2%, p<0.001) were more likely to receive therapy. Among those receiving COVID-19 therapy, eight patients (12%) experienced an ADR, and ADRs were more commonly recognized in patients enrolled in clinical trials (62.5% vs 22%, OR=5.9, p=0.028). Conclusions: While we observed high rates of supportive care for patients with COVID-19, we also found that ADRs were common among patients receiving drug therapy including in clinical trials. Comprehensive systems are needed to identify and mitigate ADRs associated with experimental COVID-19 therapies. url: https://www.ncbi.nlm.nih.gov/pubmed/32577687/ doi: 10.1101/2020.06.03.20121558 id: cord-281887-b511bjdy author: Ribeiro, Reitan title: Perioperative Cancer Care in the Context of Limited Resources during the COVID-19 Pandemic: Brazilian Society of Surgical Oncology Recommendations date: 2020-09-26 words: 4739.0 sentences: 234.0 pages: flesch: 45.0 cache: ./cache/cord-281887-b511bjdy.txt txt: ./txt/cord-281887-b511bjdy.txt summary: DISCUSSION: The rational use of resources to reduce the risk of surgical cancer patients being operated on during the incubation period of a corona virus infection is important in this context. CONCLUSIONS: We present a protocol, focused on the patients'' outcomes, for safe and rational use of resources to reduce the risk of surgical cancer patients being operated on during the virus incubation period, in the context of areas with limited resources. Our objective was to present the Brazilian Society of Surgical Oncology (BSSO) protocol for rational use of resources and for reducing the risk of surgical cancer patients being operated on during the coronavirus incubation period, in the context of areas with limited resources, and focused on patient outcomes. In light of all the previous considerations, Table 3 presents our suggested protocol for the rational use of resources to reduce the risk of surgical cancer patients from being operated on during the COVID-19 incubation period, in the context of areas with limited resources. abstract: BACKGROUND: As the COVID-19 pandemic moves from rich to poor nations, the healthcare systems of developing countries have to deal with this extra burden. As cancer care cannot stop and surgery is the main mechanism for cure and palliation, it is important to provide safe and rational access to cancer surgery during the COVID-19 pandemic. METHODS: From April 1st to May 1st, the committee of the Brazilian Society of Surgical Oncology (BSSO) was responsible for reviewing the literature and writing recommendations for perioperative cancer care in the context of limited resources during the pandemic. The recommendations were submitted to the BSSO board of directors. The orientations that were not consensual were removed and the suggestions were added to the text. From May 15 to 30th, the committee revised the recommendations, aligned them with the objectives of the work and standardize the text. DISCUSSION: The rational use of resources to reduce the risk of surgical cancer patients being operated on during the incubation period of a corona virus infection is important in this context. Prevalence of corona virus in the region, the need for surgery, surgical complexity, patient age and comorbidities, and availability of corona virus testing are central aspects in this matter and are discussed. CONCLUSIONS: We present a protocol, focused on the patients’ outcomes, for safe and rational use of resources to reduce the risk of surgical cancer patients being operated on during the virus incubation period, in the context of areas with limited resources. url: https://doi.org/10.1245/s10434-020-09098-x doi: 10.1245/s10434-020-09098-x id: cord-011793-hlktpla4 author: Rice, Todd W. title: In Defense of Evidence-based Medicine for the Treatment of COVID-19 Acute Respiratory Distress Syndrome date: 2020-07-17 words: 1828.0 sentences: 81.0 pages: flesch: 42.0 cache: ./cache/cord-011793-hlktpla4.txt txt: ./txt/cord-011793-hlktpla4.txt summary: Although the desire to try to treat these patients with already approved drugs is understandable, what is less understandable is the desire in medical publications and on social media to abandon the principles of evidence-based critical care that we have established over the last 3 decades (9), because "I have never seen patients with ARDS act like this." Large, well-designed, multicenter randomized trials have set the foundation of an evidence-based practice of how to produce the best outcomes for critically ill patients. Instead, improved outcomes are seen through understanding and implementing best practices derived via strong scientific evidence generated from well-designed randomized controlled trials into the routine care of critically ill patients. Maintaining other principles of good critical care, as demonstrated in large, multicenter randomized trials, will also improve outcomes in these critically ill patients with COVID-19, even if "COVID-19 is completely different from other intensive care unit syndromes." Conservative fluid management once out of shock and without renal failure increases time alive and free from ventilation (15) . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328187/ doi: 10.1513/annalsats.202004-325ip id: cord-024073-243addff author: Richards, Guy title: COVID-19 and the Rationale for Pharmacotherapy: A South African Perspective date: 2020-04-17 words: 3402.0 sentences: 188.0 pages: flesch: 49.0 cache: ./cache/cord-024073-243addff.txt txt: ./txt/cord-024073-243addff.txt summary: All of the patients had deteriorated despite routine therapies in the previous week, and the agent is now listed as a treatment option for severe or critical cases with elevated IL-6 in the National Health Commission of the People''s Republic of China COVID-19 Diagnosis and Treatment Guide.(35) A very recent case study has described the successful use of Tmab in a patient on maintenance therapy for multiple myeloma who had received bortezomib, thalidomide and dexamethasone therapy approximately 4 years previously and had been on thalidomide maintenance since then. A systematic review of observational studies of corticosteroids administered to patients with SARS-CoV-1 reported no survival benefit and possible harm and increased mortality and secondary infections were noted with severe influenza A; however, the evidence quality was low.(43) A subsequent study noted in the WHO guidelines found no effect on mortality. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187737/ doi: 10.18772/26180197.2020.v2nsia2 id: cord-017489-ftz9190a author: Richards, Guy A. title: Viruses in the Intensive Care Unit (ICU) date: 2005 words: 5792.0 sentences: 330.0 pages: flesch: 44.0 cache: ./cache/cord-017489-ftz9190a.txt txt: ./txt/cord-017489-ftz9190a.txt summary: Pneumonia is the most common complication, which occurs in high-risk patients including those with comorbid illness such as cardiovascular or pulmonary disease, diabetes, renal failure, immunosuppression, the elderly, or residents of nursing homes. A study performed in our ICU indicates that corticosteroids may dramatically alter the course of the most severe disease and should be considered in addition to antiviral therapy along with appropriate supportive care in any previously well patient with life threatening varicella pneumonia (42). Patients with HIV or AIDS (acquired immunodeficiency syndrome) who are hospitalized with chickenpox appear to be at high risk for developing varicella pneumonia, which manifests in a similar clinical fashion to that in immunocompetent individuals. In another study of 68 adult patients admitted with measles diagnosed on clinical and serological grounds, 9 required intensive care, six mechanical ventilation for approximately 15 days, and two deaths occurred. abstract: Whereas viruses are not usually considered to be important causes of ICU admission this review has demonstrated this perception to be incorrect. Viruses and their manifestations differ from continent to continent and hemisphere to hemisphere and it is essential that the intensivist be familiar with diagnosis and management of these ubiquitous organisms. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122063/ doi: 10.1007/0-387-23380-6_3 id: cord-268252-6g0vbd08 author: Richards, Wayne title: Being a dentist in the pandemic date: 2020-06-26 words: 524.0 sentences: 60.0 pages: flesch: 54.0 cache: ./cache/cord-268252-6g0vbd08.txt txt: ./txt/cord-268252-6g0vbd08.txt summary: The authors provide information on the COVID-19 pandemic in order to inform front-line dentists. The paper is as essay on the available information relating to: Background to the pandemic • Coronaviruses in general • Pathogenesis • COVID-19 • Clinical manifestations • Patient characteristics • Diagnosis • Protocol for managing the disease in the clinical setting • Transmission dynamics • Transmission dynamics in dentistry practice • Infection control • Mouth rinses • Rubber dam isolation • Anti-retraction handpiece • Appropriate disinfectants • Management of medical waste. The authors apply available international guidelines to provide a protocol for managing possible exposure to patients or those suspected of having a 2019-nCoV infection. Practice point • Cross infection protocols will prove essential to protect dentists, patients and society at large in the current pandemic. In dentistry face to face contact with patients means dental personnel are exposed to respiratory tract secretions, blood, saliva and other contaminated body fluids. abstract: Data sources The authors provide no detail as to how the review was undertaken. Therefore the paper does not provide any methodological processes for data extraction. The paper describes the assimilation of available information regarding 2019-nCoV at the time of writing. The authors provide information on the COVID-19 pandemic in order to inform front-line dentists. The paper is as essay on the available information relating to: Background to the pandemic • Coronaviruses in general • Pathogenesis • COVID-19 • Clinical manifestations • Patient characteristics • Diagnosis • Protocol for managing the disease in the clinical setting • Transmission dynamics • Transmission dynamics in dentistry practice • Infection control • Mouth rinses • Rubber dam isolation • Anti-retraction handpiece • Appropriate disinfectants • Management of medical waste. Conclusions Face-to-face communication and consistent exposure to body fluids such as blood and saliva predispose dental care workers to risk of infection and there is high risk of cross-infection. The authors apply available international guidelines to provide a protocol for managing possible exposure to patients or those suspected of having a 2019-nCoV infection. Dentists play a significant role in disrupting the transmission trail of the virus by simply postponing non-emergency care for all patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32591660/ doi: 10.1038/s41432-020-0095-5 id: cord-331270-12zx0o2p author: Rico, Timóteo Matthies title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial date: 2020-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Cancer patients are often not sufficiently oriented to manage side effects at home. Sending text messages with self-care guidelines aimed managing side effects is the main objective of this randomized controlled trial. Patients who started outpatient chemotherapy treatment between March and December 2017 at a hospital in southern Brazil were invited to participate in this study and were allocated to the intervention or control group (ratio 1: 1). Each patient in the intervention group received a daily SMS (short message service) with some guidance on management or prevention of side effects. All text messages were sent to the intervention group patients in an automated and tailored way by our app called cHEmotHErApp. Side effects experienced by patients were verified using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30). Results showed intervention group patients experienced fewer side effects compared to the control group in cycle 1 (p < 0.05), in general. In addition, intervention group experienced less nausea in relation to the control group, in the cycle 1 and cycle 2 (p < 0.05). This study indicate text messaging may be a tool for supporting side effect management in patients receiving chemotherapy. This study was enrolled in ClinicalTrials.gov with the identification number NCT03087422. This research was performed in accordance with the Declaration of Helsinki. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10916-020-01663-x) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s10916-020-01663-x doi: 10.1007/s10916-020-01663-x id: cord-034690-x8lkngra author: Ridge, Carole A title: Dual-Energy CT Pulmonary Angiography (DECTPA) Quantifies Vasculopathy in Severe COVID-19 Pneumonia date: 2020-10-29 words: 3213.0 sentences: 178.0 pages: flesch: 46.0 cache: ./cache/cord-034690-x8lkngra.txt txt: ./txt/cord-034690-x8lkngra.txt summary: Qualitative and quantitative analysis of perfused blood volume (PBV) maps recorded: i) perfusion defect ''pattern'' (wedge-shaped, mottled or amorphous), ii) presence of PT and CT obstruction index (CTOI) and iii) PBV relative to pulmonary artery enhancement (PBV/PAenh); PBV/PAenh was also compared with seven healthy volunteers and correlated with D-Dimer and CTOI. Accordingly, in the present study we aimed to evaluate the relationships between a quantitative measure of perfusion on DECTPA (relative perfused blood volume, PBV/PAenh) (22) , and i) disease duration, ii) right ventricular dysfunction on echocardiography iii) Ddimer levels and (iv) obstruction score (23) in patients with severe COVID-19 pneumonia. This early data demonstrated perfusion defects on perfused blood volume (PBV) maps, when available, as well as the presence of vascular dilatation on conventional CT, hypercoagulability and an increased dead space in 39 patients suggesting that pulmonary angiopathy was accountable for hypoxia observed in patients requiring mechanical ventilation for severe COVID-19 pneumonia. abstract: BACKGROUND: The role of dual energy computed tomographic pulmonary angiography (DECTPA) in revealing vasculopathy in coronavirus disease 2019 (COVID-19) has not been fully explored. PURPOSE: To evaluate the relationship between DECTPA and disease duration, right ventricular dysfunction (RVD), lung compliance, D-dimer and obstruction index in COVID-19 pneumonia. MATERIALS AND METHODS: This institutional review board approved this retrospective study, and waived the informed consent requirement. Between March-May 2020, 27 consecutive ventilated patients with severe COVID-19 pneumonia underwent DECTPA to diagnose pulmonary thrombus (PT); 11 underwent surveillance DECTPA 14 ±11.6 days later. Qualitative and quantitative analysis of perfused blood volume (PBV) maps recorded: i) perfusion defect ‘pattern’ (wedge-shaped, mottled or amorphous), ii) presence of PT and CT obstruction index (CTOI) and iii) PBV relative to pulmonary artery enhancement (PBV/PAenh); PBV/PAenh was also compared with seven healthy volunteers and correlated with D-Dimer and CTOI. RESULTS: Amorphous (n=21), mottled (n=4), and wedge-shaped (n=2) perfusion defects were observed (M=20; mean age=56 ±8.7 years). Mean extent of perfusion defects=36.1%±17.2. Acute PT was present in 11/27(40.7%) patients. Only wedge-shaped defects corresponded with PT (2/27, 7.4%). Mean CTOI was 2.6±5.4 out of 40. PBV/PAenh (18.2 ±4.2%) was lower than in healthy volunteers (27 ±13.9%, p = 0.002). PBV/PAenh correlated with disease duration (β = 0.13, p = 0.04), and inversely correlated with RVD (β = -7.2, p = 0.001), persisting after controlling for confounders. There were no linkages between PBV/PAenh and D-dimer or CTOI. CONCLUSION: Perfusion defects and decreased PBV/PAenh are prevalent in severe COVID-19 pneumonia. PBV/PAenh correlates with disease duration and inversely correlates with RVD. PBV/PAenh may be an important marker of vasculopathy in severe COVID-19 pneumonia even in the absence of arterial thrombus. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605077/ doi: 10.1148/ryct.2020200428 id: cord-291697-wpnq9wc0 author: Riechelmann, Rachel P title: Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group date: 2020-05-22 words: 5855.0 sentences: 390.0 pages: flesch: 44.0 cache: ./cache/cord-291697-wpnq9wc0.txt txt: ./txt/cord-291697-wpnq9wc0.txt summary: RESULTS: Overall and tumour-specific recommendations were made by stage (including surgical, locoregional, radiotherapy, systemic treatments and follow-up strategies) for the most common gastrointestinal malignancies: esophagus, gastric, pancreas, bile duct, hepatocellular, colorectal, anal cancer and neuroendocrine tumours. All the recommendations proposed in this manuscript, besides being evidencebased, aimed at the following objectives: (1) to prioritise curative-intent cancer treatments during the pandemic; (2) to support the treatment of aggressive tumours when effective therapies are available; (3) to decrease the number of or delay oncological non-priority surgeries; (4) to decrease hospital visits (e.g., substitute intravenous for similarly effective oral drugs; propose when and to whom treatments delays/ interruption/watchful waiting can be offered); (5) to minimise anticancer therapy-related immunosuppression in specific high-risk groups (here defined as: elderly, comorbid illnesses [especially diabetes, cardiovascular and/or pulmonary concurrent diseases], fragility, ECOG 2 or higher). abstract: PURPOSE: As of 2020, the world is facing the great challenge of the COVID-19 (Coronavirus disease 2019) pandemic, caused by the SARS-CoV-2 virus. While the overall mortality is low, the virus is highly virulent and may infect millions of people worldwide. This will consequently burden health systems, particularly by those individuals considered to be at high risk of severe complications from COVID-19. Such risk factors include advanced age, cardiovascular and pulmonary diseases, diabetes and cancer. However, few data on the outcomes of cancer patients infected by SARS CoV-2 exist. Therefore, there is a lack of guidance on how to manage cancer patients during the pandemic. We sought to propose specific recommendations about the management of patients with gastrointestinal malignancies. METHODS: The Brazilian Gastrointestinal Tumours Group board of directors and members sought up-to-date scientific literature on each tumour type and discussed all recommendations by virtual meetings to provide evidence-based—and sometimes, expert opinion—recommendation statements. Our objectives were to recommend evidence-based approaches to both treat and minimise the risk of COVID-19 for cancer patients, and simultaneously propose how to decrease the use of hospital resources at a time these resources need to be available to treat COVID-19 patients. RESULTS: Overall and tumour-specific recommendations were made by stage (including surgical, locoregional, radiotherapy, systemic treatments and follow-up strategies) for the most common gastrointestinal malignancies: esophagus, gastric, pancreas, bile duct, hepatocellular, colorectal, anal cancer and neuroendocrine tumours. CONCLUSIONS: Our recommendations emphasise the importance of treating cancer patients, using the best evidence available, while simultaneously taking into consideration the world-wide health resource hyperutilisation to treat non-cancer COVID-19 patients. url: https://doi.org/10.3332/ecancer.2020.1048 doi: 10.3332/ecancer.2020.1048 id: cord-252539-kx8ew3ap author: Riera, Jordi title: Extracorporeal Membrane Oxygenation Retrieval in Coronavirus Disease 2019: A Case-Series of 19 Patients Supported at a High-Volume Extracorporeal Membrane Oxygenation Center date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To evaluate the performance of the extracorporeal membrane oxygenation retrieval team at a high-volume extracorporeal membrane oxygenation center during the coronavirus disease 2019 pandemic. DESIGN: Observational study including all adult patients with confirmed infection due to severe acute respiratory syndrome coronavirus-2 cannulated at other centers and transported on extracorporeal membrane oxygenation to the ICU of the Vall d’Hebron University Hospital between 15 March and 10 June 2020. SETTING: The ICU (capacity expanded to 200 during the pandemic) of the Vall d’Hebron University Hospital (a 1,100-bed public university hospital in Barcelona), the referral center for extracorporeal respiratory support in Catalonia (7.5 million inhabitants). PATIENTS: Extracorporeal membrane oxygenation was considered if the Pao(2)/Fio(2) ratio less than 80 mm Hg (refractory to prone position) and/or Paco(2) greater than 80 mm Hg and pH less than 7.25 for more than 6 hours, and no contraindications for extracorporeal support were present. INTERVENTIONS: Venovenous extracorporeal membrane oxygenation was initiated in the primary center. Then, patients were transferred to the ICU of the Vall d’Hebron University Hospital where they received support until respiratory improvement. After decannulation, patients were discharged for rehabilitation at the primary center. MEASUREMENTS AND MAIN RESULTS: Nineteen patients with severe acute respiratory syndrome coronavirus-2 infection and with a mean Pao(2)/Fio(2) ratio of 71 mm Hg (57–118 mm Hg) despite prone positioning and a mean Paco(2) of 70 mm Hg (47–110 mm Hg) were transferred to our center from their primary hospital after cannulation and received venovenous extracorporeal membrane oxygenation support. Prior to cannulation, six patients (31.5%) presented vascular thrombosis, and nine (47.4%) were already receiving anticoagulant therapy. Eighteen transfers were carried out with no significant complications. While on extracorporeal membrane oxygenation, thrombotic events were recorded in nine patients (47.4%) and hemorrhagic events in 13 (68.4%). Thirteen patients (68.4%) were successfully weaned, and 12 (63.1%) were discharged home. CONCLUSIONS: Extracorporeal membrane oxygenation retrieval can rescue young, previously healthy patients with severe coronavirus disease 2019 in whom all the conventional respiratory measures have failed. Thrombotic and hemorrhagic complications are frequent in this cohort. url: https://doi.org/10.1097/cce.0000000000000228 doi: 10.1097/cce.0000000000000228 id: cord-298894-t5hyfum3 author: Rifino, Nicola title: Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy date: 2020-10-07 words: 4682.0 sentences: 247.0 pages: flesch: 44.0 cache: ./cache/cord-298894-t5hyfum3.txt txt: ./txt/cord-298894-t5hyfum3.txt summary: Neurological manifestations were classified as: (a) cerebrovascular disease [53 pts (38.7%)] including 37 ischemic and 11 haemorrhagic strokes, 4 transient ischemic attacks, 1 cerebral venous thrombosis; (b) peripheral nervous system diseases [31 (22.6%)] including 17 Guillain–Barrè syndromes; (c) altered mental status [49 (35.8%)] including one necrotizing encephalitis and 2 cases with RT-PCR detection of SARS-Cov-2 RNA in CSF; (d) miscellaneous disorders, among whom 2 patients with myelopathy associated with Ab anti-SARS-CoV-2 in CSF. COVID-19 diagnosis was confirmed: (1) by real-time reverse-transcriptase polymerase-chain-reaction (RT-PCR) on nasopharyngeal specimens [13] ; or (2) by RT-PCR on bronchoalveolar lavage (BAL) obtained by bronchoscopy in case of high clinical suspicion of SARS-CoV-2 infection and negative test results on at least two nasopharyngeal swabs performed at least 24 h apart; or (3) in the presence of characteristic radiological interstitial pneumonia associated with typical symptoms (fever, dry cough, dyspnea), even with negative RT-PCR, with no other possible aetiologic explanation. abstract: OBJECTIVES: Evidences from either small series or spontaneous reporting are accumulating that SARS-CoV-2 involves the Nervous Systems. The aim of this study is to provide an extensive overview on the major neurological complications in a large cohort of COVID-19 patients. METHODS: Retrospective, observational analysis on all COVID-19 patients admitted from February 23rd to April 30th, 2020 to ASST Papa Giovanni XXIII, Bergamo, Italy for whom a neurological consultation/neurophysiological assessment/neuroradiologic investigation was requested. Each identified neurologic complication was then classified into main neurologic categories. RESULTS: Of 1760 COVID-19 patients, 137 presented neurologic manifestations that manifested after COVID-19 symptoms in 98 pts and was the presenting symptom in 39. Neurological manifestations were classified as: (a) cerebrovascular disease [53 pts (38.7%)] including 37 ischemic and 11 haemorrhagic strokes, 4 transient ischemic attacks, 1 cerebral venous thrombosis; (b) peripheral nervous system diseases [31 (22.6%)] including 17 Guillain–Barrè syndromes; (c) altered mental status [49 (35.8%)] including one necrotizing encephalitis and 2 cases with RT-PCR detection of SARS-Cov-2 RNA in CSF; (d) miscellaneous disorders, among whom 2 patients with myelopathy associated with Ab anti-SARS-CoV-2 in CSF. Patients with peripheral nervous system involvement had more frequently severe ARDS compared to patients with cerebrovascular disease (87.1% vs 42%; difference = 45.1% 95% CI 42.0–48.2; χ(2)= 14.306; p < 0.0002) and with altered mental status (87.1% vs 55.6%; difference = 31.5% 95% CI 27.5–37.5%; χ(2)= 7.055; p < 0.01). CONCLUSION: This study confirms that involvement of nervous system is common in SARS-CoV-2 infection and offers clinicians useful information for prevention and prompt identification in order to set the adequate therapeutic strategies. url: https://doi.org/10.1007/s00415-020-10251-5 doi: 10.1007/s00415-020-10251-5 id: cord-342451-yfy5jcw6 author: Rigamonti, Andrea title: Cerebral venous thrombosis associated with coronavirus infection: an underestimated entity? date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s10072-020-04539-7 doi: 10.1007/s10072-020-04539-7 id: cord-257035-ob1xncbs author: Rigatelli, Gianluca title: Intubation and Ventilation amid COVID-19: Comment date: 2020-05-11 words: 730.0 sentences: 47.0 pages: flesch: 43.0 cache: ./cache/cord-257035-ob1xncbs.txt txt: ./txt/cord-257035-ob1xncbs.txt summary: The recent published literature regarding the occurrence of acute respiratory syndrome (ARDS) in COVID-19 patients have mainly focused attention on the role of computed tomography in evaluating the radiological manifestations and temporal progression of the disease, 2 while few data have been presented regarding the use of lung ultrasonography, 3 especially in the evaluation of the disease course. have recently highlighted that lung recruitability can be effectively assessed bedside in COVID-19 patients with ARDS. The authors did not report data regarding the use of lung ultrasonography for the cited purposes. Since treatment of severe ARDS from COVID-19 is an ongoing challenge, it is important to learn from the patients who have been treated to gain an understanding of the disease''s epidemiology, its biologic mechanisms, and the effects of new pharmacologic interventions. Lung ultrasound can be used to predict the potential of prone positioning and assess prognosis in patients with acute respiratory distress syndrome abstract: nan url: https://doi.org/10.1097/aln.0000000000003374 doi: 10.1097/aln.0000000000003374 id: cord-346539-kxnrf5g5 author: Riggioni, Carmen title: A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2 date: 2020-06-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID‐19). This disease, caused by the severe acute respiratory syndrome‐related coronavirus 2 (SARS‐CoV‐2), has developed into a pandemic. To date it has resulted in ~6.5 million confirmed cases and caused almost 400,000 related deaths worldwide. Unequivocally, the COVID‐19 pandemic is the gravest health and socio‐economic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence‐based medical advice on SARS‐CoV‐2 and COVID‐19. Although the majority of the patients show a very mild, self‐limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID‐19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a “cytokine storm” leading to acute respiratory distress syndrome, endothelitis, thrombo‐embolic complications and multiorgan failure. The epidemiologic features of COVID‐19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID‐19‐related topics should be based on more coordinated high‐quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS‐CoV‐2, COVID‐19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. Over 140 questions were answered by experts in the field providing a comprehensive and practical overview of COVID‐19 and allergic disease. url: https://www.ncbi.nlm.nih.gov/pubmed/32535955/ doi: 10.1111/all.14449 id: cord-017040-4zajnrsf author: Rihana, Nancy title: Skin Infections date: 2019-08-11 words: 6486.0 sentences: 408.0 pages: flesch: 36.0 cache: ./cache/cord-017040-4zajnrsf.txt txt: ./txt/cord-017040-4zajnrsf.txt summary: Pseudomonas aeruginosa, usually a nosocomial pathogen has emerged as a common cause of infection in immunocompromised patients; most often in neutropenic leukemics during chemotherapy. The dermatologic manifestations of Pseudomonas sepsis include ecthyma gangrenosum, hemorrhagic bullae, necrotizing/gangrenous or bullous cellulitis, painful vesicular lesions, and small papules on the trunk resembling rose spots of typhoid fever, grouped petechiae, erysipelas-like lesions with hyperesthesia, erythematous or violaceous subcutaneous painful nodules, and necrotizing or malignant external otitis [3] . In the immunocompromised, the typical history of previous trauma or surgery is absent, thus cutaneous Mycobacteria infection are most probably the result of hematogenic dissemination, resulting in multiple skin lesions. Although aspergillus is one of the most common etiologies of invasive fungal infections in patients with underlying malignancies, dermatologic manifestations occurs in less than 5% of cases [41, 42] . Cutaneous lesions typically present in cases of disseminated disease and often mimic other dermatologic infections due its'' ability to manifest with many skin findings including papules, plaques, nodules, ulcers or pustules. abstract: Cutaneous infections are common in immunocompromised patients. Neutropenia predisposes patients to fungal, bacterial and viral infections. Antibacterial antifungal and antiviral prophylaxis have caused a significant reduction in some of these infections. There are two main types of cutaneous infections : primary cutaneous infections and cutaneous manifestations of a disseminated infection. In the latter, skin lesions may be the window to disseminated bloodstream infection and the first and only evidence of a disseminated life threatening infection. The diagnosis may be at your fingertips; therefore a thorough skin exam is the clue. However, it’s also important to know the characteristic lesions associated with different infections. It will help expedite diagnosis so appropriate treatment is initiated promptly in neutropenic patients, which can be lifesaving. In a retrospective study of 43 neutropenic febrile patients with cutaneous lesions, fungal infections were the most frequent, and nodular lesions on the lower extremities were the most prevalent (Naorungroj and Aiempanakit, J Am Acad Dermatol 74:AB166, 2016). Skin biopsy for pathological study and culture remains the gold standard and should be obtained early to confirm the suspected diagnosis. In these immunocompromised patients the inflammatory response is altered by either the primary disease or its treatment. Therefore, routine pathogens may present in an atypical fashion, with diminished or absent induration, erythema, or pustulation in response to bacterial resulting cutaneous infection without typical cellulitis (Urabe, Clin Infect Dis 39:S53–S55, 2004). Skin lesions are evaluated not only by morphology, but also in the context of the clinical setting and biopsy result. The skin biopsy is inexpensive, relatively noninvasive and without contraindication, and may avoid the need for more invasive procedures such an open lung biopsy (Grossman, et al., Cutaneous manifestations of infection in the immunocompromised host. Springer Science+Business Media, LLC, New York, 2012). In addition to antimicrobial therapy, surgery should not be postponed in the face of progressive skin and soft tissue infection in this population (Brzozowski and Ross, J Hand Surg Br 22:679–680, 1997). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121505/ doi: 10.1007/978-3-030-21859-1_5 id: cord-010487-wncgecld author: Rinella, Mary E. title: STELLAR 3 and STELLAR 4: Lessons From the Fall of Icarus date: 2020-04-30 words: 1408.0 sentences: 72.0 pages: flesch: 51.0 cache: ./cache/cord-010487-wncgecld.txt txt: ./txt/cord-010487-wncgecld.txt summary: Here, the ASK-1 inhibitor, selonsertib, was compared to placebo in ~1700 patients with NASH and bridging fibrosis (F3, STELLAR-3) or compensated cirrhosis (F4, STELLAR-4). In the absence of a placebo controlled phase 2b study, STELLAR 3 and 4 were substantially informed by a phase 2 study, [5] in which NASH patients with F2/F3 were recruited in a multicenter trial and randomized in a 2:2:1:1:1 ratio to receive 24 weeks of treatment with 6 mg or 18 mg of selonsertib alone; 6 mg or 18 mg of selonsertib with 125 mg of simtuzumab; or 125 mg of simtuzumab alone. The STELLAR studies did not meet their primary outcomes, and selonsertib was ineffective in reversing fibrosis in NASH patients with stage F3 and F4 fibrosis -those most in need of treatment. A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191297/ doi: 10.1016/j.jhep.2020.04.034 id: cord-279480-nqp1pc9v author: Ring, Laurence E. title: What Obstetricians should know about Obstetric Anesthesia during the COVID-19 pandemic date: 2020-08-26 words: 2783.0 sentences: 144.0 pages: flesch: 39.0 cache: ./cache/cord-279480-nqp1pc9v.txt txt: ./txt/cord-279480-nqp1pc9v.txt summary: Suggested modifications include an added emphasis on avoiding general anesthesia, a strong encouragement to infected individuals to opt for early neuraxial analgesia, and the prevention of emergent cesarean delivery, whenever possible. Compared to standard care in noninfected patients, the anesthesiologist may be more likely to replace a questionably functional epidural catheter in COVID-19 infected patients, in hopes to avoid urgent situations that may increase the odds for patient adverse outcomes (e.g. accidental dural puncture during a replacement of epidural catheter, or general anesthesia if urgent cesarean delivery) or avoidable exposures for healthcare providers (rushed replacement of neuraxial analgesia/anesthesia or general anesthesia in the operating room). If there does need to be a cesarean delivery on a patient who does not have an epidural catheter and is COVID-19 positive, the anesthesia team will need to weigh the risk of general anesthesia, including the risk staff exposure, to the possible risk of delay due to placement of a neuraxial block (typically a single shot spinal). abstract: The COVID-19 pandemic has prompted obstetric anesthesiologists to reconsider the ways in which basic anesthesia care is provided on the Labor and Delivery Unit. Suggested modifications include an added emphasis on avoiding general anesthesia, a strong encouragement to infected individuals to opt for early neuraxial analgesia, and the prevention of emergent cesarean delivery, whenever possible. Through team efforts, adopting these measures can have real effects on reducing the transmission of the viral illness and maintaining patient and caregiver safety in the labor room. url: https://doi.org/10.1016/j.semperi.2020.151277 doi: 10.1016/j.semperi.2020.151277 id: cord-317918-pl625ela author: Ripa, Marco title: Secondary Infections in Patients Hospitalized with COVID-19: Incidence and Predictive Factors date: 2020-10-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: Aim of our study was to describe the incidence and predictive factors of secondary infections in patients with COVID-19. METHODS: Cohort study on patients hospitalized with COVID-19 at IRCCS San Raffaele Hospital between February 25(th) and April 6th, 2020 (NCT04318366). We considered secondary bloodstream (BSIs) or possible lower respiratory tract infections (pLRTIs) occurred after 48 hours since hospital admission until death or discharge. We calculated multivariable Fine-Gray models, to assess factors associated with risk of secondary infections. RESULTS: Among 731 patients, a secondary infection was diagnosed in 68 patients (9.3%): 58/731 patients (7.9%) had at least one BSI and 22/731 patients (3.0%) at least one pLRTI. Overall 28-day cumulative incidence was 16.4% (95% CI 12.4% - 21.0%). The majority of BSIs was due to gram-positive pathogens (76/106 isolates, 71.7%), specifically coagulase-negative staphylococci (53/76, 69.7%), while among gram-negatives (23/106, 21.7%) Acinetobacter baumanii (7/23, 30.4%) and Escherichia coli (5/23, 21.7%) predominated. pLRTIs were mainly caused by gram-negative pathogens (14/26, 53.8%). Eleven patients were diagnosed with putative invasive aspergillosis. At multivariable analysis, factors associated with secondary infections were low baseline lymphocyte count (<0.7 vs >0.7 per 10(9)/L: subdistribution hazard ratios (sdHRs) 1.93 [95% CI 1.11-3.35]), baseline PaO(2)/FiO(2) (per 100-points lower: sdHRs 1.56 [95% CI 1.21-2.04]), and intensive-care unit (ICU) admission in the first 48 hours (sdHR 2.51 [95% CI 1.04-6.05]). CONCLUSIONS: Patients hospitalized with COVID-19 had a high incidence of secondary infections. At multivariable analysis, early need for ICU, respiratory failure, and severe lymphopenia, were identified as risk factors for secondary infections. url: https://www.sciencedirect.com/science/article/pii/S1198743X20306522?v=s5 doi: 10.1016/j.cmi.2020.10.021 id: cord-325649-zzhsrytw author: Rispoli, Rossella title: Spine surgery in Italy in the COVID-19 era: Proposal for assessing and responding to the regional state of emergency date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract In December 2019, coronavirus disease 2019 (COVID-19) was discovered in Wuhan, Hubei province, from where it spread rapidly across the globe. COVID-19 characteristics – elevated infectivity, rapid spread, and general population susceptibility – pose a great challenge to hospitals. Infectious disease, pulmonology, and intensive care units have been strengthened and expanded. All other specialties have been compelled to suspend or reduce clinical and elective surgical activities. The profound effects on spine surgery call for systematic approaches to optimizing the diagnosis and treatment of spinal diseases. Here, based on the experience of one Italian region, we draw an archetype for assessing the current and predicted level of stress in the health care system, with the aim of enabling hospitals to make better decisions during the pandemic. Further, we provide a framework that may help guide strategies for adapting surgical spine care to the conditions of epidemic surge. url: https://www.ncbi.nlm.nih.gov/pubmed/32777401/ doi: 10.1016/j.wneu.2020.08.001 id: cord-299222-vmofcrim author: Rivas‐Pollmar, María Isabel title: Thromboprophylaxis in a patient with COVID‐19 and severe hemophilia A on emicizumab prophylaxis date: 2020-06-11 words: 1571.0 sentences: 78.0 pages: flesch: 37.0 cache: ./cache/cord-299222-vmofcrim.txt txt: ./txt/cord-299222-vmofcrim.txt summary: All rights reserved Due to uncertainty about the risk of an increased prothrombotic state in CAC in association with emicizumab prophylaxis, thromboprophylaxis with low molecular weight heparin (LMWH), enoxaparin 40 mg once daily, was started. Bearing in mind the low risk of thrombosis with emicizumab in SHA without inhibitors, but because some of the mechanisms associated with the risk of thrombosis described above could be risk factors for the development of CAC, and in the absence of literature or guidelines for the management of such patients, our consensus clinical decision was to administer prophylactic doses of LMWH and to monitor laboratory parameters to follow up the disease and cytokine release storm. But we proposed the use of prophylactic dose of LMWH in SHA on emicizumab treatment at diagnosis, based on the low rate of bleeding complications associated with its abstract: COVID‐19 can be associated with coagulopathy (CAC, COVID‐19‐associated coagulopathy) with a high prothrombotic risk based on an intense inflammatory response to viral infection leading to immunothrombosis through different procoagulant pathways[1]. Emerging evidence suggests that the use of heparin in these patients could be associated with lower mortality[2]. url: https://doi.org/10.1111/jth.14954 doi: 10.1111/jth.14954 id: cord-263061-ocplcdiv author: Rivetti, Luigi title: Management of Pacemaker Implantation during COVID-19 Infection date: 2020-10-24 words: 1362.0 sentences: 65.0 pages: flesch: 46.0 cache: ./cache/cord-263061-ocplcdiv.txt txt: ./txt/cord-263061-ocplcdiv.txt summary: This is the first case of complete atrioventricular block in a symptomatic patient affected by the COVID-19 infection treated with early pacemaker implantation to minimize the risk of virus contagion. Recently, the European Society of Cardiology (ESC) Guidance [2] and Italian position paper [3] about the treatment of cardiovascular (CV) disease in COVID 19 infection patients have been published; however, the suggested management of atrioventricular (AV) conduction disorder patients is not matching between the two proposed guidelines. Hence, the ESC recommendation [2] suggested a medical drug approach with isoprenaline and atropine and the implantation of temporary PM (tPM), leading the potential pPM after recovery from the COVID-19 infection. Conversely, the Italian position paper [3] recommends avoiding in any cases the tPM for risk infection, thus preferring early pPM implantation. abstract: The management of device implantation during the COVID-19 infection has not well defined yet. This is the first case of complete atrioventricular block in a symptomatic patient affected by the COVID-19 infection treated with early pacemaker implantation to minimize the risk of virus contagion. url: https://doi.org/10.1155/2020/8833660 doi: 10.1155/2020/8833660 id: cord-271180-cnrs0zpg author: Rizvi, Saniya title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date: 2020-09-18 words: 3896.0 sentences: 220.0 pages: flesch: 49.0 cache: ./cache/cord-271180-cnrs0zpg.txt txt: ./txt/cord-271180-cnrs0zpg.txt summary: CytosorbentsⓇ cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. The following is a case report on a patient encounter and management course through the course of illness in which the Cytosorbents Ⓡ filter was used for his presentation of COVID-19 with severe ARDS, worsening renal dysfunction and evidence of evolving cytokine storm. Chest x-ray hospital day 16, 5 days after the initiation of cytokine filter when the patient developed worsening hypoxia and increased oxygen requirements as indicated in Table 2 below. abstract: COVID-19 is a pandemic that has affected not only the United States, but the entire world. The impact it has had has overwhelmed the entire healthcare system, from the unknown carrier status, poor testing capabilities to hospitals running out of ventilators for severely ill patients. There has been a variety of potential treatment modalities for the various forms of illness ranging from asymptomatic carriers to the ventilated ICU patients. These include anti-inflammatory medications, antibiotics, immune-modulators, convalescent plasma, and others. The cytokine storm that inflicts some patients can be devastating to the vital organs of the human body in the form of acute respiratory distress syndrome (ARDS), renal failure, coagulopathy, and death. CytosorbentsⓇ cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. url: https://api.elsevier.com/content/article/pii/S0147956320303708 doi: 10.1016/j.hrtlng.2020.09.007 id: cord-329985-5rji08p7 author: Robba, Chiara title: Distinct phenotypes require distinct respiratory management strategies in severe COVID-19 date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19) can cause severe respiratory failure requiring mechanical ventilation. The abnormalities observed on chest computed tomography (CT) and the clinical presentation of COVID-19 patients are not always like those of typical acute respiratory distress syndrome (ARDS) and can change over time. This manuscript aimed to provide brief guidance for respiratory management of COVID-19 patients before, during, and after mechanical ventilation, based on the recent literature and on our direct experience with this population. We identify that chest CT patterns in COVID-19 may be divided into three main phenotypes: 1) multiple, focal, possibly overperfused ground-glass opacities; 2) inhomogeneously distributed atelectasis; and 3) a patchy, ARDS-like pattern. Each phenotype can benefit from different treatments and ventilator settings. Also, peripheral macro- and microemboli are common, and attention should be paid to the risk of pulmonary embolism. We suggest use of personalized mechanical ventilation strategies based on respiratory mechanics and chest CT patterns. Further research is warranted to confirm our hypothesis. url: https://doi.org/10.1016/j.resp.2020.103455 doi: 10.1016/j.resp.2020.103455 id: cord-346062-q0trgj12 author: Robert, René title: Ethical dilemmas due to the Covid-19 pandemic date: 2020-06-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The devastating pandemic that has stricken the worldwide population induced an unprecedented influx of patients in ICUs, raising ethical concerns not only surrounding triage and withdrawal of life support decisions, but also regarding family visits and quality of end-of-life support. These ingredients are liable to shake up our ethical principles, sharpen our ethical dilemmas, and lead to situations of major caregiver sufferings. Proposals have been made to rationalize triage policies in conjunction with ethical justifications. However, whatever the angle of approach, imbalance between utilitarian and individual ethics leads to unsolvable discomforts that caregivers will need to overcome. With this in mind, we aimed to point out some critical ethical choices with which ICU caregivers have been confronted during the Covid-19 pandemic and to underline their limits. The formalized strategies integrating the relevant tools of ethical reflection were disseminated without deviating from usual practices, leaving to intensivists the ultimate choice of decision. url: https://doi.org/10.1186/s13613-020-00702-7 doi: 10.1186/s13613-020-00702-7 id: cord-276249-9opsg7p2 author: Roberto, Katrina T. title: Electroencephalographic findings in COVID-19 patients: A systematic review date: 2020-09-15 words: 3122.0 sentences: 186.0 pages: flesch: 44.0 cache: ./cache/cord-276249-9opsg7p2.txt txt: ./txt/cord-276249-9opsg7p2.txt summary: Patients with critical medical illnesses are known to be at risk for neurological complications like seizures and status epilepticus; however, the evidence is substantially limited in the context of COVID-19 infection (3) . Thus, the objective of this study was to review the EEG findings in patients diagnosed with COVID-19 infection through a systematic review of published relevant articles. We considered case reports/series, cross-sectional and cohort studies that reported on descriptive EEG findings in patients diagnosed with COVID-19 infection. Other electroencephalographic findings reported in the available literature include isoelectric EEG consistent with brain death in two cases (1.1%) in one study and fast activity superimposed on slow waves in three patients (1.7%) (22, 23) . Although it is well known that critically ill patients are at high risk for seizures and Focal non-epileptic slowing is another EEG abnormality seen in a number of COVID-19 cases. EEG findings in acutely ill patients investigated for SARS-CoV2/COVID-19: a small case series preliminary report abstract: BACKGROUND: Growing evidence of neurologic involvement seen in COVID-19 infection necessitates the pooling of neurodiagnostic findings like electroencephalography (EEG) that may guide clinical management. The objective of this study was to review the EEG findings in patients diagnosed with COVID-19 infection through a systematic review of published articles. METHODS: We systematically searched until July 25, 2020 for published articles that reported on descriptive EEG findings in patients diagnosed with COVID-19 in PUBMED by Medline, EMBASE, and CENTRAL by the Cochrane Library. RESULTS: From a total of 94 identified records, 29 relevant articles were included in this review. A total of 177 patients with COVID-19 with descriptive EEG reports were analyzed. The most common indication for EEG was unexplained altered mental status. Disturbances of background activity such as generalized and focal slowing were seen as well epileptiform abnormalities and rhythmic or periodic discharges. There were no consistent EEG findings specific to COVID-19 infection. CONCLUSION: The EEG findings in COVID-19 appear to be non-specific. Further research on the relationship of the EEG findings to the clinical state and short- or long-term prognosis of COVID-19 patients may be conducted to help clinicians discern which patients would necessitate an EEG procedure and would eventually require treatment. url: https://doi.org/10.1016/j.seizure.2020.09.007 doi: 10.1016/j.seizure.2020.09.007 id: cord-291397-look6ddt author: Roberto, Palumbo title: Current treatment of COVID-19 in renal patients: hope or hype? date: 2020-09-28 words: 5827.0 sentences: 326.0 pages: flesch: 46.0 cache: ./cache/cord-291397-look6ddt.txt txt: ./txt/cord-291397-look6ddt.txt summary: Given the lack of specific therapy about the ongoing SARS-CoV-2 infection, we conducted a brief review to summarize the mechanism of action and the potentially side effects of the treatment currently available, focusing on the effects of the drugs on renal disease at different stages in terms of therapeutic management and survival. A randomized clinical trial, handled by a Chinese group, suggested that in hospitalized adult patients with severe infection, no benefit was observed with lopinavir/ritonavir beyond standard care in terms of time to clinical improvement, reduction of mortality and safety (side effects and discontinuation of treatment) [29, 30] . Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial abstract: To date the severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), known as COVID-19, is for clinicians the most difficult global therapeutic problem. In this landscape, the management of patients with chronic kidney disease, acute kidney injury or patients undergoing immunosuppressant therapies for kidney transplant or glomerular diseases, represent a clinical challenge for nephrologists, especially in patients with severe acute lung involvement. Therefore in this setting, due to the lack of anti-COVID treatment schedules, tailored management is mandatory to reduce the side effects, as consequence of impaired renal function and drugs interactions. We report the main treatment actually used against SARS-CoV-2, underlining its possible use in the nephropatic patients and the central role of nephrologists to improve the clinical outcome. url: https://doi.org/10.1007/s11739-020-02510-0 doi: 10.1007/s11739-020-02510-0 id: cord-347696-rsjwp0b3 author: Roberts, Haydn title: Reply to the Letter to the Editor: Can Sural Fasciocutaneous Flaps Be Effective in Patients Older Than 65? date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1097/corr.0000000000001333 doi: 10.1097/corr.0000000000001333 id: cord-316845-k9zvsfvj author: Robertson, Mary M. title: Gilles de la Tourette Syndrome: advice in the times of COVID-19 date: 2020-04-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus disease (COVID-19) was identified as the cause of an outbreak of respiratory disease in China at the end of 2019. It then spread with enormous rapidity and by mid-March 2020 was declared a world pandemic. Gilles de la Tourette Syndrome (GTS) is a childhood-onset neurodevelopmental disorder with a worldwide prevalence of about 1% of the population. The clinical symptoms include multiple motor and one or more phonic (vocal) tics. Germane to this communication is that 85% of patients with GTS have associated psychiatric co-morbidities, many of which are being exacerbated in the current global health crisis. In addition, several symptoms of GTS may mimic COVID-19, such as a dry cough and sniffing (phonic tics), while other symptoms such as spitting, inappropriate touching of others and “non-obscene socially inappropriate symptoms” can potentially get patients with GTS into trouble with the law. We suggest that a clear explanation of the COVID-19 illness and GTS is important to enable colleagues of various specialities who tend to patients with GTS. It is important to acknowledge at the outset that the information available on the COVID-19 pandemic changes daily, including cases infected, deaths reported, and how various national health systems are planning and or coping or not. It is fair to say that having read the current medical and lay press we conclude that it is not easy to reassure our patients with absolute certainty. However, notwithstanding that, we hope our documentation is of some assistance. url: https://doi.org/10.12688/f1000research.23275.2 doi: 10.12688/f1000research.23275.2 id: cord-336784-24qizp9k author: Robinson, Victoria A title: Validation of the Provincial Transfer Authorization Centre database: a comprehensive database containing records of all inter-facility patient transfers in the province of Ontario date: 2006-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The Provincial Transfer Authorization Centre (PTAC) was established as a part of the emergency response in Ontario, Canada to the Severe Acute Respiratory Syndrome (SARS) outbreak in 2003. Prior to 2003, data relating to inter-facility patient transfers were not collected in a systematic manner. Then, in an emergency setting, a comprehensive database with a complex data collection process was established. For the first time in Ontario, population-based data for patient movement between healthcare facilities for a population of twelve million are available. The PTAC database stores all patient transfer data in a large database. There are few population-based patient transfer databases and the PTAC database is believed to be the largest example to house this novel dataset. A patient transfer database has also never been validated. This paper presents the validation of the PTAC database. METHODS: A random sample of 100 patient inter-facility transfer records was compared to the corresponding institutional patient records from the sending healthcare facilities. Measures of agreement, including sensitivity, were calculated for the 12 common data variables. RESULTS: Of the 100 randomly selected patient transfer records, 95 (95%) of the corresponding institutional patient records were located. Data variables in the categories patient demographics, facility identification and timing of transfer and reason and urgency of transfer had strong agreement levels. The 10 most commonly used data variables had accuracy rates that ranged from 85.3% to 100% and error rates ranging from 0 to 12.6%. These same variables had sensitivity values ranging from 0.87 to 1.0. CONCLUSION: The very high level of agreement between institutional patient records and the PTAC data for fields compared in this study supports the validity of the PTAC database. For the first time, a population-based patient transfer database has been established. Although it was created during an emergency situation and data collection is dependent on front-line medical workers, the PTAC data has achieved a high level of validity, perhaps even higher than many purpose built databases created during non-emergency settings. url: https://www.ncbi.nlm.nih.gov/pubmed/17026763/ doi: 10.1186/1472-6963-6-129 id: cord-016235-2lhrkmrv author: Roden, Anja C. title: Lung date: 2010-05-17 words: 12865.0 sentences: 674.0 pages: flesch: 35.0 cache: ./cache/cord-016235-2lhrkmrv.txt txt: ./txt/cord-016235-2lhrkmrv.txt summary: Unlike the situation with heart transplant recipients, chronic vascular rejection in lung transplants has not resulted in graft loss; however, some patients develop pulmonary hypertension particularly those with BOS [92, 111] . However, based on the link between acute rejection and development of BOS, surveillance transbronchial biopsies in asymptomatic lung transplant recipients has become common practice in many large lung transplantation centers because evidence suggests that patients who have multiple episodes of low grade (A1) lesions within the first 12 months posttransplantation develop early onset BOS. A study [49] in which surveillance transbronchial biopsies were performed at 3, 6, 9, and 12 weeks posttransplantation, at the time of symptoms, and for follow-up of acute rejection or CMV pneumonia showed that patients who develop acute small airways rejection within the first year after transplantation are at risk of development of BOS at 1.76, 3.3, and 5.5 years after detection of B3/ B4 lesion (by 1996 ISHLT criteria, see Table 7 .2), B2 lesion or B0/B1 lesion, respectively. abstract: Experiments with animals in the 1940 and 1950s demonstrated that lung transplantation was technically possible [33]. In 1963, Dr. James Hardy performed the first human lung transplantation. The recipient survived 18 days, ultimately succumbing to renal failure and malnutrition [58]. From 1963 through 1978, multiple attempts at lung transplantation failed because of rejection and complications at the bronchial anastomosis. In the 1980s, improvements in immunosuppression, especially the introduction of cyclosporin A, and enhanced surgical techniques led to renewed interest in organ transplantation. In 1981, a 45-year-old-woman received the first successful heart–lung transplantation for idiopathic pulmonary arterial hypertension (IPAH) [106]. She survived 5 years after the procedure. Two years later the first successful single lung transplantation for idiopathic pulmonary fibrosis (IPF) [128] was reported, and in 1986 the first double lung transplantation for emphysema [25] was performed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120462/ doi: 10.1007/978-3-540-79343-4_7 id: cord-281039-a7q5nzwn author: Rodilla, Enrique title: Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 date: 2020-09-28 words: 4806.0 sentences: 246.0 pages: flesch: 45.0 cache: ./cache/cord-281039-a7q5nzwn.txt txt: ./txt/cord-281039-a7q5nzwn.txt summary: Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). First, a previous diagnosis of HT increased the risk of all-cause death in COVID-19 patients who required hospitalization on the order of approximately 20% and independently of age and other cardiovascular comorbidities, such as HF and atrial fibrillation. Second, previous treatment with ACEIs/ARBs in hypertensive patients was not associated with a higher risk of all-cause mortality in hypertensive hospitalized COVID-19 patients compared to other antihypertensive drugs. abstract: It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs. url: https://www.ncbi.nlm.nih.gov/pubmed/32998337/ doi: 10.3390/jcm9103136 id: cord-321030-isc3p46t author: Rodriguez Socarrás, Moises title: Telemedicine and Smart Working: Recommendations of the European Association of Urology date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: CONTEXT: Telemedicine provides remote clinical support using technological tools. It may facilitate health care delivery while reducing unnecessary visits to the clinic. The coronavirus disease 2019 (COVID-19) outbreak has caused an abrupt change in our daily urological practice, converting many of us to be reliant on telehealth. OBJECTIVE: To provide practical recommendations for effective use of technological tools in telemedicine. EVIDENCE ACQUISITION: A Medline-based and gray literature search was conducted through April 2020. We selected the most relevant articles related to “telemedicine” and “smart working” that could provide important information. EVIDENCE SYNTHESIS: Telemedicine refers to the use of electronic information and telecommunications tools to provide remote clinical health care support. Smart working is a model of work that uses new or existing technologies to improve performance. Telemedicine is becoming a useful invaluable tool during and even beyond the COVID-19 pandemic. It is time for us to formalize the place of telemedicine in routine urological practice, and it is our responsibility to adapt and learn about all the tools and possible strategies for their optimal implementation during the pandemic to ensure that the quality of care received by patients and the outcomes of patients and their families are of the highest standard. CONCLUSIONS: Telemedicine facilitates specialized urological clinical support at a distance, solves problems of limitations in mobility, reduces unnecessary visits to clinics, and is useful for reducing the risk of viral transmission in the current COVID-19 outbreak. Furthermore, both personal and societal considerations may favor continued use of telemedicine, even beyond the COVID-19 pandemic. PATIENT SUMMARY: Telemedicine in urology offers specialized remote clinical support to patients, similar to face-to-face visits. It is very useful for reducing unnecessary visits to the clinic, as well as reducing the risk of contagion in the current coronavirus disease 2019 (COVID-19) pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32654801/ doi: 10.1016/j.eururo.2020.06.031 id: cord-349263-mmfrqyrc author: Rodríguez, A. title: Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic date: 2020-11-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective To describe the clinical and respiratory characteristics of a cohort of 43 patients with COVID-19 after an evolutive period of 28 days. Design A prospective, single-center observational study was carried out. Setting Intensive care. Patients Patients admitted due to COVID-19 and respiratory failure. Interventions None. Variables Automatic recording was made of demographic variables, severity parameters, laboratory data, assisted ventilation (HFO: high-flow oxygen therapy and IMV: invasive mechanical ventilation), oxygenation (PaO2, PaO2/FiO2) and complications. The patients were divided into three groups: survivors (G1), deceased (G2) and patients remaining under admission (G3). The chi-squared test or Fisher exact test (categorical variables) was used, along with the Mann-Whitney U-test or Wilcoxon test for analyzing the differences between medians. Statistical significance was considered for p < 0.05. Results A total of 43 patients were included (G1 = 28 [65.1%], G2 = 10 [23.3%] and G3 = 5[11.6%]), with a mean age of 65 years (range 52-72), 62% males, APACHE II 18 (15-24), SOFA 6 (4-7). Arterial hypertension (30.2%) and obesity (25.6%) were the most frequent comorbidities. High-flow oxygen therapy was used in 62.7% of the patients, with failure in 85%. In turn, 95% of the patients required IMV and 85% received ventilation in prone decubitus. In the general population, initial PaO2/FiO2 improved after 7 days (165 [125-210] vs.194 [153-285]; p = 0.02), in the same way as in G1 (164 [125-197] vs. 207 [160-294]; p = 0.07), but not in G2 (163 [95-197] vs. 135 [85-177]). No bacterial coinfection was observed. The incidence of IMV-associated pneumonia was high (13 episodes/1000 days of IMV). Conclusions Patients with COVID-19 require early IMV, a high frequency of ventilation in prone decubitus, and have a high incidence of failed HFO. The lack of improvement of PaO2/FiO2 at 7 days could be a prognostic marker. url: https://www.sciencedirect.com/science/article/pii/S2173572720301739 doi: 10.1016/j.medine.2020.05.005 id: cord-031497-pp0p3en6 author: Rodríguez-Fuster, Alberto title: Tracheal trauma in the context of the current infection by COVID-19. About 2 cases() date: 2020-09-06 words: 1153.0 sentences: 79.0 pages: flesch: 53.0 cache: ./cache/cord-031497-pp0p3en6.txt txt: ./txt/cord-031497-pp0p3en6.txt summary: Various authors and scientific societies have recommended limiting the number of airway procedures and manipulations and introducing stringent protection measures for health personnel in order to minimize the risk of infection. [2] [3] [4] We report 2 cases of patients diagnosed with SARS-CoV-2 infection and tracheal iatrogenic rupture following airway manipulation. She required OTI + MV for respiratory failure, and during the procedure she incurred a tracheal lesion confirmed by computed tomography and fiberoptic bronchoscopy to be a rupture of the pars membranacea measuring approximately 2 cm. To minimize the risk of aerosols, the patient was maintained in complete muscle relaxation throughout the procedure; preoxygenation and ventilatory pauses-apneas-were performed (as far as possible) in accordance with the recommendations described for tracheotomy. Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations Tracheal trauma after difficult airway management in morbidly obese patients with COVID-19 abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474846/ doi: 10.1016/j.arbr.2020.08.007 id: cord-282474-74273qgk author: Roehrig, Stefan title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-11 words: 2881.0 sentences: 190.0 pages: flesch: 55.0 cache: ./cache/cord-282474-74273qgk.txt txt: ./txt/cord-282474-74273qgk.txt summary: title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial OBJECTIVES: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We define ARDS according to the "Berlin" definition integrating the oxygenation index (P/F ratio), the level of Positive End Expiratory Pressure (PEEP), radiological and clinical findings. TRIAL REGISTRATION: The protocol was registered before starting subject recruitment under the title: "Flow controlled ventilation in ARDS associated with COVID-19" in ClinicalTrials.org with the registration number: NCT04399317. Although the severely ill patients will need intubation and invasive ventilation according to ARDS treatment strategies including low tidal volumes and low end-expiratory pressures, not all patients recover their pulmonary function [3, 4] . abstract: OBJECTIVES: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We define ARDS according to the “Berlin” definition integrating the oxygenation index (P/F ratio), the level of Positive End Expiratory Pressure (PEEP), radiological and clinical findings. TRIAL DESIGN: This is a prospective, randomized (1:1 ratio), parallel group feasibility study in adult patients with proven COVID-19 associated ARDS. PARTICIPANTS: All adult patients admitted to the ICU of Hamad Medical Corporation facilities in Qatar because of COVID-19 infection who develop moderate to severe ARDS are eligible. The inclusion criteria are above 18 years of age, proven COVID-19 infection, respiratory failure necessitating intubation and mechanical ventilation, ARDS with a P/F ratio of at least 200mmHg or less and a minimum PEEP 5cmH2O, BMI less 30 kg/ m2. The following exclusion criteria: no written consent, chronic respiratory disease, acute or chronic cardiovascular disease, pregnancy or need for special therapy (prone position and/or Extracorporeal membrane oxygenation). INTERVENTION AND COMPARATOR: After randomisation, the group A patients will be ventilated with the test-device for 48 hours. The settings will be started with the pre-existing-PEEP. The upper pressure will be determined to achieve a tidal volume of 6 ml/kg lean body mass, while the respiratory rate will be set to maintain an arterial pH above 7.2. In group B, the ventilator settings will be adjusted by the attending ICU team in accordance with lung-protective ventilation strategy. All other treatment will be unchanged and according to our local policies/guidelines. MAIN OUTCOMES: The primary end point is PaO2. As this is a dynamic parameter, we will record it every 6-8 hours and analyse it sequentially. RANDOMISATION: The study team screens the ventilated patients who fulfil the inclusion criteria and randomise using a 1:1 allocation ratio after consenting using a closed envelope method. The latter were prepared and sealed in advance by an independent person. BLINDING (MASKING): Due to the technical nature of the study (use of a specific ventilator) blinding is only possible for the data-analysts and the patients. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): The sample size calculation based on the assumption of an effect size (change in PaO2) of 1.5 SDS in the primary endpoint (PaO2), an intended power of 80%, an alpha error of 5% and an equal sample ratio results in n=7 patients needed to treat. However, to compensate for dropouts we will include 10 patients in each group, which means in total 20 patients. TRIAL STATUS: The local registration number is MRC-05-018 with the protocol version number 3. The date of approval is 14(th) April 2020. Recruitment began 28th May 2020 and is expected to end in September 2020. TRIAL REGISTRATION: The protocol was registered before starting subject recruitment under the title: “Flow controlled ventilation in ARDS associated with COVID-19” in ClinicalTrials.org with the registration number: NCT04399317. Registered on 22 May 2020. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://doi.org/10.1186/s13063-020-04708-1 doi: 10.1186/s13063-020-04708-1 id: cord-252473-i4pmux28 author: Rogers, Sharon title: Why can''t I visit? The ethics of visitation restrictions – lessons learned from SARS date: 2004-08-31 words: 1908.0 sentences: 83.0 pages: flesch: 42.0 cache: ./cache/cord-252473-i4pmux28.txt txt: ./txt/cord-252473-i4pmux28.txt summary: It could be argued that visitation restrictions, in light of a potential outbreak of a contagious disease, are ethically sound because of the compelling need to protect public health. In a health care institution, visitation restrictions not only affect inpatients but also have an impact on ambulatory patients who must come for diagnostic tests or interventions and who, if deprived access, might develop urgent or emergent conditions. Furthermore, to be consistent with expectations of transparency, the criteria by which exceptionality to the rules of visitation restriction exists should also be published openly throughout the organization for staff, patients and visitors. For example, although current policy allows for specific times of visitation and numbers of visitors per day, a sudden outbreak might dictate a quick lockdown of the facility without patients or family members receiving prior notice. It is ethical to accept that public health protection trumps individual rights to liberal visitation. abstract: Patients want, need and expect that their relatives will be able to visit them during inpatient admissions or accompany them during ambulatory visits. The sudden outbreak of severe acute respiratory syndrome (SARS), or a similar contagious pathogen, will restrict the number of people entering the hospital. The ethical values that underlie visitor restrictions are discussed here. url: https://www.ncbi.nlm.nih.gov/pubmed/15469583/ doi: 10.1186/cc2930 id: cord-335593-cjb0daps author: Romagnolo, Alberto title: Neurological comorbidity and severity of COVID-19 date: 2020-08-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Neurological symptoms of COVID-19 patients have been recently described. However, no comprehensive data have been reported on pre-existing neurological comorbidities and COVID-19. This study aims at evaluating the prevalence of neurological comorbidities, and their association with COVID-19 severity. METHODS: We evaluated all consecutive patients admitted to the Emergency Room (ER) of our hospital between the 3rd March and the 14th April 2020, and diagnosed with COVID-19. Data on neurological and non-neurological diseases were extracted, as well as data on demographic characteristics and on severity degree of COVID-19. The prevalence of neurological comorbidities was calculated, and multivariate binary logistic regression analyses were used to estimate the association between neurological diseases and COVID-19 severity. RESULTS: We included 344 patients. Neurological comorbidities accounted for 22.4% of cases, with cerebrovascular diseases and cognitive impairment being the most frequent. Neurological comorbidity resulted independently associated with severe COVID-19 (OR 2.305; p = 0.012), as well as male gender (p = 0.001), older age (p = 0.001), neoplastic diseases (p = 0.039), and arterial hypertension (p = 0.045). When neurological comorbidity was associated with non-neurological comorbidities, the OR for severe COVID-19 rose to 7.394 (p = 0.005). Neurological patients, in particular cerebrovascular and cognitively impaired ones, received more respiratory support indication. CONCLUSION: Neurological comorbidities represent a significant determinant of COVID-19 severity, deserving a thorough evaluation since the earliest phases of infection. The vulnerability of patients affected by neurological diseases should suggest a greater attention in targeting this population for proactive viral screening. url: https://doi.org/10.1007/s00415-020-10123-y doi: 10.1007/s00415-020-10123-y id: cord-307808-0t6sw0zp author: Romanick-Schmiedl, Sue title: Telemedicine — maintaining quality during times of transition date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 crisis has accelerated the adoption of telemedicine, presenting challenges and opportunities for clinicians trying to manage diverse, and not only pandemic-related, health conditions. Here, we consider some limitations of telemedicine and offer a perspective on how clinicians can adapt to working in different health-care delivery systems. url: https://doi.org/10.1038/s41572-020-0185-x doi: 10.1038/s41572-020-0185-x id: cord-273408-jtpaue0z author: Romeyke, Tobias title: COVID-19 Case Report: An 84-Year-Old Man with Exacerbation of Multiple Comorbidities Due to COVID-19 Managed by a Multidisciplinary Team Using Patient-Reported Outcomes date: 2020-08-21 words: 3045.0 sentences: 201.0 pages: flesch: 48.0 cache: ./cache/cord-273408-jtpaue0z.txt txt: ./txt/cord-273408-jtpaue0z.txt summary: Patient: Male, 84-year-old Final Diagnosis: Acute bronchitis • chronic multiple pain with spondylosis with radiculopathy: lumbar region • chronic renal failure CKD 4 • derailed type 2 diabetes mellitus • diabetes mellitus type 2 • eart failure • hyperuricaemia • progressive aortic stenosis • pulmonary hypertension • SARS-CoV2 Symptoms: Appetite loss • fever • pain • sore throat Medication: — Clinical Procedure: — Specialty: General and Internal Medicine OBJECTIVE: Unusual clinical course BACKGROUND: When treating patients with comorbidities who are infected with severe acute respiratory syndrome as a result of SARS-CoV-2, it is crucial to offer multidisciplinary treatment that takes into consideration all of the health conditions with which they have been diagnosed. We collected clinical and patient-reported data on quality of life, physical functions, the sensation of pain, psychological well-being, and symptoms while taking into account the degree of chronicity of the conditions, the level of the patient''s pain, and his hospitalization in an isolation ward. abstract: Patient: Male, 84-year-old Final Diagnosis: Acute bronchitis • chronic multiple pain with spondylosis with radiculopathy: lumbar region • chronic renal failure CKD 4 • derailed type 2 diabetes mellitus • diabetes mellitus type 2 • eart failure • hyperuricaemia • progressive aortic stenosis • pulmonary hypertension • SARS-CoV2 Symptoms: Appetite loss • fever • pain • sore throat Medication: — Clinical Procedure: — Specialty: General and Internal Medicine OBJECTIVE: Unusual clinical course BACKGROUND: When treating patients with comorbidities who are infected with severe acute respiratory syndrome as a result of SARS-CoV-2, it is crucial to offer multidisciplinary treatment that takes into consideration all of the health conditions with which they have been diagnosed. In particular, clinicians should not lose sight of the patient experience, which we can be assessed with the help of patient-reported outcomes (PROs). CASE REPORT: An 84-year-old man infected with SARS-CoV-2 was already suffering from multiple health conditions, including Type 2 diabetes mellitus. He most likely was receiving cortisone therapy and had chronic pain with spondylosis with radiculopathy, bilateral gonarthrosis following total knee replacement, malaise, and fatigue. The patient received acute inpatient care in a hospital that provides complementary medical therapies. We collected clinical and patient-reported data on quality of life, physical functions, the sensation of pain, psychological well-being, and symptoms while taking into account the degree of chronicity of the conditions, the level of the patient’s pain, and his hospitalization in an isolation ward. We stabilized clinical parameters related to the patient’s main underlying health conditions (blood glucose and pain levels and oxygen saturation). The PROs we collected demonstrated a significant improvement on discharge. CONCLUSIONS: Applying PROs can be helpful in obtaining a more comprehensive picture of a patient with COVID-19, in which “the patient is given a voice,” in addition to being assessed by others. The knowledge gained can then be made available to the interdisciplinary treatment team to be incorporated into the treatment plan. url: https://doi.org/10.12659/ajcr.926694 doi: 10.12659/ajcr.926694 id: cord-271358-5666nsb9 author: Roncon, Loris title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-06 words: 420.0 sentences: 33.0 pages: flesch: 47.0 cache: ./cache/cord-271358-5666nsb9.txt txt: ./txt/cord-271358-5666nsb9.txt summary: authors: Roncon, Loris; Zuin, Marco; Rigatelli, Gianluca title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment Doubtless this is a very important issue in the management of COVID-19 patients, but can heparin be administered in all cases? Should we consider a dose reduction in those patients with a severe thrombocytopenia? In this regard, it is would be important also to establish different anticoagulant strategies in COVID-19 patients with thrombocytopenia which is frequently observed in clinical practice. This article does not contain any studies with human participants performed by any of the authors. Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis Thrombocytopenia and its association with mortality in patients with COVID-19 Loris Roncon and Marco Zuin are equally contributed to the manuscript as first author abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32378044/ doi: 10.1007/s11739-020-02358-4 id: cord-279667-ikfduu2k author: Ronnje, Louise title: Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery date: 2020-09-04 words: 3361.0 sentences: 207.0 pages: flesch: 50.0 cache: ./cache/cord-279667-ikfduu2k.txt txt: ./txt/cord-279667-ikfduu2k.txt summary: title: Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery Severe COVID-19 promptly improved by the termination of the pregnancy or atypical HELLP (Hemolysis, Elevated Liver Enzymes and Low Platelet Count) exacerbated by concomitant COVID-19 infection could not be ruled out. CONCLUSIONS: This case adds to the growing body of evidence which raises concerns about the possible negative maternal outcomes of COVID-19 infection during pregnancy and advocates for pregnant women to be recognized as a vulnerable group during the current pandemic. We report a case of severe COVID-19 during in third trimester pregnancy, which led to an emergency Caesarean section and preterm delivery at 32 + 6 weeks of gestational age. Atypical presentation of HELLP could not be ruled out and the importance of a multidisciplinary team in the treatment and management of severe COVID-19 during pregnancy is critical for positive patient outcome. abstract: BACKGROUND: It has been proposed that pregnant women and their fetuses may be particularly at risk for poor outcomes due to the coronavirus (COVID-19) pandemic. From the few case series that are available in the literature, women with high risk pregnancies have been associated with higher morbidity. It has been suggested that pregnancy induced immune responses and cardio-vascular changes can exaggerate the course of the COVID-19 infection. CASE PRESENTATION: A 26-year old Somalian woman (G2P1) presented with a nine-day history of shortness of breath, dry cough, myalgia, nausea, abdominal pain and fever. A nasopharyngeal swab returned positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Her condition rapidly worsened leading to severe liver and coagulation impairment. An emergency Caesarean section was performed at gestational week 32 + 6 after which the patient made a rapid recovery. Severe COVID-19 promptly improved by the termination of the pregnancy or atypical HELLP (Hemolysis, Elevated Liver Enzymes and Low Platelet Count) exacerbated by concomitant COVID-19 infection could not be ruled out. There was no evidence of vertical transmission. CONCLUSIONS: This case adds to the growing body of evidence which raises concerns about the possible negative maternal outcomes of COVID-19 infection during pregnancy and advocates for pregnant women to be recognized as a vulnerable group during the current pandemic. url: https://doi.org/10.1186/s12884-020-03172-8 doi: 10.1186/s12884-020-03172-8 id: cord-300344-57vxlctl author: Roof, Kevin S. title: Virtual On Treatment Visits: Implementation, Patient Perspectives, Barriers, Limitations, Benefits and Opportunities. date: 2020-10-16 words: 4337.0 sentences: 241.0 pages: flesch: 52.0 cache: ./cache/cord-300344-57vxlctl.txt txt: ./txt/cord-300344-57vxlctl.txt summary: PURPOSE: To report our initial experience with weekly tele-video "virtual" on treatment visits (vOTVs), describe the logistics of implementation, report results of patient and physician surveys, and discuss barriers, limitations, and benefits of vOTVs during the COVID-19 pandemic. Physicians participating in the vOTVs felt very comfortable in their ability to manage patients though this platform (5.0), and on average did not report any difference in terms of efficiency of visits (3.0). Our experience suggests that vOTVs can be implemented rapidly using available technology, and with a high degree of patient and physician satisfaction during this pandemic with similar efficiency to in person OTVs. COVID-19 can cause serious illness or death, particularly in high risk groups. In an effort to further minimize patient, and staff risk of COVID-19 exposure, the American Society for Radiation Oncology (ASTRO) lobbied for coverage of virtual on treatment visits (vOTVs). abstract: PURPOSE: To report our initial experience with weekly tele-video “virtual” on treatment visits (vOTVs), describe the logistics of implementation, report results of patient and physician surveys, and discuss barriers, limitations, and benefits of vOTVs during the COVID-19 pandemic. METHOD: Virtual OTVs were piloted at two centers, and within one week expanded to 4 additional centers. Patients participating in vOTVs were surveyed about their satisfaction with vOTVs, quality of vOTVs, and confidence in their physician’s ability to manage their care through vOTVs, as well as their support of, and preferences related to vOTVs. Participating physicians were also surveyed about their comfort and satisfaction with vOTVs. Medical Directors at non-participating centers within our network were surveyed regarding their reasoning for not using vOTVs. RESULTS: In week 1, 72 of 81 patients between 2 pilot centers were seen using vOTVs. In week 2, 189 of 211 patients were seen using vOTVs at 6 centers. Patient satisfaction and confidence in their physician’s ability to address their concerns through the vOTV was high at 4.75 on a 5-point scale. Patients were overall very supportive (4.67) and found the quality of the visits to be as good as, or better, than their prior in person weekly OTV (3.75). Physicians participating in the vOTVs felt very comfortable in their ability to manage patients though this platform (5.0), and on average did not report any difference in terms of efficiency of visits (3.0). CONCLUSIONS: Virtual OTVs were easy to implement and well received by patients and participating physicians. Our experience suggests that vOTVs can be implemented rapidly using available technology, and with a high degree of patient and physician satisfaction during this pandemic with similar efficiency to in person OTVs. url: https://www.sciencedirect.com/science/article/pii/S2452109420302682?v=s5 doi: 10.1016/j.adro.2020.09.019 id: cord-334408-w0yxz7zb author: Rosca, Paola title: Isolating the isolated: Implications of COVID-19 quarantine measures on in-patient detoxification treatment for substance use disorders date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32646714/ doi: 10.1016/j.drugpo.2020.102830 id: cord-261455-uejtwgar author: Roschewski, Mark title: Inhibition of Bruton tyrosine kinase in patients with severe COVID-19 date: 2020-06-05 words: 7677.0 sentences: 369.0 pages: flesch: 40.0 cache: ./cache/cord-261455-uejtwgar.txt txt: ./txt/cord-261455-uejtwgar.txt summary: Acalabrutinib, a selective BTK inhibitor, was administered off-label to 19 patients hospitalized with severe COVID-19 (11 on supplemental oxygen; 8 on mechanical ventilation), 18 of whom had increasing oxygen requirements at baseline. This prospective off-label clinical study includes 19 hospitalized patients with severe COVID-19 who received off-label acalabrutinib between March 20, 2020 (date of treatment of the first patient) through April 10, 2020 with formal data collection completed on April 23, 2020 (Table S1 ). Our laboratory studies of ex vivo blood samples from patients hospitalized with COVID-19 revealed significantly elevated BTK phosphorylation in peripheral blood monocytes compared with healthy volunteers, demonstrating that the target of acalabrutinib is activated in these innate immune cells. BTK activation occurs in macrophages when TLRs bind single-stranded RNA, as may occur in SARS-CoV-2 infection, leading to NF-κB-dependent expression of multiple inflammatory cytokines and chemokines, including IL-6 which we observed was induced in COVID-19 monocytes and decreased in plasma following acalabrutinib treatment (Fig. 1) . abstract: Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation. Bruton tyrosine kinase (BTK) regulates macrophage signaling and activation. Acalabrutinib, a selective BTK inhibitor, was administered off-label to 19 patients hospitalized with severe COVID-19 (11 on supplemental oxygen; 8 on mechanical ventilation), 18 of whom had increasing oxygen requirements at baseline. Over a 10-14 day treatment course, acalabrutinib improved oxygenation in a majority of patients, often within 1-3 days, and had no discernable toxicity. Measures of inflammation – C-reactive protein and IL-6 – normalized quickly in most patients, as did lymphopenia, in correlation with improved oxygenation. At the end of acalabrutinib treatment, 8/11 (72.7%) patients in the supplemental oxygen cohort had been discharged on room air, and 4/8 (50%) patients in the mechanical ventilation cohort had been successfully extubated, with 2/8 (25%) discharged on room air. Ex vivo analysis revealed significantly elevated BTK activity, as evidenced by autophosphorylation, and increased IL-6 production in blood monocytes from patients with severe COVID-19 compared with blood monocytes from healthy volunteers. These results suggest that targeting excessive host inflammation with a BTK inhibitor is a therapeutic strategy in severe COVID-19 and has led to a confirmatory international prospective randomized controlled clinical trial. url: https://www.ncbi.nlm.nih.gov/pubmed/32503877/ doi: 10.1126/sciimmunol.abd0110 id: cord-293634-4rryqbnu author: Rosen, Kelsey title: Delivering Telerehabilitation to COVID-19 Inpatients:A Retrospective Chart Review Suggests It Is a Viable Option date: 2020-07-16 words: 3592.0 sentences: 185.0 pages: flesch: 34.0 cache: ./cache/cord-293634-4rryqbnu.txt txt: ./txt/cord-293634-4rryqbnu.txt summary: Based on the algorithm, COVID-19 inpatients were selected to receive telerehabilitation if they could ambulate independently, could use technology, had stable vital signs, required minimal supplemental oxygen, and were cognitively intact. The purpose of the inpatient telerehabilitation PT program for COVID-19 patients was to safely assess barriers to discharge, deliver patient education, and provide a home exercise program (HEP) all while minimizing staff exposure. Success of the inpatient telerehabilitation program was determined based on the ability to create an algorithm, train staff, deliver education efficiently, maintain patient and staff safety during interventions, and ensure patients discharged home safely. Despite these limitations, we believe that this retrospective review provides preliminary data on how to implement an inpatient telerehabilitation program and suggests that selected COVID-19 patients can be discharged successfully after this method of treatment. abstract: BACKGROUND: Guidelines for physical therapy management of patients hospitalized with COVID-19 recommend limiting physical therapists’ contact with patients when possible. Telehealth has been viewed as “electronic personal protective equipment” during the COVID-19 pandemic; although telerehabilitation has been shown to be effective with outpatients, it is unknown whether it is a viable option for hospitalized patients. PURPOSE: Our facility developed an algorithm for the use of a physical therapy telerehabilitation program for inpatients with COVID-19. We sought to investigate the safety and viability of the program. METHODS: We conducted a retrospective chart review of patients admitted with a diagnosis of COVID-19 who received either telerehabilitation only or a combination of telerehabilitation and in-person rehabilitation. Based on the algorithm, COVID-19 inpatients were selected to receive telerehabilitation if they could ambulate independently, could use technology, had stable vital signs, required minimal supplemental oxygen, and were cognitively intact. We analyzed data of inpatients who received telerehabilitation only, which included patient education, therapeutic exercises, and breathing techniques. RESULTS: Of 33 COVID-19 inpatients who received telerehabilitation, in-person rehabilitation, or a combination of the two, 12 patients received telerehabilitation only (age range, 33 to 65 years; all but one male). They demonstrated independence with their individualized home exercise programs in one to two sessions, did not require an in-person rehabilitation consultation, did not require increased oxygen, experienced no exacerbation of symptoms, and were discharged home. CONCLUSIONS: Inpatient telerehabilitation appears to be a viable option for selected hospitalized patients with COVID-19 and may be a safe way of delivering inpatient rehabilitation to isolated or at-risk populations. At our hospital, the use of inpatient telerehabilitation reduced staff exposure while providing important education and services to patients. To our knowledge, no studies have investigated the use of telerehabilitation for hospitalized patients, including those with COVID-19. Our findings suggest that this innovative approach warrants further study. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11420-020-09774-4) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s11420-020-09774-4 doi: 10.1007/s11420-020-09774-4 id: cord-339474-tsdq1rgz author: Rosen, Tony title: Managing Older Adults with Presumed COVID‐19 in the Emergency Department: A Rational Approach to Rationing date: 2020-07-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1111/jgs.16651 doi: 10.1111/jgs.16651 id: cord-286403-gdkwabcj author: Rosovsky, Rachel P. title: Diagnosis and Treatment of Pulmonary Embolism During the COVID-19 Pandemic: A Position Paper from the National PERT Consortium date: 2020-08-27 words: 2364.0 sentences: 146.0 pages: flesch: 40.0 cache: ./cache/cord-286403-gdkwabcj.txt txt: ./txt/cord-286403-gdkwabcj.txt summary: title: Diagnosis and Treatment of Pulmonary Embolism During the COVID-19 Pandemic: A Position Paper from the National PERT Consortium However, the unique aspects of this virus confound both the diagnosis and treatment of PE, and thus require modification of established algorithms.1-6 Important considerations include adjustment of diagnostic modalities, incorporation of the pro-thrombotic contribution of COVID-19, management of two critical cardio-respiratory illnesses in the same patient, and protecting patients and health care workers while providing optimal care. The National Pulmonary Embolism Response Team (PERT) Consortium, the largest organization in the world specifically dedicated to improving outcomes in PE and advancing the science around this disease, recently published consensus recommendations for the diagnosis, treatment and follow-up for patients with acute PE. Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report abstract: The co-existence of COVID-19 and PE, two life threatening illnesses, in the same patient presents a unique challenge. Recent guidelines have delineated how best to diagnose and manage patients with PE. However, the unique aspects of this virus confound both the diagnosis and treatment of PE, and thus require modification of established algorithms.1-6 Important considerations include adjustment of diagnostic modalities, incorporation of the pro-thrombotic contribution of COVID-19, management of two critical cardio-respiratory illnesses in the same patient, and protecting patients and health care workers while providing optimal care. The benefits of a team-based approach for decision-making and coordination of care, such as that offered by pulmonary embolism response teams (PERT), has become more evident in this crisis. The importance of careful followup care also is underscored for patients with these two diseases with long-term effects. This position paper from the PERT Consortium specifically addresses issues related to the diagnosis and management of PE in the COVID-19 patient. url: https://www.sciencedirect.com/science/article/pii/S0012369220342872?v=s5 doi: 10.1016/j.chest.2020.08.2064 id: cord-252452-wwkw1uyi author: Rossi, Rosario title: Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action date: 2020-10-03 words: 1331.0 sentences: 79.0 pages: flesch: 47.0 cache: ./cache/cord-252452-wwkw1uyi.txt txt: ./txt/cord-252452-wwkw1uyi.txt summary: As a further analysis, to investigate whether the intensity of action of statins could influence the risk of mortality, we divided our 42 patients taking statins into two subgroups, based on the drug''s intensity of action, according to the ACC/AHA Classification [5] . The comparison between the survival curves, in contrast to patients who did not take statins, showed no significant differences (Fig. 1b) . The comparison between the survival curves, in contrast to patients who did not take statins, indicated a significant difference between groups. In a recent study, no significant differences in statin chronic assumption were found in COVID-19 patients who developed a cardiac injury, even if this population showed an increased mortality risk in the brief period [11] . The comparison between the survival curves, in contrast to patients who did not take statins, showed no significant differences. The comparison between the survival curves, in contrast to patients who do not take statins, showed a significant differences role against the virus. abstract: nan url: https://doi.org/10.1007/s11739-020-02504-y doi: 10.1007/s11739-020-02504-y id: cord-273869-buavj9mm author: Rosés-Gibert, Pau title: Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain date: 2020-09-08 words: 1892.0 sentences: 135.0 pages: flesch: 49.0 cache: ./cache/cord-273869-buavj9mm.txt txt: ./txt/cord-273869-buavj9mm.txt summary: title: Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain METHODS: A retrospective descriptive study was performed collecting data on 36 patients under 14 years old, presenting suspicious acral skin manifestations for coronavirus disease 2019 (COVID-19). The management of patients presenting chilblain-like lesions and acral purpuric macules is not well established. Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients COVID-19) infection-induced chilblains: a case report with histopathological findings Chilblain and acral purpuric lesions in Spain during covid confinement: retrospective analysis of 12 cases Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients Chilblains-like lesions in children following suspected COVID-19 infection Assessment of acute acral lesions in a case series of children and adolescents during the COVID-19 pandemic abstract: BACKGROUND: To describe the cutaneous acral findings in a pediatric population noticed during this pandemic. METHODS: A retrospective descriptive study was performed collecting data on 36 patients under 14 years old, presenting suspicious acral skin manifestations for coronavirus disease 2019 (COVID-19). RESULTS: Patients were mostly male (63.8%). The mean age was 11.11 years. 66.67% of patients showed erythematous papules, and 44.44% purpuric macules. Feet were affected in 97.22% of patients and hands in 5.55%. Lesions were asymptomatic in 50% of patients. 30.55% of patients showed extracutaneous findings, preceding skin lesions in 12.62 days. Seven patients underwent specific severe acute coronavirus 2 (SARS-CoV-2) testing; all of these patients tested negative. CONCLUSIONS: The association between these symptoms and SARS-CoV-2 remains unclear. We recommend using these manifestations as a sign of SARS-CoV-2 infection in children. This could lead to the examination of asymptomatic and mildly symptomatic children so that contagions may be avoided. url: https://www.ncbi.nlm.nih.gov/pubmed/32901377/ doi: 10.1007/s12519-020-00390-0 id: cord-265967-y4639p9m author: Rottenberg, Yakir title: Geriatric patient-centered care during the COVID-19: Provision of interactions vs. the imposition of isolation date: 2020-06-18 words: 458.0 sentences: 40.0 pages: flesch: 59.0 cache: ./cache/cord-265967-y4639p9m.txt txt: ./txt/cord-265967-y4639p9m.txt summary: title: Geriatric patient-centered care during the COVID-19: Provision of interactions vs. 1 Older persons diagnosed with cancer, their families, and the medical staff face a meticulous trade-off between aggressive physical/social distancing and maintaining as close an interaction with family and community life as possible. This seems to contradict older patients'' preference for autonomy and decision-making about their life and health. It can be hypothesized that the COVID-19 virus and the chronic condition of cancer goals of the older patients population increases with age. In most families, the current isolation policy and total uncertainty alongside the fears of older patients with cancer becoming infected contradict the basic physical needs of security, namely, the need to touch, embrace, hear the sound of a familiar voice, and not be abandoned. The illness trajectory of elderly cancer patients across cultures: SIOG position paper Palliative care of cancer in the older patient abstract: nan url: https://doi.org/10.1016/j.jgo.2020.06.016 doi: 10.1016/j.jgo.2020.06.016 id: cord-280984-2j8ckz14 author: Roux, CH title: Impact of home confinement during the COVID‐19 pandemic on medication use and disease activity in spondyloarthritis patients date: 2020-06-17 words: 788.0 sentences: 57.0 pages: flesch: 46.0 cache: ./cache/cord-280984-2j8ckz14.txt txt: ./txt/cord-280984-2j8ckz14.txt summary: title: Impact of home confinement during the COVID‐19 pandemic on medication use and disease activity in spondyloarthritis patients Home confinement, imposed as part of the social distancing measures in the fight against the coronavirus disease 2019 (COVID‐19), poses several problems for patients with spondyloarthritis (SpA), including the lack of physical activity, psychological factors, and the confusion related to the prescriptions of NSAIDs. We investigated the impact of confinement on the medication intake and disease activity in SpA patients in a questionnaire‐based survey. We investigated the impact of confinement on the medication intake and disease activity in SpA patients in a questionnaire-based survey. However, this is the first study providing information on therapy compliance during home confinement and the frequency of COVID-19 in SpA patients. Thus, this survey shows that home confinement linked to the COVID-19 pandemic is associated with worsening of the disease and a reduction or suspension of medication intake, in particular NSAIDs, in SpA patients. abstract: Home confinement, imposed as part of the social distancing measures in the fight against the coronavirus disease 2019 (COVID‐19), poses several problems for patients with spondyloarthritis (SpA), including the lack of physical activity, psychological factors, and the confusion related to the prescriptions of NSAIDs. We investigated the impact of confinement on the medication intake and disease activity in SpA patients in a questionnaire‐based survey. url: https://www.ncbi.nlm.nih.gov/pubmed/32779880/ doi: 10.1002/art.41397 id: cord-338666-gg9qcpmz author: Rubin, Geoffrey A. title: Restructuring Electrophysiology During the COVID-19 Pandemic: A Practical Guide From a New York City Hospital Network date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 crisis is a global pandemic of a novel infectious disease with far-ranging public health implications. With regard to cardiac electrophysiology (EP) services, we discuss the “real-world” challenges and solutions that have been essential for efficient and successful (1) ramping down of standard clinical practice patterns and (2) pivoting of workflow processes to meet the demands of this pandemic. The aims of these recommendations are to outline: (1) essential practical steps to approaching procedures, as well as outpatient and inpatient care of EP patients, with relevant examples, (2) successful strategies to minimize exposure risk to patients and clinical staff while also balancing resource utilization, (3) challenges related to redeployment and restructuring of clinical and support staff, and (4) considerations regarding continued collaboration with clinical and administrative colleagues to implement these changes. While process changes will vary across practices and hospital systems, we believe that these experiences from 4 different EP sections in a large New York City hospital network currently based in the global epicenter of the coronavirus disease 2019 pandemic will prove useful for other EP practices adapting their own practices in preparation for local surges. url: https://doi.org/10.1097/hpc.0000000000000225 doi: 10.1097/hpc.0000000000000225 id: cord-303483-wendrxee author: Rubin, Geoffrey D. title: The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society date: 2020-04-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: With more than 900,000 confirmed cases worldwide and nearly 50,000 deaths during the first three months of 2020, the COVID-19 pandemic has emerged as an unprecedented healthcare crisis. The spread of COVID-19 has been heterogeneous, resulting in some regions having sporadic transmission and relatively few hospitalized patients with COVID-19 and others having community transmission that has led to overwhelming numbers of severe cases. For these regions, healthcare delivery has been disrupted and compromised by critical resource constraints in diagnostic testing, hospital beds, ventilators, and healthcare workers who have fallen ill to the virus exacerbated by shortages of personal protective equipment. While mild cases mimic common upper respiratory viral infections, respiratory dysfunction becomes the principal source of morbidity and mortality as the disease advances. Thoracic imaging with chest radiography (CXR) and computed tomography (CT) are key tools for pulmonary disease diagnosis and management, but their role in the management of COVID-19 has not been considered within the multivariable context of the severity of respiratory disease, pre-test probability, risk factors for disease progression, and critical resource constraints. To address this deficit, a multidisciplinary panel comprised principally of radiologists and pulmonologists from 10 countries with experience managing COVID-19 patients across a spectrum of healthcare environments evaluated the utility of imaging within three scenarios representing varying risk factors, community conditions, and resource constraints. Fourteen key questions, corresponding to 11 decision points within the three scenarios and three additional clinical situations, were rated by the panel based upon the anticipated value of the information that thoracic imaging would be expected to provide. The results were aggregated, resulting in five main and three additional recommendations intended to guide medical practitioners in the use of CXR and CT in the management of COVID-19. url: https://doi.org/10.1148/radiol.2020201365 doi: 10.1148/radiol.2020201365 id: cord-277803-7p1qu2rf author: Rubino, Francesco title: Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery date: 2020-05-07 words: 6087.0 sentences: 284.0 pages: flesch: 35.0 cache: ./cache/cord-277803-7p1qu2rf.txt txt: ./txt/cord-277803-7p1qu2rf.txt summary: Given the uncertainty regarding the effects and duration of the COVID-19 outbreak, combined with the progressive nature of obesity, diabetes, and related conditions, delaying bariatric and metabolic surgery could increase the risks for morbidity and mortality in surgical candidates. abstract: The coronavirus disease 2019 pandemic is wreaking havoc on society, especially health-care systems, including disrupting bariatric and metabolic surgery. The current limitations on accessibility to non-urgent care undermine postoperative monitoring of patients who have undergone such operations. Furthermore, like most elective surgery, new bariatric and metabolic procedures are being postponed worldwide during the pandemic. When the outbreak abates, a backlog of people seeking these operations will exist. Hence, surgical candidates face prolonged delays of beneficial treatment. Because of the progressive nature of obesity and diabetes, delaying surgery increases risks for morbidity and mortality, thus requiring strategies to mitigate harm. The risk of harm, however, varies among patients, depending on the type and severity of their comorbidities. A triaging strategy is therefore needed. The traditional weight-centric patient-selection criteria do not favour cases based on actual clinical needs. In this Personal View, experts from the Diabetes Surgery Summit consensus conference series provide guidance for the management of patients while surgery is delayed and for postoperative surveillance. We also offer a strategy to prioritise bariatric and metabolic surgery candidates on the basis of the diseases that are most likely to be ameliorated postoperatively. Although our system will be particularly germane in the immediate future, it also provides a framework for long-term clinically meaningful prioritisation. url: https://www.sciencedirect.com/science/article/pii/S2213858720301571 doi: 10.1016/s2213-8587(20)30157-1 id: cord-311044-kjx0z1hc author: Rubio-Pérez, Inés title: COVID-19: key concepts for the surgeon date: 2020-05-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract In view of the current pandemic by SARS-CoV-2 it deems essential to understand the key concepts about the infection: its epidemiological origin, presentation, clinical course, diagnosis and treatment (still experimental in many cases). The knowledge about the virus is still limited, but as the pandemic progresses and the physiopathology of the disease is understood, new evidence is being massively published. Surgical specialists are facing an unprecedented situation: they must collaborate in the ER or medical wards attending these patients, while still needing to make decisions about surgical patients with probable COVID-19. The present narrative review aims to summarize the most relevant aspects and synthetize concepts on COVID-19 for surgeons. url: https://api.elsevier.com/content/article/pii/S2173507720301101 doi: 10.1016/j.cireng.2020.05.009 id: cord-333876-fhxkpbq7 author: Rucker, Janet C. title: Cerebellum—Editorial Regarding Consensus Paper Consensus on Virtual Management of Vestibular Disorders: Urgent Versus Expedited Care. Shaikh et al., doi.org/10.1007/s12311-020—01178-8: The Return of the House Call: Evaluating Acutely Ill Patients with Vertigo in the Era of Virtual Health Care date: 2020-09-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s12311-020-01184-w doi: 10.1007/s12311-020-01184-w id: cord-331762-b0yufidn author: Rudski, Lawrence title: Multimodality Imaging in Evaluation of Cardiovascular complications in Patients with COVID-19 date: 2020-07-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Standard evaluation and management of the patient with suspected or proven cardiovascular complications of COVID-19, the disease caused by severe acute respiratory syndrome–related coronavirus-2 (SARS-CoV-2), is challenging. Routine history, physical examination, laboratory testing, electrocardiography and plain x-ray imaging may often suffice for such patients but given overlap between COVID-19 and typical cardiovascular diagnoses such as heart failure and acute myocardial infarction, need frequently arises for advanced imaging techniques to assist in differential diagnosis and management. This document provides guidance in several common scenarios among patients with confirmed or suspected COVID-19 infection and possible cardiovascular involvement, including chest discomfort with electrocardiographic changes, acute hemodynamic instability, newly-recognized left ventricular dysfunction, as well as imaging during the sub-acute/chronic phase of COVID-19. For each, we consider the role of biomarker testing to guide imaging decision-making, provide differential diagnostic considerations, and offer general suggestions regarding application of various advanced imaging techniques. Condensed Abstract Standard evaluation and management of the patient with suspected or proven cardiovascular complications due to COVID-19 infection often requires advanced imaging techniques to assist in differential diagnosis and management. This document provides guidance in several common scenarios among patients with COVID-19 infection and for each provides advice regarding the role of biomarker testing to guide imaging decision-making, provides differential diagnostic considerations, and offers general suggestions regarding application of various advanced imaging techniques. url: https://www.ncbi.nlm.nih.gov/pubmed/32710927/ doi: 10.1016/j.jacc.2020.06.080 id: cord-018620-3kqx8arn author: Rueda, Mario title: Hepatic Failure date: 2016-10-09 words: 13808.0 sentences: 842.0 pages: flesch: 44.0 cache: ./cache/cord-018620-3kqx8arn.txt txt: ./txt/cord-018620-3kqx8arn.txt summary: In this chapter we will discuss the definition, clinical manifestations, workup, and management of acute and chronic liver failure and the general principles of treatment of these patients. Other mechanisms that may explain this symptom include the endogenous opioids theory which proposes that the liver failure patient has elevated opioid levels secondary to decrease clearance and metabolism. Past medical history plays a key role in determining if the patient has chronic liver disease or if they are experiencing an acute failure. A decrease in glutathione levels, enhanced cytochrome P450 activity secondary to medication use, acetaminophen overdose, or decreased liver function from chronic disease make patients more susceptible to developing toxicity. Patients with hepatitis secondary to shock present with several symptoms related to their hemodynamic instability including altered mental status, respiratory distress, severe hypotension, and renal failure. abstract: The progression of liver disease can cause several physiologic derangements that may precipitate hepatic failure and require admission to an intensive care unit. The underlying pathology may be acute, acute-on chronic, or chronic in nature. Liver failure may manifest with a variety of clinical signs and symptoms that need prompt attention. The compromised synthetic and metabolic activity of the failing liver affects all organ systems, from neurologic to integumentary. Supportive care and specific therapies should be instituted in order to improve outcome and minimize time of recovery. In this chapter we will discuss the definition, clinical manifestations, workup, and management of acute and chronic liver failure and the general principles of treatment of these patients. Management of liver failure secondary to certain common etiologies will also be presented. Finally, liver transplantation and alternative therapies will also be discussed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123541/ doi: 10.1007/978-3-319-33341-0_18 id: cord-270245-zziwb2jy author: Russell, Beth title: Factors Affecting COVID-19 Outcomes in Cancer Patients: A First Report From Guy''s Cancer Center in London date: 2020-07-22 words: 4112.0 sentences: 192.0 pages: flesch: 47.0 cache: ./cache/cord-270245-zziwb2jy.txt txt: ./txt/cord-270245-zziwb2jy.txt summary: Being of Asian ethnicity [3.73 (1.28–10.91)], receiving palliative treatment [5.74 (1.15–28.79)], having an initial cancer diagnosis >24 months before [2.14 (1.04–4.44)], dyspnea [4.94 (1.99–12.25)], and increased CRP levels [10.35 (1.05–52.21)] were positively associated with COVID-19 death. During a median follow-up of 37 days, the following cancer patient characteristics were found to be positively associated with COVID-19 death: Asian ethnicity, palliative treatment, initial cancer diagnosis >24 months, dyspnea at presentation, and high CRP levels. Apart from the CCC-19 Consortium (16) , no study to date has specifically looked at COVID-19 severity at presentation in COVID-19 positive cancer patients and hence our observation of an association with time since cancer diagnosis and presenting symptoms needs further validation in other large cohorts with homogenous definitions of inclusion criteria, testing strategies, and outcome measures. abstract: Background: There is insufficient evidence to support clinical decision-making for cancer patients diagnosed with COVID-19 due to the lack of large studies. Methods: We used data from a single large UK Cancer Center to assess the demographic/clinical characteristics of 156 cancer patients with a confirmed COVID-19 diagnosis between 29 February and 12 May 2020. Logistic/Cox proportional hazards models were used to identify which demographic and/or clinical characteristics were associated with COVID-19 severity/death. Results: 128 (82%) presented with mild/moderate COVID-19 and 28 (18%) with a severe case of the disease. An initial cancer diagnosis >24 months before COVID-19 [OR: 1.74 (95% CI: 0.71–4.26)], presenting with fever [6.21 (1.76–21.99)], dyspnea [2.60 (1.00–6.76)], gastro-intestinal symptoms [7.38 (2.71–20.16)], or higher levels of C-reactive protein [9.43 (0.73–121.12)] were linked with greater COVID-19 severity. During a median follow-up of 37 days, 34 patients had died of COVID-19 (22%). Being of Asian ethnicity [3.73 (1.28–10.91)], receiving palliative treatment [5.74 (1.15–28.79)], having an initial cancer diagnosis >24 months before [2.14 (1.04–4.44)], dyspnea [4.94 (1.99–12.25)], and increased CRP levels [10.35 (1.05–52.21)] were positively associated with COVID-19 death. An inverse association was observed with increased levels of albumin [0.04 (0.01–0.04)]. Conclusions: A longer-established diagnosis of cancer was associated with increased severity of infection as well as COVID-19 death, possibly reflecting the effects a more advanced malignant disease has on this infection. Asian ethnicity and palliative treatment were also associated with COVID-19 death in cancer patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32903324/ doi: 10.3389/fonc.2020.01279 id: cord-283165-mdkr9qo0 author: Russell, C.D. title: Diagnosis and features of hospital-acquired pneumonia: a retrospective cohort study date: 2015-12-15 words: 3885.0 sentences: 202.0 pages: flesch: 36.0 cache: ./cache/cord-283165-mdkr9qo0.txt txt: ./txt/cord-283165-mdkr9qo0.txt summary: The aim of this study was to retrospectively evaluate the accuracy of the diagnosis of HAP in inpatients on acute internal medicine and general surgical wards receiving intravenous antimicrobials for a clinical diagnosis of HAP made by the patient''s team. This was a retrospective observational cohort study of medical and surgical inpatients receiving intravenous antimicrobials for a clinical diagnosis of HAP at a tertiary care hospital in Edinburgh, UK. To be classified as radiologically confirmed HAP in this study, chest X-ray evidence of a new or progressive lung infiltrate was required (reported by a radiologist), consistent with the 2005 ATS/IDSA guidelines. In comparison to community-acquired pneumonia, where the culture-positive rate of sputum samples at our institution has been reported as 30%, a bacterial pathogen was identified from 17 of 35 (48.6%) samples from patients with radiologically confirmed HAP and therefore has greater potential to influence management. abstract: BACKGROUND: Hospital-acquired pneumonia (HAP) is defined as radiologically confirmed pneumonia occurring ≥48 h after hospitalization, in non-intubated patients. Empirical treatment regimens use broad-spectrum antimicrobials. AIM: To evaluate the accuracy of the diagnosis of HAP and to describe the demographic and microbiological features of patients with HAP. METHODS: Medical and surgical inpatients receiving intravenous antimicrobials for a clinical diagnosis of HAP at a UK tertiary care hospital between April 2013 and 2014 were identified. Demographic and clinical details were recorded. FINDINGS: A total of 166 adult patients with a clinical diagnosis of HAP were identified. Broad-spectrum antimicrobials were prescribed, primarily piperacillin–tazobactam (57.2%) and co-amoxiclav (12.5%). Sputum from 24.7% of patients was obtained for culture. Sixty-five percent of patients had radiological evidence of new/progressive infiltrate at the time of HAP treatment, therefore meeting HAP diagnostic criteria (2005 American Thoracic Society/Infectious Diseases Society of America guidelines). Radiologically confirmed HAP was associated with higher levels of inflammatory markers and sputum culture positivity. Previous surgery and/or endotracheal intubation were associated with radiologically confirmed HAP. A bacterial pathogen was identified from 17/35 sputum samples from radiologically confirmed HAP patients. These were Gram-negative bacilli (N = 11) or Staphylococcus aureus (N = 6). Gram-negative bacteria tended to be resistant to co-amoxiclav, but susceptible to ciprofloxacin, piperacillin–tazobactam and meropenem. Five of the six S. aureus isolates were meticillin susceptible and all were susceptible to doxycycline. CONCLUSION: In ward-level hospital practice ‘HAP’ is an over-used diagnosis that may be inaccurate in 35% of cases when objective radiological criteria are applied. Radiologically confirmed HAP represents a distinct clinical and microbiological phenotype. Potential risk factors were identified that could represent targets for preventive interventions. url: https://api.elsevier.com/content/article/pii/S0195670115004934 doi: 10.1016/j.jhin.2015.11.013 id: cord-315181-emf4i6ir author: Ryoo, Nayoung title: Coping with Dementia in the Middle of the COVID-19 Pandemic date: 2020-10-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Multiple neurological complications have been associated with the coronavirus disease-19 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. This is a narrative review to gather information on all aspects of COVID-19 in elderly patients with cognitive impairment. First, the following three mechanisms have been proposed to underlie the neurological complications associated with COVID-19: 1) direct invasion, 2) immune and inflammatory reaction, and 3) hypoxic brain damage by COVID-19. Next, because the elderly dementia patient population is particularly vulnerable to COVID-19, we discussed risk factors and difficulties associated with cognitive disorders in this vulnerable population. We also reviewed the effects of the patient living environment in COVID-19 cases that required intensive care unit (ICU) care. Furthermore, we analyzed the impact of stringent social restrictions and COVID-19 pandemic-mediated policies on dementia patients and care providers. Finally, we provided the following strategies for working with elderly dementia patients: general preventive methods; dementia care at home and nursing facilities according to the activities of daily living and dementia characteristics; ICU care after COVID-19 infection; and public health care system and government response. We propose that longitudinal follow-up studies are needed to fully examine COVID-19 associated neurological complications, such as dementia, and the efficacy of telemedicine/telehealth care programs. url: https://www.ncbi.nlm.nih.gov/pubmed/33140593/ doi: 10.3346/jkms.2020.35.e383 id: cord-297840-z5l6vdsr author: Río, Francisco García title: Air Travel and Respiratory Disease date: 2007-02-28 words: 16164.0 sentences: 949.0 pages: flesch: 54.0 cache: ./cache/cord-297840-z5l6vdsr.txt txt: ./txt/cord-297840-z5l6vdsr.txt summary: 57 In any case, to establish a medical opinion on risk in air travel, the type, reversibility, and degree of functional impairment caused by the disease must be assessed along with the tolerance of the patient for the predicted flight altitude and the length of exposure. Supplementary oxygen is recommended during air travel for patients who have an estimated in-flight PaO 2 of less then 50 mm Hg obtained with prediction equations or, preferably, a hypoxic challenge test ( Figure 6 ). It also seems wise to extend that treatment option to those cases and in which the in-flight cabin pressure corresponds to an altitude of greater than 2438 m (8000 feet) and the patient has very severe COPD (FEV 1 ≤30%), where limitations may be present in the mechanisms of compensation for hypoxemia, or diseases that alter oxygen transport. abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1579212907600317 doi: 10.1016/s1579-2129(07)60031-7 id: cord-260503-yq4dtf8n author: SAMARANAYAKE, LAKSHMAN P. title: Severe acute respiratory syndrome and dentistry A retrospective view date: 2004-09-30 words: 6836.0 sentences: 383.0 pages: flesch: 54.0 cache: ./cache/cord-260503-yq4dtf8n.txt txt: ./txt/cord-260503-yq4dtf8n.txt summary: Objectives The authors trace the emergence of the SARS outbreak from southern China and its spread worldwide, discuss the viral etiology of the infection and its clinical features, and review the infection control guidelines issued during the outbreak by the health authorities in Hong Kong, the Centers for Disease Control and Prevention, the World Health Organization and the American Dental Association. Conclusions and Clinical Implications Researchers believe that a combination of factors, including the universal infection control measures that the dental community has implemented and/or the low degree of viral shedding in the prodromal phase of SARS, may have obviated the spread of the disease in dental settings. Interim domestic infection control precautions for aerosol-generating procedures on C L I N I C A L P R A C T I C E patients with severe acute respiratory syndrome (SARS) abstract: ABSTRACT Background Severe acute respiratory syndrome, or SARS, which has created panic in Asia and in some parts of North America, is the first epidemic of the new century. Although it has been well-contained, sporadic cases continue to emerge. Objectives The authors trace the emergence of the SARS outbreak from southern China and its spread worldwide, discuss the viral etiology of the infection and its clinical features, and review the infection control guidelines issued during the outbreak by the health authorities in Hong Kong, the Centers for Disease Control and Prevention, the World Health Organization and the American Dental Association. They also review the prospects for a new outbreak and preventive measures. Overview The disease, which is caused by a novel coronavirus termed the “SARS coronavirus,” or SARS-CoV, essentially spreads through droplet infection and affects people of any age. It has a mortality rate ranging from 10 to 15 percent. A major hallmark of this disease has been the rate at which it has affected health care workers through nosocomial transmission; in some countries, up to one-fourth to one-third of those infected were in this category. However, no dental health care worker has been affected by SARS in a nosocomial or dental setting. Conclusions and Clinical Implications Researchers believe that a combination of factors, including the universal infection control measures that the dental community has implemented and/or the low degree of viral shedding in the prodromal phase of SARS, may have obviated the spread of the disease in dental settings. The dental community should reflect on this outbreak to reinforce the currently applied infection control measures. url: https://www.ncbi.nlm.nih.gov/pubmed/15493394/ doi: 10.14219/jada.archive.2004.0405 id: cord-296494-6kn4mr04 author: Saban-Ruiz, J. title: COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs. The Role of Aging Beyond Topics date: 2020-05-12 words: 6444.0 sentences: 326.0 pages: flesch: 50.0 cache: ./cache/cord-296494-6kn4mr04.txt txt: ./txt/cord-296494-6kn4mr04.txt summary: Bearing this in mind, it is quite likely, that if we have fewer complications, particularly severe ones (cardiac arrest, ventricular tachyarrhythmia, acute heart failure, acute coronary syndrome, haemorrhagic or massive ischaemic stroke), this integrated approach could cut down the elevated mortality in the highest risk group (cancer, COPD and oldest subjects with comorbidities), usually preceded by a multi-organ failure. In aged COVID-19 patients or with history of coronary artery disease (CAD) an acute coronary syndrome (ACS) can also be seen for plaque vulnerability in the presence of a pro-inflammatory state with cytokine release (71) but from the experience in animals, could it be plausible that any of them could be due to arteritis? The third aspect would be the combination of T2DM and Heart failure (HF) (the most frequent cardiac complication in any of the phases of the disease), which is present in a high percentage of patients, especially those at higher risk. abstract: COVID 19 is much more than an infectious disease by SARS-CoV-2 followed by a disproportionate immune response. An older age, diabetes and history of cardiovascular disease, especially hypertension, but also chronic heart failure and coronary artery disease among others, are between the most important risk factors. In addition, during the hospitalization both hyperglycaemia and heart failure are frequent. Less frequent are acute coronary syndrome, arrhythmias and stroke. Accordingly, not all prolonged stays or even deaths are due directly to SARS-CoV-2. To our knowledge, this is the first review, focusing both on cardiovascular and metabolic aspects of this dreadful disease, in an integrated and personalized way, following the guidelines of the Cardiometabolic Health/Medicine. Therefore, current personalized aspects such as ACEIs and ARBs, the place of statins and the most appropriate management of heart failure in diabetics are analysed. Aging, better than old age, as a dynamic process, is also considered in this review for the first time in the literature, and not only as a risk factor attributed to cardiovascular and non-cardiovascular comorbidities. Immunosenescence is also approached to build healthier elders, so they can resist present and future infectious diseases, and not only in epidemics or pandemics. In addition, to do this we must start knowing the molecular mechanisms that underlying Aging process in general, and immunosenescence in particular. Surprisingly, the endoplasmic reticulum stress and autophagy are implicated in both process. Finally, with a training in all the aspects covered in this review, not only the hospital stay, complications and costs of this frightening disease in high-risk population should be reduced. Likely, this paper will open a gate to the future for open-minded physicians. url: https://doi.org/10.1007/s12603-020-1385-5 doi: 10.1007/s12603-020-1385-5 id: cord-261485-0ke5nqy0 author: Sabir, A. M. title: Effects of Anticoagulants and Corticosteroids therapy in patients affected by severe COVID-19 Pneumonia date: 2020-06-29 words: 4666.0 sentences: 303.0 pages: flesch: 54.0 cache: ./cache/cord-261485-0ke5nqy0.txt txt: ./txt/cord-261485-0ke5nqy0.txt summary: Severe COVID-19 pneumonia group were 63 patients who received methylprednisolone, enoxaparin, antiviral drugs, empirical antibiotics for pneumonia, and standard treatment for comorbidity. Conclusion Early use of a combined anti-inflammatory (corticosteroids and Enoxaparin) and antiviral drugs treatment in patients with moderate to severe COVID-19 pneumonia prevent complications of the disease and improve clinical outcomes. This study evaluates the effectiveness of a combination treatment of anti-inflammatory (corticosteroids and Enoxaparin) and antiviral drugs to treat severe COVID-19 pneumonia. There is one patient in medical ward needs low flow oxygen therapy and methylprednisolone for more than 21 days due to unknown reason or confirmed significant lung disease or infection, but Bactrim was given empirically for possible pneumocystis pneumonia, then improved and discharged home. Extra days of length of stay, and virus clearance time, higher oxygen therapy among patients with comorbidity and moderate COVID-19 pneumonia. abstract: Background In the absence of a standard of treatment for COVID-19, the combined use of anti-inflammatory (corticosteroids and Enoxaparin) and antiviral drugs may be more effective than using either modality alone in the treatment of COVID-19. Methods Patients hospitalized between April 10th, 2020, through May 10th, 2020, who had confirmed COVID-19 infection with clinical or radiographic evidence of pneumonia, in which 65 patients have moderate COVID-19 pneumonia, and 63 patients have severe COVID-19 pneumonia. All patients received early combination therapy of anti-inflammatory (corticosteroids and Enoxaparin) and antiviral drugs. They assessed for type and duration of treatment, and days need to wean from oxygen therapy, length of stay, virus clearance time, and complication or adverse events. All patients had more than 28 days follow up after discharge from the hospital. Results Moderate COVID-19 pneumonia group were 65 patients who received Enoxaparin, antiviral drugs, empirical antibiotics for pneumonia, and standard treatment for comorbidity. Male patients were 50 (76.9 %) and female patients were 15 (23.1 %). 34 (52.3 %) patients have comorbidity, 25 (38.5%) patients have Diabetes Mellitus and 2 (3.1 %) pregnant ladies. 19 (29.2 %) patients were on low flow oxygen therapy, 3L oxygen or less to maintain oxygen saturation more than 92%. All patients discharged home with no major or minor bleeding complications or significant complications. Severe COVID-19 pneumonia group were 63 patients who received methylprednisolone, enoxaparin, antiviral drugs, empirical antibiotics for pneumonia, and standard treatment for comorbidity. Male patients were 55 (87.3 %) and female patients were 8 (12.7 %). 37 (58.7 %) patients have comorbidity, and 24 (38.1%) patients have Diabetes Mellitus. 32 (50.8 %) patients were on low flow oxygen therapy, 4-9L oxygen, and 31 (49.2 %) patients were on low flow oxygen therapy, 10L oxygen or more, including 12 patients on a non-rebreathing mask. Patients received methylprednisolone were 37 (58.7 %) for 3 days, 16 (25.4 %) for 5 days and 10 (15.9 %) for more than 5 days. Sixty-two patients discharged home with one patient had a long stay, and the other two transferred to ICU. One long-stay patient transferred to ICU on low flow oxygen therapy. Conclusion Early use of a combined anti-inflammatory (corticosteroids and Enoxaparin) and antiviral drugs treatment in patients with moderate to severe COVID-19 pneumonia prevent complications of the disease and improve clinical outcomes. url: http://medrxiv.org/cgi/content/short/2020.06.22.20134957v1?rss=1 doi: 10.1101/2020.06.22.20134957 id: cord-309507-oe4i6v5x author: Sacchelli, L. title: Sexually Transmitted Infections during the COVID‐19 outbreak: comparison of patients referring to the service of sexually transmitted diseases during the sanitary emergency with those referring during the common practice date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Sexually transmitted infections (STIs) and diseases (STDs) affect millions of people every year worldwide(1). In Italy, data are provided by the Italian National Institute of Health (INIH) and reported to the European Centre for Disease Prevention and Control (ECDC)(2,3). In 1991 and 2009 the Italian sentinel surveillance system was established, consisting in 25 public centers (12 clinical, 13 laboratories) on the national field for diagnosis, treatment and data transmission to the INIH(4). The STDs service of Dermatology, Bologna belongs to it and is a free‐access service (7.30‐11 am) from Monday to Friday, with a patient flow of 50 patients/day. url: https://www.ncbi.nlm.nih.gov/pubmed/32491214/ doi: 10.1111/jdv.16694 id: cord-006701-q8qh1kas author: Sadeghi, Behnam title: Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells date: 2019-12-18 words: 2343.0 sentences: 159.0 pages: flesch: 56.0 cache: ./cache/cord-006701-q8qh1kas.txt txt: ./txt/cord-006701-q8qh1kas.txt summary: We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. The second patient was a 34-year old woman who was admitted 8 months after allogeneic hematopoietic stem cell transplantation due to hemolysis, impaired sensorium below arcus, and difficulty in ambulation. We have used placenta-derived decidua stromal cells (DSCs) for acute and chronic GVHD, ARDS and hemorrhagic cystitis [8] [9] [10] [11] . Electrophysiological investigation following DSCs infusion showed some improvement with more frequent motor unit activity, especially in the right arm. The day after the DSC infusion, she had normal sensation on neurological examination and subjectively in the lower abdomen and legs. The patient was examined with TMS and SEPs every 3-5 months up to a year after the onset of neurological symptoms. Placenta-derived decidua stromal cells for treatment of severe acute graft-versus-host disease abstract: Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patients with radiculomyelopathy. The first patient was a 73-year old man treated with parotidectomy and irradiation for lymphoma of the neck. Following a Yersinia infection, he developed a radiculomyelopathy in C3/C4 and could not elevate his arms. The second patient was a 34-year old woman who was admitted 8 months after allogeneic hematopoietic stem cell transplantation due to hemolysis, impaired sensorium below arcus, and difficulty in ambulation. Following intravenous infusion of DSCs (1 × 10(6)/kg/infusion), the first patient could elevate his arms to the facial level. He experienced recurrent paralysis after 6 months, and the efficacy of four additional DSC infusions, at subsequent occasions, were limited and transient. The second patient was treated with two doses of DSCs (1 × 10(6)/kg/infusion). After cell infusion, she was able to stand on one leg, sensation in the belly normalized, and she was discharged. These two cases suggest that DSCs may be useful in the treatment of neuroinflammatory disorders. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102257/ doi: 10.1007/s12185-019-02804-w id: cord-266456-10tjzqep author: Sadeghipour, Parham title: Management of ST‐segment‐elevation myocardial infarction during the coronavirus disease 2019 (COVID‐19) outbreak: Iranian“247” National Committee''s position paper on primary percutaneous coronary intervention date: 2020-04-22 words: 1438.0 sentences: 102.0 pages: flesch: 47.0 cache: ./cache/cord-266456-10tjzqep.txt txt: ./txt/cord-266456-10tjzqep.txt summary: title: Management of ST‐segment‐elevation myocardial infarction during the coronavirus disease 2019 (COVID‐19) outbreak: Iranian"247" National Committee''s position paper on primary percutaneous coronary intervention Such safety concerns, along with the acceptable mortality benefit of the new generation of fibrinolytic agents, have placed thrombolytic therapy as a potential first choice on several occasions during the outbreak. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction (ASSENT-4 PCI): randomised trial Impact of coronavirus disease 2019 (COVID-19) outbreak on ST-segment-elevation myocardial infarction care in Hong Kong The management of antiplatelet therapy in acute coronary syndrome patients with thrombocytopenia: a clinical conundrum Management of ST-segment-elevation myocardial infarction during the coronavirus disease 2019 (COVID-19) outbreak: Iranian"247" National Committee''s position paper on primary percutaneous coronary intervention abstract: World Health Organization has designated coronavirus disease 2019 (COVID‐19) as a pandemic. During the past several weeks, a considerable burden has been imposed on the Iranian's healthcare system. The present document reviewed the latest evidence and expert opinion regarding the management of ST‐segment‐elevation myocardial infarction during the outbreak of COVID‐19 and outlines a practical algorithm for it. url: https://www.ncbi.nlm.nih.gov/pubmed/32320138/ doi: 10.1002/ccd.28889 id: cord-263691-ovsi38bx author: Sadler, Diego title: Practical and cost-effective model to build and sustain a cardio-oncology program date: 2020-07-16 words: 5457.0 sentences: 265.0 pages: flesch: 38.0 cache: ./cache/cord-263691-ovsi38bx.txt txt: ./txt/cord-263691-ovsi38bx.txt summary: This study describes how to establish a successful cardio-oncology program, with limited resources, in order to effectively manage the unique care required by this patient population. There are multiple factors that may lead to decreased healthcare access and poor clinical outcomes for many of these patients, including: the lack of knowledge regarding the association between cancer and heart disease, lack of early detection of potentially cardio-toxic effects of certain cancer-related treatments, the prevalence of an aging population amongst cancer survivors [5] . We defined the success of our program by the ability to start and maintain a new service line in our institution, meeting the needs of a growing patient population, our strong cooperation with the oncology department, the achieved goal of bringing awareness of cardiovascular health in cancer patients, and by specific clinical benefits to multiple patients as described herein. abstract: BACKGROUND: Cardio-Oncology (CO) is a new subspecialty that thrives mostly in large academic quaternary centers. This study describes how to establish a successful cardio-oncology program, with limited resources, in order to effectively manage the unique care required by this patient population. METHODS: Clinical data was collected from 25 consecutive months. There were four foundational elements to establish a CO program: 1. Clinical program: integrating staff and resources from the Heart and Vascular, and Cancer Centers; 2. Education Program: establishing a platform to educate/advocate with respect to CO; 3. Engagement with professional societies: active engagement allowed for the successful establishment of the proposed CO program; and 4. Research program: establishing data collection modalities/cooperation with other institutions. RESULTS: 474 consecutive patients were treated by our CO program during the first 25 months of operation. Clinical data, information about cancer treatment, cardiovascular co morbidities, cardiac testing and impact of CO management are reported. CONCLUSIONS: A successful CO program can be established utilizing existing resources without the need for significant additional assets. Integration with professional societies, advocacy, education and research, provide a platform for learning and growth. This model improves access to care and can be reproduced in a variety of settings. url: https://doi.org/10.1186/s40959-020-00063-x doi: 10.1186/s40959-020-00063-x id: cord-273641-8l57mnjt author: Sadr, Sara title: Isolated severe thrombocytopenia in a patient with COVID-19: A case report date: 2020-05-29 words: 1438.0 sentences: 79.0 pages: flesch: 46.0 cache: ./cache/cord-273641-8l57mnjt.txt txt: ./txt/cord-273641-8l57mnjt.txt summary: A narrow diagnostic approach where only febrile patients with pulmonary symptoms are evaluated for a COVID-19 diagnosis will result in many missed diagnoses; so it is important that physicians are familiar with atypical and rare presentations of COVID-19, such as isolated thrombocytopenia. The emerging disease caused by a novel coronavirus with a high transmission rate, predominantly pulmonary symptoms and a reported mortality rate ranging between 2.0-4.4% has become a global pandemic [1, 7, 8] , and the infection can cause systemic involvement including respiratory, neurological and hematopoietic complications [3, 4] . In another study which observed the hematologic impacts of COVID-19, 20 % of patients showed abnormalities that included mild thrombocytopenia as severe as it has been reported in other viral infections such as dengue fever [14] . Severe thrombocytopenia has been reported in one case of COVID-19 that was associated with pulmonary symptoms as well as neurological complications [15] . abstract: COVID-19 is known to cause serious respiratory symptoms and involvement of other body systems such as hematopoietic, neurological and the immune system. In this report, we described a case of a COVID-19 patient who presented with no pulmonary involvement but severe thrombocytopenia. She suffered from headache and malaise with no respiratory symptoms, fever or chills. Chest radiological imaging was unremarkable but, the laboratory results showed significant thrombocytopenia associated with relatively decreased lymphocytes. Based on her high-risk work environment, a reverse transcription polymerase chain reaction (RT-PCR) test was performed and SARS-CoV-2 RNA was detected in the nasopharyngeal swab. Complete blood count (CBC) of patient was re-checked during admission and platelet count showed rising trend up to normal levels. A narrow diagnostic approach where only febrile patients with pulmonary symptoms are evaluated for a COVID-19 diagnosis will result in many missed diagnoses; so it is important that physicians are familiar with atypical and rare presentations of COVID-19, such as isolated thrombocytopenia. url: https://www.ncbi.nlm.nih.gov/pubmed/32483524/ doi: 10.1016/j.idcr.2020.e00820 id: cord-104507-xx7t26rl author: Safari, Saeid title: Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Severe COVID-19 patients; a Narrative Review date: 2020-08-22 words: 3425.0 sentences: 173.0 pages: flesch: 31.0 cache: ./cache/cord-104507-xx7t26rl.txt txt: ./txt/cord-104507-xx7t26rl.txt summary: Based on previous experience of blood purification to treat cytokine storm syndrome (CSS) in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), here we aimed to review the current literature on extracorporeal hemoperfusion as a potential therapeutic option for CSS-associated conditions, with a focus on severe COVID-19. To date, various centers in different countries including Italy, China, USA, Germany, and Iran have reported or are investigating the beneficial effects of different hemoperfusion systems, including HA380/HA330 cartridges, CytoSorb, and polymyxin B immobilized fiber column in treatment of critically-ill COVID-19 patients. To date, a large number of experimental and clinical data, mostly from case reports and case series, have introduced CytoSorb as an effective rescue therapy for removal of inflammatory cytokines and achievement of hemodynamic stabilization in critically ill patients with septic shock and kidney failure (47) (48) (49) . abstract: The 2019 novel coronavirus (officially known as severe acute respiratory syndrome coronavirus 2, SARS-CoV2) was first found in Wuhan, China. On February 11, 2020, the World Health Organization (WHO) has declared the outbreak of the disease caused by SARS-CoV2, named coronavirus disease 2019 (COVID-19), as an emergency of international concern. Based on the current epidemiological surveys, some COVID-19 patients with severe infection gradually develop impairment of the respiratory system, acute kidney injury (AKI), multiple organ failure, and ultimately, death. Currently, there is no established pharmacotherapy available for COVID-19. As seen in influenza, immune damage mediated by excessive production of inflammatory mediators contributes to high incidence of complications and poor prognosis. Thus, removal or blocking the overproduction of these mediators potentially aids in reducing the deleterious cytokine storm and improving critically ill patients’ outcomes. Based on previous experience of blood purification to treat cytokine storm syndrome (CSS) in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), here we aimed to review the current literature on extracorporeal hemoperfusion as a potential therapeutic option for CSS-associated conditions, with a focus on severe COVID-19. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587998/ doi: nan id: cord-018623-of9vx7og author: Saghazadeh, Amene title: The Physical Burden of Immunoperception date: 2019-04-27 words: 5755.0 sentences: 262.0 pages: flesch: 37.0 cache: ./cache/cord-018623-of9vx7og.txt txt: ./txt/cord-018623-of9vx7og.txt summary: Further, human studies provided evidence pointing to the increased development of emotional problems and EDR-related disorders in patients with various types of AIDs, such as SLE and multiple sclerosis (MS), in a disease state/severity-dependent manner [12] [13] [14] [15] [16] [17] . Thus, it is not surprising that the inflammatory response and respective cytokines are supposed as one of the possible mechanisms linking the experience of negative emotions or ER-related disorders and the progression of cardiovascular diseases, of course along with the neuroendocrine system and apoptosis signaling pathways [27, 30, [32] [33] [34] [35] . Mice subjected to short-term (1-3 weeks) HFD also exhibited anxiety-like behaviors in addition to learning and memory impairments and had significantly higher levels of homovanillic acid-a metabolite of dopamine-in their hippocampus and cortex but without any alteration in the gene expression of inflammatory markers [89] . Increased emotional distress in daughters of breast cancer patients is associated with decreased natural cytotoxic activity, elevated levels of stress hormones and decreased secretion of Th1 cytokines abstract: The previous chapter introduced the ImmunoEmotional Regulatory System (IMMERS). Also, there was a brief discussion about psychological states/psychiatric disorders that so far have been linked to the IMMERS. The present chapter considers another aspect of the IMMERS in which physiological states/physical diseases can be fit to the IMMERS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123546/ doi: 10.1007/978-3-030-10620-1_10 id: cord-331449-0sow1im8 author: Saha, Shivangi title: Managing Burns During COVID-19 Outbreak date: 2020-05-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease pandemic has affected our practice as healthcare professionals. As burn surgeons, we are obliged to provide the best possible care to our patients. However, due to the risk of viral transmission, the goal should be to provide safe care to our patients as well as ensure the safety of the whole team providing burn care. The burn patients are usually debilitated and require a prolonged hospital stay and multiple operative procedures which put them and everyone involved in their care at increased risk of coronavirus infections and transmission. This warrants special caution to the burn team while managing such patients. In this review, we aim to highlight the key considerations for burn care teams while dealing with burn patients during the COVID-19 pandemic. url: https://doi.org/10.1093/jbcr/iraa086 doi: 10.1093/jbcr/iraa086 id: cord-317604-j8b64a1a author: Sahay, Sandeep title: Management of hospitalized patients with pulmonary arterial hypertension and COVID-19 infection date: 2020-06-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32595934/ doi: 10.1177/2045894020933480 id: cord-028982-kkzpqbry author: Sahu, Dipit title: Telerehabilitation during COVID 19: Shoulder rehabilitation date: 2020-07-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351064/ doi: 10.1016/j.jse.2020.07.001 id: cord-265721-wmz3wywi author: Saini, Kamal S. title: Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy date: 2020-06-22 words: 1974.0 sentences: 99.0 pages: flesch: 35.0 cache: ./cache/cord-265721-wmz3wywi.txt txt: ./txt/cord-265721-wmz3wywi.txt summary: Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19. The pharmaceutical industry, contract research organisations (CROs), and academia have spent decades developing drugs for cancer-induced inflammation, immune dysfunction, and coagulopathy; given that this triad is also seen in patients affected by COVID-19, it is reasonable to consider testing selected anticancer agents in a rational manner against this viral illness. abstract: Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19. url: https://doi.org/10.1038/s41416-020-0948-x doi: 10.1038/s41416-020-0948-x id: cord-320695-gq7k331z author: Sairras, Shellice title: Heart Failure Hospitalizations and Risk Factors among the Multi-Ethnic Population from a Middle Income Country: The Suriname Heart Failure Studies date: 2020-09-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Heart failure (HF) is an emerging epidemic with poor disease outcomes and differences in its prevalence, etiology and management between and within world regions. Hypertension (HT) and ischemic heart disease (IHD) are the leading causes of HF. In Suriname, South-America, data on HF burden are lacking. The aim of this Suriname Heart Failure I (SUHF–I) study, is to assess baseline characteristics of HF admitted patients in order to set up the prospective interventional SUHF-II study to longitudinally determine the effectiveness of a comprehensive HF management program in HF patients. METHODS: A cross-sectional analysis was conducted of Thorax Center Paramaribo (TCP) discharge data from January 2013-December 2015. The analysis included all admissions with primary or secondary discharge of HF ICD-10 codes I50-I50.9 and I11.0 and the following variables: patient demographics (age, sex, and ethnicity), # of readmissions, risk factors (RF) for HF: HT, diabetes mellitus (DM), smoking, and left ventricle (LV) function. T-tests were used to analyze continuous variables and Chi-square test for categorical variables. Differences were considered statistically significant when a p-value <0.05 is obtained. RESULTS: 895 patients (1:1 sex ratio) with either a primary (80%) or secondary HF diagnosis were admitted. Female patients were significantly older (66.2 ± 14.8 years, p < 0.01) at first admission compared to male patients (63.5 ± 13.7 years) and the majority of admissions were of Hindustani and Creole descent. HT, DM and smoking were highly prevalent respectively 62.6%, 38.9 and 17.3%. There were 379 readmissions (29.1%) and 7% of all admissions were readmissions within 30 days and 16% were readmissions for 31-365 day. IHD is more prevalent in patients from Asian descendant (52.2%) compared to African descendant (11.7%). Whereas, HT (39.3%) is more prevalent in African descendants compared to Asian descendants (12.7%). There were no statistically significant differences in age, sex, ethnicity, LV function and RFs between single admitted and readmitted patients. CONCLUSION: RF prevalence, ethnic differences and readmission rates in Surinamese HF patients are in line with reports from other Caribbean and Latin American countries. These results are the basis for the SUHF-II study which will aid in identifying the country specific and clinical factors for the successful development of a multidisciplinary HF management program. url: https://doi.org/10.1016/j.jnma.2020.08.010 doi: 10.1016/j.jnma.2020.08.010 id: cord-339455-b8nu34vv author: Sakr, Yasser title: The clinical spectrum of pulmonary thromboembolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: A European case series date: 2020-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To describe the clinical characteristics and outcomes of coronavirus disease-2019 (COVID-19)-associated pulmonary thromboembolism (PTE). MATERIALS AND METHODS: A case series of five patients, representing the clinical spectrum of COVID-19 associated PTE. Patients were admitted to four hospitals in Germany, Italy, and France. Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was confirmed using a real-time reverse transcription polymerase chain reaction test. RESULTS: The onset of PTE varied from 2 to 4 weeks after the occurrence of the initial symptoms of SARS-CoV-2 infection and led to deterioration of the clinical picture in all cases. PTE was the primary reason for hospital admission after a 2-week period of self-isolation at home (1 patient) and hospital readmission after initial uncomplicated hospital discharge (2 patients). Three of the patients had no past history of clinically relevant risk factors for venous thromboembolism (VTE). Severe disease progression was associated with concomitant increases in IL-6, ferritin, and D-Dimer levels. The outcome from PTE was related to the extent of vascular involvement, and associated complications. CONCLUSION: PTE is a potential life-threatening complication, which occurs frequently in patients with COVID-19. Intermediate therapeutic dose of anticoagulants and extend thromboprophylaxis are necessary after meticulous risk-benefit assessment. url: https://doi.org/10.1016/j.jcrc.2020.09.021 doi: 10.1016/j.jcrc.2020.09.021 id: cord-269511-bfd1dmt3 author: Salacup, Grace title: Characteristics and Clinical Outcomes of COVID‐19 Patients in an Underserved‐Inner City Population: A Single Tertiary Center Cohort date: 2020-07-03 words: 3453.0 sentences: 229.0 pages: flesch: 51.0 cache: ./cache/cord-269511-bfd1dmt3.txt txt: ./txt/cord-269511-bfd1dmt3.txt summary: Multivariate logistic regression was Accepted Article used to look at the factors associated with inpatient mortality as primary outcome, and need for vasopressors, CRRT/HD, and mechanical ventilation as secondary outcomes. In this retrospective single center study, clinical characteristics were described, and risks factors were determined in association with inpatient death, need for intubation, need for CRRT/HD, and vasopressor use among hospitalized COVID-19 patients in an underserved minority population. Multivariate regression analysis showed that age as a continuous variable is significantly associated with inpatient mortality (p<0.001) with mean age higher amongst patient who died compared to those who survived (73 years old vs 64 years old; p<0.0001). Although African American patients, who were 70% of our study population, tended to have higher rates of obesity, hypertension, and diabetes, there were no significant difference compared to other races (see Table S2 ). Patients in this study who received COVID-19 specific treatment (steroid, tocilizumab, and hydroxychloroquine) had poor clinical outcomes. abstract: BACKGROUND: There is limited information describing the characteristics and clinical outcomes of patients infected with coronavirus disease 2019 (COVID‐19) especially those in underserved urban area with minority population in the United States. METHODS: This is a retrospective single center study for patients who were admitted with COVID‐19 infection. Data collection was from March 1 through April 24,2020. Demographic, clinical, laboratory, and treatment data were presented using descriptive statistics and frequencies. Chi‐square test and multivariate logistic regression were used to determine association of risk factors and clinical outcomes. RESULTS: A total of 242 inpatients were included with a mean age of 66 ±14.75 (±SD). 50% were female and 70% were African American. Comorbidities included hypertension (74%), diabetes mellitus (49%), and 19% had either COPD or asthma. Older age was associated with higher risk of inpatient death OR 1.056 [95% CI 1.023 to 1.090; p=0.001]. Inpatient mortality occurred in 70% who needed mechanical ventilation (OR: 29.51; 95% CI: 13.28‐65.60; p<0.0001), 58% who required continuous renal replacement therapy/hemodialysis (CRRT/HD) (OR: 6.63; 95% CI: 2.74‐16.05; p<0.0001), and 69% who needed vasopressors (OR: 30.64; 95% CI: 13.56 to 69.20; p<0.0001). Amongst biomarkers of disease severity, only baseline CRP levels (145±116 mg/L) were associated with mortality OR 1.008 [95% CI 1.003 to 1.012; p=0.002]. CONCLUSION: Majority of hospitalized patients had hypertension and diabetes. Older age was an independent risk factor for inpatient mortality. Requirement of mechanical ventilation, vasopressor use, and CRRT/HD were associated significantly with inpatient mortality. Higher baseline CRP was significantly associated with inpatient death. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32617986/ doi: 10.1002/jmv.26252 id: cord-329863-r2vqsg5r author: Salamanna, Francesca title: Overt and non-overt disseminated intravascular coagulation and the potential role of heparin in the COVID-19 pandemic outbreak date: 2020-10-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1177/2040620720951655 doi: 10.1177/2040620720951655 id: cord-317809-umb8j63t author: Salari, Abolfazl title: COVID-19 pandemic & head and neck cancer patients management: The role of virtual multidisciplinary team meetings date: 2020-04-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32291153/ doi: 10.1016/j.oraloncology.2020.104693 id: cord-321784-nubu5fuz author: Salazar, E. title: Treatment of COVID-19 Patients with Convalescent Plasma in Houston, Texas date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: COVID-19 disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally, and no proven treatments are available. Convalescent plasma therapy has been used with varying degrees of success to treat severe microbial infections for more than 100 years. Methods: Patients (n=25) with severe and/or life-threatening COVID-19 disease were enrolled at the Houston Methodist hospitals from March 28 to April 14, 2020. Patients were transfused with convalescent plasma obtained from donors with confirmed SARS-CoV-2 infection and had been symptom free for 14 days. The primary study outcome was safety, and the secondary outcome was clinical status at day 14 post-transfusion. Clinical improvement was assessed based on a modified World Health Organization 6-point ordinal scale and laboratory parameters. Viral genome sequencing was performed on donor and recipient strains. Results: At baseline, all patients were receiving supportive care, including anti-inflammatory and anti-viral treatments, and all patients were on oxygen support. At day 7 post-transfusion with convalescent plasma, nine patients had at least a 1-point improvement in clinical scale, and seven of those were discharged. By day 14 post-transfusion, 19 (76%) patients had at least a 1-point improvement in clinical status and 11 were discharged. No adverse events as a result of plasma transfusion were observed. The whole genome sequencing data did not identify a strain genotype-disease severity correlation. Conclusions: The data indicate that administration of convalescent plasma is a safe treatment option for those with severe COVID-19 disease. Randomized, controlled trials are needed to determine its efficacy. url: https://doi.org/10.1101/2020.05.08.20095471 doi: 10.1101/2020.05.08.20095471 id: cord-274860-7ec2jcoq author: Salazar, Eric title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date: 2020-11-04 words: 4738.0 sentences: 234.0 pages: flesch: 47.0 cache: ./cache/cord-274860-7ec2jcoq.txt txt: ./txt/cord-274860-7ec2jcoq.txt summary: title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG We recently reported results from interim analysis of a propensity-score matched study suggesting that early treatment of COVID-19 patients with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG significantly decreases mortality. In the aggregate, the analysis confirms and extends our previous preliminary finding that transfusion of COVID-19 patients soon after hospitalization with high titer anti-spike protein RBD IgG present in convalescent plasma significantly reduces mortality. In our previous study, interim analysis revealed that, relative to matched controls, patients transfused with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG within 72 hrs of hospital admission had significantly reduced mortality at 28 days post-transfusion. The data confirm our previous findings that transfusion of patients soon after hospital admission with high titer anti-spike protein RBD IgG present in convalescent plasma significantly decreases mortality. abstract: Coronavirus disease 2019 (COVID-19) convalescent plasma has emerged as a promising therapy and has been granted emergency use authorization by the U.S. Food and Drug Administration (FDA) for hospitalized COVID-19 patients. We recently reported results from interim analysis of a propensity-score matched study suggesting that early treatment of COVID-19 patients with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG significantly decreases mortality. We here present results from 60-day follow up of our cohort of 351 transfused hospitalized patients. Prospective determination of ELISA anti-RBD IgG titer facilitated selection and transfusion of the highest titer units available. Retrospective analysis by the Ortho VITROS IgG assay revealed a median signal/cutoff (S/C) ratio of 24.0 for transfused units, a value far exceeding the recently FDA-required cutoff of 12.0 for designation of high titer convalescent plasma. With respect to altering mortality, our analysis identified an optimal window of 44 hours post-hospitalization for transfusing COVID-19 patients with high titer convalescent plasma. In the aggregate, the analysis confirms and extends our previous preliminary finding that transfusion of COVID-19 patients soon after hospitalization with high titer anti-spike protein RBD IgG present in convalescent plasma significantly reduces mortality. url: https://www.ncbi.nlm.nih.gov/pubmed/33157066/ doi: 10.1016/j.ajpath.2020.10.008 id: cord-297832-picpuzvo author: Salazar, Rafael title: Decreased Mortality in Patients With Severe Bronchospasm Associated With SARS-CoV-2: An Alternative to Invasive Mechanical Ventilation date: 2020-10-06 words: 1768.0 sentences: 110.0 pages: flesch: 47.0 cache: ./cache/cord-297832-picpuzvo.txt txt: ./txt/cord-297832-picpuzvo.txt summary: The number of patients with acute episodes of severe bronchospasm needing intubation and ventilatory support has increased rapidly during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) pandemic. Anteroposterior chest X-ray at the time of acute bronchospasm with Radiographic Assessment of Lung Edema (RALE) score 2 The initial management comprised placing the patient in the prone position and administering oxygen at high flow through a non-rebreather mask with flow between 10 and 15 liters per minute until reaching 100% FiO 2 . To improve ventilatory mechanics and ultimately postpone the need for IMV due to acute bronchospasm in patients diagnosed with COVID-19, we put in place a therapeutic approach consisting of early respiratory therapy and pharmacological bronchospasm rescue approach. The therapeutic bundle of early respiratory therapy, consisting of deep inspiration with inspiratory hold, and pharmacological bronchospasm rescue decreased the need for invasive mechanical ventilation in patients with bronchospasm associated with SARS-CoV-2 and reduced the mortality rate. abstract: The number of patients with acute episodes of severe bronchospasm needing intubation and ventilatory support has increased rapidly during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) pandemic. Although medical consensus upholds the use of ventilatory support in this pathology, its survival benefits remain unclear. To improve the outcomes and survival rates, a bundle of early respiratory therapy with a pharmacological rescue regimen was provided to four patients with bronchospasm secondary to COVID-19. This therapeutic approach successfully delayed the need for invasive mechanical ventilation for 48 hours and decreased the mortality rate in all cases. url: https://www.ncbi.nlm.nih.gov/pubmed/33173630/ doi: 10.7759/cureus.10822 id: cord-018243-hyvu9nuq author: Salman, Huda title: Fibrosing Alveolitis in Hematologic Malignancy Patients Undergoing Hematopoietic Cell Transplantation date: 2010-08-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Although advances in antineoplastic therapy have considerably improved the survival of patients with hematological malignancies, current treatment modalities increase the risk of late complications. Several forms of chronic pulmonary dysfunction due to infectious or noninfectious causes commonly occur in the months to years after chemo-radiotherapy and can be fatal or result in long-term morbidity. The judicious use of prophylactic antimicrobial agents has tipped the balance toward noninfectious etiologies. Hence, while opportunistic infections still contribute to chronic lung disease, late sequelae resulting from antineoplastic therapy have been identified and reported. Patients who proceed to receive hematopoietic cell transplantation (HSCT) are particularly prone to developing lung complications. Pulmonary dysfunction occurring after HSCT may manifest with obstructive or restrictive pulmonary mechanics and may range in severity from subtle, subclinical functional changes to frank respiratory failure. Insights generated using animal models suggest that the immunologic mechanisms contributing to lung inflammation after HSCT may be similar to those responsible for graft-versus host disease. In sum, chronic fibrotic pulmonary dysfunction is a frequent and significant complication facing survivors of hematologic malignancies and their practitioners. The high incidence and suboptimal response to current support care and immunosuppressive therapy underscore the need for heightened awareness and continued research in this area. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123073/ doi: 10.1007/978-3-642-15742-4_42 id: cord-320634-x7a3k5xu author: Salna, Michael title: Reply: A problem of “ethic” proportions date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.jtcvs.2020.07.030 doi: 10.1016/j.jtcvs.2020.07.030 id: cord-313684-61hkogdh author: Samaddar, Arghadip title: Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena date: 2020-09-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in the Wuhan City of China in December 2019 and evolved into a global pandemic. To date, there are no proven drugs or vaccines against this virus. Hence, the situation demands an urgent need to explore all potential therapeutic strategies that can be made available to prevent the disease progression and improve patient outcomes. In absence of clinically proven treatment guidelines, several repurposed drugs and investigational agents are currently being evaluated in clinical trials for their probable benefits in the treatment of COVID-19. These include antivirals (remdesivir, lopinavir/ritonavir, umifenovir, and favipiravir), interferon, antimalarials (chloroquine/hydroxychloroquine), antiparasitic drugs (ivermectin and nitazoxanide), biologics (monoclonal antibodies and interleukin receptor antagonist), cellular therapies (mesenchymal stem cells and natural killer cells), convalescent plasma, and cytokine adsorber. Though several observational studies have claimed many of these agents to be effective based on their in vitro activities and extrapolated evidence from SARS and Middle East respiratory syndrome (MERS) epidemics, the currently available data remains inconclusive because of ill-defined patient selection criteria, small sample size, lack of concurrent controls, and use of intermediary outcomes instead of patient-relevant outcomes. Moreover, there is a need to clearly define the patient populations who warrant therapy and also the timing of initiation of treatment. Understanding the disease pathology responsible for the clinical manifestations of COVID-19 is imperative to identify the potential targets for drug development. This review explains the pathophysiology of COVID-19 and summarizes the potential treatment candidates, which can provide guidance in developing effective therapeutic strategies. url: https://doi.org/10.3389/fphar.2020.585888 doi: 10.3389/fphar.2020.585888 id: cord-336882-x9e6r0h0 author: Sambare, Tanmaya title: Preparing for an Era of Episode-Based Care in Total Joint Arthroplasty date: 2020-09-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: With a history of steadily rising healthcare costs, the United States faces an unprecedented set of health and financial challenges. The COVID-19 pandemic will only exacerbate these challenges, and it is of paramount importance to reform and refine health systems to maximize the value of care delivered to the patient. Recent developments related to value improvement in total joint arthroplasty suggest episode-based payment is likely to become standard practice given the current healthcare environment. Consequently, developing episode-based care models for total joint arthroplasty is in the best interests of surgeons, health systems, and patients. In this article, we review important developments related to value-based care in total joint arthroplasty and present an episode-based framework for delivering high value, patient-centric care. We examine each phase of a total joint arthroplasty episode – pre-operative, acute, post-acute, and follow up – and present several ideas with developing bodies of evidence that can improve the value of care delivered to the patient. url: https://api.elsevier.com/content/article/pii/S0883540320310391 doi: 10.1016/j.arth.2020.09.028 id: cord-259229-e8m8m4ut author: Samidurai, Arun title: Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic Strategies date: 2020-09-16 words: 10768.0 sentences: 530.0 pages: flesch: 38.0 cache: ./cache/cord-259229-e8m8m4ut.txt txt: ./txt/cord-259229-e8m8m4ut.txt summary: Emerging evidence reveals a direct interplay between COVID-19 and dire cardiovascular complications, including myocardial injury, heart failure, heart attack, myocarditis, arrhythmias as well as blood clots, which are accompanied with elevated risk and adverse outcome among infected patients, even sudden death. Respiratory illness and acute cardiac injury are major clinical manifestations observed in patients infected with SARS-CoV-2 during the late stage complications of the disease [38] . Based on the available clinical data, potential myocardial injury is a relevant challenge among hospitalized patients with COVID-19 with increased risk of mortality; therefore, it is essential for multidisciplinary assessment, including blood pressure control in hypertensive patients as well as cardiovascular evaluation and therapy to reduce the morality for COVID-19 infection. Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients with Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China abstract: The outbreak of coronavirus disease 2019 (COVID-19), an infectious disease with severe acute respiratory syndrome, has now become a worldwide pandemic. Despite the respiratory complication, COVID-19 is also associated with significant multiple organ dysfunction, including severe cardiac impairment. Emerging evidence reveals a direct interplay between COVID-19 and dire cardiovascular complications, including myocardial injury, heart failure, heart attack, myocarditis, arrhythmias as well as blood clots, which are accompanied with elevated risk and adverse outcome among infected patients, even sudden death. The proposed pathophysiological mechanisms of myocardial impairment include invasion of SARS-CoV-2 virus via angiotensin-converting enzyme 2 to cardiovascular cells/tissue, which leads to endothelial inflammation and dysfunction, de-stabilization of vulnerable atherosclerotic plaques, stent thrombosis, cardiac stress due to diminish oxygen supply and cardiac muscle damage, and myocardial infarction. Several promising therapeutics are under investigation to the overall prognosis of COVID-19 patients with high risk of cardiovascular impairment, nevertheless to date, none have shown proven clinical efficacy. In this comprehensive review, we aimed to highlight the current integrated therapeutic approaches for COVID-19 and we summarized the potential therapeutic options, currently under clinical trials, with their mechanisms of action and associated adverse cardiac events in highly infectious COVID-19 patients. url: https://doi.org/10.3390/ijms21186790 doi: 10.3390/ijms21186790 id: cord-271887-blwrpf38 author: Sampa, Masuda Begum title: Redesigning Portable Health Clinic Platform as a Remote Healthcare System to Tackle COVID-19 Pandemic Situation in Unreached Communities date: 2020-06-30 words: 5654.0 sentences: 271.0 pages: flesch: 47.0 cache: ./cache/cord-271887-blwrpf38.txt txt: ./txt/cord-271887-blwrpf38.txt summary: Our initial examination of the suitability of the PHC and its associated technologies as a key contributor to public health responses is designed to "flatten the curve", particularly among unreached high-risk NCD populations in developing countries. Portable Health Clinic (PHC) services, which is an RHS, have proven efficacy in providing necessary information and preventive measures for people without access to healthcare facilities [17] [18] [19] . No previous study to date has examined the scopes of designing and developing an RHS based on the general requirements to facilitate primary screening and triaging COVID-19 and primary healthcare services for preventing COVID-19 and controlling NCDs. However, such screening and triaging COVID-19 by an RHS is important for cost-effective check-ups and for reducing the risk of transmission for unreached communities with various needs. In its existing functional form, deploying the PHC and related RHS technologies for socially distanced populations during a public health emergency, such as the COVID-19 pandemic, is beneficial in reducing the risk of transmission to frontline healthcare professionals. abstract: Medical staff carry an inordinate risk of infection from patients, and many doctors, nurses, and other healthcare workers are affected by COVID-19 worldwide. The unreached communities with noncommunicable diseases (NCDs) such as chronic cardiovascular, respiratory, endocrine, digestive, or renal diseases became more vulnerable during this pandemic situation. In both cases, Remote Healthcare Systems (RHS) may help minimize the risk of SARS-CoV-2 transmission. This study used the WHO guidelines and Design Science Research (DSR) framework to redesign the Portable Health Clinic (PHC), an RHS, for the containment of the spread of COVID-19 as well as proposed corona logic (C-Logic) for the main symptoms of COVID-19. Using the distributed service platform of PHC, a trained healthcare worker with appropriate testing kits can screen high-risk individuals and can help optimize triage to medical services. PHC with its new triage algorithm (C-Logic) classifies the patients according to whether the patient needs to move to a clinic for a PCR test. Through modified PHC service, we can help people to boost their knowledge, attitude (feelings/beliefs), and self-efficacy to execute preventing measures. Our initial examination of the suitability of the PHC and its associated technologies as a key contributor to public health responses is designed to “flatten the curve”, particularly among unreached high-risk NCD populations in developing countries. Theoretically, this study contributes to design science research by introducing a modified healthcare providing model. url: https://doi.org/10.3390/ijerph17134709 doi: 10.3390/ijerph17134709 id: cord-261025-y49su5uc author: Sampathkumar, Priya title: SARS: Epidemiology, Clinical Presentation, Management, and Infection Control Measures date: 2003-07-31 words: 3952.0 sentences: 200.0 pages: flesch: 49.0 cache: ./cache/cord-261025-y49su5uc.txt txt: ./txt/cord-261025-y49su5uc.txt summary: Severe acute respiratory syndrome (SARS) is a recently recognized febrile respiratory illness that first appeared in southern China in November 2002, has since spread to several countries, and has resulted in more than 8000 cases and more than 750 deaths. This article summarizes currently available information regarding the epidemiology, clinical features, etiologic agent, and modes of transmission of the disease, as well as infection control measures appropriate to contain SARS. An RT-PCR test specific for RNA from the SARS-CoV has been positive within the first 10 days after fever onset in respiratory specimens from most patients considered probable cases of SARS who have been tested and in stool samples in the second week of illness. Case definitions of SARS are currently based on the presence of epidemiological risk factors (close contact with patients with SARS or travel to SARS-affected areas) and a combination of fever and respiratory symptoms, with or without chest radiographic changes. Severe Acute Respiratory Syndrome (SARS) in Singapore: clinical features of index patient and initial contacts abstract: Severe acute respiratory syndrome (SARS) is a recently recognized febrile respiratory illness that first appeared in southern China in November 2002, has since spread to several countries, and has resulted in more than 8000 cases and more than 750 deaths. The disease has been etiologically linked to a novel coronavirus that has been named the SARS-associated coronavirus. It appears to be spread primarily by large droplet transmission. There is no specific therapy, and management consists of supportive care. This article summarizes currently available information regarding the epidemiology, clinical features, etiologic agent, and modes of transmission of the disease, as well as infection control measures appropriate to contain SARS. url: https://www.sciencedirect.com/science/article/pii/S002561961162689X doi: 10.4065/78.7.882 id: cord-313494-a4pms2ub author: Sampedro, Ana Diez title: COVID-19 and Advanced Practice Registered Nurses (APRNs): Frontline update #1 date: 2020-06-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 emerged in 2019 and rapidly became a global pandemic infecting millions, killing hundreds of thousands. The disease altered the practices of hospitals, clinics, and patients. These changes have implications for Advanced Practice Registered Nurses (APRNs). APRNs must remain current on best practices for treatment and diagnosis of COVID-19 while being cognizant of changes to their scope of practice. As the pandemic continues, APRNs will remain on the front lines treating COVID-19 patients while also caring for vulnerable populations within the community. To provide high-quality care, APRNs must utilize a multi-faceted approach that heeds ongoing updates to evidence-based practice. url: https://doi.org/10.1016/j.nurpra.2020.06.014 doi: 10.1016/j.nurpra.2020.06.014 id: cord-325933-1qvpofvp author: Samrah, Shaher M title: Depression and Coping Among COVID-19-Infected Individuals After 10 Days of Mandatory in-Hospital Quarantine, Irbid, Jordan date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: In-hospital mandatory quarantine of asymptomatic and symptomatic COVID-19-infected individuals was part of the national control strategy used to prevent the spread of the COVID-19 outbreak in Jordan. This study aims to evaluate depression, associated stressors, and various coping methods used among adult quarantined COVID-19-infected individuals. METHODS: This cross-sectional study included all COVID-19-infected individuals who were obligatorily quarantined at King Abdullah University Hospital, Irbid, Jordan from March 15 to April 20, 2020. Symptoms of depression were assessed using the 9-item Patient Health Questionnaire after 10 days of quarantine. In addition, several questions regarding the patients’ sights with the health-care system, and coping methods were added. Demographic characteristics, clinical presentation, and comorbidities were collected from the medical records. RESULTS: Out of 91 quarantined COVID-19 patients, a total of 66 completed the survey, with a participation rate of 72.5%. The majority were relatively young; the mean ± SD age was 35.8 ± 16.2 years (range 18–79), 59.1% were females and 47% were asymptomatic. A considerable proportion of patients (44%) reported symptoms of depression, with 21% were at high risk of major depressive disorder. Depression symptoms were significantly more common among females than males [PHQ-9 score ≥10: 13 (92.9%) vs 1 (7.1%), respectively; p=0.004]. The majority of patients (71.2%) reported having problems with health-care services. Insufficient involvement in making treatment decisions was the most commonly reported concern (59.1%). Patients who reported problems in maintaining privacy, reaching out to their physicians, or receiving conflicting information from the medical staff, had more symptoms of depression compared with the satisfied ones (p<0.05). On the other hand, those who were receiving sufficient support from the family, friends, or medical staff during quarantine, were less likely to have depression symptoms (p<0.05). Furthermore, symptoms of depression were less in patients who stayed in touch with others using phone calls, texting, or social media (p=0.024). CONCLUSION: Symptoms of depression were common among both symptomatic and asymptomatic quarantined COVID-19 patients. The support of family, friends, and medical staff was an essential alleviating factor. Facilitating adequate communication may promote the mental well-being of COVID-19-infected patients and help in reducing the risk of depression during the in-hospital quarantine. url: https://doi.org/10.2147/prbm.s267459 doi: 10.2147/prbm.s267459 id: cord-260857-oxxle915 author: Samuel, Sharmeen title: INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc). date: 2020-07-01 words: 4183.0 sentences: 217.0 pages: flesch: 47.0 cache: ./cache/cord-260857-oxxle915.txt txt: ./txt/cord-260857-oxxle915.txt summary: BACKGROUND: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially pro-arrhythmic Hydroxychloroquine (HCQ) and Azithromycin (AZN). Additionally, some of the medications that have been used for treatment of COVID-19 infection, such as Hydroxychloroquine (HCQ) and Azithromycin (AZN), are known to cause corrected QT (QTc) interval prolongation, therefore potentially predisposing patients to malignant ventricular arrhythmia.s 6, 7 However, there is little current data on the electrophysiologic consequences of these drugs in the setting of active COVID-19 in pediatric patients. As per hospital protocol, COVID-19 specific medications including HCQ with or without AZN were initiated at the discretion of the Infectious Disease team for patients needing supplemental oxygen for hypoxia in the setting of positive SARS-CoV-2, if the baseline QTc was less than 480 milliseconds (msec) measured on lead II via 15 lead ECG or telemetry. abstract: BACKGROUND: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially pro-arrhythmic Hydroxychloroquine (HCQ) and Azithromycin (AZN). OBJECTIVES: To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment. METHODS: A single center retrospective chart review was undertaken and included all patients with 1) symptoms of COVID-19, and 2) PCR (+) nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. RESULTS: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (non-sustained (ns) ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic anti-arrhythmic therapy. Patients with significant arrhythmias were likely to have non-cardiac co-morbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, p=1). The use of HCQ with or without AZN was associated with statistically significant QTc prolongation (411+19 msec vs 426+15 msec, p<0.0001). QTc was not statistically different in patients with and without arrhythmias (425+15 msec vs 425+15 msec, p=1). CONCLUSIONS: In pediatric patients with PCR positive active COVID-19 infection, significant arrhythmias are infrequent, but more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation, but was not associated with arrhythmias in pediatric patients. url: https://www.sciencedirect.com/science/article/pii/S1547527120306329?v=s5 doi: 10.1016/j.hrthm.2020.06.033 id: cord-305786-06dpjik8 author: Sandora, Thomas J. title: Pneumonia in Hospitalized Children date: 2005-07-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Pneumonia is one of the most common infections in the pediatric age group and one of the leading diagnoses that results in overnight hospital admission for children. Various micro-organisms can cause pneumonia, and etiologies differ by age. Clinical manifestations vary, and diagnostic testing is frequently not standardized. Hospital management should emphasize timely diagnosis and prompt initiation of antimicrobial therapy when appropriate. Issues of particular relevance to inpatient management are emphasized in this article. url: https://api.elsevier.com/content/article/pii/S0031395505000672 doi: 10.1016/j.pcl.2005.03.004 id: cord-322552-95bj65qf author: Sang, Charlie Joseph title: ST Elevations in the Era of COVID-19 date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Myocardial injury, represented by elevated cardiac enzymes, has been associated with increased morbidity and mortality in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections. Coronavirus disease 2019 (COVID-19) has created unique challenges in approaching patients with acute ST-segment changes. We describe two distinct cases of ST elevation on electrocardiogram occurring in patients with COVID-19 and review important diagnostic and management considerations for the front-line clinician. url: https://www.ncbi.nlm.nih.gov/pubmed/32855827/ doi: 10.1155/2020/8845627 id: cord-337622-rc9pejmo author: Sansom‐Daly, Ursula M. title: Grappling with the ‘human’ problem hiding behind the technology: Telehealth during and beyond COVID‐19 date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1002/pon.5462 doi: 10.1002/pon.5462 id: cord-263292-qjfe2t9v author: Sansone, A. title: Addressing male sexual and reproductive health in the wake of COVID-19 outbreak date: 2020-07-13 words: 3912.0 sentences: 210.0 pages: flesch: 39.0 cache: ./cache/cord-263292-qjfe2t9v.txt txt: ./txt/cord-263292-qjfe2t9v.txt summary: Despite being a trivial matter for patients in intensive care units (ICUs), erectile dysfunction (ED) is a likely consequence of COVID-19 for survivors, and considering the high transmissibility of the infection and the higher contagion rates among elderly men, a worrying phenomenon for a large part of affected patients. Testicular function in COVID-19 patients requires careful investigation for the unclear association with testosterone deficiency and the possible consequences for reproductive health. However, independently of whether testosterone is a friend or foe for COVID-19, it should be acknowledged that the testis is a target for SARS-CoV-2 and the possibility for long-lasting consequences on the endocrine function exists, even for recovered patients. Drugs such as β-blockers and antihypertensive agents, routinely used in COVID-19 patients, have the potential to impair sexual function [41] ; therefore, both the cardiovascular consequences and their treatment might ease progression from subclinical to a clinically overt ED [42, 43] . abstract: PURPOSE: The COVID-19 pandemic, caused by the SARS-CoV-2, represents an unprecedented challenge for healthcare. COVID-19 features a state of hyperinflammation resulting in a “cytokine storm”, which leads to severe complications, such as the development of micro-thrombosis and disseminated intravascular coagulation (DIC). Despite isolation measures, the number of affected patients is growing daily: as of June 12th, over 7.5 million cases have been confirmed worldwide, with more than 420,000 global deaths. Over 3.5 million patients have recovered from COVID-19; although this number is increasing by the day, great attention should be directed towards the possible long-term outcomes of the disease. Despite being a trivial matter for patients in intensive care units (ICUs), erectile dysfunction (ED) is a likely consequence of COVID-19 for survivors, and considering the high transmissibility of the infection and the higher contagion rates among elderly men, a worrying phenomenon for a large part of affected patients. METHODS: A literature research on the possible mechanisms involved in the development of ED in COVID-19 survivors was performed. RESULTS: Endothelial dysfunction, subclinical hypogonadism, psychological distress and impaired pulmonary hemodynamics all contribute to the potential onset of ED. Additionally, COVID-19 might exacerbate cardiovascular conditions; therefore, further increasing the risk of ED. Testicular function in COVID-19 patients requires careful investigation for the unclear association with testosterone deficiency and the possible consequences for reproductive health. Treatment with phosphodiesterase-5 (PDE5) inhibitors might be beneficial for both COVID-19 and ED. CONCLUSION: COVID-19 survivors might develop sexual and reproductive health issues. Andrological assessment and tailored treatments should be considered in the follow-up. url: https://doi.org/10.1007/s40618-020-01350-1 doi: 10.1007/s40618-020-01350-1 id: cord-353697-ocxextfj author: Santana, Monique Freire title: Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management date: 2020-07-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically. url: https://doi.org/10.1590/0037-8682-0401-2020 doi: 10.1590/0037-8682-0401-2020 id: cord-254382-xy8se56o author: Santos, C. title: Comparative Incidence and Outcomes of COVID-19 in Kidney or Kidney-Pancreas Transplant Recipients Versus Kidney or Kidney-Pancreas Waitlisted Patients: A Pilot Study date: 2020-07-25 words: 3660.0 sentences: 243.0 pages: flesch: 42.0 cache: ./cache/cord-254382-xy8se56o.txt txt: ./txt/cord-254382-xy8se56o.txt summary: In this retrospective cohort pilot study, we determined the incidence and outcomes of COVID-19 in kidney or kidney-pancreas transplant recipients and kidney or kidney-pancreas waitlisted patients in our center. We hypothesize that these patients have an incidence proportion of COVID-19 similar to the general population, but that transplanted patients have greater occurrences of hospitalization, intensive care unit admission, mechanical ventilation and death compared to waitlisted patients due to chronic immunosuppression. Demographic data, vital signs (temperature and body mass index), laboratory results, hospitalization, intensive care unit admission, mechanical ventilation, and death were captured from the electronic datasets, whereas comorbidities, organ type, cause of renal disease, induction and maintenance immunosuppression, presenting symptoms for COVID-19, oxygen supplementation, chest radiographic findings, and treatments tried for COVID-19 were collected by manual chart review. . https://doi.org/10.1101/2020.07.20.20157990 doi: medRxiv preprint Previous epidemiologic studies on COVID-19 in kidney transplant recipients focused on assembling cohorts of patients diagnosed with COVID-19 and describing their clinical features and outcomes. abstract: Comparative COVID-19 epidemiologic studies between immunosuppressed and immunocompetent patients may provide insight into the impact of immunosuppressive medications on clinical outcomes. In this retrospective cohort pilot study, we determined the incidence and outcomes of COVID-19 in kidney or kidney-pancreas transplant recipients and kidney or kidney-pancreas waitlisted patients in our center. COVID-19 testing was performed in 63 of 537 kidney or kidney-pancreas transplanted patients, versus 43 of 383 kidney or kidney-pancreas waitlisted patients as of June 4, 2020 (12% versus 11%, p=0.81). COVID-19 was identified in 14 of 537 kidney or kidney-pancreas transplanted patients, versus 9 of 383 kidney or kidney-pancreas waitlisted patients (2.6% versus 2.3%, p=0.81). Hospitalization occurred in 11 of 14 transplanted patients, and 4 of 9 waitlisted patients with COVID-19 (79% versus 44%, p=0.18). Intensive care unit admission occurred in 5 of 14 transplanted patients, and 1 of 9 waitlisted patients with COVID-19 (36% versus 11%, p=0.34). Two transplanted patients with COVID-19 were mechanically ventilated and died, whereas no waitlisted patients with COVID-19 died or were mechanically ventilated. Our study provides preliminary data that can be used for power calculations to inform multicenter studies designed to validate these findings. url: https://doi.org/10.1101/2020.07.20.20157990 doi: 10.1101/2020.07.20.20157990 id: cord-281729-z321pebe author: Santos, Cláudia title: Pathophysiology of acute fibrinous and organizing pneumonia – Clinical and morphological spectra date: 2019-05-02 words: 3045.0 sentences: 150.0 pages: flesch: 36.0 cache: ./cache/cord-281729-z321pebe.txt txt: ./txt/cord-281729-z321pebe.txt summary: Three clinical cases of patients presenting severe lung disease requiring mechanical ventilation and prolonged intensive care fitted on the variable spectra of AFOP histopathology and had poor outcome: a 23 year-old women had AFOP in the context of antiphospholipid syndrome pulmonary compromise; a 35 year-old man developed a letal intensive care pneumonia with AFOP pattern registered in post-mortem biopsy; and a 79 year-old man died 21 days after intensive care unit treatment of a sub-pleural organizing pneumonia with intra-alveolar fibrin, seen in post-mortem biopsy. Reporting these three clinical cases had the purpose to highlight the acute presentation of AFOP as a particular lung disease more recently described, initially confused with pneumonia, running with severe respiratory failure and immediate need for mechanic ventilation, with no response to antibiotics or steroids. abstract: Acute Fibrinous and Organizing Pneumonitis (AFOP) is a disease with histopathological pattern characterized by the presence of intra-alveolar fibrin in the form of fibrin “balls” and organizing pneumonia represented by inflammatory myofibroblastic polyps. Symptoms of this rare interstitial pulmonary disease can be either acute or sub-acute and it can rapidly progress to death. Diagnosis should be considered in the Intensive Care Unit (ICU) if patients’ symptomatology and radiology correlates with non-responding or progressive pneumonia and when morphology, on biopsies, encompasses criteria of diffuse alveolar damage (DAD) and organizing pneumonia (OP) balancing in between. Three clinical cases of patients presenting severe lung disease requiring mechanical ventilation and prolonged intensive care fitted on the variable spectra of AFOP histopathology and had poor outcome: a 23 year-old women had AFOP in the context of antiphospholipid syndrome pulmonary compromise; a 35 year-old man developed a letal intensive care pneumonia with AFOP pattern registered in post-mortem biopsy; and a 79 year-old man died 21 days after intensive care unit treatment of a sub-pleural organizing pneumonia with intra-alveolar fibrin, seen in post-mortem biopsy. The predominance of acute fibrin alveolar deposition pattern is helpful in raising AFOP differential diagnosis while organizing pneumonia pattern establishes a wider range of diagnosis that can go till solitary pulmonary nodule, remaining indefinite to suggest diagnosis. The performance time of biopsy in a larger number of clinical cases may be helpful in establishing the evolutionary morphological pattern, taking in mind the poor outcome of the disease, deserving rapid diagnosis to define treatment. url: https://www.sciencedirect.com/science/article/pii/S0928468018303584 doi: 10.1016/j.pathophys.2019.04.001 id: cord-284545-vn60yd46 author: Sanyaolu, Adekunle title: Comorbidity and its Impact on Patients with COVID-19 date: 2020-06-25 words: 3742.0 sentences: 182.0 pages: flesch: 49.0 cache: ./cache/cord-284545-vn60yd46.txt txt: ./txt/cord-284545-vn60yd46.txt summary: Furthermore, older patients, especially those 65 years old and above who have comorbidities and are infected, have an increased admission rate into the intensive care unit (ICU) and mortality from the COVID-19 disease. This article is part of the Topical Collection on Covid-19 * Adekunle Sanyaolu sanyakunle@hotmail.com 1 Federal Ministry of Health, Abuja, Nigeria A retrospective study of middle-aged and elderly patients with COVID-19 found that the elderly population is more susceptible to this illness and is more likely to be admitted to the ICU with a higher mortality rate [3] . Authorities speculate that subjects with comorbidities were linked to a more severe disease outcome when infected with the novel coronavirus when compared with patients with no underlying disease [31] . Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China abstract: A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in Wuhan, China, in December 2019. Since then, the virus has made its way across the globe to affect over 180 countries. SARS-CoV-2 has infected humans in all age groups, of all ethnicities, both males and females while spreading through communities at an alarming rate. Given the nature of this virus, there is much still to be learned; however, we know that the clinical manifestations range from a common cold to more severe diseases such as bronchitis, pneumonia, severe acute respiratory distress syndrome (ARDS), multi-organ failure, and even death. It is believed that COVID-19, in those with underlying health conditions or comorbidities, has an increasingly rapid and severe progression, often leading to death. This paper examined the comorbid conditions, the progression of the disease, and mortality rates in patients of all ages, infected with the ongoing COVID-19 disease. An electronic literature review search was performed, and applicable data was then collected from peer-reviewed articles published from January to April 20, 2020. From what is known at the moment, patients with COVID-19 disease who have comorbidities, such as hypertension or diabetes mellitus, are more likely to develop a more severe course and progression of the disease. Furthermore, older patients, especially those 65 years old and above who have comorbidities and are infected, have an increased admission rate into the intensive care unit (ICU) and mortality from the COVID-19 disease. Patients with comorbidities should take all necessary precautions to avoid getting infected with SARS CoV-2, as they usually have the worst prognosis. url: https://doi.org/10.1007/s42399-020-00363-4 doi: 10.1007/s42399-020-00363-4 id: cord-352914-jccxzit1 author: Sanz Herrero, Francisco title: Methylprednisolone added to tocilizumab reduces mortality in SARS‐CoV‐2 pneumonia: An observational study date: 2020-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Although there are few randomized controlled trials (RCTs) evaluating the efficacy of drugs to treat COVID‐19, different molecules have been used empirically and with great interest in those intended to control the excessive inflammatory response produced by SARS‐CoV‐2. By blocking the IL‐6 receptor, tocilizumab has a role in controlling the inflammatory response. Clinical improvement of respiratory parameters and hospital stay have been described in small series in a series of patients without a control group [1]. There are currently numerous ongoing clinical trials aimed to clarifying the role of this molecule in COVID‐19. The guidelines for the treatment of SARS‐CoV‐2 pneumonia from the Spanish Ministry of Health contemplate the use of tocilizumab as a therapeutic tool for those patients with severe respiratory failure or rapid respiratory deterioration with criteria for admission to the intensive care unit (ICU). url: https://www.ncbi.nlm.nih.gov/pubmed/32603493/ doi: 10.1111/joim.13145 id: cord-321064-pe8466n1 author: Saraceni, Francesco title: Severe COVID‐19 in a patient with chronic graft‐versus‐host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Graft‐versus‐host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T‐cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in severe COVID‐19 cases appears to be related to a massive production of pro‐inflammatory cytokines. The selective JAK1/2 inhibitor ruxolitinib has shown promising results in the context of GVHD, and different trials are currently underway in patients with severe COVID‐19; nevertheless, no clinical observation of safety or efficacy of treatment with ruxolitinib in this context has been published yet. We describe a first case of severe COVID‐19 developed after hematopoietic stem cell transplantation in a patient with a concomitant chronic GVHD (cGVHD), in which a treatment with ruxolitinib was administered with good tolerance and positive outcome. url: https://www.ncbi.nlm.nih.gov/pubmed/32629531/ doi: 10.1111/tid.13401 id: cord-355885-pg6mpuk5 author: Saracoglu, Kemal T. title: Airway management strategies for the Covid 19 patients: A brief narrative review date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: • Airway management of patients with Covid-19 is a high risk procedure. • There is an international attention to develop recommendations for the strategies. • The airway should be considered as potentially difficult and complicated. • Triaging, personal protective equipment and isolation areas may cause challenges. url: https://www.sciencedirect.com/science/article/pii/S0952818020308473?v=s5 doi: 10.1016/j.jclinane.2020.109954 id: cord-275260-xuhxqkyj author: Sardu, Celestino title: Hyperglycaemia on admission to hospital and COVID-19 date: 2020-07-06 words: 1203.0 sentences: 67.0 pages: flesch: 46.0 cache: ./cache/cord-275260-xuhxqkyj.txt txt: ./txt/cord-275260-xuhxqkyj.txt summary: The analysis of the data obtained on a very large population (1317 patients) provided important information, highlighting a role for BMI in disease severity, but did not correctly interpret the data on the role of hyperglycaemia at admission to hospital. Moreover, increased plasma glucose on admission to hospital was associated with poorer outcomes in patients with mild, moderate and severe COVID-19 [2] [3] [4] . To investigate the role of early glycaemic control in the outcomes of patients with COVID-19, we studied 132 consecutive hospitalised hyperglycaemic patients with moderate disease, admitted to Infectious diseases departments (Vanvitelli University, Naples Italy; San Sebastiano Caserta Hospital, Caserta, Italy). Fig. 1 (a) Blood glucose levels on admission to hospital and after 24 h for patients with (n = 60) and without severe disease (n = 72) at 20 days after hospitalisation. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32632527/ doi: 10.1007/s00125-020-05216-2 id: cord-323906-ro078y52 author: Sardu, Celestino title: Implications of AB0 blood group in hypertensive patients with covid-19 date: 2020-08-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Hypertension is the most frequent co-morbidity in patients with covid-19 infection, and we might speculate that a specific blood group could play a key role in the clinical outcome of hypertensive patients with covid-19. METHODS: In this prospective study, we compared 0 vs. non-0 blood group in hypertensive patients with covid-19 infection. In these patients, we evaluated inflammatory and thrombotic status, cardiac injury, and death events. RESULTS: Patients in non-0 (n = 92) vs. 0 blood group (n = 72) had significantly different values of activated pro-thrombin time, D-dimer, and thrombotic indexes as Von Willebrand factor and Factor VIII (p < 0.05). Furthermore, patients in non-0 vs. 0 blood group had higher rate of cardiac injury (10 (13.9%) vs. 27 (29.3%)) and death, (6 (8.3%) vs. 18 (19.6%)), (p < 0.05). At the multivariate analysis, Interleukin-6 (1.118, CI 95% 1.067–1.171) and non-0 blood group (2.574, CI 95% 1.207–5.490) were independent predictors of cardiac injury in hypertensive patients with covid-19. D-dimer (1.082, CI 95% 1.027–1.140), Interleukin-6 (1.216, CI 95% 1.082–1.367) and non-0 blood group (3.706, CI 95% 1.223–11.235) were independent predictors of deaths events in hypertensive patients with covid-19. CONCLUSIONS: Taken together, our data indicate that non-0 covid-19 hypertensive patients have significantly higher values of pro-thrombotic indexes, as well as higher rate of cardiac injury and deaths compared to 0 patients. Moreover, AB0 blood type influences worse prognosis in hypertensive patients with covid-19 infection. url: https://doi.org/10.1186/s12872-020-01658-z doi: 10.1186/s12872-020-01658-z id: cord-308184-w8ewm8ve author: Sarzi-Puttini, Piercarlo title: How to handle patients with autoimmune rheumatic and inflammatory bowel diseases in the COVID-19 era: An expert opinion date: 2020-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: • A correct patient risk stratification is of paramount importance for the proper management of economic and human resources. • It's fundamental to prioritize clinical trials evaluating dosing, prophylaxis, and treatment with immunosuppressant in COVID-19 in order to avoid either an overuse and a treatment shortage. • Future controlled studies may highlight in our patients a potential preventive role of immunosuppressant therapies in the development of severe forms of Covid-19. • Despite the overall risk of infection in rheumatic and gastroenterological diseases a conclusive association between these diseases and COVID −19 remains questionable. url: https://api.elsevier.com/content/article/pii/S1568997220301361 doi: 10.1016/j.autrev.2020.102574 id: cord-274355-6hiutrct author: Satheesan, Manoj Kumar title: A numerical study of ventilation strategies for infection risk mitigation in general inpatient wards date: 2020-02-22 words: 4945.0 sentences: 274.0 pages: flesch: 56.0 cache: ./cache/cord-274355-6hiutrct.txt txt: ./txt/cord-274355-6hiutrct.txt summary: This study investigates the transport mechanism and deposition patterns of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) within a typical six bedded general inpatient ward cubicle through numerical simulation. Although it is widely assumed that increasing the air change rate (ACH) can reduce infection risks, it was shown that the risk of exposure to pathogens could increase with an increased ventilation rate under certain circumstances BUILD SIMUL https://doi.org/10.1007/s12273-020-0623-4 Satheesan et al. As the number of research studies on ventilation systems for general inpatient wards with respect to air change rate and exhaust airflow rate is limited, this study evaluates the combined impacts of these two parameters on the airflow as well as infection risk distributions of droplet nuclei of size 0.167 μm (i.e. MERS-CoV) within an air-conditioned general inpatient ward cubicle. Furthermore, the randomness associated with particle deposition rates (r w , r c , and r f ) under different air change rate conditions can be attributed to the asymmetric airflow distribution patterns and locations of the infected patients. abstract: Aerial dispersion of human exhaled microbial contaminants and subsequent contamination of surfaces is a potential route for infection transmission in hospitals. Most general hospital wards have ventilation systems that drive air and thus contaminants from the patient areas towards the corridors. This study investigates the transport mechanism and deposition patterns of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) within a typical six bedded general inpatient ward cubicle through numerical simulation. It demonstrates that both air change and exhaust airflow rates have significant effects on not only the airflow but also the particle distribution within a mechanically ventilated space. Moreover, the location of an infected patient within the ward cubicle is crucial in determining the extent of infection risk to other ward occupants. Hence, it is recommended to provide exhaust grilles in close proximity to a patient, preferably above each patient’s bed. To achieve infection prevention and control, high exhaust airflow rate is also suggested. Regardless of the ventilation design, all patients and any surfaces within a ward cubicle should be regularly and thoroughly cleaned and disinfected to remove microbial contamination. The outcome of this study can serve as a source of reference for hospital management to better ventilation design strategies for mitigating the risk of infection. url: https://doi.org/10.1007/s12273-020-0623-4 doi: 10.1007/s12273-020-0623-4 id: cord-342786-dl8vjwfn author: Sattar, Yasar title: COVID-19 Cardiovascular Epidemiology, Cellular Pathogenesis, Clinical Manifestations and Management date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Coronavirus Disease 2019 (COVID-19) is a rapidly progressing global pandemic that may present with a variety of cardiac manifestations including, but not limited to, myocardial injury, myocardial infarction, arrhythmias, heart failure, cardiomyopathy, shock, thromboembolism, and cardiac arrest. These cardiovascular effects are worse in patients who have pre-existing cardiac conditions such as coronary artery disease, hypertension, diabetes mellitus, and coagulation abnormalities. Other predisposing risk factors include advanced age, immunocompromised state, and underlying systemic inflammatory conditions. Here we review the cellular pathophysiology, clinical manifestations and treatment modalities of the cardiac manifestations seen in patients with COVID-19. url: https://api.elsevier.com/content/article/pii/S2352906720302876 doi: 10.1016/j.ijcha.2020.100589 id: cord-262780-ilu5oskk author: Sattui, Sebastian E. title: Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19 date: 2020-08-11 words: 4653.0 sentences: 251.0 pages: flesch: 48.0 cache: ./cache/cord-262780-ilu5oskk.txt txt: ./txt/cord-262780-ilu5oskk.txt summary: The use of chloroquine (CQ) and hydroxychloroquine (HCQ) for COVID-19 exemplifies the risks of both overinterpreting and amplifying preliminary data by those outside of the scientific community and was followed by swift corrective measures by researchers. By early March, interest in HCQ abruptly transitioned from mechanistic plausibility that would support its study in a clinical trial setting to rapid off-label use in patients with COVID-19, primarily fueled by promotion on social media, lay press, and celebrity influence [8] . By late March, two new studies became publicly available: a second study from the group of IHU-Méditerranée Infection using HCQ and AZM in 80 patients with mild COVID-19 infection released on their webpage, and a preprint of the first randomized controlled trial of 62 patients from Wuhan reporting a difference in clinical time to recovery and radiologic findings with HCQ treatment [22, 23] . abstract: INTRODUCTION: Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public. AREAS COVERED: We critically assessed major events from February – May 2020 that contributed to widespread use of hydroxychloroquine for the treatment and prophylaxis of COVID-19. We aimed to explore how opinions toward hydroxychloroquine may shift from early enthusiasm (based on in vitro and preliminary clinical data) to the hope for a miracle cure (through communication and promotion of questionable results) and, finally, to a rise of skepticism as more in-depth analyses are emerging. EXPERT OPINION: Mindful and rigorous acquisition of data, as well as its interpretation, are essential to an effective pandemic response. The rapid and premature promotion of results has had major implications for global crisis management, even creating distrust among the public. It is crucial for the medical and scientific community to incorporate the lessons learned from this situation. url: https://doi.org/10.1080/1744666x.2020.1792778 doi: 10.1080/1744666x.2020.1792778 id: cord-004636-t6qldq3s author: Saugel, Bernd title: Journal of Clinical Monitoring and Computing end of year summary 2019: hemodynamic monitoring and management date: 2020-03-14 words: 10306.0 sentences: 479.0 pages: flesch: 42.0 cache: ./cache/cord-004636-t6qldq3s.txt txt: ./txt/cord-004636-t6qldq3s.txt summary: In the original data set, 8.8% of the intraoperative MAP measurements were > 100 mmHg and 4.3% were < 55 mmHg. After automated and manual correction 7.3% (automated) or 7.3% (manual) of MAP measurements were > 100 mmHg and 2.0% (automated) or 2.1% (manual) were < 55 mmHg. The authors discuss potential limitations of the proposed algorithm during episodes with high blood pressure variability as it may be difficult to distinguish real variation from artifacts. The authors included 2273 cases with intra-arterial blood pressure measurements and analyzed changes in intraoperative SAP in four different age groups. In a pilot study, Pybus [38] investigated the feasibility of performing real-time spectral analyses of the respiratory and arterial pressure waveform in 60 cardiac surgical patients and assessed the clinical utility of this technique to predict fluid responsiveness. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080677/ doi: 10.1007/s10877-020-00496-w id: cord-324041-lqokztor author: Saussez, Sven title: Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered date: 2020-09-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: From the start of the pandemic, many European otolaryngologists observed an unprecendented number of anosmic patients. Early reports proposed that anosmia could be the first or even the only symptom of COVID-19 infection, prompting calls for self-isolation in affected patients. METHODS: In the present article, we review the COVID-19 anosmia literature and try to answer the following two questions: first, why is COVID-19 infection responsible for such a high incidence of anosmia? Second, in patients with more severe forms is anosmia really less prevalent and why? RESULTS: In terms of the etiology of olfactory dysfunction, several hypotheses were proposed at the outset of the pandemic; that olfactory cleft inflammation and obstruction caused a localized conductive loss, that there was injury to the sustentacular supporting cells in the olfactory epithelium or, given the known neurotropic potential of coronavirus, that the virus could invade and damage the olfactory bulb. Olfactory cleft obstruction may contribute to the olfactory dysfunction in some patients, perhaps most likely in those that show very early resolution, it cannot account for the loss in all patients. Moreover, disordered regrowth and a predominance of immature neurons have been shown to be associated with parosmia, which is a common finding amongst patients with Covid-related anosmia. A central mechanism therefore certainly seems to be consistent with the group of patients with more prolonged olfactory deficits. Sustentacular cells showing ACE-2 immunohistochemical expression 200 to 700 times greater than nasal or tracheal epithelia seem to be the main SARS-CoV-2 gateway. As the pathophysiology of COVID-19 anosmia seems to be better understood, the question of why patients with a moderate to severe form of COVID-19 infection have less olfactory involvement remains unresolved. Different potential explanations are discussed in this review. CONCLUSIONS: The last 5 months have benefited from great international collaborative research, first highlighting and then proving the value of loss of smell and taste as a symptom of COVID-19. Adoption of loss of smell into the case definition by international public health bodies will facilitate control of disease transmission. url: https://www.ncbi.nlm.nih.gov/pubmed/32909060/ doi: 10.1007/s00405-020-06285-0 id: cord-102276-0a8hup5y author: Savage, R. S. title: Development and validation of multivariable machine learning algorithms to predict risk of cancer in symptomatic patients referred urgently from primary care date: 2020-10-27 words: 3792.0 sentences: 227.0 pages: flesch: 57.0 cache: ./cache/cord-102276-0a8hup5y.txt txt: ./txt/cord-102276-0a8hup5y.txt summary: title: Development and validation of multivariable machine learning algorithms to predict risk of cancer in symptomatic patients referred urgently from primary care In use-case 1, the algorithms correctly identify 20% of patients who do not have cancer and may not need an urgent 2WW referral. 10 We report the development and validation of a set of machine learning algorithms to provide a calibrated risk probability of cancer (a score between zero and one, higher values indicating greater risk of cancer) for triaging symptomatic patients. Table 6 shows test performance characteristics for use-case 2 (triage), to identify patients at higher risk of cancer who would be considered for priority through the urgent referral pathway. This paper reports the development and validation of a set of statistical machine learning algorithms based on routine laboratory blood measurements that can predict cancer outcomes for symptomatic patients referred urgently from primary care for possible cancer diagnosis. abstract: Background: Urgent Suspected Cancer (2WW) referrals have been successful in improving early cancer detection but are increasingly a major burden on NHS services. This has been exacerbated by the COVID-19 pandemic. Method: We developed and validated tests to assess the risk of any cancer for 2WW patients. The tests use routine blood measurements (FBC, U&E, LFTs, tumour markers), combining them using machine learning and statistical modelling. Algorithms were developed and validated for nine 2WW pathways using retrospective data from 371,799 referrals to Leeds Teaching Hospitals Trust (development set 2011-16, validation set 2017-19). A minimum set of blood measurements were required for inclusion, and missing data were modelled internally by the algorithms. Findings: We present results for two clinical use-cases. In use-case 1, the algorithms correctly identify 20% of patients who do not have cancer and may not need an urgent 2WW referral. In use-case 2, they identify 90% of cancer cases with a high probability of cancer that could be prioritised for review. Interpretation: Combining a panel of widely available blood markers produces effective blood tests for cancer for NHS 2WW patients. The tests are cost-effective, can be deployed rapidly to any NHS pathology laboratory with no additional hardware requirements, and are of particular value during the COVID-19 pandemic. url: http://medrxiv.org/cgi/content/short/2020.10.23.20218198v1?rss=1 doi: 10.1101/2020.10.23.20218198 id: cord-013035-7sfj0czv author: Savinelli, Stefano title: Reply date: 2020-09-20 words: 1259.0 sentences: 67.0 pages: flesch: 41.0 cache: ./cache/cord-013035-7sfj0czv.txt txt: ./txt/cord-013035-7sfj0czv.txt summary: We read with great interest the article by McCarthy et al., 1 regarding the favourable use of tocilizumab in a series of patients presenting with cytokine storm related to coronavirus disease 2019 (COVID-19) infection. Reducing short-term mortality from cytokine release syndrome may come at the expense of long-term fatality rate, due to secondary healthcare or ventilator-associated bacterial or fungal infections, especially in critically ill patients with increased length of hospitalization in intensive care units (ICU). However, observational studies demonstrate favourable outcomes regarding mortality and risk of proceeding to endotracheal intubation when IL-6RA are used in a pre-critical (pre-intensive care unit (ICU)) setting, such as that described in our report, before the onset of severe respiratory failure. To address these questions, our group has designed a phase 2, open-label, two-stage, multicentre, randomized trial comparing different doses of single-dose administration of tocilizumab in adults with severe, non-critical, COVID-19 with evidence of hyperinflammatory state. abstract: See related letter url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536901/ doi: 10.1111/resp.13940 id: cord-012025-faj682bp author: Savioli, Felicio title: Coagulation profile in severe COVID-19 patients: what do we know so far? date: 2020 words: 810.0 sentences: 62.0 pages: flesch: 38.0 cache: ./cache/cord-012025-faj682bp.txt txt: ./txt/cord-012025-faj682bp.txt summary: (7) assessed the coagulation profile and outcomes of 449 severe COVID-19 patients. (8) Moreover, a negative D-dimer test could be used for decision-making on anticoagulation therapy discontinuation in venous thromboembolism patients, however, this approach remains arguable and additional studies are required to validate this proposal. (10) The diagnosis of DIC in critically ill patients is made by standard coagulation tests, which can only determine a 5% of thrombin generation and are not suitable to discriminate patients with prothrombotic states from those with increased risk of bleeding. For the present time, we suggest that additional studies should be performed focusing on coagulation testing, to provide a better understanding of the coagulation profile in severe COVID-19 patients, improve the assessment of coagulation-related risks, and support decisions on the appropriated anticoagulation therapy. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405742/ doi: 10.5935/0103-507x.20200031 id: cord-316003-xt59voyt author: Say, Daphne S. title: Risk Stratification and Personal Protective Equipment Use in Pediatric Endoscopy During the Coronavirus Disease 2019 Outbreak: A Single-center Protocol date: 2020-03-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SARS-CoV-2, the novel coronavirus causing coronavirus disease 2019 (COVID-19), is now a global pandemic. Human-to-human transmission has been documented to occur through respiratory secretions, feces, aerosols, and contaminated environmental surfaces. Pediatric patients present a unique challenge as they may have minimal symptoms and yet transmit disease. Endoscopists face risk for infection with viruses like SARS-CoV-2, as the aerosol generating nature of endoscopy diffuses respiratory disease that can be spread via an airborne and droplet route. We describe our center's methodology for pediatric patient risk stratification to facilitate responsible use of endoscopic resources during this crisis. We also describe our recommendations for use of personal protective equipment by endoscopists, with the goal of ensuring the safety of ourselves, our anesthesiology and endoscopy staff, and our patients. url: https://doi.org/10.1097/mpg.0000000000002731 doi: 10.1097/mpg.0000000000002731 id: cord-347375-5ucemm87 author: Sazzad, Hossain M.S. title: Nipah Virus Infection Outbreak with Nosocomial and Corpse-to-Human Transmission, Bangladesh date: 2013-02-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Active Nipah virus encephalitis surveillance identified an encephalitis cluster and sporadic cases in Faridpur, Bangladesh, in January 2010. We identified 16 case-patients; 14 of these patients died. For 1 case-patient, the only known exposure was hugging a deceased patient with a probable case, while another case-patient’s exposure involved preparing the same corpse for burial by removing oral secretions and anogenital excreta with a cloth and bare hands. Among 7 persons with confirmed sporadic cases, 6 died, including a physician who had physically examined encephalitis patients without gloves or a mask. Nipah virus–infected patients were more likely than community-based controls to report drinking raw date palm sap and to have had physical contact with an encephalitis patient (29% vs. 4%, matched odds ratio undefined). Efforts to prevent transmission should focus on reducing caregivers’ exposure to infected patients’ bodily secretions during care and traditional burial practices. url: https://doi.org/10.3201/eid1902.120971 doi: 10.3201/eid1902.120971 id: cord-339737-7qdjea6f author: Sbidian, E. title: Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective To assess the clinical effectiveness of oral hydroxychloroquine (HCQ) with or without azithromycin (AZI) in preventing death or leading to hospital discharge. Design Retrospective cohort study. Setting An analysis of data from electronic medical records and administrative claim data from the French Assistance Publique - Hopitaux de Paris (AP-HP) data warehouse, in 39 public hospitals, Ile-de-France, France. Participants All adult inpatients with at least one PCR-documented SARS-CoV-2 RNA from a nasopharyngeal sample between February 1st, 2020 and April 6th, 2020 were eligible for analysis. The study population was restricted to patients who did not receive COVID-19 treatments assessed in ongoing trials, including antivirals and immunosuppressive drugs. End of follow-up was defined as the date of death, discharge home, day 28 after admission, whichever occurred first, or administrative censoring on May 4, 2020. Intervention Patients were further classified into 3 groups: (i) receiving HCQ alone, (ii) receiving HCQ together with AZI, and (iii) receiving neither HCQ nor AZI. Exposure to a HCQ/AZI combination was defined as a simultaneous prescription of the 2 treatments (more or less one day). Main outcome measures The primary outcome was all-cause 28-day mortality as a time-to-event endpoint under a competing risks survival analysis framework. The secondary outcome was 28-day discharge home. Augmented inverse probability of treatment weighted (AIPTW) estimates of the average treatment effect (ATE) were computed to account for confounding. Results A total of 4,642 patients (mean age: 66.1 +/- 18; males: 2,738 (59%)) were included, of whom 623 (13.4%) received HCQ alone, 227 (5.9%) received HCQ plus AZI, and 3,792 (81.7%) neither drug. Patients receiving "HCQ alone" or "HCQ plus AZI" were more likely younger, males, current smokers and overall presented with slightly more co-morbidities (obesity, diabetes, any chronic pulmonary diseases, liver diseases), while no major difference was apparent in biological parameters. After accounting for confounding, no statistically significant difference was observed between the "HCQ" and "Neither drug" groups for 28-day mortality: AIPTW absolute difference in ATE was +1.24% (-5.63 to 8.12), ratio in ATE 1.05 (0.77 to 1.33). 28-day discharge rates were statistically significantly higher in the "HCQ" group: AIPTW absolute difference in ATE (+11.1% [3.30 to 18.9]), ratio in ATE (1.25 [1.07 to 1.42]). As for the "HCQ+AZI" vs neither drug, trends for significant differences and ratios in AIPTW ATE were found suggesting higher mortality rates in the former group (difference in ATE +9.83% [-0.51 to 20.17], ratio in ATE 1.40 [0.98 to 1.81];p=0.062). Conclusions Using a large non-selected population of inpatients hospitalized for COVID-19 infection in 39 hospitals in France and robust methodological approaches, we found no evidence for efficacy of HCQ or HCQ combined with AZI on 28-day mortality. Our results suggested a possible excess risk of mortality associated with HCQ combined with AZI, but not with HCQ alone. Significantly higher rates of discharge home were observed in patients treated by HCQ, a novel finding warranting further confirmation in replicative studies. Altogether, our findings further support the need to complete currently undergoing randomized clinical trials. url: https://doi.org/10.1101/2020.06.16.20132597 doi: 10.1101/2020.06.16.20132597 id: cord-266512-xh6zed03 author: Scala, Enrico title: Atopic statusprotects from severe complications of COVID‐19 date: 2020-08-16 words: 1297.0 sentences: 70.0 pages: flesch: 44.0 cache: ./cache/cord-266512-xh6zed03.txt txt: ./txt/cord-266512-xh6zed03.txt summary: In infection, the Th2 response counteractsthe microbicidal Th1 response, which could limit the tissue damage induced by Th1-mediated inflammation (4) on one hand, but also cause a less efficient anti-virus response, as shown in a study on experimental Coronavirus 229E infection in healthy volunteers, where atopy appeared to be associated with a more severe rhinitis score (5) .Further, atopic subjects show a reduced expression of ACE2, the SARS-CoV-2 receptor, which could be associated with reduced susceptibility to the virus (6) . The multiple logistic regression analysis(details in supplementary material) confirmed a significant association between atopic status andmilder COVID-19;non-atopic patients had a significantly higher risk of having severe Covid-19 (OR adj 3.0, 95% CI 1.6-5.7, p =0.001) ( Table 1) In severe SARS-CoV-2 infection hyper-expressed cytokines include IFN-gamma, TNF-alpha, and IL-6, which cause fever, fatigue, flu-like symptoms, vascular leakage due to endothelial dysfunction, cardiomyopathy, hypotension, lung injury, activation of the coagulation cascade, and diffuse intravascular coagulation (7) . abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32799364/ doi: 10.1111/all.14551 id: cord-313227-6zwkfzab author: Scala, Stefania title: Fighting the Host Reaction to SARS-COv-2 in Critically Ill Patients: The Possible Contribution of Off-Label Drugs date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-COv-2) is the etiologic agent of the 2019 coronavirus disease (COVID19). The majority of infected people presents flu like symptoms and among them 15–20% develops a severe interstitial pneumonitis (IP) that may eventually evolve in acute respiratory distress syndrome (ARDS). IP is caused by the viral glycoprotein spike (S) binding to the angiotensin converting enzyme 2 (ACE2) expressed on the surface of alveolar pneumocytes. The virus is recognized by the “pattern recognition receptors” (PRR) of the immune cells that release cytokines activating more immune cells that produce a large number of pro-inflammatory cytokines, tissue factors and vasoactive peptides. Affected patients might develop the “cytokine storm syndrome,” a fulminant and fatal hypercytokinaemia with multiorgan failure. In patients infected by SARS-COv-2 increase in T-helper 2 (TH2) cytokines (IL-4 and IL10) are reported in addition to the T-helper 1 (TH1) cytokines (IL1B, IFNγ, IP10, and MCP1) previously detected in other coronavirus infections. Cytokines and other molecules involved in immune response and inflammation are conceivable therapeutic targets for IP and ARDS, improving symptoms and decreasing intensive care unit admissions. To this aim off label drugs may be used taking into consideration the window timing for immunosuppressive drugs in virus infected patients. Some off label therapeutic options and preclinical evidence drugs are herein considered. url: https://www.ncbi.nlm.nih.gov/pubmed/32574268/ doi: 10.3389/fimmu.2020.01201 id: cord-312012-6a7i72bk author: Scalea, Joseph R. title: The Distancing of Surgeon From Patient in the Era of COVID-19: Bring on the Innovation date: 2020-04-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1097/sla.0000000000003962 doi: 10.1097/sla.0000000000003962 id: cord-252506-8u9oiqoc author: Scarfò, Lydia title: COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus date: 2020-07-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (≥65 years) (odds ratio 3.72 [95% CI 1.79–7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (≤12 months) treatment for CLL at the time of COVID-19 versus 30/39 (76.9%) patients with mild disease. Hospitalization rate for severe COVID-19 was lower (p < 0.05) for patients on ibrutinib versus those on other regimens or off treatment. Of 151 patients with severe disease, 55 (36.4%) succumbed versus only 1/38 (2.6%) with mild disease; age and comorbidities did not impact on mortality. In CLL, (1) COVID-19 severity increases with age; (2) antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; (3) age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency. url: https://doi.org/10.1038/s41375-020-0959-x doi: 10.1038/s41375-020-0959-x id: cord-293333-mqoml9o5 author: Scharbarg, Emeric title: From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves date: 2020-10-03 words: 5785.0 sentences: 330.0 pages: flesch: 59.0 cache: ./cache/cord-293333-mqoml9o5.txt txt: ./txt/cord-293333-mqoml9o5.txt summary: The second local model refers to a single node of the health system network, i.e. it models the flows of patients with a smaller granularity at the level of a regional hospital care center for COVID-19 infected patients. In particular apart the high transmission rate, other two aspects were immediately pointed out by the physicians which did strongly influence the diffusion of the disease and the medical resources: first it was estimated that a large delay of time (10 to 14 days) is present between the moment in which a person becomes infected and can infect, and the instant in which symptoms become evident and the person is isolated and sent to quarantine. The subsystem (2) consisting by I q , R and D q is then further discussed in Section 4: a group of people who are aware of their infection define the flow of admissions in a local hospital and are split into two populations, the patients admitted in conventional hospitalization and the patients admitted in intensive care. abstract: Two mathematical models of the COVID-19 dynamics are considered as the health system in some country consists in a network of regional hospital centers. The first macroscopic model for the virus dynamics at the level of the general population of the country is derived from a standard SIR model. The second local model refers to a single node of the health system network, i.e. it models the flows of patients with a smaller granularity at the level of a regional hospital care center for COVID-19 infected patients. Daily (low cost) data are easily collected at this level, and are worked out for a fast evaluation of the local health status thanks to control systems methods. Precisely, the identifiability of the parameters of the hospital model is proven and thanks to the availability of clinical data, essential characteristics of the local health status are identified. Those parameters are meaningful not only to alert on some increase of the infection, but also to assess the efficiency of the therapy and health policy. url: https://www.ncbi.nlm.nih.gov/pubmed/33041632/ doi: 10.1016/j.arcontrol.2020.09.007 id: cord-034371-j3xxmkjd author: Schellack, Natalie title: COVID-19: Guidelines for pharmacists in South Africa date: 2020-06-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Epidemiology. The virus, its modes of transmission and incubation period. Symptom identification, including the differentiation between influenza, allergic rhinitis, sinusitis and COVID-19. Social media myths and misinformation. Treatment guidelines and medicines that may need to be kept in stock. Treatment and prevention options, including an update on vaccine development. The case for and against the use of NSAIDs, ACE-inhibitors and angiotensin receptor blockers (ARBs) in patients with COVID-19. Interventions and patient counselling by the pharmacist. World Health Organization (WHO): https://www.who.int/emergencies/diseases/novel-coronavirus-2019. National Institute for Communicable Diseases (NICD): https://www.nicd.ac.za/diseases-a-z-index/covid-19/. National Department of Health (NDoH): http://www.health.gov.za/index.php/outbreaks/145-corona-virus-outbreak/465-corona-virus-outbreak; https://sacoronavirus.co.za/; url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577345/ doi: 10.4102/sajid.v35i1.206 id: cord-024120-3eemj37r author: Schiff, Gordon D. title: An Interview with Gordon D. Schiff date: 2020-04-29 words: 5175.0 sentences: 267.0 pages: flesch: 49.0 cache: ./cache/cord-024120-3eemj37r.txt txt: ./txt/cord-024120-3eemj37r.txt summary: [10] [11] [12] I also worked on early efforts to leverage health information technology (IT) by linking lab and pharmacy data, 13, 14 demonstrate the value of integrating drug indication into computerized physician order entry (CPOE), 15 identify safety vulnerabilities in current CPOE systems, 16, 17 and conceptualize ways redesigning electronic clinical documentation redesign could prevent diagnostic errors. I believe we have squandered much of its potential to help us achieve the World Health Organization (WHO) Global Patient Safety Challenge aim of "Medication without Harm." 26 These areas of failure include poorly designed decision support, introduction of new types of errors associated with using CPOE systems, frustratingly inefficient work-flows and screens that lead to dangerous workarounds, suboptimal linkages between prescribing systems and pharmacy dispensing databases resulting in prescribers not knowing what drugs have actually been dispensed by pharmacies and pharmacies not knowing when drugs are discontinued by physicians, inadequate monitoring of patients prescribed medications (including adverse effects and adherence), and failure of prescribing systems to help prescribers know the drug-of-choice for a particular indication. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189185/ doi: 10.1016/j.jcjq.2020.04.008 id: cord-281130-9tawihti author: Schirinzi, Annalisa title: Pentraxin 3: Potential prognostic role in SARS-CoV-2 patients admitted to the emergency department date: 2020-11-02 words: 1037.0 sentences: 58.0 pages: flesch: 49.0 cache: ./cache/cord-281130-9tawihti.txt txt: ./txt/cord-281130-9tawihti.txt summary: (4) that evaluated the role of complement related pattern recognition molecules, including C-reactive protein (CRP) and Pentraxin 3 (PTX3), as markers of short-term mortality in intensive care patients. In order to evaluate the potential prognostic value of PTX3 and its correlation with the severity of SARS-CoV-2, measurement of PTX3 in serum samples of patients (n= 75, male/female 47/28, age 69 years (median) 59-75 years (IQR)) with COVID-19 microbiology proven infection (from March to May 2020) was carried out using an enzyme-linked immunosorbent assay (ELISA) (DSX, Technogenetics srl, Milano, Italy), in addition to routine laboratory tests performed at admission. Moreover, PTX3 correlated (Spearman test) with some inflammation biochemical parameters commonly evaluated in SARS-CoV-2 patients, in particular with IL-6 (r =0.69, p<0.001), PCT (r =0.52, p<0.001), PSP (r =0.52, p<0.001), LDH (r =0.62, p<0.001), CRP (r =0.59, p<0.001), and D-dimer (r =0.43, p<0.001). Taken together, data obtained from our preliminary study suggest a potential prognostic role of PTX3 in SARS-CoV-2 patients, with higher levels associated with poor outcome. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33147434/ doi: 10.1016/j.jinf.2020.10.027 id: cord-294057-fbox3a5q author: Schlegl, Sandra title: Bulimia nervosa in times of the COVID‐19 pandemic—Results from an online survey of former inpatients date: 2020-08-07 words: 2812.0 sentences: 149.0 pages: flesch: 53.0 cache: ./cache/cord-294057-fbox3a5q.txt txt: ./txt/cord-294057-fbox3a5q.txt summary: It was divided into seven parts: (a) Sociodemographic and other information such as age, sex, current self-reported height and weight, occupational situation during the COVID-19 pandemic, and contact history with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that is, current or previous own confirmed infection or infection of others (yes/no answers); (b) Overall impact of the COVID-19 pandemic on ED symptoms and general well-being, that is, deterioration of symptomatology and quality of life, adverse effects on therapy, incidence of new symptoms (5-point scale with 1 = strongly agree to 5 = strongly disagree); (c) Worries, for example, regarding infections, relapses, food insecurity, finances, and job (5-point scale with 1 = extremely worried to 5 = not at all worried); (d) General psychopathology and interpersonal conflicts (5-point scale with 1 = significantly worsened to 5 = significantly improved); (e) Specific ED symptoms and behaviours (5-point scale from 1 = significantly worsened/much more to 5 = significantly improved/much less); (f) Health care utilisation before and during the COVID-19 pandemic (yes/no answers); (g) Use and helpfulness of strategies as suggested by Fernandez-Aranda et al. abstract: OBJECTIVE: The COVID‐19 pandemic might pose special challenges to patients with eating disorders (EDs) by interfering with daily routines. The aim of this study was to investigate the impact of the current pandemic on patients with bulimia nervosa (BN). METHODS: Fifty‐five former inpatients with BN completed an online survey on psychological consequences of the COVID‐19 pandemic as well as on changes in health care utilisation and on the use and helpfulness of different coping strategies. RESULTS: Almost half of patients (49%) reported a deterioration of their ED symptomatology and 62% reported a reduced quality of life. The frequency of binge eating increased in 47% of patients and self‐induced vomiting in 36%. Forty‐six percent of patients stated a noticeable impairment of psychotherapy. Face‐to‐face psychotherapy decreased by 56% but videoconferencing therapy was only used by 22% of patients. Enjoyable activities, virtual social contacts with friends and mild physical activities were rated as the most helpful coping strategies among those most used. DISCUSSION: Approximately one half to two‐thirds of former inpatients with BN experienced a negative impact of the crisis on their ED symptomatology and quality of life. In challenging times when face‐to‐face therapy options are restricted, e‐health treatments such as videoconferencing therapy should be considered to ensure continuity of care. url: https://doi.org/10.1002/erv.2773 doi: 10.1002/erv.2773 id: cord-278332-fbksw3om author: Schlick, Cary Jo R. title: Adequate Lymphadenectomy as a Quality Measure in Esophageal Cancer: Is there an Association with Treatment Approach? date: 2020-06-09 words: 3945.0 sentences: 216.0 pages: flesch: 40.0 cache: ./cache/cord-278332-fbksw3om.txt txt: ./txt/cord-278332-fbksw3om.txt summary: As such, analyses of the impact of quality measure adherence on overall survival in esophageal cancer have relied on the NCCN definition of at least 15 lymph nodes for adequate lymphadenectomy, regardless of the use of neoadjuvant therapy. Thus, the objectives of this study were to (1) explore trends in adequate lymphadenectomy rates over time; (2) evaluate unadjusted lymphadenectomy yield in esophageal cancer based on treatment characteristics; and (3) identify independent factors associated with adequate lymphadenectomy. Considering this finding in light of the fact that many patients do not achieve adequate lymphadenectomy, we argue that the oncologic community should accept a generalized lymphadenectomy threshold regardless of the therapeutic approach, and instead focus on modifiable With regard to surgical approach, we found an increased number of examined lymph nodes with laparoscopic and robotic surgery in comparison with the open approach. However, a focus on surgical approach and esophagectomy volume, which are modifiable factors associated with adequate lymphadenectomy, may promote continuous quality improvement in esophageal cancer care. abstract: BACKGROUND: The national comprehensive cancer network defines adequate lymphadenectomy as evaluation of ≥ 15 lymph nodes in esophageal cancer. However, varying thresholds have been suggested following neoadjuvant therapy. OBJECTIVES: Our objectives were to (1) explore trends in adequate lymphadenectomy rates over time; (2) evaluate unadjusted lymphadenectomy yield by treatment characteristics; and (3) identify independent factors associated with adequate lymphadenectomy. METHODS: The National Cancer Data Base was used to identify patients who underwent esophagectomy for cancer from 2004 to 2015. Adequate lymphadenectomy trends over time were evaluated using the Cochrane–Armitage test, and lymph node yield by treatment approach was compared using the Mann–Whitney U and Kruskal–Wallis tests. Associations with treatment factors were assessed by multivariable logistic regression. RESULTS: Among 24,413 patients, 9919 (40.6%) had adequate lymphadenectomy. Meeting the nodal threshold increased over time (52.6% in 2015 vs. 26.0% in 2004; p < 0.01). Lymph node yield did not differ based on neoadjuvant therapy (median 12 [interquartile range 7–19] with and without neoadjuvant therapy; p = 0.44). Adequate lymphadenectomy was not associated with neoadjuvant therapy (40.5% vs. 40.8%, odds ratio [OR] 0.94, 95% confidence interval [CI] 0.82–1.07), but was associated with surgical approach (52.7% of laparoscopic cases, OR 1.28, 95% CI 1.06–1.56; 61.2% of robotic cases, OR 1.71, 95% CI 1.34–2.19, vs. 43.5% of open cases), and increasing annual esophagectomy volume (55.6% in the fourth quartile vs. 32.6% in the first quartile; OR 3.57, 95% CI 2.35–5.43). CONCLUSIONS: Despite increases over time, only 50% of patients undergo adequate lymphadenectomy during esophageal cancer resection. Adequate lymphadenectomy was not associated with neoadjuvant therapy. Focusing on surgical approach and esophagectomy volume may further improve adequate lymphadenectomy rates. url: https://www.ncbi.nlm.nih.gov/pubmed/32519142/ doi: 10.1245/s10434-020-08578-4 id: cord-321149-hffj7s4o author: Schmidt, Matthieu title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Summary Background Patients with COVID-19 who develop severe acute respiratory distress syndrome (ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and death. The efficacy of extracorporeal membrane oxygenation (ECMO) for patients with severe ARDS in the context of COVID-19 is unclear. We aimed to establish the clinical characteristics and outcomes of patients with respiratory failure and COVID-19 treated with ECMO. Methods This retrospective cohort study was done in the Paris–Sorbonne University Hospital Network, comprising five intensive care units (ICUs) and included patients who received ECMO for COVID-19 associated ARDS. Patient demographics and daily pre-ECMO and on-ECMO data and outcomes were collected. Possible outcomes over time were categorised into four different states (states 1–4): on ECMO, in the ICU and weaned off ECMO, alive and out of ICU, or death. Daily probabilities of occupation in each state and of transitions between these states until day 90 post-ECMO onset were estimated with use of a multi-state Cox model stratified for each possible transition. Follow-up was right-censored on July 10, 2020. Findings From March 8 to May 2, 2020, 492 patients with COVID-19 were treated in our ICUs. Complete day-60 follow-up was available for 83 patients (median age 49 [IQR 41–56] years and 61 [73%] men) who received ECMO. Pre-ECMO, 78 (94%) patients had been prone-positioned; their median driving pressure was 18 (IQR 16–21) cm H2O and PaO2/FiO2 was 60 (54–68) mm Hg. At 60 days post-ECMO initiation, the estimated probabilities of occupation in each state were 6% (95% CI 3–14) for state 1, 18% (11–28) for state 2, 45% (35–56) for state 3, and 31% (22–42) for state 4. 35 (42%) patients had major bleeding and four (5%) had a haemorrhagic stroke. 30 patients died. Interpretation The estimated 60-day survival of ECMO-rescued patients with COVID-19 was similar to that of studies published in the past 2 years on ECMO for severe ARDS. If another COVID-19 outbreak occurs, ECMO should be considered for patients developing refractory respiratory failure despite optimised care. Funding None. url: https://www.ncbi.nlm.nih.gov/pubmed/32798468/ doi: 10.1016/s2213-2600(20)30328-3 id: cord-019027-6chba2ru author: Schmidt, Michael G. title: Role of the Microbial Burden in the Acquisition and Control of Healthcare Associated Infections: The Utility of Solid Copper Surfaces date: 2014-07-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: For more than a century, healthcare has been challenged to keep environmental surfaces clean to control microbes and improve patient outcomes. However despite an annual cost exceeding ten billion dollars cleaning with disinfection has done little to reduce the incidence of healthcare-associated infections (HAI). This chapter will review the scientific evidence delineating the role that the environment and healthcare workers play in the acquisition and movement of the microbes implicated in HAI and how through controlling the microbial burden of the built clinical environment it is possible to mitigate the rate of HAI acquisition. Specifically evidence demonstrating the effectiveness of solid copper surfaces for its ability to continuously limit the concentration of bacteria found on surfaces and objects within the built environment will be reviewed in concert with a discussion of how through the mitigation of the environmental burden copper surfaces are able to concomitantly reduce the incidence of HAI. Insights provided by this chapter are intended to facilitate an understanding and importance of the need to use a comprehensive or systems based approach to fight healthcare associated infections. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124072/ doi: 10.1007/978-3-319-08057-4_4 id: cord-351046-yq7287k9 author: Schubert, Gena title: How Much Drool Is Too Much?() date: 2019-12-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A 3-year-old boy presented to the emergency department with a chief complaint of “lethargy” and was found to have ptosis with eventual respiratory failure and need for emergent intubation. There is a broad differential for a patient with respiratory failure, and careful physical examination and history are imperative to reduce morbidity and prevent mortality. After further evaluation and workup, the diagnosis is ultimately revealed. url: https://api.elsevier.com/content/article/pii/S1522840119300989 doi: 10.1016/j.cpem.2019.100742 id: cord-319615-p2labgd8 author: Schulman, Sam title: Coronavirus Disease 2019, Prothrombotic Factors, and Venous Thromboembolism date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1055/s-0040-1710337 doi: 10.1055/s-0040-1710337 id: cord-347905-w0fnc43a author: Schwartz, Joseph S. title: Diseases of the nasal cavity date: 2019-10-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Despite garnering minimal attention from the medical community overall, olfaction is indisputably critical in the manner in which we as humans interact with our surrounding environment. As the initial anatomical structure in the olfactory pathway, the nasal airway plays a crucial role in the transmission and perception of olfactory stimuli. The goal of this chapter is to provide a comprehensive overview of olfactory disturbances as it pertains to the sinonasal airway. This comprises an in-depth discussion of clinically relevant nasal olfactory anatomy and physiology, classification systems of olfactory disturbance, as well as the various etiologies and pathophysiologic mechanisms giving rise to this important disease entity. A systematic clinical approach to the diagnosis and clinical workup of olfactory disturbances is also provided in addition to an extensive review of the medical and surgical therapeutic modalities currently available. url: https://www.sciencedirect.com/science/article/pii/B9780444638557000186 doi: 10.1016/b978-0-444-63855-7.00018-6 id: cord-268168-yzvag38x author: Scolnick, Barbara title: Remission from Chronic Anorexia Nervosa With Ketogenic Diet and Ketamine: Case Report date: 2020-07-30 words: 4653.0 sentences: 243.0 pages: flesch: 53.0 cache: ./cache/cord-268168-yzvag38x.txt txt: ./txt/cord-268168-yzvag38x.txt summary: We report the case of a 29 year-old woman who struggled with severe and enduring anorexia nervosa for 15 years, and experienced a complete recovery following a novel treatment of adopting a ketogenic diet followed by ketamine infusions. CONCLUSIONS: This is the first report of a ketogenic diet used specifically for the treatment of anorexia nervosa, followed by a short series of titrated IV ketamine infusions leading to complete remission of severe and enduring anorexia nervosa, with weight restoration, and sustained cessation of cognitive and behavioral symptoms, for 6 months. Complete and sustained remission of chronic anorexia nervosa is quite rare, and the novel use of a ketogenic diet and IV ketamine treatment in this potentially lethal condition suggests avenues for further research, and hope for patients and their families. We report a case of severe and chronic AN treated successfully by adopting a ketogenic (KG) diet for 3 months followed by a series of intravenous ketamine infusions. abstract: BACKGROUND: Chronic anorexia nervosa is a tragic disease with no known effective pharmacological or behavioral treatment. We report the case of a 29 year-old woman who struggled with severe and enduring anorexia nervosa for 15 years, and experienced a complete recovery following a novel treatment of adopting a ketogenic diet followed by ketamine infusions. Her remission has persisted for over 6 months. CASE PRESENTATION: At age 14.5, the patient embarked on an effort to “eat healthy.” She quickly lost control of the dieting, developed associated compulsions and obsessions about food, body dissatisfaction, emotional lability, and lost nearly 13.6 kilograms (30 pounds). She was hospitalized for 6 weeks, and while she regained some weight, she did not attain full weight restoration. For 15 years, she continued to eat in a restrictive manner, exercise compulsively, and have intermittent periods of alcohol dependence. Nevertheless, she always hoped to get well, and at age 29, she began a novel treatment for anorexia nervosa. CONCLUSIONS: This is the first report of a ketogenic diet used specifically for the treatment of anorexia nervosa, followed by a short series of titrated IV ketamine infusions leading to complete remission of severe and enduring anorexia nervosa, with weight restoration, and sustained cessation of cognitive and behavioral symptoms, for 6 months. Although these treatments were used sequentially the relationship between these modalities, and possible synergy, is unclear, and deserves further study. Complete and sustained remission of chronic anorexia nervosa is quite rare, and the novel use of a ketogenic diet and IV ketamine treatment in this potentially lethal condition suggests avenues for further research, and hope for patients and their families. url: https://doi.org/10.3389/fpsyt.2020.00763 doi: 10.3389/fpsyt.2020.00763 id: cord-345762-khvcoqti author: Scott, Ian A. title: COVID‐19 pandemic and the tension between the need to act and the need to know date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1111/imj.14929 doi: 10.1111/imj.14929 id: cord-306266-8qdrshz3 author: Scully, Crispian title: Respiratory medicine date: 2014-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: ●. Upper respiratory infections are commonplace, especially in young people, and are often contagious; ●. Lower respiratory infections are often contagious and some are potentially fatal; ●. Asthma is common and may be life-threatening; ●. Chronic obstructive pulmonary disease is common and disabling; ●. Tuberculosis worldwide is an important infection, affecting people with HIV/AIDS or malnutrition particularly; ●. Lung cancer is common and usually has a poor prognosis. url: https://api.elsevier.com/content/article/pii/B9780702054013000151 doi: 10.1016/b978-0-7020-5401-3.00015-1 id: cord-275979-cx2h5bsw author: Scutelnic, Adrian title: Vascular Events, Vascular Disease and Vascular Risk Factors—Strongly Intertwined with COVID-19 date: 2020-10-08 words: 6747.0 sentences: 342.0 pages: flesch: 46.0 cache: ./cache/cord-275979-cx2h5bsw.txt txt: ./txt/cord-275979-cx2h5bsw.txt summary: According to the INTERSTROKE study, the 10 most frequent modifiable vascular risk factors are arterial hypertension, physical inactivity, overweight, dyslipidaemia, smoking, unhealthy diet, cardiac pathologies, diabetes mellitus, stress/depression and overconsumption of alcohol. Also, a higher rate of infection with COVID-19, severe COVID-19 and bad outcome has been demonstrated in patients with pre-existing vascular disease and vascular risk factors. A higher rate of infection with COVID-19, severe COVID-19, and worse outcome has been demonstrated in patients with pre-existing vascular disease and risk factors, compared with young and healthy persons [1, 6, 8-11, 28, 29] . Several potential mechanisms increasing this risk of COVID-19 in patients with diabetes mellitus have been proposed: (1) higher affinity of cellular binding of SARS-CoV-2 and higher levels of circulating furin facilitating virus entry, (2) increased ACE2 expression in the lungs, (3) decreased viral clearance, (4) diminished T cell function, (5) increased susceptibility to inflammation and cytokine storm syndrome and (6) co-existence of vascular disease and risk factors [5] . abstract: PURPOSE OF REVIEW: To elucidate the intertwining of vascular events, vascular disease and vascular risk factors and COVID-19. RECENT FINDINGS: Strokes are a leading cause of disability and death worldwide. Vascular risk factors are important drivers of strokes. There are unmodifiable vascular risk factors such as age and ethnicity and modifiable vascular risk factors. According to the INTERSTROKE study, the 10 most frequent modifiable vascular risk factors are arterial hypertension, physical inactivity, overweight, dyslipidaemia, smoking, unhealthy diet, cardiac pathologies, diabetes mellitus, stress/depression and overconsumption of alcohol. Also, infection and inflammation have been shown to increase the risk of stroke. There is high-quality evidence for the clinical benefits of optimal primary and secondary stroke prevention. The COVID-19 pandemic brought a new perspective to this field. Vascular events, vascular disease and vascular risk factors—and COVID-19—are strongly intertwined. An increased risk of vascular events—by multifactorial mechanisms—has been observed in COVID-19 patients. Also, a higher rate of infection with COVID-19, severe COVID-19 and bad outcome has been demonstrated in patients with pre-existing vascular disease and vascular risk factors. SUMMARY: At present, we suggest that regular interactions between healthcare professionals and patients should include education on COVID-19 and on primary and secondary vascular prevention in order to reduce the burden of disease in our ageing populations. url: https://doi.org/10.1007/s11940-020-00648-y doi: 10.1007/s11940-020-00648-y id: cord-303460-abutfxtf author: Searle, Tamara title: Screen rhytides: the cosmetic legacy of COVID‐19 date: 2020-08-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1111/dth.14211 doi: 10.1111/dth.14211 id: cord-289219-qjxdggz3 author: Sebio-García, Raquel title: Pulmonary Rehabilitation: Time for an Upgrade date: 2020-08-25 words: 1866.0 sentences: 78.0 pages: flesch: 37.0 cache: ./cache/cord-289219-qjxdggz3.txt txt: ./txt/cord-289219-qjxdggz3.txt summary: Pulmonary rehabilitation is a notoriously known but highly underused intervention aimed to restore or improve functional capacity, symptom management and health-related quality of life among patients with chronic respiratory diseases. Since early 1980s, pulmonary rehabilitation has been acknowledged as a comprehensive intervention with hundreds of studies being performed over the past thirty years demonstrating its benefits on multiple outcomes; nevertheless, there are still multiple unresolved challenges, and new ones are currently emerging, with the COVID-19 outbreak now in the spotlight. PR stems from a comprehensive evaluation of the patient aimed to design an individually-tailored, multi-component intervention to optimise symptom control, pulmonary function, exercise capacity and health-related quality of life [1] . The effectiveness of PR on different outcomes such as exercise capacity, muscle function, dyspnoea and symptom control, is quite robust, so it is currently recommended in the management of different chronic respiratory conditions, especially for patients with chronic obstructive pulmonary disease (COPD). abstract: Pulmonary rehabilitation is a notoriously known but highly underused intervention aimed to restore or improve functional capacity, symptom management and health-related quality of life among patients with chronic respiratory diseases. Since early 1980s, pulmonary rehabilitation has been acknowledged as a comprehensive intervention with hundreds of studies being performed over the past thirty years demonstrating its benefits on multiple outcomes; nevertheless, there are still multiple unresolved challenges, and new ones are currently emerging, with the COVID-19 outbreak now in the spotlight. In this editorial, these issues are summarized and discussed, while presenting some of the latest findings in research and clinical practice, with the ultimate goal of raising awareness of the future of pulmonary rehabilitation in the post COVID-19 era. url: https://www.ncbi.nlm.nih.gov/pubmed/32854317/ doi: 10.3390/jcm9092742 id: cord-284163-3jmqzemf author: Seffer, Malin-Theres title: Heparin 2.0: A New Approach to the Infection Crisis date: 2020-07-02 words: 2982.0 sentences: 156.0 pages: flesch: 43.0 cache: ./cache/cord-284163-3jmqzemf.txt txt: ./txt/cord-284163-3jmqzemf.txt summary: This narrative review will give a brief overview regarding some of the extracorporeal devices that could be used to treat COVID-19 patients, including the Seraph® 100 Microbind® Affinity Blood Filter, produced by ExThera Medical (Martinez, CA, USA), first licensed in the European Economic Area in 2019. Bacteria, viruses, fungi, and toxins have been shown to bind to the immobilized heparin in a similar way to the interaction with heparan sulfate on the cell surface. Of note, it has recently been demonstrated that SARS-CoV-2 attaches to heparin through its surface protein Spike 1 receptor-binding domain [21] . The Seraph ® 100 Microbind ® Affinity Blood Filter is an extracorporeal hemoperfusion device whose functional core, that is, polyethylene beads (diameter of 0.3 mm) with immobilized heparin bound to it, mimics a naturally mammalian cell surface (Fig. 1) . Cytokines in blood from septic patients interact with surface-immobilized heparin abstract: In April 2020, the US Food and Drug Administration granted emergency use authorization for certain medical devices to be used in patients with coronavirus disease 2019 (CO­VID-19). This included extracorporeal blood purification devices. This narrative review will give a brief overview regarding some of the extracorporeal devices that could be used to treat COVID-19 patients, including the Seraph® 100 Microbind® Affinity Blood Filter, produced by ExThera Medical (Martinez, CA, USA), first licensed in the European Economic Area in 2019. The Seraph® 100 contains ultrahigh molecular weight polyethylene beads with end point-attached heparin and is approved for the reduction of pathogens from the bloodstream either as a single agent or as an adjunct to conventional anti-infective agents. Bacteria, viruses, fungi, and toxins have been shown to bind to the immobilized heparin in a similar way to the interaction with heparan sulfate on the cell surface. This binding is nonreversible and as such, the pathogens are removed from the bloodstream. In this review, we describe the pathophysiological basis and rationale for using heparin for pathogen removal from the blood as well as exploring the technology behind the adaptation of heparin to deprive it of its systemic anticoagulant activity. In addition, we summarize the in vitro data as well as the available preclinical testing and published clinical reports. Finally, we discuss the enormous potential of this technology in an era of increasing antibiotic resistance and high mortality associated with sepsis and consider the application of this as a possible treatment option for COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32615569/ doi: 10.1159/000508647 id: cord-295794-glcg36si author: Seghers, Victor J. title: After the initial COVID-19 surge: a phased radiology departmental re-opening plan date: 2020-08-22 words: 4747.0 sentences: 201.0 pages: flesch: 37.0 cache: ./cache/cord-295794-glcg36si.txt txt: ./txt/cord-295794-glcg36si.txt summary: Social distancing, stay home/work safe orders, protective measures for vulnerable individuals (e.g., immunocompromised patients), masking protocols, visitation policies, testing and many more measures resulted in an accelerated but necessary ramping down of elective hospital services [4] [5] [6] [7] [8] [9] . While the radiologist-in-chief also participates in daily meetings with other clinical service chiefs and executive leadership for the hospital, the radiologist-in-chief is an integral member of the systemwide "Phased Recovery and Redesign Team" as well, which includes team captains for infection control, surgery, anesthesia, emergency and urgent care centers, radiology, pathology, ambulatory medicine, specialty care centers, e-health, revenue cycle and billing, and marketing and public relations. This can include patient-directed online scheduling and expanded access to imaging, offering same-day service with hours and locations adapted to the patient and family lifestyle; improved use of virtual dashboards to more easily track various metrics including MR efficiency, sedation utilization, and length of patient stay in the imaging department; and investment in Table 2 Radiology: the opportunity to re-design operations post COVID-19 abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32827259/ doi: 10.1007/s00247-020-04792-0 id: cord-032335-6c9gt7t9 author: Segrelles-Calvo, Gonzalo title: Therapeutic limitation in elderly patients: Reflections regarding COVID19() date: 2020-09-19 words: 1309.0 sentences: 65.0 pages: flesch: 52.0 cache: ./cache/cord-032335-6c9gt7t9.txt txt: ./txt/cord-032335-6c9gt7t9.txt summary: In a recent editorial, published in The New England Journal of Medicine, the authors address the problem of having to choose between 2 or more patients for the assignment of resources, such as ICU admission. This real situation that arose during the Covid-19 pandemic underlines the need to develop fair resource allocation procedures that include all the stakeholders involved in patient care, and the patient and family themselves, in order to develop prioritization criteria for decisionmaking in times of adversity, without transferring this burden to a single healthcare professional in a specific situation. Among the many changes that will emerge after the Covid-19 pandemic, we believe that one of the most relevant will surely be the expansion of RICUs and the leadership of respiratory medicine in decision-making on borderline patients, such as the elderly, unifying selection criteria, clarifying the concept of frailty, and integrating its use into our clinical practice. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501532/ doi: 10.1016/j.arbr.2020.05.008 id: cord-308075-1ftswsm8 author: Segura, Patricia Sanz title: Involvement of the digestive system in COVID-19. A review date: 2020-10-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The SARS-CoV-2 pandemic is leading to high mortality and a global health crisis. The primary involvement is respiratory; however, the virus can also affect other organs, such as the gastrointestinal tract and liver. The most common symptoms are anorexia and diarrhea. In about half of the cases, viral RNA could be detected in the stool, which is another line of transmission and diagnosis. COVID19 has a worse prognosis in patients with comorbidities, although there is not enough evidence in case of previous digestive diseases. Digestive endoscopies may give rise to aerosols, which make them techniques with a high risk of infection. Experts and scientific organizations worldwide have developed guidelines for preventive measures. The available evidence on gastrointestinal and hepatic involvement, the impact on patients with previous digestive diseases and operating guidelines for Endoscopy Units during the pandemic are reviewed. url: https://www.sciencedirect.com/science/article/pii/S2444382420301565 doi: 10.1016/j.gastre.2020.06.004 id: cord-004404-s6udpwxq author: Seifi, Najmeh title: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies date: 2020-02-24 words: 4629.0 sentences: 281.0 pages: flesch: 41.0 cache: ./cache/cord-004404-s6udpwxq.txt txt: ./txt/cord-004404-s6udpwxq.txt summary: METHODS: This is a prospective, single-center, double-blind, parallel randomized controlled trial with the aim to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in critically ill patients. DISCUSSION: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency, and length of ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism. Previous studies suggest that modulating gut microbiota by novel therapeutics, such as prebiotics, probiotics, or synbiotics, can have an effect on gastrointestinal tolerance and complications of enteral nutrition, which eventually lead to the regulation of energy intake. Considering the extreme dysbiosis in critically ill patients and related energy and macronutrients homeostasis disturbance and muscle wasting, prompted us to evaluate the effect of synbiotic supplementation on the elimination of this condition. The primary objective is to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in patients under critical care. abstract: BACKGROUND: An extreme and persistent dysbiosis occurs among critically ill patients, regardless of the heterogeneity of disease. Dysbiosis in critically ill patients may make them prone to hospital-acquired infections, sepsis, multi-organ failure (MOF), energy homeostasis disturbance, muscle wasting, and cachexia. Modulation of gut microbiota through synbiotics can be considered as a potential treatment for muscle wasting and macronutrient homeostasis disturbances. METHODS: This is a prospective, single-center, double-blind, parallel randomized controlled trial with the aim to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in critically ill patients. A total of 40 hemodynamically stable, adult, critically ill patients who receive enteral nutrition via a nasogasteric tube (NGT) in the 24–48 h after admission to critical care will be included in this study. Eligible patients will be randomly assigned to receive Lactocare (ZistTakhmir) capsules 500 mg every 12 h or a placebo capsule, which contains only the sterile maize starch and is similar to synbiotic capsules for 14 days. The synbiotic and placebo capsules will be given through the nasogastric tube, separately from gavage, after feeding. DISCUSSION: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency, and length of ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism. TRIAL REGISTRATION: Iranian Registry of Clinical Trials, IRCT20190227042857N1. Registered on 17 March 2019. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041281/ doi: 10.1186/s13063-020-4136-3 id: cord-279056-mmcoqtb5 author: Seirafianpour, Farnoosh title: Cutaneous manifestations and considerations in COVID‐19 pandemic: A systematic review date: 2020-07-08 words: 4651.0 sentences: 262.0 pages: flesch: 46.0 cache: ./cache/cord-279056-mmcoqtb5.txt txt: ./txt/cord-279056-mmcoqtb5.txt summary: BACKGROUND: COVID‐19 had a great impact on medical approaches among dermatologist OBJECTIVE: This systematic review focuses on all skin problems related to COVID‐19, including primary and secondary COVID‐related cutaneous presentations and the experts recommendations about dermatological managements especially immunomodulators usage issues METHOD: Search was performed on PubMed, Scopus, Embase and ScienceDirect. Totally 5 article were about skin drug reactions of COVID-19 treatments; two of them were original studies as case reports that were summarized in Table 7 (in the supplement file). In overall, non-infected non-at risk patients with immune-medicated dermatologic disorders under usage of immunosuppressive immunomodulator drugs like biologic agents are not needed to be alter regimen or discontine the therapies during pandemic, even these drugs may control the deteriorating cytokine storms also prevented disease flare-ups which both were associated with poorer outcomes and more complications in COVID-19 course, although strict adherence to quarantine and personal-social preventive hygiene performances are highly recommended especially in these groups of patients. abstract: BACKGROUND: COVID‐19 had a great impact on medical approaches among dermatologist OBJECTIVE: This systematic review focuses on all skin problems related to COVID‐19, including primary and secondary COVID‐related cutaneous presentations and the experts recommendations about dermatological managements especially immunomodulators usage issues METHOD: Search was performed on PubMed, Scopus, Embase and ScienceDirect. Other additional resources were searched included Cochrane, WHO, Medscape and coronavirus dermatology resource of Nottingham university. The search completed on May/03/2020. 377 articles assigned to the inclusion and exclusion groups RESULT: Eighty‐nine articles entered the review. Primary mucocutaneous and appendageal presentations could be the initial or evolving signs of COVID‐19. It could be manifest most commonly as a maculopapular exanthamatous or morbiliform eruption, generalized urticaria or pseudo chilblains recognized as “COVID toes” (pernio‐like acral lesions or vasculopathic rashes). Conclusion: During pandemic, Non‐infected non‐at risk patients with immune‐medicated dermatologic disorders under treatment with immunosuppressive immunomodulators are not needed to alter their regimen or discontinue the therapies. At‐risk and infection‐suspected patients needed to dose reduction, interval increase or temporary drug discontinuation (at least 2 weeks). Patients with an active COVID‐19 infection should hold the biologic or non‐biologic immunosuppressives until the complete recovery occur (at least 4 weeks). This article is protected by copyright. All rights reserved. url: https://doi.org/10.1111/dth.13986 doi: 10.1111/dth.13986 id: cord-006344-de4dhv4b author: Seitsonen, E. title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date: 2006-03-21 words: 2771.0 sentences: 174.0 pages: flesch: 48.0 cache: ./cache/cord-006344-de4dhv4b.txt txt: ./txt/cord-006344-de4dhv4b.txt summary: title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection Reported here are two cases of hantavirus pulmonary syndrome caused by Puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. We describe two cases of PUU-associated HPS, in which administration of intravenous corticosteroids combined with continuous veno-venous hemodiafiltration (CVVHDF) was followed by rapid clinical improvement. On day 5 POS the lung infiltrates had increased considerably (Fig. 3a,b) , and the patient required continuous ventilation with a positive airway pressure mask. We describe two cases of PUU-infected patients who presented with both renal and respiratory failure requiring renal replacement therapy and mechanical ventilation. High levels of cytokineproducing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome High levels of viremia in patients with the Hantavirus pulmonary syndrome abstract: Reported here are two cases of hantavirus pulmonary syndrome caused by Puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. These cases emphasize the role of the inflammatory response in the pathogenesis of hantavirus pulmonary syndrome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101642/ doi: 10.1007/s10096-006-0117-z id: cord-302667-ei151qpd author: Sekar, Raghul title: Challenges Faced by an Otolaryngology Resident During Covid-19 Pandemic: An Indian Perspective date: 2020-09-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SARS-CoV-2 virus causing COVID-19 disease has brought tremendous strain on health care sectors around the world. Being a respiratory disease, COVID-19 has tremendous implications on the otolaryngology residency. Otolaryngology residents are dealing with great apprehension of getting infected while working with both COVID-19 and non-COVID patients. Further, drastic change in the routine has affected their residency training. Outpatient and Inpatient care, elective and emergency surgeries which are a crucial part of the residency training have taken a back seat. India being a densely populated country is still in the midst of the pandemic with cases increasing exponentially each day. This article enumerates the challenges faced by an otolaryngology resident during COVID-19 pandemic in a tertiary care hospital in India. url: https://www.ncbi.nlm.nih.gov/pubmed/32904852/ doi: 10.1007/s12070-020-02096-1 id: cord-285226-4ydvjmr3 author: Sekhar, Laligam N. title: The Future of Skull Base Surgery: A View Through Tinted Glasses date: 2020-06-27 words: 3704.0 sentences: 224.0 pages: flesch: 51.0 cache: ./cache/cord-285226-4ydvjmr3.txt txt: ./txt/cord-285226-4ydvjmr3.txt summary: This leads to an examination of recent developments in the field and outlines several promising areas of future improvement in skull base surgery, per se, as well as identifying new hospital support systems needed to accommodate these changes. These include, but are not limited to advances in imaging, Raman Spectroscopy and Microscopy, 3-dimensional printing and rapid prototyping, master-slave and semi-autonomous robots, artificial intelligence applications in all areas of medicine, tele-medicine, and green technologies in hospitals. 44 45 More recent technological introductions have proceeded to revolutionize the 46 treatment of challenging skull base pathology including the introduction of 47 endoscopic surgery, advances in neuroimaging, radiosurgery and high energy 48 focused radiotherapy, the perfection of vascular bypasses for replacement of 49 major arteries and venous sinuses involved by tumors 1,2,3 , and the use of skull 50 base approaches to treat complex vascular lesions. Humanoid robotic nursing assistants 558 will be developed and widely used in future due to health care worker shortages, 559 patients'' desire to have 24x7 nursing assistance, and the needs created by 560 infectious diseases wherein human-human contact must be minimized. abstract: ABSTRACT This article broadly outlines the potential advances in the field of skull base surgery, which may occur in the next 20 years based on many areas of current research in biology and technology. Many of these advances are also broadly applicable to other areas of neurosurgery. We ground our predictions for future developments in an exploration of what patients and surgeons most desire as outcomes for care. This leads to an examination of recent developments in the field and outlines several promising areas of future improvement in skull base surgery, per se, as well as identifying new hospital support systems needed to accommodate these changes. These include, but are not limited to advances in imaging, Raman Spectroscopy and Microscopy, 3-dimensional printing and rapid prototyping, master-slave and semi-autonomous robots, artificial intelligence applications in all areas of medicine, tele-medicine, and green technologies in hospitals. In addition, we review therapeutic approaches employing nanotechnology, genetic engineering and anti-tumoral antibodies, as well as stem cell technologies to repair damage caused by traumatic injuries, tumors, and iatrogenic injuries to the brain and cranial nerves. Additionally, we discuss the training requirements for future skull- base surgeons and stress the need for adaptability and change. However, the essential requirements for skull base surgeons remain unchanged, namely: knowledge, attention to details, technical skill, innovation, judgement, and compassion. Our conclusion is that active involvement in these rapidly evolving technologies will enable us to shape some of the future of our discipline to address the needs of both patients and our profession. url: https://www.ncbi.nlm.nih.gov/pubmed/32599213/ doi: 10.1016/j.wneu.2020.06.172 id: cord-016135-44pgjah8 author: Sen, Ayan title: Postoperative Management of Composite Tissue Graft Transplantation date: 2016-06-03 words: 2618.0 sentences: 160.0 pages: flesch: 42.0 cache: ./cache/cord-016135-44pgjah8.txt txt: ./txt/cord-016135-44pgjah8.txt summary: In this chapter, we will discuss general and specifi c postoperative management of patients following CTA. Face transplantation is a complex and long surgery that is associated with signifi cant perioperative challenges, and multiple postoperative complications. Postoperative severe graft edema is expected in most patients and head elevation at 30-45° will promote venous drainage and prevent VAP [ 1 ] . The most severe infections occur during times of over-immunosuppression, such as the induction phase or management of acute rejection. Maintenance immunosuppression involves a regime of tacrolimus, mycophenolate mofetil, and prednisone, and must be closely followed up for the duration of the patient''s or allograft''s life. The fi rst hand transplant recipient lost his graft due to rejection from noncompliance. Management of graft failure involves amputation followed by use of prosthesis or another transplant. Helping hands: caring for the upper extremity transplant patient abstract: Composite tissue allotransplantation (CTA) is the transplantation of body structures such as the limbs, larynx, abdominal wall, tendons, and face. This chapter discusses the general and specific postoperative management of patients following CTA. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120326/ doi: 10.1007/978-1-4939-6377-5_47 id: cord-346205-vqgcq3qt author: Sengillo, Jesse D. title: Importance of Patient Advocacy During the COVID-19 Pandemic date: 2020-09-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0002939420303676?v=s5 doi: 10.1016/j.ajo.2020.07.016 id: cord-023729-dipjubn7 author: Serlin, Michael H. title: Gastrointestinal Disorders in HIV date: 2009-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173545/ doi: 10.1016/b978-1-4160-2882-6.50027-7 id: cord-338741-gy3ovkrt author: Sethi, Atin title: Evaluation of Current Therapies for COVID-19 Treatment date: 2020-07-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The virus SARS-CoV-2, the etiological agent of COVID-19, is responsible for more than 400,000 deaths worldwide as of 10 June 2020. As a result of its recent appearance (December 2019), an efficacious treatment is not yet available. Although considered a lung infection since its emergence, COVID-19 is now causing multiple organ failure, requiring a continuous adjustment in the procedures. In this review, we summarize the current literature surrounding unproven therapies for COVID-19. Analyses of the clinical trials were grouped as chemotherapy, serotherapy, anticoagulant, and the use of human recombinant soluble ACE2 therapies. We conclude that, while no agent has hit the threshold for quality of evidence to demonstrate efficacy and safety, preliminary data show potential benefits. Moreover, there is a possibility for harm with these unproven therapies, and the decision to treat should be based on a comprehensive risk–benefit analysis. url: https://www.ncbi.nlm.nih.gov/pubmed/32707942/ doi: 10.3390/microorganisms8081097 id: cord-263285-89zqgqx1 author: Sethi, Sanjum S. title: Right Ventricular Clot in Transit in COVID-19: Implications for the Pulmonary Embolism Response Team date: 2020-05-29 words: 1855.0 sentences: 117.0 pages: flesch: 45.0 cache: ./cache/cord-263285-89zqgqx1.txt txt: ./txt/cord-263285-89zqgqx1.txt summary: After presenting a case of right ventricular thrombus in a COVID-19 patient, we discuss the unique challenges in the workup and treatment of COVID-19 patients highlighting our COVID-19 modified pulmonary embolism response team (PERT) algorithm. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19related critical illness and multiorgan dysfunction in a subset of those infected. Given these findings, the pulmonary embolism response team (PERT) was consulted and the patient was given 100 mg (over 2 hours) of tissue-type plasminogen activator (tPA) and systemic anticoagulation with unfractionated heparin once the tPA infusion was complete. The usual risk stratification schema for acute pulmonary embolism rely on a combination of hemodynamic clinical parameters, such as hypoxemia, tachycardia, and hypotension along with serum biomarkers, such as troponin or brain natriuretic peptide followed by confirmatory imaging tests. abstract: Abstract Severe acute respiratory syndrome coronavirus 2 is associated with a prothrombotic state in infected patients. After presenting a case of right ventricular thrombus in a COVID-19 patient, we discuss the unique challenges in the workup and treatment of COVID-19 patients highlighting our COVID-19 modified pulmonary embolism response team (PERT) algorithm. url: https://www.sciencedirect.com/science/article/pii/S2666084920305933?v=s5 doi: 10.1016/j.jaccas.2020.05.034 id: cord-280848-z0sbztkw author: Setzen, Michael title: COVID-19 and rhinology: A look at the future date: 2020-04-15 words: 2882.0 sentences: 133.0 pages: flesch: 47.0 cache: ./cache/cord-280848-z0sbztkw.txt txt: ./txt/cord-280848-z0sbztkw.txt summary: These include protocols pertinent to safety, in-office Rhinologic procedures, the substitution of imaging for endoscopy, and understanding the appropriate role of telemedicine. There has been controversy and significant concern regarding endoscopic evaluation of patients in the office, especially nasal endoscopy and flexible laryngoscopy, since performing these procedures puts one in direct contact with the virus as it resides primarily in nose and nasopharynx. To decrease nasal endoscopy procedures and minimize risk, organizations such as the American Rhinologic Society (ARS) should consider guidelines examining when it is appropriate to go straight to CT in select cases of possible COVID-19 now and in the future. In-Office CT sinus will continue to play an important role as a point of service procedure in lieu of nasal endoscopy in patients with COVID-19 or suspected thereof. This makes nasal endoscopy and other in-office rhinologic procedures a concern for the Otolaryngologist with increased risk for infection. abstract: The novel Coronavirus (COVID-19) has created a deadly pandemic that is now significantly impacting the United States. Otolaryngologists are considered high risk for contracting disease, as the virus resides in the nasal cavity, nasopharynx, and oropharynx. While valuable work has been publicized regarding several topics in Rhinology, we discuss other aspects of our specialty in further detail. There are several issues regarding Rhinologic practice that need to be clarified both for the current epidemic as well as for future expected “waves.” In addition, as the pandemic dies down, guidelines are needed to optimize safe practices as we start seeing more patients again. These include protocols pertinent to safety, in-office Rhinologic procedures, the substitution of imaging for endoscopy, and understanding the appropriate role of telemedicine. We discuss these aspects of Rhinology as well as practical concerns relating to telemedicine and billing, as these issues take on increasing importance for Rhinologists both in the present and the future. url: https://www.sciencedirect.com/science/article/pii/S0196070920301733 doi: 10.1016/j.amjoto.2020.102491 id: cord-326747-zwp13awk author: Sever, Mustafa title: Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients date: 2009-12-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Chlorine is a known pulmonary irritant gas that may cause acute damage in the respiratory system. In this paper, the socio-demographic and clinical characteristics of 39 accidentally exposed patients to chlorine gas are reported and different emergency treatment modalities are also discussed. METHODS: Two emergency departments applications were retrospectively analyzed for evaluation of accidental chlorine gas exposure for year 2007. Patients were classified into 3 groups according to severity of clinical and laboratory findings based on the literature and duration of land of stay in the emergency department. The first group was slightly exposed (discharged within 6 hours), second group moderately exposed (treated and observed for 24 hours), and third group was severely exposed (hospitalized). Most of the patients were initially treated with a combination of humidified oxygen, corticosteroids, and bronchodilators. RESULTS: The average age was 17.03 ± 16.01 years (95% CI). Seven (17.9%) of them were female and 29 (74.4%) were children. Twenty-four patients (61.5%) were included in the first, nine (23.1%) were in second and six (15.4%) were in the third group. The presenting symptoms were cough, nausea, and vomiting and conjunctiva hyperemia for the first group, first groups symptoms plus dyspnea for the second group. Second groups symptoms plus palpitation, weakness and chest tightness were for the third group. Cough and dyspnea were seen in 64.1% and 30.8% of the patients respectively. No patients died. CONCLUSIONS: The authors recommend that non symptomatic or slightly exposed patients do not need any specific treatment or symptomatic treatment is sufficient. KEYWORDS: Accidental; Chlorine exposure; Chlorine gas; Chlorine intoxication; Emergency department url: https://www.ncbi.nlm.nih.gov/pubmed/22481989/ doi: 10.4021/jocmr2009.12.1283 id: cord-280030-neqycg6v author: Sewlall, Nivesh H. title: Clinical Features and Patient Management of Lujo Hemorrhagic Fever date: 2014-11-13 words: 6567.0 sentences: 339.0 pages: flesch: 49.0 cache: ./cache/cord-280030-neqycg6v.txt txt: ./txt/cord-280030-neqycg6v.txt summary: BACKGROUND: In 2008 a nosocomial outbreak of five cases of viral hemorrhagic fever due to a novel arenavirus, Lujo virus, occurred in Johannesburg, South Africa. Distinctive treatment components of the one surviving patient included rapid commencement of the antiviral drug ribavirin and administration of HMG-CoA reductase inhibitors (statins), N-acetylcysteine, and recombinant factor VIIa. CONCLUSIONS: Lujo virus causes a clinical syndrome remarkably similar to Lassa fever. We describe the clinical features of the five recognized cases of Lujo hemorrhagic fever (LHF) in the 2008 outbreak in South Africa and summarize their clinical management, as well as providing additional epidemiologic detail, with a focus on the risks for secondary transmission. In 2008, an outbreak of a novel hemorrhagic fever virus called Lujo occurred in Johannesburg, South Africa, with secondary transmission from the index patient to four healthcare workers. abstract: BACKGROUND: In 2008 a nosocomial outbreak of five cases of viral hemorrhagic fever due to a novel arenavirus, Lujo virus, occurred in Johannesburg, South Africa. Lujo virus is only the second pathogenic arenavirus, after Lassa virus, to be recognized in Africa and the first in over 40 years. Because of the remote, resource-poor, and often politically unstable regions where Lassa fever and other viral hemorrhagic fevers typically occur, there have been few opportunities to undertake in-depth study of their clinical manifestations, transmission dynamics, pathogenesis, or response to treatment options typically available in industrialized countries. METHODS AND FINDINGS: We describe the clinical features of five cases of Lujo hemorrhagic fever and summarize their clinical management, as well as providing additional epidemiologic detail regarding the 2008 outbreak. Illness typically began with the abrupt onset of fever, malaise, headache, and myalgias followed successively by sore throat, chest pain, gastrointestinal symptoms, rash, minor hemorrhage, subconjunctival injection, and neck and facial swelling over the first week of illness. No major hemorrhage was noted. Neurological signs were sometimes seen in the late stages. Shock and multi-organ system failure, often with evidence of disseminated intravascular coagulopathy, ensued in the second week, with death in four of the five cases. Distinctive treatment components of the one surviving patient included rapid commencement of the antiviral drug ribavirin and administration of HMG-CoA reductase inhibitors (statins), N-acetylcysteine, and recombinant factor VIIa. CONCLUSIONS: Lujo virus causes a clinical syndrome remarkably similar to Lassa fever. Considering the high case-fatality and significant logistical impediments to controlled treatment efficacy trials for viral hemorrhagic fever, it is both logical and ethical to explore the use of the various compounds used in the treatment of the surviving case reported here in future outbreaks. Clinical observations should be systematically recorded to facilitate objective evaluation of treatment efficacy. Due to the risk of secondary transmission, viral hemorrhagic fever precautions should be implemented for all cases of Lujo virus infection, with specialized precautions to protect against aerosols when performing enhanced-risk procedures such as endotracheal intubation. url: https://www.ncbi.nlm.nih.gov/pubmed/25393244/ doi: 10.1371/journal.pntd.0003233 id: cord-353671-xjpzhsup author: Sgouros, George title: Radiopharmaceutical therapy in cancer: clinical advances and challenges date: 2020-07-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach to treating many types of cancer. In RPT, radiation is systemically or locally delivered using pharmaceuticals that either bind preferentially to cancer cells or accumulate by physiological mechanisms. Almost all radionuclides used in RPT emit photons that can be imaged, enabling non-invasive visualization of the biodistribution of the therapeutic agent. Compared with almost all other systemic cancer treatment options, RPT has shown efficacy with minimal toxicity. With the recent FDA approval of several RPT agents, the remarkable potential of this treatment is now being recognized. This Review covers the fundamental properties, clinical development and associated challenges of RPT. url: https://www.ncbi.nlm.nih.gov/pubmed/32728208/ doi: 10.1038/s41573-020-0073-9 id: cord-273929-kpcmy9x8 author: Shah, Jatin P. title: The impact of COVID‐19 on Head and Neck surgery, education, and training date: 2020-04-25 words: 2541.0 sentences: 122.0 pages: flesch: 53.0 cache: ./cache/cord-273929-kpcmy9x8.txt txt: ./txt/cord-273929-kpcmy9x8.txt summary: With a fragile future, how do we conduct our day-to-day activities, and plan to retain our robust education and training programs, to educate and train the next generation of head and neck surgeons? 1 The drastic changes that have affected our work and life during the past 2 months have taught us that remote communications, education, teaching, learning and training are possible and have to be incorporated in our current systems. The IFHNOS has taken a lead on developing the first remote learning online fellowship program in head and neck surgery and oncology, which has been in existence for the past 6 years. In head and neck surgery, the stringent follow-up schedule was designed on the basis that nearly 80% of the patients who were to recur, would have recurred in the first 24 months, with a median time to recurrence of 9 months. The impact of COVID-19 on Head and Neck surgery, education, and training abstract: nan url: https://doi.org/10.1002/hed.26188 doi: 10.1002/hed.26188 id: cord-017617-13m7pmvq author: Shah, Nirav title: Traveler to Uganda date: 2017-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A 25-year-old, otherwise healthy woman traveled to Uganda. Two weeks after her return, she complained of dyspnea on exertion and cough. Several people who traveled with her displayed similar symptoms, and she suspected that she had an infection. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122223/ doi: 10.1007/978-3-319-64906-1_1 id: cord-258498-0mvxwo3w author: Shah, Saleha title: COVID-19 and paediatric dentistry- traversing the challenges. A narrative review date: 2020-08-21 words: 13560.0 sentences: 748.0 pages: flesch: 49.0 cache: ./cache/cord-258498-0mvxwo3w.txt txt: ./txt/cord-258498-0mvxwo3w.txt summary: This review article informs about measures which reduce facility risk, manage symptomatic patients and protect personal health care and management with reference to paediatric dentistry. 5, 6, 7 The risk of SARS-CoV-2 transmission via aerosols generated during dental procedures cannot be eliminated when practicing in the absence of Airborne Precautions (airborne infection isolation rooms or single-patient rooms, respiratory protection program, N95 respirators). 47 Primary prevention encompasses prenatal health care, avoidance of night time bottle feed with sugary drinks or milk, restricting sugar intake and frequency for children younger than 24 months, avoiding frequent/nocturnal breast or bottle feeding after 1 year, exposure to dietary fluoridate (water, milk, salt), use of an age appropriate amount of fluoride toothpaste containing at least 1000ppm fluoride for brushing at least twice a day, dental visit in the first year of life and regular applications of 5% fluoride. abstract: The coronavirus disease (COVID-19) pandemic has become a major global public health emergency with a focus on preventing the spread of this virus for controlling this crisis. A dental setting is at a high risk of cross infection amid patients and dental practitioner's owing to the spread of infection via droplets suspended in the air by infected symptomatic or asymptomatic subjects. This review article informs about measures which reduce facility risk, manage symptomatic patients and protect personal health care and management with reference to paediatric dentistry. url: https://www.sciencedirect.com/science/article/pii/S2049080120302557?v=s5 doi: 10.1016/j.amsu.2020.08.007 id: cord-282867-kbyxdegu author: Shah, Sayed Zulfiqar Ali title: Scaling the Need, Benefits, and Risks Associated with COVID-19 Acute and Postacute Care Rehabilitation: A Review date: 2020-08-26 words: 4542.0 sentences: 247.0 pages: flesch: 39.0 cache: ./cache/cord-282867-kbyxdegu.txt txt: ./txt/cord-282867-kbyxdegu.txt summary: The main aim of this study is to review and summarize the evidence regarding the supportive role of physical rehabilitation techniques in managing COVID-19-associated pneumonia. In this review, we also emphasize the use of rehabilitation techniques in the management of pneumonia in COVID-19-infected patients. The purpose of this study was to review the evidence regarding the supportive role of treatment options available in physical rehabilitation to manage COVID-19 pneumonia effectively. Evidence strongly supports that many rehabilitation techniques including chest physiotherapy and physical therapy modalities can be of great support to manage COVID-19-associated pneumonia [9, 10] . Common problems identified in COVID-19 patients that could be managed by rehabilitation specialists in the postacute phase include musculoskeletal pain, joint pain, reduced range of motion, muscular weakness, neuropathy and myopathy, pulmonary dysfunction, dysphagia, dyspnea, confusion, and impaired activities of daily living. abstract: Coronavirus is an RNA virus, which attacks the respiratory system causing complications including severe respiratory distress and pneumonia and many other symptoms. Recently, a novel coronavirus (COVID-19) outbreak emerged in Wuhan, which caused a significant number of infections in China and resulted in a global pandemic. The main aim of this study is to review and summarize the evidence regarding the supportive role of physical rehabilitation techniques in managing COVID-19-associated pneumonia. In this review, we also emphasize the use of rehabilitation techniques in the management of pneumonia in COVID-19-infected patients. Based on the evidence presented, we conclude that certain physical rehabilitation techniques and modalities could be of great support in the management of COVID-19-associated pneumonia. The safety of staff and patients when applying rehabilitation intervention requires attention. The combination of physical rehabilitation and medical treatment would result in improved treatment outcomes, faster recovery, and shorter hospital stay. Many rehabilitation techniques are safe and feasible and can be easily incorporated into the management protocol of COVID-19 victims. Decisions of early rehabilitation induction should be based on the patient's medical condition and tolerability. url: https://doi.org/10.1155/2020/3642143 doi: 10.1155/2020/3642143 id: cord-298325-2gm4fnqi author: Shah, Sonia title: Novel use of home pulse oximetry monitoring in COVID‐19 patients discharged from the emergency department identifies need for hospitalization date: 2020-06-17 words: 4001.0 sentences: 245.0 pages: flesch: 52.0 cache: ./cache/cord-298325-2gm4fnqi.txt txt: ./txt/cord-298325-2gm4fnqi.txt summary: title: Novel use of home pulse oximetry monitoring in COVID‐19 patients discharged from the emergency department identifies need for hospitalization OBJECTIVES: Our objective was to evaluate patient‐reported oxygen saturation (SpO(2)) using pulse oximetry as a home monitoring tool for patients with initially non‐severe COVID‐19 to identify need for hospitalization. CONCLUSIONS: This study found that home pulse oximetry monitoring identifies need for hospitalization in initially non‐severe COVID‐19 patients when a cut off of SpO(2) 92% is used. Our objective was to evaluate patient-reported oxygen saturation using pulse oximetry as a home monitoring tool for patients with initially non-severe COVID-19 to identify need for hospitalization. Our results found that pulse oximetry as a home monitoring tool identifies need for hospitalization in initially non-severe COVID-19 patients when a cut off of SpO 2 92% is used. This study found that home pulse oximetry monitoring identifies need for hospitalization in initially non-severe COVID-19 patients when resting home oxygen saturation drops below 92%. abstract: OBJECTIVES: Our objective was to evaluate patient‐reported oxygen saturation (SpO(2)) using pulse oximetry as a home monitoring tool for patients with initially non‐severe COVID‐19 to identify need for hospitalization. METHODS: Patients were enrolled at the emergency department (ED) and outpatient testing centers. Each patient was given a home pulse oximeter and instructed to record their SpO(2) every eight hours. Patients were instructed to return to the ED for sustained home SpO(2) <92% or if they felt they needed emergent medical attention. Relative risk was used to assess the relation between hospitalization and home SpO(2) <92% in COVID‐19 positive patients. RESULTS: We enrolled 209 patients with suspected COVID‐19, of which 77 patients tested positive for COVID‐19 and were included. Subsequent hospitalization occurred in 22/77 (29%) patients. Resting home SpO(2) <92% was associated with an increased likelihood of hospitalization compared to SpO(2) ≥92% [RR 7.0 (95% CI 3.4 – 14.5), p‐value <0.0001]. Home SpO2 <92% was also associated with increased risk of ICU admission, ARDS and septic shock. In our cohort, 50% of patients who ended up hospitalized only returned to the ED for incidental finding of low home SpO(2) without worsening of symptoms. One‐third (33%) of non‐hospitalized patients stated they would have returned to the ED if they did not have a pulse oximeter to reassure them at home. CONCLUSIONS: This study found that home pulse oximetry monitoring identifies need for hospitalization in initially non‐severe COVID‐19 patients when a cut off of SpO(2) 92% is used. Half of patients who ended up hospitalized had SpO(2) <92% without worsening symptoms. Home SpO(2) monitoring also reduces unnecessary ED revisits. url: https://www.ncbi.nlm.nih.gov/pubmed/32779828/ doi: 10.1111/acem.14053 id: cord-344004-z7pn7u6u author: Shaha, Ashok R. title: Thyroid surgery during COVID‐19 pandemic: Principles and philosophies date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1002/hed.26198 doi: 10.1002/hed.26198 id: cord-321237-ynhdii60 author: Shahroor, S. H. title: Adaptive split ventilator system enables parallel ventilation, individual monitoring and ventilation pressures control for each lung simulators date: 2020-04-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Objective: In mass crisis setting such as the COVID-19 pandemic, the number of patients requiring invasive ventilation may exceed the number of available ventilators. This challenge led to the concept of splitting ventilator between several patients, which aroused interest as well as a strong opposition from multiple professional societies (The joint statement)1.Establishment of a safe ventilator splitting setup which enables monitoring and control of each ventilated patient would be a desirable ability. Achieving independency between the Co-vent patients would enable effective coping with different individual clinical scenarios and broaden the pairing possibilities of patients connected to a single ventilator. We conducted an experiment to determine if our designed setup achieves these goals. Methods: We utilized a double two limbed modified ventilator circuits which were connected to dual lung simulators. Adding readily available pressure sensors (transducers), PEEP valves, flow control valves, one-way (check) valves and HME filters made the circuit safe enough and suitable for our goals. We first examined a single lung simulator establishing the baseline set parameters, while monitoring ventilator measures as Tidal Volume. The initial ventilator setting we chose was a controlled mandatory ventilation mode with a PIP (peak inspiratory pressure) of 25cmH2O, PEEP (Positive End Expiratory Pressure) of 5 cmH2O. In pressure control set at 20 cmH2O, the recorded mean TV( tidal volume) was 1000 mL (approximately 500 mL/lung simulator) with an average MV(minute ventilation) of 13 L/min (or 6.5 L/min/lung simulator). After examining the system with the dual modified circuits attached, and obtaining all the ventilation parameters, we simulated several clinical scenarios. We simulated clinical events such as: partial or full obstruction, disconnection, air leak and compliance differentials, which occur frequently on a ventilation course. Thus, it is a paramount system demand to keep undisturbed ventilation to the Co-vent patient A, while being challenged by patient B. Results: The adaptive split ventilator setup yields increased safety, monitoring, and controls ventilation parameters successfully for each connected simulated patient (using lung simulators).It also enables coping with several common clinical scenarios on a ventilation course, by allowing the care provider to control PIP and PEEP of each Co-Vent patient. Conclusion: In a mass crisis setting, when there is a shortage of ventilators supply, and as a last resort, this setup can be a viable option to act upon. This experiment demonstrates the ability of the split ventilator to ventilate dual lung simulators with increased safety, monitoring and ventilation pressures control of each simulated patient. This split ventilator kept supporting a simulated patient with undisturbed parameters while the CO-vent patient was simulated to be disconnected, having an air leak, or exhibiting lung compliance deterioration. To the best of our knowledge, this is the first time a split ventilator setup demonstrates these capabilities. Our pilot experiment suggests a significant potential of expanding the ventilator support resources, and is especially relevant during COVID-19 outbreak. Since this setup has not been used in a clinical setting yet, further research should be conducted to explore the safety limits and the capabilities of this model. url: https://doi.org/10.1101/2020.04.13.20064170 doi: 10.1101/2020.04.13.20064170 id: cord-356056-82bvcuvd author: Shaikh, Aasef G. title: Cerebellar Scholars’ Challenging Time in COVID-19 Pandemia date: 2020-04-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Novel coronavirus, SARS-CoV2, has caused pandemic of highly contagious disease called coronavirus disease 2019 (COVID-19), with epicenters in China, Italy, Spain, and the USA. Primarily affecting the human respiratory system, SARS-CoV2 has some impact on the human brain, but apparently minimal on the cerebellum, at least so far. Neurological involvement in the acute phase appears to manifest with confusion, dizziness, impaired consciousness, propensity to develop acute strokes, anosmia, hypogeusia, ataxia, epilepsy, and neuralgia. Cerebellar scholars are facing a time of uncertainty. Telemedicine has suddenly emerged as an alternative to follow patients. There is an urgent need to develop novel platforms to assess and follow ataxic patients remotely, especially because cerebellar patients often require ambulatory care to maintain their autonomy. url: https://www.ncbi.nlm.nih.gov/pubmed/32301047/ doi: 10.1007/s12311-020-01131-9 id: cord-348422-werg9ofa author: Shamsah, Mohammed A title: Right atrial thrombus in a patient with COVID-19 pneumonia: a case report date: 2020-09-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Significant coagulopathy and hyperinflammation are found in patients with coronavirus disease 2019 (COVID-19). Expert consensus has recommended prophylactic anticoagulation in COVID-19 patients due to the risk of thrombo-embolism. However, the use of therapeutic anticoagulation in these patients is still a matter of debate. CASE SUMMARY: We describe a patient with COVID-19 pneumonia and a clinical hyperinflammatory state. He developed early respiratory depression and required ventilation, and he subsequently developed haemodynamic instability. Point-of-care echocardiography demonstrated a right atrial thrombus and right ventricular dysfunction suggestive of acute massive pulmonary embolism. He was managed with veno-arterial extracorporeal membrane oxygenation and local thrombolysis. DISCUSSION: Critical cases of COVID-19 pneumonia are associated with hypercoagulation, and these patients should be monitored closely for complications. Therapeutic anticoagulation may play a role in the management and prevention of thrombo-embolism. url: https://doi.org/10.1093/ehjcr/ytaa296 doi: 10.1093/ehjcr/ytaa296 id: cord-316647-jj8anf5g author: Shang, You title: Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China date: 2020-06-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept all over the world, posing a great pressure on critical care resources due to large number of patients needing critical care. Statements from front-line experts in the field of intensive care are urgently needed. METHODS: Sixteen front-line experts in China fighting against the COVID-19 epidemic in Wuhan were organized to develop an expert statement after 5 rounds of expert seminars and discussions to provide trustworthy recommendation on the management of critically ill COVID-19 patients. Each expert was assigned tasks within their field of expertise to provide draft statements and rationale. Parts of the expert statement are based on epidemiological and clinical evidence, without available scientific evidences. RESULTS: A comprehensive document with 46 statements are presented, including protection of medical personnel, etiological treatment, diagnosis and treatment of tissue and organ functional impairment, psychological interventions, immunity therapy, nutritional support, and transportation of critically ill COVID-19 patients. Among them, 5 recommendations were strong (Grade 1), 21 were weak (Grade 2), and 20 were experts’ opinions. A strong agreement from voting participants was obtained for all recommendations. CONCLUSION: There are still no targeted therapies for COVID-19 patients. Dynamic monitoring and supportive treatment for the restoration of tissue vascularization and organ function are particularly important. url: https://doi.org/10.1186/s13613-020-00689-1 doi: 10.1186/s13613-020-00689-1 id: cord-327545-y3vejwtr author: Shannon, Vickie R. title: Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity date: 2020-09-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The immune checkpoints associated with the CTLA-4 and PD-1 pathways are critical modulators of immune activation. These pathways dampen the immune response by providing brakes on activated T cells, thereby ensuring more uniform and controlled immune reactions and avoiding immune hyper-responsiveness and autoimmunity. Cancer cells often exploit these regulatory controls through a variety of immune subversion mechanisms, which facilitate immune escape and tumor survival. Immune checkpoint inhibitors (ICI) effectively block negative regulatory signals, thereby augmenting immune attack and tumor killing. This process is a double-edged sword in which release of regulatory controls is felt to be responsible for both the therapeutic efficacy of ICI therapy and the driver of immune-related adverse events (IrAEs). These adverse immune reactions are common, typically low-grade and may affect virtually every organ system. In the early clinical trials, lung IrAEs were rarely described. However, with ever-expanding clinical applications and more complex ICI-containing regimens, lung events, in particular, pneumonitis, have become increasingly recognized. ICI-related lung injury is clinically distinct from other types of lung toxicity and may lead to death in advanced stage disease. Thus, knowledge regarding the key characteristics and optimal treatment of lung-IrAEs is critical to good outcomes. This review provides an overview of lung-IrAEs, including risk factors and epidemiology, as well as clinical, radiologic, and histopathologic features of ICI-related lung injury. Management principles for ICI-related lung injury, including current consensus on steroid refractory pneumonitis and the use of other immune modulating agents in this setting are also highlighted. url: https://www.ncbi.nlm.nih.gov/pubmed/32880733/ doi: 10.1007/s00520-020-05708-2 id: cord-269280-1zbxjmxu author: Shao, Connie title: The COVID trolley dilemma date: 2020-05-14 words: 2900.0 sentences: 152.0 pages: flesch: 59.0 cache: ./cache/cord-269280-1zbxjmxu.txt txt: ./txt/cord-269280-1zbxjmxu.txt summary: As the first wave of this pandemic subsides, hospital systems are faced with prioritizing which surgical services can resume while simultaneously minimizing the disruption of ongoing care for the remaining COVID-19 patients. Patients requiring oncologic surgery now face a "double jeopardy" of increased exposure to COVID-19 due to frequent interactions with medical facilities, but also worse outcomes associated with delaying surgery. As the immediate wave of morbidity and mortality associated directly with the COVID-19 pandemic subsides, the effects of delaying both diagnosis and surgery will be revealed. Guidelines, such as those created by ACS, for careful and precarious resumption of local "elective" surgeries are moot when conservation efforts are overrun by an uncontrolled Ro. At a time that we do not have herd immunity and a vaccine does not yet exist, government-mandated orders are necessary to protect our patients, ourselves, and those who will become our patients. abstract: nan url: https://doi.org/10.1016/j.amjsurg.2020.05.012 doi: 10.1016/j.amjsurg.2020.05.012 id: cord-314826-usfvulc2 author: Sharifipour, Ehsan title: Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU date: 2020-09-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: COVID-19 is known as a new viral infection. Viral-bacterial co-infections are one of the biggest medical concerns, resulting in increased mortality rates. To date, few studies have investigated bacterial superinfections in COVID-19 patients. Hence, we designed the current study on COVID-19 patients admitted to ICUs. METHODS: Nineteen patients admitted to our ICUs were enrolled in this study. To detect COVID-19, reverse transcription real-time polymerase chain reaction was performed. Endotracheal aspirate samples were also collected and cultured on different media to support the growth of the bacteria. After incubation, formed colonies on the media were identified using Gram staining and other biochemical tests. Antimicrobial susceptibility testing was carried out based on the CLSI recommendations. RESULTS: Of nineteen COVID-19 patients, 11 (58%) patients were male and 8 (42%) were female, with a mean age of ~ 67 years old. The average ICU length of stay was ~ 15 days and at the end of the study, 18 cases (95%) expired and only was 1 case (5%) discharged. In total, all patients were found positive for bacterial infections, including seventeen Acinetobacter baumannii (90%) and two Staphylococcus aureus (10%) strains. There was no difference in the bacteria species detected in any of the sampling points. Seventeen of 17 strains of Acinetobacter baumannii were resistant to the evaluated antibiotics. No metallo-beta-lactamases -producing Acinetobacter baumannii strain was found. One of the Staphylococcus aureus isolates was detected as methicillin-resistant Staphylococcus aureus and isolated from the patient who died, while another Staphylococcus aureus strain was susceptible to tested drugs and identified as methicillin-sensitive Staphylococcus aureus. CONCLUSIONS: Our findings emphasize the concern of superinfection in COVID-19 patients due to Acinetobacter baumannii and Staphylococcus aureus. Consequently, it is important to pay attention to bacterial co-infections in critical patients positive for COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32873235/ doi: 10.1186/s12879-020-05374-z id: cord-333588-3krh1xzx author: Sharma, Amita title: Pediatric Dentistry during Coronavirus Disease-2019 Pandemic: A Paradigm Shift in Treatment Options date: 2020 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease-2019 (COVID-19) pandemic has affected the world in an aggressive manner and the healthcare fraternity has been at the forefront in this fight. Dental professionals are at a larger risk to get afflicted owing to the proximity to the oral cavity. Along with other verticals of dentistry, pediatric dentistry too has to adapt quickly keeping in mind the newer protocols so as to limit the increase of the global epidemic and the commencement of cross-infections. The purpose of this article is to present different treatment options for a pediatric dentist so as to achieve positive dental outcomes. HOW TO CITE THIS ARTICLE: Sharma A, Jain MB. Pediatric Dentistry during Coronavirus Disease-2019 Pandemic: A Paradigm Shift in Treatment Options. Int J Clin Pediatr Dent 2020;13(4):412–415. url: https://doi.org/10.5005/jp-journals-10005-1809 doi: 10.5005/jp-journals-10005-1809 id: cord-324810-92fosk3c author: Sharma, Sat title: Role of Antimicrobial Agents in the Management of Exacerbations of COPD date: 2012-08-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a common occurrence and characterize the natural history of the disease. Over the past decade, new knowledge has substantially enhanced our understanding of the pathogenesis, outcome and natural history of AECOPD. The exacerbations not only greatly reduce the quality of life of these patients, but also result in hospitalization, respiratory failure, and death. The exacerbations are the major cost drivers in consumption of healthcare resources by COPD patients. Although bacterial infections are the most common etiologic agents, the role of viruses in COPD exacerbations is being increasingly recognized. The efficacy of antimicrobial therapy in acute exacerbations has established a causative role for bacterial infections. Recent molecular typing of sputum isolates further supports the role of bacteria in AECOPD. Isolation of a new strain of Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae was associated with a considerable risk of an exacerbation. Lower airway bacterial colonization in stable patients with COPD instigates airway inflammation, which leads to a protracted self-perpetuating vicious circle of progressive lung damage and disease progression. A significant proportion of patients treated for COPD exacerbation demonstrate incomplete recovery, and frequent exacerbations contribute to decline in lung function. The predictors of poor outcome include advanced age, significant impairment of lung function, poor performance status, comorbid conditions and history of previous frequent exacerbations requiring antibacterials or systemic corticosteroids. These high-risk patients, who are likely to harbor organisms resistant to commonly used antimicrobials, should be identified and treated with antimicrobials with a low potential for failure. An aggressive management approach in complicated exacerbations may reduce costs by reducing healthcare utilization and hospitalization. url: https://www.ncbi.nlm.nih.gov/pubmed/15987232/ doi: 10.2165/00151829-200504030-00001 id: cord-256459-6h358si5 author: Sharpstone, D title: Gastrointestinal manifestations of HIV infection date: 1996-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The harrowing picture of emaciated terminally ill AIDS patients is a reminder of our lack of understanding of immunological mechanisms that normally control opportunistic infections. Many gastrointestinal pathogens in patients with AIDS are resistant to treatment and lead inexorably to weight loss and death. Although knowledge of the pathogenesis and clinical significance of weight loss has improved considerably, this has not yet led to a sustained effort to improve nutritional status during early stages of disease. url: https://www.sciencedirect.com/science/article/pii/S0140673696010343 doi: 10.1016/s0140-6736(96)01034-3 id: cord-336450-2ndan331 author: Shaw, Katharina S. title: Response to “Patient preference for cellulitis treatment: at-home care is preferred to hospital-based treatment” date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S0190962220323604 doi: 10.1016/j.jaad.2020.07.120 id: cord-300608-eju7wnb9 author: Sheervalilou, Roghayeh title: COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease date: 2020-05-26 words: 7391.0 sentences: 384.0 pages: flesch: 47.0 cache: ./cache/cord-300608-eju7wnb9.txt txt: ./txt/cord-300608-eju7wnb9.txt summary: 2.1 | Respiratory system SARS-CoV-2 tends to infect the respiratory tract, thus, pneumonia is a primary clinical finding in patients with COVID-19 Li, Guan, et al., 2020; Zhu et al., 2020) . A number of investigations recently conducted on COVID-19 have reported that IL-6 levels was actually higher in the patients with severe disease (Cai, 2020; Chen, Liu, et al., 2020; Xiang et al., 2020) . Impaired liver function tests have been reported for a number of patients with SARS-CoV-2 infection, suggesting hepatic damage as an extrapulmonary complication of COVID-19 in almost one half of the patients (Chen, Zhou, et al., 2020; Wang, Hu, et al., 2020) . Since H7N9 and SARS-CoV-2 can result in similar complications, for example, ARDS and respiratory failure, MSC-based therapy might lead to a new path in treatment of COVID-19-associated pneumonia . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan abstract: Months after the outbreak of a new flu‐like disease in China, the entire world is now in a state of caution. The subsequent less‐anticipated propagation of the novel coronavirus disease, formally known as COVID‐19, not only made it to headlines by an overwhelmingly high transmission rate and fatality reports, but also raised an alarm for the medical community all around the globe. Since the causative agent, SARS‐CoV‐2, is a recently discovered species, there is no specific medicine for downright treatment of the infection. This has led to an unprecedented societal fear of the newly born disease, adding a psychological aspect to the physical manifestation of the virus. Herein, the COVID‐19 structure, epidemiology, pathogenesis, etiology, diagnosis, and therapy have been reviewed. url: https://doi.org/10.1002/jcp.29735 doi: 10.1002/jcp.29735 id: cord-306790-82nltfk3 author: Sheikh, Abu Baker title: Inferior Wall Myocardial Infarction in Severe COVID-19 Infection: A Case Report date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patient: Male, 56-year-old Final Diagnosis: COVID-19 Symptoms: Hypoxemia • pneumonia Medication:— Clinical Procedure: — Specialty: Cardiology OBJECTIVE: Unusual clinical course BACKGROUND: The novel coronavirus disease (COVID-19) has been declared a pandemic. With the ever-increasing number of COVID-19 patients, it is imperative to explore the factors related to the disease to aid patient management until a definitive vaccine is ready, as the disease is not limited to the respiratory system alone. COVID-19 has been associated with various cardiovascular complications including acute myocardial injury, myocarditis, arrhythmias, and venous thromboembolism. The infection is severe in patients with pre-existing cardiovascular disease, and a systemic inflammatory response due to a cytokine storm in severe COVID-19 cases can lead to acute myocardial infarction. CASE REPORT: We present the case of a 56-year-old man with cardiovascular risk factors including coronary artery disease, hypertension, ischemic cardiomyopathy, and hyperlipidemia, who had COVID-19-induced pneumonia complicated with acute respiratory distress syndrome. He subsequently developed myocardial infarction during his hospitalization at our facility. He had a significant contact history for COVID-19. He was managed with emergent cardiac revascularization after COVID-19 was confirmed by real-time reverse transcription-polymerase chain reaction testing from a nasopharyngeal swab as per hospital policy for admitted patients. Apart from dual antiplatelet therapy, tocilizumab therapy was initiated due to the high interleukin-6 levels. His hospitalization was complicated by hemodialysis and failed extubation and intubation, resulting in a tracheostomy. Upon improvement, he was discharged to a long-term facility with a plan for outpatient follow-up. CONCLUSIONS: In high-risk patients with COVID-19-induced pneumonia and cardiovascular risk factors, a severe systemic inflammatory response can lead to atherosclerotic plaque rupture, which can manifest as acute coronary syndrome. url: https://www.ncbi.nlm.nih.gov/pubmed/32981926/ doi: 10.12659/ajcr.926101 id: cord-011413-yv4x8viu author: Shekar, Kiran title: Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date: 2020-05-12 words: 7479.0 sentences: 535.0 pages: flesch: 41.0 cache: ./cache/cord-011413-yv4x8viu.txt txt: ./txt/cord-011413-yv4x8viu.txt summary: The Extracorporeal Life Support Organization (ELSO) Coronavirus Disease 2019 (COVID-19) Guidelines have been developed to assist existing extracorporeal membrane oxygenation (ECMO) centers to prepare and plan provision of ECMO during the ongoing pandemic. 11 The interim recommendations presented here balance the need to provide high-quality ECMO care to those who may benefit most while being cognizant of available resources and maintaining an environment of patient and staff safety (Figure 1) . In addition, the Extracorporeal Life Support Organization (ELSO) COVID-19 Working Group Members completed a survey on patient selection criteria for ECMO to build consensus. We recommend the following contraindications for ECMO in patients with cardiopulmonary failure due to COVID-19 (Table 1) in centers functioning under significant resource constraints, for example, Contingency Capacity ≥ Tier 1. International ECMO Network (ECMONet): Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients abstract: The Extracorporeal Life Support Organization (ELSO) Coronavirus Disease 2019 (COVID-19) Guidelines have been developed to assist existing extracorporeal membrane oxygenation (ECMO) centers to prepare and plan provision of ECMO during the ongoing pandemic. The recommendations have been put together by a team of interdisciplinary ECMO providers from around the world. Recommendations are based on available evidence, existing best practice guidelines, ethical principles, and expert opinion. This is a living document and will be regularly updated when new information becomes available. ELSO is not liable for the accuracy or completeness of the information in this document. These guidelines are not meant to replace sound clinical judgment or specialist consultation but rather to strengthen provision and clinical management of ECMO specifically, in the context of the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228451/ doi: 10.1097/mat.0000000000001193 id: cord-273317-2e3vmdx4 author: Shekhar, Rahul title: Neurological Complications Among Native Americans with COVID-19: Our Experience at a Tertiary Care Academic Hospital in the U.S. date: 2020-08-24 words: 1488.0 sentences: 109.0 pages: flesch: 56.0 cache: ./cache/cord-273317-2e3vmdx4.txt txt: ./txt/cord-273317-2e3vmdx4.txt summary: OBJECTIVE: To study the central nervous system (CNS) complications in patients with COVID-19 infection especially among Native American population in the current pandemic of severe acute respiratory syndrome virus (COVID-19). METHODS: Patients with confirmed COVID-19 infection at University of New Mexico hospital (UNMH) were screened for development of neurological complications during Feb 01 to April 29, 2020 via retrospective chart review. Out of seven patients, majority were Native Americans females, and developed neurological complications including subarachnoid hemorrhage (SAH), Intraparenchymal hemorrhage (IPH), Ischemic stroke (IS) and seizure. CONCLUSION: Patients with serious CNS complications secondary to COVID-19 infection were observed to be Native Americans. 4 We share a case series of seven patients, all except one of whom, were Native Americans (NA), and experienced CNS complications during the admission of COVID-19. Patients diagnosed with COVID-19 via reverse transcriptase-polymerase chain reaction (RT-PCR) from nasal swab were screened for development of neurological complications (ischemic stroke, intracerebral hemorrhage, sub-arachnoid hemorrhage, seizure, and encephalitis). abstract: OBJECTIVE: To study the central nervous system (CNS) complications in patients with COVID-19 infection especially among Native American population in the current pandemic of severe acute respiratory syndrome virus (COVID-19). METHODS: Patients with confirmed COVID-19 infection at University of New Mexico hospital (UNMH) were screened for development of neurological complications during Feb 01 to April 29, 2020 via retrospective chart review. RESULTS: Total of 90 hospitalized patients were screened. Out of seven patients, majority were Native Americans females, and developed neurological complications including subarachnoid hemorrhage (SAH), Intraparenchymal hemorrhage (IPH), Ischemic stroke (IS) and seizure. All 7 patients required Intensive care unit (ICU) level of care. Patients who developed CNS complications other than seizure were females in the younger age group (4 patients, 38-58 years) with poor outcome. Out of 7, three developed subarachnoid hemorrhage, two developed ischemic infarction, and four developed seizure. Two patients with hemorrhagic complication expired during the course of hospitalization. All three patients with seizure were discharged to home. CONCLUSION: Patients with serious CNS complications secondary to COVID-19 infection were observed to be Native Americans. Patients who developed hemorrhagic or ischemic events were observed to have poor outcomes as compared to patients who developed seizures. url: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105260 doi: 10.1016/j.jstrokecerebrovasdis.2020.105260 id: cord-299156-1dwsm3ie author: Shemer, Asaf title: Ocular involvement in coronavirus disease 2019 (COVID-19): a clinical and molecular analysis date: 2020-09-14 words: 3509.0 sentences: 214.0 pages: flesch: 56.0 cache: ./cache/cord-299156-1dwsm3ie.txt txt: ./txt/cord-299156-1dwsm3ie.txt summary: The aim of this study was to assess the clinical and molecular ocular involvement among patients with confirmed COVID-19 admitted to a tertiary care facility. CONCLUSIONS: Among patients admitted to a tertiary referral center with confirmed COVID-19, active conjunctival injection was noted in one out of five cases, and was associated with loss of smell and taste. Among patients with COVID-19, active conjunctival injection was associated with loss of smell and loss of taste as part of the clinical presentation (66.7% vs 7.7%, p = 0.018). In this study, we evaluated the ocular signs and symptoms, as well as the presence of SARS-CoV-2 in conjunctival swab samples among patients with COVID-19 in one tertiary referral center during March and April of 2020. To conclude, among patients admitted to a tertiary referral center with confirmed COVID-19, active conjunctival injection was present in 19% of cases and was associated with loss of smell and taste as part of the clinical presentation. abstract: PURPOSE: Coronavirus disease 2019 (COVID-19) caused a global pandemic with millions infected worldwide. Little is known on the ocular involvement associated with the disease. The aim of this study was to assess the clinical and molecular ocular involvement among patients with confirmed COVID-19 admitted to a tertiary care facility. METHODS: Consecutive patients admitted to the COVID-19 Ward of the Shamir Medical Center in Israel during March and April, 2020 were included. The control group included patients negative for COVID-19 admitted during a similar period to a different ward. Patients were examined by trained Ophthalmologists. SARS-CoV-2 conjunctival swab samples were obtained. RESULTS: Included were 48 patients, 16 with confirmed COVID-19 and 32 controls. Median patient age was 68.5 (interquartile range: 31.5, mean: 63 ± 21) years and 48% were male. Active conjunctival injection was present in three patients (19%) with COVID-19, compared to none in the controls (p = 0.034). Patients with COVID-19 were more likely to complain of foreign body sensation (31.3% vs 3.1%, p = 0.005) and redness of the eye (25% vs 0%, p = 0.003). Conjunctival injection was associated with loss of smell and taste (75% vs 7.7%, p = 0.018). Viral conjunctival swab tests all showed negative results for all three viral genes tested (E, N, and RdRp). CONCLUSIONS: Among patients admitted to a tertiary referral center with confirmed COVID-19, active conjunctival injection was noted in one out of five cases, and was associated with loss of smell and taste. Conjunctival swabs for viral RNA were negative in patients with and without ocular involvement. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10792-020-01592-1) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s10792-020-01592-1 doi: 10.1007/s10792-020-01592-1 id: cord-269981-xm0by310 author: Shen, Cheng title: Perioperative preparation in thoracic day surgery: Battle against COVID‐19 date: 2020-06-17 words: 1662.0 sentences: 90.0 pages: flesch: 48.0 cache: ./cache/cord-269981-xm0by310.txt txt: ./txt/cord-269981-xm0by310.txt summary: The day surgery center of West China Hospital is a hospital-based surgical setting that has nine operating rooms, a post-anesthesia care unit (PACU), 33 beds, and two nurse stations. Patients have to visit appropriate specialist clinics to evaluate whether they qualify for thoracic day surgery. In this scenario, patients must complete a thoracic specialist clinic evaluation and a COVID-19 epidemic survey. For the first time, patients must bring all their test results and anesthesia consultation to the Day Surgery Appointment Center for the surgeon to review and confirm whether all the tests have been completed prior to surgery. Generally, postoperative patients will transfer to the day surgery center ward after PACU for stage II recovery. To our knowledge, our data provide the first direct program and clinical pathway for thoracic day surgery to prevent the spread of COVID-19. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32558379/ doi: 10.1111/1759-7714.13500 id: cord-276327-wyevh4xv author: Sheng, Calvin C title: Canakinumab to reduce deterioration of cardiac and respiratory function in SARS‐CoV‐2 associated myocardial injury with heightened inflammation (canakinumab in Covid‐19 cardiac injury: The three C study) date: 2020-08-24 words: 3239.0 sentences: 192.0 pages: flesch: 37.0 cache: ./cache/cord-276327-wyevh4xv.txt txt: ./txt/cord-276327-wyevh4xv.txt summary: We designed a proof‐of‐concept randomized controlled trial to evaluate whether treatment with canakinumab prevents progressive respiratory failure and worsening cardiac dysfunction in patients with SARS‐CoV2 infection, myocardial injury, and high levels of inflammation. The three C Study is a prospective, IRB approved, blinded randomized-controlled Phase II study designed to evaluate whether treatment with canakinumab prevents progressive heart and respiratory failure in patients with Covid-19 associated myocardial injury and increased inflammation. This blinded randomized controlled trial is designed as a proof of concept study to demonstrate whether IL-1β antagonism can dampen the deleterious autoinflammatory response to SARS-CoV2 infection in patients with myocardial injury and heightened inflammation. In evaluating this hypothesis, the Three C study will help inform whether targeting inappropriate activation of the innate immune system should be investigated in larger clinical trials to improve survival in patients with Covid-19 and myocardial injury. abstract: BACKGROUND: In patients with Covid‐19, myocardial injury and increased inflammation are associated with morbidity and mortality. We designed a proof‐of‐concept randomized controlled trial to evaluate whether treatment with canakinumab prevents progressive respiratory failure and worsening cardiac dysfunction in patients with SARS‐CoV2 infection, myocardial injury, and high levels of inflammation. HYPOTHESIS: The primary hypothesis is that canakiumab will shorten time to recovery. METHODS: The three C study (canakinumab in Covid‐19 Cardiac Injury, NCT04365153) is a double‐blind, randomized controlled trial comparing canakinumab 300 mg IV, 600 mg IV, or placebo in a 1:1:1 ratio in hospitalized Covid‐19 patients with elevations in troponin and C‐reactive protein (CRP). The primary endpoint is defined as the time in days from randomization to either an improvement of two points on a seven category ordinal scale or discharge from the hospital, whichever occurs first up to 14 days postrandomization. The secondary endpoint is mortality at day 28. A total of 45 patients will be enrolled with an anticipated 5 month follow up period. RESULTS: Baseline characteristics for the first 20 randomized patients reveal a predominantly male (75%), elderly population (median 67 years) with a high prevalence of hypertension (80%) and hyperlipidemia (75%). CRPs have been markedly elevated (median 16.2 mg/dL) with modest elevations in high‐sensitivity troponin T (median 21 ng/L), in keeping with the concept of enrolling patients with early myocardial injury. CONCLUSIONS: The three C study will provide insights regarding whether IL‐1β inhibition may improve outcomes in patients with SARS‐CoV2 associated myocardial injury and increased inflammation. url: https://www.ncbi.nlm.nih.gov/pubmed/32830894/ doi: 10.1002/clc.23451 id: cord-294487-hcuzxhb3 author: Shenoi, Susan title: Telemedicine in pediatric rheumatology: this is the time for the community to embrace a new way of clinical practice date: 2020-10-31 words: 2102.0 sentences: 122.0 pages: flesch: 37.0 cache: ./cache/cord-294487-hcuzxhb3.txt txt: ./txt/cord-294487-hcuzxhb3.txt summary: The current COVID 19 global pandemic has forced a paradigm shift with many centers rapidly adopting virtual visits to conduct care resulting in rapid expansion of use of telemedicine amongst practices. BODY: This commentary discusses practical tips for physicians including guidance around administrative and governance issues, preparation for telemedicine, involving the multidisciplinary care team, and teaching considerations. CONCLUSION: This commentary provides a starting framework for telemedicine use in pediatric rheumatology and further work on validation and acceptability is needed. Virtual care models with remote clinics and video visits (e-visits or telemedicine) have become widespread practice overnight. This commentary describes practical creative approaches based on our experiences and discusses the potential for telemedicine to address unmet needs in the wider context of pediatric rheumatology. Young patients (< 3 years) are more challenging to keep on task with a virtual joint exam, but a care-giver only visit to discuss symptoms or medication side effects is often feasible. Decreasing patient cost and travel time through pediatric rheumatology telemedicine visits abstract: BACKGROUND: The use of telemedicine in pediatric rheumatology has been historically low. The current COVID 19 global pandemic has forced a paradigm shift with many centers rapidly adopting virtual visits to conduct care resulting in rapid expansion of use of telemedicine amongst practices. BODY: This commentary discusses practical tips for physicians including guidance around administrative and governance issues, preparation for telemedicine, involving the multidisciplinary care team, and teaching considerations. We also outline a standard proforma and smart phrases for the electronic health record. A proposed variation of the validated pediatric gait arms legs spine examination (pGALS) called the video pGALS (VpGALS) as a means of conducting virtual pediatric rheumatology physical examination is presented. CONCLUSION: This commentary provides a starting framework for telemedicine use in pediatric rheumatology and further work on validation and acceptability is needed. url: https://www.ncbi.nlm.nih.gov/pubmed/33129319/ doi: 10.1186/s12969-020-00476-z id: cord-355558-r6r1t47c author: Shenoy, Akhil title: Diabetes and covid-19: a global health challenge date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32345580/ doi: 10.1136/bmjdrc-2020-001450 id: cord-255435-mr239gai author: Sher, Yelizaveta title: A CASE REPORT OF COVID-19 ASSOCIATED HYPERACTIVE ICU DELIRIUM WITH PROPOSED PATHOPHYSIOLOGY AND TREATMENT date: 2020-05-19 words: 3528.0 sentences: 182.0 pages: flesch: 35.0 cache: ./cache/cord-255435-mr239gai.txt txt: ./txt/cord-255435-mr239gai.txt summary: Delirium, which is highly prevalent in general intensive care unit (ICU) populations, is expected to be frequent and prominent in COVID-19 patients hospitalized with acute respiratory distress syndrome (ARDS) in ICU. Delirium, which is highly prevalent in general intensive care unit (ICU) populations, is expected to be frequent and prominent in COVID-19 patients hospitalized with acute respiratory distress syndrome (ARDS) in ICU. In addition to case presentation, we discuss a proposed delirium pathophysiology in COVID-19 associated delirium and a systematized approach to evaluation and management of such patients. Intravenous valproic acid (VPA; titrated to 1250 mg per day) was also started for management of agitation and symptoms of hyperactive delirium and to facilitate tapering of multiple other sedative deliriogenic medications. At our center, the following medications have been used in management of agitation in patients with COVID-19 ICU-associated hyperactive delirium, including the described patient, with following considerations. abstract: There have been increasing reports of neuropsychiatric presentations and symptoms of COVID-19, more commonly seen in severely ill patients. Delirium, which is highly prevalent in general intensive care unit (ICU) populations, is expected to be frequent and prominent in COVID-19 patients hospitalized with acute respiratory distress syndrome (ARDS) in ICU. In this case report with associated review, we present a case of a critically ill patient with COVID-19 managed in ICU for ARDS. Psychiatry was consulted for management of her hyperactive delirium, likely complicated by environmental factors inherent in management of COVID-19 patients as well as the use of multiple sedatives. Patient was successfully managed by psychiatry with a combination of high-dose melatonin, suvorexant, guanfacine, intravenous haloperidol, and intravenous valproic acid. In addition to case presentation, we discuss a proposed delirium pathophysiology in COVID-19 associated delirium and a systematized approach to evaluation and management of such patients. url: https://api.elsevier.com/content/article/pii/S0033318220301456 doi: 10.1016/j.psym.2020.05.007 id: cord-007444-c9vu8ako author: Sherk, Peter A. title: The Chronic Obstructive Pulmonary Disease Exacerbation date: 2000-12-01 words: 9154.0 sentences: 479.0 pages: flesch: 40.0 cache: ./cache/cord-007444-c9vu8ako.txt txt: ./txt/cord-007444-c9vu8ako.txt summary: The three major bacterial pathogens isolated from patients with COPD during periods of both clinical stability and exacerbation are nontypeable Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella cafar~halis.~~ When FEV, is severely reduced, Enterobacteriaceae and Pseudomonas aeruginosa are also commonly detected.42 These organisms possess a wide array of virulence factors that allow them to evade clearance from the lower airways. Two randomized controlled trials evaluating the vaccine''s efficacy among patients with COPD were unable to show statistically significant protective benefit.36, 69 A recent meta-analysis concluded that the vaccine provides partial protection against bacteremic pneumococcal pneumonia but not against other important outcomes, including bronchitis or mortality caused by pneumococcal infection. The dose of methylprednisolone was high (125 mg every 6 hours for 3 days) and resulted in significantly more hyperglycemia and, possibly, increased secondary infection rates.''06 In summary, the evidence from randomized, controlled trials supports the conclusion that among patients with acute exacerbations, oral or intravenous corticosteroids significantly increase the FEV, for up to 72 hours and likely reduce the risk for treatment failure. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115724/ doi: 10.1016/s0272-5231(05)70179-9 id: cord-254494-wbfgrez1 author: Shi, Chunhong title: Barriers to Self-Management of Type 2 Diabetes During COVID-19 Medical Isolation: A Qualitative Study date: 2020-10-14 words: 5751.0 sentences: 338.0 pages: flesch: 45.0 cache: ./cache/cord-254494-wbfgrez1.txt txt: ./txt/cord-254494-wbfgrez1.txt summary: RESULTS: Barriers to diabetes self-management identified by patients with diabetes during isolation were categorized into five major themes: inadequate knowledge and behavioral beliefs, shortage of resources, suffering from health problems, negative emotions, and lack of support. Studies in developed countries such as the United States, Canada, the United Kingdom, and Singapore have found that common barriers to self-management include poor communication between patients and healthcare providers, limited accessibility to healthcare facilities, lack of family support, inadequate disease knowledge and limited disease treatment methods, lack of motivation for change, physical and cognitive disorders, limited access to diabetes education, and financial barriers. This study addressed a gap in this field by interviewing patients with diabetes subjected to medical isolation after recovering from COVID-19 to gain a deeper understanding of the barriers to diabetes self-management, and provide new perspectives and approaches for the design of interventions and formulation of policies. abstract: PURPOSE: Diabetes self-management behaviors are necessary to obtain optimum glycemic control, reduce the risk of complications, and improve health outcomes. The COVID-19 pandemic imposes an additional struggle for self-management by diabetes patients. Although previous studies have reported socio-demographic, behavioral, psychological, and cultural barriers to diabetes self-management, little is known about perceived barriers to diabetes self-management among patients during isolation following their recovery from COVID-19. The purpose of this study was to explore perceived barriers among type 2 diabetes patients during isolation following their recovery from COVID-19. PATIENTS AND METHODS: A qualitative, exploratory, and descriptive research design was utilized. Semi-structured telephonic interviews were conducted with 12 patients with diabetes who had been discharged from one COVID-19 designated hospital and underwent isolation in the designated facilities in Wuhan City, Hubei Province, China. Data were analyzed using Colaizzi’s seven steps. RESULTS: Barriers to diabetes self-management identified by patients with diabetes during isolation were categorized into five major themes: inadequate knowledge and behavioral beliefs, shortage of resources, suffering from health problems, negative emotions, and lack of support. CONCLUSION: Perceived barriers to diabetes self-management described by diabetes patients indicated a lack of environmental resources and support strategies to meet their needs. Efforts to remove barriers are important in assisting patients with diabetes to improve their quality of life and health outcomes. url: https://doi.org/10.2147/dmso.s268481 doi: 10.2147/dmso.s268481 id: cord-333429-bq7kfpby author: Shi, Ding title: Clinical characteristics and factors associated with long-term viral excretion in patients with SARS-CoV-2 infection: a single center 28-day study date: 2020-07-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Despite the ongoing spread of COVID-19, knowledge about factors affecting prolonged viral excretion is limited. METHODS: In this study, we retrospectively collected data from 99 hospitalized patients with COVID-19 between January 19 and February 17 in Zhejiang Province, China. We classified them into two groups based on whether the virus test results eventually became negative. Cox proportional hazards regression was used to evaluate factors associated with SARS-CoV-2 shedding. RESULTS: Among 99 patients, 61 patients had SARS-CoV-2 clearance (virus-negative group), but 38 patients had sustained positive results (virus-positive group). The median duration of SARS-CoV-2 excretion was 15 days (IQR 12-19) among the virus-negative patients. The shedding time was significantly increased if fecal SARS-CoV-2 RNA test results was positive. Male sex (HR, 0.58 [95% CI, 0.35-0.98]), immunoglobulin use (HR, 0.42 [95% CI, 0.24-0.76]), APACHE II score (HR, 0.89 [95% CI, 0.84-0.96]), and lymphocyte count (HR, 1.81 [95% CI, 1.05-3.1]) were independent factors associated with a prolonged duration of SARS-CoV-2 shedding. Antiviral therapy and corticosteroid treatment were not independent factors. CONCLUSIONS: SARS-CoV-2 RNA clearance time was associated with sex, disease severity and lymphocyte function. The current antiviral protocol and low-to-moderate dosage of corticosteroid had little effect on the duration of viral excretion. url: https://doi.org/10.1093/infdis/jiaa388 doi: 10.1093/infdis/jiaa388 id: cord-264673-67zopf7s author: Shi, Hongbo title: The inhibition of IL-2/IL-2R gives rise to CD8(+) T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia date: 2020-06-08 words: 3359.0 sentences: 209.0 pages: flesch: 55.0 cache: ./cache/cord-264673-67zopf7s.txt txt: ./txt/cord-264673-67zopf7s.txt summary: The count and percentage of lymphocytes were significantly decreased in critical patients compared to common and severe patients with COVID-19 pneumonia. The absolute lymphocyte count in patients with COVID-19 pneumonia was remarkably decreased compared with normal controls (Fig. 1a) . In addition, the percentage of lymphocyte in white blood cells (WBC) decreased in turn in common, severe, and critical patients, and the differences among them were statistically significant (Fig. 1d) . In addition, the expression of IL-2Rβ and IL-2Rγc in common, severe, and critical patients was significantly lower than that in normal Table 1 Clinical categorization of the patients with COVID-19 pneumonia by National Health Commission of China. The most significant finding of this study was the low level of IL-2 in plasma and low expression of IL-2R in PBMC of critical patients, which may result in the remarkable decrease of CD8 + T cell and lymphocytes in critical patients with COVID-19 pneumonia. abstract: Although most patients with COVID-19 pneumonia have a good prognosis, some patients develop to severe or critical illness, and the mortality of critical cases is up to 61.5%. However, specific molecular information about immune response in critical patients with COVID-19 is poorly understood. A total of 54 patients were enrolled and divided into three groups, among which 34 were common, 14 were severe, and 6 were critical. The constitution of peripheral blood mononuclear cells (PBMC) in patients was analyzed by CyTOF. The profile of cytokines was examined in plasma of patients using luminex. The IL-2 signaling pathway was investigated in the PBMC of patients by qRT-PCR. The count and percentage of lymphocytes were significantly decreased in critical patients compared to common and severe patients with COVID-19 pneumonia. The count of T cells, B cells, and NK cells was remarkably decreased in critical patients compared to normal controls. The percentage of CD8(+) T cells was significantly lower in critical patients than that in common and severe patients with COVID-19 pneumonia. The expression of IL-2R, JAK1, and STAT5 decreased in PBMC of common, severe, and critical patients, but IL-2 level was elevated in severe patients and decreased in critical patients with COVID-19 pneumonia. The decrease of CD8(+) T cells in critical patients with COVID-19 pneumonia may be related to the IL-2 signaling pathway. The inhibition of IL-2/IL-2R gives rise to CD8(+) T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia. url: https://www.ncbi.nlm.nih.gov/pubmed/32513989/ doi: 10.1038/s41419-020-2636-4 id: cord-295700-lzaxzuwe author: Shi, Shaobo title: Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 date: 2020-05-11 words: 3841.0 sentences: 192.0 pages: flesch: 42.0 cache: ./cache/cord-295700-lzaxzuwe.txt txt: ./txt/cord-295700-lzaxzuwe.txt summary: CONCLUSION: The risk of in-hospital death among patients with severe COVID-19 can be predicted by markers of myocardial injury, and was significantly associated with senior age, inflammatory response, and cardiovascular comorbidities. The major findings of the present study are as follows: (i) myocardial injury is not uncommon among patients with severe COVID-19, especially among those who die; (ii) elevated levels of myocardial markers predict risk for in-hospital death; and (iii) senior age, inflammatory response, and underlying cardiovascular-related comorbidities are associated with myocardial injury in patients with COVID-19. To further analyse related factors of myocardial injury by multivariable regression, senior age, comorbidities (e.g. hypertension, coronary heart disease, chronic renal failure, and chronic obstructive pulmonary disease), and inflammatory markers (e.g. PCT and C-reactive protein) were predictors of in-hospital myocardial injury in patients with severe COVID19 . cTnI and CK-MB levels predict risk for in-hospital death, and myocardial injury is associated with senior age, inflammatory response, and cardiovascular-related comorbidities. abstract: AIMS: To investigate the characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 (COVID-19). METHODS AND RESULTS: We enrolled 671 eligible hospitalized patients with severe COVID-19 from 1 January to 23 February 2020, with a median age of 63 years. Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. Risk factors of death and myocardial injury were analysed using multivariable regression models. A total of 62 patients (9.2%) died, who more often had myocardial injury (75.8% vs. 9.7%; P < 0.001) than survivors. The area under the receiver operating characteristic curve of initial cardiac troponin I (cTnI) for predicting in-hospital mortality was 0.92 [95% confidence interval (CI), 0.87–0.96; sensitivity, 0.86; specificity, 0.86; P < 0.001]. The single cut-off point and high level of cTnI predicted risk of in-hospital death, hazard ratio (HR) was 4.56 (95% CI, 1.28–16.28; P = 0.019) and 1.25 (95% CI, 1.07–1.46; P = 0.004), respectively. In multivariable logistic regression, senior age, comorbidities (e.g. hypertension, coronary heart disease, chronic renal failure, and chronic obstructive pulmonary disease), and high level of C-reactive protein were predictors of myocardial injury. CONCLUSION: The risk of in-hospital death among patients with severe COVID-19 can be predicted by markers of myocardial injury, and was significantly associated with senior age, inflammatory response, and cardiovascular comorbidities. url: https://www.ncbi.nlm.nih.gov/pubmed/32391877/ doi: 10.1093/eurheartj/ehaa408 id: cord-303661-etb19d6y author: Shin, Hyoung-Shik title: Empirical Treatment and Prevention of COVID-19 date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The rapid spread of severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) in the population and throughout the cells within our body has been developing. Another major cycle of coronavirus disease 2019 (COVID-19), which is expected in the coming fall, could be even more severe than the current one. Therefore, effective countermeasures should be developed based on the already obtained clinical and research information about SARS-CoV-2. The aim of this review was to summarize the data on the empirical treatment of COVID-19 acquired during this SARS-CoV-2 infection cycle; this would aid the establishment of an appropriate healthcare policy to meet the challenges in the future. The infectious disease caused by SARS-CoV-2 is characterized by common cold along with hypersensitivity reaction. Thus, in addition to treating common cold, it is essential to minimize the exposure of cells to the virus and to mitigate the uncontrolled immune response. A proper combination of antiviral agents, immune modulators such as prednisolone, and anticoagulants such as heparin and anti-C5a antagonists could be employed to minimize lung damage and prevent systemic involvements. Finally, strategies to achieve population immunity against SARS-CoV-2 should be developed through understanding of the interaction between the immune system and the virus. url: https://www.ncbi.nlm.nih.gov/pubmed/32476308/ doi: 10.3947/ic.2020.52.2.142 id: cord-287953-prn8cnvo author: Shin, Nina title: Effects of operational decisions on the diffusion of epidemic disease: A system dynamics modeling of the MERS-CoV outbreak in South Korea date: 2017-05-21 words: 6245.0 sentences: 302.0 pages: flesch: 41.0 cache: ./cache/cord-287953-prn8cnvo.txt txt: ./txt/cord-287953-prn8cnvo.txt summary: However, a number of hypotheses were generated to explain the spread, including: excessive patients'' freedom in seeking medical care at only large hospitals, inadequate quarantine, questionable government transparency, such as belated reports of infected hospital names, and the cultural social norm of visiting patients as standard etiquette ( Choe, 2015a ( Choe, , 2015b ; Korea Centers for Disease Control and Prevention, 2015 ) . Using a macro-level system dynamics modeling approach, our study intends to investigate the effect of operational decisions, such as patient-room design, occupancy control at emergency room and patient-visitor management, on the patient-care performance, such as number of infected patients (secondary infections) and financial burden on patients. The model illustrated in Fig. 3 depicts a high-level overview dynamics model of causal relationships between operational decisions (patient room designs, occupancy control at emergency room, patient-visitor management) and patient care performance (number of infected patients and average cost per patient). abstract: Abstract We evaluated the nosocomial outbreak of Middle East Respiratory Syndrome (MERS) Coronavirus (CoV) in the Republic of Korea, 2015, from a healthcare operations management perspective. Establishment of healthcare policy in South Korea provides patients’ freedom to select and visit multiple hospitals. Current policy enforces hospitals preference for multi-patient rooms to single-patient rooms, to lower financial burden. Existing healthcare systems tragically contributed to 186 MERS outbreak cases, starting from single “index patient” into three generations of secondary infections. By developing a macro-level health system dynamics model, we provide empirical knowledge to examining the case from both operational and financial perspectives. In our simulation, under base infectivity scenario, high emergency room occupancy circumstance contributed to an estimated average of 101 (917%) more infected patients, compared to when in low occupancy circumstance. Economic patient room design showed an estimated 702% increase in the number of infected patients, despite the overall 98% savings in total expected costs compared to optimal room design. This study provides first time, system dynamics model, performance measurements from an operational perspective. Importantly, the intent of this study was to provide evidence to motivate public, private, and government healthcare administrators’ recognition of current shortcomings, to optimize performance as a whole system, rather than mere individual aspects. url: https://www.sciencedirect.com/science/article/pii/S002251931730139X doi: 10.1016/j.jtbi.2017.03.020 id: cord-350679-69lv4wbz author: Shinde, Rajesh S. title: To Do or Not to Do?—A Review of Cancer Surgery Triage Guidelines in COVID-19 Pandemic date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 pandemic has emerged as a global health emergency involving more than 200 countries so far. The number of affected population is on rising, so is the mortality. This crisis has overwhelmed the healthcare infrastructures in many affected countries. Due to overall rising cancer incidence and specific concerns, a cohort of cancer patients forms a distinct subset of the population in whom a correct and timely treatment has a huge impact on the outcome. During this period, oncology care is definitely affected owing to many factors like lockdowns, reduced beds and deferral of elective cases to halt the spread of the pandemic. Surgery remains the best line of defence in many solid organ tumours especially in early stage and is potentially curative. China, the source of this pandemic, has taken more than 3 months to enter the post transitional phase of this pandemic. Deferring cancer surgeries for this long period may have a direct impact on the long-term outcomes of cancer patients. Many surgical oncology associations across the globe have come up with triage guidelines for surgical care of cancer patients; however, these are based on expert opinion rather than actual data. Herein, we intend to review these guidelines with respect to the risk of disease progression in cancer patients. In the absence of actual data on cancer surgery care during this pandemic, clinical decisions should be based on careful consideration of disease-related and patient-related factors. While some of the cancer surgeries can be safely delayed for some time, how long we can delay surgeries safely cannot be answered/ explained by any means. Thorough evaluation and discussion by an expert and experienced multidisciplinary team appears to be the most effective way forward. url: https://www.ncbi.nlm.nih.gov/pubmed/32395064/ doi: 10.1007/s13193-020-01086-7 id: cord-328307-378cfb23 author: Shirazi, Samira title: Sudden cardiac death in COVID-19 patients, a report of three cases date: 2020-07-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The mortality rate of coronavirus disease-19 (COVID-19) has been reported as 1–6% in most studies. The cause of most deaths has been acute pneumonia. Nevertheless, it has been noted that cardiovascular failure can also lead to death. Three COVID-19 patients were diagnosed based on reverse transcriptase-polymerase chain reaction of a nasopharyngeal swab test and radiological examinations in our hospital. The patients received medications at the discretion of the treating physician. In this case series, chest computed tomography scans and electrocardiograms, along with other diagnostic tests were used to evaluate these individuals. Sudden cardiac death in COVID-19 patients is not common, but it is a major concern. So, it is recommended to monitor cardiac condition in selected patients with COVID-19. url: https://doi.org/10.2217/fca-2020-0082 doi: 10.2217/fca-2020-0082 id: cord-006768-r2pa9qw0 author: Shobha, Vineeta title: Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India date: 2018-02-28 words: 3088.0 sentences: 206.0 pages: flesch: 51.0 cache: ./cache/cord-006768-r2pa9qw0.txt txt: ./txt/cord-006768-r2pa9qw0.txt summary: Patients who fulfilled any two of the four criteria proposed by the American College of Rheumatology, and those with clinical features of GPA with ANCA positivity and histopathological confirmation, were included in the study. Though we have sufficient information on the initial clinical presentations, the variable manifestations due to its multisystem involvement often delay the early diagnosis and treatment of this potentially treatable vasculitis. Considering the morbidity and mortality of this progressive vasculitis, knowledge of the various modes of presentation in various geographic regions is the key to early diagnosis and treatment. Clinical presentation as RPGN (28/38-66%) of those with renal GPA was the most common manifestation with 45% of Upper and lower respiratory involvement was seen in 63% of the patients which was much lower than the series from western and Asian data [12, 14, 15] . Wegener''s granulomatosis in India: clinical features, treatment and outcome of twenty five patients abstract: Granulomatosis with polyangiitis (GPA) previously known as Wegener’s granulomatosis is one of the forms of idiopathic systemic vasculitis. There is very scanty data available on GPA in Asian and Indian population. We studied data of 60 patients from southern India, diagnosed with GPA to describe the physical characteristics, the treatment, and outcome. Patients who fulfilled any two of the four criteria proposed by the American College of Rheumatology, and those with clinical features of GPA with ANCA positivity and histopathological confirmation, were included in the study. Disease activity and damage were assessed by Birmingham Vasculitis Activity Score v. 3 (BVAS v. 3) and Vasculitis Damage Index (VDI), respectively. Relapses were defined as recurrence of GPA of sufficient severity to require treatment or increase in the dose of treatment on a patient who was previously stable. Out of 60 patients, initial BVAS evaluation showed that 57 (95%) patients had severe disease and 3 (5%) patients had limited disease where median BVAS was 21.5 (range 17–44). Follow-up BVAS evaluation for severe disease showed that 13 (22.8%) patients continued with severe disease of which 9 patients did not survive, 24 (42.3%) had remission, 11 (19.2%) had persistent disease, and 9 (15.7%) were lost to follow-up. The mean VDI score was 2.5 ± 2. Renal involvement was established in 42 (70%) patients. Upper and lower respiratory involvement was seen in 38 (63%) patients. Nervous system involvement was noted in the 15 (25%) patients. Articular manifestations were seen in 16 (27%) patients. Diverse clinical manifestation delay early diagnosis and treatment of this potentially treatable vasculitis. Focused approach could expedite early diagnosis and can reduce the mortality. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102363/ doi: 10.1007/s10238-018-0492-7 id: cord-271483-33kuvpl7 author: Shojaei, Amirahmad title: COVID-19 and off label use of drugs: an ethical viewpoint date: 2020-05-08 words: 3184.0 sentences: 153.0 pages: flesch: 42.0 cache: ./cache/cord-271483-33kuvpl7.txt txt: ./txt/cord-271483-33kuvpl7.txt summary: Based on USFDA regulation, investigational use of off-label medications helps the development of their safety and efficacy which needs to be used in the context of a clinical study protocol [18] . Likewise, we would like to define pseudo-research as using off-label medications in clinical practice without obtaining the patient''s informed consent, and finally publishing the results of drug efficacy as a research article. To do this, the national and international regulatory bodies such as USFDA, and EU, as well as the national ones such as the National Committee of Ethics in Biomedical Research of Iran, should step out of their routine and codify a range of guidelines to address therapeutic and/or investigational use of off-label medications by highlighting the safety concerns of the off-label uses as well as respecting patients autonomy especially in critical situations such as the COVID-19 outbreak. However, the physicians should be careful that the information about the efficacy and safety of off-label medication in clinical practice should not be published as a research article. abstract: BACKGROUND: The COVID-19 outbreak is rapidly spread over the world and kills infected patients. There is no proven medication for its treatment, so, all of the medications used for treatment are considered to be off-label. Off-label uses are not under regulation in the outbreak because there is no specific regulation for this condition. OBJECTIVES: In this short communication we aim at describing two ways of off-label use as clinical practice or investigational use. Further, we will describe the third way of off-label use, we named it pseudo-research and then we will state the most possible ethical challenges of off-label use for better perceptions and responsibility. RESULTS: The WHO considers off-label uses as country-specific. All international regulatory bodies consider off-label prescription as the physician’s responsibility and legal by necessitating some requirements. There is no international guideline for regulating investigational off-label uses as clinical practice. CONCLUSION: There are different types of approaches, none of them is comprehensive and conclusive. Furthermore, respecting the four ethical principles necessitates codification and strict regulation of off-label uses either as clinical practice or investigational. Besides, compilation of a special guideline based on ethical principles especially non-maleficence and autonomy for investigational off-label uses in disasters is highly recommended. url: https://www.ncbi.nlm.nih.gov/pubmed/32385829/ doi: 10.1007/s40199-020-00351-y id: cord-017516-qbksb83c author: Si, Yain-Whar title: Hidden Cluster Detection for Infectious Disease Control and Quarantine Management date: 2009-09-30 words: 3358.0 sentences: 158.0 pages: flesch: 46.0 cache: ./cache/cord-017516-qbksb83c.txt txt: ./txt/cord-017516-qbksb83c.txt summary: Our prototype Infectious Disease Detection and Quarantine Management System (IDDQMS), which can identify and trace clusters of infection by mining patients'' history, is introduced in this paper. The SARS (Severe Acute Respiratory Syndrome) outbreak in 2003 and recent world-wide avian flu infections have contributed to the urgent need to search for efficient methods for prevention and control of highly infectious diseases. Given this background, this research aims to develop a decision support system which can be used to locate the source of an outbreak by mining clusters and communities from the patients'' past activities (testimonies) using techniques from infectious disease control, information visualization, and database management systems. IDDQMS (see Figure 1 ) consists of four modules; information extraction, data analysis, hidden cluster detection, and quarantine management. In this paper, we have described our novel prototype system on Infectious Disease Detection and Quarantine Management, which can be used to identify and trace clusters of infection by mining patients'' history. abstract: Infectious diseases that are caused by pathogenic microorganisms can spread fast and far, from one person to another, directly or indirectly. Prompt quarantining of the infected from the rest, coupled with contact tracing, has been an effective measure to encounter outbreaks. However, urban life and international travel make containment difficult. Furthermore, the length of incubation periods of some contagious diseases like SARS enable infected passengers to elude health screenings before first symptoms appear and thus to carry the disease further. Detecting and visualizing contact–tracing networks, and immediately identifying the routes of infection, are thus important. We apply information visualization and hidden cluster detection for finding cliques of potentially infected people during incubation. Preemptive control and early quarantine are hence possible by our method. Our prototype Infectious Disease Detection and Quarantine Management System (IDDQMS), which can identify and trace clusters of infection by mining patients’ history, is introduced in this paper. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122094/ doi: 10.1007/978-1-4419-0312-9_10 id: cord-284979-lyt98od1 author: Sia, Charmaine Si Min title: Critical Coronavirus Disease 2019 in a Hemodialysis Patient: A Proposed Clinical Management Strategy date: 2020-07-30 words: 2859.0 sentences: 161.0 pages: flesch: 43.0 cache: ./cache/cord-284979-lyt98od1.txt txt: ./txt/cord-284979-lyt98od1.txt summary: We report our experience in treating the first case of COVID-19 in a HD patient in Singapore who had a severe clinical course including acute respiratory distress syndrome and propose a clinical management strategy. We also highlight the importance of early recognition and intervention for disease control, dialysis support in an acute hospital isolation facility, deisolation protocol, and discharge planning due to prolonged viral shedding. A case series of an outbreak in a dialysis center in Wuhan, where HD patients were observed to have a milder disease course or total absence of symptoms with lower levels of serum inflammatory cytokines, suggested that this is due to the inability to mount an effective cellular immune response and hence an absence of cytokine release syndrome [3] . We examined international guidelines provided by different centers [14] and proposed a workflow based on the time points of the clinical course of COVID-19 disease in ESKD patients (Fig. 3) . abstract: The coronavirus disease 2019 (COVID-19) pandemic has caused a catastrophic global health crisis. There is a lack of mitigation and clinical management strategies for COVID-19 in specific patient cohorts such as hemodialysis (HD) patients. We report our experience in treating the first case of COVID-19 in a HD patient in Singapore who had a severe clinical course including acute respiratory distress syndrome and propose a clinical management strategy. We propose a clinical workflow in managing such patients based on available evidence from literature review. We also highlight the importance of early recognition and intervention for disease control, dialysis support in an acute hospital isolation facility, deisolation protocol, and discharge planning due to prolonged viral shedding. The case highlights important points specific to a HD patient with a COVID-19 diagnosis, tailored interventions for each stage of the disease, and deisolation considerations in the recovery phase. url: https://doi.org/10.1159/000509792 doi: 10.1159/000509792 id: cord-010141-955r29sd author: Sibila, Oriol title: Nonantibiotic Adjunctive Therapies for Community-Acquired Pneumonia (Corticosteroids and Beyond): Where Are We with Them? date: 2016-12-17 words: 4019.0 sentences: 213.0 pages: flesch: 37.0 cache: ./cache/cord-010141-955r29sd.txt txt: ./txt/cord-010141-955r29sd.txt summary: The purpose of this review is to assess the evidence related to corticosteroids and other nonantibiotic adjunctive therapies use and clinical outcomes in patients with CAP, with special interest in studies published in the last 10 years. These authors demonstrated a mortality reduction in the group treated with corticosteroids, a better modulation of systemic inflammatory response, and significant improvement in clinical endpoints, such as chest X-ray, multiple organ dysfunction syndrome severity scale, PaO 2 :FiO 2 ratio, and ICU and hospital stay. Our group demonstrated that acute administration of methylprednisolone (0.5 mg/kg/12 hours during 5 days) decrease treatment failure in a population of 120 patients with severe CAP who had high inflammatory response (defined as CRP greater than 150 mg/L on admission). Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial abstract: Community-acquired pneumonia (CAP) is a leading cause of hospitalization, morbidity, and mortality. Despite advances in antibiotic treatments, mortality among patients with CAP is still high. For this reason, interest has been focused on nonantibiotic therapeutic measures directed to the host response rather than the microorganism. The development of an efficacious adjunctive treatment has important implications for reducing mortality in CAP. Some clinical studies performed in the last decade have shown a clinically beneficial effect of corticosteroids, possibly by diminishing local and systemic inflammatory host response. Recent meta-analyses showed faster resolution of symptoms, shorter time to clinically stability, reduction of mechanical ventilation needed, and reduction of mortality in the most severe population, although some methodological limitations must be taken into account. In addition, some studies using statins also suggested improved outcomes due to its anti-inflammatory effect in CAP, although this requires further research. Other adjunctive therapies such as immunoglobulins and stem cells are being explored, but are not yet in the stage of clinical trials. In summary, the use of corticosteroids and other adjuvant treatments are promising in CAP, but more studies are needed to determine their impact on mortality. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171709/ doi: 10.1055/s-0036-1593538 id: cord-276234-2nkeq4ud author: Siedlecki, Jakob title: COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic date: 2020-05-06 words: 3702.0 sentences: 227.0 pages: flesch: 46.0 cache: ./cache/cord-276234-2nkeq4ud.txt txt: ./txt/cord-276234-2nkeq4ud.txt summary: Indeed, ophthalmologists seem to rank among the medical specialties with the highest risk for COVID-19 infection, probably due to close patient contact during examination, e.g., at the slit lamp [4] , and possible conjunctival involvement during the course of the disease [5, 6] . In this paper, a systematic review of current COVID-19 literature relevant for ophthalmological practice is performed, with a special focus on modes of transmission, the prevention thereof, structural adjustments of clinical care required during the pandemic, and possible ocular manifestations of this novel disease. The novel coronavirus SARS-CoV 2, currently causing the COVID-19 pandemic, has severe implications for ophthalmologybe it because the eyes represent an important route of infection, most probably through lacrimal drainage into the nasal mucosa, or because of ocular manifestations, which, even if rather rare, can represent the first symptoms of this novel disease [29] . abstract: Purpose To perform a systematic analysis of articles on the ophthalmological implications of the global COVID-19 pandemic. Methods PubMed.gov was searched for relevant articles using the keywords “COVID-19”, “coronavirus”, and “SARS-CoV-2” in conjunction with “ophthalmology” and “eye”. Moreover, official recommendations of ophthalmological societies were systematically reviewed, with a focus on the American Academy of Ophthalmology (AAO) and the Royal College of Ophthalmologists (RCOphth). Results As of April 16, 2020, in total, 21 peer-reviewed articles on the ophthalmological aspects of COVID-19 were identified. Of these, 12 (57.1%) were from Asia, 6 (28.6%) from the United States of America, and 3 (14.3%) from Europe. There were 5 (23.8%) original studies, 10 (47.6%) letters, 3 (14.2%) case reports, and 3 (14.2%) reviews. These articles could be classified into the topics “Modes and prevention of (ocular) transmission”, “Ophthalmological manifestations of COVID-19”, “Clinical guidance concerning ophthalmological practice during the COVID-19 pandemic”, and “Practical recommendations for clinical infrastructure”. Practical recommendations could be extracted from official statements of the AAO and the RCOphth. Conclusion Within a short period, a growing body of articles has started to elucidate the ophthalmological implications of COVID-19. As the eye can represent a route of infection (actively via tears and passively via the nasoacrimal duct), ophthalmological care has to undergo substantial modifications during this pandemic. In the eye, COVID-19 can manifest as keratoconjunctivitis. url: https://doi.org/10.1055/a-1164-9381 doi: 10.1055/a-1164-9381 id: cord-022103-4zk8i6qb author: Siegel, Jane D. title: Pediatric Healthcare Epidemiology date: 2017-07-18 words: 12633.0 sentences: 562.0 pages: flesch: 30.0 cache: ./cache/cord-022103-4zk8i6qb.txt txt: ./txt/cord-022103-4zk8i6qb.txt summary: A series of IPC guidelines have been developed and updated at varying intervals by the HICPAC/CDC, IDSA, Society for Healthcare Epidemiology of America (SHEA), American Academy of Pediatrics, Association for Professionals in Infection Control and Epidemiology, and others to provide evidence-based and rated recommendations for practices that are associated with reduced rates of HAIs, especially those infections associated with the use of medical devices and surgical procedures. (2) clinical microbiology laboratory services needed to support infection control outbreak investigations, including ability to perform molecular diagnostic testing; (3) data-mining programs and information technology specialists; (4) multidisciplinary programs to ensure judicious use of antimicrobial agents and control of resistance; (5) development of effective educational information for delivery to HCP, patients, families, and visitors; and (6) local and state health department resources for preparedness. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152479/ doi: 10.1016/b978-0-323-40181-4.00002-5 id: cord-276758-k2imddzr author: Siegel, Jane D. title: 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings date: 2007-12-07 words: 46228.0 sentences: 2479.0 pages: flesch: 35.0 cache: ./cache/cord-276758-k2imddzr.txt txt: ./txt/cord-276758-k2imddzr.txt summary: Activities currently assigned to ICPs in response to emerging challenges include (1) surveillance and infection prevention at facilities other than acute care hospitals (eg, ambulatory clinics, day surgery centers, LTCFs, rehabilitation centers, home care); (2) oversight of employee health services related to infection prevention (eg, assessment of risk and administration of recommended treatment after exposure to infectious agents, tuberculosis screening, influenza vaccination, respiratory protection fit testing, and administration of other vaccines as indicated, such as smallpox vaccine in 2003); (3) preparedness planning for annual influenza outbreaks, pandemic influenza, SARS, and bioweapons attacks; (4) adherence monitoring for selected infection control practices; (5) oversight of risk assessment and implementation of prevention measures associated with construction and renovation; (6) prevention of transmission of MDROs; (7) evaluation of new medical products that could be associated with increased infection risk (eg, intravenous infusion materials); (8) communication with the public, facility staff, and state and local health departments concerning infection control-related issues; and (9) participation in local and multicenter research projects. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/18068815/ doi: 10.1016/j.ajic.2007.10.007 id: cord-319805-b6ypt5d0 author: Siepmann, Timo title: Association of history of cerebrovascular disease with severity of COVID-19 date: 2020-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To determine whether a history of cerebrovascular disease (CVD) increases risk of severe coronavirus disease 2019 (COVID-19). METHODS: In a retrospective multicenter study, we retrieved individual data from in-patients treated March 1 to April 15, 2020 from COVID-19 registries of three hospitals in Saxony, Germany. We also performed a systematic review and meta-analysis following PRISMA recommendations using PubMed, EMBASE, Cochrane Library databases and bibliographies of identified papers (last search on April 11, 2020) and pooled data with those deriving from our multicenter study. Of 3762 records identified, 11 eligible observational studies of laboratory-confirmed COVID-19 patients were included in quantitative data synthesis. Risk ratios (RR) of severe COVID-19 according to history of CVD were pooled using DerSimonian and Laird random effects model. Between-study heterogeneity was assessed using Cochran’s Q and I2-statistics. Severity of COVID-19 according to definitions applied in included studies was the main outcome. Sensitivity analyses were conducted for clusters of studies with equal definitions of severity. RESULTS: Pooled analysis included data from 1906 laboratory-confirmed COVID-19 patients (43.9% females, median age ranging from 39 to 76 years). Patients with previous CVD had higher risk of severe COVID-19 than those without [RR 2.07, 95% confidence interval (CI) 1.52–2.81; p < 0.0001]. This association was also observed in clusters of studies that defined severe manifestation of the disease by clinical parameters (RR 1.44, 95% CI 1.22–1.71; p < 0.0001), necessity of intensive care (RR 2.79, 95% CI 1.83–4.24; p < 0.0001) and in-hospital death (RR 2.18, 95% CI 1.75–2.7; p < 0.0001). CONCLUSION: A history of CVD might constitute an important risk factor of unfavorable clinical course of COVID-19 suggesting a need of tailored infection prevention and clinical management strategies for this population at risk. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00415-020-10121-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32761508/ doi: 10.1007/s00415-020-10121-0 id: cord-302062-wqmynngg author: Sierra-Hidalgo, Fernando title: Large artery ischemic stroke in severe COVID-19 date: 2020-06-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32594301/ doi: 10.1007/s00415-020-09967-1 id: cord-260871-dtn5t8ka author: Silva, Marcus Tulius T. title: SARS-CoV-2: Should We Be Concerned about the Nervous System? date: 2020-07-17 words: 4110.0 sentences: 263.0 pages: flesch: 43.0 cache: ./cache/cord-260871-dtn5t8ka.txt txt: ./txt/cord-260871-dtn5t8ka.txt summary: Besides, several neurological manifestations had been described as complications of two other previous outbreaks of CoV diseases (SARS ad Middle East respiratory syndrome). Several neurological manifestations were described as complications of two other previous outbreaks of CoV diseases, namely, SARS and the Middle East respiratory syndrome (MERS). Stroke is one of the most frequent neurological diseases associated with SARS-CoV-2 infection, 8 and large-vessel stroke in younger patients was recently reported in five patients. Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the central nervous system abstract: The COVID-19 pandemic has proved to be an enormous challenge to the health of the world population with tremendous consequences for the world economy. New knowledge about COVID-19 is being acquired continuously. Although the main manifestation of COVID-19 is SARS, dysfunction in other organs has been described in the last months. Neurological aspects of COVID-19 are still an underreported subject. However, a plethora of previous studies has shown that human CoVs might be neurotropic, neuroinvasive, and neurovirulent, highlighting the importance of this knowledge by physicians. Besides, several neurological manifestations had been described as complications of two other previous outbreaks of CoV diseases (SARS ad Middle East respiratory syndrome). Therefore, we should be watchful, searching for early evidence of neurological insults and promoting clinical protocols to investigate them. Our objectives are to review the potential neuropathogenesis of this new CoV and the neurological profile of COVID-19 patients described so far. url: https://doi.org/10.4269/ajtmh.20-0447 doi: 10.4269/ajtmh.20-0447 id: cord-334002-irbpehts author: Silva, Michelle A title: Telehealth treatment engagement with Latinx populations during the COVID-19 pandemic date: 2020-10-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/33038976/ doi: 10.1016/s2215-0366(20)30419-3 id: cord-306062-g9hk1iq5 author: Silverman, Dustin A. title: Respiratory and pulmonary complications in head and neck cancer patients: Evidence‐based review for the COVID‐19 era date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Pulmonary complications and infections frequently affect patients with head and neck squamous cell carcinoma (HNSCC). Common characteristics can predispose these patients to the development of severe respiratory illness, which may be particularly relevant during the 2019 coronavirus disease (COVID‐19) pandemic. METHODS: A scoping review was performed to assess the impact of pulmonary comorbidities and adverse respiratory outcomes in HNSCC patients. RESULTS: Advanced age, history of tobacco and alcohol abuse, and cardiopulmonary comorbidities are significant risk factors for the development of adverse respiratory outcomes. Treatment toxicities from radiation or chemoradiation therapy significantly increase these risks. CONCLUSION: Respiratory complications are a frequent cause of morbidity and mortality among HNSCC patients, and the COVID‐19 pandemic may disproportionately affect this population. Interventions designed to decrease smoking and alcohol use, improve oral hygiene, and aggressively manage medical comorbidities are important to the long‐term management and health of these patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32343013/ doi: 10.1002/hed.26217 id: cord-325869-3mvjc805 author: Silvestris, Nicola title: A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave? date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: If we focus our attention on seven main features of COVID-19 infection (heterogeneity, fragility, lack of effective treatments and vaccines, “miraculous cures”, psychological suffering, deprivation, and globalization), we may establish parallelism with the challenges faced in the steep road to the understanding and treatment of neoplastic diseases. How the similarities between these two conditions can help us cope with the emergency effort represented by the management of cancer patients in the COVID-19 era, today and in the future? In a manner similar to the Cancer Moonshot initiative in the United States, we can hypothesize a multinational moonshot project towards the management of cancer patients during COVID-19 pandemic. In particular, we believe that the main road to elaborate meaningful scientific evidence is represented by the collection of all the data on COVID-19 and cancer comorbidity that are and will become available in cancer centers, coupled with the design of large clinical studies. To address this goal, it is essential to identify the entity that can produce this scientific evidences and the potentially most successful research strategy to undertake. The largest Italian organization for cancer research, Alliance Against Cancer (Alleanza Contro il Cancro, ACC), is called to play a scientific leadership in addressing these challenges, which requires the coordination of oncology teams at regional, national, and international levels. To fulfill this commitment, ACC will create a liaison with health government agencies in order to develop “dynamic” indications able to fight such an unpredictable pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32522223/ doi: 10.1186/s13046-020-01614-x id: cord-284944-hcgfe9wv author: Silvin, Aymeric title: Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19 date: 2020-08-05 words: 10781.0 sentences: 503.0 pages: flesch: 46.0 cache: ./cache/cord-284944-hcgfe9wv.txt txt: ./txt/cord-284944-hcgfe9wv.txt summary: Thus, we performed high dimensional flow cytometry and single cell RNA sequencing of COVID-19 patient peripheral blood cells and detected the disappearance of non-classical CD14LowCD16High monocytes, the accumulation of HLA-DRLow classical monocytes, and the release of massive amounts of calprotectin (S100A8/S100A9) in severe cases. Validating these discovery experiments, we performed mass cytometry analysis of an independent cohort of 12 patients (four in each group; control, mild and severe) ( Table S5) , which showed a lower fraction of CD14 Low CD16 High non-classical monocytes in severe compared to mild patients ( Figure 3F and 3G ). This study presents evidence that patients who develop a severe COVID-19 exhibit high levels of calprotectin and inflammatory cytokines and chemokines correlating with an emergency myelopoiesis generating ROS-and NOS-expressing immunosuppressive myeloid cells (HLA-DR Low monocytes and immature subsets of neutrophils). abstract: Summary Blood myeloid cells are known to be dysregulated in the coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2. It is unknown whether the innate myeloid response differs with disease severity, and whether markers of innate immunity discriminate high risk patients. Thus, we performed high dimensional flow cytometry and single cell RNA sequencing of COVID-19 patient peripheral blood cells and detected the disappearance of non-classical CD14LowCD16High monocytes, the accumulation of HLA-DRLow classical monocytes, and the release of massive amounts of calprotectin (S100A8/S100A9) in severe cases. Immature CD10LowCD101-CXCR4+/- neutrophils with an immuno-suppressive profile accumulated as well in blood and lungs, suggesting emergency myelopoiesis. We finally showed that calprotectin plasma level and a routine flow cytometry assay detecting decreased frequencies of non-classical monocytes could discriminate patients who develop a severe COVID-19 form, suggesting a predictive value that deserves prospective evaluation. url: https://www.sciencedirect.com/science/article/pii/S0092867420309934?v=s5 doi: 10.1016/j.cell.2020.08.002 id: cord-310177-4jw1lkli author: Simcock, R. title: Beyond Performance Status date: 2020-07-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Oncologists should recognise the need to move beyond the Eastern Cooperative Oncology Group Performance Status (ECOG PS) score. ECOG PS is a longstanding and ubiquitous feature of oncology. It was evolved 40 years ago as an adaption of the 70-year-old Karnofsky performance score. It is short, easily understood and part of the global language of oncology. The wide prevalence of the ECOG PS attests to its proven utility and worth to help triage patient treatment. The ECOG PS is problematic. It is a unidimensional functional score. It is mostly physician assessed, subjective and therefore open to bias. It fails to account for multimorbidity, frailty or cognition. Too often the PS is recorded only once in wilful ignorance of a patient's changing physical state. As modern oncology offers an ever-widening array of therapies that are ‘personalised’ to tumour genotype, modern oncologists must strive to better define patient phenotype. Using a wider range of scoring and assessment tools, oncologists can identify deficits that may be reversed or steps taken to mitigate detrimental effects of treatment. These tools can function well to identify those patients who would benefit from comprehensive assessment. This overview identifies the strengths of ECOG PS but highlights the weaknesses and where these are supported by other measures. A strong recommendation is made here to move to routine use of the Clinical Frailty Score to start to triage patients and most appropriately design treatments and rehabilitation interventions. url: https://doi.org/10.1016/j.clon.2020.06.016 doi: 10.1016/j.clon.2020.06.016 id: cord-355589-3zdv9zim author: Simons, David title: The association of smoking status with SARS‐CoV‐2 infection, hospitalisation and mortality from COVID‐19: A living rapid evidence review with Bayesian meta‐analyses (version 7) date: 2020-10-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: AIMS: To estimate the association of smoking status with rates of i) infection, ii) hospitalisation, iii) disease severity, and iv) mortality from SARS‐CoV‐2/COVID‐19 disease. DESIGN: Living rapid review of observational and experimental studies with random‐effects hierarchical Bayesian meta‐analyses. Published articles and pre‐prints were identified via MEDLINE and medRxiv. SETTING: Community or hospital. No restrictions on location. PARTICIPANTS: Adults who received a SARS‐CoV‐2 test or a COVID‐19 diagnosis. MEASUREMENTS: Outcomes were SARS‐CoV‐2 infection, hospitalisation, disease severity and mortality stratified by smoking status. Study quality was assessed (i.e. ‘good’, ‘fair’ and ‘poor’). FINDINGS: Version 7 (searches up to 25 August 2020) included 233 studies with 32 ‘good’ and ‘fair’ quality studies included in meta‐analyses. Fifty‐seven studies (24.5%) reported current, former and never smoking status. Recorded smoking prevalence among people with COVID‐19 was generally lower than national prevalence. Current compared with never smokers were at reduced risk of SARS‐CoV‐2 infection (RR=0.74, 95% Credible Interval (CrI) = 0.58‐0.93, τ = 0.41). Data for former smokers were inconclusive (RR=1.05, 95% CrI = 0.95‐1.17, τ = 0.17) but favoured there being no important association (21% probability of RR ≥1.1). Former compared with never smokers were at somewhat increased risk of hospitalisation (RR=1.20, CrI = 1.03‐1.44, τ = 0.17), greater disease severity (RR=1.52, CrI = 1.13‐2.07, τ = 0.29), and mortality (RR=1.39, 95% CrI = 1.09‐1.87, τ = 0.27). Data for current smokers were inconclusive (RR=1.06, CrI = 0.82‐1.35, τ = 0.27; RR=1.25, CrI = 0.85‐1.93, τ = 0.34; RR=1.22, 95% CrI = 0.78‐1.94, τ = 0.49 respectively) but favoured there being no important associations with hospitalisation and mortality (35% and 70% probability of RR ≥1.1, respectively) and a small but important association with disease severity (79% probability of RR ≥1.1). CONCLUSIONS: Compared with never smokers, current smokers appear to be at reduced risk of SARS‐CoV‐2 infection while former smokers appear to be at increased risk of hospitalisation, increased disease severity and mortality from COVID‐19. However, it is uncertain whether these associations are causal. url: https://doi.org/10.1111/add.15276 doi: 10.1111/add.15276 id: cord-340383-psjga23p author: Simpson, Brenda Baird title: Patient Care Services Staffing Support During a Pandemic date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Providing adequate staff during a pandemic requires the creative use of all human resources from within the organization and from outside agencies offering assistance. With the use of all possible resources, clinical RNs are better supported at the bedside as they provide safe patient care. Defined processes provide clear information to staff regarding available human resources and their appropriate use. url: https://www.sciencedirect.com/science/article/pii/S1541461220302019 doi: 10.1016/j.mnl.2020.07.005 id: cord-341591-ib8lsvku author: Simpson, J. Keith title: Informed consent, duty of disclosure and chiropractic: where are we? date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The COVID-19 pandemic has seen the emergence of unsubstantiated claims by vertebral subluxation-based chiropractors that spinal manipulative therapy has a role to play in prevention by enhancing the body’s immune function. We contend that these claims are unprofessional and demonstrate a disturbing lack of insight into the doctrine of informed consent. As such it is timely to review how informed consent has evolved and continues to do so and also to discuss the attendant implications for contemporary health practitioner practice. We review the origins of informed consent and trace the duty of disclosure and materiality through landmark medical consent cases in four common law (case law) jurisdictions. The duty of disclosure has evolved from a patriarchal exercise to one in which patient autonomy in clinical decision making is paramount. Passing time has seen the duty of disclosure evolve to include non-medical aspects that may influence the delivery of care. We argue that a patient cannot provide valid informed consent for the removal of vertebral subluxation. Further, vertebral subluxation care cannot meet code of conduct standards because it lacks an evidence base and is practitioner-centered. The uptake of the expanded duty of disclosure has been slow and incomplete by practitioners and regulators. The expanded duty of disclosure has implications, both educative and punitive for regulators, chiropractic educators and professional associations. We discuss how practitioners and regulators can be informed by other sources such as consumer law. For regulators, reviewing and updating informed consent requirements is required. For practitioners it may necessitate disclosure of health status, conflict of interest when recommending “inhouse” products, recency of training after attending continuing professional development, practice patterns, personal interests and disciplinary findings. CONCLUSION: Ultimately such matters are informed by the deliberations of the courts. It is our opinion that the duty of a mature profession to critically self-evaluate and respond in the best interests of the patient before these matters arrive in court. url: https://www.ncbi.nlm.nih.gov/pubmed/33148281/ doi: 10.1186/s12998-020-00342-5 id: cord-284576-nemh4wdo author: Sims, Jonathan T. title: Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19 date: 2020-09-10 words: 1643.0 sentences: 91.0 pages: flesch: 42.0 cache: ./cache/cord-284576-nemh4wdo.txt txt: ./txt/cord-284576-nemh4wdo.txt summary: Methods Blood samples from adult patients hospitalized with COVID-19 were analyzed using high-throughput and ultrasensitive proteomic platforms and compared with ageand sex-matched healthy controls to provide insights into differential regulation of 185 markers. Objective: To identify and characterize the host inflammatory response to SARS-CoV-2 59 infection, we assessed levels of proteins related to immune responses and cardiovascular 60 disease, in patients stratified as mild, moderate, and severe, versus matched healthy controls. Objective: To identify and characterize the host inflammatory response to SARS-CoV-2 59 infection, we assessed levels of proteins related to immune responses and cardiovascular 60 disease, in patients stratified as mild, moderate, and severe, versus matched healthy controls. Furthermore, in a limited series of patients who were sampled 69 frequently confirming reliability and reproducibility of our assays, we demonstrate that 70 intervention with baricitinib attenuates these circulating biomarkers associated with the cytokine 71 The COVID-19 pandemic created an overwhelming need to define host-derived molecular 96 mediators of disease severity evident in hospitalized patients. abstract: Background Physicians treating COVID-19 patients increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a cytokine storm. The circulating biomarkers seen across the spectrum of COVID-19 have not been characterized compared to healthy controls, but such analyses are likely to yield insights into the pursuit of interventions that adequately reduce the burden of these cytokine storms. Objective To identify and characterize the host inflammatory response to SARS-CoV-2 infection, we assessed levels of proteins related to immune responses and cardiovascular disease, in patients stratified as mild, moderate, and severe, versus matched healthy controls. Methods Blood samples from adult patients hospitalized with COVID-19 were analyzed using high-throughput and ultrasensitive proteomic platforms and compared with age- and sex-matched healthy controls to provide insights into differential regulation of 185 markers. Results Results indicate a dominant hyperinflammatory milieu in the circulation and vascular endothelial damage markers within COVID-19 patients, and strong biomarker association with patient response as measured by Ordinal scale. As patients progress, we observe statistically significant dysregulation of IFNγ, IL-1RA, IL-6, IL-10, IL-19, MCP-1, -2, -3, CXCL9, CXCL10, CXCL5, ENRAGE and PARP-1. Furthermore, in a limited series of patients who were sampled frequently confirming reliability and reproducibility of our assays, we demonstrate that intervention with baricitinib attenuates these circulating biomarkers associated with the cytokine storm. Conclusion These wide-ranging circulating biomarkers show an association with increased disease severity and may help stratify patients and selection of therapeutic options. They also provide insights into mechanisms of SARS-CoV-2 pathogenesis and the host response. url: https://doi.org/10.1016/j.jaci.2020.08.031 doi: 10.1016/j.jaci.2020.08.031 id: cord-271871-8grkln6o author: Singer, J. S. title: Low Prevalence (0.13%) of COVID-19 Infection in Asymptomatic Pre-operative/Pre-procedure Patients at a Large Academic Medical Center Informs Approaches to Perioperative Care date: 2020-08-14 words: 2842.0 sentences: 158.0 pages: flesch: 43.0 cache: ./cache/cord-271871-8grkln6o.txt txt: ./txt/cord-271871-8grkln6o.txt summary: Abstract Background The COVID-19 pandemic has resulted in reduced performance of elective surgeries and procedures at medical centers across the U.S. Awareness of the prevalence of asymptomatic disease is critical for guiding safe approaches to operative/procedural services. Conclusions These data demonstrating low levels (0.13% prevalence) of COVID-19 infection in an asymptomatic population of patients undergoing scheduled surgeries/procedures in a large urban area have helped to inform perioperative protocols during the COVID-19 pandemic. These data demonstrating low levels (0.13% prevalence) of COVID-19 infection in an asymptomatic 117 population of patients undergoing scheduled surgeries/procedures in a large urban area have helped to 118 inform perioperative protocols during the COVID-19 pandemic. As a large urban referral center, we adopted the CDC and ACS recommendations early in the pandemic, 327 suspending elective surgical and interventional procedures, and later relaxing those suspensions while 328 balancing local/regional COVID-19 epidemiology, data regarding our pre-operative/pre-procedure 329 testing results, and health system resources and priorities. abstract: Abstract Background The COVID-19 pandemic has resulted in reduced performance of elective surgeries and procedures at medical centers across the U.S. Awareness of the prevalence of asymptomatic disease is critical for guiding safe approaches to operative/procedural services. As COVID-19 PCR testing has been limited largely to symptomatic patients, healthcare workers (HCWs), or to those in communal care centers, data regarding asymptomatic viral disease carriage are limited. Study Design In this retrospective observational case series evaluating UCLA Health patients enrolled in pre-operative/pre-procedure protocol COVID-19 RT-PCR testing between 4/7/20 – 5/21/20, we determine the prevalence of COVID-19 infection in asymptomatic patients scheduled for surgeries and procedures. Results Primary outcomes include the prevalence of COVID-19 infection in this asymptomatic population. Secondary data analysis includes overall population testing results and population demographics. 18 of 4751 (0.38%) patients scheduled for upcoming surgeries and high risk procedures had abnormal (positive/inconclusive) COVID-19 RT-PCR testing results. 6/18 patients were confirmed asymptomatic. 4/18 had inconclusive results. 8/18 had positive results in the setting of recent symptoms or known COVID-19 infection. The prevalence of asymptomatic COVID-19 infection was 0.13%. More than 90% of patients had residential addresses within a 67 mile geographic radius of our medical center, the median age was 58, and there was equal male/female distribution. Conclusions These data demonstrating low levels (0.13% prevalence) of COVID-19 infection in an asymptomatic population of patients undergoing scheduled surgeries/procedures in a large urban area have helped to inform perioperative protocols during the COVID-19 pandemic. Testing protocols like ours may prove valuable for other health systems in their approaches to safe procedural practices during COVID-19. url: http://www.surgjournal.com/article/S0039606020305213/pdf doi: 10.1016/j.surg.2020.07.048 id: cord-305498-8tmtvw1r author: Singh Saraj, K. title: Modification of Neurosurgical Practice during Corona Pandemic: Our Experience at AIIMS Patna And Long Term Guidelines date: 2020-09-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: First case of covid-19 was confirmed on 30(th) January, 2020 in India. Our state, Bihar reported its first confirmed case of covid on 22(nd) march 2020 at AIIMS Patna. For safety, Electives surgeries and outpatient department was suspended temporary since 25(th) March. Standard operating procedure (SOP) was framed for covid suspected, covid positive and negative patients. Neurosurgery department formulated their own strategy for successful and covid free management of neurosurgical patients along with zero transmission rate among doctors and staff. METHODS: All Neurosurgical patients who got attended, admitted and operated from 25(th) March to 30(th) June 2020 (Period of lockdown) were taken in this study. Categorizations of the patients were done according to the urgency and elective nature of pathology after corona screening and RT-PCR testing of covid-19. A proper training to all neurosurgical staff and residents were given for management of patients (admission to operation to discharge). RESULTS: Total 133 patients were attended and 90 were admitted. We operated 76 cases (major -52, minor – 24) during the lockdown period. Out of this 2 were corona positive (both eventually succumbed) and rest 74 was corona negative. One patient who was operated with corona negative report became positive after 10 days of surgery inward. All the residents, faculty and nursing staff remain asymptomatic throughout the lockdown period with zero infection rate and zero transmission rate. CONCLUSION: Following a properly made standard operating procedure and strictly implementing it can avoid any type of misadventure in neurosurgery during corona pandemic. KEY MESSAGE: Adequate planning and sufficient training is necessary to avoid any untoward incident of infection. Proper utilization of limited human resources and infectious kit is needed at this time. url: https://www.sciencedirect.com/science/article/pii/S2214751920304564?v=s5 doi: 10.1016/j.inat.2020.100895 id: cord-009507-l74c9x0n author: Singh, Amandeep title: Clinicopathological Conference: Fever, Productive Cough, and Tachycardia in a 22‐year‐old Asian Male date: 2008-01-08 words: 4395.0 sentences: 291.0 pages: flesch: 42.0 cache: ./cache/cord-009507-l74c9x0n.txt txt: ./txt/cord-009507-l74c9x0n.txt summary: To generate the appropriate differential diagnosis in this case, there are several key features of the patient''s history and physical examination that aid in the understanding of his pathologic process: 1) symptom development occurred soon after emigration from Indonesia, 2) the patient''s primary symptoms were pulmonary in origin, and 3) secondary cardiac involvement resulted in a large, initially asymptomatic pericardial effusion. 10 Acute infection begins with sudden onset of one or more of the following: high fevers (up to 104-1058F), severe headache, general malaise, myalgia, confusion, sore throat, chills, sweats, nonproductive cough, nausea, vomiting, diarrhea, abdominal pain, and chest pain. In our patient, the most likely cause of the pericardial effusion was infection with tuberculosis. To summarize, this patient''s recent immigration, symptoms of intermittent fever and of chronic cough that failed to respond to outpatient antibiotics, and development of large pericardial effusion all are consistent with a diagnosis of tuberculosis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159384/ doi: 10.1111/j.1553-2712.2004.tb01429.x id: cord-265934-wjdxqj8h author: Singh, Amrita K. title: A Review of Telemedicine Applications in Otorhinolaryngology: Considerations During the Coronavirus Disease of 2019 Pandemic date: 2020-10-01 words: 4195.0 sentences: 282.0 pages: flesch: 40.0 cache: ./cache/cord-265934-wjdxqj8h.txt txt: ./txt/cord-265934-wjdxqj8h.txt summary: 21 Recent studies on remote free flap monitoring provide clear examples of how telemedicine can not only expedite care, but also improve patient outcomes. There is a further need for controlled studies comparing telemedicine to in-person assessment of head and neck cancer patients in terms of cost, safety, surveillance adherence, and oncologic outcomes. published clinical practice guidelines for the management of dysphagia in the COVID-19 pandemic, suggesting use of telemedicine for triage and remote evaluation. 63 High levels of patient satisfaction were also achieved with smartphone-based follow-up of facial cosmetic surgery and reviewing images remotely. Telemedicine has a wide applicability in pediatric ORL for obtaining patient history and assessing need for common surgeries such as obstructive sleep apnea, recurrent tonsillitis, and recurrent otitis media (Table VII) . Utilization of SAF techniques have already proven useful in head and neck oncology consultations, remote otologic and audiologic evaluation, cochlear implant and hearing aid management, laryngeal ultrasonography, nasolaryngoscopy, as well as CT sinus review. abstract: OBJECTIVE/HYPOTHESIS: Review the published literature of telemedicine's use within otorhinolaryngology (ORL), highlight its successful implementation, and document areas with need of future research. STUDY DESIGN: State of the Art Review. METHODS: Three independent, comprehensive searches for articles published on the subject of telemedicine in ORL were conducted of literature available from January 2000 to April 2020. Search terms were designed to identify studies which examined telemedicine use within ORL. Consensus among authors was used to include all relevant articles. RESULTS: While several, small reports document clinical outcomes, patient satisfaction, and the cost of telemedicine, much of the literature on telemedicine in ORL is comprised of preliminary, proof‐of‐concept reports. Further research will be necessary to establish its strengths and limitations. CONCLUSIONS: Particularly during the coronavirus disease of 2019 pandemic, telemedicine can, and should, be used within ORL practice. This review can assist in guiding providers in implementing telemedicine that has been demonstrated to be successful, and direct future research. Laryngoscope, 2020 url: https://www.ncbi.nlm.nih.gov/pubmed/32942340/ doi: 10.1002/lary.29131 id: cord-289114-ifnk41oq author: Singh, Angaraj title: Effect of pre‐existing diseases on COVID‐19 infection and role of new sensors and biomaterials for its detection and treatment date: 2020-10-28 words: 6894.0 sentences: 470.0 pages: flesch: 54.0 cache: ./cache/cord-289114-ifnk41oq.txt txt: ./txt/cord-289114-ifnk41oq.txt summary: The SARS-CoV-2 infected patients with the cardiovascular problem have a higher fatality rate as compared to general COVID-19 patients. The ACE-2 has been suggested as a medicine for the treatment of diabetes because it reduces inflammation .Therefore, the diabetes and COVID-19 patients treated with ACE-2 have higher risk of infection (Zachary, 2020) . Although, the specific drug for SARS-CoV-2 is not discovered till date, the medical observers are attempting with different antiviral drugs for the treatment of COVID-19 infection . All rights reserved patients demonstrated that the combination of a new antiviral drug remdesivir and chloroquine slowed down the growth of SARS-CoV-2 (Abdul et al., 2017) . Convalescent plasma therapy has been observed as a better alternative for the treatment of severely infected COVID-19 patients. A research report suggested that plasma treatment is more effective at the initial stage (within 14 days of symptoms) of COVID-19 infection. abstract: The entire world is suffering from a new type of viral disease, occurred by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). The present article briefly discussed the genome sequencing and interaction of host cells with SARS‐CoV‐2. The influence of pre‐existing diseases such as diabetes, heart disease and age of the patients on COVID‐19 infection is reviewed. The possible treatments of SARS‐CoV‐2 including antiviral drugs, Chinese traditional treatment and plasma therapy are elaborately discussed. The proper vaccine for COVID‐19 is not available till date. However, the trials of pre‐existing antiviral vaccines such as, chloroquine/hydroxychloroquine, remdesivir, ritonavir and lopinavir and their consequences are briefly presented. Further, the importance of new materials and devices for the detection and treatment of COVID‐19 has also been reviewed. The polymerase chain reaction (PCR)‐based, and non‐PCR based devices are used for the detection of COVID‐19 infection. The non‐PCR based devices provide rapid results as compared to PCR based devices. url: https://www.ncbi.nlm.nih.gov/pubmed/33173852/ doi: 10.1002/mds3.10140 id: cord-286638-bqxyb61p author: Singh, Awadhesh Kumar title: Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations date: 2020-04-09 words: 4824.0 sentences: 281.0 pages: flesch: 46.0 cache: ./cache/cord-286638-bqxyb61p.txt txt: ./txt/cord-286638-bqxyb61p.txt summary: The disease burden of coronavirus infectious disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) has been increasing continuously with more than a million confirmed patients and more than 45 thousand deaths globally [1] . Emerging data suggests that COVID-19 is common in patients with diabetes, hypertension, and cardiovascular disease (CVD), although the prevalence rate varied in different studies as well in country-wise data. Evolving data also suggest that patients of COVID-19 with diabetes are more often associated with severe or critical disease varying from 14 to 32% in different studies [15e18, 20, 22, 24] . Though there is limited data about the association of blood glucose levels with disease course in COVID-19 at present, data from other infections like SARS and influenza H1N1 has shown that patients with poor glycemic control have increased risk of complications and death [60, 61] . abstract: BACKGROUND AND AIMS: High prevalence of diabetes makes it an important comorbidity in patients with COVID-19. We sought to review and analyze the data regarding the association between diabetes and COVID-19, pathophysiology of the disease in diabetes and management of patients with diabetes who develop COVID-19 infection. METHODS: PubMed database and Google Scholar were searched using the key terms ‘COVID-19’, ‘SARS-CoV-2’, ‘diabetes’, ‘antidiabetic therapy’ up to April 2, 2020. Full texts of the retrieved articles were accessed. RESULTS: There is evidence of increased incidence and severity of COVID-19 in patients with diabetes. COVID-19 could have effect on the pathophysiology of diabetes. Blood glucose control is important not only for patients who are infected with COVID-19, but also for those without the disease. Innovations like telemedicine are useful to treat patients with diabetes in today’s times. url: https://doi.org/10.1016/j.dsx.2020.04.004 doi: 10.1016/j.dsx.2020.04.004 id: cord-323816-3m1iu9j2 author: Singh, Awadhesh Kumar title: Impact of COVID-19 and comorbidities on health and economics: Focus on developing countries and India date: 2020-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND AND AIMS: Presence of comorbidities in patients with Coronavirus disease 2019 (COVID-19) have often been associated with increased in-hospital complications and mortality. Intriguingly, several developed countries with a higher quality of life have relatively higher mortality with COVID-19, compared to the middle- or low-income countries. Moreover, certain ethnic groups have shown a higher predilection to contract COVID-19, with heightened mortality. We sought to review the available literature with regards to impact of COVID-19 and comorbidities on the health and economics, especially in context to the developing countries including India. METHODS: A Boolean search was carried out in PubMed, MedRxiv and Google Scholar databases up till August 23, 2020 using the specific keywords to find the prevalence of comorbidities and its outcome in patients with COVID-19. RESULTS: All available evidence consistently suggests that presence of comorbidities is associated with a poor outcome in patients with COVID-19. Diabetes prevalence is highest in Indian COVID-19 patients compared to other countries. Majority of the patients with COVID-19 are asymptomatic ranging from 26 to 76%. CONCLUSIONS: Universal masking is the need of hour during unlock period. Low-income countries such as India, Brazil and Africa with less resources and an average socio-economic background, must adopt a strict policy for an affordable testing programs to trace, test, identify and home quarantine of asymptomatic cases. Despite the huge number of COVID-19 patients, India still has low volume research at the moment. url: https://www.ncbi.nlm.nih.gov/pubmed/32891011/ doi: 10.1016/j.dsx.2020.08.032 id: cord-010566-tciwtxud author: Singh, Nina title: Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality date: 1998 words: 3672.0 sentences: 182.0 pages: flesch: 40.0 cache: ./cache/cord-010566-tciwtxud.txt txt: ./txt/cord-010566-tciwtxud.txt summary: Determinants of outcome and the utility of the Child-Pugh score and the acute physiology and chronic health evaluation (APACHE) II score as predictors of outcome were prospectively assessed in 54 consecutive patients with cirrhosis requiring intensive care unit (ICU) management. 9,10 Acute physiology and chronic health evaluation (APACHE) scores were determined to be of prognostic significance in a study in ICU patients with cirrhosis; however, neither Child-Pugh scores nor etiology of liver disease were assessed in that study. 35 Mental status has been shown to be a significant predictor of outcome in ICU patients in a number of clinical settings, e.g., patients with acute renal failure requiring dialysis and transplant recipients. Although Child-Pugh scores, serum bilirubin, creatinine, or the incidence of gastrointestinal bleeding was not different, the patients with liver disease not caused by alcohol may have been more debilitated, as indicated by a significantly greater requirement for mechanical ventilation and a higher incidence of pulmonary infiltrates. abstract: Determinants of outcome and the utility of the Child-Pugh score and the acute physiology and chronic health evaluation (APACHE) II score as predictors of outcome were prospectively assessed in 54 consecutive patients with cirrhosis requiring intensive care unit (ICU) management. Overall mortality in the ICU was 43% (23/54). Child-Pugh scores did not differ between survivors or nonsurvivors (12.8 versus 12.3, P = 0.26), however APACHE II scores (P = 0.007), acute physiology scores (P = 0.006), and Karnofsky scores (P = 0.001) were significant predictors of outcome. By univariate analysis, requirement of mechanical ventilation analysis (P = 0.001), duration of mechanical ventilation (P = 0.001), pulmonary infiltrates (P = 0.0001), infections (P = 0.047), gastrointestinal bleeding (P = 0.005), and serum creatinine ≥1.5 mg/dl (P = 0.0005) were significantly associated with mortality. By logistic regression analysis only pulmonary infiltrates (P = 0.0001) and renal dysfunction (P = 0.041) were independent predictors of mortality. When controlled for the severity of illness (APACHE II scores), the mortality in patients with cirrhosis caused by alcohol was significantly lower than that in patients with liver disease not caused by alcohol (P = 0.01). Our study not only identified predictors of poor outcome in patients with cirrhosis requiring ICU care but also provided data that may have implications for optimal timing for transplantation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197333/ doi: 10.1007/s005350050047 id: cord-305076-v56y5nyt author: Singh, Parmvir title: Disseminated Intravascular Coagulation: A Devastating Systemic Disorder of Special Concern with COVID‐19 date: 2020-07-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Disseminated intravascular coagulation (DIC) is linked with severe COVID‐19, prompting considerable concern. DIC can be a devastating systemic disorder. It is often markedly manifest on the skin as acrocyanosis or as petechiae and purpura with progression to hemorrhagic bullae. Subcutaneous hematomas may occur, as may thrombotic findings including necrosis and gangrene. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32700813/ doi: 10.1111/dth.14053 id: cord-314378-cs9ggqwk author: Singh, Prateush title: The Effects of a Novel Global Pandemic (COVID-19) on a Plastic Surgery Department date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32347920/ doi: 10.1093/asj/sjaa074 id: cord-264327-uzlavmhx author: Singh, Rajat title: Novel Coronavirus Disease 2019 in a Patient on Durable Left Ventricular Assist Device Support date: 2020-04-17 words: 882.0 sentences: 59.0 pages: flesch: 44.0 cache: ./cache/cord-264327-uzlavmhx.txt txt: ./txt/cord-264327-uzlavmhx.txt summary: To the best of our knowledge, we present here the first confirmed case of COVID-19 in a patient on left ventricular assist device (LVAD) support. In the following days, the patient developed progressive hypotension requiring initiation of vasopressor agents, acute oliguric renal failure requiring continuous renal replacement therapy, and refractory hypoxemia consistent with acute respiratory distress syndrome (ARDS). While it has previously been shown that prone positioning unloads the right ventricle in ARDS due to improved pulmonary pressures, (1) the use of this maneuver in the setting of LVAD has not been well described and may be adversely associated with increase in RV pressures and subsequent RV failure. This report describes the first known presentation of illness secondary to SARS-CoV-2 in a patient with long-term LVAD support. Cellular immunity impaired among patients on left ventricular assist device for 6 months abstract: nan url: https://doi.org/10.1016/j.cardfail.2020.04.007 doi: 10.1016/j.cardfail.2020.04.007 id: cord-336336-f01khqqr author: Singh, Rajat title: Therapeutic Strategy for Coronavirus Disease 2019 in Patients on Durable Left Ventricular Assist Device Support date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1071916420305133?v=s5 doi: 10.1016/j.cardfail.2020.05.001 id: cord-290551-a02tueuu author: Singh, Shailendra title: Impact of Obesity on Outcomes of Patients with COVID-19 in United States: A Multicenter Electronic Health Records Network Study. date: 2020-08-21 words: 2708.0 sentences: 157.0 pages: flesch: 54.0 cache: ./cache/cord-290551-a02tueuu.txt txt: ./txt/cord-290551-a02tueuu.txt summary: title: Impact of Obesity on Outcomes of Patients with COVID-19 in United States: A Multicenter Electronic Health Records Network Study. We performed a retrospective cohort study using TriNetX (Cambridge, MA, USA), a global federated health research network that provided access to electronic medical records of patients from multiple large member healthcare organizations (HCOs) in United States. Our study using a large nationally representative database showed that COVID-19 patients with any degree of obesity had a significantly higher risk of hospitalization and intubation or death compared to patients without obesity. An analysis of a larger group of selected patients using diagnostic criteria of obesity as any time before the index event (after PSM n=9769) showed a higher risk for composite outcomes in the obesity group ( J o u r n a l P r e -p r o o f abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32835663/ doi: 10.1053/j.gastro.2020.08.028 id: cord-336554-n8n5ii5k author: Singh, Thakur Uttam title: Drug repurposing approach to fight COVID-19 date: 2020-09-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Currently, there are no treatment options available for the deadly contagious disease, coronavirus disease 2019 (COVID-19). Drug repurposing is a process of identifying new uses for approved or investigational drugs and it is considered as a very effective strategy for drug discovery as it involves less time and cost to find a therapeutic agent in comparison to the de novo drug discovery process. The present review will focus on the repurposing efficacy of the currently used drugs against COVID-19 and their mechanisms of action, pharmacokinetics, dosing, safety, and their future perspective. Relevant articles with experimental studies conducted in-silico, in-vitro, in-vivo, clinical trials in humans, case reports, and news archives were selected for the review. Number of drugs such as remdesivir, favipiravir, ribavirin, lopinavir, ritonavir, darunavir, arbidol, chloroquine, hydroxychloroquine, tocilizumab and interferons have shown inhibitory effects against the SARS-CoV2 in-vitro as well as in clinical conditions. These drugs either act through virus-related targets such as RNA genome, polypeptide packing and uptake pathways or target host-related pathways involving angiotensin-converting enzyme-2 (ACE2) receptors and inflammatory pathways. Using the basic knowledge of viral pathogenesis and pharmacodynamics of drugs as well as using computational tools, many drugs are currently in pipeline to be repurposed. In the current scenario, repositioning of the drugs could be considered the new avenue for the treatment of COVID-19. url: https://doi.org/10.1007/s43440-020-00155-6 doi: 10.1007/s43440-020-00155-6 id: cord-317265-n6x0r58i author: Singh, Varsha title: Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease? date: 2020-07-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: The highly infectious transmissible disease, the novel SARS-CoV-2, causing the coronavirus disease (COVID-19), has a median incubation time of 5 to 15 days. The symptoms vary from person to person and many are “hidden carriers.” Few people experience immediate reaction and even death within 48 h of infection. However, many show mild to chronic symptoms and recover. Nevertheless, the death rate due to COVID-19 transmission is high especially among patients with non-communicable diseases. The purpose of this review is to provide evidence to consider vitamins as epigenetic modifiers to enhance immunity and reduce inflammatory response in COVID-19 patients with non-communicable diseases. RECENT FINDINGS: Clinical evidence has suggested the risk of getting infected is high among individuals with non-communicable diseases such as cardiovascular disease, type-2 diabetes, cancer, acute respiratory distress syndrome, and renal disease, as well as the elderly with high mortality rate among the cohort. The impact is due to an already compromised immune system of patients. Every patient has a different response to COVID-19, which shows that the ability to combat the deadly virus varies individually. Thus, treatment can be personalized and adjusted to help protect and combat COVID-19 infections, especially in individuals with non-communicable diseases. SUMMARY: Based on current published scientific and medical evidence, the suggestions made in this article for combination of vitamin therapy as epigenetic modifiers to control the unregulated inflammatory and cytokine marker expressions, further needs to be clinically proven. Future research and clinical trials can apply the suggestions given in this article to support metabolic activities in patients and enhance the immune response. url: https://doi.org/10.1007/s13668-020-00330-4 doi: 10.1007/s13668-020-00330-4 id: cord-262998-cugd2t1l author: Singh, Vishwendra title: The novel coronavirus and challenges for general and paediatric dentists date: 2020-05-02 words: 1325.0 sentences: 83.0 pages: flesch: 48.0 cache: ./cache/cord-262998-cugd2t1l.txt txt: ./txt/cord-262998-cugd2t1l.txt summary: Frequent hand washing lasting at least 20 s with soap and water, use of hand sanitizers with at least 60% alcohol, avoiding touching mucosal surfaces (mouth, nose, eyes) with unwashed hands, practicing proper cough etiquette, wearing a face mask (if symptomatic), limiting exposure to affected people and maintaining a distance of at least 2 m from others are the suggested preventive steps [1] . It is therefore imperative that guidelines and protocols are made for effectively and efficiently handling patients with COVID-19 in the dental clinic and minimizing risk of nosocomial transmissions. Patients with respiratory infections (current or in the last 48 h) and those with travel histories to COVID-19-affected regions should be reported to the health department and should be rescheduled. The International Association of Paediatric Dentistry [13] has also made recommendations for parents to maintain optimal oral health of children and avoiding dental clinic visits: abstract: nan url: https://doi.org/10.1093/occmed/kqaa055 doi: 10.1093/occmed/kqaa055 id: cord-312388-pc89ybxw author: Singhania, Namrata title: Current Overview on Hypercoagulability in COVID-19 date: 2020-08-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought many unique pathologies, such as coagulopathy, prompting a desperate need for effective management. COVID-19-associated coagulopathy (CAC) can cause various thromboembolic complications, especially in critically ill patients. The pathogenesis is likely due to endothelial injury, immobilization, and an increase in circulating prothrombotic factors. Data on treatment are limited, although prophylactic anticoagulation is advised in all hospitalized patients. Herein, we have comprehensively reviewed the current literature available on CAC and highlight the pathogenesis, clinical features, and management of CAC. url: https://www.ncbi.nlm.nih.gov/pubmed/32748336/ doi: 10.1007/s40256-020-00431-z id: cord-351446-j4ambec5 author: Sinonquel, P. title: COVID‐19 and gastrointestinal endoscopy: what should be taken into account? date: 2020-04-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: On March 11(th) 2020 the World Health Organisation (WHO) declared COVID‐19 pandemic, leading to a subsequent impact on the entire world and health care system. Since the causing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) houses in the aerodigestive tract, activities in the gastrointestinal outpatient clinic and endoscopy unit should be limited to emergencies only. Health care professionals are faced with the need to perform endoscopic or endoluminal emergency procedures in patients with a confirmed positive or unknown COVID‐19 status. With this report we aim to provide recommendations and practical relevant information for gastroenterologists based on the limited amount of available data and local experience, to guarantee a high‐quality patient care and adequate infection prevention in the gastroenterology clinic. url: https://doi.org/10.1111/den.13706 doi: 10.1111/den.13706 id: cord-001617-ff3j7i7i author: Siqueira, André M title: Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India date: 2015-03-20 words: 7186.0 sentences: 306.0 pages: flesch: 38.0 cache: ./cache/cord-001617-ff3j7i7i.txt txt: ./txt/cord-001617-ff3j7i7i.txt summary: BACKGROUND: The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complications. We have used a common protocol in order to prospectively follow vivax malaria patients admitted to two distinct reference centers located in Brazil and India, aiming to comprehensively characterize and compare the clinical complications of P. The influence of these factors could already be observed by comparing the descriptions of clinical epidemiology of complications associated with this infection from different sites, showing that in areas of higher transmission intensities, children are the most frequently affected population [18, 19, 39, 40] , while in areas of moderate and low intensities, adults contribute more to the proportion of severe cases [7, 14, 41] . abstract: BACKGROUND: The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complications. Endemic areas exhibit wide variations regarding severe disease frequency. This study, conducted simultaneously in Brazil and India, constitutes, to our knowledge, the first multisite study focused on clinical characterization of P. vivax severe disease. METHODS: Patients admitted with P. vivax mono-infection at reference centers in Manaus (Amazon - Brazil) and Bikaner (Rajasthan - India), where P. vivax predominates, were submitted to standard thorough clinical and laboratory evaluations in order to characterize clinical manifestations and identify concurrent co-morbidities. RESULTS: In total, 778 patients (88.0% above 12 years old) were hospitalized at clinical discretion with PCR-confirmed P. vivax mono-infection (316 in Manaus and 462 in Bikaner), of which 197 (25.3%) presented at least one severity criterion as defined by the World Health Organization (2010). Hyperlactatemia, respiratory distress, hypoglycemia, and disseminated intravascular coagulation were more frequent in Manaus. Noteworthy, pregnancy status was associated as a risk factor for severe disease (OR = 2.03; 95% CI = 1.2-3.4; P = 0.007). The overall case fatality rate was 0.3/1,000 cases in Manaus and 6.1/1,000 cases in Bikaner, with all deaths occurring among patients fulfilling at least one severity criterion. Within this subgroup, case fatality rates increased respectively to 7.5% in Manaus and 4.4% in Bikaner. CONCLUSION: P. vivax-associated severity is not negligible, and although lethality observed for complicated cases was similar, the overall fatality rate was about 20-fold higher in India compared to Brazil, highlighting the variability observed in different settings. Our observations highlight that pregnant women and patients with co-morbidities need special attention when infected by this parasite due to higher risk of complications. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12916-015-0302-y) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404636/ doi: 10.1186/s12916-015-0302-y id: cord-334715-902pfxyz author: Sirico, Domenico title: Cardiac imaging in congenital heart disease during the coronavirus disease-2019 pandemic: recommendations from the Working Group on Congenital Heart Disease of the Italian Society of Cardiology date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The recent outbreak of 2019 severe acute respiratory syndrome coronavirus-2 is having major repercussions on healthcare services provision in Italy and worldwide. Data suggest the virus has a strong impact on the cardiovascular system, and cardiac imaging will play an important role in patients affected by coronavirus disease-2019. Although paediatric patients are mildly affected, they represent a clear accelerator in spreading the virus, and healthcare workers are at higher risk of infection. The aim of this position paper is to provide clinical recommendation regarding the execution of imaging investigations for the cardiac diagnostic work-up of paediatric patients with suspected or confirmed infection. url: https://doi.org/10.2459/jcm.0000000000000990 doi: 10.2459/jcm.0000000000000990 id: cord-255746-ir73lpi8 author: Sirimaturos, Michael title: Clinical Outcomes Following Tocilizumab Administration in Mechanically Ventilated Coronavirus Disease 2019 Patients date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Effective treatments for the critically ill patient with novel coronavirus disease 2019 are desperately needed. Given the role of cytokine release syndrome in the pathogenesis of coronavirus disease 2019-associated respiratory distress, therapies aimed at mitigating cytokine release, such as the interleukin-6 receptor-inhibiting monoclonal antibody tocilizumab, represent potential treatment strategies. Therefore, we examined the outcomes of critically ill coronavirus disease 2019 patients treated with tocilizumab and factors associated with clinical improvement. DESIGN: A retrospective cohort analysis of 21-day outcomes for consecutive mechanically ventilated patients treated with tocilizumab from March 24, 2020, to May 4, 2020. SETTING: Nine ICUs at six hospitals within a hospital system in Houston, Texas, United States. PATIENTS: The first 62 coronavirus disease 2019 patients on invasive mechanical ventilation who were treated with tocilizumab, which was considered for all patients with severe disease. INTERVENTIONS: Tocilizumab was administered either at a weight-based dose of 4–8 mg/kg or at a flat dose of 400 mg, with repeat administration in some patients at the physician’s discretion. MEASUREMENTS AND MAIN RESULTS: The primary outcomes were mortality and clinical improvement, defined as extubation. By day 21 post-tocilizumab, clinical improvement occurred in 36 patients (58%) and 13 patients (21%) died. In both univariable and multivariable analyses, age less than 60 years was associated with clinical improvement. Transient transaminitis was the most common adverse reaction, occurring in 25 patients (40%). CONCLUSIONS: Based on clinical outcomes and mortality rates seen in previous reports of mechanically ventilated patients, tocilizumab, as part of the management strategy for severe coronavirus disease 2019, represents a promising option. These findings support the need for evaluation of tocilizumab in a randomized controlled trial. url: https://www.ncbi.nlm.nih.gov/pubmed/33063035/ doi: 10.1097/cce.0000000000000232 id: cord-339355-zkkj8a83 author: Siripanthong, Bhurint title: Coronavirus disease 2019 is delaying the diagnosis and management of chest pain, acute coronary syndromes, myocarditis and heart failure date: 2020-07-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.2217/fca-2020-0088 doi: 10.2217/fca-2020-0088 id: cord-329727-h47q76y8 author: Sisó-Almirall, Antoni title: Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona date: 2020-08-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: In addition to the lack of COVID-19 diagnostic tests for the whole Spanish population, the current strategy is to identify the disease early to limit contagion in the community. AIM: To determine clinical factors of a poor prognosis in patients with COVID-19 infection. DESIGN AND SETTING: Descriptive, observational, retrospective study in three primary healthcare centres with an assigned population of 100,000. METHOD: Examination of the medical records of patients with COVID-19 infections confirmed by polymerase chain reaction. Logistic multivariate regression models adjusted for age and sex were constructed to analyse independent predictive factors associated with death, ICU admission and hospitalization. RESULTS: We included 322 patients (mean age 56.7 years, 50% female, 115 (35.7%) aged ≥ 65 years): 123 (38.2) were health workers (doctors, nurses, auxiliaries). Predictors of ICU admission or death were greater age (OR = 1.05; 95%CI = 1.03 to 1.07), male sex (OR = 2.94; 95%CI = 1.55 to 5.82), autoimmune disease (OR = 2.82; 95%CI = 1.00 to 7.84), bilateral pulmonary infiltrates (OR = 2.86; 95%CI = 1.41 to 6.13), elevated lactate-dehydrogenase (OR = 2.85; 95%CI = 1.28 to 6.90), elevated D-dimer (OR = 2.85; 95%CI = 1.22 to 6.98) and elevated C-reactive protein (OR = 2.38; 95%CI = 1.22 to 4.68). Myalgia or arthralgia (OR = 0.31; 95%CI = 0.12 to 0.70) was protective factor against ICU admission and death. Predictors of hospitalization were chills (OR = 5.66; 95%CI = 1.68 to 23.49), fever (OR = 3.33; 95%CI = 1.89 to 5.96), dyspnoea (OR = 2.92; 95%CI = 1.62 to 5.42), depression (OR = 6.06; 95%CI = 1.54 to 40.42), lymphopenia (OR = 3.48; 95%CI = 1.67 to 7.40) and elevated C-reactive protein (OR = 3.27; 95%CI = 1.59 to 7.18). Anosmia (OR = 0.42; 95%CI = 0.19 to 0.90) was the only significant protective factor for hospitalization after adjusting for age and sex. CONCLUSION: Determining the clinical, biological and radiological characteristics of patients with suspected COVID-19 infection will be key to early treatment and isolation and the tracing of contacts. url: https://www.ncbi.nlm.nih.gov/pubmed/32822413/ doi: 10.1371/journal.pone.0237960 id: cord-263628-ac9gld5l author: Sivapalan, Pradeesh title: Proactive prophylaxis with azithromycin and hydroxychloroquine in hospitalized patients with COVID-19 (ProPAC-COVID): a statistical analysis plan date: 2020-10-20 words: 3487.0 sentences: 205.0 pages: flesch: 52.0 cache: ./cache/cord-263628-ac9gld5l.txt txt: ./txt/cord-263628-ac9gld5l.txt summary: The ProPac-COVID trial evaluates whether combination therapy with macrolide azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy, and pre-emptive treatment of supra-infections can shorten hospitalization duration and reduce the risk of non-invasive ventilation, treatment in the intensive care unit, and death in patients with acute hospital admission and a positive test for 2019-nCoV and symptoms of COVID-19 disease. The objective of this randomized, placebo-controlled, double-blinded multi-center trial is to investigate whether 15-day treatment with azithromycin and hydroxychloroquine added to standard of care can shorten hospitalization and reduce the risk of non-invasive ventilation, admittance to ICU, and death. The interim analysis will focus on reporting the following: selected baseline data (those readily available from the baseline data list below), primary outcome (in an O'' Brien-Fleming Plot), and all-cause mortality at 30 days (chi-square or Fisher''s exact test, whichever appropriate). abstract: BACKGROUND: There is an urgent need for treatments that can shorten hospitalization and lower the risk of secondary infection and death in patients with corona disease. The ProPac-COVID trial evaluates whether combination therapy with macrolide azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy, and pre-emptive treatment of supra-infections can shorten hospitalization duration and reduce the risk of non-invasive ventilation, treatment in the intensive care unit, and death in patients with acute hospital admission and a positive test for 2019-nCoV and symptoms of COVID-19 disease. METHODS: The ProPAC-COVID is a multi-center, randomized, placebo-controlled, double-blinded clinical trial. The primary outcome is number of days spent alive and out of hospital within 14 days from randomization. Randomization will be in blocks of unknown size, and the final allocation will be stratified for age, site of recruitment, and whether the patient has any chronic lung diseases. Data is analyzed using intention-to-treat (ITT) principles, and main analyses will also be subject to modified ITT analysis and per protocol analysis. DISCUSSION: This paper describes the detailed statistical analysis plan for the evaluation of primary and secondary endpoints of the ProPAC-COVID study. Enrolment of patients to the ProPAC-COVID study is still ongoing. The purpose of this paper is to provide primary publication of study results to prevent selective reporting of outcomes, data-driven analysis, and to increase transparency. TRIAL REGISTRATION: ClinicalTrials.gov NCT04322396. Registered on 26 March 2020. url: https://doi.org/10.1186/s13063-020-04795-0 doi: 10.1186/s13063-020-04795-0 id: cord-331487-jh34klbg author: Sivapalan, Pradeesh title: Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and pre-emptive treatment of supra-infections can shorten hospitalisation duration for patients with COVID-19 (measured as "days alive and out of hospital" as the primary outcome), reduce the risk of non- invasive ventilation, treatment in the intensive care unit and death. TRIAL DESIGN: This is a multi-centre, randomised, Placebo-controlled, 2-arm ratio 1:1, parallel group double-blind study. PARTICIPANTS: 226 participants are recruited at the trial sites/hospitals, where the study will take place in Denmark: Aalborg, Bispebjerg, Gentofte, Herlev, Hillerød, Hvidovre, Odense and Slagelse hospitals. Inclusion criteria: • Patient admitted to Danish emergency departments, respiratory medicine departments or internal medicine departments • Age≥ 18 years • Hospitalized ≤48 hours • Positive COVID-19 test / diagnosis during the hospitalization (confirmed). • Men or non-fertile women. Fertile women* must not be pregnant, i.e. negative pregnancy test must be available at inclusion • Informed consent signed by the patient *Defined as after menarche and until postmenopausal (no menstruation for 12 months) Exclusion criteria: • At the time of recruitment, the patient uses >5 LO2/min (equivalent to 40% FiO2 if measured) • Known intolerance/allergy to azithromycin or hydroxychloroquine or hypersensitivity to quinine or 4-aminoquinoline derivatives • Neurogenic hearing loss • Psoriasis • Retinopathy • Maculopathy • Visual field changes • Breastfeeding • Severe liver diseases other than amoebiasis (INR> 1.5 spontaneously) • Severe gastrointestinal, neurological and hematological disorders (investigator-assessed) • eGFR <45 ml/min/1.73 m2 • Clinically significant cardiac conduction disorders/arrhythmias or prolonged QTc interval (QTc (f) of> 480/470 ms). • Myasthenia gravis • Treatment with digoxin* • Glucose-6-phosphate dehydrogenase deficiency • Porphyria • Hypoglycaemia (Blood glucose at any time since hospitalization of <3.0 mmol/L) • Severe mental illness which significantly impedes cooperation • Severe linguistic problems that significantly hinder cooperation • Treatment with ergot alkaloids *The patient must not be treated with digoxin for the duration of the intervention. For atrial fibrillation/flutter, select according to the Cardiovascular National Treatment Guide (NBV): Calcium antagonist, Beta blocker, direct current (DC) conversion or amiodarone. In case of urgent need for digoxin treatment (contraindication for the aforementioned equal alternatives), the test drug should be paused, and ECG should be taken daily. INTERVENTION AND COMPARATOR: Control group: The control group will receive the standard treatment + placebo for both types of intervention medication at all times. If part or all the intervention therapy being investigated becomes standard treatment during the study, this may also be offered to the control group. Intervention group: The patients in the intervention group will also receive standard care. Immediately after randomisation to the intervention group, the patient will begin treatment with: Azithromycin: Day 1-3: 500 mg x 1 Day 4-15: 250 mg x 1 If the patient is unable to take the medication orally by themselves, the medication will, if possible, be administered by either stomach-feeding tube, or alternatively, temporary be changed to clarithromycin 500 mg x 2 (this only in agreement with either study coordinator Pradeesh Sivapalan or principal investigator Jens-Ulrik Stæhr Jensen). This will also be done in the control group if necessary. The patient will switch back to azithromycin when possible. Hydroxychloroquine: Furthermore, the patient will be treated with hydroxychloroquine as follows: Day 1-15: 200 mg x 2 MAIN OUTCOMES: • Number of days alive and discharged from hospital within 14 days (summarises both whether the patient is alive and discharged from hospital) ("Days alive and out of hospital") RANDOMISATION: The sponsor (Chronic Obstructive Pulmonary Disease Trial Network, COP:TRIN) generates a randomisation sequence. Randomisation will be in blocks of unknown size and the final allocation will be via an encrypted website (REDCap). There will be stratification for age (>70 years vs. <=70 years), site of recruitment and whether the patient has any of the following chronic lung diseases: COPD, asthma, bronchiectasis, interstitial lung disease (Yes vs. No). BLINDING (MASKING): Participants and study personnel will both be blinded, i.e. neither will know which group the participant is allocated to. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): This study requires 226 patients randomised 1:1 with 113 in each group. TRIAL STATUS: Protocol version 1.8, from April 16, 2020. Recruitment is ongoing (first patient recruited April 6, 2020; final patient expected to be recruited October 31, 2020). TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04322396 (registered March 26, 2020) FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). url: https://www.ncbi.nlm.nih.gov/pubmed/32522282/ doi: 10.1186/s13063-020-04409-9 id: cord-271603-zy4l9vtf author: Skali, Hicham title: Guidance and Best Practices for Reestablishment of Non-Emergent Care in Nuclear Cardiology Laboratories During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Information Statement from ASNC, IAEA, and SNMMI date: 2020-10-17 words: 3726.0 sentences: 206.0 pages: flesch: 42.0 cache: ./cache/cord-271603-zy4l9vtf.txt txt: ./txt/cord-271603-zy4l9vtf.txt summary: title: Guidance and Best Practices for Reestablishment of Non-Emergent Care in Nuclear Cardiology Laboratories During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Information Statement from ASNC, IAEA, and SNMMI • For SPECT myocardial perfusion imaging studies in inpatients who are not eligible for stress only testing, consider performing the rest injection in the patient''s inpatient room, to avoid completely or minimize waiting time in the laboratory. The nuclear cardiology laboratory''s protocols and patient scheduling templates will need to be closely monitored and refined multiple times over the coming months as the COVID-19 pandemic slowly recedes, with potential for local or widespread waves of new COVID-19 infections. • Providers and institutions should monitor local data and follow national, state, and department of public health recommendations for possible second COVID-19 waves that may require decreasing nuclear cardiology laboratory activities and enhanced protective measures. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32709732/ doi: 10.2967/jnumed.120.251355 id: cord-347280-jpwf55l6 author: Skevaki, Chrysanthi title: Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus date: 2020-06-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A subgroup of COVID-19 patients develop very severe disease with requirement for ICU treatment, ventilation, and ECMO therapy. Laboratory tests indicate that the immune and clotting system show marked alterations with hyper-activation, hyper-inflammation, cytokine storm development. Furthermore, organ-specific biomarkers demonstrate the involvement of cardiac muscle, kidney, and liver dysfunction in many patients. In this article the use of laboratory biomarkers is discussed with regard to their use for diagnosis, disease progression, and risk assessment. url: https://doi.org/10.1016/j.jinf.2020.06.039 doi: 10.1016/j.jinf.2020.06.039 id: cord-354204-23xkug85 author: Smargiassi, Andrea title: Lung ultrasonography for early management of patients with respiratory symptoms during COVID-19 pandemic date: 2020-07-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 pandemic is representing a serious challenge to worldwide public health. Lung Ultrasonography (LUS) has been signaled as a potential useful tool in this pandemic contest either to intercept viral pneumonia or to foster alternative paths. LUS could be useful in determining early lung involvement suggestive or not of COVID-19 pneumonia and potentially plays a role in managing decisions for hospitalization in isolation or admission in general ward. In order to face pandemic, in a period in which a large number of emergency room accesses with suspicious symptoms are expected, physicians need a standardized ultrasonographic approach, fast educational processes in order to be able to recognize both suggestive and not suggestive echographic signs and shared algorithms for LUS role in early management of patients. url: https://doi.org/10.1007/s40477-020-00501-7 doi: 10.1007/s40477-020-00501-7 id: cord-257467-b8o5ghvi author: Smith, Barbara A. title: Anesthesia as a Risk for Health Care Acquired Infections date: 2010-12-31 words: 4506.0 sentences: 276.0 pages: flesch: 42.0 cache: ./cache/cord-257467-b8o5ghvi.txt txt: ./txt/cord-257467-b8o5ghvi.txt summary: This article further discusses the risks for HAIs apparent in intravascular cannulation, endotracheal intubation, and the development of surgical site infections, and examines occupational measures to prevent infections in the health care worker. Although endotracheal intubation during surgery is generally a controlled safe procedure, this artificial airway predisposes the body to exposure to respiratory pathogens whether from the health care provider, the environment, or equipment. 12 A recent practice advisory prepared by the American Society of Anesthesiologists (ASA) concurs with the implementation of aseptic technique when handling neuraxial needles and catheters, and states it should include "hand washing, wearing of sterile gloves, wearing of caps, wearing of masks covering both the mouth and nose, use of individual packets of skin preparation, and sterile draping of the patient." The same advisory does not make a specific recommendation regarding the type of skin antisepsis to use. abstract: Anesthesia is delivered in a variety of modalities including general, regional, or local. Patients are most vulnerable when receiving anesthesia, as they must depend on the anesthesia team to provide this care without untoward effects. It is expected that patients will be protected from health care acquired infections (HAIs) by appropriate use of infection prevention measures. In addition, the anesthesia team may be at risk of HAIs because of their intimate contact with the patient's blood and respiratory system. Adequate adherence to infection prevention methods should reduce the risk of occupation exposure and infection to the anesthesia team members. Health care associated infections involving anesthesia have been transmitted from health care worker to patient, patient to patient, and patient to the anesthesia provider. This article further discusses the risks for HAIs apparent in intravascular cannulation, endotracheal intubation, and the development of surgical site infections, and examines occupational measures to prevent infections in the health care worker. Regardless of the health care setting or the level of provider, the standard of care for infection prevention and managerial oversight of this care should remain the same. url: https://api.elsevier.com/content/article/pii/S1556793110000653 doi: 10.1016/j.cpen.2010.07.005 id: cord-346345-jc9bq0zu author: Smith, Colin M title: COVID-19-associated brief psychotic disorder date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A 36-year-old previously healthy woman with no personal or family history of mental illness presented with new-onset psychosis after a diagnosis of symptomatic COVID-19. Her psychotic symptoms initially improved with antipsychotics and benzodiazepines and further improved with resolution of COVID-19 symptoms. This is the first case of COVID-19-associated psychosis in a patient with no personal or family history of a severe mood or psychotic disorder presenting with symptomatic COVID-19, highlighting the need for vigilant monitoring of neuropsychiatric symptoms in these individuals. url: https://www.ncbi.nlm.nih.gov/pubmed/32784244/ doi: 10.1136/bcr-2020-236940 id: cord-029112-u507i0t0 author: Smith, Keisha title: A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date: 2020-07-13 words: 20880.0 sentences: 1243.0 pages: flesch: 46.0 cache: ./cache/cord-029112-u507i0t0.txt txt: ./txt/cord-029112-u507i0t0.txt summary: Study ALXN1210-COV-305 is a multicenter Phase 3, open-label, randomized, controlled study designed to evaluate the safety and efficacy of intravenous (IV) ravulizumab + best supportive care (BSC), compared with BSC alone in patients with a confirmed diagnosis of SARS-CoV-2 infection, and a clinical presentation consistent with COVID-19 severe pneumonia, acute lung injury, or ARDS. abstract: OBJECTIVES: Primary Objective • To evaluate the effect of ravulizumab, a long-acting complement (C5) inhibitor plus best supportive care (BSC) compared with BSC alone on the survival of patients with COVID-19. Secondary Objectives • Number of days free of mechanical ventilation at Day 29 • Duration of intensive care unit stay at Day 29 • Change from baseline in Sequential Organ Failure Assessment (SOFA) score at Day 29 • Change from baseline in peripheral capillary oxygen saturation/ fraction of inspired oxygen (SpO2 /FiO2) at Day 29 • Duration of hospitalization at Day 29 • Survival (based on all-cause mortality) at Day 60 and Day 90 Safety • Incidence of treatment-emergent adverse events and treatment-emergent serious adverse events. PK/PD/Immunogenicity • Change in serum ravulizumab concentrations over time • Change in serum free and total C5 concentrations over time • Incidence and titer of anti-ALXN1210 antibodies Biomarkers • Change in absolute level of soluble biomarkers in blood associated with complement activation, inflammatory processes, and hypercoagulable states over time Exploratory • Incidence of progression to renal failure requiring dialysis at Day 29 • Time to clinical improvement (based on a modified 6-point ordinal scale) over 29 days • SF-12 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores at Day 29 (or discharge), Day 60, and Day 90 • EuroQol 5-dimension 5-level (EQ-5D-5L) scores at Day 29 (or discharge), Day 60, and Day 90 TRIAL DESIGN: This is a multicenter Phase 3, open-label, randomized, controlled, study. The study is being conducted in acute care hospital settings in the United States, United Kingdom, Spain, France, Germany, and Japan. PARTICIPANTS: Male or female patients at least 18 years of age, weighing ≥ 40 kg, admitted to a designated hospital facility for treatment will be screened for eligibility in this study. Key Inclusion criteria • Confirmed diagnosis of SARS-CoV-2 infection (eg, via polymerase chain reaction [PCR] and/or antibody test) presenting as severe COVID-19 requiring hospitalization • Severe pneumonia, acute lung injury, or ARDS confirmed by computed tomography (CT) or X-ray at Screening or within the 3 days prior to Screening, as part of the patient’s routine clinical care • Respiratory distress requiring mechanical ventilation, which can be either invasive (requiring endotracheal intubation) or non-invasive (with continuous positive airway pressure [CPAP] or bilevel positive airway pressure [BiPAP]) Key Exclusion criteria • Patient is not expected to survive for more than 24 hours • Patient is on invasive mechanical ventilation with intubation for more than 48 hours prior to Screening • Severe pre-existing cardiac disease (ie, NYHA Class 3 or Class 4, acute coronary syndrome, or persistent ventricular tachyarrhythmias) • Patient has an unresolved Neisseria meningitidis infection Excluded medications and therapies • Current treatment with a complement inhibitor • Intravenous immunoglobulin (IVIg) within 4 weeks prior to randomization on Day 1 Excluded prior/concurrent clinical study experience • Treatment with investigational therapy in a clinical study within 30 days before randomization, or within 5 half-lives of that investigational therapy, whichever is greater • Exceptions a. Investigational therapies will be allowed if received as part of best supportive care through an expanded access protocol or emergency approval for the treatment of COVID-19. b. Investigational antiviral therapies (such as remdesivir) will be allowed even if received as part of a clinical study. INTERVENTION AND COMPARATOR: The study consists of a Screening Period of up to 3 days, a Primary Evaluation Period of 4 weeks, a final assessment at Day 29, and a Follow-up Period of 8 weeks. For patients randomized to ravulizumab plus BSC, a weight-based dose of ravulizumab (≥40 to < 60 kg/2400 mg, 60 to < 100 kg/2700 mg, ≥ 100 kg/3000 mg) will be administered on Day 1. On Day 5 and Day 10, additional doses of 600 mg (≥40 to <60 kg) or 900 mg (>60 kg) ravulizumab will be administered and on Day 15 patients will receive 900 mg ravulizumab. There is no active or placebo comparator in this open-label clinical trial. The total duration of each patient’s participation is anticipated to be approximately 3 months. MAIN OUTCOMES: The primary efficacy outcome of this study is survival (based on all-cause mortality) at Day 29. RANDOMISATION: Patients will be randomized in a 2:1 ratio (ravulizumab plus BSC:BSC alone). Randomization will be stratified by intubated or not intubated on Day 1. Computer-generated randomization lists will be prepared by a third party under the direction of the sponsor. Investigators, or designees, will enrol patients and then obtain randomization codes using an interactive voice/web response system. The block size will be kept concealed so that investigators cannot select patients for a particular treatment assignment. Blinding (masking): This is an open-label study. Numbers to be randomised (sample size): Approximately 270 patients will be randomly assigned in a 2:1 ratio to ravulizumab plus BSC (n=180) or BSC alone (n=90). TRIAL STATUS: Protocol Number: ALXN1210-COV-305 Original Protocol: 09 Apr 2020 Protocol Amendment 1 (Global): 13 Apr 2020 Protocol Amendment 2 (Global): 17 Apr 2020 Protocol Amendment 3 (Global): 09 Jun 2020 Recruitment is currently ongoing. Recruitment was initiated on 11 May 2020. We expect recruitment to be completed by 30 Nov 2020. TRIAL REGISTRATION: Clinicaltrials.gov: Protocol Registry Number: NCT04369469; First posted; 30 Apr 2020 EU Clinical Trials Register: EudraCT Number: https://www.clinicaltrialsregister.eu/ctr-search/search?query=ALXN1210-COV-305, Start date: 07 May 2020 FULL PROTOCOL: The full redacted protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355517/ doi: 10.1186/s13063-020-04548-z id: cord-328220-toeq4xq0 author: Smith, Kelly title: Practical Considerations in Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID-19 date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: There are increasing reports in the literature of high rates of coagulopathy and venous thromboembolism (VTE) among hospitalized patients with coronavirus disease 2019 (COVID-19). Understanding of these abnormalities is continually evolving, but these conditions may pose a risk to COVID-19 patients beyond the risk typically seen in critically ill patients. SUMMARY: There are currently no widely accepted evidence-based guidelines regarding specifics related to treatment and prevention of COVID-19–related coagulopathies. Areas of management requiring clinical equipoise include agent selection and dosing, continuation vs interruption of home oral anticoagulant therapy during hospital admission, and postdischarge VTE prophylaxis. Clinicians may wish to consider use of a stratified, 3-tiered approach of low-intensity anticoagulation, intermediate-intensity anticoagulation, and therapeutic-dose anticoagulation. Patients can be categorized by tier depending on their risk factors for VTE, acuity of illness, and laboratory values such as D-dimer level. CONCLUSION: Practical guidance on anticoagulation considerations and dosing suggestions are provided to assist clinicians faced with challenging anticoagulation-related situations in caring for hospitalized COVID patients until formal evidence-based guidelines become available. url: https://doi.org/10.1093/ajhp/zxaa245 doi: 10.1093/ajhp/zxaa245 id: cord-017862-9fkjjmvf author: Smith, Roger P. title: Respiratory Disorders date: 2007 words: 6045.0 sentences: 342.0 pages: flesch: 51.0 cache: ./cache/cord-017862-9fkjjmvf.txt txt: ./txt/cord-017862-9fkjjmvf.txt summary: Only 12-25% of all "sore throats" seen by physicians have a true pharyngitis-most are simple viral upper respiratory infections such as the common cold. infl uenzae, Staphylococcus aureus, Legionella pneumophila, and Allergens such as pollens, molds, animal dander, dust mites, and cockroaches Irritants such as strong odors and sprays, chemicals, air pollutants, tobacco smoke, and cold air Viral or sinus infections including colds, pneumonia, and sinusitis Exercise, especially in cold, dry air Gastroesophageal refl ux disease (GERD), a condition in which stomach acid fl ows back up the esophagus Medication and foods Emotional anxiety others) is the most common source of infection for most patients. Infl uenza, rubeola and rubella, Mycoplasma pneumonia, group A β-hemolytic streptococcal infections, and allergic rhinitis may all be confused with the common cold and should be considered when appropriate. When a common cold has lasted for 7-10 days and is no better or worse, acute bacterial sinusitis may have developed and additional medical care may be required. abstract: Like it or not, patients with respiratory complaints are a part of our practice. The common cold is often referred to as the most frequent illness occurring in humans: over 40% of Americans suffer from a “cold” each year, accounting for more lost productivity than any other illness. Pharyngitis affects almost 30 million patients annually, with over 10% of all school-aged children seeking medical care each year. Seventeen million patients a year are diagnosed with asthma, with more females than males among adult-onset patients. Whether it is the reason for our patient’s visit or an incidental complaint, we are involved with the diagnosis and management of these problems. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122541/ doi: 10.1007/978-0-387-32328-2_19 id: cord-264952-0t0t4x0y author: Smith, Sean R title: Proposed Workflow for Rehabilitation in a Field Hospital Setting During the COVID‐19 Pandemic date: 2020-05-15 words: 2973.0 sentences: 196.0 pages: flesch: 51.0 cache: ./cache/cord-264952-0t0t4x0y.txt txt: ./txt/cord-264952-0t0t4x0y.txt summary: [1, 5] Without rehabilitation, numerous patients may require extra days in the field hospital setting, taking up needed bed space and increasing use of PPE and healthcare personnel. Patients with more impaired function and who have clear barriers to discharge modifiable with rehabilitation intervention -including not being able to navigate steps to enter their house and requiring assistance for transfers -will be triaged to receive as much physical and occupational therapy as resources allow, with physiatry involvement as indicated to help with discharge planning and symptom management. When a field hospital has no dedicated space for rehabilitation, patients should receive appropriate ongoing therapies and be provided with information regarding bed exercises, exercises with family, and home exercise programs that appropriately address the symptoms of the disease. abstract: The novel Coronavirus Disease 2019 (COVID‐19) pandemic has challenged healthcare facilities throughout the world. In many regions, the need for acute inpatient healthcare services has exceeded the capacity of hospital systems, and field hospitals are being utilized as one part of the response strategy. Given the urgency and novelty of this pandemic, healthcare systems are attempting to rapidly execute plans for field hospitals, and rehabilitative care in this environment merits particular consideration given the potential impacts of mobilization and rehabilitative therapies on morbidity, mortality, duration of ventilation, and lengths of ICU/hospital stay. In order to address this need, a model for rehabilitation in field hospitals is presented here. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/pmrj.12405 doi: 10.1002/pmrj.12405 id: cord-007798-9ht7cqhu author: Smith, Silas W. title: Drugs and pharmaceuticals: management of intoxication and antidotes date: 2010-02-25 words: 22555.0 sentences: 1371.0 pages: flesch: 34.0 cache: ./cache/cord-007798-9ht7cqhu.txt txt: ./txt/cord-007798-9ht7cqhu.txt summary: In the context of analgesic, anti-inflammatory, anticholinergic, anticonvulsant, antihyperglycemic, antimicrobial, antineoplastic, cardiovascular, opioid, or sedative-hypnotic agents overdose, N-acetylcysteine, physostigmine, l-carnitine, dextrose, octreotide, pyridoxine, dexrazoxane, leucovorin, glucarpidase, atropine, calcium, digoxin-specific antibody fragments, glucagon, high-dose insulin euglycemia therapy, lipid emulsion, magnesium, sodium bicarbonate, naloxone, and flumazenil are specifically reviewed. As might be anticipated from the fact that supportive care suffices for the majority of poisoned patients, a typical study of routine administration of charcoal following oral overdose of primarily benzodiazepines, acetaminophen, and selective serotonin reuptake inhibitors could not demonstrate benefit [16, 17, 23] . Patient characteristics suggesting extracorporeal therapy include signs or symptoms of significant end organ toxicity; impaired elimination secondary to baseline comorbidities or critical illness-induced hypoperfusion; inability to tolerate or refractory to antidotal strategies (such as bicarbonate or saline); inadequate response to supportive care measures; concurrent electrolyte derangements (e.g., metformin-associated lactic acidosis); or serum drug concentrations historically associated with severe outcome [127] . abstract: The treatment of patients poisoned with drugs and pharmaceuticals can be quite challenging. Diverse exposure circumstances, varied clinical presentations, unique patient-specific factors, and inconsistent diagnostic and therapeutic infrastructure support, coupled with relatively few definitive antidotes, may complicate evaluation and management. The historical approach to poisoned patients (patient arousal, toxin elimination, and toxin identification) has given way to rigorous attention to the fundamental aspects of basic life suppport — airway management, oxygenation and ventilation, circulatory competence, thermoregulation, and substrate availability. Selected patients may benefit from methods to alter toxin pharmacokinetics to minimize systemic, target organ, or tissue compartment exposure (either by decreasing absorption or increasing elimination). These may include syrup of ipecac, orogastric lavage, activated single- or multi-dose charcoal, whole bowel irrigation, endoscopy and surgery, urinary alkalinization, saline diuresis, or extracorporeal methods (hemodialysis, charcoal hemoperfusion, continuous venovenous hemofiltration, and exchange transfusion). Pharmaceutical adjuncts and antidotes may be useful in toxicant-induced hyperthermias. In the context of analgesic, anti-inflammatory, anticholinergic, anticonvulsant, antihyperglycemic, antimicrobial, antineoplastic, cardiovascular, opioid, or sedative-hypnotic agents overdose, N-acetylcysteine, physostigmine, l-carnitine, dextrose, octreotide, pyridoxine, dexrazoxane, leucovorin, glucarpidase, atropine, calcium, digoxin-specific antibody fragments, glucagon, high-dose insulin euglycemia therapy, lipid emulsion, magnesium, sodium bicarbonate, naloxone, and flumazenil are specifically reviewed. In summary, patients generally benefit from aggressive support of vital functions, careful history and physical examination, specific laboratory analyses, a thoughtful consideration of the risks and benefits of decontamination and enhanced elimination, and the use of specific antidotes where warranted. Data supporting antidotes effectiveness vary considerably. Clinicians are encouraged to utilize consultation with regional poison centers or those with toxicology training to assist with diagnosis, management, and administration of antidotes, particularly in unfamiliar cases. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123602/ doi: 10.1007/978-3-7643-8338-1_12 id: cord-284188-ujdla954 author: Smith, Silas W. title: Virtual Urgent Care Quality and Safety in the Time of Coronavirus date: 2020-10-16 words: 5905.0 sentences: 353.0 pages: flesch: 50.0 cache: ./cache/cord-284188-ujdla954.txt txt: ./txt/cord-284188-ujdla954.txt summary: To assess patient and provider data, systems effectiveness, and ability to provide care with and without admission to the ED, 17, 18 we identified the following variables from the cohort records: provider type, patient age, self-assigned gender, visit date, self-assigned race/ethnicity, 19 comorbidities, previous primary care visits (as an indirect marker of regular access to care), VUC return visits, ED referrals and spontaneous ED visits, ED and dispositions, intubations, and deaths following VUC visits. We evaluated and manually reviewed all patients identified for follow-up to assess outcomes including ED referral during follow-up screening call, hospital admission and course, presence or absence of ED referral on index VUC visit, mortality, and interval metrics. 17 While no direct comparators existed during the pandemic, when decision thresholds to present to the ED were multifactorial, to provide context for departments managing patients as outpatients, we evaluated similar outcomes of patients presenting for ED care who were discharged (not admitted) during the same time period. abstract: INTRODUCTION: Telemedicine use rapidly increased during the coronavirus disease 2019 pandemic. We assessed quality aspects of rapid expansion of a virtual urgent care (VUC) telehealth system and the effects of a secondary telephonic screening initiative during the pandemic. METHODS: We performed a retrospective cohort analysis in a single hospital network of VUC patients from March 1, 2020 through April 20, 2020. We abstracted demographic data, comorbidities, VUC return visits, emergency department (ED) referrals, and ED visits, dispositions, intubations, and deaths. We also reviewed incomplete visits. For comparison, we evaluated outcomes of non-admission dispositions from the ED: return visits with and without admission and deaths. We separately analyzed the effects of enhanced callback system targeting higher risk patients with COVID-like illness during the last two weeks of the study period. RESULTS: A total of 18,278 unique adult patients completed 22,413 VUC visits. Separately, 718 patient-scheduled visits were incomplete; the majority were no-shows. 50.9% of all patients and 74.0% of patients aged 60 years or older had comorbidities. Of VUC visits, 6.8% had a subsequent VUC encounter within 72 hours; 1.8% had a subsequent ED visit. Of patients with enhanced follow-up, 4.3% were referred for ED evaluation. Mortality was 0.20% overall; 0.21% initially and 0.16% with enhanced follow-up (p = 0.59). Males and black patients were significantly overrepresented in decedents. CONCLUSION: Appropriately deployed VUC services can provide a pragmatic strategy to care for large numbers of patients. Ongoing surveillance of operational, technical, and clinical factors is critical for patient quality and safety with this modality. url: https://api.elsevier.com/content/article/pii/S1553725020302713 doi: 10.1016/j.jcjq.2020.10.001 id: cord-263066-umvojci8 author: Smondack, P. title: Kinésithérapie et COVID-19 : de la réanimation à la réhabilitation à domicile. Synthèse des recommandations internationales date: 2020-10-13 words: 5669.0 sentences: 533.0 pages: flesch: 63.0 cache: ./cache/cord-263066-umvojci8.txt txt: ./txt/cord-263066-umvojci8.txt summary: Ainsi, l''indication doit être discutée en staff pluridisciplinaire et le MK ne doit pas entrer dans la chambre du patient uniquement pour évaluer les besoins en kinésithérapie, mais uniquement quand ces besoins ont été évalués au préalable et que la nécessité d''actes kinésithérapiques a été décidée [14, 18] . Les patients présentant des formes modérées nécessitant une hospitalisation sans passage en réanimation sont également pris en charge dans ces services. Ces mesures d''hygiène, notamment le port du masque chirurgical, le lavage des mains et la distanciation sociale doivent s''appliquer dans la mesure du possible pour tous les patients, même non infectés par le SARS-CoV-2 [4, 10, 15, 20, 34] . Les MK ont donc un rôle essentiel dans la prise en charge des patients atteints de COVID-19 et ce, sur du long terme, plusieurs semaines après la maladie. abstract: INTRODUCTION: The new coronavirus disease 2019 (COVID-19) is responsible for a global pandemic and many deaths. This context requires an adaptation of health systems as well as the role of each healthcare professional, including physiotherapists. STATE OF THE ART: In order to optimize the management of people with COVID-19, many savant societies published guidelines about physiotherapy interventions within the crisis but none offered a global overview from the intensive care unit to home care. Therefore, the aim of this review is to offer an overview of recommended physiotherapy interventions in order to facilitate the management of these patients, whatever the stage of the disease. PERSPECTIVES: Owing to the emergent character of the COVID-19, actual guidelines will have to be adjusted according to the evolution of the pandemic and the resources of the hospital and liberal sectors, in particular for the long-term follow-up of these patients. Current and future research will aim to assess the effectiveness of physiotherapy interventions for people with COVID-19. CONCLUSION: The emergence of COVID-19 required a very rapid adaptation of the health system. The role of physiotherapists is justified at every stage of patients care in order to limit the functional consequences of the disease. url: https://doi.org/10.1016/j.rmr.2020.09.001 doi: 10.1016/j.rmr.2020.09.001 id: cord-289533-hip9qtu5 author: Smulever, Anabella title: Thyroid cancer in the Era of COVID-19 date: 2020-08-04 words: 2822.0 sentences: 130.0 pages: flesch: 41.0 cache: ./cache/cord-289533-hip9qtu5.txt txt: ./txt/cord-289533-hip9qtu5.txt summary: Since this disease is considered an immunosuppressive status by itself, especially in some types of cancer, the medical community has become increasingly concerned about the potentially deleterious effects that COVID-19 infection may cause in these patients. However, the limited current medical evidence suggests that there is no reason to believe that merely a history of thyroid cancer is enough to have an increased risk of developing COVID-19 infection or to evolve into a poor outcome. The frequency and modality of surveillance for patients with thyroid cancer in the COVID-19 pandemic must be adapted according to the risk of recurrence and the response to treatment. Patients with an excellent, indeterminate, or biochemical incomplete response to treatment do not constitute a risk group for COVID-19 infection, and the frequency of structural disease is less than 4%, 15%, and 20%, respectively [14] . abstract: The recent coronavirus infectious disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is placing health systems in serious challenges worldwide. Shocking statistics each day has prompted the World Health Organization to officially declare the COVID-19 outbreak as a pandemic in March 2020. Preliminary studies have shown increased mortality in patients with solid cancers and infection by SARS-CoV-2. Until now, the evidence on the behavior of COVID-19 in patients with a history of thyroid cancer remains scarce, and most of the recommendations given are based on common sense. Therefore, in this viewpoint, we present a brief review of several challenges we are frequently facing during this pandemic and a series of recommendations based on what we have implemented in our clinical practice at a university hospital currently mostly dedicated to COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32754886/ doi: 10.1007/s12020-020-02439-6 id: cord-295800-w0dup04b author: So, Loletta K-Y title: Development of a standard treatment protocol for severe acute respiratory syndrome date: 2003-05-10 words: 2401.0 sentences: 140.0 pages: flesch: 50.0 cache: ./cache/cord-295800-w0dup04b.txt txt: ./txt/cord-295800-w0dup04b.txt summary: Add combination treatment with ribavirin and methylprednisolone when: q Extensive or bilateral chest radiographic involvement q Or persistent chest radiographic involvement and persistent high fever for 2 days q Or clinical, chest radiographic, or laboratory findings suggestive of worsening q Or oxygen saturation <95% in room air Standard corticosteroid regimen for 21 days q Methylprednisolone 1 mg/kg every 8 h (3 mg/kg daily) intravenously for 5 days q Then methylprednisolone 1 mg/kg every 12 h (2 mg/kg daily) intravenously for 5 days q Then prednisolone 0·5 mg/kg twice daily (1 mg/kg daily) orally for 5 days q Then prednisolone 0·5 mg/kg daily orally for 3 days q Then prednisolone 0·25 mg/kg daily orally for 3 days q Then off Ribavirin regimen for 10-14 days q Ribavirin 400 mg every 8 h (1200 mg daily) intravenously for at least 3 days (or until condition becomes stable) q Then ribavirin 1200 mg twice daily (2400 mg daily) orally Pulsed methylprednisolone q Give pulsed methylprednisolone if clinical condition, chest radiograph, or oxygen saturation worsens (at least two of these), and lymphopenia persists q Give as methylprednisolone 500 mg twice daily intravenously for 2 days, then back to standard corticosteroid regimen Ventilation q Consider non-invasive ventilation or mechanical ventilation if oxygen saturation <96% while on >6 L per min oxygen or if patient complains of increasing shortness of breath conditioning) was increased to 10-12 changes per h. abstract: A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterials and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series. url: https://www.ncbi.nlm.nih.gov/pubmed/12747883/ doi: 10.1016/s0140-6736(03)13265-5 id: cord-275272-qdg8sqpy author: Soares-Júnior, José Maria title: Gynecology and women’s health care during the COVID-19 pandemic: Patient safety in surgery and prevention date: 2020-06-16 words: 2038.0 sentences: 132.0 pages: flesch: 45.0 cache: ./cache/cord-275272-qdg8sqpy.txt txt: ./txt/cord-275272-qdg8sqpy.txt summary: In this context, based on a recent publication regarding patient safety in elective surgeries (9) (10) (11) , as well as on the law of access to treatment and laws related to women''s health care (23, 24) , we propose the inclusion of gynecological surgery cases, stratified as follows ( Figure 1 ): Emergency (o1h): Peritonitis by tubo-ovarian and/or pelvic abscess, necrotizing fasciitis in surgeries for pelvic and breast neoplasms; DOI: 10.6061/clinics/2020/e2063 Urgent (o24h): Postoperative infections, acute inflammatory abdomen (adnexal tortoise, myoma tortoise, ovarian cysts), hemorrhagic conditions (ovarian cysts); Elective urgent (o2 weeks): Surgeries for neoplasms of the lower genital tract and breast previously diagnosed by pathological examination; Essential Elective (42 to o3 months): Hysteroscopy for abnormal uterine bleeding (unknowledge causes, suspected malignancy, and menopausal transition), postmenopausal bleeding (suspected malignancy), cervical conization or looped electro excision procedure (to exclude neoplasm in the lower genital tract); Non-essential/elective surgery: Infertility procedures, family planning procedures (bilateral tubal ligation procedure). abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32578830/ doi: 10.6061/clinics/2020/e2063 id: cord-032928-m0awip9y author: Sobh, Eman title: Novel coronavirus disease 2019 (COVID-19) non-respiratory involvement date: 2020-10-01 words: 4021.0 sentences: 242.0 pages: flesch: 43.0 cache: ./cache/cord-032928-m0awip9y.txt txt: ./txt/cord-032928-m0awip9y.txt summary: Coronavirus disease 2019 (COVID-19) is caused by a novel single-strand ribonucleic acid (RNA) coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 primary attacks the lower respiratory system causing viral pneumonia, but it may also affect the heart, gastrointestinal system, liver, kidney, and central nervous system leading to multiple organ failure [3] . Other researchers found elevated serum troponin levels in many patients infected with COVID-19, and it was associated with more severe disease and poor prognosis [21] . The mechanism behind acute myocardial injury caused by SARS-CoV-2 infection might be related to human angiotensin-converting enzyme 2 receptor (ACE2) [20] which are highly expressed in the heart [11] . The results of previous reports indicate that cardiac injury, arrhythmia, and venous thromboembolism should be considered in any suspected or confirmed COVID-19 case and the patient should undergo a prompt clinical evaluation. abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a newly emerging pandemic that affected millions of people worldwide caused by novel coronavirus SARS-CoV-2. The first cases reported suffered from respiratory symptoms. MAIN BODY: Various extrapulmonary manifestations were linked to COVID-19 in several reports including cardiovascular, genitourinary, gastrointestinal, and skin. It is important that every clinician should be aware of these non-respiratory manifestations for early diagnosis and prompt management. This review aims to summarize the different extrapulmonary manifestations of COVID-19 disease and highlight the importance of multidisciplinary care. CONCLUSION: COVID-19 is a disease of multi-organ involvement. Manifestations may vary depending on which organ is involved. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527290/ doi: 10.1186/s43168-020-00030-1 id: cord-323293-4gmnkg09 author: Sobhani, Navid title: Mutant p53 as an Antigen in Cancer Immunotherapy date: 2020-06-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The p53 tumor suppressor plays a pivotal role in cancer and infectious disease. Many oncology treatments are now calling on immunotherapy approaches, and scores of studies have investigated the role of p53 antibodies in cancer diagnosis and therapy. This review summarizes the current knowledge from the preliminary evidence that suggests a potential role of p53 as an antigen in the adaptive immune response and as a key monitor of the innate immune system, thereby speculating on the idea that mutant p53 antigens serve as a druggable targets in immunotherapy. Except in a few cases, the vast majority of published work on p53 antibodies in cancer patients use wild-type p53 as the antigen to detect these antibodies and it is unclear whether they can recognize p53 mutants carried by cancer patients at all. We envision that an antibody targeting a specific mutant p53 will be effective therapeutically against a cancer carrying the exact same mutant p53. To corroborate such a possibility, a recent study showed that a T cell receptor-like (TCLR) antibody, initially made for a wild-type antigen, was capable of discriminating between mutant p53 and wild-type p53, specifically killing more cancer cells expressing mutant p53 than wild-type p53 in vitro and inhibiting the tumour growth of mice injected with mutant p53 cancer cells than mice with wild-type p53 cancer cells. Thus, novel antibodies targeting mutant p53, but not the wild-type isoform, should be pursued in preclinical and clinical studies. url: https://doi.org/10.3390/ijms21114087 doi: 10.3390/ijms21114087 id: cord-256856-jw1d6uig author: Sohinki, Daniel title: What Coronavirus Disease 2019 Has Taught Us About Modern Electrophysiology Practice date: 2020-08-15 words: 2070.0 sentences: 104.0 pages: flesch: 40.0 cache: ./cache/cord-256856-jw1d6uig.txt txt: ./txt/cord-256856-jw1d6uig.txt summary: EP seems uniquely suited to adopt telemedicine as a care delivery platform as an undeniably technical specialty that is increasingly reliant on objective, preacquired data in a manner that does not require the patient to physically interact with a physician to share in clinical decision-making (Figure 1) . 1 A large study using Consumer Assessment of Healthcare Providers and Systems data demonstrated no difference in patient satisfaction when comparing in-person and telehealth visits. These results can then be communicated to the physician via electronic health records, fax, secure messaging, or the telemedicine platform itself, thereby ensuring longitudinal care. Today, however, with the advent of smartphone and smartwatch technologies, consumer electronics have become an attractive modality for ambulatory ECG recording, capable of rapid, high-quality rhythm strip acquisition and transmission, enabling remote physician review. Patient satisfaction management in office visits and telehealth in health care technology. abstract: nan url: https://doi.org/10.19102/icrm.2020.110801 doi: 10.19102/icrm.2020.110801 id: cord-287544-n32iscmr author: Solaimanzadeh, Isaac title: Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19 date: 2020-05-12 words: 5448.0 sentences: 282.0 pages: flesch: 41.0 cache: ./cache/cord-287544-n32iscmr.txt txt: ./txt/cord-287544-n32iscmr.txt summary: title: Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19 A retrospective review was conducted on CCB use in hospitalized patients in search of any difference in outcomes related to specific endpoints: survival to discharge and progression of disease leading to intubation and mechanical ventilation. Nifedipine and amlodipine were found to be associated with significantly improved mortality and a decreased risk for intubation and mechanical ventilation in elderly patients hospitalized with COVID-19. Nifedipine and amlodipine were found to be associated with significantly improved mortality and a decreased risk for intubation and mechanical ventilation in elderly patients hospitalized with COVID-19. A retrospective review of patients on either nifedipine or amlodipine was conducted in search of any difference in outcomes, including survival to discharge and progression of disease leading to intubation and mechanical ventilation. abstract: Dihydropyridine calcium channel blockers (CCB) are typically used agents in the clinical management of hypertension. Yet, they have also been utilized in the treatment of various pulmonary disorders with vasoconstriction. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been implicated in the development of vasoconstrictive, proinflammatory, and pro-oxidative effects. A retrospective review was conducted on CCB use in hospitalized patients in search of any difference in outcomes related to specific endpoints: survival to discharge and progression of disease leading to intubation and mechanical ventilation. The electronic medical records for all patients that tested positive for SARS-CoV-2 that were at or above the age of 65 and that expired or survived to discharge from a community hospital in Brooklyn, NY, between the start of the public health crisis due to the viral disease up until April 13, 2020, were included. Of the 77 patients that were identified, 18 survived until discharge and 59 expired. Seven patients from the expired group were excluded since they died within one day of presentation to the hospital. Five patients were excluded from the expired group since their age was above that of the eldest patient in the survival group (89 years old). With 65 patients left, 24 were found to have been administered either amlodipine or nifedipine (CCB group) and 41 were not (No-CCB group). Patients treated with a CCB were significantly more likely to survive than those not treated with a CCB: 12 (50%) survived and 12 expired in the CCB group vs. six (14.6%) that survived and 35 (85.4%) that expired in the No-CCB treatment group (P<.01; p=0.0036). CCB patients were also significantly less likely to undergo intubation and mechanical ventilation. Only one patient (4.2%) was intubated in the CCB group whereas 16 (39.0%) were intubated in the No-CCB treatment group (P<.01; p=0.0026). Nifedipine and amlodipine were found to be associated with significantly improved mortality and a decreased risk for intubation and mechanical ventilation in elderly patients hospitalized with COVID-19. Further clinical studies are warranted. Including either nifedipine or amlodipine in medication regimens for elderly patients with hypertension hospitalized for COVID-19 may be considered. url: https://www.ncbi.nlm.nih.gov/pubmed/32411566/ doi: 10.7759/cureus.8069 id: cord-334188-bggt1i2e author: Solari, Domenico title: The nose lid for the endoscopic endonasal procedures during COVID-19 era: technical note date: 2020-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: COVID-19 pandemic has disrupted the global health systems worldwide. According to the tremendous rate of interhuman transmission via aerosols and respiratory droplets, severe measures have been required to contain contagion spread. Accordingly, medical and surgical maneuvers involving the respiratory mucosa and, among them, transnasal transsphenoidal surgery have been charged of maximum risk of spread and contagion, above all for healthcare professionals. METHOD: Our department, according to the actual COVID-19 protocol national guidelines, has suspended elective procedures and, in the last month, only three patients underwent to endoscopic endonasal procedures, due to urgent conditions (a pituitary apoplexy, a chondrosarcoma causing cavernous sinus syndrome, and a pituitary macroadenoma determining chiasm compression). We describe peculiar surgical technique modifications and the use of an endonasal face mask, i.e., the nose lid, to be applied to the patient during transnasal procedures for skull base pathologies as a further possible COVID-19 mitigation strategy. RESULTS: The nose lid is cheap, promptly available, and can be easily assembled with the use of few tools available in the OR; this mask allows to both operating surgeon and his assistant to perform wider surgical maneuvers throughout the slits, without ripping it, while limiting the nostril airflow. CONCLUSIONS: Transnasal surgery, transgressing respiratory mucosa, can definitely increase the risk of virus transmission: we find that adopting further precautions, above all limiting high-speed drill can help preventing or at least reducing aerosol/droplets. The creation of a non-rigid face mask, i.e., the nose lid, allows the comfortable introduction of instruments through one or both nostrils and, at the same time, minimizes the release of droplets from the patient’s nasal cavity. url: https://www.ncbi.nlm.nih.gov/pubmed/32779028/ doi: 10.1007/s00701-020-04518-z id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 words: 98961.0 sentences: 5553.0 pages: flesch: 54.0 cache: ./cache/cord-014464-m5n250r2.txt txt: ./txt/cord-014464-m5n250r2.txt summary: Results In preliminary analysis of categorical data, a signifi cantly (Fisher exact test) greater proportion of patients with compared with without the following fi ndings did not survive; history of alcohol use (P = 0.05); the presence of lethargy (P = 0.01), confusion (P = 0.03), nausea (P = 0.04), abdominal pain (P = 0.02), or the need for vasopressors (P = 0.002), oxygen, mechanical ventilation, or steroids (all P = 0.004) at presentation; and excessive bleeding at surgery (P = 0.01). Methods To prospectively re-evaluate the normal range and to analyze the potential impact of biometric data on ICG-PDR, we measured ICG-PDR (i.v. injection of 0.25 mg/kg ICG; LiMON, Pulsion, Munich, Introduction Mixed venous oxygen saturation (SVO 2 ) represents a well-recognized parameter of oxygen delivery (DO 2 )-consumption (VO 2 ) mismatch and its use has been advocated in critically ill patients in order to guide hemodynamic resuscitation [1] and oxygen delivery optimization. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642469/ doi: 10.1186/cc11953 id: cord-341197-e8m4oxma author: Soleimani, Abbas title: Effects of angiotensin receptor blockers (ARBs) on in-hospital outcomes of patients with hypertension and confirmed or clinically suspected COVID-19 date: 2020-09-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: There is an ongoing controversy about harms and benefits of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in hypertensive patients with coronavirus disease 2019 (COVID-19). Given the unresolved debate, we investigated the association of ARBs with in-hospital outcomes of these patients. METHODS: In this retrospective observational study, we studied patients with COVID-19 who referred to Sina Hospital in Tehran, Iran, from February 20 to May 29, 2020. Patients with either positive real-time reverse-transcriptase polymerase-chain-reaction test of swab specimens, or high clinical suspicion according to the World Health Organization's interim guidance were included. We followed-up patients for incurring death, severe COVID-19, and in-hospital complications. RESULTS: We evaluated 681 patients with COVID-19 of whom 37 patients were excluded due to incomplete medical records and 8 patients who used ACEIs which left 636 patients in the analysis. In this cohort, 108 (17.0%) patients expired and 407 (64.0%) patients incurred severe COVID-19. Of 254 (39.9%) patients with hypertension, 122 (48.0%) patients were receiving an ARB. After adjustment for possible confounders, we found no independent association between taking ARBs and in-hospital outcomes except for acute kidney injury (AKI), in patients with confirmed or clinically suspected COVID-19, either hypertensive or not-hypertensive. We found that discontinuation of ARBs during hospitalization was associated with a greater risk of mortality, invasive ventilation, and AKI (All P˂0.002). CONCLUSIONS: We found that taking ARBs by patients with hypertension and confirmed or clinically suspected COVID-19 is not associated with poorer in-hospital outcomes after adjustment for possible confounders. url: https://www.ncbi.nlm.nih.gov/pubmed/32920644/ doi: 10.1093/ajh/hpaa149 id: cord-269031-sz8ieltb author: Solé, G title: Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network date: 2020-04-20 words: 5744.0 sentences: 245.0 pages: flesch: 37.0 cache: ./cache/cord-269031-sz8ieltb.txt txt: ./txt/cord-269031-sz8ieltb.txt summary: Abstract In France, the epidemic phase of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in February 2020 and resulted in the implementation of emergency measures and a degradation in the organization of neuromuscular reference centers. In the context of NM diseases, particular attention must be paid to two experimental COVID-19 treatments, hydroxycholoroquine and azithromycin: risk of exacerbation of myasthenia gravis and QT prolongation in patients with pre-existing cardiac involvement. In France, the epidemic phase of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in February 2020 and resulted in the implementation of emergency measures and a degradation in the organization of neuromuscular reference centers. The main addressed topics pertain to the disease itself, its mode of transmission, the official national public health recommendations to prevent it, the behaviors to adopt in case symptoms appear, and its consequences specific to the neuromuscular patient (e.g., relating to the management of steroids and immunosuppressor treatments, medical appointments, rehabilitation, and 6 ventilation). abstract: Abstract In France, the epidemic phase of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in February 2020 and resulted in the implementation of emergency measures and a degradation in the organization of neuromuscular reference centers. In this special context, the French Rare Health Care for Neuromuscular Diseases Network (FILNEMUS) has established guidance in an attempt to homogenize the management of neuromuscular (NM) patients within the French territory. Hospitalization should be reserved for emergencies, the conduct of treatments that cannot be postponed, check-ups for which the diagnostic delay may result in a loss of survival chance, and cardiorespiratory assessments for which the delay could be detrimental to the patient. A national strategy was adopted during a period of 1 to 2 months concerning treatments usually administered in hospitalization. NM patients treated with steroid/ immunosuppressants for a dysimmune pathology should continue all of their treatments in the absence of any manifestations suggestive of COVID-19. A frequently asked questions (FAQ) sheet has been compiled and updated on the FILNEMUS website. Various support systems for self-rehabilitation and guided exercises have been also provided on the website. In the context of NM diseases, particular attention must be paid to two experimental COVID-19 treatments, hydroxycholoroquine and azithromycin: risk of exacerbation of myasthenia gravis and QT prolongation in patients with pre-existing cardiac involvement. The unfavorable emergency context related to COVID-19 may specially affect the potential for intensive care admission (ICU) for people with NMD. In order to preserve the fairest medical decision, a multidisciplinary working group has listed the neuromuscular diseases with a good prognosis, usually eligible for resuscitation admission in ICU and, for other NM conditions, the positive criteria suggesting a good prognosis. Adaptation of the use of noninvasive ventilation (NIV) make it possible to limit nebulization and continue using NIV in ventilator-dependent patients. url: https://doi.org/10.1016/j.neurol.2020.04.004 doi: 10.1016/j.neurol.2020.04.004 id: cord-292620-t8ocqm6g author: Somani, S. title: Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19 date: 2020-05-22 words: 2768.0 sentences: 171.0 pages: flesch: 48.0 cache: ./cache/cord-292620-t8ocqm6g.txt txt: ./txt/cord-292620-t8ocqm6g.txt summary: Methods and Findings: Retrospective cohort study of patients with confirmed SARS-CoV-2 discharged alive from five hospitals in New York City with index hospitalization between February 27th-April 12th, 2020, with follow-up of [≥]14 days. Of 2,864 discharged patients, 103 (3.6%) returned for emergency care after a median of 4.5 days, with 56 requiring inpatient readmission. Patients who returned had higher proportion of COPD and hypertension with shorter LOS on index hospitalization, and a trend towards lower rates of in-hospital treatment-dose anticoagulation. . https://doi.org/10.1101/2020.05.17.20104604 doi: medRxiv preprint Certain index hospitalization laboratory values on discharge differed among patients who returned vs. Finally, returning patients had shorter LOS on index hospitalization with notably a lower frequency of ICU care and inpatient anticoagulation. Among patients discharged following admission for COVID-19, the rate of return to hospital was relatively low, with only half requiring readmission. abstract: Background: Data on patients with coronavirus disease 2019 (COVID-19) who return to hospital after discharge are scarce. Characterization of these patients may inform post-hospitalization care. Methods and Findings: Retrospective cohort study of patients with confirmed SARS-CoV-2 discharged alive from five hospitals in New York City with index hospitalization between February 27th-April 12th, 2020, with follow-up of [≥]14 days. Significance was defined as P<0.05 after multiplying P by 125 study-wide comparisons. Of 2,864 discharged patients, 103 (3.6%) returned for emergency care after a median of 4.5 days, with 56 requiring inpatient readmission. The most common reason for return was respiratory distress (50%). Compared to patients who did not return, among those who returned there was a higher proportion of COPD (6.8% vs 2.9%) and hypertension (36% vs 22.1%). Patients who returned also had a shorter median length of stay (LOS) during index hospitalization (4.5 [2.9,9.1] vs. 6.7 [3.5, 11.5] days; Padjusted=0.006), and were less likely to have required intensive care on index hospitalization (5.8% vs 19%; Padjusted=0.001). A trend towards association between absence of in-hospital anticoagulation on index admission and return to hospital was also observed (20.9% vs 30.9%, Padjusted=0.064). On readmission, rates of intensive care and death were 5.8% and 3.6%, respectively. Conclusions: Return to hospital after admission for COVID-19 was infrequent within 14 days of discharge. The most common cause for return was respiratory distress. Patients who returned had higher proportion of COPD and hypertension with shorter LOS on index hospitalization, and a trend towards lower rates of in-hospital treatment-dose anticoagulation. Future studies should focus on whether these comorbid conditions, longer LOS and anticoagulation are associated with reduced readmissions. url: http://medrxiv.org/cgi/content/short/2020.05.17.20104604v1?rss=1 doi: 10.1101/2020.05.17.20104604 id: cord-260274-c3586tp6 author: Somers, Emily C title: Tocilizumab for treatment of mechanically ventilated patients with COVID-19 date: 2020-07-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Severe COVID-19 can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers, consistent with cytokine release syndrome for which IL-6 blockade is approved treatment. METHODS: We assessed effectiveness and safety of IL-6 blockade with tocilizumab in a single-center cohort of patients with COVID-19 requiring mechanical ventilation. The primary endpoint was survival probability post-intubation; secondary analyses included an ordinal illness severity scale integrating superinfections. Outcomes in patients who received tocilizumab compared to tocilizumab-untreated controls were evaluated using multivariable Cox regression with propensity score inverse probability weighting (IPTW). RESULTS: 154 patients were included, of whom 78 received tocilizumab and 76 did not. Median follow-up was 47 days (range 28-67). Baseline characteristics were similar between groups, although tocilizumab-treated patients were younger (mean 55 vs. 60 years), less likely to have chronic pulmonary disease (10% vs. 28%), and had lower D-dimer values at time of intubation (median 2.4 vs. 6.5 mg/dL). In IPTW-adjusted models, tocilizumab was associated with a 45% reduction in hazard of death [hazard ratio 0.55 (95% CI 0.33, 0.90)] and improved status on the ordinal outcome scale [odds ratio per 1-level increase: 0.58 (0.36, 0.94)]. Though tocilizumab was associated with an increased proportion of patients with superinfections (54% vs. 26%; p<0.001), there was no difference in 28-day case fatality rate among tocilizumab-treated patients with versus without superinfection [22% vs. 15%; p=0.42]. Staphylococcus aureus accounted for ~50% of bacterial pneumonia. CONCLUSIONS: In this cohort of mechanically ventilated COVID-19 patients, tocilizumab was associated with lower mortality despite higher superinfection occurrence. url: https://doi.org/10.1093/cid/ciaa954 doi: 10.1093/cid/ciaa954 id: cord-311000-abntwzuy author: Sommer, Adir C. title: Telemedicine in ophthalmology in view of the emerging COVID-19 outbreak date: 2020-08-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Technological advances in recent years have resulted in the development and implementation of various modalities and techniques enabling medical professionals to remotely diagnose and treat numerous medical conditions in diverse medical fields, including ophthalmology. Patients who require prolonged isolation until recovery, such as those who suffer from COVID-19, present multiple therapeutic dilemmas to their caregivers. Therefore, utilizing remote care in the daily workflow would be a valuable tool for the diagnosis and treatment of acute and chronic ocular conditions in this challenging clinical setting. Our aim is to review the latest technological and methodical advances in teleophthalmology and highlight their implementation in screening and managing various ocular conditions. We present them as well as potential diagnostic and treatment applications in view of the recent SARS-CoV-2 virus outbreak. METHODS: A computerized search from January 2017 up to March 2020 of the online electronic database PubMed was performed, using the following search strings: “telemedicine,” “telehealth,” and “ophthalmology.” More generalized complementary contemporary research data regarding the COVID-19 pandemic was also obtained from the PubMed database. RESULTS: A total of 312 records, including COVID-19-focused studies, were initially identified. After exclusion of non-relevant, non-English, and duplicate studies, a total of 138 records were found eligible. Ninety records were included in the final qualitative analysis. CONCLUSION: Teleophthalmology is an effective screening and management tool for a range of adult and pediatric acute and chronic ocular conditions. It is mostly utilized in screening of retinal conditions such as retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration; in diagnosing anterior segment condition; and in managing glaucoma. With improvements in image processing, and better integration of the patient’s medical record, teleophthalmology should become a more accepted modality, all the more so in circumstances where social distancing is inflicted upon us. [Image: see text] url: https://doi.org/10.1007/s00417-020-04879-2 doi: 10.1007/s00417-020-04879-2 id: cord-330918-hsy8h1vb author: Song, Jia title: A Comparison of Clinical Characteristics and Outcomes in Elderly and Younger Patients with COVID-19 date: 2020-07-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The aim of this study was to describe the clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and compare these parameters in an elderly group with those in a younger group. MATERIAL/METHODS: This retrospective, single-center observational study included 69 hospitalized patients with laboratory-confirmed COVID-19 from a tertiary hospital in Wuhan, China, between January 14, 2020, and February 26, 2020. Epidemiological, demographic, clinical, and laboratory data, as well as treatments, complications, and outcomes were extracted from electronic medical records and compared between elderly patients (aged ≥60 years) and younger patients (aged <60 years). Patients were followed until March 19, 2020. RESULTS: Elderly patients had more complications than younger patients, including acute respiratory distress syndrome (ARDS; 9/25, 36% vs. 5/44, 11.4%) and cardiac injury (7/25, 28% vs. 1/44, 2.3%), and they were more likely to be admitted to the intensive care unit (6/25, 24% vs. 2/44, 4.5%). As of March 19, 2020, 60/69 (87%) of the patients had been discharged, 6/69 (8.7%) had died, and 3/69 (4.3%) remained in the hospital. Of those who were discharged or died, the median duration of hospitalization was 13.5 days (interquartile range, 10–18 days). CONCLUSIONS: Elderly patients with confirmed COVID-19 were more likely to develop ARDS and cardiac injury than younger patients and were more likely to be admitted to the intensive care unit. In addition to routine monitoring and respiratory support, cardiac monitoring and supportive care should be a focus in elderly patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32720649/ doi: 10.12659/msm.925047 id: cord-032181-gmcugd8h author: Song, Jian-Xin title: Main Complications of AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 words: 51165.0 sentences: 2516.0 pages: flesch: 37.0 cache: ./cache/cord-032181-gmcugd8h.txt txt: ./txt/cord-032181-gmcugd8h.txt summary: 3. Hepatorenal syndrome, which is characterized by renal failure, hemodynamic changes in arterial circulation and abnormalities in the endogenous vascular system, is a common clinical complication of end-stage liver disease, and one of the important indicators for the prognosis of patients with severe hepatitis. The latest report indicated that basic laboratory examinations for coagulation function testing in common use at present, such as PT, APTT, international normalized ratio (INR) etc., have little correlation with occurrence of gastrointestinal bleeding in these patients, thereby revealing the importance to search and pay close attention to those complicating disease upregulating bleeding risk, such as bacterial infection, renal failure, hemodynamic change after portal hypertension, dysfunction of endotheliocyte as well as macrophagocyte and so on [107] . abstract: This chapter describes the clinical features, and diagnosis of complications in AECHB including secondary bacterial infections, coagulation disorder, water electrolyte disorder, hepatorenal syndrome, hepatic encephalopathy, hepatopulmonary syndrome and endotoxemia: 1. Patients with severe hepatitis have impaired immunity and are therefore vulnerable to all kinds of infections. After infection, these patients may experience shock, DIC and multiple organ failure, all of which seriously affect their prognosis and are major causes of death. Concurrent infections consist primarily of infections of the lungs, intestines, biliary tract, and urinary tract, as well as spontaneous bacterial peritonitis and sepsis. 2. Severe hepatitis may reduce the synthesis of coagulation factors and enhance their dysfunction and increase anticoagulants and platelet abnormalities, leading to coagulopathy. Infection, hepatorenal syndrome and complications can further aggravate coagulopathy, resulting in DIC and seriously affecting patient prognosis. 3. Hepatorenal syndrome, which is characterized by renal failure, hemodynamic changes in arterial circulation and abnormalities in the endogenous vascular system, is a common clinical complication of end-stage liver disease, and one of the important indicators for the prognosis of patients with severe hepatitis. 4. Water electrolyte disorder (water retention, hyponatremia, hypokalemia, hyperkalaemia) and acid-base imbalance are common in patients with severe hepatitis. These internal environment disorders can lead to exacerbation and complication of the illness. 5. Hepatic encephalopathy is a neurological and psychiatric anomaly syndrome based on metabolic disorder, and an important prognostic indicator for patients with severe hepatitis. 6. The hepatopulmonary syndrome is an important vascular complication in lungs due to systemic hypoxemia in patients with cirrhosis and portal hypertension. The majority of patients with HPS are asymptomatic. Long-term oxygen therapy remains the most frequently recommended therapy for symptoms in patients with severe hypoxemia. 7. Endotoxemia, an important complication of severe hepatitis, is not only a second hit to the liver, but also leads to other complications including SIRS and MODS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498917/ doi: 10.1007/978-94-024-1603-9_2 id: cord-342809-wrxejwms author: Song, Jungeun title: Characteristics of First Visit Pediatric Patients with Suicidal Ideation and Behavior: An 8-Year Retrospective Chart Review date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: Our study aimed to analyze the demographic and clinical characteristics of children and adolescents during their first visit to psychiatric outpatient departments for the management of suicidal ideation and behavior, and to compare the changes before and in 2012 or later. METHODS: This multicenter study was conducted at five university hospitals in a metropolitan area in South Korea. Medical records of patients aged 6–18 years were retrospectively reviewed from January 2009 to December 2016. Patients were analyzed by classifying them into suicidal and non-suicidal groups based on their visit to the hospital for management of suicidal ideation or suicide attempt and other mental problems, respectively. RESULTS: There were differences in the year of visit, diagnosis, education level, and referral sources between patients in the suicidal and non-suicidal groups. Multiple regression analysis was conducted based on the sex, education level, referral by school, and diagnosis of depression in patients in the suicidal group, which revealed significant association. CONCLUSION: Suicide-related problems were significantly associated with the sex, education level, referral by school, and a diagnosis of depression in the patients. A well-connected referral system would be necessary for professional mental health management of high-risk children and adolescents. url: https://www.ncbi.nlm.nih.gov/pubmed/33110355/ doi: 10.5765/jkacap.200029 id: cord-320632-369kax2m author: Song, Yang title: COVID-19 Treatment: Close to a Cure? – A Rapid Review of Pharmacotherapies for the Novel Coronavirus date: 2020-07-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Currently, there is no approved therapy for COVID-19. The World Health Organization therefore endorse supportive care only. However, frontline clinicians and researchers have been experimenting with several virus-based and host-based therapeutics since the outbreak in China. China's National Health Commission has issued the first COVID-19 Treatment Guideline with therapy suggestions (7(th) edition attached) which inspired following clinical studies worldwide. Major therapeutics are evaluated in this review. Key evidence from in vitro researches, animal models and clinical researches in emerging coronaviruses are examined. Antiviral therapies remdesivir, lopinavir/ritonavir and umifenovir, if considered, could be initiated before the peak of viral replication for optimal outcomes. Ribavirin may be beneficial as an add-on therapy and is ineffective as a monotherapy. Corticosteroids use should be limited to indicating comorbidities. IVIG is not recommended due to lack of data in COVID-19. Xuebijing may benefit patients with complications of bacterial pneumonia or sepsis. The efficacy of interferon is unclear due to conflicting outcomes in coronavirus studies. Chloroquine and hydroxychloroquine have shown in vitro inhibition of SARS-CoV-2, and the studies on clinical efficacy and whether the benefits outweigh the risk of dysrhythmias remain inconclusive. For patients who developed cytokine release syndrome, interleukin-6 inhibitors may be beneficial. url: https://www.ncbi.nlm.nih.gov/pubmed/32634603/ doi: 10.1016/j.ijantimicag.2020.106080 id: cord-252531-i3b647wv author: Song, Zaiwei title: Hospital pharmacists’ pharmaceutical care for hospitalized patients with COVID-19: Recommendations and guidance from clinical experience date: 2020-04-03 words: 3531.0 sentences: 180.0 pages: flesch: 31.0 cache: ./cache/cord-252531-i3b647wv.txt txt: ./txt/cord-252531-i3b647wv.txt summary: Results Hospital pharmacists shall support pharmaceutical care services by participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, providing strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy, providing emotional counselling and psychological support, and providing scientific information about COVID-19 vaccines. For COVID-19 patients receiving centralized hospitalized treatment, pharmaceutical care services are https://doi.org/10.1016/j.sapharm.2020.03.027 Received 31 March 2020; Accepted 31 March 2020 indispensable supplement for clinical treatment and management, which is of great significance for improving the level of drug therapy, improving patient''s outcome and promoting the overall pandemic control. Based on the Chinese perspective of "centralizing COVID-19 patients and centralized inpatient treatment", the paper established a pharmaceutical care framework of COVID-19 hospitalized patients, including participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy (CPT), providing emotional counselling and psychological support and providing scientific information about COVID-19 vaccines. abstract: Abstract Objective To discuss hospital pharmacists’ role in providing pharmaceutical care for hospitalized patients with COVID-19 to promote patient care and management during the pandemic. Method Based on the method of evidence-based pharmacy, clinical evidence of therapeutical drugs for COVID-19 were retrieved and summarized. Based on clinical experience Chinese hospital pharmacists gained from providing pharmaceutical care services during COVID-19 pandemic, taking COVID-19 hospitalized patients’ needs into consideration, the methods and strategies hospital pharmacists shall use to provide pharmaceutical care were analyzed and summarized. Results Hospital pharmacists shall support pharmaceutical care services by participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, providing strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy, providing emotional counselling and psychological support, and providing scientific information about COVID-19 vaccines. Conclusion The need of pharmaceutical care services in COVID-19 hospitalized patients during this pandemic was quite distinguished from the past. Hospital pharmacists shall join the collaborative multidisciplinary team to improve COVID-19 patients’ outcome and reduce mortality, and to facilitate the pandemic control. url: https://www.sciencedirect.com/science/article/pii/S1551741120303144 doi: 10.1016/j.sapharm.2020.03.027 id: cord-281804-lhnw8jx5 author: Sonis, Jonathan D. title: Humanism in the Age of COVID-19: Renewing Focus on Communication and Compassion date: 2020-04-24 words: 1987.0 sentences: 99.0 pages: flesch: 42.0 cache: ./cache/cord-281804-lhnw8jx5.txt txt: ./txt/cord-281804-lhnw8jx5.txt summary: While video and telephonic alternatives to bedside evaluation may facilitate communication with patients while maintaining physical separation to limit healthcare worker exposure and preserve PPE, these solutions may not be as effective in older patients, who commonly have hearing and visual impairment, challenges with manual dexterity due to arthritis, and cognitive impairment, all of which impede effective use of such technology. 22 Not only will reducing variability improve adherence to isolation and other outpatient management recommendations, but providing frontline staff with comprehensive, pre-written instructions reduces the work burden associated with individual patient discharges and allows for the inclusion of extended information surrounding expected disease course, follow-up planning, and support resources for those suffering from the psychological effects of isolation or requiring local resources such as access to food. abstract: nan url: https://doi.org/10.5811/westjem.2020.4.47596 doi: 10.5811/westjem.2020.4.47596 id: cord-254993-bndl93qr author: Sonnweber, Thomas title: Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study date: 2020-10-21 words: 3684.0 sentences: 192.0 pages: flesch: 41.0 cache: ./cache/cord-254993-bndl93qr.txt txt: ./txt/cord-254993-bndl93qr.txt summary: To shed light on the regulation of iron metabolism and its impact on monocyte immune effector functions at the cellular level, we investigated the mRNA expression of key mediators of iron homeostasis as well as cytokine expression in PBMCs. In line with serum hepcidin measurements, we also found increased hepcidin mRNA (HAMP, for hepcidin antimicrobial peptide) expression in PBMCs isolated from subjects who previously had severe to critical COVID-19 as compared to those who suffered from milder disease (Fig. 2) . In contrast, the immune effector function of PBMCs was related to COVID-19 severity, as mononuclear cells obtained from patients, who suffered from severe to critical disease, demonstrated higher levels of interleukin 10 (IL10, p = 0.044) and tumour necrosis factor (TNF, p = 0.024) mRNA expression as compared to subjects with a milder course of COVID-19 (Fig. 2) . abstract: BACKGROUND: Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmetabolism is mechanistically linked to COVID-19 pathobiology. METHODS: We herein present data from the ongoing prospective, multicentre, observational CovILD cohort study (ClinicalTrials.gov number, NCT04416100), which systematically follows up patients after COVID-19. 109 participants were evaluated 60 days after onset of first COVID-19 symptoms including clinical examination, chest computed tomography and laboratory testing. RESULTS: We investigated subjects with mild to critical COVID-19, of which the majority received hospital treatment. 60 days after disease onset, 30% of subjects still presented with iron deficiency and 9% had anemia, mostly categorized as anemia of inflammation. Anemic patients had increased levels of inflammation markers such as interleukin-6 and C-reactive protein and survived a more severe course of COVID-19. Hyperferritinemia was still present in 38% of all individuals and was more frequent in subjects with preceding severe or critical COVID-19. Analysis of the mRNA expression of peripheral blood mononuclear cells demonstrated a correlation of increased ferritin and cytokine mRNA expression in these patients. Finally, persisting hyperferritinemia was significantly associated with severe lung pathologies in computed tomography scans and a decreased performance status as compared to patients without hyperferritinemia. DISCUSSION: Alterations of iron homeostasis can persist for at least two months after the onset of COVID-19 and are closely associated with non-resolving lung pathologies and impaired physical performance. Determination of serum iron parameters may thus be a easy to access measure to monitor the resolution of COVID-19. TRIAL REGISTRATION: ClinicalTrials.gov number: NCT04416100. url: https://www.ncbi.nlm.nih.gov/pubmed/33087116/ doi: 10.1186/s12931-020-01546-2 id: cord-255197-79yfslu1 author: Soo, Chun Ian title: Telehealth: “virtual” lifeline for home-ventilated patients during the COVID-19 pandemic date: 2020-09-28 words: 1155.0 sentences: 63.0 pages: flesch: 38.0 cache: ./cache/cord-255197-79yfslu1.txt txt: ./txt/cord-255197-79yfslu1.txt summary: title: Telehealth: "virtual" lifeline for home-ventilated patients during the COVID-19 pandemic Telehealth appears useful to fill in the void for home-ventilated patients to maintain the much-needed connectivity with their healthcare team during the #COVID19 pandemic https://bit.ly/3ftvjxW The emergence of PAP devices also resulted in a higher number of patients requiring long-term medical care and ventilation. HMV support generally comprises a mobile healthcare team (HCT), which delivers services to the patient at their homes or long-term care facility. In contrast, telehealth is an umbrella term that encompasses telemedicine and the distribution of nonclinical services such as medical information and provider training [4] . Through information and communications technology, telehealth provides a network link to enable remote collaboration between the patient or their caregivers and HCTs, who are geographically separated. Technological advances in home non-invasive ventilation monitoring: reliability of data and effect on patient outcomes abstract: Telehealth appears useful to fill in the void for home-ventilated patients to maintain the much-needed connectivity with their healthcare team during the #COVID19 pandemic https://bit.ly/3ftvjxW url: https://www.ncbi.nlm.nih.gov/pubmed/33015149/ doi: 10.1183/23120541.00399-2020 id: cord-312572-i7r28wdc author: Sosnowski, Roman title: Uro-oncology in the era of social distancing: the principles of patient-centered online consultations during the COVID-19 pandemic date: 2020-07-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The COVID-19 pandemic poses significant challenges to healthcare facilities and as per social distancing measures, many consultations are now being carried out via means of telemedicine. As some urologists may not be skilled with remote consultations, there is a need for recommendations on patient-centered online medical counseling. MATERIAL AND METHODS: We have identified eight areas of excellence and defined the principles based on our experience. RESULTS: A professional setting should be provided, in which the privacy of the patient can be ensured. Accompanying persons should be encouraged into the consultation. Proper introduction could serve not only to verify the personality of the patient, but also to provide them with a sense of confidentiality. The interview should be held in a way to overcome the limitations of non-physical encounters, and pande-mic-specific issues should be taken into consideration. When arranging plans, the physician should judge accordingly in regards to what type of management is inevitable or safe, as well as available at this point; strict follow-up should be arranged. As home isolation may lead to unfavorable changes in lifestyle, this issue should be addressed too. The patient should be guided on how to self-educate. Concluding the visit should be aimed at proper evaluation of the patient’s comprehension of the consultation. CONCLUSIONS: It is vital to pursue consistency in providing care to patients. While online counseling may seem challenging, if one adheres to the principles of patient-centered practice, telemedicine may become a valuable tool in maintaining the best-quality care amid the ongoing pandemic. url: https://doi.org/10.5173/ceju.2020.0171 doi: 10.5173/ceju.2020.0171 id: cord-261921-c97ygxq2 author: Souders, Colby P. title: Considerations for Bedside Urologic Procedures in Patients with Severe Acute Respiratory Syndrome Coronavirus-2 date: 2020-04-24 words: 1826.0 sentences: 94.0 pages: flesch: 42.0 cache: ./cache/cord-261921-c97ygxq2.txt txt: ./txt/cord-261921-c97ygxq2.txt summary: METHODS: Urologic trainees and attending physicians at our institution, who are familiar with existing safety recommendations and guidelines regarding the care of infected patients, were queried regarding their experiences to determine an expert consensus on best practices for bedside procedures for SARS-CoV-2 positive patients. RESULTS: Our team developed the following general recommendations for urologic interventions on SARS-CoV-2 positive patients: maximize use of telehealth (even for inpatient consults), minimize in-room time, use personal protective equipment appropriately, enlist a colleague to assist, and acquire all supplies that may be needed and maintain them outside the room. Our aim is to share our experiences performing bedside urologic procedures on SARS-CoV-2positive patients and offer considerations to maximize the safety of the patients and providers involved and conserve supplies while maintaining a high standard of care. Outlined above are our experiences with inpatient consultations and bedside procedures in SARS-CoV-2 patients and how we have attempted to address urologic challenges that have emerged with this pandemic. abstract: OBJECTIVE: To provide guidance when performing bedside urologic procedures on SARS-CoV-2 positive patients and offer considerations to maximize the safety of the patients and providers, conserve supplies, and provide optimal management of urologic issues. METHODS: Urologic trainees and attending physicians at our institution, who are familiar with existing safety recommendations and guidelines regarding the care of infected patients, were queried regarding their experiences to determine an expert consensus on best practices for bedside procedures for SARS-CoV-2 positive patients. RESULTS: Our team developed the following general recommendations for urologic interventions on SARS-CoV-2 positive patients: maximize use of telehealth (even for inpatient consults), minimize in-room time, use personal protective equipment appropriately, enlist a colleague to assist, and acquire all supplies that may be needed and maintain them outside the room. Detailed recommendations were also developed for difficult urethral catheterization, bedside cystoscopy, incision and drainage of abscesses, and gross hematuria/clot irrigations. CONCLUSIONS: As patients hospitalized with SARS-CoV-2 infection are predominantly men over 50 years old, there are significant urologic challenges common in this population that have emerged with this pandemic. While there is tremendous variation in how different regions have been affected, the demographics of SARS-CoV-2 mean that urologists will continue to have a unique role in helping to manage these patients. Here, we summarize recommendations for bedside urologic interventions specific to SARS-CoV-2 positive patients based on experiences from a large metropolitan hospital system. Regulations and requirements may differ on an institutional basis, so these guidelines are intended to augment specific local protocols. url: https://www.ncbi.nlm.nih.gov/pubmed/32339561/ doi: 10.1016/j.urology.2020.04.066 id: cord-267402-kca05rvz author: South, Kieron title: Preceding infection and risk of stroke: An old concept revived by the COVID-19 pandemic date: 2020-07-24 words: 6248.0 sentences: 335.0 pages: flesch: 41.0 cache: ./cache/cord-267402-kca05rvz.txt txt: ./txt/cord-267402-kca05rvz.txt summary: What follows herein is a detailed summary of the current literature surrounding COVID-19, encompassing the immune and inflammatory responses to infection, thrombotic manifestations and vascular consequences of infection with a focus on possible mechanisms by which these elements may contribute to acute stroke events. 89 This is not the case in COVID-19 (and the previous SARS outbreak) and a recent retrospective cohort study has suggested an incidence of stroke 7-8 times higher in patients hospitalized with COVID-19 infection compared with those hospitalized by influenza, 90 supporting the possibility of a SARS-CoV-2-driven hyper-coagulant state. [91] [92] [93] Obesity, in particular, is emerging as a prominent risk factor in the development of severe COVID-19 disease and is generally associated with increased incidence and increased severity of respiratory viral infection. Notably, the cytokine IL-33 is persistently elevated in obese individuals and is capable of stimulating endothelial cells to release pro-coagulant tissue factor 97 which may expose them to more severe COVID-19 disease and/or stroke. abstract: Anecdotal reports and clinical observations have recently emerged suggesting a relationship between COVID-19 disease and stroke, highlighting the possibility that infected individuals may be more susceptible to cerebrovascular events. In this review we draw on emerging studies of the current pandemic and data from earlier, viral epidemics, to describe possible mechanisms by which SARS-CoV-2 may influence the prevalence of stroke, with a focus on the thromboinflammatory pathways, which may be perturbed. Some of these potential mechanisms are not novel but are, in fact, long-standing hypotheses linking stroke with preceding infection that are yet to be confirmed. The current pandemic may present a renewed opportunity to better understand the relationship between infection and stroke and possible underlying mechanisms. url: https://www.ncbi.nlm.nih.gov/pubmed/32618498/ doi: 10.1177/1747493020943815 id: cord-342519-tjr6dvtt author: Souza, Thiago Moreno L. title: H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis date: 2010-11-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The novel influenza A pandemic virus (H1N1pdm) caused considerable morbidity and mortality worldwide in 2009. The aim of the present study was to evaluate the clinical course, duration of viral shedding, H1N1pdm evolution and emergence of antiviral resistance in hospitalized cancer patients with severe H1N1pdm infections during the winter of 2009 in Brazil. METHODS: We performed a prospective single-center cohort study in a cancer center in Rio de Janeiro, Brazil. Hospitalized patients with cancer and a confirmed diagnosis of influenza A H1N1pdm were evaluated. The main outcome measures in this study were in-hospital mortality, duration of viral shedding, viral persistence and both functional and molecular analyses of H1N1pdm susceptibility to oseltamivir. RESULTS: A total of 44 hospitalized patients with suspected influenza-like illness were screened. A total of 24 had diagnosed H1N1pdm infections. The overall hospital mortality in our cohort was 21%. Thirteen (54%) patients required intensive care. The median age of the studied cohort was 14.5 years (3–69 years). Eighteen (75%) patients had received chemotherapy in the previous month, and 14 were neutropenic at the onset of influenza. A total of 10 patients were evaluated for their duration of viral shedding, and 5 (50%) displayed prolonged viral shedding (median 23, range = 11–63 days); however, this was not associated with the emergence of a resistant H1N1pdm virus. Viral evolution was observed in sequentially collected samples. CONCLUSIONS: Prolonged influenza A H1N1pdm shedding was observed in cancer patients. However, oseltamivir resistance was not detected. Taken together, our data suggest that severely ill cancer patients may constitute a pandemic virus reservoir with major implications for viral propagation. url: https://doi.org/10.1371/journal.pone.0014158 doi: 10.1371/journal.pone.0014158 id: cord-294336-fqobpo47 author: Soy, Mehmet title: Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic date: 2020-06-25 words: 5792.0 sentences: 279.0 pages: flesch: 38.0 cache: ./cache/cord-294336-fqobpo47.txt txt: ./txt/cord-294336-fqobpo47.txt summary: This paper aims to review the pathogenesis and the clinical picture of HLH, and its severe complication, the cytokine storm, with a special emphasis on the developed classification criteria sets for rheumatologists, since COVID-19 infection has clinical symptoms resembling those of the common rheumatologic conditions and possibly triggers HLH. Hemophagocytic lymphohistiocytosis (HLH) comprises two different conditions that may be difficult to distinguish from one another: A primary form that occurs due to genetic disorders and a secondary form that is triggered by various infections, autoimmune/autoinflammatory diseases, or chemicals [1, 2] . In this review, we aim to contribute to the rheumatologists'' awareness of the life-threatening rare complication of HLH, the cytokine storm, to prevent a possible misdiagnosis in the presence of the clinical and laboratory features of COVID-19 resembling or mimicking to that of an underlying or a new-onset rheumatological condition. abstract: Hemophagocytic syndrome (HPS) or hemophagocytic lymphohistiocytosis (HLH) is an acute and rapidly progressive systemic inflammatory disorder characterized by cytopenia, excessive cytokine production, and hyperferritinemia. Common clinical manifestations of HLH are acute unremitting fever, lymphadenopathy, hepatosplenomegaly, and multiorgan failure. Due to a massive cytokine release, this clinical condition is considered as a cytokine storm syndrome. HPS has primary and acquired (secondary, reactive) forms. Its primary form is mostly seen in childhood and caused by various mutations with genetic inheritance and, therefore, is called familial HLH. Secondary HLH may be caused in the presence of an underlying disorder, that is, secondary to a malignant, infectious, or autoimmune/autoinflammatory stimulus. This paper aims to review the pathogenesis and the clinical picture of HLH, and its severe complication, the cytokine storm, with a special emphasis on the developed classification criteria sets for rheumatologists, since COVID-19 infection has clinical symptoms resembling those of the common rheumatologic conditions and possibly triggers HLH. MED-LINE/Pubmed was searched from inception to April 2020, and the following terms were used for data searching: “hemophagocytic syndrome” OR “macrophage activation syndrome” OR “hemophagocytic lymphohistiocytosis”, OR “cytokine storm”. Finally, AND “COVID-19” was included in this algorithm. The selection is restricted to the past 5 years and limited numbers of earlier key references were manually selected. Only full-text manuscripts, published in an English language peer-reviewed journal were included. Manuscript selection procedure and numbers are given in Fig. 2. Briefly, the database search with the following terms of “Hemophagocytic syndrome” OR “Macrophage activation syndrome” OR “Hemophagocytic lymphohistiocytosis” OR “Cytokine storm” yielded 6744 results from inception to April 2020. The selection is restricted to the past 5 years and only limited numbers of earlier key references were selected, and this algorithm resulted in 3080 manuscripts. The addition of (AND “COVID-19”) resulted in 115 publications of which 47 studies, together with four sections of an online book were used in the final review. No statistical method was used. HLH is triggered by genetic conditions, infections, malignancies, autoimmune-autoinflammatory diseases, and some drugs. In COVID-19 patients, secondary HLH and cytokine storm may be responsible for unexplained progressive fever, cytopenia, ARDS, neurological and renal impairment. Differentiation between the primary and secondary forms of HLH is utterly important, since primary form of HLH requires complicated treatments such as hematopoietic stem cell transplantation. Further studies addressing the performance of HScore and other recommendations in the classification of these patients is necessary. url: https://doi.org/10.1007/s00296-020-04636-y doi: 10.1007/s00296-020-04636-y id: cord-347607-ydbyonbg author: Spagnuolo, Rocco title: COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background and objectives: Spreading of SARS-CoV-2 infection from China to countries with a higher prevalence of inflammatory bowel disease (IBD) has generated concern among gastroenterologists and patients. The aim of this survey is to evaluate knowledge about clinical importance of COVID-19, disease management, prevention measures, and anxiety level during pandemic among patients with IBD. Material and methods: From 15th March to 15th April 2020, a questionnaire survey was administered to 200 patients with IBD by email or phone application. The questionnaire consisted of five sections: (1) anthropometric, demographic and clinical characteristics, (2) knowledge about clinical importance of COVID-19, (3) IBD management, (4) prevention measures, (5) anxiety level during pandemic. Results: One hundred forty two questionnaires were completed. Ninety-seven patients (68.3%) were males with a mean age of 46 years (SD 13; range 17–76). Fifty-four individuals (38%) were affected by Crohn disease and 88 (62%) by Ulcerative Colitis. Most patients reported high knowledge about clinical importance of COVID-19 (80%), IBD management (72%), and prevention measures (97%). Sixty-two percent of them showed moderate-high level of anxiety. High education level was independently associated with high knowledge about clinical importance of COVID-19 (odds ratio [OR] 5, 95% confidence interval [CI] 1.49–16.6, p = 0.009) and older age (OR 1, 95%, CI 1.01–1.1, p = 0.01), while the receipt of e-format educational material with low knowledge about clinical importance of COVID-19 (OR 3, 95%, CI 1.08–9.3, p = 0.03). Displaying an active disease appeared to be independently associated with low knowledge of IBD management (OR 5.8, 95% CI 1.4–22.8, p = 0.01) and no variables other than an older age was independently associated with higher level of anxiety (OR 1.04, 95% CI 1.009–1.09, p = 0.01). Conclusions: High educational level and aging promote knowledge about clinical importance of COVID-19, while e-format educational material does not. Taken together with findings that an active disease status compromises knowledge of IBD management and the high level of anxiety related to increasing age, these data suggest the need of further supporting patient-oriented strategies in IBD during Covid-19 pandemic. url: https://doi.org/10.3390/medicina56080407 doi: 10.3390/medicina56080407 id: cord-005420-60ie0pfd author: Sparrelid, E title: Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection date: 1998-10-09 words: 3830.0 sentences: 223.0 pages: flesch: 47.0 cache: ./cache/cord-005420-60ie0pfd.txt txt: ./txt/cord-005420-60ie0pfd.txt summary: title: Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection Episodes of bacteraemia during the aplastic phase were studied in 500 allogeneic bone marrow (BMT) recipients, regarding incidence, microbial aetiology, risk factors, mortality and causes of death. Among patients with negative blood cultures during the aplastic phase, 6/25 died of invasive fungal infection (three candida, one saccaromyces and two aspergillus). Invasive candida infection was defined as either candidaemia, and/or positive cultures from at least two organs, except the gastrointestinal tract when obtained at autopsy, in patients who died within 60 days after BMT. Risk factors analysed were recipient age and gender, donor age and gender, pretransplant diagnosis, disease stage (low risk for transplantation-related mortality (TRM): acute leukaemia in 1st complete remission, CML 1st chronic phase, aplastic anaemia, metabolic disorders; high risk for TRM: others), pretransplant serology for cytomegalovirus (CMV) and herpes simplex virus (HSV) in the recipient, HLAmatch, related and unrelated donors, conditioning regimen (TBI or not), splenectomy, type of GVHD prophylaxis and bone marrow cell dose. abstract: Episodes of bacteraemia during the aplastic phase were studied in 500 allogeneic bone marrow (BMT) recipients, regarding incidence, microbial aetiology, risk factors, mortality and causes of death. One hundred and sixty-four patients (33%) had at least one positive blood culture. Gram-positive cocci (α-streptococci and coagulase-negative staphylococci) were found in 146/164 cases (89%). Gram-negative bacteria were present in only seven cases. Receiving marrow from an unrelated donor was the only significant risk factor for bacteraemia in univariate regression analysis. Within 60 days after BMT, 69/500 patients died. The mortality rate was significantly higher among those with positive blood cultures during the aplastic phase, 44/164 (27%) than in those without bacteraemia, 25/336 (7%). Death directly caused by sepsis was unusual in patients with α-streptococci or CNS-bacteraemia (8/146, 5%). In contrast, three of seven patients with gram-negative bacteraemia died of the infection. However, in patients with bacteraemia, 21 of 44 deaths were attributable to invasive fungal infections (18 candida, three aspergillus; autopsy findings). Among patients with negative blood cultures during the aplastic phase, 6/25 died of invasive fungal infection (three candida, one saccaromyces and two aspergillus). This indicates that early bacteraemia is associated with death from invasive fungal infection. Therefore, efforts to shorten the neutropenic period after BMT, prevention, early detection of invasive fungal infections and adjustments of immnosuppressive regimens when marrow from an unrelated donor is used, may improve the outcome after BMT. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091628/ doi: 10.1038/sj.bmt.1701404 id: cord-016110-mlwe7fzz author: Specks, Ulrich title: Pulmonary Manifestations of Vasculitis date: 2014-05-05 words: 7833.0 sentences: 415.0 pages: flesch: 36.0 cache: ./cache/cord-016110-mlwe7fzz.txt txt: ./txt/cord-016110-mlwe7fzz.txt summary: In the context of a vasculitis syndrome, the lungs and lower airways can be affected by three major pathologic processes: (1) infl ammatory cell infi ltration and necrosis of the pulmonary parenchyma; (2) infl ammation of the tracheobronchial tree often leading to stenoses; and (3) pulmonary capillaritis causing diffuse alveolar hemorrhage (DAH). DAH can result from a variety of underlying or associated conditions that cause a disruption of the alveolarcapillary basement membrane integrity including immunological infl ammatory conditions causing immune-complex deposition or capillaritis (e.g., anti-GBM disease (Goodpasture''s), systemic lupus erythematosus (SLE), ANCA-associated vasculitis), direct chemical/toxic injury (e.g., from toxic or chemical inhalation, abciximab use, all-trans-retinoic acid, trimellitic anhydride, or smoked crack cocaine), physical trauma (e.g., pulmonary contusion), and increased vascular pressure within the capillaries (e.g., mitral stenosis or severe left ventricular failure) (Table 10 .1 ). abstract: Respiratory manifestations in patients with a primary systemic vasculitis syndrome need to be separated into those caused by the vasculitis itself, those related to treatment complications, and those caused by unrelated or only indirectly related comorbidities such as obstructive sleep apnea. Respiratory tract involvement is most common in the ANCA-associated vasculitides. Respiratory manifestations are less frequent and less prominent in other forms of systemic vasculitis, but they may nevertheless represent significant management challenges and carry a poor prognosis. This chapter reviews the tracheobronchial and pulmonary parenchymal disease manifestations, their clinical presentation, and differential diagnosis for each of the vasculitis syndromes. A systematic differential diagnostic approach to the patient with diffuse alveolar hemorrhage is also provided. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120293/ doi: 10.1007/978-1-4939-0770-0_10 id: cord-282183-k0pn0ie2 author: Spiezia, Luca title: More severe hypercoagulable state in acute COVID-19 pneumonia as compared to other pneumonia. date: 2020-10-01 words: 1724.0 sentences: 98.0 pages: flesch: 43.0 cache: ./cache/cord-282183-k0pn0ie2.txt txt: ./txt/cord-282183-k0pn0ie2.txt summary: Interestingly, we and two other Italian groups recently reported hypercoagulable whole blood profiles in COVID-19 patients admitted to Intensive Care Units for acute respiratory failure [4] [5] [6] . Therefore, we aimed to study traditional and whole blood thromboelastometry profiles -via a ROTEM ® sigma apparatus (Instrumentation Laboratory Werfen, Barcelona, Spain) -in a group of patients consecutively admitted to Internal Medicine wards of Padova University Hospital for acute pneumonia: cases were COVID-19 patients with pneumonia and controls were patients with pneumonia from different etiology. Although several papers, including one by our group, have previously reported COVID-19-related hypercoagulability in patients admitted to Intensive Care Units 4-6 , the present study focuses more closely on the comparison of coagulation profiles between COVID-19 patients with acute pneumonia and non COVID-19 patients with acute pneumonia. abstract: Objective To conduct a comprehensive evaluation of coagulation profiles — via traditional and whole blood thromboelastometry tests — in COVID-19 positive vs. COVID-19 negative patients admitted to medical wards for acute pneumonia. Patients and Methods We enrolled all consecutive patients admitted to Internal Medicine wards of Padova University Hospital between 7 March and 30 April 2020 for COVID-19-related pneumonia (cases) vs. non-COVID-19 pneumonia (controls). A group of healthy subjects acted as baseline for thromboelastometry parameters. Results Fifty-six cases (mean age 64±15 yrs, M/F 37/19) and 56 controls (mean age 76±11 yrs, M/F 35/21) were enrolled. Cases and controls showed markedly hypercoagulable thromboelastometry profiles vs. healthy subjects, mainly characterized by a significantly shorter propagation phase of coagulation (Clot Formation Time, CFT) and significantly increased maximum clot firmness (MCF) (p <0.001 in all comparisons). COVID-19 patients with pneumonia had significantly shorter CFT and higher MCF (p <0.01 and <0.05, respectively in all comparisons) vs. controls. Conclusion Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself. url: https://www.sciencedirect.com/science/article/pii/S2542454820301855?v=s5 doi: 10.1016/j.mayocpiqo.2020.09.002 id: cord-353281-leb7c7b0 author: Spiezia, Luca title: COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure date: 2020-04-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In late December 2019 an outbreak of a novel coronavirus (SARS-CoV-2) causing severe pneumonia (COVID-19) was reported in Wuhan, Hubei Province, China. A common finding in most COVID-19 patients is high D-dimer levels which are associated with a worse prognosis. We aimed to evaluate coagulation abnormalities via traditional tests and whole blood thromboelastometry profiles in a group of 22 (mean age 67 ± 8 years, M:F 20:2) consecutive patients admitted to the Intensive Care Unit of Padova University Hospital for acute respiratory failure due to COVID-19. Cases showed significantly higher fibrinogen and D-dimer plasma levels versus healthy controls ( p < 0.0001 in both comparisons). Interestingly enough, markedly hypercoagulable thromboelastometry profiles were observed in COVID-19 patients, as reflected by shorter Clot Formation Time (CFT) in INTEM ( p = 0.0002) and EXTEM ( p = 0.01) and higher Maximum Clot Firmness (MCF) in INTEM, EXTEM and FIBTEM ( p < 0.001 in all comparisons). In conclusion, COVID-19 patients with acute respiratory failure present a severe hypercoagulability rather than consumptive coagulopathy. Fibrin formation and polymerization may predispose to thrombosis and correlate with a worse outcome. url: https://doi.org/10.1055/s-0040-1710018 doi: 10.1055/s-0040-1710018 id: cord-028709-r1inj3ra author: Spinazzola, Giorgia title: Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study date: 2020-07-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Neurally adjusted ventilatory assist (NAVA) is an innovative mode for assisted ventilation that improves patient-ventilator interaction in children. The aim of this study was to assess the effects of patient-ventilator interaction comparing NAVA with pressure support ventilation (PSV) in patients difficult to wean from mechanical ventilation after moderate pediatric acute respiratory distress syndrome (PARDS). METHODS: In this physiological crossover study, 12 patients admitted in the Pediatric Intensive Care Unit (PICU) with moderate PARDS failing up to 3 spontaneous breathing trials in less than 7 days, were enrolled. Patients underwent three study conditions lasting 1 h each: PSV1, NAVA and PSV2. RESULTS: The Asynchrony Index (AI) was significantly reduced during the NAVA trial compared to both the PSV1 and PSV2 trials (p = 0.001). During the NAVA trial, the inspiratory and expiratory trigger delays were significantly shorter compared to those obtained during PSV1 and PSV2 trials (Delay(trinsp)p < 0.001, Delay(trexp)p = 0.013). These results explain the significantly longer Time(sync) observed during the NAVA trial (p < 0.001). In terms of gas exchanges, PaO(2) value significantly improved in the NAVA trial with respect to the PSV trials (p < 0.02). The PaO(2)/FiO(2) ratio showed a significant improvement during the NAVA trial compared to both the PSV1 and PSV2 trials (p = 0.004). CONCLUSIONS: In this specific PICU population, presenting difficulty in weaning after PARDS, NAVA was associated with a reduction of the AI and a significant improvement in oxygenation compared to PSV mode. TRIAL REGISTRATION: ClinicalTrial.gov Identifier: NCT04360590 “Retrospectively registered”. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338290/ doi: 10.1186/s12887-020-02227-1 id: cord-335759-io18c6z0 author: Sprik, Petra title: Feasibility and acceptability of a telephone-based chaplaincy intervention in a large, outpatient oncology center date: 2020-07-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Telechaplaincy (the use of telecommunications and virtual technology to deliver spiritual and religious care by healthcare chaplains or other religious/spiritual leaders) is a relatively novel intervention that has increasingly been used in recent years, and especially during COVID-19. Telephone-based chaplaincy is one mode of telechaplaincy. The purpose of this study was to (1) describe telephone-based chaplaincy interventions delivered as the first point of contact to patients who screen positive for religious/spiritual concern(s) using an electronic data system, and (2) assess the feasibility and acceptability of delivering interventions in an outpatient cancer institute using this methodology. METHODS: Patients were screened for religious and spiritual (R/S) concern(s) using an electronic data system. Patients indicating R/S concern(s) were offered a telephone-based chaplaincy intervention and asked to complete a survey assessing acceptability of the intervention. Feasibility and acceptability data were collected. RESULTS: Thirty percent of screened patients indicated R/S concern(s). Telephone-based chaplaincy interventions were offered to 100% of eligible patients, establishing contact with 61% of eligible patients, and offering chaplaincy interventions to 48% of those patients. Survey participants report high acceptability of the offered intervention. CONCLUSION: This is the first study examining feasibility and acceptability of telephone-based chaplaincy with oncology patients. Telephone-based chaplaincy is feasible and acceptable within an outpatient oncology setting, supporting the promise of this interventional strategy. Further research is needed to refine practices. url: https://doi.org/10.1007/s00520-020-05598-4 doi: 10.1007/s00520-020-05598-4 id: cord-342603-k0f33p3l author: Spyropoulos, Alex C. title: Scientific and Standardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID‐19 date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus disease of 2019 (COVID‐19) pandemic, as declared by the World Health Organization, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2). Cardiovascular disease and, in particular, venous thromboembolism (VTE) has emerged as an important consideration in the management of hospitalized patients with COVID‐19. The diagnosis of VTE using standardized objective testing is problematic in these patients, given the risk of infecting non‐COVID‐19 hospitalized patients and hospital personnel, coupled with the usual challenges of performing diagnostic testing in critically‐ill patients. Early reports suggest a high incidence of VTE in hospitalized COVID‐19 patients, particularly those with severe illness, that is similar to the high VTE rates observed in patients with other viral pneumonias, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS‐CoV). url: https://www.ncbi.nlm.nih.gov/pubmed/32459046/ doi: 10.1111/jth.14929 id: cord-274557-2071770h author: Späth, Peter J. title: On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events date: 2015-02-05 words: 10243.0 sentences: 530.0 pages: flesch: 40.0 cache: ./cache/cord-274557-2071770h.txt txt: ./txt/cord-274557-2071770h.txt summary: i.e., cold-ethanol or ion-exchange chromatography, contaminants, route of application, i.e., intra muscular (IMIG), intravenous (IVIG), or subcutaneous (SCIG), the rate of increase of the exogenous IgG in the circulation of the recipient over time and, last but not least an eventually existing risk factor from patients'' side ( Figure 1 ) as well as incorrect handling of the concentrate are factors having a role in inducing non-infectious AEs related to administration of IgG concentrates ( Table 1) . The complement-mediated AEs were considered to be caused by aggregates in the product ("spontaneous complement activation" or anti-complementary activity or ACA) or by in vivo formation of immune complexes (ICs, patient''s condition related; e.g., subclinical infections or the unnoticed presence of anti-IgA antibodies) and therefore only IgG concentrates with low or absent ACA is accepted by authorities for human use. abstract: Therapy by human immunoglobulin G (IgG) concentrates is a success story ongoing for decades with an ever increasing demand for this plasma product. The success of IgG concentrates on a clinical level is documented by the slowly increasing number of registered indication and the more rapid increase of the off-label uses, a topic dealt with in another contribution to this special issue of Frontiers in Immunology. A part of the success is the adverse event (AE) profile of IgG concentrates which is, even at life-long need for therapy, excellent. Transmission of pathogens in the last decade could be entirely controlled through the antecedent introduction by authorities of a regulatory network and installing quality standards by the plasma fractionation industry. The cornerstone of the regulatory network is current good manufacturing practice. Non-infectious AEs occur rarely and mainly are mild to moderate. However, in recent times, the increase in frequency of hemolytic and thrombotic AEs raised worrying questions on the possible background for these AEs. Below, we review elements of non-infectious AEs, and particularly focus on hemolysis and thrombosis. We discuss how the introduction of plasma fractionation by ion-exchange chromatography and polishing by immunoaffinity chromatographic steps might alter repertoire of specificities and influence AE profiles and efficacy of IgG concentrates. url: https://www.ncbi.nlm.nih.gov/pubmed/25699039/ doi: 10.3389/fimmu.2015.00011 id: cord-013116-n7auvqh3 author: Srinivas, A. title: Testing the limits of UDCs date: 2020-10-09 words: 794.0 sentences: 56.0 pages: flesch: 58.0 cache: ./cache/cord-013116-n7auvqh3.txt txt: ./txt/cord-013116-n7auvqh3.txt summary: authors: Srinivas, A.; Moshkun, C.; Darcey, J. History revealed that the 17 had been removed four months prior to presentation due to similarly vague symptoms. He had already begun a course of antibiotics and was using chlorhexidine mouth rinses prescribed remotely via an urgent dental centre (UDC). The pain had reduced but there was still discomfort in the area and the patient reported it to feel sharp on his tongue. The patient contacted UDHM six weeks later with ongoing pain and a face-to-face review was arranged. In that time he had not been offered a face-to-face review but rather been given a further two courses of antibiotics after remote UDC consultations. Reflecting back over this patient''s history and clinical encounters there were signs that may have pointed towards a nonodontogenic diagnosis. Darcey, Manchester, UK https://doi.org/10.1038/s41415-020-2226-y missing a serious diagnosis or misdiagnosing. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546146/ doi: 10.1038/s41415-020-2226-y id: cord-312249-k7dp776s author: Srinivasan, L. title: Split ventilation with pressure regulators for patient-specific tidal volumes date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As a measure of last resort during the COVID-19 pandemic, single mechanical ventilators have been repurposed to support multiple patients. In existing split-ventilator configurations using FDA-approved tubing adaptors, each patient receives the same inspiratory pressure, requiring careful matching of patients to avoid barotrauma. Progression of disease may cause tidal volumes to diverge from desired targets, and routine interventions (eg. suctioning) in one patient may adversely affect other patients. To overcome these limitations, we demonstrate a split-ventilator configuration that enables individualized patient management by incorporating a commonly available pressure regulator used for gas appliances. We validate this method by achieving various combinations of tidal volume in each of two synthetic lungs using a standard ventilator machine in combination with two gas flow analyzers. With further safety testing and instrumentation, pressure regulators may represent a viable path to substantially augment the capacity for ventilation in resource-constrained settings. url: http://medrxiv.org/cgi/content/short/2020.07.03.20145409v1?rss=1 doi: 10.1101/2020.07.03.20145409 id: cord-290041-zxlq63n5 author: Srivastava, Arnav title: Delaying Surgery for Clinical T1b-T2bN0M0 Renal Cell Carcinoma: Oncologic Implications in the COVID-19 Era and Beyond date: 2020-10-20 words: 2992.0 sentences: 184.0 pages: flesch: 50.0 cache: ./cache/cord-290041-zxlq63n5.txt txt: ./txt/cord-290041-zxlq63n5.txt summary: MATERIALS AND METHODS: We retrospectively abstracted cT1b-T2bN0M0 RCC patients from the National Cancer Database (NCDB), stratifying them by clinical stage and time from diagnosis to surgery. 1 These delayed surgeries include many potentially curative urologic oncologic surgeries 2, 3 , such as partial and radical nephrectomies for renal cell carcinoma (RCC), which remain the preferred curative treatment for localized kidney cancer. Our retrospective analysis using the NCDB is the largest study to date to examine the risks of surgical delay on up-staging and OS in cT1b-T2b RCC. 16 Additionally, our grouping points of <1 month, 1-3 months, >3 months were selected based on prior literature and our clinical practice during the COVID-19 pandemic where local institutions delayed most kidney cancer cases by 1-3 months. In most patients with clinically localized cT1b tumors, surgery may be safely delayed for up to 6 months without significant sacrifices in overall survival. Impact of Time-To-Surgery and Surgical Delay on Oncologic Outcomes for Renal Cell Carcinoma abstract: PURPOSE: During COVID-19, many operating rooms were reserved exclusively for emergent cases. As a result, many elective surgeries for renal cell carcinoma (RCC) were deferred, with an unknown impact on outcomes. Since surveillance is commonplace for small renal masses, we focused on larger, organ-confined RCCs. Our primary endpoint was pT3a up-staging and our secondary endpoint was overall survival (OS). MATERIALS AND METHODS: We retrospectively abstracted cT1b-T2bN0M0 RCC patients from the National Cancer Database (NCDB), stratifying them by clinical stage and time from diagnosis to surgery. We selected only those patients who underwent surgery. Patients were grouped by having surgery within 1 month, 1-3 months, or >3 months after diagnosis. Logistic regression models measured pT3a up-staging risk. Kaplan Meier curves and Cox proportional hazards models assessed OS. RESULTS: 29,746 patients underwent partial or radical nephrectomy. Delaying surgery >3 months after diagnosis did not confer pT3a up-staging risk among cT1b (OR=0.90; 95%CI: 0.77–1.05, p=0.170), cT2a (OR=0.90; 95%CI: 0.69–1.19, p=0.454), or cT2b (OR=0.96; 95%CI:0.62–1.51, p=0.873). In all clinical stage strata, non-clear cell RCCs were significantly less likely to be up-staged (p<0.001). A sensitivity analysis, performed for delays of <1, 1-3, 3-6, and >6 months, also showed no increase in up-staging risk. CONCLUSIONS: Delaying surgery up to, and even beyond, 3 months does not significantly increase risk of tumor progression in clinically localized RCC. However, if deciding to delay surgery due to COVID-19, tumor histology, growth kinetics, patient comorbidities, and hospital capacity/resources, should be considered. url: https://api.elsevier.com/content/article/pii/S1078143920304853 doi: 10.1016/j.urolonc.2020.10.012 id: cord-290326-umv0q4d7 author: Stachowska, Ewa title: Nutritional Support in Coronavirus 2019 Disease date: 2020-06-12 words: 5115.0 sentences: 241.0 pages: flesch: 40.0 cache: ./cache/cord-290326-umv0q4d7.txt txt: ./txt/cord-290326-umv0q4d7.txt summary: Consequently, due to lack of specific COVID-19 data, the recommendations in our review are based on viral and bacterial pneumonia studies, as well as recommendations made for critically ill patients. Nutritional treatment for critically ill patients diagnosed with COVID-19 (especially in case of respiratory and multiorgan failure) [22] is a key element of comprehensive treatment aimed to reduce the mortality. American Society for Parenteral and Enteral Nutrition (ASPEN) criteria for increased risk for aspiration are: inability to protect the airway, mechanical ventilation, age > 70 years, reduced level of consciousness, poor oral care, inadequate nurse: patient ratio, supine positioning, neurologic deficits, gastroesophageal reflux, transport out of the ICU, and use of bolus intermittent EN. Poor nutritional status is a prognostic factor for mortality in severe pneumonia and critical illness, especially for elderly patients. ESPEN and ASPEN guidelines for nutritional support in critical illness are applicable for COVID-19 patients requiring ICU support. abstract: The epidemic that broke out in Chinese Wuhan at the beginning of 2020 presented how important the rapid diagnosis of malnutrition (elevating during intensive care unit stay) and the immediate implementation of caloric and protein-balanced nutrition care are. According to specialists from the Chinese Medical Association for Parenteral and Enteral Nutrition (CSPEN), these activities are crucial for both the therapy success and reduction of mortality rates. The Chinese have published their recommendations including principles for the diagnosis of nutritional status along with the optimal method for nutrition supply including guidelines when to introduce education approach, oral nutritional supplement, tube feeding, and parenteral nutrition. They also calculated energy demand and gave their opinion on proper monitoring and supplementation of immuno-nutrients, fluids and macronutrients intake. The present review summarizes Chinese observations and compares these with the latest European Society for Clinical Nutrition and Metabolism guidelines. Nutritional approach should be an inseparable element of therapy in patients with COVID-19. url: https://doi.org/10.3390/medicina56060289 doi: 10.3390/medicina56060289 id: cord-261941-xf1k5uj1 author: Stackhouse, Robin A. title: Severe acute respiratory syndrome and tuberculosis date: 2005-03-01 words: 5420.0 sentences: 306.0 pages: flesch: 55.0 cache: ./cache/cord-261941-xf1k5uj1.txt txt: ./txt/cord-261941-xf1k5uj1.txt summary: Recommendations for limiting secondary transmission are given based on the Centers for Disease Control and Prevention guidelines on infection control in health care facilities. It is confirmed through laboratory testing showing an acute rise in SARS-CoV antibody titers within 4 weeks of developing the disease. Patients who meet the criteria for suspect SARS should immediately be placed in a private respiratory isolation room that has been specially engineered to contain negative pressure in relation to the outside hallway and have a minimum of 12 air exchanges per hour. Prevention of transmission in medical facilities requires a combination of early identification, isolation, and treatment of infectious individuals with active disease, engineering controls, basic infection control measures, and the use of personal protective equipment. Hospital infection control guidance for severe acute respiratory syndrome (SARS) California Department of Health Services: severe acute respiratory syndrome (SARS)-infection control recommendations Infection control measures for operative procedures in severe acute respiratory syndrome-related patients abstract: Respiratory infectious diseases such as severe acute respiratory syndrome and tuberculosis create unique risks for anyone who may be exposed. A brief history of each disease is discussed in this article. The pathogenesis, manifestations, and therapy (where applicable) are also addressed. Recommendations for limiting secondary transmission are given based on the Centers for Disease Control and Prevention guidelines on infection control in health care facilities. url: https://www.ncbi.nlm.nih.gov/pubmed/15325712/ doi: 10.1016/j.atc.2004.06.002 id: cord-280944-uphs5gvl author: Stagnell, S. title: COVID and consent date: 2020-07-10 words: 872.0 sentences: 54.0 pages: flesch: 54.0 cache: ./cache/cord-280944-uphs5gvl.txt txt: ./txt/cord-280944-uphs5gvl.txt summary: Sir, current guidance from the RCS Recommendations for paediatric dentistry during the COVID-19 pandemic is very clear: '' Access to general anaesthesia will be significantly reduced for the foreseeable future'' . Sir, prior to the COVID-19 pandemic, patients undergoing invasive procedures were subject to confirming their consent through written means, a process which is considered common within surgical fields. 1 The guidance issued by the FGDP on 1 June suggested a move towards provision of ''digital packs'' and it seems many standard operating procedures (SOPs) being issued by practices include the provision of digital information packs with consent forms to patients. With dental practices now resuming a limited level of practice and possibly experiencing the level of frustrations with lack of treatment provisions for anxious patients, oral sedation with Diazepam is an invaluable tool in enabling patients the access to care they require. Careful case selection is of course key to its successful use, and requires the triaging clinician to be thorough in ascertaining dental history and indication of sedation need. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32651488/ doi: 10.1038/s41415-020-1903-1 id: cord-290195-8uaai9nv author: Stebbing, Justin title: Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients date: 2020-05-30 words: 6584.0 sentences: 326.0 pages: flesch: 46.0 cache: ./cache/cord-290195-8uaai9nv.txt txt: ./txt/cord-290195-8uaai9nv.txt summary: Furthermore, baricitinib treatment resulted in a significant reduction (p<0.05) from baseline in plasma IL-6 at week 12 in patients with active RA who had an inadequate response to methotrexate from a phase 2b (Tanaka, Emoto et al., 2016) , randomized, placebo-controlled, dose-ranging study (Fig. 1B) . As shown in Figure 3A , all four patients showed improvement with baricitinib treatment in signs and symptoms such as cough, fever, and reduction in plasma IL-6 levels, along with a reduction in the SARS-CoV-2 RNA viral load, as detected by the real-time reverse-transcriptase-polymerase chain reaction (RT-PCR) signal from the nasopharyngeal carriage. Therefore, the impact of baricitinib on the subsequent development of protective humoral and cell-mediated anti-viral immunity in COVID-19 patients must be evaluated in randomized clinical trials (Ottoviani & Stebbing, 2020) . The finding that baricitinib is a potent AAK1/BIKE/GAK inhibitor that may reduce host cell infectivity, along with reaffirmation of its anti-cytokine profile, provide reasons to study this intervention in randomized clinical trials. abstract: Baricitinib, is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI)‐algorithms, to be useful for COVID‐19 infection via a proposed anti‐cytokine effects and as an inhibitor of host cell viral propagation. We evaluated the in vitro pharmacology of baricitinib across relevant leukocyte subpopulations coupled to its in vivo pharmacokinetics and showed it inhibited signaling of cytokines implicated in COVID‐19 infection. We validated the AI‐predicted biochemical inhibitory effects of baricitinib on human numb‐associated kinase (hNAK) members measuring nanomolar affinities for AAK1, BIKE, and GAK. Inhibition of NAKs led to reduced viral infectivity with baricitinib using human primary liver spheroids. These effects occurred at exposure levels seen clinically. In a case series of patients with bilateral COVID‐19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS‐CoV‐2 viral load, inflammatory markers, and IL‐6 levels. Collectively, these data support further evaluation of the anti‐cytokine and anti‐viral activity of baricitinib and supports its assessment in randomized trials in hospitalized COVID‐19 patients. url: https://doi.org/10.15252/emmm.202012697 doi: 10.15252/emmm.202012697 id: cord-297638-ab70s980 author: Stephens, Angela J. title: General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic date: 2020-04-28 words: 4515.0 sentences: 286.0 pages: flesch: 42.0 cache: ./cache/cord-297638-ab70s980.txt txt: ./txt/cord-297638-ab70s980.txt summary: 31 Additionally, this trial also demonstrated increased maternal morbidity, such as hemorrhage and infection, associated with expectant management of PPROM after 34 weeks that would further increase exposure to different medical personnel, movement between different hospital settings (i.e., labor, operating room, and intensive care unit), and overall length of stay. Although there has been a recent trend to allow a longer second stage of labor in hope of reducing the cesarean delivery rate due to failure to progress in the second stage, a prolonged second stage may be ill advised during the COVID-19 pandemic due to an increased risk of respiratory secretion exposures to visitors and medical personnel. An Analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks'' gestation: a multicentre randomized controlled trial (MICADO STUDY) abstract: Novel coronavirus disease 2019 (COVID-19) is a respiratory tract infection that was first identified in China. Since its emergence in December 2019, the virus has rapidly spread, transcending geographic barriers. The World Health Organization and the Centers for Disease Control and Prevention have declared COVID-19 as a public health crisis. Data regarding COVID-19 in pregnancy is limited, consisting of case reports and small cohort studies. However, obstetric patients are not immune from the current COVID-19 pandemic, and obstetric care will inevitably be impacted by the current epidemic. As such, clinical protocols and practice on labor and delivery units must adapt to optimize the safety of patients and health care workers and to better conserve health care resources. In this commentary, we provide suggestions to meet these goals without impacting maternal or neonatal outcomes. Key Points • Novel coronavirus disease 2019 (COVID-19) is a pandemic. • COVID-19 impacts care of obstetric patients. • Health care should be adapted for the COVID-19 pandemic. url: https://doi.org/10.1055/s-0040-1710308 doi: 10.1055/s-0040-1710308 id: cord-315297-o8mwmjql author: Stephens, Elizabeth H. title: COVID-19: Crisis Management in Congenital Heart Surgery date: 2020-04-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32302660/ doi: 10.1016/j.athoracsur.2020.04.001 id: cord-017302-xez0zso3 author: Stephens, R. Scott title: ICU Complications of Hematopoietic Stem Cell Transplant, Including Graft vs Host Disease date: 2019-07-24 words: 5226.0 sentences: 289.0 pages: flesch: 33.0 cache: ./cache/cord-017302-xez0zso3.txt txt: ./txt/cord-017302-xez0zso3.txt summary: Hematopoietic stem cell transplant (HSCT) has become an essential therapeutic modality in the treatment of malignant and non-malignant hematologic disease. Allogeneic transplants are associated with more morbidity and mortality than autologous transplants, and are further categorized based on conditioning regimen (myeloablative [MA] vs non-myeloablative [NMA]), donor-recipient relation (related vs unrelated), HLA matching (full match vs haploidentical vs mismatched), and stem cell source (bone marrow, peripheral blood, umbilical cord blood). Refinement of transplant techniques over the last 2 decades has dramatically decreased transplant-related mortality, but approximately 15% of HSCT patients require critical care [10] and earlier ICU admission has been associated with improved survival rates [11, 12] . Outcomes of stem cell transplant patients with acute respiratory failure requiring mechanical ventilation in the United States Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease abstract: Hematopoietic stem cell transplant (HSCT) is an essential treatment modality for many malignant and non-malignant hematologic diseases. Advances in HSCT techniques have dramatically decreased peri-transplant morbidity and mortality, but it remains a high-risk procedure, and a significant number of patients will require critical care during the transplant process. Complications of HSCT are both infectious and non-infectious, and the intensivist must be familiar with common infections, the management of neutropenic sepsis and septic shock, the management of respiratory failure in the immunocompromised host, and a plethora of HSCT-specific complications. Survival from critical illness after HSCT is improving, but the mortality rate remains unacceptably high. Continued research and optimization of critical care provision in this population should continue to improve outcomes. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121823/ doi: 10.1007/978-3-030-26710-0_80 id: cord-017420-tjwxec77 author: Stephens, R. Scott title: Neutropenic Fever in the Intensive Care Unit date: 2019-07-09 words: 5865.0 sentences: 290.0 pages: flesch: 34.0 cache: ./cache/cord-017420-tjwxec77.txt txt: ./txt/cord-017420-tjwxec77.txt summary: Neutropenic patients with septic shock tend to have more frequently positive blood cultures, more fungal infections, more multidrug-resistant bacterial infections, and higher mortality rates than immunocompetent patients. Accordingly, current guidelines for the management of neutropenic fever and sepsis recommend monotherapy with an antipseudomonal beta-lactam unless otherwise dictated by circumstances such as patient allergies, the presence of resistant organisms, or refractory hemodynamic instability [28, 57, 61] . The use of surveillance rectal cultures, performed pre-transplant and then weekly after HSCT, to identify patients with MDR infections and allow immediate initiation of antibiotic therapy targeted against MDR organisms may result in better outcomes [26] . Patients with neutropenia and sepsis are at high risk of developing multi-organ failure, particularly the acute respiratory distress syndrome (ARDS) [4, 5] . Neutropenic sepsis continues to confer a poor prognosis, with recent data suggesting an approximate 46% mortality rate in patients with hematologic malignancies who develop septic shock [7, 39, 47] . abstract: Neutropenic fever is a common and potentially life-threatening condition in patients treated for cancer. Rapid initiation of appropriate antimicrobial therapy is necessary to decrease the risk of mortality. Most infections are due to gram-positive organisms, but the mortality rate is higher for gram-negative infections. Multidrug-resistant organisms are an emerging threat to neutropenic patients. Increasing data suggest that the pathophysiology of neutropenic fever and neutropenic sepsis is substantially different from non-neutropenic fever and sepsis. Additional research is needed to both further elucidate the pathogenesis of neutropenic fever and to develop additional effective antimicrobials. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121977/ doi: 10.1007/978-3-319-74588-6_118 id: cord-021917-z9wpjr0d author: Stephens, R. Scott title: Bioterrorism and the Intensive Care Unit date: 2009-05-15 words: 8255.0 sentences: 444.0 pages: flesch: 44.0 cache: ./cache/cord-021917-z9wpjr0d.txt txt: ./txt/cord-021917-z9wpjr0d.txt summary: • Health care workers, accustomed to putting the welfare of patients ahead of their own in emergency situations, must be prepared for the proper use of personal protective equipment and trained in specific plans for the response to an infective or bioterrorism event. Although intensivists working in developed countries generally have little experience treating specific illnesses caused by serious bioweapon pathogens, these diseases result in clinical conditions that commonly require treatment in intensive care units (ICUs) (e.g., severe sepsis and septic shock, hypoxemic respiratory failure, and ventilatory failure). An optimal medical response to a bioweapon attack will require all or most of the following: early diagnosis, rapid case finding, large-scale distribution of countermeasures for postexposure prophylaxis or early treatment, immediate isolation of contagious victims, and enhanced capacity for providing medical care to seriously and critically ill victims. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152203/ doi: 10.1016/b978-0-323-02844-8.50069-x id: cord-317932-5sqj2klm author: Stevens, Jacob S. title: Dashboards to facilitate nephrology disaster planning in the COVID-19 era date: 2020-07-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2468024920313565?v=s5 doi: 10.1016/j.ekir.2020.06.033 id: cord-016521-ouwwkxox author: Stevens, Jennifer P. title: Ventilator-Associated Pneumonia and Other Complications date: 2016-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Ventilator-associated pneumonia occurs in patients who have been intubated for two to three days with significant exposure to hospital-acquired organisms. Treatment should be initiated rapidly and cover P. aeruginosa, Escheriochia coli, Klebsiella pneumonia, and Acinetobacter species as well as methicillin-resistant S. aureus. Within 72 h or with the availability of culture results, antibiotics should be narrowed. Active research is on-going to identify patients at risk for ventilator-associated complications and to minimize the likelihood of infection in these patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120823/ doi: 10.1007/978-3-319-43341-7_29 id: cord-338600-wpfcxnyu author: Stewart, Cameron title: Mental Capacity Assessments for COVID-19 Patients: Emergency Admissions and the CARD Approach date: 2020-11-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The doctrine of consent (or informed consent, as it is called in North America) is built upon presumptions of mental capacity. Those presumptions must be tested according to legal rules that may be difficult to apply to COVID-19 patients during emergency presentations. We examine the principles of mental capacity and make recommendations on how to assess the capacity of COVID-19 patients to consent to emergency medical treatment. We term this the CARD approach (Comprehend, Appreciate, Reason, and Decide). url: https://doi.org/10.1007/s11673-020-10055-2 doi: 10.1007/s11673-020-10055-2 id: cord-283826-lgyc3sro author: Stiehm, E. Richard title: Therapeutic Use of Immunoglobulins date: 2010-11-05 words: 9752.0 sentences: 562.0 pages: flesch: 37.0 cache: ./cache/cord-283826-lgyc3sro.txt txt: ./txt/cord-283826-lgyc3sro.txt summary: medical science and thereby placed in the hands of the physician a victorious weapon against illness and death.'' '' Since then antibodies in multiple forms (animal and human serums, immune globulins and monoclonal antibodies) have been developed, primarily for prevention of infectious diseases, and less commonly for their treatment. Thus regular use of IVIG in antibody-deficient patients in doses of 400 to 600 mg/kg every 3 to 4 weeks or an equivalent amount given subcutaneously decreases the frequency and severity of otitis and other respiratory tract infections [27, 28] . High-dose IVIG (sufficient to increase the serum IgG levels to 1000 mg/mL) has been used successfully in immunodeficient patients with enteroviral encephalomyelitis [80] [81] [82] [83] . Because IgG represents the major defense of humoral immunity against infection, these patients also require immunoglobulin replacement therapy. Individualizing the dose of intravenous immune serum globulin for therapy of patients with primary humoral immunodeficiency abstract: nan url: https://www.sciencedirect.com/science/article/pii/S006531011000006X doi: 10.1016/j.yapd.2010.08.005 id: cord-330573-rr2r8245 author: Stockmann, Helena title: CytoResc – “CytoSorb” Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: Approximately 8 - 10 % of COVID-19 patients present with a serious clinical course and need for hospitalization, 8% of hospitalized patients need ICU-treatment. Currently, no causal therapy is available and treatment is purely supportive. The main reason for death in critically ill patients is acute respiratory failure. However, in a number of patients a severe hyperinflammatory response with excessively elevated proinflammatory cytokines causes vasoplegic shock resistant to vasopressor therapy. A new polystyrene-based hemoadsorber (CytoSorb®, Cytosorbents Inc., New Jersey, USA) has been shown to adsorb effectively cytokines and other middle molecular weight toxins this way reducing their blood concentrations. This has been routinely used in clinical practice in the EU for other conditions where a cytokine storm occurs and an observational study has just been completed on COVID-19 patients. We hypothesized that the extracorporeal elimination of cytokines in critically ill COVID-19 patients with suspected hyperinflammation and shock may stabilize hemodynamics and improve outcome. The primary endpoint is time until resolution of vasoplegic shock, which is a well implemented, clinically relevant endpoint in critical care studies. TRIAL DESIGN: Phase IIb, multicenter, prospective, open-label, randomized, 1:1 parallel group pilot study comparing the additional use of “CytoSorb” to standard of care without “CytoSorb”. PARTICIPANTS: Patients are recruited from the Intensive Care Units (ICUs) of 7 participating centers in Germany (approximately 10 ICUs). All patients aged 18- 80 with positive polymerase chain reaction (PCR) test for SARS-CoV-2, a C-reactive protein (CRP) ≥ 100 mg/l, a Procalcitonin (PCT) < 2 ng/l, and suspected cytokine storm defined via a vasoplegic shock (Norepinephrine > 0.2 μg/min/kg to achieve a Mean Arterial Pressure ≥ 65mmHg). Patients are included irrespective of indication for renal replacement therapy. Suspected or proven bacterial cause for vasoplegic shock is a contraindication. INTERVENTION AND COMPARATOR: Within 24 hours after meeting the inclusion criteria patients will be randomized to receive either standard of care or standard of care and additional “CytoSorb” therapy via a shaldon catheter for 3-7 days. Filter exchange is done every 24 hours. If patients receive antibiotics, an additional dose of antibiotics is administered after each change of “CytoSorb” filter in order to prevent underdosing due to “CytoSorb” treatment. MAIN OUTCOMES: Primary outcome is time to resolution of vasoplegic shock (defined as no need for vasopressors for at least 8 hours in order to sustain a MAP ≥ 65mmHg) in days. Secondary outcomes are 7 day mortality after fulfilling the inclusion criteria, mortality until hospital discharge, Interleukin-6 (IL-6) measurement on day 1 and 3, need for mechanical ventilation, duration of mechanical ventilation, duration of ICU-stay, catecholamine dose on day 1/2/3 after start of “CytoSorb” and acute kidney injury. RANDOMIZATION: An electronic randomization will be performed using the study software secuTrial® administered by the Clinical Study Center (CSC) of the Charité – Universitätsmedizin Berlin, Germany. Randomization is done in blocks by 4 stratified by including center. BLINDING (MASKING): The trial will be non-blinded for the clinicians and patients. The statistician will receive a blinded data set, so that all analyses will be conducted blinded. NUMBERS TO BE RANDOMIZED (SAMPLE SIZE): As this is a pilot study with the goal to examine the feasibility of the study design as well as the intervention effect, no formal sample size calculation was conducted. A total number of approximately 80-100 patients is planned (40-50 patients per group). Safety assessment is done after the inclusion of each 10 patients per randomization group. TRIAL STATUS: Please see the study protocol version from April 24 2020. Recruitment of patients is still pending. TRIAL REGISTRATION: The study was registered on April 27 2020 in the German Registry of Clinical Trials (DRKS) under the number DRKS00021447. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://doi.org/10.1186/s13063-020-04501-0 doi: 10.1186/s13063-020-04501-0 id: cord-294557-4h0sybiy author: Stogiannos, N. title: Coronavirus disease 2019 (COVID-19) in the radiology department: What radiographers need to know date: 2020-06-04 words: 6725.0 sentences: 377.0 pages: flesch: 50.0 cache: ./cache/cord-294557-4h0sybiy.txt txt: ./txt/cord-294557-4h0sybiy.txt summary: Objectives include to: i) outline pathophysiology and basic epidemiology useful for radiographers, ii) discuss the role of medical imaging in the diagnosis of Covid-19, iii) summarise national and international guidelines of imaging Covid-19, iv) present main clinical and imaging findings and v) summarise current safety recommendations for medical imaging practice. CXR imaging of suspected or confirmed Covid-19 cases should be performed with portable equipment within specifically designated isolated rooms for eliminating the risks of cross-infection within the Radiology department. After the outbreak of the Covid-19 pandemic, many professional bodies and learned societies have been quick to issue official guidelines on how medical imaging should optimally be performed for early diagnosis and related management of these patients, but also how staff should be protected from cross-infection. Chest radiographic and CT findings of the 2019 novel Coronavirus disease (COVID-19): analysis of nine patients treated in Korea Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis abstract: OBJECTIVES: The aim is to review current literature related to the diagnosis, management, and follow-up of suspected and confirmed Covid-19 cases. KEY FINDINGS: Medical Imaging plays an important auxiliary role in the diagnosis of Covid-19 patients, mainly those most seriously affected. Practice differs widely among different countries, mainly due to the variability of access to resources (viral testing and imaging equipment, specialised staff, protective equipment). It has been now well-documented that chest radiographs should be the first-line imaging tool and chest CT should only be reserved for critically ill patients, or when chest radiograph and clinical presentation may be inconclusive. CONCLUSION: As radiographers work on the frontline, they should be aware of the potential risks associated with Covid-19 and engage in optimal strategies to reduce these. Their role in vetting, conducting and often reporting the imaging examinations is vital as well as their contribution in patient safety and care. Medical Imaging should be limited to critically ill patients, and where it may have an impact on the patient management plan. IMPLICATIONS FOR PRACTICE: At the time of publication, this review offers the most up-to-date recommendations for clinical practitioners in radiology departments, including radiographers. Radiography practice has to significantly adjust to these new requirements to support optimal and safe imaging practices for the diagnosis of Covid-19. The adoption of low dose CT, rigorous infection control protocols and optimal use of personal protective equipment may reduce the potential risks of radiation exposure and infection, respectively, within Radiology departments. url: https://www.sciencedirect.com/science/article/pii/S1078817420300845 doi: 10.1016/j.radi.2020.05.012 id: cord-295371-ccqne6nu author: Stoj, Victoria J. title: Dermatology residents and the care of patients with coronavirus disease 2019 (COVID-19) date: 2020-04-04 words: 610.0 sentences: 49.0 pages: flesch: 63.0 cache: ./cache/cord-295371-ccqne6nu.txt txt: ./txt/cord-295371-ccqne6nu.txt summary: title: Dermatology residents and the care of patients with coronavirus disease 2019 (COVID-19) Additionally, there is an American Academy of Dermatology Code of Medical Ethics that states, ''''It is .unethical for a dermatologist .to refuse the management of a patient because of medical risk, real or imagined (page 18, section 1C).'''' 4 Subsequently, in the current pandemic, it is a dermatologist''s duty to treat patients in the clinic, in the hospital, in the emergency room, and in the intensive care unit if called upon. The current COVID-19 pandemic is a public health crisis that requires physicians, of all specialties, to step up and help. The bottom line is that to fulfill your obligation as a professional in the house of medicine, ensure medical care is delivered to those in need (distributive justice), help patients, and do no harm (beneficence and nonmaleficence,) and for your own dignity, do not call a lawyer! abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0190962220305090 doi: 10.1016/j.jaad.2020.03.086 id: cord-006750-cg2i2bae author: Stoots, Sarah Abramson title: Clinical Insights into Diffuse Alveolar Hemorrhage in Antiphospholipid Syndrome date: 2019-09-06 words: 5220.0 sentences: 303.0 pages: flesch: 31.0 cache: ./cache/cord-006750-cg2i2bae.txt txt: ./txt/cord-006750-cg2i2bae.txt summary: PURPOSE OF REVIEW: Diffuse alveolar hemorrhage (DAH) is a rare but devastating manifestation of antiphospholipid syndrome (APS) patients with or without other systemic autoimmune diseases. In our experience, two different presentations of aPL-positive patients with DAH exist: (a) acute-with moderate to severe pulmonary hemorrhage (with varying degrees of respiratory failure) requiring hospitalization and (b) chronic-with mild hemoptysis, dyspnea, and/or positive imaging findings, usually seen as an outpatient. Antiphospholipid antibodies as a cause of pulmonary capillaritis and diffuse alveolar hemorrhage: a case series and literature review Difficulties in the treatment of recurring diffuse alveolar hemorrhage accompanying primary antiphospholipid syndrome: a case report and literature review Pulmonary capillaritis, alveolar hemorrhage, and recurrent microvascular thrombosis in primary antiphospholipid syndrome Rituximab induces resolution of recurrent diffuse alveolar hemorrhage in a patient with primary antiphospholipid antibody syndrome Primary antiphospholipid syndrome associated with diffuse alveolar hemorrhage and pulmonary thromboembolism abstract: PURPOSE OF REVIEW: Diffuse alveolar hemorrhage (DAH) is a rare but devastating manifestation of antiphospholipid syndrome (APS) patients with or without other systemic autoimmune diseases. Data regarding diagnosis and treatment are limited to case series. We review diagnostic and therapeutic strategies employed in APS patients with DAH and discuss our experience in managing these complex patients. RECENT FINDINGS: Pulmonary capillaritis likely contributes to the pathogenesis, however is only observed in half of the biopsies. Corticosteroids induce remission in the majority of patients, however almost half recur and require a steroid-sparing immunosuppressive to maintain remission. Cyclophosphamide- or rituximab-based regimens achieve the highest remission rates (50%); other strategies include intravenous immunoglobulin, plasmapheresis, mycophenolate mofetil, and/or azathioprine. SUMMARY: Given the rarity of DAH in APS, treatment is guided by interdisciplinary experience. Why certain patients achieve full remission with corticosteroids while others require immunosuppressive agents is unknown; future research should focus on the pathophysiology and optimal management. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102334/ doi: 10.1007/s11926-019-0852-7 id: cord-295144-tyyc81uc author: Stradner, Martin H. title: Rheumatic Musculoskeletal Diseases and COVID-19 A Review of the First 6 Months of the Pandemic date: 2020-10-09 words: 9901.0 sentences: 442.0 pages: flesch: 39.0 cache: ./cache/cord-295144-tyyc81uc.txt txt: ./txt/cord-295144-tyyc81uc.txt summary: In this review, we summarize the published cases of COVID-19 infections in RMD patients, including patients with inflammatory arthritis and connective tissue diseases as well as anti-phospholipid syndrome and Kawasaki syndrome. It also reviews the general risk of viral infections in patients with RMD, the impact of disease modifying anti-rheumatic drugs (DMARDs) on the outcome of infections, and gives a comparison between present and previous coronavirus pandemics. This argues against a protective role of HCQ (in the usually administered dose for RMD patients) in SARS-CoV-2 infection, which is also supported by pharmacological in vitro data describing a much higher level needed for effective viral inhibition (61) . In conclusion, data published in the first 6 months do not consistently describe a higher risk for infection with SARS-CoV-2 or a more severe course of COVID-19 in patients with either inflammatory arthritis or connective tissue diseases. abstract: In December 2019, a cluster of severe pneumonia was observed in China, with the subsequent discovery of a new beta-coronavirus (SARS-CoV-2) as the causative agent. The elicited disease COVID-19 is characterized by fever, dry cough, myalgia, or fatigue and has a favorable outcome in the majority of cases. However, in some patients COVID-19 leads to severe pneumonia and sepsis with subsequent respiratory failure and gastrointestinal, hematological, neurological, and cardiovascular complications. A higher risk of infection is intrinsic to active rheumatic and musculoskeletal diseases (RMD) and the use of biological disease modifying anti-rheumatic drugs (DMARDs). With an increasing number of reports on COVID-19 in RMD patients, we are beginning to appraise their risks. In this review, we summarize the published cases of COVID-19 infections in RMD patients, including patients with inflammatory arthritis and connective tissue diseases as well as anti-phospholipid syndrome and Kawasaki syndrome. Overall, patients with inflammatory arthritis do not seem to be at a higher risk for infection or a severe course of COVID-19. Risk for critical COVID-19 in patients with systemic inflammatory diseases such as SLE or vasculitis might be increased, but this needs further confirmation. Furthermore, we summarize the data on DMARDs used to fight SARS-CoV-2 infection and hyperinflammation. url: https://www.ncbi.nlm.nih.gov/pubmed/33154972/ doi: 10.3389/fmed.2020.562142 id: cord-338729-v2suoj3c author: Streicher, Caroline title: Could Tocilizumab be an Attractive Therapeutic Option for Elderly Patients with Severe COVID-19? A Case Report date: 2020-09-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32951190/ doi: 10.1007/s40261-020-00969-5 id: cord-016871-1mlamf20 author: Streiff, Agathe title: Hemorrhage and Transfusions in the Surgical Patient date: 2012-10-30 words: 9056.0 sentences: 429.0 pages: flesch: 46.0 cache: ./cache/cord-016871-1mlamf20.txt txt: ./txt/cord-016871-1mlamf20.txt summary: In acutely bleeding patients, massive transfusion protocols are often activated in order to ef fi caciously restore blood volume and hemostasis and thawed plasma is critical to their success [ 5, 6 ] . DCR is also supported by fi ndings from the US Army''s Institute of Surgical Research, which demonstrated improvement in outcomes in severely bleeding patients who were transfused in ratios of products similar to whole blood. However, some groups have shown that those patients receiving less than massive transfusion levels may still bene fi t from higher plasma to red blood cell ratios [ 20 ] . Silver et al.''s randomized, double-blind, placebo-controlled trial investigated the role of epoetin alfa, a recombinant erythropoietin, in reducing the RBC transfusion requirement of long-term acute care patients, thereby reducing risks associated with transfusions [ 29 ] . abstract: Hemorrhage is the leading cause of intraoperative deaths. Many cardiovascular and hepatobiliary procedures result in massive hemorrhage and postpartum hemorrhage events in labor and delivery place the patient at a high risk for mortality. Gastrointestinal bleeding from diverticulosis, varices, and ulcer disease can result in significant blood loss requiring massive transfusion and resuscitation from hemorrhagic shock. Timely and effective transfusion of blood products is of critical in these scenarios. The frequency in which blood component products are transfused in surgical patients begs for a greater understanding of them. The aim of this chapter is to provide clinicians with a discussion of the current literature on the various blood component products, their indications, and unique hemostatic conditions in the surgical patient. While the majority of data concerning optimal management of acquired coagulopathy and hemorrhagic shock resuscitation is based on trauma patients, many of the principles can and should be applied to the surgical patient (or likely any patient) with profound hemorrhage. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121296/ doi: 10.1007/978-1-4614-6123-4_12 id: cord-261670-rd9uq6tc author: Stringer, Kathleen A. title: COVID‐19: The Uninvited Guest in the Intensive Care Unit — Implications for Pharmacotherapy date: 2020-05-04 words: 2882.0 sentences: 154.0 pages: flesch: 42.0 cache: ./cache/cord-261670-rd9uq6tc.txt txt: ./txt/cord-261670-rd9uq6tc.txt summary: Fever, cough, and dyspnea are the most common signs of COVID-19 5 ; it is a respiratory tract infection with pneumonia being the hallmark of more severe illness and the acute respiratory distress syndrome (ARDS), a serious complication and manifestation of its most critical form (Table 1) . 13 Although these findings have not been replicated in human studies or in the setting of COVID-19, such potential upregulation of ACE2 by ACE inhibitors or ARBs has resulted in speculation that these medications might worsen infection or predispose patients to myocardial injury. In a preclinical model of severe acute respiratory syndrome (SARS Co-V), treatment with losartan improved angiotensin signaling, ARDS, and survival, 14 and severe COVID infections are associated with low (not high) expression of ACE2. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study abstract: As the number of cases of COVID-19 (SARS-CoV-2) rise in the United States (US), the number of severe cases (those requiring ICU admission) rise with it. Initially, the estimate for severe cases was approximated at 5% based on experience from China.1, 2 However, the World Health Organization's (WHO) estimate from China for severe and critical cases is near 20% (Table).3 The primary clinical feature of COVID-19 is pneumonia, the severity of which directs the clinical course; it has been estimated that, of patients admitted to the ICU, up to half may require either invasive or non-invasive ventilatory support.4 This has created an unprecedented situation for emergency and critical care medicine. url: https://www.ncbi.nlm.nih.gov/pubmed/32267979/ doi: 10.1002/phar.2394 id: cord-326883-j7pbe50g author: Stöbe, Stephan title: Echocardiographic characteristics of patients with SARS-CoV-2 infection date: 2020-08-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Myocardial involvement induced by SARS-CoV-2 infection might be important for long-term prognosis. The aim of this observational study was to characterize the myocardial effects during SARS-CoV-2 infections by echocardiography. RESULTS AND METHODS: An extended echocardiographic image acquisition protocol was performed in 18 patients with SARS-CoV-2 infection assessing LV longitudinal, radial, and circumferential deformation including rotation, twist, and untwisting. Furthermore, LV deformation was analyzed in an age-matched control group of healthy individuals (n = 20). The most prevalent finding was a reduced longitudinal strain observed predominantly in more than one basal LV segment (n = 10/14 patients, 71%). This pattern reminded of a “reverse tako-tsubo” morphology that is not typical for other viral myocarditis. Additional findings included a biphasic pattern with maximum post-systolic or negative regional radial strain predominantly basal (n = 5/14 patients, 36%); the absence or dispersion of basal LV rotation (n = 6/14 patients, 43%); a reduced or positive regional circumferential strain in more than one segment (n = 7/14 patients, 50%); a net rotation showing late post-systolic twist or biphasic pattern (n = 8/14 patients, 57%); a net rotation showing polyphasic pattern and/or higher maximum net values during diastole (n = 8/14 patients, 57%). CONCLUSION: Myocardial involvement due to SARS-CoV-2-infection was highly prevalent in the present cohort—even in patients with mild symptoms. It appears to be characterized by specific speckle tracking deformation abnormalities in the basal LV segments. These data set the stage to prospectively test whether these parameters are helpful for risk stratification and for the long-term follow-up of these patients. url: https://doi.org/10.1007/s00392-020-01727-5 doi: 10.1007/s00392-020-01727-5 id: cord-035090-gnfeyddv author: Su, Qi title: Adults with severe Japanese encephalitis: a retrospective analysis of 9 cases in Linyi, China date: 2020-11-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: Japanese encephalitis (JE) is a critical problem of public health worldwide; however, there is limited data about the clinical features and indicators of outcome in adults with severe Japanese encephalitis. METHODS: The clinical manifestations and laboratory study on brain neuroimaging of patients with severe JE were statistically analyzed retrospectively. All patients were followed up for 6 months after discharge. The patients were grouped into good outcome and poor outcome according to the results of the follow-up. RESULTS: This retrospective study consists of 9 adults with severe JE, including 5 cases with poor outcome, defined as the modified Rankin Scale (mRS) scores of greater than or equal to 4 points, and remained ventilator dependent. Typical clinical manifestations of JE include fever (100%), altered consciousness (100%), headache (66.7%), flaccid weakness (66.7%), and status epilepticus (44.4%). Serological examination revealed that a higher percentage of neutrophils and a lower percentage of lymphocytes at admission may be associated with a poor outcome. Abnormal neuroimaging of the thalamus (85.7%), hippocampal (71.4%), midbrain (28.6%), and basal ganglia (14.3%) was found. 42.9% of patients left severe irreversible disability, and the most prominent were mental symptoms (71.4%) and memory or understanding disorder (57.1%). CONCLUSION: Our data suggest that respiratory failure is one of the important causes of early death. Serologic examination, coma, and status epilepticus may indicate a poor outcome for severe JE. Additionally, the hippocampus is the second most common lesion in the adults with severe JE. A large-scale clinical trial is required to further confirm these conclusions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-020-04867-8. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652048/ doi: 10.1007/s10072-020-04867-8 id: cord-316616-j82q99in author: Su, Yen-Bo title: Cardiovascular manifestation and treatment in COVID-19 date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus disease 2019 (COVID-19), with first presentation of atypical pneumonia, has spread rapidly from Wuhan, China, on December 12, 2019 to over 200 countries, caused 2 310 572 infected individuals and 158 691 mortalities, updated on April 19, 2020. Many studies have published timely to help global healthcare workers to understand and control the disease. Vulnerable patients with risk factors such as elderly, cardiovascular diseases (eg, hypertension, coronary disease, or cardiomyopathy), diabetes, and chronic kidney disease have worse outcomes after COVID-19 infection. COVID-19 could directly cause cardiovascular injuries such as pericarditis, myocarditis, myocardial infarction, heart failure, arrhythmias, or thromboembolic events, which urge cardiologists to be involved in the frontline to practice. Here, we provide a review of COVID-19 on cardiovascular system to assist clinical cardiologists to better understand the disease and being capable of providing comprehensive medical support. url: https://doi.org/10.1097/jcma.0000000000000352 doi: 10.1097/jcma.0000000000000352 id: cord-339686-oybnk1j8 author: Suassuna, José Hermógenes Rocco title: Technical note and clinical instructions for Acute Kidney Injury (AKI) in patients with Covid-19: Brazilian Society of Nephrology and Brazilian Association of Intensive Care Medicine date: 2020-08-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We produced this document to bring pertinent information to the practice of nephrology, as regards to the renal involvement with COVID-19, the management of acute kidney injury cases, and practical guidance on the provision of dialysis support.As information on COVID-19 evolves at a pace never before seen in medical science, these recommendations, although based on recent scientific evidence, refer to the present moment. The guidelines may be updated when published data and other relevant information become available. url: https://doi.org/10.1590/2175-8239-jbn-2020-s107 doi: 10.1590/2175-8239-jbn-2020-s107 id: cord-305650-su6furzi author: Sud, Karan title: Echocardiographic Findings in COVID-19 Patients with Significant Myocardial Injury date: 2020-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32595004/ doi: 10.1016/j.echo.2020.05.030 id: cord-331317-q01uos7a author: Suh, Gee Young title: Early Intervention Can Improve Clinical Outcome of Acute Interstitial Pneumonia date: 2015-12-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: STUDY OBJECTIVES: To report on our experience with acute interstitial pneumonia (AIP) in which patients underwent early diagnostic procedures and received mechanical ventilation with a “lung-protective” strategy and early institution of immunosuppressive therapy. DESIGN: A retrospective chart review. SETTING: A tertiary referral hospital. PARTICIPANTS: Ten patients with AIP who presented with idiopathic ARDS and showed diffuse alveolar damage on surgical lung biopsy specimens from July 1995 to March 2004. MEASUREMENTS AND RESULTS: The median age of patients was 65.5 years (age range, 38 to 73 years). Patients presented with a median duration of severe dyspnea of 9.5 days (range, 2 to 34 days) at the hospital visit. All patients required mechanical ventilation beginning at median time of hospital day 1 (range, hospital day 0 to 5), which continued for a median duration of 9.5 days (range, 4 to 98 days). Patients received ventilation in the pressure assist-control mode with a median tidal volume of 6.97 mL/kg (range, 6.05 to 8.86 mL/kg) and median positive end-expiratory pressure of 11 cm H(2)O (range, 8 to 16 cm H(2)O). An aggressive diagnostic workup for respiratory infection, including BAL at a median time of hospital day 2 (range, hospital day 1 to 5) was performed. High-dose steroid pulse therapy was initiated on median hospital day 3.5 (range, hospital day 1 to 8), while surgical lung biopsy was performed on median hospital day 4 (range, hospital day 2 to 7). Eight patients (80%) survived to hospital discharge. CONCLUSION: Earlier intervention, such as an aggressive diagnostic approach, mechanical ventilation with lung-protective strategy, and the early institution of immunosuppressive may improve clinical outcome in patients with AIP. url: https://www.ncbi.nlm.nih.gov/pubmed/16537878/ doi: 10.1378/chest.129.3.753 id: cord-002757-upwe0cpj author: Sullivan, Kathleen E. title: Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies date: 2017-08-07 words: 24212.0 sentences: 1364.0 pages: flesch: 40.0 cache: ./cache/cord-002757-upwe0cpj.txt txt: ./txt/cord-002757-upwe0cpj.txt summary: The first section addresses general considerations, the second section profiles specific infections organized according to mechanism of transmission, and the third section focuses on unique phenotypes and unique susceptibilities in patients with PIDDs. This review does not address most parasitic diseases. In developing countries where polio is still endemic and oral polio vaccine is essential for eradicating the disease, it is of utmost importance that all PIDD patients and family members should not receive live oral polio (OPV) because of the reported prolonged excretion of the virus for months and even years [24] . As for host factors, although severe and fatal cases have been described in healthy immunocompetent hosts [129, 130] , there is evidence to suggest that children under the age of 10 [130] and immunocompromised hosts either secondary to hematologic malignancies, immunosuppressant treatment for organ transplantation, or HIV infection are at a greater risk to develop more severe disease with higher case fatality rates [131, 132] . abstract: In today’s global economy and affordable vacation travel, it is increasingly important that visitors to another country and their physician be familiar with emerging infections, infections unique to a specific geographic region, and risks related to the process of travel. This is never more important than for patients with primary immunodeficiency disorders (PIDD). A recent review addressing common causes of fever in travelers provides important information for the general population Thwaites and Day (N Engl J Med 376:548-560, 2017). This review covers critical infectious and management concerns specifically related to travel for patients with PIDD. This review will discuss the context of the changing landscape of infections, highlight specific infections of concern, and profile distinct infection phenotypes in patients who are immune compromised. The organization of this review will address the environment driving emerging infections and several concerns unique to patients with PIDD. The first section addresses general considerations, the second section profiles specific infections organized according to mechanism of transmission, and the third section focuses on unique phenotypes and unique susceptibilities in patients with PIDDs. This review does not address most parasitic diseases. Reference tables provide easily accessible information on a broader range of infections than is described in the text. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693703/ doi: 10.1007/s10875-017-0426-2 id: cord-026991-75sbxnsc author: Sultan, Omar Muayad title: Pulmonary ct manifestations of COVID-19: changes within 2 weeks duration from presentation date: 2020-06-17 words: 2895.0 sentences: 156.0 pages: flesch: 55.0 cache: ./cache/cord-026991-75sbxnsc.txt txt: ./txt/cord-026991-75sbxnsc.txt summary: This retrospective study aims to determine and compare the pulmonary changes in Iraqi patients with COVID-19 disease across the first two weeks after onset of symptoms using computerized tomography (CT) scan. With the continuing COVID-19 pandemic and the increasing number of patients suspected or confirmed with the disease, the radiologists are facing more and more cases because of the paramount role of imaging, particularly chest CT scans in the workup algorithm. In the current study, we compared the pulmonary radiological features associated with COVID-19 infection between two groups of patients, who underwent chest CT scans after different durations from initial clinical presentations. In conclusion, there is a significant difference in the pulmonary manifestations associated with COVID-19 infection when CT scan conducted earlier or later after the clinical presentation, with alteration, on one hand in the proportion and combination of GGO (becoming less) and consolidation (getting more) and, on another hand, more diffuse and multilobar distribution at the second week. abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Chest computed tomography (CT) plays an essential role in the evaluation of COVID-19. This retrospective study aims to determine and compare the pulmonary changes in Iraqi patients with COVID-19 disease across the first two weeks after onset of symptoms using computerized tomography (CT) scan. Ninety-six patients with COVID-19 disease were enrolled in this study. Patients were divided into two groups according to the duration of symptoms (the first group has been scanned within the first week of presentation while the second group has been scanned in the second week). RESULTS: The CT findings in the first and second group were as follows: ground glass opacity (GGO) were 94.3% vs. 88.5%, consolidation were 25.7% vs. 34.6%, broncho vascular thickening were 18.6% vs. 7.7%, crazy paving appearance were 15.7% vs. 3.8%, tree-in-bud appearance were 4.3% vs. 10.7%, pulmonary nodules were 5.1% vs. 7.7%, and bronchiectasis were 5.5% vs. 7.7%. Pleural effusion and cavitation were seen only in the first group (2.9% and 1.4% respectively). The distribution of CT changes across the two groups were as follows: bilateral changes were 85.7% vs. 100%; central distribution were 11.4% vs. 11.5%; peripheral distribution were 64.3% vs. 42.3%, and diffuse (central and peripheral) distribution were 24.3% vs. 46.2% while multilobar distribution were 70% vs. 80.8%. CONCLUSION: The type, extent, and distributions of pulmonary manifestations associated with COVID-19 infection are significantly different between the two groups who have been scanned in different stages of the disease. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299137/ doi: 10.1186/s43055-020-00223-0 id: cord-354216-4khdcjed author: Sultan, Shahnaz title: AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19 date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Background Multiple gastrointestinal (GI) symptoms including diarrhea, nausea/vomiting, and abdominal pain, as well liver enzyme abnormalities have been variably reported in patients with COVID-19. The AGA) Institute Clinical Guideline Committee and Clinical Practice Updates Committee performed a systematic review and meta-analysis of international data on GI and liver manifestations of COVID-19. Methods We performed a systematic literature search to identify published and unpublished studies using OVID Medline and pre-print servers (medRxiv, LitCovid, and SSRN) up until April 5 2020; major journal sites were monitored for US publications until April 19 2020. We analyzed the prevalence of diarrhea, nausea, vomiting, and abdominal pain as well as LFT abnormalities using a fixed effect model and assessed the certainty of evidence using GRADE. Results We identified 118 studies and used a hierarchal study selection process to identify unique cohorts. We performed a meta-analysis of 47 studies including 10,890 unique patients. Pooled prevalence estimates of GI symptoms was diarrhea 7.7% (95% CI 7.2-8.2), nausea/vomiting 7.8% (95% CI 7.1-8.5), abdominal pain 2.7% (95% CI 2.0-3.4). Most studies reported on hospitalized patients. The pooled prevalence of elevated liver abnormalities was: AST 15.0% (13.6 to 16.5) and ALT 15.0% (13.6 to 16.4). When analyzed comparing data from China to studies from countries other than China, diarrhea, nausea/vomiting, liver abnormalities were more prevalent outside of China with diarrhea reported in 18.3% (16.6 to 20.1). Isolated GI symptoms were rarely reported. We also summarized of the Gl and liver adverse effects of the most commonly utilized medications for COVID19 Conclusions GI symptoms are associated with COVID-19 in less than 10% of patients. In studies outside of China, estimates are higher. Further studies are needed with standardized GI symptoms questionnaires and LFT checks on admission to better quantify and qualify the association of these symptoms with COVID-19. Based on findings from our meta-anlaysis, we make several Best Practice Statements for the consultative management of COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32407808/ doi: 10.1053/j.gastro.2020.05.001 id: cord-270740-3su8pc3f author: Sultan, Sherif title: COVID-19 Cytokine Storm and Novel Truth date: 2020-05-22 words: 2381.0 sentences: 140.0 pages: flesch: 56.0 cache: ./cache/cord-270740-3su8pc3f.txt txt: ./txt/cord-270740-3su8pc3f.txt summary: A Chinese scientist(5) used a bio-informatics model to describe the hypothesis of COVID 19 as methemoglobin, where the COVID-19 virus structural protein sticks to heme -displaces oxygen -which alters the iron-free ion, leading to inflammation of alveolar macrophages, which culminate in a systemic response ending in a cytokine storm . What we must focus on is that COVID19 attacks RBCs. Patients have frequently been found COVID-19, SARS2 is not ''pneumonia'' nor ARDS Through the current experience across the world, invasive ventilation is becoming the last resort, as emergency intubation from the Chinese, Italian and American experience evidences higher mortality, not to mention complications from tracheal scarring and stiff lung during the duration of intubation. The lung damage seen on CT scans is due to the oxidative stress released from the hemolysed red blood cells, which in turn overwhelm the natural defenses against pulmonary oxidative stress and cause a cytokine storm. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32593830/ doi: 10.1016/j.mehy.2020.109875 id: cord-308979-qhlvd2mt author: Sumino, Kaharu C. title: Detection of Severe Human Metapneumovirus Infection by Real-Time Polymerase Chain Reaction and Histopathological Assessment date: 2005-09-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BackgroundInfections with common respiratory tract viruses can cause high mortality, especially in immunocompromised hosts, but the impact of human metapneumovirus (hMPV) in this setting was previously unknown MethodsWe evaluated consecutive bronchoalveolar lavage and bronchial wash fluid samples from 688 patients—72% were immunocompromised and were predominantly lung transplant recipients—for hMPV by use of quantitative real-time polymerase chain reaction (PCR), and positive results were correlated with clinical outcome and results of viral cultures, in situ hybridization, and lung histopathological assessment ResultsSix cases of hMPV infection were identified, and they had a similar frequency and occurred in a similar age range as other paramyxoviral infections. Four of 6 infections occurred in immunocompromised patients. Infection was confirmed by in situ hybridization for the viral nucleocapsid gene. Histopathological assessment of lung tissue samples showed acute and organizing injury, and smudge cell formation was distinct from findings in infections with other paramyxoviruses. Each patient with high titers of hMPV exhibited a complicated clinical course requiring prolonged hospitalization ConclusionsOur results provide in situ evidence of hMPV infection in humans and suggest that hMPV is a cause of clinically severe lower respiratory tract infection that can be detected during bronchoscopy by use of real-time PCR and routine histopathological assessment url: https://www.ncbi.nlm.nih.gov/pubmed/16107959/ doi: 10.1086/432728 id: cord-327764-4nlg26p5 author: Sun, Da-wei title: The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: a sentinel? date: 2020-05-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The underlying changes of peripheral blood inflammatory cells (PBICs) in COVID-19 patients are little known. Moreover, the risk factors for the underlying changes of PBICs and their predicting role in severe COVID-19 patients remain uncertain. MATERIAL AND METHODS: This retrospective study including two cohorts: the main cohort enrolling 45 patients of severe type serving as study group, and the secondary cohort enrolling 12 patients of no-severe type serving as control group. The PBICs analysis was based on blood routine and lymphocyte subsets. The inflammatory cell levels were compared among patients according to clinical classifications, disease-associated phases, as well as one-month outcomes. RESULTS: Compared with patients of non-severe type, the patients of severe type suffered from significantly decreased counts of lymphocytes, eosinophils, basophils, but increased counts of neutrophils. These PBICs alterations got improved in recovery phase, but persisted or got worse in aggravated phase. Compared with patients in discharged group, the patients in un-discharged/died group suffered from decreased counts of total T lymphocytes, CD4+T lymphocytes, CD8+T lymphocytes, as well as NK cells at 2 weeks after treatment. Clinical classification-critically severe was the independently risk factor for lymphopenia (OR=7.701, 95%CI:1.265-46.893, P=0.027), eosinopenia (OR=5.595, 95%CI:1.008-31.054, P=0.049) and worse one-month outcome (OR=8.984; 95%CI:1.021-79.061, P=0.048). CONCLUSION: Lymphopenia and eosinopenia may serve as predictors of disease severity and disease progression in COVID-19 patients, and enhancing the cellular immunity may contribute to COVID-19 treatment. Thus, PBICs might become a sentinel of COVID-19, and it deserves attention during COVID-19 treatment. url: https://www.sciencedirect.com/science/article/pii/S0009898120302242?v=s5 doi: 10.1016/j.cca.2020.05.027 id: cord-352304-tt2q5mgs author: Sun, Dan title: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study date: 2020-03-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: An outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first detected in Wuhan, Hubei, China. People of all ages are susceptible to SARS-CoV-2 infection. No information on severe pediatric patients with COVID-19 has been reported. We aimed to describe the clinical features of severe pediatric patients with COVID-19. METHODS: We included eight severe or critically ill patients with COVID-19 who were treated at the Intensive Care Unit (ICU), Wuhan Children’s Hospital from January 24 to February 24. We collected information including demographic data, symptoms, imaging data, laboratory findings, treatments and clinical outcomes of the patients with severe COVID-19. RESULTS: The onset age of the eight patients ranged from 2 months to 15 years; six were boys. The most common symptoms were polypnea (8/8), followed by fever (6/8) and cough (6/8). Chest imaging showed multiple patch-like shadows in seven patients and ground-glass opacity in six. Laboratory findings revealed normal or increased whole blood counts (7/8), increased C-reactive protein, procalcitonin and lactate dehydrogenase (6/8), and abnormal liver function (4/8). Other findings included decreased CD16 + CD56 (4/8) and Th/Ts*(1/8), increased CD3 (2/8), CD4 (4/8) and CD8 (1/8), IL-6 (2/8), IL-10 (5/8) and IFN-γ (2/8). Treatment modalities were focused on symptomatic and respiratory support. Two critically ill patients underwent invasive mechanical ventilation. Up to February 24, 2020, three patients remained under treatment in ICU, the other five recovered and were discharged home. CONCLUSIONS: In this series of severe pediatric patients in Wuhan, polypnea was the most common symptom, followed by fever and cough. Common imaging changes included multiple patch-like shadows and ground-glass opacity; and a cytokine storm was found in these patients, which appeared more serious in critically ill patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32193831/ doi: 10.1007/s12519-020-00354-4 id: cord-325655-1fktmpbj author: Sun, Dan-Qin title: Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32454505/ doi: 10.1159/000508502 id: cord-271660-5sfkhg19 author: Sun, Hsin-Yun title: Impact of introducing fluorescent microscopy on hospital tuberculosis control: A before-after study at a high caseload medical center in Taiwan date: 2020-04-03 words: 3884.0 sentences: 192.0 pages: flesch: 40.0 cache: ./cache/cord-271660-5sfkhg19.txt txt: ./txt/cord-271660-5sfkhg19.txt summary: METHODS: We measured the impact of switch to fluorescent microscopy on the smear detection rate of culture-confirmed pulmonary TB, timing of respiratory isolation, and total non-isolated infectious person-days in hospital at a high-caseload medical center (approximately 400 TB cases annually) in Taipei. Hospitalized patients had typical presentations of pulmonary TB if they had: (a) a prolonged cough for >3 weeks; (b) clinical suspicion of pulmonary TB based on chest radiography, such as cavitary pulmonary lesions, upper lobe diseases, or miliary lesions; or (c) already received a confirmed diagnosis of pulmonary TB by a positive sputum culture of Mycobacterium tuberculosis, positive acid-fast stain (AFS), or positive TB PCR, before the hospitalization. Our previous survey on age/sex-standardised TB incidence ratio of HCWs (using general population as reference)---the excess TB risk that are attributable to nosocomial TB transmission---in Medical Center A showed a drop of this risk, from 3.11 in 2006 to 1.37 in 2012 [23] , and the decrease in time-to-isolation and total non-isolated infectious patient-days was in parallel in the present study. abstract: BACKGROUND: Undiagnosed tuberculosis (TB) patients hospitalized because of comorbidities constitute a challenge to TB control in hospitals. We aimed to assess the impact of introducing highly sensitive fluorescent microscopy for examining sputum smear to replace conventional microscopy under a high TB risk setting. METHODS: We measured the impact of switch to fluorescent microscopy on the smear detection rate of culture-confirmed pulmonary TB, timing of respiratory isolation, and total non-isolated infectious person-days in hospital at a high-caseload medical center (approximately 400 TB cases annually) in Taipei. Multivariable Cox regression was applied to adjust for effects of covariates. The effect attributable to the improved smear detection rate was determined using causal mediation analysis. RESULTS: After switch to fluorescence microscopy, median non-isolated infectious duration decreased from 12.5 days to 3 days (P<0.001). Compared with conventional microscopy, fluorescence microscopy increased sputum smear detection rate by two-fold (for all patients: from 22.8% to 48.1%, P<0.001; for patients with cavitary lung lesion: from 43% to 82%, P = 0.029) and was associated with a 2-fold higher likelihood of prompt respiratory isolation (odds ratio mediated by the increase in sputum smear detection rate: 1.8, 95% CI 1.3–2.5). Total non-isolated infectious patient-days in hospital decreased by 69% (from 4,778 patient-days per year to 1,502 patient-days per year). CONCLUSIONS: In a high TB caseload setting, highly sensitive rapid diagnostic tools could substantially improve timing of respiratory isolation and reduce the risk of nosocomial TB transmission. url: https://www.ncbi.nlm.nih.gov/pubmed/32243434/ doi: 10.1371/journal.pone.0230067 id: cord-275340-q8d7rvnj author: Sun, JingKang title: Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 date: 2020-06-21 words: 6629.0 sentences: 285.0 pages: flesch: 47.0 cache: ./cache/cord-275340-q8d7rvnj.txt txt: ./txt/cord-275340-q8d7rvnj.txt summary: CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells. ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; CQ, chloroquine; HCQ, hydroxychloroquine; CoVs, coronaviruses; MAPK, mitogen-activated protein kinase; MHC-II, major histocompatibility complex class II; TLR, toll-like receptor; cGAS, cyclic GMP-AMP synthase; IFN, interferon; IL, interleukin; TNF-α, tumor necrosis factor-α. The authors deemed that the anti-inflammatory effect of low-dose HCQ and the activity of inhibiting viral replication may have important significance in critically ill patients with COVID-19. abstract: Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A number of in vitro studies revealed inhibitory effects of CQ/HCQ on various coronaviruses, including SARS-CoV-2 although conflicting results exist. Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progression, with less serious adverse effects. However, recent studies indicated that the use of CQ/HCQ, alone or in combination with a macrolide, did not show any favorable effect on patients with COVID-19. Adverse effects, including prolonged QT interval after taking CQ/HCQ, may develop in COVID-19 patients. Therefore, current data are not sufficient enough to support the use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken about the application of CQ/HCQ in COVID-19 before conclusive findings are obtained by well-designed, multi-center, randomized, controlled studies. url: https://doi.org/10.1080/00325481.2020.1778982 doi: 10.1080/00325481.2020.1778982 id: cord-307217-0agij3z3 author: Sun, Qiulian title: Evolution of computed tomography manifestations of eleven patients with severe coronavirus disease 2019 (COVID‐19) pneumonia date: 2020-08-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Severe coronavirus disease 2019 (COVID‐19) pneumonia is associated with a high mortality. However, the evolution of computed tomography (CT) manifestations of severe COVID‐19 pneumonia remains unclear, more evidence regarding its evolution process is urgent needed. METHOD: The clinical, laboratory and imaging data of eleven patients with severe COVID‐19 pneumonia were collected to investigate the evolution process of severe COVID‐19 cases. RESULTS: The main initial CT manifestations of severe COVID‐19 pneumonia were multiple ground‐glass opacities and/or consolidation. Evolution of CT manifestations showed that acute exudative lesions of severe COVID‐19 pneumonia could be gradually resolved after active intervention. CONCLUSIONS: Most of patients with severe COVID‐19 pneumonia showed marked improvement of acute exudative lesions on chest imagings, and satisfactory prognosis of severe COVID‐19 pneumonia could be achieved after active treatment. url: https://doi.org/10.1111/ijcp.13654 doi: 10.1111/ijcp.13654 id: cord-346496-crhv0gnt author: Sun, Ying title: Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience date: 2020-04-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 has become one of the worst infectious disease outbreaks of recent times, with over 2.1 million cases and 120,000 deaths so far. Our study investigated the demographic, clinical, laboratory and imaging features of 63 patients with COVID-19 in Beijing. Patients were classified into four groups, mild, moderate, severe and critically ill. The mean age of our patients was 47 years of age (range 3–85) and there was a slight male predominance (58.7%). Thirty percent of our patients had severe or critically ill disease, but only 20% of severe and 33% of critically ill patients had been to Wuhan. Fever was the most common presentation (84.1%), but cough was present in only slightly over half of the patients. We found that lymphocyte and eosinophils count were significantly decreased in patients with severe disease (p = 0.001 and p = 0.000, respectively). Eosinopenia was a feature of higher levels of severity. Peripheral CD4(+), CD8(+) T lymphocytes, and B lymphocytes were significantly decreased in severe and critically ill patients, but there was only a non-statistically significant downward trend in NK cell numbers with severity. Of note is that liver function test including AST, ALT, GGT and LDH were elevated, and albumin was decreased. The inflammatory markers CRP, ESR and ferritin were elevated in patients with severe disease or worse. IL-6 levels were also higher, indicating that the presence of a hyperimmune inflammatory state portends higher morbidity and mortality. In a binary logistic regression model, C-reactive protein level (OR 1.073, [CI, 1.013–1.136]; p = 0.017), CD8 T lymphocyte counts (OR 0.989, [CI, 0.979–1.000]; p = 0.043), and D-dimer (OR 5.313, [CI, 0.325–86.816]; p = 0.241) were independent predictors of disease severity. url: https://www.ncbi.nlm.nih.gov/pubmed/32439209/ doi: 10.1016/j.jaut.2020.102473 id: cord-299254-kqpnwkg5 author: Sun, Yingcheng title: INSMA: An integrated system for multimodal data acquisition and analysis in the intensive care unit date: 2020-04-28 words: 4608.0 sentences: 210.0 pages: flesch: 41.0 cache: ./cache/cord-299254-kqpnwkg5.txt txt: ./txt/cord-299254-kqpnwkg5.txt summary: In this paper, we proposed a multimodal data acquisition and analysis system called INSMA, with the ability to acquire, store, process, and visualize multiple types of data from the Philips IntelliVue patient monitor. Enormous volumes of multimodal physiological data are generated including physiological waveform signals, patient monitoring alarm messages, and numerics and if acquired, synchronized and analyzed, this data can been effectively used to support clinical decision-making at the bedside [10, 18] . We have been working on building the Integrated Medical Environment (tIME) [10] to address this critical opportunity and in this paper, we discuss an integrated system (INSMA) that supports multimodal data acquisition, parsing, real-time data analysis and visualization in the ICU. Advances in informatics, whether through data acquisition, physiologic alarm detection, or signal analysis and visualization for decision support have the potential to markedly improve patient treatment in ICUs. Clinical monitors have the ability to collect and visualize important numerics or waveforms, but more work is needed to interface to the monitors and acquire and synchronize multimodal physiological data across a diverse set of clinical devices. abstract: Modern intensive care units (ICU) are equipped with a variety of different medical devices to monitor the physiological status of patients. These devices can generate large amounts of multimodal data daily that include physiological waveform signals (arterial blood pressure, electrocardiogram, respiration), patient alarm messages, numeric vitals data, etc. In order to provide opportunities for increasingly improved patient care, it is necessary to develop an effective data acquisition and analysis system that can assist clinicians and provide decision support at the patient bedside. Previous research has discussed various data collection methods, but a comprehensive solution for bedside data acquisition to analysis has not been achieved. In this paper, we proposed a multimodal data acquisition and analysis system called INSMA, with the ability to acquire, store, process, and visualize multiple types of data from the Philips IntelliVue patient monitor. We also discuss how the acquired data can be used for patient state tracking. INSMA is being tested in the ICU at University Hospitals Cleveland Medical Center. url: https://www.sciencedirect.com/science/article/pii/S1532046420300629?v=s5 doi: 10.1016/j.jbi.2020.103434 id: cord-304010-n4gxxl5i author: Sung, Ho Kyung title: Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January–May 2020 date: 2020-07-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The fatality rate of patients with coronavirus disease 2019 (COVID-19) varies among countries owing to demographics, patient comorbidities, surge capacity of healthcare systems, and the quality of medical care. We assessed the clinical outcomes of patients with COVID-19 during the first wave of the epidemic in Korea. METHODS: Using a modified World Health Organization clinical record form, we obtained clinical data for 3,060 patients with COVID-19 treated at 55 hospitals in Korea. Disease severity scores were defined as: 1) no limitation of daily activities; 2) limitation of daily activities but no need for supplemental oxygen; 3) supplemental oxygen via nasal cannula; 4) supplemental oxygen via facial mask; 5) non-invasive mechanical ventilation; 6) invasive mechanical ventilation; 7) multi-organ failure or extracorporeal membrane oxygenation therapy; and 8) death. Recovery was defined as a severity score of 1 or 2, or discharge and release from isolation. RESULTS: The median age of the patients was 43 years of age; 43.6% were male. The median time from illness onset to admission was 5 days. Of the patients with a disease severity score of 3–4 on admission, 65 (71.5%) of the 91 patients recovered, and 7 (7.7%) died due to illness by day 28. Of the patients with disease severity scores of 5–7, 7 (19.5%) of the 36 patients recovered, and 8 (22.2%) died due to illness by day 28. None of the 1,324 patients who were < 50 years of age died; in contrast, the fatality rate due to illness by day 28 was 0.5% (2/375), 0.9% (2/215), 5.8% (6/104), and 14.0% (7/50) for the patients aged 50–59, 60–69, 70–79, and ≥ 80 years of age, respectively. CONCLUSION: In Korea, almost all patients of < 50 years of age with COVID-19 recovered without supplemental oxygen. In patients of ≥ 50 years of age, the fatality rate increased with age, reaching 14% in patients of ≥ 80 years of age. url: https://www.ncbi.nlm.nih.gov/pubmed/32743995/ doi: 10.3346/jkms.2020.35.e280 id: cord-337906-qis8h3r3 author: Suresh Kumar, Vishnu Charan title: Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study date: 2020-09-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Since its discovery in Wuhan, China in December of 2019, the novel coronavirus has progressed to become one of the worst pandemics seen in the last 100 years. Recently, there has been an increased interest in the hepatic manifestations of coronavirus disease 19 (COVID-19). AIM: To describe the demographic and clinical characteristics of COVID-19 positive patients and study the association between transaminitis and all-cause mortality. METHODS: This is a descriptive retrospective cohort study of 130 consecutive patients with a positive COVID PCR test admitted between March 16, 2020 to May 14, 2020 at a tertiary care University-based medical center. The Wilcoxon-rank sum test and paired t-test were used for comparing non-parametric and parametric continuous variables respectively and a multivariable logistic regression models to study the association between transaminitis and mortality using SAS version 9.4 (SAS Institute, Cary, NC, United States). RESULTS: Out of the 130 patients, 73 (56%) patients were found to have transaminitis and 57 (44%) did not. When compared to patients without transaminitis, the transaminitis group was found to have a higher median body mass index (30.2 kg/m(2) vs 27.3 kg/m(2), P = 0.04). In the multivariate analysis those with transaminitis were found to have 3.4 times higher odds of dying as compared to those without transaminitis adjusting for gender, the Age-adjusted Charlson Comorbidity Index and admission to the intensive care unit (P = 0.03). CONCLUSION: Our study showed that transaminitis on admission was associated with severe clinical outcomes such as admission to the intensive care unit, need for mechanical ventilation, and mortality. url: https://doi.org/10.4254/wjh.v12.i9.619 doi: 10.4254/wjh.v12.i9.619 id: cord-259848-0thzmh7k author: Sutera, Diana title: Management of Pediatric Rheumatological Diseases During the Outbreak of COVID-19: Our Experience date: 2020-07-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32670527/ doi: 10.4084/mjhid.2020.049 id: cord-014540-27hnlu5v author: Sutthiruk, Nantanit title: Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC): Bangkok, Thailand. 12-15 February 2017 date: 2017-02-22 words: 24509.0 sentences: 1304.0 pages: flesch: 46.0 cache: ./cache/cord-014540-27hnlu5v.txt txt: ./txt/cord-014540-27hnlu5v.txt summary: A secondary questionnaire was sent to determine whether any cases showed a positive blood or cerebral spinal fluid culture for Extended Spectrum Beta-lactamase (ESBL) producing GNB, AmpC β-lactamases producing GNB, or carbapenem-resistant enterobacteriacae (CRE) between April 2012 and March 2015.The following data were collected; demographic data pertaining to both the care facilities and patients, clinical diagnosis, and outcomes. Utilization of diagnosis-procedure combination data for advancing the antimicrobial stewardship program Haruo Nakayama, Toshiko Ota, Naoko Shirane, Chikako Matuoka, Kentaro Kodama, Masanobu Ohtsuka Toho University Ohashi medical center, Tokyo, Japan Background Infection with antibiotic-resistant bacteria results in increased morbidity, mortality and economic burden. The purpose of this study was to test the effectively of the Infection Control Risk Assessment (ICRA) monitoring tool developed by the Infection Prevention and Control Unit (IPCU) of Asian Hospital and Medical Center with the aim to increase the compliance of construction workers to recommended infection prevention and control measures during construction, renovation and demolition in the hospital. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333188/ doi: 10.1186/s13756-017-0176-1 id: cord-253730-cdkzvfib author: Suzuki, Emily title: Assessment of the Need for Early Initiation of Rehabilitation Treatments in Patients with Coronavirus Disease 2019 date: 2020-08-13 words: 3452.0 sentences: 188.0 pages: flesch: 45.0 cache: ./cache/cord-253730-cdkzvfib.txt txt: ./txt/cord-253730-cdkzvfib.txt summary: OBJECTIVE: The aim of this study was to describe the clinical characteristics of coronavirus disease (COVID-19) patients, including risk factors for deep vein thrombosis and pulmonary embolism, and to evaluate the need for rehabilitation to prevent pulmonary embolism. The clinical characteristics and blood test results of patients with no history on admission of oral anticoagulant use were evaluated to assess the importance of inflammation and clotting function as risk factors for pulmonary embolism. 8) Because hypercoagulability and hyperinflammation have been reported in patients with COVID-19, we compared coagulability and inflammation by sex and the severity of COVID-19 to identify risk factors for PE that can be used to determine the necessity of early rehabilitation intervention to prevent PE. Considering the high risk of hospital-acquired infections and the worldwide shortage of medical resources, including not only PPE but also physicians, nurses, and rehabilitation therapists, it is understandable that the guidelines for physiotherapy do not recommend affirmative intervention for patients with moderate to severe COVID-19. abstract: OBJECTIVE: The aim of this study was to describe the clinical characteristics of coronavirus disease (COVID-19) patients, including risk factors for deep vein thrombosis and pulmonary embolism, and to evaluate the need for rehabilitation to prevent pulmonary embolism. METHODS: A retrospective medical record review was conducted of patients admitted to the study hospital with COVID-19 between April 2 and April 23, 2020. The clinical characteristics and blood test results of patients with no history on admission of oral anticoagulant use were evaluated to assess the importance of inflammation and clotting function as risk factors for pulmonary embolism. RESULTS: A total of 51 patients with COVID-19 were admitted during the study period. Their median age was 54.0 years (range: 41–63 years) and 38 of 51 (74.5%) were men. The most common comorbidities in men were diabetes (9/38, 23.7%) and hypertension (13/38, 34.2%). On admission, white blood cell counts were normal in both sexes, whereas C-reactive protein and hemostatic marker levels, except for the activated partial thromboplastin time, were significantly higher in men. Moreover, C-reactive protein and hemostatic marker levels were significantly higher in patients that required invasive ventilation. Two patients were diagnosed with acute pulmonary embolism, neither of whom required invasive ventilation. CONCLUSIONS: Hypercoagulability and hyperinflammation were observed in COVID-19 patients, especially in men with high oxygen demand. We recommend anticoagulant therapy and early rehabilitation intervention to prevent pulmonary embolism in COVID-19 patients. url: https://doi.org/10.2490/prm.20200018 doi: 10.2490/prm.20200018 id: cord-289690-af6lsj1g author: Svobodova, Tamara title: Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date: 2015-02-10 words: 3546.0 sentences: 211.0 pages: flesch: 39.0 cache: ./cache/cord-289690-af6lsj1g.txt txt: ./txt/cord-289690-af6lsj1g.txt summary: BACKGROUND: GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. CONCLUSION: We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic celland B-lymphopenia, irrespective of severity of the clinical phenotype. Defects of transcription factor GATA-2 have recently been identified in a few overlapping phenotypes associated with myeloid malignancies: dendritic cell, monocyte, B-and NK-cell deficiency; MonoMAC syndrome (monocytopenia with Mycobacterium avium complex infections); Emberger syndrome (early onset primary lymphedema, multiple warts, sensorineural deafness, dysmorphism); and familial MDS/AML with no additional known phenotype. We present an adolescent male with GATA-2 deficiency and early manifestation of diffuse parenchymal lung disease (DPLD) as well as an atypical course of Epstein-Barr virus (EBV) infection. abstract: BACKGROUND: GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. Patients often suffer from opportunistic respiratory infections; chronic pulmonary changes have been found in advanced disease. CASE PRESENTATION: We present a case of a 17-year-old previously healthy Caucasian male who was admitted to the hospital with fever, malaise, headache, cough and dyspnea. A chest X-ray revealed bilateral interstitial infiltrates and pneumonia was diagnosed. Despite prompt clinical improvement under antibiotic therapy, interstitial changes remained stable. A high resolution computer tomography showed severe diffuse parenchymal lung disease, while the patient’s pulmonary function tests were normal and he was asymptomatic. Lung tissue biopsy revealed chronic reparative and resorptive reaction with organizing vasculitis. At the time of the initial presentation to the hospital, serological signs of acute infection with Epstein-Barr virus (EBV) were present; EBV viremia with atypical serological response persisted during two-year follow up. No other infectious agents were found. Marked monocytopenia combined with B-cell lymphopenia led to a suspicion of GATA-2 deficiency. Diagnosis was confirmed by detection of the previously published heterozygous mutation in GATA2 (c.1081 C > T, p.R361C). The patient’s brother and father were both carriers of the same genetic defect. The brother had no clinically relevant ailments despite leukocyte changes similar to the index patient. The father suffered from spondylarthritis, and apart from B-cell lymphopenia, no other changes within the leukocyte pool were seen. CONCLUSION: We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic cell- and B-lymphopenia, irrespective of severity of the clinical phenotype. Genetic counseling and screening for GATA2 mutations within the patient’s family should be provided as the phenotype is highly variable and carriers without apparent immunodeficiency are still in danger of developing myeloid malignancy. A prompt recognition of this rare condition helps to direct clinical treatment strategies and follow-up procedures. url: https://www.ncbi.nlm.nih.gov/pubmed/25879889/ doi: 10.1186/s12890-015-0006-2 id: cord-327827-oliw4ee5 author: Sweid, Ahmad title: Letter: Thrombotic Neurovascular Disease in COVID-19 Patients date: 2020-06-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/neuros/nyaa254 doi: 10.1093/neuros/nyaa254 id: cord-309026-l2rh9bie author: Sweiss, Nadera J. title: When the game changes: Guidance to adjust sarcoidosis management during the COVID-19 pandemic date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.chest.2020.04.033 doi: 10.1016/j.chest.2020.04.033 id: cord-277189-fe8ego7f author: Szabados, Bernadett title: Clinical Characteristics and Outcome for Four SARS-CoV-2-infected Cancer Patients Treated with Immune Checkpoint Inhibitors date: 2020-05-26 words: 1698.0 sentences: 103.0 pages: flesch: 50.0 cache: ./cache/cord-277189-fe8ego7f.txt txt: ./txt/cord-277189-fe8ego7f.txt summary: Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with higher mortality among cancer patients, particularly in those on systemic therapy. During this period, 11 patients (15%) developed symptoms consistent with coronavirus disease 2019 (COVID-19) and four (5%) tested positive. These data suggest that the higher risk of COVID-19 death associated with systemic therapy in cancer may not apply to patients on ICIs. Assessment of COVID-19 severity in these patients can be complicated by the underlying cancer and its treatment. Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 ) is associated with higher mortality among cancer patients [1] . Current data on COVID-19 mortality among cancer patients group treatment modalities such as immune therapy and targeted therapy (n = 7) together, which is flawed [3] . The fever and cough resolved 5 d later, and the patient resumed his cancer treatment after completion of his self-isolation period. abstract: Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with higher mortality among cancer patients, particularly in those on systemic therapy. It is unclear whether this applies to patients receiving immune checkpoint inhibitors (ICIs). In this case series, 74 patients from a single institution with genitourinary (GU) cancer on ICI were followed up during a 12-wk period. During this period, 11 patients (15%) developed symptoms consistent with coronavirus disease 2019 (COVID-19) and four (5%) tested positive. Two patients had metastatic urothelial cancer (treated with atezolizumab) and two had metastatic renal cancer (treated with ipilimumab and nivolumab). All had additional risk factors associated with COVID-19 mortality and two received steroids within 1 mo of infection. Two patients developed symptoms requiring hospitalisation. All four are alive 32–45 d after their first symptoms and 28–38 d after testing positive. These patients all had multiple risk factors associated with severe COVID-19. These data suggest that the higher risk of COVID-19 death associated with systemic therapy in cancer may not apply to patients on ICIs. Assessment of COVID-19 severity in these patients can be complicated by the underlying cancer and its treatment. url: https://www.ncbi.nlm.nih.gov/pubmed/32534910/ doi: 10.1016/j.eururo.2020.05.024 id: cord-252687-7084pfqm author: Szelenberger, Rafal title: Ischemic Stroke among the Symptoms Caused by the COVID-19 Infection date: 2020-08-19 words: 7334.0 sentences: 378.0 pages: flesch: 37.0 cache: ./cache/cord-252687-7084pfqm.txt txt: ./txt/cord-252687-7084pfqm.txt summary: Many clinical studies have shown an association between SARS-CoV-2 infection and hypercoagulability diagnosed on the basis of abnormal coagulation parameters, including activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer and C-reactive protein level. In this review, the potential mechanism and the effect of the SARS-CoV-2 viral infection on the development of ischemic stroke in COVID-19 patients were carefully studied. study, in which most non-survivor COVID-19 patients'' (71.4%) blood tests showed prolonged prothrombin time and an increased D-dimer levels, which indicated the state after activation of the plasma coagulation system [14] . The accumulation of immune cells in the vascular wall in response to the viral infection, especially among patients with ischemic risk factors, induces endothelial dysfunction, migration and proliferation of cells, activation of coagulation cascade and production of fibrous plaques. abstract: The 2019 global pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern by the World Health Organization (WHO). The WHO recognized the spread of COVID-19 as a pandemic on 11 March 2020. Based on statistics from 10 August 2020, more than 20.2 million cases of COVID-19 have been reported resulting in more than 738,000 deaths. This completely new coronavirus has spread worldwide in a short period, causing economic crises and healthcare system failures worldwide. Initially, it was thought that the main health threat was associated with respiratory system failures, but since then, SARS-CoV-2 has been linked to a broad spectrum of symptoms indicating neurological manifestations, including ischemic stroke. Current knowledge about SARS-CoV-2 and its complications is very limited because of its rapidly evolving character. However, further research is undoubtedly necessary to understand the causes of neurological abnormalities, including acute cerebrovascular disease. The viral infection is inextricably associated with the activation of the immune system and the release of pro-inflammatory factors, that can stimulate the host organism to defend itself. However, the body’s immune response is a double-edged sword that on one hand, destroys the virus but also disrupts the homeostasis leading to serious complications, including thrombosis. Numerous studies have linked coagulopathies with COVID-19, however, there is great uncertainty regarding it functions on the molecular level. In this review, a detailed insight into the biological processes associated with ischemic stroke in COVID-19 patients and suggest a possible explanation for this phenomenon is provided. url: https://www.ncbi.nlm.nih.gov/pubmed/32825182/ doi: 10.3390/jcm9092688 id: cord-262454-bccrvapy author: Szente Fonseca, Silvia Nunes title: Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative Analysis date: 2020-10-31 words: 4700.0 sentences: 249.0 pages: flesch: 53.0 cache: ./cache/cord-262454-bccrvapy.txt txt: ./txt/cord-262454-bccrvapy.txt summary: With all that, we developed a protocol for early recognition and treatment of high-risk patients (in our population, age greater than 40 years because of generally poorer health standards, or with comorbidities) who would come to our outpatient network of emergency rooms with influenza-like symptoms: fever, cough, myalgia and headache, among others, and receive early treatment, provided to patients at the first doctor visit, using physician discretion from among HCQ, azithromycin, ivermectin, oseltamivir, zinc sulfate, nitazoxanide and prednisone (the last starting on day-6 of symptoms). On March 28, 2020, the FDA issued an emergency use authorization for remdesivir and HCQ for patients in both clinical trials and with severe hospitalized disease (31) . We found early outpatient use of HCQ and prednisone, both as individual prescriptions and used together, to lower the risk of hospitalization in symptomatic high-risk COVID-19 patients presenting for primary care at the emergency rooms of our large HMO in Brazil. abstract: BACKGROUND: For the past few months, HMOs have faced crowded emergency rooms and insufficient hospital and intensive-care-unit beds, all from the worst pandemic of this century, COVID-19. METHODS: In a large HMO in Brazil, our approach was to allow treating physicians to prescribe antiviral medications immediately at presentation, and prednisone starting on day-6 of symptoms to treat pulmonary inflammation. We implemented this COVID-19 protocol for outpatients and studied 717 consecutive SARS-CoV-2-positive patients age 40 years or older presenting at our emergency rooms. RESULTS: Use of hydroxychloroquine (HCQ), prednisone or both significantly reduced hospitalization risk by 50-60%. Ivermectin, azithromycin and oseltamivir did not substantially reduce risk further. Hospitalization risk was doubled for people with type-2 diabetes or obesity, increased by two-thirds for people with heart disease, and by 75% for each decade of age over age 40. Similar magnitudes of reduced risk with HCQ and prednisone use were seen for mortality risk, though were not significant because of only 11 deaths among the 717 patients. No cardiac arrhythmias requiring medication termination were observed for any of the medications. CONCLUSIONS: This work adds to the growing literature of studies that have found substantial benefit for use of HCQ combined with other agents in the early outpatient treatment of COVID-19, and adds the possibility of steroid use to enhance treatment efficacy. url: https://www.sciencedirect.com/science/article/pii/S1477893920304026?v=s5 doi: 10.1016/j.tmaid.2020.101906 id: cord-316370-t802kjpk author: Szperka, Christina L. title: Migraine Care in the Era of COVID‐19: Clinical Pearls and Plea to Insurers date: 2020-04-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To outline strategies for the treatment of migraine which do not require in‐person visits to clinic or the emergency department, and to describe ways that health insurance companies can remove barriers to quality care for migraine. BACKGROUND: COVID‐19 is a global pandemic causing widespread infections and death. To control the spread of infection we are called to observe “social distancing” and we have been asked to postpone any procedures which are not essential. Since procedural therapies are a mainstay of headache care, the inability to do procedures could negatively affect our patients with migraine. In this manuscript we review alternative therapies, with particular attention to those which may be contra‐indicated in the setting of COVID‐19 infection. DESIGN/RESULTS: The manuscript reviews the use of telemedicine visits and acute, bridge, and preventive therapies for migraine. We focus on evidence‐based treatment where possible, but also describe “real world” strategies which may be tried. In each section we call out areas where changes to rules from commercial health insurance companies would facilitate better migraine care. CONCLUSIONS: Our common goal as health care providers is to maximize the health and safety of our patients. Successful management of migraine with avoidance of in‐person clinic and emergency department visits further benefits the current urgent societal goal of maintaining social distance to contain the COVID‐19 pandemic. url: https://doi.org/10.1111/head.13810 doi: 10.1111/head.13810 id: cord-288051-wp8v2mc5 author: Sánchez-González, Álvaro title: What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date: 2020-09-01 words: 3616.0 sentences: 267.0 pages: flesch: 47.0 cache: ./cache/cord-288051-wp8v2mc5.txt txt: ./txt/cord-288051-wp8v2mc5.txt summary: Seven days after the clinical onset, the risk of transmission decreases in mildsymptomatic patients, but it may be extended over 24 days in severe cases [11•, 15] . The clinical spectrum of SARS-CoV-2 infection varies widely, including asymptomatic infection, mild upper respiratory tract illness, severe viral pneumonia with respiratory failure, and even death [9, 11•] (Fig. 1) . Corticosteroids are recommended in the treatment of septic shock, exacerbation of chronic obstructive respiratory disease and these COVID-19''s patients with respiratory deterioration and quick radiological progression associated with sings of cytokine storm (cytopenia, maintained fever, an increase of inflammatory reactants: D-dimer > 1000 ng/mL, ferritin > 1000 ng/mL, fibrinogen > 100 ng/mL, IL-6 > 40 pg/mL) [6, 23••] . Results from 237 patients, 158 assigned to remdesivir, showed no differences in time to clinical improvement, 28day mortality, oxygen support, hospitalization, or viral load. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Effective treatment of severe COVID-19 patients with tocilizumab abstract: PURPOSE OF REVIEW: The alarming number of confirmed COVID-19 cases put a strain on the healthcare systems, which had to reallocate human and technical resources to respond to the emergency. Many urologists became integrated into multidisciplinary teams, dealing with this respiratory illness and its unknown management. It aims to summarize the epidemiological, clinical, diagnostical, and therapeutical characteristics of COVID-19, from a practical perspective, to ease COVID-19 management to non-physician staff. RECENT FINDINGS: We performed a narrative review of the literature regarding COVID-19, updated to May 8th, 2020, at PubMed and COVID resource platforms of the main scientific editorials. COVID-19, characterized by fever, myalgias, dyspnea, and dry cough, varies widely from asymptomatic infection to death. Arrhythmias and thrombotic events are prevalent. Lymphopenia and inflammatory reactant elevation on laboratory, as well as bilateral and peripheral ground-glass opacities or consolidations on X-Ray, are usually found in its assessment. Little is known about SARS-CoV-2 immunology. To date, no therapy has demonstrated efficacy in COVID-19. Of-level or compassionate-use therapies are prescribed in the context of clinical trials. We should become familiar with specific adverse events and pharmacological interactions. SUMMARY: The COVID-19 pandemic has paralyzed the urological activity, and its long-term consequences are unpredictable. Despite not being used to deal with respiratory diseases, the urologists become easily qualified to manage COVID-19 by following protocols and being integrated into multidisciplinary teams, helping to overcome the pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32870407/ doi: 10.1007/s11934-020-00995-y id: cord-332013-bl5d4xkc author: Sánchez-Álvarez, J. Emilio title: Status of SARS-CoV-2 infection in patients on renal replacement therapy Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN) date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Summary The recent appearance of the SARS-CoV-2 coronavirus pandemic has had a significant impact on the general population. Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they are especially vulnerable. We present the results of the analysis of the COVID-19 Registry of the Spanish Society of Nephrology. Material and methods The Registry began operating on March 18th, 2020. It collects epidemiological variables, contagion and diagnosis data, signs and symptoms, treatments and outcomes. It is an “online” registry. Patients were diagnosed with SARS-Cov-2 infection based on the results of the PCR of the virus, carried out both in patients who had manifested compatible symptoms or had suspicious signs, as well as in those who had undergone screening after some contact. acquainted with another patient. Results As of April 11, the Registry had data on 868 patients, from all the Autonomous Communities. The most represented form of TRS is in-center hemodialysis (ICH) followed by transplant patients. Symptoms are similar to the general population. A very high percentage (85%) required hospital admission, 8% in intensive care units. The most used treatments were hydroxychloroquine, lopinavir-ritonavir, and steroids. Mortality is high and reaches 23%; deceased patients were more frequently on ICH, developed pneumonia more frequently, and received less frequently lopinavir-ritonavir and steroids. Age and pneumonia were independently associated with the risk of death. Conclusions SARS-CoV-2 infection already affects a significant number of Spanish patients on RRT, mainly those on ICH, hospitalization rates are very high and mortality is high; age and the development of pneumonia are factors associated with mortality. url: https://api.elsevier.com/content/article/pii/S201325142030050X doi: 10.1016/j.nefroe.2020.04.002 id: cord-033778-u2r0neyc author: Taban, EM title: Observational study of therapeutic bronchoscopy in critical hypoxaemic ventilated patients with COVID-19 at Mediclinic Midstream Private Hospital in Pretoria, South Africa date: 2020-10-13 words: 2577.0 sentences: 146.0 pages: flesch: 48.0 cache: ./cache/cord-033778-u2r0neyc.txt txt: ./txt/cord-033778-u2r0neyc.txt summary: Flexible fibreoptic bronchoscopy (FFB) has been used for years as a diagnostic and therapeutic adjunct for the diagnosis of potential airway obstruction as a cause of acute respiratory failure or in the management of hypoxaemia ventilated patients. To evaluate the use of FFB as a rescue therapy in mechanically ventilated patients with severe hypoxaemic respiratory failure caused by COVID-19. Patients with severe COVID-19 pneumonia who have persistent hypoxaemia despite the resolution of inflammatory parameters may respond to FFB with removal of mucus plugs. These patients had severe COVID-19 pneumonia with the following characteristics: severe refractory hypoxaemia despite maximal mechanical ventilatory support, including proning and significant deterioration from previous minimal ventilator settings. We have demonstrated that some patients with severe COVID-19 pneumonia and persistent hypoxaemia despite resolution of inflammatory parameters may respond to FFB following removal of mucus plugs. abstract: Background. Flexible fibreoptic bronchoscopy (FFB) has been used for years as a diagnostic and therapeutic adjunct for the diagnosis of potential airway obstruction as a cause of acute respiratory failure or in the management of hypoxaemia ventilated patients. In these circumstances, it is useful to evaluate airway patency or airway damage and for the management of atelectasis. Objectives. To evaluate the use of FFB as a rescue therapy in mechanically ventilated patients with severe hypoxaemic respiratory failure caused by COVID-19. Methods. We enrolled 14 patients with severe and laboratory confirmed COVID-19 who were admitted at Mediclinic Midstream Private Hospital intensive care unit in Pretoria, South Africa, in July 2020. Results. FFB demonstrated the presence of extensive mucus plugging in 64% (n=9/14) of patients after an average of 7.7 days of mechanical ventilation. Oxygenation improved significantly in these patients following FFB despite profound procedural hypoxaemia. Conclusions. Patients with severe COVID-19 pneumonia who have persistent hypoxaemia despite the resolution of inflammatory parameters may respond to FFB with removal of mucus plugs. We propose consideration of an additional pathophysiological acute phenotype of respiratory failure, the mucus type (M-type). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560156/ doi: 10.7196/ajtccm.2020.v26i4.119 id: cord-301579-q23nhmgs author: Tabaza, Luai title: Robotic‐assisted percutaneous coronary intervention in a COVID‐19 patient date: 2020-05-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease‐2019 (COVID‐19) pandemic is the biggest global health threat in the 21st century. We describe a case of a patient with suspected COVID‐19 who needed urgent coronary artery interrogation, in which we utilized robotic assistance to minimize the risk of exposure to COVID‐19 and reduced personal protective equipment needed by the procedural team. url: https://doi.org/10.1002/ccd.28982 doi: 10.1002/ccd.28982 id: cord-257051-ntnfu5ns author: Tack, Christopher Topol title: “Physio Anywhere”: digitally-enhanced outpatient care as a legacy of coronavirus 2020 date: 2020-07-18 words: 1380.0 sentences: 77.0 pages: flesch: 40.0 cache: ./cache/cord-257051-ntnfu5ns.txt txt: ./txt/cord-257051-ntnfu5ns.txt summary: Remote working via telemedicine (telephone or video-assisted consultation) displaces the need for face-to-face contact whilst providing care within patients'' own homes [2] . Despite the relative infancy of remote working in physiotherapy, there is an emerging body of evidence that supports its incorporation in clinical practice as both an assessment and rehabilitation tool. However, telemedicine, aided by an ever-increasing number of digital health tools, can significantly increase patients'' confidence in undertaking exercise and improve compliance and adherence to exercise-based rehabilitation programmes, compared to usual physiotherapy care [21] [22] . Digital health tools provide images and videos J o u r n a l P r e -p r o o f of exercises, patient advice and education and include reminders for patients to carry out prescribed exercise programs given by their physiotherapist in a ''virtual'' exercise class, which can be remotely delivered and adherence monitored. abstract: nan url: https://api.elsevier.com/content/article/pii/S0031940620303904 doi: 10.1016/j.physio.2020.07.004 id: cord-271220-sntawlnf author: Tadic, Marijana title: COVID‐19 and diabetes: Is there enough evidence? date: 2020-05-29 words: 2431.0 sentences: 127.0 pages: flesch: 42.0 cache: ./cache/cord-271220-sntawlnf.txt txt: ./txt/cord-271220-sntawlnf.txt summary: Additionally, data indicate that hypertension, diabetes, and cardiovascular diseases are important risk factors for progression and unfavorable outcome in COVID‐19 patients. Even though the number of studies with follow-up is rather limited, these data are suggesting that hypertension, diabetes, and cardiovascular disease are underlying conditions associated with adverse outcome-admission in intensive care unit, mechanic ventilation, and death [6] [7] [8] [9] 13, 18 (Table 3) . In one of the largest study published (n = 1099) so far, diabetes was present in 7.4% of COVID-19 patients and it was significantly more prevalent in patients with severe form of disease and those who experienced primary outcome end point (admission to an intensive care unit, the use of mechanical ventilation, or death). In meta-analysis that included 1558 patients with COVID-19, it was found that diabetes, as well as hypertension and chronic obstructive pulmonary disease, was associated with exacerbation and admission to intensive care unit. abstract: The pandemic of COVID‐19, a disease caused by a novel coronavirus SARS‐CoV‐2, is associated with significant morbidity and mortality. Recent data showed that hypertension, diabetes mellitus, cardiovascular diseases, and chronic obstructive pulmonary disease were the most prevalent comorbidities in COVID‐19 patients. Additionally, data indicate that hypertension, diabetes, and cardiovascular diseases are important risk factors for progression and unfavorable outcome in COVID‐19 patients. There is only limited amount of data regarding follow‐up of these patients, and they provided conflicting results. The main limitation is a small number of participants and particularly those who experienced primary composite outcome (admission in intensive care unit, use of mechanical ventilation, or death). Additionally, the limited number of patients was essential obstacle for performing analysis that would include many confounding factors such as advanced age, smoking status, and obesity and potentially change conclusion. So far, there is no study that demonstrated independent predictive value of diabetes on mortality in COVID‐19 patients, but there are many speculations about the association between diabetes and susceptibility to novel coronavirus, as well as its impact on progression and prognosis of COVID‐19. The aim of this review article was to summarize the current knowledge about the relationship between diabetes and COVID‐19 and its role in outcome in these patients. url: https://doi.org/10.1111/jch.13912 doi: 10.1111/jch.13912 id: cord-300995-tqz2bkdo author: Tagliaferri, Luca title: Skin cancer triage and management during COVID‐19 pandemic date: 2020-04-25 words: 1411.0 sentences: 65.0 pages: flesch: 45.0 cache: ./cache/cord-300995-tqz2bkdo.txt txt: ./txt/cord-300995-tqz2bkdo.txt summary: The worldwide medical community is striving to pursue the most appropriate clinical choices in the worst event of pandemic of the modern times [1], with over 1 million patients affected by COVID‐19 (i.e., swab positive patients with or without symptoms) reported so far [1]. The worldwide medical community is striving to pursue the most appropriate clinical choices in the worst event of pandemic of the modern times [1] , with over 1 million patients affected by COVID-19 (i.e., swab positive patients with or without symptoms) reported so far [2] . All rights reserved We therefore propose that the oncological risk and the risk of SARS-CoV-2 infection need to be considered and balanced in order to provide a weighted and controlled strategy to advanced skin cancer patients. A useful approach, as already suggested by other authors, is to identify the different classes of priorities, both for the patients and for health professionals [5, 6] .Only a few national and international societies have released specific recommendations for skin cancer patients [7] . abstract: The worldwide medical community is striving to pursue the most appropriate clinical choices in the worst event of pandemic of the modern times [1], with over 1 million patients affected by COVID‐19 (i.e., swab positive patients with or without symptoms) reported so far [1]. In this context, the aim of the ideal management of cancer patients is to achieve the best possible balance between the two different issues to be considered, which include the risk of cancer progression and the risk of infectious disease. url: https://doi.org/10.1111/jdv.16529 doi: 10.1111/jdv.16529 id: cord-287497-93oiiqqi author: Tagliamento, Marco title: Italian survey on managing immune checkpoint inhibitors in oncology during COVID‐19 outbreak date: 2020-06-14 words: 3228.0 sentences: 199.0 pages: flesch: 49.0 cache: ./cache/cord-287497-93oiiqqi.txt txt: ./txt/cord-287497-93oiiqqi.txt summary: The objectives of this survey were to examine the impact of COVID-19 outbreak on the perception of Italian physicians involved in the administration of ICIs about SARS-CoV-2 related risks in cancer patients receiving these therapies, and their attitudes towards the management of ICIs in oncology. The perception of respondents regarding the potential increased risk of severe events related to SARS-CoV-2 infection in cancer patients treated with ICIs is displayed in Figure 1B . 17 Moreover, besides the overlapping between cancer-related signs/symptoms or side effects of oncological treatments (including irAEs) and COVID-19 manifestations, additional issues could emerge from the differential diagnosis between radiological findings of lung involvement from SARS-CoV-2 and pneumonitis induced by ICIs. 9, 24 To the best of our knowledge, this is the first study exploring the perception of physicians towards these unsolved issues, and whether the outbreak has modified the clinical practice in managing the treatment with ICIs in oncology. abstract: BACKGROUND: During COVID‐19 outbreak, oncological care has been reorganized. Cancer patients have been reported to experience a more severe COVID‐19 syndrome; moreover, there are concerns of an interference between immune checkpoint inhibitors (ICIs) and SARS‐CoV‐2 pathogenesis. MATERIALS AND METHODS: Between May 6 and 16, 2020, a 22‐item survey was sent to Italian physicians involved in administering ICIs. It aimed to explore the perception about SARS‐CoV‐2 related risks in cancer patients receiving ICIs, and the attitudes towards their management. RESULTS: The 104 respondents had a median age of 35.5 years, 58.7% were females and 71.2% worked in Northern Italy. 47.1% of respondents argued a synergism between ICIs and SARS‐CoV‐2 pathogenesis leading to worse outcomes, but 97.1% would not deny an ICI only for the risk of infection. During COVID‐19 outbreak, to reduce hospital visits, 55.8% and 30.8% opted for the highest labeled dose of each ICI (55.8%) and/or, among different ICIs for the same indication, for the one with the longer interval between cycles, respectively. 53.8% of respondents suggested testing for SARS‐CoV‐2 every cancer patient candidate to ICIs. 71.2% declared to manage patients with onset of dyspnea and cough as SARS‐CoV‐2 infected until otherwise proven; however, 96.2% did not reduce the use of steroids to manage immune‐related toxicities. The administration of ICIs in specific situations for different cancer types has not been drastically conditioned. CONCLUSIONS: These results highlight the confusion around the perception of a potential interference between ICIs and COVID‐19, supporting the need of focused studies on this topic. url: https://doi.org/10.1111/eci.13315 doi: 10.1111/eci.13315 id: cord-273614-qmp2tqtb author: Tahir, Faryal title: Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): A Comprehensive Review date: 2020-05-08 words: 7164.0 sentences: 413.0 pages: flesch: 53.0 cache: ./cache/cord-273614-qmp2tqtb.txt txt: ./txt/cord-273614-qmp2tqtb.txt summary: However, multiple studies that highlight the clinical features, laboratory findings, and prognosis of acute myocardial injury (AMI) in COVID-19-affected individuals have been published. The study concluded that severe respiratory illness with 2019n-CoV infection with deteriorating complications was associated with ICU admission and a higher mortality rate [24] . This study concluded that patients with very severe COVID-19 have a higher percentage of increased cTnI levels and their mortality rate can be improved by protecting them from myocardial injury [40] . The study concluded that cardiac injury is a prevalent condition among hospitalized patients with COVID-19 in Wuhan, China, and it is associated with a higher risk of in-hospital mortality [41] . Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study (Epub ahead of print) Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China (Epub ahead of print) abstract: Since its origin in China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a pandemic and spread to 209 countries. As coronavirus disease 2019 (COVID-19) is a very rapidly emerging disease, organ-specific studies related to it have been reported. Apart from respiratory findings, some studies have highlighted inflammatory consequences in the heart, kidney, and/or liver as well. Cardiac involvement in COVID-19 seems to be a result of an inflammatory storm in response to the infection. Moreover, direct viral invasion of cardiomyocytes, as well as a myocardial injury due to oxidative stress, may account for acute cardiac injury in COVID-19. Nevertheless, the mechanism of heart injury in COVID-19 is not clear yet. However, multiple studies that highlight the clinical features, laboratory findings, and prognosis of acute myocardial injury (AMI) in COVID-19-affected individuals have been published. In this review, we have summarized the findings of all those studies as well as the clinical features and management of cardiac injury discussed by some case reports. url: https://www.ncbi.nlm.nih.gov/pubmed/32528760/ doi: 10.7759/cureus.8021 id: cord-327148-dzozl70h author: Tahmassebi, Ramon title: Reflections from London’s Level-1 Major Trauma Centres during the COVID crisis date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Emergence of the Covid-19 pandemic resulted in dramatic changes in global healthcare provision. Resources were redirected across all healthcare sectors to support the treatment of viral pneumonia with resultant effects on other essential services. We describe the impact of this on the provision of major trauma care in a major capital city. url: https://www.ncbi.nlm.nih.gov/pubmed/32591913/ doi: 10.1007/s00590-020-02724-0 id: cord-287765-nsdequl9 author: Taiwo, Olutosin title: Smart healthcare support for remote patient monitoring during covid-19 quarantine date: 2020-09-15 words: 7111.0 sentences: 359.0 pages: flesch: 50.0 cache: ./cache/cord-287765-nsdequl9.txt txt: ./txt/cord-287765-nsdequl9.txt summary: To this end, a remote smart home healthcare support system (ShHeS) is proposed for monitoring patients'' health status and receiving doctors'' prescriptions while staying at home. In this paper, we propose a mobile application-based prototype smart home healthcare system for efficient and effective health monitoring for the elderly and disabled for their convenient and independent living while at home. Smart home automation as an emerging area of IoT has been applied in various areas such as: easy and assisted daily living especially for the provision of support to humans [17] , remote control of home appliances [18, 19] , detection of movement in the house [20] , energy management in the home [21] and security [22] , and provision of healthcare services to out-patients, disabled and elderly persons [10, 23, 24] . The proposed system described in our work is intended to perform a dual function of controlling home appliances as well as monitoring and recording the patient''s physiological data such as blood pressure, body temperature, pulse rate, body weight and sugar level and other symptoms related to a specific virus. abstract: Social distancing and quarantining are now standard practices which are implemented worldwide since the outbreak of the novel coronavirus (COVID-19) disease pandemic in 2019. Due to the full acceptance of the above control practices, frequent hospital contact visits are being discouraged. However, there are people whose physiological vital needs still require routine monitoring for improved healthy living. Interestingly, with the recent technological advancements in the areas of Internet of Things (IoT) technology, smart home automation, and healthcare systems, contact-based hospital visits are now regarded as non-obligatory. To this end, a remote smart home healthcare support system (ShHeS) is proposed for monitoring patients’ health status and receiving doctors’ prescriptions while staying at home. Besides this, doctors can also carry out the diagnosis of ailments using the data collected remotely from the patient. An android based mobile application that interfaces with a web-based application is implemented for efficient patients-doctors dual real-time communication. Sensors are incorporated in the system for automatic capturing of physiological health parameters of patients. Also, a hyperspace analogue to context (HAC) was incorporated into the current monitoring framework for service discovery and context change in the home environment towards accurate readings of the physiological parameters and improved system performance. With the proposed system, patients can be remotely monitored from their homes, and can also live a more comfortable life through the use of some features of smart home automation devices on their phones. Therefore, one main significant contribution of this study is that patients in self-isolation or self-quarantine can use the new platform to send daily health symptoms and challenges to doctors via their mobile phones. Thus, improved healthy living and a comfortable lifestyle can still be achieved even during such a problematic period of the 2019 COVID-19 pandemic that has already recorded 20,026,186 million cases so far with 734,020 thousand deaths globally. url: https://www.ncbi.nlm.nih.gov/pubmed/32953970/ doi: 10.1016/j.imu.2020.100428 id: cord-265230-ozyx8u64 author: Takahari, Daisuke title: Managing a gastrointestinal oncology practice in Japan during the COVID-19 pandemic: single institutional experience in The Cancer Institute Hospital of Japanese Foundation for Cancer Research date: 2020-10-21 words: 5741.0 sentences: 276.0 pages: flesch: 42.0 cache: ./cache/cord-265230-ozyx8u64.txt txt: ./txt/cord-265230-ozyx8u64.txt summary: In order to reduce the use of medical resources to avoid the risk of COVID-19 infections in both cancer patients and health care providers, oncologists now have to draw the line for cancer treatments by maintaining their efficacy while avoiding severe adverse events. By contrast, for treating patients with high risk and/or during the pandemic, we must choose between reducing the intensity of chemotherapy (e.g., omission of the 5-FU bolus for CRC, replacement of infusional 5-FU by capecitabine or S-1 for ESCC, gastric cancer (GC), and CRC), delaying treatment, skipping cycles, or stopping (i.e., treatment maintenance phase and salvage chemotherapy with relatively few benefits). As first-line chemotherapy, for patients with high tumor burden or tumor-related signs/symptoms or low risk of COVID-19 infection, combination of fluoropyrimidine and oxaliplatin (if HER2 is positive, plus trastuzumab) is recommended as a standard regimen [38] . abstract: Coronavirus disease 2019 (COVID-19) was declared to be a global pandemic by the World Health Organization on March 11, 2020. On April 7, 2020, a state of emergency was declared in Japan, as had been by other nations worldwide. This unprecedented crisis has profound implications for patients undergoing chemotherapy and for practicing healthcare professionals. Various reports have shown data indicating that cancer patients with COVID-19 have high morbidity and mortality rates. In order to reduce the use of medical resources to avoid the risk of COVID-19 infections in both cancer patients and health care providers, oncologists now have to draw the line for cancer treatments by maintaining their efficacy while avoiding severe adverse events. In this article, we outlined the decisions made regarding the practice of gastrointestinal oncology in our institution during the COVID pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/33085057/ doi: 10.1007/s10147-020-01806-7 id: cord-352579-ndcbmgfj author: Takahashi, Takuto title: Pharmacogenomics of COVID-19 therapies date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A new global pandemic of coronavirus disease 2019 (COVID-19) has resulted in high mortality and morbidity. Currently numerous drugs are under expedited investigations without well-established safety or efficacy data. Pharmacogenomics may allow individualization of these drugs thereby improving efficacy and safety. In this review, we summarized the pharmacogenomic literature available for COVID-19 drug therapies including hydroxychloroquine, chloroquine, azithromycin, remdesivir, favipiravir, ribavirin, lopinavir/ritonavir, darunavir/cobicistat, interferon beta-1b, tocilizumab, ruxolitinib, baricitinib, and corticosteroids. We searched PubMed, reviewed the Pharmacogenomics Knowledgebase (PharmGKB(®)) website, Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines, the U.S. Food and Drug Administration (FDA) pharmacogenomics information in the product labeling, and the FDA pharmacogenomics association table. We found several drug-gene variant pairs that may alter the pharmacokinetics of hydroxychloroquine/chloroquine (CYP2C8, CYP2D6, SLCO1A2, and SLCO1B1); azithromycin (ABCB1); ribavirin (SLC29A1, SLC28A2, and SLC28A3); and lopinavir/ritonavir (SLCO1B1, ABCC2, CYP3A). We also identified other variants, that are associated with adverse effects, most notable in hydroxychloroquine/chloroquine (G6PD; hemolysis), ribavirin (ITPA; hemolysis), and interferon β -1b (IRF6; liver toxicity). We also describe the complexity of the risk for QT prolongation in this setting because of additive effects of combining more than one QT-prolonging drug (i.e., hydroxychloroquine/chloroquine and azithromycin), increased concentrations of the drugs due to genetic variants, along with the risk of also combining therapy with potent inhibitors. In conclusion, although direct evidence in COVID-19 patients is lacking, we identified potential actionable genetic markers in COVID-19 therapies. Clinical studies in COVID-19 patients are deemed warranted to assess potential roles of these markers. url: https://www.ncbi.nlm.nih.gov/pubmed/32864162/ doi: 10.1038/s41525-020-00143-y id: cord-007009-4wbvdg1r author: Takahashi, Toru title: The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan date: 2014-03-15 words: 4686.0 sentences: 236.0 pages: flesch: 47.0 cache: ./cache/cord-007009-4wbvdg1r.txt txt: ./txt/cord-007009-4wbvdg1r.txt summary: Severe fever with thrombocytopenia syndrome (SFTS), an infectious disease with a high case-fatality rate, is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic to central and northeastern parts of China [1, 2] . Vero cells were inoculated with RT-PCR-positive patient sera for virus isolation, cultured for 4-7 days, and examined for SFTSV antigen detection by indirect immunofluorescence assay (IFA) with a polyclonal antibody raised against SFTSV recombinant NP (rNP; rabbit anti-SFTSV rNP serum), which was produced as follows. Physicians were asked to volunteer information if they had treated patients who satisfied the following case definition: (1) fever of >38°C; (2) gastrointestinal tract symptoms, such as nausea, vomiting, abdominal pain, diarrhea, and melena; (3) thrombocytopenia, with <100 × 10 9 platelets/L; (4) leukopenia, with <4 × 10 9 white blood cells/L; (5) elevated levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase; (6) absence of other causes; and (7) death or admission to an intensive care unit because of the severity symptoms. Detection of severe fever with thrombocytopenia syndrome virus (SFTSV) RNA in the right cervical lymph node by the in situ hybridization ATtailing method. abstract: Background. Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. This article describes the first identified patient with SFTS and a retrospective study on SFTS in Japan. Methods. Virologic and pathologic examinations were performed on the patient's samples. Laboratory diagnosis of SFTS was made by isolation/genome amplification and/or the detection of anti-SFTSV immunoglobulin G antibody in sera. Physicians were alerted to the initial diagnosis and asked whether they had previously treated patients with symptoms similar to those of SFTS. Results. A female patient who died in 2012 received a diagnosis of SFTS. Ten additional patients with SFTS were then retrospectively identified. All patients were aged ≥50 years and lived in western Japan. Six cases were fatal. The ratio of males to females was 8:3. SFTSV was isolated from 8 patients. Phylogenetic analyses indicated that all of the Japanese SFTSV isolates formed a genotype independent to those from China. Most patients showed symptoms due to hemorrhage, possibly because of disseminated intravascular coagulation and/or hemophagocytosis. Conclusions. SFTS has been endemic to Japan, and SFTSV has been circulating naturally within the country. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107388/ doi: 10.1093/infdis/jit603 id: cord-352557-l7sahv5t author: Takla, Michael title: Chloroquine, hydroxychloroquine, and COVID-19: systematic review and narrative synthesis of efficacy and safety date: 2020-11-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has required clinicians to urgently identify new treatment options or the re-purposing of existing drugs. Of particular interest are chloroquine (CQ) and hydroxychloroquine (HCQ). The aims of this systematic review are to systematically identify and collate 24 studies describing the use of CQ and HCQ in human clinical trials and to provide a detailed synthesis of evidence of its efficacy and safety. Of clinical trials, 100% showed no significant difference in the probability of viral transmission or clearance in prophylaxis or therapy, respectively, compared to the control group. Among observational studies employing an endpoint specific to efficacy, 58% concurred with the finding of no significant difference in the attainment of outcomes. Three-fifths of clinical trials and half of observational studies examining an indicator unique to drug safety discovered a higher probability of adverse events in those treated patients suspected of, and diagnosed with, COVID-19. Of the total papers focusing on cardiac side-effects, 44% found a greater incidence of QTc prolongation and/or arrhythmias, 44% found no evidence of a significant difference, and 11% mixed results. The strongest available evidence points towards the inefficacy of CQ and HCQ in prophylaxis or in the treatment of hospitalised COVID-19 patients. url: https://api.elsevier.com/content/article/pii/S1319016420302644 doi: 10.1016/j.jsps.2020.11.003 id: cord-297001-4g3wb8qi author: Tal, Shir title: Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? date: 2020-05-12 words: 4626.0 sentences: 236.0 pages: flesch: 47.0 cache: ./cache/cord-297001-4g3wb8qi.txt txt: ./txt/cord-297001-4g3wb8qi.txt summary: Understanding the true impact of VTE on patients with COVID-19 will potentially improve our ability to reach a timely diagnosis and initiate proper treatment, mitigating the risk for this susceptible population during a complicated disease. However, many of the COVID-19 patients may present with high levels of D-dimer due to other causes -inflammation, disseminated intravascular coagulation, advanced age, or infection [23] suggesting the need for CTPA as an initial rule-out test as well. Finally, based on the correlation between high levels of D-dimer and severe COVID-19 disease [7, 37] as well as higher mortality rate [5, 38] , the International Society on Thrombosis and Haemosthasis (ISTH) and American Society of Hematology (ASH) guidelines [39] advises prophylactic LMWH in all hospitalized COVID-19 patients in the absence of any contraindications (active bleeding and platelet count less than 25 × 10 9 /L) [34, 40] . abstract: Coronavirus disease (COVID-19) is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is responsible for the ongoing 2019–2020 pandemic. Venous thromboembolism (VTE), a frequent cardiovascular and/or respiratory complication among hospitalized patients, is one of the known sequelae of the illness. Hospitalized COVID-19 patients are often elderly, immobile, and show signs of coagulopathy. Therefore, it is reasonable to assume a high incidence of VTE among these patients. Presently, the incidence of VTE is estimated at around 25% of patients hospitalized in the intensive care unit for COVID-19 even under anticoagulant treatment at prophylactic doses. In this review, we discuss present knowledge of the topic, the unique challenges of diagnosis and treatment of VTE, as well as some of the potential mechanisms of increased risk for VTE during the illness. Understanding the true impact of VTE on patients with COVID-19 will potentially improve our ability to reach a timely diagnosis and initiate proper treatment, mitigating the risk for this susceptible population during a complicated disease. url: https://doi.org/10.1159/000508233 doi: 10.1159/000508233 id: cord-316432-xemz7zn9 author: Talaie, Haleh title: Is there any potential management against COVID-19? A systematic review and meta-analysis date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: A recent survey has shown that the COVID-19 pandemic has culminated in dramatical and critical treatment particularly in acute infected patients. In fact, this systematic review-meta-analysis was directly pertained to estimation at the efficient value of some clinical managements to confront the COVID-19 infection. METHODS: Pubmed, Embase, Scopus, Cochrane, and Scholar databases were searched from inception to July 1, 2020, to identify studies reporting the current treatment process and medications (e.g. hydroxychloroquine, antiviral therapy, convalescent plasma, and immunomodulatory agents) for COVID-19. A random-effects model meta-analysis was performed to calculate the relative risk (RR) with 95% confidence intervals (CI). The outcomes of this study were the frequency of negative conversion cases, clinical improvements, mechanical ventilation demand, intensive care unit (ICU) entry, and mortality. The standard treatment refers to the published guidelines and specialist experience which varies in different articles, and the proposed treatment refers to the kind of interest suggested in the included studies. RESULTS: A number of 45 articles met the eligibility criteria (out of 6793 articles). Among them, 26 articles involving 3263 patients were included in quantitative analysis. Anti-COVID-19 interventions could significantly increase clinical improvement (RR 1.17, 95% CI 1.08–1.27; I(2) = 49.8%) and reduce the mortality rate (RR 0.58, 95% CI 0.35–0.95; I(2) = 74.8%). Although in terms of negative conversion, ICU entry, and mechanical ventilation demand, clinical intervention had no beneficial effect. The clinical effect of immunomodulatory agents (especially tocilizumab and anakinra) was noticeable compared to other medications with RR of 0.22 (95% CI 0.09–0.53; I(2) = 40.9%) for mortality and 1.25 (95% CI 1.07–1.46; I(2) = 45.4%) for clinical improvement. Moreover, Antivirals (RR 1.13, 95% CI 1.01–1.26; I(2) = 47.0%) and convalescent plasma therapy (RR 1.41, 95% CI 1.01–1.98; I(2) = 66.6%) had significant beneficial effects on clinical improvement. CONCLUSION: Based on our findings, all the included interventions significantly declined the mortality and enhanced clinical improvements with no effect on negative conversion and mechanical ventilation demand. Especially, immunomodulators and plasma therapy showed favorable outcomes. GRAPHICAL ABSTRACT: [Figure: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40199-020-00367-4) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s40199-020-00367-4 doi: 10.1007/s40199-020-00367-4 id: cord-264647-9r443j3l author: Talamonti, G. title: Spinal epidural abscess in COVID-19 patients date: 2020-09-10 words: 2920.0 sentences: 192.0 pages: flesch: 49.0 cache: ./cache/cord-264647-9r443j3l.txt txt: ./txt/cord-264647-9r443j3l.txt summary: OBJECTIVE: To report the peculiarity of spinal epidural abscess in COVID-19 patients, as we have observed an unusually high number of these patients following the outbreak of SARS-Corona Virus-2. METHODS: We reviewed the clinical documentation of six consecutive COVID-19 patients with primary spinal epidural abscess that we surgically managed over a 2-month period. A primary abscess represents the rarest form of spinal epidural abscess, which is usually secondary to invasive procedures or spread from adjacent infective sites, such as spondylodiscitis, generally occurring in patients with diabetes, obesity, cancer, or other chronic diseases. To our knowledge, cases of spinal epidural abscess in COVID-19 patients have not been reported to date. During the last three months, six patients with SARS-Corona Virus-2 (SARS-COV-2) were referred to us for acute spinal cord syndrome due to primary spinal epidural abscess (SEA) [1] . abstract: OBJECTIVE: To report the peculiarity of spinal epidural abscess in COVID-19 patients, as we have observed an unusually high number of these patients following the outbreak of SARS-Corona Virus-2. METHODS: We reviewed the clinical documentation of six consecutive COVID-19 patients with primary spinal epidural abscess that we surgically managed over a 2-month period. These cases were analyzed for what concerns both the viral infection and the spinal abscess. RESULTS: The abscesses were primary in all cases indicating that no evident infective source was found. A primary abscess represents the rarest form of spinal epidural abscess, which is usually secondary to invasive procedures or spread from adjacent infective sites, such as spondylodiscitis, generally occurring in patients with diabetes, obesity, cancer, or other chronic diseases. In all cases, there was mild lymphopenia but the spinal abscess occurred regardless of the severity of the viral disease, immunologic state, or presence of bacteremia. Obesity was the only risk factor and was reported in two patients. All patients but one were hypertensive. The preferred localizations were cervical and thoracic, whereas classic abscess generally occur at the lumbar level. No patient had a history of pyogenic infection, even though previous asymptomatic bacterial contaminations were reported in three cases. CONCLUSION: We wonder about the concentration of this uncommon disease in such a short period. To our knowledge, cases of spinal epidural abscess in COVID-19 patients have not been reported to date. We hypothesize that, in our patients, the spinal infection could have depended on the coexistence of an initially asymptomatic bacterial contamination. The well-known COVID-19-related endotheliitis might have created the conditions for retrograde bacterial invasion to the correspondent spinal epidural space. Furthermore, spinal epidural abscess carries a significantly high morbidity and mortality. It is difficult to diagnose, especially in compromised COVID-19 patients but should be kept in mind as early diagnosis and treatment are crucial. url: https://doi.org/10.1007/s00415-020-10211-z doi: 10.1007/s00415-020-10211-z id: cord-303192-il3s8lgp author: Tam, Lai‐Shan title: Care for patients with rheumatic diseases during COVID‐19 pandemic: A position statement from APLAR date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1111/1756-185x.13863 doi: 10.1111/1756-185x.13863 id: cord-252775-faxiem2w author: Tamagnini, Gabriele title: Cardiac surgery in the time of the novel coronavirus: Why we should think to a new normal date: 2020-07-15 words: 1722.0 sentences: 87.0 pages: flesch: 45.0 cache: ./cache/cord-252775-faxiem2w.txt txt: ./txt/cord-252775-faxiem2w.txt summary: The Cardiac Surgery Departments have to think to a new normal: since the virus will remain endemic in the society, dedicated pathways or even dedicated Teams are pivotal to treat safely the patients, in respect of the safety of the health care workers. Moreover, we need a keen eye on deciding which pathologies have to be treated with priority: Coronary artery Disease showed a higher mortality rate in patients affected by COVID19, but it is, however, reasonable to think that all the cardiac pathologies affecting the lung circulation—such as symptomatic severe mitral diseases or aortic stenosis—might deserve a priority access to treatment, to increase the survival rate in case of an acquired‐Coronavirus infection later on. In epidemiological terms, it would be reasonable to consider a comparison of the age-profile overlap among patients who suffered from more severe COVID-19 with patients who undergo cardiac surgical procedures, since both prevalence of valvular diseases and casefatality rates for COVID-19 increase in the elderly patients. abstract: On 11 March 2020, the World Health Organization declared the SARS‐CoV‐2 outbreak a pandemic. At the time of writing, 24 May 2020 more than 5 million individuals have been tested positive and the death toll was over 330 000 deaths worldwide. The initial data pointed out the tight bond between cardiovascular diseases and worse health outcomes in COVID19‐patients. Epidemiologically speaking, there is an overlap between the age‐groups more affected by COVID‐related death and the age‐groups in which Cardiac Surgery has its usual base of patients. The Cardiac Surgery Departments have to think to a new normal: since the virus will remain endemic in the society, dedicated pathways or even dedicated Teams are pivotal to treat safely the patients, in respect of the safety of the health care workers. Moreover, we need a keen eye on deciding which pathologies have to be treated with priority: Coronary artery Disease showed a higher mortality rate in patients affected by COVID19, but it is, however, reasonable to think that all the cardiac pathologies affecting the lung circulation—such as symptomatic severe mitral diseases or aortic stenosis—might deserve a priority access to treatment, to increase the survival rate in case of an acquired‐Coronavirus infection later on. url: https://www.ncbi.nlm.nih.gov/pubmed/32667077/ doi: 10.1111/jocs.14741 id: cord-291855-wtwz94sy author: Tambone, Vittoradolfo title: Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic date: 2020-06-16 words: 1149.0 sentences: 58.0 pages: flesch: 45.0 cache: ./cache/cord-291855-wtwz94sy.txt txt: ./txt/cord-291855-wtwz94sy.txt summary: title: Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic According to the above, we propose the following five ethical criteria for the triage of patients in conditions of limited resources, such as the COVID pandemic. It is rooted in the idea of human dignity, which gives birth to the humanitarian imperative conveyed in the first core principle of "disaster medicine"; the common good also means that, in a Global Health framework, patients are not just isolated individuals but persons with strong ties to their communities, and therefore both patient and community need to be taken into account (5); (b) no one must be abandoned or discriminated against for any reason (6); (c) before denying a necessary referral of a patient to an ICU, due to lack of resources, it is required to consider alternatives both for the immediate case and, based on the experience gained, for similar future cases. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32612972/ doi: 10.3389/fpubh.2020.00284 id: cord-264924-ds6jv5ek author: Tambyah, Paul A title: Severe acute respiratory syndrome from the trenches, at a Singapore university hospital date: 2004-11-30 words: 5458.0 sentences: 274.0 pages: flesch: 53.0 cache: ./cache/cord-264924-ds6jv5ek.txt txt: ./txt/cord-264924-ds6jv5ek.txt summary: Summary The epidemiology and virology of severe acute respiratory syndrome (SARS) have been written about many times and several guidelines on the infection control and public health measures believed necessary to control the spread of the virus have been published. The epidemiology and virology of severe acute respiratory syndrome (SARS) have been written about many times and several guidelines on the infection control and public health measures believed necessary to control the spread of the virus have been published. The severe acute respiratory syndrome (SARS) coronavirus is a novel pathogen that emerged in southern China at the end of 2002 and because of a single event in a hotel in Hong Kong one night in February 2003, spread to three continents. Mild illness associated with severe acute respiratory syndrome coronavirus infection: lessons from a prospective seroepidemiologic study of health-care workers in a teaching hospital in Singapore abstract: Summary The epidemiology and virology of severe acute respiratory syndrome (SARS) have been written about many times and several guidelines on the infection control and public health measures believed necessary to control the spread of the virus have been published. However, there have been few reports of the problems that infectious disease clinicians encounter when dealing with the protean manifestations of this pathogen. This is a qualitative account of some of the issues faced by an infectious disease physician when identifying and treating patients with SARS as well as protecting other healthcare workers and patients, including: identification of the chain of contagion, early recognition of the disease in the absence of a reliable and rapid diagnostic test, appropriate use of personal protective equipment, and the use of isolation to prevent super-spreading events. Many issues need to be addressed if clinicians are to be able to manage the virus should it reappear. url: https://www.ncbi.nlm.nih.gov/pubmed/15522681/ doi: 10.1016/s1473-3099(04)01175-2 id: cord-289006-7dv1zsp9 author: Tan, Kimberly-Anne title: Addressing Coronavirus Disease 2019 in Spine Surgery: A Rapid National Consensus Using the Delphi Method via Teleconference date: 2020-05-14 words: 4529.0 sentences: 219.0 pages: flesch: 43.0 cache: ./cache/cord-289006-7dv1zsp9.txt txt: ./txt/cord-289006-7dv1zsp9.txt summary: The following topics were discussed: repurposing of surgeons, continuity of spine services, introduction of telemedicine, triaging of spinal surgeries, preoperative testing, new challenges in performing spine surgery, and preparing for the post-pandemic era. The aforementioned challenges in clinical practice brought about by the COVID-19 pandemic raise the question of whether we can use present-day technology to improve patient care. The orthopedic spine service of the National University Hospital has had a long-standing tradition of auditing all upcoming spine surgery cases every week and has reported this to be especially beneficial during the COVID-19 pandemic where resource availability is constantly changing. While the following set of guidelines provide a framework to help spine services triage their patients, the need to continually evaluate the operating lists on a case-by-case and resource-dependent basis remains crucial during this pandemic. abstract: The magnitude and potential duration of the current coronavirus disease 2019 (COVID-19) pandemic is something that most doctors currently in practice have yet to experience. While considerable information regarding COVID-19 is being published every day, it is challenging to filter out the most relevant or appropriate information for our individual practice. The Spine Society of Singapore convened via a teleconference on April 24, 2020 to collaborate on a national level and share collective wisdom in order to tackle the ongoing crisis. In the teleconference, 13 spine surgeons from across various hospitals in Singapore constituted the panel of experts. The following topics were discussed: repurposing of surgeons, continuity of spine services, introduction of telemedicine, triaging of spinal surgeries, preoperative testing, new challenges in performing spine surgery, and preparing for the post-pandemic era. While some issues required only the sharing of best practices, the Delphi panel method was adopted to form a consensus on others. Existing spine specific triage guidelines were debated and a locally accepted set of guidelines was established. Although preoperative testing is currently not performed routinely, the panel voted in favor of its implementation because they concluded that it is vital to protect themselves, their colleagues, and their patients. Solutions to operating room specific concerns were also discussed. This article reflects the opinions and insights shared during this meeting and reviews the evidence relevant to the issues that were raised. The rapid consensus reached during the teleconference has enabled us to be concerted, and thus stronger, in our national efforts to provide the best standard of care via our spine services in these challenging times. We believe that this article will provide some guidance for addressing COVID-19 in spine surgery and encourage other national/regional societies to conduct similar discussions that would help their navigation of this pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32403894/ doi: 10.31616/asj.2020.0224 id: cord-301079-n1nytr6k author: Tan, Li title: Air and surface contamination by SARS-CoV-2 virus in a tertiary hospital in Wuhan, China date: 2020-07-27 words: 3556.0 sentences: 205.0 pages: flesch: 60.0 cache: ./cache/cord-301079-n1nytr6k.txt txt: ./txt/cord-301079-n1nytr6k.txt summary: Results A total of 367 air and surface swabbing samples were collected from the patient care areas of 15 mild and 9 severe/critical COVID-19 patients. Here we collected air and surface samples from isolation wards and ICU units of a tertiary hospital in Wuhan, with the aim to evaluate environmental contamination after enhancement of infection prevention and control measures (IPC) during the COVID-19 pandemic. We also compared environmental contamination of low-and high-touch surfaces, patient hands and PPE of HCP, and the results were also linked to clinical data of sampling patients. Another study found only 1 out of 14 surgical masks worn by mild and severe COVID-19 patients tested positive for SARS-CoV-2 . Environmental contamination of the SARS-CoV-2 viral RNA could be found even in seroconverted patients in healthcare settings, and the contamination risk was higher in high-touch areas near severe/critical patients. abstract: Abstract Background Few studies have explored the air and surface contamination by SARS-CoV-2 virus in healthcare settings. Methods We collected air and surface samples from the isolation wards and intensive care units designated for COVID-19 patients. The clinical data and tests result of nasopharyngeal specimens and serum antibodies were also collected from the sampling patients. Results A total of 367 air and surface swabbing samples were collected from the patient care areas of 15 mild and 9 severe/critical COVID-19 patients. Only one air sample taken during the intubation procedure tested positive. High-touch surfaces were slightly more likely contaminated by the RNA of the SARS-CoV-2 virus than low-touch surfaces. Contamination rates was slightly higher near severe/critical patients compared to those near mild patients, although not statistically significant (p <0.05). Surface contamination was still found near the patients with both positive IgG and IgM. Conclusions Air and surface contamination of the viral RNA was relatively low in healthcare settings after enhancement of infection prevention and control. Environmental contamination could still be found near seroconverted patients, suggesting the needs of maintaining constant vigilance in healthcare settings to reduce healthcare associated infection during the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32730827/ doi: 10.1016/j.ijid.2020.07.027 id: cord-297836-y9vt6wvu author: Tan, Yi Quan title: Re: Kristian D. Stensland, Todd M. Morgan, Alireza Moinzadeh, et al. Considerations in the Triage of Urologic Surgeries During the COVID-19 Pandemic. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.027: The Forgotten Urological Patient During the COVID-19 Pandemic: Patient Safety Safeguards date: 2020-05-08 words: 768.0 sentences: 54.0 pages: flesch: 45.0 cache: ./cache/cord-297836-y9vt6wvu.txt txt: ./txt/cord-297836-y9vt6wvu.txt summary: https://doi.org/10.1016/j.eururo.2020.03.027: The Forgotten Urological Patient During the COVID-19 Pandemic: Patient Safety Safeguards As described by Stensland et al [1] , urology services have been reduced significantly, with manpower and resources redeployed and reallocated to frontline departments, focusing attention to urgent-only cases during the COVID-19 pandemic [2] . In this letter, we add to the considerations provided by Stensland et al by highlighting important patient safety strategies and safeguards used at a tertiary urological centre amid the climate of resource scarcity during this pandemic. Our national university centre for organ transplantation maintained our cadaveric-donor and living-donor kidney transplantation programmes during this period, with rigorous protocols to screen donors and recipients for COVID-19 to prevent transmission to these immunocompromised patients. With the global focus on patients affected by COVID-19, appropriate levels of urological care must be maintained as patient safety safeguards, especially for certain vulnerable populations. abstract: nan url: https://api.elsevier.com/content/article/pii/S0302283820303407 doi: 10.1016/j.eururo.2020.04.072 id: cord-306090-i8sriw08 author: Tan, Zihui title: Protecting health care workers in the front line: Innovation in COVID-19 pandemic date: 2020-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.7189/jogh.10.010357 doi: 10.7189/jogh.10.010357 id: cord-324798-qh0cxp10 author: Tanaka, Miho title: Forgoing life-sustaining treatment – a comparative analysis of regulations in Japan, Korea, Taiwan, and England date: 2020-10-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Regulations on forgoing life-sustaining treatment (LST) have developed in Asian countries including Japan, Korea and Taiwan. However, other countries are relatively unaware of these due to the language barrier. This article aims to describe and compare the relevant regulatory frameworks, using the (more familiar) situation in England as a point of reference. We undertook literature reviews to ascertain the legal and regulatory positions on forgoing LST in Japan, Korea, Taiwan, and England. MAIN TEXT: Findings from a literature review are first presented to describe the development of the regulatory frameworks surrounding the option of forgoing LST in each country. Based on the findings from the four countries, we suggest five ethically important points, reflection on which should help to inform the further development of regulatory frameworks concerning end-of-life care in these countries and beyond. There should be reflection on: (1) the definition of – and reasons for defining – the ‘terminal stage’ and associated criteria for making such judgements; Korea and Taiwan limit forgoing LST to patients in this stage, but there are risks associated with defining this too narrowly or broadly; (2) foregoing LST for patients who are not in this stage, as is allowed in Japan and England, because here too there are areas of controversy, including (in England) whether the law in this area does enough to respect the autonomy of (now) incapacitated patients; (3) whether ‘foregoing’ LST should encompass withholding and withdrawing treatment; this is also an ethically disputed area, particularly in the Asian countries we examine; (4) the family’s role in end-of-life decision-making, particularly as, compared with England, the three Asian countries traditionally place a greater emphasis on families and communities than on individuals; and (5) decision-making with and for those incapacitated patients who lack families, surrogate decision-makers or ADs. CONCLUSION: Comparison of, and reflection on, the different legal positions that obtain in Japan, Korea, Taiwan, and England should prove informative and we particularly invite reflection on five areas, in the hope the ensuing discussions will help to establish better end-of-life regulatory frameworks in these countries and elsewhere. url: https://doi.org/10.1186/s12910-020-00535-w doi: 10.1186/s12910-020-00535-w id: cord-301811-ykpiorgo author: Tanaka, Takuma title: Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing date: 2020-10-28 words: 5530.0 sentences: 296.0 pages: flesch: 55.0 cache: ./cache/cord-301811-ykpiorgo.txt txt: ./txt/cord-301811-ykpiorgo.txt summary: title: Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing We estimated the numbers of undiagnosed symptomatic patients and the lower bound of the number of total infected individuals per diagnosed patient before and after the declaration of the state of emergency in Hokkaido, Japan. The present analysis uses the distributions of the cluster size and patients'' time from onset to diagnosis, which are released by the health officials, to estimate the model parameters. At the same time, the nodes in the connected component containing the diagnosed node are also removed from the network, which corresponds to the contact tracing of the infected individuals (Fig 2, gray open circles) . In this paper, we have formulated a model to describe the spreading of infection and the quarantine of infected individuals, and estimated the number of undiagnosed symptomatic and asymptomatic COVID-19 patients in Hokkaido. abstract: Estimating the percentages of undiagnosed and asymptomatic patients is essential for controlling the outbreak of SARS-CoV-2, and for assessing any strategy for controlling the disease. In this paper, we propose a novel analysis based on the birth-death process with recursive full tracing. We estimated the numbers of undiagnosed symptomatic patients and the lower bound of the number of total infected individuals per diagnosed patient before and after the declaration of the state of emergency in Hokkaido, Japan. The median of the estimated number of undiagnosed symptomatic patients per diagnosed patient decreased from 1.7 to 0.77 after the declaration, and the median of the estimated lower bound of the number of total infected individuals per diagnosed patient decreased from 4.2 to 2.4. We will discuss the limitations and possible expansions of the model. url: https://www.ncbi.nlm.nih.gov/pubmed/33112895/ doi: 10.1371/journal.pone.0241170 id: cord-024614-6bu3zo01 author: Tang, Daxing title: Prevention and control strategies for emergency, limited-term, and elective operations in pediatric surgery during the epidemic period of COVID-19 date: 2020-03-26 words: 5846.0 sentences: 300.0 pages: flesch: 43.0 cache: ./cache/cord-024614-6bu3zo01.txt txt: ./txt/cord-024614-6bu3zo01.txt summary: Based on the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19, the authors proposed some concrete measures and practical strategies of managing emergency, limited-term, and elective pediatric surgeries during the epidemic period. Based on the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19, the authors proposed some concrete measures and practical strategies of managing emergency, limited-term, and elective pediatric surgeries during the epidemic period. Based on the "Technical Guidelines for the Prevention and Control of New Coronavirus Infection in Medical Institutions (First Edition)," 17 "Diagnosis and Treatment Plan on the New Coronavirus inflicted pneumonia (Sixth trial edition, revised)" 2 (both released by the National Health Commission of China), "Recommendations for the Prevention and Control of General Surgery in the Background of New Coronavirus Outbreak," 6 and other relevant latest reports, we propose the following control measures and practical strategies for pediatric surgery practice during the COVID-19 epidemic. abstract: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to more than 100 countries. Children approved to be susceptible to SARS-CoV-2 infection. Preventing and controlling the epidemic while ensuring orderly flows of pediatric surgery clinical work has proven to be a big challenge for both patients and clinicians during the epidemic. Based on the transmission characteristics of SARS-CoV-2 and the requirements for prevention and control of COVID-19, the authors proposed some concrete measures and practical strategies of managing emergency, limited-term, and elective pediatric surgeries during the epidemic period. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211106/ doi: 10.1136/wjps-2020-000122 id: cord-344967-t88pedeb author: Tang, Hon Lok title: Severe acute respiratory syndrome in haemodialysis patients: a report of two cases date: 2003-10-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/13679500/ doi: 10.1093/ndt/gfg454 id: cord-003291-zuqx6ksy author: Tang, Pingping title: Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review date: 2018-11-03 words: 3054.0 sentences: 191.0 pages: flesch: 49.0 cache: ./cache/cord-003291-zuqx6ksy.txt txt: ./txt/cord-003291-zuqx6ksy.txt summary: title: Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review METHODS: A retrospective cohort study was conducted with 12 patients who were diagnosed with severe pneumonia complicating pregnancy at Peking Union Medical College Hospital between January 2010 and June 2017. High incidences of adverse fetal outcomes were observed; thus, termination of the pregnancy is recommended for patients in their third trimester when respiratory function deteriorates progressively. Several physiological and immunological changes that are experienced during pregnancy, such as altered T lymphocyte immunity, increased oxygen consumption, decreased functional residual capacity, decreased chest compliance, and increased risk of aspiration, may predispose pregnant women to a more severe course of pneumonia, which may result in greater maternal and fetal morbidity and mortality [1, 4] . The patients'' clinical data including symptoms at presentation, laboratory tests, and treatment strategies were reviewed carefully to screen for severe pneumonia. abstract: BACKGROUND: Pneumonia during pregnancy has been proven to be associated with increased maternal and fetal morbidity and mortality. The management of severe pneumonia in gravid patients is even more challenging. Thus, we summarized the characteristics and pregnancy outcomes of these patients and explored the probable risk factors and predictive factors for pneumonia during pregnancy and the appropriate timing of delivery in severe pneumonia patients. METHODS: A retrospective cohort study was conducted with 12 patients who were diagnosed with severe pneumonia complicating pregnancy at Peking Union Medical College Hospital between January 2010 and June 2017. The clinical features, treatment strategies, and pregnancy outcomes were collected from medical records and telephone calls. RESULTS: All 12 patients were in their late second or third trimester. The patients had a higher prevalence of anemia (50%) and preeclampsia (25%) than ordinary pregnant women. Delayed diagnoses were not uncommon. Two mothers died in our series, resulting in a mortality rate of 17%. Two intrauterine deaths were observed. Elective delivery was not performed in any of the four patients in their second trimester. Six of the seven patients who presented after 28 weeks of gestation and had live fetuses underwent emergency deliveries. Preterm births (6/7) and cesarean sections (5/7) were the two leading adverse outcomes in newborns. CONCLUSIONS: Anemia, advanced gestational age, and preeclampsia might be associated with the severity of pneumonia. Chest radiographs should be taken as soon as pneumonia is highly suspected to facilitate an early diagnosis. High incidences of adverse fetal outcomes were observed; thus, termination of the pregnancy is recommended for patients in their third trimester when respiratory function deteriorates progressively. However, it might be reasonable to continue pregnancy for those in their first or second trimester. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215647/ doi: 10.1186/s12884-018-2070-0 id: cord-346594-tbsxgz43 author: Tang, Sydney C. W. title: Peritoneal dialysis: the ideal bridge from conservative therapy to kidney transplant date: 2020-07-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Kidney transplantation offers the best potential for full rehabilitation in patients with end-stage kidney disease who are treated with dialysis. However, due to organ shortage which is a universal phenomenon, most patients need to be maintained on a period of dialysis therapy before the prospect of transplantation. Peritoneal dialysis (PD) could be an ideal form of renal replacement therapy due to its favorable profile toward preservation of residual renal function, patient survival, lower overall burden on cardiovascular morbidity and infection risks. METHODS: With extensive experience in PD therapy from Hong Kong where PD-first is a mandatory health policy, we reviewed the literature and present current evidence that favors PD as an optimal form of bridging renal replacement therapy prior to kidney transplantation. RESULTS: PD provides a viable and advantageous form of renal reaplcement particularly in terms of preservation of residual renal function, patient survival and quality of life, and cost among many other factors. Potential misconceptions that PD-related peritonitis and dialysis inadequacy are potentially deterrent factors for initiating PD therapy are clarified. CONCLUSION: PD is a practical and noninferior form of renal replacement that serves as an ideal bridge from conservative therapy to kidney transplantation. url: https://www.ncbi.nlm.nih.gov/pubmed/32654095/ doi: 10.1007/s40620-020-00787-0 id: cord-269275-b7xxk48t author: Tang, Xiaojia title: Neurological manifestations in COVID-19 and its possible mechanism date: 2020-09-27 words: 4631.0 sentences: 260.0 pages: flesch: 44.0 cache: ./cache/cord-269275-b7xxk48t.txt txt: ./txt/cord-269275-b7xxk48t.txt summary: SARS-CoV-2 has been reported to be associated with Guillain-Barré syndrome, rhabdomyolysis, acute cerebrovascular disease, central nervous system infections and other neurological diseases. Four formal reports have described neurological problems in SARS patients, including polyneuropathy [35] , myopathy and rhabdomyolysis [36] , large artery ischemic stroke [37] and central nervous system infections [38] . In a study by Mao et al., 214 patients diagnosed with COVID-19 were enrolled, and six (2.80%) of them developed acute cerebrovascular disease (five cases of ischemic stroke and one case of cerebral hemorrhage). Strokes are not uncommon in critically ill patients with multiple comorbidities, so SARS-CoV-2 infections in humans may increase the risk of stroke. Since some COVID-19 patients have complained of headaches, nausea etc, care providers should be alert for central nervous system infections caused by SARS-CoV-2 if such patients also exhibit symptoms such as a fever, epilepsy and disturbances of consciousness. abstract: In December 2019, the first cases of the acute respiratory illness now known as Corona Virus Disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. The main clinical manifestations of COVID-19 are a fever, dry cough and general weakness, although in some patients, a headache, tight chest, diarrhea, etc. are the first clinical manifestations. Neurological practice is involved in all aspects of medicine, from primary care for patients with migraines to consultations with patients in the intensive care unit. Few disorders spare the nervous system, and newly emerging infections are no exception. As neurologists, we are concerned about the effects of SARS-CoV-2 infections on the nervous system. Multiple neuropathy, rhabdomyolysis, cerebrovascular disease, central nervous system infections and other common neurological diseases require attention during this outbreak. url: https://doi.org/10.18632/aging.103732 doi: 10.18632/aging.103732 id: cord-256864-v3mxcwru author: Tang, Yueting title: Selection of an Optimal Combination Panel to Better Triage COVID-19 Hospitalized Patients date: 2020-10-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: It is difficult to predict the prognosis of COVID-19 patients at the disease onset. This study was designed to add new biomarkers into conventional inflammatory panels to build an optimal combination panel, to better triage patients and predict their outcomes. PATIENTS AND METHODS: Biochemical parameters representing multi-organ functions, cytokines, acute-phase proteins, and other inflammatory markers were measured in COVID-19 patients on hospital admission. Receiver operating characteristic (ROC) curves, logistic regression, event-free survival (EFS), and Cox analyses were performed to screen and compare the predictive capabilities of the new panel in patients with different illness severity and outcome. RESULTS: This study included 120 patients with COVID-19, consisting of 32 critical, 28 severe, and 60 mild/moderate patients. Initial levels of the selected biomarkers showed a significant difference in the three groups, all of which influenced patient outcome and EFS to varying degrees. Cox proportional hazard model revealed that procalcitonin (PCT) and interleukin 10 (IL-10) were independent risk factors, while superoxide dismutase (SOD) was an independent protective factor influencing EFS. In discriminating the critical and mild patients, a panel combining PCT, IL-6, and neutrophil (NEUT) yielded the best diagnostic performance with an AUC of 0.99, the sensitivity of 90.60% and specificity of 100%. In distinguishing between severe and mild patients, SOD’s AUC of 0.89 was higher than any other single biomarker. In differentiating the critical and severe patients, the combination of white blood cell count (WBC), PCT, IL-6, IL-10, and SOD achieved the highest AUC of 0.95 with a sensitivity of 75.00% and specificity of 100%. CONCLUSION: The optimal combination panel has a substantial potential to better triage COVID-19 patients on admission. Better triage of patients will benefit the rational use of medical resources. url: https://www.ncbi.nlm.nih.gov/pubmed/33149652/ doi: 10.2147/jir.s273193 id: cord-254777-h8hw4m9f author: Tanner, Tamara title: Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19 date: 2020-07-29 words: 4731.0 sentences: 248.0 pages: flesch: 42.0 cache: ./cache/cord-254777-h8hw4m9f.txt txt: ./txt/cord-254777-h8hw4m9f.txt summary: Cytokine storm syndromes include various entities, depending on the inciting factor: primary Hemophagocytic Lymphohistiocytosis [HLH] in children with specific genetic mutations; secondary HLH due to infection or malignancy, macrophage activation syndrome due to rheumatologic disease and cytokine release syndrome (CRS) when hyperinflammation is due to CAR T-cell therapy. Although still under investigation, ADE has been proposed as a potential mechanism underlying the newly described MIS-C, based on the observation that a majority of the patients have evidence of existing antibodies to SARS-CoV-2 and the inflammatory condition seems to lag behind the COVID-19 infection peak by approximately 4-6 weeks. The rationale for use of IL-6 blockade in serious COVID-19 infections is based on the observation that for the subset of patients with severe manifestations, IL-6 is most likely one of the drivers of the cytokine storm, and elevated levels of IL-6 have been consistently shown [14] . abstract: The rapid spread of SARS-CoV-2 infection globally coupled with the relatively high case-fatality rate has led to immediate need for therapeutic intervention to prevent and treat COVID-19 disease. There is accumulating evidence that morbidity and mortality in COVID-19 may be exacerbated by a dysregulated host immune response resulting in significant hyperinflammation and cytokine release. The aim of this review is to describe the basis for the immune dysregulation caused by SARS-CoV-2 infection and to examine current investigations into immunomodulatory therapies aimed at targeting the excessive host immune response. url: https://doi.org/10.1016/j.prrv.2020.07.003 doi: 10.1016/j.prrv.2020.07.003 id: cord-281175-og3myz22 author: Tapper, Elliot B. title: The COVID-19 pandemic will have a long-lasting impact on the quality of cirrhosis care date: 2020-04-13 words: 2675.0 sentences: 156.0 pages: flesch: 43.0 cache: ./cache/cord-281175-og3myz22.txt txt: ./txt/cord-281175-og3myz22.txt summary: The coronavirus disease 2019 (COVID-19) pandemic has shattered the meticulously developed processes by which we delivered quality care for patients with cirrhosis. We describe how this impact unfolds over 3 waves; i) an intense period with prioritized high-acuity care with delayed elective procedures and routine care during physical distancing, ii) a challenging ''return to normal'' following the end of physical distancing, with increased emergent decompensations, morbidity, and systems of care overwhelmed by the backlog of deferred care, and iii) a protracted period of suboptimal outcomes characterized by missed diagnoses, progressive disease and loss to follow-up. This includes an intensification of the preventative care provided to patients with compensated cirrhosis, proactive chronic disease management, robust telehealth programs, and a reorganization of care delivery to provide a full service of care with flexible clinical staffing. Coordination of care associated with survival and healthcare utilization in a population-based study of patients with cirrhosis abstract: The coronavirus disease 2019 (COVID-19) pandemic has shattered the meticulously developed processes by which we delivered quality care for patients with cirrhosis. Care has been transformed by the crisis, but enduring lessons have been learned. In this article, we review how COVID-19 will impact cirrhosis care. We describe how this impact unfolds over 3 waves; i) an intense period with prioritized high-acuity care with delayed elective procedures and routine care during physical distancing, ii) a challenging ‘return to normal’ following the end of physical distancing, with increased emergent decompensations, morbidity, and systems of care overwhelmed by the backlog of deferred care, and iii) a protracted period of suboptimal outcomes characterized by missed diagnoses, progressive disease and loss to follow-up. We outline the concrete steps required to preserve the quality of care provided to patients with cirrhosis. This includes an intensification of the preventative care provided to patients with compensated cirrhosis, proactive chronic disease management, robust telehealth programs, and a reorganization of care delivery to provide a full service of care with flexible clinical staffing. Managing the pandemic of a serious chronic disease in the midst of a global infectious pandemic is challenging. It is incumbent upon the entire healthcare establishment to be strong enough to weather the storm. Change is needed. url: https://www.sciencedirect.com/science/article/pii/S0168827820302178 doi: 10.1016/j.jhep.2020.04.005 id: cord-268632-p1rsz8fk author: Tartari, Federico title: Herpes zoster in COVID‐19‐positive patients date: 2020-06-12 words: 366.0 sentences: 34.0 pages: flesch: 57.0 cache: ./cache/cord-268632-p1rsz8fk.txt txt: ./txt/cord-268632-p1rsz8fk.txt summary: cord_uid: p1rsz8fk 1 The disease was defined as COVID-19 (Coronavirus Disease 2019) 1 and principally affects the respiratory tract with a clinical scenario ranging from common cold to severe pneumonia. 2 The clinical scenario differs with most patients only needing supportive care, while others require admission to an intensive care unit (ICU) for invasive mechanical ventilation. 2 In Italy, the first person-to-person transmission of the SARS-CoV-2 was recorded on February 21, 2020, and to date (04/28/2020) the number of COVID-19 positive subjects is more than 100,000. However, little is known on the cutaneous manifestations of COVID-19-positive patients. [3] [4] [5] We aim to expand our knowledge by reporting four zoster infections in COVID-19-positive patients observed between March and April 2020. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Decreased absolute numbers of CD3+ T cells and CD8+ T cells during aging in herpes zoster patients abstract: nan url: https://doi.org/10.1111/ijd.15001 doi: 10.1111/ijd.15001 id: cord-272112-egsha2j7 author: Tartarone, Alfredo title: COVID-19 and cancer care: what do international guidelines say? date: 2020-08-07 words: 2412.0 sentences: 111.0 pages: flesch: 43.0 cache: ./cache/cord-272112-egsha2j7.txt txt: ./txt/cord-272112-egsha2j7.txt summary: The recently published Italian recommendations advise to evaluate case by case the possibility of postponing a treatment, considering the biological aspects of cancer, the clinical characteristics of the patient and the potential health risks for COVID-19 infection [9] . According to French guidelines, clinical management of cancer patients during the COVID-19 pandemic should be based on the following priority order: curative or non-curative intent of the treatment, age, life expectancy, time since diagnosis and symptoms [11] . TERAVOLT data confirmed a high mortality rate among patients with lung cancer who develop COVID-19; in both studies similar independent factors were associated with increased mortality, which included older age, number of comorbidities, poor performance status, active cancer and administration of chemotherapy alone or in combination with other treatments at the time of infection. abstract: Cancer patients are at particular risk from COVID-19 since they usually present multiple risk factors for this infection such as older age, immunosuppressed state, comorbidities (e.g., chronic lung disease, diabetes, cardiovascular diseases), need of frequent hospital admissions and visits. Therefore, in the COVID era, oncologists should carefully weigh risks/benefits when planning cancer therapies and follow-up appointments. Recently, several scientific associations developed specific guidelines or recommendations to help physicians in their clinical practice. This review focuses on main available guidelines/recommendations regarding the cancer patient management during the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32767203/ doi: 10.1007/s12032-020-01406-5 id: cord-033574-4y53ryoa author: Tashiro, Hiroki title: Biomarkers for Overweight in Adult-Onset Asthma date: 2020-10-02 words: 2693.0 sentences: 140.0 pages: flesch: 53.0 cache: ./cache/cord-033574-4y53ryoa.txt txt: ./txt/cord-033574-4y53ryoa.txt summary: On serum cytokine and chemokine analyses, the overweight asthma group included significantly more patients with a lower level of tissue growth factor α (TGF-α) (1.1 pg/mL) and higher levels of hsIL-6 (2.5 pg/mL), RANTES/CCL5 (298.5 pg/mL), and vascular endothelial growth factor A (VEGF-A) (63.7 pg/mL), than the non-overweight asthma group (p=0.02, p<0.01, p=0.02, p=0.01, respectively). CONCLUSION: The present study showed that overweight patients with adult-onset asthma were characterized by a higher rate of annual exacerbations and worse lung function despite treatment with high-dose inhaled corticosteroids and lower blood eosinophil counts than non-overweight patients with asthma. 7 Thus, the present study focused only on adult-onset asthma and showed that blood eosinophil counts were significantly lower in overweight patients with asthma than in non-overweight patients with asthma (Table 1) , and they were negatively correlated with BMI (Figure 1 ), consistent with low type 2 inflammation, as described in previous reports. abstract: PURPOSE: Overweight and obesity are associated with one of the severe phenotypes of asthma, with an increased rate of exacerbations, low level of lung function, and reduced response to corticosteroid therapy. The present study focused on identifying useful biomarkers of severity in overweight patients with adult-onset asthma using real-world data. PATIENTS AND METHODS: A total of 56 patients with adult-onset asthma who visited Saga University Hospital between 2018 and 2019 were retrospectively reviewed. Overweight was defined as a body mass index (BMI) greater than 25 kg/m(2). Blood eosinophils, cytokines, and chemokines were compared between non-overweight asthma and overweight asthma patients. RESULTS: Overweight asthma patients had a higher annual exacerbation rate, lower pulmonary function even when treated frequently with high-dose inhaled corticosteroids, and a significantly lower percentage of eosinophils and lower eosinophil count compared to non-overweight asthma patients (p<0.01, p=0.03). Moreover, the percentage of eosinophils was significantly negatively correlated with BMI (ρ=−0.38, p<0.01) (Figure 1). On serum cytokine and chemokine analyses, the overweight asthma group included significantly more patients with a lower level of tissue growth factor α (TGF-α) (1.1 pg/mL) and higher levels of hsIL-6 (2.5 pg/mL), RANTES/CCL5 (298.5 pg/mL), and vascular endothelial growth factor A (VEGF-A) (63.7 pg/mL), than the non-overweight asthma group (p=0.02, p<0.01, p=0.02, p=0.01, respectively). CONCLUSION: The present study showed that overweight patients with adult-onset asthma were characterized by a higher rate of annual exacerbations and worse lung function despite treatment with high-dose inhaled corticosteroids and lower blood eosinophil counts than non-overweight patients with asthma. On blood cytokine and chemokine analyses, a low level of TGF-α and high levels of hsIL-6, RANTES/CCL5, and VEGF-A might be biomarkers reflecting the pathophysiology in overweight patients with asthma. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537834/ doi: 10.2147/jaa.s276371 id: cord-331165-2yn1n3eq author: Tauben, David J. title: Optimizing telehealth pain care after COVID-19 date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1097/j.pain.0000000000002048 doi: 10.1097/j.pain.0000000000002048 id: cord-339267-p3djwg7v author: Taylor, Sally title: Exploring the experiences of patients, general practitioners and oncologists of prostate cancer follow-up: A qualitative interview study date: 2020-08-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To examine the experiences of patients and healthcare professionals of prostate cancer follow-up in primary care and to identify areas where current policy and practice could be improved. METHODS: Semi-structured interviews with patients, GPs and oncologists explored experiences of prostate cancer follow-up. Interviews were audio recorded and transcribed verbatim. Data were analysed using thematic analysis. The three participant groups were analysed as individual datasets but the same key themes were evident across the groups. RESULTS: 14 patients, 6 GPs and 5 oncologists were interviewed. Four main themes were identified: Experience of current practice; Knowledge and understanding of prostate cancer follow up; Disparity of processes and pathways; Unclear roles and responsibilities. CONCLUSIONS: Findings from this study highlight the variation in the approach to prostate specific antigen monitoring and emphasise the lack of clear policies and practices. The lack of clarity around existing follow up and monitoring processes could cause delays in the diagnosis of recurrence. There is a need for a new and improved pathway for prostate cancer follow up. The pathway should include clear and concise guidance for patients, primary care and secondary care and all relevant parties need to understand what their role is within the pathway. url: https://www.sciencedirect.com/science/article/pii/S1462388920301009?v=s5 doi: 10.1016/j.ejon.2020.101820 id: cord-289816-rlwoy8ms author: Tedeschi, Delio title: Acute myocardial infarction and large coronary thrombosis in a patient with COVID‐19 date: 2020-08-07 words: 1450.0 sentences: 74.0 pages: flesch: 41.0 cache: ./cache/cord-289816-rlwoy8ms.txt txt: ./txt/cord-289816-rlwoy8ms.txt summary: This is a case report of a 60‐year‐old male, without any cardiovascular risk factor and no cardiac history admitted to hospital with a diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID‐19). Due to high levels of proinflammatory mediators, diffuse coronary thrombosis could occur even in patients without cardiac history or comorbidities. This clinical case suggests that coronary thrombosis in COVID‐19 patients may be unresponsive to optimal pharmacological (GP IIb–IIIa infusion) and mechanical treatment (PCI). The chest X-ray revealed evidence of pneumonia with bilateral multiple interstitial ill-defined patchy opacities ( When admitted, the patient was treated with dexamethasone (12 mg iv), hydroxychloroquine (200 mg twice daily), antiviral drugs (lopinavir/ritonavir-2 tablets 200/50 mg twice daily), oxygen support (Venturi mask FiO2 40%), antibiotic prophylaxis with ceftriaxone (2 g iv), and venous thromboembolic (VTE) prophylaxis with enoxaparin (4,000 U.I. sc). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China abstract: This is a case report of a 60‐year‐old male, without any cardiovascular risk factor and no cardiac history admitted to hospital with a diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID‐19). After 7 days, the blood tests showed a significant rise of inflammatory and procoagulant markers, along with a relevant elevation of high‐sensitivity Troponin I. Electrocardiogram and transthoracic echocardiogram (TTE) were consistent with a diagnosis of infero‐posterolateral acute myocardial infarction and the patient was transferred to the isolated Cath Lab for primary percutaneous coronary intervention (PCI). The angiography showed an acute massive thrombosis of a dominant right coronary artery without clear evidence of atherosclerosis. Despite the optimal pharmacological therapies and different PCI techniques, the final TIMI flow was 0/1 and after 3 hr the clinical condition evolved in cardiac arrest for pulseless electric activity. Acute coronary syndrome–ST‐elevation myocardial infarction is a relevant complication of COVID‐19. Due to high levels of proinflammatory mediators, diffuse coronary thrombosis could occur even in patients without cardiac history or comorbidities. This clinical case suggests that coronary thrombosis in COVID‐19 patients may be unresponsive to optimal pharmacological (GP IIb–IIIa infusion) and mechanical treatment (PCI). url: https://doi.org/10.1002/ccd.29179 doi: 10.1002/ccd.29179 id: cord-301087-9vl5pqi7 author: Teh, Benjamin W. title: Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital date: 2014-12-10 words: 2634.0 sentences: 147.0 pages: flesch: 41.0 cache: ./cache/cord-301087-9vl5pqi7.txt txt: ./txt/cord-301087-9vl5pqi7.txt summary: The epidemiology, risk factors and outcomes of viral respiratory tract infections (vRTI) are not well described in patients with multiple myeloma managed with novel agents, the current standard of care. Whilst the epidemiology, clinical outcomes and risk factors associated with viral RTI (vRTI) are well known in the haematopoietic stem cell transplant (HSCT) setting and supported by appropriate management guidelines, these characteristics have not been reported in myeloma patients managed with novel agents [5, 6] . Patients were identified retrospectively from chemotherapy drug dispensing and microbiology databases using the following criteria: a confirmed diagnosis of multiple myeloma, received active therapy with IMiD or PI and tested positive for respiratory viral (RV) infection by nucleic acid amplification testing (NAT) at Peter MacCallum Cancer Centre (PMCC) from January 2009 to December 2012. Clinical records of eligible patients were reviewed using a standardized tool to capture the following: patient demographics, myeloma therapy, seasonality of infection, radiological changes, clinical features and outcomes (length of stay (LOS)), requirement for intensive care (ICU) management and all-cause mortality at 30 days). abstract: INTRODUCTION: Infections are a leading cause of morbidity and mortality in patients with multiple myeloma. The epidemiology, risk factors and outcomes of viral respiratory tract infections (vRTI) are not well described in patients with multiple myeloma managed with novel agents, the current standard of care. METHODS: Patients with myeloma from 2009 to 2012 who tested positive on respiratory virus multiplex polymerase chain reaction had clinical, radiological and microbiological records reviewed. The Fourth European Conference on Infections in Leukaemia (ECIL-4) definitions of RTI were applied. Univariate and multivariate regression analysis of risk factors was performed using vRTI as the evaluable outcome. RESULTS: Of 330 patients, 75 (22.7 %) tested positive for a total of 100 vRTI episodes. All patients received thalidomide, lenalidomide or bortezomib in combination with myeloma therapies (median of three treatment regimens). vRTI occurred most commonly in patients with progressive disease, and receipt of more than three lines of myeloma therapy was associated with an increased risk of vRTI (p < 0.01). Amongst key respiratory pathogens, influenza was associated with the highest hospital admission rate (66.7 %), ICU admission rate (41.6 %) and mortality (33.3 %) whilst RSV was associated with prolonged hospital stay. CONCLUSION: Patients with multiple myeloma and advanced disease managed with multiple lines of therapy are at risk for vRTI, and targeted interventions for prevention/treatment are required. url: https://www.ncbi.nlm.nih.gov/pubmed/25487843/ doi: 10.1007/s00520-014-2550-3 id: cord-301521-mpm43aga author: Teixeira, Andre Luiz Schuh title: La urgencia de implementar y ampliar la telepsiquiatría durante la crisis de COVID-19: perspectiva de los psiquiatras que inician su carrera date: 2020-06-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1016/j.rpsm.2020.06.001 doi: 10.1016/j.rpsm.2020.06.001 id: cord-267020-4mpc246u author: Teixeira, Cassiano title: The medical decision-making process in the time of the coronavirus pandemic date: 2020 words: 2299.0 sentences: 142.0 pages: flesch: 45.0 cache: ./cache/cord-267020-4mpc246u.txt txt: ./txt/cord-267020-4mpc246u.txt summary: In this context, we must prevent intuitive decision-making and insecurity from leading us to exhaust the available critical-care beds before they are truly necessary, while still recognizing the importance of rapid decision-making in emergency situations. The disease pandemic caused by the novel coronavirus has triggered significant changes in the medical decision-making process relating to critically ill patients. The disease pandemic caused by the novel coronavirus has triggered significant changes in the medical decision-making process relating to critically ill patients. The disease pandemic caused by the novel coronavirus has triggered significant changes in the medical decision-making process relating to critically ill patients. (2) (3) (4) More experienced doctors use intuitive and automatic cognitive processing -the infamous "clinical eye." Basically, this system relies on heuristics (mental shortcuts) to assess to what extent the patient''s symptoms fit the patterns and prototypes of diseases that professionals have stored in their memory. abstract: The disease pandemic caused by the novel coronavirus has triggered significant changes in the medical decision-making process relating to critically ill patients. Admissions to intensive care units have suddenly increased, but many of these patients do not present with clinical manifestations related to the viral infection but rather exacerbation of preexisting diseases. In this context, we must prevent intuitive decision-making and insecurity from leading us to exhaust the available critical-care beds before they are truly necessary, while still recognizing the importance of rapid decision-making in emergency situations. One of the best ways to achieve this goal may be by practicing metacognition and establishing ways for regular feedback to be provided to professionals engaged in inherently rapid decision-making processes. url: https://www.ncbi.nlm.nih.gov/pubmed/32667435/ doi: 10.5935/0103-507x.20200033 id: cord-010416-u0yo0lk6 author: Tejada, Sofia title: Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials date: 2020-04-28 words: 4008.0 sentences: 207.0 pages: flesch: 38.0 cache: ./cache/cord-010416-u0yo0lk6.txt txt: ./txt/cord-010416-u0yo0lk6.txt summary: A systematic review of randomized controlled trials (RCTs) was conducted to evaluate the efficacy and safety of alternative neuraminidase inhibitor (NAI) regimens compared to standard of care in patients hospitalized for H1N1, H3N2, or B influenza. Thus, the study''s aim was to perform a systematic review (SR) of randomized controlled trials (RCT) to evaluate the efficacy and safety of alternative NAI regimens compared with 75 mg orally administered oseltamivir twice/daily or 600 mg intravenously administered peramivir once/daily in patients hospitalized for H1N1, H3N2, or B influenza. The evidence evaluated in this SR indicates that the alternative NAI regimens to orally administered oseltamivir 75 mg twice/daily or intravenously administered peramivir 600 mg once/daily to treat hospitalized patients with influenza infection are equally safe but do not modify meaningful clinical outcomes when compared with the standard dose. abstract: INTRODUCTION: Influenza in hospitalized intensive care unit (ICU) patients with respiratory failure is associated with 25% mortality, despite timely oseltamivir treatment. A systematic review of randomized controlled trials (RCTs) was conducted to evaluate the efficacy and safety of alternative neuraminidase inhibitor (NAI) regimens compared to standard of care in patients hospitalized for H1N1, H3N2, or B influenza. METHODS: The Cochrane collaboration searching methods were followed in Cochrane Library, PubMed, and Web of Science databases (2009–2019). Eligibility criteria were RCTs comparing different regimens of NAIs in hospitalized patients (at least 1 year old) for clinically diagnosed influenza (H1N1, H3N2, or B). Pre-defined endpoints were time to clinical resolution (TTCR), overall mortality, hospital discharge, viral clearance, drug-related adverse events (AEs), and serious adverse events. RESULTS: Seven trials (1579 patients) were included. Two trials compared two regimens of oral oseltamivir therapy, and one trial compared two regimens of intravenous zanamivir therapy vs oral oseltamivir therapy. Four trials focused on intravenous peramivir therapy: two trials compared two different regimens and two trials compared two different regimens vs oral oseltamivir therapy. Overall, the different regimens were well tolerated, with no significant differences in AEs; nonetheless non-significant differences were reported among different regimens regarding TTCR, mortality, and viral clearance. CONCLUSION: Higher compared to standard doses of NAIs or systemic peramivir therapy compared to oral oseltamivir therapy did not demonstrate benefit. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12325-020-01347-5) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187665/ doi: 10.1007/s12325-020-01347-5 id: cord-010261-sy7esszi author: Tenenbein, Milton title: Early coagulopathy in severe iron poisoning date: 2006-08-17 words: 1333.0 sentences: 92.0 pages: flesch: 49.0 cache: ./cache/cord-010261-sy7esszi.txt txt: ./txt/cord-010261-sy7esszi.txt summary: Our observations suppol:t the presence of an early, reversible coagulopathy dependent on the serum iron concentration in poisoned patients. Its onset is usually delayed for at least 24 hours after iron ingestion, making the early coagulation abnormalities in patients 1 and 2 noteworthy. The coagulation measurements in patient 1 also improved coincident with a precipitous fall in serum iron concentration and prior to the onset of the hepatic coagulopathy. The initial ~hase, occurring within hours of overdose, appears to be a functional, reversible, and serum iron concentration-dependent impairment of coagulation. 6 If additional experience confirms the presence of an early coagulopathy in severe iron poisoning, the presence of early coagulation abnormalities could also suggest the need for deferoxamine therapy. Identification of respiratory virus antigens in middle ear fluids of children with acute otitis media abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173231/ doi: 10.1016/s0022-3476(88)80381-0 id: cord-313082-n3bo9jw1 author: Tenenbein, Paul title: The case for routine screening for SARS-CoV-2 before surgery date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32495121/ doi: 10.1007/s12630-020-01730-4 id: cord-289719-64ugdvfe author: Tenforde, Mark W. title: Characteristics of Adult Outpatients and Inpatients with COVID-19 — 11 Academic Medical Centers, United States, March–May 2020 date: 2020-07-03 words: 3166.0 sentences: 148.0 pages: flesch: 46.0 cache: ./cache/cord-289719-64ugdvfe.txt txt: ./txt/cord-289719-64ugdvfe.txt summary: During April 15-May 24, 2020, telephone interviews were conducted with a random sample of adults aged ≥18 years who had positive reverse transcription-polymerase chain reaction (RT-PCR) test results for SARS-CoV-2 in outpatient and inpatient settings at 11 U.S. academic medical centers in nine states. During April 15-May 24, 2020, telephone interviews were conducted with a random sample of adults aged ≥18 years who had positive reverse transcription-polymerase chain reaction (RT-PCR) test results for SARS-CoV-2 in outpatient and inpatient settings at 11 U.S. academic medical centers in nine states. To explore the spectrum of illness across health care settings and potential community SARS-CoV-2 exposures after issuance of national social distancing guidelines on March 16, 2020 (4), 11 academic medical centers in nine states conducted telephone-based surveys of a sample of patients with positive SARS-COV-2 test results during April 15-May 24, 2020 (testing dates = March 31-May 10, 2020). abstract: Descriptions of coronavirus disease 2019 (COVID-19) in the United States have focused primarily on hospitalized patients. Reports documenting exposures to SARS-CoV-2, the virus that causes COVID-19, have generally been described within congregate settings, such as meat and poultry processing plants (1) and long-term care facilities (2). Understanding individual behaviors and demographic characteristics of patients with COVID-19 and risks for severe illness requiring hospitalization can inform efforts to reduce transmission. During April 15-May 24, 2020, telephone interviews were conducted with a random sample of adults aged ≥18 years who had positive reverse transcription-polymerase chain reaction (RT-PCR) test results for SARS-CoV-2 in outpatient and inpatient settings at 11 U.S. academic medical centers in nine states. Respondents were contacted 14-21 days after SARS-CoV-2 testing and asked about their demographic characteristics, underlying chronic conditions, symptoms experienced on the date of testing, and potential exposures to SARS-CoV-2 during the 2 weeks before illness onset (or the date of testing among those who did not report symptoms at the time of testing). Among 350 interviewed patients (271 [77%] outpatients and 79 [23%] inpatients), inpatients were older, more likely to be Hispanic and to report dyspnea than outpatients. Fewer inpatients (39%, 20 of 51) reported a return to baseline level of health at 14-21 days than did outpatients (64%, 150 of 233) (p = 0.001). Overall, approximately one half (46%) of patients reported known close contact with someone with COVID-19 during the preceding 2 weeks. This was most commonly a family member (45%) or a work colleague (34%). Approximately two thirds (64%, 212 of 333) of participants were employed; only 35 of 209 (17%) were able to telework. These findings highlight the need for screening, case investigation, contact tracing, and isolation of infected persons to control transmission of SARS-CoV-2 infection during periods of community transmission. The need for enhanced measures to ensure workplace safety, including ensuring social distancing and more widespread use of cloth face coverings, are warranted (3). url: https://doi.org/10.15585/mmwr.mm6926e3 doi: 10.15585/mmwr.mm6926e3 id: cord-298034-0ntxm28a author: Tepper, Joel E. title: Ethical Issues in Radiation Oncology During a Pandemic date: 2020-05-22 words: 1416.0 sentences: 75.0 pages: flesch: 53.0 cache: ./cache/cord-298034-0ntxm28a.txt txt: ./txt/cord-298034-0ntxm28a.txt summary: Medicine in the United States has generally followed ethical principles espoused by Immanuel Kant where the individual patient takes priority in decision-making. With the advent of coronavirus disease 2019 as a major health event, radiation oncologists in some situations need to alter the manner in which they act with individual patients. The longstanding general ethical principles followed in the United States are based largely on concepts elucidated by Immanuel Kant and emphasize individual autonomy. Our US radiation oncology community fortunately rarely faces such emergency situations, but the present COVID-19 pandemic is forcing us to address serious ethical issues. We need to consider not just the impact of radiation therapy on that patient, but also the impact on other patients, health care workers, and society at large. Much cancer treatment is multi-modality, combining radiation therapy with surgery, chemotherapy, and/or immunotherapy, but it may be appropriate to alter standard sequencing in some situations. abstract: Medicine in the United States has generally followed ethical principles espoused by Immanuel Kant where the individual patient takes priority in decision-making. With the advent of coronavirus disease 2019 as a major health event, radiation oncologists in some situations need to alter the manner in which they act with individual patients. The well-being of health care workers and society as a whole needs to be considered in management decisions. During the time of a pandemic, ethics principles may be based more on a utilitarian approach that emphasizes the common good. Thus, at times treatment decisions might result in delays in initiating therapy, modifying the radiation treatment course (such as to a short course rather than a long course of therapy), and the sequence of therapies, all to minimize viral exposure. It is important that altered therapy is based as much as possible on institutional or departmental decisions and, to the extent possible, not on a case-by-case basis. However, in all situations, we need to still respect the individual's autonomy and fully inform patients of our decisions and the reasons for those decisions. url: https://www.sciencedirect.com/science/article/pii/S2452109420301366?v=s5 doi: 10.1016/j.adro.2020.04.037 id: cord-345680-10phij1x author: Terpos, Evangelos title: Hematological findings and complications of COVID‐19 date: 2020-05-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID‐19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Lymphopenia may be considered as a cardinal laboratory finding, with prognostic potential. Neutrophil/lymphocyte ratio and peak platelet/lymphocyte ratio may also have prognostic value in determining severe cases. During the disease course, longitudinal evaluation of lymphocyte count dynamics and inflammatory indices, including LDH, CRP and IL‐6 may help to identify cases with dismal prognosis and prompt intervention in order to improve outcomes. Biomarkers, such high serum procalcitonin and ferritin have also emerged as poor prognostic factors. Furthermore, blood hypercoagulability is common among hospitalized COVID‐19 patients. Elevated D‐Dimer levels are consistently reported, whereas their gradual increase during disease course is particularly associated with disease worsening. Other coagulation abnormalities such as PT and aPTT prolongation, fibrin degradation products increase, with severe thrombocytopenia lead to life‐threatening disseminated intravascular coagulation (DIC), which necessitates continuous vigilance and prompt intervention. So, COVID‐19 infected patients, whether hospitalized or ambulatory, are at high risk for venous thromboembolism, and an early and prolonged pharmacological thromboprophylaxis with low molecular weight heparin is highly recommended. Last but not least, the need for assuring blood donations during the pandemic is also highlighted. url: https://doi.org/10.1002/ajh.25829 doi: 10.1002/ajh.25829 id: cord-279846-g0ro8pbb author: Terrigno, Vittorio R title: Right Atrial Thrombus in a Patient With COVID-19 date: 2020-07-28 words: 1056.0 sentences: 65.0 pages: flesch: 47.0 cache: ./cache/cord-279846-g0ro8pbb.txt txt: ./txt/cord-279846-g0ro8pbb.txt summary: We highlight the successful use of half-dose anticoagulation in the treatment of right atrial thrombus in a patient with COVID-19. To our knowledge, this is a first reported case of right atrial thrombus in a COVID-19 patient who was treated successfully with half-dose anticoagulation. In another three-center retrospective study of 184 COVID-19 ICU patients from the Netherlands, the authors reported 31% incidence of thrombotic complications. Therefore, the true incidence is likely higher.Our case supports the need to think of initiating therapeutic anticoagulation early in the course of critically ill patients with COVID-19. In addition to this, our case also highlights the use of half-dose anticoagulation therapy to treat a right atrial thrombus. To our knowledge, this is the first reported case of right atrial thrombus in a COVID-19 patient that resolved with a half dose of thrombolytic therapy. We highlight the ability to treat a right atrial thrombus in a patient with COVID-19 with half-dose anticoagulation. abstract: Coronavirus disease 2019 (COVID-19) is a worldwide pandemic. Evidence suggests a strong association between COVID-19 and pro-thrombotic states. We report our experience in managing a patient with COVID-19 complicated by a right atrial thrombus. We highlight the successful use of half-dose anticoagulation in the treatment of right atrial thrombus in a patient with COVID-19. To our knowledge, this is a first reported case of right atrial thrombus in a COVID-19 patient who was treated successfully with half-dose anticoagulation. url: https://www.ncbi.nlm.nih.gov/pubmed/32864265/ doi: 10.7759/cureus.9441 id: cord-278547-y0hvq0qf author: Testori, Alberto title: Extraordinary emergency measures set up by a Breast Unit to prevent COVID‐19: Report of our experience date: 2020-06-25 words: 686.0 sentences: 47.0 pages: flesch: 52.0 cache: ./cache/cord-278547-y0hvq0qf.txt txt: ./txt/cord-278547-y0hvq0qf.txt summary: These measures are also justified by data, suggesting patients with cancer are more susceptible to infection and respiratory complications related to COVID-19 compared to those without cancer, due to immunosuppressive state caused by malignancy and chemotherapy. If reconstruction was needed, patient was admitted on the same day of surgery in a dedicated ward and discharged the day after. In case of patient with COVID-19 and no possibility to postpone surgery, a dedicated surgical theater and ward was available. A recent paper showed a slight prevalence of male patient with diagnosis of COVID-19 and a higher fatality rate (2.8%) when compared to female (1.7%). Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) -China abstract: nan url: https://doi.org/10.1111/tbj.13920 doi: 10.1111/tbj.13920 id: cord-293704-tnik6sd3 author: Tey, Jeremy title: Navigating the challenges of the COVID-19 outbreak: perspectives from the radiation oncology service in singapore date: 2020-03-31 words: 3512.0 sentences: 220.0 pages: flesch: 51.0 cache: ./cache/cord-293704-tnik6sd3.txt txt: ./txt/cord-293704-tnik6sd3.txt summary: There is a higher risk of mortality of COVID-19 in cancer patients and hence unique considerations for a radiation oncology department operating in an infectious disease outbreak. There is a higher risk of mortality of COVID-19 in cancer patients and hence unique considerations for a radiation oncology department operating in an infectious disease outbreak. This includes interventions, business continuity plans and workflow in managing a COVID-19 positive patient on radiotherapy. With the evolving COVID-19 outbreak, there needs to be provisions and policies to ensure continuity of radiation oncology services. There should be provisions within the department such that continuity of radiation oncology services will not be impacted as there is possibility of staff managing confirmed cases and therefore needs to be self-quarantined at home. Nonetheless, radiation oncology departments can act to better position themselves to continue radiotherapy services in the face of resource limitations brought on by the outbreak, as well as to protect staff and patients. abstract: In December 2019, pneumonia of unknown cause was reported by China to WHO. The outbreak was found to be caused by a coronavirus which was officially named “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), and the disease caused by it was named ‘COVID-19’. The first case in Singapore was confirmed on 23(rd) January 2020. With lessons learnt from the SARS epidemic in 2003 and the H1N1 flu pandemic in 2009, Singapore was much better prepared to deal with the virus outbreak. The government has taken swift measures to contain and break the chain of transmission. Healthcare workers face the challenge of keeping patients and staff safe from the disease. There is a higher risk of mortality of COVID-19 in cancer patients and hence unique considerations for a radiation oncology department operating in an infectious disease outbreak. This article is the recommendations and adapted workflow from the two National Cancer Centres in Singapore with the endorsement by the working committee of the Chapter of Radiation Oncology, Academy of Medicine, Singapore. It highlights the challenges that radiation oncology departments in Singapore face and the appropriate recommended responses. This includes interventions, business continuity plans and workflow in managing a COVID-19 positive patient on radiotherapy. url: https://www.sciencedirect.com/science/article/pii/S016781402030164X?v=s5 doi: 10.1016/j.radonc.2020.03.030 id: cord-302756-343y63e5 author: Thachil, J title: Understanding the COVID‐19 coagulopathy spectrum date: 2020-05-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The SARS‐Cov‐2 (COVID‐19) pandemic has already claimed over 200,000 lives. Quite early on in this pandemic, it was recognised that the virus triggers the immune system leading to a cytokine storm in some severely ill patients [1]. This hyper‐responsiveness has been suggested to be the predominant aetiology for clinical deterioration and mortality in patients with this infection [2]. More recently, there have been several reports of increased thrombotic events in these patients [3‐6]. From a laboratory perspective, this hypercoagulability is reflected in the marked elevation of the fibrinolytic marker, D‐dimer, in almost all hospitalised COVID‐19 patients [7]. We must, therefore, ask ourselves what is the link between the extremes of the immune system, presenting as cytokine storm, and the extremes of coagulation, presenting as arterial and venous thromboembolism? url: https://doi.org/10.1111/anae.15141 doi: 10.1111/anae.15141 id: cord-023168-cd7adns8 author: Thachil, Jecko title: Haematological Diseases in the Tropics date: 2013-10-21 words: 30224.0 sentences: 1724.0 pages: flesch: 44.0 cache: ./cache/cord-023168-cd7adns8.txt txt: ./txt/cord-023168-cd7adns8.txt summary: The most useful laboratory measure of iron status Low value is diagnostic in the presence of anaemia Very high values (>100 µg/L) usually exclude iron deficiency'' Being an acute-phase protein, it increases in inflammatory conditions, and certain malignancies, making it unreliable Also increased in tissue damage especially of the liver Levels are falsely decreased in vitamin C deficiency and hypothyroidism Erythrocyte zinc protoporphyrin An intermediate in haem biosynthesis and elevated concentrations indicate interrupted haem synthesis due to iron deficiency when zinc is incorporated in place of iron Can be measured on a drop of blood with a portable haematofluorometer Small sample size makes it very useful as a screening test in field surveys, particularly in children, and pregnant women where inflammatory states may not co-exist Red cells should be washed before measurement (serum bilirubin and fluorescent compounds like some drugs can give falsely high values) although not often done Lead poisoning can give falsely high values Rarely acute myeloid leukaemia and sideroblastic anaemia give slightly high values Useful in that it is not increased in thalassaemias WHO recommends normal level >70 µmol/mol haem Iron studies Serum iron concentration represents the iron entering and leaving the circulation. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167525/ doi: 10.1016/b978-0-7020-5101-2.00066-2 id: cord-339589-dl2qpc0t author: Thachil, Jecko title: SARS-2 Coronavirus–Associated Hemostatic Lung Abnormality in COVID-19: Is It Pulmonary Thrombosis or Pulmonary Embolism? date: 2020-05-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1055/s-0040-1712155 doi: 10.1055/s-0040-1712155 id: cord-351597-bdazrbsz author: Thalappillil, Richard title: POCUS to guide fluid-therapy in COVID-19 date: 2020-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1053077020304080?v=s5 doi: 10.1053/j.jvca.2020.04.049 id: cord-329582-y4gyw8vz author: Tham, Hui-Yu title: Is There Still a Role for Physical Consultation in Colorectal Cancer Surveillance? date: 2020-08-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32865732/ doi: 10.1007/s11605-020-04774-5 id: cord-277323-jqr2hkv2 author: Thampi, Swapna title: Considerations for resuscitation and transfer of paediatric patients with COVID-19 date: 2020-04-27 words: 261.0 sentences: 27.0 pages: flesch: 48.0 cache: ./cache/cord-277323-jqr2hkv2.txt txt: ./txt/cord-277323-jqr2hkv2.txt summary: key: cord-277323-jqr2hkv2 authors: Thampi, Swapna; Melvin Lee, Chang Chuan; Zhi Ng, Beatrice Hui; Anne Yap, Andrea Pek title: Considerations for resuscitation and transfer of paediatric patients with COVID-19 cord_uid: jqr2hkv2 Swapna Thampi 1* , Chang Chuan Melvin Lee 1 with severe and critical disease being more prevalent in younger children. 6 As the pandemic spreads, we will encounter more paediatric patients with COVID-19 disease who require resuscitation and transfer. A Novel Coronavirus from Patients with Pneumonia in China Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0007091220302786?v=s5 doi: 10.1016/j.bja.2020.04.063 id: cord-289115-bntcn0m6 author: Thangaraju, Pugazhenthan title: Role of Dupilumab in Approved Indications of COVID-19 Patient: an Efficacy-Based Nonsystematic Critical Analysis date: 2020-09-10 words: 2136.0 sentences: 110.0 pages: flesch: 49.0 cache: ./cache/cord-289115-bntcn0m6.txt txt: ./txt/cord-289115-bntcn0m6.txt summary: There are isolated case reports and series that document a milder course of COVID-19 infection in patients who have already been on dupilumab therapy for treatment of conditions such as atopic dermatitis and chronic rhino-sinusitis with nasal polyp. While it has already been in use in dermatology clinics for the treatment of atopic dermatitis (AD), it was most recently approved for the indication of chronic rhinosinusitis with nasal polyp (CRSwNP) by the US Food and Drug Association (FDA) on the 26th of June, 2019 [1] . We included clinical trials, research studies, case reports, and randomized control trials that employed the use of dupilumab at any point in the treatment of patients who were laboratory confirmed cases of COVID19. Details that were extracted included author and journal details, year of publication, sample size, age, sex, indication for rational use of dupilumab, duration for treatment, adverse effects observed, and course of COVID-19 infection. COVID-19 infection in a patient with severe chronic rhinosinusitis with nasal polyps during therapy with dupilumab abstract: With many drugs being tried in the management and treatment of COVID-19, dupilumab is one such monoclonal antibody that has come under the limelight for its possible role as an adjunct therapy in COVID-19 position. There are isolated case reports and series that document a milder course of COVID-19 infection in patients who have already been on dupilumab therapy for treatment of conditions such as atopic dermatitis and chronic rhino-sinusitis with nasal polyp. There is also an ongoing debate regarding the continuation of biologicals in the COVID patient. In this article, a non-systematic critical analysis of dupilumab was performed to delve into this hypothesis further. url: https://www.ncbi.nlm.nih.gov/pubmed/32935079/ doi: 10.1007/s42399-020-00510-x id: cord-340415-6fte7krp author: Thevarajan, Irani title: Clinical presentation and management of COVID‐19 date: 2020-07-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The rapid spread of severe acute respiratory syndrome coronavirus 2 led to the declaration of a global pandemic within 3 months of its emergence. The majority of patients presenting with coronavirus disease 2019 (COVID‐19) experience a mild illness that can usually be managed in the community. Patients require careful monitoring and early referral to hospital if any signs of clinical deterioration occur. Increased age and the presence of comorbidities are associated with more severe disease and poorer outcomes. Treatment for COVID‐19 is currently predominantly supportive care, focused on appropriate management of respiratory dysfunction. Clinical evidence is emerging for some specific therapies (including antiviral and immune‐modulating agents). Investigational therapies for COVID‐19 should be used in the context of approved randomised controlled trials. Australian clinicians need to be able to recognise, diagnose, manage and appropriately refer patients affected by COVID‐19, with thousands of cases likely to present over the coming years. url: https://www.ncbi.nlm.nih.gov/pubmed/32677734/ doi: 10.5694/mja2.50698 id: cord-343201-98scxky8 author: Thibault, Ronan title: How the Covid-19 epidemic is challenging our practice in clinical nutrition—feedback from the field date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The viral epidemic caused by the new Coronavirus SARS-CoV-2 is responsible for the new Coronavirus disease-2019 (Covid-19). Fifteen percent of the Covid-19 patients will require hospital stay, and 10% of them will need urgent respiratory and hemodynamic support in the intensive care unit (ICU). Covid-19 is an infectious disease characterized by inflammatory syndrome, itself leading to reduced food intake and increased muscle catabolism. Therefore Covid-19 patients are at high risk of being malnourished, making the prevention of malnutrition and the nutritional management key aspects of care. Urgent, brutal and massive arrivals of patients needing urgent respiratory care and artificial ventilation lead to the necessity to reorganize hospital care, wards and staff. In that context, nutritional screening and care may not be considered a priority. Moreover, at the start of the epidemic, due to mask and other protecting material shortage, the risk of healthcare givers contamination have led to not using enteral nutrition, although indicated, because nasogastric tube insertion is an aerosol-generating procedure. Clinical nutrition practice based on the international guidelines should therefore adapt and the use of degraded procedures could unfortunately be the only way. Based on the experience from the first weeks of the epidemic in France, we emphasize ten challenges for clinical nutrition practice. The objective is to bring objective answers to the most frequently met issues to help the clinical nutrition caregivers to promote nutritional care in the hospitalized Covid-19 patient. We propose a flow chart for optimizing the nutrition management of the Covid-19 patients in the non-ICU wards. url: https://doi.org/10.1038/s41430-020-00757-6 doi: 10.1038/s41430-020-00757-6 id: cord-320184-wacoz5t9 author: Thirumalaikolundusubramanian, Ponniah title: Ethics, Legality, and Education in the Practice of Cardiology date: 2014-08-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Advances in diagnostics, drugs, and devices have revolutionized cardiology practice, and improved quality of life of the patients. However, awareness, achievements, and advances in cardiac health care have enhanced the demands and expectations of the community, which lacks awareness about the social, economic, administrative, professional, and technical constraints or limitations of implementation. Being unfamiliar with medical ethics and legal aspects of care, and suboptimal virtues among physicians, have led to patients and the public utilizing legal remedies. In addition, sophistication of medical practice, increasing costs of health care, involvement of insurance systems, increased awareness and high expectations from the community and patients, and increased participation of the media have altered the attitude toward claiming compensation and acquisition of health care delivery among the public. In view of the changing trends of consumers and emerging areas in health care, providers must get accustomed to patient empowerment and come up to their expectations. Interactive programs on these aspects in medical education will help students understand not only the intricacies of medical ethics and the laws and shortcomings of health professionals and/or health systems, but also strengthen their knowledge of ethics and laws to improve their practice. Principles of ethics and legal issues have to be discussed at every stage of medical education. To improve the quality of the physician–patient encounter, we need to develop formal and informal curricula about effective communication skills. This chapter also highlights preventive measures and educational aspects of cardiology practice. url: https://www.sciencedirect.com/science/article/pii/B9780124165953000232 doi: 10.1016/b978-0-12-416595-3.00023-2 id: cord-336368-sudi4mdx author: Thiruvenkatarajan, Venkatesan title: High-flow nasal cannula versus standard oxygen therapy assisting sedation during endoscopic retrograde cholangiopancreatography in high risk cases (OTHER): study protocol of a randomised multicentric trial date: 2020-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is an increasingly common intervention in the treatment of pancreaticobiliary disorders. Patients are often elderly with complex co-morbidities. While monitored anaesthesia care with sedation is commonly used for most cases, few would require general anaesthesia with an endotracheal tube. Both low-flow and high-flow nasal cannulas (HFNC) are established ways of delivering supplemental oxygen, but it is unclear whether one technique is better than the other. HFNC seems a promising tool for advanced procedures but evidence to support its application in high-risk ERCP cases is limited. The rate of oxygen desaturation during endoscopy has been reported to be as high as 11%–50% and the method of oxygen delivery for ERCP merits further study. METHODS/DESIGN: This is a prospective, randomised, multicentre trial comparing the efficacy of oxygen supplementation through HFNC versus low-flow nasal cannula during ERCP, in a cohort of patients at risk of adverse respiratory events. A total of 132 patients will be recruited across three sites and randomly assigned to either the low-flow or the HFNC group. The primary outcome is the proportion of patients experiencing hypoxia, defined by any event of SpO2 < 90%. The secondary outcomes include parameters centred on oxygenation, requirement of airway manoeuvres, successful completion of procedure, perioperative complications, patient satisfaction and cost analysis of the consumables. An intention-to-treat principle will be applied while analysing. DISCUSSION: The demand for ERCPs is likely to increase in the future with the aging population. Our study results may lead to improved outcomes and reduce airway-related complications in patients undergoing ERCPs. The results will be presented at national and international meetings and published in peer-reviewed journals. TRIAL REGISTRATION: www.ANZCTR.org.au, CTRN12619000397112. Registered on 12 March 2019. url: https://www.ncbi.nlm.nih.gov/pubmed/32471494/ doi: 10.1186/s13063-020-04378-z id: cord-309323-yflng8m3 author: Thomas, T. title: COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status date: 2020-05-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Previous studies suggest a role for systemic reprogramming of host metabolism during viral pathogenesis to fuel rapidly expanding viral proliferation, for example by providing free amino acids and fatty acids as building blocks. In addition, general alterations in metabolism can provide key understanding of pathogenesis. However, little is known about the specific metabolic effects of SARS-COV-2 infection. The present study evaluated the serum metabolism of COVID-19 patients (n=33), identified by a positive nucleic acid test of a nasopharyngeal swab, as compared to COVID-19-negative control patients (n=16). Targeted and untargeted metabolomics analyses specifically identified alterations in the metabolism of tryptophan into the kynurenine pathway, which is well-known to be involved in regulating inflammation and immunity. Indeed, the observed changes in tryptophan metabolism correlated with serum interleukin-6 (IL-6) levels. Metabolomics analysis also confirmed widespread dysregulation of nitrogen metabolism in infected patients, with decreased circulating levels of most amino acids, except for tryptophan metabolites in the kynurenine pathway, and increased markers of oxidant stress (e.g., methionine sulfoxide, cystine), proteolysis, and kidney dysfunction (e.g., creatine, creatinine, polyamines). Increased circulating levels of glucose and free fatty acids were also observed, consistent with altered carbon homeostasis in COVID-19 patients. Metabolite levels in these pathways correlated with clinical laboratory markers of inflammation and disease severity (i.e., IL-6 and C-reactive protein) and renal function (i.e., blood urea nitrogen). In conclusion, this initial observational study of the metabolic consequences of COVID-19 infection in a clinical cohort identified amino acid metabolism (especially kynurenine and cysteine/taurine) and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets. url: https://doi.org/10.1101/2020.05.14.20102491 doi: 10.1101/2020.05.14.20102491 id: cord-345860-d02x3151 author: Thome, Johannes title: The impact of the COVID-19 outbreak on the medico-legal and human rights of psychiatric patients date: 2020-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has raised significant concerns for population mental health and the effective provision of mental health services in the light of increased demands and barriers to service delivery [1]. Particular attention is being directed toward the possible neuropsychiatric sequelae of both COVID-19 and of the stringent societal mitigation steps deployed by national governments, concerns that are informed by historical increases in the incidence of psychotic disorders following influenza pandemics [2]. However, so far there has been scant attention paid to other important areas of psychiatry during COVID-19, including medico-legal aspects and human rights. In this paper, we discuss the legal implications for psychiatry of the COVID-19 pandemic and report a novel situation in which psychiatric patients may experience diminution of their statutory protections. We believe that this represents a paradigm shift in psychiatric care and that the consideration of the fundamental rights of psychiatric patients as “less important” than infection control measures compel mental health professionals to “advocate for … patients and their caregivers” in this time of crisis [1]. url: https://www.ncbi.nlm.nih.gov/pubmed/32468988/ doi: 10.1192/j.eurpsy.2020.58 id: cord-003615-vpzzsdld author: Thompson, Kelly B. title: Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies date: 2019-04-24 words: 8886.0 sentences: 363.0 pages: flesch: 34.0 cache: ./cache/cord-003615-vpzzsdld.txt txt: ./txt/cord-003615-vpzzsdld.txt summary: Trauma leads to the dysregulation of both the innate and adaptive immune responses, which places the injured at risk for several late consequences, including delayed wound healing, late onset sepsis and infection, multi-organ dysfunction syndrome, and acute respiratory distress syndrome, which are significant for their association with the increased morbidity and mortality of wounded personnel. Patients with less severe trauma may develop late MODS due to new surgical stress, general anesthesia, transfusion of blood products, infection, or ischemia/reperfusion injury triggering the reactivation of the inflammatory response in a "two-hit" model of MODS [19, 58] . Among these consequences, delayed wound healing, late onset sepsis and infection, multi-organ dysfunction syndrome, acute respiratory distress syndrome, and persistent inflammation-immunosuppression and catabolic syndrome are significant in their association with the increased morbidity and mortality of wounded personnel. abstract: With improvements in personnel and vehicular body armor, robust casualty evacuation capabilities, and damage control resuscitation strategies, more combat casualties are surviving to reach higher levels of care throughout the casualty evacuation system. As such, medical centers are becoming more accustomed to managing the deleterious late consequences of combat trauma related to the dysregulation of the immune system. In this review, we aim to highlight these late consequences and identify areas for future research and therapeutic strategies. Trauma leads to the dysregulation of both the innate and adaptive immune responses, which places the injured at risk for several late consequences, including delayed wound healing, late onset sepsis and infection, multi-organ dysfunction syndrome, and acute respiratory distress syndrome, which are significant for their association with the increased morbidity and mortality of wounded personnel. The mechanisms by which these consequences develop are complex but include an imbalance of the immune system leading to robust inflammatory responses, triggered by the presence of damage-associated molecules and other immune-modifying agents following trauma. Treatment strategies to improve outcomes have been difficult to develop as the immunophenotype of injured personnel following trauma is variable, fluid and difficult to determine. As more information regarding the triggers that lead to immune dysfunction following trauma is elucidated, it may be possible to identify the immunophenotype of injured personnel and provide targeted treatments to reduce the late consequences of trauma, which are known to lead to significant morbidity and mortality. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480837/ doi: 10.1186/s40779-019-0202-0 id: cord-270665-z4l3lq39 author: Tian, Qing title: Endoscopic mask innovation and protective measures changes during the COVID‐19 pandemic: experience from a Chinese hepato‐biliary‐pancreatic unit date: 2020-07-23 words: 1833.0 sentences: 115.0 pages: flesch: 44.0 cache: ./cache/cord-270665-z4l3lq39.txt txt: ./txt/cord-270665-z4l3lq39.txt summary: However, due to the distinctive epidemiological characteristics of SARS‐CoV‐2 (the virus causing COVID‐19), healthcare providers are exposed to the patient''s respiratory and gastrointestinal fluids, rendering endoscopy a high risk for transmitting a nosocomial infection. This article introduces preventive measures for endoscopic treatment enacted in our medical center during COVID‐19, including the adjustment of indications, the application of endoscope protective equipment, the design and application of endoscopic masks and splash‐proof films, and novel recommendations for bedside endoscope pre‐sterilization. During the COVID-19 pandemic, due to the distinctive epidemiological characteristics of SARS-CoV-2, endoscopy poses a high risk of nosocomial infection, since healthcare providers are exposed to the patient''s respiratory and gastrointestinal fluids 6 . 6) All medical personnel who a) have fever or respiratory symptoms, b) had contact with suspected or confirmed COVID-19 patients, c) live in or had contact with individuals residing in areas where the disease is prevalent, or d) recently returned from a high-pandemic area or country should undergo self-isolation for 14 days. abstract: Endoscopy is widely used as a clinical diagnosis and treatment method for certain hepatobiliary and pancreatic diseases. However, due to the distinctive epidemiological characteristics of SARS‐CoV‐2 (the virus causing COVID‐19), healthcare providers are exposed to the patient’s respiratory and gastrointestinal fluids, rendering endoscopy a high risk for transmitting a nosocomial infection. This article introduces preventive measures for endoscopic treatment enacted in our medical center during COVID‐19, including the adjustment of indications, the application of endoscope protective equipment, the design and application of endoscopic masks and splash‐proof films, and novel recommendations for bedside endoscope pre‐sterilization. url: https://www.ncbi.nlm.nih.gov/pubmed/32702176/ doi: 10.1111/den.13799 id: cord-262784-r9gq2oan author: Tian, Suochen title: Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China date: 2020-05-12 words: 3729.0 sentences: 183.0 pages: flesch: 49.0 cache: ./cache/cord-262784-r9gq2oan.txt txt: ./txt/cord-262784-r9gq2oan.txt summary: title: Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China Methods: We analyzed retrospective data regarding general characteristics, epidemiologic history, underlying chronic diseases, clinical symptoms and complications, chest computed tomography findings, biochemical monitoring, disease severity, treatments, and outcomes among 37 adult patients with COVID-19. Patient diagnosis, release from quarantine, and disease severity among all cases were determined according to the "Protocol for the Diagnosis and Treatment of Novel Coronavirus Pneumonia" issued by the National Health Commission of the People''s Republic of China and the National Administration of Traditional Chinese Medicine (8, 9) . The present study retrospectively analyzed the general characteristics, epidemiological history, chronic underlying diseases, clinical symptoms, complications, chest computed tomography (CT) findings, biochemical features, disease severity, treatment plans, and outcomes of 37 patients. abstract: Objective: This study aimed to identify additional characteristics and features of coronavirus disease (COVID-19) by assessing the clinical courses among COVID-19 patients in a region outside Hubei province. Methods: We analyzed retrospective data regarding general characteristics, epidemiologic history, underlying chronic diseases, clinical symptoms and complications, chest computed tomography findings, biochemical monitoring, disease severity, treatments, and outcomes among 37 adult patients with COVID-19. According to the duration from symptom onset to release from quarantine, the patients were divided into the ≤20 and >20-day groups, and the similarities and differences between them were compared. Results: Among the 37 patients, five had mild disease, 30 had moderate disease, one had severe disease, and one was critically ill. All of the patients were released from quarantine, and no mortality was observed. The average duration from symptom onset to release from quarantine was 20.2 ± 6.6 days. The average duration from symptom onset to hospitalization was 4.1 ± 3.7 days, and the patients were hospitalized for an average of 16.1 ± 6.2 days. The average age was 44.3 ± 1.67 years, and 78.4% of cases were caused by exposure to a patient with confirmed disease or the workplace of a patient with confirmed disease. The main symptoms were cough (67.6%), fever (62.2%), shortness of breath (32.4%), fatigue (24.3%), sore throat (21.6%), vomiting, and diarrhea (21.6%). White blood cell count was decreased in 27.0% of patients, and lymphocyte count was decreased in 62.2% of the patients, among whom 43.5% patients had counts of ≤0.6 × 10(9)/L. On admission, 86.5% of patients showed pneumonia in chest CT scans, including some asymptomatic patients, while 68.8% of patients showed bilateral infiltration. In the >20-day group, the average age was 49.9 ± 1.38 years, and the average duration from symptom onset to hospitalization was 5.5 ± 3.9 days. Compared with the ≤20-day group, patients in the >20-day group were older and the duration was longer (P < 0.05). All of the seven asymptomatic patients belonged to the ≤20-day group. When the 37 patients were released from quarantine, the white blood cell count of 16.2% of the patients was <4.0 × 10(9)/L, the lymphocyte count of 59.5% of the patients was <1.1 × 10(9)/L, and the absolute counts of white blood cells and lymphocytes were 5.02 ± 1.34 × 10(9)/L and 1.03 ± 0.34 × 10(9)/L, respectively, compared with those recorded on admission (P > 0.05). Conclusion: The majority of COVID-19 cases in the study area were mild and moderate, with good clinical outcomes. There were some special characteristics in the clinical course. The reasons for differences in the duration from symptom onset to release from quarantine were complex. There was no significant change in the number of granulocytes at the time of release from quarantine compared to that at the time of admission. url: https://www.ncbi.nlm.nih.gov/pubmed/32574322/ doi: 10.3389/fmed.2020.00210 id: cord-274324-obhrbxu4 author: Tian, Wenjie title: Predictors of mortality in hospitalized COVID‐19 patients: A systematic review and meta‐analysis date: 2020-05-22 words: 3017.0 sentences: 200.0 pages: flesch: 48.0 cache: ./cache/cord-274324-obhrbxu4.txt txt: ./txt/cord-274324-obhrbxu4.txt summary: Our systematic review and meta-analysis of 14 published articles involving 4659 patients is the first to provide a comprehensive analysis of the demographic features, comorbidities, and laboratory abnormalities that are associated with mortality in COVID-19. In this meta-analysis, we found that baseline cardiometabolic disease and evidence of increased acute inflammation and end-organ damage (cardiac, renal, liver and hematologic) on admission were associated with increased risk of mortality due to COVID-19 infection. Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis Arterial hypertension and risk of death in patients with COVID-19 infection: systematic review and meta-analysis Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China abstract: Mortality rates of coronavirus disease 2019 (COVID‐19) continue to rise across the world. Information regarding the predictors of mortality in COVID‐19 patients remains scarce. Herein, we performed a systematic review of published articles, from January 1 to April 24, 2020, to evaluate the risk factors associated with mortality in COVID‐19. Two investigators independently searched the articles and collected the data, in accordance with PRISMA guidelines. We looked for associations between mortality and patient characteristics, comorbidities, and laboratory abnormalities. A total of 14 studies documenting the outcomes of 4659 patients were included. The presence of comorbidities such as hypertension (OR 2.5; 95% CI 2.1‐3.1; P<0.00001), coronary heart disease (OR 3.8; 95% CI 2.1‐6.9; P<0.00001) and diabetes (OR 2.0; 95% CI 1.7‐2.3; P<0.00001) were associated with significantly higher risk of death amongst COVID‐19 patients. Those who died, compared to those who survived, differed on multiple biomarker levels on admission including elevated levels of cardiac troponin (+44.2 ng/L, 95% CI 19.0‐69.4; P=0.0006); C‐reactive protein (+66.3 µg/mL, 95% CI 46.7‐85.9; P<0.00001); interleukin‐6 (+4.6 ng/mL, 95% CI 3.6‐5.6; P<0.00001); D‐dimer (+4.6 µg/mL, 95% CI 2.8‐6.4; P<0.00001); creatinine (+15.3 µmol/L, 95% CI 6.2‐24.3; P=0.001) and alanine transaminase (+5.7 U/L, 95% CI 2.6‐8.8; P=0.0003); as well as decreased levels of albumin (‐3.7 g/L, 95% CI ‐5.3 to ‐2.1; P<0.00001). Individuals with underlying cardiometabolic disease and that present with evidence for acute inflammation and end‐organ damage are at higher risk of mortality due to COVID‐19 infection and should be managed with greater intensity. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32441789/ doi: 10.1002/jmv.26050 id: cord-325201-yoy7kdli author: Timsit, Jean-François title: Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics date: 2015-03-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s00134-015-3755-8 doi: 10.1007/s00134-015-3755-8 id: cord-307660-onz6vfre author: Titanji, Boghuma K title: Use of Baricitinib in Patients with Moderate and Severe COVID-19 date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Cytokine storm and hyperinflammation are associated with increased mortality in COVID-19. In this small uncontrolled cohort of patients with moderate-severe COVID-19, treatment with baricitinib plus hydroxychloroquine was associated with recovery in 11 of 15 patients. Baricitinib for the treatment of COVID-19 should be further investigated in randomized controlled clinical trials. url: https://doi.org/10.1093/cid/ciaa879 doi: 10.1093/cid/ciaa879 id: cord-281561-r10y2sgb author: Tiwari, Nidhi title: Novel β-Coronavirus (SARS-CoV-2): Current and Future Aspects of Pharmacological Treatments date: 2020-08-27 words: 6877.0 sentences: 384.0 pages: flesch: 45.0 cache: ./cache/cord-281561-r10y2sgb.txt txt: ./txt/cord-281561-r10y2sgb.txt summary: Another invitro study reported that Ribavirin, analogue of guanosine nucleotide having wide spectrum of antiviral activity, used along with LPV/RTV to treat SARS-COV-2 viral infection in china (ChiCTR2000029387) . reported remdesivir shows possible efficacy better as compared to placebo group in hospitalized patients for the treatment of SARS-CoV-2 virus. The effectiveness and safety concern of darunavir/cobicistat combination is being evaluated under development of clinical trials phase 3 by enrolling 30 COVID-19 patients and estimated completion of study on December 31, 2020. Recently, retrospective cohort study showed high dose of anakinra (5 mg/kg, BD,iv) produces beneficial and efficacious effects in 72% Covid-19 infected patients associated with ARDS (Cavalli et al., 2020) . Based on case study of patients with SARS-CoV2 infection and also confirmed severe pneumonia and ARDS treated with i.v. infusion of eculizumab along with anticoagulant therapy (Enoxaparin 4000 IU/day s.c), antiviral therapy (LPV 800 mg/day + RTV 200 mg/day), hydroxychloroquine 400 mg/day, ceftriaxone 2 g/day IV, vitamin C 6 g/day for 4 days. abstract: The novel coronavirus outbreak has reported to be rapidly spreading across the countries and becomes a foremost community health alarm. At present, no vaccine or specific drug is on hand for the treatment of this infectious disease. This review investigates the drugs, which are being evaluated and found to be effective against nCOVID-19 infection. A thorough literature search was performedon the recently published research papers in between January 2020 to May 2020, through various databases like “Science Direct”, “Google Scholar”, “PubMed”,“Medline”, “Web of Science”, and “World Health Organization (WHO)”. We reviewed and documented the information related with the current and future aspects for the management and cure of COVID-19. As of 21st July, 2020 a total of 14,562,550 confirmed cases of coronavirus and 607,781 deaths have been reported world-wide. The main clinical feature of COVID-19 ranges from asymptomatic disease to mild lower respiratory tract illness to severe pneumonia, acute lung injury, acute respiratory distress syndrome (ARDS), multiple organ dysfunction, and death. The drugs at present used in COVID-19 patients and ongoing clinical trials focusing on drug repurposing of various therapeutic classes of drug e.g. antiviral, anti-inflammatory and/or immunomodulatory drugs along with adjuvant/supportive care. Many drugs on clinical trials shows effective results on preliminary scale and now used currently in patients. Adjuvant/ supportive care therapy are used in patients to get the best results in order to minimize the short and long-term complications. However, further studies and clinical trials are needed on large scale of population to reach any firm conclusion in terms of its efficacy and safety. url: https://doi.org/10.1016/j.jsps.2020.08.015 doi: 10.1016/j.jsps.2020.08.015 id: cord-254478-scc9wee0 author: To, Kelvin Kai-Wang title: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study date: 2020-03-23 words: 5189.0 sentences: 294.0 pages: flesch: 53.0 cache: ./cache/cord-254478-scc9wee0.txt txt: ./txt/cord-254478-scc9wee0.txt summary: title: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study Comprehensive data for serial respiratory viral load and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not yet available. Nasopharyngeal and throat swabs are usually obtained for serial viral load monitoring of respiratory infections but gathering these specimens can cause discomfort for patients and put health-care workers at risk. We aimed to ascertain the serial respiratory viral load of SARS-CoV-2 in posterior oropharyngeal (deep throat) saliva samples from patients with COVID-19, and serum antibody responses. We present findings of an observational cohort study of the temporal profile of viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from posterior oropharyngeal saliva samples and serum antibody responses, dated by symptom onset and correlated with clinical findings. abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) causes severe community and nosocomial outbreaks. Comprehensive data for serial respiratory viral load and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not yet available. Nasopharyngeal and throat swabs are usually obtained for serial viral load monitoring of respiratory infections but gathering these specimens can cause discomfort for patients and put health-care workers at risk. We aimed to ascertain the serial respiratory viral load of SARS-CoV-2 in posterior oropharyngeal (deep throat) saliva samples from patients with COVID-19, and serum antibody responses. METHODS: We did a cohort study at two hospitals in Hong Kong. We included patients with laboratory-confirmed COVID-19. We obtained samples of blood, urine, posterior oropharyngeal saliva, and rectal swabs. Serial viral load was ascertained by reverse transcriptase quantitative PCR (RT-qPCR). Antibody levels against the SARS-CoV-2 internal nucleoprotein (NP) and surface spike protein receptor binding domain (RBD) were measured using EIA. Whole-genome sequencing was done to identify possible mutations arising during infection. FINDINGS: Between Jan 22, 2020, and Feb 12, 2020, 30 patients were screened for inclusion, of whom 23 were included (median age 62 years [range 37–75]). The median viral load in posterior oropharyngeal saliva or other respiratory specimens at presentation was 5·2 log(10) copies per mL (IQR 4·1–7·0). Salivary viral load was highest during the first week after symptom onset and subsequently declined with time (slope −0·15, 95% CI −0·19 to −0·11; R(2)=0·71). In one patient, viral RNA was detected 25 days after symptom onset. Older age was correlated with higher viral load (Spearman's ρ=0·48, 95% CI 0·074–0·75; p=0·020). For 16 patients with serum samples available 14 days or longer after symptom onset, rates of seropositivity were 94% for anti-NP IgG (n=15), 88% for anti-NP IgM (n=14), 100% for anti-RBD IgG (n=16), and 94% for anti-RBD IgM (n=15). Anti-SARS-CoV-2-NP or anti-SARS-CoV-2-RBD IgG levels correlated with virus neutralisation titre (R(2)>0·9). No genome mutations were detected on serial samples. INTERPRETATION: Posterior oropharyngeal saliva samples are a non-invasive specimen more acceptable to patients and health-care workers. Unlike severe acute respiratory syndrome, patients with COVID-19 had the highest viral load near presentation, which could account for the fast-spreading nature of this epidemic. This finding emphasises the importance of stringent infection control and early use of potent antiviral agents, alone or in combination, for high-risk individuals. Serological assay can complement RT-qPCR for diagnosis. FUNDING: Richard and Carol Yu, May Tam Mak Mei Yin, The Shaw Foundation Hong Kong, Michael Tong, Marina Lee, Government Consultancy Service, and Sanming Project of Medicine. url: https://www.ncbi.nlm.nih.gov/pubmed/32213337/ doi: 10.1016/s1473-3099(20)30196-1 id: cord-310069-ay4af6xr author: Tobin, Martin J. title: Does making a diagnosis of ARDS in COVID-19 patients matter? date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32707184/ doi: 10.1016/j.chest.2020.07.028 id: cord-291873-inzzywps author: Tognetto, Daniele title: Managing ophthalmic practices in a referral emergency COVID‐19 hospital in north‐east Italy date: 2020-06-01 words: 721.0 sentences: 48.0 pages: flesch: 47.0 cache: ./cache/cord-291873-inzzywps.txt txt: ./txt/cord-291873-inzzywps.txt summary: To diminish the risk of contamination, some healthcare facilities, included our hospital, were assigned as referral regional care centre for COVID-19 patients. According to our recent experience, we share a series of measures to prevent the nosocomial transmission of the disease and to reduce the risk of contamination for patients, caregivers and administrative staff. The triaging system screens patients through temperature measurements, and a questionnaire about upper respiratory symptoms, fever, myalgia and anosmia, domicile or travelling in hot areas, and contact history with confirmed or suspected COVID-19 patients within the past 14 days. Patients who meet one of these criteria are addressed to a separate controlled circuit to test for COVID-19 positivity. In our practice, patients with an urgent surgical condition (such as retinal detachment, endophthalmitis, open globe trauma and sight-threatening uncontrolled ocular pressure) are first screened for COVID-19. Precautionary measures needed for ophthalmologists during pandemic of the coronavirus disease 2019 (COVID-19) abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32483923/ doi: 10.1111/aos.14488 id: cord-102199-mc6zruyx author: Toksvang, Linea Natalie title: Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: a systematic review date: 2019-01-30 words: 2340.0 sentences: 144.0 pages: flesch: 40.0 cache: ./cache/cord-102199-mc6zruyx.txt txt: ./txt/cord-102199-mc6zruyx.txt summary: title: Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: a systematic review Hepatotoxicity in the form of sinusoidal obstruction syndrome (SOS) occurred in 9–25% of the ALL patients in two of the four included RCTs using 6TG doses of 40–60 mg/m2/day, and long-term hepatotoxicity in the form of nodular regenerative hyperplasia (NRH) was reported in 2.5%. Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children''s Oncology Group CCG-1952 clinical trial 6-Thioguanine associated nodular regenerative hyperplasia in patients with inflammatory bowel disease may induce portal hypertension Splitting a therapeutic dose of thioguanine may avoid liver toxicity and be an efficacious treatment for severe inflammatory bowel disease: a 2-center observational cohort study Early nodular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapy abstract: Background The recently established association between higher levels of DNA-incorporated thioguanine nucleotides and lower relapse risk in childhood acute lymphoblastic leukaemia (ALL) calls for reassessment of prolonged 6-thioguanine (6TG) treatment, while avoiding the risk of hepatotoxicity. Objectives To assess the incidence of hepatotoxicity in patients treated with 6TG, and to explore if a safe dose of continuous 6TG can be established. Data sources Databases, conference proceedings, and reference lists of included studies were systematically searched for 6TG and synonyms from 1998–2018. Methods We included studies of patients with ALL or inflammatory bowel disorder (IBD) treated with 6TG, excluding studies with 6TG as part of an intensive chemotherapy regimen. We uploaded a protocol to PROSPERO (registration number CRD42018089424). Database and manual searches yielded 1823 unique records. Of these, 395 full-texts were screened for eligibility. Finally, 134 reports representing 42 studies were included. Results and conclusions We included data from 42 studies of ALL and IBD patients; four randomised controlled trials (RCTs) including 3,993 patients, 20 observational studies including 796 patients, and 18 case reports including 60 patients. Hepatotoxicity in the form of sinusoidal obstruction syndrome (SOS) occurred in 9–25% of the ALL patients in two of the four included RCTs using 6TG doses of 40–60 mg/m2/day, and long-term hepatotoxicity in the form of nodular regenerative hyperplasia (NRH) was reported in 2.5%. In IBD patients treated with 6TG doses of approximately 23 mg/m2/day, NRH occurred in 14% of patients; SOS has not been reported. At a 6TG dose of approximately 12 mg/m2/day, NRH was reported in 6% of IBD patients, which is similar to the background incidence. According to this review, doses at or below 12 mg/m2/day are rarely associated with notable hepatotoxicity and can probably be considered safe. url: https://doi.org/10.1101/535518 doi: 10.1101/535518 id: cord-017016-twwa9djm author: Tomashefski, Joseph F. title: Aspiration, Bronchial Obstruction, Bronchiectasis, and Related Disorders date: 2008 words: 20053.0 sentences: 1313.0 pages: flesch: 40.0 cache: ./cache/cord-017016-twwa9djm.txt txt: ./txt/cord-017016-twwa9djm.txt summary: These occult aspirations may lead to interstitial fibrosis, and perhaps account for the 20% to 54 % incidence of associated and unexplained pulmonary fibrosis in patients with esophageal abnormalities, most commonly hiatal hernia or simple reflux,39,40 The role of reflux in asthma, chronic bronchitis, chronic cough, recurrent pneumonia, cystic fibrosis, and sudden infant death syndrome has been reviewed by Allen et al. 130 In their reviews, Phillips and Rao l3l and Penner and colleagues130 note that similar predisposing factors as those with community-acquired pneumonia, such as aspiration and abscess formation, pertain to this entity, but the location helps distinguish it from the other typical sites of aspiration, When in the upper lobes, it appears to progress through necrotizing pneumonia with thrombosis of arteries (pulmonary and bronchial) and veins, [129] [130] [131] Although not strictly abiding by the foregoing definition (of localization in upper lobe), in one case total unilateral lung gangrene was attributed to hilar vessel involvement following treatment of a massive hilar recurrence of Hodgkin''s disease. abstract: The conducting airways play a pivotal role in the spectrum of pulmonary pathology, not only as conduits for injurious agents to enter the lung, but also as an anatomic compartment that is affected by a diverse array of primary or secondary bronchocentric diseases. This chapter discusses aspiration and bronchial obstruction in detail, with emphasis on the aspiration of toxic, infective, or particulate matter. Lung abscess, a frequent complication of obstruction or aspiration, is also reviewed. Both aspiration and lung abscess are reconsidered within the context of pulmonary infectious disease mainly in Chapter 8 on bacterial infections, and to some extent in the chapters on mycobacterial (Chapter 9), fungal (Chapter 10), and parasitic diseases (Chapter 14). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121473/ doi: 10.1007/978-0-387-68792-6_5 id: cord-337010-dgy7qbl5 author: Tomazini, B. M. title: COVID-19-associated ARDS treated with DEXamethasone (CoDEX): Study design and rationale for a randomized trial. date: 2020-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) spreads worldwide and is considered a pandemic. The most common manifestation of SARS-CoV2 infection (Coronavirus disease 2019 - COVID-19) is viral pneumonia with varying degrees of respiratory compromise and up to 40% of hospitalized patients might develop Acute Respiratory Distress Syndrome (ARDS). Several clinical trials evaluated the role of corticosteroids in non-COVID-19 ARDS with conflicting results. We designed a trial to evaluate the effectiveness of early intravenous dexamethasone administration on the number of days alive and free of mechanical ventilation within 28 days after randomization in adult patients with moderate or severe ARDS due to confirmed or probable COVID-19. METHODS: This is a pragmatic, prospective, randomized, stratified, multicenter, open-label, controlled trial including 350 patients with early-onset (less than 48h before randomization) moderate or severe ARDS, defined by the Berlin criteria, due to COVID-19. Eligible patients will be randomly allocated to either standard treatment plus dexamethasone (intervention group) or standard treatment without dexamethasone (control group). Patients in the intervention group will receive dexamethasone 20mg IV once daily for 5 days, followed by dexamethasone 10mg IV once daily for additional 5 days or until Intensive Care Unit (ICU) discharge, whichever occurs first. The primary outcome is ventilator-free days within 28 days after randomization, defined as days alive and free from invasive mechanical ventilation. Secondary outcomes are all-cause mortality rates at day 28, evaluation of the clinical status at day 15 assessed with a 6-level ordinal scale, mechanical ventilation duration from randomization to day 28, Sequential Organ Failure Assessment (SOFA) Score evaluation at 48h, 72h and 7 days and ICU-free days within 28. ETHICS AND DISSEMINATION: This trial was approved by the Brazilian National Committee of Ethics in Research (Comissao Nacional de Etica em Pesquisa - CONEP) and National Health Surveillance Agency (ANVISA). An independent data monitoring committee will perform interim analyses and evaluate adverse events throughout the trial. Results will be submitted for publication after enrolment and follow-up are complete. url: http://medrxiv.org/cgi/content/short/2020.06.24.20139303v1?rss=1 doi: 10.1101/2020.06.24.20139303 id: cord-329741-604gtqx9 author: Tombetti, Enrico title: Novel Pharmacotherapies for Recurrent Pericarditis: Current Options in 2020 date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: ABSTRACT: Recent advances have shown impressive results by anti-interleukin 1 (IL-1) agents in refractory idiopathic recurrent pericarditis. PURPOSE OF REVIEW: We critically discuss the current state of the art of therapy of relapsing pericarditis, with a focus on new pharmacological approaches and on specific clinical settings such as pregnancy, pediatric patients, and secondary forms of relapsing pericarditis. RECENT FINDINGS: Antagonism of the IL-1 is highly effective in idiopathic recurrent pericarditis with autoinflammatory features. Currently, available anti-IL-1 agents are anakinra and canakinumab. Rilonacept is another IL-1 antagonist, currently studied in the phase-3 clinical trial RHAPSODY. Available data suggest similar efficacy and safety profiles of these three agents, although only anakinra has been tested in randomized clinical trials. These agents have slightly different pharmacological properties, being canakinumab a specific IL-1ß antagonist while anakinra and rilonacept are unselective IL-1α and IL-1ß blockers. To date, there is no evidence that specificity against IL-1ß affects safety and efficacy in patients with relapsing pericarditis, although it has been proposed that unspecific blockage might be useful in severe disease. SUMMARY: Anakinra is the first anti-IL-1 agent with well-documented efficacy and safety in adult and pediatric patients with idiopathic relapsing pericarditis. Other anti-IL-1 agents are currently under study. Future research should clarify the optimal duration of therapy and tapering schedule of treatment with these agents. Moreover, biomarkers would be required to understand which patients will benefit from early administration of IL-1 blockers due to refractoriness to conventional therapy and which others will suffer from recurrences during the tapering of these agents. Lastly, future studies should focus on the subjects with the autoimmune or the pauci-inflammatory phenotype of idiopathic refractory pericarditis. url: https://www.ncbi.nlm.nih.gov/pubmed/32562029/ doi: 10.1007/s11886-020-01308-y id: cord-310001-qng7h5cj author: Tomlins, Jennifer title: Clinical features of 95 sequential hospitalised patients with novel coronavirus 2019 disease (COVID-19), the first UK cohort date: 2020-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S0163445320302322 doi: 10.1016/j.jinf.2020.04.020 id: cord-001313-f72hl6du author: Toncheva, D. title: NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy date: 2014-05-15 words: 3648.0 sentences: 217.0 pages: flesch: 40.0 cache: ./cache/cord-001313-f72hl6du.txt txt: ./txt/cord-001313-f72hl6du.txt summary: Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression leading to terminal renal failure. Mutant genes (CELA1, HSPG2, and KCNK5) in BEN patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis. Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression to terminal renal failure. In the present study we aimed to perform exome sequencing of 22 000 genes with the Illumina Nextera Exome Enrichment Kit using NGS technology in order to find specific mutations for BEN. have intensively studied the pathological changes in the kidneys of BEN patients and presented evidence that renal vascular changes occur early in Balkan nephropathy [30] . MDR1 haplotypes modify BEN disease risk: a study in Bulgarian patients with Balkan endemic nephropathy compared to healthy controls abstract: Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression leading to terminal renal failure. The results of molecular biological investigations propose that BEN is a multifactorial disease with genetic predisposition to environmental risk agents. Exome sequencing of 22 000 genes with Illumina Nextera Exome Enrichment Kit was performed on 22 DNA samples (11 Bulgarian patients and 11 Serbian patients). Software analysis was performed via NextGene, Provean, and PolyPhen. The frequency of all annotated genetic variants with deleterious/damaging effect was compared with those of European populations. Then we focused on nonannotated variants (with no data available about them and not found in healthy Bulgarian controls). There is no statistically significant difference between annotated variants in BEN patients and European populations. From nonannotated variants with more than 40% frequency in both patients' groups, we nominated 3 genes with possible deleterious/damaging variants—CELA1, HSPG2, and KCNK5. Mutant genes (CELA1, HSPG2, and KCNK5) in BEN patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis. We suggest that an abnormal process of angiogenesis plays a key role in the molecular pathogenesis of BEN. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052113/ doi: 10.1155/2014/920723 id: cord-278993-w5aa0elj author: Tonetti, Tommaso title: Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy date: 2020-10-12 words: 3922.0 sentences: 171.0 pages: flesch: 44.0 cache: ./cache/cord-278993-w5aa0elj.txt txt: ./txt/cord-278993-w5aa0elj.txt summary: We retrospectively studied consecutive critically ill patients with confirmed Covid-19 who were referred to the hospitals of the Lombardy, Veneto and Emilia-Romagna regions during the first 2 weeks of the Italian outbreak (February 24March 8, 2020) . The present study describes how the Italian health-care system of three northern Italian regions responded to the increasing need for clinical resources for critically ill patients during the first 14 days of the Covid-19 outbreak through the 28.7% increase in ICU beds and the increasing use of non-invasive respiratory support outside the ICU. Our data show that, compared to patients admitted to the ICU, patients receiving respiratory support outside the ICU were significantly older, had more comorbidities and had a higher PaO 2 /FiO 2 ratio and a lower PaCO 2 . abstract: BACKGROUND: A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear of an imminent saturation of available ICU beds generated the notion that rationing of intensive care resources could have been necessary. RESULTS: In order to evaluate the impact of Covid-19 on the ICU capacity to manage critically ill patients, we performed a retrospective analysis of the first 2 weeks of the outbreak (February 24–March 8). Data were collected from regional registries and from a case report form sent to participating sites. ICU beds increased from 1545 to 1989 (28.7%), and patients receiving respiratory support outside the ICU increased from 4 (0.6%) to 260 (37.0%). Patients receiving respiratory support outside the ICU were significantly older [65 vs. 77 years], had more cerebrovascular (5.8 vs. 13.1%) and renal (5.3 vs. 10.0%) comorbidities and less obesity (31.4 vs. 15.5%) than patients admitted to the ICU. PaO(2)/FiO(2) ratio, respiratory rate and arterial pH were higher [165 vs. 244; 20 vs. 24 breath/min; 7.40 vs. 7.46] and PaCO(2) and base excess were lower [34 vs. 42 mmHg; 0.60 vs. 1.30] in patients receiving respiratory support outside the ICU than in patients admitted to the ICU, respectively. CONCLUSIONS: Increase in ICU beds and use of out-of-ICU respiratory support allowed effective management of the first 14 days of the Covid-19 outbreak, avoiding resource rationing. url: https://www.ncbi.nlm.nih.gov/pubmed/33044646/ doi: 10.1186/s13613-020-00750-z id: cord-015640-zdwmxaz3 author: Tong, C. Y. W. title: Clinical Virology in NICU, PICU and AICU date: 2011-08-10 words: 6051.0 sentences: 356.0 pages: flesch: 44.0 cache: ./cache/cord-015640-zdwmxaz3.txt txt: ./txt/cord-015640-zdwmxaz3.txt summary: Viruses are significant causes of nosocomial infections, particularly in intensive care unit (ICU) where seriously ill and vulnerable patients are being cared for. Adherence to effective infection control measures (hand hygiene, enteric precautions; Table 20 .3), as well as adequate staffing and patient cohorting/ isolation can therefore help prevent or manage an outbreak [41] . Neonates and immunocompromised patients can shed the virus for a prolonged time over months, which emphasises the need for rigorous adherence to effective infection control measures (Table 20. Postexposure prophylaxis (PEP) should therefore be offered to all health care workers who have significant exposure to blood or body fluid from a patient known to be at high risk of or to have HIV infection. Preliminary estimation of risk factors for admission to intensive care units and for death in patients infected with A(H1N1)2009 influenza virus abstract: Viruses are significant causes of nosocomial infections, particularly in intensive care unit (ICU) where seriously ill and vulnerable patients are being cared for. Four major routes of nosocomial virus transmission in the ICU are identified, viz. respiratory, faecal–oral, exposure to blood and body fluid and direct contact with infected patients or through fomites. Different infection control measures are available according to the natural history, biology, pathogenesis, epidemiology and mode of transmission of each virus. In this chapter, we discuss some of the important viruses that could be associated with nosocomial infections in the ICU. Intensivists should work closely with microbiologists, virologists and the laboratory to diagnose such infection early, work proactively to prevent outbreaks and manage viral infections using appropriate strategies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114968/ doi: 10.1007/978-88-470-1601-9_20 id: cord-329351-g9qlo3xh author: Toraih, Eman A. title: Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID‐19 patients: A meta‐regression and Decision tree analysis date: 2020-06-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease‐2019 (COVID‐19) has a deleterious effect on several systems, including the cardiovascular system. We aim to systematically explore the association of COVID‐19 severity and mortality rate with the history of cardiovascular diseases and/or other comorbidities and cardiac injury laboratory markers. METHODS: The standardized mean difference (SMD) or odds ratio (OR) and 95% confidence intervals (CI) were applied to estimate pooled results from the 56 studies. The prognostic performance of cardiac markers for predicting adverse outcomes and to select the best cutoff threshold was estimated by ROC curve analysis. Decision tree analysis by combining cardiac markers with demographic and clinical features was applied to predict mortality and severity in COVID‐19 patients. RESULTS: A meta‐analysis of 17,794 patients showed patients with high cardiac troponin I (OR=5.22, 95%CI=3.73‐7.31, p<0.001) and AST levels (OR=3.64, 95%CI=2.84‐4.66, p<0.001) were more likely to develop adverse outcomes. High troponin I >13.75 ng/L combined with either advanced age >60 years or elevated AST level >27.72 U/L was the best model to predict poor outcomes. CONCLUSIONS: COVID‐19 severity and mortality are complicated by myocardial injury. Assessment of cardiac injury biomarkers may improve the identification of those patients at the highest risk and potentially lead to improved therapeutic approaches. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32530509/ doi: 10.1002/jmv.26166 id: cord-356371-w9ejgzvu author: Torres-González, JI title: What has happened to care during the COVID-19 pandemic? date: 2020-07-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2529984020300409?v=s5 doi: 10.1016/j.enfie.2020.07.001 id: cord-341118-h5t87vf8 author: Torres‐Navarro, Ignacio title: A case of cefditoren‐induced Acute Generalized Exanthematous Pustulosis during COVID‐19 pandemics. Severe Cutaneous Adverse Reactions (SCARs) are an issue date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We read with interest the article by Recalcati et al. about the report of cutaneous manifestations in COVID‐19 patients. We would like to highlight that some potentially severe manifestations in these patients are not directly related to the coronavirus but to the medications administered. url: https://www.ncbi.nlm.nih.gov/pubmed/32455478/ doi: 10.1111/jdv.16664 id: cord-260981-647wfa8z author: Torti, Lorenza title: Impact of SARS CoV-2 in Hemoglobinopathies with Immune Disfunction and Epidemiology. A Protective Mechanism from Beta Chain Hemoglobin Defects? date: 2020-07-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.4084/mjhid.2020.052 doi: 10.4084/mjhid.2020.052 id: cord-293522-gg706q8s author: Toumi, Mondher title: Commentary on “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial” by Gautret et al date: 2020-05-13 words: 5234.0 sentences: 277.0 pages: flesch: 51.0 cache: ./cache/cord-293522-gg706q8s.txt txt: ./txt/cord-293522-gg706q8s.txt summary: title: Commentary on "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial" by Gautret et al The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were recently published by Philippe Gautret et al. This study provides outstanding results for the combination of hydroxychloroquine and azithromycin over the standard of care, but the evidence was deemed insufficiently robust to warrant a public health decision to widen the use of hydroxychloroquine for the treatment of COVID-19. The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were published in the International Journal of Antimicrobial Agents by Philippe Gautret et al. The US Centers for Disease Control and Prevention provides information on the use of hydroxychloroquine and chloroquine in the USA to treat coronavirus 2infected patients. abstract: The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were recently published by Philippe Gautret et al. This study provides outstanding results for the combination of hydroxychloroquine and azithromycin over the standard of care, but the evidence was deemed insufficiently robust to warrant a public health decision to widen the use of hydroxychloroquine for the treatment of COVID-19. We provide a scientific critical review of the Gautret et al. publication, put the results in the context of the current knowledge, provide an evaluation of the validity of the results (from a methodologic perspective), and discuss public health implications. The study has a number of limitations, including small sample size, lack of comparability between patients in active treatment and control arms, lack of blinding, use of interim analyses without controlling for the risk of type 1 error, use of analysis in the per-protocol population instead of the intention-to-treat population, and inconsistencies between the study protocol and article. However, none of these observations is of a nature to reverse the conclusions. The study brings useful knowledge consistent with available evidence and clinical practice from China and South Korea, which could have prompted quicker policy decision-making. url: https://www.ncbi.nlm.nih.gov/pubmed/32537099/ doi: 10.1080/20016689.2020.1758390 id: cord-316572-7ei96rrn author: Touska, P title: The role of transoral fine needle aspiration in expediting diagnosis and reducing risk in head and neck cancer patients in the coronavirus disease 2019 (COVID-19) era: a single-institution experience date: 2020-09-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: The global coronavirus disease 2019 (COVID-19) pandemic has necessitated rapid alterations to diagnostic pathways for head and neck cancer patients that aim to reduce risk to patients (exposure to the hospital environment) and staff (aerosol-generating procedures). Transoral fine needle aspiration cytology offers a low-risk means of rapidly diagnosing patients with oral cavity or oropharyngeal lesions. The technique was utilised in selected patients at our institution during the pandemic. The outcomes are considered in this study. METHOD: Diagnostic outcomes were retrospectively evaluated for a series of patients undergoing transoral fine needle aspiration cytology of oral cavity and oropharyngeal lesions during the COVID-19 pandemic. RESULTS: Five patients underwent transoral fine needle aspiration cytology, yielding lesional material in 100 per cent, with cell blocks providing additional information. In one case, excision biopsy of a lymphoproliferative lesion was required for final diagnosis. CONCLUSION: Transoral fine needle aspiration cytology can provide rapid diagnosis in patients with oral cavity and oropharyngeal lesions. Whilst limitations exist (including tolerability and lesion location), the technique offers significant advantages pertinent to the COVID-19 era, and could be employed in the future to obviate diagnostic surgery in selected patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32873344/ doi: 10.1017/s0022215120001929 id: cord-266450-g9vihgbk author: Tran, Michael title: SARS-CoV-2 and pulmonary embolism: who stole the platelets? date: 2020-09-03 words: 1498.0 sentences: 93.0 pages: flesch: 38.0 cache: ./cache/cord-266450-g9vihgbk.txt txt: ./txt/cord-266450-g9vihgbk.txt summary: Careful attention to his daily platelet count suggested the possibility of immune mediated heparin-induced thrombocytopenia (HIT) which was confirmed by laboratory testing and resolved when anticoagulation was switched to a direct thrombin inhibitor. CONCLUSIONS: Since excessive platelet activation and in situ thrombosis occur in HIT, this case underscores the need to consider that thrombocytopenia in patients with SARS-CoV-2—most of whom receive heparinoids—may be unrecognized HIT. Emerging reports suggest the possibility of HIT developing in SARS-CoV-2 patients receiving heparin anticoagulation [4, 5] . The patient''s platelet count decreased from 487 k/uL to a nadir of 91 k/uL over the following 4 days, raising the concern for heparin induced thrombocytopenia (HIT) with an intermediate pretest probability by the 4Ts score of 4 ( Table 1 ). Platelet count and time points for anticoagulation administration and laboratory testing COVID-19 patients receiving heparin-involved treatment. abstract: BACKGROUND: Patients infected with SARS-CoV-2 often develop venous and arterial thrombosis. The high patient mortality is partly attributed to thrombotic events. An emerging trend is the presence of immunological phenomena including antiphospholipid antibodies which may promote thrombosis. The mechanism for these observations is not clear though many patients with SARS-CoV-2 develop thrombocytopenia. CASE PRESENTATION: We describe a patient with SARS-CoV-2 pneumonitis who presented with intermediate risk pulmonary embolism (PE). Careful attention to his daily platelet count suggested the possibility of immune mediated heparin-induced thrombocytopenia (HIT) which was confirmed by laboratory testing and resolved when anticoagulation was switched to a direct thrombin inhibitor. CONCLUSIONS: Since excessive platelet activation and in situ thrombosis occur in HIT, this case underscores the need to consider that thrombocytopenia in patients with SARS-CoV-2—most of whom receive heparinoids—may be unrecognized HIT. A central role for the platelet in the etiology of thrombosis during the COVID-19 pandemic should be explored. url: https://www.ncbi.nlm.nih.gov/pubmed/32905282/ doi: 10.1186/s12959-020-00229-8 id: cord-333113-0k6xlmem author: Tran, V.-T. title: Association between corticosteroids and intubation or death among patients with COVID-19 pneumonia in non-ICU settings: an observational study using of real-world data from 51 hospitals in France and Luxembourg date: 2020-09-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective To assess the effectiveness of corticosteroids on outcomes of patients with mild COVID-19 pneumonia. Methods We used routine care data from 51 hospitals in France and Luxembourg to assess the effectiveness of corticosteroids at 0.8 mg/kg/day eq. prednisone (CTC group) vs standard of care (no-CTC group) among patients [≤] 80 years old with COVID-19 pneumonia requiring oxygen without mechanical ventilation. The primary outcome was intubation or death at Day 28. Baseline characteristics of patients were balanced using propensity score inverse probability of treatment weighting. Results Among the 891 patients included in the analysis, 203 were assigned to the CTC group. At day 28, corticosteroids did not reduce the rate of the primary outcome (wHR 0.92, 95% CI 0.61 to 1.39) nor the cumulative death rate (wHR 1.03, 95% CI 0.54 to 1.98). Corticosteroids significantly reduced the rate of the primary outcome for patients requiring oxygen [≥] at 3L/min (wHR 0.50, 95% CI 0.30 to 0.85) or C-Reactive Protein (CRP) [≥] 100mg/L (wHR 0.44, 95%CI 0.23 to 0.85). We found a higher number of hyperglycaemia events among patients who received corticosteroids, but number of infections were similar across the two groups. Conclusions We found no association between the use of corticosteroids and intubation or death in the broad population of patients [≤]80 years old with COVID-19 hospitalized in non-ICU settings. However, the treatment was beneficial for patients with [≥] 3L/min oxygen or CRP [≥] 100mg/L at baseline. These data support the need to confirm the right timing of corticosteroids for patients with mild COVID. url: https://doi.org/10.1101/2020.09.16.20195750 doi: 10.1101/2020.09.16.20195750 id: cord-273175-bao8xxe2 author: Tran, Viet-Thi title: COVID-19–related perceptions, context and attitudes of adults with chronic conditions: Results from a cross-sectional survey nested in the ComPaRe e-cohort date: 2020-08-06 words: 3858.0 sentences: 205.0 pages: flesch: 49.0 cache: ./cache/cord-273175-bao8xxe2.txt txt: ./txt/cord-273175-bao8xxe2.txt summary: It assessed participants'' perception of their risk of severe illness with COVID-19; their context (i.e., work, household, contacts with external people); and their attitudes in situations involving frequent or occasional contacts with symptomatic or asymptomatic people. Results of the survey were described globally and for the subgroup of patients considered at high risk of a severe illness according to the French High Council for Public Health (Box 1). Among patients at high risk of a severe illness according to the French High Council for Public Health, 5% continued working, 15% had a household member working outside of the home and 7% reported regular contacts with people outside of their home. The only variable found associated with use of face masks with asymptomatic people (or refusal to see these people) was patients'' perception of high risk of severe infection by COVID-19 (odds ratio 1.93, 95% confidence interval 1.53-2.43). abstract: BACKGROUND: To avoid a surge of demand on the healthcare system due to the COVID-19 pandemic, we must reduce transmission to individuals with chronic conditions who are at risk of severe illness with COVID-19. We aimed at understanding the perceptions, context and attitudes of individuals with chronic conditions during the COVID-19 pandemic to clarify their potential risk of infection. METHODS: A cross-sectional survey was nested in ComPaRe, an e-cohort of adults with chronic conditions, in France. It assessed participants’ perception of their risk of severe illness with COVID-19; their context (i.e., work, household, contacts with external people); and their attitudes in situations involving frequent or occasional contacts with symptomatic or asymptomatic people. Data were collected from March 23 to April 2, 2020, during the lockdown in France. Analyses were weighted to represent the demographic characteristics of French patients with chronic conditions. The subgroup of participants at high risk according to the recommendations of the French High Council for Public Health was examined. RESULTS: Among the 7169 recruited participants, 63% patients felt at risk because of severe illness. About one quarter (23.7%) were at risk of infection because they worked outside home, had a household member working outside home or had regular visits from external contacts. Less than 20% participants refused contact with symptomatic people and <20% used masks when in contact with asymptomatic people. Among patients considered at high risk according to the recommendations of the French High Council for Public Health, 20% did not feel at risk, which led to incautious attitudes. CONCLUSION: Individuals with chronic conditions have distorted perceptions of their risk of severe illness with COVID-19. In addition, they are exposed to COVID-19 due to their context or attitudes. url: https://doi.org/10.1371/journal.pone.0237296 doi: 10.1371/journal.pone.0237296 id: cord-297759-arg71du6 author: Triantafyllou, Tania title: Esophageal cancer: challenges, concerns, and recommendations for management amidst the COVID-19 pandemic date: 2020-06-22 words: 3740.0 sentences: 157.0 pages: flesch: 30.0 cache: ./cache/cord-297759-arg71du6.txt txt: ./txt/cord-297759-arg71du6.txt summary: The primary aim of this review is to summarize the salient evidence for recommendations and optimal treatment strategies for patients with esophageal cancer amidst the COVID-19 pandemic. In a viral pandemic, clinicians should balance the need to perform life-prolonging surgery and offer perioperative therapies with a patient''s risk of contracting severe pneumonia if infected with SARS-CoV-2. The active surveillance strategy could be an alternative approach for clinically complete responders after neoadjuvant therapy in an effort to avoid possible exposure to COVID-19, which may be particularly beneficial considering the patients'' immunosuppressed status [23] . Similarly to the organ-preserving approach in rectal cancer patients who present a complete response after neoadjuvant or definite therapies, the "active surveillance" pathways have been designed as a rationale for clinical complete responders after neoadjuvant chemoradiotherapy in the treatment of EC. Active surveillance versus immediate surgery in clinically complete responders after neoadjuvant chemoradiotherapy for esophageal cancer: a multicenter propensity matched study abstract: Since December 2019, the outbreak of coronavirus disease 2019 (COVID-19) has rapidly spread worldwide, raising great concern, particularly in immunosuppressed cancer patients. The pandemic situation remains extremely dynamic, which necessitates proactive management decisions from oncologists and oncologic surgeons in effort to mitigate the risk of both SARS-CoV-2 infection and cancer metastasis. Esophageal cancer, in particular, is one of the deadliest types of malignancy worldwide, reflecting both aggressive biology and a lack of adequate treatment. Several challenges and concerns regarding the management of esophageal cancer have been raised in light of the ongoing viral pandemic. The primary aim of this review is to summarize the salient evidence for recommendations and optimal treatment strategies for patients with esophageal cancer amidst the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32879590/ doi: 10.20524/aog.2020.0519 id: cord-275477-blu6wjhu author: Trimaille, Antonin title: COVID-19 et pathologie thromboembolique veineuse date: 2020-09-29 words: 2413.0 sentences: 227.0 pages: flesch: 50.0 cache: ./cache/cord-275477-blu6wjhu.txt txt: ./txt/cord-275477-blu6wjhu.txt summary: Fréquence de la pathologie thrombo-embolique veineuse au cours des formes modérées de J o u r n a l P r e -p r o o f Dans une étude analyse une cohorte de 1240 patients consécutifs hospitalisés en dehors des services de Réanimation pour des formes modérées de COVID-19, les auteurs ont observé une incidence d''embolie pulmonaire confirmée à l''angioscanner de 8.3% (17) . En outre, il semble que les ETEV pourraient en partie survenir de manière asymptomatique au cours de la COVID-19 dans la mesure où les études utilisant un screening systématique ont retrouvé des incidences d''ETEV allant jusqu''à près de 50% des patients hospitalisés avec formes modérées (22, 23) . Helms et al ont observé une incidence de complications thrombo-emboliques de 18 Ainsi, les patients hospitalisés pour une forme sévère de COVID-19, en service de réanimation, présentent des ETEV très fréquemment, potentialisant la sévérité de l''atteinte respiratoire. abstract: La coronavirus disease 2019 (COVID-19) s’accompagne d’une incidence élevée d’événements thromboemboliques veineux (ETEV). Souvent asymptomatiques, ils ont un impact défavorable sur le pronostic des patients. En plus des facteurs de risque de thrombose veineuse auxquels les formes de COVID-19 nécessitant une hospitalisation exposent (alitement prolongée, hypoxémie, présence de matériel intraveineux), les caractéristiques des patients atteints des formes les plus sévères (âge élevé, obésité) expliquent en partie la fréquence des ETEV. De plus, la COVID-19 entraine une maladie de l’endothélium vasculaire par une invasion directe des cellules endothéliales, à l’origine d’une endothéliite, et un état prothrombotique secondaire à l’intense réaction inflammatoire. L’ensemble de ces manifestations entrainent une immuno-thrombose localisée principalement au niveau du lit vasculaire pulmonaire. La stratification du risque thrombo-embolique veineux pour proposer aux patients un niveau d’anticoagulation adapté apparait ainsi comme un des piliers du traitement de la COVID-19. Les recommandations émises jusqu’ici se basent sur des avis d’experts dans la mesure où les données sur l’anticoagulation au cours de la COVID-19 proviennent essentiellement d’études observationnelles. Des essais cliniques contrôlés et randomisés sont en cours et permettront d’améliorer la gestion de la maladie thrombo-embolique veineuse au cours de la COVID-19. Coronavirus disease 2019 (COVID-19) is associated with an increased incidence of venous thromboembolism (VTE). Frequently asymptomatic, VTE has a negative impact on patients clinical course. On top of traditional VTE risk factors encountered during COVID-19 such as prolonged bed rest, hypoxemia and intravascular material, main features of patients with severe forms (old age, obesity) explain in part the VTE frequency. In addition, COVID-19 causes an endothelial disease following endotheliitis after the direct invasion of endothelial cells and a prothrombotic state secondary to the strong inflammatory response to infection. Altogether, these mechanisms lead to an extensive immunothrombosis within the pulmonary vasculature. VTE risk stratification to prescribe adequate anticoagulation is an imperious requirement in the COVID-19 treatment. So far, guidelines are mainly based on observational data. Randomized controlled clinical trials are ongoing and will allow to precise the anticoagulant regiment of patients hospitalized for COVID-19. url: https://www.sciencedirect.com/science/article/pii/S0003392820301360?v=s5 doi: 10.1016/j.ancard.2020.09.027 id: cord-296013-6ej3pd0u author: Trinidad, John title: Telemedicine for Inpatient Dermatology Consultations in Response to the COVID-19 Pandemic date: 2020-04-24 words: 328.0 sentences: 25.0 pages: flesch: 40.0 cache: ./cache/cord-296013-6ej3pd0u.txt txt: ./txt/cord-296013-6ej3pd0u.txt summary: key: cord-296013-6ej3pd0u title: Telemedicine for Inpatient Dermatology Consultations in Response to the COVID-19 Pandemic cord_uid: 6ej3pd0u 3 Inpatient 46 dermatology services will continue to provide impactful care throughout the COVID-19 crisis 47 with a particular need to help allocate scarce resources. Outpatient 55 teledermatology services have the potential to increase access to dermatology care, and to 56 address health care disparities for urban-underserved and rural populations. 5 Dermatologists are poised to 58 utilize teledermatology to increase access to dermatologic care for hospitalized patients, reduce 59 the risk of infection of patients, trainees and staff, and reduce the use of precious resources such 60 as personal protective equipment (PPE) and medical supplies. Characterisation and diagnosis of ulcers in 108 inpatient dermatology consultation services: A multi-centre study Improved patient access and outcomes with the 111 integration of an eConsult program (teledermatology) within a large academic medical 112 center abstract: nan url: https://api.elsevier.com/content/article/pii/S019096222030712X doi: 10.1016/j.jaad.2020.04.096 id: cord-336462-7dltsav4 author: Trovik, Linn Hereide title: Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report date: 2020-11-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare heterogenous genetic or acquired hyperinflammatory syndrome associated with a high degree of morbidity and mortality. HLH has clinical manifestations related to abnormal prolonged activation of T lymphocytes and macrophages with an excess of proinflammatory cytokines. The main causes of secondary HLH are malignancies and infectious diseases. CASE PRESENTATION: The patient was a 54-year-old man, originally from Eastern Africa, who had lived in Northern Europe for 30 years. Here we describe the clinical features, laboratory parameters, diagnostic workup, management and outcome data of a previously healthy 54-year-old man diagnosed with HLH secondary to tuberculosis. The patient was initially treated for a community-acquired pneumonia. He developed multiorgan failure with acute respiratory distress syndrome, hypertransaminasemia, and kidney and bone marrow dysfunction. The clinical course together with a simultaneous increase in serum ferritin raised the suspicion of HLH. The patient fulfilled seven out of eight diagnostic criteria for HLH. A thorough diagnostic workup with respect to HLH and a potential underlying disease was initiated. Cultivation of bronchoalveolar lavage fluid, stool and urine, and polymerase chain reaction of epithelioid cell granulomas in the bone marrow were all positive for Mycobacterium tuberculosis. He was treated for both HLH and tuberculosis, and he survived without any sequelae. CONCLUSIONS: We present one of few published cases of a patient who survived HLH triggered by miliary tuberculosis. The current case illustrates the need for awareness of these two diagnoses, and the timely initiation of specific and supportive treatment to reduce mortality. url: https://www.ncbi.nlm.nih.gov/pubmed/33172493/ doi: 10.1186/s13256-020-02555-x id: cord-335576-b34nc3ay author: Tsai, Andrew title: Impact of tocilizumab administration on mortality in severe COVID-19 date: 2020-11-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus disease 2019 (COVID-19) worldwide pandemic has placed a significant burden on hospitals and healthcare providers. The immune response to this disease is thought to lead to an aberrant inflammatory response or cytokine storm, which contributes to the severity of illness. There is an urgent need to confirm whether the use of tocilizumab provides a benefit in individuals with COVID-19. A single-center propensity-score matched cohort study, including all consecutive COVID-19 patients, admitted to the medical center who were either discharged from the medical center or expired between March 1, 2020, and May 5, 2020, was performed. Patients were stratified according to the receipt of tocilizumab for cytokine storm and matched to controls using propensity scores. The primary outcome was in-hospital mortality. A total of 274 patients meeting inclusion and exclusion criteria were identified and 132 patients were included in the matched dataset (tocilizumab = 66; no tocilizumab = 66). Approximately 73% of the patients were male. Hypertension (55%), diabetes mellitus (31%), and chronic pulmonary disease (15%) were the most common comorbidities present. There were 18 deaths (27.3%) in the tocilizumab group and 18 deaths (27.3%) in the no tocilizumab group (odds ratio, 1.0; 95% confidence interval, 0.465 – 2.151; p = 1.00). Advanced age, history of myocardial infarction, dementia, chronic pulmonary disease, heart failure, and malignancy were significantly more common in patients who died. The current analysis does not support the use of tocilizumab for the management of cytokine storm in patients with COVID-19. Use of this therapeutic agent should be limited to the context of a clinical trial until more evidence is available. url: https://www.ncbi.nlm.nih.gov/pubmed/33154452/ doi: 10.1038/s41598-020-76187-y id: cord-351825-fdog73g2 author: Tsai, Cheng-Yu title: A Novel Non-contact Self-Injection-Locked Radar for Vital Sign Sensing and Body Movement Monitoring in COVID-19 Isolation Ward date: 2020-08-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The outbreak of Coronavirus disease (COVID-19) pandemic has become the most serious global health issue. Isolation policy in hospitals is one of the most crucial protocols to prevent nosocomial infection of COVID-19. It is important to monitor and assess the physical conditions of the patients in isolation. METHODS: Our institution has installed the novel non-contact wireless sensor for vital sign sensing and body movement monitoring for patients in COVID-19 isolation ward. RESULTS: We have collected and compared data between the radar record with the nurse’s handover record of two patients, one recorded for 13 days and the other recorded for 5 days. The P value by Fisher’s exact test were 0.139 (temperature, P > 0.05) and 0.292 (heart beat rate, P > 0.05) respectively. CONCLUSIONS: This is the first report about the application experience of this equipment. Therefore we attempted to share the experience and try to apply this equipment in COVID-19 patients in future to offer the more reliable and safe policy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10916-020-01637-z) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s10916-020-01637-z doi: 10.1007/s10916-020-01637-z id: cord-303880-zv4nbz9p author: Tsikala Vafea, Maria title: Emerging Technologies for Use in the Study, Diagnosis, and Treatment of Patients with COVID-19 date: 2020-06-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The COVID-19 pandemic has caused an unprecedented health and economic worldwide crisis. Innovative solutions are imperative given limited resources and immediate need for medical supplies, healthcare support and treatments. AIM: The purpose of this review is to summarize emerging technologies being implemented in the study, diagnosis, and treatment of COVID-19. RESULTS: Key focus areas include the applications of artificial intelligence, the use of Big Data and Internet of Things, the importance of mathematical modeling for predictions, utilization of technology for community screening, the use of nanotechnology for treatment and vaccine development, the utility of telemedicine, the implementation of 3D-printing to manage new demands and the potential of robotics. CONCLUSION: The review concludes by highlighting the need for collaboration in the scientific community with open sharing of knowledge, tools, and expertise. url: https://www.ncbi.nlm.nih.gov/pubmed/32837582/ doi: 10.1007/s12195-020-00629-w id: cord-011875-ga0dzj3v author: Tsolaki, Vasiliki title: Are Patients with COVID-19 Dying of or with Cardiac Injury? date: 2020-07-15 words: 1306.0 sentences: 79.0 pages: flesch: 44.0 cache: ./cache/cord-011875-ga0dzj3v.txt txt: ./txt/cord-011875-ga0dzj3v.txt summary: Indeed, they quote a sentence in which Dr. Laghi and I say that physicians do not initiate mechanical ventilation consequent to "slotting a patient into a particular diagnostic pigeonhole." (2) Dr. Modesto-Alapont and colleagues claim that the Berlin definition enhances the ability to make a precise diagnosis of acute respiratory distress syndrome (ARDS) in patients with coronavirus disease (COVID-19). Cardiac involvement probably complicates severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients, but the true incidence (considering specific echocardiographic findings) and the attributable mortality are aspects not yet well clarified. Very few reports have used echocardiographic criteria beyond biomarkers to diagnose cardiac injury, but none have differentiated between myocarditis, cardiomyopathy (stress or septic), ACS, and acute heart failure in the era of COVID-19. In a recent report involving 416 hospitalized patients from Wuhan, 19.7% presented with "acute myocardial injury." The diagnosis relied on increased cardiac biomarker (hypersensitive troponin I) levels, regardless of the electrocardiographic and echocardiographic findings (3). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365367/ doi: 10.1164/rccm.202004-1083le id: cord-349396-a6zyioc1 author: Tsurumi, Amy title: Multi-biomarker Prediction Models for Multiple Infection Episodes Following Blunt Trauma date: 2020-10-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe trauma predisposes patients to multiple independent infection episodes (MIIE), leading to augmented morbidity and mortality. We developed a method to identify increased MIIE risk before clinical signs appear, which is fundamentally different from existing approaches entailing infections’ detection after their establishment. Applying machine learning algorithms to genome-wide transcriptome data from 128 adult blunt trauma patients’ (42 MIIE cases and 85 non-cases) leukocytes collected ≤48 hours of injury and ≥3 days before any infection, we constructed a 15-transcript and a 26-transcript multi-biomarker panel model with the least absolute shrinkage and selection operator (LASSO) and Elastic Net, respectively, which accurately predicted MIIE (AUROC [95% CI]: 0.90 [0.84-0.96] and 0.92 [0.86-0.96]), and significantly outperformed clinical models. Gene Ontology and network analyses found various pathways to be relevant. External validation found our model to be generalizable. Our unique precision medicine approach can be applied to a wide range of patient populations and outcomes. url: https://doi.org/10.1016/j.isci.2020.101659 doi: 10.1016/j.isci.2020.101659 id: cord-332233-01rdlf8l author: Tully, Thomas N. title: CHAPTER 12 MICE AND RATS date: 2009-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Publisher Summary This chapter focuses on mice and rats, and provides detailed information that may be useful for veterinarians treating these animals. Mice are continuous, polyestrous rodents that should be bred in polygamous or monogamous setups because of the males' aggressive territoriality behavior. When breeding mice that have been housed in a polygamous ratio, there may be one male with two to six females. Females are removed from a polygamous cage before parturition, whereas the monogamous pair is maintained together with the young until weaning. Mice are maintained in environments that are similar to other small rodents but require a thorough cleaning of their cage more often because of their malodorous urine. Ventilation is essential for small rodent housing to prevent irritation of the respiratory tract from ammonia vapors generated by urine. Quarantining is important when a new animal is being introduced into a setting in which there is an established group. As with other animals, a 30-day quarantine period is recommended, along with a physical examination and fecal parasite check. To maintain oversight of breeding animals' health and reduce the exposure of young animals to infectious disease and parasites, routine screening of representative animals within the colony is recommended. In very large colonies, special caging, food, and water may be necessary to prevent exposure to disease organisms. url: https://www.sciencedirect.com/science/article/pii/B9781416001195500159 doi: 10.1016/b978-141600119-5.50015-9 id: cord-265052-hfuvm1oh author: Turan, Çağrı title: Change of the diagnostic distribution in applicants to dermatology after COVID ‐19 pandemic: What it whispers to us? date: 2020-06-12 words: 4090.0 sentences: 237.0 pages: flesch: 55.0 cache: ./cache/cord-265052-hfuvm1oh.txt txt: ./txt/cord-265052-hfuvm1oh.txt summary: Before and after COVID-19, the diagnostic distribution of patients applied to the dermatology outpatient clinics for three periods consisting of 4-weeks was as in Table 2 . Apart from this, the diagnoses of those who applied to the outpatient clinic more than once during this period were as follows in order of frequency: anogenital warts (n = 19/56, 33.9%), verruca vulgaris (59/365, 16.2%), scabies (17/180, 9.4%), psoriasis (11/140,7 .9%), idiopathic generalized pruritus (17/315, 5.4%), urticaria/angioedema (20/394, 5.1%), atopic dermatitis (14/308, 4.5%), bacterial skin/mucosa diseases (10/268, 3.7%), superficial fungal skin/nail infections (15/503, 3.0%). After the COVID-19 pandemic, which rapidly affected the whole world, there were significant changes in the application to outpatient clinics due to reasons such as measures, call to "stay at home", and panic in the community. In our study, we found a significant increase in the frequency of diagnoses such as idiopathic generalized pruritus, pityriasis rosea, alopecia areata, bacterial skin/mucosa diseases, and zona zoster/post-zoster neuralgia after COVID-19. abstract: We aim to evaluate the change in the diagnostic spectrum in dermatology outpatient applications compared to before COVID‐19. All patients were enrolled from the Department of Dermatology between February 12 and May 8, 2020, the duration of 4 weeks before COVID‐19 and eight weeks after were analyzed in 3 parts consisting of 4 weeks. Data obtained from the database such as age, gender, diagnoses were anonymized. Repeated applications with the same diagnosis in ten days after the first presentation were ignored. Compared to the pre‐outbreak, there was a 3.5‐fold decrease in dermatology applications in the first month after COVID‐19 and an 8.8‐fold in the second month. We found a significant increase in the frequency of diagnoses such as generalized pruritus, pityriasis rosea, alopecia areata, bacterial skin/mucosa diseases, and zona zoster after COVID‐19. The frequency declined in diseases such as verruca vulgaris, hyperpigmentation, skin tag, melanocytic nevus, seborrheic keratosis/solar lentigo. It has been found that the frequencies of most diseases, including acne (⁓25% of patients), did not change. We think that many factors, such as affecting the quality of life, risk perception, increased stress burden may cause a change in the diagnostic distribution of the dermatology applications. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1111/dth.13804 doi: 10.1111/dth.13804 id: cord-275440-fl4dsu7d author: Turnidge, John title: Responsible Prescribing for Upper Respiratory Tract Infections date: 2012-10-10 words: 6473.0 sentences: 375.0 pages: flesch: 45.0 cache: ./cache/cord-275440-fl4dsu7d.txt txt: ./txt/cord-275440-fl4dsu7d.txt summary: Generic strategies, including eliciting patient expectations, avoiding the term ''just a virus'', providing a value-for-money consultation, providing verbal and written information, empowering patients, conditional prescribing, directed education campaigns, and emphasis on symptomatic treatments, should be used as well as discussion of alternative medicines when relevant. Detailed strategies for acute sinusitis have not been worked out but restricting antibacterial prescribing to certain clinical complexes is currently recommended by several authorities because of the high natural resolution rate. Given that resistance to antibacterials in the common bacterial respiratory pathogens, especially Streptococcus pneumoniae, is increasing worldwide, [5] it is time to critically review prescribing practices in patients with URTI and find methods for not prescribing antibacterials to patients who are unlikely to benefit. [27] There is a difference between the bacteriology of previously untreated acute otitis media and that of patients with persistent infection, [28] resistant bacteria being more common in the latter. abstract: Upper respiratory tract infections (URTIs) are responsible for a large amount of community antibacterial use worldwide. Recent systematic reviews have demonstrated that most URTIs resolve naturally, even when bacteria are the cause. The high consumer expectation for antibacterials in URTIs requires intervention by the general practitioner and a number of useful strategies have been developed. Generic strategies, including eliciting patient expectations, avoiding the term ‘just a virus’, providing a value-for-money consultation, providing verbal and written information, empowering patients, conditional prescribing, directed education campaigns, and emphasis on symptomatic treatments, should be used as well as discussion of alternative medicines when relevant. The various conditions have differing rates of bacterial infection and require different approaches. For acute rhinitis, laryngitis and tracheitis, viruses are the only cause and, therefore, antibacterials are never required. In acute sore throat (pharyngitis) Streptococcus pyogenes is the only important bacterial cause. A scoring system can help to increase the likelihood of distinguishing a streptococcal as opposed to viral infection, or alternatively patients should be given antibacterials only if certain conditions are fulfilled. Strategies for treating acute otitis media vary in different countries. Most favour the strategy of prescribing antibacterials only when certain criteria are fulfilled, delaying antibacterial prescribing for at least 24 hours. In otitis media with effusion, on the other hand, there is no primary role for antibacterials, as the condition resolves naturally in almost all patients aged >3 months. Detailed strategies for acute sinusitis have not been worked out but restricting antibacterial prescribing to certain clinical complexes is currently recommended by several authorities because of the high natural resolution rate. url: https://www.ncbi.nlm.nih.gov/pubmed/11735633/ doi: 10.2165/00003495-200161140-00004 id: cord-290771-18dj37dj author: Tzeng, Ching-Wei D. title: Cancer Surgery Scheduling During and After the COVID-19 First Wave: The MD Anderson Cancer Center Experience date: 2020-05-18 words: 4865.0 sentences: 225.0 pages: flesch: 37.0 cache: ./cache/cord-290771-18dj37dj.txt txt: ./txt/cord-290771-18dj37dj.txt summary: CONCLUSIONS: Cancer surgeons should continue to use their oncologic knowledge to determine the window of opportunity for each surgical procedure, based on tumor biology, preoperative treatment sequencing, and response to systemic therapy, to safely guide patients through this cautious recovery phase. Total surgical case volume by week during early COVID-19 response, in which MD Anderson Cancer Center implemented goals to create a ''''moat'''' around hospitalized patients, to reduce workforce and visitor traffic, and to limit ''''elective'''' cases. Because the Department of Surgical Oncology and MD Anderson Cancer Center have traditionally favored neoadjuvant therapy for many solid tumors, we strategically initiated or continued this treatment sequencing when possible to postpone surgery to beyond the late April peak of COVID-19 incidence in the Houston area. abstract: OBJECTIVE: To summarize the multi-specialty strategy and initial guidelines of a Case Review Committee in triaging oncologic surgery procedures in a large Comprehensive Cancer Center and to outline current steps moving forward after the initial wave. SUMMARY OF BACKGROUND DATA: The impetus for strategic rescheduling of operations is multifactorial and includes our societal responsibility to minimize COVID-19 exposure risk and propagation among patients, the healthcare workforce, and our community at large. Strategic rescheduling is also driven by the need to preserve limited resources. As many states have already or are considering to re-open and relax stay-at-home orders, there remains a continued need for careful surgical scheduling because we must face the reality that we will need to co-exist with COVID-19 for months, if not years. METHODS: The quality officers, chairs, and leadership of the 9 surgical departments in our Division of Surgery provide specialty-specific approaches to appropriately triage patients. RESULTS: We present the strategic approach for surgical rescheduling during and immediately after the COVID-19 first wave for the 9 departments in the Division of Surgery at The University of Texas MD Anderson Cancer Center in Houston, Texas. CONCLUSIONS: Cancer surgeons should continue to use their oncologic knowledge to determine the window of opportunity for each surgical procedure, based on tumor biology, preoperative treatment sequencing, and response to systemic therapy, to safely guide patients through this cautious recovery phase. url: https://doi.org/10.1097/sla.0000000000004092 doi: 10.1097/sla.0000000000004092 id: cord-268952-3j43p9j3 author: Ueda Oshima, Masumi title: Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach date: 2020-09-26 words: 3636.0 sentences: 154.0 pages: flesch: 37.0 cache: ./cache/cord-268952-3j43p9j3.txt txt: ./txt/cord-268952-3j43p9j3.txt summary: Situated in the initial epicenter of the pandemic, the Blood and Marrow Transplant (BMT) Program at Fred Hutchinson Cancer Research Center (Fred Hutch)/Seattle Cancer Care Alliance (SCCA) was at the forefront of delivering care to transplant patients during the surge of this public health crisis. In early March 2020 when community transmissions resulted in a steep increase of COVID-19 cases in Washington state, the individual risk for hematopoietic cell transplant (HCT) patients who acquired the infection was unknown. In early March 2020, the Institute for Health Metrics and Evaluation at the UW predicted that the COVID-19-driven demand for healthcare resources including acute and intensive care hospital beds and ventilators might exceed the available supply in Washington state and particularly in our region [6] . Once a COVID-19 vaccine is available, vaccination approaches for the posttransplant period in immunosuppressed patients, vaccination of caregivers, family, and clinical staff, and even assessing potential benefits of vaccinating donors prior to stem cell donation will have to be determined. abstract: On January 20, 2020, the first patient with coronavirus disease 2019 (COVID-19) in the United States of America was diagnosed in Washington state, which subsequently experienced rapidly increasing numbers of COVID-19 cases, hospitalizations, and deaths. This placed the Seattle Blood and Marrow Transplant Program at Fred Hutchinson Cancer Research Center (Fred Hutch) in the national epicenter of this pandemic. Here, we summarize the experience gained during our rapid response to the COVID-19 pandemic. Our efforts were aimed at safely performing urgent and potentially life-saving stem cell transplants in the setting of pandemic-related stresses on healthcare resources and shelter-in-place public health measures. We describe the unique circumstances and challenges encountered, the current state of the program amidst evolving COVID-19 cases in our community, and the guiding principles for recovery. We also estimate the collateral impact of directing clinical resources toward COVID-19-related care on cancer patients in need of stem cell transplantation. Although our experience was influenced by specific regional and institutional factors, it may help inform how transplant programs respond to COVID-19 and future pandemics. url: https://doi.org/10.1038/s41409-020-01068-x doi: 10.1038/s41409-020-01068-x id: cord-035026-2qcsfd87 author: Ugwueze, Chidiebere V. title: COVID-19 and Diabetes Mellitus: The Link and Clinical Implications date: 2020-10-23 words: 5413.0 sentences: 329.0 pages: flesch: 44.0 cache: ./cache/cord-035026-2qcsfd87.txt txt: ./txt/cord-035026-2qcsfd87.txt summary: The effect of glucocorticoids and catecholamines, invasion of the pancreatic islet cells, drugs used in the treatment of COVID-19, and the lockdown policy may impact negatively on glycemic control of diabetic patients. [40] showed that the clinical outcomes in COVID-19-positive patients with coexisting diabetes and hypertension who use ACE inhibitor or angiotensin II receptor blocker were comparable to those not using the drugs. A clinical trial (NCT04318418) was designed to determine the effect of ACE inhibitors and angiotensin II type 1 receptor blockers on the severity of COVID-19 infection [41] . Some authors have considered the rapidity of worsening glycemic control in stable diabetic patients with CO-VID-19 requiring the use of high insulin dose and suggested the possibility of pancreatic invasion by the SARS-CoV-2 [57, 58] . Once the entry of the virus is established, there is a downregulation of ACE2 receptor and a corresponding Ugwueze/Ezeokpo/Nnolim/Agim/ Anikpo/Onyekachi Dubai Diabetes Endocrinol J 6 DOI: 10.1159/000511354 activation of renin-angiotensin-aldosterone system, which is responsible for the cardiac and pulmonary complications of COVID-19 infection [75] . abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a pandemic viral infection that has ravaged the world in recent times, and the associated morbidity and mortality have been much more pronounced in those with noncommunicable disease. Diabetes mellitus is one of commonest noncommunicable diseases associated with worsening clinical status in COVID-19 patients. SUMMARY: The aim of this review was to evaluate the receptors and pathogenetic link between diabetes and COVID-19. Both disease conditions involve inflammation with the release of inflammatory markers. The roles of angiotensin-converting enzyme molecule and dipeptidyl peptidase were explored to show their involvement in COVID-19 and diabetes. Pathogenetic mechanisms such as impaired immunity, microangiopathy, and glycemic variability may explain the effect of diabetes on recovery of COVID-19 patients. The effect of glucocorticoids and catecholamines, invasion of the pancreatic islet cells, drugs used in the treatment of COVID-19, and the lockdown policy may impact negatively on glycemic control of diabetic patients. The outcome studies between diabetic and nondiabetic patients with COVID-19 were also reviewed. Some drug trials are still ongoing to determine the suitability or otherwise of some drugs used in diabetic patients with COVID-19, such as dapagliflozin trial and linagliptin trial. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649685/ doi: 10.1159/000511354 id: cord-286293-f5qg7vcz author: Ullah, Waqas title: COVID-19 complicated by Acute Pulmonary Embolism and Right-Sided Heart Failure date: 2020-04-17 words: 1094.0 sentences: 78.0 pages: flesch: 47.0 cache: ./cache/cord-286293-f5qg7vcz.txt txt: ./txt/cord-286293-f5qg7vcz.txt summary: Since the end of December 2019, when the first cases of novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) were detected in Wuhan, China, the disease has spread exponentially. [2] In up to 15% of patients, the natural course of the disease is complicated by severe interstitial pneumonia, which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure including acute kidney injury, disseminated intravascular coagulation and death. [2] To our knowledge, there have been no reported cases of COVID-19 complicated by massive pulmonary embolism and right-sided heart failure. [4] A higher risk of vessel thrombosis has been correlated with the severity of the disease and multiorgan involvement, leading support to the argument of therapeutic anticoagulation of COVID-19 patients with elevated d-dimer levels. In the present case, the patient had elevated CRP and d-dimer levels with no other risk factor for pulmonary embolism, indicating COVID-19 related hypercoagulable state as possible etiology for thrombosis in the pulmonary vasculature. abstract: Abstract A patient with Coronavirus Disease-2019 (COVID-19) developed sudden shortness of breath and hypoxia. She was diagnosed with a massive pulmonary embolism (PE) complicated by right sided heart failure, which was successfully managed conservatively. This marks the first report of COVID-19 induced PE in association with acute heart failure. url: https://www.sciencedirect.com/science/article/pii/S2666084920303673?v=s5 doi: 10.1016/j.jaccas.2020.04.008 id: cord-353180-hbwrzm6s author: Umoren, Rachel A. title: In-Hospital Telehealth Supports Care for Neonatal Patients in Strict Isolation date: 2020-04-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The aim of this study is to determine the feasibility of “in-hospital” inpatient telemedicine within a children's referral hospital to facilitate inpatient care activities such as interprofessional rounding and the provision of supportive services such as lactation consultations to pediatric patients in strict isolation. To test the feasibility of in-hospital video telemedicine, a dedicated telemedicine device was set up in the patient's room. This device and the accompanying Bluetooth stethoscope were used by the health care team located just outside the room for inpatient rounding and consultations from supportive services. Video telemedicine facilitated inpatient care and interactions with support services, reducing the number of health care providers with potential exposure to infection and decreasing personal protective equipment use. In the setting of strict isolation for highly infectious viral illness, telemedicine can be used for inpatient care activities such as interprofessional rounding and provision of supportive services. Key Points: Telehealth supports patient care in isolation. Telehealth reduced health care provider exposures. Telehealth conserves personal protective equipment. url: https://www.ncbi.nlm.nih.gov/pubmed/32268382/ doi: 10.1055/s-0040-1709687 id: cord-010564-7c9h16bi author: Unolt, Marta title: Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition date: 2019-09-02 words: 4682.0 sentences: 274.0 pages: flesch: 44.0 cache: ./cache/cord-010564-7c9h16bi.txt txt: ./txt/cord-010564-7c9h16bi.txt summary: Based on the clinical presentation of these patients and on the recurrent phenotype of the patients with pathogenic variants in the CDC45 gene (Table 1) , reported by Fenwick et al., 5 we further expanded the atypical findings spectrum, to include rare gastrointestinal anomalies, such as intestinal malrotation, imperforate/anteriorly displaced anus and congenital diaphragmatic hernia and short stature (in absence of any endocrine or metabolic cause) and patellar anomalies. 5 identified biallelic pathogenic variants in the CDC45 gene in patients with a recurrent phenotype ( Table 1 ) they reported to be consistent with Meier-Gorlin syndrome (MGS, MIM 224690), a rare autosomal recessive primordial dwarfism disorder, characterized by microtia, short stature, and absent or hypoplastic patellae. Importantly, we suggest that a pathogenic variant in CDC45 should now be considered in every patient with a 22q11.2 deletion who presents with the following findings: craniosynostosis, anorectal anomalies/intestinal malrotation, short stature, upper limb anomalies, and cleft lip and palate. abstract: PURPOSE: The 22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion in humans, with highly variable phenotypic expression. Whereas congenital heart defects, palatal anomalies, immunodeficiency, hypoparathyroidism, and neuropsychiatric conditions are observed in over 50% of patients with 22q11DS, a subset of patients present with additional “atypical” findings such as craniosynostosis and anorectal malformations. Recently, pathogenic variants in the CDC45 (Cell Division Cycle protein 45) gene, located within the LCR22A–LCR22B region of chromosome 22q11.2, were noted to be involved in the pathogenesis of craniosynostosis. METHODS: We performed next-generation sequencing on DNA from 15 patients with 22q11.2DS and atypical phenotypic features such as craniosynostosis, short stature, skeletal differences, and anorectal malformations. RESULTS: We identified four novel rare nonsynonymous variants in CDC45 in 5/15 patients with 22q11.2DS and craniosynostosis and/or other atypical findings. CONCLUSION: This study supports CDC45 as a causative gene in craniosynostosis, as well as a number of other anomalies. We suggest that this association results in a condition independent of Meier–Gorlin syndrome, perhaps representing a novel condition and/or a cause of features associated with Baller–Gerold syndrome. In addition, this work confirms that the phenotypic variability observed in a subset of patients with 22q11.2DS is due to pathogenic variants on the nondeleted chromosome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197230/ doi: 10.1038/s41436-019-0645-4 id: cord-290028-oyd7vzj6 author: Unruh, Mark title: Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis date: 2020-10-20 words: 7668.0 sentences: 339.0 pages: flesch: 45.0 cache: ./cache/cord-290028-oyd7vzj6.txt txt: ./txt/cord-290028-oyd7vzj6.txt summary: This will be accomplished with a randomized controlled trial (RCT) in which 126 participants treated with HD in community-based dialysis facilities with chronic insomnia will be assigned 1:1:1 to telehealth CBT-I, trazodone, or medication placebo, respectively; short-term effectiveness of each treatment arm will be determined at the end of 6-weeks of treatment and long-term effectiveness at 25-weeks. Study design and overview SLEEP-HD is a parallel-group RCT wherein 126 HD patients treated in community-based dialysis facilities in Seattle and Albuquerque will be randomized 1:1:1 over 31 months to 6-week treatment with telehealth Cognitive Behavioral Therapy for Insomnia (CBT-I), trazodone, or medication placebo (Fig. 1) . abstract: BACKGROUND: Patients with end-stage kidney disease (ESKD) treated with hemodialysis (HD) experience many distressing symptoms. One frequently reported symptom is insomnia. There are unique issues about HD treatments and schedules that disrupt regular sleep/wake routines and possibly contribute to the high severity of insomnia. Despite evidence for broad-ranging health effects of insomnia, very few clinical trials have tested the efficacy of treatments for HD patients. Cognitive-behavioral therapy for insomnia (CBT-I) is a recommended first-line therapy but largely inaccessible to HD patients in the United States, partly because they commit considerable amounts of time to thrice-weekly dialysis treatments. Another important reason could be the logistical and reimbursement challenges associated with providing behavioral health care at the dialysis center. CBT-I delivered by telehealth can overcome barriers to access, but its efficacy has never been rigorously tested for these patients. Pharmacotherapy is the most widely used treatment for insomnia; however, some drugs presently used are unsafe as they are associated with a higher risk for death for HD patients (benzodiazepines and zolpidem-like drugs). The efficacy and safety of other medications (trazodone) for the treatment of insomnia has never been tested for patients treated with HD. METHODS: This trial tests the short- and long-term comparative effectiveness of 6-week treatment with telehealth CBT-I, trazodone, or medication placebo. This will be accomplished with a randomized controlled trial (RCT) in which 126 participants treated with HD in community-based dialysis facilities with chronic insomnia will be assigned 1:1:1 to telehealth CBT-I, trazodone, or medication placebo, respectively; short-term effectiveness of each treatment arm will be determined at the end of 6-weeks of treatment and long-term effectiveness at 25-weeks. The primary and secondary patient-reported outcomes will be assessed with computer-based telephone interviewing by research scientists blinded to treatment assignment; additional secondary outcomes will be assessed by participant interview and actigraphy. DISCUSSION: This clinical RCT will provide the first evidence for the comparative effectiveness of two distinct approaches for treating chronic insomnia and other patient-reported outcomes for patients receiving maintenance HD. TRIAL REGISTRATION: NCT03534284 May 23, 2018. SLEEP-HD Protocol Version: 1.3.4 (7/22/2020). url: https://doi.org/10.1186/s12882-020-02107-x doi: 10.1186/s12882-020-02107-x id: cord-345628-a4c46m2w author: Unudurthi, Sathya D. title: Cardiac inflammation in COVID-19: Lessons from heart failure date: 2020-09-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Cardiovascular disease (CVD) is the most common co-morbidity associated with COVID-19 and the fatality rate in COVID-19 patients with CVD is highest compared to other comorbidities, such as hypertension and diabetes. Preliminary data suggest that COVID-19 may also cause or worsen cardiac injury in infected patients through multiple mechanisms such as ‘cytokine storm’, endotheliosis, thrombosis, lymphocytopenia etc. Autopsies of COVID-19 patients reveal an infiltration of inflammatory mononuclear cells in the myocardium, confirming the role of the immune system in mediating cardiovascular damage in response to COVID-19 infection and also suggesting potential causal mechanisms for the development of new cardiac pathologies and/or exacerbation of underlying CVDs in infected patients. In this review, we discuss the potential underlying molecular mechanisms that drive COVID-19-mediated cardiac damage, as well as the short term and expected long-term cardiovascular ramifications of COVID-19 infection in patients. url: https://api.elsevier.com/content/article/pii/S0024320520312352 doi: 10.1016/j.lfs.2020.118482 id: cord-348051-o1hxoasp author: Upadhyaya, Gaurav K. title: Challenges and strategies in management of osteoporosis and fragility fracture care during COVID-19 pandemic date: 2020-06-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: COVID-19 has resulted in restriction of face to face consultations and mechanisms to access health care. Osteoporosis and fragility fractures forms a significant proportion of adult trauma and orthopaedic workload even during the pandemic. AIMS: We assess the challenges and strategies used in the management of osteoporosis and fragility fracture care during the COVID-19 pandemic. METHODS: We have done a comprehensive review of the literature using suitable keywords on the search engines of PubMed, SCOPUS, Google Scholar and Research Gate in the first week of May 2020 on developments and guidance during the current COVID-19 pandemic. RESULTS: Osteoporosis and fragility fractures management has been hampered by lock down and infection transmission strategies used to contain the COVID-19 pandemic. Access to diagnostic tests, treatment facilities with the need to use clinical and prediction tools to guide management Telemedicine has an evolving role. CONCLUSION: Osteoporosis and fragility fractures in elderly individuals pose a real challenge for an appropriate diagnosis and management, during the COVID-19 pandemic. A clinical decision along with use of clinical prediction tools for osteoporosis should be used to direct treatment. Obligatory fractures such as hip fractures require operative intervention. Non-obligatory fractures such as distal radius fractures can be managed conservatively with use of telemedicine applications in monitoring both types of patients. url: https://api.elsevier.com/content/article/pii/S0972978X20302014 doi: 10.1016/j.jor.2020.06.001 id: cord-011836-zib8wkm2 author: Urman, Jesús M. title: Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach date: 2020-06-21 words: 13598.0 sentences: 626.0 pages: flesch: 44.0 cache: ./cache/cord-011836-zib8wkm2.txt txt: ./txt/cord-011836-zib8wkm2.txt summary: We performed metabolomic and proteomic analyses of bile from patients with benign (n = 36) and malignant conditions, CCA (n = 36) or PDAC (n = 57), undergoing endoscopic retrograde cholangiopancreatography with the aim of characterizing bile composition in biliopancreatic disease and identifying biomarkers for the differential diagnosis of biliary strictures. Alterations in BA In the present study we have performed parallel metabolomic and proteomic analyses of human bile from patients with benign and malignant (CCA and PDAC) biliary stenoses. Therefore, using a novel approach, we have combined metabolomic and proteomic measurements with machine intelligence modeling and synthetic data generation [51, 53, 54] to identify molecular patterns that can discriminate malignant from benign biliary strictures. An equivalent analysis was performed with the proteomic data obtained from a different set of bile samples from control and patients with PDAC-related malignant stenoses. An equivalent analysis was performed with the proteomic data obtained from a different set of bile samples from control and patients with PDAC-related malignant stenoses. abstract: Cholangiocarcinoma (CCA) and pancreatic adenocarcinoma (PDAC) may lead to the development of extrahepatic obstructive cholestasis. However, biliary stenoses can also be caused by benign conditions, and the identification of their etiology still remains a clinical challenge. We performed metabolomic and proteomic analyses of bile from patients with benign (n = 36) and malignant conditions, CCA (n = 36) or PDAC (n = 57), undergoing endoscopic retrograde cholangiopancreatography with the aim of characterizing bile composition in biliopancreatic disease and identifying biomarkers for the differential diagnosis of biliary strictures. Comprehensive analyses of lipids, bile acids and small molecules were carried out using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy ((1)H-NMR) in all patients. MS analysis of bile proteome was performed in five patients per group. We implemented artificial intelligence tools for the selection of biomarkers and algorithms with predictive capacity. Our machine-learning pipeline included the generation of synthetic data with properties of real data, the selection of potential biomarkers (metabolites or proteins) and their analysis with neural networks (NN). Selected biomarkers were then validated with real data. We identified panels of lipids (n = 10) and proteins (n = 5) that when analyzed with NN algorithms discriminated between patients with and without cancer with an unprecedented accuracy. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352944/ doi: 10.3390/cancers12061644 id: cord-311673-z4hkw17g author: Uzzan, Mathieu title: Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - lung axis hypothesis date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Consistent observations report increased severity of SARS-CoV-2 infection in overweight men with cardiovascular factors. As the visceral fat possesses an intense immune activity, is involved in metabolic syndrome and is at the crossroad between the intestines, the systemic circulation and the lung, we hypothesized that it plays a major role in severe forms of SARS-CoV-2 infection. SARS-CoV2 presents the ability to infect epithelial cells of the respiratory tract as well as the intestinal tract. Several factors may increase intestinal permeability including, direct enterocyte damage by SARS-CoV2, systemic inflammatory response syndrome (SIRS) and epithelial ischemia secondary to SARS-CoV2- associated endothelial dysfunction. This increase permeability further leads to translocation of microbial components such as MAMPS (microbial-associated molecular pattern), triggering an inflammatory immune response by TLR-expressing cells of the mesentery fat (mostly macrophages and adipocytes). The pro-inflammatory cytokines produced by the mesentery fat mediates systemic inflammation and aggravate acute respiratory distress syndrome (ARDS) through the mesenteric lymph drainage. url: https://www.sciencedirect.com/science/article/pii/S0306987720316662?v=s5 doi: 10.1016/j.mehy.2020.110023 id: cord-253077-61fmul8c author: Vabret, Nicolas title: Immunology of COVID-19: current state of the science date: 2020-05-06 words: 20227.0 sentences: 1120.0 pages: flesch: 45.0 cache: ./cache/cord-253077-61fmul8c.txt txt: ./txt/cord-253077-61fmul8c.txt summary: Lastly, Nonhuman primate (NHP) studies and patient data on SARS-CoV-1 have also shown that virus spike-specific IgG responses can exacerbate acute lung injury due to repolarization of alveolar macrophages into pro-inflammatory phenotypes and enhanced recruitment of inflammatory monocyte via CCL2 and IL-8 (Clay et al., 2012; Liu et al., 2019) . Collectively, these data suggest that cross-talk with monocytes might impair NK cell recognition and killing of SARS-CoV-2infected cells, and antibodies targeting IL-6 and TNF-signaling may benefit enhanced NK cell functions in COVID-19 patients ( Figure 2 ). However, these CD4 T cells lacked phenotypic markers of activation and were specific for C-terminal S protein epitopes that are highly similar to endemic human coronaviruses, suggesting that crossreactive CD4 memory T cells in some populations (e.g., children and younger patients that experience a higher incidence of hCoV infections) may be recruited into an amplified primary SARS-CoV-2-specific response (Braun et al., 2020) . abstract: Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection. url: https://www.ncbi.nlm.nih.gov/pubmed/32505227/ doi: 10.1016/j.immuni.2020.05.002 id: cord-332774-t5untewz author: Vaccaro, Alexander R. title: Practice Management During the COVID-19 Pandemic date: 2020-04-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: On March 14, 2020, the Surgeon General of the United States urged a widespread cessation of all elective surgery across the country. The suddenness of this mandate and the concomitant spread of the COVID-19 virus left many hospital systems, orthopaedic practices, and patients with notable anxiety and confusion as to the near, intermediate, and long-term future of our healthcare system. As with most businesses in the United States during this time, many orthopaedic practices have been emotionally and fiscally devastated because of this crisis. Furthermore, this pandemic is occurring at a time where small and midsized orthopaedic groups are already struggling to cover practice overhead and to maintain autonomy from larger health systems. It is anticipated that many groups will experience financial demise, leading to substantial global consolidation. Because the authors represent some of the larger musculoskeletal multispecialty groups in the country, we are uniquely positioned to provide a framework with recommendations to best weather the ensuing months. We think these recommendations will allow providers and their staff to return to an infrastructure that can adjust immediately to the pent-up healthcare demand that may occur after the COVID-19 pandemic. In this editorial, we address practice finances, staffing, telehealth, operational plans after the crisis, and ethical considerations. url: https://www.ncbi.nlm.nih.gov/pubmed/32287086/ doi: 10.5435/jaaos-d-20-00379 id: cord-327370-zo0n8wf6 author: Vadukul, Prakash title: Massive pulmonary embolism following recovery from COVID-19 infection: inflammation, thrombosis and the role of extended thromboprophylaxis date: 2020-09-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 is the infectious disease caused by a recently discovered SARS-CoV-2. Following an initial outbreak in December 2019 in Wuhan, China, the virus has spread globally culminating in the WHO declaring a pandemic on 11 March 2020. We present the case of a patient with an initial presentation of COVID-19 pneumonitis requiring mechanical ventilation for nearly 2 weeks and total admission time of 3 weeks. She was given prophylactic dose anticoagulation according to hospital protocol during this time. Following a week at home, she was readmitted with acute massive pulmonary embolism with severe respiratory and cardiac failure, representing the first such case in the literature. url: https://doi.org/10.1136/bcr-2020-238168 doi: 10.1136/bcr-2020-238168 id: cord-288552-7lp07v5i author: Vahedi, Ensieh title: The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study date: 2020-06-19 words: 4914.0 sentences: 232.0 pages: flesch: 40.0 cache: ./cache/cord-288552-7lp07v5i.txt txt: ./txt/cord-288552-7lp07v5i.txt summary: CONCLUSION: This study revealed the beneficial effect of the short-term use of low-dose prednisolone in combination with azithromycin, naproxen and lopinavir/ritonavir (regimen I), in decreasing ALOS compared to regimen II. Therefore, the present study aimed to evaluate short-term effects of regimen I (azithromycin, prednisolone, naproxen, and lopinavir/ritonavir) in group I patients in comparison to regimen II (meropenem, levofloxacin, vancomycin, hydroxychloroquine, and oseltamivir) in group II patients in the treatment of COVID-19 infection. The patients'' medical information including demographic data, COVID-19 test using a real-time RT-PCR via throatswab specimens, clinical features, routine laboratory tests, chest CT scans (before and after discharge) according to the WHO interim guidance [23] , treatment measures, comorbidities and data on the outcomes were extracted independently by two physicians through a standard case record form provided by the hospital. abstract: BACKGROUND: There is no identified pharmacological therapy for COVID-19 patients, where potential therapeutic strategies are underway to determine effective therapy under such unprecedented pandemic. Therefore, combination therapies may have the potential of alleviating the patient’s outcome. This study aimed at comparing the efficacy of two different combination regimens in improving outcomes of patients infected by novel coronavirus (COVID-19). METHODS: This is a single centered, retrospective, observational study of 60 laboratory-confirmed COVID-19 positive inpatients (≥18 years old) at two wards of the Baqiyatallah Hospital, Tehran, Iran. Patient’s data including clinical and laboratory parameters were recorded. According to the drug regimen, the patients were divided into two groups; group I who received regimen I consisting azithromycin, prednisolone, naproxen, and lopinavir/ritonavir and group II who received regimen II including meropenem, levofloxacin, vancomycin, hydroxychloroquine, and oseltamivir. RESULTS: The oxygen saturation (SpO2) and temperature were positively changed in patients receiving regimen I compared to regimen II (P = 0.013 and P = 0.012, respectively). The serum level of C-reactive protein (CRP) changed positively in group I (P < 0.001). Although there was a significant difference in platelets between both groups (75.44 vs 51.62, P < 0.001), their change did not clinically differ between two groups. The findings indicated a significant difference of the average length of stay in hospitals (ALOS) between two groups, where the patients under regimen I showed a shorter ALOS (6.97 vs 9.93, P = 0.001). CONCLUSION: This study revealed the beneficial effect of the short-term use of low-dose prednisolone in combination with azithromycin, naproxen and lopinavir/ritonavir (regimen I), in decreasing ALOS compared to regimen II. Since there is still lack of evidence for safety of this regimen, further investigation in our ongoing follow-up to deal with COVID-19 pneumonia is underway. [Figure: see text] url: https://doi.org/10.1007/s40199-020-00353-w doi: 10.1007/s40199-020-00353-w id: cord-277535-u283k70i author: Vaja, Rakesh title: Drugs and the liver date: 2020-09-22 words: 4012.0 sentences: 239.0 pages: flesch: 49.0 cache: ./cache/cord-277535-u283k70i.txt txt: ./txt/cord-277535-u283k70i.txt summary: Additionally, drugs can also modify how the liver functions and cause dysfunction or even failure of the organ both by a direct effect on the liver or by alteration in liver blood flow. Furthermore, once a patient has been recognized to be suffering with liver dysfunction or failure drug choice and dosing regime will need to be rationalized. After reading this article you should: C understand the mechanisms of drug metabolism by the liver C have an appreciation of alterations to drug choice and dosing regimens in patients with liver disease due to their altered pharmacokinetics C know the management of a patient with paracetamol overdose There are many different isoforms of CYP450, classified according to their amino acid sequencing into families, subfamilies and individual genes. NSAIDS are contraindicated for systemic use in most liver disease patients, because of increased bioavalibilty, the high risk of precipitating gastrointestinal bleeding and renal failure. abstract: The liver is a major organ with multiple functions. A number of drugs are metabolized by the liver during phase 1 and 2 reactions which include complex processes involving cytochrome P450 enzymes. Genetic and acquired variability in cytochrome P450 activity may have profound effects on pharmacokinetics. Additionally, drugs can also modify how the liver functions and cause dysfunction or even failure of the organ both by a direct effect on the liver or by alteration in liver blood flow. It is important to recognize the signs and symptoms of liver failure in patients and identify possible causes including drug interactions. Furthermore, once a patient has been recognized to be suffering with liver dysfunction or failure drug choice and dosing regime will need to be rationalized. Paracetamol overdose can have severe and life threatening consequences for patients due to its effect on liver function. It is the leading cause of acute liver failure in the UK, 1 Correct and early management is crucial and will be discussed within this article. url: https://api.elsevier.com/content/article/pii/S1472029920301399 doi: 10.1016/j.mpaic.2020.07.001 id: cord-032244-s7t5u9lf author: Valente, Serafina title: ANMCO POSITION PAPER: Considerations on in-hospital cardiological consultations and cardiology outpatient clinics during the COVID-19 pandemic date: 2020-08-27 words: 1511.0 sentences: 87.0 pages: flesch: 39.0 cache: ./cache/cord-032244-s7t5u9lf.txt txt: ./txt/cord-032244-s7t5u9lf.txt summary: The aim of this document is to propose algorithms for the management of cardiovascular diseases during COVID-19 emergency with the objective of providing patients with optimal care, minimizing contagion risk and appropriately managing personal protective equipment. 9, 10 The objective of this document is to propose management algorithms for cardiovascular disease during the COVID-19 emergency, in order to optimize cardiological assistance for the benefit of patients by minimizing the possibility of contagion, safeguarding healthcare personnel, and rationalizing the use of personal protective equipment (PPE). • angina pectoris • heart failure • arrhythmia In the case of a suspected COVID-19 patient, it is always necessary to try to postpone the medical exam or the appointment (if a cardiac patient cannot wait, refer them to the emergency room which has appropriate access points and safety procedures in place) or manage with the available PPE according to the risk of contagion following specific safety procedures, remembering to disinfect spaces and equipment after the exam/appointment according to local protocols. abstract: Infections by SARS CoV2 - COVID-19 have become in a short time a worldwide health emergency. Due to cardiovascular implications of COVID-19 and to very frequent previous cardiovascular disorders of COVID-19 patients, it is presently crucial that Cardiologists are fully aware of COVID-19 related epidemiological, pathophysiological and therapeutic problems, in order to manage at best the present emergency by appropriate protocols developed on the basis of the competences acquired and shared on the field. The aim of this document is to propose algorithms for the management of cardiovascular diseases during COVID-19 emergency with the objective of providing patients with optimal care, minimizing contagion risk and appropriately managing personal protective equipment. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499600/ doi: 10.1093/eurheartj/suaa112 id: cord-031256-4mxt501d author: Van Der Poorten, Marie-Line M. title: Non-irritating skin test concentrations for ceftazidime and aztreonam in patients with a documented beta-lactam allergy. date: 2020-09-01 words: 1724.0 sentences: 121.0 pages: flesch: 60.0 cache: ./cache/cord-031256-4mxt501d.txt txt: ./txt/cord-031256-4mxt501d.txt summary: Our study shows that the maximal non-irritant concentration (NIC) for ceftazidime and for aztreonam 32 is as high as 20 mg/mL for immediate readings of intradermal skin tests (IDT). (1) 42 This study aims at assessing the NIC for ceftazidime, a third generation cephalosporin, and 43 aztreonam, a synthetic monobactam, both potential safe alternative β-LABs in patients with a 44 documented hypersensitivity reaction to penicillin G, amoxicillin (+/-clavulanic acid) or cefazolin. Diagnosis of their Penicillin G, amoxicillin (+/-clavulanic acid) or cefazolin 52 hypersensitivity was based upon a history complemented by positive STs (immediate and delayed 53 readings), drug-reactive sIgE antibodies, a sIgE-to-tIgE ratio ≥ 0.002, or a graded drug challenge (DC). Our results show that the NICs for ceftazidime and aztreonam, as recommended in the ENDA/EAACI 102 Drug Allergy Interest Group position paper (3) and its update by Romano et al (8) , can further benefit 103 from an assessment in patients who experienced an IDHR or NIDHR to penicillin G, amoxicillin (+/-104 clavulanic acid) or an IDHR to cefazolin. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462539/ doi: 10.1016/j.jaip.2020.08.031 id: cord-302215-sqrbj5r4 author: Vanden Eynde, Jean Jacques title: COVID-19: An Update about the Discovery Clinical Trial date: 2020-05-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Finding efficacious and safe treatments for COVID-19 emerges as a crucial need in order to control the spread of the pandemic. Whereas plasma therapy attracts much interest, the European project Discovery focuses on the potentialities of small molecules like remdesivir, the combination of lopinavir/ritonavir, hydroxychloroquine, and chloroquine. Results recently published on the clinical evaluation of those drugs are compiled in this brief report, although complete data are still impatiently awaited. url: https://www.ncbi.nlm.nih.gov/pubmed/32423027/ doi: 10.3390/ph13050098 id: cord-323705-n2rec4i8 author: Varatharaj, Aravinthan title: Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Concerns regarding potential neurological complications of COVID-19 are being increasingly reported, primarily in small series. Larger studies have been limited by both geography and specialty. Comprehensive characterisation of clinical syndromes is crucial to allow rational selection and evaluation of potential therapies. The aim of this study was to investigate the breadth of complications of COVID-19 across the UK that affected the brain. METHODS: During the exponential phase of the pandemic, we developed an online network of secure rapid-response case report notification portals across the spectrum of major UK neuroscience bodies, comprising the Association of British Neurologists (ABN), the British Association of Stroke Physicians (BASP), and the Royal College of Psychiatrists (RCPsych), and representing neurology, stroke, psychiatry, and intensive care. Broad clinical syndromes associated with COVID-19 were classified as a cerebrovascular event (defined as an acute ischaemic, haemorrhagic, or thrombotic vascular event involving the brain parenchyma or subarachnoid space), altered mental status (defined as an acute alteration in personality, behaviour, cognition, or consciousness), peripheral neurology (defined as involving nerve roots, peripheral nerves, neuromuscular junction, or muscle), or other (with free text boxes for those not meeting these syndromic presentations). Physicians were encouraged to report cases prospectively and we permitted recent cases to be notified retrospectively when assigned a confirmed date of admission or initial clinical assessment, allowing identification of cases that occurred before notification portals were available. Data collected were compared with the geographical, demographic, and temporal presentation of overall cases of COVID-19 as reported by UK Government public health bodies. FINDINGS: The ABN portal was launched on April 2, 2020, the BASP portal on April 3, 2020, and the RCPsych portal on April 21, 2020. Data lock for this report was on April 26, 2020. During this period, the platforms received notification of 153 unique cases that met the clinical case definitions by clinicians in the UK, with an exponential growth in reported cases that was similar to overall COVID-19 data from UK Government public health bodies. Median patient age was 71 years (range 23–94; IQR 58–79). Complete clinical datasets were available for 125 (82%) of 153 patients. 77 (62%) of 125 patients presented with a cerebrovascular event, of whom 57 (74%) had an ischaemic stroke, nine (12%) an intracerebral haemorrhage, and one (1%) CNS vasculitis. 39 (31%) of 125 patients presented with altered mental status, comprising nine (23%) patients with unspecified encephalopathy and seven (18%) patients with encephalitis. The remaining 23 (59%) patients with altered mental status fulfilled the clinical case definitions for psychiatric diagnoses as classified by the notifying psychiatrist or neuropsychiatrist, and 21 (92%) of these were new diagnoses. Ten (43%) of 23 patients with neuropsychiatric disorders had new-onset psychosis, six (26%) had a neurocognitive (dementia-like) syndrome, and four (17%) had an affective disorder. 18 (49%) of 37 patients with altered mental status were younger than 60 years and 19 (51%) were older than 60 years, whereas 13 (18%) of 74 patients with cerebrovascular events were younger than 60 years versus 61 (82%) patients older than 60 years. INTERPRETATION: To our knowledge, this is the first nationwide, cross-specialty surveillance study of acute neurological and psychiatric complications of COVID-19. Altered mental status was the second most common presentation, comprising encephalopathy or encephalitis and primary psychiatric diagnoses, often occurring in younger patients. This study provides valuable and timely data that are urgently needed by clinicians, researchers, and funders to inform immediate steps in COVID-19 neuroscience research and health policy. FUNDING: None. url: https://api.elsevier.com/content/article/pii/S221503662030287X doi: 10.1016/s2215-0366(20)30287-x id: cord-274802-7ioiwsd8 author: Varghese, Praveen Mathews title: Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies date: 2020-08-19 words: 19657.0 sentences: 1033.0 pages: flesch: 42.0 cache: ./cache/cord-274802-7ioiwsd8.txt txt: ./txt/cord-274802-7ioiwsd8.txt summary: Proteomic and transcriptomic studies on bronchoalveolar lavage (BAL) samples from COVID-19 patients have also revealed considerable insights into the expression of SARS-CoV-2 receptors, co-receptors, immune responses, as well as risk factors for severe disease e.g. age and co-morbidities. Furthermore, treatment with a recombinant C5a antibody on 2 male COVID-19 patients aged 54 and 67 years showed significant benefit in suppressing complement hyperactivation, which contributes to the excessive immune response causing aggravated inflammatory lung injury, a hallmark of SARS-CoV-2 pathogenesis and lethality (242) . Consistent with endothelial injury, the significantly elevated levels of von Willebrand factor found in the patient with severe COVID-19 has led to the idea that the infection of the ACE2 expressing endothelium by SARS-CoV-2 induces injury and activates the complement , which sets up a feedback loop that maintains a state of inflammation (243, (268) (269) (270) . Initial clinical studies in China involving 100 SARS-CoV-2 infected patients, who were treated with Chloroquine, showed amelioration of pneumonia, shortened disease progression, increased resolution of lung lesions on CT, and a better virus-negative conversion (313, 314) . abstract: Abstract The current coronavirus pandemic, COVID-19, is the third outbreak of disease caused by the coronavirus family, after Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome. It is an acute infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 Virus (SARS-CoV-2). The severe disease is characterised by acute respiratory distress syndrome, septic shock, metabolic acidosis, coagulation dysfunction, and multiple organ dysfunction syndromes. Currently, no drugs or vaccine exist against the disease and the only course of treatment is symptom management involving mechanical ventilation, immune suppressants, and repurposed drugs. As such the severe form of the disease has a relatively high mortality rate. Last 6 months have seen an explosion of information related to the host receptors, virus transmission, virus structure-function relationships, pathophysiology, co-morbidities, immune response, treatment and most promising vaccines. This review takes a critically comprehensive look at various aspects of host-pathogen interaction in COVID-19. We examine genomic aspects of SARS-CoV-2, modulation of innate and adaptive immunity, complement-triggered microangiopathy, and host transmission modalities. We also examine its pathophysiological impact during pregnancy, in addition to various gaps in our knowledge. The lessons learnt from various clinical trials involving repurposed drugs have been summarised. We also highlight the rationale and likely success of the most promising vaccine candidates. url: https://www.ncbi.nlm.nih.gov/pubmed/33130519/ doi: 10.1016/j.imbio.2020.152008 id: cord-011725-t1jl4cy1 author: Varma, Niraj title: HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date: 2020-06-11 words: 3643.0 sentences: 193.0 pages: flesch: 38.0 cache: ./cache/cord-011725-t1jl4cy1.txt txt: ./txt/cord-011725-t1jl4cy1.txt summary: In light of the current pandemic, monitoring strategies should focus on selecting high-risk patients in need of close surveillance and using alternative remote recording devices to preserve personal protective equipment and protect health care workers from potential contagious harm. 21-23 Virtual clinics move far beyond simple telephone contacts by integrating information from photos, video, mobile heart rhythm and mobile health devices recording ECG, and remote cardiovascular implantable electronic device (CIED) interrogations. In the outpatient setting, a recent statement from the US Food & Drug Administration (FDA) "cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems." (This does not affect FDA-approved uses for malaria, lupus, and rheumatoid arthritis.) 51 Exceptions to this practice are acknowledged to occur in some regions, as these drugs have been used outside the United States without regulatory warnings. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313983/ doi: 10.1093/europace/euaa187 id: cord-312798-2cbgnv1h author: Varma, Niraj title: HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32534936/ doi: 10.1016/j.jacc.2020.06.019 id: cord-034578-i9rdubix author: Vaschetto, Rosanna title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 words: 3678.0 sentences: 206.0 pages: flesch: 46.0 cache: ./cache/cord-034578-i9rdubix.txt txt: ./txt/cord-034578-i9rdubix.txt summary: AIM: We aim at characterising a large population of Coronavirus 19 (COVID-19) patients with moderate-to-severe hypoxemic acute respiratory failure (ARF) receiving CPAP outside intensive care unit (ICU), and ascertaining whether the duration of CPAP application increased the risk of mortality for patients requiring intubation. We designed this retrospective multicentre study to describe the clinical characteristics of patients with laboratory-confirmed COVID-19 treated with CPAP outside ICU, to assess 60-day in-hospital mortality, and hospital length of stay (LOS), and to ascertain whether the duration CPAP application prior to CPAP failure affects outcome in patients requiring endotracheal intubation. This multicentre retrospective observational study on 537 patients hypoxemic ARF secondary to laboratory-confirmed COVID-19 infection, shows that CPAP applied to different therapeutic goals i.e., candidate to intubation in the case of CPAP failure and do-not-intubate in which CPAP is considered the ceiling of treatment, is feasible outside ICU. abstract: AIM: We aim at characterising a large population of Coronavirus 19 (COVID-19) patients with moderate-to-severe hypoxemic acute respiratory failure (ARF) receiving CPAP outside intensive care unit (ICU), and ascertaining whether the duration of CPAP application increased the risk of mortality for patients requiring intubation. METHODS: In this retrospective, multicentre cohort study, we included COVID-19 adult patients, treated with CPAP outside ICU for hypoxemic ARF from March 1(st) to April 15(th), 2020. We collected demographic and clinical data, including CPAP therapeutic goal, hospital length of stay (LOS), and 60-day in-hospital mortality. RESULTS: The study includes 537 patients with a median age of 69 (IQR, 60–76) years. Males were 391 (73%). According to predefined CPAP therapeutic goal, 397 (74%) patients were included in full treatment subgroup, and 140 (26%) in the do-not intubate (DNI) subgroup. Median CPAP duration was 4 (IQR, 1–8) days, while hospital LOS 16 (IQR, 9–27) days. Sixty-day in-hospital mortality was overall 34% (95%CI, 0.304–0.384), and 21% (95%CI, 0.169–0.249) and 73% (95%CI, 0.648–0.787) for full treatment and DNI subgroups, respectively. In the full treatment subgroup, in-hospital mortality was 42% (95%CI, 0.345–0.488) for 180 (45%) CPAP failures requiring intubation, while 2% (95%CI, 0.008–0.035) for the remaining 217 (55%) patients who succeeded. Delaying intubation was associated with increased mortality [HR, 1.093 (95%CI, 1.010–1.184)]. CONCLUSIONS: We described a large population of COVID-19 patients treated with CPAP outside ICU. Intubation delay represents a risk factor for mortality. Further investigation is needed for early identification of CPAP failures. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607967/ doi: 10.1183/23120541.00541-2020 id: cord-287508-133inel2 author: Vasudevan, Rajiv S. title: Persistent Value of the Stethoscope in the Age of COVID-19 date: 2020-06-19 words: 3738.0 sentences: 189.0 pages: flesch: 39.0 cache: ./cache/cord-287508-133inel2.txt txt: ./txt/cord-287508-133inel2.txt summary: • Stethoscopes are clinically valuable and integral to the doctor-patient connection; • Technological advancement will augment the utility of the stethoscope; • The stethoscope has high utility for assessment of COVID-19 patients; • Pathogen contamination in light of COVID-19 is a concern for the stethoscope; • Innovations in stethoscope hygiene will allow safe auscultation. During times of increased concern about contamination and spread of infections, physicians may opt to forgo their stethoscopes due to a lack of clear guidance on cleaning, lack of access to proper hygiene materials, or inconvenience with current personal protective equipment guidelines. Rather than forgoing a tool that might be useful in the prognostication of infected patients with cardiopulmonary abnormalities, it is important that novel hygienic and technological interventions be investigated to allow safe usage of the stethoscope. Advances in stethoscope technology will improve the auscultatory capabilities of health care workers and allow less contact with patients in transmission-based precautions. abstract: The stethoscope has long been at the center of patient care as well as a symbol of the physician-patient relationship. While advancements in other diagnostic modalities have allowed for more efficient and accurate diagnosis, the stethoscope has evolved in parallel to address the needs of the modern era of medicine. These advancements include sound visualization, ambient noise reduction/cancellation, Bluetooth™ transmission, and computer algorithm diagnostic support. However, despite these advancements, the ever-changing climate of infection prevention, especially in the wake of the COVID-19 pandemic, has led many to question the stethoscope as a vector for infectious diseases. Stethoscopes have been reported to harbor bacteria with contamination levels comparable to a physician's hand. Although disinfection is recommended, stethoscope hygiene compliance remains low. In addition, disinfectants may not be completely effective in eliminating microorganisms. Despite these risks, the growing technological integration with the stethoscope continues to make it a highly valuable tool. Rather than casting our valuable tool and symbol of medicine aside, we must create and implement an effective method of stethoscope hygiene to keep patients safe. • Stethoscopes are clinically valuable and integral to the doctor-patient connection; • Technological advancement will augment the utility of the stethoscope; • The stethoscope has high utility for assessment of COVID-19 patients; • Pathogen contamination in light of COVID-19 is a concern for the stethoscope; • Innovations in stethoscope hygiene will allow safe auscultation. url: https://www.sciencedirect.com/science/article/pii/S0002934320305088?v=s5 doi: 10.1016/j.amjmed.2020.05.018 id: cord-012037-9kmul7he author: Veenis, J. F. title: Remote monitoring of chronic heart failure patients: invasive versus non-invasive tools for optimising patient management date: 2019-11-19 words: 4452.0 sentences: 208.0 pages: flesch: 39.0 cache: ./cache/cord-012037-9kmul7he.txt txt: ./txt/cord-012037-9kmul7he.txt summary: Recently, the CardioMEMS device (Abbott Inc., Atlanta, GA, USA), an implantable haemodynamic remote monitoring sensor, has shown promising results in preventing HF-related hospitalisations in chronic HF patients hospitalised in the previous year and in New York Heart Association functional class III in the United States. Multiple studies have investigated the remote monitoring abilities of implantable cardioverter defibrillator/cardiac resynchronisation therapy (ICD/CRT) devices in chronic HF patients to improve HF-related hospitalisation rates (Tab. 2). The IN-TIME RCT showed that using the remote monitoring abilities of the ICD and CRT devices leads to a reduction of a combined endpoint of all-cause death, overnight HF-related hospitalisation, change in New York Heart Association (NYHA) class, and change in patient global self-assessment [19] . In this trial, NYHA class III/IV chronic HF patients were included and investigated as to whether remote haemodynamic monitoring using the ePAD could reduce HF-related hospitalisation, emergency or urgent care visits requiring intravenous therapy. abstract: Exacerbations of chronic heart failure (HF) with the necessity for hospitalisation impact hospital resources significantly. Despite all of the achievements in medical management and non-pharmacological therapy that improve the outcome in HF, new strategies are needed to prevent HF-related hospitalisations by keeping stable HF patients out of the hospital and focusing resources on unstable HF patients. Remote monitoring of these patients could provide the physicians with an additional tool to intervene adequately and promptly. Results of telemonitoring to date are inconsistent, especially those of telemonitoring with traditional non-haemodynamic parameters. Recently, the CardioMEMS device (Abbott Inc., Atlanta, GA, USA), an implantable haemodynamic remote monitoring sensor, has shown promising results in preventing HF-related hospitalisations in chronic HF patients hospitalised in the previous year and in New York Heart Association functional class III in the United States. This review provides an overview of the available evidence on remote monitoring in chronic HF patients and future perspectives for the efficacy and cost-effectiveness of these strategies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940410/ doi: 10.1007/s12471-019-01342-8 id: cord-346721-l6y3n21b author: Vega, Marisa title: From the Trenches: Inpatient Management of COVID-19 in Pregnancy date: 2020-06-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: ABSTRACT The novel coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 has become a pandemic. It has quickly swept across the globe leaving many clinicians to care for infected patients with limited information about the disease and best practices for care. Our goal is to share our experiences of caring for pregnant and postpartum women with novel coronavirus disease 2019 (COVID-19) in New York, the COVID-19 epicenter in the United States and review current guidelines. We offer a guide, focusing on inpatient management, including testing policies, admission criteria, medical management, care for the decompensating patient, as well as practical tips for inpatient antepartum service management. url: https://www.sciencedirect.com/science/article/pii/S2589933320300987?v=s5 doi: 10.1016/j.ajogmf.2020.100154 id: cord-028260-mja2jrgm author: Velasco Puyó, Pablo title: Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome() date: 2020-07-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328534/ doi: 10.1016/j.anpede.2020.05.002 id: cord-014533-6qfecv5h author: Velasquez, T. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 words: 88380.0 sentences: 5139.0 pages: flesch: 52.0 cache: ./cache/cord-014533-6qfecv5h.txt txt: ./txt/cord-014533-6qfecv5h.txt summary: P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. Methods: This descriptive observational study was conducted on consecutive 100 pediatric surgical patients who admitted to PSICUs at Cairo University Hospitals starting from 1/6-1/12/2015.After approval by research ethics committee,informed consents were obtained from parents and pediatric cases aged from 1 month-18 years and stayed for > 48 h were enrolled.MPV and PLC were obtained and recorded at baseline(preoperative values),on the day of ICU admission(day 0),1 st ,2 nd ,3 rd ,5 th and 7 th days.To measure daily MPV changes; (ΔMPV) was constructed and computed where ΔMPV = ([MPVday(X) − MPVday (0)]/MPVday(0) × 100 %. Results: The results obtained after analyzing the two homogeneous groups according to age, gender, type of admission and severity influencing the physiotherapy care in ICU quality indicators, in the Sagrada Esperança clinic, highlights the decrease of the average number of days with mechanical ventilation but it is not observed a significant relation between physical therapy and this indicator (p = 0:06). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042925/ doi: 10.1186/s40635-016-0100-7 id: cord-263793-bmadusm6 author: Velissaris, Dimitrios title: Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group date: 2020-05-12 words: 3753.0 sentences: 227.0 pages: flesch: 55.0 cache: ./cache/cord-263793-bmadusm6.txt txt: ./txt/cord-263793-bmadusm6.txt summary: In light of the accumulating evidence on the negative predictive value of soluble urokinase plasminogen activator receptor (suPAR), a group of experts from the fields of intensive care medicine, emergency medicine, internal medicine and infectious diseases frame a position statement on the role of suPAR in the screening of patients admitted to the emergency department. The main content of this statement is that sUPAR is a non-specific marker associated with a high negative predictive value for unfavourable outcomes; levels < 4 ng/ml indicate that it is safe to discharge the patient, whereas levels > 6 ng/ml are an alarming sign of risk for unfavourable outcomes. Since the group has shown long-term expertise in the clinical value of suPAR (soluble urokinase plasminogen activator receptor), we decided to frame a position paper on the role of suPAR in the early detection of risk of unfavourable outcome for patients admitted to the ED. abstract: In light of the accumulating evidence on the negative predictive value of soluble urokinase plasminogen activator receptor (suPAR), a group of experts from the fields of intensive care medicine, emergency medicine, internal medicine and infectious diseases frame a position statement on the role of suPAR in the screening of patients admitted to the emergency department. The statement is framed taking into consideration existing publications and our own research experience. The main content of this statement is that sUPAR is a non-specific marker associated with a high negative predictive value for unfavourable outcomes; levels < 4 ng/ml indicate that it is safe to discharge the patient, whereas levels > 6 ng/ml are an alarming sign of risk for unfavourable outcomes. However, the suPAR levels should always be interpreted in light of the patient's history. url: https://doi.org/10.1007/s40121-020-00301-w doi: 10.1007/s40121-020-00301-w id: cord-303054-s1clwunc author: Velly, Lionel title: Guidelines: Anaesthesia in the context of COVID-19 pandemic date: 2020-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: ABSTRACT Objectives: The world is currently facing an unprecedented healthcare crisis caused by COVID-19 pandemic. The objective of these guidelines is to produce a framework to facilitate the partial and gradual resumption of intervention activity in the context of the COVID-19 pandemic. Methods: The group has endeavoured to produce a minimum number of recommendations to highlight the strengths to be retained in the 7 predefined areas: (1) Protection of staff and patients; (2) Benefit/Risk and Patient Information; (3) Pre-operative assessment and decision on intervention; (4) Modalities of the pre-anaesthesia consultation; (5) Specificity of anaesthesia and analgesia; (6) Dedicated circuits and (7) Containment Exit Type of Interventions. Results: The SFAR Guideline panel provides 51 statements on anaesthesia management in the context of COVID-19 pandemic. After one round of discussion and various amendments, a strong agreement was reached for 100% of the recommendations and algorithms. Conclusion: We present suggestions for how the risk of transmission by and to anaesthetists can be minimised and how personal protective equipment policies relate to COVID-19 pandemic context url: https://doi.org/10.1016/j.accpm.2020.05.012 doi: 10.1016/j.accpm.2020.05.012 id: cord-017350-rwqaw5ii author: Venet, F. title: Monitoring Immune Dysfunction in Septic Patients: Toward Tailored Immunotherapy date: 2010-03-10 words: 3966.0 sentences: 182.0 pages: flesch: 36.0 cache: ./cache/cord-017350-rwqaw5ii.txt txt: ./txt/cord-017350-rwqaw5ii.txt summary: This review will focus on the immune dysfunctions described so far in septic patients regarding monocytes and T lymphocytes (as examples of innate and adaptive immune cells) and their potential use as biomarkers on a routine standardized basis for prediction of adverse outcome or occurrence of secondary nosocomial infections and for guidance of putative immunotherapy. With that said, the down modulation of CD14 expression on monocytes after septic shock (a cell surface marker decreased during monocyte apoptosis) tends to confirm this increased apoptotic process especially because its downregulation was more pronounced in patients who were not going to survive [12] . A growing body of evidence has now confirmed that the lymphocyte-mediated immune response may be dysfunctional after severe sepsis and may play a major role in the development of a state of immunosuppression in such patients [1, 18] . abstract: Septic syndromes represent a major although largely under-recognized healthcare problem worldwide accounting for thousands of deaths every year [1–3]. Mortality remains high ranging from 20 % for sepsis to over 50 % for septic shock despite almost 20 years of anti-inflammatory clinical trials [1–3]. The inability of these therapies to mitigate the devastating effects of this condition indicates that the initial hypotheses for sepsis pathophysiology may have been misconstrued or inadequately addressed. Two major explanations have been proposed: 1) Septic patients have mainly been treated as a group despite the extreme heterogeneity characterizing this population [1]; 2) The postulate that death after sepsis is solely due to an overwhelming pro-inflammatory immune response may actually be inaccurate [1, 3]. Indeed, several lines of evidence have now established that death from septic shock is probably due to the effect of distinct mechanisms over time [1–3]. Early in the course of the disease, a massive release of inflammatory mediators (normally designed to trigger an immune response against pathogens) is occurring that may be responsible for organ dysfunction and hypoperfusion [1, 3]. Concomitantly, the body develops compensatory mechanisms to prevent overwhelming inflammation and dampen an overzealous anti-infectious response [1–3]. These negative feedback mechanisms, although having protective effects during the first initial hours, may paradoxically become deleterious as they persist over time leading to immune paralysis (Fig. 1) [1, 3]. Indeed, considerable clinical and experimental evidence indicates that patients rapidly present with numerous compromised immune functions [1, 3]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121891/ doi: 10.1007/978-0-387-92278-2_8 id: cord-300080-l0fyxtva author: Venkat, Arvind title: Ethical Issues in the Response to Ebola Virus Disease in US Emergency Departments: A Position Paper of the American College of Emergency Physicians, the Emergency Nurses Association and the Society for Academic Emergency Medicine date: 2015-03-10 words: 8369.0 sentences: 336.0 pages: flesch: 43.0 cache: ./cache/cord-300080-l0fyxtva.txt txt: ./txt/cord-300080-l0fyxtva.txt summary: With the presentation of patients with Ebola to US acute care facilities, ethical questions have been raised in both the press and medical literature as to how US emergency departments, emergency physicians, emergency nurses and other stakeholders in the healthcare system should approach the current epidemic and its potential for spread in the domestic environment. With the presentation of patients with Ebola to US acute care facilities, ethical questions have been raised in both the press and medical literature as to how US emergency departments, emergency physicians, emergency nurses and other stakeholders in the healthcare system should approach the current epidemic and its potential for spread in the domestic environment. WHAT 41 It is anticipated that patients with a confirmed EVD diagnosis will be transferred to these hospitals which will have enough PPE and other treatment requirements (isolation rooms, dedicated equipment and designated physicians, nurses and other necessary health care professionals and staff with proper training under CDC guidelines) to manage patients for at least 7 days, after which governmental agencies would assist in acquiring more supplies and expertise if needed. abstract: The 2014 outbreak of Ebola Virus Disease (EVD) in West Africa has presented a significant public health crisis to the international health community and challenged US emergency departments to prepare for patients with a disease of exceeding rarity in developed nations. With the presentation of patients with Ebola to US acute care facilities, ethical questions have been raised in both the press and medical literature as to how US emergency departments, emergency physicians, emergency nurses and other stakeholders in the healthcare system should approach the current epidemic and its potential for spread in the domestic environment. To address these concerns, the American College of Emergency Physicians, the Emergency Nurses Association and the Society for Academic Emergency Medicine developed this joint position paper to provide guidance to US emergency physicians, emergency nurses and other stakeholders in the healthcare system on how to approach the ethical dilemmas posed by the outbreak of EVD. This paper will address areas of immediate and potential ethical concern to US emergency departments in how they approach preparation for and management of potential patients with EVD. url: https://www.ncbi.nlm.nih.gov/pubmed/25770003/ doi: 10.1016/j.jen.2015.01.012 id: cord-002514-pp06m5xk author: Venkatesan, Sudhir title: Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis date: 2017-05-15 words: 4019.0 sentences: 173.0 pages: flesch: 40.0 cache: ./cache/cord-002514-pp06m5xk.txt txt: ./txt/cord-002514-pp06m5xk.txt summary: title: Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis While evidence exists to support the effectiveness of neuraminidase inhibitors (NAIs) in reducing mortality when given to hospitalized patients with A(H1N1)pdm09 virus infection, the impact of outpatient treatment on hospitalization has not been clearly established. In patients with laboratory-confirmed or clinically diagnosed A(H1N1)pdm09 influenza, after adjustment for community-based antibiotic treatment and propensity score, the likelihood of hospital admission in patients with outpatient or community-based NAI treatment was 0.24 (95% CI, 0.20-0.30) when compared to no NAI treatment in the community (Table 2) . Our main findings ( Table 2) suggest that NAI treatment in the community for patients with severe pandemic influenza substantially reduced the likelihood of hospital admission due to influenza A(H1N1)pdm09. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data abstract: BACKGROUND. While evidence exists to support the effectiveness of neuraminidase inhibitors (NAIs) in reducing mortality when given to hospitalized patients with A(H1N1)pdm09 virus infection, the impact of outpatient treatment on hospitalization has not been clearly established. We investigated the impact of outpatient NAI treatment on subsequent hospitalization in patients with A(H1N1)pdm09 virus infection. METHODS. We assembled general community and outpatient data from 9 clinical centers in different countries collected between January 2009 and December 2010. We standardized data from each study center to create a pooled dataset and then used mixed-effects logistic regression modeling to determine the effect of NAI treatment on hospitalization. We adjusted for NAI treatment propensity and preadmission antibiotic use, including “study center” as a random intercept to account for differences in baseline hospitalization rate between centers. RESULTS. We included 3376 patients with influenza A(H1N1)pdm09, of whom 3085 (91.4%) had laboratory-confirmed infection. Eight hundred seventy-three patients (25.8%) received outpatient or community-based NAI treatment, 928 of 2395 (38.8%) with available data had dyspnea or respiratory distress, and hospitalizations occurred in 1705 (50.5%). After adjustment for preadmission antibiotics and NAI treatment propensity, preadmission NAI treatment was associated with decreased odds of hospital admission compared to no NAI treatment (adjusted odds ratio, 0.24; 95% confidence interval, 0.20–0.30). CONCLUSIONS. In a population with confirmed or suspected A(H1N1)pdm09 and at high risk of hospitalization, outpatient or community-based NAI treatment significantly reduced the likelihood of requiring hospital admission. These data suggest that community patients with severe influenza should receive NAI treatment. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411393/ doi: 10.1093/cid/cix127 id: cord-011712-fyrbe8tw author: Venkatesan, Sudhir title: Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection date: 2020-02-01 words: 4623.0 sentences: 200.0 pages: flesch: 40.0 cache: ./cache/cord-011712-fyrbe8tw.txt txt: ./txt/cord-011712-fyrbe8tw.txt summary: METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. CONCLUSIONS: When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment. We undertook a one-stage individual participant data (IPD) [16] meta-analysis to explore the association between NAI treatment of patients hospitalized with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) infection and the LoS during the 2009-2010 influenza pandemic. In Hong Kong, a study of 356 adult patients hospitalized with laboratory-confirmed seasonal influenza showed that early oseltamivir treatment was associated with a reduced LoS in both unadjusted and multivariable analyses [9] , compared with no or later treatment, with the median LoS decreasing from 6 to 4 days; this accords with our primary analysis. abstract: BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded. RESULTS: We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI, .78–.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS. CONCLUSIONS: When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313925/ doi: 10.1093/infdis/jiz152 id: cord-280821-kc0ut4oy author: Venturini, Elisabetta title: Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date: 2020-09-24 words: 5481.0 sentences: 315.0 pages: flesch: 45.0 cache: ./cache/cord-280821-kc0ut4oy.txt txt: ./txt/cord-280821-kc0ut4oy.txt summary: The Italian Society of Pediatric Infectious Diseases steering and scientific committee developed a position paper on treatment of children with COVID-19, reviewing the current literature on this topic and providing indications based on the available literature data. Currently, American guidelines on COVID-19 treatment published in May 2020, recommend both in children and adults to use lopinavir/ritonavir only in the context of clinical trials, given the lack of effectiveness reported now in literature [9, 12] . The latest Chinese guidelines on SARS-Cov-2 pneumoniae do not recommend the use of a specific antiviral for the treatment of COVID-19, and nevertheless include lopinavir/ritonavir among the available therapeutic options for hospitalized patients [29] . In May 2020, following an assessment of the emergency use authorization criteria and available scientific evidence, the FDA issued an emergency use authorization allowing for the administration of remdesivir intravenously by health care providers for the treatment of COVID-19 suspected or laboratoryconfirmed in adults and pediatric patients hospitalized with severe disease [34] . abstract: A statement of consensus was formulated after reviewing available literature on pediatric treatment strategies for COVID-19 by the Steering and Scientific Committee of the Italian Society of Infectious Pediatric Diseases in connection with the Italian Society of Paediatrics. url: https://doi.org/10.1186/s13052-020-00900-w doi: 10.1186/s13052-020-00900-w id: cord-338668-z2z4gte2 author: Veraldi, Stefano title: Seborrheic dermatitis and masks date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In Milan, Italy, after the end of the lockdown period (March and April 2020), we observed several patients with seborrheic dermatitis (SD) who showed a more or less important worsening of their disease. All patients used anti‐coronavirus‐19 (COVID‐19) face mask for many hours per day. According to the clinical point of view, the worsening was characterized by increased erythema and desquamation as well as itching worsened. In the last few weeks, some articles have been published on cases of dermatitis of the face associated with the use of anti‐COVID‐19 masks. Some authors hypothesized that this condition is due to high temperature of the face covered by the mask, that induces an increased sebum excretion rate. In our patients with SD, it is possible that high temperature of the face induces abnormalities of microbiota (proliferation of Malassezia spp.?) and permeability of skin barrier, and increases sweating with irritant action and worsening of itching. url: https://doi.org/10.1111/jocd.13669 doi: 10.1111/jocd.13669 id: cord-275004-qzg03dvg author: Veras, Flavio Protasio title: SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology date: 2020-09-14 words: 6380.0 sentences: 383.0 pages: flesch: 51.0 cache: ./cache/cord-275004-qzg03dvg.txt txt: ./txt/cord-275004-qzg03dvg.txt summary: The concentration of NETs was augmented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neutrophils released higher levels of NETs. Notably, we found that viable SARS-CoV-2 can directly induce the release of NETs by healthy neutrophils. The well-known similarities between sepsis and key events involved in the COVID-19 pathophysiology, such as cytokine overproduction (Mehta et al., 2020) , microthrombosis (Magro et al., 2020; Dolhnikoff et al., 2020) , and acute respiratory distress syndrome (Lai et al., 2020) , led us to hypothesize that NETs are triggered during SARS-CoV-2 infection and might contribute to tissue injury in COVID-19 patients. In summary, in the present study, we demonstrated that in COVID-19 patients, circulating and lung-infiltrating neutrophils are releasing higher levels of NETs. We also showed that SARS-CoV-2 directly stimulates neutrophils to release NETs in mechanisms dependent on ACE2 and serine protease activity axis and effective viral replication. abstract: Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved in COVID-19 pathophysiology. A cohort of 32 hospitalized patients with a confirmed diagnosis of COVID-19 and healthy controls were enrolled. The concentration of NETs was augmented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neutrophils released higher levels of NETs. Notably, we found that viable SARS-CoV-2 can directly induce the release of NETs by healthy neutrophils. Mechanistically, NETs triggered by SARS-CoV-2 depend on angiotensin-converting enzyme 2, serine protease, virus replication, and PAD-4. Finally, NETs released by SARS-CoV-2–activated neutrophils promote lung epithelial cell death in vitro. These results unravel a possible detrimental role of NETs in the pathophysiology of COVID-19. Therefore, the inhibition of NETs represents a potential therapeutic target for COVID-19. url: https://doi.org/10.1084/jem.20201129 doi: 10.1084/jem.20201129 id: cord-335033-cwhm7v0s author: Vergano, Marco title: Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic date: 2020-04-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1186/s13054-020-02891-w doi: 10.1186/s13054-020-02891-w id: cord-330492-kbob8z48 author: Vervoort, Dominique title: Assessing the Collateral Damage of the Novel Coronavirus: A Call to Action for the Post-COVID-19 Era date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0003497520306184?v=s5 doi: 10.1016/j.athoracsur.2020.04.015 id: cord-281752-64mrflcr author: Vespignani, Hervé title: Report of EEG Finding on Critically Ill Patients with COVID‐19 date: 2020-06-13 words: 2115.0 sentences: 116.0 pages: flesch: 49.0 cache: ./cache/cord-281752-64mrflcr.txt txt: ./txt/cord-281752-64mrflcr.txt summary: Of the 26 patients studied, 5 patients had EEGs that showed Periodic Discharges (PD) consisting of high amplitude frontal monomorphic delta waves with absence of epileptic activity. However, the presence of the monomorphic biphasic high amplitude delta waves associated with occasional myoclonic muscular activity could also possibly be indicative of brain injury either related to anoxia, severe hypoxia, anesthesia, or the direct effects of COVID-19 itself. The reported onset of loss of consciousness or confusion and cognitive impairment in COVID-19 infected patients with EEGs revealing biphasic delta PDs may suggest an injury or localized brain defect attributed to encephalopathy related to a unique and acute CNS process. When hospitalized patients infected with SARS-CoV-2 (COVID-19) present with an unexplained loss of consciousness, confusion or altered mental status, impaired arousal, and abnormal paroxysmal movements (myoclonus), it is suggested that an EEG be performed as part of the diagnostic assessment of the patient to determine an etiology and to identify potentially treatable CNS disorders. abstract: In March 2020, we treated a cohort of 26 critically ill hospitalized SARS‐CoV‐2 infected patients who received EEGs to assess unexplained altered mental status, loss of consciousness, or poor arousal and responsiveness. Of the 26 patients studied, 5 patients had EEGs that showed Periodic Discharges (PD) consisting of high amplitude frontal monomorphic delta waves with absence of epileptic activity. These findings may suggest CNS injury potentially related to COVID‐19 in these patients. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/ana.25814 doi: 10.1002/ana.25814 id: cord-260605-smkr7b15 author: Vestby, Lene K. title: Bacterial Biofilm and its Role in the Pathogenesis of Disease date: 2020-02-03 words: 12145.0 sentences: 672.0 pages: flesch: 40.0 cache: ./cache/cord-260605-smkr7b15.txt txt: ./txt/cord-260605-smkr7b15.txt summary: However, the biofilm lifestyle of microorganisms were of no interest to medical microbiologists until the early 1970s when Nils Høiby observed a link between the etiology of a persistent infection and aggregates of bacteria in cystic fibrosis patients [1] . This is consistent with the experiments showing that many bacteria causing acute gallbladder infections do not form biofilms on gallstones in the presence of bile [73, 80] . This is consistent with the experiments showing that many bacteria causing acute gallbladder infections do not form biofilms on gallstones in the presence of bile [73, 80] . Several studies have detected higher incidence of Escherichia coli in patients with IBD compared to healthy individuals [90] and although biofilms were not demonstrated in vivo, the isolates were isolated from biopsies after removal of the mucosal layer, indicating adherence to the colonic epithelium and the isolates displayed biofilm forming capacity in vitro [90] . abstract: Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm infections are typically chronic in nature, as biofilm-residing bacteria can be resilient to both the immune system, antibiotics, and other treatments. This is a comprehensive review describing biofilm diseases in the auditory, the cardiovascular, the digestive, the integumentary, the reproductive, the respiratory, and the urinary system. In most cases reviewed, the biofilms were identified through various imaging technics, in addition to other study approaches. The current knowledge on how biofilm may contribute to the pathogenesis of disease indicates a number of different mechanisms. This spans from biofilm being a mere reservoir of pathogenic bacteria, to playing a more active role, e.g., by contributing to inflammation. Observations also indicate that biofilm does not exclusively occur extracellularly, but may also be formed inside living cells. Furthermore, the presence of biofilm may contribute to development of cancer. In conclusion, this review shows that biofilm is part of many, probably most chronic infections. This is important knowledge for development of effective treatment strategies for such infections. url: https://www.ncbi.nlm.nih.gov/pubmed/32028684/ doi: 10.3390/antibiotics9020059 id: cord-309962-phwq8rsf author: Vetter, Monica Hagan title: Chemotherapy directly followed by PARP inhibition as an alternative to surgery in patients with BRCA- mutated ovarian cancer – a potential management strategy in the era of COVID-19 date: 2020-05-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S000293782030569X?v=s5 doi: 10.1016/j.ajog.2020.05.037 id: cord-281733-bsq0ewac author: Veyseh, Maedeh title: Left gonadal vein thrombosis in a patient with COVID-19-associated coagulopathy date: 2020-09-07 words: 2461.0 sentences: 169.0 pages: flesch: 45.0 cache: ./cache/cord-281733-bsq0ewac.txt txt: ./txt/cord-281733-bsq0ewac.txt summary: We report an unusual case of ovarian vein thrombosis and pulmonary embolism associated with COVID-19 presenting with abdominal pain. We report an unusual case of ovarian vein thrombosis and pulmonary embolism associated with COVID-19 presenting with abdominal pain. To our knowledge, this is the first reported case of COVID-19 with absent respiratory symptoms and presentation with venous thrombosis in an unusual location. To our knowledge, this is the first reported case of COVID-19 with absent respiratory symptoms and presentation with venous thrombosis in an unusual location. 8 9 Our patient was distinctive in terms of presentation as she lacked the common respiratory symptoms, rather acute venous thrombosis in an unusual location prompted the diagnosis of COVID-19. 1 24 In summary, we present an interesting case with an unusual presentation of COVID-19 who presented with abdominal pain and no significant respiratory symptoms and was diagnosed with thrombosis of the left ovarian vein. abstract: COVID-19 disease is a viral illness that predominantly causes pneumonia and severe acute respiratory distress syndrome. The endothelial injury and hypercoagulability secondary to the inflammatory response predisposes severely ill patients to venous thromboembolism. The exact mechanism of hypercoagulability is still under investigation, but it is known to be associated with poor prognosis. The most common thrombotic complication reported among these patients is pulmonary embolism. To our knowledge, gonadal vein thrombosis is an uncommon phenomenon that has not been reported in the setting of COVID-19-associated coagulopathy. We report an unusual case of ovarian vein thrombosis and pulmonary embolism associated with COVID-19 presenting with abdominal pain. To our knowledge, this is the first reported case of COVID-19 with absent respiratory symptoms and presentation with venous thrombosis in an unusual location. url: https://doi.org/10.1136/bcr-2020-236786 doi: 10.1136/bcr-2020-236786 id: cord-351457-fzj3ciif author: Vezzoli, Pamela title: Cutaneous lupus erythematosus patients in a high‐epidemic COVID‐19 area, Bergamo, Italy date: 2020-06-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32506525/ doi: 10.1111/dth.13776 id: cord-292856-7hjzzxtm author: Viasus, Diego title: Influenza A(H1N1)pdm09-related pneumonia and other complications date: 2012-10-31 words: 4215.0 sentences: 294.0 pages: flesch: 34.0 cache: ./cache/cord-292856-7hjzzxtm.txt txt: ./txt/cord-292856-7hjzzxtm.txt summary: The main complications reported in hospitalized adults with influenza A(H1N1)pdm09 were pneumonia (primary influenza pneumonia and concomitant/secondary bacterial pneumonia), exacerbations of chronic pulmonary diseases (mainly chronic obstructive pulmonary disease and asthma), the need for intensive unit care admission (including mechanical ventilation, acute respiratory distress syndrome and septic shock), nosocomial infections and acute cardiac events. The main complications reported in hospitalized adults with influenza A(H1N1)pdm09 were pneumonia (primary influenza pneumonia and concomitant/secondary bacterial pneumonia), exacerbations of chronic pulmonary diseases (mainly chronic obstructive pulmonary disease and asthma), the need for intensive unit care admission (including mechanical ventilation, acute respiratory distress syndrome and septic shock), nosocomial infections and acute cardiac events. 6, 34, 35 Chronic pulmonary diseases, mainly COPD and asthma, are frequent comorbidities reported in hospitalized patients with influenza A(H1N1)pdm09 virus infection. abstract: Abstract Influenza A(H1N1)pdm09 virus infection was associated with significant morbidity, mainly among children and young adults. The majority of patients had self-limited mild-to-moderate uncomplicated disease. However, some patients developed severe illness and some died. In addition to respiratory complications, several complications due to direct and indirect effects on other body systems were associated with influenza A(H1N1)pdm09 virus infection. The main complications reported in hospitalized adults with influenza A(H1N1)pdm09 were pneumonia (primary influenza pneumonia and concomitant/secondary bacterial pneumonia), exacerbations of chronic pulmonary diseases (mainly chronic obstructive pulmonary disease and asthma), the need for intensive unit care admission (including mechanical ventilation, acute respiratory distress syndrome and septic shock), nosocomial infections and acute cardiac events. In experimentally infected animals, the level of pulmonary replication of the influenza A(H1N1)pdm09 virus was higher than that of seasonal influenza viruses. Pathological studies in autopsy specimens indicated that the influenza A(H1N1)pdm09 virus mainly targeted the lower respiratory tract, resulting in diffuse alveolar damage (edema, hyaline membranes, inflammation, and fibrosis), manifested clinically by severe acute respiratory distress syndrome with refractory hypoxemia. Influenza A(H1N1)pdm09-related pneumonia and other complications were associated with increased morbidity and mortality among hospitalized patients. url: https://www.sciencedirect.com/science/article/pii/S0213005X12701040 doi: 10.1016/s0213-005x(12)70104-0 id: cord-003798-nki2sasr author: Vidaur, Loreto title: Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis date: 2019-07-24 words: 3501.0 sentences: 195.0 pages: flesch: 41.0 cache: ./cache/cord-003798-nki2sasr.txt txt: ./txt/cord-003798-nki2sasr.txt summary: BACKGROUND: Information on the clinical, epidemiological and molecular characterization of human metapneumovirus in critically ill adult patients with severe community-acquired pneumonia (CAP) and the role of biomarkers identifying bacterial coinfection is scarce. METHODS: This is a retrospective epidemiological study of adult patients with hMPV severe CAP admitted to ICU during a ten-year period with admission PSI score ≥ 3. The main objective of this study was to describe the clinical and epidemiological characteristics of adults with severe pneumonia caused by hMPV who required intensive care unit (ICU) admission, over a long period of time. Interestingly, three patients (10.7%) were young adult patients without comorbidities and without bacterial coinfection that developed ARDS pointing out a main role of hMPV in the etiology of severe respiratory infections requiring mechanical ventilation. Main characteristics of immunosuppressed adult patients admitted to the Intensive Care Unit due to a severe community-acquired pneumonia associated with human metapneumovirus infection (Guipuzcoa, Basque Country, Spain, 2007-2017). abstract: BACKGROUND: Information on the clinical, epidemiological and molecular characterization of human metapneumovirus in critically ill adult patients with severe community-acquired pneumonia (CAP) and the role of biomarkers identifying bacterial coinfection is scarce. METHODS: This is a retrospective epidemiological study of adult patients with hMPV severe CAP admitted to ICU during a ten-year period with admission PSI score ≥ 3. RESULTS: The 92.8% of the 28 patients with severe CAP due to human metapneumovirus were detected during the first half of the year. Median age was 62 years and 60.7% were male. The genotyping of isolated human metapneumovirus showed group B predominance (60.7%). All patients had acute respiratory failure. Median APACHE II and SOFA score were 13 and 6.55, respectively. The 25% were coinfected with Streptococcus pneumoniae. 60.7% of the patients had shock at admission and 50% underwent mechanical ventilation. Seven patients developed ARDS, three of them younger than 60 years and without comorbidities. Mortality in ICU was 14.3%. Among survivors, ICU and hospital stay were 6.5 and 14 days, respectively. Plasma levels of procalcitonin were higher in patients with bacterial coinfection (18.2 vs 0.54; p < 0.05). The levels of C-reactive protein, however, were similar. CONCLUSION: Human metapneumovirus was associated with severe CAP requiring ICU admission among elderly patients or patients with comorbidities, but also in healthy young subjects. These patients often underwent mechanical ventilation with elevated health resource consumption. While one out of four patients showed pneumococcal coinfection, plasma procalcitonin helped to implement antimicrobial stewardship. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13613-019-0559-y) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656825/ doi: 10.1186/s13613-019-0559-y id: cord-344117-lr6roxej author: Vieira, Ana Luisa Silveira title: Role of point-of-care ultrasound during the COVID-19 pandemic: our recommendations in the management of dialytic patients date: 2020-06-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID-19 is a viral disease due to the infection of the novel Corona virus SARS-CoV-2, that has rapidly spread in many countries until the World Health Organization declared the pandemic from March 11, 2020. Elderly patients and those affected by hypertension, diabetes mellitus, and chronic pulmonary and cardiovascular conditions are more susceptible to present more severe forms of COVID-19. These conditions are often represented in dialytic renal end-stage patients. Moreover, dialysis patients are more vulnerable to infection due to suppression of the immune system. Growing evidences, although still supported by few publications, are showing the potential utility of ultrasound in patients with COVID-19. In this review, we share our experience in using point-of-care ultrasound, particularly lung ultrasound, to indicate the probability of COVID-19 in patients with end-stage renal disease treated by hemodialysis. We also propose recommendations for the application of lung ultrasound, focused echocardiography and inferior vena cava ultrasound in the management of patients in hemodialysis. url: https://doi.org/10.1186/s13089-020-00177-4 doi: 10.1186/s13089-020-00177-4 id: cord-284983-xvtkso79 author: Vigiola Cruz, Mariana title: Safety and Efficacy of Bedside Peritoneal Dialysis Catheter Placement in the COVID-19 Era: Initial Experience at a New York City Hospital date: 2020-05-26 words: 3938.0 sentences: 187.0 pages: flesch: 39.0 cache: ./cache/cord-284983-xvtkso79.txt txt: ./txt/cord-284983-xvtkso79.txt summary: title: Safety and Efficacy of Bedside Peritoneal Dialysis Catheter Placement in the COVID-19 Era: Initial Experience at a New York City Hospital INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is common in critically ill patients with COVID-19. Unparalleled numbers of patients with AKI and shortage of dialysis machines and operative resources prompted consideration of expanded use of urgent-start peritoneal dialysis (PD) and evaluation of the safety and efficacy of bedside surgical placement of PD catheters. The catheter should be flushed with heparinized saline following each critical step of the procedure to ensure adequate Insertion of the catheters in surgical clinic for ambulatory patients with CKD mimics the ICU bedside technique, with slight modifications. In our limited series, bedside placement of peritoneal dialysis catheters in the early phases of the COVID-19 pandemic offered a safe and effective option for establishment of access for renal replacement therapy. abstract: INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is common in critically ill patients with COVID-19. Unparalleled numbers of patients with AKI and shortage of dialysis machines and operative resources prompted consideration of expanded use of urgent-start peritoneal dialysis (PD) and evaluation of the safety and efficacy of bedside surgical placement of PD catheters. STUDY DESIGN: Bedside, open PD catheter insertions were performed in early April 2020, at a large academic center in New York City. Patients with SARS-CoV-2 infection and AKI and ambulatory patients with chronic kidney disease and impending need for RRT were included. Detailed surgical technique is described. RESULTS: Fourteen catheters were placed at the bedside over 2 weeks, 11 in critically ill COVID-19 patients and three in ambulatory patients. Mean patient age was 61.9 years (43–83), and mean body mass index was 27.1 (20–37.6); four patients had prior abdominal surgery. All catheters were placed successfully without routine radiographic studies or intraoperative complications. One patient (7%) experienced primary nonfunction of the catheter requiring HD. One patient had limited intraperitoneal bleeding while anticoagulated, which was managed by mechanical compression of the abdominal wall and temporarily holding anticoagulation. All other catheters had an adequate function at 3–18 days of follow-up. CONCLUSIONS: Bedside placement of PD catheters is safe and effective in ICU and outpatient clinic settings. Our surgical protocols allowed for optimization of critical hospital resources, minimization of hazardous exposure to healthcare providers and a broader application of urgent-start PD in selected patients. Long-term follow-up is warranted. url: https://doi.org/10.1007/s00268-020-05600-4 doi: 10.1007/s00268-020-05600-4 id: cord-019063-mcxbl8mv author: Vijayan, Vannan K. title: Diagnosis of Pulmonary Parasitic Diseases date: 2013-06-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The protozoal and helminthic parasites that traverse the respiratory tract during their life cycles can cause lung diseases, though the most common habitats of these parasites are the gastrointestinal tract and the blood or lymphatic circulations. These diseases are commonly encountered in the tropical regions of the world. However, parasitic lung diseases are increasingly being reported from other parts of the world due to an increase in the occurrence of immunosuppression (acquired immunodeficiency syndrome, organ transplantations, the use of immunosuppressive drugs) and transcontinental travel. The lung diseases that may result from these infections range from asymptomatic phase to life-threatening acute respiratory distress syndrome. These diseases can also mimic common respiratory diseases such as bacterial pneumonias, pulmonary tuberculosis, lung cancer, bronchial asthma, interstitial lung disease, and pulmonary hypertension. The diagnosis of parasitic lung diseases is a challenge to physicians, if they are not aware of the entity or these diseases are not investigated properly. The diagnosis of these diseases is based on the identification of the causative organism in the stool, sputum, other body fluids, or tissue specimens. Radiological imaging studies of the thorax including chest radiographs, high-resolution computerized tomograms, and ultrasonograms may aid in the diagnosis. In certain situations, invasive investigations such as fiberoptic bronchoscopic evaluation (transbronchial lung biopsies and bronchoalveolar lavage studies) and thoracic surgical procedures (thoracoscopy and open lung biopsy) may be required for a diagnosis and also to exclude other lung diseases. Serologic and molecular diagnostic methods are being developed for accurate diagnosis of the parasitic diseases. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124114/ doi: 10.1007/978-3-642-37609-2_1 id: cord-324232-nupi7f72 author: Villar, Jesús title: Rationale for Prolonged Corticosteroid Treatment in the Acute Respiratory Distress Syndrome Caused by Coronavirus Disease 2019 date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1097/cce.0000000000000111 doi: 10.1097/cce.0000000000000111 id: cord-252890-of29g89s author: Villarreal-Fernandez, Eduardo title: A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure date: 2020-06-12 words: 1019.0 sentences: 57.0 pages: flesch: 48.0 cache: ./cache/cord-252890-of29g89s.txt txt: ./txt/cord-252890-of29g89s.txt summary: A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure Eduardo Villarreal-Fernandez 1 , Ravi Patel 1 , Reshma Golamari 2 , Muhammad Khalid 2 , Ami DeWaters 2 and Philippe Haouzi 1* Indeed, since a profound hypoxemia appears to be the hallmark of COVID-19-associated pneumonia, the initial consensus [2] was to start invasive mechanical ventilation as soon as possible due to the overwhelming number of patients in respiratory failure presenting at the same time in a hospital and to prevent the risk of hypoxic cardiac arrest; (2) avoidance of high-flow nasal cannula (HFNC) to reduce respiratory droplet aerosolization for healthcare workers [3] in what was seen as "inevitable" intubations. After an initial increase in oxygen requirement through day 6, patients in this group were all able to be discharged at a time when most of the early-intubated patients were still mechanically ventilated (Fig. 1) . abstract: nan url: https://doi.org/10.1186/s13054-020-03063-6 doi: 10.1186/s13054-020-03063-6 id: cord-000522-d498qj2b author: Vincent, Jean-Louis title: Reducing mortality in sepsis: new directions date: 2002-12-05 words: 8709.0 sentences: 431.0 pages: flesch: 48.0 cache: ./cache/cord-000522-d498qj2b.txt txt: ./txt/cord-000522-d498qj2b.txt summary: Five topics were selected that have been shown in randomized, controlled trials to reduce mortality: limiting the tidal volume in acute lung injury or acute respiratory distress syndrome, early goal-directed therapy, use of drotrecogin alfa (activated), use of moderate doses of steroids, and tight control of blood sugar. The present article provides guidelines from experts in the field on optimal patient selection and timing for each intervention, and provides advice on how to integrate new therapies into ICU practice, including protocol development, so that mortality rates from this disease process can be reduced. The interventions discussed encompassed low tidal volume in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) (Edward Abraham), early goal-directed therapy (EGDT) (Emanuel Rivers), drotrecogin alfa (activated) (Gordon Bernard), moderate-dose corticosteroids (Djillali Annane), and tight control of blood sugar (Greet Van den Berghe). abstract: Considerable progress has been made in the past few years in the development of therapeutic interventions that can reduce mortality in sepsis. However, encouraging physicians to put the results of new studies into practice is not always simple. A roundtable was thus convened to provide guidance for clinicians on the integration and implementation of new interventions into the intensive care unit (ICU). Five topics were selected that have been shown in randomized, controlled trials to reduce mortality: limiting the tidal volume in acute lung injury or acute respiratory distress syndrome, early goal-directed therapy, use of drotrecogin alfa (activated), use of moderate doses of steroids, and tight control of blood sugar. One of the principal investigators for each study was invited to participate in the roundtable. The discussions and questions that followed the presentation of data by each panel member enabled a consensus recommendation to be derived regarding when each intervention should be used. Each new intervention has a place in the management of patients with sepsis. Furthermore, and importantly, the therapies are not mutually exclusive; many patients will need a combination of several approaches – an 'ICU package'. The present article provides guidelines from experts in the field on optimal patient selection and timing for each intervention, and provides advice on how to integrate new therapies into ICU practice, including protocol development, so that mortality rates from this disease process can be reduced. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239386/ doi: 10.1186/cc1860 id: cord-017337-vq3edhxn author: Vincent, Jean-Louis title: PIRO: The Key to Success? date: 2009 words: 3809.0 sentences: 176.0 pages: flesch: 47.0 cache: ./cache/cord-017337-vq3edhxn.txt txt: ./txt/cord-017337-vq3edhxn.txt summary: Building on a system that had emerged at the Fifth Toronto Sepsis Roundtable held in Toronto, Canada, in 2000 [6] , the sepsis defi nitions conference participants, therefore, proposed the PIRO system [5] , which can classify patients on the basis of their predisposing conditions, the nature and extent of the infection, the nature and magnitude of the host response, and the degree of concomitant organ dysfunction. The PIRO system for the grading of sepsis uses clinical and laboratory parameters to aid diagnosis and patient classifi cation, with each element being divided according to the degree of involvement (e.g., infection can be classifi ed as localized, extended, or generalized; immune response can be classifi ed as limited, extensive, or excessive; organ dysfunction can be classifi ed as mild, moderate, severe). Improved classifi cation of septic patients using the PIRO system may, thus, facilitate the development and evaluation of clinical trials of sepsis therapies and will also encourage further study into the pathophysiology and epidemiology of sepsis. abstract: Sepsis continues to represent a major problem in intensive care units worldwide. Diagnosis and management are often complex due in part to the remarkably diverse nature of the septic patient. Indeed, sepsis can range in severity from mild systemic inflammation of little clinical importance through to a widespread severe inflammatory response with multiple organ failure and a mortality rate in excess of 50%. Sepsis can affect individuals of any age group, with no or multiple co-morbidities, and with many different ongoing diagnoses. It can occur as the result of infection by one or more of a multitude of microbial pathogens impacting on any of numerous different sites within the body. Given the huge complexity of sepsis and the diverse populations of patients it affects, simple definitions are of relatively little use and a more detailed framework which can be used to better characterize patients with sepsis has been proposed, much as the TNM classification (tumor size, nodal spread, metastases) has been successfully used in clinical oncology. In this chapter, we discuss the development of this PIRO system, and suggest how it may be used in the future to aid diagnosis, guide therapy, and improve prognostication. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121867/ doi: 10.1007/978-3-642-00479-7_1 id: cord-277178-nbotxv35 author: Vindrola-Padros, C. title: Remote home monitoring (virtual wards) during the COVID-19 pandemic: a living systematic review date: 2020-10-09 words: 5044.0 sentences: 307.0 pages: flesch: 51.0 cache: ./cache/cord-277178-nbotxv35.txt txt: ./txt/cord-277178-nbotxv35.txt summary: Objectives: The aim of this review was to analyse the implementation and impact of remote home monitoring models (virtual wards) during COVID-19, identifying their main components, processes of implementation, target patient populations, impact on outcomes, costs and lessons learnt. There is a paucity of published literature on the models of care developed to implement remote home monitoring across different healthcare contexts during the COVID-19 pandemic, the experiences of staff implementing these models and patients receiving care, the use of data for monitoring progress, resources required, as well as the impact of these models on clinical, process and economic outcomes. The included articles were analysed using a data extraction form developed in REDCap (Research Electronic Data Capture) that extracted data on: the design and general characteristics of the model, patient populations, main reported process and clinical outcomes and its potential economic impact. abstract: Objectives: The aim of this review was to analyse the implementation and impact of remote home monitoring models (virtual wards) during COVID-19, identifying their main components, processes of implementation, target patient populations, impact on outcomes, costs and lessons learnt. The review will be kept live through regular updates. Design: The review was designed as a living systematic review to capture a rapidly evolving evidence base. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Setting: The review included remote home monitoring models led by primary and secondary care across seven countries. Participants: 17 examples of remote home monitoring models were included in the review. Main outcome measures: Impact of remote home monitoring on virtual length of stay, escalation, Emergency department attendance, reattendance, admission, readmission and mortality. Results: The primary aim of the remote home monitoring models was the early identification of deterioration for patients self-managing COVID-19 symptoms at home. Most models were led by secondary care. Broad criteria for the eligible patient population were used and confirmation of COVID-19 was not required (in most cases). Monitoring was carried via online platforms, paper-based systems with telephone calls or (less frequently) through wearable sensors. We could not reach conclusions regarding patient safety and the identification of early deterioration due to lack of standardised reporting across articles and missing data. None of the articles reported any form of economic analysis, beyond how the resources were used. Conclusions: The review pointed to variability in the implementation of the models, in relation to healthcare sector, monitoring approach and selected outcome measures. Lack of standardisation on reporting prevented conclusions on the impact of remote home monitoring on patient safety or early escalation during COVID-19. Future research should focus on staff and patient experiences of care and potential inequalities in access to these models. Attention needs to be paid to the processes used to implement these models, the evaluation of their impact on patient outcomes through the use of comparators, the use of risk-stratification tools, and cost-effectiveness of the models and their sustainability. Protocol registration: The review protocol was published on PROSPERO (CRD: 42020202888). url: https://doi.org/10.1101/2020.10.07.20208587 doi: 10.1101/2020.10.07.20208587 id: cord-336790-29im4gxw author: Violetis, Odyssefs A. title: COVID-19 Infection and Haematological Involvement: a Review of Epidemiology, Pathophysiology and Prognosis of Full Blood Count Findings date: 2020-06-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The unfolding COVID-19 pandemic began in December 2019 in Wuhan, Hubei Province. COVID-19 is a systemic infection affecting several systems including the haematopoietic system. Surveys illustrating the laboratory findings of these patients conclude that lymphocytopenia, neutrophilia and thrombocytopenia are prominent amongst them. Moreover, it has been reported a significant decrease in T lymphocyte subsets and an increase of inflammatory cytokines of hospitalized patients with COVID-19. Generally, thrombocytopenia is commonplace in critically ill patients and usually suggests serious organ malfunction. In view of this, this review investigates the correlation between these abnormalities and the prognosis and disease course. Full blood count is an easy, economic and widely available tool which may help to discriminate between patients with or without severe disease. Last but not least, this review examines potential pathophysiological mechanisms by the novel coronavirus which contribute to these haematological alterations aiding the clinicians to better understand this disease and provide more clinical treatment options. url: https://www.ncbi.nlm.nih.gov/pubmed/32838152/ doi: 10.1007/s42399-020-00380-3 id: cord-332778-rf47ptj6 author: Vivarelli, Silvia title: Cancer Management during COVID-19 Pandemic: Is Immune Checkpoint Inhibitors-Based Immunotherapy Harmful or Beneficial? date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 (COVID-19) is currently representing a global health threat especially for fragile individuals, such as cancer patients. It was demonstrated that cancer patients have an increased risk of developing a worse symptomatology upon severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV-2) infection, often leading to hospitalization and intensive care. The consequences of this pandemic for oncology are really heavy, as the entire healthcare system got reorganized. Both oncologists and cancer patients are experiencing rescheduling of treatments and disruptions of appointments with a concurrent surge of fear and stress. In this review all the up-to-date findings, concerning the association between COVID-19 and cancer, are reported. A remaining very debated question regards the use of an innovative class of anti-cancer molecules, the immune checkpoint inhibitors (ICIs), given their modulating effects on the immune system. For that reason, administration of ICIs to cancer patients represents a question mark during this pandemic, as its correlation with COVID-19-associated risks is still under investigation. Based on the mechanisms of action of ICIs and the current evidence, we suggest that ICIs not only can be safely administered to cancer patients, but they might even be beneficial in COVID-19-positive cancer patients, by exerting an immune-stimulating action. url: https://doi.org/10.3390/cancers12082237 doi: 10.3390/cancers12082237 id: cord-332278-2p64ab2z author: Vivas, David title: Recomendaciones sobre el tratamiento antitrombótico durante la pandemia COVID-19. Posicionamiento del Grupo de Trabajo de Trombosis Cardiovascular de la Sociedad Española de Cardiología date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The new coronavirus SARS-CoV-2, which gives rise to the highly contagious COVID-19 disease, has caused a pandemic that is overwhelming health care systems worldwide. Affected patients have been reported to have a heightened inflammatory state that increases their thrombotic risk. However, there is very scarce information on the management of thrombotic risk, coagulation disorders, and anticoagulant therapy. In addition, the situation has also greatly influenced usual care in patients not infected with COVID-19. This article by the Working Group on Cardiovascular Thrombosis of the Spanish Society of Cardiology aims to summarize the available information and to provide a practical approach to the management of antithrombotic therapy. Full English text available from: www.revespcardiol.org/en url: https://www.ncbi.nlm.nih.gov/pubmed/32694078/ doi: 10.1016/j.rec.2020.04.025 id: cord-343773-9f7ew8uj author: Volo, T. title: Elective tracheostomy during COVID-19 outbreak: to whom, when, how? Early experience from Venice, Italy date: 2020-07-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: The need for prolonged invasive mechanical ventilation in COVID-19 patients is placing the otorhinolaryngologist in front of an increasing request for tracheostomy. Nowadays, there is uncertainty regarding the timing of tracheostomy, the prognosis of these patients and the safety of healthcare workers. The aim of this study is to evaluate the efficacy and safety of tracheostomy placement in patients with COVID-19. METHODS: A retrospective cohort study on 23 COVID 19 patients, to analyse the timing of tracheostomy, the risk factors associated with in-hospital death and the infection of the involved health care workers. Early tracheostomy was defined as ≤ 10 days and late ones > 10 days. RESULTS: The mortality rate of COVID-19 patients admitted to ICU that underwent tracheostomy was 18%. The overall mortality of patients admitted to ICU was 53%. The univariate analysis revealed that early tracheostomy, SOFA score > 6, and D-dimer level > 4 were significantly associated with a greater risk of death. At the multivariate analysis SOFA score > 6 and D-dimer level > 4 resulted as significant factors for a higher risk of death. No health care workers associated with tracheostomy are confirmed to be infected by SARS-CoV2. CONCLUSION: We suggest to wait at least 14 days to perform tracheostomy. In patients with SOFA score > 6 and D dimer > 4, tracheostomy should not be performed or should be postponed. Optimized procedures and enhanced personal protective equipment can make the tracheostomy safe and beneficial in COVID-19 patients. url: https://doi.org/10.1007/s00405-020-06190-6 doi: 10.1007/s00405-020-06190-6 id: cord-323713-bc00vths author: Volpi, Stefano title: Efficacy and Adverse Events During Janus Kinase Inhibitor Treatment of SAVI Syndrome date: 2019-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: Mutations affecting the TMEM173 gene cause STING-associated vasculopathy with onset in infancy (SAVI). No standard immunosuppressive treatment approach is able to control disease progression in patients with SAVI. We studied the efficacy and safety of targeting type I IFN signaling with the Janus kinase inhibitor, ruxolitinib. METHODS: We used DNA sequencing to identify mutations in TMEM173 in patients with peripheral blood type I IFN signature. The JAK1/2 inhibitor ruxolitinib was administered on an off-label basis. RESULTS: We identified three patients with SAVI presenting with skin involvement and progressive severe interstitial lung disease. Indirect echocardiographic signs of pulmonary hypertension were present in one case. Following treatment with ruxolitinib, we observed improvements of respiratory function including increased forced vital capacity in two patients, with discontinuation of oxygen therapy and resolution of echocardiographic abnormalities in one case. Efficacy was persistent in one patient and only transitory in the other two patients. Clinical control of skin complications was obtained, and one patient discontinued steroid treatment. One patient, who presented with kidney involvement, showed resolution of hematuria. One patient experienced increased recurrence of severe viral respiratory infections. Monitoring of peripheral blood type I interferon signature during ruxolitinib treatment did not show a stable decrease. CONCLUSIONS: We conclude that targeting type I IFN receptor signaling may represent a promising therapeutic option for a subset of patients with SAVI syndrome and severe lung involvement. However, the occurrence of viral respiratory infection might represent an important cautionary note for the application of such form of treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10875-019-00645-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/31144250/ doi: 10.1007/s10875-019-00645-0 id: cord-303787-dx1n8jap author: Vonck, Kristl title: Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 date: 2020-05-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported. The aim of this study was to perform a review to describe neurological manifestations in patients with COVID‐19 and possible neuro‐invasive mechanisms of Sars‐CoV‐2. METHODS: Pubmed, WebOfScience and Covid‐dedicated databases were searched for the combination of COVID‐19 terminology and neurology terminology up to May 10(th) 2020. Social media channels were followed‐up between March 15(th) and May 10(th) 2020 for postings with the same scope. Neurological manifestations were extracted from the identified manuscripts and combined to provide a useful summary for the neurologist in clinical practice. RESULTS: Neurological manifestations potentially related to COVID‐19 have been reported in large studies, case series and case reports and include acute cerebrovascular diseases, impaired consciousness, cranial nerve manifestations and auto‐immune disorders such as Guillain‐Barré Syndrome often present in patients with more severe COVID‐19. Cranial nerve symptoms such as olfactory and gustatory dysfunctions are highly prevalent in patients with mild‐to‐moderate COVID‐19 even without associated nasal symptoms and often present in an early stage of the disease. CONCLUSION: Physicians should be aware of the neurological manifestations in patients with COVID‐19, especially when rapid clinical deterioration occurs. The neurological symptoms in COVID‐19 patients may be due to direct viral neurological injury or indirect neuroinflammatory and autoimmune mechanisms. No antiviral treatments against the virus or vaccines for its prevention are available and the long‐term consequences of the infection on human health remain uncertain especially with regards to the neurological system. url: https://www.ncbi.nlm.nih.gov/pubmed/32416028/ doi: 10.1111/ene.14329 id: cord-013003-gxd29jxf author: Vora, Darshan title: Surgical management of a complex case of Charcot arthropathy of the spine: a case report date: 2019-08-22 words: 2262.0 sentences: 123.0 pages: flesch: 42.0 cache: ./cache/cord-013003-gxd29jxf.txt txt: ./txt/cord-013003-gxd29jxf.txt summary: INTRODUCTION: The authors present a case of a 55-year-old male with T10 complete paraplegia diagnosed with Charcot arthropathy of the spine (CAS). CAS is now a well-defined long-term complication following traumatic spinal cord injury (SCI), developing on average 17 years after injury. Here we describe the case of a patient with paraplegia who developed CAS following a traumatic SCI complicated by a complex hospital course. Autonomic dysreflexia associated with Charcot spine following spinal cord injury: a case report and literature review Charcot joint of the spine, a cause of autonomic dysreflexia in spinal cord injured patients Management of autonomic dysreflexia associated with Charcot spinal arthropathy in a patient with complete spinal cord injury: Case report and review of the literature Four-rod instrumentation for treatment of Charcot spinal arthropathy causing autonomic dysreflexia: case report and literature review abstract: INTRODUCTION: The authors present a case of a 55-year-old male with T10 complete paraplegia diagnosed with Charcot arthropathy of the spine (CAS). CASE PRESENTATION: He presented to an outside institution with vomiting and productive cough with subsequent computed tomography (CT) and MRI imaging revealing L5 osteomyelitis and a paraspinal abscess. Given the patient’s inability to remain in good posture in his wheelchair he underwent a multilevel vertebrectomy and thoracolumbar fusion. Due to multiple co-morbidities, surgical recovery was complex, ultimately requiring revision circumferential fixation. DISCUSSION: CAS is an uncommon, long-term complication of traumatic spinal cord injury (SCI). Surgical management is often complex and associated with significant complications. Currently, a consensus on CAS prevention, specific surgical fixation techniques and post-surgical nursing care management is lacking. In this case report we provide our experience in the management of a complex case of CAS to aid in decision making for future neurosurgeons who encounter this sequela of traumatic SCI. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786288/ doi: 10.1038/s41394-019-0217-5 id: cord-003198-1kw5v6rm author: Vuillard, Constance title: Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study date: 2018-09-11 words: 4851.0 sentences: 242.0 pages: flesch: 42.0 cache: ./cache/cord-003198-1kw5v6rm.txt txt: ./txt/cord-003198-1kw5v6rm.txt summary: The following data were collected on a standardized anonymized case record form: demographic characteristics (age, gender), severity scores upon ICU admission (Sequential Organ Failure Assessment [23] and Simplified Acute Physiology Score II [24] ), main comorbidities, delay between first respiratory sign and ICU admission, clinical examination (respiratory and extra-respiratory manifestations) and laboratory findings at the time of ICU admission (blood leukocytes and platelets counts, serum procalcitonine, C-reactive protein, creatine kinase and creatinine levels, PaO 2 /FiO 2 with FiO 2 calculated according to the following formula [25, 26] : FiO 2 = oxygen flow in liter per minute × 0.04 + 0.21 when standard oxygen was used), radiological findings on chest X-ray and CT scan, cytological and bacteriological analyses of broncho-alveolar lavage (BAL) fluid, type of positive autoantibodies (Jo-1, PL7, PL12, OJ, EJ, KS, Zo, YRS/Tyr/ Ha or aMDA-5), immunosuppressive treatments received (corticosteroids, cyclophosphamide, rituximab, basiliximab, tacrolimus, cyclosporine, methotrexate, intravenous immunoglobulins or plasma exchange), organ supports in the ICU (invasive mechanical ventilation, extra-corporeal membrane oxygenation (ECMO), renal replacement therapy, vasopressors), ICU and hospital length of stay, ICU and hospital mortality. abstract: BACKGROUND: Anti-synthetase (AS) and dermato-pulmonary associated with anti-MDA-5 antibodies (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies potentially responsible for severe acute interstitial lung disease. We undertook a 13-year retrospective multicenter study in 35 French ICUs in order to describe the clinical presentation and the outcome of patients admitted to the ICU for acute respiratory failure (ARF) revealing AS or aMDA-5 syndromes. RESULTS: From 2005 to 2017, 47 patients (23 males; median age 60 [1st–3rd quartiles 52–69] years, no comorbidity 85%) were admitted to the ICU for ARF revealing AS (n = 28, 60%) or aMDA-5 (n = 19, 40%) syndromes. Muscular, articular and cutaneous manifestations occurred in 11 patients (23%), 14 (30%) and 20 (43%) patients, respectively. Seventeen of them (36%) had no extra-pulmonary manifestations. C-reactive protein was increased (139 [40–208] mg/L), whereas procalcitonine was not (0.30 [0.12–0.56] ng/mL). Proportion of patients with creatine kinase ≥ 2N was 20% (n = 9/47). Forty-two patients (89%) had ARDS, which was severe in 86%, with a rate of 17% (n = 8/47) of extra-corporeal membrane oxygenation requirement. Proportion of patients who received corticosteroids, cyclophosphamide, rituximab, intravenous immunoglobulins and plasma exchange were 100%, 72%, 15%, 21% and 17%, respectively. ICU and hospital mortality rates were 45% (n = 21/47) and 51% (n = 24/47), respectively. Patients with aMDA-5 dermato-pulmonary syndrome had a higher hospital mortality than those with AS syndrome (n = 16/19, 84% vs. n = 8/28, 29%; p = 0.001). CONCLUSIONS: Intensivists should consider inflammatory myopathies as a cause of ARF of unknown origin. Extra-pulmonary manifestations are commonly lacking. Mortality is high, especially in aMDA-5 dermato-pulmonary syndrome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131681/ doi: 10.1186/s13613-018-0433-3 id: cord-033279-bcf9568a author: Vujaklija Brajković, Ana title: Utility of procalcitonin in a medical intensive care unit in Croatia date: 2020-10-06 words: 4013.0 sentences: 200.0 pages: flesch: 38.0 cache: ./cache/cord-033279-bcf9568a.txt txt: ./txt/cord-033279-bcf9568a.txt summary: Levels of PCT and CRP were significantly increased in patients with positive blood cultures, the infection caused by Gram-negative microorganism regardless of disease severity and pneumonia with complications. In the critical care setting, published studies differ greatly considering patient case mix [3] [4] [5] [6] [7] , the source of infection [3, 4, [6] [7] [8] [9] [10] [11] [12] [13] , the severity of the disease [4, 5, [10] [11] [12] 14] , exclusion criteria as well as cut-offs and laboratory methods for PCT measurements [3, 11, [13] [14] [15] . The PCT and CRP levels were significantly increased in patients with positive blood cultures, the infection caused by Gram-negative microorganism regardless of disease severity (no difference in SOFA and APACHE II scores), and pneumonia with complications (Table 3) . abstract: AIMS: To investigate the clinical benefit of routine procalcitonin (PCT) measurement in the medical intensive care unit (ICU) of a tertiary referral hospital. METHODS: Adult patients with suspected infections were included. White blood cells, C‑reactive protein (CRP), and PCT were measured. RESULTS: In this study 129 patients of median age 64 years (interquartile range 39–89 years) were prospectively included. The Acute Physiology And Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were 21 ± 14 and 7 ± 6, respectively. Intensive care unit (ICU) mortality was 22.5%. Immunocompromised patients constituted 39.5%. A significant correlation was observed between PCT and APACHE II (Spearman’s rho 0.461, p < 0.01), PCT and SOFA (Spearman’s rho 0.494, p < 0.01) and PCT and CRP (Spearman’s rho 0.403, p < 0.01). Most patients (n = 83, 64.3%) received antibiotics before admission. No difference in PCT (1.56 ± 8 µg/L vs. 1.44 ± 13 µg/L, p = 0.6) was observed with respect to previous antibiotic therapy. Levels of PCT and CRP were significantly increased in patients with positive blood cultures, the infection caused by Gram-negative microorganism regardless of disease severity and pneumonia with complications. PCT did not differ among patients with positive vs negative urine culture (4.6 ± 16 µg/L vs. 1.76 ± 11.9 µg/L) or positive vs. negative endotracheal aspirate (1.93 ± 11.4 µg/L vs. 1.76 ± 1.11 µg/L). PCT-guided stewardship was applied in 36 patients (28%). CONCLUSION: Increased initial PCT levels might point to the development of more severe disease caused by Gram-negative bacteria, regardless of previous antibiotic treatment. The results pertain to immunocompetent and immunocompromised patients. Implementation of PCT-guided stewardship in those patients is possible and relies on experience as well as knowledge of reference change value for a marker within the specific setting. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538271/ doi: 10.1007/s00508-020-01747-1 id: cord-263031-cco2vh0f author: Vultaggio, Alessandra title: Considerations on Biologicals for Patients with allergic disease in times of the COVID‐19 pandemic: an EAACI Statement date: 2020-06-05 words: 2870.0 sentences: 177.0 pages: flesch: 41.0 cache: ./cache/cord-263031-cco2vh0f.txt txt: ./txt/cord-263031-cco2vh0f.txt summary: We discuss immunological and clinical considerations for patients on biologic agents (biologicals)targeting the type 2 inflammatory response due to difficult-to-treat allergic diseases in the context of COVID-19. In other coronavirus infections such as severe acute respiratory syndrome (SARS), type I IFN are critical for the initiation of immune response and virus clearance. In line with a paucity of mechanistic data on COVID-19 in the context of type 2 inflammation, knowledge on the disease course in patients treated with biologicals targeting type 2 inflammation due to severe asthma or other atopic diseases, such as CSU, AD and CRSwNP, is scarce to absent. In the past years, new biological therapies for severe asthma, atopic dermatitis (AD), chronicrhinosinusitis with nasal polyps (CRSwNP) and chronic spontaneous urticaria (CSU) have been developed targeting different aspects of the type 2 immune response. abstract: The outbreak of the SARS‐CoV‐2‐induced Coronavirus Disease 2019 (COVID‐19) pandemic re‐shaped doctor‐patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related to the fact that the exact sequence of immunological events during SARS‐CoV‐2 is not known. Severe COVID‐19 patients may experience a “cytokine storm” and associated organ damage characterized by an exaggerated release of proinflammatory type 1 and type 3 cytokines. These inflammatory responses are potentially counteracted by anti‐inflammatory cytokines and type 2 responses. This expert based EAACI statement aims to provide guidance on the application of biologicals targeting type 2 inflammation in patients with allergic disease. Currently, there is very little evidence for an enhanced risk of patients with allergic diseases to develop severe COVID‐19 with studies focusing on severe allergic phenotypes lacking. At present, non‐infected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self‐application. In case of an active SARS‐CoV‐2 infection, biological treatment needs to be stopped until clinical recovery and SARS‐CoV‐2 negativity is established and treatment with biologicals should be re‐initiated. Maintenance of add‐on therapy and a constant assessment of disease control, apart from acute management is demanded. url: https://www.ncbi.nlm.nih.gov/pubmed/32500526/ doi: 10.1111/all.14407 id: cord-348975-plne3xlz author: Wagner, Tyler title: Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis date: 2020-07-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Understanding temporal dynamics of COVID-19 symptoms could provide fine-grained resolution to guide clinical decision-making. Here, we use deep neural networks over an institution-wide platform for the augmented curation of clinical notes from 77,167 patients subjected to COVID-19 PCR testing. By contrasting Electronic Health Record (EHR)-derived symptoms of COVID-19-positive (COVID(pos); n = 2,317) versus COVID-19-negative (COVID(neg); n = 74,850) patients for the week preceding the PCR testing date, we identify anosmia/dysgeusia (27.1-fold), fever/chills (2.6-fold), respiratory difficulty (2.2-fold), cough (2.2-fold), myalgia/arthralgia (2-fold), and diarrhea (1.4-fold) as significantly amplified in COVID(pos) over COVID(neg) patients. The combination of cough and fever/chills has 4.2-fold amplification in COVID(pos) patients during the week prior to PCR testing, in addition to anosmia/dysgeusia, constitutes the earliest EHR-derived signature of COVID-19. This study introduces an Augmented Intelligence platform for the real-time synthesis of institutional biomedical knowledge. The platform holds tremendous potential for scaling up curation throughput, thus enabling EHR-powered early disease diagnosis. url: https://www.ncbi.nlm.nih.gov/pubmed/32633720/ doi: 10.7554/elife.58227 id: cord-001322-7xmxcm35 author: Walden, Andrew P title: Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort date: 2014-04-01 words: 4286.0 sentences: 227.0 pages: flesch: 47.0 cache: ./cache/cord-001322-7xmxcm35.txt txt: ./txt/cord-001322-7xmxcm35.txt summary: Phenotypic data was recorded using a robust clinical database allowing a contemporary analysis of the clinical characteristics, microbiology, outcomes and independent risk factors in patients with severe CAP admitted to ICUs across Europe. A number of more recent, larger studies have focussed on identifying patients with CAP at increased risk of severe sepsis and death, as well as those who may require ventilator or vasopressor support [3, [24] [25] [26] . The aim of the study reported here was to define the clinical characteristics, microbiological aetiology, outcomes and independent risk factors for mortality in a large, contemporary cohort of patients with severe CAP admitted to ICUs across Europe. The British Thoracic Society Research Committee and The Public HealthLaboratory Service: The aetiology, management and outcome of severe community-acquired pneumonia on the intensive care unit A five-year study of severe community-acquired pneumonia with emphasis on prognosis in patients admitted to an intensive care unit abstract: INTRODUCTION: Community acquired pneumonia (CAP) is the most common infectious reason for admission to the Intensive Care Unit (ICU). The GenOSept study was designed to determine genetic influences on sepsis outcome. Phenotypic data was recorded using a robust clinical database allowing a contemporary analysis of the clinical characteristics, microbiology, outcomes and independent risk factors in patients with severe CAP admitted to ICUs across Europe. METHODS: Kaplan-Meier analysis was used to determine mortality rates. A Cox Proportional Hazards (PH) model was used to identify variables independently associated with 28-day and six-month mortality. RESULTS: Data from 1166 patients admitted to 102 centres across 17 countries was extracted. Median age was 64 years, 62% were male. Mortality rate at 28 days was 17%, rising to 27% at six months. Streptococcus pneumoniae was the commonest organism isolated (28% of cases) with no organism identified in 36%. Independent risk factors associated with an increased risk of death at six months included APACHE II score (hazard ratio, HR, 1.03; confidence interval, CI, 1.01-1.05), bilateral pulmonary infiltrates (HR1.44; CI 1.11-1.87) and ventilator support (HR 3.04; CI 1.64-5.62). Haematocrit, pH and urine volume on day one were all associated with a worse outcome. CONCLUSIONS: The mortality rate in patients with severe CAP admitted to European ICUs was 27% at six months. Streptococcus pneumoniae was the commonest organism isolated. In many cases the infecting organism was not identified. Ventilator support, the presence of diffuse pulmonary infiltrates, lower haematocrit, urine volume and pH on admission were independent predictors of a worse outcome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056764/ doi: 10.1186/cc13812 id: cord-253189-uba6dy08 author: Walker, Katie title: The evidence base for scribes and the disruptions of COVID-19 date: 2020-09-21 words: 1700.0 sentences: 108.0 pages: flesch: 57.0 cache: ./cache/cord-253189-uba6dy08.txt txt: ./txt/cord-253189-uba6dy08.txt summary: There has been a major expansion of scribe programs in the United States of America (USA) both in terms of their employment locations, now moving outside the emergency department (ED), and numbers, despite attempts to streamline documentation in electronic health records (EHRs) so that clerical support is no longer required. Many studies note that physicians go home soon after completion of their shift when working with a scribe but can''t report the magnitude of the impact. Impact of COVID19 on scribe programs 2020 has provided significant challenges for EM and for all other medical settings as well. In summary, there is now some limited economic evidence for using scribes, with small improvements seen in physician productivity and increased per-patient revenue in the USA, but not patient flow. Impact of scribes on emergency medicine doctors'' productivity and patient throughput: multicentre randomised trial An economic evaluation of the costs of training a medical scribe to work in Emergency Medicine abstract: Gottleib et al present a systematic review with some economic evidence for using scribes. Improvements are seen in physician productivity and increased per-patient revenue in the United States of America, but not patient flow. The improvements are relatively small and this may or may not be economic for a facility depending on the location, true costs and gains/losses of the scribe program. Scribes are well tolerated by patients and most physicians have a better experience when allocated a scribe. There are gaps in our knowledge regarding scribes, including total costs of programs, quality and safety information, whether scribes reduce physician burnout and the impact of the role on the scribe. Scribe roles and locations of work have changed during the COVID-19 period. Future research should explore how best to spend health dollars to improve patient access to skilled providers in a timely fashion, including comparisons of various provider roles and explorations of how to make health information technologies work better for the end user. url: https://www.sciencedirect.com/science/article/pii/S0196064420312117?v=s5 doi: 10.1016/j.annemergmed.2020.09.438 id: cord-313528-rp15vi1o author: Wallace, Douglas W. title: An adapted emergency department triage algorithm for the COVID‐19 pandemic date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The novel coronavirus disease 2019 (COVID‐19) pandemic, with its public health implications, high case fatality rate, and strain on hospital resources, will continue to challenge clinicians and researchers alike for months to come. Accurate triage of patients during the pandemic will assign patients to the appropriate level of care, provide the best care for the maximum number of patients, rationally limit personal protective equipment (PPE) usage, and mitigate nosocomial exposures. The authors describe an adapted COVID‐19 pandemic triage algorithm for emergency departments (EDs) guided by the best available evidence and responses to prior pandemics, with recommendations for clinician PPE use for each level of encounter in the setting of an ongoing PPE shortage. Our algorithm adheres to Centers for Disease Control and Prevention guidelines and supports discharge of patients with mild symptoms coupled with explicit and strict return precautions and infection control education. url: https://doi.org/10.1002/emp2.12210 doi: 10.1002/emp2.12210 id: cord-007788-09t52zix author: Wallhult, Elisabeth title: Early and Acute Complications and the Principles of HSCT Nursing Care date: 2017-11-22 words: 13962.0 sentences: 766.0 pages: flesch: 46.0 cache: ./cache/cord-007788-09t52zix.txt txt: ./txt/cord-007788-09t52zix.txt summary: Some other relatively rare complications are also covered here: haemorrhagic cystitis (HC), endothelial damage (ED) syndromes including engraftment syndrome (ES), idiopathic pneumonia syndrome (IPS), diffuse alveolar haemorrhage (DAH), transplant-associated microangiopathy (TAM) and sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). Oral damage may be a hallmark of graft versus host disease (GvHD) in patients following allogeneic stem cell transplantation, and the presence of lichenoid hyperkeratotic plaques (diagnostic sign), gingivitis, mucositis, erythema, pain, xerostomia and ulcers may indicate GvHD. The increased risk of infections in patients undergoing haematopoietic stem cell transplantation (HSCT) is well known, and infection is a leading cause of morbidity and mortality. Differential diagnoses will need to be excluded by assessing risk factors, symptoms and lab tests since liver dysfunction can also be seen in sepsis, viral infection, graft versus host disease (GvHD) and iron overload and as a side effect from many of the drugs used in the HSCT setting. abstract: Haematopoietic stem cell transplantation (HSCT) generally includes preparative or conditioning regimes containing chemotherapy and/or radiotherapy in high doses. These regimens, as well as other treatments before and after HSCT such as immunosuppressive drugs to prevent graft versus host disease (GvHD) (see Chap. 11), may affect the patient’s organs and tissues and may cause both acute and long-term complications. In the evolving field of stem cell therapies, some complications that traditionally have been regarded as early complications are now, due to changes in preparative regimens and choice of stem cell source, sometimes seen later in the post-transplant out-patient setting. The complications covered in this chapter generally occur within 100 days post HSCT and are thus classified as early complications. Two of the most common early complications are oral complications/mucositis and sepsis. Some other relatively rare complications are also covered here: haemorrhagic cystitis (HC), endothelial damage (ED) syndromes including engraftment syndrome (ES), idiopathic pneumonia syndrome (IPS), diffuse alveolar haemorrhage (DAH), transplant-associated microangiopathy (TAM) and sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). For all complications, recommendations for prevention and principles for nursing care are presented since careful nursing monitoring, prompt intervention and care may have an influence on patients’ morbidity and mortality. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123335/ doi: 10.1007/978-3-319-50026-3_9 id: cord-257717-fbfe5vt4 author: Wallis, Christopher J.D. title: The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future date: 2020-09-04 words: 7908.0 sentences: 371.0 pages: flesch: 35.0 cache: ./cache/cord-257717-fbfe5vt4.txt txt: ./txt/cord-257717-fbfe5vt4.txt summary: EVIDENCE ACQUISITION: A collaborative narrative review was conducted using literature published through May 2020 (PubMed), which comprised three main topics: reduced in-person interactions arguing for increasing virtual and image-based care, optimisation of the delivery of care, and the effect of COVID-19 in health care facilities on decision-making by patients and their families. Several themes emerged during the COVID-19 pandemic that would be critical or beneficial to genitourinary cancer care in the future ( Fig. 1) : first, reduced in-person interactions argued for increasing virtual and image-based care; second, optimising the delivery of care to include better triage, understanding and addressing mental health implications due to less in-person care, and maintaining high-quality research and education endeavours are necessary; and third, the presence of SARS-CoV-2 in health care facilities may affect decision-making by patients and their families. abstract: CONTEXT: The coronavirus disease 2019 (COVID-19) pandemic necessitated rapid changes in medical practice. Many of these changes may add value to care, creating opportunities going forward. OBJECTIVE: To provide an evidence-informed, expert-derived review of genitourinary cancer care moving forward following the initial COVID-19 pandemic. EVIDENCE ACQUISITION: A collaborative narrative review was conducted using literature published through May 2020 (PubMed), which comprised three main topics: reduced in-person interactions arguing for increasing virtual and image-based care, optimisation of the delivery of care, and the effect of COVID-19 in health care facilities on decision-making by patients and their families. EVIDENCE SYNTHESIS: Patterns of care will evolve following the COVID-19 pandemic. Telemedicine, virtual care, and telemonitoring will increase and could offer broader access to multidisciplinary expertise without increasing costs. Comprehensive and integrative telehealth solutions will be necessary, and should consider patients’ mental health and access differences due to socioeconomic status. Investigations and treatments will need to maximise efficiency and minimise health care interactions. Solutions such as one stop clinics, day case surgery, hypofractionated radiotherapy, and oral or less frequent drug dosing will be preferred. The pandemic necessitated a triage of those patients whose treatment should be expedited, delayed, or avoided, and may persist with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in circulation. Patients whose demographic characteristics are at the highest risk of complications from COVID-19 may re-evaluate the benefit of intervention for less aggressive cancers. Clinical research will need to accommodate virtual care and trial participation. Research dissemination and medical education will increasingly utilise virtual platforms, limiting in-person professional engagement; ensure data dissemination; and aim to enhance patient engagement. CONCLUSIONS: The COVID-19 pandemic will have lasting effects on the delivery of health care. These changes offer opportunities to improve access, delivery, and the value of care for patients with genitourinary cancers but raise concerns that physicians and health administrators must consider in order to ensure equitable access to care. PATIENT SUMMARY: The coronavirus disease 2019 (COVID-19) pandemic has dramatically changed the care provided to many patients with genitourinary cancers. This has necessitated a transition to telemedicine, changes in threshold or delays in many treatments, and an opportunity to reimagine patient care to maintain safety and improve value moving forward. url: https://api.elsevier.com/content/article/pii/S030228382030676X doi: 10.1016/j.eururo.2020.08.030 id: cord-289008-c4cu3vrp author: Wallis, Christopher J.D. title: Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic date: 2020-05-03 words: 9353.0 sentences: 446.0 pages: flesch: 44.0 cache: ./cache/cord-289008-c4cu3vrp.txt txt: ./txt/cord-289008-c4cu3vrp.txt summary: Patients with muscle-invasive bladder cancer are at risk of disease progression, with radical cystectomy delays beyond 12 wk from diagnosis or completion of neoadjuvant chemotherapy. To this end, PubMed was searched from inception until April 2, 2020 to identify studies examining the association between delays in treatment and clinical outcomes, including upstaging, recurrence, and mortality for patients with bladder cancer (BC; both muscle-invasive and non-muscle-invasive disease), prostate cancer (PCa), kidney cancer, upper tract urothelial cancer, germ cell tumors, and penile cancer. Where radiotherapy is planned to be administered, a recent Cochrane Database systematic review and meta-analysis of 10 studies including 8278 patients demonstrated that for those with intermediate-and high-risk PCa, hypofractionation is associated with equivalent oncologic outcomes (MFS, disease-specific survival, and OS), as well as functional outcomes [64] . abstract: CONTEXT: The coronavirus disease 2019 (COVID-19) pandemic is leading to delays in the treatment of many urologic cancers. OBJECTIVE: To provide a contemporary picture of the risks from delayed treatment for urologic cancers to assist with triage. EVIDENCE ACQUISITION: A collaborative review using literature published as of April 2, 2020. EVIDENCE SYNTHESIS: Patients with low-grade non–muscle-invasive bladder cancer are unlikely to suffer from a 3–6-month delay. Patients with muscle-invasive bladder cancer are at risk of disease progression, with radical cystectomy delays beyond 12 wk from diagnosis or completion of neoadjuvant chemotherapy. Prioritization of these patients for surgery or management with radiochemotherapy is encouraged. Active surveillance should be used for low-risk prostate cancer (PCa). Treatment of most patients with intermediate- and high-risk PCa can be deferred 3–6 mo without change in outcomes. The same may be true for cancers with the highest risk of progression. With radiotherapy, neoadjuvant androgen deprivation therapy (ADT) is the standard of care. For surgery, although the added value of neoadjuvant ADT is questionable, it may be considered if a patient is interested in such an approach. Intervention may be safely deferred for T1/T2 renal masses, while locally advanced renal tumors (≥T3) should be treated expeditiously. Patients with metastatic renal cancer may consider vascular endothelial growth factor targeted therapy over immunotherapy. Risks for delay in the treatment of upper tract urothelial cancer depend on grade and stage. For patients with high-grade disease, delays of 12 wk in nephroureterectomy are not associated with adverse survival outcomes. Expert guidance recommends expedient local treatment of testis cancer. In penile cancer, adverse outcomes have been observed with delays of ≥3 mo before inguinal lymphadenectomy. Limitations include a paucity of data and methodologic variations for many cancers. CONCLUSIONS: Patients and clinicians should consider the oncologic risk of delayed cancer intervention versus the risks of COVID-19 to the patient, treating health care professionals, and the health care system. PATIENT SUMMARY: The coronavirus disease 2019 pandemic has led to delays in the treatment of patients with urologic malignancies. Based on a review of the literature, patients with high-grade urothelial carcinoma, advanced kidney cancer, testicular cancer, and penile cancer should be prioritized for treatment during these challenging times. url: https://www.sciencedirect.com/science/article/pii/S0302283820303316?v=s5 doi: 10.1016/j.eururo.2020.04.063 id: cord-007865-1oyl6clq author: Walsh, Paul title: Patients Would Prefer Ward to Emergency Department Boarding While Awaiting an Inpatient Bed date: 2008-02-21 words: 2437.0 sentences: 135.0 pages: flesch: 58.0 cache: ./cache/cord-007865-1oyl6clq.txt txt: ./txt/cord-007865-1oyl6clq.txt summary: title: Patients Would Prefer Ward to Emergency Department Boarding While Awaiting an Inpatient Bed Boarding of admitted patients in the Emergency Department (ED), rather than in inpatient care areas, is widespread. The practice of holding admitted patients in the Emergency Department (ED) until an inpatient bed becomes available (commonly called "boarding") is widespread (1, 2) . These were convenience samples (dependent on research assistant [RA] availability) of 1) patients waiting to be seen without a disposition, 2) visitors of patients, and 3) admitted patients who were being held in the ED while awaiting an inpatient bed. The purpose of sampling these three groups was to determine the opinion of members of the general public with an immediate interest in the subject (visitors), non-boarding patients, and those patients who were actually being boarded in the ED. Emergency department overcrowding: patient preference for boarding hallway location abstract: Boarding of admitted patients in the Emergency Department (ED), rather than in inpatient care areas, is widespread. We surveyed boarded patients, patients without a disposition, and visitors at a county hospital ED serving a mixed urban and rural population. Subjects were asked “If you needed to be admitted to the hospital but no inpatient bed is available, would you prefer to be kept in an ER hallway or a hallway on an inpatient ward?” Boarded patients said they would prefer ward to ED boarding, 117/213 (54.9%; 95% confidence interval [CI] 48.0%–61.7%). Patients without a disposition 314/477 (65.8%; 95% CI 61.4%–70.0%) and visitors 370/532 (69.5%; 95% CI 65.4%–73.4%) stated a preference for ward boarding in 314/477 (65.8%; 95% CI 61.4%–70.0%) and in 370/532 (69.5%; 95% CI 65.4%–73.4%), respectively. Common reasons for preferring inpatient ward boarding were privacy concerns and reduced noise levels. Those preferring ED boarding valued easy access to a doctor. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125793/ doi: 10.1016/j.jemermed.2007.05.012 id: cord-017772-zpf1xjqi author: Walter, James M. title: Thrombocytopenia in the Intensive Care Unit date: 2019-07-24 words: 4577.0 sentences: 279.0 pages: flesch: 43.0 cache: ./cache/cord-017772-zpf1xjqi.txt txt: ./txt/cord-017772-zpf1xjqi.txt summary: In general, ICU patients who develop thrombocytopenia are sicker than patients with normal platelet counts, with higher illness severity scores, more need for vasoactive infusions, and more organ dysfunction [8, 9] . TMAs are a diverse group of disorders that can be classified broadly as primary (thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, drug-mediated, etc.) or secondary to a systemic disorder (disseminated intravascular coagulation, severe hypertension, hemolysis with elevated liver enzymes and low platelets during pregnancy, etc.) [23] . The diagnosis of DIC should be suspected in any critically ill patient with thrombocytopenia, abnormal coagulation parameters (e.g., a prolonged prothrombin and partial thromboplastin times), MAHA, and laboratory evidence of fibrinolysis (e.g., an elevated d-dimer and reduced fibrinogen) [38] . Indeed, a recent systematic review did not identify a single high-quality study that investigated the impact of prophylactic platelet transfusions on bleeding rates in critically ill patients [72] . abstract: The evaluation and management of thrombocytopenia is a daily challenge for clinicians in the intensive care unit (ICU). Thrombocytopenia is incredibly common, present in upwards of 60% of ICU patients. Additionally, thrombocytopenia in the critically ill is rarely caused by a single etiology. Several causes of thrombocytopenia in the ICU including heparin-induced thrombocytopenia (HIT) and thrombotic thrombocytopenic purpura demand urgent recognition and intervention. This chapter provides a general overview of thrombocytopenia in the ICU and highlights important diagnostic and management considerations for some of the most common etiologies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122430/ doi: 10.1007/978-3-030-26710-0_83 id: cord-335795-hdko0zdw author: Wamsley, Christine E title: Trends and Challenges of Telehealth in an Academic Institution: The Unforeseen Benefits of the COVID-19 Global Pandemic date: 2020-07-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has necessitated a reorganization of healthcare delivery, shedding light on the many unrealized advantages telehealth has to offer. In addition to facilitating social distancing, minimizing the risk of pathogen exposure, and preserving healthcare resources, there are many benefits of utilizing this platform that can extend beyond the current pandemic, which will change the way healthcare is delivered for generations to come. With the rapid expansion of telehealth, we present data from our high-volume academic institution’s telehealth efforts, with a more focused analysis of plastic surgery. Although state legislation regarding telehealth varies greatly, we discuss challenges such as legal issues, logistical constraints, privacy concerns, and billing. We also discuss various advantages and the future direction of telehealth not only for plastic surgery but also its general utilization for the future of medicine in the United States. url: https://doi.org/10.1093/asj/sjaa212 doi: 10.1093/asj/sjaa212 id: cord-351762-n95ar9ci author: Wang, Brian Xiangzhi title: Susceptibility and prognosis of COVID-19 patients with cardiovascular disease date: 2020-06-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1136/openhrt-2020-001310 doi: 10.1136/openhrt-2020-001310 id: cord-274331-0i2opmcn author: Wang, Catherine J. title: COVID‐19 infection on IL‐23 inhibition date: 2020-07-14 words: 388.0 sentences: 32.0 pages: flesch: 53.0 cache: ./cache/cord-274331-0i2opmcn.txt txt: ./txt/cord-274331-0i2opmcn.txt summary: Given mild symptoms, the patient was discharged. The patient was discharged 1 week later on home quarantine. The patient in this manuscript has given informed consent to publication of his case details. In our case, the patient recovered from COVID-19 before his next scheduled risankizumab dose. However, more data needs to be obtained about biologics in COVID-19 patients, in particular whether or not biologic dosage timeline should be adjusted based on resolution of infection. A database to collect information on COVID-19 patients on biologic therapy and their outcomes would be instrumental to guide clinicians on best practices for now and in future pandemics. In conclusion, this case illustrates that IL-23 inhibition via biologic therapy in COVID-19 may not correlate with severe respiratory disease. TH17 responses in cytokine storm of COVID-19: an emerging target of JAK2 inhibitor Fedratinib SARS-CoV-2 infection in a psoriatic patient treated with IL-23 inhibitor abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32584451/ doi: 10.1111/dth.13893 id: cord-255490-gyq6cpc9 author: Wang, Chang‐Zheng title: Early risk factors of the exacerbation of Coronavirus disease 2019 pneumonia date: 2020-05-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The purpose of this study was to investigate the early risk factors for the exacerbation of coronavirus disease 2019 (COVID‐19) pneumonia. Restrospective analysis of clinical data of 85 patients infected with SARS‐CoV‐2, including gender, age, comorbidities, symptoms, blood routine, clotting profile, biochemical examination, albumin, myocardial enzyme profile, inflammatory markers, and chest CT. All laboratory examination were measured within first 24 hours after admission, and chest CT were performed before admission. 56 (65.9%) patients had a history of exposure to Huanan seafood market in Wuhan. Fever and dry cough accounted for the highest percentage of all symptoms. Male COVID‐2019 patients were more likely to develop severe pneumonia. Patients with severe and critical conditions are older and have higher rates of hypertension (p=0.003) and coronary heart disease (p=0.017). All severe and critical patients infected with SARS‐CoV‐2 showed bilateral lung involvement and have more multiple lobes involvement than common patients (p<0.001). Severe and critical patients showed higher WBC count (p=0.006), NEU count (p=0.001), NEU% (p=0.002), PCT (p=0.011), CRP (p=0.003), PT (p=0.035), D‐dimer (p=0.025), AST (p=0.006), and lower LYM count (p=0.019), LYM% (p=0.001), ALB (p<0.001). Logistic regression analysis showed NEU count is a independent risk factor for deterioration, with the threshold of 6.5×10(9)·L(‐1). We concluded that the laboratory independent risk factor for the progression of COVID‐19 pneumonia is NEU count. In addition, COVID‐19 patients with bilateral lung involvement or multiple lobes involvement should be taken seriously and actively treated to prevent deterioration of the disease. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32470167/ doi: 10.1002/jmv.26071 id: cord-335719-tnimrff9 author: Wang, Chia-shi title: eHealth in kidney care date: 2020-04-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: eHealth is gaining momentum in nephrology, although evidence for its efficacy remains unclear and challenges to its widespread adoption persist. Successful integration of eHealth into kidney care will require patient engagement to develop effective interventions and issues such as data validity, regulation, oversight and adequate infrastructure to be addressed. url: https://www.ncbi.nlm.nih.gov/pubmed/32238923/ doi: 10.1038/s41581-020-0271-z id: cord-320788-ln8ddyuj author: Wang, Chun-Hua title: Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS date: 2005-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: During the acute phase of severe acute respiratory syndrome (SARS), mononuclear cells infiltration, alveolar cell desquamation and hyaline membrane formation have been described, together with dysregulation of plasma cytokine levels. Persistent high-resolution computed tomography (HRCT) abnormalities occur in SARS patients up to 40 days after recovery. METHODS: To determine further the time course of recovery of lung inflammation, we investigated the HRCT and inflammatory profiles, and coronavirus persistence in bronchoalveolar lavage fluid (BALF) of 12 patients at recovery at 60 and 90 days. RESULTS: At 60 days, compared to normal controls, SARS patients had increased cellularity of BALF with increased alveolar macrophages (AM) and CD8 cells. HRCT scores were increased and correlated with T-cell numbers and their subpopulations, and inversely with CD4/CD8 ratio. TNF-α, IL-6, IL-8, RANTES and MCP-1 levels were increased. Viral particles in AM were detected by electron microscopy in 7 of 12 SARS patients with high HRCT score. On day 90, HRCT scores improved significantly in 10 of 12 patients, with normalization of BALF cell counts in 6 of 12 patients with repeat bronchoscopy. Pulse steroid therapy and prolonged fever were two independent factors associated with delayed resolution of pneumonitis, in this non-randomized, retrospective analysis. CONCLUSION: Resolution of pneumonitis is delayed in some patients during SARS recovery and may be associated with delayed clearance of coronavirus, Complete resolution may occur by 90 days or later. url: https://www.ncbi.nlm.nih.gov/pubmed/15888207/ doi: 10.1186/1465-9921-6-42 id: cord-000716-fhm8abxp author: Wang, Hao title: Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics date: 2012-07-11 words: 2770.0 sentences: 154.0 pages: flesch: 45.0 cache: ./cache/cord-000716-fhm8abxp.txt txt: ./txt/cord-000716-fhm8abxp.txt summary: BACKGROUND: In the present study, the whole human genome oligo microarray was employed to investigate the gene expression profile in symptomatic pulmonary embolism (PE). Gene Ontology analysis showed the genes with down-regulated expressions mainly explain the compromised T cell immunity. However, mRNA expression of P-selectin (mainly distributed on the surface of ECs and platelets) and E-selection (mainly distributed on the surface of activated ECs) are not elevated in PE group which indicate venous endothelial cells are not impaired in patients with PE (Fig.2) . Gene ontology analysis exhibited compromised T cell mediated immune function, and t test indicated associated genes were significantly down-regulated in patients with PE than in control groups. Two genes with down-regulated expressions are closely related to the T cell mediated immunity according to GO analysis (with high value of Enrichment). Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study abstract: BACKGROUND: In the present study, the whole human genome oligo microarray was employed to investigate the gene expression profile in symptomatic pulmonary embolism (PE). METHODS: Twenty patients with PE and 20 age and gender matched patients without PE as controls were enrolled into the present study in the same period. The diagnosis of PE was based on the clinical manifestations and findings on imaging examinations. Acute arterial and/or venous thrombosis was excluded in controls. The whole human genome oligo microarray was employed for detection. Statistical analysis was performed with t test following analysis of very small samples of repeated measurements and Gene Ontology (GO) analysis. RESULTS: Genomic data showed no damage to vascular endothelial cells in PE patients. Genomic data only found increased mRNA expression of a small amount of coagulation factors in PE patients. In the PE group, anticoagulant proteins, Fibrinolytic system and proteins related to platelet functions only played partial roles in the pathogenesis of PE. In addition, the mRNA expressions of a fraction of adhesion molecules were markedly up-regulated. Gene Ontology analysis showed the genes with down-regulated expressions mainly explain the compromised T cell immunity. Symptomatic VTE patients have compromised T cell immunity. CONCLUSION: The damage to vascular endothelial cells is not necessary in the pathogenesis of VTE, and only a fraction of factors involved in the shared coagulation cascade are activated. Genomic results may provide a new clue for clinical diagnosis, treatment and prevention of VTE. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399218/ doi: 10.7150/ijms.4641 id: cord-323761-9m177ozm author: Wang, Huijie title: Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety date: 2020-02-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Asthma in pregnancy is a health issue of great concern. Physiological changes and drug compliance during pregnancy can affect asthma control in varying degrees, and the control level of asthma and the side effects of asthma medications are closely related to the adverse perinatal outcomes of mother and fetus. This article provides an update on the available literature regarding the alleviating or aggravating mechanism of asthma in pregnancy, diagnosis, disease assessment, and systematic management, to provide a new guidance for physician, obstetric joint doctor, and health care practitioner. url: https://www.ncbi.nlm.nih.gov/pubmed/32184907/ doi: 10.1155/2020/9046842 id: cord-291388-tt9eq7e0 author: Wang, Jann-Tay title: Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients date: 2004-05-17 words: 4355.0 sentences: 226.0 pages: flesch: 50.0 cache: ./cache/cord-291388-tt9eq7e0.txt txt: ./txt/cord-291388-tt9eq7e0.txt summary: Previous reports have described some major clinical findings of SARS, including the temporal progression of clinical symptoms and chest radiography, the outcomes, suggested treatment protocol, and risk factors for death (4, 5) . We report on the clinical features of our SARS patients with pneumonia, with emphasis on temporal progression of laboratory findings, treatment outcome, and risk factors for poor prognosis. Methylprednisolone was usually administered in the second week of the disease if any of the following occurred: a flare of fever, progression of clinical symptoms (such as dyspnea or diarrhea), a surge or resurge of CRP level, or rapid deterioration of chest radiographic findings (development of new infiltration). A previous study reported the temporal progression of clinical and radiologic findings in SARS patients and indicated that several parameters would become more severe in the second and third week of disease (5). abstract: Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death. url: https://www.ncbi.nlm.nih.gov/pubmed/15200814/ doi: 10.3201/eid1005.030640 id: cord-325628-pa3dkz2f author: Wang, Jinsong title: Strategy for treating vascular emergencies during the COVID-19 pandemic in China date: 2020-06-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus-caused pneumonia (COVID-19) broke out in Dec 2019. The virus soon proved to be extremely contagious and caused an international pandemic. Clinicians treating COVID-19 patients face considerable danger of occupational exposure due to the highly infectious nature of the virus and precautions must be taken to prevent medical staff infections. This article lists important measures that may save the lives of patients and medical staff during the COVID-19 pandemic and help to stop the transmission of COVID-19 on hospital grounds. The suggestions include: 1. Establishing detailed Infection Control and Prevention Protocols in the operating room; 2. Expediting testing procedures and patient screening for COVID-19; 3. Utilizing case-specific treatment planning for vascular patients with COVID-19, favoring minimally invasive methods; 4. Establishing and reinforcing protective awareness within medical personnel. url: https://api.elsevier.com/content/article/pii/S0741521420313057 doi: 10.1016/j.jvs.2020.05.049 id: cord-351431-xcqz9d3t author: Wang, Jun title: Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19 date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Cases of excessive neutrophil counts in the blood in severe coronavirus disease (COVID-19) patients have drawn significant attention. Neutrophil infiltration was also noted on the pathological findings from autopsies. It is urgent to clarify the pathogenesis of neutrophils leading to severe pneumonia in COVID-19. Methods: A retrospective analysis was performed on 55 COVID-19 patients classified as mild (n = 22), moderate (n = 25), and severe (n = 8) according to the Guidelines released by the National Health Commission of China. Trends relating leukocyte counts and lungs examined by chest CT scan were quantified by Bayesian inference. Transcriptional signatures of host immune cells of four COVID19 patients were analyzed by RNA sequencing of lung specimens and BALF. Results: Neutrophilia occurred in 6 of 8 severe patients at 7–19 days after symptom onset, coinciding with lesion progression. Increasing neutrophil counts paralleled lesion CT values (slope: 0.8 and 0.3–1.2), reflecting neutrophilia-induced lung injury in severe patients. Transcriptome analysis revealed that neutrophil activation was correlated with 17 neutrophil extracellular trap (NET)-associated genes in COVID-19 patients, which was related to innate immunity and interacted with T/NK/B cells, as supported by a protein–protein interaction network analysis. Conclusion: Excessive neutrophils and associated NETs could explain the pathogenesis of lung injury in COVID-19 pneumonia. url: https://doi.org/10.3389/fimmu.2020.02063 doi: 10.3389/fimmu.2020.02063 id: cord-333688-bykbyojs author: Wang, Junxue title: Persistent SARS-COV-2 RNA positivity in a patient for 92 days after disease onset: A case report date: 2020-08-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: RATIONALE: Recently, patients with COVID-19 who showed persistently positive SARS-CoV-2 nucleic acid test results despite resolved clinical symptoms have attracted a lot of attention. We report the case of a patient with mild symptoms of coronavirus disease (COVID-19), who achieved clinical recovery but showed persistently positive SARS-CoV-2 nucleic acid test results until Day 92 after disease onset. PATIENT CONCERNS: The patient is a 50-year-old man with mild symptoms of coronavirus disease (COVID-19). DIAGNOSES: COVID-19 pneumonia. INTERVENTIONS: The patient was quarantined for 105 days. Of these, inpatient quarantine lasted for 75 days. When the nucleic acid test results were negative for 3 consecutive days, the patient was discharged at Day 75 after disease onset. During this period, multiple samples were collected from the patient's body surface, the surrounding environment, and physical surfaces, but none of these tested positive for SARS-CoV-2. These samples included those from anal swabs, hands, inner surface of mask, cell phone, bed rails, floor around the bed, and toilet bowl surface. However, nucleic acid retest results on Day 80 and Day 92 after disease onset were positive for SARS-CoV-2 nucleic acids. OUTCOMES: The patient continued with quarantine and observation at home. After the test results on Days 101 and 105 after disease onset were negative, quarantine was terminated at last. LESSONS: Per our knowledge, this is the longest known time that a patient has tested positive for SARS-CoV-2 nucleic acids. No symptoms were observed during follow-up. During hospitalization, the SARS-CoV-2 nucleic acid positivity was not observed in samples from the body surface and surrounding environment, and no verified transmission event occurred during the quarantine at home. After undergoing clinical recovery a minority of patients with COVID-19 have shown long-term positive results for the presence of the SARS-CoV-2 nucleic acid. This has provided new understanding and research directions for coronavirus infection. Long-term follow-up and quarantine measures have been employed for such patients. Further studies are required to analyze potential infectivity in such patients and determine whether more effective antiviral drugs or regimens to enable these patients to completely clear viral infection should be researched. url: https://doi.org/10.1097/md.0000000000021865 doi: 10.1097/md.0000000000021865 id: cord-279550-7u2hksxm author: Wang, Kai title: Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection date: 2020-08-03 words: 2656.0 sentences: 190.0 pages: flesch: 56.0 cache: ./cache/cord-279550-7u2hksxm.txt txt: ./txt/cord-279550-7u2hksxm.txt summary: METHODS: Blood samples (n=173) were collected from 30 COVID-19 patients over a 3-month period after symptom onset and analyzed for SARS-CoV-2-specific NAbs, using the lentiviral pseudotype assay, coincident with the levels of IgG and proinflammatory cytokines. Thus, serological testing, especially to detect NAbs, is essential in determining the onset of the serological immune response, evaluating the potential capacity of the host body for viral clearance, and identifying donors for passive antibody therapy trials. 12, 13 However, the dynamics and roles of SARS-CoV-2-specific NAbs and their correlation with antibody responses have not been explored in COVID-19 patients more than two months after symptom onset. Furthermore, to determine if there was a statistical correlation between NAb levels and virus-specific IgG levels in COVID-19 patients, serum samples were grouped by time (weeks) after symptom onset. In summary, we determined the dynamics of NAb titers within 3 months after symptom onset in 30 SARS-CoV-2-infected patients and found a positive correlation between NAb titers and IgG antibodies. abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed vaccine or specific antiviral agents for therapy. Little is known about the longitudinal dynamics of SARS-CoV-2-specific neutralizing antibodies (NAbs) in COVID-19 patients. METHODS: Blood samples (n=173) were collected from 30 COVID-19 patients over a 3-month period after symptom onset and analyzed for SARS-CoV-2-specific NAbs, using the lentiviral pseudotype assay, coincident with the levels of IgG and proinflammatory cytokines. RESULTS: SARS-CoV-2-specific NAb titers were low for the first 7–10 d after symptom onset and increased after 2–3 weeks. The median peak time for NAbs was 33 d (IQR 24–59 d) after symptom onset. NAb titers in 93·3% (28/30) of the patients declined gradually over the 3-month study period, with a median decrease of 34·8% (IQR 19·6–42·4%). NAb titers increased over time in parallel with the rise in IgG antibody levels, correlating well at week 3 (r = 0·41, p & 0·05). The NAb titers also demonstrated a significant positive correlation with levels of plasma proinflammatory cytokines, including SCF, TRAIL, and M-CSF. CONCLUSIONS: These data provide useful information regarding dynamic changes in NAbs in COVID-19 patients during the acute and convalescent phases. url: https://doi.org/10.1093/cid/ciaa1143 doi: 10.1093/cid/ciaa1143 id: cord-350338-lcsa06gm author: Wang, Kun title: Clinical and laboratory predictors of in-hospital mortality in patients with COVID-19: a cohort study in Wuhan, China date: 2020-05-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: This study aimed to develop mortality-prediction models for patients with Coronavirus disease 2019 (COVID-19). METHODS: The training cohort were consecutive patients with COVID-19 in the First People’s Hospital of Jiangxia District in Wuhan from January 7, 2020 to February 11, 2020. We selected baseline clinical and laboratory data through the stepwise Akaike information criterion and ensemble XGBoost model to build mortality-prediction models. We then validated these models by randomly collecting COVID-19 patients in the Infection department of Union Hospital in Wuhan from January 1, 2020, to February 20, 2020. RESULTS: 296 patients with COVID-19 were enrolled in the training cohort, 19 of whom died during hospitalization and 277 were discharged from the hospital. The clinical model developed with age, history of hypertension and coronary heart disease showed AUC of 0.88 (95% CI, 0.80-0.95); threshold, -2.6551; sensitivity, 92.31%; specificity, 77.44% and negative predictive value (NPV), 99.34%. The laboratory model developed with age, high-sensitivity C-reactive protein (hsCRP), peripheral capillary oxygen saturation (SpO2), neutrophil and lymphocyte count, D-dimer, aspartate aminotransferase (AST) and glomerular filtration rate (GFR) had a significantly stronger discriminatory power than the clinical model (p=0.0157), with AUC of 0.98 (95% CI, 0.92-0.99); threshold, -2.998; sensitivity, 100.00%; specificity, 92.82% and NPV, 100.00%. In the subsequent validation cohort (N=44), the AUCs (95% CI) were 0.83 (0.68, 0.93) and 0.88 (0.75, 0.96) for clinical model and laboratory model, respectively. CONCLUSIONS: We developed two predictive models for the in-hospital mortality of patients with COVID-19 in Wuhan and validated in patients from another center. url: https://doi.org/10.1093/cid/ciaa538 doi: 10.1093/cid/ciaa538 id: cord-327961-ysatxwph author: Wang, Le title: Risk factors of 90-day rehospitalization following discharge of pediatric patients hospitalized with mycoplasma Pneumoniae pneumonia date: 2019-11-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Among pediatric patients hospitalized for Mycoplasma pneumoniae pneumonia (MPP), the risk factors for 90-day readmission after discharge is undefined. METHODS: We conducted a retrospective observational study of patients <14 years of age who were discharged with a diagnosis of MPP between January 2016 and February 2017. We collected clinical, laboratory and radiographic variables at the time of initial admission. We assessed pneumonia-related readmission within 90-day after discharge. Risk factors independently associated with rehospitalization were identified using multiple logistic regression models. RESULTS: Of the 424 MPP hospitalizations, 48 (11.3%) were readmitted within 90 days and were mainly diagnosed with pneumonia. Patients with younger age or coinfection with influenza A were more likely to be readmitted. In addition, compared with children without readmission, the readmission ones showed different clinical and laboratory characteristics at the index hospital admission. Multiple logistic regression analysis identified age (OR 0.815, 95%CI 0.706–0.940) and body temperature (OR 0.659, 95%CI 0.518–0.839) were significantly associated with lower risk of 90-day readmission. Coinfection with influenza was independently associated with a greater likelihood of 90-day readmission (OR 4.746, 95%CI 1.191–18.913). CONCLUSIONS: Readmission after MPP are common and is related to patients’ age, body temperature and influenza A coinfection during initial hospital stay, indicating potential targets could be noticed to reduce the rehospitalization after pediatric MPP. url: https://www.ncbi.nlm.nih.gov/pubmed/31718584/ doi: 10.1186/s12879-019-4616-9 id: cord-309302-n6cd2fc3 author: Wang, Li title: Clinical management of lung cancer patients during the outbreak of COVID-19 epidemic date: 2020-09-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The rapid growth of 2019 novel coronavirus (COVID-19) outbreak in Wuhan, China, at the early December 2019. COVID-19 spread all over the word just a few months. The outbreak of COVID-19 infection poses major threat to international health and economy. World Health Organization (WHO) announced that the new coronavirus was an international public health emergency on January 30, 2020. However, with the spread of COVID-19, the routine medical care of lung cancer patients was affected. Because lung cancer patients have low immunity after anti-tumor treatment, they should become the main targets for epidemic prevention. Lung cancer patients are increasingly concerned about the prevention of COVID-19. It is necessary to provide individualized medical treatment and management for lung cancer patients based on patients’ conditions and regional epidemic patterns. url: https://doi.org/10.1186/s13027-020-00322-7 doi: 10.1186/s13027-020-00322-7 id: cord-287874-wl0wlxh6 author: Wang, Ling title: Quadruple therapy for asymptomatic COVID-19 infection patients date: 2020-05-03 words: 5530.0 sentences: 267.0 pages: flesch: 45.0 cache: ./cache/cord-287874-wl0wlxh6.txt txt: ./txt/cord-287874-wl0wlxh6.txt summary: From 31 January 2020 to 10 February 2020, the patient was given quadruple therapy, including lopinavir/ritonavir tablets (400/100 mg every 12 h), arbidol tablets (0.2 g every 8 h), Lianhuaqingwen granules (a Chinese patent medicine, 6 g every 8 h) orally, and recombinant human interferon-α2b injection via aerosol (6.0 × 10 6 IU with 2 ml of sterilized water for injection every 12 h). • Quadruple therapy, which is lopinavir/ritonavir tablets, arbidol tablets, Lianhuaqingwen granules, and recombinant human interferon-α2b (IFN-α2b) injection via aerosol, is a common regimen for patients with COVID-19 in China. From 31 January 2020 to 10 February 2020, the patient was treated with four drugs, which are oral administration of lopinavir/ritonavir tablets (400/100 mg every 12 h), arbidol tablets (0.2 g every 8 h), and Lianhuaqingwen granules (a Chinese patent medicine, 6 g every 8 h) and atomization inhalation of recombinant human interferon-α2b injection (6.0 × 10 6 IU with 2 ml of sterilized water for injection every 12 h). abstract: Introduction: The novel coronavirus (COVID-19) is currently in epidemic stage. After large-scale interpersonal infection, asymptomatic patients appear. Whether asymptomatic patients are contagious or not and whether they need medication are the arguments among clinical experts. Areas covered: This paper reports a special asymptomatic couple with COVID-19, of which the male patient is an intercity bus driver but has not induced confirmed infection of his 188 passengers. The patients were treated with four combinations of lopinavir/ritonavir tablets, arbidol tablets, Lianhuaqingwen granules, and recombinant human interferon-α2b (IFN-α2b) injection via aerosol. Their clinical characteristics and medication were summarized and analyzed. Expert opinion: The two asymptomatic patients far away from Wuhan did not seem to be highly contagious. They improved obviously, after treatment with the quadruple therapy, but the effective drug is still unknown. It should be noted that lopinavir/ritonavir tablets have many drug interactions and are the most likely drugs to cause hyperlipidemia and hyperglycemia in these two patients. IFN-α2b is more effective in the early stage of virus infection. Arbidol instruction dose may not be sufficient to inhibit the novel coronavirus in vivo. The evidence-based medicine of Lianhuaqingwen granules for treating various viral infections is just based on Chinese patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32362193/ doi: 10.1080/14787210.2020.1758066 id: cord-280005-i9fp5rys author: Wang, Mengmei title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -- a Single-Center, Randomized, Controlled Clinical Trial date: 2020-09-21 words: 3185.0 sentences: 172.0 pages: flesch: 49.0 cache: ./cache/cord-280005-i9fp5rys.txt txt: ./txt/cord-280005-i9fp5rys.txt summary: title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -a Single-Center, Randomized, Controlled Clinical Trial CONCLUSIONS: In COVID-19 patients with prolonged PCR positivity, no benefit in terms of the duration of viral shedding was observed with the combined treatment of leflunomide and IFN α-2a beyond IFN α-2a alone. Based on that background, we conducted a prospective randomized, controlled, open-label trial, to evaluate the efficacy and safety of oral leflunomide to treat hospitalized COVID-19 patients with prolonged post-symptomatic viral shedding. Fifty eligible patients were randomly assigned to a combination treatment group that received leflunomide (50 mg, q12h, three consecutive times, orally; then 20 mg, once a day for 8 days; a total course of 10 days) plus nebulized IFN -2a (3 million IU each time, adding 2 ml of sterilized water, atomization inhalation twice daily for 10 days), or to a control group that received nebulized IFN -2a This was an open-label, prospective randomized, controlled trial, which was conducted at East Campus, Renmin Hospital of Wuhan University. abstract: OBJECTIVE: To evaluate the efficacy and safety of leflunomide, an approved dihydroorotate dehydrogenase inhibitor, to treat COVID-19 patients with prolonged post-symptomatic viral shedding. METHODS: We conducted a prospective, randomized, controlled, open-label trial involving hospitalized adult COVID-19 patients with prolonged PCR positivity. Patients were randomly assigned to receive either leflunomide (50 mg, q12h, three consecutive times, orally; then 20 mg, once daily for 8 days), in addition to nebulized interferon alpha 2a (IFN α-2a, 3 million IU each time, twice daily for 10 days), or nebulized IFN α-2a alone for 10 days. The primary end point was the duration of viral shedding. RESULTS: A total of 50 COVID-19 patients with prolonged PCR positivity were randomized into 2 groups; 26 were assigned to the leflunomide group, and 24 were assigned to the interferon alone group. Treatment with leflunomide was not associated with a difference from the interferon alone group in the duration of viral shedding (hazard ratio for negative RT-PCR, 0.70; 95% confidence interval, 0.391-1.256; P=0.186). In addition, the patients given leflunomide did not have a substantially shorter length of hospital stay than patients treated with interferon alone, with median (IQRs) durations of 29.0 (19.3-47.3) days and 33.0 (29.3-42.8) days, respectively, P=0.170. Two leflunomide recipients were unable to complete the full 10-day course of administration due to adverse events. CONCLUSIONS: In COVID-19 patients with prolonged PCR positivity, no benefit in terms of the duration of viral shedding was observed with the combined treatment of leflunomide and IFN α-2a beyond IFN α-2a alone. url: https://www.ncbi.nlm.nih.gov/pubmed/32955081/ doi: 10.1093/cid/ciaa1417 id: cord-355003-1o2midnh author: Wang, Min title: Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report date: 2020-09-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Globally, the coronavirus disease 2019 (COVID-19) is still spreading rapidly. At present, there are no specifically approved therapeutic agents or vaccines for its treatment. Previous studies have shown that the convalescent plasma therapy (CPT) is effective in patients with COVID-19. However, its efficacy in patients with persistently positive nucleic acid test is unknown. PATIENT CONCERNS: In this report, we present the clinical data of 5 critically ill COVID-19 patients admitted, between January 16 and February 26, 2020, in intensive care unit of Xiaogan Central Hospital. DIAGNOSIS AND INTERVENTIONS: All these patients had a persistently positive nucleic acid test and received CPT. All 5 patients had severe respiratory failure, and thus, required invasive mechanical ventilation. The median time from the onset of symptoms to initiating the CPT was 37 (Interquartile range, 34-44) days. OUTCOMES: Only 2 patients were cured and subsequently discharged, while 3 patients succumbed due to multiple organ failure. CONCLUSION: The time of initiating the CPT may be an important factor affecting its efficacy, and its therapeutic effect in the treatment of COVID-19, in the late stage, is limited. url: https://doi.org/10.1097/md.0000000000021596 doi: 10.1097/md.0000000000021596 id: cord-324529-xbrdtxnz author: Wang, Ming title: Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China date: 2020-10-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) has rapidly become a major international public health concern. This study was designed to evaluate the clinical characteristics and risk factors of COVID-19-associated liver injury. METHODS: A fraction of 657 COVID-19 patients were retrospectively analyzed. Clinical and laboratory data were derived from electronic medical records and compared between patients with or without liver injury. Multivariate logistic regression method was used to analyze the risk factors for liver injury. RESULTS: Among 657 patients, 303 (46.1%) patients had liver injury with higher rate in severe/critically ill patients [148/257 (57.6%)] than those in moderate cases [155/400 (38.8%)]. The incidence of liver injury was much higher in male [192/303 (63.4%)] than female [111/303 (36.6%)], and in severe/critical patients [148/303 (48.8%)] with percutaneous oxygen saturation ≤ 93% [89/279 (31.9%)] or peak body temperature ≥ 38.5 °C [185/301 (61.5%)] on admission. Liver injury-related inflammations included increased white blood cells, neutrophils and decreased lymphocytes. More patients with liver injury than without had increased serum IL-2R, TNFα, ferritin, hsCRP, PCT, ESR, γ-GT, and LDH. Multivariate regression analysis revealed that increasing odds of liver injury were related to male, higher serum hsCRP (≥ 10 mg/L), and neutrophil-to-lymphocyte ratio (NLR) (≥ 5). Moreover, more deceased patients (14/82 (17%)) had significantly elevated serum TBIL than discharged patients [25/532 (4.7%)]. CONCLUSION: Liver injury is a common complication in COVID-19 patients. The potential risk factors of liver injury include male, hsCRP and NLR score. A close monitor of liver function should be warned in COVID-19 patients, especially in severe/critical individuals. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12072-020-10075-5) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s12072-020-10075-5 doi: 10.1007/s12072-020-10075-5 id: cord-266214-l8pmhcd5 author: Wang, Xiaogang title: Management Strategies for Patients After CABG Surgery in the Outbreak of the COVID-19 Pandemic date: 2020-09-21 words: 2640.0 sentences: 141.0 pages: flesch: 46.0 cache: ./cache/cord-266214-l8pmhcd5.txt txt: ./txt/cord-266214-l8pmhcd5.txt summary: CONCLUSION: The management strategy here we proposed could improve the outcome of patients after CABG during the pandemic and benefit both cardiovascular patients and health-care workers. According to the data reported by the Chinese Center for Disease Control and Prevention, elderly patients with preexisting medical comorbidities are prone to severe illness and death after infection, which places the patients recovering from CABG surgery at a higher of infection. It is reported that in the over 40,000 confirmed cases, the casefatality rate of patients with CVD, diabetes, or hypertension is notably higher than average, which indicates the control of blood glucose (BG) and blood pressure (BP) playing a significant role in the prevention and outcome of COVID-19 infection for patients after CABG. Self-monitoring of COVID-19-related symptoms, including cough, fever, and dyspnea, is recommended for cardiovascular health-care workers, and a SARS-CoV-2 virus test should be considered when any kind of suspected exposure to infection occurs. abstract: BACKGROUND: The novel coronavirus 2019 pandemic (COVID-19) has quickly spread over the world and affected over 100 countries so far. Patients with pre-existing cardiovascular disease may have a higher risk of infection of COVID-19 and worse outcomes than others. To improve the outcome during the pandemic, management strategies for the patients recovering from coronary artery bypass graft (CABG) surgery need to be reconsidered. METHODS: Some precaution advices including self-protection, blood glucose and blood pressure controlling are recommended for the patients recovering from CABG during the pandemic. They are encouraged to communicate with doctors by telephone or Internet when COVID-19 related symptoms such as cough, fever and dyspnea occur. As a follow-up strategy for patients after CABG surgery, cardiac biomarkers and CTA could also be helpful to the diagnosis of COVID-19. Some medications being investigated for COVID-19 therapy may have side effects relevant to cardiovascular disease. Appropriate personal protection equipment (PPE) is necessary for cardiovascular health-care workers operating in clinical settings. RESULTS: There was zero out of over 300 follow-up patients after CABG surgery confirmed to be infected with COVID-19 from January to June 2020. No cardiovascular health-care workers were reported to be infected neither in the Second Xiangya Hospital during the pandemic. CONCLUSION: The management strategy here we proposed could improve the outcome of patients after CABG during the pandemic and benefit both cardiovascular patients and health-care workers. url: https://doi.org/10.2147/rmhp.s271133 doi: 10.2147/rmhp.s271133 id: cord-217201-lvefk7qx author: Wang, Yang title: Ontology-based annotation and analysis of COVID-19 phenotypes date: 2020-08-05 words: 2483.0 sentences: 147.0 pages: flesch: 46.0 cache: ./cache/cord-217201-lvefk7qx.txt txt: ./txt/cord-217201-lvefk7qx.txt summary: Based on the HP classification, we systematically analyze three nervous phenotypes (loss of smell, loss of taste, and headache) and four abdominal phenotypes (nausea, vomiting, abdominal pain, and diarrhea) identified in patients, and found that patients from Europe and USA turned to have higher nervous phenotypes and abdominal phenotypes than patients from Asia. First, we analyzed the group of COVID-19-related nervous system phenotypes, which includes loss of smell (anosmia), loss of taste (parageusia), and headache ( Figure 1 ). To further study the relation between different comorbidity phenotypes and disease outcomes, we survey the disease data from the literature and compared the incidences of specific comorbidity phenotypes in severe or non-severe COVID-19 patients. In severe disease patients, the incidence of diabetes or kidney failure was higher than that in non-severe patient groups (The X-axis is country/city, report date, number of cases). Based on the HP classification, we systematically analyzed 17 clinical phenotypes of COVID-19 in case reported. abstract: The epidemic of COVID-19 has caused an unpredictable and devastated disaster to the public health in different territories around the world. Common phenotypes include fever, cough, shortness of breath, and chills. With more cases investigated, other clinical phenotypes are gradually recognized, for example, loss of smell, and loss of tastes. Compared with discharged or cured patients, severe or died patients often have one or more comorbidities, such as hypertension, diabetes, and cardiovascular disease. In this study, we systematically collected and analyzed COVID-19-related clinical phenotypes from 70 articles. The commonly occurring 17 phenotypes were classified into different groups based on the Human Phenotype Ontology (HPO). Based on the HP classification, we systematically analyze three nervous phenotypes (loss of smell, loss of taste, and headache) and four abdominal phenotypes (nausea, vomiting, abdominal pain, and diarrhea) identified in patients, and found that patients from Europe and USA turned to have higher nervous phenotypes and abdominal phenotypes than patients from Asia. A total of 23 comorbidities were found to commonly exist among COVID-19 patients. Patients with these comorbidities such as diabetes and kidney failure had worse outcomes compared with those without these comorbidities. url: https://arxiv.org/pdf/2008.02241v1.pdf doi: nan id: cord-258113-mnou31j3 author: Wang, Yaping title: Clinical Characteristics of Patients Infected With the Novel 2019 Coronavirus (SARS-Cov-2) in Guangzhou, China date: 2020-05-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The clinical manifestations and factors associated with the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections outside of Wuhan are not clearly understood. METHODS: All laboratory-confirmed cases with SARS-Cov-2 infection who were hospitalized and monitored in Guangzhou Eighth People’s Hospital were recruited from January 20 to February 10. RESULTS: A total of 275 patients were included in this study. The median patient age was 49 years, and 63.6% had exposure to Wuhan. The median virus incubation period was 6 days. Fever (70.5%) and dry cough (56.0%) were the most common symptoms. A decreased albumin level was found in 51.3% of patients, lymphopenia in 33.5%, and pneumonia based on chest computed tomography in 86%. Approximately 16% of patients (n = 45) had severe disease, and there were no deaths. Compared with patients with nonsevere disease, those with severe disease were older, had a higher frequency of coexisting conditions and pneumonia, and had a shorter incubation period (all P < .05). There were no differences between patients who likely contacted the virus in Wuhan and those who had no exposure to Wuhan. Multivariate logistic regression analysis indicated that older age, male sex, and decreased albumin level were independently associated with disease severity. CONCLUSIONS: Most of the patients infected with SARS-CoV-2 in Guangzhou, China are not severe cases and patients with older age, male, and decreased albumin level were more likely to develop into severe ones. url: https://doi.org/10.1093/ofid/ofaa187 doi: 10.1093/ofid/ofaa187 id: cord-346015-bzeqs5oh author: Wang, Yeming title: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on pathogenic animal and human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, and inhibits Middle East respiratory syndrome coronavirus, SARS-CoV-1, and SARS-CoV-2 replication in animal models. METHODS: We did a randomised, double-blind, placebo-controlled, multicentre trial at ten hospitals in Hubei, China. Eligible patients were adults (aged ≥18 years) admitted to hospital with laboratory-confirmed SARS-CoV-2 infection, with an interval from symptom onset to enrolment of 12 days or less, oxygen saturation of 94% or less on room air or a ratio of arterial oxygen partial pressure to fractional inspired oxygen of 300 mm Hg or less, and radiologically confirmed pneumonia. Patients were randomly assigned in a 2:1 ratio to intravenous remdesivir (200 mg on day 1 followed by 100 mg on days 2–10 in single daily infusions) or the same volume of placebo infusions for 10 days. Patients were permitted concomitant use of lopinavir–ritonavir, interferons, and corticosteroids. The primary endpoint was time to clinical improvement up to day 28, defined as the time (in days) from randomisation to the point of a decline of two levels on a six-point ordinal scale of clinical status (from 1=discharged to 6=death) or discharged alive from hospital, whichever came first. Primary analysis was done in the intention-to-treat (ITT) population and safety analysis was done in all patients who started their assigned treatment. This trial is registered with ClinicalTrials.gov, NCT04257656. FINDINGS: Between Feb 6, 2020, and March 12, 2020, 237 patients were enrolled and randomly assigned to a treatment group (158 to remdesivir and 79 to placebo); one patient in the placebo group who withdrew after randomisation was not included in the ITT population. Remdesivir use was not associated with a difference in time to clinical improvement (hazard ratio 1·23 [95% CI 0·87–1·75]). Although not statistically significant, patients receiving remdesivir had a numerically faster time to clinical improvement than those receiving placebo among patients with symptom duration of 10 days or less (hazard ratio 1·52 [0·95–2·43]). Adverse events were reported in 102 (66%) of 155 remdesivir recipients versus 50 (64%) of 78 placebo recipients. Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early. INTERPRETATION: In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits. However, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies. FUNDING: Chinese Academy of Medical Sciences Emergency Project of COVID-19, National Key Research and Development Program of China, the Beijing Science and Technology Project. url: https://api.elsevier.com/content/article/pii/S0140673620310229 doi: 10.1016/s0140-6736(20)31022-9 id: cord-316137-6zdxfv8v author: Wang, Yuanyuan title: Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching date: 2020-11-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: : Chinese herbal medicine (CHM) has been used for severe illness caused by coronavirus disease 2019 (COVID-19), but its treatment effects and safety are unclear. PURPOSE: : This study reviews the effect and safety of CHM granules in the treatment of patients with severe COVID-19. METHODS: : We conducted a single-center, retrospective study on patients with severe COVID-19 in a designated hospital in Wuhan from January 15, 2020 to March 30, 2020. The propensity score matching (PSM) was used to assess the effect and safety of the treatment using CHM granules. The ratio of patients who received treatment with CHM granules combined with usual care and those who received usual care alone was 1:1. The primary outcome was the time to clinical improvement within 28 days, defined as the time taken for the patients’ health to show improvement by decline of two categories (from the baseline) on a modified six-category ordinal scale, or to be discharged from the hospital before Day 28. RESULTS: : Using PSM, 43 patients (45% male) aged 65.6 (57–70) years from each group were exactly matched. No significant difference was observed in clinical improvement of patients treated with CHM granules compared with those who received usual (P = 0.851). However, the use of CHM granules reduced the 28-day mortality (P = 0.049) and shortened the duration of fever (4 days vs. 7 days, P = 0.002). The differences in the duration of cough and dyspnea and the difference in lung lesion ratio on computerized tomography scans were not significant. Commonly, patients in the CHM group had an increased D-dimer level (P = 0.036). CONCLUSION: : For patients with severe COVID-19, CHM granules, combined with usual care, showed no improvement beyond usual care alone. However, the use of CHM granules reduced the 28-day mortality rate and the time to fever alleviation. Nevertheless, CHM granules may be associated with high risk of fibrinolysis. url: https://api.elsevier.com/content/article/pii/S094471132030235X doi: 10.1016/j.phymed.2020.153404 id: cord-299082-s8bm40vy author: Wang, Yueying title: Cardiac arrhythmias in patients with COVID‐19 date: 2020-07-26 words: 3714.0 sentences: 247.0 pages: flesch: 40.0 cache: ./cache/cord-299082-s8bm40vy.txt txt: ./txt/cord-299082-s8bm40vy.txt summary: 5, 6, 9, 10, [12] [13] [14] [15] Several investigators have reported cardiac function and structural abnormalities in patients with SARS-CoV-2 infection, including acute heart failure (HF), 3,10,16 takotsubo syndrome, 17 ,18 viral myocarditis, 19 and acute myocardial infarction. In addition to exacerbating the previous cardiomyopathy and conduction disorders, inducing arrhythmia events, SARS-CoV-2 may also induce electrophysiological abnormalities in patients with no previous history of heart disease under a variety of mechanisms. Clinical features and mechanism of heart injury in patients suffered from severe acute respiratory syndrome. Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19) abstract: The emergence of coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has become a major global public health concern. Although SARS‐CoV‐2 causes primarily respiratory problems, concurrent cardiac injury cannot be ignored since it may be an independent predictor for adverse outcomes. Cardiac arrhythmias are often observed in patients with COVID‐19, especially in severe cases, and more likely contribute to the high risk of adverse outcomes. Arrhythmias should be regarded as one of the main complications of COVID‐19. Mechanistically, a number of ion channels can be adversely affected in COVID‐19, leading to alterations in cardiac conduction and/or repolarization properties, as well as calcium handling, which can predispose to cardiac arrhythmogenesis. In addition, several antimicrobials that are currently used as potential therapeutic agents for COVID‐19, such as chloroquine, hydroxychloroquine and azithromycin, have uncertain benefit, and yet may induce electrocardiographic QT prolongation with potential ventricular pro‐arrhythmic effects. Continuous electrocardiogram monitoring, accurate and prompt recognition of arrhythmias are important. The present review focuses on cardiac arrhythmias in patients with COVID‐19, its underlying mechanisms, and proposed preventive and therapeutic strategies. url: https://www.ncbi.nlm.nih.gov/pubmed/33024460/ doi: 10.1002/joa3.12405 id: cord-349740-xed4aybr author: Wang, Yulong title: Recommendations of protective measures for orthopedic surgeons during COVID-19 pandemic date: 2020-06-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: It was the primary purpose of the present systematic review to identify the optimal protection measures during COVID-19 pandemic and provide guidance of protective measures for orthopedic surgeons. The secondary purpose was to report the protection experience of an orthopedic trauma center in Wuhan, China during the pandemic. METHODS: A systematic search of the PubMed, Cochrane, Web of Science, Google Scholar was performed for studies about COVID-19, fracture, trauma, orthopedic, healthcare workers, protection, telemedicine. The appropriate protective measures for orthopedic surgeons and patients were reviewed (on-site first aid, emergency room, operating room, isolation wards, general ward, etc.) during the entire diagnosis and treatment process of traumatic patients. RESULTS: Eighteen studies were included, and most studies (13/18) emphasized that orthopedic surgeons should pay attention to prevent cross-infection. Only four studies have reported in detail how orthopedic surgeons should be protected during surgery in the operating room. No detailed studies on multidisciplinary cooperation, strict protection, protection training, indications of emergency surgery, first aid on-site and protection in orthopedic wards were found. CONCLUSION: Strict protection at every step in the patient pathway is important to reduce the risk of cross-infection. Lessons learnt from our experience provide some recommendations of protective measures during the entire diagnosis and treatment process of traumatic patients and help others to manage orthopedic patients with COVID-19, to reduce the risk of cross-infection between patients and to protect healthcare workers during work. LEVEL OF EVIDENCE: IV. url: https://www.ncbi.nlm.nih.gov/pubmed/32524164/ doi: 10.1007/s00167-020-06092-4 id: cord-343566-epvswt7f author: Wang, Zhao-Hua title: Critically Ill Patients with Coronavirus Disease 2019 in a Designated ICU: Clinical Features and Predictors for Mortality date: 2020-07-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a worldwide pandemic outbreak with a high mortality. Prognostic factors of critically ill patients with COVID-19 have not been fully elucidated yet. METHODS: In the present study, 59 patients with COVID-19 from the intensive care unit of the Caidian Branch of Tongji Hospital were enrolled. Epidemiological, demographic, clinical, laboratory, radiological, treatment data, and clinical outcomes were collected. Prognostic factors were statistically defined. RESULTS: Of the 59 patients studied (67.4±11.3 years), 38 patients were male, 51 had underlying diseases, and 41 patients died during admission. Compared with the survivors, the deceased patients were of older age, had more smoking history, severer fatigue, and diarrhea, a higher incidence of multiple organ injuries, more deteriorative lymphopenia and thrombocytopenia, remarkably impaired cellular immune response, and strengthened cytokine release. Age higher than 70 (OR=2.76, 95% CI=1.45–5.23), arrhythmia (OR=4.76, 95% CI=1.59–14.25), and a Sequential Organ Failure Assessment (SOFA) score above 4 (OR=5.16, 95% CI=1.29–20.55) were identified as risk factors for mortality of patients. CONCLUSION: Critically ill COVID-19 patients aged higher than 70, arrhythmia, or a SOFA score above 4 have a high risk of mortality, and need prior medical intervention. url: https://www.ncbi.nlm.nih.gov/pubmed/32765138/ doi: 10.2147/rmhp.s263095 id: cord-272553-bcmta2he author: Wang, Zhiqiang title: Clinical characteristics and laboratory results of pregnant women with COVID‐19 in Wuhan, China date: 2020-07-03 words: 1664.0 sentences: 103.0 pages: flesch: 47.0 cache: ./cache/cord-272553-bcmta2he.txt txt: ./txt/cord-272553-bcmta2he.txt summary: METHODS: A retrospective study to review and compare clinical data including electronic medical records and laboratory tests from pregnant and nonpregnant patients admitted the Central Hospital of Wuhan, China from December 8, 2019 to April 1, 2020. Laboratory test results showed that levels of inflammation markers such as white blood cell count, neutrophil count and percentage, C‐reactive protein, procalcitonin, and D‐dimer were significantly higher in pregnant women, whereas mean lymphocyte percentage was significantly lower compared with nonpregnant women. Therefore, the aim of the present study was to investigate and report the clinical characteristics and laboratory test results of pregnant women with COVID-19 to strengthen the knowledge base. 6 The treatment strategy in the present study folThe clinical characteristics of pregnant patients extracted from medical records were gestational age; time interval between symptom onset and admission; time interval between hospitalization and delivery; delivery mode; length of hospital stay; initial symptoms (fever, cough, abdominal pain, blood-tinged mucus, ruptured membranes at term, chest tightness, asthma, fatigue, poor appetite, headache, nausea, and vomiting); and maternal comorbidities (gestational diabetes, gestational hypertension, intrahepatic cholestasis of pregnancy, premature rupture of membranes, and obesity). abstract: OBJECTIVE: To evaluate the clinical characteristics and laboratory test results in pregnant women with coronavirus disease 2019 (COVID‐19). METHODS: A retrospective study to review and compare clinical data including electronic medical records and laboratory tests from pregnant and nonpregnant patients admitted the Central Hospital of Wuhan, China from December 8, 2019 to April 1, 2020. RESULTS: A total of 72 women (30 pregnant and 42 nonpregnant) with COVID‐19 were included. No patients developed severe pneumonia during the study. Compared with the nonpregnant group, pregnant patients were admitted to hospital earlier (0.25 vs 11.00 days; P<0.001), presented milder symptoms, had a higher rate of asymptomatic infection (26.7% vs 0%), and shorter length of hospital stay (14.5 vs 17.0 days; P<0.01). Laboratory test results showed that levels of inflammation markers such as white blood cell count, neutrophil count and percentage, C‐reactive protein, procalcitonin, and D‐dimer were significantly higher in pregnant women, whereas mean lymphocyte percentage was significantly lower compared with nonpregnant women. CONCLUSION: In some respects, the clinical characteristics and laboratory test results of COVID‐19 in pregnant patients seems to be distinctive from their nonpregnant counterparts. Appropriate advice and positive treatment might be critical to the prognosis when dealing with these pregnant patients. Pregnant patients with COVID‐19 had their own positive clinical characteristics and special laboratory test results. Responsive medical advice and active treatment for those patients are critical to recovery. url: https://doi.org/10.1002/ijgo.13265 doi: 10.1002/ijgo.13265 id: cord-259073-dixskemz author: Ward, Christine F. title: Altered Mental Status as a Novel Initial Clinical Presentation for COVID-19 Infection in the Elderly date: 2020-05-15 words: 2126.0 sentences: 124.0 pages: flesch: 47.0 cache: ./cache/cord-259073-dixskemz.txt txt: ./txt/cord-259073-dixskemz.txt summary: The elderly are the most vulnerable to significant adverse complications from COVID 19 and AMS should be considered as a possible sign of infection to initiate treatment early in the course of the disease, perhaps before respiratory symptoms are apparent. In this report, we present four patients diagnosed with COVID-19 who initially presented with altered mental status without fever or cough or respiratory distress. Each of the four patients developed AMS without fever or respiratory symptoms and were transferred to the local emergency department and were tested for the COVID-19 virus as part of their medical work up. Recognizing the COVID-19 infection early is especially important in the frail elderly, particularly for individuals in communal living facilities where isolating these patients can help limit the spread of the virus, There is evidence from previous viral epidemics of associated neuropsychiatric symptoms. abstract: The coronavirus disease of 2019 or COVID-19 was first identified in Hubei Province in China in November of 2019 and quickly spread to become a global pandemic. The virus, SARS-Coronavirus-2 (2-SARS-CoV-2), is particularly virulent in the elderly who can develop symptoms and become mortally ill within days of contracting the virus. The virus is easily transmitted by droplets (e.g., sneezing, coughing) and communal living settings such as personal care homes can be vulnerable to the spread of the virus. Identifying patients early in the disease process is important to providing appropriate medical interventions. To date, most of the medical literature, including Center for Disease Control guidelines, has relied on three necessary symptoms in making the diagnosis of COVID-19: fever, cough and shortness of breath. We present four cases of elderly patients who developed altered mental status as their presenting symptom without associated fever or respiratory symptoms. url: https://www.ncbi.nlm.nih.gov/pubmed/32425470/ doi: 10.1016/j.jagp.2020.05.013 id: cord-349678-79zlgjqi author: Warrior, Krishnan title: Acute Limb Ischemia Due to Arterial Thrombosis Associated With Coronavirus Disease 2019 date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To describe a case of acute limb ischemia caused by arterial thrombosis due to coronavirus disease 2019. DESIGN: Clinical observation of a patient. SETTING: Academic medical center. PATIENT: A 59-year-old female with history of hypertension, hyperlipidemia, and prior smoking. INTERVENTION: Clinical observation and data extraction from electronic medical records. MEASUREMENTS AND MAIN RESULTS: We report a case of peripheral arterial thrombosis associated with coronavirus disease 2019, resulting in acute limb ischemia of the right lower extremity. This event was heralded by a sudden and significant elevation in d-dimer levels. At the time of surgery, a long, gelatinous clot was retrieved from the right popliteal artery. Perioperatively, she continued to have absent pedal Doppler signals and after multiple embolectomy attempts, required distal arterial cut down with removal of additional thrombi and resultant improvement of distal arterial flow. CONCLUSIONS: This case demonstrates the importance of regularly checking d-dimer levels and vigilant monitoring for arterial thrombotic events, as they can rapidly become catastrophic. url: https://doi.org/10.1097/cce.0000000000000140 doi: 10.1097/cce.0000000000000140 id: cord-272976-pb2bjpop author: Washington, Lacey title: ACR Appropriateness Criteria(®) on Acute Respiratory Illness date: 2009-10-01 words: 2856.0 sentences: 131.0 pages: flesch: 33.0 cache: ./cache/cord-272976-pb2bjpop.txt txt: ./txt/cord-272976-pb2bjpop.txt summary: In a patient with acute respiratory illness (cough, sputum production, chest pain, and/or dyspnea), the need for chest imaging depends on the severity of illness, age of the patient, clinical history, physical and laboratory findings, and other risk factors. Chest radiographs seem warranted when one or more of the following are present: age ≥ 40; dementia; a positive physical examination; hemoptysis; associated abnormalities (leukocytosis, hypoxemia); or other risk factors, including coronary artery disease, congestive heart failure, or drug-induced acute respiratory failure. computed tomography (CT), depends on many factors, including the severity of the illness; the age of the patient; the presence of fever, leukocytosis, or hypoxemia; clinical history; the presence of other risk factors; and the results of physical examination. On the basis of these studies, chest radiography seems warranted in ARI when Ն1 of the following is present: age Ͼ40 years; dementia; positive results on physical examination; hemoptysis; associated abnormalities (leukocytosis, hypoxemia); or other risk factors, including coronary artery disease, congestive heart failure, or druginduced acute respiratory failure. abstract: In a patient with acute respiratory illness (cough, sputum production, chest pain, and/or dyspnea), the need for chest imaging depends on the severity of illness, age of the patient, clinical history, physical and laboratory findings, and other risk factors. Chest radiographs seem warranted when one or more of the following are present: age ≥ 40; dementia; a positive physical examination; hemoptysis; associated abnormalities (leukocytosis, hypoxemia); or other risk factors, including coronary artery disease, congestive heart failure, or drug-induced acute respiratory failure. Chest CT may be warranted in complicated cases of severe pneumonia and in febrile neutropenic patients with normal or nonspecific chest radiographic findings. Literature on the indications and usefulness of radiologic studies for acute respiratory illness in different clinical settings is reviewed. url: https://www.sciencedirect.com/science/article/pii/S1546144009003184 doi: 10.1016/j.jacr.2009.06.022 id: cord-017392-ja9b5vy9 author: Waterer, G. W. title: Adjunctive and Supportive Measures for Community-Acquired Pneumonia date: 2010-05-20 words: 4461.0 sentences: 232.0 pages: flesch: 35.0 cache: ./cache/cord-017392-ja9b5vy9.txt txt: ./txt/cord-017392-ja9b5vy9.txt summary: Randomized, controlled trials have shown corticosteroids reduce mortality in AIDS patients with Pneumocystis carinii pneumonia and significant hypoxia, if instituted at or prior to the onset of anti-pneumocystis therapy [8, 9] . Anecdotally, corticosteroids are frequently used in the setting of severe fungal pneumonia, particularly due to Histoplasmosis [11, 12] , and a small controlled trial of 55 patients supported their use in miliary tuberculosis [13] . Following the success of pre-antibiotic corticosteroids in children with meningitis [14] , Marik and colleagues [15] studied the effect of a single dose of hydrocortisone (10 mg/kg) 30 min prior to antibiotic therapy in a small randomized placebo controlled trial of 30 adult patients with severe CAP (SCAP). Once respiratory failure has ensued, supportive measures such as patient positioning and differential lung ventilation can improve oxygenation at no additional risk in some patients, particularly those with severe unilateral pneumonia. abstract: The widespread introduction of penicillin in the 1940s resulted in a substantial reduction in mortality from community-acquired pneumonia (CAP). However, despite significant advances in medical science, only a small improvement has occurred since, particularly in patients with bacteremic pneumococcal pneumonia [1, 2]. Even modern intensive care has only made a small difference to the mortality in patients with severe pneumonia [3, 4]. While the aging population, increased number of patients with severe co-morbid illnesses, and the human immunodeficiency virus (HIV) epidemic have certainly contributed to the persistently high mortality rate [2, 5, 6], apparently healthy, immunocompetent patients continue to die from CAP. Disturbingly, a recent British Thoracic Society study concluded that no available therapy could substantially reduce the mortality rate from severe CAP in young adults [7]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121945/ doi: 10.1007/978-3-540-34406-3_38 id: cord-296607-h2zwlyz7 author: Watson, Ryan A. title: Anti-coagulant and anti-platelet therapy in the COVID-19 patient: a best practices quality initiative across a large health system date: 2020-06-09 words: 7738.0 sentences: 370.0 pages: flesch: 35.0 cache: ./cache/cord-296607-h2zwlyz7.txt txt: ./txt/cord-296607-h2zwlyz7.txt summary: What is clear is that patients appear to be at higher risk for thrombotic disease states including acute coronary syndrome (ACS), venous thromboembolism (VTE) such as deep vein thrombosis (DVT) or pulmonary embolism (PE), or stroke. In most scenarios, direct oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) are recommended over warfarin due to large randomized controlled trials showing noninferiority or superiority for stroke reduction and superiority for bleeding risk in patients with non-valvular atrial fibrillation [29] [30] [31] [32] . The use of UFH or LMWH may be considered in patients with high potential stroke risk and new onset atrial fibrillation; however, heparin drips require constant monitoring and titration of dosing during hospitalization leading to increased nursing exposure to potential COVID-19 patients. A French cohort of ICU patients on pharmacologic prophylaxis found a high prevalence of thrombotic complications including PE, stroke, circuit clotting of continuous renal replacement therapy or extracorporeal membrane oxygenation (ECMO) with minimal bleeding risk suggesting the need for higher doses of prophylactic anticoagulation in this patient population [70] . abstract: The coronavirus disease 2019 (COVID-19) pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged health-care systems and physicians worldwide to attempt to provide the best care to their patients with an evolving understanding of this unique pathogen. This disease and its worldwide impact have sparked tremendous interest in the epidemiology, pathogenesis, and clinical consequences of COVID-19. This accumulating body of evidence has centered around case series and often empiric therapies as controlled trials are just getting underway. What is clear is that patients appear to be at higher risk for thrombotic disease states including acute coronary syndrome (ACS), venous thromboembolism (VTE) such as deep vein thrombosis (DVT) or pulmonary embolism (PE), or stroke. Patients with underlying cardiovascular disease are also at higher risk for morbidity and mortality if infected. These patients are commonly treated with anticoagulation and/or antiplatelet medications and less commonly thrombolysis during hospitalization, potentially with great benefit but the management of these medications can be difficult in potentially critically ill patients. In an effort to align practice patterns across a large health system (Jefferson Health 2,622 staffed inpatient beds and 319 intensive care unit (ICU) beds across 14 facilities), a task force was assembled to address the utilization of anti-thrombotic and anti-platelet therapy in COVID-19 positive or suspected patients. The task force incorporated experts in Cardiology, Vascular Medicine, Hematology, Vascular Surgery, Pharmacy, and Vascular Neurology. Current guidelines, consensus documents, and policy documents from specialty organizations were used to formulate health system recommendations. OBJECTIVE: Our goal is to provide guidance to the utilization of antithrombotic and antiplatelet therapies in patients with known or suspected COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32429774/ doi: 10.1080/21548331.2020.1772639 id: cord-008596-zhk82cor author: Watts, Clark title: Erosion of physician autonomy and public respect for the profession() date: 2008-07-09 words: 3900.0 sentences: 193.0 pages: flesch: 52.0 cache: ./cache/cord-008596-zhk82cor.txt txt: ./txt/cord-008596-zhk82cor.txt summary: The questions are "what happened?" and "why review this topic now?" In inverse order, I believe after the present presidential campaign, we will see major efforts to revise the structure of the US health care system, and the changes advocated will have significant impacts on physicians and the way they practice [4] . Belatedly, physicians began organizing their practices around the group model to overcome these concerns; belatedly, because the managed care model they were fighting began to lose acceptance by the public as it did not hold down costs, and its proactive policies regarding physician decision making were offensive to patients [15] . These changes in the US health care system, which have restricted physician autonomy, have also adversely affected the public''s respect for the medical profession for one major reason. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133191/ doi: 10.1016/j.surneu.2008.05.005 id: cord-321543-qdmvn44h author: Webb, J. B. title: Computational Simulation to Assess Patient Safety of Uncompensated COVID-19 Two-patient Ventilator Sharing Using the Pulse Physiology Engine date: 2020-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: The COVID-19 pandemic is stretching medical resources internationally, including creating ventilator shortages that complicate clinical and ethical situations. The possibility of needing to ventilate multiple patients with a single ventilator raises patient health and safety concerns. This simulation study explores patient compatibility and ventilator settings during multi-patient ventilation without the use of flow compensating resistances. Methods: A whole-body computational physiology model was used to simulate each patient on a ventilator. The primary model of a single patient with a dedicated ventilator was augmented to model two patients sharing a single ventilator. A range of ventilator settings and patient characteristics were simulated for paired patients. In addition to mechanical ventilation parameters, the full physiological simulation provides estimates of additional values for oxyhemoglobin saturation, arterial oxygen tension, and other patient parameters. Findings: These simulations show patient outcome during multi-patient ventilation is most closely correlated to lung compliance, oxygenation index, oxygen saturation index, and endtidal carbon dioxide of individual patients. The simulated patient outcome metrics were satisfactory when the lung compliance difference between two patients was less than 12 cmH2O/mL, and the oxygen saturation index difference was less than 2 mmHg. Interpretation: In resource-limited regions of the world, the COVID-19 pandemic will result in equipment shortages. While single-patient ventilation is preferable, if unavailable, these simulations provide a conceptual framework for clinical patient selection guidelines if ventilator sharing is the only available alternative. url: http://medrxiv.org/cgi/content/short/2020.05.19.20107201v1?rss=1 doi: 10.1101/2020.05.19.20107201 id: cord-309421-725u6dau author: Wechsler, Michael E. title: SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma date: 2020-10-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Many patients with severe asthma continue to experience asthma symptoms and exacerbations despite standard-of-care treatment. A substantial proportion of these patients require long-term treatment with oral corticosteroids (OCS), often at high doses, which are associated with considerable multiorgan adverse effects, including metabolic disorders, osteoporosis and adrenal insufficiency. Tezepelumab is a human monoclonal antibody that blocks the activity of the epithelial cytokine thymic stromal lymphopoietin. In the PATHWAY phase 2b study (NCT02054130), tezepelumab significantly reduced exacerbations by up to 71% in adults with severe, uncontrolled asthma. Several ongoing phase 3 trials (SOURCE, NCT03406078; NAVIGATOR, NCT03347279; DESTINATION, NCT03706079) are assessing the efficacy and safety of tezepelumab in patients with severe, uncontrolled asthma. Here, we describe the design and objectives of SOURCE, a phase 3 OCS-sparing study. METHODS: SOURCE is an ongoing phase 3, multicentre, randomized, double-blind, placebo-controlled study to evaluate the effect of tezepelumab 210 mg administered subcutaneously every 4 weeks on OCS dose reduction in adults with OCS-dependent asthma. The study comprises a 2-week screening and enrolment period, followed by an OCS optimization phase of up to 8 weeks and a 48-week treatment period, which consists of a 4-week induction phase, followed by a 36-week OCS reduction phase and an 8-week maintenance phase. The primary objective is to assess the effect of tezepelumab compared with placebo in reducing the prescribed OCS maintenance dose. The key secondary objective is to assess the effect of tezepelumab on asthma exacerbation rates. Other secondary objectives include the proportion of patients with a reduction in OCS dose (100% or 50% reduction or those receiving < 5 mg) and the effect of tezepelumab on lung function and patient-reported outcomes. CONCLUSIONS: SOURCE is evaluating the OCS-sparing potential of tezepelumab in patients with OCS-dependent asthma. SOURCE also aims to demonstrate that treatment with tezepelumab in patients with severe asthma is associated with reductions in exacerbation rates and improvements in lung function, asthma control and health-related quality of life, while reducing OCS dose. TRIAL REGISTRATION: NCT03406078 (ClinicalTrials.gov). Registered 23 January 2018. https://clinicaltrials.gov/ct2/show/NCT03406078 url: https://doi.org/10.1186/s12931-020-01503-z doi: 10.1186/s12931-020-01503-z id: cord-335338-wzxjn5ip author: Wei, Lan title: Pathology of the thyroid in severe acute respiratory syndrome() date: 2006-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The severe acute respiratory syndrome (SARS) epidemic started in November 2002 and spread worldwide. The pathological changes in several human organs of patients with SARS have been extensively described. However, to date, little has been reported about the effects of this infection on the thyroid gland. Femoral head necrosis and low serum triiodothyronine and thyroxine levels, commonly found in patients with SARS, raise the possibility of thyroid dysfunction. We have undertaken this study to evaluate for any potential injury to the thyroid gland caused by SARS on tissue samples obtained from 5 SARS autopsies. The terminal deoxynucleotidyl transferase-mediated dUPT nick end–labeling assay was performed to identify apoptotic cells. The follicular epithelium was found to be damaged with large numbers of cells exfoliated into the follicle. The terminal deoxynucleotidyl transferase-mediated dUPT nick end–labeling assay demonstrated many cells undergoing apoptosis. Follicular architecture was altered and showed distortion, dilatation, and collapse. No distinct calcitonin-positive cells were detectable in the SARS thyroids. In conclusion, both parafollicular and follicular cells were injured. This may provide an explanation both for low serum triiodothyronine and thyroxine levels and the osteonecrosis of the femoral head associated with patients with SARS. Apoptosis may play a role in the pathogenesis of SARS associated coronavirus infection in the thyroid gland. url: https://www.sciencedirect.com/science/article/pii/S0046817706003807 doi: 10.1016/j.humpath.2006.06.011 id: cord-262796-syu4wbpi author: Wei, Xiao-Shan title: Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19 date: 2020-04-18 words: 2863.0 sentences: 174.0 pages: flesch: 57.0 cache: ./cache/cord-262796-syu4wbpi.txt txt: ./txt/cord-262796-syu4wbpi.txt summary: Abstract Background & Aims We compared clinical, laboratory, radiological, and outcome features of patients with SARS-CoV-2 infection (COVID-19) with pneumonia, with vs without diarrhea. Methods We performed a retrospective, single-center analysis of 84 patients with SARS-CoV-2 pneumonia in Wuhan Union Hospital, China, from January 19 through February 7, 2020. Of 76 patients with a negative result from their latest throat swab test during hospitalization, a significantly higher proportion of patients with diarrhea had a positive result from the retest for SARS-CoV-2 in stool (45%) than patients without diarrhea (20%) (P=.039). On admission to hospital, all confirmed COVID patients were tested for SARS-CoV-2 RNA from stool samples. Of 76 COVID-19 patients who had a negative result from their latest throat swab test during hospitalization, a significantly higher proportion of patients with diarrhea had a positive result from the retest for SARS-CoV-2 in stool (45%) than patients without diarrhea (20%) (P=.039) ( Table 5) . abstract: Abstract Background & Aims We compared clinical, laboratory, radiological, and outcome features of patients with SARS-CoV-2 infection (COVID-19) with pneumonia, with vs without diarrhea. Methods We performed a retrospective, single-center analysis of 84 patients with SARS-CoV-2 pneumonia in Wuhan Union Hospital, China, from January 19 through February 7, 2020. Cases were confirmed by real-time reverse-transcriptase PCR of nasal and pharyngeal swab specimens for SARS-CoV-2 RNA. Blood samples were analyzed for white blood cell count, lymphocyte count, alanine aminotransferase, creatine kinase, lactate dehydrogenase, D-dimer, C-reactive protein, and in some cases, immunoglobulins, complement, lymphocyte subsets, and cytokines. Virus RNA was detected in stool samples by real-time PCR. Results Of the 84 patients with SARS-CoV-2 pneumonia, 26 (31%) had diarrhea. The duration of fever and dyspnea in patients with diarrhea was significantly longer than those without diarrhea (all P<.05). Stool samples from a higher proportion of patients with diarrhea tested positive for virus RNA (69%) than from patients without diarrhea (17%) (P<.001). As of February 19, a lower proportion of patients with diarrhea had a negative result from the latest throat swab for SARS-CoV-2 (77%) than patients without diarrhea (97%) (P=.010), during these patients’ hospitalization. Of 76 patients with a negative result from their latest throat swab test during hospitalization, a significantly higher proportion of patients with diarrhea had a positive result from the retest for SARS-CoV-2 in stool (45%) than patients without diarrhea (20%) (P=.039). Conclusions At a single center in Wuhan, China, 31% of patients with SARS-CoV-2 pneumonia had diarrhea. A significantly higher proportion of patients with diarrhea have virus RNA in stool than patients without diarrhea. Elimination of SARS-CoV-2 from stool takes longer than elimination from the nose and throat. url: https://api.elsevier.com/content/article/pii/S1542356520305267 doi: 10.1016/j.cgh.2020.04.030 id: cord-138439-wvynetna author: Wei, Xiyi title: Sex Differences in Severity and Mortality Among Patients With COVID-19: Evidence from Pooled Literature Analysis and Insights from Integrated Bioinformatic Analysis date: 2020-03-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective: To conduct a meta-analysis of current studies that examined sex differences in severity and mortality in patients with COVID-19, and identify potential mechanisms underpinning these differences. Methods: We performed a systematic review to collate data from observational studies examining associations of sex differences with clinical outcomes of COVID-19. PubMed, Web of Science and four preprint servers were searched for relevant studies. Data were extracted and analyzed using meta-analysis where possible, with summary data presented otherwise. Publicly available bulk RNA sequencing (RNA-seq), single-cell RNA sequencing (scRNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq) data were analyzed to explore the potential mechanisms underlying the observed association. Results: 39 studies met inclusion criteria, representing 77932 patients, of which 41510 (53.3%) were males. Men were at a markedly increased risk of developing severe cases compared with women. Furthermore, the pooled odds ratio (OR) of mortality for male group compared with the female group indicated significant higher mortality rate for male. Data from scRNA-seq suggest that men have a higher amount of ACE2-expressing pulmonary alveolar type II cells than women. Sex-based immunological differences exist. The expression of androgen receptor (AR) is positively correlated with ACE2, and there is evidence that AR may directly regulate the expression of ACE2. Conclusions: This meta-analysis detected an increased severity and mortality rate in the male populations with COVID-19, which might be attributable to the sex-based differences in cellular compositions and immunological microenvironments of the lung. The host cell receptor ACE2 is likely regulated by AR signaling pathway, which is identified as a potential target for prevention and treatment of SARS-Cov-2 infections in men. url: https://arxiv.org/pdf/2003.13547v1.pdf doi: nan id: cord-261470-sqxdwu6j author: Weichmann, Franziska title: Projected supportive effects of Pycnogenol® in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection date: 2020-10-09 words: 5918.0 sentences: 308.0 pages: flesch: 38.0 cache: ./cache/cord-261470-sqxdwu6j.txt txt: ./txt/cord-261470-sqxdwu6j.txt summary: Two London based hospitals also found increasing numbers of patients with Kawasaki-like symptoms in communities with high rates of COVID 19, which was provisionally called pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) [68] [70] . Another double-blind, placebo-controlled study reported similar effects when supplementing type II diabetes and hypertensive patients, taking ACE inhibitor medication together with 125 mg Pycnogenol ® daily for 3 months. Regarding endotheliitis, Pycnogenol ® studies offer good evidence for potential beneficial effects for patients suffering from COVID-19 by improving endothelial function. As Pycnogenol ® offers antioxidant and anti-inflammatory activities and positively influences endothelial cell function as well as microcirculation and platelet reactivity, a supplementation might support the management of COVID-19 patients. We hypothesize possible additional beneficial effects of Pycnogenol ® in patients infected with the new coronavirus SARS-CoV2 and those who suffer from abiding health problems, when complemented to the standard treatment also upon the first day of symptoms or infection. abstract: Corona Virus Disease 2019 (COVID-19) is triggered by the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV2) and has rapidly developed into a worldwide pandemic. Unlike other SARS viruses, SARS-CoV2 does not solely impact the respiratory system, but additionally leads to inflammation of endothelial cells, microvascular injuries and coagulopathies, thereby affecting multiple organs. Recent reports of patients that were infected with SARS-CoV2 suggest persistent health problems even months after the initial infection. In over 90 human clinical studies, the French maritime pine bark extract Pycnogenol® demonstrated anti-inflammatory, vascular and endothelium-protective effects. We propose that Pycnogenol® may be beneficial in supporting recovery and mitigating symptoms and long-term consequences resulting from a SARS-CoV2 infection in COVID-19 patients. url: https://www.sciencedirect.com/science/article/pii/S0924857920303976?v=s5 doi: 10.1016/j.ijantimicag.2020.106191 id: cord-344191-veug3dae author: Weiling, Lydia Li title: Digital health for patients with chronic pain during the COVID-19 pandemic date: 2020-08-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0007091220306449?v=s5 doi: 10.1016/j.bja.2020.08.003 id: cord-028285-n4dommet author: Weilongorska, Natasha L. title: COVID-19: What are the challenges for NHS surgery? date: 2020-07-02 words: 9755.0 sentences: 619.0 pages: flesch: 46.0 cache: ./cache/cord-028285-n4dommet.txt txt: ./txt/cord-028285-n4dommet.txt summary: With there being a short interval from the time of the first COVID-19 case presentation, to the development of a global pandemic, validated management algorithms to support changes in operative strategies are lacking. The key components of NHS preoperative patient screening for COVID-19 are: structured questionnaires with temperature monitoring, viral real-time polymerase chain reaction (RT PCR) for SARS-CoV-2, and chest imaging. Full PPE (fluid resistant gown, double gloving, visor or goggles, fit-tested FFP3 mask or respirator, disposable hat, shoe covers) should be worn in the operating rooms for any suspected or positive COVID-19 case, for AGP 38 (Table 3) , and for procedures for which the risk is unknown. All surgical cases require a discussion about the patient''s COVID-19 status, the degree of aerosol risk for each part of the procedure (induction of anaesthesia, extubation, and for all operative phases), with PPE requirement stated for each stage. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329670/ doi: 10.1016/j.cpsurg.2020.100856 id: cord-343897-f4imrltt author: Weimer, Louis H. title: Neuromuscular disorders in pregnancy date: 2020-08-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Many neuromuscular disorders preexist or occur during pregnancy. In some cases, pregnancy unmasks a latent hereditary disorder. Most available information is based on case reports or series or retrospective clinical experience or patient surveys. Of special interest are pregnancy-induced changes in disease course or severity and likelihood for baseline recovery of function postpartum. Labor and delivery present special challenges in many conditions that affect skeletal but not smooth (uterine) muscle; so labor complications must be anticipated. Anesthesia for cesarean section surgery requires special precautions in many disorders. The types of conditions reviewed are broad and include examples of autoimmune, hereditary, and compressive/mechanical processes. Disorders include carpal tunnel syndrome and other focal neuropathies, Bell palsy, myasthenia gravis, and other neuromuscular junction disorders, acute and chronic inflammatory neuropathy, hereditary and acquired muscle diseases, spinal muscular atrophy, amyotrophic lateral sclerosis, channelopathies, autonomic neuropathy, and dysautonomia. Many commonly used therapies have fetal animal but no proven human toxicity concerns, complicating treatment and risk decisions. Weaning off effective therapeutic agents or preemptive aggressive treatment or surgery prior to planned pregnancy is an option in some conditions. url: https://www.sciencedirect.com/science/article/pii/B978044464240000012X doi: 10.1016/b978-0-444-64240-0.00012-x id: cord-021816-gk8rwyq4 author: Weinberger, Steven E. title: Pneumonia date: 2018-02-22 words: 7586.0 sentences: 365.0 pages: flesch: 33.0 cache: ./cache/cord-021816-gk8rwyq4.txt txt: ./txt/cord-021816-gk8rwyq4.txt summary: In practice, several factors frequently cause enough impairment of host defenses to contribute to the development of pneumonia, even though individuals with such impairment are not considered "immunosuppressed." Viral upper respiratory tract infections, ethanol abuse, cigarette smoking, heart failure, and preexisting chronic obstructive pulmonary disease (COPD) are a few of the contributing factors. Three major settings in which this organism is seen as a cause of pneumonia are (1) as a secondary complication of respiratory tract infection with the influenza virus; (2) in the hospitalized patient, who often has some impairment of host defense mechanisms and whose oropharynx has been colonized by Staphylococcus; and (3) as a complication of widespread dissemination of staphylococcal organisms through the bloodstream. One issue that has sparked controversy is whether an attempt should be made to identify a specific etiologic agent, using Gram stain and culture, in patients with community-acquired pneumonia, or whether empirical therapy should be used based on the patient''s risk factors, clinical characteristics, and local bacterial resistance patterns. abstract: By nearly any criteria, pneumonia (infection of the pulmonary parenchyma) must be considered one of the most important categories of disease affecting the respiratory system. This chapter is organized primarily as a general discussion of the clinical problem of pneumonia. As appropriate, the focus on individual etiologic agents highlights some characteristic features of each that are particularly useful to the physician. Also covered is a commonly used categorization of pneumonia based on the clinical setting: community-acquired versus nosocomial (hospital-acquired) pneumonia. In current clinical practice, the approach to evaluation and management of these two types of pneumonia is often quite different. The chapter concludes with a brief discussion of several infections that were uncommon or primarily of historical interest until recently, as the threat of bioterrorism emerged. In addition to reviewing inhalational anthrax, the chapter briefly describes two other organisms considered to be of concern as potential weapons of bioterrorism: Yersinia pestis (the cause of plague) and Francisella tularensis (the cause of tularemia). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152063/ doi: 10.1016/b978-0-323-52371-4.00026-x id: cord-277210-xaj2623u author: Weinkove, Robert title: Managing haematology and oncology patients during the COVID‐19 pandemic: interim consensus guidance date: 2020-05-13 words: 6044.0 sentences: 315.0 pages: flesch: 38.0 cache: ./cache/cord-277210-xaj2623u.txt txt: ./txt/cord-277210-xaj2623u.txt summary: • Adopt measures within cancer centres to reduce risk of nosocomial SARS-CoV-2 acquisition; support population-wide social distancing; reduce demand on acute services; ensure adequate staffing; and provide culturally safe care. Patients with cancer could be at elevated risk of severe COVID-19, while delivery of cancer therapies could be disrupted by quarantines, social distancing measures, and interruption of routine health care delivery by the pandemic. 38 Community spread of COVID-19 has the potential to diminish the donor pool, to threaten the capacity of cancer services to provide routine transfusion support, and to increase the risks that transfusion-dependent patients will come into contact with other individuals with SARS-CoV-2. We present interim guidance for clinicians caring for patients with cancer who may be particularly vulnerable both to severe COVID-19 and the potential impact of the pandemic on the provision of cancer investigations and treatment. abstract: INTRODUCTION: A pandemic coronavirus, SARS‐CoV‐2, causes COVID‐19, a potentially life‐threatening respiratory disease. Patients with cancer may have compromised immunity due to their malignancy and/or treatment, and may be at elevated risk of severe COVID‐19. Community transmission of COVID‐19 could overwhelm health care services, compromising delivery of cancer care. This interim consensus guidance provides advice for clinicians managing patients with cancer during the pandemic. MAIN RECOMMENDATIONS: During the COVID‐19 pandemic: In patients with cancer with fever and/or respiratory symptoms, consider causes in addition to COVID‐19, including other infections and therapy‐related pneumonitis. For suspected or confirmed COVID‐19, discuss temporary cessation of cancer therapy with a relevant specialist. Provide information on COVID‐19 for patients and carers. Adopt measures within cancer centres to reduce risk of nosocomial SARS‐CoV‐2 acquisition; support population‐wide social distancing; reduce demand on acute services; ensure adequate staffing; and provide culturally safe care. Measures should be equitable, transparent and proportionate to the COVID‐19 threat. Consider the risks and benefits of modifying cancer therapies due to COVID‐19. Communicate treatment modifications, and review once health service capacity allows. Consider potential impacts of COVID‐19 on the blood supply and availability of stem cell donors. Discuss and document goals of care, and involve palliative care services in contingency planning. CHANGES IN MANAGEMENT AS A RESULT OF THIS STATEMENT: This interim consensus guidance provides a framework for clinicians managing patients with cancer during the COVID‐19 pandemic. In view of the rapidly changing situation, clinicians must also monitor national, state, local and institutional policies, which will take precedence. ENDORSED BY: Australasian Leukaemia and Lymphoma Group; Australasian Lung Cancer Trials Group; Australian and New Zealand Children's Haematology/Oncology Group; Australia and New Zealand Society of Palliative Medicine; Australasian Society for Infectious Diseases; Bone Marrow Transplantation Society of Australia and New Zealand; Cancer Council Australia; Cancer Nurses Society of Australia; Cancer Society of New Zealand; Clinical Oncology Society of Australia; Haematology Society of Australia and New Zealand; National Centre for Infections in Cancer; New Zealand Cancer Control Agency; New Zealand Society for Oncology; and Palliative Care Australia. url: https://doi.org/10.5694/mja2.50607 doi: 10.5694/mja2.50607 id: cord-321311-v2i1caug author: Weller, Michael title: How we treat patients with brain tumour during the COVID-19 pandemic date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The COVID-19 pandemic has created major insecurities regarding whether we can and should maintain the current standards of diagnosis and treatment and access to care for patients with cancer. This is particularly true in the field of neuro-oncology, where the perceived benefit of therapeutic interventions is often low, although this notion is partially incorrect. We acknowledge that the recommendations for care of patients with cancer have become a moving target and that all recommendations are subject to modification based on national and institutional regulations. Still, some important considerations and proposals may apply broadly. First, it is important to note that old age and cardiovascular and pulmonary co-morbidities are the major risk factors for experiencing a severe course of and for dying of COVID-19, not chronic immunosuppression and cancer. Second, many of the considerations on how we should adapt clinical practice in neuro-oncology in view of COVID-19 that are now dominating discussions at local tumour boards, as well as on the institutional level and within societies of neuro-oncology, are not novel but have been valid before and only now have become a priority. More than ever, it seems to be mandatory to adhere to evidence-based medicine and not to prescribe potentially toxic, notably immunsuppresssive systemic therapy where evidence for efficacy is low. Furthermore, it is more obvious now that oncologists must not miss the right time for advance care planning, that is, supporting patients in understanding and sharing their personal values, life goals and preferences regarding future medical care. The major psychological impact of transforming oncology care to teleconferences and videoconferences and of the important strict recommendation of social distancing must not be overlooked in a patient population that is characterised by significant prevalence of cognitive decline and by the general perception that their life span may not exceed the life span of the COVID-19 pandemic url: https://doi.org/10.1136/esmoopen-2020-000789 doi: 10.1136/esmoopen-2020-000789 id: cord-291566-jwlvustd author: Wells Mulherin, Diana title: ASPEN Report on Nutrition Support Practice Processes With COVID‐19: The First Response date: 2020-07-16 words: 5727.0 sentences: 272.0 pages: flesch: 49.0 cache: ./cache/cord-291566-jwlvustd.txt txt: ./txt/cord-291566-jwlvustd.txt summary: This paper summarizes clinician reports on these changed processes, including overall nutrition care, nutrition assessment, enteral nutrition and parenteral nutrition care steps, and food and oral supplement delivery. Experience and research on nutrition support therapy in patients with COVID-19 has brought about new healthcare practice processes that include telemedicine, personal protective equipment (PPE), and exposure limitations. Inpatient nutrition support clinicians working from home have found it challenging to be involved in patient care rounds. Nutrition clinicians are also using telephone or video conferencing to round with the primary medical teams to see patients together and limit going into patients'' rooms to minimize COVID-19 exposure. Some dietitians are reporting that patients with COVID-19 infections are in negative-pressure rooms, and therefore they do not need to wear entire PPE on the patient care unit, which allows them greater access to other healthcare professionals. abstract: Coronavirus disease 2019 (COVID‐19) has changed nutrition care processes in hospitals and in the home setting. This paper summarizes clinician reports on these changed processes, including overall nutrition care, nutrition assessment, enteral nutrition and parenteral nutrition care steps, and food and oral supplement delivery. Also included are teaching, logistics, and personnel issues around changes in the work environment. Use of safe, standardized, evidence‐based processes in the face of altered care patterns is critical. url: https://www.ncbi.nlm.nih.gov/pubmed/32671870/ doi: 10.1002/ncp.10553 id: cord-320572-94fvtj4a author: Wendel Garcia, Pedro David title: Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated with a high disease burden with 10% of confirmed cases progressing towards critical illness. Nevertheless, the disease course and predictors of mortality in critically ill patients are poorly understood. METHODS: Following the critical developments in ICUs in regions experiencing early inception of the pandemic, the European-based, international RIsk Stratification in COVID-19 patients in the Intensive Care Unit (RISC-19-ICU) registry was created to provide near real-time assessment of patients developing critical illness due to COVID-19. FINDINGS: As of April 22, 2020, 639 critically ill patients with confirmed SARS-CoV-2 infection were included in the RISC-19-ICU registry. Of these, 398 had deceased or been discharged from the ICU. ICU-mortality was 24%, median length of stay 12 (IQR, 5–21) days. ARDS was diagnosed in 74%, with a minimum P/F-ratio of 110 (IQR, 80–148). Prone positioning, ECCO2R, or ECMO were applied in 57%. Off-label therapies were prescribed in 265 (67%) patients, and 89% of all bloodstream infections were observed in this subgroup (n = 66; RR=3·2, 95% CI [1·7–6·0]). While PCT and IL-6 levels remained similar in ICU survivors and non-survivors throughout the ICU stay (p = 0·35, 0·34), CRP, creatinine, troponin, d-dimer, lactate, neutrophil count, P/F-ratio diverged within the first seven days (p<0·01). On a multivariable Cox proportional-hazard regression model at admission, creatinine, d-dimer, lactate, potassium, P/F-ratio, alveolar-arterial gradient, and ischemic heart disease were independently associated with ICU-mortality. INTERPRETATION: The European RISC-19-ICU cohort demonstrates a moderate mortality of 24% in critically ill patients with COVID-19. Despite high ARDS severity, mechanical ventilation incidence was low and associated with more rescue therapies. In contrast to risk factors in hospitalized patients reported in other studies, the main mortality predictors in these critically ill patients were markers of oxygenation deficit, renal and microvascular dysfunction, and coagulatory activation. Elevated risk of bloodstream infections underscores the need to exercise caution with off-label therapies. url: https://api.elsevier.com/content/article/pii/S2589537020301930 doi: 10.1016/j.eclinm.2020.100449 id: cord-028590-rw0okd0p author: Westgarth, David title: What does the future hold for the workforce of tomorrow? date: 2020-07-06 words: 4657.0 sentences: 222.0 pages: flesch: 62.0 cache: ./cache/cord-028590-rw0okd0p.txt txt: ./txt/cord-028590-rw0okd0p.txt summary: ''Many hospitals have had to adapt to become urgent dental care hubs during the peak of the pandemic, with both the hospitals I work in beginning to start to resume some '' According to a new poll by the mental health charity Mind, many people who were previously well will develop mental health problems as a ''direct consequence of the pandemic and all that follows'', with the worst yet to come.'' routine services. '' As always, the impact will be greatest on the most vulnerable of the profession: new graduates, many of whom have lost their part-time jobs; young dentists leaving dental foundation training and potentially struggling to find their first associateship; and dental care professional colleagues who are significantly affected by the closure of practices and the expected lengthy return to the provision of dentistry over the coming months. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336097/ doi: 10.1038/s41404-020-0457-x id: cord-024189-t7mbsr25 author: Weyand, Cornelia M. title: Vasculitides date: 2008 words: 26631.0 sentences: 1415.0 pages: flesch: 40.0 cache: ./cache/cord-024189-t7mbsr25.txt txt: ./txt/cord-024189-t7mbsr25.txt summary: A relatively disease-specifi c manifestation of GCA that is present in about half of the patients is jaw claudication: pain in the masseter or temporalis muscles caused by compromised blood fl ow in the extracranial branches of the carotid artery. Although a high erythrocyte sedimentation rate (ESR) is usually considered a hallmark of GCA, in a recent study 25% of all patients with positive temporal artery biopsies had normal ESRs before the initiation of glucocorticoid therapy (16) . Upregulation of acute phase reactants is helpful in distinguishing PMR from other pain syndromes, yet (as in GCA and TA) not all patients with active disease have elevated markers of infl ammation within their serum. Kawasaki''s disease (KD), once known as mucocutaneous lymph node syndrome, is a systemic infl ammatory disorder occurring in children that is accompanied by vasculitis and a risk of coronary artery aneurysms. abstract: Despite the spatial closeness of blood vessels and inflammatory cells, blood vessel walls are infrequently targeted by inflammation. Giant cell arteritis (GCA) and Takayasu’s arteritis (TA) are characterized by inflammation directed against the vessel wall. GCA and TA display stringent tissue tropism and affect defined vascular territories in a preferential manner. GCA predominantly affects the second- to fifth-order aortic branches, often in the extracranial arteries of the head. The aorta itself may also be affected in GCA, albeit less often than other regions. In contrast, in TA, the aorta and its major branches are the prime disease targets. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193731/ doi: 10.1007/978-0-387-68566-3_21 id: cord-302684-r4ger87o author: Whisenant, Jennifer G. title: TERAVOLT: Thoracic Cancers International COVID-19 Collaboration date: 2020-05-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Prior publications on small subsets of cancer patients infected with SARS CoV-2 have shown an increased risk of mortality compared to the general population. Furthermore, patients with thoracic malignancies are thought to be at particularly high risk given their older age, smoking habits, and pre-existing cardio-pulmonary comorbidities. For this reason, physicians around the world have formed TERAVOLT, a global consortium dedicated to understanding the impact of COVID-19 on patients with thoracic malignancies. url: https://www.sciencedirect.com/science/article/pii/S1535610820302580?v=s5 doi: 10.1016/j.ccell.2020.05.008 id: cord-354720-fu19u2b0 author: White-Dzuro, Gabrielle title: Multisystem effects of COVID-19: a concise review for practitioners date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: While COVID-19 has primarily been characterized by the respiratory impact of viral pneumonia, it affects every organ system and carries a high consequent risk of death in critically ill patients. Higher sequential organ failure assessment (SOFA) scores have been associated with increased mortality in patients critically ill patients with COVID-19. It is important that clinicians managing critically ill COVID-19 patients be aware of the multisystem impact of the disease so that care can be focused on the prevention of end-organ injuries to potentially improve clinical outcomes. We review the multisystem complications of COVID-19 and associated treatment strategies to improve the care of critically ill COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32921198/ doi: 10.1080/00325481.2020.1823094 id: cord-355146-6rat5j64 author: Whittemore, Paul title: Use of awake proning to avoid invasive ventilation in a patient with severe COVID-19 pneumonitis date: 2020-08-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A 60-year-old man with swab-positive COVID-19 and extensive ground-glass change seen on CT imaging was successfully managed on our COVID-19 high-dependency unit with only low-flow oxygen and strict awake proning instructions. He was successfully weaned off oxygen entirely without any requirement for non-invasive or invasive ventilation and made a recovery to be discharged home after an 18-day hospital stay. url: https://www.ncbi.nlm.nih.gov/pubmed/32747596/ doi: 10.1136/bcr-2020-236586 id: cord-347268-vb6z0hzb author: Wicclair, Mark R. title: Is conscientious objection incompatible with a physician’s professional obligations? date: 2008-08-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In response to physicians who refuse to provide medical services that are contrary to their ethical and/or religious beliefs, it is sometimes asserted that anyone who is not willing to provide legally and professionally permitted medical services should choose another profession. This article critically examines the underlying assumption that conscientious objection is incompatible with a physician’s professional obligations (the “incompatibility thesis”). Several accounts of the professional obligations of physicians are explored: general ethical theories (consequentialism, contractarianism, and rights-based theories), internal morality (essentialist and non-essentialist conceptions), reciprocal justice, social contract, and promising. It is argued that none of these accounts of a physician’s professional obligations unequivocally supports the incompatibility thesis. url: https://www.ncbi.nlm.nih.gov/pubmed/18752039/ doi: 10.1007/s11017-008-9075-z id: cord-031734-5wnvuk2n author: Wichlas, F. title: War surgery in Afghanistan: a model for mass causalities in terror attacks? date: 2020-09-11 words: 3120.0 sentences: 196.0 pages: flesch: 57.0 cache: ./cache/cord-031734-5wnvuk2n.txt txt: ./txt/cord-031734-5wnvuk2n.txt summary: PURPOSE: The aim of the study was to identify solution strategies from a non-governmental (NGO) hospital in a war region for violence-related injuries and to show how high-income countries (HIC) might benefit from this expertise. Apart from surgical wound care and debridements, which were performed on every wound in the operation theatre, laparotomy was the most common surgical procedure, followed by installation of a chest drainage and amputation. The lack of surgical experience might not be relevant as long as a hospital provides a specialist for every probable pathology, but in cases of a sudden high volume of causalities like in a terror attack or train accident, adequate treatment of the injured could get difficult [7, 8] . As much as medical standards in LIC and war zones lag behind, there might be a potential knowledge of primary injury treatment and basic surgical techniques, expectable injury patterns, and experience in dealing with mass causalities by fast decision-making. abstract: PURPOSE: The aim of the study was to identify solution strategies from a non-governmental (NGO) hospital in a war region for violence-related injuries and to show how high-income countries (HIC) might benefit from this expertise. METHODS: NGO trauma hospital in Lashkar Gah, Afghanistan. Four hundred eighty-four war victims admitted in a three month period (February 2016–May 2016) were included. Patients´ characteristics were analyzed. RESULTS: The mean age was 23.5 years. Four hundred thirty-four (89.9%) were male, and 50 (10.1%) were female. The most common cause of injury was bullet injuries, shell injuries, and mine injuries. The most common injured body region was the lower extremity, upper extremity, and the chest or the face. Apart from surgical wound care and debridements, which were performed on every wound in the operation theatre, laparotomy was the most common surgical procedure, followed by installation of a chest drainage and amputation. CONCLUSION: The surgical expertise and clear pathways outweigh modern infrastructure. In case of a mass casualty incident, fast decision-making with basic diagnostic means in order to take rapid measurements for life-saving therapies could make the difference. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00264-020-04797-2) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483489/ doi: 10.1007/s00264-020-04797-2 id: cord-267124-8efdzlc0 author: Wichmann, Dominic title: Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study date: 2020-05-06 words: 4062.0 sentences: 240.0 pages: flesch: 50.0 cache: ./cache/cord-267124-8efdzlc0.txt txt: ./txt/cord-267124-8efdzlc0.txt summary: In response to the pandemic spread of SARS-CoV-2, the authorities of the German federal state of Hamburg ordered mandatory autopsies in all patients dying with a diagnosis of COVID-19 confirmed by polymerase chain reaction (PCR). During autopsy, tissue samples for histology were taken from the following organs: heart, lungs, liver, kidneys, spleen, pancreas, brain, prostate and testes (in males), ovaries (in females), small bowel, saphenous vein, common carotid artery, pharynx, and muscle. In this autopsy study of 12 consecutive patients who died of COVID-19, we found a high incidence of deep venous thrombosis (58%). In studies that examined deceased patients with COVID-19 without relying on autopsy, no increased rates of pulmonary embolism were observed clinically. To our knowledge, only 3 case reports have been published on patients with COVID-19 who have undergone complete autopsy and a few more in which only lung tissue was examined (7, 8) . abstract: BACKGROUND: The new coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2), has caused more than 210 000 deaths worldwide. However, little is known about the causes of death and the virus's pathologic features. OBJECTIVE: To validate and compare clinical findings with data from medical autopsy, virtual autopsy, and virologic tests. DESIGN: Prospective cohort study. SETTING: Autopsies performed at a single academic medical center, as mandated by the German federal state of Hamburg for patients dying with a polymerase chain reaction–confirmed diagnosis of COVID-19. PATIENTS: The first 12 consecutive COVID-19–positive deaths. MEASUREMENTS: Complete autopsy, including postmortem computed tomography and histopathologic and virologic analysis, was performed. Clinical data and medical course were evaluated. Results: Median patient age was 73 years (range, 52 to 87 years), 75% of patients were male, and death occurred in the hospital (n = 10) or outpatient sector (n = 2). Coronary heart disease and asthma or chronic obstructive pulmonary disease were the most common comorbid conditions (50% and 25%, respectively). Autopsy revealed deep venous thrombosis in 7 of 12 patients (58%) in whom venous thromboembolism was not suspected before death; pulmonary embolism was the direct cause of death in 4 patients. Postmortem computed tomography revealed reticular infiltration of the lungs with severe bilateral, dense consolidation, whereas histomorphologically diffuse alveolar damage was seen in 8 patients. In all patients, SARS–CoV-2 RNA was detected in the lung at high concentrations; viremia in 6 of 10 and 5 of 12 patients demonstrated high viral RNA titers in the liver, kidney, or heart. LIMITATION: Limited sample size. CONCLUSION: The high incidence of thromboembolic events suggests an important role of COVID-19–induced coagulopathy. Further studies are needed to investigate the molecular mechanism and overall clinical incidence of COVID-19–related death, as well as possible therapeutic interventions to reduce it. PRIMARY FUNDING SOURCE: University Medical Center Hamburg-Eppendorf. url: https://www.ncbi.nlm.nih.gov/pubmed/32374815/ doi: 10.7326/m20-2003 id: cord-034286-m1c98nv7 author: Wijdicks, Eelco F. M. title: Communicating Neurocritical Illness: The Anatomy of Misunderstanding date: 2020-10-27 words: 3537.0 sentences: 244.0 pages: flesch: 54.0 cache: ./cache/cord-034286-m1c98nv7.txt txt: ./txt/cord-034286-m1c98nv7.txt summary: One starting point for those practicing acute neurology and neurocritical care is a new mnemonic TELL ME (Time course, Essence, Laboratory, Life-sustaining interventions, Management, Expectation), which will assist physicians in standardizing their communication skills before they start a conversation or pick up a phone. These include knowing the time course (new and "out of the blue" or ongoing for some time); extracting the essentials (eliminating all irrelevancies); communicating what tests are known and pending (computerized tomography and laboratory); relaying how much critical support will be needed (secretion burden, intubation, vasopressors); knowing fully which emergency drugs have been administered (e.g., mannitol, antiepileptics, tranexamic acid), when transport is anticipated, and what can be expected in the following hours. In any case, improved provider perceptions of transfer workflow efficiency and patient safety may not be enough; communication must also include solutions for active medical problems and an outline of anticipatory guidance ("what if-what then" scenarios) in the event an acute change in clinical condition occurs. abstract: We talk, text, email all day. Do we perceive things correctly? Do we need to improve the way we communicate? It is a truism that providing insufficient information about a patient results in delays and errors in management. How can we best communicate urgent triage or urgent changes in the patient condition? There is no substitute for a face-to-face conversation but what would the receiving end want to know? One starting point for those practicing acute neurology and neurocritical care is a new mnemonic TELL ME (Time course, Essence, Laboratory, Life-sustaining interventions, Management, Expectation), which will assist physicians in standardizing their communication skills before they start a conversation or pick up a phone. These include knowing the time course (new and "out of the blue" or ongoing for some time); extracting the essentials (eliminating all irrelevancies); communicating what tests are known and pending (computerized tomography and laboratory); relaying how much critical support will be needed (secretion burden, intubation, vasopressors); knowing fully which emergency drugs have been administered (e.g., mannitol, antiepileptics, tranexamic acid), when transport is anticipated, and what can be expected in the following hours. Perfect orchestration in communication may be too much to ask, but we neurointensivists strive to convey information accurately and completely. Communication must be taught, learned, and practiced. This article provides guiding principles for a number of scenarios involving communication inside and outside the hospital. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588280/ doi: 10.1007/s12028-020-01131-x id: cord-345546-v7t26oos author: Wilenius, Lukas title: Attention-Deficit/Hyperactivity Disorder Patients May Have Undiagnosed Narcolepsy date: 2020-06-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background Attention-deficit/hyperactivity disorder (ADHD) patients have many comorbidities. Narcoleptic patients have a big prevalence of ADHD (15%-30%). Both groups suffer from similar symptoms and benefit from the same class of medications. As such, narcolepsy could be masked in ADHD patients. Low serum ferritin has been found both in ADHD patients as well as in patients with narcolepsy. Materials & methods We enrolled 26 participants (14 ADHD patients and 12 controls). They answered several questionnaires, and blood samples were obtained from 20 participants. We had clear exclusion criteria. Results Using the Ullanlinna Narcolepsy Scale (UNS), we identified three possible narcolepsy patients within the ADHD group and no suspects in the control group. There was a statistically significant negative correlation between serum iron levels and ADHD symptom severity. No correlation was found measuring serum ferritin levels. Conclusions Narcolepsy may be more common within ADHD patients than in the general population. Some of these patients could benefit from a change in medication. Low serum iron and ferritin levels could be relevant in ADHD pathophysiology. This requires further exploratory research. url: https://doi.org/10.7759/cureus.8436 doi: 10.7759/cureus.8436 id: cord-323980-rcyjthze author: Willems, Laurent M. title: SARS-CoV-2-related rapid reorganization of an epilepsy outpatient clinic from personal appointments to telemedicine services: A German single-center experience date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: When the SARS-CoV-2 pandemic reached Europe in 2020, a German governmental order forced clinics to immediately suspend elective care, causing a problem for patients with chronic illnesses such as epilepsy. Here, we report the experience of one clinic that converted its outpatient care from personal appointments to telemedicine services. METHODS: Documentations of telephone contacts and telemedicine consultations at the Epilepsy Center Frankfurt Rhine-Main were recorded in detail between March and May 2020 and analyzed for acceptance, feasibility, and satisfaction of the conversion from personal to telemedicine appointments from both patients' and medical professionals' perspectives. RESULTS: Telephone contacts for 272 patients (mean age: 38.7 years, range: 17–79 years, 55.5% female) were analyzed. Patient-rated medical needs were either very urgent (6.6%, n = 18), urgent (23.5%, n = 64), less urgent (29.8%, n = 81), or nonurgent (39.3%, n = 107). Outpatient service cancelations resulted in a lack of understanding (9.6%, n = 26) or anger and aggression (2.9%, n = 8) in a minority of patients, while 88.6% (n = 241) reacted with understanding, or relief (3.3%, n = 9). Telemedicine consultations rather than a postponed face-to-face visit were requested by 109 patients (40.1%), and these requests were significantly associated with subjective threat by SARS-CoV-2 (p = 0.004), urgent or very urgent medical needs (p = 0.004), and female gender (p = 0.024). Telemedicine satisfaction by patients and physicians was high. Overall, 9.2% (n = 10) of patients reported general supply problems due to SARS-CoV-2, and 28.4% (n = 31) reported epilepsy-specific problems, most frequently related to prescriptions, or supply problems for antiseizure drugs (ASDs; 22.9%, n = 25). CONCLUSION: Understanding and acceptance of elective ambulatory visit cancelations and the conversion to telemedicine consultations was high during the coronavirus disease 2019 (COVID-19) lockdown. Patients who engaged in telemedicine consultations were highly satisfied, supporting the feasibility and potential of telemedicine during the COVID-19 pandemic and beyond. url: https://www.ncbi.nlm.nih.gov/pubmed/33181898/ doi: 10.1016/j.yebeh.2020.107483 id: cord-315424-i3nnennw author: Willer, Brittany L. title: The otolaryngologist’s and anesthesiologist’s collaborative role in a pandemic: a large quaternary pediatric center’s experience with COVID-19 preparation and simulation date: 2020-06-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There has been a rapid global spread of a novel coronavirus, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which originated in Wuhan China in late 2019. A serious threat of nosocomial spread exists and as such, there is a critical necessity for well-planned and rehearsed processes during the care of the COVID-19 positive and suspected patient to minimize transmission and risk to healthcare providers and other patients. Because of the aerosolization inherent in airway management, the pediatric otolaryngologist and anesthesiologist should be intimately familiar with strategies to mitigate the high-risk periods of viral contamination that are posed to the environment and healthcare personnel during tracheal intubation and extubation procedures. Since both the pediatric otolaryngologist and anesthesiologist are directly involved in emergency airway interventions, both specialties impact the safety of caring for COVID-19 patients and are a part of overall hospital pandemic preparedness. We describe our institutional approach to COVID-19 perioperative pandemic planning at a large quaternary pediatric hospital including operating room management and remote airway management. We outline our processes for the safe and effective care of these patients with emphasis on simulation and pathways necessary to protect healthcare workers and other personnel from exposure while still providing safe, effective, and rapid care. url: https://doi.org/10.1016/j.ijporl.2020.110174 doi: 10.1016/j.ijporl.2020.110174 id: cord-322868-o3r0y6bz author: Williams, E. J. title: Routine measurement of serum procalcitonin allows antibiotics to be safely withheld in patients admitted to hospital with SARS-CoV-2 infection. date: 2020-07-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. It can be a diagnostic challenge to identify COVID-19 patients without bacterial co-infection in whom antibiotics can be safely stopped. We sought to evaluate the validity of a guideline that recommends withholding antibiotics in patients with a low serum procalcitonin (PCT). Methods. We retrospectively collected 28-day outcome data on patients admitted to Sheffield Teaching Hospitals NHS Foundation Trust, UK, between 5 March and 15 April 2020, with a positive SARS-CoV-2 polymerase chain reaction (PCR) and PCT within 48 hours of diagnosis. PCT was considered negative if [≤]0.25ng/ml and positive if >0.25ng/ml. Primary outcomes included antibiotic consumption, mortality, intensive care admission and length of hospital stay. Results. 368 patients met the inclusion criteria; 218 (59%) had a negative PCT and 150 (41%) positive. At 48 hours post-diagnosis, 73 (33%) of those with a negative PCT were receiving antimicrobials compared to 126 (84%) with a positive PCT (p<0.001), with a corresponding reduction in antimicrobial usage over 28 days (median DDD of 3.0 vs 6.8 (p<0.001); median DOT 2 vs 5 days (p<0.001) between the negative and positive PCT groups.) In the negative PCT group, there were fewer deaths (62 (28%) vs. 54 (36%), (p=0.021)) and critical care admissions (19 (9%) vs. 28 (19%), (p=0.007)) than in the positive PCT group. Median length of hospital stay was 8.7 and 9 days in the negative and positive PCT groups respectively. Conclusions. Procalcitonin is a valuable tool in the assessment of patients with SARS-CoV-2 infection, safely reducing the potential burden of unnecessary antibiotic usage. url: https://doi.org/10.1101/2020.06.29.20136572 doi: 10.1101/2020.06.29.20136572 id: cord-303065-dyg2baog author: Williams, Michael title: Patient-Centered Surgical Care Meets the Social Determinants of Health date: 2020-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s00268-020-05785-8 doi: 10.1007/s00268-020-05785-8 id: cord-353401-y1mxnth7 author: Williams, Roger D. title: Moral Injury in Times of COVID-19 date: 2020-05-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Health care providers are facing increased risk of moral distress during the COVID-19 pandemic because of changes in clinical practice and resource allocation procedures. Health care systems that employ a proactive approach in mitigating the lasting effects of moral distress will fare better in the long run. Psychologists are well poised to apply timely psychological first aid to the crisis needs of patients, colleagues, and even themselves. Key interventions are detailed, including creating and promoting safety, calmness, connectedness, self-efficacy, and hope. url: https://doi.org/10.1007/s42843-020-00011-4 doi: 10.1007/s42843-020-00011-4 id: cord-281332-5mddyv0n author: Wilson, Michael R. title: A novel cause of chronic viral meningoencephalitis: Cache Valley virus date: 2017-07-25 words: 4008.0 sentences: 232.0 pages: flesch: 42.0 cache: ./cache/cord-281332-5mddyv0n.txt txt: ./txt/cord-281332-5mddyv0n.txt summary: Interpretation: Cache Valley virus, a mosquito-borne orthobunyavirus, has only been identified in 3 immunocompetent North American patients with acute neuroinvasive disease. This report demonstrates that metagenomic next generation sequencing allows for unbiased pathogen identification, the early detection of emerging viruses as they spread to new locales, and the discovery of novel disease phenotypes. This report demonstrates that metagenomic next generation sequencing allows for unbiased pathogen identification, the early detection of emerging viruses as they spread to new locales, and the discovery of novel disease phenotypes. Here, we report the effective deployment of metagenomic next generation sequencing (mNGS) to diagnose Cache Valley virus (CVV), a mosquito-borne orthobunyavirus, 4 in an Australian patient with a primary immunodeficiency suffering from chronic meningoencephalitis. 41 Because CVV is rarely identified as a cause of human disease and has not been reported in Australia previously, there are no traditional candidate-based diagnostic tests for this virus available in Australia. abstract: OBJECTIVE: Immunodeficient patients are particularly vulnerable to neuroinvasive infections that can be challenging to diagnose. Metagenomic next generation sequencing can identify unusual or novel microbes and is therefore well suited for investigating the etiology of chronic meningoencephalitis in immunodeficient patients. METHODS: We present the case of a 34‐year‐old man with X‐linked agammaglobulinemia from Australia suffering from 3 years of meningoencephalitis that defied an etiologic diagnosis despite extensive conventional testing, including a brain biopsy. Metagenomic next generation sequencing of his cerebrospinal fluid and brain biopsy tissue was performed to identify a causative pathogen. RESULTS: Sequences aligning to multiple Cache Valley virus genes were identified via metagenomic next generation sequencing. Reverse transcription polymerase chain reaction and immunohistochemistry subsequently confirmed the presence of Cache Valley virus in the brain biopsy tissue. INTERPRETATION: Cache Valley virus, a mosquito‐borne orthobunyavirus, has only been identified in 3 immunocompetent North American patients with acute neuroinvasive disease. The reported severity ranges from a self‐limiting meningitis to a rapidly fatal meningoencephalitis with multiorgan failure. The virus has never been known to cause a chronic systemic or neurologic infection in humans. Cache Valley virus has also never previously been detected on the Australian continent. Our research subject traveled to North and South Carolina and Michigan in the weeks prior to the onset of his illness. This report demonstrates that metagenomic next generation sequencing allows for unbiased pathogen identification, the early detection of emerging viruses as they spread to new locales, and the discovery of novel disease phenotypes. Ann Neurol 2017;82:105–114 url: https://doi.org/10.1002/ana.24982 doi: 10.1002/ana.24982 id: cord-021905-fjcks7w4 author: Win, Patrick H. title: Asthma Triggers: What Really Matters? date: 2009-05-22 words: 5991.0 sentences: 297.0 pages: flesch: 42.0 cache: ./cache/cord-021905-fjcks7w4.txt txt: ./txt/cord-021905-fjcks7w4.txt summary: The level of cat allergen that is required to induce asthma symptoms is not well defined, so strict avoidance and proper cleaning after an animal has been removed from the household are key to preventing morbidity. Accordingly, improper setting of the central air humidifier (commonly part of a home''s central heating and air-conditioning unit) may worsen asthma control; while dehumidifiers set to keep humidity levels lower than 50% may be beneficial in reducing asthma symptoms from house-dust mite exposure. Similar to the aforementioned avoidance measures for pollen-sensitive asthmatic individuals, asthma symptoms from exposure to mold spores may be minimized by staying indoors as much as possible (especially during peak spore concentrations) and keeping home and automobile windows closed. Other important outdoor asthma triggers include exposure to vehicle traffic (especially diesel exhaust), which might exacerbate preexisting allergic conditions by enhancing airway responses to allergen, a potential compounding effect. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152189/ doi: 10.1016/b978-032304289-5.10017-7 id: cord-016301-vqmqnipq author: Winnick, Aaron M. title: Elderly Transplant Recipients date: 2011-01-25 words: 11428.0 sentences: 504.0 pages: flesch: 40.0 cache: ./cache/cord-016301-vqmqnipq.txt txt: ./txt/cord-016301-vqmqnipq.txt summary: Current success in transplanting kidneys into older recipients has quieted misconceptions within medical communities and the general public, among them the erroneous belief that advanced age alone prevents a successful surgical outcome, that the elderly patient with ESRD has a very limited life expectancy, and thus cannot receive a transplant, and that older recipients have poor results based upon outdated information from the previous era of transplantation and immunosuppression. While ECD kidneys carry a relative risk of graft failure greater than 1.7 compared to a reference group of donors aged 10-39 years without any of the above three conditions, elderly recipients of ECD kidneys were found to have a survival benefit compared with waiting-list candidates (RR = 0.75; 95% CI 0.65-0.86; p < 0.0001) [8] . One study evaluated 91 transplant recipients over the age of 60 over a 13-year span and reported a 10-year patient survival of 35% in the elderly group and 60% in the younger patients ( p < 0.05). abstract: While the total number of organs transplanted in this country has increased over the years, there is still an ever-widening gap between the need for organs and our capacity to meet that need as the overall waiting list continues to grow. This is due in part to significant advances in transplant techniques and outcomes such that Americans with organ failure now seek transplants in greater numbers. Additionally, life-expectancy gains in the United States are creating an aging population who are more likely to suffer organ failure than younger Americans. The national transplant waiting list has continued to shift toward older candidates. The Scientific Registry of Transplant Recipients (SRTR) reported that at the end of 2007, 59.7% of all 97,248 candidates on the waiting list for all organs were 50 years old or older, and 14.9% were 65 years or older. These percentages are substantially higher than they were in 1998 (41.5 and 8.1%, respectively) [1]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120546/ doi: 10.1007/978-1-4419-6999-6_98 id: cord-013149-y0dbhtef author: Wohlfarth, P. title: Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date: 2020-10-12 words: 2333.0 sentences: 260.0 pages: flesch: 35.0 cache: ./cache/cord-013149-y0dbhtef.txt txt: ./txt/cord-013149-y0dbhtef.txt summary: Timing der Intensivstationsaufnahme Die vorhandenen Daten über kritisch kranke Krebspatienten mit den häufigsten Intensivstationsaufnahmegründen, ARV und Sepsis, zeigen einmütig, dass eine möglichst frühzeitige Verlegung auf die Intensivstation, also bei manifestem oder eventuell auch nur drohendem Organversagen, erfolgen sollte [8, 9] . Bei Patienten mit "chronic obstructive pulmonary disease" (COPD) und hypertensivem Lungenödem stellt die nichtinvasive Beatmung (NIV) den Goldstandard der Therapie dar und es gibt keine evidenzbasierte Rationale, dass dies nicht auch bei Krebspatienten gelten sollte. These include defining proper goals of intensive care treatment, managing acute respiratory failure with diverse differential considerations, treating immunologic side-effects of ever new and innovative cancer therapies, as well as numerous clinical scenarios which may exclusively arise in cancer patients. Cancer · Intensive care unit · Acute respiratory failure · Immunotherapy · iCHOP und womöglich "um jeden Preis" nicht zu intubieren, kann somit als überholt, ja im Fall sekundärerIntubationenbeiNIV-Versagen sogar als potenziell gefährlich angesehen werden. abstract: Intensivists are confronted with a broad spectrum of specific clinical problems while caring for critically ill cancer patients. These include defining proper goals of intensive care treatment, managing acute respiratory failure with diverse differential considerations, treating immunologic side-effects of ever new and innovative cancer therapies, as well as numerous clinical scenarios which may exclusively arise in cancer patients. To help clinicians handle such challenges, the initiative Intensive Care in Hematologic and Oncologic Patients (iCHOP) has been dealing with these topics for several years. Supported by several Austrian and German medical societies of intensive care medicine, hematology and oncology, the first “Consensus statement for cancer patients requiring intensive care support” has only recently been released. Acute respiratory failure and its management continues to be a major focus in critically ill cancer patients due to its frequency and its prognostic impact. While noninvasive oxygenation strategies were considered the gold standard of therapy, more recent high-quality data do not show clinical benefits of such techniques including high flow nasal oxygen. On the contrary, several studies revealed an unidentified etiology of an acute respiratory failure as the only potentially modifiable risk factor for adverse outcome. Consequently, evidence-based and rigorously applied diagnostic algorithms are of utmost importance in these patients. Furthermore, intensivists are increasingly confronted with the rising incidence of various and new immunotherapy-associated toxicities and their management. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549082/ doi: 10.1007/s00063-020-00737-5 id: cord-318021-4qrf5m8s author: Wolfensberger, A. title: Development and validation of a semi-automated surveillance system—lowering the fruit for non-ventilator-associated hospital-acquired pneumonia (nvHAP) prevention() date: 2019-03-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: Conducting manual surveillance of non-ventilator-associated hospital-acquired pneumonia (nvHAP) using ECDC (European Centre for Disease Prevention and Control) surveillance criteria is very resource intensive. We developed and validated a semi-automated surveillance system for nvHAP, and describe nvHAP incidence and aetiology at our hospital. METHODS: We applied an automated classification algorithm mirroring ECDC definition criteria to distinguish patients ‘not at risk’ from patients ‘at risk’ for suffering from nvHAP. ‘At risk’-patients were manually screened for nvHAP. For validation, we applied the reference standard of full manual evaluation to three validation samples comprising 2091 patients. RESULTS: Among the 39 519 University Hospital Zurich inpatient discharges in 2017, the algorithm identified 2454 ‘at-risk’ patients, reducing the number of medical records to be manually screened by 93.8%. From this subset, nvHAP was identified in 251 patients (0.64%, 95%CI: 0.57–0.73). Sensitivity, negative predictive value, and accuracy of semi-automated surveillance versus full manual surveillance were lowest in the validation sample consisting of patients with HAP according to the International Classification of Diseases (ICD-10) discharge diagnostic codes, with 97.5% (CI: 93.7–99.3%), 99.2% (CI: 97.9–99.8%), and 99.4% (CI: 98.4–99.8%), respectively. The overall incidence rate of nvHAP was 0.83/1000 patient days (95%CI: 0.73–0.94), with highest rates in haematology/oncology, cardiac and thoracic surgery, and internal medicine including subspecialties. CONCLUSIONS: The semi-automated surveillance demonstrated a very high sensitivity, negative predictive value, and accuracy. This approach significantly reduces manual surveillance workload, thus making continuous nvHAP surveillance feasible as a pivotal element for successful prevention efforts. url: https://api.elsevier.com/content/article/pii/S1198743X19301211 doi: 10.1016/j.cmi.2019.03.019 id: cord-027805-p0bhju1s author: Wong, An-Kwok Ian title: Consequences and Solutions for the Impact of Communication Impairment on Noninvasive Ventilation Therapy for Acute Respiratory Failure: A Focused Review date: 2020-06-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: With over 2 million cases of acute respiratory failure in the United States per year, noninvasive ventilation has become a leading treatment modality, often supplanting invasive mechanical ventilation as the initial treatment of choice. Most acute respiratory failure patients use a full face (oronasal) mask with noninvasive ventilation, which is known to impair communication, but its popularity and benefit has led many providers to accept the communication impairment. Medical staff periodically remove masks to communicate with patients, but patients are often limited to short utterances and risk lung derecruitment upon removal of positive pressure. These problems can lead to noninvasive ventilation failure, which is often linked to worse outcomes than first initiating invasive mechanical ventilation and can lead to increased hospitalization costs. DATA SOURCES: We searched MEDLINE and Google Scholar for “speech,” “communication,” “impairment,” “failure,” “complications,” “NIPPV,” “NIV,” and “noninvasive ventilation.” STUDY SELECTION: We included articles with patients in acute respiratory failure. We excluded articles for patients using noninvasive ventilation therapy for obstructive sleep apnea. DATA SYNTHESIS: Communication impairment has been associated with increasing noninvasive ventilation anxiety (odds ratio, 1.25). Of patients using noninvasive ventilation, 48% require early discontinuation, 22% refuse noninvasive ventilation, and 9% are ultimately intubated. Improvements to communication have been shown to reduce fear and anxiety in invasive mechanical ventilation patients. Analogous communication problems exist with effective solutions in other fields, such as fighter pilot masks, that can be easily implemented to enhance noninvasive ventilation patient care, increase adherence to noninvasive ventilation treatment, and improve patient outcomes. CONCLUSIONS: Communication impairment is an underappreciated cause of noninvasive ventilation complications and failure and requires further characterization. Analogous solutions—such as throat microphones and mask-based microphones—that can be easily implemented show potential as cost-effective methods to reduce noninvasive ventilation failure. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314319/ doi: 10.1097/cce.0000000000000121 id: cord-292952-z7ajsf2r author: Wong, Anselm title: COVID‐19 and toxicity from potential treatments: Panacea or poison date: 2020-05-12 words: 1425.0 sentences: 97.0 pages: flesch: 53.0 cache: ./cache/cord-292952-z7ajsf2r.txt txt: ./txt/cord-292952-z7ajsf2r.txt summary: One of the repercussions of promotion of medications/treatments prior to the results of large robust clinical trials being available is that people may start to self-medicate and potentially overdose. As emergency doctors, we need to be able to tease out the disease process of COVID-19 from potential side effects of trial medications or overdose of these. A small (n = 42), non-randomised open label trial showed decreased viral load in patients receiving hydroxychloroquine (600 mg daily for 10 days) and azithromycin. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected data to emulate a target trial Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial abstract: Since December 2019, coronavirus disease (COVID‐19) has been increasingly spreading from its origin in Wuhan, China to many countries around the world eventuating in morbidity and mortality affecting millions of people. This pandemic has proven to be a challenge given that there is no immediate cure, no vaccine is currently available and medications or treatments being used are still undergoing clinical trials. There have already been examples of self‐medication and overdose. Clearly, there is a need to further define the efficacy of treatments used in the management of COVID‐19. This evidence needs to be backed by large randomised‐controlled clinical trials. In the meantime, there will no doubt be further off‐label use of these medications by patients and practitioners and possibly related toxicity. url: https://www.ncbi.nlm.nih.gov/pubmed/32378805/ doi: 10.1111/1742-6723.13537 id: cord-313693-qmkrn7pr author: Wong, Bonnie C. K. title: Possible Role of Aerosol Transmission in a Hospital Outbreak of Influenza date: 2010-11-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. We examined the role of aerosol transmission of influenza in an acute ward setting. Methods. We investigated a seasonal influenza A outbreak that occurred in our general medical ward (with open bay ward layout) in 2008. Clinical and epidemiological information was collected in real time during the outbreak. Spatiotemporal analysis was performed to estimate the infection risk among patients. Airflow measurements were conducted, and concentrations of hypothetical virus-laden aerosols at different ward locations were estimated using computational fluid dynamics modeling. Results. Nine inpatients were infected with an identical strain of influenza A/H3N2 virus. With reference to the index patient's location, the attack rate was 20.0% and 22.2% in the “same” and “adjacent” bays, respectively, but 0% in the “distant” bay (P=.04). Temporally, the risk of being infected was highest on the day when noninvasive ventilation was used in the index patient; multivariate logistic regression revealed an odds ratio of 14.9 (95% confidence interval, 1.7–131.3; P=.015). A simultaneous, directional indoor airflow blown from the “same” bay toward the “adjacent” bay was found; it was inadvertently created by an unopposed air jet from a separate air purifier placed next to the index patient's bed. Computational fluid dynamics modeling revealed that the dispersal pattern of aerosols originated from the index patient coincided with the bed locations of affected patients. Conclusions. Our findings suggest a possible role of aerosol transmission of influenza in an acute ward setting. Source and engineering controls, such as avoiding aerosol generation and improving ventilation design, may warrant consideration to prevent nosocomial outbreaks. url: https://doi.org/10.1086/656743 doi: 10.1086/656743 id: cord-279483-gwikyux2 author: Wong, Joshua Guoxian title: Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department date: 2020-11-02 words: 4297.0 sentences: 247.0 pages: flesch: 43.0 cache: ./cache/cord-279483-gwikyux2.txt txt: ./txt/cord-279483-gwikyux2.txt summary: title: Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department We aim to provide an evidence-based clinical decision support tool for antibiotic prescribing using prediction models developed from local data. From 2009 to 2010, adults had the highest rate of inappropriate antibiotic use for acute respiratory tract infections (URTIs, influenza, and viral pneumonia), with 500 antibiotic prescriptions per 1000 ED visits for adults aged 20-64 years and 666 per 1000 visits for those aged > = 65 years [10] . In this study, we aim to develop prediction models based on local clinical and laboratory data to guide antibiotic prescribing for adult patients with uncomplicated URTI with the ultimate goal of deploying them as an evidencebased clinical decision support tool for routine practice. Antibiotic prescribing for patients with upper respiratory tract infections by emergency physicians in a Singapore tertiary hospital abstract: BACKGROUND: Appropriate antibiotic prescribing is key to combating antimicrobial resistance. Upper respiratory tract infections (URTIs) are common reasons for emergency department (ED) visits and antibiotic use. Differentiating between bacterial and viral infections is not straightforward. We aim to provide an evidence-based clinical decision support tool for antibiotic prescribing using prediction models developed from local data. METHODS: Seven hundred-fifteen patients with uncomplicated URTI were recruited and analysed from Singapore’s busiest ED, Tan Tock Seng Hospital, from June 2016 to November 2018. Confirmatory tests were performed using the multiplex polymerase chain reaction (PCR) test for respiratory viruses and point-of-care test for C-reactive protein. Demographic, clinical and laboratory data were extracted from the hospital electronic medical records. Seventy percent of the data was used for training and the remaining 30% was used for validation. Decision trees, LASSO and logistic regression models were built to predict when antibiotics were not needed. RESULTS: The median age of the cohort was 36 years old, with 61.2% being male. Temperature and pulse rate were significant factors in all 3 models. The area under the receiver operating curve (AUC) on the validation set for the models were similar. (LASSO: 0.70 [95% CI: 0.62–0.77], logistic regression: 0.72 [95% CI: 0.65–0.79], decision tree: 0.67 [95% CI: 0.59–0.74]). Combining the results from all models, 58.3% of study participants would not need antibiotics. CONCLUSION: The models can be easily deployed as a decision support tool to guide antibiotic prescribing in busy EDs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13756-020-00825-3. url: https://www.ncbi.nlm.nih.gov/pubmed/33138859/ doi: 10.1186/s13756-020-00825-3 id: cord-287210-sars5dmi author: Woo, Patrick C. Y. title: Clinical and Molecular Epidemiological Features of Coronavirus HKU1–Associated Community-Acquired Pneumonia date: 2005-12-01 words: 3345.0 sentences: 206.0 pages: flesch: 56.0 cache: ./cache/cord-287210-sars5dmi.txt txt: ./txt/cord-287210-sars5dmi.txt summary: However, the clinical and molecular epidemiological features of CoV-HKU1–associated pneumonia are unknown MethodsProspectively collected (during a 12-month period) nasopharyngeal aspirates (NPAs) from patients with community-acquired pneumonia from 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection of CoV-HKU1. All prospectively collected NPAs from patients with community-acquired pneumonia that were sent to the clinical microbiology laboratories of 4 hospitals in Hong Kong during a 12-month period (22 March 2003 [the beginning of the SARS epidemic in Hong Kong] to 21 March 2004) for detection of SARS-CoV and were found to be negative for SARS-CoV RNA, by reverse-transcription polymerase chain reaction (RT-PCR) [20] , were included in the study. Sequence analysis revealed 0%-2% nucleotide differences between the sequences of the fragments and the sequence of the pol gene from The epidemiological, clinical, and radiological characteristics of the 10 patients with CoV-HKU1-associated community-acquired pneumonia are summarized in table 2. abstract: BackgroundRecently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from a patient with pneumonia. However, the clinical and molecular epidemiological features of CoV-HKU1–associated pneumonia are unknown MethodsProspectively collected (during a 12-month period) nasopharyngeal aspirates (NPAs) from patients with community-acquired pneumonia from 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection of CoV-HKU1. The epidemiological, clinical, and laboratory characteristics of patients with CoV-HKU1–associated pneumonia were analyzed. The pol spike (S), and nucleocapsid (N) genes were also sequenced ResultsNPAs from 10 (2.4%) of 418 patients with community-acquired pneumonia were found to be positive for CoV-HKU1. All 10 cases occurred in spring and winter. Nine of these patients were adults, and 4 had underlying diseases of the respiratory tract. In the 6 patients from whom serum samples were available, all had a 4-fold change in immunoglobulin (Ig) G titer and/or presence of IgM against CoV-HKU1. The 2 patients who died had significantly lower hemoglobin levels, monocyte counts, albumin levels, and oxygen saturation levels on admission and had more-extensive involvement visible on chest radiographs. Sequence analysis of the pol S, and N genes revealed 2 genotypes of CoV-HKU1 ConclusionsCoV-HKU1 accounts for 2.4% of community-acquired pneumonia, with 2 genotypes in the study population. Without performance of diagnostic tests, the illness was clinically indistinguishable from other community-acquired pneumonia illnesses url: https://www.ncbi.nlm.nih.gov/pubmed/16267760/ doi: 10.1086/497151 id: cord-270712-v6nnnzhm author: Woodcock, J. A. title: Test, test, test! date: 2020-06-26 words: 1678.0 sentences: 101.0 pages: flesch: 60.0 cache: ./cache/cord-270712-v6nnnzhm.txt txt: ./txt/cord-270712-v6nnnzhm.txt summary: patients'' general medical practitioners (GMPs), funding restraints have resulted in NHS Clinical Commissioners advising against the routine prescription of high fluoride toothpaste in primary medical settings. For oncology patients without a regular GDP, or those who may have intermittent treatment in a tertiary dental centre, accessing prescriptions for high fluoride products may be particularly challenging during COVID-19. Sir, there are two reasons why the current guidelines pose an existential risk to dental practice: • The additional costs involved plus the required fallow periods make general practice dentistry unsustainable • The necessity to approach our patients while dressed like Darth Vader will raise perceived levels of fear and panic among them. It is important to reflect that we have always been an infection aware profession and have therefore often been at the forefront of infection control in the surgery for both our patients and the whole dental team. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32591677/ doi: 10.1038/s41415-020-1800-7 id: cord-021701-yan5q2r7 author: Woolard, Robert H. title: Emergency Department Design date: 2009-05-15 words: 4083.0 sentences: 272.0 pages: flesch: 50.0 cache: ./cache/cord-021701-yan5q2r7.txt txt: ./txt/cord-021701-yan5q2r7.txt summary: In the aftermath of recent terror events and subsequent disaster planning, hospital architects have begun to design EDs to better meet the needs anticipated from a terror attack. The technology needed to respond to a terrorist event, such as personal protective equipment (PPE), is becoming more widely available and is stored where easily available in EDs. Although mass decontamination can occur close to the disaster scene, EDs are gearing up to decontaminate, isolate, and treat individuals or groups contaminated with biologic or chemical materials. [8] [9] [10] [11] [12] Sensor technology is an area of active research that continues to yield new solutions that are being incorporated into EDs. In concept, all entrances could be designed to identify persons using scanning to detect unwanted chemicals,biologic agents,or explosives and to detain and decontaminate as needed. Overflow patients in hallways and adjacent spaces can be managed with mobile computing, which is available in many EDs. Wireless handheld devices can facilitate preparation for disasters and allow immediate access to information by providers in hallways and decontamination spaces. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151892/ doi: 10.1016/b978-0-323-03253-7.50074-1 id: cord-021721-80pp1ra4 author: Woolard, Robert H. title: Emergency Department Design date: 2015-10-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151923/ doi: 10.1016/b978-0-323-28665-7.00021-2 id: cord-266722-qfn2dc1q author: Wormser, Gary P. title: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date: 1987-06-30 words: 5482.0 sentences: 272.0 pages: flesch: 38.0 cache: ./cache/cord-266722-qfn2dc1q.txt txt: ./txt/cord-266722-qfn2dc1q.txt summary: Antibiotic therapy and menstruation can have a profound effect on the composition of this group of microorganisms.2 Disturbance of the delicate host-commensal relationship may cause a clinically significant infection due to these "nonpathogens." This may occur in response to the aforementioned factors (eg, pregnancy predisposing to vaginal candidiasis) or because of disruption of the anatomic barrier (eg, local mucosal infection at a site of trauma, or injury from cytotoxic drugs) or in association with exogenous infection (eg, rhinoviral infection leading to secondary bacterial otitis media). The skin lesions are tender and consist of papules and clear vesicles with a surrounding zone of erythema.617 Pharyngitis with tonsillar exudate persisting for 4 or more days with a negative throat culture for group A streptococci, or occurring in association with diffuse lymphadenopathy, splenomegaly or with many atypical lymphocytes on blood smear suggests the possibility of infectious mononucleosis (IM) (Epstein-Barr virus). abstract: Abstract The skin and mucous membranes are the principal barriers to invasion of the body by microorganisms. Besides functioning as a mechanical barrier, the mucosae are endowed with an array of still poorly characterized specific and nonspecific host defense capabilities. These include the production of mucus, secretory immunoglobulin (IgA), lysozyme, lactoferrin, and alpha-antitrypsin, in conjunction with a low-grade exudation of leukocytes.1 In addition, the mucosal surfaces of the upper respiratory, gastrointestinal, and lower vaginal and urinary tracts support a large number of “nonpathogenic” microorganisms that comprise the so-called “normal flora.” This commensal flora plays an important and complex role in protecting the host from microbial invasion. Mechanisms for this protection likely include the following: (1) competition for the same nutrients (interference); (2) competition for the same receptors on host cells (tropism); (3) production of bacteriocins, that is, bacterial products that are toxic to other organisms, usually of the same species; and (4) stimulation of crossprotective immune factors such as the “natural antibodies.”1 The “normal” flora is inconstant and may be altered by dietary factors, debilitation, hormonal events (such as menstruation, pregnancy, and possibly use of oral contraceptives), personal hygiene, medications, intercurrent infection, and probably many others. Antibiotic therapy and menstruation can have a profound effect on the composition of this group of microorganisms.2 Disturbance of the delicate host-commensal relationship may cause a clinically significant infection due to these “nonpathogens.” This may occur in response to the aforementioned factors (eg, pregnancy predisposing to vaginal candidiasis) or because of disruption of the anatomic barrier (eg, local mucosal infection at a site of trauma, or injury from cytotoxic drugs) or in association with exogenous infection (eg, rhinoviral infection leading to secondary bacterial otitis media). Invasion by “normal flora” may result in serious systemic illness. A clear example of the latter is the development of infective endocarditis caused by viridans streptococci following a dental procedure. url: https://api.elsevier.com/content/article/pii/0738081X87900137 doi: 10.1016/0738-081x(87)90013-7 id: cord-285897-ahysay2l author: Wu, Guangyao title: Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study date: 2020-07-02 words: 3803.0 sentences: 178.0 pages: flesch: 42.0 cache: ./cache/cord-285897-ahysay2l.txt txt: ./txt/cord-285897-ahysay2l.txt summary: OBJECTIVE: To develop and validate machine-learning model based on clinical features for severity risk assessment and triage for COVID-19 patients at hospital admission. CONCLUSION: The machine-learning model, nomogram, and online-calculator might be useful to access the onset of severe and critical illness among COVID-19 patients and triage at hospital admission. Therefore, our objective is to develop and validate a prognostic machine-learning model based on clinical, laboratory, and radiological variables of COVID-19 patients at hospital admission for severity risk assessment during hospitalization, and compare the performance with that of PSI as a representative clinical assessment method. This international multicenter study analyzed individually and in combination, clinical, laboratory and radiological characteristics for COVID-19 patients at hospital admission, to retrospectively develop and prospectively validate a prognostic model and tool to assess the severity of the illness, and its progression, and to compare these with PSI scoring. abstract: BACKGROUND: The outbreak of the coronavirus disease 2019 (COVID-19) has globally strained medical resources and caused significant mortality. OBJECTIVE: To develop and validate machine-learning model based on clinical features for severity risk assessment and triage for COVID-19 patients at hospital admission. METHOD: 725 patients were used to train and validate the model including a retrospective cohort of 299 hospitalised COVID-19 patients at Wuhan, China, from December 23, 2019, to February 13, 2020, and five cohorts with 426 patients from eight centers in China, Italy, and Belgium, from February 20, 2020, to March 21, 2020. The main outcome was the onset of severe or critical illness during hospitalisation. Model performances were quantified using the area under the receiver operating characteristic curve (AUC) and metrics derived from the confusion-matrix. RESULTS: The median age was 50.0 years and 137 (45.8%) were men in the retrospective cohort. The median age was 62.0 years and 236 (55.4%) were men in five cohorts. The model was prospectively validated on five cohorts yielding AUCs ranging from 0.84 to 0.89, with accuracies ranging from 74.4% to 87.5%, sensitivities ranging from 75.0% to 96.9%, and specificities ranging from 57.5% to 88.0%, all of which performed better than the pneumonia severity index. The cut-off values of the low, medium, and high-risk probabilities were 0.21 and 0.80. The online-calculators can be found at www.covid19risk.ai. CONCLUSION: The machine-learning model, nomogram, and online-calculator might be useful to access the onset of severe and critical illness among COVID-19 patients and triage at hospital admission. url: https://www.ncbi.nlm.nih.gov/pubmed/32616597/ doi: 10.1183/13993003.01104-2020 id: cord-014833-ax09x6gk author: Wu, Jia title: Data Decision and Transmission Based on Mobile Data Health Records on Sensor Devices in Wireless Networks date: 2016-06-20 words: 4029.0 sentences: 293.0 pages: flesch: 61.0 cache: ./cache/cord-014833-ax09x6gk.txt txt: ./txt/cord-014833-ax09x6gk.txt summary: title: Data Decision and Transmission Based on Mobile Data Health Records on Sensor Devices in Wireless Networks History data, collection data, and doctor-analyzed data could be computed and transmitted to patients using sensor devices. This study establishes a new method that can decide and transmit effective data based on sensor device mobile health in wireless networks. This study establishes a new method that can decide and transmit effective data based on sensor device mobile health in wireless networks. According to an established mobile health system, patients can obtain timely treatment from doctors or hospitals by using wireless sensor devices. In mobile health, sensor devices and mobile device are the cheapest and most convenient means of data collection and transmission among doctors, patients, and hospitals. Formula (8) assumes that a ¼ 0:15; b ¼ 0:35; c ¼ 0:5: Sensor devices may calculate the probability and transmit diagnosis data to the mobile APP to be evaluated by patients and doctors. abstract: The contradiction between a large population and limited and unevenly distributed medical resources is a serious problem in many developing countries. This problem not only affects human health but also leads to the occurrence of serious infection if treatment is delayed. With the development of wireless communication network technology, patients can acquire real-time medical information through wireless network equipment. Patients can have the opportunity to obtain timely medical treatment, which may alleviate the shortage of medical resources in developing countries. This study establishes a new method that can decide and transmit effective data based on sensor device mobile health in wireless networks. History data, collection data, and doctor-analyzed data could be computed and transmitted to patients using sensor devices. According to probability analysis, patients and doctors may confirm the possibility of certain diseases. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088664/ doi: 10.1007/s11277-016-3438-y id: cord-308390-ei96iuw3 author: Wu, Junping title: Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy date: 2020-11-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We report a case series of ozonated autohemotherapy of four COVID-19 patients, classified as critically ill (1 patient), severe (1 patient), and moderate (2 patients). Each ozonated autohemotherapy treatment was performed at a concentration of 40 μg/ml of ozone per 100 ml of blood. The number of treatments varied from 1 to 9 depending on the disease severity. All 4 patients, including 1 critically ill patient with severe acute respiratory distress syndrome (ARDS) and life-threatening refractory hypoxemia, recovered uneventfully and were discharged from the hospital after viral clearance. The younger sibling of the critically ill patient was also diagnosed with COVID-19 and developed ARDS with hypoxemia, who received mechanical ventilation through an endotracheal tube and extracorporeal membrane oxygenation (ECMO) support. The overall medical cost for 18 days spent in the intensive care unit (ICU) and 56 days of hospitalization was $139,935 USD. On the other hand, our critically ill patient underwent 9 ozonated autohemotherapy treatments and spent 10 days in the ICU and was discharged on hospital day 30; his hospitalization cost amounted to $15,466.50 USD. This case series suggests that ozonated autohemotherapy may be an alternative noninvasive medical treatment for COVID-19 patients. url: https://doi.org/10.1016/j.xinn.2020.100060 doi: 10.1016/j.xinn.2020.100060 id: cord-282219-7kzbnymp author: Wu, Liu title: The effect of massage on the quality of life in patients recovering from COVID-19: A systematic review protocol date: 2020-06-05 words: 2455.0 sentences: 167.0 pages: flesch: 50.0 cache: ./cache/cord-282219-7kzbnymp.txt txt: ./txt/cord-282219-7kzbnymp.txt summary: title: The effect of massage on the quality of life in patients recovering from COVID-19: A systematic review protocol Secondary outcomes were accompanying symptoms (such as myalgia, expectoration, stuffiness, runny nose, pharyngalgia, anhelation, chest distress, dyspnea, crackles, headache, nausea, vomiting, anorexia, diarrhea) disappear rate, negative COVID-19 results rate on 2 consecutive occasions (not on the same day), average hospitalization time, clinical curative effect, and improved quality of life. CONCLUSION: The conclusion of our study will provide evidence to judge whether massage is an effective intervention on the quality of life in patients recovering. [6] Coronaviruses (CoVs), mainly targeting human respiratory system, are responsible for health-threatening outbreaks including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome, and lastly coronavirus disease 2019 (COVID-19). We will include articles related to massage therapy of patients recovering from COVID-19. This article will use the evidence quality rating method to evaluate the results obtained from this analysis. abstract: BACKGROUND: There is a worldwide outbreak of covid-19, and as the number of patients increases, more and more patients are recovering. Massage is used as an alternative therapy. Currently, there are no relevant articles for systematic review. METHODS: We will search the randomized controlled trials related to acupuncture therapy and postoperative anorectal diseases from inception to January 2020. The following database is our focus area: the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wan-Fang Database. All published randomized controlled trials in English or Chinese related to massage for COVID-19 will be included. Primary outcome asthe influence of massage on the quality of life of convalescent patients. Secondary outcomes were accompanying symptoms (such as myalgia, expectoration, stuffiness, runny nose, pharyngalgia, anhelation, chest distress, dyspnea, crackles, headache, nausea, vomiting, anorexia, diarrhea) disappear rate, negative COVID-19 results rate on 2 consecutive occasions (not on the same day), average hospitalization time, clinical curative effect, and improved quality of life. RESULTS: The results will provide a high-quality synthesis of current evidence for researchers in this subject area. CONCLUSION: The conclusion of our study will provide evidence to judge whether massage is an effective intervention on the quality of life in patients recovering. PROSPERO REGISTRATION NUMBER: CRD42020181398 url: https://www.ncbi.nlm.nih.gov/pubmed/32502008/ doi: 10.1097/md.0000000000020529 id: cord-356379-e8ohc25w author: Wu, Qiuji title: Recovery from COVID‐19 in two patients with coexisted HIV infection date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: COVID‐19 has become a global health concern. HIV‐infected patients are particularly vulnerable to COVID‐19 due to their immune‐compromised status. The clinical manifestations and clinical outcomes of these patients are not clear. In this report, we presented two special COVID‐19 patients with HIV infection and other comorbidities. We described the clinical characteristics, clinical manifestations, treatments and clinical outcomes of both patients. One patient with prior HIV‐infection continued anti‐HIV treatment when diagnosed with COVID‐19. The other patient was newly diagnosed with HIV‐infection when diagnosed with COVID‐19 and had not begun anti‐HIV treatment. Both patients were treated with anti‐viral, antibiotics, oxygen treatment and supportive care and recovered from severe pneumonia. The experience of these two cases suggested that COVID‐19 patients with HIV infection could still have satisfactory clinical outcomes following proper medical care. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/jmv.26006 doi: 10.1002/jmv.26006 id: cord-354824-7fdcu2f0 author: Wu, Renyi title: An Update on Current Therapeutic Drugs Treating COVID-19 date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. These drugs and therapeutic agents include antiviral agents (remdesivir, hydroxychloroquine, chloroquine, lopinavir, umifenovir, favipiravir, and oseltamivir), and supporting agents (Ascorbic acid, Azithromycin, Corticosteroids, Nitric oxide, IL-6 antagonists), among others. We hope that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2. url: https://doi.org/10.1007/s40495-020-00216-7 doi: 10.1007/s40495-020-00216-7 id: cord-011296-nutl2ovk author: Wu, Venus Kit Sze title: Prevalence, Clinical Characteristics, and Outcomes Related to Ventilator-Associated Events in Neurocritically Ill Patients date: 2020-01-23 words: 3569.0 sentences: 174.0 pages: flesch: 38.0 cache: ./cache/cord-011296-nutl2ovk.txt txt: ./txt/cord-011296-nutl2ovk.txt summary: BACKGROUND: The prevalence, characteristics, and outcomes related to the ventilator-associated event(s) (VAE) in neurocritically ill patients are unknown and examined in this study. METHODS: A retrospective study was performed on neurocritically ill patients at a 413-bed level 1 trauma and stroke center who received three or more days of mechanical ventilation to describe rates of VAE, describe characteristics of patients with VAE, and examine the association of VAE on ventilator days, mortality, length of stay, and discharge to home. The main findings of this study are that (1) VAEs are prevalent among neurocritically ill patients, occur within the first week of mechanical ventilation, across age, sex, BMI, and GCS, and the rates differ among various diagnoses, (2) the most common trigger for VAE is an increase in PEEP, and (3) VAE is associated with increased time spent on mechanical ventilation but is not associated with increased in-hospital mortality or discharge to home. abstract: BACKGROUND: The prevalence, characteristics, and outcomes related to the ventilator-associated event(s) (VAE) in neurocritically ill patients are unknown and examined in this study. METHODS: A retrospective study was performed on neurocritically ill patients at a 413-bed level 1 trauma and stroke center who received three or more days of mechanical ventilation to describe rates of VAE, describe characteristics of patients with VAE, and examine the association of VAE on ventilator days, mortality, length of stay, and discharge to home. RESULTS: Over a 5-year period from 2014 through 2018, 855 neurocritically ill patients requiring mechanical ventilation were identified. A total of 147 VAEs occurred in 130 (15.2%) patients with an overall VAE rate of 13 per 1000 ventilator days and occurred across age, sex, BMI, and admission Glasgow Coma Scores. The average time from the start of ventilation to a VAE was 5 (range 3–48) days after initiation of mechanical ventilation. Using Centers for Disease Control and Prevention definitions, VAEs met criteria for a ventilator-associated condition in 58% of events (n = 85), infection-related VAE in 22% of events (n = 33), and possible ventilator-associated pneumonia in 20% of events (n = 29). A most common trigger for VAE was an increase in positive end-expiratory pressure (84%). Presence of a VAE was associated with an increase in duration of mechanical ventilation (17.4[IQR 20.5] vs. 7.9[8.9] days, p < 0.001, 95% CI 7.86–13.92), intensive care unit (ICU) length of stay (20.2[1.1] vs. 12.5[0.4] days, p < 0.001 95% CI 5.3–10.02), but not associated with in-patient mortality (34.1 vs. 31.3%. 95% CI 0.76–1.69) or discharge to home (12.7% vs. 16.3%, 95% 0.47–1.29). CONCLUSIONS: VAE are prevalent in the neurocritically ill. They result in an increased duration of mechanical ventilation and ICU length of stay, but may not be associated with in-hospital mortality or discharge to home. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12028-019-00910-5) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223985/ doi: 10.1007/s12028-019-00910-5 id: cord-315486-pjb5v1tc author: Wu, Xiaojun title: Different Laboratory Abnormalities in COVID-19 Patients with Hypertension or Diabetes date: 2020-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s12250-020-00296-1 doi: 10.1007/s12250-020-00296-1 id: cord-272677-6t9kl3hq author: Wu, w. title: Key Points of Clinical and CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) Imported Pneumonia Based On 21 Cases Analysis date: 2020-03-06 words: 4067.0 sentences: 269.0 pages: flesch: 56.0 cache: ./cache/cord-272677-6t9kl3hq.txt txt: ./txt/cord-272677-6t9kl3hq.txt summary: Conclusions: Fever and cough are the typical clinical features of NCP patients, and chest CT mainly manifested as multiple lesions in both lungs, often accompanied by GGO, vascular enlargement and cobblestone/reticular pattern.Changes in these main CT features can indicate development of the disease. Conclusions: Fever and cough are the typical clinical features of NCP patients, and chest CT mainly manifested as multiple lesions in both lungs, often accompanied by GGO, vascular enlargement and cobblestone/reticular pattern.Changes in these main CT features can indicate development of the disease Keywords: 2019-nCov; New coronavirus pneumonia; Chest CT; Ground glass opacification Based on the clinical observations and summary, the main diagnostic criteria [6] of 2019-nCov infections are : 1) Contact history of the epidemic area and related patients; 2) Nucleic acid is positive; 3) Fever, cough, shortness of breath and other clinical symptoms; 4) Laboratory examination showed that white blood cells were normal or decreased and lymphocytes decreased; 5) Lung lesions. abstract: Background and Objective: WHO Director-General declared that the 2019-nCoV outbreak constitutes a Public Health Emergency of International Concern,and the outbreak is still on-going.Chest CT had been a key component of the diagnostic workup for patients with suspected infection. In this retrospective study, we attempt to summarize and analyze the chest CT features of 2019-nCov infections, and to identify the typical features to improved the diagnostic accuracy of new coronavirus pneumonia (NCP). Methods:Chest CT scans and Clinical data of 21 patients confirmed NCP in our hospital were enrolled.These patients were divided into mild and sever group according to clinical manifestations described by the 6th clinical practice guideline of NCP in China. Main clinical and chest CT features were analyzed and identify. Results: Fever (85.7%) and cough (80.9%) were the two main symptoms of NCP patients.More significantly higher incidence (85.7%) of shortness of breath in the severe cases. Multiple lesions in both lungs and with incidence of GGO(100%),vascular enlargement (76.5%) and cobblestone/reticular pattern(70.6%) were the major feature.The incidence of consolidation, mixed pattern and vascular enlargement features were up to 100% in the severe group, significantly higher than that of patients in mild group. In addition, the incidence of air-bronchogram, dilated bronchi with thickened wall and fibrosis in the severe group was significantly higher than that in the mild group. Conclusions: Fever and cough are the typical clinical features of NCP patients, and chest CT mainly manifested as multiple lesions in both lungs, often accompanied by GGO, vascular enlargement and cobblestone/reticular pattern.Changes in these main CT features can indicate development of the disease. url: https://doi.org/10.1101/2020.03.03.20030775 doi: 10.1101/2020.03.03.20030775 id: cord-272071-445ivhx0 author: Wunsch, Hannah title: Mechanical Ventilation in COVID-19: Interpreting the Current Epidemiology date: 2020-07-01 words: 2632.0 sentences: 124.0 pages: flesch: 47.0 cache: ./cache/cord-272071-445ivhx0.txt txt: ./txt/cord-272071-445ivhx0.txt summary: What we are seeing in the current publications on COVID-19 are different rates of invasive mechanical ventilation across the world that have always existed, but these differences are now writ large because it is a particularly high-stakes game of worldwide data interpretation and a desperation to learn as much as possible from the experiences of others. This variability in preferences is intertwined with resources and always will be a huge factor in understanding the data coming out of different countries; for example, in 2008, Gray and colleagues published a large randomized controlled trial comparing noninvasive ventilation to conventional oxygen therapy for patients with acute cardiogenic pulmonary edema. Similarly, information on care preferences, such as how many patients preferred not to receive mechanical ventilation (because of age, comorbidity, or other personal preference) would aid in interpreting data, such as when reporting that only 20.2% of those who died with COVID-19 received this intervention (12) . abstract: nan url: https://doi.org/10.1164/rccm.202004-1385ed doi: 10.1164/rccm.202004-1385ed id: cord-304399-7t2mu13s author: Wynne, Keona Jeane title: Dying individuals and suffering populations: applying a population-level bioethics lens to palliative care in humanitarian contexts: before, during and after the COVID-19 pandemic date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Humanitarian crises and emergencies, events often marked by high mortality, have until recently excluded palliative care—a specialty focusing on supporting people with serious or terminal illness or those nearing death. In the COVID-19 pandemic, palliative care has received unprecedented levels of societal attention. Unfortunately, this has not been enough to prevent patients dying alone, relatives not being able to say goodbye and palliative care being used instead of intensive care due to resource limitations. Yet global guidance was available. In 2018, the WHO released a guide on ‘Integrating palliative care and symptom relief into the response to humanitarian emergencies and crises’—the first guidance on the topic by an international body. AIMS: This paper argues that while a landmark document, the WHO guide took a narrowly clinical bioethics perspective and missed crucial moral dilemmas. We argue for adding a population-level bioethics lens, which draws forth complex moral dilemmas arising from the fact that groups having differential innate and acquired resources in the context of social and historical determinants of health. We discuss dilemmas concerning: limitations of material and human resources; patient prioritisation; euthanasia; and legacy inequalities, discrimination and power imbalances. IMPLICATIONS: In parts of the world where opportunity for preparation still exists, and as countries emerge from COVID-19, planners must consider care for the dying. Immediate steps to support better resolutions to ethical dilemmas of the provision of palliative care in humanitarian and emergency contexts will require honest debate; concerted research effort; and international, national and local ethical guidance. url: https://doi.org/10.1136/medethics-2019-105943 doi: 10.1136/medethics-2019-105943 id: cord-328814-s3963anw author: XU, Jing title: Exploration on the feasibility of moxibustion in prevention and treatment of COVID-19 from the perspective of modern medical mechanism date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Novel coronavirus pneumonia (COVID-19) is rampant in many countries and regions and there is no time to delay the exploration of the scheme for its prevention and control. The pathogenic characteristics of novel coronavirus and the effect of moxibustion for warming up yang and strengthening the antipathogenic qi were analyzed in this paper. From the perspective of modern medical mechanism, during the prevention and treatment of novel coronaviral infection, moxibustion may be able to prevent and treat COVID-19 by improving the body's immunity so as to conquer virus, by anti-inflammation to alleviate the inflammatory response of COVID-19 and by improving lung function to inhibit pulmonary fibrosis. url: https://doi.org/10.1016/j.wjam.2020.06.001 doi: 10.1016/j.wjam.2020.06.001 id: cord-353228-fxrf5wsp author: Xiao, Yaru title: Clinical characteristics of diarrhea in 90 cases with COVID-19: a descriptive study date: 2020-08-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The novel coronavirus disease (COVID-19) has spread worldwide. Herein, we aimed to clarify the epidemiological and clinical characteristics of patients presenting with diarrhea. METHODS: A descriptive design was adopted from Jan 10 to Feb 17, 2020. All the cases included were diagnosed with COVID-19 under the interim guidance of the WHO. RESULTS: 912 patients with COVID-19 were admitted to hospital, in which, 90 cases (9.87％) presented with diarrhea. Among the 90 cases, 8 cases (9％) presented with diarrhea as the initial symptom, and 24%, 17%, and 24% of the patients complained of nausea, vomiting, and poor appetite, respectively. The most common fecal characteristics on admission were watery stool (64%) and mushy stool (28%). For the defecation frequency, 37% of the cases defecated over three times a day. The median time from illness onset to diarrhea was 3.0 days (IQR 0.0-5.0) and the median duration of diarrhea was 5.0 days (IQR 2.0-9.3). CONCLUSION: Clinicians are required to promptly identify the patients with initial diarrhea symptoms and pay adequate attention to the nutrient requirements of the patients with diarrhea during hospitalization. Standardized management is also recommended for the discharge of the patients to avoid potential fecal-oral transmission. url: https://doi.org/10.1016/j.ienj.2020.100912 doi: 10.1016/j.ienj.2020.100912 id: cord-333749-45v6b4tc author: Xie, Guogang title: The role of peripheral blood eosinophil counts in COVID‐19 patients date: 2020-06-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID‐19) emerged in Wuhan city and rapidly spread globally outside China. We aimed to investigate the role of peripheral blood eosinophil (EOS) as a marker in the course of the virus infection to improve the efficiency of diagnosis and evaluation of COVID‐19 patients. METHODS: 227 pneumonia patients who visited the fever clinics in Shanghai General Hospital and 97 hospitalized COVID‐19 patients admitted to Shanghai Public Health Clinical Center were involved in a retrospective research study. Clinical, laboratory, and radiologic data were collected. The trend of EOS level in COVID‐19 patients and comparison among patients with different severity were summarized. RESULTS: The majority of COVID‐19 patients (71.7%) had a decrease in circulating EOS counts, which was significantly more frequent than other types of pneumonia patients. EOS counts had good value for COVID‐19 prediction, even higher when combined with NLR. Patients with low EOS counts at admission were more likely to have fever, fatigue and shortness of breath, with more lesions in chest CT and radiographic aggravation, longer length of hospital stay and course of disease than those with normal EOS counts. Circulating EOS level gradually increased over the time, and was synchronous with the improvement of chest CT(12days vs 13days, P=0.07), later than that of body temperature(12days vs 10days, P=0.014), but was earlier than the negative conversion of nucleic acid assays(12days vs 17days, P=0.001). CONCLUSION: Peripheral blood EOS counts may be an effective and efficient indicator in diagnosis, evaluation and prognosis monitoring of COVID‐19 patients. url: https://doi.org/10.1111/all.14465 doi: 10.1111/all.14465 id: cord-343876-2inr4mcy author: Xie, Qin title: COVID-19 patients managed in psychiatric inpatient settings due to first-episode mental disorders in Wuhan, China: clinical characteristics, treatments, outcomes, and our experiences date: 2020-10-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Data are scarce regarding the comorbid mental disorders and their management among COVID-19 patients. This study described the clinical characteristics and management of COVID-19 patients treated in psychiatric inpatient settings due to comorbid first-onset mental disorders in Wuhan, China. This electronic medical records-based study included 25 COVID-19 patients with first-onset mental disorders and 55 patients with first-onset mental disorders without COVID-19 (control group). Data collected included ICD-10 diagnoses of mental disorders, psychiatric and respiratory symptoms, treatments, and outcomes. Adjustment disorder (n = 11, 44.0%) and acute and transient psychotic disorders, with associated acute stress (n = 6, 24.0%) were main clinical diagnoses in the COVID-19 group while serious mental illnesses (i.e., schizophrenia, 24.5%) and alcohol use disorders (10.9%) were overrepresented in the control group. On admission, the most common psychiatric symptom in COVID-19 patients was insomnia symptoms (n = 18, 72.0%), followed by aggressive behaviors (n = 16, 64.0%), delusion (n = 10, 40.0%), and severe anxiety (n = 9, 36.0%). In addition to respiratory treatments, 76.0% COVID-19 patients received antipsychotics, 40.0% sedative-hypnotics, and 24.0% mood stabilizers. At the end of inpatient treatment, 4 (16.0%) COVID-19 patients were transferred to other hospitals to continue respiratory treatment after their psychiatric symptoms were controlled while the remaining 21 (84.0%) all recovered. Compared to the control group, COVID-19 group had significantly shorter length of hospital stay (21.2 vs. 37.4 days, P < 0.001). Adjustment disorder and acute and transient psychotic disorders are the main clinical diagnoses of COVID-19 patients managed in psychiatric inpatient settings. The short-term prognosis of these patients is good after conventional psychotropic treatment. url: https://www.ncbi.nlm.nih.gov/pubmed/33009366/ doi: 10.1038/s41398-020-01022-x id: cord-315056-ohyb6oa0 author: Xu, Juanjuan title: Clinical characteristics and outcomes of severe or critical COVID-19 patients presenting no respiratory symptoms or fever at onset date: 2020-10-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: It is difficult to identify suspected cases of atypical patients with coronavirus disease 2019 (COVID-19), and data on severe or critical patients are scanty. This retrospective study presents the clinical, laboratory, and radiological profiles, treatments, and outcomes of atypical COVID-19 patients without respiratory symptoms or fever at onset. The study examined ten atypical patients out of 909 severe or critical patients diagnosed with COVID-19 in Wuhan Union Hospital West Campus between 25 January 2020 and 10 February 2020. Data were obtained from the electronic medical records of severe or critical patients without respiratory symptoms or fever at onset. Outcomes were followed up to discharge or death. Among 943 COVID-19 patients, 909 (96.4%) were severe or critical type. Of the severe or critical patients, ten (1.1%) presented without respiratory symptoms or fever at admission. The median age of the ten participants was 63 years (interquartile range (IQR): 57–72), and seven participants were men. The median time from symptom onset to admission was 14 d (IQR: 7–20). Eight of the ten patients had chronic diseases. The patients had fatigue (n = 5), headache or dizziness (n = 4), diarrhea (n = 5), anorexia (n = 3), nausea or vomiting (n = 3), and eye discomfort (n = 1). Four patients were found to have lymphopenia. Imaging examination revealed that nine patients had bilateral pneumonia and one had unilateral pneumonia. Eventually, two patients died and eight were discharged. In the discharged patients, the median time from admission to discharge lasted 24 d (IQR: 13–43). In summary, some severe or critical COVID-19 patients were found to have no respiratory symptoms or fever at onset. All such atypical cases should be identified and quarantined as early as possible, since they tend to have a prolonged hospital stay or fatal outcomes. Chest computed tomography (CT) scan and nucleic acid detection should be performed immediately on close contacts of COVID-19 patients to screen out those with atypical infections, even if the contacts present without respiratory symptoms or fever at onset. url: https://www.ncbi.nlm.nih.gov/pubmed/33163252/ doi: 10.1016/j.eng.2020.09.009 id: cord-266775-4npowkkz author: Xu, Jun title: Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis date: 2005-10-15 words: 3449.0 sentences: 167.0 pages: flesch: 46.0 cache: ./cache/cord-266775-4npowkkz.txt txt: ./txt/cord-266775-4npowkkz.txt summary: In the present study, we isolated a SARS coronavirus strain from a brain tissue specimen obtained from a patient with SARS with significant central nervous symptoms. In the present study, we isolated a SARS-CoV strain from a brain tissue specimen obtained during autopsy from a patient with SARS who became severely sick and showed significant central nervous symptoms during the course of his illness. Immunohistochemistry stains for N protein of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in a specimen of brain tissue obtained from the patient with SARS during autopsy. With regard to the superinfection with invasive Aspergillus in the brain and other organs of the patient, we think that severe immunodepression resulting from the damage to the immune system induced by SARS-CoV infection, combined with high-dosage treatment with a corticosteroid, provided access for conditional pathogens, causing a superinfection with invasive Aspergillus in multiple organs [24] . abstract: Background. Previous studies have shown that common human coronavirus might be neurotropic, although it was first isolated as a pathogen of the respiratory tract. We noticed that a few patients with severe acute respiratory syndrome (SARS) experienced central nervous symptoms during the course of illness. In the present study, we isolated a SARS coronavirus strain from a brain tissue specimen obtained from a patient with SARS with significant central nervous symptoms. Methods. Using transmission electronic microscopy and nested reverse transcription–polymerase chain reaction, the causative pathogen was identified in cultures of a brain tissue specimen obtained from the patient with SARS. Histopathologic examination of the brain tissue was performed using the methods of immunohistochemistry analysis and double immunofluorescence staining. Fifteen cytokines and chemokines were detected in the blood of the patient with SARS by means of a bead-based multiassay system. Results. A fragment specific for SARS human coronavirus was amplified from cultures of the brain suspension, and transmission electronic microscopy revealed the presence of an enveloped virus morphologically compatible with a coronavirus isolated in the cultures. Pathologic examination of the brain tissue revealed necrosis of neuron cells and broad hyperplasia of gliocytes. Immunostaining demonstrated that monokine induced by interferon-Γ (Mig) was expressed in gliocytes with the infiltration of CD68(+) monocytes/macrophages and CD3(+) T lymphocytes in the brain mesenchyme. Cytokine/chemokine assay revealed that levels of interferon-Γ–inducible protein 10 and Mig in the blood were highly elevated, although the levels of other cytokines and chemokines were close to normal. Conclusions. This study provides direct evidence that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS. url: https://www.ncbi.nlm.nih.gov/pubmed/16163626/ doi: 10.1086/444461 id: cord-324880-s1oqkqef author: Xu, Lili title: A fatal case associated with respiratory syncytial virus infection in a young child date: 2018-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. Risk factors for high mortality and prolonged morbidity after RSV infection include premature birth, bronchopulmonary dysplasia, congenital heart disease, and Down syndrome. However, some previously healthy, full-term children who are infected with RSV also require hospitalization and even experience severe sequelae or death. CASE PRESENTATION: In this report, we present the case of an RSV-associated death of a child who was born at full-term and developed normally up to the age of 2 years old. Cardiopulmonary arrest occurred within 3 days after the onset of symptoms, which included cough and high fever. Complete brain edema was prominent, and encephalopathy was developing. Viral antigen detection and microbiome analyses of oral swab and nasopharyngeal aspirate specimens verified an RSV infection, while bacterial culture of blood specimens yielded negative results. The RSV strain detected in this patient was subtyped as RSVB9, and no mutation was found in the six antigenic sites for targeted drugs or vaccines. CONCLUSIONS: The patient had a severe infection associated with RSV, which was very likely the cause of her central nervous system infection and acute neurological complications. url: https://www.ncbi.nlm.nih.gov/pubmed/29751747/ doi: 10.1186/s12879-018-3123-8 id: cord-271212-y8denvju author: Xu, Xia title: Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China date: 2020-07-25 words: 3097.0 sentences: 165.0 pages: flesch: 52.0 cache: ./cache/cord-271212-y8denvju.txt txt: ./txt/cord-271212-y8denvju.txt summary: title: Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. From February 3, 2020, to March 20, 2020, we conducted a retrospective study focusing on the clinical characteristics of confirmed cases of COVID-19 in Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, during which the rapid growth speed of diagnosis rated up to 58% in Wuhan, Hubei province. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China abstract: Background and aim: The outbreak of coronavirus disease 2019 (COVID-19) is quickly turning into a pandemic. We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity. Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. Results: 88 hospitalization patients confirmed COVID-19 were enrolled in this study. The average age of the patients was 57.11 years (SD, ±15.39). Of these 88 patients, the median body mass index (BMI) was 24.03 (IQR, 21.64-26.61; range 15.05-32.39), the median duration from disease onset to hospital admission were 11 days (IQR, 6.50-14.50). 46.59% patients had one or more comorbidities, with hypertension being the most common (26.14%), followed by diabetes mellitus (12.50%) and coronary atherosclerotic heart disease (CAD) (7.95%). Common symptoms at onset of disease were fever (71.59%), cough (59.09%), dyspnea (38.64%) and fatigue (29.55%). 88 patients were divided into moderate (47 [53.41%]), severe (32 [36.36%]) and critically ill (9 [10.23%]) groups. Compared with severe and moderate patients, lymphocytopenia occurred in 85.71% critically ill patients, and serum IL-2R, IL-6, IL-8, TNF-α, LDH, and cTnI were also increased in 71.42%, 83.33%, 57.14%, 71.43%, 100% and 42.86% in critically ill patients. Through our analysis, the age, comorbidities, lymphocyte count, eosinophil count, ferritin, CRP, LDH, PT and inflammatory cytokines were statistically significant along with the disease severity. Conclusion: We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage. Our research could assist the clinicians recognize severe and critically ill patients timely and focus on the expectant treatment for each patient. url: https://doi.org/10.7150/ijms.47935 doi: 10.7150/ijms.47935 id: cord-303816-c4z9ys3q author: Xu, YuShuang title: Diagnostic methods and drug therapies in patients with ischemic colitis date: 2020-09-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: Ischemic colitis (IC) is the most prevalent ischemic injury of thegastrointestinal tract. Clinical features of IC such as acute abdominal pain, hematochezia,and diarrhea are similar to those of acute mesenteric ischemia, inflammatorybowel disease, or infectious bowel disease, and their relative ambiguity candelay diagnosis and treatment. To comprehensively detail the current state ofdiagnostic methods and available drug therapies for detecting and treating IC,this review aims to provide a concise and practical summary of thecorresponding literature. METHODS: PubMed and Cochrane Library were searched toretrieve all published studies reporting the diagnostic methods and drugtherapies in patients with ischemic colitis. The search strategy of drugtherapy includes human and animal data. RESULTS: Colonoscopy combined with histopathologicalbiopsy is the standard of diagnosis for the IC. Most patients respond well tothe conservative treatment, and surgical consultation is needed when conservativetreatment is ineffective. Studies of potential drug therapy have beendeveloped, including phosphodiesterase type 5 inhibitors, pentoxifylline,rebamipide, prostaglandin E1, and polydeoxyribonucleotide. CONCLUSION: Accurate diagnoses and effective treatmentshave helped reduce the mortality rate and improve prognoses for patientsafflicted with IC, and corresponding drug therapies have been constantlyupdated as new research has emerged. url: https://www.ncbi.nlm.nih.gov/pubmed/32936393/ doi: 10.1007/s00384-020-03739-z id: cord-265082-gjbabh4g author: Xuan, Tian-ming title: Primary percutaneous coronary intervention in a COVID-19 patient with ST-segment elevation myocardial infarction after lung transplantation: a case report date: 2020-05-09 words: 1980.0 sentences: 98.0 pages: flesch: 45.0 cache: ./cache/cord-265082-gjbabh4g.txt txt: ./txt/cord-265082-gjbabh4g.txt summary: title: Primary percutaneous coronary intervention in a COVID-19 patient with ST-segment elevation myocardial infarction after lung transplantation: a case report We present an unusual case of a patient with bilateral-lung transplantation due to severe coronavirus disease 2019 , who subsequently suffered complications with acute myocardial infarction and underwent primary percutaneous coronary intervention (PCI). Based on the clinical characteristics of this case, we propose that the possible mechanism of myocardial infarction here included severe pulmonary infection, imbalance between coagulation and fibrinolysis subsequent to lung transplantation, changes in blood flow shear stress, and possible cytokine storms, which in combination led to plaque rupture in the LAD artery. In terms of treating acute myocardial infarction, considering that the patient had recent 2019-nCoV infection and bilateral-lung transplantation, we organized multiple rounds of multi-disciplinary discussions and decided that primary coronary intervention rather than thrombolytic therapy was suitable for the patient. In addition to the patient''s underlying severe coronary atherosclerosis, factors such as viral infection, inflammatory cytokine storm, hypoxia, blood loss, and bilateral-lung transplantation may contribute to the pathophysiology of myocardial infarction. abstract: 本文首次报告了重症新型冠状病毒肺炎(COVID-19)感染接受肺移植并行急症冠脉介入治疗的病 例。通过对多学科协作成功救治的总结, 为重症 COVID-19 救治提供经验。我们发现, 重症 COVID-19 感染在肺移植术后可能出现多种危险 因素诱发心肌梗死, 急症冠脉介入治疗是救治此 类患者的重要手段。 url: https://doi.org/10.1631/jzus.b2000182 doi: 10.1631/jzus.b2000182 id: cord-301342-ikvpkhfp author: Xue, Katherine S title: Parallel evolution of influenza across multiple spatiotemporal scales date: 2017-06-27 words: 6104.0 sentences: 301.0 pages: flesch: 50.0 cache: ./cache/cord-301342-ikvpkhfp.txt txt: ./txt/cord-301342-ikvpkhfp.txt summary: Viral variants that arise in the global influenza population begin as de novo mutations in single infected hosts, but the evolutionary dynamics that transform within-host variation to global genetic diversity are poorly understood. Recent deep-sequencing studies of human clinical samples suggest that influenza accumulates relatively limited genetic diversity within hosts during most acute infections (Dinis et al., 2016; Poon et al., 2016; Sobel Leonard et al., 2016; Debbink et al., 2017) , in line with earlier studies in dogs and horses Hoelzer et al., 2010) . We sequenced the full viral genome to high coverage directly from patient nasal wash samples by using influenza-specific reverse transcription and PCR (Hoffmann et al., 2001) to enrich for viral genetic material (Figure 2-figure supplement 1). Strikingly, many of the HA mutations that arise in parallel in multiple patients in our study also reach a high global frequency, which may reflect concordant antigenic selection at the within-host and global scales. abstract: Viral variants that arise in the global influenza population begin as de novo mutations in single infected hosts, but the evolutionary dynamics that transform within-host variation to global genetic diversity are poorly understood. Here, we demonstrate that influenza evolution within infected humans recapitulates many evolutionary dynamics observed at the global scale. We deep-sequence longitudinal samples from four immunocompromised patients with long-term H3N2 influenza infections. We find parallel evolution across three scales: within individual patients, in different patients in our study, and in the global influenza population. In hemagglutinin, a small set of mutations arises independently in multiple patients. These same mutations emerge repeatedly within single patients and compete with one another, providing a vivid clinical example of clonal interference. Many of these recurrent within-host mutations also reach a high global frequency in the decade following the patient infections. Our results demonstrate surprising concordance in evolutionary dynamics across multiple spatiotemporal scales. DOI: http://dx.doi.org/10.7554/eLife.26875.001 url: https://www.ncbi.nlm.nih.gov/pubmed/28653624/ doi: 10.7554/elife.26875 id: cord-295323-snrt9odv author: Yadav, Sandeep Kumar title: Creating Backup Management Resources for Spine Care during the Coronavirus Disease 2019 Pandemic date: 2020-05-14 words: 1137.0 sentences: 60.0 pages: flesch: 46.0 cache: ./cache/cord-295323-snrt9odv.txt txt: ./txt/cord-295323-snrt9odv.txt summary: Although the prevention and treatment of COVID 19 has become the priority for the majority of the population, most medical professionals are facing the challenge of balancing the management of this pandemic and treating patients with other diseases. Although the prevention and treatment of COVID 19 has become the priority for the majority of population, most medical professionals are facing the dilemma of balancing out essential healthcare for patients suffering from other diseases. Medical care personnel from all specialties are facing this situation and have established guidelines and recommendations that have contributed to the literature and are providing guidance for managing the pandemic. Thus, minimizing unnecessary patient visits, issuing preventive instructions to predisposed patients, ensuring the safety of the operative team, are maximizing the use of digital media for postoperative care surveillance are vital in the ongoing scenario. abstract: During this unprecedented time of the coronavirus disease 2019 (COVID 19) pandemic, most countries are struggling to optimize their healthcare resources. Although the prevention and treatment of COVID 19 has become the priority for the majority of the population, most medical professionals are facing the challenge of balancing the management of this pandemic and treating patients with other diseases. Healthcare professionals from all specialties are facing this situation and designing guidelines and recommendations that are contributing to the literature that is crucial for disease management at the current time. We share our experience with two ends of the spectra that we currently observe in spine patients. One group of patients included the non-operative cases that presented with back pain. Further, we discuss our experience with operative precautions and digitally assisted discharge. url: https://doi.org/10.31616/asj.2020.0193 doi: 10.31616/asj.2020.0193 id: cord-282956-f7if9e5q author: Yaghi, Shadi title: SARS2-CoV-2 and Stroke in a New York Healthcare System date: 2020-05-26 words: 2888.0 sentences: 151.0 pages: flesch: 40.0 cache: ./cache/cord-282956-f7if9e5q.txt txt: ./txt/cord-282956-f7if9e5q.txt summary: BACKGROUND AND PURPOSE: With the spread of coronavirus disease 2019 (COVID-19) during the current worldwide pandemic, there is mounting evidence that patients affected by the illness may develop clinically significant coagulopathy with thromboembolic complications including ischemic stroke. METHODS: We conducted a retrospective cohort study of consecutive patients with ischemic stroke who were hospitalized between March 15, 2020, and April 19, 2020, within a major health system in New York, the current global epicenter of the pandemic. In this multi-ethnic study, we report key demographic and clinical characteristics of patients who develop ischemic stroke associated with acute severe acute respiratory syndrome CoV-2 coronavirus infection. The observed rate of imaging-confirmed acute ischemic stroke in hospitalized patients with COVID-19 of 0.9% was lower compared with prior reports from Chinese COVID-19 studies. abstract: BACKGROUND AND PURPOSE: With the spread of coronavirus disease 2019 (COVID-19) during the current worldwide pandemic, there is mounting evidence that patients affected by the illness may develop clinically significant coagulopathy with thromboembolic complications including ischemic stroke. However, there is limited data on the clinical characteristics, stroke mechanism, and outcomes of patients who have a stroke and COVID-19. METHODS: We conducted a retrospective cohort study of consecutive patients with ischemic stroke who were hospitalized between March 15, 2020, and April 19, 2020, within a major health system in New York, the current global epicenter of the pandemic. We compared the clinical characteristics of stroke patients with a concurrent diagnosis of COVID-19 to stroke patients without COVID-19 (contemporary controls). In addition, we compared patients to a historical cohort of patients with ischemic stroke discharged from our hospital system between March 15, 2019, and April 15, 2019 (historical controls). RESULTS: During the study period in 2020, out of 3556 hospitalized patients with diagnosis of COVID-19 infection, 32 patients (0.9%) had imaging proven ischemic stroke. Cryptogenic stroke was more common in patients with COVID-19 (65.6%) as compared to contemporary controls (30.4%, P=0.003) and historical controls (25.0%, P<0.001). When compared with contemporary controls, COVID-19 positive patients had higher admission National Institutes of Health Stroke Scale score and higher peak D-dimer levels. When compared with historical controls, COVID-19 positive patients were more likely to be younger men with elevated troponin, higher admission National Institutes of Health Stroke Scale score, and higher erythrocyte sedimentation rate. Patients with COVID-19 and stroke had significantly higher mortality than historical and contemporary controls. CONCLUSIONS: We observed a low rate of imaging-confirmed ischemic stroke in hospitalized patients with COVID-19. Most strokes were cryptogenic, possibly related to an acquired hypercoagulability, and mortality was increased. Studies are needed to determine the utility of therapeutic anticoagulation for stroke and other thrombotic event prevention in patients with COVID-19. url: https://doi.org/10.1161/strokeaha.120.030335 doi: 10.1161/strokeaha.120.030335 id: cord-288575-srpc68t8 author: Yamakage, Michiaki title: Anesthesia in the times of COVID-19 date: 2020-05-25 words: 1314.0 sentences: 74.0 pages: flesch: 36.0 cache: ./cache/cord-288575-srpc68t8.txt txt: ./txt/cord-288575-srpc68t8.txt summary: As anesthesiologists, our work in operating rooms, emergency departments, and/or intensive care units often brings us in close proximity to the patient''s airway, exposing us to their aerosolized respiratory secretions. Wen X and Li Y briefly, but adequately, described anesthesia procedures for emergency surgery in patients with suspected or confirmed COVID-19 in their letter [4] . [25] described the anesthetic management of cardiac surgical patients in their literature; we, could not, however, find any further information regarding this, especially in relation to cardiac anesthesia. Anesthesia procedure of emergency operation for patients with suspected or confirmed COVID-19 Anesthetic management of patients with COVID 19 infections during emergency procedures Anesthesia management and perioperative infection control in patients with the novel coronavirus Recommendations for anesthesia in patients suspected of COVID-19 coronavirus infection Chinese society of anesthesiology expert consensus on anesthetic management of cardiac surgical patients with suspected or confirmed Coronavirus disease 2019 abstract: nan url: https://doi.org/10.1007/s00540-020-02798-4 doi: 10.1007/s00540-020-02798-4 id: cord-294139-78c5h7la author: Yamakawa, Mai title: Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis date: 2020-08-29 words: 3096.0 sentences: 171.0 pages: flesch: 45.0 cache: ./cache/cord-294139-78c5h7la.txt txt: ./txt/cord-294139-78c5h7la.txt summary: The frequency of common comorbidities (hypertension, dyslipidemia, diabetes mellitus, acute coronary syndrome /coronary artery disease), atrial fibrillation, stroke/transient ischemic attack, and malignancy), etiology of stroke if specified in the articles, and treatment (tissue plasminogen activator (tPA), mechanical thrombectomy, and anticoagulation were calculated by summation of events divided by the number of total patients from all studies whose information is available for each value. The salient findings of the study can be summarized as the followings; (1) the frequency of stroke in hospitalized COVID-19 patients was 1.1%, with mean days from COVID-19 symptom onset to stroke at 8 days, most commonly cryptogenic; (2) even with early case series with younger patients without a pre-existing medical condition, the mean age was 66.6, with slight male preponderance (65.6%); (3) stroke risk factors such as hypertension, dyslipidemia, and prior strokes were common as comorbidities; altered mental status was as frequent as 51.4 % as presenting symptom of stroke; (4) elevation of d-dimer and CRP were reproduced after synthesis of results; (5) case fatality rate was as high as 44.2% in patients with COVID-19 and stroke. abstract: BACKGROUND: The coronavirus disease 2019 (COVID-19) potentially increases the risk of thromboembolism and stroke. Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. We aimed to depict the frequency and clinical characteristics of COVID-19 patients with stroke. METHODS: PubMed and EMBASE were searched on June 10, 2020, to investigate COVID-19 and stroke through retrospective cross-sectional studies, case series/reports according to PRISMA guidelines. Study-specific estimates were combined using one-group meta-analysis in a random-effects model. RESULTS: 10 retrospective cohort studies and 16 case series/reports were identified including 183 patients with COVID-19 and stroke. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% ([95% confidential interval (CI)]: [0.6-1.6], I(2)=62.9%). Mean age was 66.6 ([58.4-74.9], I(2)=95.1%), 65.6% was male (61/93 patients). Mean days from symptom onset of COVID-19 to stroke was 8.0 ([4.1-11.9], p< 0.001, I(2)=93.1%). D-dimer was 3.3 μg/mL ([1.7-4.9], I(2)=86.3%), and cryptogenic stroke was most common as etiology at 50.7% ([31.0-70.4] I(2)=64.1%, 39/71patients). Case fatality rate was 44.2% ([27.9-60.5], I(2)=66.7%, 40/100 patients). CONCLUSIONS: This systematic review assessed the frequency and clinical characteristics of stroke in COVID-19 patients. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1 % and associated with older age and stroke risk factors. Frequent cryptogenic stroke and elevated d-dimer level support increased risk of thromboembolism in COVID-19 associated with high mortality. Further study is needed to elucidate the pathophysiology and prognosis of stroke in COVID-19 to achieve most effective care for this population. url: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105288 doi: 10.1016/j.jstrokecerebrovasdis.2020.105288 id: cord-258583-5qdthy0j author: Yan, He title: Multiple organ injury on admission predicts in‐hospital mortality in patients with COVID‐19 date: 2020-09-30 words: 2580.0 sentences: 154.0 pages: flesch: 48.0 cache: ./cache/cord-258583-5qdthy0j.txt txt: ./txt/cord-258583-5qdthy0j.txt summary: We aimed to explore the association between OI and mortality according to the number of affected organs (heart, liver, and kidney) in patients with COVID-19. The primary findings of this investigation were the following: Clinical studies suggested SARS-CoV-2 infection was associated with heart, kidney, and liver injury, which could serve as possible risk factors for increased disease severity. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Clinical characteristics of non-ICU hospitalized patients with coronavirus disease 2019 and liver injury: a retrospective study A comparative study of clinical presentation and risk factors for adverse outcome in patients hospitalised with acute respiratory disease due to MERS coronavirus or other causes Association of reninangiotensin system inhibitors with severity or risk of death in patients with hypertension hospitalized for coronavirus disease 2019 (COVID-19) infection in Wuhan, China Multiple organ injury on admission predicts in-hospital mortality in patients with COVID-19 abstract: Multiorgan injury has been implicated in patients with coronavirus disease 2019 (COVID‐19). We aim to assess the impact of organ injury (OI) on prognosis according to the number of affected organs at admission. This is a retrospective cohort study of patients with confirmed COVID‐19 in Wuhan Third Hospital & Tongren Hospital of Wuhan University from February 17 to March 22, 2020. We classified the patients according to the presence and number of damaged organs (heart, liver, and kidney). The percentage of patients with no, one, two, or three organs affected was 59.75%, 30.46%, 8.07%, and 1.72%, respectively. With the increasing number of OI, there is a tendency of gradual increase regarding the white blood cell counts, neutrophil counts, levels of C‐reactive protein (CRP), lactate dehydrogenase, D‐dimer, and fibrinogen as well as the incidence of most complications. In a Cox regression model, individuals with OI, old age, and an abnormal level of CRP were at a higher risk of death compared with those without. Patients with three organ injuries had the highest mortality rate (57.9%; hazard ratio [HR] with 95% confidence interval [CI] vs. patients without OI: 22.31 [10.42–47.77], those with two [23.6%; HR = 8.68, 95% CI = 4.58–16.48], one [8.6%; HR = 3.1, 95% CI = 1.7–5.7], or no OI [2.6%]; p < .001). The increasing number of OI was associated with a high risk of mortality in COVID‐19 infection. url: https://www.ncbi.nlm.nih.gov/pubmed/32949175/ doi: 10.1002/jmv.26534 id: cord-306377-s9j21zsy author: Yan, Li title: A machine learning-based model for survival prediction in patients with severe COVID-19 infection date: 2020-03-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The sudden increase of COVID-19 cases is putting a high pressure on healthcare services worldwide. At the current stage, fast, accurate and early clinical assessment of the disease severity is vital. To support decision making and logistical planning in healthcare systems, this study leverages a database of blood samples from 404 infected patients in the region of Wuhan, China to identify crucial predictive biomarkers of disease severity. For this purpose, machine learning tools selected three biomarkers that predict the survival of individual patients with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). In particular, relatively high levels of LDH alone seem to play a crucial role in distinguishing the vast majority of cases that require immediate medical attention. This finding is consistent with current medical knowledge that high LDH levels are associated with tissue breakdown occurring in various diseases, including pulmonary disorders such as pneumonia. Overall, this paper suggests a simple and operable formula to quickly predict patients at the highest risk, allowing them to be prioritised and potentially reducing the mortality rate. url: https://doi.org/10.1101/2020.02.27.20028027 doi: 10.1101/2020.02.27.20028027 id: cord-339568-th2xmhb6 author: Yan, Meitian title: Analysis of the diagnostic value of serum specific antibody testing for coronavirus disease 2019 date: 2020-06-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The coronavirus disease 2019 (COVID‐19) pandemic has spread to various regions worldwide. As of 27 April 2020, according to real‐time statistics released by the World Health Organization, there have been 84,341 confirmed cases and 4,643 deaths in China, with more than 2,979,484 confirmed cases and 206,450 deaths outside China. The detection of antibodies produced during the immune response to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has become an important laboratory method for the diagnosis of COVID‐19. However, at present, little research on these specific antibodies has been conducted. In this study, retrospective analysis was used to explore the dynamic changes of serum IgM and IgG antibody and factors affecting diagnostic efficacy, so as to provide a theoretical basis for clinical diagnosis and treatment. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/jmv.26230 doi: 10.1002/jmv.26230 id: cord-270019-er70ehk4 author: Yang, Kunyu title: Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study date: 2020-05-29 words: 4268.0 sentences: 242.0 pages: flesch: 48.0 cache: ./cache/cord-270019-er70ehk4.txt txt: ./txt/cord-270019-er70ehk4.txt summary: title: Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study METHODS: We did a retrospective, multicentre, cohort study of 205 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and with a pathological diagnosis of a malignant tumour in nine hospitals within Hubei, China, from Jan 13 to March 18, 2020. Multivariable regression analysis showed that receiving chemotherapy within 4 weeks before symptom onset (odds ratio [OR] 3·51 [95% CI 1·16–10·59]; p=0·026) and male sex (OR 3·86 [95% CI 1·57–9·50]; p=0·0033) were risk factors for death during admission to hospital. 5 In particular, male sex and receiving chemotherapy within 4 weeks before symptom onset were identified as risk factors for death in patients with cancer who were diagnosed with COVID-19. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China abstract: BACKGROUND: Patients with cancer are a high-risk population in the COVID-19 pandemic. We aimed to describe clinical characteristics and outcomes of patients with cancer and COVID-19, and examined risk factors for mortality in this population. METHODS: We did a retrospective, multicentre, cohort study of 205 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and with a pathological diagnosis of a malignant tumour in nine hospitals within Hubei, China, from Jan 13 to March 18, 2020. All patients were either discharged from hospitals or had died by April 20, 2020. Clinical characteristics, laboratory data, and cancer histories were compared between survivors and non-survivors by use of χ(2) test. Risk factors for mortality were identified by univariable and multivariable logistic regression models. FINDINGS: Between Jan 13 and Mar 18, 2020, 205 patients with cancer and laboratory-confirmed SARS-CoV-2 infection were enrolled (median age 63 years [IQR 56–70; range 14–96]; 109 [53%] women). 183 (89%) had solid tumours and 22 (11%) had haematological malignancies. The median duration of follow-up was 68 days (IQR 59–78). The most common solid tumour types were breast (40 [20%] patients), colorectal (28 [14%]), and lung cancer (24 [12%]). 54 (30%) of 182 patients received antitumour therapies within 4 weeks before symptom onset. 30 (15%) of 205 patients were transferred to an intensive care unit and 40 (20%) died during hospital admission. Patients with haematological malignancies had poorer prognoses than did those with solid tumours: nine (41%) of 22 patients with haematological malignancies died versus 31 (17%) of 183 patients with solid tumours (hazard ratio for death 3·28 [95% CI 1·56–6·91]; log rank p=0·0009). Multivariable regression analysis showed that receiving chemotherapy within 4 weeks before symptom onset (odds ratio [OR] 3·51 [95% CI 1·16–10·59]; p=0·026) and male sex (OR 3·86 [95% CI 1·57–9·50]; p=0·0033) were risk factors for death during admission to hospital. INTERPRETATION: Patients with cancer and COVID-19 who were admitted to hospital had a high case-fatality rate. Unfavourable prognostic factors, including receiving chemotherapy within 4 weeks before symptom onset and male sex, might help clinicians to identify patients at high risk of fatal outcomes. FUNDING: National Natural Science Foundation of China. url: https://www.ncbi.nlm.nih.gov/pubmed/32479787/ doi: 10.1016/s1470-2045(20)30310-7 id: cord-256893-3sh87h2x author: Yang, Li title: COVID-19: immunopathogenesis and Immunotherapeutics date: 2020-07-25 words: 5347.0 sentences: 300.0 pages: flesch: 42.0 cache: ./cache/cord-256893-3sh87h2x.txt txt: ./txt/cord-256893-3sh87h2x.txt summary: The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. The number of people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is rapidly increasing worldwide. The effect of elevated cytokine production on clinical manifestations Increasing evidence shows that viral infection can induce severe syndromes of shock and organ failure; 8,57 this phenomenon was also investigated for COVID-19. Treg cell-based therapy The dysregulated inflammatory processes caused by SARS-CoV-2 in patients with severe COVID-19 are partially due to the dysfunction of Tregs, which are responsible for inhibiting inflammation. abstract: The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms, septic shock, and severe multiple organ dysfunction. Therefore, mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease. Moreover, rational management of the immune responses to SARS-CoV-2, which includes enhancing anti-viral immunity while inhibiting systemic inflammation, may be key to successful treatment. In this review, we discuss the immunopathology of COVID-19, its potential mechanisms, and clinical implications to aid the development of new therapeutic strategies against COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32712629/ doi: 10.1038/s41392-020-00243-2 id: cord-310166-gt6icwul author: Yang, Xiang-Hong title: Expert recommendations on blood purification treatment protocol for patients with severe COVID-19(): Recommendation and consensus date: 2020-04-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease (COVID-19) was first diagnosed in Wuhan in December 2019. The World Health Organization defined the subsequent outbreak of COVID-19 worldwide as a public health emergency of international concern. Epidemiological data indicate that at least 20% of COVID-19 patients have severe disease. In addition to impairment of the respiratory system, acute kidney injury (AKI) is a major complication. Immune damage mediated by cytokine storms and concomitant AKI is a key factor for poor prognosis. Based on previous experience of blood purification for patients with severe acute respiratory syndrome and Middle East respiratory syndrome combined with clinical front-line practice, we developed a blood purification protocol for patients with severe COVID-19. This protocol is divided into four major steps. The first step is to assess whether patients with severe COVID-19 require blood purification. The second step is to prescribe a blood purification treatment for patients with COVID-19. The third step is to monitor and adjust parameters of blood purification. The fourth step is to evaluate the timing of discontinuation of blood purification. It is expected that blood purification will play a key role in effectively reducing the mortality of patients with severe COVID-19 through the standardized implementation of the present protocol. url: https://api.elsevier.com/content/article/pii/S2095882X20300372 doi: 10.1016/j.cdtm.2020.04.002 id: cord-327690-di7hfghi author: Yang, Xiaobo title: Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study date: 2020-02-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus 2 (SARS-CoV-2) started in December, 2019, in Wuhan, China. Information about critically ill patients with SARS-CoV-2 infection is scarce. We aimed to describe the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia. METHODS: In this single-centered, retrospective, observational study, we enrolled 52 critically ill adult patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital (Wuhan, China) between late December, 2019, and Jan 26, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. Data were compared between survivors and non-survivors. The primary outcome was 28-day mortality, as of Feb 9, 2020. Secondary outcomes included incidence of SARS-CoV-2-related acute respiratory distress syndrome (ARDS) and the proportion of patients requiring mechanical ventilation. FINDINGS: Of 710 patients with SARS-CoV-2 pneumonia, 52 critically ill adult patients were included. The mean age of the 52 patients was 59·7 (SD 13·3) years, 35 (67%) were men, 21 (40%) had chronic illness, 51 (98%) had fever. 32 (61·5%) patients had died at 28 days, and the median duration from admission to the intensive care unit (ICU) to death was 7 (IQR 3–11) days for non-survivors. Compared with survivors, non-survivors were older (64·6 years [11·2] vs 51·9 years [12·9]), more likely to develop ARDS (26 [81%] patients vs 9 [45%] patients), and more likely to receive mechanical ventilation (30 [94%] patients vs 7 [35%] patients), either invasively or non-invasively. Most patients had organ function damage, including 35 (67%) with ARDS, 15 (29%) with acute kidney injury, 12 (23%) with cardiac injury, 15 (29%) with liver dysfunction, and one (2%) with pneumothorax. 37 (71%) patients required mechanical ventilation. Hospital-acquired infection occurred in seven (13·5%) patients. INTERPRETATION: The mortality of critically ill patients with SARS-CoV-2 pneumonia is considerable. The survival time of the non-survivors is likely to be within 1–2 weeks after ICU admission. Older patients (>65 years) with comorbidities and ARDS are at increased risk of death. The severity of SARS-CoV-2 pneumonia poses great strain on critical care resources in hospitals, especially if they are not adequately staffed or resourced. FUNDING: None. url: https://www.sciencedirect.com/science/article/pii/S2213260020300795 doi: 10.1016/s2213-2600(20)30079-5 id: cord-318355-38x3f3ee author: Yang, Yang title: Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with Sars‐COV‐2 date: 2020-07-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTS: To assess the association between adipose tissue distribution and severity of clinical course in patients with severe acute respiratory syndrome coronavirus 2 (SARS­CoV­2). METHODS: For this retrospective study, 143 hospitalized patients with confirmed coronavirus disease 2019(COVID‐19) who underwent un‐enhanced abdominal computed tomography (CT) scan between January 1(th), 2020 and March 30(th), 2020 were included. Univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with the severity of COVID‐19 infection. RESULTS: There were 45 patients who were identified as critically ill. High visceral to subcutaneous adipose tissue area ratio (VSR, called visceral adiposity) (OR: 2.47, 95CI: 1.05 to 5.98, p=0.040) and low mean attenuation of skeletal muscle (SMD, called high intramuscular fat [IMF] deposition) (OR: 11.90, 95CI: 4.50 to 36.14, p<0.001) were independent risk factors for critical illness. Furthermore, visceral adiposity or high IMF deposition increased the risk of mechanical ventilation (p=0.013, p<0.001; respectively). High IMF deposition increased the risk of death (p=0.012). CONCLUSION: COVID‐19 patients with visceral adiposity or high IMF deposition have higher risk for critical illness. Hence, patients with abdominal obesity should be monitored more carefully when hospitalized. url: https://doi.org/10.1002/oby.22971 doi: 10.1002/oby.22971 id: cord-355191-jghvq3cy author: Yang, Yang title: A Rare Case of Immune Thrombocytopenic Purpura Secondary to COVID‐19 date: 2020-05-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus Disease 2019 (COVID‐19) is a newly emerging infectious disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). After its first occurrence in Wuhan of China from December 2019, COVID‐19 rapidly spread around the world. Studies have shown that coagulation dysfunction is one of the important reason causing death of COVID‐19 patients and appeared in many patients. However, cases of COVID‐19 with immune thrombocytopenic purpura were very rare. Here, a patient with immune thrombocytopenic purpura in Huoshenshan Hospital (Wuhan, China) was reported, whose laboratory data, clinical treatment and hospital outcome was described in this study. Fortunately, immune thrombocytopenic purpura with COVID‐19 of the patient was diagnosed and treated in time and cured eventually. This case illustrates the need to be vigilant for complications associated with COVID‐19. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32441787/ doi: 10.1002/jmv.26051 id: cord-264972-hrbo3awj author: Yee, Colin title: Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting date: 2016-11-01 words: 1701.0 sentences: 93.0 pages: flesch: 36.0 cache: ./cache/cord-264972-hrbo3awj.txt txt: ./txt/cord-264972-hrbo3awj.txt summary: title: Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting A retrospective cohort design was used to study the impact of a multiplex respiratory virus panel polymerase chain reaction test in 186 adult patients with suspected influenza-like illness. The objective of our study was to evaluate the impact of the MRVP test on the use of antiviral and antimicrobial therapy among adult patients in a hospital setting (either emergency room or inpatients) with suspected influenza-like illness. We evaluated whether the MRVP test result was associated with the changes in management in antiviral and antibiotic treatment (see the definition in Supplementary Appendix S1), after stratifying by patient location. We conclude that the MRVP test could potentially positively impact the clinical management of respiratory viral infections in adult patients. abstract: A retrospective cohort design was used to study the impact of a multiplex respiratory virus panel polymerase chain reaction test in 186 adult patients with suspected influenza-like illness. Decisions regarding continuation of empirical antiviral therapy appear to be impacted by the test. However, the impact on reducing antibiotic use remains unclear. url: https://doi.org/10.1016/j.ajic.2016.04.221 doi: 10.1016/j.ajic.2016.04.221 id: cord-349533-51cex2sl author: Yeoh, Su-Ann title: Are treat-to-target and dose tapering strategies for rheumatoid arthritis possible during the COVID-19 pandemic? date: 2020-06-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S2665991320301752 doi: 10.1016/s2665-9913(20)30175-2 id: cord-325970-ivtunxrd author: Yerramilli, Divya title: Palliative Radiotherapy for Oncologic Emergencies in the setting of COVID-19: Approaches to Balancing Risks and Benefits date: 2020-04-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2452109420300695 doi: 10.1016/j.adro.2020.04.001 id: cord-305422-t8azymo7 author: Yi, Ye title: COVID-19: what has been learned and to be learned about the novel coronavirus disease date: 2020-03-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The outbreak of Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), has thus far killed over 3,000 people and infected over 80,000 in China and elsewhere in the world, resulting in catastrophe for humans. Similar to its homologous virus, SARS-CoV, which caused SARS in thousands of people in 2003, SARS-CoV-2 might also be transmitted from the bats and causes similar symptoms through a similar mechanism. However, COVID-19 has lower severity and mortality than SARS but is much more transmissive and affects more elderly individuals than youth and more men than women. In response to the rapidly increasing number of publications on the emerging disease, this article attempts to provide a timely and comprehensive review of the swiftly developing research subject. We will cover the basics about the epidemiology, etiology, virology, diagnosis, treatment, prognosis, and prevention of the disease. Although many questions still require answers, we hope that this review helps in the understanding and eradication of the threatening disease. url: https://www.ncbi.nlm.nih.gov/pubmed/32226295/ doi: 10.7150/ijbs.45134 id: cord-339266-glmshsh6 author: Yin, R. title: Clinical characteristics of 106 patients with neurological diseases and co-morbid coronavirus disease 2019: a retrospective study date: 2020-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objectives:To describe the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with co-morbid neurological symptoms. Design:Retrospective case series. Setting:Huoshenshan Hospital in Wuhan, China. Participants:From 4 February to 14 April 2020, 106 patients with neurological diseases were enrolled from all patients in the hospital with confirmed COVID-19 and divided into a severe group and a nonsevere group according to their COVID-19 diagnosis. Main outcome measures:Clinical characteristics, laboratory results, imaging findings, and treatment methods were all retrieved through an electronic medical records system and recorded in spreadsheets. Results:The mean (standard deviation, SD) age of patients was 72.7 (11.8) years, and 64 patients were male (60.4%). Among patients with co-morbid neurological diseases, 81 had a previous cerebral infarction (76.4%), 20 had dementia (18.9%), 10 had acute cerebral infarction (9.4%), 5 had sequelae of cerebral haemorrhage (4.7%), 4 had intracranial mass lesions (3.8%), 3 had epilepsy (2.8%), 2 had Parkinsons disease (1.9%), and 1 had myelopathy (0.9%). Fever (n = 62, 58.5%) was the most common symptom. The most common neurological symptoms were myalgia (n = 26, 24.5%), followed by extremity paralysis (n = 20, 18.9%), impaired consciousness (n = 17, 16%), and positive focal neurological signs (n = 42, 39.6%). Eight patients (7.5%) died. There were more patients with altered mental status in the severe group than in the non-severe group (6 [10.2%] vs. 0, P = 0.033). The inflammatory response in the severe group was more significant than that in the non-severe group. There were more patients taking anticoagulant drugs (25 [42.4%] vs. 4 [8.5%], P < 0.001) and sedative drugs (22 [37.3%] vs. 9 [19.1%], P = 0.041) in the severe group than in the non-severe group. Amid all 93 patients with cerebrovascular diseases, only 32 (34.4%) were taking aspirin, 13 (14%) taking clopidogrel, and 33 (35.5%) taking statins. Conclusions:Patients with COVID-19 with co-morbid neurological diseases had an advanced age, a high rate of severe illness, and a high mortality rate. Among the neurological symptoms, altered mental status was more common in patients with severe COVID-19 with co-morbid neurological diseases. url: https://doi.org/10.1101/2020.04.29.20085415 doi: 10.1101/2020.04.29.20085415 id: cord-011103-sstpidvk author: Younan, Duraid title: Factors Predictive of Ventilator-associated Pneumonia in Critically Ill Trauma Patients date: 2019-11-26 words: 2391.0 sentences: 111.0 pages: flesch: 46.0 cache: ./cache/cord-011103-sstpidvk.txt txt: ./txt/cord-011103-sstpidvk.txt summary: CONCLUSIONS: Among critically ill trauma patients, acute kidney injury, injury to the spine, face or sternum, massive transfusion and intensive care unit length of stay were associated with VAP. Variables collected from the patients'' medical records and trauma database included age, race, gender (demographics), presenting vital signs, injury type and severity, the presence of ventilator-associated pneumonia, hospital and intensive care unit length of stay and survival data. We found that, among critically ill trauma patients admitted to the intensive care unit, injury to the spine, face or sternum, massive transfusion, acute kidney injury and intensive care unit length of stay were associated with ventilator-associated pneumonia (VAP). Among critically ill trauma patients admitted to the intensive care unit, acute kidney injury, injury to the spine, face or sternum, massive transfusion and intensive care unit length of stay were associated with VAP. abstract: BACKGROUND: Ventilator-associated pneumonia (VAP) is a serious complication of mechanical ventilation. We sought to investigate factors associated with the development of VAP in critically ill trauma patients. METHODS: We conducted a retrospective review of trauma patients admitted to our trauma intensive care unit between 2016 and 2018. Patients with ventilator-associated pneumonia were identified from the trauma database. Data collected from the trauma database included demographics (age, gender and race), mechanism of injury (blunt, penetrating), injury severity (injury severity score “ISS”), the presence of VAP, transfused blood products and presenting vital signs. RESULTS: A total of 1403 patients were admitted to the trauma intensive care unit (TICU) during the study period; of these, 45 had ventilator-associated pneumonia. Patients with VAP were older (p = 0.030), and they had a higher incidence of massive transfusion (p = 0.015) and received more packed cells in the first 24 h of admission (p = 0.028). They had a higher incidence of face injury (p = 0.001), injury to sternum (p = 0.011) and injury to spine (p = 0.024). Patients with VAP also had a higher incidence of acute kidney injury (AKI) (p < 0.001) and had a longer ICU (p < 0.001) and hospital length of stay (p < 0.001). Multiple logistic regression models controlling for age and injury severity (ISS) showed massive transfusion (p = 0.017), AKI (p < 0.001), injury to face (p < 0.001), injury to sternum (p = 0.007), injury to spine (p = 0.047) and ICU length of stay (p < 0.001) to be independent predictors of VAP. CONCLUSIONS: Among critically ill trauma patients, acute kidney injury, injury to the spine, face or sternum, massive transfusion and intensive care unit length of stay were associated with VAP. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223571/ doi: 10.1007/s00268-019-05286-3 id: cord-034036-1wigu3i3 author: Yu, Changhao title: Current epidemiological and etiological characteristics and treatment of seizures or epilepsy in patients with HIV infection date: 2020-10-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Seizures or epilepsy is one of the common serious complications in patients with advanced human immunodeficiency virus (HIV) infection or diagnosed with immune deficiency syndrome, with higher incidence and prevalence than in the general population. Generalized seizures are the most common type in the patients. Opportunistic infections are a stereotypical predisposing factor for seizures in HIV patients, but a variety of pathogenic factors can also be found in these patients, such as metabolic perturbation and drug-drug interactions. The diagnostic criteria for seizures in these patients are the same as those in the general population. As HIV patients with seizures need to take both antivirals and antiepileptic drugs, the risk of drug-drug interactions is greatly increased, and the side effects of drugs may also become more prominent. At present, most experience in antiepileptic drug usage has come from the general population, and there is still a lack of guidance of antiepileptic drug use in special groups such as the HIV-infected people. Unlike the old-generation drugs that involve metabolisms through CYP450, the first-line antiepileptic drugs usually bypass CYP450, thus having less drug-drug interactions. In this review, we summarize the recent research progress on the above-mentioned widely discussed topics and make a prospect on future research direction. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575336/ doi: 10.1186/s42494-020-00028-8 id: cord-309517-yh4d414y author: Yu, Chao title: Characteristics of asymptomatic COVID-19 infection and progression: A multicenter, retrospective study date: 2020-08-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Novel coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has spread globally since the end of 2019. Asymptomatic carriers are of great concern as they can undermine the interventions to stop the pandemic. However, there is limited information about the characteristics and outcomes of the asymptomatic patients. Therefore, we conducted this retrospective study and retrieved data of 79 asymptomatic COVID-19 patients at admission from three designated hospitals in Wuhan, China. The asymptomatic patients could happen at any age, ranged from 9 to 96 years. These patients also had lower levels of alanine aminotransferase and C-reactive protein. Patchy shadowing was the most common manifestation in computed tomography scan. Some asymptomatic carriers developed mild or moderate symptoms during hospitalization. Age and comorbidities, especially hypertension, may be predictive factors for symptom development in the initially asymptomatic carriers at admission. Early detection and treatment for these presymptomatic patients before symptom onset can shorten the communicable period for the coronavirus and reduce the occurrence of severe cases. url: https://doi.org/10.1080/21505594.2020.1802194 doi: 10.1080/21505594.2020.1802194 id: cord-283231-ju71zm7w author: Yu, Juan title: RE: Respiratory Infectious Disease in Resource Limited Setting: Radiology Management Advice date: 2020-04-15 words: 558.0 sentences: 40.0 pages: flesch: 56.0 cache: ./cache/cord-283231-ju71zm7w.txt txt: ./txt/cord-283231-ju71zm7w.txt summary: title: RE: Respiratory Infectious Disease in Resource Limited Setting: Radiology Management Advice Dear Dr. Joob, Dr. Wiwanitkit, and Editors-In many countries and regions where access to health care is limited, it is important for medical institutions to develop appropriate programmes to prevent and control respiratory infections. Special examination rooms and passageways should be reserved for suspected patients. If there is no special examination room for suspected patients, try to divide the time period for the ordinary patients and suspected patients. The use of mobile X-ray machines is also a good option in emergency departments, intensive care units, and isolation rooms. It is best to use a special examination room, if not, the method of inspection by time interval is adopted (1,2). (5) Layout of radiology department: The examination room and operation room that directly contact with patients are contaminated areas, and there should be a buffer zone between contaminated areas and cleaning areas. abstract: nan url: https://doi.org/10.1016/j.acra.2020.03.020 doi: 10.1016/j.acra.2020.03.020 id: cord-024956-oht0v33s author: Yu, Minhua title: Thin-section Chest CT Imaging of Coronavirus Disease 2019 Pneumonia: Comparison Between Patients with Mild and Severe Disease date: 2020-04-23 words: 2496.0 sentences: 157.0 pages: flesch: 50.0 cache: ./cache/cord-024956-oht0v33s.txt txt: ./txt/cord-024956-oht0v33s.txt summary: title: Thin-section Chest CT Imaging of Coronavirus Disease 2019 Pneumonia: Comparison Between Patients with Mild and Severe Disease The purpose was to compare radiological characteristics of COVID-19 pneumonia on thin-section CT upon admission between patients with mild and severe disease. Thus, the purpose of our current study was to compare radiological characteristics of COVID-19 pneumonia on thin-section CT between patients with mild and severe disease. We studied the findings on chest CT at hospital presentation in patients diagnosed with COVID-19 pneumonia, focusing our comparisons between the patients with mild and severe disease. As for characteristics in CT images, COVID-19 pneumonia seems to be more extensive in the severe form of disease, involving a larger number of lung segments. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in wuhan, china abstract: PURPOSE: Although CT imaging features of Coronavirus Disease 2019 (COVID-19) pneumonia have already been published in the literature, there was little attention to distinctive imaging features encountered between patients with mild and severe forms of the disease. The purpose was to compare radiological characteristics of COVID-19 pneumonia on thin-section CT upon admission between patients with mild and severe disease. MATERIALS AND METHODS: Seventy COVID-19 pneumonia patients admitted to Zhongnan Hospital of Wuhan University between January 20 and January 27, 2020 were enrolled. Based on the World Health Organization guidelines, 50 patients were categorized with mild form and 20 with severe form based on clinical conditions. Imaging features, clinical, and laboratory data were reviewed and compared. RESULTS: Patients with severe form (median age, 65.00; IQR: 54.75-75.00) were older than those with mild form of disease (median age, 42.5; IQR: 32.75-58.50) (P<0.001). Patients with severe form of disease had more lung segments involved (median number of segments: 7.5 vs. 17.5, P=<0.001) and also larger opacities (median number of segments with opacities measuring 3 cm to less than 50% of the lung segment: 5.5 vs. 2.0, P=0.006; ≥ 50% of lung segment: 7.5 vs. 0.0, P<0.001). They also had more interlobular septal thickening (75% vs. 28%, P<0.001), higher prevalence of air bronchograms (70% vs. 32%, P=0.004), and pleural effusions (40% vs 14%, P=0.017). CONCLUSION: Ground-glass opacities with or without consolidation in a peripheral and basilar predominant distribution were the most common findings in COVID-19 pneumonia. Patients with severe form of the disease had more extensive opacification of the lung parenchyma than did patients with mild disease. Interlobular septal thickening, air bronchograms, and pleural effusions were also more prevalent in severe COVID-19. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233444/ doi: 10.1148/ryct.2020200126 id: cord-354223-0ckpz0bx author: Yu, Pengming title: Early Rehabilitation for Critically Ill Patients With COVID-19: More Benefits Than Risks date: 2020-04-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32437114/ doi: 10.1097/phm.0000000000001445 id: cord-285414-vd2d7db2 author: Yu, Qian title: Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients date: 2020-04-27 words: 3080.0 sentences: 188.0 pages: flesch: 48.0 cache: ./cache/cord-285414-vd2d7db2.txt txt: ./txt/cord-285414-vd2d7db2.txt summary: title: Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients In this study, we aimed to assess the imaging characteristics and risk factors associated with adverse composite endpoints in patients with COVID-19 pneumonia. In this study, we aimed to report the quantitative imaging characteristics and risk factors for adverse composite endpoints, including admission to ICU, acute respiratory failure occurrence, and shock during hospitalization in patients with COVID-19 pneumonia in Jiangsu province, China. In this retrospective, cohort, and AI-assisted study, we reported the imaging risk factors associated with adverse clinical composite endpoints, including admission to ICU, acute respiratory failure, and shock during hospitalization in patients with COVID-19 pneumonia in Jiangsu province, China. Our study of 421 COVID-19 patients suggested an increased pulmonary lesion in bilateral upper lungs were independent risk factors for adverse clinical outcomes, which as far as we know, has not been reported. abstract: Rationale: Chest computed tomography (CT) has been used for the coronavirus disease 2019 (COVID-19) monitoring. However, the imaging risk factors for poor clinical outcomes remain unclear. In this study, we aimed to assess the imaging characteristics and risk factors associated with adverse composite endpoints in patients with COVID-19 pneumonia. Methods: This retrospective cohort study enrolled patients with laboratory-confirmed COVID-19 from 24 designated hospitals in Jiangsu province, China, between 10 January and 18 February 2020. Clinical and initial CT findings at admission were extracted from medical records. Patients aged < 18 years or without available clinical or CT records were excluded. The composite endpoints were admission to ICU, acute respiratory failure occurrence, or shock during hospitalization. The volume, density, and location of lesions, including ground-glass opacity (GGO) and consolidation, were quantitatively analyzed in each patient. Multivariable logistic regression models were used to identify the risk factors among age and CT parameters associated with the composite endpoints. Results: In this study, 625 laboratory-confirmed COVID-19 patients were enrolled; among them, 179 patients without an initial CT at admission and 25 patients aged < 18 years old were excluded and 421 patients were included in analysis. The median age was 48.0 years and the male proportion was 53% (224/421). During the follow-up period, 64 (15%) patients had a composite endpoint. There was an association of older age (odds ratio [OR], 1.04; 95% confidence interval [CI]: 1.01-1.06; P = 0.003), larger consolidation lesions in the upper lung (Right: OR, 1.13; 95%CI: 1.03-1.25, P =0.01; Left: OR,1.15; 95%CI: 1.01-1.32; P = 0.04) with increased odds of adverse endpoints. Conclusion: There was an association of older age and larger consolidation in upper lungs on admission with higher odds of poor outcomes in patients with COVID-19. url: https://doi.org/10.7150/thno.46465 doi: 10.7150/thno.46465 id: cord-029859-fhm0d9t9 author: Yue, Ling title: How psychiatrists coordinate treatment for COVID-19: a retrospective study and experience from China date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Patients with COVID-19 are at high risk of developing mental health problems; however, the prevalence and management of mental disorders and how psychiatrists coordinate the treatment are unclear. AIMS: We aimed to investigate the mental health problems of patients infected with COVID-19 and to identify the role of psychiatrists in the clinical treatment team during the pandemic. We also share the experience of psychiatric consultations of patients with COVID-19 in Shanghai, China. METHODS: We analysed data from the psychiatric medical records of 329 patients with COVID-19 in the Shanghai Public Health Clinical Center from 20 January to 8 March 2020. We collected information including sociodemographic characteristics, whether patients received psychiatric consultation, mental health symptoms, psychiatric diagnoses, psychiatric treatments and severity level of COVID-19. RESULTS: Psychiatric consultations were received by 84 (25.5%) patients with COVID-19. The most common symptoms of mental health problems were sleep disorders (75%), anxiety (58.3%) and depressive symptoms (11.9%). The psychiatric consultation rate was highest in critically ill patients (69.2%), with affective symptoms or disturbed behaviour as their main mental health problems. Psychiatric diagnoses for patients who received consultation included acute stress reaction (39.3%), sleep disorders (33.3%), anxiety (15.5%), depression (7.1%) and delirium (4.8%). In terms of psychiatric treatments, 86.9% of patients who received psychiatric consultation were treated with psychotropic medications, including non-benzodiazepine sedative-hypnotic agents (54.8%), antidepressants (26.2%), benzodiazepines (22.6%) and antipsychotics (10.7%). Among the 76 patients who were discharged from the hospital, 79% had recovered from mental health problems and were not prescribed any psychotropic medications. The symptoms of the remaining 21% of patients had improved and they were prescribed medications to continue the treatment. CONCLUSIONS: This is the first study to report psychiatric consultations for patients with COVID-19. Our study indicated that a considerable proportion of patients with COVID-19, especially critically ill cases, experienced mental health problems. Given the remarkable effect of psychiatric treatments, we recommend that psychiatrists be timely and actively involved in the treatment of COVID-19. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387309/ doi: 10.1136/gpsych-2020-100272 id: cord-009697-dq4y89ab author: Yuen, Eddie title: Role of absolute lymphocyte count in the screening of patients with suspected SARS date: 2003-07-25 words: 1510.0 sentences: 92.0 pages: flesch: 59.0 cache: ./cache/cord-009697-dq4y89ab.txt txt: ./txt/cord-009697-dq4y89ab.txt summary: 3 This multicentre, placebo-controlled, randomized, double-blind trial in 6213 patients with acute ST-elevation myocardial infarct (STEMI) found that magnesium sulphate, (2 g intravenous bolus over 15 min followed by a 17 g infusion over 24 h), administered within 6 hours of onset of symptoms did not have any effect on the primary end-point of 30 day all-cause mortality when compared with placebo (15.3% 30 day mortality in the magnesium group vs 15.2% in the placebo group; odds ratio 1.0; 95% CI 0.9-1.2; P = 0.96). As the investigators point out in the discussion of their paper, this means that 68 684 patients have been studied over the past 22 years in 14 randomized trials of magnesium in myocardial infarction. Second, a multicentre, placebo-controlled, randomized, double-blind trial of intravenous magnesium sulphate in 248 patients with acute severe asthma was recently reported. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163475/ doi: 10.1046/j.1442-2026.2003.00486_3.x id: cord-000229-9fr0m92p author: Yun, Tae Jin title: Radiological and Clinical Characteristics of a Military Outbreak of Pandemic H1N1 2009 Influenza Virus Infection date: 2010-06-21 words: 3214.0 sentences: 137.0 pages: flesch: 45.0 cache: ./cache/cord-000229-9fr0m92p.txt txt: ./txt/cord-000229-9fr0m92p.txt summary: However, six of 12 patients who underwent thin-section CT examinations showed abnormal findings for small ground-glass opacities (GGOs) in addition to poorly-defined nodules with upper lobe predominance. CONCLUSION: In a population of healthy young adults, elevated CRP with normal ESR and white blood cell levels combined with GGOs and nodules on thin-section CT scans may indicate early signs of infection by the pandemic H1N1 2009 influenza virus. In this article, we aim to describe detailed clinical characteristics and radiologic features of chest radiographs and thin-section CT findings of patients confirmed with the pandemic H1N1 2009 influenza virus infection occurring in a semi-closed setting. Most patients in our study did not show a severe hospital course, although one patient''s symptoms aggravated into ARDS and needed mechanical ventilation before laboratory tests revealed that he had the pandemic H1N1 2009 influenza virus infection. abstract: OBJECTIVE: To describe detailed clinical and radiological features of the pandemic H1N1 2009 influenza viral infection among healthy young males in a semi-closed institutionalized setting. MATERIALS AND METHODS: A total of 18 patients confirmed with the pandemic H1N1 2009 influenza virus infection from July 18 to July 30, 2009 were enrolled in this study. Each patient underwent an evaluation to determine detailed clinical and radiological features. RESULTS: All patients presented with high fever (> 38.0℃), with accompanying symptoms of cough, rhinorrhea, sore throat, myalgia and diarrhea, and increased C-reactive protein (CRP) values with no leukocytosis nor elevated erythrocyte sedimentation rate (ESR). All patients, including one patient who progressed into acute respiratory distress syndrome, were treated with oseltamivir phosphate and quickly recovered from their symptoms. Chest radiographs showed abnormalities of small nodules and lobar consolidation in only two out of 18 patients. However, six of 12 patients who underwent thin-section CT examinations showed abnormal findings for small ground-glass opacities (GGOs) in addition to poorly-defined nodules with upper lobe predominance. CONCLUSION: In a population of healthy young adults, elevated CRP with normal ESR and white blood cell levels combined with GGOs and nodules on thin-section CT scans may indicate early signs of infection by the pandemic H1N1 2009 influenza virus. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893312/ doi: 10.3348/kjr.2010.11.4.417 id: cord-276241-4g6pa7kz author: Yurttaş, Berna title: Characteristics and outcomes of Behçet’s syndrome patients with Coronavirus Disease 2019: a case series of 10 patients date: 2020-07-09 words: 1735.0 sentences: 109.0 pages: flesch: 54.0 cache: ./cache/cord-276241-4g6pa7kz.txt txt: ./txt/cord-276241-4g6pa7kz.txt summary: Recently two European centers reported that the prevalence of SARS-CoV-2 infection among patients with systemic autoimmune diseases was comparable to that observed in the general population [8, 9] . Table 2 shows presenting symptoms, laboratory tests, length of hospital stay and management related to COVID-19. Due to parenchymal CNS involvement with a progressive relapsing course, he received several immunosuppressive agents including cyclophosphamide and Case no 3, 4, 5 and 6 had been diagnosed with COVID-19 pneumonia. Our case series suggests that BS patients are much younger and appear to have increased risk for severe outcome when infected with COVID-19 compared to the general population. In line with our observations, very recently a study from Wuhan, China, reported that respiratory failure was more commonly observed in RD patients infected with COVID-19 compared to those without RD [15] . High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32647946/ doi: 10.1007/s11739-020-02427-8 id: cord-351528-23lbs8al author: Zacharia, Brad E title: Letter: Surgical Management of Brain Tumor Patients in the COVID-19 Era date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/neuros/nyaa162 doi: 10.1093/neuros/nyaa162 id: cord-339940-80757pwu author: Zaidi, S. Javed title: A novel approach to the diagnosis and treatment of hemoptysis in infants: A case series date: 2018-09-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Hemoptysis in children is an uncommon presenting symptom but can be life‐threatening if massive. Cardiac catheterization and coil embolization of aorto‐pulmonary collateral vessels (APCs) is uncommon in pediatric hemoptysis patients without congenital heart disease. METHODS: We present a series of seven infants (≤12 months of age) with hemoptysis, all of whom underwent cardiac catheterization to look for and intervene upon APCs, if found. Only those patients who underwent both bronchoscopy as well as cardiac catheterization from January 1995 to January 2015 were included in this retrospective review. RESULTS: Seven patients met inclusion criteria, and three had a history of recurrent hemoptysis. The mean age was 3 months. Four had evidence of bleeding on bronchoscopy. All seven had respiratory distress which necessitated ICU admission; five required mechanical ventilation. Cardiac catheterization showed significant APCs (>2 mm) in six of the seven studied patients, all of which were coil embolized. One patient had no significant APCs and therefore, no embolization. All patients had complete resolution with no recurrences during the 10‐20‐year outpatient follow‐up period. Chest CT scans were not helpful in delineating the site or etiology of bleeding in any patient. CONCLUSIONS: APCs should be considered as a differential diagnosis for pulmonary hemorrhage in infants after more common causes have been ruled out. url: https://doi.org/10.1002/ppul.24160 doi: 10.1002/ppul.24160 id: cord-327577-c0d09cyk author: Zamora, Alberto title: Heart failure, zip code, and telemetry: a trinomial in need of understanding date: 2020-08-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2529912320300619 doi: 10.1016/j.artere.2020.07.005 id: cord-252374-obl6pfpf author: Zaninotto, Martina title: Cardiac troponin I in SARS-CoV-2-patients: the additional prognostic value of serial monitoring date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background Major cardiac complications have been described in SARS-CoV-2 patients. The study of cardiac troponin’ kinetic release is the recommended approach to differentiate acute from chronic injury, in order to clinically manage different cardiac diseases. Aim To investigate whether serial measurements of high sensitivity troponin I (hs-cTnI) might provide additional information in SARS-CoV-2 patients’s clinical management. Methods 113 consecutive patients suffering from microbiology proven SARS-CoV2-infection have been studied. Hs-cTnI has been measured in lithium-heparin plasma samples using STAT High Sensitive Troponin I (Architect i2000, Abbott Diagnostics), being 99th percentiles 16 and 34 ng/L for females and males respectively. Results In 69 out of 113 patients hs-cTnI has been measured, showing in 31 (45%) values higher than 99th percentiles in at least one occasion. In 50 patients (72%) a kinetic evaluation (at least 2 measurements during 24 h) has been carried out. Patients were subdivided into five groups: 1 (n=44) and 2 (n=19) no measurement of hs-cTnI or no monitoring respectively; 3 (n=15) no significant variations during monitoring; 4 (n=8) and 5 (n=27) significant variations with values persistently below or sometimes higher than 99th percentiles, respectively. Group 5 patients had a longer hospital stay (median 37 days, p=0.0001), a more aggressive disease (6 out of 27, 22%, died), more often need admission to ICU (n=25, 92.6%, p<0.0001), and show one or more peak values, sometime preceded by severe hypoxia. Conclusions In SARS-CoV-2 patients, hs-cTnI serial monitoring may provide additional data to stratify risk, establish prognosis and gaining epidemiological insight on cardiac involvement in this pandemic disease. url: https://www.sciencedirect.com/science/article/pii/S000989812030468X?v=s5 doi: 10.1016/j.cca.2020.09.036 id: cord-322861-q7uk6rdp author: Zanon, Ezio title: How haemophilia A impacts severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) treatment: a case report date: 2020-07-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The typical symptoms of COVID-19 mimic those of the common season flu. In addition, several changes in the coagulation processes have been observed. To date, it’s not fully clear how COVID-19 may affect patients with hereditary bleeding disorders. Anticoagulation in patients with haemophilia is still debated, but in this case could be needed. We are reporting a case of an elderly patient with mild haemophilia A hospitalized for Sars-Cov-2. On the 15th day of hospitalization, we observed an increase of all coagulation parameters. An antithrombotic prophylaxis at low dosage was immediately started, then increased at prophylactic dosage. Even if much more data are needed to ascertain the real thrombotic risk of haemophilia A in COVID-19 patients, it’s clear that the FVIII and vWF should be strictly monitored in order to promptly establish an adequate treatment and avoid the onset of thromboembolic events, even fatal, causing many deaths in COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32676882/ doi: 10.1007/s11239-020-02227-z id: cord-280097-f7ky61ds author: Zarogoulidis, Paul title: Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? date: 2011-01-07 words: 3167.0 sentences: 194.0 pages: flesch: 55.0 cache: ./cache/cord-280097-f7ky61ds.txt txt: ./txt/cord-280097-f7ky61ds.txt summary: title: Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? BACKGROUND: The World Health Organization alert for the H1N1 influenza pandemic led to the implementation of certain measures regarding admission of patients with flu-like symptoms. The aim of this study was to retrospectively examine the characteristics of all subjects admitted to the Unit of Infectious Diseases with symptoms indicating H1N1 infection, and to identify any differences between H1N1 positive or negative patients. The purpose of this study was to investigate the potential differences on admission between H1N1 positive and negative patients with flu-like symptoms. These elevated values (C-reactive protein and WBC) are known to be associated with bacterial infection and early antibiotic treatment prevents progression of the disease as reported in previous studies [19] [20] [21] . Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? abstract: BACKGROUND: The World Health Organization alert for the H1N1 influenza pandemic led to the implementation of certain measures regarding admission of patients with flu-like symptoms. All these instructions were adopted by the Greek National Health System. The aim of this study was to retrospectively examine the characteristics of all subjects admitted to the Unit of Infectious Diseases with symptoms indicating H1N1 infection, and to identify any differences between H1N1 positive or negative patients. Patients from the ED (emergency department) with flu-like symptoms (sore throat, cough, rhinorhea, or nasal congestion) and fever >37.5°C were admitted in the Unit of Infectious diseases and gave pharyngeal or nasopharyngeal swabs. Swabs were tested with real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR). FINDINGS: Patients were divided into two groups. Group A comprised 33 H1N1 positive patients and Group B (control group) comprised of 27 H1N1 negative patients. The two groups did not differ in terms of patient age, co-morbidities, length of hospitalization, temperature elevation, hypoxemia, as well as renal and liver function. There were also no significant differences in severity on admission. C-reactive protein (CRP) (mean 12.8 vs. 5.74) and white blood count (WBC) (mean 10.528 vs. 7.114) were significantly higher in group B than in group A upon admission. Obesity was noted in 8 patients of Group A (mean 31.67) and 14 patients of Group B (mean 37.78). Body mass index (BMI) was lower in H1N1 positive than in H1N1 negative patients (mean 31.67 vs. 37.78, respectively; p = 0.009). CONCLUSIONS: The majority of patients in both groups were young male adults. CRP, WBC and BMI were higher among H1N1 negative patients. Finally, clinical course of patients in both groups was mild and uneventful. url: https://www.ncbi.nlm.nih.gov/pubmed/21214902/ doi: 10.1186/1756-0500-4-4 id: cord-026879-gwzrdeb1 author: Zarrintan, Armin title: Rapidly progressive COVID-19 viral pneumonia: a report of two patients with a focus on imaging findings date: 2020-06-16 words: 1748.0 sentences: 103.0 pages: flesch: 53.0 cache: ./cache/cord-026879-gwzrdeb1.txt txt: ./txt/cord-026879-gwzrdeb1.txt summary: CASE PRESENTATION: In the present case report, we discuss two patients who presented with mild symptoms and CT imaging not suggestive of COVID-19, but subsequently had a rapid deterioration, with severe involvement happening in CT imaging. A chest CT scan was obtained from the patient which showed nonspecific findings (few linear and subsegmental atelectasis at lower lobes) which were not suggestive of COVID-19. The patient again presented to the emergency Fig. 1 The first and second rows show the chest CT scan which was obtained at the emergency department, which shows no significant findings consistent with COVID19 except some linear atelectasis. In conclusion, the clinical course of COVID-19 may not follow that of which is presented in available scientific literature, and more attention should be paid to patients not being treated in hospitals, as they can present severe symptoms without any prior radiologic signs. abstract: BACKGROUND: The novel coronavirus causes viral pneumonia characterized by lower respiratory tract symptoms and 19severe inflammatory response syndrome. Studies have suggested that the virus has a clinical course with the stepwise progression of clinical signs and symptoms and radiologic alterations. CASE PRESENTATION: In the present case report, we discuss two patients who presented with mild symptoms and CT imaging not suggestive of COVID-19, but subsequently had a rapid deterioration, with severe involvement happening in CT imaging. One of the patients survived the initial deterioration, but the other passed away. CONCLUSION: We suggest that the clinical course of the virus may be rapidly progressive in some patients, and special attention should be paid to patients being treated for the virus outside of the hospital as an outpatient. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296529/ doi: 10.1186/s43055-020-00225-y id: cord-270799-2pmpspuj author: Zayet, Souheil title: Clinical features of COVID-19 and influenza: A comparative study on Nord Franche-Comte cluster date: 2020-06-16 words: 2849.0 sentences: 167.0 pages: flesch: 57.0 cache: ./cache/cord-270799-2pmpspuj.txt txt: ./txt/cord-270799-2pmpspuj.txt summary: Fever or feeling of fever, fatigue, cough and pain 133 symptoms (myalgia, arthralgia and headache) were the fourth most prevalent symptoms for both 134 diseases (COVID-19 and influenza A/B) without significant statistical differences except for frontal 135 headache and other localization of headache. The onset of 145 these symptoms (from illness onset) didn''t differ between the two groups except for fever which 146 appeared earlier in COVID-19 than in influenza (respectively 1.9 days [±1.5] vs 2.7 days [±1.5], 147 p=0.045). However, we noticed two otorhinolaryngological symptoms recently described 169 with SARS-CoV-2: anosmia and dysgeusia, present in half of our patients. On the other hand, sore throat, conjunctival hyperemia, tearing, sneezing, sputum production, 222 dyspnea, vomiting and rhonchi at pulmonary auscultation were more frequently described in 223 influenza group than COVID-19 group with statistically significant differences. abstract: Clinical descriptions about influenza-like illnesses (ILI) in COVID-19 seem non-specific. We aimed to compare the clinical features of COVID-19 and influenza. We retrospectively investigated the clinical features and outcomes of confirmed cases of COVID-19 and influenza in Nord Franche-Comté Hospital between February 26(th) and March 14(th) 2020. We used SARS-CoV-2 RT-PCR and influenza virus A/B RT-PCR in respiratory samples to confirm the diagnosis. We included 124 patients. The mean age was 59(±19[19-98]) years with 69% female. 70 patients with COVID-19 and 54 patients with influenza A/B. Regarding age, sex and comorbidities, no differences were found between the two groups except a lower Charlson index in COVID-19 group (2[±2.5] vs 3[±2.4],p=0.003). Anosmia (53% vs 17%,p<0.001), dysgeusia (49% vs 20%,p=0.001), diarrhea (40% vs 20%,p=0.021), frontal headache (26% vs 9%,p=0.021) and bilateral cracklings sounds (24% vs 9%,p=0.034) were statistically more frequent in COVID-19. Sputum production (52% vs 29%,p=0.010), dyspnea (59% vs 34%,p=0.007), sore throat (44% vs 20%,p=0.006), conjunctival hyperhemia (30% vs 4%,p<0.001), tearing (24% vs 6%,p=0.004), vomiting (22% vs 3%,p=0.001) and rhonchi sounds (17% vs 1%,p=0.002) were more frequent with influenza infection. We described several clinical differences which can help the clinicians during the co-circulation of influenza and SARS-CoV-2. url: https://api.elsevier.com/content/article/pii/S1286457920300940 doi: 10.1016/j.micinf.2020.05.016 id: cord-027860-s97hdhh6 author: Zeimet, Anthony title: Infectious Diseases date: 2020-06-22 words: 28925.0 sentences: 1728.0 pages: flesch: 45.0 cache: ./cache/cord-027860-s97hdhh6.txt txt: ./txt/cord-027860-s97hdhh6.txt summary: Although common upper respiratory bacterial pathogens, such as Moraxella (Branhamella) catarrhalis, Streptococcus pneumoniae, and Haemophilus influenzae, may be isolated from patients with acute bronchitis, their relevance is questionable because these bacteria can be present in the respiratory tract of healthy individuals. In the treatment of Bordetella pertussis, early administration of a macrolide antibiotic and patient isolation will likely decrease coughing paroxysms and limit spread of disease (Braman, 2006) (SOR: A). Risk factors for Pseudomonas infection include severe structural lung disease (e.g., bronchiectasis) and recent antibiotic therapy, health care-associated exposures or stay in hospital (especially in the ICU). Patients who present with severe infection or whose infection is progressing despite empiric antibiotic therapy should be treated more aggressively; the treatment strategy should be based on results of appropriate Gram stain, culture, and drug susceptibility analysis. For suspected MRSA skin infections, oral treatment options include trimethoprim-sulfamethoxazole, clindamycin, and doxycycline of purulent material when performing incision and drainage in the event that the patient fails to improve and antibiotic coverage becomes necessary. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315328/ doi: 10.1016/b978-1-4377-1160-8.10016-8 id: cord-301281-yur5hs2h author: Zelek, Wioleta M. title: Complement Inhibition with the C5 Blocker LFG316 in Severe COVID-19 date: 2020-11-01 words: 1671.0 sentences: 87.0 pages: flesch: 44.0 cache: ./cache/cord-301281-yur5hs2h.txt txt: ./txt/cord-301281-yur5hs2h.txt summary: We here report the contribution of complement activation and impact of complement blockade in severe COVID-19, defined as marked respiratory impairment requiring intensive care and ventilation support. Five patients were selected, based on high levels of TCC (above the mean 1 2 SD for controls; 7.14 mg/L) and either treatment failure (patients 1-3) or failure to improve (patients 4 and 5) where death was not considered imminent (clinical judgement), for inclusion in a compassionate use study of complement blockade using LFG316 (tesidolumab; Novartis Managed Access Program), a C5-blocking monoclonal antibody (mAb) that prevents generation of the proinflammatory effectors C5a and membrane attack complex (6) . We describe a preliminary evaluation of the potential benefit of C5 blockade in severe COVID-19; we show that the C5-blocking mAb LFG316 could be administered in critically ill mechanically ventilated patients with COVID-19; a single dose of LFG316 blocked C5 activity and complement activation for at least 4 days in all treated patients. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32897730/ doi: 10.1164/rccm.202007-2778le id: cord-296773-5o4hr6ir author: Zeneli, A. title: Mitigating strategies and nursing response for cancer care management during the COVID‐19 pandemic: an Italian experience date: 2020-10-02 words: 4696.0 sentences: 207.0 pages: flesch: 42.0 cache: ./cache/cord-296773-5o4hr6ir.txt txt: ./txt/cord-296773-5o4hr6ir.txt summary: In the early phase of the pandemic, the search of emerging literature was aimed at finding peer-reviewed information needed to keep nursing teams and other healthcare professionals upto-date in the following areas: disease physiopathology and symptoms, ways of person-to-person transmission; evidence or recommendations on infection prevention and control precaution measures; epidemiology, reusable equipment and environmental cleaning procedures, diagnostic tests, efficacy of personal protective equipment (PPE) and communication strategies in healthcare organizations during health emergency events. Patient, caregiver and employee safety, patient health outcomes, use of resources Adopted strategies and instruments for achieving goals Risk assessment to screen those with flu-like symptoms and refer them to their general practitioner for early communication, isolation and treatment for COVID-19 to prevent severe disease; telephone triage of patients before planning their visit to hospital; triaging patients and their caregivers before their access to cancer services; Continuity of essential services, appropriate case management Communication instruments abstract: AIM: To describe our response to the COVID‐19 emergency in a cancer centre to enable other nursing organizations to determine which elements could be useful to manage a surge of patients in their own setting. BACKGROUND: The COVID‐19 pandemic represents one of the most challenging healthcare scenarios faced to date. Managing cancer care in such a complex situation requires a coordinated emergency action plan to guarantee the continuity of cancer treatments for patients by providing healthcare procedures for patients, caregivers and healthcare professionals in a safe environment. PROCEDURES: We describe the main strategies and role of nurses in implementating such procedures. RESULTS: Nurses at our hospital were actively involved in COVID‐19 response defined by the emergency action plan that positively contributed to correct social distancing and to the prevention of the spread of the virus. IMPLICATIONS FOR NURSING AND HEALTH POLICIES: Lessons learned from the response to phase I of COVID‐19 have several implications for future nursing and health policies in which nurses play an active role through their involvement in the frontline of such events. Key policies include a coordinated emergency action plan permitting duty of care within the context of a pandemic, and care pathway revision. This requires the rapid implementation of strategies and policies for a nursing response to the new care scenarios: personnel redistribution, nursing workflow revision, acquisition of new skills and knowledge, effective communication strategies, infection control policies, risk assessment and surveillance programmes, and continuous supplying of personal protective equipment. Finally, within a pandemic context, clear nursing policies reinforcing the role of nurses as patient and caregiver educators are needed to promote infection prevention behaviour in the general population. url: https://doi.org/10.1111/inr.12625 doi: 10.1111/inr.12625 id: cord-275185-9br8lwma author: Zeng, Hao title: The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series date: 2020-10-06 words: 6613.0 sentences: 360.0 pages: flesch: 53.0 cache: ./cache/cord-275185-9br8lwma.txt txt: ./txt/cord-275185-9br8lwma.txt summary: Following CP transfusion, six out of eight patients showed improved oxygen support status; chest CT indicated varying degrees of absorption of pulmonary lesions in six patients within 8 days; the viral load was decreased to a negative level in five patients who had the previous viremia; other laboratory parameters also tended to improve, including increased lymphocyte counts, decreased C-reactive protein, procalcitonin, and indicators for liver function. Herein, we performed a retrospective observational study involving eight critical or severe patients with COVID-19 from four designated hospitals in the southwest region of China, aiming to explore the potential efficacy and safety of CP therapy, and to provide more evidence for the quality control of donated plasma and reasonable clinical application of CP transfusion. 23 Assessing the effects of neutralizing activity of CP on the patients'' clinical efficacy, we found that patients treated by CP with high NAT50 (>1:640) had more obvious improvement than patients receiving low NAT50 value (≤1:640) of CP, including shorter negative conservation time of viral RNA, and higher increment of IgG level after CP transfusion. abstract: Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. However, the quality control of CP and individual variation in patients in different studies make it rather difficult to evaluate the efficacy and risk of CP therapy for coronavirus disease 2019 (COVID-19). We aimed to explore the potential efficacy of CP therapy, and to assess the possible factors associated with its efficacy. We enrolled eight critical or severe COVID-19 patients from four centers. Each patient was transfused with 200–400 mL of CP from seven recovered donors. The primary indicators for clinical efficacy assessment were the changes of clinical symptoms, laboratory parameters, and radiological image after CP transfusion. CP donors had a wide range of antibody levels measured by serology tests which were to some degree correlated with the neutralizing antibody (NAb) level. No adverse events were observed during and after CP transfusion. Following CP transfusion, six out of eight patients showed improved oxygen support status; chest CT indicated varying degrees of absorption of pulmonary lesions in six patients within 8 days; the viral load was decreased to a negative level in five patients who had the previous viremia; other laboratory parameters also tended to improve, including increased lymphocyte counts, decreased C-reactive protein, procalcitonin, and indicators for liver function. The clinical efficacy might be associated with CP transfusion time, transfused dose, and the NAb levels of CP. This study indicated that CP might be a potential therapy for severe patients with COVID-19. url: https://doi.org/10.1038/s41392-020-00329-x doi: 10.1038/s41392-020-00329-x id: cord-352823-1os3kwp1 author: Zeng, Hui title: The strategies of perioperative management in orthopedic department during the pandemic of COVID-19 date: 2020-10-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) has broken out and spread rapidly nationwide at the beginning of 2020, which has brought huge impacts to people and work. The current situation of prevention and control is severe and urges guidance for clinicians, especially for medical systems. In the hope of providing a reference and recommendation for the prevention and control of the COVID-19, we carried out research to improve the quality of patient care and prevention during this epidemic. METHODS: All of the staff were trained rapidly to master personal protection in our department. We reviewed the patients’ discharged records who underwent surgery in our department during January 1 to March 1, 2019, and January 1 to March 1, 2020. The management of the surgery patients and flow charts were described and analyzed. Post-operation outcomes of the patients include duration, complications, surgical site infection (SSI), system infection, re-operation, and mortality. Both chi-squared test and Student’s t test were performed to determine the relationship between the two periods in terms of post-operation outcomes. RESULTS: Descriptive statistics analysis revealed that demographic of the patients between the two periods is similar. We had benefited from the strict flowcharts, smart robot, and protection equipment during the perioperative managements for orthopedic patients. With the help of the strict flow charts and smart equipment, post-operation outcomes of the patients revealed that the rates of the complications and re-operation had been reduced significantly (p < 0.05), while duration of operation, SSI, and system infection had no significant difference between two periods (p > 0.05). No patient and staff caught COVID-19 infection or mortality during the epidemic. CONCLUSIONS: Our study indicated that medical quality and efficiency were affected little with the help of strategies described above during the epidemic, which could be a reference tool for medical staff in routine clinical practice for admission of patients around the world. What is more, the provided strategies, which may evolve over time, could be used as empirical guidance and reference for orthopedic peers to get through the pandemic and ensure the normal operation of the hospital. url: https://www.ncbi.nlm.nih.gov/pubmed/33059739/ doi: 10.1186/s13018-020-01978-y id: cord-252284-cgdcsazr author: Zeng, Jia-Hui title: First case of COVID-19 complicated with fulminant myocarditis: a case report and insights date: 2020-04-10 words: 1988.0 sentences: 124.0 pages: flesch: 50.0 cache: ./cache/cord-252284-cgdcsazr.txt txt: ./txt/cord-252284-cgdcsazr.txt summary: CONCLUSION: COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. Bedside echocardiography showed an enlarged left ventricle (61 mm), diffuse myocardial dyskinesia along with a low left ventricular ejection fraction (LVEF) (32%), pulmonary hypertension (44 mmHg), and no decrease in right cardiac function (Figs. Recently published COVID-19 studies have shown that cardiac complications, including heart failure, arrhythmia and myocardial infarction, are not uncommon, and the proportion of people with increased Trop I in severe cases is higher than other cases [3, 4] . In this case, the patient had the following features: sudden onset, obvious symptoms of viral infection, rapid emergence of severe hemodynamic disorders, severe myocardial injury, and diffuse decreased ventricular wall movement. In this case, the patient had no history of heart disease; therefore, the decreased cardiac function was likely to be caused by COVID-19. COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) has been demonstrated to be the cause of pneumonia. Nevertheless, it has not been reported as the cause of acute myocarditis or fulminant myocarditis. CASE PRESENTATION: A 63-year-old male was admitted with pneumonia and cardiac symptoms. He was genetically confirmed as having COVID-19 according to sputum testing on the day of admission. He also had elevated troponin I (Trop I) level (up to 11.37 g/L) and diffuse myocardial dyskinesia along with a decreased left ventricular ejection fraction (LVEF) on echocardiography. The highest level of interleukin-6 was 272.40 pg/ml. Bedside chest radiographs showed typical ground-glass changes indicative of viral pneumonia. Laboratory test results for viruses that cause myocarditis were all negative. The patient conformed to the diagnostic criteria of the Chinese expert consensus statement for fulminant myocarditis. After receiving antiviral therapy and mechanical life support, Trop I was reduced to 0.10 g/L, and interleukin-6 was reduced to 7.63 pg/mL. Moreover, the LVEF of the patient gradually recovered to 68%. The patient died of aggravation of secondary infection on the 33rd day of hospitalization. CONCLUSION: COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. This is the first report of COVID-19 complicated with fulminant myocarditis. The mechanism of cardiac pathology caused by COVID-19 needs further study. url: https://doi.org/10.1007/s15010-020-01424-5 doi: 10.1007/s15010-020-01424-5 id: cord-288033-9xu1ujcq author: Zeng, Jie title: How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People’s Hospital date: 2020-03-11 words: 431.0 sentences: 37.0 pages: flesch: 56.0 cache: ./cache/cord-288033-9xu1ujcq.txt txt: ./txt/cord-288033-9xu1ujcq.txt summary: Combined with epidemiological history and body temperature screening, if suspected of SARS-CoV-2 infection, they will be admitted to the hospital isolation ward for rapid nucleic acid test. Patients suspected or diagnosed with SARS-CoV-2 infection should be isolated and begin thrombolytic therapy immediately, if within reperfusion time. High-risk patients with contraindications for thrombolysis need to assess the risk of infection and the benefit of PCI. In case of patients within the reperfusion time window and no contraindication to thrombolysis, thrombolytic therapy is performed in an isolation ward. Patients within the reperfusion time window with contraindications for thrombolysis or failure of thrombolysis need to comprehensively evaluate the risks of PCI and infection control. comprehensively evaluate the risks of PCI and infection control. The confirmed case should be transferred to the isolation ward until patient recovery and then it was assessed whether further invasive interventions are needed. abstract: nan url: https://doi.org/10.1007/s00134-020-05993-9 doi: 10.1007/s00134-020-05993-9 id: cord-279790-zzvetjrt author: Zeng, Liujun title: Strategic plan for management in oral and maxillofacial surgery during COVID-19 epidemic date: 2020-04-11 words: 989.0 sentences: 54.0 pages: flesch: 47.0 cache: ./cache/cord-279790-zzvetjrt.txt txt: ./txt/cord-279790-zzvetjrt.txt summary: However, in China, there are still numerous patients with other diseases, especially trauma and cancer requiring surgical treatment. If the oral cancer patient also suffers from COVID-19 or is an asymptomatic virus carrier, check-up and treatment procedures probably cause the spread of the virus through droplets, posing a significant risk to the medical staff. During the epidemic, chemotherapy or radiotherapy can be used as the alternative to surgical treatment in some oral cancer patients. The surgical personnel during operation are required to wear standard personal protection, including N95 masks, disposable protective clothing, disposable shoe covers, goggles or face screen protection. Oral and maxillofacial surgery generally involves the upper respiratory tract, and the surgical site is often contaminated by saliva, so when the electrosurgical equipment is used, powerful suction should be applied to reduce the diffusion of surgical smoke and aerosols. Moreover, for novel coronavirus-infected patients including asymptomatic virus carriers, the virus can spread through splashing of respiratory secretions when the patients cough. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32305309/ doi: 10.1016/j.oraloncology.2020.104715 id: cord-268531-igjeai8c author: Zerah, Lorène title: Clinical Characteristics and Outcomes of 821 Older Patients With SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards: A Multicenter Retrospective Cohort Study date: 2020-08-26 words: 4030.0 sentences: 210.0 pages: flesch: 46.0 cache: ./cache/cord-268531-igjeai8c.txt txt: ./txt/cord-268531-igjeai8c.txt summary: title: Clinical Characteristics and Outcomes of 821 Older Patients With SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards: A Multicenter Retrospective Cohort Study On multivariate analysis, at COVID-19 onset, the probability of in-hospital mortality was increased with male gender (odds ratio [OR] 1.85; 95% CI 1.30–2.63), ADL score <4 (OR 1.84; 95% CI 1.25–2.70), asthenia (OR 1.59; 95% CI 1.08–2.32), quick Sequential Organ Failure Assessment score ≥2 (OR 2.63; 95% CI 1.64–4.22), and specific COVID-19 anomalies on chest computerized tomography (OR 2.60; 95% CI 1.07–6.46). Although age has been widely reported as a major risk factor for severe COVID-19 and death, no large geriatric cohort of older patients hospitalized in a geriatric ward has been described. The objective of this multicentric French retrospective study was to describe the clinical characteristics and outcomes of a large cohort of older patients with confirmed COVID-19 who were admitted to acute care geriatric wards and to determine the prognostic factors of in-hospital mortality. abstract: BACKGROUND: There is limited information describing the characteristics and outcomes of hospitalized older patients with confirmed coronavirus disease 2019 (COVID-19). METHOD: We conducted a multicentric retrospective cohort study in 13 acute COVID-19 geriatric wards, from March 13 to April 15, 2020, in Paris area. All consecutive patients aged 70 years and older, with confirmed COVID-19, were enrolled. RESULTS: Of the 821 patients included in the study, the mean (SD) age was 86 (7) years; 58% were female; 85% had ≥2 comorbidities; 29% lived in an institution; and the median [interquartile range] Activities of Daily Living scale (ADL) score was 4 [2–6]. The most common symptoms at COVID-19 onset were asthenia (63%), fever (55%), dyspnea (45%), dry cough (45%), and delirium (25%). The in-hospital mortality was 31% (95% confidence interval [CI] 27–33). On multivariate analysis, at COVID-19 onset, the probability of in-hospital mortality was increased with male gender (odds ratio [OR] 1.85; 95% CI 1.30–2.63), ADL score <4 (OR 1.84; 95% CI 1.25–2.70), asthenia (OR 1.59; 95% CI 1.08–2.32), quick Sequential Organ Failure Assessment score ≥2 (OR 2.63; 95% CI 1.64–4.22), and specific COVID-19 anomalies on chest computerized tomography (OR 2.60; 95% CI 1.07–6.46). CONCLUSIONS: This study provides new information about older patients with COVID-19 who are hospitalized. A quick bedside evaluation at admission of sex, functional status, systolic arterial pressure, consciousness, respiratory rate, and asthenia can identify older patients at risk of unfavorable outcomes. url: https://www.ncbi.nlm.nih.gov/pubmed/32845301/ doi: 10.1093/gerona/glaa210 id: cord-281106-vzb5xzza author: Zerwes, S. title: COVID-19-Infektion – Risiko für thrombembolische Komplikationen date: 2020-09-01 words: 1929.0 sentences: 204.0 pages: flesch: 38.0 cache: ./cache/cord-281106-vzb5xzza.txt txt: ./txt/cord-281106-vzb5xzza.txt summary: According to current data, the risk of thromboembolic events in hospitalized COVID-19 patients is significantly increased, making thrombosis prophylaxis with low molecular weight or unfractionated heparin necessary. Neben den bekannten Ursachen der Thromboseentstehung, wurden bei der COVID-Erkrankung spezielle Pathomechanismen beobachtet, die zur Bildung von Thrombosen sowohl im venösen als auch im arteriellen System beitragen können. Auch wenn die Mechanismen noch nicht in Ihrer Gesamtheit erfasst sind, so ist bereits jetzt ersichtlich, dass die thrombembolischen Komplikationen im Zusammenhang mit dem SARS-CoV-2-Virus auf eine exzessive Inflammationsreaktion, Veränderung von Blutflusseigenschaften, direkte virusbedingte Thrombozytenaktivierung und Endothelschädigung zurückzuführen sind [3] . Diese Hypothese wird von nahezu allen bisher publizierten Arbeiten zu thrombembolischen Ereignissen bei COVID-19-Patienten postuliert und könnte eine Erklärung für die deutlich erhöhte Anzahl von TVT bieten [1, 7, 17, 28, 39] . Eine einheitliche Nomenklatur besteht noch nicht, die Pu-blikationmitdergrößtenSerie benennt es als "Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2" (PIMS-TS) [36] . abstract: While the COVID-19 syndrome triggered by the SARS CoV‑2 was initially seen predominantly as a pulmonary disease, the number of reports of vascular complications has recently increased. The aim of the present review article is to summarize the most relevant vascular complications in COVID-19 patients. These include venous and arterial thromboembolic events as well as local thromboses, which can form directly on the endothelium at the site of cytokine release. A generalized coagulopathy also appears to promote this thrombogenic condition. With a rate of approximately 20%, deep vein thrombosis (DVT) of the leg is one of the most common thromboembolic events in COVID-19 patients requiring intensive care treatment. In addition, arterial events, such as stroke or acute coronary syndrome were also observed in COVID-19 patients with pre-existing vascular disease. Children rarely have vascular complications, but a systemic immune response similar to the Kawasaki syndrome and toxic shock syndrome has been reported. According to current data, the risk of thromboembolic events in hospitalized COVID-19 patients is significantly increased, making thrombosis prophylaxis with low molecular weight or unfractionated heparin necessary. If pharmaceutical thrombosis prophylaxis is contraindicated, intermittent pneumatic compression should be used. In addition, in patients admitted to the hospital with suspected or proven SARS-CoV‑2 infection, the determination of D‑dimers and, in the case of positive results, broad indication for compression sonography of the deep leg veins are recommended. This allows to detect and treat DVT at an early stage. The treatment of thromboses should be carried out according to current guidelines with therapeutic anticoagulation. Further studies and registries are needed to improve the understanding of the relationship between COVID-19 infection and the occurrence of thromboembolic events. url: https://www.ncbi.nlm.nih.gov/pubmed/32905019/ doi: 10.1007/s00772-020-00687-4 id: cord-339885-mpzgrogd author: Zhan, Yangqing title: Respiratory virus is a real pathogen in immunocompetent community-acquired pneumonia: comparing to influenza like illness and volunteer controls date: 2014-09-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Viral pathogens were more commonly reported than previously estimated in community-acquired pneumonia (CAP) patients. However, the real role of virus was still controversial. METHODS: Consecutive adult patients with CAP between April and December, 2009 were prospectively enrolled. A four-fold or greater increase of IgG-titres against respiratory viruses in pair sera was tested by means of hemagglutination inhibition assay or indirect immunofluorescence. Swab samples were tested by cell culture and/or nucleic amplification tests. Viral etiology was considered definitive if at least one of the above tests was positive. RESULTS: Viral etiology was established in fifty-two (34.9%) of 149 CAP patients, twenty-two (81.5%) of 27 influenza like illness patients, and none of 75 volunteer controls. Forty-seven CAP patients were infected by a single virus (24 influenza A virus, 5 influenza B, 10 parainfluenza virus type 3 [PIV-3], 2 PIV-1, 2 adenovirus, 2 human rhinovirus and 2 coronavirus OC43), five cases by two or three viruses co-infection. Fever ≥ 39°C (66.7%), fatigue (64.6%), and purulent sputum (52.1%) was the most common symptoms in viral pneumonia patients. On multivariate analysis, myalgia was included in the model for pneumonia associated with influenza infection. In the CURB-65 model only influenza infection was found independently associated with severe disease (CURB-65 score ≥ 3) out of variables, including age(years), sex, current smoking status, sick contact with febrile patients, numbers of comorbidity, presence of influenza infection, presence of PIV infection, with P = 0.021, OR 7.86 (95% CI 1.37-45.04). CONCLUSION: Respiratory virus was not a bystander, but pathogenic in pneumonia and was a common cause of CAP. url: https://www.ncbi.nlm.nih.gov/pubmed/25178477/ doi: 10.1186/1471-2466-14-144 id: cord-252288-klkoerfn author: Zhang, Bicheng title: Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19 date: 2020-07-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction: A recently emerging respiratory disease named coronavirus disease 2019 (COVID-19) has quickly spread across the world. This disease is initiated by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and uncontrolled cytokine storm, but it remains unknown as to whether a robust antibody response is related to clinical deterioration and poor outcome in COVID-19 patients. Methods: Anti-SARS-CoV-2 IgG and IgM antibodies were determined by chemiluminescence analysis (CLIA) in COVID-19 patients at a single center in Wuhan. Median IgG and IgM levels in acute and convalescent-phase sera (within 35 days) for all included patients were calculated and compared between severe and non-severe patients. Immune response phenotyping based on the late IgG levels and neutrophil-to-lymphocyte ratio (NLR) was characterized to stratified patients into different disease severities and outcomes. Results: A total of 222 patients were included in this study. IgG was first detected on day 4 of illness, and its peak levels occurred in the fourth week. Severe cases were more frequently found in patients with high IgG levels, compared to those with low IgG levels (51.8 vs. 32.3%; p = 0.008). Severity rates for patients with NLR(hi)IgG(hi), NLR(hi)IgG(lo), NLR(lo)IgG(hi), and NLR(lo)IgG(lo) phenotype were 72.3, 48.5, 33.3, and 15.6%, respectively (p < 0.0001). Furthermore, severe patients with NLR(hi)IgG(hi), NLR(hi)IgG(lo) had higher inflammatory cytokines levels including IL-2, IL-6 and IL-10, and decreased CD4+ T cell count compared to those with NLR(lo)IgG(lo) phenotype (p < 0.05). Recovery rates for severe patients with NLR(hi)IgG(hi), NLR(hi)IgG(lo), NLR(lo)IgG(hi), and NLR(lo)IgG(lo) phenotype were 58.8% (20/34), 68.8% (11/16), 80.0% (4/5), and 100% (12/12), respectively (p = 0.0592). Dead cases only occurred in NLR(hi)IgG(hi) and NLR(hi)IgG(lo) phenotypes. Conclusions: COVID-19 severity is associated with increased IgG response, and an immune response phenotyping based on the late IgG response and NLR could act as a simple complementary tool to discriminate between severe and non-severe COVID-19 patients, and further predict their clinical outcome. url: https://doi.org/10.3389/fmolb.2020.00157 doi: 10.3389/fmolb.2020.00157 id: cord-253456-u9num2o9 author: Zhang, Che title: Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series date: 2020-06-16 words: 4540.0 sentences: 260.0 pages: flesch: 49.0 cache: ./cache/cord-253456-u9num2o9.txt txt: ./txt/cord-253456-u9num2o9.txt summary: Suspected patients with clinical and/or radiological features of pneumonia were quarantined prior to SARS-CoV-2 nucleic acid detection according to WHO guidelines for cases with suspected infection [8] as well as the instructions from the Pediatric Branch of the Hubei Medical Association for pediatric cases [9] . Specifically, suspected cases of SARS-CoV-2 infection should meet 1 of the following criteria [10] : (1) at least 1 clinical symptom, including fever, expectation, tachypnea, lethargy, poor feeding, cough, vomiting, and diarrhea; (2) chest radiologic abnormalities consistent with viral pneumonia. Patients were discharged when all the following criteria were met [10] : (1) fever had recovered for at least 3 days; (2) upper respiratory symptoms were alleviated; (3) the exudative lesion was alleviated significantly according to radiological evidence; (4) negative results were obtained for SARS-CoV-2 nucleic acid detection in 2 consecutive tests performed with an interval of 24 hours. abstract: BACKGROUND: As of April 18, 2020, over 2,000,000 patients had been diagnosed with coronavirus disease-2019 (COVID-19) globally, and more than 140,000 deaths had been reported. The clinical and epidemiological characteristics of adult patients have been documented recently. However, information on pediatric patients is limited. We describe the clinical and epidemiological characteristics of pediatric patients to provide valuable insight into the early diagnosis and assessment of COVID-19 in children. METHODS AND FINDINGS: This retrospective, observational study involves a case series performed at 4 hospitals in West China. Thirty-four pediatric patients with COVID-19 were included from January 27 to February 23, 2020. The final follow-up visit was completed by March 16, 2020. Clinical and epidemiological characteristics were analyzed on the basis of demographic data, medical history, laboratory tests, radiological findings, and treatment information. Data analysis was performed for 34 pediatrics patients with COVID-19 aged from 1 to 144 months (median 33.00, interquartile range 10.00–94.25), among whom 14 males (41%) were included. All the patients in the current study presented mild (18%) or moderate (82%) forms of COVID-19. A total of 48% of patients were noted to be without a history of exposure to an identified source. Mixed infections of other respiratory pathogens were reported in 16 patients (47%). Comorbidities were reported in 6 patients (18%). The most common initial symptoms were fever (76%) and cough (62%). Expectoration (21%), vomiting (12%), and diarrhea (12%) were also reported in a considerable portion of cases. A substantial increase was detected in serum amyloid A for 17 patients (among 20 patients with available data; 85%) and in high-sensitivity C-reactive protein for 17 patients (among 29 patients with available data; 59%), whereas a decrease in prealbumin was noticed in 25 patients (among 32 patients with available data; 78%). In addition, significant increases in the levels of lactate dehydrogenase and α-hydroxybutyrate dehydrogenase were detected in 28 patients (among 34 patients with available data; 82%) and 25 patients (among 34 patients with available data; 74%), respectively. Patchy lesions in lobules were detected by chest computed tomographic scans in 28 patients (82%). Ground-glass opacities, which were a typical feature in adults, were rare in pediatric patients (3%). Rapid radiologic progression and a late-onset pattern of lesions in the lobules were also noticed. Lesions in lobules still existed in 24 (among 32 patients with lesions; 75%) patients that were discharged, although the main symptoms disappeared a few days after treatment. All patients were discharged, and the median duration of hospitalization was 10.00 (8.00–14.25) days. The current study was limited by the small sample size and a lack of dynamic detection of inflammatory markers. CONCLUSIONS: Our data systemically presented the clinical and epidemiological features, as well as the outcomes, of pediatric patients with COVID-19. Stratified analysis was performed between mild and moderate cases. The findings offer new insight into early identification and intervention in pediatric patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32544155/ doi: 10.1371/journal.pmed.1003130 id: cord-016237-sk1wzghx author: Zhang, Chen title: Infectious Diseases date: 2018-09-07 words: 1491.0 sentences: 96.0 pages: flesch: 29.0 cache: ./cache/cord-016237-sk1wzghx.txt txt: ./txt/cord-016237-sk1wzghx.txt summary: Patients with life-threatening pneumonia, especially those who are immunocompromised, are more likely to undergo lung biopsy to rule out unusual infections not easily diagnosed using conventional microbiologic methods and for which treatment strategies may be different. Nocardiosis ( Fig. 4 .5) occurs almost exclusively in immunocompromised patients and is caused by a gram-positive filamentous organism (Nocardia spp.) common in soil and as normal oral microflora. Some viral infections cause unique cytopathic changes that can be identified on routinely stained sections (Figs. Fungal infections more commonly seen in immunologically intact hosts may also occur in immunocompromised patients in whom the histologic findings may be more variable. It causes disease in both immunocompetent and immunocompromised patients and may be biopsied or excised because of its tendency to form a localized lung nodule. Pneumocystis pneumonia is affiliated with highly variable histologic features and therefore should always be in the differential diagnosis of infections in immunocompromised patients. abstract: Pulmonary infections are caused by a wide range of pathogenic microorganisms, including bacteria, viruses, fungi, and parasites. The most common lung infections in immunocompetent hosts are caused by pyogenic bacteria (e.g., Streptococcus pneumoniae), common respiratory viruses, and mycoplasma. These infections are usually diagnosed by clinical and microbiologic studies, including cultures and serology tests. Lung biopsy is rarely used in these diagnoses. Patients with life-threatening pneumonia, especially those who are immunocompromised, are more likely to undergo lung biopsy to rule out unusual infections not easily diagnosed using conventional microbiologic methods and for which treatment strategies may be different. Pathogens more likely to be diagnosed using lung biopsy for which there are characteristic pathologic changes are highlighted in this chapter and listed in Table 4.1. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120464/ doi: 10.1007/978-1-4939-8689-7_4 id: cord-262973-mydn7ver author: Zhang, Dekang title: Experts Consensus on Epidemic Prevention and Control in Radiotherapy Centers during the COVID-19 Outbreak: Experiences from Sichuan Province date: 2020-06-30 words: 2652.0 sentences: 149.0 pages: flesch: 53.0 cache: ./cache/cord-262973-mydn7ver.txt txt: ./txt/cord-262973-mydn7ver.txt summary: In order to minimize the adverse impact of this unexpected epidemic on patients who need radiotherapy, the expert group of our radiotherapy center immediately formulated comprehensive emergency plans and prevention and control measures, partitioned the work area, launched online staff training, and optimized the radiotherapy process after the outbreak, which provided a strong guarantee for the safe and orderly operation of our radiotherapy center and kept the infection rate to an extremely low level. Patients need to perform hand hygiene disinfection and wear masks and overshoes correctly, every time they enter the radiotherapy center. To minimize the risk of cross-infection, radiotherapy centers should adjust entrances and exits to separate patient passages from medical staff passages and form a one-way channel in the internal area if possible. The level III area, such as the operator room of the accelerator, is where medical staff go after contact with patients and is classified as intermediate risk. abstract: After the outbreak of COVID-19, medical institutions in China and even around the world are facing unprecedented challenges. In order to minimize the adverse impact of this unexpected epidemic on patients who need radiotherapy, the expert group of our radiotherapy center immediately formulated comprehensive emergency plans and prevention and control measures, partitioned the work area, launched online staff training, and optimized the radiotherapy process after the outbreak, which provided a strong guarantee for the safe and orderly operation of our radiotherapy center and kept the infection rate to an extremely low level. We hope our experience could provide reference and suggestions for other medical institutions. url: https://doi.org/10.1016/j.ctro.2020.06.010 doi: 10.1016/j.ctro.2020.06.010 id: cord-285755-zblitbo0 author: Zhang, F. title: Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study date: 2020-03-24 words: 3069.0 sentences: 164.0 pages: flesch: 42.0 cache: ./cache/cord-285755-zblitbo0.txt txt: ./txt/cord-285755-zblitbo0.txt summary: [Results] A total of 110 patients with confirmed (n=80) or suspected (n=30) COVID-19 were screened and 48 patients (female 31.3%, mean age 70.58{+/-}13.38 year old) among them with high-sensitivity cardiac troponin I (hs-cTnI) test within 48 hours after admission were included, of whom 17 (17/48, 35.4%) died in hospital while 31 (31/48, 64.6%) were discharged or transferred to other hospital. [Conclusions] Cardiac injury defined by hs-cTnI elevation and elevated d-dimer on admission were risk factors for in-hospital death, while higher SpO2 could be seen as a protective factor, which could help clinicians to identify patients with adverse outcome at the early stage of COVID-19. Short-term prognosis of COVID-19 patients are discrepancy and in-hospital mortality risk are high in severe cases[1] [2] Although previous study had indicated that several risk factors were independently associated with short-term mortality, such as elevated d-dimer, older age and higher Sequential Organ Failure Assessment (SOFA) score [2] , few studies focused on cardiac injury with COVID-19 patients. abstract: [Background] Since December 2019, a cluster of coronavirus disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China and spread rapidly from China to other countries. In-hospital mortality are high in severe cases and cardiac injury characterized by elevated cardiac troponin are common among them. The mechanism of cardiac injury and the relationship between cardiac injury and in-hospital mortality remained unclear. Studies focused on cardiac injury in COVID-19 patients are scarce. [Objectives] To investigate the association between cardiac injury and in-hospital mortality of patients with confirmed or suspected COVID-19. [Methods] Demographic, clinical, treatment, and laboratory data of consecutive confirmed or suspected COVID-19 patients admitted in Wuhan No.1 Hospital from 25th December, 2019 to 15th February, 2020 were extracted from electronic medical records and were retrospectively reviewed and analyzed. Univariate and multivariate Cox regression analysis were used to explore the risk factors associated with in-hospital death. [Results] A total of 110 patients with confirmed (n=80) or suspected (n=30) COVID-19 were screened and 48 patients (female 31.3%, mean age 70.58{+/-}13.38 year old) among them with high-sensitivity cardiac troponin I (hs-cTnI) test within 48 hours after admission were included, of whom 17 (17/48, 35.4%) died in hospital while 31 (31/48, 64.6%) were discharged or transferred to other hospital. High-sensitivity cardiac troponin I was levated in 13 (13/48, 27.1%) patents. Multivariate Cox regression analysis showed pulse oximetry of oxygen saturation (SpO2) on admission (HR 0.704, 95% CI 0.546-0.909, per 1% decrease, p=0.007), elevated hs-cTnI (HR 10.902, 95% 1.279-92.927, p=0.029) and elevated d-dimer (HR 1.103, 95%CI 1.034-1.176, per 1mg/L increase, p=0.003) on admission were independently associated with in-hospital mortality. [Conclusions] Cardiac injury defined by hs-cTnI elevation and elevated d-dimer on admission were risk factors for in-hospital death, while higher SpO2 could be seen as a protective factor, which could help clinicians to identify patients with adverse outcome at the early stage of COVID-19. url: http://medrxiv.org/cgi/content/short/2020.03.21.20040121v1?rss=1 doi: 10.1101/2020.03.21.20040121 id: cord-327432-ogw27tob author: Zhang, Feng-jian title: Expert Consensus on Nurses’ Human Caring for COVID-19 Patients in Different Sites date: 2020-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This study aims to develop the expert consensus on nurse’s human caring for Corona Virus Disease 2019 (COVID-19) patients in different sites, and thus provide a guideline on providing whole process and systematic caring for COVID-19 patients. Based on the frontline experiences of human caring for COVID-19 patients and the review of literature, the initial draft of consensus was made and finalized after online meeting and revisions. The experts reached consensus on the following parts: terms and definitions, principles of human caring for COVID-19 patients, and human caring measures for COVID-19 patients in different sites. The expert consensus is practical, concise, and reasonable for guiding the nurses providing human caring for COVID-19 patients, as well as other similar infectious diseases. url: https://doi.org/10.1007/s11596-020-2222-0 doi: 10.1007/s11596-020-2222-0 id: cord-327397-8rxjju0t author: Zhang, H.-Y. title: A Multicentre Study of 2019 Novel Coronavirus Disease Outcomes of Cancer Patients in Wuhan, China date: 2020-03-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: At present, there is a global pandemic of coronavirus disease 2019 (COVID-19) pneumonia. Two previous case series from China have suggested that cancer patients are at a higher risk of COVID-19 pneumonia, but the reports were limited by small numbers and few clinical information. Objective: To study clinical characteristics and outcomes of cancer patients infected with COVID-19. Design: Retrospective study. Setting: Four designated COVID-16 hospitals in Wuhan, Hubei province, China. Participants: Medical records of 67 cancer patients admitted to hospitals between Jan 5, 2020 to Feb 18, 2020 were included. Measurements: Demographic, clinical, laboratory, radiological and treatment data were collected. Survival data of the cohort was cut-off on Mar 10, 2020. Results: Of the 67 patients (median age: 66 years), the median age of patients who had severe illness was older than that of patients who had mild symptoms (P<0.001). Forty-three (64.2%) patients had other concurrent chronic diseases, and the proportion of severe patients had co-morbidities was higher than patients with mild disease (P=0.004). Twenty-three (34.3%) patients were still at the anticancer treatment phase, but no tumour progression and recurrence was observed for all the patients during the treatment of COVID-19 pneumonia. About 70% of these patients had fever (n=53, 79.1%) and/or cough (n=50, 74.6%). Lymphocytopenia was the main laboratory finding accompanying increased C-reactive protein and procalcitonin in cancer patients, especially in severe cases. By Mar 10, 2020, 18 (26.9%) patients died from COVID-19, and 39 (58.2%) patients have been discharged. The median age of survivors was younger than that of deaths (P=0.014). Lung cancer (n=15, 22.4%) with COVID-19 was the most common cancer type and accounted for the highest proportion COVID-19 resulted deaths (33.3%, 5/15). We observed a tendency that patients at the follow-up phase had a better prognosis than that at anticancer treatment phase (P=0.095). Limitation: This is a retrospective study with only 67 cases from four hospitals. And some specific clinical information was insufficient. Conclusion: This study showed COVID-19 patients with cancer seem to have a higher proportion of severe cases and poorer prognosis. The tendency of poor prognosis was more obvious in patients at anticancer treatment phase. We should pay more intensive attentions to cancer patients infected with COVID-19. url: https://doi.org/10.1101/2020.03.21.20037127 doi: 10.1101/2020.03.21.20037127 id: cord-277430-x02u7oh0 author: Zhang, Hongyan title: Outcomes of novel coronavirus disease 2019 (COVID‐19) infection in 107 patients with cancer from Wuhan, China date: 2020-06-23 words: 3182.0 sentences: 157.0 pages: flesch: 44.0 cache: ./cache/cord-277430-x02u7oh0.txt txt: ./txt/cord-277430-x02u7oh0.txt summary: Secondary analyses included the reporting of clinical presentation and outcomes based on the different cancer types, and the association between mortality due to COVID-19 and whether the patient was receiving ongoing active anticancer treatment (systemic therapy, local therapy, or a combination). 5, 16 Rather, in the current study cohort of 107 patients, we observed that active anticancer treatment within 1 month of a diagnosis of COVID-19 was associated with profound lymphopenia (median of 0.55 vs 1.05 for those on follow-up) and markedly elevated inflammatory markers of C-reactive protein (36.00 vs 27.40) and procalcitonin (0.17 vs 0.06). The results of the current study demonstrated the clinical characteristics and outcomes of COVID-19 in a large cohort of 107 patients with different cancer types, and suggested a high incidence of severe illness and case fatality rates compared with the community population. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. abstract: BACKGROUND: Patients with cancer have a higher risk of coronavirus disease 2019 (COVID‐19) than noncancer patients. The authors conducted a multicenter retrospective study to investigate the clinical manifestations and outcomes of patients with cancer who are diagnosed with COVID‐19. METHODS: The authors reviewed the medical records of hospitalized patients who were treated at 5 hospitals in Wuhan City, China, between January 5 and March 18, 2020. Clinical parameters relating to cancer history (type and treatment) and COVID‐19 were collected. The primary outcome was overall survival (OS). Secondary analyses were the association between clinical factors and severe COVID‐19 and OS. RESULTS: A total of 107 patients with cancer were diagnosed with COVID‐19, with a median age of 66 years (range, 37‐98 years). Lung (21 patients; 19.6%), gastrointestinal (20 patients; 18.7%), and genitourinary (20 patients; 18.7%) cancers were the most common cancer diagnoses. A total of 37 patients (34.6%) were receiving active anticancer treatment when diagnosed with COVID‐19, whereas 70 patients (65.4%) were on follow‐up. Overall, 52.3% of patients (56 patients) developed severe COVID‐19; this rate was found to be higher among patients receiving anticancer treatment than those on follow‐up (64.9% vs 45.7%), which corresponded to an inferior OS in the former subgroup of patients (hazard ratio, 3.365; 95% CI, 1.455‐7.782 [P = .005]). The detrimental effect of anticancer treatment on OS was found to be independent of exposure to systemic therapy (case fatality rate of 33.3% [systemic therapy] vs 43.8% [nonsystemic therapy]). CONCLUSIONS: The results of the current study demonstrated that >50.0% of infected patients with cancer are susceptible to severe COVID‐19. This risk is aggravated by simultaneous anticancer treatment and portends for a worse survival, despite treatment for COVID‐19. url: https://www.ncbi.nlm.nih.gov/pubmed/32573776/ doi: 10.1002/cncr.33042 id: cord-346241-w076l97s author: Zhang, Hua title: Dynamic CT assessment of disease change and prognosis of patients with moderate COVID-19 pneumonia date: 2020-09-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: To assess prognosis or dynamic change from initial diagnosis until recovery of the patients with moderate coronavirus disease (COVID-19) pneumonia using chest CT images. MATERIALS AND METHODS: In this retrospective study, 33 patients (18 men, 15 women; median age, 49.0 years) with confirmed with moderate COVID-19 pneumonia in a multicenter hospital were included. The patients underwent at least four chest non-contrast-enhanced computed tomography (CT) scans at approximately 5-day intervals. We analyzed the clinical and CT characteristics of the patients. Moreover, the total CT score and the sum of lung involvement were determined for every CT scan. RESULTS: The most widespread presenting symptoms were fever (32/33, 97.0%) and cough (17/33, 51.5%), which were often accompanied by decreased lymphocyte count (15/33, 45.5%) and increased C-reactive protein levels (18/33, 54.6%). Bilateral, multifocal ground glass opacities (32/33, 97.0%), consolidation (25/33, 75.8%), vascular thickening (23/33, 69.7%), and bronchial wall thickening (21/33, 63.6%) with peripheral distribution were the most frequent CT findings during moderate COVID-19 pneumonia. In patients recovering from moderate COVID-19 pneumonia, four stages (stages 1–4) of evolution were identified on chest CT with average CT scores of 3.4±2.3, 6.0±4.4, 5.6±3.8, and 4.9±3.2, respectively, from the onset of symptoms. For most patients, the peak of average total CT score increased for approximately 8 days after the onset of symptoms, after which it decreased gradually. The mean CT score of all patients was 4.7 at the time of discharge. CONCLUSION: The moderate COVID-19 pneumonia CT score increased rapidly in a short period of time initially, followed by a slow decline over a relatively long time. The peak of the course occurred in stage 2. Complete recovery of patients with moderate COVID-19 pneumonia with high mean CT score at the time of discharge requires longer time. url: https://www.ncbi.nlm.nih.gov/pubmed/32741802/ doi: 10.3233/xst-200711 id: cord-348672-e34103b1 author: Zhang, Jiaqi title: Postoperative Short-term Outcomes Between Sublobar Resection and Lobectomy in Patients with Lung Adenocarcinoma date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: To investigate postoperative temporary consequences of the enrolled patients with lung adenocarcinoma. PATIENTS AND METHODS: We analyzed the clinical data of patients with lung adenocarcinoma admitted by the same surgical team of Peking Union Medical College Hospital (PUMCH) from July 2019 to December 2019. Statistical methods including propensity score matching (PSM) analysis was used to analyze the differences among them. RESULTS: A total of 108 patients were enrolled, including 50 patients with sublobar resection and 58 patients with lobectomy. Before PSM, there were statistically significant differences in age (p=0.015), hospitalization costs (p=0.042), lymphadenectomy (p=0.000), pathological staging (p=0.000), number of lymph nodes removed (p=0.000), number of positive lymph nodes (p=0.034), chest drainage duration (p=0.000), total chest drainage (p=0.000), length of postoperative hospital stays (p=0.000), postoperative D-dimer level (p=0.030) and perioperative lymphocyte margin (LM) (p=0.003) between sublobar resection and lobectomy. After PSM, there were statistical differences in number of lymph nodes removed (p=0.000), chest drainage duration (p=0.031) and total chest drainage (p=0.002) between sublobar resection and lobectomy. Whether with PSM analysis or not, there were no significant differences in other blood test results, such as inflammation indicators, postoperative neutrophil-lymphocyte ratio (NLR), albumin level, perioperative activity of daily living (ADL) scale scoring margin, complications, postoperative admission to intensive care unit (ICU) and readmission within 30 days. NLR was associated with total chest drainage (p=0.000), length of postoperative hospital stays (p=0.000), postoperative D-dimer level (p=0.050) and ADL scale scoring margin (p=0.003) between sublobar resection and lobectomy. CONCLUSION: Sublobar resection, including wedge resection and segmentectomy, was as safe and feasible as lobectomy in our study, and they shared similar short-term outcomes. Postoperative NLR could be used to detect the clinical outcomes of patients. Secondary resectability of pulmonary function (SRPF) should be the main purpose of sublobar resection. url: https://doi.org/10.2147/cmar.s266376 doi: 10.2147/cmar.s266376 id: cord-343023-e1uv7t6p author: Zhang, Jingchen title: Failure of early extubation among cases of coronavirus disease-19 respiratory failure: Case report and clinical experience date: 2020-07-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: RATIONALE: Extubation strategy for mechanically ventilated patients with Coronavirus Disease 19 is different from that for patients with other viral pneumonia. We reported 2 cases of Coronavirus Disease 19 receiving tracheal intubation twice during the hospitalization. PATIENT CONCERNS: Two elderly patients with onset of fever and upper respiratory tract infection were confirmed as Coronavirus Disease 19, 1 of whom had chronic obstructive pulmonary disease previously. With active antiviral and noninvasive respiratory supportive therapy, there was no improvement, thus mechanical ventilation (MV) was adopted. Combining with symptomatic and supportive treatment, their oxygenation recovered and then extubation was carried out. However, 96 hours later, they underwent endotracheal intubation again due to their Coronavirus Disease 19 progression. DIAGNOSIS: Critically ill Coronavirus Disease 19 requiring tracheal intubation owing to respiratory failure with lung.javascript. INTERVENTIONS: Initial Strategy for respiratory failure included endotracheal intubation, MV, antiviral treatment and cortisol in both cases. When extubation criteria were satisfied, early discontinuation of MV was conducted, then rehabilitation exercise and nutritional support followed. However, 96 hours later, the disease progressed leading to respiratory failure again, thus reintubation was performed. Later, veno-venous extracorporeal membrane oxygenation was performed owing to aggravation of respiratory failure, assisted by prone position treatment and sputum drainage, then status became stable and stepped into recovery stage. OUTCOMES: Both patients underwent reintubation, and their MV time and Intensive care unit residence time were prolonged. Through prone position treatment, sputum drainage and awake extracorporeal membrane oxygenation strategy, patient has been transferred to rehabilitation unit in Case 1, and patient in Case 2 has been in recovery stage as well with stable pulmonary status and was expected to receive evaluation in recent future. LESSONS: Course of Coronavirus Disease 19 is relatively longer, and failure rate of simple early extubation seemes higher. To reduce the likelihood of reintubation and iatrogenic injury, individualized assessment is recommended. url: https://doi.org/10.1097/md.0000000000020843 doi: 10.1097/md.0000000000020843 id: cord-012778-yr8zuvw9 author: Zhang, Lei title: Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China date: 2019-08-06 words: 5055.0 sentences: 262.0 pages: flesch: 46.0 cache: ./cache/cord-012778-yr8zuvw9.txt txt: ./txt/cord-012778-yr8zuvw9.txt summary: We quantified the time course of PSP improvement in patients after treatment with these three antipsychotics: olanzapine, risperidone, and aripiprazole reached an E(max) value of 80.3%, 68.2%, and 23.9% at weeks 56.7, 29.2, and 36.8, respectively. In addition, quantitative information on the long-term social functioning of schizophrenic patients treated with SGAs is scarce in current clinical practice [12, 13] , and the available information does not reflect the differences in therapeutic efficacies between various drugs. Using data from the Study of Long-term Outcomes for Schizophrenia by Atypical Antipsychotic Treatment in China (SALT-C) study, which is a multicenter, real-world clinical study, we examined the differences in efficacy between three antipsychotics (olanzapine, risperidone, and aripiprazole) to provide a guide for clinicians when choosing an antipsychotic for the individualized treatment of schizophrenia. The SALT-C study was registered at https://www.clinicaltrials.gov (identifier: NCT02640911) and produced a large data set of real-world schizophrenia patients in China recruited in an open-label 3-year follow-up clinical trial of widely used atypical antipsychotics. abstract: Atypical antipsychotics exert remarkable long-term efficacy on the personal and social functions of schizophrenic patients. However, quantitative information on the social function of schizophrenic patients treated with atypical antipsychotics is scarce in the current clinical guidelines. In this study, we established pharmacodynamic models to quantify the time–efficacy relationship of three antipsychotic drugs based on the data from a real-world study conducted in China. A total of 373 schizophrenic patients who received antipsychotic monotherapy with olanzapine (n = 144), risperidone (n = 160), or aripiprazole (n = 69) were selected from a three-year prospective, multicenter study. The follow-up times were 13, 26, 52, 78, 104, 130, and 156 weeks after baseline. A time–efficacy model was developed with nonlinear mixed effect method based on changes in Personal and Social Performance (PSP) score compared with the baseline level. Crucial pharmacodynamic parameters, including maximum efficacy and drug onset time, were used to distinguish the efficacy of the three drugs. We quantified the time course of PSP improvement in patients after treatment with these three antipsychotics: olanzapine, risperidone, and aripiprazole reached an E(max) value of 80.3%, 68.2%, and 23.9% at weeks 56.7, 29.2, and 36.8, respectively. General psychotic symptoms, onset frequency, and illness course were identified as significant factors affecting the efficacy of these drugs. The newly constructed models provide an evidence of the benefit of long-term maintenance therapy with atypical antipsychotics in individualized schizophrenia treatment in China. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470854/ doi: 10.1038/s41401-019-0285-x id: cord-317085-qc8bfb9g author: Zhang, Nan title: Risk Factors for Poor Outcomes of Diabetes Patients With COVID-19: A Single-Center, Retrospective Study in Early Outbreak in China date: 2020-09-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Diabetes has been found to increase severity and mortality under the current pandemic of coronavirus disease of 2019 (COVID-19). Up to date, the clinical characteristics of diabetes patients with COVID-19 and the risk factors for poor clinical outcomes are not clearly understood. Methods: The study was retrospectively carried out on enrolled diabetes patients with laboratory confirmed COVID-19 infection from a designated medical center for COVID-19 from January 25th, 2020 to February 14th, 2020 in Wuhan, China. The medical record was collected and reviewed. Univariate and multivariate analyses were performed to assess the risk factors associated with the severe events which were defined as a composite endpoint of admission to intensive care unit, the use of mechanical ventilation, or death. Results: A total of 52 diabetes patients with COVID-19 were finally included in the study. 21 (40.4%) patients had developed severe events in 27.50 (IQR 12.25–35.75) days follow-up, 15 (28.8%) patients experienced life-threatening complications and 8 patients died with a recorded mortality rate of 15.4%. Only 13 patients (41.9%) were in optimal glycemic control with HbA1c value of <7.0%. In addition to general clinical characteristics of COVID-19, the severe events diabetes patients showed higher counts of white blood cells and neutrophil, lower lymphocytes (40, 76.9%), high levels of hs-CRP, erythrocyte sedimentation rate (ESR) and procalcitonin (PCT) as compared to the non-severe diabetes patients. Mild higher level of cardiac troponin I (cTNI) (32.0 pg/ml; IQR 16.80–55.00) and D-dimer (1.70 μg/L, IQR 0.70–2.40) were found in diabetes patients with severe events as compared to the non-severe patients (cTNI:20.00 pg/ml, IQR5.38–30.00, p = 0.019; D-dimer: 0.70 μg/L, IQR 0.30–2.40, p = 0.037). After adjusting age and sex, increased level of cTNI was found to significantly associate with the incidence of severe events (HR: 1.007; 95% CI: 1.000–1.013; p = 0.048), Furthermore, using of α-glucosidase inhibitors was found to be the potential protectant for severe events (HR: 0.227; 95% CI: 0.057–0.904; p = 0.035). Conclusion: Diabetes patients with COVID-19 showed poor clinical outcomes. Vigorous monitoring of cTNI should be recommended for the diabetes patients with COVID-19. Usage of α-glucosidase inhibitors could be a potential protectant for the diabetes patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/33071977/ doi: 10.3389/fendo.2020.571037 id: cord-338756-jzz250o1 author: Zhang, Nan title: Epidemiologic and clinical characteristics of 42 deaths caused by SARS-CoV-2 infection in Wuhan, China: A retrospective study date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This study described the epidemiologic and clinical characteristics of patients who died from SARS-CoV-2 infection, and pointed out the potential risk factors associated with fatal outcomes. Retrospective data from 42 death cases due to SARS-CoV-2 infection at Tongji Hospital Affiliated to Huazhong University of Science and Technology, Wuhan, China was analyzed. Demographics, clinical detection, laboratory findings, and treatments of the deceased were collected and analyzed. The average time between onset of symptoms and admission to the hospitals was 11 ± 5 days of hospitalization. Among the deceased, 60% were with co-morbidities. All of them were having fever and bilateral pneumonia on computed tomography, abnormal infection-related biomarkers, and renal impairment. Abnormal blood coagulation parameters that appeared in more than half of them, were consistent with disseminated intravascular coagulation. All of the patients were treated in the ICU. Based on the fact that SARS-CoV-2 infection carries a risk of mortality, we may infer a few older male patients with underlying comorbidities are likely to have the increased risk. Impaired consciousness level, markers of renal impairment and coagulation abnormalities may be poor prognostic factors. url: https://www.ncbi.nlm.nih.gov/pubmed/32838284/ doi: 10.1016/j.bsheal.2020.07.007 id: cord-291430-rsu6xviv author: Zhang, Qian title: A Mysterious Paratracheal Mass: Parathyroid Carcinoma date: 2020-07-11 words: 1775.0 sentences: 117.0 pages: flesch: 49.0 cache: ./cache/cord-291430-rsu6xviv.txt txt: ./txt/cord-291430-rsu6xviv.txt summary: He was subsequently found to have parathyroid carcinoma as the cause of the acute encephalopathy with impressive serum calcium and parathyroid hormone levels. According to a systemic review conducted from 1995-2003 by Ruda et al., parathyroid carcinoma accounted for 0.74% of cases out of the total study population of 22,225 patients [3] . On days 4-10 of hospitalization, the patient became more lucid as serum calcium level had normalized to 9.1 mg/dL with treatment. The patient remained to have normal serum calcium levels with elevated PTH levels for the next few days. The primary treatment for parathyroid carcinoma is surgical resection, as it offers the greatest chance for potential cure [11] . However, it is advised that the serum calcium levels should be controlled prior to surgery as our patient''s hypercalcemia was normalized after being treated with intravenous fluids, calcitonin, cinacalcet, and pamidronate. Surgical treatment of parathyroid carcinoma (review) abstract: Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. We detail a 60-years-old gentleman who was otherwise healthy presented to the hospital due to acute encephalopathy. He was subsequently found to have parathyroid carcinoma as the cause of the acute encephalopathy with impressive serum calcium and parathyroid hormone levels. The parathyroid carcinoma was later surgically resected with the diagnosis confirmed via pathology specimen. The patient was safely discharged from the hospital with recommendations of close routine outpatient followup. url: https://doi.org/10.7759/cureus.9126 doi: 10.7759/cureus.9126 id: cord-280961-fka8c69p author: Zhang, Rui title: CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city date: 2020-04-11 words: 3651.0 sentences: 211.0 pages: flesch: 50.0 cache: ./cache/cord-280961-fka8c69p.txt txt: ./txt/cord-280961-fka8c69p.txt summary: METHODS: This was a retrospective analysis of the clinical and thoracic CT features of 120 consecutive patients with confirmed SARS-CoV-2 pneumonia admitted to a tertiary university hospital between January 10 and February 10, 2020, in Wuhan city, China. (c) Unenhanced axial CT images of a 27-year-old male doctor with a history of exposure to confirmed SARS-CoV-2 patients, initially presenting with fever (39°C), nonproductive cough, dyspnea, and myalgia (c1) who progressed to a severe case requiring oxygen supplementation (c2). (d) Unenhanced axial CT images of a 52-year-old male doctor with asthma and exposure to confirmed SARS-CoV-2 patients, initially presenting with fever (39°C), non-productive cough, dyspnea, and myalgia who rapidly progressed to a severe form requiring mechanical ventilation. In this study, we reported the clinical characteristics and chest CT findings at presentation for all types of SARS-CoV-2 pneumonia severity. abstract: OBJECTIVES: To characterize the chest computed tomography (CT) findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) according to clinical severity. We compared the CT features of common cases and severe cases, symptomatic patients and asymptomatic patients, and febrile and afebrile patients. METHODS: This was a retrospective analysis of the clinical and thoracic CT features of 120 consecutive patients with confirmed SARS-CoV-2 pneumonia admitted to a tertiary university hospital between January 10 and February 10, 2020, in Wuhan city, China. RESULTS: On admission, the patients generally complained of fever, cough, shortness of breath, and myalgia or fatigue, with diarrhea often present in severe cases. Severe patients were 20 years older on average and had comorbidities and an elevated lactate dehydrogenase (LDH) level. There were no differences in the CT findings between asymptomatic and symptomatic common type patients or between afebrile and febrile patients, defined according to Chinese National Health Commission guidelines. CONCLUSIONS: The clinical and CT features at admission may enable clinicians to promptly evaluate the prognosis of patients with SARS-CoV-2 pneumonia. Clinicians should be aware that clinically silent cases may present with CT features similar to those of symptomatic common patients. KEY POINTS: • The clinical features and predominant patterns of abnormalities on CT for asymptomatic, typic common, and severe cases were summarized. These findings may help clinicians to identify severe patients quickly at admission. • Clinicians should be cautious that CT findings of afebrile/asymptomatic patients are not better than the findings of other types of patients. These patients should also be quarantined. • The use of chest CT as the main screening method in epidemic areas is recommended. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00330-020-06854-1) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s00330-020-06854-1 doi: 10.1007/s00330-020-06854-1 id: cord-322054-whjisspt author: Zhang, S. title: Concerns about disease management and psychological stress in SAPHO patients during the COVID-19 epidemic date: 2020-05-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objectives The coronavirus disease 2019 (COVID-19) epidemic brings potentially impact on the care of patients with rheumatic diseases, including SAPHO syndrome. We aimed to investigate the disease status, concerns about management, and psychological stress in SAPHO patients during the COVID-19 epidemic. Method A structured questionnaire was distributed online to patients with SAPHO syndrome enrolled in a Chinese cohort study on March 3rd, 2020. Patients were ask about the current treatments, disease status, and concerns about disease management during the epidemic. Psychologic stress (scored from 0 to 10 points) and psychological problems were reported by the patients. Results A total of 157 patients (mean age 38.4 {+/-} 12.3 years, 66.9% females) were included in the study. None of the patients were diagnosed with COVID-19. Sixty-five (41.4%) patients worried about their disease conditions during the epidemic with concerns including medication shortage (73.8%), delay of consultation (46.2%), and disease aggravation (61.5%). Sixty-seven (42.7%) patients had medication withdrawal or dose reduction due to lack of drugs, irregular daily schedule or subjective reasons. The most common psychological problems reported was little interest or pleasure in doing things (66.2%). Patients with progressive disease condition were more distressed and disturbed by the epidemic. Patients with nail involvement felt more worried about their disease conditions than patients without (59.6% vs 31.0%, p =0. 001). Conclusions The COVID-19 epidemic imposes a negative impact on the disease management and psychological stress in SAPHO patients. Patients' access to specialty care and medication well as mental stress is of great concern. url: http://medrxiv.org/cgi/content/short/2020.05.07.20084087v1?rss=1 doi: 10.1101/2020.05.07.20084087 id: cord-283583-pwlbrxn3 author: Zhang, Xiao-Ai title: Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012 date: 2015-01-09 words: 3779.0 sentences: 207.0 pages: flesch: 51.0 cache: ./cache/cord-283583-pwlbrxn3.txt txt: ./txt/cord-283583-pwlbrxn3.txt summary: A higher frequency of severe clinical outcome and nervous system manifestation were also observed in the SAFV-positive HFMD patients. A patient was considered to be infected with SAFV when positive detection was obtained in any type of the samples. Genetic characterization of SAFVs. A phylogenetic tree was constructed based on the VP1 nucleotide sequences of Saffold cardiovirus detected in clinical samples of 82 patients in the current study, and sequences downloaded from GenBank by maximum likelihood method using MEGA 6.0 (Figure 1) . Detection of SAFV in sera and CSFs. Additional 171 CSFs were collected from patients with HFMD-associated encephalitis, and six (3.5%) were found to be SAFV-positive using real-time RT-PCR, and five were further confirmed by nested RT-PCR targeting the 59-UTR. In our study, SAFVs were co-detected with other viruses in 14 (82.4%), 9 (75.0%), and 28 (32.6) specimens in ARTI, diarrhea and HFMD patients respectively. abstract: The epidemiology and clinical features of the Saffold cardiovirus (SAFV) remain ambiguous. The present study was designed to systematically and intensively investigate the epidemiological features of SAFV in pediatric patients in China. Three cohorts of pediatric patients were recruited from 2009 to 2012. Cohort 1 comprised patients with acute respiratory tract infections. Cohort 2 comprised patients with diarrhea. Cohort 3 comprised hand, foot, and mouth disease (HFMD) patients. A total of 115 patients (1.6%) among 6052 (17/1647, 12/2013, and 86/2392 in cohorts 1, 2, and 3, respectively) were SAFV-positive. The samples from 82 SAFV-positive patients were successfully sequenced, and four genotypes were identified: 8 SAFV-1, 41 SAFV-2, 29 SAFV-3, and 4 SAFV-6. A significantly higher detection rate was found in the HFMD patients than in other two cohorts (both P <0.001). A higher frequency of severe clinical outcome and nervous system manifestation were also observed in the SAFV-positive HFMD patients. Additionally, 6 (3.5%) cerebrospinal fluid and 7 (2.2%) serum samples from the HFMD-associated encephalitis patients were SAFV-positive. Based on the VP1 sequences, all four genotypes displayed distinct geographical clustering. SAFV infection might be associated with a wide clinical spectrum and contribute to HFMD. url: https://www.ncbi.nlm.nih.gov/pubmed/25572936/ doi: 10.1038/srep07704 id: cord-300445-qzu4gz2d author: Zhang, Xiao-lei title: Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives date: 2020-09-23 words: 7247.0 sentences: 376.0 pages: flesch: 37.0 cache: ./cache/cord-300445-qzu4gz2d.txt txt: ./txt/cord-300445-qzu4gz2d.txt summary: Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. However, chloroquine phosphate and its derivative hydroxychloroquine, which have been used for decades in the treatment and prevention of malaria and chronic inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, were discovered to have a high inhibitory potency against SARS-CoV-2 infection in vitro [2] [3] [4] [5] and favorable clinical and virologic benefits in COVID-19 patients [6] [7] [8] [9] [10] , and they have emerged as important therapies for COVID-19 in several countries, including China, France, USA, and India, although the mechanisms of their anti-COVID-19 effects remain unclear. abstract: The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. Therefore, chloroquine phosphate was first used in the treatment of COVID-19 in China. Later, under a limited emergency-use authorization from the FDA, hydroxychloroquine in combination with azithromycin was used to treat COVID-19 patients in the USA, although the mechanisms of the anti-COVID-19 effects remain unclear. Preliminary outcomes from clinical trials in several countries have generated controversial results. The desperation to control the pandemic overrode the concerns regarding the serious adverse effects of chloroquine derivatives and combination drugs, including lethal arrhythmias and cardiomyopathy. The risks of these treatments have become more complex as a result of findings that COVID-19 is actually a multisystem disease. While respiratory symptoms are the major clinical manifestations, cardiovascular abnormalities, including arrhythmias, myocarditis, heart failure, and ischemic stroke, have been reported in a significant number of COVID-19 patients. Patients with preexisting cardiovascular conditions (hypertension, arrhythmias, etc.) are at increased risk of severe COVID-19 and death. From pharmacological and cardiovascular perspectives, therefore, the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated, and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events. url: https://doi.org/10.1038/s41401-020-00519-x doi: 10.1038/s41401-020-00519-x id: cord-306670-c2jm0g88 author: Zhang, Yan title: Association of Diabetes Mellitus with Disease Severity and Prognosis in COVID-19: A Retrospective Cohort Study date: 2020-05-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The 2019 novel coronavirus disease (COVID-19) emerged in Wuhan, China, and was characterized as a pandemic by the World Health Organization. Diabetes is an established risk associated with poor clinical outcomes, but the association of diabetes with COVID-19 has not been reported yet. Methods In this cohort study, we retrospectively reviewed 258 consecutive hospitalized COVID-19 patients with or without diabetes at the West Court of Union Hospital in Wuhan, China, recruited from January 29 to February 12, 2020. The clinical features, treatment strategies and prognosis data were collected and analyzed. Prognosis was followed up until March 12, 2020. Results Of the 258 hospitalized patients (63 with diabetes) with COVID-19, the median age was 64 years (range 23-91), and 138 (53.5%) were male. Common symptoms included fever (82.2%), dry cough (67.1%), polypnea (48.1%), and fatigue (38%). Patients with diabetes had significantly higher leucocyte and neutrophil counts, and higher levels of fasting blood glucose, serum creatinine, urea nitrogen and creatine kinase isoenzyme MB at admission compared with those without diabetes. COVID-19 patients with diabetes were more likely to develop severe or critical disease conditions with more complications, and had higher incidence rates of antibiotic therapy, non-invasive and invasive mechanical ventilation, and death (11.1% vs. 4.1%). Cox proportional hazard model showed that diabetes (adjusted hazard ratio [aHR]=3.64; 95% confidence interval [CI]: 1.09, 12.21) and fasting blood glucose (aHR=1.19; 95% CI: 1.08, 1.31) were associated with the fatality due to COVID-19, adjusting for potential confounders. Conclusions Diabetes mellitus is associated with increased disease severity and a higher risk of mortality in patients with COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32446795/ doi: 10.1016/j.diabres.2020.108227 id: cord-332861-7b5pzmk6 author: Zhang, Zhan title: Clinical Features and Treatment of 2019-nCov Pneumonia Patients in Wuhan: Report of A Couple Cases date: 2020-02-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s12250-020-00203-8 doi: 10.1007/s12250-020-00203-8 id: cord-254428-n0uwy77g author: Zhao, Wen title: Clinical characteristics and durations of hospitalized patients with COVID-19 in Beijing: a retrospective cohort study date: 2020-03-17 words: 3390.0 sentences: 202.0 pages: flesch: 53.0 cache: ./cache/cord-254428-n0uwy77g.txt txt: ./txt/cord-254428-n0uwy77g.txt summary: Multivariable stepwise Cox regression model showed bilateral pneumonia on CT scan, shorter time from the illness onset to admission, the severity of disease and lymphopenia were independently associated with longer hospitalized duration. In the present study, we reported the retrospective data of 77 hospitalized patient with COVID-19 in Beijing, China, with 64 (83.1%) discharged home alive by the end of follow-up. Previous studies reported that the duration of the illness onset to hospital admission in the early stage of this outbreak was 7 to 12.5 days. Currently, few studies reported the average hospital length of stay of discharged patients COVID-19. Bilateral pneumonia on CT scan, shorter period of illness onset to admission, lymphopenia, severity of disease are the risk factors for longer hospitalization duration of COVID-19. Bilateral pneumonia on CT scan, shorter period of illness onset to admission, lymphopenia, severity of disease are the risk factors for longer hospitalization duration of COVID-19. abstract: Background: COVID-19 is still becoming an increasing global threat to public health. More detailed and specific characteristics of COVID-19 are needed to better understand this disease. Additionally, durations of COVID-19, e.g., the average time from exposure to recovery, which is of great value in understanding this disease, has not been reported so far. Aims: To give the information on clinical characteristics and different durations of COVID-19 and to identify the potential risk factors for longer hospitalization duration. Methods: In this retrospective study, we enrolled 77 patients (mean age: 52 years; 44.2% males) with laboratory-confirmed COVID-19 admitted to Beijing YouAn Hospital during 21st Jan and 8th February 2020. Epidemiological, clinical and radiological data on admission were collected; complications and outcomes were followed up until 29th February 2020. The study endpoint was the discharge within two weeks. Cox proportional-hazards regression was performed to identify risk factors for longer hospitalization duration. Results: Of 77 patients, there are 34 (44.2%) males, 24 (31.2%) with comorbidities, 22 (28.6%) lymphopenia, 20 (26.0%) categorized as severe patients, and 28 (36.4%) occurred complications. By the end of follow-up, 64 (83.1%) patients were discharged home after being tested negative for SARS-CoV-2 infections, 8 remained in hospital and 5 died. 36 (46.8%) patients were discharged within 14 days and thus reached the study endpoint, including 34 (59.6%) of 57 non-severe patients and 2 (10%) of 20 severe patients. The overall cumulative probability of the endpoint was 48.3%. Hospital length of stay and duration of exposure to discharge for 64 discharged patients were 13 (10-16.5) and 23 (18-24.5) days, respectively. Multivariable stepwise Cox regression model showed bilateral pneumonia on CT scan, shorter time from the illness onset to admission, the severity of disease and lymphopenia were independently associated with longer hospitalized duration. Conclusions: COVID-19 has significantly shorter duration of disease and hospital length of stay than SARS. Bilateral pneumonia on CT scan, shorter period of illness onset to admission, lymphopenia, the severity of disease are the risk factors for longer hospitalization duration of COVID-19. url: https://doi.org/10.1101/2020.03.13.20035436 doi: 10.1101/2020.03.13.20035436 id: cord-328040-5qd05e4r author: Zhao, Xin-Ying title: Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study date: 2020-04-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Since December 2019, the 2019 coronavirus disease (COVID-19) has expanded to cause a worldwide outbreak that more than 600,000 people infected and tens of thousands died. To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described. METHODS: We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. RESULTS: Of the 91 patients diagnosed with COVID-19, 30 cases (33.0%) were severe and two patients (2.2%) died. The severe disease group tended to be older (50.5 vs. 42.0 years; p = 0.049) and have more chronic disease (40% vs. 14.8%; p = 0.009) relative to mild disease group. Only 73.6% of the patients were quantitative polymerase chain reaction (qPCR)-positive on their first tests, while typical chest computed tomography images were obtained for each patient. The most common complaints were cough (n = 75; 82.4%), fever (n = 59; 64.8%), fatigue (n = 35; 38.5%), and diarrhea (n = 14; 15.4%). Non-respiratory injury was identified by elevated levels of aspartate aminotransferase (n = 18; 19.8%), creatinine (n = 5; 5.5%), and creatine kinase (n = 14; 15.4%) in laboratory tests. Twenty-eight cases (30.8%) suffered non-respiratory injury, including 50% of the critically ill patients and 21.3% of the mild patients. CONCLUSIONS: Overall, the mortality rate of patients in Jingzhou was lower than that of Wuhan. Importantly, we found liver, kidney, digestive tract, and heart injuries in COVID-19 cases besides respiratory problems. Combining chest computed tomography images with the qPCR analysis of throat swab samples can improve the accuracy of COVID-19 diagnosis. url: https://www.ncbi.nlm.nih.gov/pubmed/32345226/ doi: 10.1186/s12879-020-05010-w id: cord-016559-tqd7m2i1 author: Zheng, Yi title: Application in Medicine Systems date: 2014-10-28 words: 19346.0 sentences: 778.0 pages: flesch: 48.0 cache: ./cache/cord-016559-tqd7m2i1.txt txt: ./txt/cord-016559-tqd7m2i1.txt summary: Danshen has the function of effectively dilating the coronary artery, increasing coronary blood flow, reducing heart rate, inhibiting platelet aggregation and thrombopoiesis induced by platelet activation factors, promoting the recovery of injured cardiac muscle, increasing cardiac contractility, and protecting cardiac muscle cells; thus it can be widely applied in treating the diseases of the circulation system. [7] reported the application of 0.5/ 250 ml of puerarin and glucose injection combined with 16 ml of CDI in the treatment of 44 patients with coronary heart disease and angina pectoris, and the results showed that in the treatment group there were 31 patients with a marked effect, 10 patients with an effect, 3 patients without effect, and the total effective rate was 93.2 %. Patients with cerebral hemorrhage were treated with CDI, and the rates of recovery and significant improvement in the treatment group were significantly better than those in the control group, and no side effects were observed. abstract: Modern pharmacological studies on Danshen have shown that the pharmacologic actions of Danshen mainly include dilating vessels, promoting blood flow, improving microcirculation, changing blood viscosity, increasing myocardial blood and oxygen supplies, reducing myocardial consumption of oxygen, etc. The drug is used to treat diseases of the cardio-cerebrovascular system. In addition, Danshen also has antitumor, antibacterial, and anti-inflammatory functions. Therefore, Danshen has wide clinical application. In recent years, there has been an increase in the number of reports on the clinical application of Danshen extract and Danshen compound preparations. Danshen is seldom used alone; rather, it is usually combined with other drugs to form compound preparations. Various Danshen preparations have been developed, such as Compound Danshen Tablets, Compound Danshen Dropping Pill ( Dantonic™), Compound Danshen Granules, Compound Danshen Capsule, Compound Danshen Oral Liquid, Compound Danshen Aerosol, and Compound Danshen Injection (CDI), etc. The successful development of these preparations has improved product quality, enhanced efficacy, and opened up broader prospects for Danshen’s clinical application. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120891/ doi: 10.1007/978-94-017-9466-4_1 id: cord-288810-ab7k70c4 author: Zheng, Yingyan title: Development and Validation of a Prognostic Nomogram Based on Clinical and CT Features for Adverse Outcome Prediction in Patients with COVID-19 date: 2020-06-24 words: 3369.0 sentences: 188.0 pages: flesch: 42.0 cache: ./cache/cord-288810-ab7k70c4.txt txt: ./txt/cord-288810-ab7k70c4.txt summary: title: Development and Validation of a Prognostic Nomogram Based on Clinical and CT Features for Adverse Outcome Prediction in Patients with COVID-19 OBJECTIVE: The purpose of our study was to investigate the predictive abilities of clinical and computed tomography (CT) features for outcome prediction in patients with coronavirus disease (COVID-19). The prognostic nomogram based on the combination of clinical and CT features could be a useful tool for predicting adverse outcomes of patients with COVID-19. Chest CT manifestations of regional involvement, scattering distribution, transverse distribution, the number of involved https://doi.org/10.3348/kjr.2020.0485 kjronline.org pulmonary segments, extent, shape, ground-glass opacity (GGO), consolidation, crazy-paving sign, halo sign, reversed halo sign (RHS), air bronchogram, bronchiectasis, vascular enlargement, pleural thickening, pleural retraction, pleural effusion, and mediastinal lymphadenopathy were assessed. The nomogram developed using a combination of clinical and CT features could aid in https://doi.org/10.3348/kjr.2020.0485 kjronline.org predicting adverse outcomes for patients with COVID-19. abstract: OBJECTIVE: The purpose of our study was to investigate the predictive abilities of clinical and computed tomography (CT) features for outcome prediction in patients with coronavirus disease (COVID-19). MATERIALS AND METHODS: The clinical and CT data of 238 patients with laboratory-confirmed COVID-19 in our two hospitals were retrospectively analyzed. One hundred sixty-six patients (103 males; age 43.8 ± 12.3 years) were allocated in the training cohort and 72 patients (38 males; age 45.1 ± 15.8 years) from another independent hospital were assigned in the validation cohort. The primary composite endpoint was admission to an intensive care unit, use of mechanical ventilation, or death. Univariate and multivariate Cox proportional hazard analyses were performed to identify independent predictors. A nomogram was constructed based on the combination of clinical and CT features, and its prognostic performance was externally tested in the validation group. The predictive value of the combined model was compared with models built on the clinical and radiological attributes alone. RESULTS: Overall, 35 infected patients (21.1%) in the training cohort and 10 patients (13.9%) in the validation cohort experienced adverse outcomes. Underlying comorbidity (hazard ratio [HR], 3.35; 95% confidence interval [CI], 1.67–6.71; p < 0.001), lymphocyte count (HR, 0.12; 95% CI, 0.04–0.38; p < 0.001) and crazy-paving sign (HR, 2.15; 95% CI, 1.03–4.48; p = 0.042) were the independent factors. The nomogram displayed a concordance index (C-index) of 0.82 (95% CI, 0.76–0.88), and its prognostic value was confirmed in the validation cohort with a C-index of 0.89 (95% CI, 0.82–0.96). The combined model provided the best performance over the clinical or radiological model (p < 0.050). CONCLUSION: Underlying comorbidity, lymphocyte count and crazy-paving sign were independent predictors of adverse outcomes. The prognostic nomogram based on the combination of clinical and CT features could be a useful tool for predicting adverse outcomes of patients with COVID-19. url: https://doi.org/10.3348/kjr.2020.0485 doi: 10.3348/kjr.2020.0485 id: cord-017715-99ri6x0y author: Zhou, Bo-Ping title: SARS date: 2015-07-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Severe acute respiratory syndrome (SARS) is an acute respiratory tract infectious disease induced by SARS-CoV and mainly transmitted through the short-distance air droplets and close contact. Its main clinical characteristics is abrupt onset of the disease and the initial symptom is fever accompanied with systematic symptoms of headache, soreness and fatigue, and respiratory tract symptoms such as cough, chest dullness, and dyspnea. A few cases may progress to acute respiratory distress syndrome (ARDS). Due to its self-limiting feature, the prognosis is predominantly good but may be poor in severe cases, with mortality about 9.3 %. Some patients may develop such complications such as lung fibrosis and necrosis of the head of femur. On April 8, 2003, SARS was defined as a legal infectious disease by the Ministry of Heath of China. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122356/ doi: 10.1007/978-94-017-7363-8_2 id: cord-277207-2my86ums author: Zhou, H. title: Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19) date: 2020-04-15 words: 3609.0 sentences: 234.0 pages: flesch: 47.0 cache: ./cache/cord-277207-2my86ums.txt txt: ./txt/cord-277207-2my86ums.txt summary: We also presented bone marrow aspiration pathology of three patients with delayed phase thrombocytopenia, showing impaired maturation of megakaryocytes. There were two inclusion criteria for this study: (1) each patient was confirmed by real-time reverse transcription PCR (real-time RT-PCR) and were diagnosed as having COVID-19 according to WHO interim guidance [6] ; (2) all patients underwent chest computerized tomography (CT) and complete panel of routine laboratory tests, including compete blood count, blood biochemistry, blood coagulation function, test of key inflammatory cytokines (IL-4, IL-6, IL-10, IFN-γ, TNF-α), and lymphocytes subset analysis. We collected data on age, gender, respiratory rate, smoking and comorbidities (Hepatitis B, Hepatitis C, HIV, hepatosplenomegaly, hematological system disease, rheumatic immune system disease, cardio cerebrovascular disease, endocrine system disease, respiratory system disease, digestive system disease, nervous system disease and malignant tumor), symptoms from onset to hospital admission (fever, cough, dyspnea, pharyngalgia, diarrhea, anorexia, abdominal pain, palpitation, hypodynamia, paresthesia, myalgia and dizziness), laboratory values on admission (blood routine, blood coagulation function, blood biochemistry, C-reactive protein, inflammatory cytokines and lymphocyte Subsets ), treatment (antiviral agents, antibacterial agents, antifungal agents, corticosteroids, inhaled interferon-α, All rights reserved. abstract: The pandemic COVID19 pneumonia has engulfed the entire world. Hematopoietic system can also be affected by COVID19. Thrombocytopenia at admission was prevalent, while late phase or delayed phase thrombocytopenia is obscure. This retrospective case series analyzed patients with COVID19 at the Union Hospital, Wuhan, China, from January 25th to March 9th, 2020. Analysis began on March 11th, 2020. COVID19 associated delayed phase thrombocytopenia was occurred in 11.8% percent of enrolled patients. The delayed phase thrombocytopenia in COVID19 is prone to develop in elderly patients or patients with low lymphocyte count on admission. The delayed-phase thrombocytopenia is significantly associated with increased length of hospital stay and higher ICU admission rate. Delayed phase nadir platelet counts demonstrated a high and significantly negative linear correlation with B cell percentages and serum IL 6 levels. We also presented bone marrow aspiration pathology of three patients with delayed phase thrombocytopenia, showing impaired maturation of megakaryocytes. We speculated that the delayed phase platelet destruction might be mediated by antibodies, and suggest immunoregulatory treatment in severe patients to improve outcomes. Besides, clinicians need to pay attention to the delayed phase thrombocytopenia especially at 3 to 4 weeks after symptom onset. url: https://doi.org/10.1101/2020.04.11.20059170 doi: 10.1101/2020.04.11.20059170 id: cord-320349-6hbuq0k7 author: Zhou, Hua title: Development of early warning and rapid response system for patients with novel coronavirus pneumonia (COVID-19): A research protocol date: 2020-08-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) has caused serious damage to public health. COVID-19 has no vaccine or specific therapy; its mortality rate increases significantly once patients deteriorate. Furthermore, intensive monitoring of COVID-19 is limited by insufficient medical resources and increased risks of exposure to medical staff. We therefore aim to build an early warning and rapid response system (EWRRS) to address these problems. METHOD: The research is designed as a prospective cohort study, to verify a dynamic and interactive evaluation system; it includes patient self-reporting, active monitoring, early alarming and treatment recommendations. Adult patients diagnosed with COVID-19 will be recruited from Sept 2020 to Aug 2021 at a tertiary contagious hospital. Patients with life expectancy <48 hours, pregnant or lactating, in immunosuppression states or end-stage diseases will be excluded. The intervention is implementation of EWRRS to detect early signs of clinical deterioration of COVID-19 patients, to provide timely and efficient treatment suggestions by the system. EWRRS can determine the classification and interactive evaluation of patient information; the determination is based on the application of 3 different scenario modules, separately driven by patients, nurses, and physicians. The primary outcome is change in disease severity category after treatment. Secondary outcomes include the proportion of patients with different disease severity types; critical deterioration events; patients who had unplanned transfers to an intensive care unit (ICU) and required critical care interventions; intervals from warning to implementation of clinical interventions; hospital mortality; length of ICU and hospital stay; workload of medical staff and risks of exposure to COVID-19. DISCUSSION: Our hypothesis is that EWRRS provides an example of an early identification, warning, and response system for COVID-19. In addition, EWRRS can potentially be extended to use as a grading metric for general critically ill patients in an ICU setting. url: https://www.ncbi.nlm.nih.gov/pubmed/32846843/ doi: 10.1097/md.0000000000021874 id: cord-287222-wojyisu0 author: Zhou, Min title: Coronavirus disease 2019 (COVID-19): a clinical update date: 2020-04-02 words: 5683.0 sentences: 276.0 pages: flesch: 35.0 cache: ./cache/cord-287222-wojyisu0.txt txt: ./txt/cord-287222-wojyisu0.txt summary: Of the first 99 laboratory-confirmed patients, 49 (49%) had been exposed to HSWM, which was reported to be the possible initial source of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) [5] . New Coronavirus Infection Diagnosis and Treatment Scheme (Trial Version) published by Military Support Hubei Medical Team also put forward that for mild to moderate COVID-19 patients, corticosteroids should not be given principally and highdose corticosteroid pulse therapy was not recommended. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19) abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials. url: https://www.ncbi.nlm.nih.gov/pubmed/32240462/ doi: 10.1007/s11684-020-0767-8 id: cord-295123-x2gxgave author: Zhou, Wei title: Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia date: 2020-02-21 words: 1705.0 sentences: 77.0 pages: flesch: 36.0 cache: ./cache/cord-295123-x2gxgave.txt txt: ./txt/cord-295123-x2gxgave.txt summary: However, according to the Chinese government''s daily report, 13.2-21.3% of patients with 2019-nCoV infection developed into severe or fatal illness (Fig. S1a ), which is characterized by the rapid development to acute respiratory distress syndrome (ARDS) or septic shock. On February 7, 2020, the China''s National Health Commission released the fifth trial version of Diagnosis and Treatment Scheme for Pneumonitis with 2019-nCoV Infection, and provided a systematic treatment strategy for severe cases. Some scholars may not support the corticosteroids treatment for novel coronavirus pneumonia (NCP), because observational studies and systematic reviews have indicated inconclusive clinical evidence on the effect of corticosteroids therapy for viral pneumonias (such as SARS, MERS and H1N1). Evidently, all these results strongly suggest that proper use of low-dose corticosteroids may bring survival advantages for critically ill patients with 2019-nCoV, but this treatment should be strictly performed on NCP patients with definite clinical indications (such as refractory ARDS, sepsis or septic shock) according to the recommended guidelines. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32133159/ doi: 10.1038/s41392-020-0127-9 id: cord-263716-ywsm11aw author: Zhou, Yifan title: Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management date: 2020-05-04 words: 1795.0 sentences: 145.0 pages: flesch: 60.0 cache: ./cache/cord-263716-ywsm11aw.txt txt: ./txt/cord-263716-ywsm11aw.txt summary: Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. At the later clinical symptomatic phase, the immune system is fully activated and the disease may enter the severe infection stage in this phase. Although many patients are known for their respiratory symptoms, they had neurological symptoms in their first 1–2 days of clinical symptomatic phase, and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase. 3 However, we have found that many patients had neurological symptoms in their early stages, 4 and ischaemic stroke often happened around 2 weeks after the onset of infection. 9 Patients with COVID-19 often have insidious clinical symptoms, without fever or coughing, even though their lungs may have rather severe damages. His nucleic acid testing of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was positive. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China abstract: Coronavirus disease-2019 (COVID‐19) has become a global pandemic. COVID-19 runs its course in two phases, the initial incubation phase and later clinical symptomatic phase. Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. At the later clinical symptomatic phase, the immune system is fully activated and the disease may enter the severe infection stage in this phase. Although many patients are known for their respiratory symptoms, they had neurological symptoms in their first 1–2 days of clinical symptomatic phase, and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase. The key is to prevent a patient from progressing to this severe infection from mild infection. We are sharing our experience on prevention and management of COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32366614/ doi: 10.1136/svn-2020-000398 id: cord-336306-hvy9ukhh author: Zhu, Jieyun title: Clinical characteristics of 3,062 COVID‐19 patients: a meta‐analysis date: 2020-04-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: We aim to systematically review the clinical characteristics of Coronavirus disease 2019 (COVID‐19). METHODS: Seven datebases were searched to collect studies about the clinical characteristics of COVID‐19 from 1 January 2020 to 28 February 2020. Then, meta‐analysis was performed by using Stata12.0 software. RESULTS: A total of 38 studies involving 3 062 COVID‐19 patients were included. Meta‐analysis showed that a higher proportion of infected patients were male (56.9%). The incidence rate of respiratory failure or ARDS was 19.5% and the fatality rate was 5.5%. Fever (80.4%), fatigue (46%), cough (63.1%) and expectoration (41.8%) were the most common clinical manifestations. Other common symptoms included muscle soreness (33%), anorexia (38.8%), chest tightness (35.7%), shortness of breath (35%), dyspnea (33.9%). Minor symptoms included nausea and vomiting (10.2%), diarrhea (12.9%), headache (15.4%), pharyngalgia(13.1%), shivering (10.9%) and abdominal pain (4.4%). Patients with asymptomatic was 11.9%. Normal leukocytes counts (69.7%), lymphopenia (56.5%), elevated C‐reactive protein levels (73.6%), elevated ESR (65.6%) and oxygenation index decreased (63.6%) were observed in most patients. About 37.2% of patients with elevated D‐dimer, 25.9% of patients with leukopenia, along with abnormal levels of liver function (29%) and renal function (25.5%). Other findings included leukocytosis (12.6%) and elevated procalcitonin (17.5%). Only 25.8% of patients had lesions involving single lung and 75.7% of patients had lesions involving bilateral lungs. CONCLUSIONS: The most commonly experienced symptoms of COVID‐19 patients were fever, fatigue, cough and expectoration. A relatively small percentage of patients were asymptomatic. Most patients showed normal leucocytes counts, lymphopenia, elevated levels of C‐reactive protein and ESR. Bilateral lungs involvement was common. This article is protected by copyright. All rights reserved. url: https://doi.org/10.1002/jmv.25884 doi: 10.1002/jmv.25884 id: cord-312192-hxhohtmj author: Zhu, Lan title: Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China date: 2020-04-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Previous studies on coronavirus disease 2019 (COVID-19) have focused on populations with normal immunity, but lack data on immunocompromised populations. OBJECTIVE: To evaluate the clinical features and outcomes of COVID-19 pneumonia in kidney transplant recipients. DESIGN, SETTING, AND PARTICIPANTS: A total of 10 renal transplant recipients with laboratory-confirmed COVID-19 pneumonia were enrolled in this retrospective study. In addition, 10 of their family members diagnosed with COVID-19 pneumonia were included in the control group. INTERVENTION: Immunosuppressant reduction and low-dose methylprednisolone therapy. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The clinical outcomes (the severity of pneumonia, recovery rate, time of virus shedding, and length of illness) were compared with the control group by statistical analysis. RESULTS AND LIMITATIONS: The clinical symptomatic, laboratory, and radiological characteristics of COVID-19 pneumonia in the renal transplant recipients were similar to those of severe COVID-19 pneumonia in the general population. The severity of COVID-19 pneumonia was greater in the transplant recipients than in the control group (five severe/three critical cases vs one severe case). Five patients developed transient renal allograft damage. After a longer time of virus shedding (28.4 ± 9.3 vs 12.2 ± 4.6 d in the control group) and a longer course of illness (35.3 ± 8.3 vs 18.8 ± 10.5 d in the control group), nine of the 10 transplant patients recovered successfully after treatment. One patient developed acute renal graft failure and died of progressive respiratory failure. CONCLUSIONS: Kidney transplant recipients had more severe COVID-19 pneumonia than the general population, but most of them recovered after a prolonged clinical course and virus shedding. Findings from this small group of cases may have important implications for the treatment of COVID-19 pneumonia in immunosuppressed populations. PATIENT SUMMARY: Immunosuppressed transplant recipients with coronavirus disease 2019 infection had more severe pneumonia, but most of them still achieved a good prognosis after appropriate treatment. url: https://doi.org/10.1016/j.eururo.2020.03.039 doi: 10.1016/j.eururo.2020.03.039 id: cord-261062-9zhe3ejy author: Zhu, Shu-Ting title: Utility of Point-of-Care Lung Ultrasound for Clinical Classification of COVID-19 date: 2020-09-21 words: 2743.0 sentences: 149.0 pages: flesch: 51.0 cache: ./cache/cord-261062-9zhe3ejy.txt txt: ./txt/cord-261062-9zhe3ejy.txt summary: In this study, the utility of point-of-care lung ultrasound for the clinical classification of coronavirus disease (COVID-19) was prospectively assessed. Twenty-seven adult patients with COVID-19 underwent bedside lung ultrasonography (LUS) examinations three times within the first two weeks of admission to the isolation ward. Early studies suggested that the irregular pleural line with small subpleural consolidations, white lung, confluents and irregular vertical artifacts (B-lines) are ultrasonic manifestations of COVID-19 pneumonia , and LUS scores have been used for the identification of patients with lung involvement and disease severity (Vetrugno et al. According to Spearman correlation test results (Table 2) Then, we divided the LUS scores into three scales (low ≤9; 95 log(10) copies/mL and ALT more than two times the upper normal limit. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712310/ doi: 10.1007/s12072-009-9123-4 id: cord-000718-7whai7nr author: nan title: ESP Abstracts 2012 date: 2012-08-22 words: 166497.0 sentences: 12847.0 pages: flesch: 49.0 cache: ./cache/cord-000718-7whai7nr.txt txt: ./txt/cord-000718-7whai7nr.txt summary: Method: We analyzed consecutive gastric cancer cases in terms of AMACR immunohistochemical expression and clinical/pathological characteristics and followed patients'' postoperative history. Results: Histological, immunohistochemical and molecular examination revealed non-neoplastic lymphadenopathy with atypical paracortical T-cell hyperplasia with immunoblastic reaction in the former and burnt-out histiocytic pattern in the latter, both falling into a broad spectrum of reactive lymph node changes associated with Still''s disease. Method: We have thus collected, from our two Institutions a large number (45 cases) of cancers showing the histological definition of adenosquamous carcinomas according to the WHO criteria and performed gene analysis for k-RAS (codons 12, 13) and EGFR (codons 18, 19 and 21) mutations. Objective: We previously identified amplified fibroblast growth factor 1 (FGFR1) as a therapeutic target for small molecule inhibitor (SMI) therapy in squamous cell lung cancer (L-SCC), resulting in currently running clinical trials treating patients with stage III disease. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400751/ doi: 10.1007/s00428-012-1284-1 id: cord-000843-e1bn79ui author: nan title: ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme date: 2011-03-01 words: 91224.0 sentences: 4805.0 pages: flesch: 41.0 cache: ./cache/cord-000843-e1bn79ui.txt txt: ./txt/cord-000843-e1bn79ui.txt summary: The role of radiology includes (a) characterisation of sonographically indeterminate adnexal masses, (b) staging as guidance for surgery and treatment planning (including identification of sites of non optimal resectabilty) in suspected ovarian cancer, (c) assessment of recurrent disease, and (d) in selected cases image-guided biopsy. The association of multiple markers of structural and functional imaging (MRI and PET) and the use of advanced computational analysis techniques will allow better management of AD but it needs a broader validation and know the most efficient combination of biomarkers at each stage of the disease, including the preclinical period. Although the basic techniques for DCE-CT have been available for decades, more recently a range of technological advances have contributed to the greater applicability of perfusion CT in the clinical environment including wider CT detectors, shorter gantry rotation times, ''table-toggling'', radiation dose reduction and software corrections for image mis-registration due to respiratory or other patient motion. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533621/ doi: 10.1007/s13244-011-0078-3 id: cord-000977-ka4261wc author: nan title: ECR 2013 Book of Abstracts - B - Scientific Sessions date: 2013-03-07 words: 132895.0 sentences: 8080.0 pages: flesch: 50.0 cache: ./cache/cord-000977-ka4261wc.txt txt: ./txt/cord-000977-ka4261wc.txt summary: Methods and Materials: Mean attenuation, contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) at abdominal aorta, right renal artery (RRA) and left renal artery (LRA) were measured in 24 kidney donors who had undergone CTA with tube current modulation, 120 kVp, filtered back projection reconstruction algorithm (Group A) and were compared with 24 BMI-matched kidney donors who had undergone CTA with automated kVp selection and SAFIRE (Group B Purpose: Cerebral small vessel disease (SVD) is a common cause of cognitive impairment. Overall average score of SSF reconstructed segments was significantly higher compared with STD reconstruction ( Purpose: To evaluate the feasibility and imaging quality of double prospectively ECG-triggered high-pitch spiral acquisition mode for coronary computed tomography angiography (CTCA) in patients with atrial fibrillation (AF). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666652/ doi: 10.1007/s13244-013-0228-x id: cord-001221-due9tloa author: nan title: ECR 2014, Part A date: 2014-02-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948175/ doi: 10.1007/s13244-014-0316-6 id: cord-002774-tpqsjjet author: nan title: Section II: Poster Sessions date: 2017-12-01 words: 83515.0 sentences: 5162.0 pages: flesch: 54.0 cache: ./cache/cord-002774-tpqsjjet.txt txt: ./txt/cord-002774-tpqsjjet.txt summary: Results: The CHIP Framework The CHIP framework aims to improve the health and wellness of the urban communities served by St. Josephs Health Centre through four intersecting pillars: • Raising Community Voices provides an infrastructure and process that supports community stakeholder input into health care service planning, decision-making, and delivery by the hospital and across the continuum of care; • Sharing Reciprocal Capacity promotes healthy communities through the sharing of our intellectual and physical capacity with our community partners; • Cultivating Integration Initiatives facilitates vertical, horizontal, and intersectoral integration initiatives in support of community-identified needs and gaps; and • Facilitating Healthy Exchange develops best practices in community integration through community-based research, and facilitates community voice in informing public policy. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711696/ doi: 10.1093/jurban/jti137 id: cord-003532-lcgeingz author: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423782/ doi: 10.1186/s13054-019-2358-0 id: cord-004675-n8mlxe7p author: nan title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2019-02-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086569/ doi: 10.1007/s10875-019-00597-5 id: cord-004894-75w35fkd author: nan title: Abstract date: 2006-06-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087564/ doi: 10.1007/s10654-006-9021-1 id: cord-005105-twsy61oq author: nan title: SIU 2015 Abstracts date: 2015-09-21 words: 124096.0 sentences: 7584.0 pages: flesch: 54.0 cache: ./cache/cord-005105-twsy61oq.txt txt: ./txt/cord-005105-twsy61oq.txt summary: Th e present study is based on a retrospective analysis of a database of over 600 patients (age range 17-57 years) who met the consensus criteria for bacterial prostatitis, 75% of whom had dysuria, 35% perineal discomfort, 60% had obstructive luts, 37% infertility of unknown etiology, 10% erectile dysfunction and 25% recurrent infection of the partner. Further research is needed to determine to assess whether localization of small volume disease on 68Ga-PSMA PET/CT can improve diagnostic algorithms and outcomes in patients with recurrent PCa. Introduction and Objective: To assess long-term results of salvage pelvic lymph node dissection (PLND) in prostate cancer (PC) patients (pts) with biochemical recurrence aft er primary local treatment and confi rmed solitary lymph node (LN) metastases. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088373/ doi: 10.1007/s00345-015-1684-3 id: cord-005147-mvoq9vln author: nan title: Autorenregister date: 2017-02-23 words: 86573.0 sentences: 4356.0 pages: flesch: 45.0 cache: ./cache/cord-005147-mvoq9vln.txt txt: ./txt/cord-005147-mvoq9vln.txt summary: Using whole-exome sequencing and trio-based de novo analysis, we identified a novel heterozygous de novo frameshift variant in the leukemia inhibitory factor receptor (LIFR) gene causing instability of the mRNA in a patient presenting with bilateral CAKUT and requiring kidney transplantation at one year of age. Loss of cdkl5 associated with deficient mammalian target of rapamycin (mTOR) signaling in mice and human cells We and other groups have shown that mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a severe neurodevelopmental disorder with clinical features including intellectual disability, early-onset intractable seizures and autism, that are closely related to those present in Rett syndrome (RTT) patients. Functional characterization of novel GNB1 mutations as a rare cause of global developmental delay Over the past years, prioritization strategies that combined the molecular predictors of sequence variants from exomes and genomes of patients with rare Mendelian disorders with computer-readable phenotype information became a highly effective method for detecting disease-causing mutations. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088617/ doi: 10.1007/s11825-017-0126-6 id: cord-005453-4057qib7 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 words: 275771.0 sentences: 16876.0 pages: flesch: 56.0 cache: ./cache/cord-005453-4057qib7.txt txt: ./txt/cord-005453-4057qib7.txt summary: To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091813/ doi: 10.1038/s41409-019-0559-4 id: cord-005460-ezrn8cva author: nan title: Physicians – Poster Session date: 2017-07-28 words: 287105.0 sentences: 15681.0 pages: flesch: 56.0 cache: ./cache/cord-005460-ezrn8cva.txt txt: ./txt/cord-005460-ezrn8cva.txt summary: Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091844/ doi: 10.1038/bmt.2017.134 id: cord-005478-5iu38pr6 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date: 2019-07-03 words: 63350.0 sentences: 3869.0 pages: flesch: 58.0 cache: ./cache/cord-005478-5iu38pr6.txt txt: ./txt/cord-005478-5iu38pr6.txt summary: There were some differences among groups: patients in group-1 were younger (median age 46 years, p< 0.02) were transplanted in more recent year (2015, p< 0.001), received more frequently a regimen based on TBF (thiotepa, fludarabine and busulfan) (83%, p< 0.001) and bone marrow (BM) as source of stem cells (77%, p< 0.001), with no ATG (100%, p< 0.001). Clinical Trial Registry: NCT01217723 Disclosure: None of the Authors have any conflicts of interest to declare O105 Immune reconstitution -based score at diagnosis of CGVHD predicts GVHD severity and overall-survival: A novel prognostication tool for GVHD treatment tailoring Background: Allogeneic stem cell transplantation (HSCT) survivors are at a relevant risk of developing chronic GvHD (cGvHD), which importantly affects quality of life and increases morbidity and mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092200/ doi: 10.1038/s41409-019-0562-9 id: cord-005480-yg7salqt author: nan title: Oral Sessions and Working Party date: 2008-03-26 words: 72626.0 sentences: 3873.0 pages: flesch: 55.0 cache: ./cache/cord-005480-yg7salqt.txt txt: ./txt/cord-005480-yg7salqt.txt summary: Standard NIH or Eurolupus cyclophosphamide (CY) protocols and mycophenolate Mofetil (MMF) as induction therapy in severe BILAG A SLE is still associated with 20 % failure, 50% relapse and 10% to 15 % death at 10 years In the absence of a single standard treatment worldwide for refractory SLE, phase I-II studies analysed the use of: a) rituximab (anti CD20 mAb) in more than 1 000 patients showing complete to partial early response around 100% with relapse in 50 to 60% of the cases; b) autologous Hematopoietic Stem Cell Transplantation (HSCT) since 1997 under the auspices of the joined EBMT-EULAR working party, reporting durable remission with reduced or no immunosuppressive drug requirement in 66%, one-third of whom later relapsed to some degree with a 74 ± 7% (n= 62/79) overall survival at 5 years for SLE among the 863 HSCT procedures registered: in 2007 in the EBMT data base. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092258/ doi: 10.1038/bmt.2008.30 id: cord-005482-v5iayczy author: nan title: Publication Only date: 2016-03-21 words: 27400.0 sentences: 1715.0 pages: flesch: 54.0 cache: ./cache/cord-005482-v5iayczy.txt txt: ./txt/cord-005482-v5iayczy.txt summary: Material (or patients) and methods: Case Report 23-year-old male patient who underwent allogeneic hematopoietic stem cell tranplantation sixteen months ago, admitted to bone marrow transplantation clinic for shortness of breath. Material (or patients) and methods: Data sets of 436 consecutive patients who underwent allogeneic HSCT at a single center (University of Rostock) from 1998 to 10/2015 were analysed regarding their early mortality rates (d+30, d+60 Introduction: Mobilization and collection of CD34-positive stem cells for subsequent high-dose chemotherapy constitutes a standard approach in myeloma patients achieving a good remission after induction chemotherapy. Outcomes of high grade gastrointestinal gvhd post-hsct in children Material (or patients) and methods: This is a retrospective analysis of 28 pediatric patients presented with a clinical diagnosis of stage 3 and 4 acute GVHD of the GIS who were selected from allogeneic hematopoetic stem cell transplantation (HSCT) performed. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092319/ doi: 10.1038/bmt.2016.56 id: cord-005487-vac061r8 author: nan title: Physicians Abstracts: EBMT 2010 date: 2010-04-07 words: 58975.0 sentences: 3128.0 pages: flesch: 58.0 cache: ./cache/cord-005487-vac061r8.txt txt: ./txt/cord-005487-vac061r8.txt summary: We retrospectively analyzed 1257 patients (pts), 755 children (age≤18) and 502 adults, receiving fi rst single (n = 1080) or double UCBT (n = 177) in EBMT centers, between 1995 and 2009 , for malignant and non-malignant diseases, who survived at least 100 days from transplantation with neutrophils recovery and without relapse or autologous reconstitution. Prochymal® improves response rates in patients with steroid-refractory acute graft-versus-host disease involving the liver and gut: results of a randomized, placebo-controlled, multicentre phase III trial in GvHD P.J. Martin (1) , J.P. Uberti (2) Background and methods: Steroid-refractory acute GVHD (SR-GVHD) remains a signifi cant and life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). A. Nagler (1) Background: Allogeneic transplantation of hematopoietic stem cells (allo-SCT) from an HLA-matched related (MRD) or unrelated donor (URD) is a curative option for patients (pts) with high-risk hematological disease (HRHD). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092333/ doi: 10.1038/bmt.2010.40 id: cord-005497-w81ysjf9 author: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103623.0 sentences: 6176.0 pages: flesch: 53.0 cache: ./cache/cord-005497-w81ysjf9.txt txt: ./txt/cord-005497-w81ysjf9.txt summary: The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092506/ doi: 10.1186/s13054-020-2772-3 id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72031.0 sentences: 4734.0 pages: flesch: 56.0 cache: ./cache/cord-005646-xhx9pzhj.txt txt: ./txt/cord-005646-xhx9pzhj.txt summary: Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer''s exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095092/ doi: 10.1007/bf02316512 id: cord-005727-li8pwigg author: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 words: 102770.0 sentences: 6408.0 pages: flesch: 53.0 cache: ./cache/cord-005727-li8pwigg.txt txt: ./txt/cord-005727-li8pwigg.txt summary: Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095301/ doi: 10.1007/s00134-010-1999-x id: cord-005777-6rvfsx4p author: nan title: PS 0420-0716 date: 2007-08-25 words: 59217.0 sentences: 3634.0 pages: flesch: 53.0 cache: ./cache/cord-005777-6rvfsx4p.txt txt: ./txt/cord-005777-6rvfsx4p.txt summary: We prospectively recorded data of all patients who were newly diagnosed with AF and all those with a septic shock on a surgical ICU (no cardiac surgery) during a one year period according to the requirements of the local ethical committee. Our aim was to evaluate the predictive role of admission APACHE II, admission and total maximum SOFA score, hypoalbuminemia, increased serum creatinine, C-reactive protein, lactate, and serum blood glucose for the 30-day mortality of septic patients admitted to medical ICU. The aim of this study was to analyze the clinical presentation and to evaluate mortality associated factors (timing and accurancy of diagnosis, timing of surgery, severity score and organ failure, surgical and medical treatments). Data were extracted independently to assess intention to treat intensive care unit (ICU) and hospital mortality, days of mechanical ventilation, length of stay, incidence of ventilator-associated pneumonia and pneumothorax, and associated complications of the implemented intervention. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095424/ doi: 10.1007/s00134-007-0823-8 id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179164.0 sentences: 12028.0 pages: flesch: 56.0 cache: ./cache/cord-005814-ak5pq312.txt txt: ./txt/cord-005814-ak5pq312.txt summary: Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095534/ doi: 10.1007/bf02426401 id: cord-005816-i54q5gsu author: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 words: 83124.0 sentences: 5617.0 pages: flesch: 53.0 cache: ./cache/cord-005816-i54q5gsu.txt txt: ./txt/cord-005816-i54q5gsu.txt summary: Several factors such as the initial lack of symptoms, a low diagnostic sensitivity of the CT (34% false negatives), and the nonoperative management of solid organ injuries, have contributed to a delayed diagnosis in one of every five patients in our series, but this has not led to a significant increase in septic complications in this group. Method: The demographic features, the treatments, the intensity of the illness and mortality rate of the 155 patients in Afyon Kocatepe University General Surgery clinic between the years 2006 Background: Enterocutaneous fistula continues to be a serious surgical problem. Introduction: In our previous study, we examined the treatment results of burn patients older than 45 years, and found a significant increase in mortality with increasing age groups. Methods: Data on emergency surgical cases and admissions to the surgical service over a 3-month period were collected and analyzed; this included patient demographics, referral sources, diagnosis, operation, and length of stay (LOS Conclusion: Emergency workload represents a significant part of the work for the general surgeons. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095784/ doi: 10.1007/s00068-009-8001-z id: cord-005881-oswgjaxz author: nan title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 words: 71955.0 sentences: 4561.0 pages: flesch: 52.0 cache: ./cache/cord-005881-oswgjaxz.txt txt: ./txt/cord-005881-oswgjaxz.txt summary: Prospective case series with historical control group.(Level III) Results: Preliminary data indicate: *a shorter time on ventilator than anticipated (based on comparisson to historical data) * a shorter time on ICU * less pneumoniae * no intra-operative complications * good healing results of the rib fractures * no implant failures * acceptable pain scores * good overal satisfaction * acceptable cosmetic results Conclusion: Internal fixation of rib fractures (flair chest or multiple sequential fractures with pulmonary function compromise) results in a earlier recuperation of pulmonary function with shortened ICU stay. (Regional Association Sanitary Emergencies) Material and Methods: The ARES, whose members are about 600, all over the nation, is configured as an extraordinary health resource, activated by the National Civil Defence operations centre, in according with the Regional centre of Marche, in disater situations Results: The main objectives of ARES are training and organization of medical staff and structures and its growth crosses several missions including: AE Earthquake in Molise, 2002 Introduction: Cephalomedullary nails rely on a large lag screw that provides fixation into the femoral head. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095891/ doi: 10.1007/s00068-010-8888-z id: cord-005953-5z89yeb6 author: nan title: Abstracts des 114. Internistenkongresses 2008 date: 2008 words: 16135.0 sentences: 1522.0 pages: flesch: 49.0 cache: ./cache/cord-005953-5z89yeb6.txt txt: ./txt/cord-005953-5z89yeb6.txt summary: Die anderen beiden Gruppen zeigten zwar in Hinblick auf die Wandstärken einen positiven Effekt, hinsichtlich der Herzfunktion konnten sie jedoch bei bereits deutlich erniedrigten Funktionswerten zum Baseline-Zeitpunkt lediglich stabilisiert werden (Reduktion der Wandstärke nach 3 Jahren ERT: Gruppe wenig Fibrose= 10 mm; Gruppe viel Fibrose= 12 mm) Schlussfolgerung: Die Enzymersatztherapie ist eine effektive Langzeitbehandlung bei Patienten mit Fabry Kardiomyopathie. Der Einfluss der sauren Sphingomyelinase auf die Expression von Matrix-Metalloproteinase-1 in intestinalen Epithelzellen und Fibroblasten Background: The calcineurin (Cn)/NF-AT signaling cascade takes a crucial role during T-cell activation and the development of myocardial hypertrophy. Effective and safe reduction of blood pressue by the combination of amlodipine 5/valsartan 160 mg in patients with hypertension and metabolic risk factors not controlled by amlodipine 5 mg or felodipine 5 mga subanalysis of the express-m trial Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia and frequently occurs in patients with coronary heart disease. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096012/ doi: 10.1007/s00063-008-1026-y id: cord-005992-mu917isy author: nan title: Abstracts der 49. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date: 2011-10-23 words: 19250.0 sentences: 2049.0 pages: flesch: 52.0 cache: ./cache/cord-005992-mu917isy.txt txt: ./txt/cord-005992-mu917isy.txt summary: Es bleiben aber eine Reihe von IH übrig, welche an weniger auffälligen Lokalisationen sind, bei sehr jungen Säuglingen gerade im Entstehen, und solche bei denen die Relation zu einer systemischen Therapie grenzwertig ist. Auf Grund einer initial als Mutation beschrieben Veränderung des HNF1a Gens wurde die Diagnose MODY 3 gestellt und die Therapie von Insulin auf Sulfonylharnstoff umgestellt. SSW Der Patient zeigt ein sehr auffälliges Trinkverhalten (beim Trinken kommt es zum Zurückfließen von Milch aus dem Mund) sowie einen in-und exspiratorischen Stridor, die durchgeführten Untersuchungen bleiben jedoch ohne pathologischen Befund. Wir konnten auch zeigen, dass insbesondere bei Kindern mit B-Zellvorläufer ALL die Kombination von beiden MRD-Zeitpunkten prognostisch bedeutsam ist, da zum Beispiel Patienten mit einer MRD von ≥10 −3 am Tag 33 und jeglichem positivem Signal am Tag 78 ein schlechtes Ergebnis vorwiesen. In einer Pilotstudie konnten wir zeigen, dass durch Modifikation der Probenaufbereitung ein Einsatz des Roche Septifast-Systems bei Frühgeborenen mit einem geringen Blutvolumen von minimal 100 µl möglich ist. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096095/ doi: 10.1007/s00112-011-2508-1 id: cord-006182-kck5e1ry author: nan title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date: 2019-10-01 words: 87645.0 sentences: 4817.0 pages: flesch: 46.0 cache: ./cache/cord-006182-kck5e1ry.txt txt: ./txt/cord-006182-kck5e1ry.txt summary: The primary objective of COGiTATE (CppOpt GuIded Therapy Assessment of Target Effectiveness) is to demonstrate feasibility of individualising CPP at CPPopt in TBI patients, expressed as the percentage of monitoring time for which CPP is within 5 mmHg of regularly updated CPPopt targets during the first 5 days of Intensive Care Unit (ICU) admission. Neurocritical care has become increasingly subspecialized.Yet, due to limited availability of dedicated Neurocritical Care units (NCCUs), often patients may need to be admitted to ICUs other than NCCUs. This survey based study was conducted to explore self-reported knowledge in recognizing and managing some common neurological emergencies such as stroke, status epilepticus, raised intracranial pressure etc among critical care nurses at a Comprehensive Stroke Center. Coagulation factor Xa (recombinant), inactivated-Xa inhibitor associated life--factor prothrombin complex concentrate (PCC) was utilized offRetrospective, single center, cohort study including adult intracranial hemorrhage patients who received discharge between efficacy (defined by International Society on Thrombosis and Haemostasis criteria), thrombotic events, ICU and hospital length of stay, and mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100118/ doi: 10.1007/s12028-019-00857-7 id: cord-006226-fn7zlutj author: nan title: Abstracts of the 4th annual meeting of the German Society of Clinical Pharmacology and Therapy: Hannover, 14–17 September 1994 date: 1994 words: 25050.0 sentences: 1344.0 pages: flesch: 50.0 cache: ./cache/cord-006226-fn7zlutj.txt txt: ./txt/cord-006226-fn7zlutj.txt summary: The following were analysed: heart rate (HR, bpm), pre-ejection time (PEP, ms), ejection time (VET, ms), HR-corrected electromechanical systole (QS2c, ms), impedance-cardiographic estimates of stroke volume (SV, ml), cardiac output (CO, I/min) and peripheral resistance (TPR, dyn.s.cm -5) calculated from CO and mean blood pressure (SBP and DBP according to auscultatory Korotkoff-I and -IV sounds This indicates that 1) about half the rise of HR and CO and half the shortening of PEP is 131-respectively 1~2-determined, 2) that predominant 132-adrenergic responses, whilst not affecting VET, take optimal benefit from the inodilatory enhancement of pump performance, 3) that an additional 131-adrenergic stimulation is proportionally less efficient, as VET is dramatically shortened, thus blunting the gain in SV so that the rise in CO relies substantially on the amplified increase of HR and 4), VET is more sensitive than QS2c in expressing additional 131-adrenoceptor agonism and 5) prime systolic time intervals provide a less speculative and physiologically more meaningful represenation of cardiac pump dynamics than HR-corrected ones. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100636/ doi: 10.1007/bf00193489 id: cord-006236-2gpwf4z2 author: nan title: Abstracts from the First International Conference on Heart Failure in Children and Young Adults date: 2004 words: 13113.0 sentences: 882.0 pages: flesch: 55.0 cache: ./cache/cord-006236-2gpwf4z2.txt txt: ./txt/cord-006236-2gpwf4z2.txt summary: Key words: Gene Expression, Ventricular Hypertrophy, and Congenital Heart Disease Background: Extracorporeal membrane oxygenation (ECMO) can be used to support children with severe graft failure after heart transplant (Tx). In the 2 pts with graft failure from acute rejection, ECMO duration was 5 and 6 days; both regained normal heart function and were successfully decannulated without complications. Key words: ECMO, Heart Transplant, Graft Failure, Acute Hemodynamic Rejection Background: Ventricular assist device (VAD) support is well established in treating adults with end-stage heart disease. Key words: Mechanical circulatory support, Pediatric, VAD, Congenital Heart Disease, and Cardiomyopathy Background: Measurement of whole blood B-type natriuretic peptide (BNP) levels has been shown to detect heart failure in adults presenting with dyspnea in the acute setting. Key words: levosimendan, heart failure, cardiomyopathy Methods: 20 children were studied, age range from 2 to 192 months (median 32.5 months). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100653/ doi: 10.1007/s00246-004-2553-9 id: cord-006391-esnsa4u5 author: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 words: 44844.0 sentences: 2433.0 pages: flesch: 50.0 cache: ./cache/cord-006391-esnsa4u5.txt txt: ./txt/cord-006391-esnsa4u5.txt summary: In our parallel tests using an excision-sample technique [2] which is considerably more sensitive than the DGHM procedure, we have observed the following mean reductions in the counts of accessible bacteria: iodine in ethanol, 96%; povidone-iodine, 89%; chlorhexidine in ethanol, 88%; iso-propanol, The purpose of this study was to compare radiation injury in Guinea Pig small bowel (1) devoid of contents (2) containing bile (3) containing pancreatic juice. Studies in vitro employing isolated perfused rat pancreas and stomach revealed following results: Mean basal pancreatic somatostatin release in normal, diabetic and transplanted rats were 12___3, 24-t-7, and 17__+4 pg/ml, respectively. As these changes appear closely correlated to the blood glucose levels which show a 30 % decrease at 4 h and progressive restoration towards normal values up to 24 h, attempts have been made to alter the insulin/glucagon ratio by glucose infusion after PH and study its relation to liver regeneration. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101735/ doi: 10.1007/bf01279099 id: cord-006444-eq56zhtd author: nan title: Abstracts of oral presentations and posters date: 1993 words: 40668.0 sentences: 2121.0 pages: flesch: 53.0 cache: ./cache/cord-006444-eq56zhtd.txt txt: ./txt/cord-006444-eq56zhtd.txt summary: The results from ongoing preclinical studies continue to confirm the broad spectrum of biological activities possessed by rhiL-1 1 in vitro and suggest this cytokine may be an effective agent in the treatment of myelosuppression associated with cancer chemotherapy and bone marrow transplantation. We performed a phase H trial to assess the ability of G-CSF -mobilized PBPC to rapidly and completely restore hemopeiesis after high dose chemotherapy in the absence of bone marrow infusions, with selection for PBPC-only infusions based on yield of granulocyte -macrophage colony -forming cells (GM-CFC) after G-CSF treatment. Our approach for high-dose (HD) chemotherapy is to first treat patients eligible for dose intensification with a standard dose chemotherapy (VIP: VP26 = etoposide: 500 mg/m 2, ifosfamide: 4 g/m 2, cis-platinum: 50 mg/m 2) followed by the application of colony stimulating factors (G-CSF, GM-CSF or IL-3 + GM-CSF) in order to combine a regimen with broad anti-tumor activity with the recruitment of peripheral blood progenitor cells (PBPCs). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101830/ doi: 10.1007/bf01695978 id: cord-006466-e1phpqes author: nan title: 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2018-04-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101862/ doi: 10.1007/s10875-018-0485-z id: cord-006563-qmigctkp author: nan title: The abstracts of the 26th congress of ESCTAIC, Timisoara, Romania, September 22–24 2016 date: 2017-03-07 words: 8628.0 sentences: 416.0 pages: flesch: 44.0 cache: ./cache/cord-006563-qmigctkp.txt txt: ./txt/cord-006563-qmigctkp.txt summary: This is the reason why in the last decades a lot of clinical studies have been performed with the aim of reducing the magnitude of the postoperative pain, all of them directed to those factors which might influence the pain after surgery, such as: presence of preoperative chronic pain, anesthesia technique, or the need for an acute pain service. The list of proposals to be taken into consideration includes: a careful psychological evaluation and preparation of the surgical patient, a good preoperative sedation and even the use of antidepressants before surgery in specific cases. Regional anesthesia and ambulatory surgery: the role of continuous infusion devices in postoperative pain management in pediatrics Ralph J Beltran Department of Anesthesiology and Pain Medicine, Nationwide Children''s Hospital, Columbus, Columbus, OH, USA Continuous infusions of local anesthetic delivered via peripheral nerve block catheters (PNB) for postoperative pain management in adult patients has become more prevalent. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102034/ doi: 10.1007/s10877-017-9991-4 id: cord-006702-ekf6mja9 author: nan title: Abstracts for the 17th IPNA Congress, Iguaçu, Brazil, September 2016: Oral Presentations date: 2016-08-17 words: 23229.0 sentences: 1404.0 pages: flesch: 52.0 cache: ./cache/cord-006702-ekf6mja9.txt txt: ./txt/cord-006702-ekf6mja9.txt summary: After correction using the optimal linear regression, the variability of the measurements was examined using Bland-Altman plots Results: We studied 29 patients (17 male, 12 female) with a median age (SD) of 14.0 (3.4) years and eGFR 111 (17) Objectives: Mutations of the Pkhd1 gene cause autosomal recessive polycystic kidney disease (ARPKD). Objectives: To examine the characteristics, follow up and availability of long term outcome data in a cohort of New Zealand children with acute kidney injury (AKI) requiring renal replacement therapy (RRT) following cardiac surgery at Starship Hospital over a six-year period. Methods: Cohort study conducted from 2008-2012 of 57 female patients age 9-21 years recruited from 2 pediatric nephrology clinics with CKD (n=25), on dialysis (n=9), or status post kidney transplantation (n=23) who received the standard 3-dose vaccine series of the HPV vaccine. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102258/ doi: 10.1007/s00467-016-3466-6 id: cord-006828-i88on326 author: nan title: Abstracts DGRh-Kongress 2013 date: 2013-09-15 words: 30772.0 sentences: 2576.0 pages: flesch: 52.0 cache: ./cache/cord-006828-i88on326.txt txt: ./txt/cord-006828-i88on326.txt summary: Comparing gene expression profiles of yellow fever immunized individuals and active SLE patients it was possible to identify a "common" and an "autoimmune-specific" IFN signature. The inflammatory and profibrotic effects upon Aab stimulation in vitro, and their associations with clinical findings suggest a role for autoantibody-mediated activation of immune cells mediated through the AT1R and ETAR in the pathogenesis or even the onset of the disease. This study was aimed to investigate the humoral and cellular immune response to VZV including assessment of IgG-anti-VZV avidity and VZV-specific reactivity of lymphocytes in RA (n=56) or JIA patients (n=75) on different treatments, including biologic agents, such as anti-tumor-necrosis-factor(TNF)-alpha or anti-interleukin-6 (IL-6) receptor inhibition (tocilizumab), compared to 37 healthy adults (HA) and 41 children (HC). Production of cytokines by B cells in response to TLR9 stimulation inversely correlates with disease activity in SLE-patients abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103148/ doi: 10.1007/s00393-013-1255-1 id: cord-006849-vgjz74ts author: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 words: 222162.0 sentences: 14023.0 pages: flesch: 48.0 cache: ./cache/cord-006849-vgjz74ts.txt txt: ./txt/cord-006849-vgjz74ts.txt summary: Methods: We are performing this procedures within a prospective randomized trial that is design to compare the long term results of LRYGB-B versus the standard laparoscopic Roux-en-Y gastric bypass.The video shows our technique in a case of a 46 years old female with a BMI of 46 Kg/m2. Material and methods: We present a video of the surgical intervention of a 32-year-old patient, with functional dyspepsia, with a casual diagnosis of a pseudocystic mass of the right colon after performing a CT scan: giant diverticulum of the hepatic colon angle with fecaloid content inside it under tension The patient goes to the emergency room for acute abdominal pain, pending colonoscopy, antibiotic treatment is established, and a laparoscopic approach is decided upon after the patient''s evolution. Method: We present the case of a 65-year-old patient with surgical antecedent of laparoscopic low anterior resection due to rectal cancer, presenting in postoperative period an anastomosis leakage with severe peritonitis was identified and a laparotomy with end colostomy was performed. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103177/ doi: 10.1007/s00464-019-07109-x id: cord-006854-o2e5na78 author: nan title: Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date: 2018-04-20 words: 166047.0 sentences: 10353.0 pages: flesch: 47.0 cache: ./cache/cord-006854-o2e5na78.txt txt: ./txt/cord-006854-o2e5na78.txt summary: Totally Laparoscopic ALPPS Combined with the Microwave Ablation for a Patient with a Huge HCC Hua Zhang; Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University Introduction: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel technique for resecting hepatic tumors that were previously considered unresectable due to the insufficient future liver remnant (FLR) which may result in postoperative liver failure (PLF). Not only does this case show that a large epiphrenic diverticulm can be successfully resected via the trans-abdominal laparoscopic approach, this case makes the argument that patients undergoing any minimally-invasive epiphrenic diverticulectomy and myotomy, with or without fundoplication, may be successfully managed with early post-operative contrast studies and dietary advancement, thus decreasing their length of hospitalization and overall cost of treatment. Introduction: There are reports of increased operative duration, blood loss and postoperative morbidity, caused by difficulties in obtaining good visualization and in controlling bleeding when laparoscopic resection is performed in obese patients with colon cancer. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103183/ doi: 10.1007/s00464-018-6121-4 id: cord-006856-b1w25ob5 author: nan title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date: 2005 words: 29625.0 sentences: 1983.0 pages: flesch: 52.0 cache: ./cache/cord-006856-b1w25ob5.txt txt: ./txt/cord-006856-b1w25ob5.txt summary: Egr-1 and hypoxia-inducible factor-1 (HIF-1) gene expression was examined in left ventricular biopsies of explanted failing hearts in 28 ICM and 42 DCM patients, as well as in 12 donor grafts before reperfusion (control), at 10, 30, 60 minutes after reperfusion, and at 1, 2, 3, 4, 6, 12 posttransplant weeks, using real-time RT-PCR. The risk of transplant-related mortality (TRM) due to graft-versushost disease (GvHD) is higher in male recipients of female stem cells compared with female patients receiving a graft from a female donor. We therefore analyzed a single-center cohort of 72 high-risk patients transplanted with a related or unrelated stem cell graft after nonmyeloablative conditioning for outcome (acute and chronic GvHD, TRM, relapse, and survival). Four patients between the age of 34 and 44 years underwent allogeneic peripheral blood stem cell (PBSC) transplantation (SCT) from HLA-identical sibling or unrelated donors at our institution. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103192/ doi: 10.1007/s10353-005-0216-6 id: cord-006860-a3b8hyyr author: nan title: 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date: 1996 words: 90660.0 sentences: 5152.0 pages: flesch: 50.0 cache: ./cache/cord-006860-a3b8hyyr.txt txt: ./txt/cord-006860-a3b8hyyr.txt summary: Dept of Pediatrics, University Hospitals Kiel and Mtinster, Germany Resistance to activated protein C (APCR), in the majority of cases associated with the Arg 506 Gin point mutation in the factor V gene is present in more than 50 % of patients < 60 years of age with unexplained thrombophilia. The regular APC resistance test is not applicable to plasma from Orally anticoagulated (OAC) or heparinized patients due to decreased levels of vitamin K-dependent clotting factors and to thrombin inhibition by antithrombin, respectively. On admission an extensive coagulation screen yielded the following results (n/normal, t/elevated, I/reduced, +/positive, -/negative): PT t, aPTT t, Tr n, factor II, V, VIII n, factor VII, IX, XI, XII /,, fibrinogan t, ATIII n, protein C, S *, activated protein C sensitivity ratio 1.92 ($), FV-Leidenmutation PCR -, fibrinolytic system n, TAT t, Ft÷2 t, lupus anticoagulant +, heparin induced platelet antibodies +; no diagnosis of a specific autoimmuna disorder could be made. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103196/ doi: 10.1007/bf00641048 id: cord-006862-5va1yyit author: nan title: ITS ASM 2012 date: 2012-11-04 words: 25959.0 sentences: 1689.0 pages: flesch: 52.0 cache: ./cache/cord-006862-5va1yyit.txt txt: ./txt/cord-006862-5va1yyit.txt summary: 10 .45 % (n = 202) of attendances were for non-respiratory diseases as the clinic also provides follow-up for general medical patients post hospital admission. Higher levels of exercise participation were seen in the younger age groups (p = 0.585 Introduction: Respiratory diseases, largely represented by COPD, are the third most common cause of acute hospital admission.Our aim was to audit the prescribing habits of inhaled, nebulised medication and oxygen by doctors in a general hospital. Our study was designed to determine the baseline and post-treatment values of total lymphocyte count and its subsets in HIV-negative patients diagnosed with active pulmonary MTB. The results of this study indicate that AAT can inhibit LTB 4 signaling thereby reducing the proteolytic activity of neutrophils and propose AAT aerosolized augmentation therapy as an effective treatment for LTB 4 associated pulmonary diseases including cystic fibrosis and severe asthma. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103221/ doi: 10.1007/s11845-012-0856-z id: cord-006869-g2q1gpp0 author: nan title: Neurocritical Care Society 7th Annual Meeting date: 2009-10-08 words: 45395.0 sentences: 2661.0 pages: flesch: 49.0 cache: ./cache/cord-006869-g2q1gpp0.txt txt: ./txt/cord-006869-g2q1gpp0.txt summary: This was a pilot study to compare the cerebral neurochemical changes in patients with traumatic brain injury (TBI) who underwent conventional blood glucose level (BGL) control and intensive BGL control with continuous titrated insulin. We studied 14 comatose SAH patients who underwent multimodality neuromonitoring with intracranial pressure (ICP), cerebral microdialysis, and brain tissue oxygen (PbtO 2 ) as part of their clinical care. We studied 46 consecutive comatose patients with subarachnoid or intracerebral hemorrhage, traumatic brain injury, or cardiac arrest who underwent cerebral microdialysis and intracranial pressure monitoring.Continuous insulin infusion was used to maintain target serum glucose levels of 80-120 mg/dl. This suggests that risk of cerebral vasospasm following traumatic brain injury is increased not only in subarachnoid hemorrhage, but also intraparenchymal hemorrhage, and that Rotterdam CT score may be a useful metric for assessing risk of csPTV in severe TBI patients. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103236/ doi: 10.1007/s12028-009-9282-0 id: cord-006870-f5w6fw6q author: nan title: Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date: 2017-09-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103238/ doi: 10.1007/s12028-017-0465-9 id: cord-006876-v2m5l5wz author: nan title: Neurocritical Care Society 14(th) Annual Meeting date: 2016-08-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103251/ doi: 10.1007/s12028-016-0301-7 id: cord-006880-9dgmdtj8 author: nan title: Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date: 2012-09-19 words: 82351.0 sentences: 4528.0 pages: flesch: 49.0 cache: ./cache/cord-006880-9dgmdtj8.txt txt: ./txt/cord-006880-9dgmdtj8.txt summary: Patients initially comatose after cardiac arrest treated who awoke after therapeutic hypothermia (TH) were evaluated by a neuropsychologist prior to hospital discharge with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a well-validated tool that assesses function in multiple domains compared to standardized normal values. Clinical data including the pre-admission-status, neuroradiological, initial presentation, treatment, and outcome were evaluated through institutional databases, patient''s medical charts and by mailed questionnaires. To determine the differences in hospital outcomes among adult mild traumatic brain injury (TBI) patients where the severity of TBI is defined by Glasgow Coma Scale (GCS) score. Retrospective chart analysis was performed on all adult patients arriving to emergency department with history of fall at a level one trauma center for parameters like vomiting, alteration of consciousness (AOC) & loss of consciousness (LOC) after TBI; post-traumatic amnesia (PTA) and history of seizures before or after injury, along with outcomes such as ICU admission & ICU length of stay. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103259/ doi: 10.1007/s12028-012-9775-0 id: cord-006882-t9w1cdr4 author: nan title: Royal Academy of Medicine in Ireland date: 2012-07-22 words: 13704.0 sentences: 858.0 pages: flesch: 52.0 cache: ./cache/cord-006882-t9w1cdr4.txt txt: ./txt/cord-006882-t9w1cdr4.txt summary: Objective: The aim of this study was to develop a mathematical model to determine the TTO based on two or more DEXA scans with TTO defined as the age at which the patient will enter the osteoporotic T-score range. An Audit of Clinical Outcomes in Transcervical Resection of the Endometrium Compared to Outpatient Balloon Thermablation Anglim BC, Von Bunau G Department of Gynaecology, Adelaide and Meath Children''s Hospital, Tallaght, Dublin Thermablation was introduced to the Coombe in November 2009 and thus far it has provided a quick and effective means of treating women with menorrhagia refractive to medical treatment. This audit reviewed cases of ovarian cystectomy, oopherectomy and salpingooopherectomy using both a hospital online database and records of theatre procedures to identify these patients. A retrospective review of the case notes of patients aged greater than 80 years who underwent bronchoscopy between September 2009 and November 2011 was carried out. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103265/ doi: 10.1007/s11845-012-0833-6 id: cord-006888-qfnukav4 author: nan title: Irish Thoracic Society Annual Scientific Meeting, Ramada Hotel, Belfast: 7th–8th November 2008 date: 2008-10-21 words: 30369.0 sentences: 1866.0 pages: flesch: 53.0 cache: ./cache/cord-006888-qfnukav4.txt txt: ./txt/cord-006888-qfnukav4.txt summary: 2 This study explored anxiety, depression and QoL of a small group of patients (n = 5), predominantly male (66.7%), mean age 74 years, using the Marie Curie ''''breathing space'''' outpatient clinic over a four week period. Methods: CF patients attending CUH completed a questionnaire relating to personal smoking and second-hand smoke (SHS) exposure, correlated with pulmonary function and exacerbation-rate data. This ongoing study indicates that a clinical pharmacy led management programme can reduce the need for hospital care in patients with moderate-to-severe COPD and improve aspects of their health related quality of life. There is a need for wider availability of joint hospital/ community based initiatives such as COPD Outreach and PRPs. Pulmonary rehabilitation has established efficacy, but patients often require follow-up care or maintenance. Patient data (MDS/ISWT/endurance shuttle walking test(ESWT)) from our pulmonary rehabilitation programme were initially analysed (n = 214; median FEV 1 = 1.04 L; mean age = 69 yrs). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103299/ doi: 10.1007/s11845-008-0235-y id: cord-006924-1i3kf01j author: nan title: Abstracts from USCAP 2020: Pulmonary, Mediastinum, Pleura, and Peritoneum Pathology (1869-1980) date: 2020-03-05 words: 25334.0 sentences: 1479.0 pages: flesch: 50.0 cache: ./cache/cord-006924-1i3kf01j.txt txt: ./txt/cord-006924-1i3kf01j.txt summary: Results: Patients'' characteristics of 77 cases were as following; median age was 60 years old (range 33-77); 67 male and ten female; 16/16/41/4 of clinical Stage I/II/II/VI; 21 chemotherapy, 52 chemoradiation and 4 radiotherapy; 52 adenocarcinomas, 18 squamous cell carcinomas and seven other types of histology. The aim of this study was to explore the expression of piR-796 piRNA, which was identified by small RNAseq, in resected nonsmall cell lung cancer (NSCLC) patients, and to analyze the correlation with the clinic-pathological features. Conclusions: Our data demonstrated that OTP expression was only rarely identified in non-pulmonary neuroendocrine tumors/carcinomas, which further validated the previous report of OTP to be a highly specific marker for diagnosing PCs. The diagnostic sensitivity for PCs in this study appears to be lower than the previous report, which is probably due to the small number of cases included. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104466/ doi: 10.1038/s41374-020-0400-0 id: cord-007563-33jxxp1b author: nan title: Full Issue PDF date: 2018-06-25 words: 8282.0 sentences: 475.0 pages: flesch: 46.0 cache: ./cache/cord-007563-33jxxp1b.txt txt: ./txt/cord-007563-33jxxp1b.txt summary: In the present study, we investigated titin-isoform expression, total-titin and site-specific N2Bus/PEVK phosphorylation, and the degree of fibrosis in endomyocardial biopsy samples from AS patients compared with nonfailing donor heart samples. In our patient group, we found a significant shift toward the more compliant N2BA titin isoform versus nonfailing donor heart samples ( Figure 2) . This GCH1-GFRP complex is operative in humans because oral challenge with L-phe leads to a 3-fold rise in plasma biopterin levels (a correlate of BH 4 )-an effect that is attenuated in patients with a loss-of-function GCH1 mutation (23 To support this hypothesis, it is known the GCH1-GFRP axis regulates BH 4 and NO in endothelial cells (25) . Some studies report that elevations in circulating biomarkers of oxidative stress (myeloperoxidase) precede clinically significant systolic dysfunction in anthracycline-treated patients (8, 15 CT images were used to localize the heart and confirm the epicardial surfaces for VOI edge placement. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119135/ doi: 10.1016/s2452-302x(18)30124-4 id: cord-007890-bie1veti author: nan title: ECC-4 Abstracts date: 2002-04-16 words: 85992.0 sentences: 5665.0 pages: flesch: 50.0 cache: ./cache/cord-007890-bie1veti.txt txt: ./txt/cord-007890-bie1veti.txt summary: Effects of Interferon alpha plus ribavirine therapy on frequencies of HCV, HIV and CMV specific CD4-T-cell responses in peripheral blood of HIV/HCV coinfected patients after 6 months of treatment SoA9.5 Methods: Two groups of patients with chronic HCV infection were studied: 26 HIV coinfected progressors with antiretroviral therapy and 13 HIV-negative controls. In order to assess the local temporal trend of antibiotic sensitivity of the most common urinary tract bacterial pathogen, all urine-cultured Escherichia coli isolates were reviewed as to susceptibility profile, and specimen source (community-versus hospital-acquired infection). Methods: A total of 87 penicillin resistant clinical strains isolated from patients at Hacettepe Children''s Hospital, Ankara, Turkey between 1999 and 2001 were tested for their in vitro susceptibility to various antibiotics that are commonly used in the treatment of respiratory tract infections. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126403/ doi: 10.1016/s0924-8579(02)00033-x id: cord-008695-y7il3hyb author: nan title: Pandemic Flu: Clinical management of patients with an influenza-like illness during an influenza pandemic date: 2007-01-25 words: 25924.0 sentences: 1616.0 pages: flesch: 46.0 cache: ./cache/cord-008695-y7il3hyb.txt txt: ./txt/cord-008695-y7il3hyb.txt summary: Children may be considered at increased risk of complications if they have cough and fever (or influenza-like illness) and temperature >38.5ºC, plus either chronic co-morbid disease or one of following features: breathing difficulties severe earache vomiting >24 hours drowsiness These patients should be offered an antibiotic as well as oseltamivir (in those >1 year of age) and advice on antipyretics and fluids. Children may be considered at increased risk of complications if they have: Cough and fever (or influenza-like illness) and temperature >38.5ºC and either (i) chronic co-morbid disease (see Appendix 2) or (ii) one of the following features • Breathing difficulties • Severe earache • Vomiting > 24 hours • Drowsiness These patients should be offered an antibiotic as well as oseltamivir (in those over one year of age) and advice on antipyretics and fluids. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133687/ doi: 10.1016/s0163-4453(07)60001-2 id: cord-009567-osstpum6 author: nan title: Abstracts Oral date: 2008-04-23 words: 131214.0 sentences: 7728.0 pages: flesch: 53.0 cache: ./cache/cord-009567-osstpum6.txt txt: ./txt/cord-009567-osstpum6.txt summary: Introduction: Previously, it has been demonstrated that FOXP3, a gene required for the development and function of regulatory T cells, was highly expressed in the graft during cardiac rejection, suggesting infiltration of regulatory T cells in the transplanted organ during an allogeneic response. Efficacy and safety parameters assessed at follow-up included: acute rejection; patient and graft survival; renal function, vital signs, basic lab results and immunosuppressive regimen for the patients 10 years after completion of the original study. We analyzed, for the first time, the expression of TLR4 in PBMC from kidney recipients with contrasted situations: operational tolerance and chronic immune-mediated rejection (Banff 2005), compared to patients with normal histology and stable graft function, non transplant patients with renal failure and healthy volunteers. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159651/ doi: 10.1111/j.1600-6143.2008.02254.x id: cord-009571-mygj2nd4 author: nan title: Proceedings of the 42nd annual meeting of the american rheumatism association a section of the arthritis foundation june 1 & 2, 1978 new york city abstracts of papers presented date: 2005-11-23 words: 46150.0 sentences: 2284.0 pages: flesch: 49.0 cache: ./cache/cord-009571-mygj2nd4.txt txt: ./txt/cord-009571-mygj2nd4.txt summary: Levels of Ty cells as well as total T lymphocytes were measured in 19 patients with systemic lupus erythematosus (SLE), 11 with active and 8 with inactive disease, and in 47 normal subjects. The diagnosis of GC arthritis were studied for the presence of GC antigen (AG) and anti-in all seven patients was made by typical clinical presentation, body (AB) in serum and synovial fluid by counter-positive local culture for Ngonorrhoeae (NG) , and response to treatment. A retrospective study was instituted on 10 patients in the UCLA lupus nephritis clinic in an attempt to determine the ability of three serologic indicators-specifically immune complexes (IC), anti-DNA antibodies (DNA-ab), and C3-to predict the activity of SLE renal disease as indicated by changes in 24 hour proteinuria, serum creatinine, and creatinine clearance. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159665/ doi: 10.1002/art.1780210508 id: cord-009664-kb9fnbgy author: nan title: Oral presentations date: 2014-12-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162236/ doi: 10.1111/j.1469-0691.2009.02857.x id: cord-009713-sxd4t2tz author: nan title: Poster Presentations date: 2020-01-10 words: 43950.0 sentences: 2945.0 pages: flesch: 52.0 cache: ./cache/cord-009713-sxd4t2tz.txt txt: ./txt/cord-009713-sxd4t2tz.txt summary: Poster No. 010 Seizure, developmental and cognitive outcomes in children post hemispherotomy TT TAY 1 , DR REED 2 , VJ JOSAN 3 , SR RUST 4 , JT TAN 5 1 University of Manchester, Manchester, UK; 2 Neuropsychology Team, Paediatric Psychosocial Service, Royal Manchester Children''s Hospital, Manchester, UK; 3 Neurosurgery, Salford Royal NHS Foundation, Manchester, UK; 4 Paediatric Neuropsychology, Royal Manchester Children''s Hospital, Manchester, UK; 5 Paediatric Neurology, Royal Manchester Children''s Hospital, Manchester, UK Introduction: Patients with focal refractory epilepsy secondary to structural hemispheric changes have been shown in retrospective studies to have significantly improved seizure outcomes following hemispheric disconnection. In a univariate analysis of 682 cases with ≥12 months follow-up data, poor final outcome (defined as modified Rankin Scale [mRS] score 3-6) occurred in 30% and was associated with very young or elderly age at onset, movement disorder, decreased consciousness, autonomic dysfunction, mechanical ventilation, higher mRS score in the acute phase, longer hospital stay, extreme delta brush on EEG, abnormal MRI, CSF pleocytosis and elevated CSF protein (all p<0.05). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163607/ doi: 10.1111/dmcn.14411 id: cord-009997-oecpqf1j author: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 words: 182060.0 sentences: 10342.0 pages: flesch: 48.0 cache: ./cache/cord-009997-oecpqf1j.txt txt: ./txt/cord-009997-oecpqf1j.txt summary: Completed cranial radiation and proceeded to allogeneic stem cell transplant with unrelated cord marrow donor and is disease free at approximately day +200.Case 2: 5 year-old female diagnosed with FLT3 and MLL negative AML and completed treatment per COG AAML1031 study on the low risk arm without Bortezomib. Design/Method: This study was a retrospective chart review that included patients 3 to 23 years old with sickle cell disease type SS and S 0 followed at St. Christopher''s Hospital for Children. Background: Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can reduce complications, and improve survival in sickle cell disease (SCD), but are associated with a significant decisional dilemma because of the inherent risk-benefit tradeoffs, and the lack of comparative studies. Brown University -Hasbro Children''s Hospital, Providence, Rhode Island, United States Background: Despite clinical advances in the treatment of sickle cell disease (SCD) in pediatric and young adult patients, pain remains a significant source of disease-related morbidity. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167873/ doi: 10.1002/pbc.27057 id: cord-010027-r0tl01kq author: nan title: Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland date: 2015-09-15 words: 36299.0 sentences: 2004.0 pages: flesch: 47.0 cache: ./cache/cord-010027-r0tl01kq.txt txt: ./txt/cord-010027-r0tl01kq.txt summary: Further profiling of other T cell populations may help to further understand this expression which may act as a biomarker or provide a therapeutic target Biomarkers that are able to distinguish stage II and III colon cancer patients at high risk of developing disease recurrence, who may benefit from adjuvant chemotherapy, are still lacking. *AM supported by the NIHR and the Academy of Medical Sciences ABSTRACTS S·17 Assessment of HER2 Status on Needle Core Biopsy of Breast Cancer: Impact of Histopathological Concordance P M Pigera; AHS Lee; IO Ellis; EA Rakha; Z Hodi Nottingham City Hospital, Nottingham, UK One of the key recommendations introduced in the ASCO/CAP update guideline recommendation on HER2 testing is the novel concept of "histopathological concordance." It is proposed that certain tumour morphological features such as histologic type and grade should trigger repeating a molecular test in cases of "discordance". abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168113/ doi: 10.1002/path.4631 id: cord-010075-72jodunj author: nan title: Paediatric SIG: Poster Session date: 2011-03-21 words: 32008.0 sentences: 1913.0 pages: flesch: 56.0 cache: ./cache/cord-010075-72jodunj.txt txt: ./txt/cord-010075-72jodunj.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169206/ doi: 10.1111/j.1440-1843.2011.01937_12.x id: cord-010078-8lkkez3n author: nan title: Invited Speakers date: 2010-11-24 words: 21351.0 sentences: 1012.0 pages: flesch: 43.0 cache: ./cache/cord-010078-8lkkez3n.txt txt: ./txt/cord-010078-8lkkez3n.txt summary: Both modes of imaging discriminate early malignant lesions from non-specifi c infl ammation, aid in selecting appropriate sites for biopsy and better delineate tumor margins for more precise staging, but are of little value at present in clinical practice since most patients with malignant pleural effusions have extensive pleural involvement that is easy to diagnose with white light pleuroscopy For pleuroscopic guided pleural biopsies, specimens obtained with the rigid forceps are larger than those with the fl ex-rigid pleuroscope since they are limited by size of the fl exible forceps, which in turn depends on the diameter of the working channel. In the United Kingdom, a thrombosis group has been formed to promote awareness among parliamentarians about the risk and management of VTE; to increase knowledge of its causes, effects, and treatments; and to monitor the implementation of government initiatives and other researches being and this program has corrected the wrong perception that PTE is a rare disease in China Pulmonary hypertension (PH) is a common complication of chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) or interstitial lung diseases (ILD). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169233/ doi: 10.1111/j.1440-1843.2010.01863.x id: cord-010088-s9tfvtao author: nan title: Oral Abstracts date: 2013-11-01 words: 43522.0 sentences: 2257.0 pages: flesch: 49.0 cache: ./cache/cord-010088-s9tfvtao.txt txt: ./txt/cord-010088-s9tfvtao.txt summary: These include ''incorrect blood component transfused'' events, where the blood component was intended for another recipient (frequently due to errors in patient identification at the time of collection of the pre-transfusion sample, or at the time of bedside administration), or did not meet the patient''s special needs (such as a patient with a red cell antibody who did not receive the required antigen-negative unit). Methods: Eligibility criteria for inclusion in the study included the following: transfusion of Rh D positive platelets, no anti D detectable before transfusion, no previous exposure to Rh D positive blood components, and results of follow-up testing of anti-D in patients serum available. In addition, the allelic frequency of Hpdel was calculated to be 0.015 by a genetic study of a limited number of the Japanese individuals, suggesting that Hp deficiency might distribute among the Japanese population as a phenotype of serum Hp. Aims: In this report, we present the results obtained from a hemovigilance survey carried out between 1998 and 2012, in which Hp deficiency was identified among Japanese patients who had experienced nonhemolytic TRs (NHTRs), and those obtained from a screening of Hp-deficient Japanese healthy blood donors. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169312/ doi: 10.1111/vox.12100_1 id: cord-010092-uftc8inx author: nan title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 words: 233304.0 sentences: 13171.0 pages: flesch: 54.0 cache: ./cache/cord-010092-uftc8inx.txt txt: ./txt/cord-010092-uftc8inx.txt summary: Prospective testing of blood donations in endemic areas of the U.S. revealed 0.38% of donors were positive for Babesia DNA or antibodies (Moritz, NEJM, 2016) Aims: -To report results of ongoing Babesia clinical trial -To explain significance of Babesia as a TT infection Methods: In cobas â Babesia for use on the cobas â 6800/8800 Systems, is a qualitative polymerase chain reaction nucleic acid amplification test, developed to detect in whole blood (WB) donor samples the 4 Babesia species that cause human disease: B. In sensitivity analyses, there were two discrepant results for HIV testing, three for HCV, and five for anti-HBc. Summary/Conclusions: Elecsys â infectious disease parameters on the cobas e 801 analyser demonstrate high specificity/sensitivity for screening first-time blood donor samples, with similar clinical performance to other commercially available assays. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169345/ doi: 10.1111/vox.12792 id: cord-010119-t1x9gknd author: nan title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 words: 230193.0 sentences: 13234.0 pages: flesch: 55.0 cache: ./cache/cord-010119-t1x9gknd.txt txt: ./txt/cord-010119-t1x9gknd.txt summary: Conclusion: The wide distribution in the concentration of bioactive lipids among 405 stored RBC units suggests that lipid degradation is highly donor-Background/Case Studies: To ensure availability of biological products to hospitals, blood banks have developed and validated multiple storage conditions for each of their products to maximize shelf life and quality. 1 The Department of Blood Transfusion, The PLA General Hospital, 2 The Department of Blood Transfusion, Air Force General Hospital, PLA Background/Case Studies: Recently, multi researches have reported that longer term-stored red blood cells(RBCs) units were associated with increased risks of clinically adverse events, especially in critically ill patients. Weak D types 1, 2 and 3 express all the major RhD epitopes and these patients can be managed as RhD-positive, which may lead to a reduction in unnecessary Rh immunoglobulin (RhIG) administration and conservation of RhD-negative RBCs. Study Design/Method: RHD genotyping was performed on all patient samples with weaker than expected or discrepant RhD typing results, utilizing a commercially available genotyping kit manufactured by Immucor (RHD BeadChip). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169716/ doi: 10.1111/trf.14286 id: cord-010980-sizuef1v author: nan title: ECTES Abstracts 2020 date: 2020-05-11 words: 132644.0 sentences: 8727.0 pages: flesch: 53.0 cache: ./cache/cord-010980-sizuef1v.txt txt: ./txt/cord-010980-sizuef1v.txt summary: We hypothesized that presentation to a PTC would yield increased mortality when subspecialty intervention was required and that this would be most pronounced at night when in-house attending coverage is absent at all state PTCs. Materials and methods: A review of the Pennsylvania Trauma Outcome Study (PTOS) database was performed to capture patients aged 12-18 who underwent any non-orthopedic trauma surgery. Traumatic subaxial cervical fractures: functional prognostic factors and survival analysis Introduction: The main goal of this study is to identify the risk factors for poor functional outcomes and to analyze the overall survival (OS) and complications rate in patients with traumatic cervical spinal cord injury (SCI) and subaxial cervical fracture (SACF) treated with open surgical fixation. After applying a multiple imputation on all the study variables, a logistic regression generalized estimating equation after adjustment for age, sex, mechanism of trauma, and the injury severity score as covariates and hospitals as a cluster assessed an association between quartile of patient volume in intensive care unit and hospital mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223217/ doi: 10.1007/s00068-020-01343-y id: cord-011062-ukz4hnmy author: nan title: Poster date: 2020-03-11 words: 88313.0 sentences: 5669.0 pages: flesch: 55.0 cache: ./cache/cord-011062-ukz4hnmy.txt txt: ./txt/cord-011062-ukz4hnmy.txt summary: Ming-Yueh Chou 1,3 , Ying-Hsin Hsu 1 , Yu-Chun Wang 1 , Chih-Kuang Liang 1,3 , Li-Ning Peng 2,4 , Liang-Kung Chen 2,4 , Yu-Te Lin 1 ((1) Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; (2) Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan; (3) Department of Geriatric Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan; (4) Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan) Background: Older people with frailty are at risk of adverse outcomes, such as falls, functional decline and mortality, and multi-domain intervention program may prevent those. Conclusion: Our study showed that a multicomponent exercise program is effective for posthospitalization patients because after 24-week intervention there were significant reductions in frailty and improving results in muscle strength and physical performance. Methods: Cross-sectional analysis of 757 communitydwelling older adults who completed multi-domain geriatric screen assessing for social vulnerability, mood, cognition, functional performance, nutrition, physical frailty (FRAIL) and sarcopenia (SARC-F). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223455/ doi: 10.14283/jfa.2020.9 id: cord-012518-ncrdwtdg author: nan title: Abstractband DOG 2020 date: 2020-08-24 words: 32627.0 sentences: 2475.0 pages: flesch: 59.0 cache: ./cache/cord-012518-ncrdwtdg.txt txt: ./txt/cord-012518-ncrdwtdg.txt summary: The improvement in tear film quality (measured by TBUT) was shown after application of trehalose/hyaluronate tear substitute for one month in both, glaucoma and control group patients with mild to moderate dry eye symptoms. Methods: For 351 eyes (275 patients) who underwent DMEK for Fuchs endothelial corneal dystrophy (FECD), donor ECD decrease as compared to preoperative donor ECD was evaluated up to four years after surgery. The present study included fundus images of 111 individuals with a mean refractive error of -9.3 ± 3.8 diopters (range:-20.8, +1.75) and an axial length of 26.8 ± 1.9 mm (range: 22.55, 30.88) Results: The disc-fovea distance increased significantly with longer axial length, with a relatively flat slope in the non-highly myopic eyes (Disc-Fovea-Distance = 24.3 × Axial Length (mm)+514) and a steeper slope in the highly myopic group (Disc-Fovea-Distance = 58.7 × Axial Length (mm)-460). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444158/ doi: 10.1007/s00347-020-01197-0 id: cord-012902-efprpk72 author: nan title: Abstracts from the 2020 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS) date: 2020-09-15 words: 10209.0 sentences: 701.0 pages: flesch: 55.0 cache: ./cache/cord-012902-efprpk72.txt txt: ./txt/cord-012902-efprpk72.txt summary: Methods: An iontophoretic pilocarpine-induced sweat sample, measures of TEWL (Tewameter ® , COURAGE +KHAZAKA electronic GmbH, Köln, Germany) and a skin punch biopsy were collected from adult, non-pregnant hypertensive patients at the Glasgow Blood Pressure Clinic (n = 90; age: 56 ± 16, range 21-86 years; females = 48.9%; BMI: median = 29.8, interquartile range 26.9-35.2 kg/m²). Results: Subjects with high NM (n = 30, 15 men) had greater body mass index than those with low NM (n = 30, 17 men): (mean ± SD) 31 ± 7 vs 27 ± 4 kg/m 2 (p < 0.05), but the two groups were similar with respect to age and brachial blood pressure (BP). This study investigates the feasibility of CPET for safe and effective cardiovascular exercise prescription in hypertensive patients Methods: 14 subjects (10 Male, 4 Female; aged 61.8 ± 10.8 years) with hypertension and undergoing medical therapy were recruited to the study. This study aims to investigate the patient factors associated with the prescribing of blood pressure lowering medications after any index stroke in Scotland. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491598/ doi: 10.1038/s41371-020-00410-6 id: cord-014670-e31g8lns author: nan title: Poster Sessions 313-503 date: 2004-10-05 words: 28575.0 sentences: 1706.0 pages: flesch: 55.0 cache: ./cache/cord-014670-e31g8lns.txt txt: ./txt/cord-014670-e31g8lns.txt summary: Over a 12-month period patients who needed reintubation after successful trial of weaning and planned extubation, in a polyvalent intensive care unit (ICU) were identified.Data including clinical features (age, sex, SAPS II on admission, Glasgow Coma Score (GCS) on day of extubation, type of patient, length of intubation and mechanical ventilation (MV) before extubation, length of ICU stay (LOS), ICU and hospital mortality) were collected.Moreover we considered two parameters that asses airway patency and protection like predictors of EF:cough strength and suctioning frequency after extubation.Cough strength on command was measured with a semiobjective scale of 0 to 5 (0= weak cough, 5= strong cough). (3/23)(13.2%), pulmonary embolism(1/23)(4.3%)and severe sepsis(1/23)(4.3%).Seven of patients who received reintubation a cause of defective airway manage needed at least one suctioning every two hours; moreover the same patients and other three with alteration in neurological function had weak cough (grade 0 to 2).The LOS of EF patients was 23±24.3 days, their ICU and hospital mortality were 39.1% and 47.8%, respectively, both higher when compared with not reintubated patients.Results of logistic regression showed that SAPS II is the only independent risk-factor of reintubation (odds ratio 1.056, sig. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079826/ doi: 10.1007/s00134-004-2406-2 id: cord-014687-0am4l5ms author: nan title: SPR 2012 date: 2012-03-29 words: 98592.0 sentences: 5600.0 pages: flesch: 43.0 cache: ./cache/cord-014687-0am4l5ms.txt txt: ./txt/cord-014687-0am4l5ms.txt summary: This presentation will focus on recent developments that have lead to a better understanding of the embryopathogenesis for fibropolycystic liver diseases (including choledochal cysts and Caroli disease), histopathological findings that have led to new classification systems for of pediatric vascular anomalies, technological advances and contrast agents in magnetic resonance imaging that are useful to characterize and limit the differential diagnosis of hepatic masses. Disclosure: Dr. Annapragada has indicated that he is a stock holder and consultant for Marval Biosciences Inc. Paper #: PA-067 Cardiovascular Image Quality Using a Nanoparticle CT Contrast Agent: Preliminary Studies in a Pig Model Rajesh Krishnamurthy, Radiology, Texas Children''s Hospital, rxkrishn@texaschildrens.org; Ketan Ghaghada, Prakash Masand, Abhay Divekar, Eric Hoffman, Ananth Annapragada Purpose or Case Report: Image quality in a separate study using a long circulating, liposomal-based nanoscale blood pool iodinated contrast agent (NCTX) suggests clinical utility in pediatrics, potentially reducing difficulties in contrast-CT of children with congenital heart disease (CHD) including the size of intravenous cannula, need for accurate timing, inability to simultaneously opacify multiple targets of interest (requiring repeated contrast administration and/or repeated imaging). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080092/ doi: 10.1007/s00247-012-2356-8 id: cord-014712-5u4e00q6 author: nan title: Selected Abstracts from the 100th J Project Meeting, Antalya, Turkey, March 12-14, 2014 date: 2014-08-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086544/ doi: 10.1007/s10875-014-0065-9 id: cord-014794-yppi30a0 author: nan title: 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date: 2003-07-31 words: 158059.0 sentences: 9041.0 pages: flesch: 44.0 cache: ./cache/cord-014794-yppi30a0.txt txt: ./txt/cord-014794-yppi30a0.txt summary: These parts were in a high percentage associated with fibrosis and lymphocyte rich areas and showed a higher mitotic activity than usual PTCs. Discussion The differences in the occurrence of TCV and TCmorphology between the presented series and previously reported cases might result from until now not clearly defined tall cell morphology as well as from similarities to PTCs, such as the oxyphilic variant, which is extremely rare in our series, and maybe also from often described squamous changes within PTCs. Due to these data it is not clear which tumor parts have relevance for prognosis and which tumors should be treated more aggressively than others. The aims of this study were to characterize the group of patients with BSOT and evaluate the significance of various molecular markers expression versus serous papillary ovarian carcinomas (SPOC) Material and methods We analyzed a total of 102 cases including: 64 cystadenoma, 10 borderline and 28 cystadenocarcinoma. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087991/ doi: 10.1007/s00428-003-0864-5 id: cord-014965-efmozngq author: nan title: Infectious diseases other than CMV (1st Section) date: 2001-06-11 words: 8007.0 sentences: 453.0 pages: flesch: 51.0 cache: ./cache/cord-014965-efmozngq.txt txt: ./txt/cord-014965-efmozngq.txt summary: To evaluate the influence of the helicobacter pylori (h.p.) infection on gastrointestinal complications after high-dose chemotherapy and stem cell transplantation (STX) we tested 114 patients (54 female, 60 male) by the 13C-urea breath test prior to initiation of conditioning therapy. 26 immunocompromised patients (15-70 y, median 44; 17 leukemia, 7 myeloma, 2 lymphoma) received 32 courses of ABLC at the median daily dose of 2 mg/kg rounded off to the nearest vial size (range, 1.3-2.7 mg/kg) after autologous (n=7) or allogeneic (n=8) stem cell transplantation or chemotherapy (n=17). Seven of the 12 allogeneic transplanted patients with at least one positive PCR-result had a VZV-disease. All (n=2) of the autologous transplanted patients with a positive PCR-result developed a VZV-disease. Background: Severe acute graft-versus-host-disease (aGvHD) of the gut is still a major complication after allogeneic stem-cell transplantation (SCT) as response rates to treatment (tx) of intestinal GvHD (iGvHD) are lower than those observed for GvHD of the skin. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091871/ doi: 10.1038/sj.bmt.1702942 id: cord-014976-546zaoxn author: nan title: Publication only date: 2006-03-08 words: 51926.0 sentences: 2983.0 pages: flesch: 53.0 cache: ./cache/cord-014976-546zaoxn.txt txt: ./txt/cord-014976-546zaoxn.txt summary: In order to evaluate if malignant and non malignant hematological diseases quantitatively and qualitatively affect BM derived MSCs, bone marrow from children with acute lymphoblastic leukemia (ALL diagnosis n=9, different phases of treatment n=29, end of therapy n=10), idiopathic thrombocytopenic purpura (n=16), autoimmune neutropenia (n=12) and control patients (solid tumors without BM involvement, n=30) was harvested and the mononuclear cell (MNC) fraction isolated. Case: In our hospital a total of 3 patients with relapsed Hodgkin''s disease underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) from an HLA-identical sibling. We report a case of a young male patient of 19 years old with aggressive MS who was treated with a high-dose immunosuppressive regimen (HDIS) using myeloablation followed by autologous blood stem cell transplantation (ASCT) that has induced a dramatic and long-lasting remission of the disease. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092326/ doi: 10.1038/sj.bmt.1705327 id: cord-014987-nycbjqn6 author: nan title: OP 0364-0412 date: 2006-08-24 words: 9795.0 sentences: 580.0 pages: flesch: 55.0 cache: ./cache/cord-014987-nycbjqn6.txt txt: ./txt/cord-014987-nycbjqn6.txt summary: In the "Prevalence of severe sepsis and septic shock in Intensive Care Units in Germany" study, a prospective observational cross-sectional study, data from 454 ICUs in 310 randomly selected hospitals in Germany were collected by local one-day visits of trained physicians from SepNet''s 17 regional study centers. Despite the higher APACHE II score in both groups (median score 21 or 18.5, respectively compared with 16.5 in the enteral group, p<0.01) our results indicate that parenteral nutrition has an important attributable effect on mortality in septic patients. In this follow up study, we document the impact of intensive insulin therapy on long term mortality and objective and subjective well-being of high risk cardiac surgical patients. 4 years after ICU-admission, we assessed long term outcome of the subgroup of cardiac surgical patients (N=970) included in the original insulin trial (1) . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094891/ doi: 10.1007/s00134-006-0318-z id: cord-014996-p6q0f37c author: nan title: Posters_Monday_12 October 2009 date: 2009-08-06 words: 85190.0 sentences: 5288.0 pages: flesch: 54.0 cache: ./cache/cord-014996-p6q0f37c.txt txt: ./txt/cord-014996-p6q0f37c.txt summary: Data recorded on admission were the patient demographics with, acute physiology and chronic health evaluation II score (APACHE II), and type of admission; during intensive care stay, sepsis-related organ failure assessment score (SOFA) and clinical concomitant factors and conditions. For each severe septic patient the following data was registered: time delay, APACHE II and SOFA scores at ICU admission, diagnosis, the rate of compliance with the resucitation and management bundles, microbiological data, evolution of levels of serum lactate, empiric antibiotic therapy, length of stay and mortality in ICU. Sepsis and septic shock remain the most important causes of acute kidney injury (AKI) in critically ill patients and account for more than 50% of cases of acute renal failure (ARF) in intensive care units (ICU). There were no significant differences between the demographic data (sex, age) or the data on admission to intensive care (APACHE II score, ratio of medical to surgical patients) and duration of mechanical ventilation between the two groups. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094934/ doi: 10.1007/s00134-009-1593-2 id: cord-015021-pol2qm74 author: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162327.0 sentences: 9379.0 pages: flesch: 50.0 cache: ./cache/cord-015021-pol2qm74.txt txt: ./txt/cord-015021-pol2qm74.txt summary: It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095072/ doi: 10.1007/bf02258437 id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84393.0 sentences: 5234.0 pages: flesch: 52.0 cache: ./cache/cord-015024-2xzc0uc5.txt txt: ./txt/cord-015024-2xzc0uc5.txt summary: We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095088/ doi: 10.1007/s00134-010-2001-7 id: cord-015082-l629n8is author: nan title: Poster Sessions 323-461 date: 2002-08-29 words: 26569.0 sentences: 1648.0 pages: flesch: 52.0 cache: ./cache/cord-015082-l629n8is.txt txt: ./txt/cord-015082-l629n8is.txt summary: 14 patients awaiting urgent cardiac surgical re-vascularisation were studied with measurement of: spirometry; percentage increase in transfer factor from sitting to lying position (TF) as an indicator of micro-vascular lung disease; overnight oximetry on air; and 24hour holter monitoring Patients, who were reintubated on decreased indices of arterial oxygenation under MOSF progressing died in 100% cases ( NIMV is effective method in complex therapy of ARF, developing in postoperative period after cardiac surgery, that leads to significant improvement of lungs biomechanics and gases change function. In a prospective observational study we performed bedside ptO2 measurements in 8 patients with sepsis/septic shock to gain insight in ptO2 values and their dynamic changes related to the course of the illness, as well as investigating the practical applicability of tissue oxygen measurement in the ICU setting. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095316/ doi: 10.1007/s00134-002-1455-7 id: cord-015090-n6f4xupw author: nan title: PS 339-563 date: 2005-09-10 words: 26280.0 sentences: 1560.0 pages: flesch: 53.0 cache: ./cache/cord-015090-n6f4xupw.txt txt: ./txt/cord-015090-n6f4xupw.txt summary: We designed this study to examine the effects of fiberoptic bronchoscopy (FOB) with and without BAL on body temperature, systemic arterial pressure, heart rate and supportive therapies requirements in mechanically ventilated patients. Clinical characteristics (Glasgow scale, heart rate, systolic blood pressure), cardiac enzymes (troponin I, total serum creatine kinase and myocardial isoenzyme, myoglobin), ECG changes (ST-T changes, prolonged QT and corrected QT intervals), echocardiographic assessment of cardiac function (left ventricular ejection fraction, hypokinesia) were studied on the day of the admission. It is a prospective study performed during 12 months of the patients with brain trauma admitted in a 24-beds medical-surgical ICU of a 650-beds university hospital. This prospective observational study included 200 adult patients admitted to a 31-bed university hospital medical-surgical ICU during a 3-month period. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095344/ doi: 10.1007/s00134-005-2780-4 id: cord-015126-cyhcbk1j author: nan title: PS 0036-0344 date: 2007-08-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095535/ doi: 10.1007/s00134-007-0820-y id: cord-015162-6be21d59 author: nan title: Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin date: 2016-05-04 words: 6831.0 sentences: 725.0 pages: flesch: 54.0 cache: ./cache/cord-015162-6be21d59.txt txt: ./txt/cord-015162-6be21d59.txt summary: Aim of the study: To investigate whether the use of Ticagrelor in comparison to other platelet-inhibitors is associated with a greater risk of bleeding or death in patients with acute myocardial infarction in the emergency room. Initiale Laborwerte: pH 7,2, pO 2 9,3 kPa (unter 3 l O 2 /min), pCO 2 5,8 kPa, BE -10, HCO 3 17; K+ 3,4; Na 143; Hb 6,8; Kreatinin 106; Harnstoff 3,5; Lactat 7,3; Glucose 9 (je mmol/l); Leukozyten: 12 (je Gpt/l); Methode: Therapie in den ersten 12 Stunden: Übernahme auf die Intensivstation, dort Intubation, rasch sich entwickelnder exzessiver Katecholaminbedarf mit Kreislaufstillstand und Reanimation. This difference does not lead to higher in-hospital mortality as compared to men in Hintergrund: Akute Herzinsuffizienzsyndrome (AHFS) sind die häufigste Ursache für Hospitalisierungen in Deutschland, verursachen enorme Kosten und zeigen eine hohe Mortalität. Ziel der Studie ist es den fungalen Biomarker 1,3-Beta-D-Glucan (BDG) hinsichtlich einer frühen Detektion einer IM und als Outcome-Parameter bei immunsupprimierten Intensivpatienten mit septischen Schock zu evaluieren. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096035/ doi: 10.1007/s00063-016-0166-8 id: cord-015306-us58wwmp author: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 words: 71194.0 sentences: 4580.0 pages: flesch: 53.0 cache: ./cache/cord-015306-us58wwmp.txt txt: ./txt/cord-015306-us58wwmp.txt summary: The incidence of renal involvement varies from 20 to 60% and there have been some reports showing that nephritis might be related to an older age at onset, persistent purpura (> 1 month), severe abdominal pain, and relapsing disease.Recently, several studies have shown that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, resulting in the formation of the circulating immune complexes and their mesangial deposition causing renal injury in HSP nephritis and serum galactose-deficient IgA1 levels were highly inherited in children with HSP nephritis.Regarding the treatment of HSP, one randomized double-blinded controlled study recently showed that patients with abdiminal pain or arthralgia may benefit from early treatment with prednisone, but the drug has not been proven to be capable of preventing the development of renal symptoms. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101731/ doi: 10.1007/s00467-013-2518-4 id: cord-015324-y44sfr0c author: nan title: Scientific Programme date: 2007-09-01 words: 197618.0 sentences: 12774.0 pages: flesch: 53.0 cache: ./cache/cord-015324-y44sfr0c.txt txt: ./txt/cord-015324-y44sfr0c.txt summary: In order to further validate this approach, we performed a prospective randomized open-label multicenter trial in 41 low-risk pediatric renal transplant recipients (12 f, 29 m; mean age 10.1 yrs; range, 3.4 to 17.8) on CsA (target trough level 100-200 ng/ml), MMF (1200 mg/m 2 per day) and methylprednisolone (3) (4) mg/m 2 per day), who were randomly assigned >1 year posttransplant to continue steroids or to withdraw over a period of 3 months. We evaluated MMF in 15 children with LN, 11 F/4 M, mean age: 12.4±3.9 yrs, proteinuria >3 g/day, decreased C3 and increased anti-dsDNA serum levels, normal renal function. Patients and methods: 91 children and adolescents (60 male, 31 female, mean age at transplantation 9.7±5.2 years) with stable renal function and observation period exceeding 6 months were included. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101932/ doi: 10.1007/s00467-007-0558-3 id: cord-015334-8p124rwp author: nan title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 words: 51143.0 sentences: 3291.0 pages: flesch: 51.0 cache: ./cache/cord-015334-8p124rwp.txt txt: ./txt/cord-015334-8p124rwp.txt summary: Based on the results of the pharmacoeconomic analysis, development of clinical pharmacy and CIVAS for some drugs will be discussed with the paediatric department Background and Objective: Studies show that up to 38% of patients starting treatment with antidepressants fill only a single prescription at the pharmacy, apparently not accepting treatment. Main Outcome Measures: Data collected were: nurses'' profile (age, length of service, competencies'' self-assessment), knowledge on drugs prescribed to their patients (usage, administration, side-effects, drug interactions…), use of existing tools (i.e. drugs database) and possible tools to be developed by the pharmacy ward to help them in their daily practice. The objectives were:(1)To identify the most relevant minor ailments, agreeing on the specific criteria for referral to the GP.(2)To select the non-prescription drugs, with evidence of safety and effectiveness, for the treatment of the identified minor ailments Design: Qualitative study with an expert panel which was made up of 2 primary care physician from SEMFYC and six community pharmacists (two members of SEFAC and four members of GIAF-UGR). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102062/ doi: 10.1007/s11096-008-9226-3 id: cord-015335-l0kjxhd1 author: nan title: Irish Society of Gastroenterology: Proceedings for summer meeting – 26th/27th May 1995 in Galway date: 1995 words: 8724.0 sentences: 508.0 pages: flesch: 52.0 cache: ./cache/cord-015335-l0kjxhd1.txt txt: ./txt/cord-015335-l0kjxhd1.txt summary: The results suggest that an aneuploid DNA pattern is a predictor of high risk potential for metastases to the liver and may be a useful tool in the "followup" of patients with gastric carcinoma in detecting those at high risk of developing metastases following surgical resection. A partially purified preparation of oesophageal tumour-derived inimune suppressor factor that has been shown to be free of all known cytokines was tested in dose-ranging studies on cell proliferation and apoptosis using lymphocytes from the mutant and control mice. Currie et al have demonstrated that arginase is cytotoxic to tumour cells by depletion of the essential amino acid L-arginine, therefore the aim of this study was to determine the role of this enzyme in colorectal tumour-derived MOs. Human peripheral blood monocytes (PBM) were isolated from aged-matched controls (CON) and from blood pre-operatively obtained from patients undergoing surgery for colorectal cancer. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102063/ doi: 10.1007/bf02967835 id: cord-015348-qt0worsl author: nan title: Abstract date: 2010-07-30 words: 74085.0 sentences: 4714.0 pages: flesch: 45.0 cache: ./cache/cord-015348-qt0worsl.txt txt: ./txt/cord-015348-qt0worsl.txt summary: However, the application of the compounds in clinical trials has revealed promising results only when predictive procedures have been available for determining which patients will benefit from targeting therapy, so-called eligibility or predictive tests, e.g. Her2 in breast cancer, KRAS and EGFR mutations in colorectal cancer and non-small cell lung cancer. Conclusion: We report on the development of a quantitative tissue-based immunohistochemical (IHC) methodology employing activation-specific antibodies against multiple components of the BCR signaling pathway that will assess the activity of the BCR pathway in formalin-fixed paraffinembedded primary DLBCLs. This approach will identify the subset of patient tumors that are actively signaling through the BCR pathway and, therefore, will predict therapeutic responsiveness to targeted inhibition of BCR signaling. Method: In our study, we investigate 120 cases diagnosed with invasive breast carcinoma in which we established microscopic characterization, immunohistochemical profiles (expression of proliferation markers, steroid receptors and Her2) and computer-assisted morphometric profiles by determining the mean values for nuclear area, cellular area and N/C ratio with Lucia Net Software. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102354/ doi: 10.1007/s00428-010-0947-z id: cord-015352-2d02eq3y author: nan title: ESPR 2017 date: 2017-04-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103096/ doi: 10.1007/s00247-017-3820-2 id: cord-015354-yknwveyz author: nan title: Abstracts_Poster presentations date: 2007-09-18 words: 221428.0 sentences: 13119.0 pages: flesch: 54.0 cache: ./cache/cord-015354-yknwveyz.txt txt: ./txt/cord-015354-yknwveyz.txt summary: Material and Methods: Fourteen individuals (mean age 47±19y range 21-75y; 4W, 10M; including 10 volunteers and 4 patients with angiographically proved CAD) underwent dynamic PET imaging studies (21 frames) at rest and during adenosine stress (0.14mg/kg/min for 6 min) after injection of 1100MBq of 82Rb (Discovery LS, GEMS). Methods:Twenty-nine patients (21 males,8 females;62±11 yrs) with recent AMI were studied.Within 6 days after AMI, the patients were performed Tl-201 R-RD perfusion SPECT using 4 mCi activity.CMR was carried out 5-20 minutes after 0,15 mmol/kg of iv.Gadobutrol injection.Myocardial perfusion and contrast enhancement was analyzed using a 17 segment model.Myocardial perfusion was scored in Tl-201 SPECT as follows:0=normal (70%-100% maximal myocardial activity(mma), 1= 69-50% mma, 2= 49-30% mma ,3=29-10% mma and 4=<10% mma ;Myocardial contrast enhancement on CMR images was graded as:0=no contrast enhancement, 1=hyperenhancement of 0-25% of the wall thickness(WT) 2=hyperenhancement of 26-50 % of the WT, 3=hyperenhancement of 51-75 % of WT and 4=hyperenhancement of 76-100 % of WT.In CMR the existence of microvascular obstruction(MO) was also evaluated.Total segment scores(TSS) in R,RD and CMR for each patient were calculated by summing of 17 segment score values. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103105/ doi: 10.1007/s00259-007-0544-9 id: cord-015359-gf32a6f1 author: nan title: B scientific sessions (SS) date: 2002 words: 159591.0 sentences: 9768.0 pages: flesch: 51.0 cache: ./cache/cord-015359-gf32a6f1.txt txt: ./txt/cord-015359-gf32a6f1.txt summary: Methods and materials: 73 consecutive patients, clinically considered to have stage 1B tumour (confined to the cervix), underwent MR imaging studies at 1 T, according to the following protocol: fast spin-echo (FSE) T2-weighted, gadoliniumenhanced SE Tl-weighted, and fat-suppressed gadolinium-enhanced SE Tlweighted sequences. Purpose: To describe the radiological (thin section CT) findings correlated to activity and remission in ANCA associated pulmonary-renal small vessel vasculitis (SVV) Material and methods: We used retrospective analysis of 37 CTs, 27 in disease activity (8 first manifestations, 19 relapses) 10 im remission of 17 patients with pulmorenal syndrome (9 Wegener, 4 microscopic polyangiitis-MPA, 3 Churg-Strauss-syndrome, 1 idiopathic crescentic glomerulonephritis following the Chapel Hill classification) 7 women, 10 men, median 65.5 years (34 -84). Varghese, P.R. Mueller; Boston, MA/US Purpose: We sought to determine the incidence of malignancy and to assess a possible role for image guided biopsy of this category of renal masses Materials & methods: Of the 397 renal biopsies performed at our institution between 1991 and 2000; a total of 28 patients with 28 category III lesions, were identified for analysis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103164/ doi: 10.1007/s00330-002-0002-9 id: cord-015365-iqdi99pd author: nan title: 25th Annual Meeting of the Austrian Society of Transplantation, Transfusion and Genetics Graz, October 19–21, 2011 date: 2011 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103185/ doi: 10.1007/s10353-011-0041-z id: cord-015368-a0qz4tb9 author: nan title: 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date: 2007 words: 86620.0 sentences: 6042.0 pages: flesch: 51.0 cache: ./cache/cord-015368-a0qz4tb9.txt txt: ./txt/cord-015368-a0qz4tb9.txt summary: Surgical treatment and evaluation, complications, short and long term patency of our patients were compared to interventional techniques and international literature. The aim of the study was to investigate: i) relevant and combined determinants of the development, management and outcome of a representative patient cohort (n ¼ 9.991) with acute appendicitis enrolled in a prospective unicenter study through a time period of 27 years (middle Europe), and ii) the frequency and impact of specific categories (e.g., characteristics of the medical history, clinical and intraoperative findings, complications), correlation and relative risk factors of the disease and its prognosis. From 01=1997 until 12=2006 198 TEM procedures were performed in 194 patients, 104 males, 90 females, mean age was 68.9 years (38-91), the median hospital stay was 8 days . No conversion to open technique had to be performed, no postoperative surgical complications were observed, one patient died 4 weeks postoperative due to liver failure following esophageal varices bleeding. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103188/ doi: 10.1007/s10353-007-0330-8 id: cord-015369-72cjogxz author: nan title: 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date: 2009 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103189/ doi: 10.1007/s10353-009-0461-1 id: cord-015370-4jfgsic7 author: nan title: 55th Annual Meeting of the Austrian Society of Surgery: Graz, June 25—27, 2014 date: 2014-06-03 words: 46551.0 sentences: 4856.0 pages: flesch: 48.0 cache: ./cache/cord-015370-4jfgsic7.txt txt: ./txt/cord-015370-4jfgsic7.txt summary: Obwohl die fehlerhafte Aufklärung durch Ärzte unter Juristen schon länger ein "Renner" ist, hat sich in der Praxis häufig noch nicht herumgesprochen, wie und vor allem wann der Patient vor einem chirurgischen Eingriff aufgeklärt werden muss. Objective: This study aimed to investigate the effect of single and combined baseline concentrations of b vitamins on postoperative survival of vascular surgery patients over a time of 8.5 years in a region without folate fortification. Laparoscopic resection of 2 gastric duplication cysts in a pediatric patient: report of a case Ergebnisse: Mit Ausnahme von 6 der Mädchen mit 32 funktionellen Zysten, die konservativ behandelt wurden, wurden alle anderen Tumoren nach Durchführung einer Schnellschnittuntersuchung reseziert, bei 2 Mädchen mit malignen Tumoren war nur ein Tumordebulking möglich. Methods: Twenty-two patients, who underwent endoscopic band removal between June 2002 and December 2013, were ret-und in manchen Fällen ist die Amputation der einzige Ausweg, wenn auch diese sorgfältig gegen Risiko und Nutzen einer komplexen Rekonstruktion abgewogen werden muss, um im Endeffekt dem Patienten ein paar Jahre mit hoher Lebensqualität zu ermöglichen. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103191/ doi: 10.1007/s10353-014-0261-0 id: cord-015372-76xvzvdg author: nan title: National scientific medical meeting 1996 abstracts date: 1996 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103226/ doi: 10.1007/bf02945204 id: cord-015389-vwgai4k9 author: nan title: Publication only date: 2009-03-25 words: 23868.0 sentences: 1465.0 pages: flesch: 57.0 cache: ./cache/cord-015389-vwgai4k9.txt txt: ./txt/cord-015389-vwgai4k9.txt summary: This study evaluates the safety of this approach, in terms of infusion-related toxicity and hematopoietic reconstitution, in 385 consecutive autologous transplantations performed from 4/97 to 9/08 in 348 patients (median age 46; underlying disease: lymphoma in 178, myeloma in 131, acute leukaemia in 17, breast cancer in 22). Patients and methods: Eight pts after allogeneic hematopoetic stem cell transplantation (HSCT) underwent MSCs infusions (median age of pts was 11 years, male/female: 6/2) between 2006 and 2009. Akiyama Tokyo Metropolitan Komagome Hospital (Tokyo, JP) Acute graft-versus-host disease (GVHD) is one of the major factors that have infl uence on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Material and methods: during a 8 years period we have performed 144 stem cells transplantation in 134 patients with different hematological malignancies(AML: 74; ALL: 6; CML: 7; CLL: 1, NHL: 13; Hodgkin Diseases: 16; Multiple myelomas: 24; Aplastic anaemia: 1;Myelofi brosis:1 Ewing Sarcoma: 1; Male:78 Female 66. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104434/ doi: 10.1038/bmt.2009.50 id: cord-015569-vy49r1zd author: nan title: Abstracts from the 45(th) Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7(th), 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University) date: 2012-05-17 words: 18852.0 sentences: 939.0 pages: flesch: 51.0 cache: ./cache/cord-015569-vy49r1zd.txt txt: ./txt/cord-015569-vy49r1zd.txt summary: In this study, in order to test whether the cadherins are required for formation of synapse between gustatory nerve fibers and taste receptor cells, we have investigated expression patterns of cadherin superfamily in the taste buds. Therefore, this study aimed to examine differences in immunoreactivities under various tissue-preparing conditions in rat vallate taste buds for some typical markers of gustatory cells as follows: gustducin, type III inositol triphosphate receptor (IP 3 R3), synaptobrevin-2 (VAMP2), protein gene product 9.5 (PGP9.5), and neural cell adhesion molecule (NCAM). Mainly developing artificial-lipids-based taste sensors with global selectivity, our research group have studied for realization of Ã�taste-odor fusion biosensor system,Ã� which estimates quality (deliciousness and safety) of foods or beverages using several sensor outputs through analysis and evaluation of subjective-objective relation. As a first step, we conducted a series of human sensory tests to investigate perceptual similarities between odorants, and then compared the results with activity patterns evoked on the glomerular layer of the olfactory bulb in rats. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109919/ doi: 10.1093/chemse/bjs052 id: cord-016757-3d320c0a author: nan title: Acute and chronic liver insufficiency date: 2008 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The term “liver insufficiency” denotes a break down in the functions of the liver. The syndrome of functional liver failure covers a wide spectrum of clinical, biochemical and neurophysiological changes. In principle, liver insufficiency can occur without previous liver damage as well as with already existing liver disease. It is characterized by a deterioration in the synthesizing, regulatory and detoxifying function of the liver. This final stage of liver disease terminates in hepatic coma. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121136/ doi: 10.1007/978-3-540-76839-5_20 id: cord-017184-1ewi3dka author: nan title: Primary Immunodeficiencies date: 2008 words: 44492.0 sentences: 2035.0 pages: flesch: 45.0 cache: ./cache/cord-017184-1ewi3dka.txt txt: ./txt/cord-017184-1ewi3dka.txt summary: In this disease, microorganism phagocytosis by polymorphonuclear (PMN) leukocytes appears annulled, and the patient is subject to severe infections supported by capsular bacteria: the deficiency, described in association with severe and recurrent infantile infections [175, 485, 487] , depends on the lack of mannose-binding lectin (MBL) [487] , its Primary Immunodeficiencies a possible atopy dependence on IgA underproduction rather than on IgE hyperproduction ( Fig. 4.1 ): in children with levels of IgA at the minimum normal level, and followed from birth until the age of 18-23 months, a greater severity of atopic manifestations and an increased cumulative incidence of asthma, AD and otitis media with effusion (OME) were observed compared to controls. abstract: Primary immunodeficiencies (PIDs), once considered to be very rare, are now increasingly recognized because of growing knowledge in the immunological field and the availability of more sophisticated diagnostic techniques and therapeutic modalities [161]. However in a database of >120,000 inpatients of a general hospital for conditions suggestive of ID 59 patients were tested, and an undiagnosed PID was found in 17 (29%) of the subjects tested [107]. The publication of the first case of agammaglobulinemia by Bruton in 1952 [60] demonstrated that the PID diagnosis is first done in the laboratory. However, PIDs require specialized immunological centers for diagnosis and management [33]. A large body of epidemiological evidence supports the hypothesis of the existence of a close etiopathogenetic relation between PID and atopy [73]. In particular, an elevated frequency of asthma, food allergy (FA), atopic dermatitis and enteric pathologies can be found in various PIDs. In addition we will discuss another subject that is certainly of interest: the pseudo-immunodepressed child with recurrent respiratory infections (RRIs), an event that often requires medical intervention and that very often leads to the suspicion that it involves antibody deficiencies [149]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121684/ doi: 10.1007/978-3-540-33395-1_22 id: cord-019347-tj3ye1mx author: nan title: ABSTRACT BOOK date: 2010-02-19 words: 107926.0 sentences: 6940.0 pages: flesch: 53.0 cache: ./cache/cord-019347-tj3ye1mx.txt txt: ./txt/cord-019347-tj3ye1mx.txt summary: Method:Case Report:A 15y/o w/f athlete presented with a two month history of recurrent hives and angioedema which she associated with ingestion of Halloween candy .One week before evaluation she had hives with Coconut as well.Her history was othewise unremarkable except for recurrent UTI''S, annual sinusitis, pneumonia in 1998 as well as migraines.She denied sexual activity.Her physical exam was normal.Results:An evaluation for autoimmune disease revealed normal ESR, ANA, DSDNA, mono and hepatitis serology as well as lyme titers however her CH50 was low17u/ml(normal 26-58U/ml)and evaluation of complement revealed c4 14mg/dl(normal 16-47mg//dl)and c2 <1.3mg/dl(normal 1.6-3.5mg/dl)with normal c3, c5-c9.Her father had nor-malc4 but c2 was 1.4mg/dl (normal 1.6-3.5mg/dl)Her sister had c2 of 1.5mg/dl and normal c4 and her mother had normal c2 and c4.Her workup included positive prick skin test to ragweed, ash and grass and she was started on Rhinocort and Clarinex seasonally.She has been followed for one year with resolution of hives and is asymptomatic.Her diagnosis had been confirmed by a pediatric rheumatologist.Conclusion;We present an atypical case of C2 complement deficiency in an currently asymptomatic individual. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129269/ doi: 10.1016/s1081-1206(10)61294-x id: cord-019490-m1cuuehi author: nan title: Abstracts cont. date: 2015-12-28 words: 93588.0 sentences: 5683.0 pages: flesch: 50.0 cache: ./cache/cord-019490-m1cuuehi.txt txt: ./txt/cord-019490-m1cuuehi.txt summary: Tigecycline Evaluation Surveillance Trial (TEST) -Global in vitro antibacterial activity against selected species of glucose non-fermenting organisms Objective: Despite the introduction of new antimicrobials to treat resistant gram-positive bacteria, Staphylococcus aureus continues to be a therapeutic challenge for the clinician. Two prospective studies from our centre identified common causes of CAP in India to be Mycoplasma pneumoniae [MP] and Legionella pneumophila [LP] by serology in 11% each, and SPN in 10% by culture of respiratory secretions/blood/ Conclusion: Although SPN is the most common isolate, the rising numbers of gram negative organisms (38%) and atypical pathogens associated with increasing mortality stress the need for review of initial antibiotic choice for adults with higher PORT classes. Conclusion: The spectrum of isolates among our patients were shifting towards gram positive bacteria with high resistance to different groups of antimicrobial agents limiting few choices for alternative therapies for infection control. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129916/ doi: 10.1111/j.1469-0691.2005.clm_1134_02.x id: cord-019964-9leljj8j author: nan title: Recent research in infectious disease date: 2005-01-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133612/ doi: 10.1016/j.jinf.2004.11.005 id: cord-020342-u8jzmloq author: nan title: Index to volume 42, January–June 2003() date: 2003-11-20 words: 3793.0 sentences: 373.0 pages: flesch: 58.0 cache: ./cache/cord-020342-u8jzmloq.txt txt: ./txt/cord-020342-u8jzmloq.txt summary: Impact on hospital resources of patients with severe congestive heart failure who use the emergency department for primary care Antiemetic therapy in US emergency departments: findings from the year 2000 National Hospital Ambulatory Medical Care Survey database Elevated blood lead levels associated with the consumption of moonshine among emergency department patients in Bioimpedance monitoring changes therapy in dyspneic emergency department patients: the IMPACT trial Use of ischemia-modified albumin in emergency department risk stratification of chest pain is both clinically effective and cost-effective Mathematical model of the hypoventilating patient: implications for the emergency department Clinical characteristics of emergency department patients who rule in versus rule out for pulmonary embolism by computed tomography chest angiography and indirect lower extremity computed tomography venography Role of air bags in preventing motor vehicle crash-related serious injuries: perceptions among emergency department patients Eight-hour emergency department observation for blunt abdominal trauma patients with initially negative diagnostic studies abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135002/ doi: 10.1016/s0196-0644(03)01106-5 id: cord-021087-n4epxwn9 author: nan title: ECR – Final Programme: Scientific and Educational Exhibits date: 2004 words: 154170.0 sentences: 9372.0 pages: flesch: 48.0 cache: ./cache/cord-021087-n4epxwn9.txt txt: ./txt/cord-021087-n4epxwn9.txt summary: Conclusions: MRI is useful to identify tumor response to Imatinib Mesylate in advanced GIST as from the early months of therapy with the following indicators of treatment activity: A) Size of lesions; B) signal intensity; C) vascularization; D) amount of degenerative tissue or necrosis; E) presence of peritoneal fluid. Materials and Methods: 34 patients (13 female, 21 male) from two centres with proven myocardial infarction by ECG, clinical and echo criteria underwent stress/ rest Tc99 sestamibi Gated SPECT scanning with a dual headed gamma camera and late contract enhanced MRI on identical 1.5 Tesla scanners in each centre using a protocol which imaged 15 minutes after injection of 0.1 mmol/kg IV gadolinium. These preliminary results illustrate the ability of MRI to assess the integrity of the TFCC and suggests its use as the first imaging method following plain radiography in the evaluation of patients with chronic posttraumatic pain on the ulnar side of the wrist. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149010/ doi: 10.1007/s10406-005-0142-5 id: cord-021206-4zyqqgs0 author: nan title: Scientific and Educational Exhibits date: 2007 words: 138669.0 sentences: 8591.0 pages: flesch: 48.0 cache: ./cache/cord-021206-4zyqqgs0.txt txt: ./txt/cord-021206-4zyqqgs0.txt summary: Purpose: To analyze the clinical and imaging fi ndings of BI-RADS category 3 breast lesions by mammographic and ultrasonographic (US) assessment ultimately diagnosed as malignancy in retrospect Methods and Materials: Of 3,207 cases of US-guided core needle biopsy for 4 years, category 3 was given after biopsy, based on mammographic and sonographic evaluation, in 1,099 lesions (41.7%) that were composed of 462 palpable and 637 nonpalpable lesions. Background: Regional kinesis alteration of IVS is associated with different cardiac conditions which may have both pathological and physiological meanings of which the most important are the following: a) left bundle branch block that may determine intra-left ventricular asynchrony and may represent an independent predictor of severe cardiac events in heart failure patients; b) pulmonary embolism that increase right ventricle pressure; c) constrictive pericarditis; d) restrictive cardiomyopathies; e) post-operative cardiac surgery. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149153/ doi: 10.1007/s10406-007-0215-8 id: cord-021713-e0hzcag6 author: nan title: Ribavirin date: 2015-10-21 words: 10899.0 sentences: 501.0 pages: flesch: 37.0 cache: ./cache/cord-021713-e0hzcag6.txt txt: ./txt/cord-021713-e0hzcag6.txt summary: A 38-year-old man developed ischemic optic neuropathy after taking ribavirin 800 mg/day þ peginterferon alfa for 6 months; his visual acuity and field defect failed to improve despite withdrawal of interferon and therapy with high dose systemic steroids [46] . Type 1 diabetes mellitus and thyroid disease reportedly develop in 0.08-2.6% and 10-15% of patients treated with combined interferon-alfa þ ribavirin for chronic hepatitis C, but rarely coexist; however, both conditions have been reported in a 33-year-old woman [65] . A 49-year-old man who took long-term ribavirin þ peginterferon alfa for chronic hepatitis C developed an autoimmune hemolytic anemia after 56 weeks of therapy and required transfusion and withdrawal of both agents [67] . In a randomized controlled trial of high-dose interferon alfa-2b plus oral ribavirin for 6 or 12 months in 50 patients with chronic hepatitis C, the sequential effects of treatment on hemoglobin, leukocytes, and platelets were recorded [78] . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151912/ doi: 10.1016/b978-0-444-53717-1.01403-7 id: cord-022501-9wnmdvg5 author: nan title: P1460 – P1884 date: 2015-12-28 words: 128256.0 sentences: 7808.0 pages: flesch: 51.0 cache: ./cache/cord-022501-9wnmdvg5.txt txt: ./txt/cord-022501-9wnmdvg5.txt summary: Methods: Using published data on (1) the prevalence of MRSA and other bacterial pathogens causing cSSSI in the US, (2) the in-vitro susceptibility rates of commonly used regimens in cSSSI in the US in relation to the most pervasive pathogens identified above, and (3) estimated costs of failure of initial, empiric treatment from a recent study of a large US multi-hospital database, we developed a model to predict the expected clinical and economic impact of increasing prevalence of MRSA. Small outbreaks of VEB-1 ESBL producing Acinetobacter baumannii in Belgian nursing homes and hospitals through cross-border transfer of patients from northern France Methods: From 01/04 to 03/05, all Belgian acute hospitals were invited to report cases of nosocomial infections/colonisations due to MDR Ab isolates presenting a resistance profile similar to the French epidemic strain (resistance to all agents except carbapenems and colistin) and to send such isolates to the reference laboratory for phenotypic confirmation and for genotypic characterization (PCR of VEB-1 and class 1 Integron, PFGE typing). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157935/ doi: 10.1111/j.1470-9465.2006.12_4_1431.x id: cord-022527-a0x6lws3 author: nan title: Eosinophils in Human Disease date: 2012-10-12 words: 56005.0 sentences: 2997.0 pages: flesch: 38.0 cache: ./cache/cord-022527-a0x6lws3.txt txt: ./txt/cord-022527-a0x6lws3.txt summary: The role of the eosinophils as key players in the pathophysiology of asthma has been debated, despite evidence that the cells are present and activated in the airway lumen and tissue 1 of patients with current asthma; are increased in number when asthma is uncontrolled 2 or severe 3 and decreased when asthma is controlled 4 ; and treatment strategies that aim to control airway eosinophilia are significantly more effective and less expensive in improving asthma control 5,6 and decreasing asthma exacerbations compared to guideline-based clinical strategies. 11 Since allergic asthma is primarily a T-helper type 2 (T h 2)-mediated disease, it is not surprising that cytokines driving eosinophilia are T h 2 cell products: specifically, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5), which signal through specific high-affinity cell-surface receptors linked to a common b-chaindall of which can act as eosinophil growth factors that promote formation of eosinophil/basophil (Eo/B) colony-forming units (CFU) in functional assays. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158199/ doi: 10.1016/b978-0-12-394385-9.00013-4 id: cord-022633-fr55uod6 author: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 words: 147405.0 sentences: 8927.0 pages: flesch: 54.0 cache: ./cache/cord-022633-fr55uod6.txt txt: ./txt/cord-022633-fr55uod6.txt summary: Staff satisfaction was evaluated through pre/ post-shift and study surveys; administrative data (physician initial assessment (PIA), length of stay (LOS), patients leaving without being seen (LWBS) and against medical advice [LAMA] ) were collected from an electronic, real-time ED information system. Communication Background: The link between extended shift lengths, sleepiness, and occupational injury or illness has been shown, in other health care populations, to be an important and preventable public health concern but heretofore has not been fully described in emergency medical services (EMS Objectives: To assess the effect of an ED-based computer screening and referral intervention for IPV victims and to determine what characteristics resulted in a positive change in their safety. Objectives: Using data from longitudinal surveys by the American Board of Emergency Medicine, the primary objective of this study was to evaluate if resident self-assessments of performance in required competencies improve over the course of graduate medical training and in the years following. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159364/ doi: 10.1111/j.1553-2712.2012.01332.x id: cord-022650-phsr10jp author: nan title: Abstracts TPS date: 2018-08-14 words: 119675.0 sentences: 7010.0 pages: flesch: 55.0 cache: ./cache/cord-022650-phsr10jp.txt txt: ./txt/cord-022650-phsr10jp.txt summary: 0685 | Skin prick test reactivity to aeroallergens in adult allergy clinic in a tertiary hospital: a 12-year retrospective study Results: Five different human sera were screened for specific IgE level against 29 different allergen sources using test methods of three different suppliers. Conclusion: This multicenter prospective study confirmed that stepwise single-dose OFC to egg will help to clarify the severity of egg allergy, and will contribute to improved food allergy manageMethod: The study design was a retrospective cohort study extracting data from the electronic chart of children older than 4 years who visited our out-patient clinic for egg or milk allergy and who underwent an oral food challenge test (OFC) twice within 24 months between November 2013 and December 2017. Results: In the base case analysis, using Italy clinical practice patients with moderate-to severe allergic rhino-conjunctivitis (SS ranging from 6 to 15 points) and a mean age at entry of 21 years, both SCIT and SLIT were associated with increased cost but superior efficacy compared to pharmacotherapy alone. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159469/ doi: 10.1111/all.13539 id: cord-022653-qa1uph35 author: nan title: Poster Discussion Session PDS date: 2017-08-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159476/ doi: 10.1111/all.13251 id: cord-022658-mq91h15t author: nan title: Executive summary date: 2008-12-30 words: 12004.0 sentences: 656.0 pages: flesch: 37.0 cache: ./cache/cord-022658-mq91h15t.txt txt: ./txt/cord-022658-mq91h15t.txt summary: Patients with rhinitis or asthma caused by allergens for which the clinical efficacy and safety of SIT have been documented by placebo-controlled, doubleblind studies, and those requiring daily pharmacotherapy for longer periods (e.g., preventive treatment during a pollen season or perennially) are candidates for SIT. in most cases when significant airway comorbidity is present (asthma, chronic sinusitis, nasal polyps, or otitis media with effusion) when the diagnosis is in question or special diagnostic testing is required when occupational rhinitis is suspected, to distinguish between clear-cut allergic reactions and toxic or nonallergic reactions when poor symptom control necessitates a consultation for environmental control measures, pharmacotherapy, or specific immunotherapy when medication side-effects are intolerable when rhinitis is only part of a complex series of mucosal allergies. abstract: Allergic rhinitis is now recognized as a major cause of morbidity that significantly impairs function and quality of life. Moreover, it is now widely held that the pathophysiologic mechanisms causing nasal allergy contribute, or predispose many individuals, to the development of other airway diseases, including asthma. Allergic rhinitis may well be a factor in 24% of children with otitis media with effusion (OME), and perhaps 28% of cases of chronic sinusitis. As many as 78% of persons with asthma aged 15 to 30 years have elevated serum IgE antibodies to five common aeroallergens. In many instances, nasal allergy signals the presence of more severe disease. Considerable evidence now suggests that early and appropriate intervention can improve the quality of life and productivity of patients with allergic rhinitis, enhance the academic performance of children, and reduce the prevalence of airway complications. The goal of treatment has shifted from mere symptom alleviation to blocking the pathophysiologic mechanisms that cause chronic allergic inflammation and leave patients vulnerable to airway infections. The earlier in a patient's life that this can be accomplished, the better the anticipated consequences. A panel of experts was convened in Amsterdam, The Netherlands, on 2 September 1996, to explore these issues and their impact on allergy prevention and treatment in primary care. Their undertaking was supported by an unrestricted educational grant from Schering‐Plough Pharmaceuticals. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159496/ doi: 10.1111/j.1398-9995.1998.tb04885.x id: cord-022659-chwk2bs4 author: nan title: Abstracts: Poster session date: 2004-10-08 words: 49153.0 sentences: 2598.0 pages: flesch: 49.0 cache: ./cache/cord-022659-chwk2bs4.txt txt: ./txt/cord-022659-chwk2bs4.txt summary: We investigated the usefulness of informant-based data in Alzheimer''s disease (AD) by comparing caregivers'' subjective evaluations of 83 probable A D patients'' performance on an abbreviated version of the Memory Self-Report Questionnaire to objective evaluations derived from an extensive battery of neuropsychological tests and to clinicians'' evaluations. Compared with 89 subjects (mean age 75.2 yr; 34 men, 55 women) with dementia of the Alzheimer type (DAT), there were no significant group differences for comparable Clinical Dementia Rating stages of dementia for measures of language, Activities of Daily Living, or general cognition. The mean age at onset did not differ significantly between handedness groups (F [ l,lOO] = .82), but the mean duration of symptoms ( Alterations in the optical properties of brain can be used to detect pathological changes in patients with Alzheimer''s disease (AD). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159508/ doi: 10.1002/ana.410320224 id: cord-022888-dnsdg04n author: nan title: Poster Sessions date: 2009-08-19 words: 188640.0 sentences: 9313.0 pages: flesch: 45.0 cache: ./cache/cord-022888-dnsdg04n.txt txt: ./txt/cord-022888-dnsdg04n.txt summary: Methods: Phospho-specific Western blot analyses were performed to verify the functionality of the different IFN-g pathway components, intra-and extracellular flow cytometry experiments were employed to determine the expression of antigen processing components and HLA class I cell surface antigens, quantitative real time-PCR experiments to confirm the absence of JAK2 and presence of pathway relevant molecules as well as, genomic PCR and chromosome typing technique to prove the deletion of JAK2. In order to accomplish these objectives we induced priming or tolerance of ovalbumin (OVA 323-339 peptide)-specific T cells from DO11.10 TCR transgenic mice in vitro or, following adoptive transfer of near physiologically relevant numbers of such cells into recipients, in vivo and correlated functional outcome (via proliferation and cytokine readout assays or antibody production) with E3 ubiquitin-protein ligases expression and the ubiquitination status of the TCR signalling machinery. abstract: No Abtract url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163517/ doi: 10.1002/eji.200990224 id: cord-022940-atbjwpo5 author: nan title: Poster Sessions date: 2016-09-07 words: 241182.0 sentences: 12746.0 pages: flesch: 47.0 cache: ./cache/cord-022940-atbjwpo5.txt txt: ./txt/cord-022940-atbjwpo5.txt summary: We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and controls cell proliferation and tumor growth, on hypoxic regulation of the expression of different proliferation related genes in U87 glioma cells. Transient inhibition of Akt and mTOR protein kinase activation in tumor cells followed by reactivation of signaling pathway did not result in a time-dependent difference on EGFR, HER2 and HER3 expression levels. In our study we aimed to determine cytotoxic effect of RES in K562 human CML cell line and to evaluate the expressions of miRNAs that are associated with genetics of leukemia after treatment with RES; to investigate target genes of miRNAs which show significant expression alterations and molecular mechanisms of RES treatment. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164006/ doi: 10.1111/febs.13808 id: cord-023017-k6edtg58 author: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 words: 65796.0 sentences: 3553.0 pages: flesch: 51.0 cache: ./cache/cord-023017-k6edtg58.txt txt: ./txt/cord-023017-k6edtg58.txt summary: 14/55 (25%) patients in AC who did not discontinue by week 24 received ribavirin dose reduction in comparison to 31/108 ( The clinical outcome in response to combination therapy for treatment of chronic hepatitis C virus (HCV) infection appears to be different for Caucasian versus African American patients. Over the period of combination therapy, most patients in which serum virus titers were reduced to non detectable levels had significant increases in T cell responses to HCV proteins. CHRONIC Background: Recent large prospective trials demonstrated that the combination therapy of interferon (1FN)-alphalribavirin significantly increased the ratio of a sustained virological response in patients with chronic hepatitis C in comparison with IFN monotherapy, especially in patients with high HCV-RNA titer and genotype lb. Results: Patients with chronic HCV infection showed higher MxA gene expression levels than healthy controls, indicating that hepatitis C virus induces IFN production. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165819/ doi: 10.1002/hep.1840380505 id: cord-023033-tgt69ir6 author: nan title: Poster Session (pp. 78A–178A) date: 2006-02-10 words: 16102.0 sentences: 855.0 pages: flesch: 45.0 cache: ./cache/cord-023033-tgt69ir6.txt txt: ./txt/cord-023033-tgt69ir6.txt summary: Methods: We performed a retrospective analysis comparing outcomes, and the incidence, timing, and severity of histologic recurrence of HCV following transplantation in patients who underwent living donor liver transplant compared to recipients of cadaveric organs. Local liver immune responses are thought to play a major role in chronic autoimmune diseases directed at biliary epithelium.Using the apical sodium dependent bile acid transporter (ASBT) promoter to drive biliary epithelial cell -specific expression of a membrane form of ovalbumin (OVA), we have previously developed OVA-BIL transgenic mice. Thus, our AIM was to ascertain whether Kupffer cells express death ligands and contribute to hepatocyte apoptosis and liver fibrosis in the bile duct ligated mouse, an animal model of cholestasis. Control experiments confirmed that Y2 protein inhibited IFNa-induced ISRE-mediated signaling in Huh-T7 cells; relative luciferase activity was reduced from 653 (pH771 IFNP nAb increased HCV core Ag replication by 42% and 23% compared to no treatment (p=O.O1). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165951/ doi: 10.1002/hep.1840380503 id: cord-023049-fio7cjj5 author: nan title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date: 2017-06-22 words: 145485.0 sentences: 7436.0 pages: flesch: 48.0 cache: ./cache/cord-023049-fio7cjj5.txt txt: ./txt/cord-023049-fio7cjj5.txt summary: Clinical efficacy (Medical Research Council sum score, 10-m walk, modified Inflammatory Neuropathy Cause and Treatment score, Overall Neuropathy Limitations Scale, Romberg test) and patient-reported outcomes (36-item Short Form Health Survey , Life Quality Index [LQI] ) were assessed at baseline and at regular intervals until the final visit (10-14 months after switching). To explore the issue of early biomarkers in FAP, we performed skin biopsy and compared IENF density with parameters of nerve conduction studies (NCS) and quantitative sensory testing (QST) on 36 subjects (23 men, aged 55.1 ± 11.1 years) with genetic confirmation of TTR-A97S: 17 patients and 19 carriers. Results: The Gly112Ser mutation causing CMT1C is a mild form of CMT, as patients walked on time, had less weakness than those with Charcot-Marie-Tooth Disease type 1A (CMT1A), had a Charcot Marie Tooth neuropathy score (CMTNS) indicative of mild disease, and had faster ulnar and median motor nerve conduction velocities compared to those with CMT1A. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166380/ doi: 10.1111/jns.12225 id: cord-023157-0lqlx2rv author: nan title: Poster Sessions date: 2013-04-18 words: 128430.0 sentences: 7726.0 pages: flesch: 55.0 cache: ./cache/cord-023157-0lqlx2rv.txt txt: ./txt/cord-023157-0lqlx2rv.txt summary: The patients revealed the increase of free fatty acids level (2.19 AE 0.10) mmol/l/ml, that meaningfully differed from such indexes in the control group (P < 0.001) and low level of adiponektin (3.70 AE 0.70) mg/ml that confirms their role in development of NAFLD even for persons with normal body weight after the presence of abdominal type of adipose tissue distribution. Results: This study has shown effectiveness in reduction in fasting blood glucose (P < 0.01), systolic blood pressure (P = 0.03), diastolic blood pressure (P = 0.01), weight (P = 0.03), added sugar (P = 0.03) and fat consumption (P < 0.01) while improving physical activity (P < 0.01) and insulin sensitivity (P < 0.01) in the intervention group when compared with the control group at follow up assessment. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167176/ doi: 10.1111/1753-0407.12032_1 id: cord-023186-gqltd6u0 author: nan title: Poster Sessions date: 2019-06-27 words: 14365.0 sentences: 814.0 pages: flesch: 55.0 cache: ./cache/cord-023186-gqltd6u0.txt txt: ./txt/cord-023186-gqltd6u0.txt summary: Methods: This is a one-year retrospective study that was conducted in our pediatric intensive care unit (PICU) comparing the intervention failure rate of three different Noninvasive respiratory support modalities (bi-level positive airway pressure (BIPAP), continuous positive airway pressure (CPAP) and HFNC) for infants and young children between the ages of 1 month and 2 years admitted with the diagnosis of bronchiolitis. The aim of the study was to determine the association between Methods: Ninety children aged between > 28 days to < 5 years hospitalized with diagnosis of severe CAP in the Pediatric Department of West Nusa Tenggara Province General Hospital from January to October 2018 were enrolled. Arterial blood gases, respiratory rate, peak inspiratory pressure (PIP) and mean airway pressure (MAP) of rat lung during respiratory support, wetto-dry lung weight ratio, lung homogenate and/or bronchoalveolar lavage fluid tumor necrosis factor-α, macrophage inflammatory protein-2, interleukin-6 and total protein levels were measured and compared among groups after study completion. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167664/ doi: 10.1002/ppul.24373 id: cord-023211-kt5gt26t author: nan title: Poster Session Abstracts date: 2007-08-29 words: 221224.0 sentences: 11772.0 pages: flesch: 52.0 cache: ./cache/cord-023211-kt5gt26t.txt txt: ./txt/cord-023211-kt5gt26t.txt summary: Previous studies performed using fluorescence halide efflux measurements and short-circuit current voltage clamp have shown that treatment with PPARγ (peroxisome proliferator activated receptor gamma) agonists, such as pioglitazone and FLL (FMOC-L-leucine), resulted in an increased biosynthesis and trafficking of ∆F508-CFTR to the cell surface. Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom Recent progress in the development of small molecule correctors and potentiators capable of restoring CFTR function have increased the need for pre-clinical test models including cultured airway epithelial cells from human CF patients as well as CF mouse models. Clinical studies have linked increased sputum and peripheral blood neutrophil MPO activity with increased airflow obstruction in cystic fibrosis (CF) patients of the same age, gender, airway bacterial flora, and CFTR genotype. Because patients expressing low levels of normal CFTR mRNA (5-20%) have mild disease symptoms, these studies demonstrate that the incorporation of the ciliated cell-specific FOXJ1 promoter into gene therapy vectors may be useful for treatment of CF. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167830/ doi: 10.1002/ppul.20700 id: cord-023216-avn8f2w3 author: nan title: Symposium summaries date: 2004-10-18 words: 55670.0 sentences: 2569.0 pages: flesch: 45.0 cache: ./cache/cord-023216-avn8f2w3.txt txt: ./txt/cord-023216-avn8f2w3.txt summary: • relevant past history • recently recommended home physiotherapy program including inhalation therapy (agents, order and timing), airway clearance therapy (ACT) and physical exercise program and adherence • the possibility of gastroesophageal reflux 5 in relation to physiotherapy • clinical status including subjective and objective measures of the following -amount, color, consistency and ease of expectoration of sputum -oximetry/pulmonary function tests/peak expiratory flow rate -breath sounds on auscultation, respiratory rate and pattern of breathing -exercise tolerance (current activity & incidental exercise/ exercise tolerance tests) -musculo-skeletal problems (posture, pain, muscle tightness/weakness, oedema) -urinary incontinence during coughing and forced expirations Assessment of health related quality of life (HRQOL) in children and adolescents with cystic fibrosis (CF) is important to better understand disease and treatment-related factors that impact function and well-being, and to evaluate the effectiveness of therapies and methods of drug delivery. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167881/ doi: 10.1002/ppul.20142 id: cord-023239-06a03o14 author: nan title: II. Topic Sessions date: 2016-06-10 words: 33469.0 sentences: 1470.0 pages: flesch: 39.0 cache: ./cache/cord-023239-06a03o14.txt txt: ./txt/cord-023239-06a03o14.txt summary: The basics of inhaler technique / device / adherence / allergen exposure are all being maintained A retrospective analysis of follow-up of children with difficult asthma for up to six years revealed that those in whom underlying modifiable factors were identified and addressed had an improvement in lung function and reduction in exacerbations over time, while being able to reduce maintenance dose of inhaled steroids such that the majority fell below the threshold for problematic severe asthma 4 . Long-term follow up of children investigated in infancy and reassessed in later childhood have so far showed that reduced baseline lung function in symptomatic infants was significantly associated with subsequent respiratory morbidity as well as with the need of anti-asthma medication at the age of 3 years. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168082/ doi: 10.1002/ppul.23455 id: cord-023288-sqr33y72 author: nan title: Paediatric SIG: Poster Session date: 2008-03-12 words: 30158.0 sentences: 1762.0 pages: flesch: 53.0 cache: ./cache/cord-023288-sqr33y72.txt txt: ./txt/cord-023288-sqr33y72.txt summary: Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169050/ doi: 10.1111/j.1440-1843.2008.01252_11.x id: cord-023298-ysur3sjq author: nan title: Respiratory Nurses SIG: Poster Session date: 2011-03-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169078/ doi: 10.1111/j.1440-1843.2011.01937_16.x id: cord-023302-p9pxz44a author: nan title: Cystic Fibrosis SIG: Poster Session date: 2011-03-21 words: 32008.0 sentences: 1915.0 pages: flesch: 56.0 cache: ./cache/cord-023302-p9pxz44a.txt txt: ./txt/cord-023302-p9pxz44a.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169099/ doi: 10.1111/j.1440-1843.2011.01937_7.x id: cord-023303-fxus38mp author: nan title: Lung Cancer/Bronchology SIGs: Combined Poster Session date: 2008-03-12 words: 30161.0 sentences: 1760.0 pages: flesch: 53.0 cache: ./cache/cord-023303-fxus38mp.txt txt: ./txt/cord-023303-fxus38mp.txt summary: Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169102/ doi: 10.1111/j.1440-1843.2008.01252_8.x id: cord-023305-5lb9kho6 author: nan title: Oliv SIG: Poster Session date: 2011-03-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169107/ doi: 10.1111/j.1440-1843.2011.01937_11.x id: cord-023306-3gdfo6vd author: nan title: TSANZ Oral Abstracts date: 2010-03-01 words: 23387.0 sentences: 1370.0 pages: flesch: 54.0 cache: ./cache/cord-023306-3gdfo6vd.txt txt: ./txt/cord-023306-3gdfo6vd.txt summary: Conflict of Interest No. Purpose We examined age trends in the distribution of stage at diagnosis in patients presenting with non-small cell lung cancer (NSCLC) at tertiary hospitals. Methods Eleven healthy male subjects, aged 28(8) (SD) years completed separate visits with (a) no restriction and (b) chest wall strapping to reduce FVC by 30 (7) Introduction Glossopharyngeal breathing (GPB) is used by competitive breath-hold divers to increase lung gas content above TLC to improve performance. Our DC culture results showed that both MHC-I and MHC-II expression on DCs from COPD were significantly down regulated compare to healthy controls, which could affect MHC restricted Ag presentation, and lead to a failure to activate responder T cells. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169109/ doi: 10.1111/j.1440-1843.2010.01735.x id: cord-023308-af5nihyi author: nan title: COPD SIG: Poster Session 2 date: 2008-03-12 words: 30159.0 sentences: 1761.0 pages: flesch: 53.0 cache: ./cache/cord-023308-af5nihyi.txt txt: ./txt/cord-023308-af5nihyi.txt summary: Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169120/ doi: 10.1111/j.1440-1843.2008.01252_6.x id: cord-023311-7wqdlha4 author: nan title: Oral Session date: 2010-11-24 words: 17248.0 sentences: 956.0 pages: flesch: 51.0 cache: ./cache/cord-023311-7wqdlha4.txt txt: ./txt/cord-023311-7wqdlha4.txt summary: Methods We determined the usefulness of preoperative lung function by spirometry in predicting regression of pulmonary hypertension after surgical correction of mitral stenosis among 20 patients who underwent mitral valve surgery at Philippine Heart Center from July to December 2009. Elderly patients exhibited a signifi cantly higher mortality rate that was independently associated with the following: age; residence status; confusion, urea, respiratory frequency and blood pressure (CURB) score; comorbid conditions; and failure of initial therapy. Methods A total of 40 patients (Male: 50%; Female: 50%) admitted and diagnosed with HAP at our Center were followed up to investigate the rate of adherence of physicians on the diagnosis and treatment of HAP based on Level I and II ATS/IDSA 2008 recommendations and to determine its association with outcome (mortality, mechanical ventilation, ICU stay, hospital stay). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169143/ doi: 10.1111/j.1440-1843.2010.01864.x id: cord-023314-rwjxk8v4 author: nan title: Asthma & Allergy SIG: Poster Session 1 date: 2011-03-21 words: 32009.0 sentences: 1912.0 pages: flesch: 56.0 cache: ./cache/cord-023314-rwjxk8v4.txt txt: ./txt/cord-023314-rwjxk8v4.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169157/ doi: 10.1111/j.1440-1843.2011.01937_1.x id: cord-023331-jrvmgnu3 author: nan title: Asthma & Allergy SIG: Poster Session 3. Physiology, Environment, Investigation and Management date: 2008-03-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169210/ doi: 10.1111/j.1440-1843.2008.01252_3.x id: cord-023333-b7w9zrl6 author: nan title: Oeld/Population Health SIG: Poster Session date: 2011-03-21 words: 32009.0 sentences: 1914.0 pages: flesch: 56.0 cache: ./cache/cord-023333-b7w9zrl6.txt txt: ./txt/cord-023333-b7w9zrl6.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169216/ doi: 10.1111/j.1440-1843.2011.01937_10.x id: cord-023343-y17z9w2x author: nan title: COPD SIG: Poster Session 1 date: 2011-03-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169240/ doi: 10.1111/j.1440-1843.2011.01937_5.x id: cord-023346-8sqbqjm1 author: nan title: MONDAY: POSTERS date: 2005-06-08 words: 130043.0 sentences: 7330.0 pages: flesch: 54.0 cache: ./cache/cord-023346-8sqbqjm1.txt txt: ./txt/cord-023346-8sqbqjm1.txt summary: • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169255/ doi: 10.1111/j.1423-0410.2005.00652.x id: cord-023354-f2ciho6o author: nan title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 words: 130046.0 sentences: 7333.0 pages: flesch: 54.0 cache: ./cache/cord-023354-f2ciho6o.txt txt: ./txt/cord-023354-f2ciho6o.txt summary: • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169300/ doi: 10.1111/j.1423-0410.2005.00654.x id: cord-023364-ut56gczm author: nan title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 words: 130049.0 sentences: 7334.0 pages: flesch: 54.0 cache: ./cache/cord-023364-ut56gczm.txt txt: ./txt/cord-023364-ut56gczm.txt summary: • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169338/ doi: 10.1111/j.1423-0410.2005.00651.x id: cord-023592-w96h4rir author: nan title: Abstracts cont. date: 2015-12-28 words: 67857.0 sentences: 4136.0 pages: flesch: 52.0 cache: ./cache/cord-023592-w96h4rir.txt txt: ./txt/cord-023592-w96h4rir.txt summary: Conclusions: Although the risk of developing more serious gastric lesions increased as the number of virulence factor genes are accumulated in a given Hp strain, we did not find any significant differences or relationship in the cagA, vacA or babA2 status between the Hp isolates from patients with gastritis or peptic ulcer in this study. pneumophila at the serogroup level, it was used in two different outbreaks to demonstrate rapidly the identity of the sequences between strains responsible for severe human infection and those isolated in the hot water reservoir, suggesting a common origin. To determine the antimicrobial resistance in Salmonella and Shigella strains isolated from stool specimens during a 2-year period, from patients admitted to our clinics with a diagnosis of diarrhoea. In our study the susceptibility of 65 bacterial strains isolated in hospital environment (colonising or infecting patients or carried by German cockroaches) to antibiotics and chemical disinfectants was determined. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172567/ doi: 10.1111/j.1469-0691.2004.0902c.x id: cord-023622-tul7bonh author: nan title: Rotaviruses of Man and Animals date: 1975-02-01 words: 1952.0 sentences: 100.0 pages: flesch: 51.0 cache: ./cache/cord-023622-tul7bonh.txt txt: ./txt/cord-023622-tul7bonh.txt summary: Certainly bacterial pathogens may cause both sporadic and epidemic gastroenteritis in children, but they cannot be isolated in up to 75% of cases.2, 3 Whilst it is true that some investigations suggest that enteroviruses or adenoviruses may occasionally cause localised outbreaks of gastroenteritis,4-7 others have shown that these viruses may be detected almost as frequently in controls as among patients. Employing negativestaining techniques on fsecal extracts, FLEWETT and his colleagues found similar particles in children with gastroenteritis in Birmingham 13; indeed, if virologists had only looked at such simply prepared specimens, there is no technical reason why these viruses could not have been detected, say, 15 years ago. Thus, existing evidence suggests that rotaviruses are the most important cause of infantile gastroenteritis throughout the world, but as yet only a limited number of specimens have been examined from those tropical areas where mortality-rates are particularly high. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172916/ doi: 10.1016/s0140-6736(75)91148-4 id: cord-024233-hrzpxdh0 author: nan title: In This Issue/Research Watch/News in Brief date: 2020-04-24 words: 3258.0 sentences: 166.0 pages: flesch: 49.0 cache: ./cache/cord-024233-hrzpxdh0.txt txt: ./txt/cord-024233-hrzpxdh0.txt summary: Circulating tumor DNA analysis to assess risk of progression after long-term response to PD-(L)1 blockade in NSCLC Optimal treatment duration of immune checkpoint inhibitors (ICI) in non-small-cell lung cancer (NSCLC) is not well established. Hellman and colleagues evaluated blood samples using Cancer Personalized Profiling by Deep Sequencing (CAPP-Seq) of 31 advanced NSCLC patients with baseline detectable ctDNA and experiencing long-term benefit to PD-(L)1 blockade (defined as progression-free survival-PFS 12 months) in surveillance. Baseline plasma tumor mutation burden predicts response to pembrolizumab-based therapy in patients with metastatic non-small cell lung cancer The phase III KEYNOTE 010 trial demonstrated survival improvement with pembrolizumab as compared with docetaxel in previously treated PD-L1 positive (cut-off 1%) advanced non-small-cell lung cancer (NSCLC) patients. Following this decision, brigatinib is now indicated as monotherapy for the treatment of adult patients with Anaplastic Lymphoma Kinase (ALK) positive advanced non-small-cell lung cancer previously not treated with ALK inhibitors. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195077/ doi: 10.1016/j.jtho.2020.03.017 id: cord-024651-578c9ut5 author: nan title: 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2020-05-11 words: 84560.0 sentences: 5089.0 pages: flesch: 47.0 cache: ./cache/cord-024651-578c9ut5.txt txt: ./txt/cord-024651-578c9ut5.txt summary: Abstract/Case Report Text Introduction: Mutations in the gene encoding signal transducer and activator of transcription 3 (STAT3) cause autosomal dominant hyperimmunoglobulin E syndrome (AD-HIES) characterized by recurrent skin and sinopulmonary infections, atopic dermatitis, and elevated serum immunoglobulin E (IgE) levels. Objective: The purpose of this study is to increase awareness and improve diagnosis of primary immune deficiency (PID) in the heterogenous group of patients with autoimmune cytopenia (AIC) by identifying clinical characteristics and laboratory biomarkers that distinguish those with underlying PID, disease activity and guide mechanism-based targeted therapy. 7 Chief, Laboratory of Clinical Immunology and Microbiology/National Institute of Allergy and Infectious Diseases, NIAID/National Institutes of Health, NIH Abstract/Case Report Text We have previously used the artificial thymic organoid (ATO) system, based on the 3D aggregation and culture of a delta-like canonical Notch ligand 4-expressing stromal cell line (MS5-Dll4) with CD34+ cells, to study T cell differentiation from CD34+ cells obtained from patients carrying defects that are intrinsic to hematopoietic cells (RAG1-2, AK2, IL2RG) or that affect thymus development (DiGeorge syndrome). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212516/ doi: 10.1007/s10875-020-00764-z id: cord-024833-e6vcf4un author: nan title: Forum date: 2019-12-19 words: 8110.0 sentences: 391.0 pages: flesch: 48.0 cache: ./cache/cord-024833-e6vcf4un.txt txt: ./txt/cord-024833-e6vcf4un.txt summary: Approximately 80% of US hospitals rely on data and recommendations from the ECRI Institute to protect patients from unsafe practices and ineffective products, while the ISMP''s efforts to improve safety in patients have resulted in changes to clinical practice and public policy, including improvements in drug labelling, packaging, preparation and administration. The FDA has now announced the availability of a draft document entitled "Best Practices in Drug and Biological Product Postmarket Safety Surveillance for FDA Staff", which outlines the agency''s approach to timely postmarketing analyses of drugs and biologics, and "includes a high-level overview of tools, methods, and signal detection and evaluation activities, using varied data sources, for drug safety surveillance to provide a broader context and a general overview of our overarching effort and commitment in this area", says Woodcock. Analysis of spontaneous ADR reports to the European Medicine Agency''s EudraVigilance database has identified new safety signals for asthma drugs in paediatric patients, say authors of a study published in Drug Safety. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223806/ doi: 10.1007/s40290-019-00321-z id: cord-026846-3u3x52f8 author: nan title: Inside This Issue date: 2020-06-22 words: 359.0 sentences: 22.0 pages: flesch: 48.0 cache: ./cache/cord-026846-3u3x52f8.txt txt: ./txt/cord-026846-3u3x52f8.txt summary: The authors pooled data on 19,833 patients from 18 randomized trials evaluating outcomes after percutaneous coronary intervention, categorized according to the presence of angiography core laboratory-confirmed moderate or severe coronary artery calcification in any target lesion. This has resulted in an inability to care for patients with valvular and structural heart disease in a timely fashion, potentially placing these patients at increased risk for adverse cardiovascular complications, including CHF and death. In this document, the authors suggest guidelines for how to triage patients in need of structural heart disease interventions and provide a framework for how to decide when it may be appropriate to proceed with intervention despite the ongoing pandemic. In particular, the authors address the triage of patients in need of transcatheter aortic valve replacement and percutaneous mitral valve repair. The authors also address procedural issues and considerations for the function of structural heart disease teams during the COVID-19 pandemic. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295488/ doi: 10.1016/s1936-8798(20)31180-8 id: cord-029211-6o7qn2y2 author: nan title: Press review date: 2020-07-15 words: 6197.0 sentences: 368.0 pages: flesch: 52.0 cache: ./cache/cord-029211-6o7qn2y2.txt txt: ./txt/cord-029211-6o7qn2y2.txt summary: In this study, we aimed to report the 5-year oncological outcomes, including local recurrence, metastatic disease, and survival. Patients age 18 years and older with T2T3 low rectal cancer, of maximum size 4 cm, who were clinically good responders after chemoradiotherapy (residual tumour ≤ 2 cm) were randomly assigned before surgery to either local excision or total mesorectal excision. The primary objective of this study was to assess the 5-year oncological outcomes of local recurrence, metastatic disease, disease-free survival, overall survival, and cancer-specific mortality, which were the secondary endpoints of GRECCAR 2. After 2 years, overall and disease-free survival tended to be improved in simultaneous as compared with delayed-resection groups (P 0.05), a tendency which persisted for OS after a median follow-up of 47 months. This retrospective monocenter study analyzed the shortand long-term outcomes of pancreatectomies associated with arterial resection for patients with either borderline (27%) or locally advanced (73%) pancreatic adenocarcinoma. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361095/ doi: 10.1016/j.jviscsurg.2020.06.014 id: cord-029332-yn603pvb author: nan title: Full Issue PDF date: 2020-07-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363418/ doi: 10.1016/s2666-0849(20)30838-x id: cord-031907-ilhr3iu5 author: nan title: ISEV2020 Abstract Book date: 2020-07-15 words: 200999.0 sentences: 11528.0 pages: flesch: 44.0 cache: ./cache/cord-031907-ilhr3iu5.txt txt: ./txt/cord-031907-ilhr3iu5.txt summary: L.M., and the National Institutes of Health (R35GM119623) to T.R.G. The addition of a size exclusion chromatography step to various urinary extracellular vesicle concentrating methods reveals differences in the small RNA profile Introduction: Urinary extracellular vesicles (EVs) and their RNA cargo are a novel source of biomarkers for various diseases, however non-vesicular RNA (e.g. associated with proteins) is also present within urine. We then evaluated efficiency of heart targeting for eAAV9 or eAAV6 and standard AAV9 or AAV6 encoding for EGFP, mCherry or firefly luciferase in different human cell lines in vitro, in black mouse and in passive immunity nude mouse model in vivo using flow cytometry, confocal microscopy, Langendorff perfusion system and Methods: HLHS patients (n = 3) after Glenn procedure and swine (n = 3) after PAB were given RV injections of allogeneic/xenogeneic MSCs. Donor-specific, HLA-I+, exosomes were isolated from plasma. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480431/ doi: 10.1080/20013078.2020.1784511 id: cord-032588-8bfl2qy1 author: nan title: 51. Jahrestagung der Österreichischen Gesellschaft für Innere Medizin date: 2020-09-18 words: 7862.0 sentences: 837.0 pages: flesch: 54.0 cache: ./cache/cord-032588-8bfl2qy1.txt txt: ./txt/cord-032588-8bfl2qy1.txt summary: Conclusion: In hospitalized patients CoV is associated with a longer LOS, higher number of complications and much higher in-hospital mortality rates compared to influenza virus infections even in a population with less comorbidities. Women with acute heart failure or >75 years have an increased risk of influenza associated in-hospital mortality, while ICU admission and any malignancy are predictors for male patients. Die Eingriffssicherheit wurde anhand der dokumentierten peri-und postinterventionellen Komplikationen bewertet.Ergebnisse: Von April 2019 bis Februar 2020 wurden 14 Patienten mit NYHA II (33 %) oder III (67 %) aufgrund einer TI Grad III-V mittels Implantation eines oder mehrerer MC an der Trikuspidalklappe behandelt. Pro Patient wurden zwischen 1 und 4 Clips an der Trikuspidalklappe implantiert ( Grundlagen: Roxadustat ist ein oraler "Hypoxia-induceable factor"-Prolyhydroxylase-Inhibitor zur Behandlung von Patienten mit Anämie bei chronischer Niereninsuffizienz (CNI). Der vorliegende Abstract zeigt die Resultate einer Interimsanalyse.Methodik: Die Studie schließt Patienten mit NDP-CNI im Stadium 3 bis 5 mit begleitender Anämie ein und hat sie zu Roxadustat-oder DA-Therapie randomisiert. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511243/ doi: 10.1007/s00508-020-01724-8 id: cord-033327-yi1tvsh4 author: nan title: AANP Forum date: 2020-10-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542130/ doi: 10.1016/j.nurpra.2020.08.025 id: cord-034340-3ksfpaf7 author: nan title: Proceedings of the 26th European Paediatric Rheumatology Congress: part 2: Virtual. 23 - 26 September 2020 date: 2020-10-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592179/ doi: 10.1186/s12969-020-00470-5 id: cord-035030-ig4nwtmi author: nan title: 10th European Conference on Rare Diseases & Orphan Products (ECRD 2020) date: 2020-11-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649705/ doi: 10.1186/s13023-020-01550-1 id: cord-255256-8uckmya4 author: nan title: Akzeptierte Abstracts für die COVID-19-bedingt abgesagte DGIIN/ÖGIAIN-Jahrestagung 2020 date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s00063-020-00711-1 doi: 10.1007/s00063-020-00711-1 id: cord-265848-afkeuwup author: nan title: Chapter 2 Emergency Management of Poisoning date: 2007-12-31 words: 27412.0 sentences: 1589.0 pages: flesch: 39.0 cache: ./cache/cord-265848-afkeuwup.txt txt: ./txt/cord-265848-afkeuwup.txt summary: With the use of drugs having a short duration of action, RSI also is advantageous because it is a measure that permits temporary airway control for the patient with mildly compromised airway reflexes who requires gastrointestinal decontamination (lavage followed by activated charcoal administration) but who does not require prolonged intubation. The management of gastrointestinal disturbance in the toxic patient includes following the general principles of blood, fluid, and electrolyte resuscitation, when indicated; judicious use of parenteral antiemetics to control persistent vomiting; specific measures such as antidotal therapy (e.g., in iron or organophosphate poisoning); or interventional therapy, such as charcoal hemoperfusion (in theophylline overdose) or hemodialysis (in lithium overdose), when indicated. abstract: nan url: https://api.elsevier.com/content/article/pii/B9780721606934500074 doi: 10.1016/b978-0-7216-0693-4.50007-4 id: cord-266255-898h9rl1 author: nan title: Full Issue PDF date: 2020-08-31 words: 17676.0 sentences: 980.0 pages: flesch: 45.0 cache: ./cache/cord-266255-898h9rl1.txt txt: ./txt/cord-266255-898h9rl1.txt summary: Thus, in addition to a more severe LHD at baseline, patients whose TR progress represents a subset characterized by an accelerated course of LHD, including a more rapid increase in LA size, pulmonary pressures, and higher rates of new atrial fibrillation, reduction in LVEF, worsening valvular disease, and need for pacemaker or device therapy. Increased LA LGE has been found to be associated with future diagnosis of atrial arrhythmias in patients with preexisting cardiac disease (9) but no study has investigated the prognostic value of LA LGE in a population-based cohort or by use of continuous monitoring. Positron Emission Tomography) study revealed that total sympathetic denervation size independently predicts appropriate ICD therapy for fast VA (7 ACE ¼ angiotensin converting enzyme; ARB ¼ angiotensin-II-receptor blocker; CFR ¼ coronary flow reserve; CI ¼ confidence interval; HED ¼ hydroxyephedrine; HR ¼ hazard ratio; LVEDVi ¼ leftventricular end-diastolic volume index; LVEF ¼ left-ventricular ejection fraction; MBF ¼ myocardial blood flow; NT-proBNP ¼ N-terminal prohormone of brain natriuretic peptide; NYHA ¼ New York Heart Association; RI ¼ retention index. abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1936878X20305817 doi: 10.1016/s1936-878x(20)30581-7 id: cord-269591-lu415jcp author: nan title: Recommendations Regarding COVID19 Infection in Rheumatic Patients in Greece date: 2020-03-31 words: 835.0 sentences: 55.0 pages: flesch: 41.0 cache: ./cache/cord-269591-lu415jcp.txt txt: ./txt/cord-269591-lu415jcp.txt summary: authors: nan Based on the above limited data, our National Society, taking into account the critical situation with the COVID19 infection worldwide and the potential risk for severe disease in our patients: Although the World Health Organisation (WHO), 6 the National Organisation of Public Health in Greece (https:// eody.gov.gr/covid-19-odigies-therapeias/) and experts in the field 7 do not recommend glucocorticoids (GCs) in patients with severe COVID19 infection, in a recent retrospective study from China, administration of methylprednisolone in patients with acute respiratory distress syndrome (ARDS) resulted in a significant reduction in mortality (from 62% to 46%, Hazard Ratio = 0.38). WHO: Clinical Management Of Severe Acute Respiratory Infection (SARI) When COVID-19 Disease Is Suspected. Risk Factors Associated With Acute Respiratory Distress Syndrome And Death In Patients With Coronavirus Disease 2019 Pneumonia In Wuhan, China abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32411928/ doi: 10.31138/mjr.31.1.6 id: cord-282783-ps5jyjkl author: nan title: Full Issue PDF date: 2020-09-30 words: 15926.0 sentences: 843.0 pages: flesch: 41.0 cache: ./cache/cord-282783-ps5jyjkl.txt txt: ./txt/cord-282783-ps5jyjkl.txt summary: The Childhood Cancer Survivor Study showed a 10-fold higher risk of pericardial disease in all CCS versus siblings (30year cumulative incidence, 3 .0%) and a dose-response relation with chest RT (11) . The literature on ECG abnormalities in large cohorts of long-term CCS is sparse (46, 47) , Data on the use of ambulatory ECG monitoring to define the prevalence of brady-and tachyarrhythmias induced by cardiotoxic cancer treatments are needed, but must be carefully weighed against the potential patient burden and clinical significance. Interestingly, a prior study in testicular cancer survivors showed that those patients who were exposed to cisplatin-based chemotherapy nearly 3 to more than 20 years ago had a more severe reduction in FMD and higher levels of circulating endothelial cells than those not exposed (13) . abstract: nan url: https://doi.org/10.1016/s2666-0873(20)30180-0 doi: 10.1016/s2666-0873(20)30180-0 id: cord-286574-t9z2ynt5 author: nan title: Speaker presentations date: 2017-09-30 words: 14833.0 sentences: 690.0 pages: flesch: 40.0 cache: ./cache/cord-286574-t9z2ynt5.txt txt: ./txt/cord-286574-t9z2ynt5.txt summary: Data on the economic impact of AMR in major pathogens showed that healthcare costs significantly increase in the treatment of infections caused by antibiotic-resistant strains (Maragakis et al. In principle, the major high-level goals consist of optimizing the use of such drugs in health and agriculture and minimizing environmental contamination; sustaining the development of new classes of antimicrobials drugs and other medicines and making them affordable and accessible to all who need them; and much more effective application of infection control and prevention principles. These new agents are bound to change the paradigm for the treatment of infections caused by colistin-resistant Gram-negatives, but uncertainties are still likely to remain, including which agent to use, how to optimize dosing in to maximize efficacy and minimize toxicity as well as potential for development of resistance, and whether use of more than one agent would still be needed. abstract: nan url: https://api.elsevier.com/content/article/pii/S0924857917303400 doi: 10.1016/s0924-8579(17)30340-0 id: cord-289581-aozg3o9o author: nan title: Abstracts der 54. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date: 2016-08-25 words: 16405.0 sentences: 1905.0 pages: flesch: 54.0 cache: ./cache/cord-289581-aozg3o9o.txt txt: ./txt/cord-289581-aozg3o9o.txt summary: Daher geht eine erhöhte Neutrophile/Lymphozyten Ratio (NLR) mit einem ungünstigen kardiometabolischen Profil einher und konnte bereits als Marker für kardiovaskuläre Erkrankungen im Erwachsenenalter bei Pa-tientInnen ohne Diabetes mellitus herangezogen werden. Ziel: Wir bestimmten den zeitlichen Verlauf der Symptome während und bis zu 9 Stunden nach dem Fruktosetest bei Kindern die sensitiv auf Fruktose reagierten. 60 konsekutive Patienten (Alter: 10-15 Jahre; 28 männlich, 33 weiblich) mit chronisch abdominellen Beschwerden erhielten einen Fruktose H2-Atemtest zur Abklärung des Verdachts auf Kohlenhydratmalabsorption; eine 20 % Fruktoselösung wurde dafür verabreicht, 1 g/kg Körpergewicht bis zu maximal 25 g.Die Diagnose einer Fruktosemalabsorption wurde gestellt, wenn der Anstieg der H2-Atemluftkonzentration über 20 ppm betrug. Nach HDMTX-Gabe zeigten sich in der untersuchten Kohorte breit gestreute und großteils signifikante Blutbildveränderungen, welche jedoch zusätzlich durch die protokollgemäße, gleichzeitige Gabe von Purinethol (6-Mercaptopurin) (mit-)verursacht sein können. Wir berichten von einem 5-jährigen Mädchen bei dem aufgrund erheblicher therapieassoziierter Toxizität im Rahmen der Therapie eines Medulloblastoms die Erstdiagnose einer Ataxia teleangiectasia vor Auftreten charakteristischer Stigmata gestellt wurde. abstract: nan url: https://doi.org/10.1007/s00112-016-0156-1 doi: 10.1007/s00112-016-0156-1 id: cord-313474-1gux1gsi author: nan title: Physicians Abstracts date: 2015-03-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/25794251/ doi: 10.1038/bmt.2015.27 id: cord-326785-le2t1l8g author: nan title: Pathological Society of Great Britain and Ireland. 163rd meeting, 3–5 July 1991 date: 2005-06-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/1681042/ doi: 10.1002/path.1711640412 id: cord-335597-anrzcsrt author: nan title: 44. Jahrestagung der Österreichischen Gesellschaft für Pneumologie date: 2020-10-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s00508-020-01745-3 doi: 10.1007/s00508-020-01745-3 id: cord-335918-uc225mhn author: nan title: COVID-19 Guidance for Triage of Operations for Thoracic Malignancies: A Consensus Statement from Thoracic Surgery Outcomes Research Network date: 2020-04-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The extraordinary demands of managing the COVID-19 pandemic has disrupted the world’s ability to care for patients with thoracic malignancies. As a hospital’s COVID-19 population increases and hospital resources are depleted, the ability to provide surgical care is progressively restricted - forcing surgeons to prioritize among their cancer populations. Representatives from multiple cancer, surgical and research organizations have come together to provide a guide for triaging patients with thoracic malignancies, as the impact of COVID-19 evolves as each hospital. url: https://www.ncbi.nlm.nih.gov/pubmed/32689703/ doi: 10.1016/j.jtcvs.2020.03.061 id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1186/s13613-017-0345-7 doi: 10.1186/s13613-017-0345-7 id: cord-341063-3rqnu5bu author: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1186/s13054-018-1973-5 doi: 10.1186/s13054-018-1973-5 id: cord-350571-6tapkjb6 author: nan title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/28074393/ doi: 10.1007/s11096-016-0404-4 id: cord-351195-2fdqu2l1 author: nan title: How to manage, after containment, patients with chronic conditions at risk? date: 2020-07-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0001407920303952 doi: 10.1016/j.banm.2020.07.014 id: cord-353293-vjdwh19x author: nan title: Post-COVID-19 global health strategies: the need for an interdisciplinary approach date: 2020-06-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: For survivors of severe COVID-19 disease, having defeated the virus is just the beginning of an uncharted recovery path. What follows after the acute phase of SARS-CoV-2 infection depends on the extension and severity of viral attacks in different cell types and organs. Despite the ridiculously large number of papers that have flooded scientific journals and preprint-hosting websites, a clear clinical picture of COVID-19 aftermath is vague at best. Without larger prospective observational studies that are only now being started, clinicians can retrieve information just from case reports and or small studies. This is the time to understand how COVID-19 goes forward and what consequences survivors may expect to experience. To this aim, a multidisciplinary post-acute care service involving several specialists has been established at the Fondazione Policlinico Universitario A. Gemelli IRCSS (Rome, Italy). Although COVID-19 is an infectious disease primarily affecting the lung, its multi-organ involvement requires an interdisciplinary approach encompassing virtually all branches of internal medicine and geriatrics. In particular, during the post-acute phase, the geriatrician may serve as the case manager of a multidisciplinary team. The aim of this article is to describe the importance of the interdisciplinary approach––coordinated by geriatrician––to cope the potential post-acute care needs of recovered COVID-19 patients. url: https://doi.org/10.1007/s40520-020-01616-x doi: 10.1007/s40520-020-01616-x id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32048060/ doi: 10.1186/s13613-020-0623-7 id: cord-307862-a082sghm author: ten Cate, Hugo title: Thrombosis management in times of COVID-19 epidemy; a Dutch perspective date: 2020-04-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32336956/ doi: 10.1186/s12959-020-00220-3 id: cord-003376-2qi4aibx author: van de Groep, Kirsten title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study date: 2018-12-18 words: 3889.0 sentences: 191.0 pages: flesch: 42.0 cache: ./cache/cord-003376-2qi4aibx.txt txt: ./txt/cord-003376-2qi4aibx.txt summary: title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study Cytomegalovirus (CMV) reactivation is observed in 14-41% of intensive care unit (ICU) patients without known prior immune deficiency [1] [2] [3] and is associated with increased morbidity and mortality [4] [5] [6] . Therefore, this longitudinal study aimed to investigate whether the temporal course of seven host response biomarkers, including both pro-and anti-inflammatory cytokines, in previously immunocompetent ICU patients with sepsis differs between patients with and without CMV reactivation. Time trends of various markers within patients were described by symmetric percentage differences relative to their levels 2 days prior to CMV viremia onset (Fig. 2 for primary comparison, Additional file 1: Figure S1 for secondary comparison). We performed an explorative study to compare time trends of host response biomarkers in patients with reactivation that were matched to non-reactivating control patients who were either seropositive or seronegative for CMV. abstract: BACKGROUND: Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. Therefore, we studied the effects of CMV reactivation on the temporal course of host response biomarkers in patients with sepsis. METHODS: In this matched cohort study, each sepsis patient developing CMV reactivation between day 3 and 17 (CMV+) was compared with one CMV seropositive patient without reactivation (CMVs+) and one CMV seronegative patient (CMVs−). CMV serostatus and plasma loads were determined by enzyme-linked immunoassays and real-time polymerase chain reaction, respectively. Systemic interleukin-6 (IL-6), IL-8, IL-18, interferon-gamma–induced protein-10 (IP-10), neutrophilic elastase, IL-1 receptor antagonist (RA), and IL-10 were measured at five time points by multiplex immunoassay. The effects of CMV reactivation on sequential concentrations of these biomarkers were assessed in multivariable mixed models. RESULTS: Among 64 CMV+ patients, 45 could be matched to CMVs+ or CMVs− controls or both. The two baseline characteristics and host response biomarker levels at viremia onset were similar between groups. CMV+ patients had increased IP-10 on day 7 after viremia onset (symmetric percentage difference +44% versus −15% when compared with CMVs+ and +37% versus +4% when compared with CMVs−) and decreased IL-1RA (−41% versus 0% and −49% versus +10%, respectively). However, multivariable analyses did not show an independent association between CMV reactivation and time trends of IL-6, IP-10, IL-10, or IL-1RA. CONCLUSION: CMV reactivation was not independently associated with changes in the temporal trends of host response biomarkers in comparison with non-reactivating patients. Therefore, these markers should not be used as surrogate clinical endpoints for interventional studies evaluating anti-CMV therapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13054-018-2261-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299562/ doi: 10.1186/s13054-018-2261-0 id: cord-262551-hxhlhb5m author: van der Gronde, Toon title: Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress date: 2020-05-06 words: 5752.0 sentences: 319.0 pages: flesch: 42.0 cache: ./cache/cord-262551-hxhlhb5m.txt txt: ./txt/cord-262551-hxhlhb5m.txt summary: CONCLUSIONS: We propose to open up a symptom-based, mood-centered view to a model in which adolescent depression is framed as a consecutive failure of stress coping mechanisms and chronic exhaustion. We offer an alternative integrated approach for the treatment of adolescent and young adult depression by focusing on stress factors and exhaustion reduction, seeing anhedonia and withdrawal as an evolutionary coping mechanism. Reframing depression and shifting clinical practice to a more comprehensive and integrated look at the individual experience of a patient, including all causes for stress, pressure, and exhaustion, might be more helpful in developing promising treatment strategies. Using a combination of treatment modalities could increase therapeutic effectiveness by improving the pace of learning new coping behaviors, exerting a synergistic impact on the developmental perspective, and breaking the downward spiral of stress and exhaustion, which eventually leads to a reduction of the depression symptoms. abstract: OBJECTIVE: Adolescent depression is a heterogeneous disorder, with a wide variety of symptoms and inconsistent treatment response, and is not completely understood. A dysregulated stress system is a consistent finding, however, and exhaustion is a consistent trait in adolescent patients. The aim of this paper is to critically assess current hypotheses in adolescent depression research and reframe causes and treatment approaches. METHODS: A mixed-method approach involved a review based on publications from PubMed, Embase and PsycInfo, and two exemplary adolescent cases. RESULTS: Both cases show a spiral of stress and exhaustion, but with a different profile of symptoms and coping mechanisms. Reframing both cases from the perspective of coping behavior, searching for the sources of experienced stress and exhaustion, showed coping similarities. This proved essential in the successful personalized treatment and recovery process. In combination with recent evidence, both cases support the functional reframing of depression as the outcome of a stress- and exhaustion-related spiralling mechanism. CONCLUSIONS: We propose to open up a symptom-based, mood-centered view to a model in which adolescent depression is framed as a consecutive failure of stress coping mechanisms and chronic exhaustion. Addressing exhaustion and coping primarily as a treatment strategy in adolescents and young adults might work in synergy with existing treatments and improve overall outcomes. This perspective warrants further investigation. url: https://doi.org/10.3389/fpsyt.2020.00412 doi: 10.3389/fpsyt.2020.00412 id: cord-333024-1yrmun3z author: von Lilienfeld-Toal, Marie title: Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology date: 2016-09-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly. METHODS: A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus. RESULTS: CRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis. CONCLUSIONS: CRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome. url: https://api.elsevier.com/content/article/pii/S0959804916323887 doi: 10.1016/j.ejca.2016.08.015 id: cord-280507-1nf2ycp3 author: Álvarez‐Román, MT title: Clinical trials and Haemophilia during the COVID‐19’ pandemic: Madrid’s Experience date: 2020-05-16 words: 1090.0 sentences: 61.0 pages: flesch: 49.0 cache: ./cache/cord-280507-1nf2ycp3.txt txt: ./txt/cord-280507-1nf2ycp3.txt summary: Communication between all members of a research team is key to adapting the development of clinical trials to the context of the epidemiological crisis of coronavirus. Communication between all members of a research team is key to adapting the development of clinical trials to the context of the epidemiological crisis of coronavirus. These shipments of medication coincided with visits made by telephone by the investigator delegated as responsible for the research team, and by the study coordinator and/or the trial nurse. Regarding in-person visits with patients, there were two occasions where patients picked up the medication at the beginning of March at Hospital La Paz. One paediatric patient received prophylaxis by nurses because the training for the administration of the treatment had not yet taken place. All rights reserved There was another in-person visit by an adult patient for the administration of subcutaneous medication by the nurses of the centre, because he was not trained to administer it himself. abstract: In times of crisis, continuous adaptation is necessary. Communication between all members of a research team is key to adapting the development of clinical trials to the context of the epidemiological crisis of coronavirus. We are accustomed to performing day‐to‐day tasks to fulfil protocol requirements with precision. To this end, we typically have had protocol‐guided face‐to‐face visits and we have followed a detailed sequenced procedure during each visit. url: https://doi.org/10.1111/hae.14055 doi: 10.1111/hae.14055 id: cord-260105-ckh8jp9e author: Ñamendys-Silva, Silvio A title: Respiratory support for patients with COVID-19 infection date: 2020-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2213260020301107 doi: 10.1016/s2213-2600(20)30110-7 id: cord-014933-3jezc081 author: Özdemir, Seray Karagöz title: Investigation of seasonal frequency and pathogens in febrile neutropenia date: 2019-01-15 words: 1807.0 sentences: 110.0 pages: flesch: 51.0 cache: ./cache/cord-014933-3jezc081.txt txt: ./txt/cord-014933-3jezc081.txt summary: authors: Özdemir, Seray Karagöz; Iltar, Utku; Salim, Ozan; Yücel, Orhan Kemal; Erdem, Ramazan; Turhan, Özge; Undar, Levent The first aim of study was to determine the difference in frequency of febrile neutropenic episodes (FNEs) according to months and seasons. Febrile neutropenia (FEN) is the most common complication requiring hospitalization and causing mortality in patients with hematological cancer. The primary aim of the study was to investigate whether there is a relationship between the frequency of febrile neutropenic episodes (FNEs) and seasons in hematological cancer patients. In addition, neutrophil count, C-reactive protein (CRP) level, length of hospitalization, culture results of blood and other body specimens, isolated pathogens, detected foci of infection, and antibacterial, antiviral, or antifungal treatments were reviewed. The second aim of the study was to determine the type and frequency of pathogens detected in FNEs in patients with hematologic cancer. abstract: BACKGROUND: In patients with hematological malignancies, febrile neutropenia (FEN) is the most frequent complication and the most important cause of mortality. Various risk factors have been identified for severe infection in neutropenic patients. However, to the best of our knowledge, it is not defined whether there is a change in the risk of febrile neutropenia according to seasons. The first aim of study was to determine the difference in frequency of febrile neutropenic episodes (FNEs) according to months and seasons. The second aim was to document isolated pathogens, as well as demographical and clinical characteristics of patients. METHODS: In the study, 194 FNEs of 105 patients who have been followed with hematological malignancies between June 2013 and May 2014 were evaluated retrospectively. RESULTS: Although the number of FNEs increased in autumn, there was no significant difference in frequency of FNEs between months (p = 0.564) and seasons (p = 0.345). There was no isolated pathogen in 54.6% of FNEs. In 45.4% of 194 FNEs, pathogens were isolated. Of all pathogens, 50.4% were gram negative bacteria, 29.2% were gram positive bacteria, 13.3% were viruses, 5.3% were fungi, and 1.8% were parasites. CONCLUSİONS: The frequency of FEN does not change according to months or seasons. Also, the relative proportions of different pathogens in the cause of FEN do not vary according to seasons. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091104/ doi: 10.1007/s12254-018-0468-z id: cord-342246-tnjtd9n3 author: Özçelik Korkmaz, Müge title: Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection date: 2020-10-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: The aim of our study is to evaluate the incidence and characteristics of otolaryngology symptoms in COVID 19 patients. METHODS: 116 patients with positive PCR test results for COVID-19 and followed up by otolaryngologists at a tertiary referral center/COVID-19 pandemic hospital were questioned in terms of otolaryngology symptoms associated with COVID-19 infection. Data including demographics, disease severity, concomitant diseases, previous otolaryngologic diseases,incidence and duration of new onset symptoms were collected and categorically analyzed. In addition, the severity of loss of smell and taste was evaluated by visual analogue score (VAS). RESULTS: A total of 58 men and 58 women participated. The mean age of the patients was 57.24 ± 14.32 (19–83). The most common otolaryngological findings were hyposmia/anosmia (37.9%) and hypogeusia/ageusia (41.37%), respectively. These complaints were followed by headache (37.1%), and nausea/vomiting (31%). The most common oropharyngeal symptoms were sore throat (32.7%) and dysphagia (20.6%). The rate of otological/vestibular symptoms was dizziness (31.8%), tinnitus (11%), true vertigo (6%), and hearing impairment (5.1%), respectively. The most of symptoms were more frequent in > 60 years and women. There was a significant correlation between nasal itching and smell disturbance in patients with allergic rhinitis. Considering the duration of symptoms, the longest were hyposmia/anosmia and hypogeusia/ageusia. The mean VAS’s in patients with hyposmia/anosmia and hypogeusia/ageusia were 5.52 ± 2.08 and 5.79 ± 2.21, respectively. CONCLUSION: The most common otolaryngologic symptoms of COVID-19 infection are known as sore throat, smell and/or taste disturbances. However, our study showed that these patients can be seen with different symptoms in otological or laryngeal areas. Therefore, a more careful evaluation should be made in terms of otolaryngologic symptoms when COVID 19 infection is suspected. url: https://doi.org/10.1007/s00405-020-06396-8 doi: 10.1007/s00405-020-06396-8 id: cord-258027-f3rr5el1 author: Østby, Anne‐Cathrine title: Respiratory virology and microbiology in intensive care units: a prospective cohort study date: 2013-05-18 words: 5259.0 sentences: 268.0 pages: flesch: 38.0 cache: ./cache/cord-258027-f3rr5el1.txt txt: ./txt/cord-258027-f3rr5el1.txt summary: Our aim was to determine the frequency of 12 common respiratory viruses in patients admitted to intensive care units with respiratory symptoms, evaluate the clinical characteristics and to compare the results to routine microbiological diagnostics. The information included the following: age, gender, underlying comorbidity, use of immunosuppressant drugs, respiratory symptoms, diagnoses on admission, diagnoses on discharge, length of hospital stay, ICU stay and intubation, Simplified Acute Physiology Score II (SAPS II)scores, administration of antibiotics, non-invasive ventilation, chest x-ray, laboratory analyses and results of the physical examination, which included temperature, saturation, stethoscopic findings and clinical signs of respiratory infection or distress. Viruses -Of the 122 patients included in the study group, 19 (16%) were positive for a virus, of which the most frequently detected were influenza A (n = 9) and RSV (n = 3, Fig. 2 ). abstract: Our aim was to determine the frequency of 12 common respiratory viruses in patients admitted to intensive care units with respiratory symptoms, evaluate the clinical characteristics and to compare the results to routine microbiological diagnostics. Throat swabs from 122 intensive care‐patients >18 years with acute respiratory symptoms were collected upon admission and analysed with multiplex real‐time polymerase chain reaction, for 12 community respiratory viruses. Blood and respiratory tract specimens were analysed for bacteria and fungi upon clinicians' request. Clinical and paraclinical data were collected. Viruses were detected in 19 (16%) of the 122 study patients. Five virus‐positive patients (26%) had possible clinically relevant bacteria or fungi co‐detected. Patients with exacerbation in COPD were associated with a viral infection (p = 0.02). Other comorbidities, clinical and paraclinical parameters, and death were independent of a viral infection or co‐detection of bacteria/fungi. In conclusion, respiratory viruses were frequently detected in the patients. The investigated clinical and paraclinical parameters were not different in viral infections compared to other agents, thus respiratory viruses likely have similar impact on the clinical course as other agents. In 25% of the virus‐positive patients, polymicrobial aetiology was identified. Comprehensive and sensitive diagnostic methods should be emphasized to enhance respiratory diagnostics. url: https://doi.org/10.1111/apm.12089 doi: 10.1111/apm.12089 id: cord-313894-stgx36h5 author: Ürün, Yüksel title: Survey of the Impact of COVID-19 on Oncologists’ Decision Making in Cancer date: 2020-08-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To understand readiness measures taken by oncologists to protect patients and health care workers from the novel coronavirus (COVID-19) and how their clinical decision making was influenced by the pandemic. METHODS: An online survey was conducted between March 24 and April 29, 2020. RESULTS: A total of 343 oncologists from 28 countries participated. The median age was 43 years (range, 29-68 years), and the majority were male (62%). At the time of the survey, nearly all participants self-reported an outbreak in their country (99.7%). Personal protective equipment was available to all participants, of which surgical mask was the most common (n = 308; 90%). Telemedicine, in the form of phone or video encounters, was common and implemented by 80% (n = 273). Testing patients with cancer for COVID-19 via reverse transcriptase polymerase chain reaction before systemic treatment was not routinely implemented: 58% reported no routine testing, 39% performed testing in selected patients, and 3% performed systematic testing in all patients. The most significant factors influencing an oncologist’s decision making regarding choice of systemic therapy included patient age and comorbidities (81% and 92%, respectively). Although hormonal treatments and tyrosine kinase inhibitors were considered to be relatively safe, cytotoxic chemotherapy and immune therapies were perceived as being less safe or unsafe by participants. The vast majority of participants stated that during the pandemic they would use less chemotherapy, immune checkpoint inhibitors, and steroids. Although treatment in neoadjuvant, adjuvant, and first-line metastatic disease was less affected, most of the participants stated that they would be more hesitant to recommend second- or third-line therapies in metastatic disease. CONCLUSION: Decision making by oncologists has been significantly influenced by the ongoing COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32755479/ doi: 10.1200/go.20.00300 id: cord-274782-yymo9i6r author: Şahbat, Yavuz title: Management of orthopedic oncology patients during coronavirus pandemic date: 2020-07-02 words: 1930.0 sentences: 116.0 pages: flesch: 49.0 cache: ./cache/cord-274782-yymo9i6r.txt txt: ./txt/cord-274782-yymo9i6r.txt summary: At first glance, the coronavirus disease 2019 (COVID‐19) pandemic and orthopedics may seem to be unrelated disciplines, but the provision of healthcare services to patients who require them proves that these two fields are parts of the same whole. The main purpose of this article is to discuss how orthopedic oncology clinics should be organized during the pandemic and to present the process management scheme for patients requiring orthopedic surgery, including trauma surgery, from diagnosis to treatment, together with our experiences. The main purpose of this article is to discuss how orthopedic oncology clinics should be organized during the pandemic and to present the process management scheme for patients requiring orthopedic surgery, including trauma surgery, from diagnosis to treatment, together with our experiences. We obtained data from the hospital information system regarding all oncologic orthopedics and trauma surgery patients operated on and followed between 11 March 2020, the date of the first confirmed case of coronavirus in Turkey, and 11 May 2020. abstract: The new measures implemented in hospitals also altered the operation of orthopedics and traumatology departments. The main purpose of this article is to discuss how orthopedic oncology clinics should be organized during the pandemic and to present the process management scheme for patients requiring orthopedic surgery, including trauma surgery, from diagnosis to treatment, together with our experiences. Instead of thinking about the global emergence of the epidemic, it is time to act decisively. At first glance, the coronavirus disease 2019 (COVID‐19) pandemic and orthopedics may seem to be unrelated disciplines, but the provision of healthcare services to patients who require them proves that these two fields are parts of the same whole. Our experiences in treating neutropenic, lymphocytopenic, and chemotherapy patients seem to have proven beneficial during this process. We operated on 10 biopsy patients, 15 primary bone sarcomas, 9 soft tissue sarcomas, and 82 trauma patients within this time frame. Only three patients were suspected to have COVID‐19 before admission. The early identification, strict isolation, and effective treatment of these patients prevented any nosocomial infections and disease‐related comorbidities. This success is the result of the multidisciplinary cooperation of the Ministry of Health, our hospital, and our clinic. url: https://www.ncbi.nlm.nih.gov/pubmed/32617984/ doi: 10.1002/jso.26092 id: cord-319567-4t5t8bcx author: Şentürk, Mert title: Thoracic Anesthesia of Patients with Suspected or Confirmed 2019 Novel Coronavirus Infection: Preliminary Recommendations for Airway Management by the EACTA Thoracic Subspecialty Committee date: 2020-04-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The novel coronavirus has caused a pandemic around the world. Management of patients with suspected or confirmed coronavirus infection who have to undergo thoracic surgery will be a challenge for the anesthesiologists. infection who have to undergo thoracic surgery will be a challenge for the anesthesiologists. The thoracic subspecialty committee of European Association of Cardiothoracic Anaesthesiology (EACTA) has conducted a survey of opinion in order to create recommendations for the anesthetic approach to these challenging patients. It should be emphasized that both the management of the infected patient with COVID-19 and the self-protection of the anesthesia team constitute a complicated challenge. The text focuses therefore on both important topics. url: https://www.ncbi.nlm.nih.gov/pubmed/32414544/ doi: 10.1053/j.jvca.2020.03.059 ==== make-pages.sh questions [ERIC WAS HERE] parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/list-questions.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 93. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/list-questions.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 92. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. ==== make-pages.sh search /data-disk/reader-compute/reader-cord/bin/make-pages.sh: line 77: /data-disk/reader-compute/reader-cord/tmp/search.htm: No such file or directory Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/tsv2htm-search.py", line 51, in with open( TEMPLATE, 'r' ) as handle : htm = handle.read() FileNotFoundError: [Errno 2] No such file or directory: '/data-disk/reader-compute/reader-cord/tmp/search.htm' ==== make-pages.sh topic modeling corpus Zipping study carrel